text_1: RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.
text_2: We show that RANKL signals from this cell promote the maturation of RANK-expressing CD80−Aire− mTEC progenitors into CD80+Aire+ mTECs, and that transplantation of RANK-deficient thymic stroma into immunodeficient hosts induces autoimmunity.