text_1: KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.
text_2: On the basis of in vivo KLF4 chromatin immunoprecipitation–sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target genes, including many that regulate pro-inflammatory responses of SMCs.