diff --git "a/experimental_data/compositional_prompts/crosstalk.csv" "b/experimental_data/compositional_prompts/crosstalk.csv"
new file mode 100644--- /dev/null
+++ "b/experimental_data/compositional_prompts/crosstalk.csv"
@@ -0,0 +1,3475 @@
+"Pathway A","Pathway B","Pubmed Query","PMID","Crosstalk","Transcriptional","Regulation type","Molecule A","Molecule A Identifier","Molecule A Source","Molecule B","Molecule B Identifier","Molecule B Source","Species","Tissue Name","BTO ID","Condition","Sentence from paper","Additional notes","Misleading sentences"
+"Adipocytokine signaling pathway","ErbB signaling pathway","Adipocytokine ErbB","25838314","no","no","","","","","","","","","","","","","Mentions both pathways but does not say taht they interact with each other",""
+"Adipocytokine signaling pathway","ErbB signaling pathway","Adipocytokine ErbB","23817051","no","no","","","","","","","","","","","","","It is not mentioned that the pathways interact directly, but it is shown in a diagram that both pathways and the genes associated with them are targeted by the same obesity specific miRNA",""
+"Adipocytokine signaling pathway","ErbB signaling pathway","Leptin ErbB crosstalk","23228483","yes","yes","activating","LEP","P41159","UNIPROT","","","","Homo sapiens","breast cancer cell","BTO:0000150","Cancer cells","In the present study, we demonstrate that leptin by inducing Hsp90 expression enhacnes HER2 protein levels, providing a new molecular mechanism  underlying the crosstalk between leptin and HER2 signaling pathways in breast cancer cells.","The paper does mention bidirectional crosstalk between leptin and IGF-I signaling, mediated by syngergistic transactivation of of EGFR",""
+"Adipocytokine signaling pathway","ErbB signaling pathway","Leptin ErbB crosstalk","18945363","yes","unknown","unknown","LEP","P41159","UNIPROT","","","","Homo sapiens","breast cancer cell","BTO:0000150","Cancer cells","In summary, our results suggest the existence of crosstalk between HER2 and the leptin system in breast cancer","It also says that it is important that leptin could crosstalk with HER2 either through ObR, HER1, and JAK2. It also says that leptin affects the synthesis and/or function of ER-alpha, VEGF, and HER2",""
+"Adipocytokine signaling pathway","ErbB signaling pathway","Adpocytokine EGFR crosstalk","19047149","no","no","","","","","","","","","","","","","The paper mentions crosstalk between leptin and IGF-I which transactivates EGFR, but no direct crosstalk between leptin and EGFR",""
+"Adipocytokine signaling pathway","Estrogen signaling pathway","Adipocytokine Estrogen crosstalk","20410173","yes","no","activating","LEPR","P48357","UNIPROT","ESR1","P03372","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","Cancer cells","These observations support the notion that there is a general crosstalk between leptin and estrgoens that show widely overlapping effects in terms of metabolic and molecular actions.","The paper focuses mainly on the interaction between LepR and ER alpha. It was shown that LepR neutralization or LepR gene silencing in ER-positive breast cancer cells caused a significant reduction in the ER-alpha expression",""
+"Adipocytokine signaling pathway","Estrogen signaling pathway","Leptin Estrogen crosstalk","23357303","yes","unknown","unknown","LEP","P41159","UNIPROT","ESR1/ESR2","P03372/Q92731","UNIPROT","Homo sapiens","chondrocyte","BTO:0000249","chodrocyte differentiation","The crosstalk between leptin and estrogen resceptor was differentiation stage specific","Many times in the paper it said that there was crosstalk between leptina nd estrogen, but it also said many times that the role of the crosstalk in chondrocyte differentiation was unknown",""
+"Adipocytokine signaling pathway","Estrogen signaling pathway","Leptin Estrogen crosstalk","22178935","yes","unknown","activating","LEP","P41159","UNIPROT","ESR1/ESR2","P03372/Q92731","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","Cancer cells","The study supports the existence of a crosstalk between leptin and estrogen, in which leptin might play an important role potentiating ht mitogenic action o festrogen, probably by alteration of ERalpha to ERbeta ratio","The full paper was unavailable, so this information is only from the abstract",""
+"Adipocytokine signaling pathway","Estrogen signaling pathway","Leptin Estrogen crosstalk","22135239","yes","unknown","activating","LEP","P41159","UNIPROT","ESR1","P03372","UNIPROT","Homo sapiens","chondrocyte","BTO:0000249","gene expression in chondrocytes","Binai et al. [2009] demonstrated that ERalpha stimulated the leptin-mediated STAT3 in the cytoplasm in breast cancer cells indpepndent of ERalpha ligands, underlying a srosstalk between leptin stimulation and ERalpha expression","Crosstalk is a little unclear since this sentence mentions a mediator",""
+"Adipocytokine signaling pathway","GnRH signaling pathway","Adipocytokine GnRH pathway","19662887","no","no","","","","","","","","","","","","","The full text was not available, and the only information in the abstract was that leptin can stimulate the release of GnRH",""
+"Adipocytokine signaling pathway","GnRH signaling pathway","leptin GnRH crosstalk","25118207","no","no","","","","","","","","","","","","","The text says that leptin and GnRH do not interact directly, but that there is an intermediate, most likely KNDy neurons",""
+"Adipocytokine signaling pathway","GnRH signaling pathway","leptin GnRH crosstalk","11750723","no","no","","","","","","","","","","","","","The text indicates that there is a positive relationship between leptin and the release of gonadotropin, but there is no evidence to support that the two pathways crosstalk",""
+"Adipocytokine signaling pathway","GnRH signaling pathway","leptin GnRH pathway","25575434","no","no","","","","","","","","","","","","","The text states that leptin is important in controlling GnRH release, and that leptin stimulates GnRH release, but that the most likely mechanism of this is through neuronal intermediates",""
+"Adipocytokine signaling pathway","GnRH signaling pathway","leptin GnRH pathway","24829217","no","no","","","","","","","","","","","","","The paper says that leptin has an indirect interaction with GnRH neurons, and that the stimulatory effects on leptin were conveyed indirectly to GnRH neurons via other neural components within the GnRH neuronal network.",""
+"Adipocytokine signaling pathway","GnRH signaling pathway","leptin GnRH pathway","24198376","no","no","","","","","","","","","","","","","The paper mentions many ways through which the signal from leptin to GnRH is mediated, but never provides any support that they directly crosstalk",""
+"Adipocytokine signaling pathway","GnRH signaling pathway","leptin GnRH pathway","22980196","no","no","","","","","","","","","","","","","The paper explains and diagrams that leptin is a key part of reproduction, especially in females, but that there are intermediates in the signaling of GnRH by leptin, including kisspeptin neurons",""
+"Adipocytokine signaling pathway","GnRH signaling pathway","leptin GnRH pathway","24612072","no","no","","","","","","","","","","","","","The paper explains that while leptin has a strong impact on GnRH release, it doesn not directly act on GnRH neurons, and no leptin receptors have been found on any GnRH neurons. There is ongoing investigation as to all the potential intermediates in this pathway",""
+"Adipocytokine signaling pathway","GnRH signaling pathway","leptin GnRH pathway","23550015","no","no","","","","","","","","","","","","","The paper deals more with kisspeptin, but mentions that Kiss1 neurons are likely to submit metabolic information from leptin to GnRH neurons",""
+"Adipocytokine signaling pathway","GnRH signaling pathway","leptin GnRH pathway","14576185","no","no","","","","","","","","","","","","","The paper states that the leptin receptor has not been detected on GnRH neurons invivo, suggesting that leptin's actions of GnRH release are not direct",""
+"Adipocytokine signaling pathway","HIF-1 signaling pathway","leptin HIF-1 pathway","25312721","no","no","","","","","","","","","","","","","The paper suggested that leptin is regulated by HIF-1alpha, which is a protein in the HIF-1 pathway. The paper does not specify if this regulation is direct or what specific interactions the two pathways have, so crosstalk was unclear",""
+"HIF-1 signaling pathway","Adipocytokine signaling pathway","leptin HIF-1 pathway","21252047","no","no","","","","","","","","","","","","","The text states that leptin activates HIF-1alpha, but it does not specify how, although there is a diagram (figure 11) which suggestst that there are intermediates",""
+"Adipocytokine signaling pathway","HIF-1 signaling pathway","leptin HIF-1 pathway","24466027","no","no","","","","","","","","","","","","","The paper says that leptin gene expression is regulated by HIF-1, which could indicate transcriptional crosstalk, but it does not say that the effect is direct, so it is unsure whether there is crosstalk",""
+"Adipocytokine signaling pathway","HIF-1 signaling pathway","leptin HIF-1 pathway","21145207","no","no","","","","","","","","","","","","","The paper says that the human leptin gene is induced by hypoxia through HIF-1, which supports that the two pathways don't interact directly",""
+"Adipocytokine signaling pathway","HIF-1 signaling pathway","leptin HIF-1 pathway","24819450","no","no","","","","","","","","","","","","","It is stated in the paper that leptin is augmented under hypoxic conditions, but it does not say that HIF-1 is directly involved",""
+"Adipocytokine signaling pathway","HIF-1 signaling pathway","leptin HIF-1 pathway","12084725","yes","yes","","","","","","","","","","","","Taken together, these observations indicate that transcription of the leptin gene is stimulated by hypoxia through a mechanism that involves bonding of heterodimeric HIF1alpha/beta to the proximal HRE site lcoated at -116 within the leptin gene promoter","None",""
+"Adipocytokine signaling pathway","HIF-1 signaling pathway","leptin HIF-1 pathway","21814490","no","no","","","","","","","","","","","","","In the paper it says that hypothalamic HIF was responsive to glucose but not leptin, which aligns with the observation that hypothalamic glucose sensing did not involve the induction of leptin signaling",""
