text_1: Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.
text_2: In spite of the physical distance separating the E3 and the nucleotide-binding domains in Smc5/6, Mms21-dependent sumoylation requires binding of ATP to Smc5, a step that is part of the ligase mechanism that assists Ubc9 function.