text_1: A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.
text_2: EVIDENCE ACQUISITION Comprehensive search of scientific publications including MEDLINE via both OVID and PubMED for relevant studies and articles with a cutoff date of July 2006, using the search terms long-term travel and malaria prevention, long-term malaria chemoprophylaxis, and insect repellent and malaria.