+"Adipocytokine signaling pathway","HIF-1 signaling pathway","leptin HIF-1 pathway","14513066","no","no","","","","","","","","","","","","","The full text was unavailable, but based on the abstract it mentions no direct effect of either pathway on the other",""
+"Adipocytokine signaling pathway","HIF-1 signaling pathway","leptin HIF-1 pathway","18206644","no","no","","","","","","","","","","","","","The text explains that hypoxiaoccurs in white adipose tissue in obesity, an that in these cases HIF1alpha and leptin are increased, but does not mention any direct interactions",""
+"Adipocytokine signaling pathway","Hippo signaling pathway","leptin hippo pathway","21720710","no","no","","","","","","","","","","","","","The text didn't actually mention anything about the hippo pathway, but one of the authors had a last name of Hippo",""
+"Adipocytokine signaling pathway","Hippo signaling pathway","leptin hippo pathway","24958593","no","no","","","","","","","","","","","","","The text never mentioned anything about the hippo pathway",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","adipocytokine insulin crosstalk","22876924","no","no","","","","","","","","","","","","","The article mentioned crosstalk between the liver and adipose tissue, but not any direct crosstalk between the pathways",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","adipocytokine insulin crosstalk","19047149","no","no","","","","","","","","","","","","","The paper mentions bidirectional crosstalk between leptin and IGF-I signaling, but not leptin and insulin",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","adipocytokine insulin crosstalk","12379502","yes","unknown","inhibiting","LEP","P41159","UNIPROT","","","","Homo sapiens","adipocyte","BTO:0000443","normal","This is the first report on direct leptin interactions with insulin signalling and action in brown adipocytes","The paper notes that leptin impairs insulin-induced glucose uptake, and inhibits important proximal insulin-signalling elements",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","adipocytokine insulin crosstalk","14671216","no","no","","","","","","","","","","","","","The study performed dealt more with a commercially available ELISA kit for human resistin and examined circulating levels of resistin in ondiabetic and type 2 diabetic subjects",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","adipocytokine insulin crosstalk","19183933","no","no","","","","","","","","","","","","","The study mainly focuses on the interaction of CD40 signalling pathways in relation to adipcytokine and insuling seperately, rather than adipocytokine with insulin",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","adipocytokine insulin crosstalk","23281828","no","no","","","","","","","","","","","","","The paper only very briefly mentions adipocytokine and mainly deals with the role of different insuling pathways in Type II Diabetes",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","adipocytokine insulin crosstalk","23369358","yes","unknown","unknown","LEP","P41159","UNIPROT","insulin","Other","Other","Homo sapiens","hypothalamus","BTO:0000614","SCZ/T2D","In our constructed STMN, we also observed a crosstalk between leptin and insulin in the hypothalamus","The paper deals with the crosstalk between many pathways that may interact to show that that SCZ and T2D also interact, but only briefly mentions that leptin and insulin crosstalk directly, and also shows a diagram that connects the 2 pathways, which show that they crosstalk",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","adipocytokine insulin pathway","24604418","no","no","","","","","","","","","","","","","The paper discusses the effect of RBP4 (an adipocytokine on insulin-induced proliferationof RASMCs, and says that RBP4 enhances RASMC proliferation iinduced by insulin via activation of the MAPK signaling pathway, which suggests they don't directly interact",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","adipocytokine insulin pathway","23011062","no","no","","","","","","","","","","","","","The article deals with different genes that have a role in insulin and adipocytokine signaling, and there were a few genes that had a role in both, but it does not mention any direct interaction between the two pathways",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","adipocytokine insulin pathway","26019302","no","no","","","","","","","","","","","","","The full text was unavailable, and the abstract makes no mention of any interaction between the two pathways",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","adipocytokine insulin pathway","25657638","no","no","","","","","","","","","","","","","The article makes no mention of any direct interactions between the two pathways",""
+"MAPK signaling pathway","Neurotrophin signaling pathway","MAPK Neurotrophin crosstalk","25055025","no","no","","","","","","","","","","","","","Only the abstract was available, and it mentions convergence between the two pathways, but does not give any evidence that they directly crosstalk",""
+"MAPK signaling pathway","Neurotrophin signaling pathway","MAPK Neurotrophin pathway","23595279","no","no","","","","","","","","","","","","","The text states that BDNF (a neurotrophin) activates the TrkB-ERK/MAPK pathway and inhibits apoptosis, but later states that the mechanism of this needs further studies",""
+"MAPK signaling pathway","Neurotrophin signaling pathway","MAPK Neurotrophin pathway","22449548","no","no","","","","","","","","","","","","","The text makes no mention that the pathways interact directly, only that they are related",""
+"MAPK signaling pathway","Neurotrophin signaling pathway","MAPK Neurotrophin pathway","23772401","no","no","","","","","","","","","","","","","The article only talks about the effect of LCP on MAPK, but does mention that MAPK can be induced by NGF, but it does not say how",""
+"MAPK signaling pathway","Neurotrophin signaling pathway","MAPK Neurotrophin pathway","24639488","no","no","","","","","","","","","","","","","The article makes no mention of any direct interaction between the two pathways",""
+"MAPK signaling pathway","Neurotrophin signaling pathway","MAPK Neurotrophin pathway","24529757","no","no","","","","","","","","","","","","","The article discusses crosstalk of many pathways but does not give clear evidence that MAPK and neurotrophin crosstalk. There is a diagram that suggests that they do crosstalk, but it is unclear.",""
+"MAPK signaling pathway","Neurotrophin signaling pathway","MAPK Neurotrophin","23065828","no","no","","","","","","","","","","","","","The article does not mention any crosstalk between the two pathways",""
+"MAPK signaling pathway","Neurotrophin signaling pathway","MAPK Neurotrophin pathway","21097678","no","no","","","","","","","","","","","","","The paper mentions that the two are related and have an effect on each other, but not that they interact directly",""
+"MAPK signaling pathway","Neurotrophin signaling pathway","MAPK Neurotrophin pathway","21383773","yes","unknown","unknown","","","","","","","Homo sapiens","brain","BTO:0000142","bipolar patients","Neurotrophin signaling interacts with downstream pathways including MAPK, which in turn, maintains crosstalk with other significantly enriched pathways, including Wnt, apoptosis, ErbB, and insulin","The paper only briefly mentions that they interact, but since it states explicitly that the pathways interact, it is most likely that they do",""
+"MAPK signaling pathway","Neurotrophin signaling pathway","MAPK Neurotrophin pathway","20300619","no","no","","","","","","","","","","","","","The paper states that the two have some kind of effect on each other, but it does not provide clear evidence that the two are directly involved",""
+"TNF signaling pathway","MAPK signaling pathway","MAPK TNF crosstalk","23812841","no","no","","","","","","","","","","","","","The paper explains and diagrams that TNF does have an effect on MAPK, but it expalins that the effect acts through NFkB, and is not direct",""
+"MAPK signaling pathway","TNF signaling pathway","MAPK TNF crosstalk","24080497","no","no","","","","","","","","","","","","","The paper mentions crosstalk between DUSP1 and NFkB, but not between MAPK and TNF",""
+"MAPK signaling pathway","TNF signaling pathway","MAPK TNF crosstalk","23226236","no","no","","","","","","","","","","","","","The text says that p38 plays a crucial role in the production of TNF-alpha, but it does not state the mechanism for this. The article is about crosstalk between MAPK and G-protein, and it is said that TNF-alpha has a GPCR as a receptor, but it says it is not a classic GPCR, and the article does not say if MAPK crosstalks with this or not",""
+"MAPK signaling pathway","TNF signaling pathway","MAPK TNF crosstalk","23818055","no","no","","","","","","","","","","","","","The article only mentions crosstalk between MAPK and Wnt, but no crosstalk between MAPK and TNF",""
+"MAPK signaling pathway","TNF signaling pathway","MAPK TNF crosstalk","25722974","no","no","","","","","","","","","","","","","The article discusses crosstalk between MAPK and other pathways, but not MAPK and TNF. It does mention that TNF-alpha plays a role, but it does not clarify what that role is",""
+"MAPK signaling pathway","TNF signaling pathway","MAPK TNF crosstalk","23960234","no","no","","","","","","","","","","","","","The paper gives no solid evidence of any crosstalk between the 2 pathways",""
+"MAPK signaling pathway","TNF signaling pathway","MAPK TNF crosstalk","23932046","no","no","","","","","","","","","","","","","The paper gives no solid evidence of any crosstalk between the 2 pathways",""
+"MAPK signaling pathway","TNF signaling pathway","MAPK TNF crosstalk","19043087","no","no","","","","","","","","","","","","","The paper discusses crosstalk between the various MAPK cascades(ERK1/2, JNK, and p38), and mentions TNF-alpha expression being suppressed, bu tnot any direct interaction between the two pathways",""
