text_1: Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.
text_2: Traditionally, chromatin defects in the brain were considered static lesions of early development that occurred in the context of rare genetic syndromes, but it is now clear that mutations and maladaptations of the epigenetic machinery cover a much wider continuum that includes adult-onset neurodegenerative disease.