text_1: Chenodeosycholic acid treatment reduces whole-body energy expenditure.
text_2: In rodents, BAT can be activated by bile acids, which activate type 2 iodothyronine deiodinase (D2) in BAT via the G-coupled protein receptor TGR5, resulting in increased oxygen consumption and energy expenditure. Treatment of 12 healthy female subjects with CDCA for 2 days resulted in increased BAT activity.