text_1: FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).
text_2: We show that in mammalian cells, the Sir2 homolog SIRT1 appears to control the cellular response to stress by regulating the FOXO family of Forkhead transcription factors, a family of proteins that function as sensors of the insulin signaling pathway and as regulators of organismal longevity.