+"MAPK signaling pathway","TNF signaling pathway","MAPK TNF crosstalk","23994140","no","no","","","","","","","","","","","","","The article heavily discusses crosstalk, but is very unclear and hard to follow. It mentions MAPK crosstalk points, and mentions that TNF can be regulated by crosstalk points, but does not specify the crosstalk points being referred to. There is a diagram that suggests crosstalk, but it is very elementary and poorly narrated.",""
+"Estrogen signaling pathway","GnRH signaling pathway","Estrogen GnRH Crosstalk","19490993","no","no","","","","","","","","","","","","","The article focuses more on the effect of TCDD on estrogen and GnRH separately, as opposed to how they interact with each other",""
+"Estrogen signaling pathway","GnRH signaling pathway","Estrogen GnRH Crosstalk","3935863","no","no","","","","","","","","","","","","","The full text was unavailable, and the abstract makes no mention of any interaction between GnRH and estrogen",""
+"Estrogen signaling pathway","GnRH signaling pathway","Estrogen GnRH Crosstalk","15140796","no","no","","","","","","","","","","","","","The text does not mention any direct interaciton between and estrogen and GnRH",""
+"Estrogen signaling pathway","GnRH signaling pathway","Estrogen GnRH Crosstalk","1090433","no","no","","","","","","","","","","","","","The full text was unavailable, and the abstract makes no mention of any interaction between GnRH and estrogen",""
+"Estrogen signaling pathway","GnRH signaling pathway","Estrogen GnRH Crosstalk","6435222","no","no","","","","","","","","","","","","","The full text was unavailable and the abstract does not even mention GnRH or estrogen",""
+"Estrogen signaling pathway","GnRH signaling pathway","Estrogen GnRH Crosstalk","772693","no","no","","","","","","","","","","","","","The full text was unavailable, and the abstract makes no mention of GnRH, and only once mentions estrogen",""
+"Estrogen signaling pathway","GnRH signaling pathway","Estrogen GnRH Crosstalk","10655292","no","no","","","","","","","","","","","","","The text only barely mentions estrogen, and does not suggest any interaction between estrogen and GnRH",""
+"Estrogen signaling pathway","GnRH signaling pathway","Estrogen GnRH Crosstalk","6436700","no","no","","","","","","","","","","","","","The full text was unavailable and the abstract does not even mention GnRH or estrogen",""
+"Estrogen signaling pathway","GnRH signaling pathway","Estrogen GnRH Crosstalk","6790400","no","no","","","","","","","","","","","","","The full text was unavailable, and the the abstract only mentioned GnRH, not estrogen",""
+"Estrogen signaling pathway","GnRH signaling pathway","Estrogen GnRH Crosstalk","18571346","no","no","","","","","","","","","","","","","The text explains that GnRH signals LH and FSH, which signal estrogen, but GnRH does not have any direct interaction with estrogen",""
+"Estrogen signaling pathway","GnRH signaling pathway","Estrogen GnRH Crosstalk","1101389","no","no","","","","","","","","","","","","","The full text was unavailable, and the abstract only mentions GnRH and does not mention estrogen",""
+"GnRH signaling pathway","MAPK signaling pathway","MAPK GnRH Crosstalk","22922893","no","no","","","","","","","","","","","","","The article mentions negative interactions between the tumor cell analogs of GnRH I/II and EGFR/MAPK, but it doesn't say that GnRH itself interacts with MAPK",""
+"GnRH signaling pathway","MAPK signaling pathway","MAPK GnRH Crosstalk","11358118","no","no","","","","","","","","","","","","","The full text was not available, but the abstract does mention that GnRH activates MAPK, but it does not say how. It also mentions crosstalk between other different pathways, but not specifically with GnRH and MAPK",""
+"GnRH signaling pathway","MAPK signaling pathway","MAPK GnRH Pathway","24912407","no","no","","","","","","","","","","","","","The article says that both pathways help to regulate glucose metabolism in the intestine, but does not say that they interact with each other",""
+"GnRH signaling pathway","MAPK signaling pathway","MAPK GnRH Pathway","21846488","yes","no","activating","Gnrh1","P13562","UNIPROT","Mapk3/Mapk1","Q63844/P63085","UNIPROT","Mus musculus","LbetaT2 cell","BTO:0004467","Treatment with BMPs","As shown in Fig. 3A, 10 and 100 nM or GnRH readily activated phosphorylation of ERK1/2, p38-MAPK, and SAPK/JNK pathways","The article explains that GnRH activates the MAPK pathways by phosphorylation",""
+"GnRH signaling pathway","MAPK signaling pathway","MAPK GnRH Pathway","20507982","no","no","","","","","","","","","","","","","The article does not give clear evidence that the two pathways are directly linked",""
+"GnRH signaling pathway","MAPK signaling pathway","MAPK GnRH Pathway","24085820","yes","no","activating","GNRHR","P30968","UNIPROT","","","","Homo sapiens","hypophysis","BTO:0001073","GnRH applied in pulsatile manner","In general, the expression of these transcriptional regulators depends on the MAPK signaling pathway activated by GnRHR and is critical in the control of the expression of four major genes by gondaotrophs: Cga, Lhb, Fshb, and Gnrhr.","The article states many times that the two pathways interact",""
+"GnRH signaling pathway","MAPK signaling pathway","MAPK GnRH Pathway","22775470","no","no","","","","","","","","","","","","","The article says that both are related, but says that GnRH-induced events trigger the MAPK cascades, not that GnRH itself does",""
+"GnRH signaling pathway","MAPK signaling pathway","MAPK GnRH Pathway","20181617","no","no","","","","","","","","","","","","","The article does not give clear evidence that the two pathways are directly linked",""
+"MAPK signaling pathway","Wnt signaling pathway","MAPK Wnt Crosstalk","25312291","yes","unknown","unknown","[MAPK8/MAPK9]","[P45983/P45984]","UNIPROT","WNT5A","P41221","UNIPROT","Homo sapiens","cartilage","BTO:0000206","cartilage inflammation","Because the loss of a differentiated phenotype of chondrocytes is associated with cartilage destruction during arthritis, the canonical Wnt pathway-mediated  cell phenotype change via crosstalk with MAPK signals is another pathway through which OA forms","The article is mainly about Wnt MAPK crosstalk and provides lots of evidence that they do",""
+"MAPK signaling pathway","Wnt signaling pathway","MAPK Wnt Crosstalk","23818055","yes","unknown","unknown","[MAPK11/MAPK14]","[Q15759/Q16539]","UNIPROT","CTNNB1","P35222","UNIPROT","Homo sapiens","dental papilla","","effect of LPS in SCAP","Growing evidence supports the notion of crosstalk between the p38 MAPK and Wnt/beta-catenin signalling pathways","The article doesn't provide a lot of background as to how the two pathways crosstalk, but it does state explicitely that they do",""
+"MAPK signaling pathway","Wnt signaling pathway","MAPK Wnt Crosstalk","23657601","no","no","","","","","","","","","","","","","The article mainly focuses on TGFbeta and Wnt crosstalk, and mentions that their crosstalk leads to phosphorylation of p-44/42 MAPK, but does not say how",""
+"Wnt signaling pathway","MAPK signaling pathway","MAPK Wnt Crosstalk","22494969","yes","no","activating","CTNNB1","P35222","UNIPROT","RRAS","P10301","UNIPROT","Homo sapiens","colon","BTO:0000269","cancerous cells","In contrast, in colorectal cancer, stiumlation of the Wnt/beta-catenin pathway leads to activation of the MAPK pathway through Ras stabilization, representing an example of positive crosstalk","The article mentions a lot of direct crosstalk between the two pathways",""
+"MAPK signaling pathway","Wnt signaling pathway","MAPK Wnt Crosstalk","22494969","yes","no","inhibiting","","","","AXIN1","O15169","UNIPROT","Homo sapiens","skin","BTO:0001253","melanoma","Indeed, in melanoma, hyperactivated MAPK signaling down-regulates the Wnt/beta-catenin signal transduction cascade, thereby establishin a negative crossstalk between the two signaling pathways","The article mentions a lot of direct crosstalk between the two pathways",""
+"Wnt signaling pathway","MAPK signaling pathway","MAPK Wnt Crosstalk","22796649","yes","no","activating","gsk3b","Q9YH60","UNIPROT","mapk1/mapk3","Q6P023/Q7ZVK8","UNIPROT","Danio rerio","tail bud","BTO:0001445","tail formation","Phosphorylation of Gsk3beta also leads to an increase in active Erk levels, suggesting Wnt signaling promotes Mapk activity","The article is mainly about crosstalk between Fgf and Wnt through Erk, but Fgf is part of the MAPK signaling pathway",""
+"MAPK signaling pathway","Wnt signaling pathway","MAPK Wnt Crosstalk","22796649","yes","yes","activating","","","","","","","Danio rerio","tail bud","BTO:0001445","tail formation","Fgf signaling inhibits transcription of the Wnt inhibitors dkk1 and notum1a","Since Fgf is part of the MAPK pathway, they are considered to crosstalk",""
+"MAPK signaling pathway","Wnt signaling pathway","MAPK Wnt Crosstalk","24816560","yes","no","","","","","GSK3B","P49841","UNIPROT","Homo sapiens","epithelial cell","BTO:0000414","normal","","",""
+"Hippo signaling pathway","Wnt signaling pathway","Hippo Wnt Crosstalk","24846937","yes","unknown","unknown","YAP1","P46937","UNIPROT","CTNNB1","P35222","UNIPROT","Homo sapiens","acute lymphoblastic leukemia cell","BTO:0000731","cancerous tumors","We discuss on the interactions between Wnt/beta-catenin and Hippo/YAP pathways","The full text was unavailable nut the abstract explicitely states that the two crosstalk",""
+"Hippo signaling pathway","Wnt signaling pathway","Hippo Wnt Crosstalk","25470458","yes","no","activating","YAP1/WWTR1","P46937/Q9GZV5","UNIPROT","CTNNB1","P35222","UNIPROT","Homo sapiens","lung","BTO:0000763","lung development","One prime example of such crosstalk has already been briefly described above with the incorporation of cytoplasmic YAP/TAZ in the desctruction complex, where they are essential for beta-catenin as well as TAZ degradation by recruiting beta-TrCP","The text states explicitely and describes in depth the crosstalk between Wnt and Hippo",""
+"Hippo signaling pathway","Wnt signaling pathway","Hippo Wnt Crosstalk","25470458","no","yes","activating","YAP1/WWTR1","P46937/Q9GZV5","UNIPROT","[TEAD1/TEAD2/TEAD3/TEAD4]","[P28347/Q15562/Q99594/Q15561]","UNIPROT","Homo sapiens","lung","BTO:0000763","lung development","YAP/TAZ/TEAD-mediated gene expression is an integral part of the Wnt transcriptional response","The text states explicitely and describes in depth the crosstalk between Wnt and Hippo",""
