text_1: Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.
text_2: Here we show that the SUMO ligase and the chromosome disjunction functions of Mms21 depend on its docking to an intact and active Smc5/6 complex, indicating that the Smc5/6-Mms21 complex operates as a large SUMO ligase in vivo.