text_1: A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).
text_2: Individuals with SLE also have elevated serum IgE, self-reactive IgEs and activated basophils that express CD62 ligand (CD62L) and the major histocompatibility complex (MHC) class II molecule human leukocyte antigen-DR (HLA-DR), parameters that are associated with increased disease activity and active lupus nephritis.