+"Hippo signaling pathway","Adherens junction","Hippo Wnt Crosstalk","25470458","yes","no","activating","YAP1/WWTR1","P46937/Q9GZV5","UNIPROT","CTNNA1","P35221","UNIPROT","Homo sapiens","lung","BTO:0000763","lung development","Phosphorylated YAP interacts with alpha-catenin via 14-3-3 proteins and alpha catenin deletion is sufficient to shift YAP to the nucleus and induce squamos cell carcinomas in the skin","The text states explicitely and describes in depth the crosstalk between Wnt and Hippo, Sarah: YAP interacting with alpha catenin (adherens junction)",""
+"Hippo signaling pathway","Wnt signaling pathway","Hippo Wnt Crosstalk","23607968","yes","yes","unknown","YAP1/WWTR1","P46937/Q9GZV5","UNIPROT","[TEAD1/TEAD2/TEAD3/TEAD4]","[P28347/Q15562/Q99594/Q15561]","UNIPROT","Homo sapiens","epithelium","BTO:0000416","development/homeostatic epithelial tissue","Two pathways known to be important for epithelial development and homeostasis are the Wnt and Hippo pathways and there is accumulating evidence that the Hippo cascade engages in crosstalk with Wnt signaling in epithelial tissues","The text states explicitely and describes in depth the crosstalk between Wnt and Hippo",""
+"Hippo signaling pathway","Wnt signaling pathway","Hippo Wnt Crosstalk","23792172","yes","no","inhibiting","YAP1/WWTR1","P46937/Q9GZV5","UNIPROT","[DVL1/DVL2/DVL3]","[O14640/O14641/Q92997]","UNIPROT","Homo sapiens","eye","BTO:0000439","ocular health/disease","YAP/TAZ can inhibit Wnt signaling through inhibition of Dvl in the cytoplasm(TAZ) or in the nucleus(YAP) or sytoplasmic separation of beta-catenin (YAP)","The text states explicitely and describes in depth the crosstalk between Wnt and Hippo",""
+"Hippo signaling pathway","Wnt signaling pathway","Hippo Wnt Crosstalk","23792172","yes","no","inhibiting","YAP1/WWTR1","P46937/Q9GZV5","UNIPROT","CTNNB1","P35222","UNIPROT","Homo sapiens","eye","BTO:0000439","ocular health/disease","YAP/TAZ can inhibit Wnt signaling through inhibition of Dvl in the cytoplasm(TAZ) or in the nucleus(YAP) or sytoplasmic separation of beta-catenin (YAP)","The text states explicitely and describes in depth the crosstalk between Wnt and Hippo",""
+"Hippo signaling pathway","Wnt signaling pathway","Hippo Wnt Crosstalk","23792172","yes","yes","activating","YAP1","P46937","UNIPROT","[DVL1/DVL2/DVL3]","[O14640/O14641/Q92997]","UNIPROT","Homo sapiens","eye","BTO:0000439","ocular health/disease","YAP/TAZ can inhibit Wnt signaling through inhibition of Dvl in the cytoplasm(TAZ) or in the nucleus(YAP) or sytoplasmic separation of beta-catenin (YAP)","The text states explicitely and describes in depth the crosstalk between Wnt and Hippo",""
+"Hippo signaling pathway","Wnt signaling pathway","Hippo Wnt Crosstalk","23792172","yes","no","inhibiting","YAP1","P46937","UNIPROT","CTNNB1","P35222","UNIPROT","Homo sapiens","eye","BTO:0000439","ocular health/disease","Alternatively, YAP can encourages the transcriptional activity of beta-catenin","The text states explicitely and describes in depth the crosstalk between Wnt and Hippo, Sarah: Hippo signaling inactivates YAP so change to negative",""
+"Wnt signaling pathway","HIF-1 signaling pathway","Wnt HIF-1 Crosstalk","23358852","yes","no","activating","CTNNB1","P35222","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","epithelial cell","BTO:0000414","hepatocellular carcinoma","This work shows that beta-catenin forms a complex with hif-1alpha, thereby increasing transcriptional activity of hif-1alpha","The text is clear that these two pathways crosstalk",""
+"Wnt signaling pathway","HIF-1 signaling pathway","Wnt HIF-1 Crosstalk","23358852","yes","no","activating","CTNNB1","P35222","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","mesenchymal cell","BTO:0002625","hepatocellular carcinoma","This work shows that beta-catenin forms a complex with hif-1alpha, thereby increasing transcriptional activity of hif-1alpha","The text is clear that these two pathways crosstalk",""
+"Wnt signaling pathway","HIF-1 signaling pathway","Wnt HIF-1 Crosstalk","24070739","no","no","","","","","","","","","","","","","The text explains crosstalk between other signaling pathways, but not wnt and HIF-1",""
+"HIF-1 signaling pathway","Wnt signaling pathway","Wnt HIF-1 Crosstalk","23429286","yes","no","activating","hif1ab","Q6EHI4","UNIPROT","elk4/lef1","Q9PU63/Q9W7C0","UNIPROT","Danio rerio","glioblastoma cell line","BTO:0001530","hypoxia","HIF1-alpha enhances the expression of the beta-catenin co-factors TCF-1 and LEF-1 in embryonic NSCs, thus promoting beta-catenin-dependent Wnt signaling activity","The text is clear that these two pathways crosstalk",""
+"Wnt signaling pathway","TNF signaling pathway","Wnt TNF Crosstalk","23818055","no","no","","","","","","","","","","","","","The text explains crosstalk between MAPK and Wnt, but not Wnt and TNF",""
+"Wnt signaling pathway","TNF signaling pathway","Wnt TNF Crosstalk","21973075","no","no","","","","","","","","","","","","","The text does not mention any direct interaction between the two pathways",""
+"Wnt signaling pathway","TNF signaling pathway","Wnt TNF Crosstalk","24814920","yes","unknown","unknown","CTNNB1","P35222","UNIPROT","TNF","P01375","UNIPROT","Homo sapiens","gut","BTO:0000545","IBD","These findings indicate that CDX2 is involved in the crosstalk between TNF-alpha and the Wnt signaling pathway","The text explicitely states that the two pathways crosstalk",""
+"Wnt signaling pathway","TNF signaling pathway","Wnt TNF Crosstalk","23029025","no","no","","","","","","","","","","","","","The text does not mention any direct interaction between the two pathways",""
+"Wnt signaling pathway","TNF signaling pathway","Wnt TNF Crosstalk","20706670","no","no","","","","","","","","","","","","","The text states that the two act independently, at least in this context.",""
+"Wnt signaling pathway","TNF signaling pathway","Wnt TNF Crosstalk","22886298","no","no","","","","","","","","","","","","","The paper says that both might contribute to cutaneous scarring, but not that they interact with each other",""
+"Wnt signaling pathway","TNF signaling pathway","Wnt TNF Crosstalk","14592850","no","no","","","","","","","","","","","","","The paper does not provide any evidence that the two crosstalk",""
+"Wnt signaling pathway","NF-kappa B signaling pathway","NF-kappa B Wnt Crosstalk","22160170","yes","no","inhibiting","GSK-3beta","Other","Other","IkB","Other","Other","Mesocricetus auratus","buccal mucosa cancer cell","BTO:0005769","HBP carcinogenesis","The results of the present study also suggest a functional crosstalk between Wnt and NF-kB signaling pathways in HBP carcinomas that is blocked by dietary ellagic acid","The paper also mentions that GSK-3beta blacks NF-kB activation by preventing the degradation of IkB",""
+"NF-kappa B signaling pathway","Wnt signaling pathway","NF-kappa B Wnt Crosstalk","21035559","yes","no","activating","IL1B","P01584","UNIPROT","WNT5A","P41221","UNIPROT","Homo sapiens","chondrocyte","BTO:0000249","cartilage destruction/athritis","In conclusion, we have shown that the induction of Wnt-5A expression by IL-1beta is through the NF-kB signaling pathways","The paper states explicitely that the two crosstalk",""
+"HIF-1 signaling pathway","Wnt signaling pathway","NF-kappa B Wnt Crosstalk","21502812","yes","yes","activating","HIF1A","Q16665","UNIPROT","APC","P25054","UNIPROT","Homo sapiens","HCT-116 cell","BTO:0001109","osteosarcoma; hypoxia","We discovered a hypoxia-responsive element (HRE) in the APC promoter and demonstrated that hypoxia induces HIF-1α binding to this site.","APC controls amounts of free beta-catenin so downregulation of APC would decrease Wnt signaling.",""
+"Wnt signaling pathway","NF-kappa B signaling pathway","NF-kappa B Wnt Crosstalk","21901818","no","no","","","","","","","","","","","","","The paper does not mention any specific crosstalk between Wnt and NFkB",""
+"Wnt signaling pathway","NF-kappa B signaling pathway","NF-kappa B Wnt Crosstalk","16407823","yes","no","unknown","GSK3B","P49841","UNIPROT","","","","Homo sapiens","acute myeloid leukemia cell","BTO:0001545","AML, resistance to therapy","We propose that active GSK3beta could represent a new pathway responsible for NF-kB activation in AML","The paper states explicitely that the two crosstalk",""
+"Wnt signaling pathway","NF-kappa B signaling pathway","NF-kappa B Wnt Crosstalk","21531130","no","no","","","","","","","","","","","","","The paper does not mention any specific crosstalk between Wnt and NFkB",""
+"Wnt signaling pathway","NF-kappa B signaling pathway","NF-kappa B Wnt Crosstalk","14592850","yes","no","activating","BTRC","Q9Y297","UNIPROT","[NFKBIA/NFKBIB]","[P25963/Q15653]","UNIPROT","Homo sapiens","vascular smooth muscle cell","BTO:0004578","normal","We have identified a role for the E3 ligase, beta-TrCP, in the regulation of IkB degradation and NF-kB activation in VSMCs","",""
+"Wnt signaling pathway","TGF-beta signaling pathway","Wnt TGF-beta Crosstalk","24167144","yes","no","unknown","","","","","","","Homo sapiens","embryo","BTO:0000379","normal","Researches find several typical cross points between these two signaling systems","The full text was unavailable but the abstract states that the two pathways crosstalk",""
+"Wnt signaling pathway","TGF-beta signaling pathway","Wnt TGF-beta Crosstalk","25955104","yes","no","unknown","","","","","","","Homo sapiens","colon","BTO:0000269","cancer","Our results demonstrate that FOXQ1 plays a critical role during the tumorigenesis of colorectal cancer and is a mediator of the crosstalk between Wnt and TGF-beta","The full text was unavailable but the abstract states that the two pathways crosstalk",""
+"Wnt signaling pathway","TGF-beta signaling pathway","Wnt TGF-beta Crosstalk","24003087","yes","no","unknown","","","","","","","Homo sapiens","reticulum trabeculare","BTO:0001605","glaucoma","Possible crosstalk of TGF-beta2 and Wnt signaling pathways in the TM deserves further investigation","The paper provides lots of evidence that the two pathways crosstalk, but does not clearly explain how",""
