text_1: IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.
text_2: Studies involving yellow-fever-virus-encoded 2'O-methyltransferase and RIG-I(H830A) revealed that viruses exploit this mechanism to escape RIG-I. Our data reveal a new role for cap N1-2'O-methylation in RIG-I tolerance of self-RNA.