text_1: Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.
text_2: METHODS Using a genetically engineered mouse model of PDA, the authors enzymatically depleted HA by a clinically formulated PEGylated human recombinant PH20 hyaluronidase (PEGPH20) and examined tumour perfusion, vascular permeability and drug delivery.