text_1: Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.
text_2: Notably, numerous kinetochore-microtubule (k-MT) attachment errors are present in early mitosis (prometaphase), and the persistence of those errors is the leading cause of chromosome mis-segregation in aneuploid human tumour cells that continually mis-segregate whole chromosomes and display chromosomal instability.