+"Wnt signaling pathway","TGF-beta signaling pathway","Wnt TGF-beta Crosstalk","23576364","yes","no","unknown","","","","","","","Homo sapiens","mesenchymal stem cell","BTO:0003298","embryonic cartilage development","This narrative review attempts to define current knowledge on the crosstalk between FGF, TGF-beta, and Wnt signaling","The full text was unavailable but the abstract states that the two pathways crosstalk",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","Neurotrophin Toll-like Receptor Pathway","24821721","no","no","","","","","","","","","","","","","The text does not mention any interaction between neurotrophin and toll like receptor pathways",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","Neurotrophin Toll-like Receptor Pathway","24082036","yes","no","unknown","S100B","P04271","UNIPROT","TLR4","O00206","UNIPROT","Homo sapiens","colon","BTO:0000269","inflammation","This neurotrophin promotes macrophage recruitment in the mucosa, amplify colonic inflammation, and interacts with toll-like receptors","The text mentions that the two interact, but it does not say how",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","Neurotrophin Toll-like Receptor Pathway","24662564","no","no","","","","","","","","","","","","","The text mentions an interaction between the TLR Tollo and Spz-3, which is a neurotrophin-like molecule, but it does not say there is actually an interaction with neurotrophin",""
+"Toll-like receptor signaling pathway","Neurotrophin signaling pathway","Neurotrophin Toll-like Receptor Pathway","24223644","yes","no","activating","TLR4","O00206","UNIPROT","NGFR","P08138","UNIPROT","Homo sapiens","alveolar epithelial cell","BTO:0005760","effects if XQLT","This study showed that the Der p allergen induced NGF and the low-affinity receptor, p75NTR","Der p is an allergen with a structure resembling that of the MD-2 in the TLR4 complex",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","Neurotrophin Toll-like Receptor Pathway","22428454","no","no","","","","","","","","","","","","","The full text was unavailable but the abstract didn't mention any direct interactions between the two pathways",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","Neurotrophin Toll-like Receptor Pathway","11536362","no","no","","","","","","","","","","","","","The text mentions interactions between TLRs and neurotrophin-like compounds, but not between the two directly",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","Neurotrophin Toll-like Receptor Pathway","25863178","no","no","","","","","","","","","","","","","The paper talks about how both are involved in osteonecrosis, but it does not say that the two pathways interact",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","Neurotrophin Toll-like Receptor Pathway","24365204","no","no","","","","","","","","","","","","","The paper talks more about how each pathway individually is associated with the genes involved in schizophrenia, but not how they interact with each other",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","Neurotrophin Toll-like Receptor Pathway","22851955","no","no","","","","","","","","","","","","","The paper doesn't mention any direct interactions between the two pathways",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","Neurotrophin Toll-like Receptor Pathway","22046267","no","no","","","","","","","","","","","","","The paper doesn't mention any direct interactions between the two pathways",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","NGF Toll-like Receptor Pathway","24585880","yes","no","inhibiting","NGF","P01138","UNIPROT","","","","Homo sapiens","monocyte","BTO:0000876","inflammation","Our findings show that, after TLR activation, NGF binding to TrkA activates intracellular pathways that interfere with TLR signaling, potentiating endogenous negative-feedback mechanisms that regulate excessive inflammation","The paper mentions that the neurotrophin, NGF has an effect on and interacts with the TLR pathway",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","NGF Toll-like Receptor Pathway","21381054","no","no","","","","","","","","","","","","","The paper doesn't mention any direct interactions between the two pathways",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","NGF Toll-like Receptor Pathway","23735822","no","no","","","","","","","","","","","","","The paper mentions that the neurotrophin, NGF has an effect on and interacts with the TLR pathway",""
+"Toll-like receptor signaling pathway","Neurotrophin signaling pathway","NGF Toll-like Receptor Pathway","18006062","yes","no","unknown","Tlr4","Q9QUK6","UNIPROT","Ngf,Ngfr","P01139,Q9Z0W1","UNIPROT","Mus musculus","dendritic cell","BTO:0002042","normal","we found that only LPS could up-regulate NGF and p75NTR expression on BMDCs in TLR4 dependent way","The paper says that TLR4 regulates NGF/p75NTR",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","NGF Toll-like Receptor Pathway","22203485","no","no","","","","","","","","","","","","","The text mentions interactions between TLRs and neurotrophin-like compounds, but not between the two directly",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","NGF Toll-like Receptor Pathway","15138588","no","no","","","","","","","","","","","","","The full text was unavailable but the abstract didn't mention any direct interactions between the two pathways",""
+"Jak-STAT signaling pathway","Adipocytokine signaling pathway","Jak-STAT Adipocytokine Pathway","21841463","no","no","","","","","","","","","","","","","The full text was unavailable but the abstract didn't mention any direct interactions between the two pathways",""
+"Jak-STAT signaling pathway","Adipocytokine signaling pathway","Jak-STAT Adipocytokine Pathway","24613686","no","no","","","","","","","","","","","","","The article mentions that STAT3 is part of the JAK/STAT signaling pathway and says that STAT3 played a central role in adipocytokine signaling, which leads to the belief that they crosstalk",""
+"Jak-STAT signaling pathway","Adipocytokine signaling pathway","Jak-STAT Adipocytokine Pathway","21376468","no","no","","","","","","","","","","","","","The article gives evidence of crosstalk from adipocytokine to JAK/STAT, but not from JAK/STAT to adipocytokine",""
+"Jak-STAT signaling pathway","Adipocytokine signaling pathway","Jak-STAT Adipocytokine Pathway","23876795","no","no","","","","","","","","","","","","","The paper does not mention any interaction between the two pathways",""
+"Jak-STAT signaling pathway","Adipocytokine signaling pathway","Jak-STAT Adipocytokine Pathway","24407606","no","no","","","","","","","","","","","","","The paper does not mention any interaction between the two pathways",""
+"Jak-STAT signaling pathway","Adipocytokine signaling pathway","Jak-STAT Adipocytokine Pathway","23383396","no","no","","","","","","","","","","","","","The paper mentions crosstalk from Adipocytokine to Jak-Stat, but not the other way around",""
+"Jak-STAT signaling pathway","Adipocytokine signaling pathway","Jak-STAT Adipocytokine Pathway","21803433","no","no","","","","","","","","","","","","","The abstract mentions regulation of pathways by a different pathway, but not interaction between the two, so the full paper was not read",""
+"Jak-STAT signaling pathway","Adipocytokine signaling pathway","Jak-STAT Adipocytokine Pathway","20564215","no","no","","","","","","","","","","","","","The full text was not read because the abstract mentions that there is interaction from Adipocytokine to Jak-STAT, but does not suggest there is any interaction in the other direction",""
+"Jak-STAT signaling pathway","Adipocytokine signaling pathway","Jak-STAT Adipocytokine Pathway","19139561","no","no","","","","","","","","","","","","","The full text was not read because the abstract mentions that there is interaction from Adipocytokine to Jak-STAT, but does not suggest there is any interaction in the other direction",""
+"Wnt signaling pathway","Adipocytokine signaling pathway","Wnt Adipocytokine Pathway","21915818","no","no","","","","","","","","","","","","","The full text was unavailable, and the abstract mentioned that the two pathways interact, but it did not specify how",""
+"Wnt signaling pathway","Adipocytokine signaling pathway","Wnt Adipocytokine Pathway","24757673","no","no","","","","","","","","","","","","","The full text was not read because the abstract mentioned that both pathways may play a role in regulating SLD genes in chickens, but not that they might interact with each other",""
+"Wnt signaling pathway","Adipocytokine signaling pathway","Wnt Adipocytokine Pathway","22270359","no","no","","","","","","","","","","","","","The paper only mentions crosstalk from Adipocytokine to Wnt, not from Wnt to Adipocytokine",""
+"Wnt signaling pathway","Adipocytokine signaling pathway","Wnt Adipocytokine Pathway","21803433","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned how both pathways were independently regulated by another pathway",""
+"Wnt signaling pathway","Adipocytokine signaling pathway","Wnt Adipocytokine Pathway","18569525","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only talks about how both pathways are affected by a separate receptor from the two pathways",""
+"Wnt signaling pathway","Adipocytokine signaling pathway","Wnt Leptin Crosstalk","21193018","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned crosstalk from leptin to Notch, and Notch and Wnt, but not with leptin and Wnt",""
+"Wnt signaling pathway","Adipocytokine signaling pathway","Wnt Leptin Pathway","25550093","yes","yes","activating","Wnt3a","P27467","UNIPROT","Lep","P41160","UNIPROT","Mus musculus","adipocyte","BTO:0000443","High-fat diet vs low-fat diet","In this study, with commercially available Wnt3a, we demonstrated for the first time that Wnt activation stimulates leptin mRNA expression, hormone secretion and leptin promoter activity","The text mentions that Wnt3a stimulates leptin mRNA expression, but not that the two proteins actually interact, so it would be transcriptional crosstalk",""
+"Wnt signaling pathway","Adipocytokine signaling pathway","Wnt Leptin Pathway","24105484","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned leptin having an effect on the Wnt pathway, and not the other way around",""
