text_1: High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).
text_2: Corresponding hazard ratios using maximum follow-up time were 1.4 (95% CI, 1.1-1.8), 1.6 (95% CI, 1.3-2.2), and 2.5 (95% CI, 1.8-3.4), respectively (trend: P = 1 × 10(-8)).