text_1: New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.
text_2: In contrast, moxifloxacin, which is active in vitro against a subpopulation of Mycobacterium tuberculosis that persists in specific niches under drug pressure and has achieved treatment shortening in mice, does not diffuse well in caseum, concordant with its failure to shorten therapy in recent clinical trials.