+"Wnt signaling pathway","Adipocytokine signaling pathway","Wnt Leptin Pathway","23975746","no","no","","","","","","","","","","","","","The full text was not read because the abstract only described the effect that a different compound had on the two pathways, and did not say that they interacted with each other",""
+"Wnt signaling pathway","Adipocytokine signaling pathway","Wnt Leptin Pathway","24530909","no","no","","","","","","","","","","","","","This article is not very clear as to what the relationships between all the different components of the study are, but there is no mention of any interaction between the Wnt pathway and leptin",""
+"Wnt signaling pathway","Neurotrophin signaling pathway","Wnt Neurotrophin Pathway","23639831","yes","yes","unknown","","","","NTF3","P20783","UNIPROT","Homo sapiens","nervous system","BTO:0001484","sensory nervous system development","several Wnts regulate Neurotrophin-3 expression during sensory nervous system development","Since the article only specifies that Wnts regulate the expression of neurotrophins and does not actually regulate the pathway, it would be transcriptional crosstalk. The article also mentions that Wnt3a regulates BDNF expression in retinal glial cells",""
+"Wnt signaling pathway","Neurotrophin signaling pathway","Wnt Neurotrophin Pathway","22198686","yes","yes","activating","TCF4/LEF1","P15884/Q9UJU2","UNIPROT","BDNF","P23560","UNIPROT","Homo sapiens","glia","BTO:0000524","normal","In this study, we demonstrated that the Wnt signaling pathway directly induces BDNF expression in Muller glia, which are the principle supportive glia in the retina that are the central mediators of growth factor-mediated protection in the retina","A couple points in the paper briefly mention that there may be direct interaction between the two pathways, but it is very ambiguous. The article mainly discusses how the Wnt transcription facts TCF/LEF induce the expression of BDNF",""
+"Wnt signaling pathway","Neurotrophin signaling pathway","Wnt Neurotrophin Pathway","25170755","no","no","","","","","","","","","","","","","The article mainly talks about how both pathways have an effect on hMSCs and doesn't mention that the two pathways crosstalk",""
+"Wnt signaling pathway","Neurotrophin signaling pathway","Wnt Neurotrophin Pathway","24529757","no","no","","","","","","","","","","","","","The full article was not read because the abstract only briefly mentions that the pathways might be related to sALS, but gives no indication that they might interact with each other",""
+"Wnt signaling pathway","Neurotrophin signaling pathway","Wnt Neurotrophin Pathway","22319467","no","no","","","","","","","","","","","","","The article mainly discusses the role of the Wnt pathway in BPD, and its interactions iwth the Akt pathway, but not with the neurotrophin pathway",""
+"Wnt signaling pathway","Neurotrophin signaling pathway","Wnt Neurotrophin Pathway","21383773","no","no","","","","","","","","","","","","","The paper only mentions that Neurotrophin interacts with MAPK, which in turn crosstalks, with Wnt, but no that they crosstalk directly",""
+"Wnt signaling pathway","Neurotrophin signaling pathway","Wnt Neurotrophin Pathway","22697417","no","no","","","","","","","","","","","","","The full text was not read because the abstract only addresses the two pathways in the context of them both showing correlations with neuronal differentiation",""
+"Wnt signaling pathway","VEGF signaling pathway","Wnt VEGF Crosstalk","24644090","no","no","","","","","","","","","","","","","The article described a crosstalk between epithelial and mesenchymal tissues, and not between the two pathways",""
+"Wnt signaling pathway","VEGF signaling pathway","Wnt VEGF Crosstalk","24180397","no","no","","","","","","","","","","","","","The full article was not read because the abstract mentioned that crosstalk was mediated by Akt, and was not direct",""
+"Wnt signaling pathway","VEGF signaling pathway","Wnt VEGF Crosstalk","25355597","no","no","","","","","","","","","","","","","The full article was not read because the abstract discussed the crosstalk between Wnt and TGF, but no mention of any direct interaction between Wnt and VEGF",""
+"Wnt signaling pathway","VEGF signaling pathway","Wnt VEGF Pathway","25657312","no","no","","","","","","","","","","","","","The full text was not read because the abstract made no mention of the VEGF pathway, only the Wnt",""
+"Wnt signaling pathway","VEGF signaling pathway","Wnt VEGF Pathway","25584796","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentioned how ERG has an effect on both pathways, and not how they affect each other",""
+"Wnt signaling pathway","VEGF signaling pathway","Wnt VEGF Pathway","25345941","no","no","","","","","","","","","","","","","The article was written in Chinese so it could not be read, but the abstract didn't mention a direct interaction between the pathways",""
+"Wnt signaling pathway","VEGF signaling pathway","Wnt VEGF Pathway","24064724","yes","yes","activating","CTNNB1","P35222","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","hepatoma cell","BTO:0000608","cancer","Both bindings by curcumin will set the cell in Wnt ‘off-state’ suppressing the nucleus accumution of β -catenin and the expression of Wnt target genes (VEGF, C-myc, cyclinD1, etc)","The article explains that beta-catenin activates the transcription of the genes that code the VEGF protein, and curcumin inhibits the Wnt pathway, which leads to no transcription of the VEGF gene. There is also a detailed and clear diagram that depicts this interaction",""
+"Wnt signaling pathway","VEGF signaling pathway","Wnt VEGF Pathway","25169533","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses the effect of FNC on the expression of genes of both pathways, but does not indicate that they have any interaction",""
+"GnRH signaling pathway","Neurotrophin signaling pathway","GnRH Neurotrophin Pathway","16162927","no","no","","","","","","","","","","","","","The text does not mention that there is any interaction between the pathways, it only discusses the crosstalk from BDNF to other pathways",""
+"GnRH signaling pathway","Neurotrophin signaling pathway","GnRH NGF Pathway","19301301","no","no","","","","","","","","","","","","","The full text was not read because the abstract only very briefly mentioned NGF and that NGF might respond to p53, not GnRH",""
+"GnRH signaling pathway","Neurotrophin signaling pathway","GnRH NGF Pathway","18216230","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not make any mention of GnRH, only of NGF and its interactions with other pathways",""
+"GnRH signaling pathway","Neurotrophin signaling pathway","GnRH BDNF Pathway","15233743","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only describes a relationship where BDNF has an effect on GnRH, and makes no mention that GnRH has any effect on the Neurotrophin pathway",""
+"GnRH signaling pathway","Neurotrophin signaling pathway","GnRH BDNF Pathway","16162927","no","no","","","","","","","","","","","","","The full text was not read because the in the abstract there is only mention of BDNF having an effect on the formation of PrPSc in GnRH-secreting cells, but no mention of any interaction between the two pathways",""
+"GnRH signaling pathway","Neurotrophin signaling pathway","GnRH BDNF Pathway","18824519","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentions that BDNF activates ERK, which increases formation of prions in GnRH cells",""
+"Hippo signaling pathway","HIF-1 signaling pathway","Hippo HIF-1 Crosstalk","26059435","yes","no","inhibiting","TAZ","Q16635","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","breast","BTO:0000149","breast cancer","TAZ interacts with HIF-1α to stimulate transcription of HIF-1 target genes such as PDK1.","The article explains and diagrams that TAZ does in fact bind to HIF-1alpha to cause an increase in transcriptional activity Sarah: Hippo signaling inactivates TAZ so changed to negative",""
+"Hippo signaling pathway","HIF-1 signaling pathway","Hippo HIF-1 Crosstalk","26059435","yes","yes","inhibiting","TAZ","Q16635","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","breast","BTO:0000149","breast cancer","TAZ interacts with HIF-1α to stimulate transcription of HIF-1 target genes such as PDK1.","The article explains that TAZ interacts with HIF-1alpha directly, but it also says that this interaction directly stimulates the expression of HIF-1 target genes, such as PDK1",""
+"Toll-like receptor signaling pathway","ErbB signaling pathway","Toll-like Receptor ErbB Crosstalk","23994140","no","no","","","","","","","","","","","","","The article explains that both pathways are involved in the modulation of immune signaling but only interact through MAPK crosstalk points",""
+"Toll-like receptor signaling pathway","ErbB signaling pathway","Toll-like Receptor ErbB Pathway","24854438","no","no","","","","","","","","","","","","","The text explains that both pathways may be involved in glaucoma development, but gives no evidence that they have any interactions",""
+"Toll-like receptor signaling pathway","ErbB signaling pathway","Toll-like Receptor ErbB Pathway","20122205","no","no","","","","","","","","","","","","","The text is very ambiguous and references many different pathways that interact with each other, but there are no details and nothing definitive. There is a diagram that seems to suggest that the two interact, but again is very ambiguous",""
+"Toll-like receptor signaling pathway","ErbB signaling pathway","Toll-like Receptor EGFR Pathway","23680662","no","no","","","","","","","","","","","","","The relationship described between EGFR and the TLR pathway is not very clear, but it seems like the phosphorylation of EGFR causes some kind of response in cells that are stimulated with TLR5 agonist, which does not suggest crosstalk. There is mention of a flagellin-TLR5-EGFR-IL8 pathway, but there is no context provided for this pathway",""
