# Path Configuration
from tools.preprocess import *

# Processing context
trait = "Bladder_Cancer"
cohort = "GSE253531"

# Input paths
in_trait_dir = "../DATA/GEO/Bladder_Cancer"
in_cohort_dir = "../DATA/GEO/Bladder_Cancer/GSE253531"

# Output paths
out_data_file = "./output/preprocess/1/Bladder_Cancer/GSE253531.csv"
out_gene_data_file = "./output/preprocess/1/Bladder_Cancer/gene_data/GSE253531.csv"
out_clinical_data_file = "./output/preprocess/1/Bladder_Cancer/clinical_data/GSE253531.csv"
json_path = "./output/preprocess/1/Bladder_Cancer/cohort_info.json"

# STEP1
from tools.preprocess import *

# 1. Identify the paths to the SOFT file and the matrix file
soft_file, matrix_file = geo_get_relevant_filepaths(in_cohort_dir)

# 2. Read the matrix file to obtain background information and sample characteristics data
background_prefixes = ['!Series_title', '!Series_summary', '!Series_overall_design']
clinical_prefixes = ['!Sample_geo_accession', '!Sample_characteristics_ch1']
background_info, clinical_data = get_background_and_clinical_data(
    matrix_file, 
    background_prefixes, 
    clinical_prefixes
)

# 3. Obtain the sample characteristics dictionary from the clinical dataframe
sample_characteristics_dict = get_unique_values_by_row(clinical_data)

# 4. Explicitly print out all the background information and the sample characteristics dictionary
print("Background Information:")
print(background_info)
print("Sample Characteristics Dictionary:")
print(sample_characteristics_dict)
# 1. Gene Expression Data Availability
is_gene_available = True  # Based on the series description (gene expression microarrays)

# 2. Variable Availability
trait_row = None    # No key found for "Bladder_Cancer"; also it's a constant (all have Bladder Cancer)
age_row = None      # No age data present
gender_row = None   # No gender data present

# 2.2 Data Type Conversion Functions
def convert_trait(value: str):
    # Extract substring after colon if present
    parts = value.split(':', maxsplit=1)
    raw_val = parts[1].strip() if len(parts) > 1 else parts[0].strip()
    # Since the trait is not available or is constant in this dataset, return None
    return None

def convert_age(value: str):
    return None  # No age data, return None

def convert_gender(value: str):
    return None  # No gender data, return None

# 3. Save Metadata (initial filtering)
is_trait_available = False  # Trait data is not available from the dictionary
is_usable = validate_and_save_cohort_info(
    is_final=False,
    cohort=cohort,
    info_path=json_path,
    is_gene_available=is_gene_available,
    is_trait_available=is_trait_available
)

# 4. Clinical Feature Extraction
# Skip, because trait_row is None