text_1: RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.
text_2: The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting tolerance.