+"Toll-like receptor signaling pathway","ErbB signaling pathway","Toll-like Receptor EGFR Pathway","23896774","no","no","","","","","","","","","","","","","The relationship between EGFR and the TLR pathway is not very clear. At some points it suggest that the two interact directly, such as ""LPS phosphorylated EGFR,"" and ""TLR4 activation can induce RANTES expression via EGFR transactivation and PI3K/Akt pathway in rat ASMCs."" The paper then later says that LPS binds to TLR4 and activates EGFR signaling through the PI3K/Akt pathway, and that ligand-bound TLR4 is assumed to stimulate EGFR via putative metalloproteinase-induced mechanisms, so the paper seems contradictory. Also, the link to the full paper was not on PubMed, but I found the article by searching for the title in google, and this is the link: http://lib.tmd.ac.jp/jmd/5704/01_Okayasu.pdf",""
+"Toll-like receptor signaling pathway","ErbB signaling pathway","Toll-like Receptor EGFR Pathway","21937604","no","no","","","","","","","","","","","","","The interaction between the two pathways is confusing. The article says that the ""binding of LPS to the TLR4 receptor triggers ectodomain shedding of pro-TGF-α and release of mature TGF-α with subsequent activation of EGFR and downstream MAPKs p38 and ERK1/2."" It also has a diagram that depicts TLR4 causing TGF-alpha to activate the EGFR pathway, but it seems to be indeirect, which leads to the belief that they do not crosstalk",""
+"Toll-like receptor signaling pathway","ErbB signaling pathway","Toll-like Receptor EGFR Pathway","24513215","no","no","","","","","","","","","","","","","The full text was not read because the abstract only talked about the pathways independently activating ERK1/2, and does not mention any interactions with each other",""
+"Toll-like receptor signaling pathway","TGF-beta signaling pathway","Toll-like Receptor TGF-beta Crosstalk","25568862","no","no","","","","","","","","","","","","","The text only describes a relationship where there is crosstalk from TGF-beta to TLR, and any effect that TLR has on TGF-beta is not direct",""
+"Toll-like receptor signaling pathway","TGF-beta signaling pathway","Toll-like Receptor TGF-beta Crosstalk","24801688","no","no","","","","","","","","","","","","","The full text was not read because the abstract only described a kinase mediated interaction between the two pathways, and only mentioned the effect of TGF-beta on TLR",""
+"Toll-like receptor signaling pathway","TGF-beta signaling pathway","Toll-like Receptor TGF-beta Crosstalk","23350913","no","no","","","","","","","","","","","","","The full text was not read because the abstract makes no mention of TGF-beta, only TLR and its role in the inflammatory response",""
+"Toll-like receptor signaling pathway","TGF-beta signaling pathway","Toll-like Receptor TGF-beta Crosstalk","16308570","no","no","","","","","","","","","","","","","It wasn't very clear whether there was crosstalk or not. The article mentioned that LPS may regulate TGF-beta, but the article is very unclear as to how this happens",""
+"Toll-like receptor signaling pathway","TGF-beta signaling pathway","Toll-like Receptor TGF-beta Crosstalk","23770291","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of either of the pathways in the abstract, it only mention crosstalk between NF-kB and SIRT1",""
+"Toll-like receptor signaling pathway","TGF-beta signaling pathway","Toll-like Receptor TGF-beta Crosstalk","20706677","yes","yes","activating","MYD88","Q99836","UNIPROT","BAMBI","Q13145","UNIPROT","Homo sapiens","liver","BTO:0000759","liver fibrosis","Simultaneously, TLR4 signaling downregulates Bambi expression through MyD88 and NF-κB in HSCs","The transcriptional crosstalk was unclear because it says that there is downregulated expression, which most likely means that the crosstalk is transcriptional, but the diagram in the figure suggests that NF-kB may have a direct interaction with Bambi. It is most likely transcriptional because the downregulation of Bambi is compared to the other ""TGF-beta associated genes"" that were unchanged. Since TLR4 reduces Bambi expression, it enhances TGF-beta activity because Bambi restricts TGF-beta activity",""
+"Toll-like receptor signaling pathway","TGF-beta signaling pathway","Toll-like Receptor TGF-beta Crosstalk","17655740","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentions the two pathways separately interacting with other factors",""
+"Toll-like receptor signaling pathway","TGF-beta signaling pathway","Toll-like Receptor TGF-beta Crosstalk","23008717","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned that both pathways were expressed in platelets, and did not give any indication that the two interact",""
+"Toll-like receptor signaling pathway","TGF-beta signaling pathway","Toll-like Receptor TGF-beta Crosstalk","19809894","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentioned that SLRPs are capable of binding to TLRs and TGF-beta, but gave no indication that the two interact",""
+"Toll-like receptor signaling pathway","TGF-beta signaling pathway","Toll-like Receptor TGF-beta Crosstalk","18508652","no","no","","","","","","","","","","","","","Only the abstract was read because it gave no indication that the two pathways interact. It only mentioned that both have some kind of role in dendritic cells",""
+"NF-kappa B signaling pathway","VEGF signaling pathway","NF-kappa B VEGF Crosstalk","23922887","no","no","","","","","","","","","","","","","The full article was not read because the abstract only talks about the two pathways in the context of interacting with other pathways and not each other",""
+"NF-kappa B signaling pathway","VEGF signaling pathway","NF-kappa B VEGF Crosstalk","22513453","yes","yes","activating","NFKB1","P19838","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","salivary gland epithelium","BTO:0004421","SS","VEGF-A can be regulated by activated NF-κB, because its genes have a κB binding site in its promoter region and the secretion of angiogenic factors may be an important mechanism of constitutive NF-κB activation observed in pathological conditions","Not many details are given, but it seems that the article suggests that NF-kB can directly affect the epxression of VEGF-A genes",""
+"NF-kappa B signaling pathway","VEGF signaling pathway","NF-kappa B VEGF Crosstalk","23000338","no","no","","","","","","","","","","","","","The article only mentions that the two pathways are both are activated by NAP, but it does not say that they interact with each other",""
+"NF-kappa B signaling pathway","VEGF signaling pathway","NF-kappa B VEGF Crosstalk","21558328","no","no","","","","","","","","","","","","","The article only talks about the how the two pathways interact with other pathways, not with each other",""
+"NF-kappa B signaling pathway","VEGF signaling pathway","NF-kappa B VEGF Crosstalk","17560613","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned how each pathway interacts with RAGE, and gives no indication that they interact with each other",""
+"NF-kappa B signaling pathway","VEGF signaling pathway","NF-kappa B VEGF Crosstalk","11023512","no","no","","","","","","","","","","","","","The full paper was not read because the abstract made no mention of VEGF",""
+"Hedgehog signaling pathway","Notch signaling pathway","Hedgehog Notch Crosstalk","25965442","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only talked about the two pathways interacting with Dickkopf-1, not each other",""
+"Notch signaling pathway","Hedgehog signaling pathway","Hedgehog Notch Crosstalk","25965442","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only talked about the two pathways interacting with Dickkopf-1, not each other",""
+"Hedgehog signaling pathway","Notch signaling pathway","Hedgehog Notch Crosstalk","24613036","yes","yes","activating","hh","Q02936","UNIPROT","h","P14003","UNIPROT","Drosophila melanogaster","unknown","","normal","Other studies in the fly have indicated links between Hedgehog and Notch signalling previously noted in studies of cultured cerebellar granule cell precursors that Hes1 was upregulated in response to Jagged (Notch ligand) or Shh stimulation, but had not considered the latter was a Notch-independent effect","The paper mentions that the exact molecular mechanisms for the regulation of Hes1 by Shh was still not clear, but that Shh has a clear effect on Hes1, but most likely also involves other transcription factors. This was found in a reference: http://www.nature.com/onc/journal/v27/n10/full/1210767a.html",""
+"Notch signaling pathway","Hedgehog signaling pathway","Hedgehog Notch Crosstalk","24613036","no","no","","","","","","","","","","","","","The paper only mentions an effect on the Notch pathway by the Hh pathway, and does not mention any reciprocal interactions. This was found in a reference: http://www.nature.com/onc/journal/v27/n10/full/1210767a.html",""
+"Hedgehog signaling pathway","Notch signaling pathway","Hedgehog Notch Crosstalk","23032367","yes","yes","unknown","","","","JAG2","Q9Y219","UNIPROT","Homo sapiens","colon","BTO:0000269","colon cancer","Likewise, HH has been reported to control the expression of the Notch ligand Jagged2,","The article only mentions HH regulating expression of Notch ligand, but not any other interactions",""
+"Notch signaling pathway","Hedgehog signaling pathway","Hedgehog Notch Crosstalk","23032367","no","no","","","","","","","","","","","","","The article only mentions HH regulating expression of Notch ligand, but not any other interactions",""
+"Hedgehog signaling pathway","Notch signaling pathway","Hedgehog Notch Cross-talk","23703657","yes","yes","activating","Smo","P56726","UNIPROT","","","","Mus musculus","liver","BTO:0000759","repair","In both cell types, antagonizing Smoothened caused suppression of Notch-2, Jagged-1 and Notch target genes demonstrating that canonical Hh pathway activity promotes the expression of Notch signaling pathway genes","This article was very confusing and was not very clear about what the crosstalk was, it just kept stating that there was crosstalk",""
+"Notch signaling pathway","Hedgehog signaling pathway","Hedgehog Notch Cross-talk","23703657","yes","yes","activating","Aph1b","Q8C7N7","UNIPROT","Gli2","Q0VGT2","UNIPROT","Mus musculus","liver","BTO:0000759","repair","Given that DAPT, a γ-secretase inhibitor that specifically blocks Notch signaling, suppressed expression of Shh ligand, Gli2 (Hh-regulated transcription factor), and Ptc (a direct transcriptional target of Gli) the Notch pathway seems to stimulate Hh pathway activity","",""
