text_1: Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.
text_2: Previous DSB-mapping studies have used rad50S or sae2Δ mutants, which are defective in break processing, to accumulate Spo11-linked DSBs, and report large (≥ 50 kb) “DSB-hot” regions that are separated by “DSB-cold” domains of similar size.