+"Hedgehog signaling pathway","Notch signaling pathway","Hedgehog Notch Cross-talk","23667323","no","no","","","","","","","","","","","","","The article claimed in the abstract that crosstalk between HH and Notch would be discussed, but the article only talks about how each is affected by miR-7",""
+"Notch signaling pathway","Hedgehog signaling pathway","Hedgehog Notch Cross-talk","23667323","no","no","","","","","","","","","","","","","The article claimed in the abstract that crosstalk between HH and Notch would be discussed, but the article only talks about how each is affected by miR-7. It suggested that Notch may repress the transcription of boi, but the text seems to only be speculating and not providing evidence",""
+"Hedgehog signaling pathway","Notch signaling pathway","Hedgehog Notch Crosstalk","23973264","no","no","","","","","","","","","","","","","The full article was not read because the abstract doesn't even mention Hh",""
+"Notch signaling pathway","Hedgehog signaling pathway","Hedgehog Notch Crosstalk","23973264","no","no","","","","","","","","","","","","","The full article was not read because the abstract doesn't even mention Hh",""
+"Hedgehog signaling pathway","Notch signaling pathway","Hedgehog Notch Crosstalk","25850553","no","no","","","","","","","","","","","","","The article was mainly about each pathway's crosstalk with Wnt, and some indirect interactions between the pathways, but nothing suggesting they directly effect each other",""
+"Notch signaling pathway","Hedgehog signaling pathway","Hedgehog Notch Crosstalk","25850553","no","no","","","","","","","","","","","","","The article was mainly about each pathway's crosstalk with Wnt, and some indirect interactions between the pathways, but nothing suggesting they directly effect each other",""
+"Hedgehog signaling pathway","Notch signaling pathway","Hedgehog Notch Crosstalk","22876389","no","no","","","","","","","","","","","","","The article talk about each pathway's role in pancreatic cancer but they are discussed separately and there is no indication that they interact in this context",""
+"Notch signaling pathway","Hedgehog signaling pathway","Hedgehog Notch Crosstalk","22876389","no","no","","","","","","","","","","","","","The article talk about each pathway's role in pancreatic cancer but they are discussed separately and there is no indication that they interact in this context",""
+"Hedgehog signaling pathway","Notch signaling pathway","Hedgehog Notch Crosstalk","21193018","yes","no","activating","","","","JAG2","Q9Y219","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Notch ligand, JAG2 is induced by Hedgehog signaling during carcinogenesis","The sentence provided is really the only description of that kind of relationship between Hh and JAG2, but it doesn't seem to suggest that it's transcriptional",""
+"Notch signaling pathway","Hedgehog signaling pathway","Hedgehog Notch Crosstalk","21193018","yes","yes","activating","","","","SHH","Q15465","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Hedgehog signals could induce Hes1 in both C3H/10T1/2 mesodermal and MNS70 neural cells","Since Hes is a target gene of Notch and doesn't seem to play a role in the actual pathway this interaction is most likely transcriptional",""
+"Hedgehog signaling pathway","Notch signaling pathway","Hedgehog Notch Cross-talk","21151206","yes","no","activating","","","","JAG2","Q9Y219","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Hh signaling activation induces Jagged 2, a Notch ligand resulting in upregulation of the Notch pathway","The interaction between Hh and Notch seems to be direct and not transcriptional",""
+"Notch signaling pathway","Hedgehog signaling pathway","Hedgehog Notch Cross-talk","21151206","no","no","","","","","","","","","","","","","There was only an effect on Notch by Hh explained",""
+"Hedgehog signaling pathway","Notch signaling pathway","Hedgehog Notch Cross-talk","21649559","yes","yes","activating","GLI1","P08151","UNIPROT","HEY2","Q9UBP5","UNIPROT","Homo sapiens","embryonic stem cell","BTO:0001086","normal","Interestingly, HEY2 and HES5, NOTCH signaling transcription factors, were identified to be potential direct target genes of GLI, with 3 and 6 putative GLI-binding sites in their 5′ promoter region, respectively","There seemed to be only transcriptional regulation of Notch by Hh",""
+"Notch signaling pathway","Hedgehog signaling pathway","Hedgehog Notch Cross-talk","21649559","no","no","","","","","","","","","","","","","There was only an effect on Notch by Hh explained",""
+"Hedgehog signaling pathway","Wnt signaling pathway","Hedgehog Wnt Crosstalk","25692617","yes","no","inhibiting","GLI3","P10071","UNIPROT","CTNNB1","P35222","UNIPROT","Homo sapiens","colon","BTO:0000269","cancer","Gli3R inhibits b-catenin activity through interact-ing with the C-terminal transactivation domain of b-catenin andthereby antagonizes the active forms of beta-catenin","The text explains a complex relationship between Wnt and Hh, but it mostly provides similarities between pathways, and then briefly explains potential interactions",""
+"Hedgehog signaling pathway","Wnt signaling pathway","Hedgehog Wnt Crosstalk","25692617","yes","yes","activating","GLI1","P08151","UNIPROT","SNAI1","O95863","UNIPROT","Homo sapiens","colon","BTO:0000269","cancer","Gli1 could induce Snail expression, which then interacts with beta-catenin and stimulates its transcriptional activity","The text explains a complex relationship between Wnt and Hh, but it mostly provides similarities between pathways, and then briefly explains potential interactions",""
+"Wnt signaling pathway","Hedgehog signaling pathway","Hedgehog Wnt Crosstalk","25692617","no","no","","","","","","","","","","","","","Although the text is mainly about Wnt and Hh, there does not seem to be any clear evidence that Wnt has a significant effect on Hh",""
+"Hedgehog signaling pathway","Wnt signaling pathway","Hedgehog Wnt Crosstalk","25965442","no","no","","","","","","","","","","","","","The text describes both pathways but only discusses how they interact with other pathways and doesn't mention them interacting with each other",""
+"Wnt signaling pathway","Hedgehog signaling pathway","Hedgehog Wnt Crosstalk","25965442","no","no","","","","","","","","","","","","","The text describes both pathways but only discusses how they interact with other pathways and doesn't mention them interacting with each other",""
+"Hedgehog signaling pathway","Wnt signaling pathway","Hedgehog Wnt Crosstalk","23032367","yes","no","inhibiting","SHH","Q15465","UNIPROT","","","","Homo sapiens","colon","BTO:0000269","epithelial differentiation","HH can antagonize WNT signaling in the colon.","The text mentions that hedgehog has an effect on Wnt, but does not go into very much detail",""
+"Wnt signaling pathway","Hedgehog signaling pathway","Hedgehog Wnt Crosstalk","23032367","yes","no","unknown","","","","GLI3","P10071","UNIPROT","Homo sapiens","colonic cancer cell","BTO:0000586","normal","WNT signals can also control Gli3 from the HH pathway.","The text mentions that Wnt has an effect on Hedgehog, but does not go into very much detail",""
+"Hedgehog signaling pathway","Melanogenesis","Hedgehog Melanogenesis Pathway","10510326","no","no","","","","","","","","","","","","","The text mentions that sonic hedgehog can increase hair growth, but it does not say that it has any role in melanogenesis",""
+"Melanogenesis","Hedgehog signaling pathway","Hedgehog Melanogenesis Pathway","10510326","no","no","","","","","","","","","","","","","The text mentions that sonic hedgehog can increase hair growth, but it does not say that it has any role in melanogenesis",""
+"Hedgehog signaling pathway","Melanogenesis","Hedgehog MSH Pathway","23535605","no","no","","","","","","","","","","","","","The text suggests a relationship between MSH and Shh but it does not provide any evidence or detail",""
+"Melanogenesis","Hedgehog signaling pathway","Hedgehog MSH Pathway","23535605","no","no","","","","","","","","","","","","","The text suggests a relationship between MSH and Shh but it does not provide any evidence or detail",""
+"Hedgehog signaling pathway","Melanogenesis","Hedgehog MSH Pathway","22133830","no","no","","","","","","","","","","","","","The full text was not read because that abstract only mentions that both pathways have a role in osteoblast differentiation, but gives no indication of any potential interactions",""
+"Melanogenesis","Hedgehog signaling pathway","Hedgehog MSH Pathway","22133830","no","no","","","","","","","","","","","","","The full text was not read because that abstract only mentions that both pathways have a role in osteoblast differentiation, but gives no indication of any potential interactions",""
+"Hedgehog signaling pathway","Melanogenesis","Hedgehog MITF Pathway","22496449","yes","yes","inhibiting","GLI2","P10070","UNIPROT","MITF","O75030","UNIPROT","Homo sapiens","melanoma cell","BTO:0000848","proliferation/differentiation","Another mechanism is implicated in the down-regulation of M-MITF expression by the GLI2 transcription factor","The text states that Gli2 has an effect on MITF expression, but then later explains that Gli2 binds directly to the MITF promoter",""
+"Melanogenesis","Hedgehog signaling pathway","Hedgehog MITF Pathway","22496449","no","no","","","","","","","","","","","","","There only seemed to be an effect on MITF by Gli2",""
+"Hedgehog signaling pathway","Melanogenesis","Hedgehog Tyr Pathway","22150777","no","no","","","","","","","","","","","","","The full article was not read because both pathways were mentioned in a different context in the abstract",""
+"Melanogenesis","Hedgehog signaling pathway","Hedgehog Tyr Pathway","22150777","no","no","","","","","","","","","","","","","The full article was not read because both pathways were mentioned in a different context in the abstract",""
+"Hedgehog signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Hedgehog Pathway","19372202","no","no","","","","","","","","","","","","","The paper only mentions P4 regulating Ihh, and does not say that there is any reciprocal interaction. This paper was found by using http://www.nature.com/ng/journal/v38/n10/pdf/ng1874.pdf as a reference and by searching google scholar",""
+"Progesterone-mediated oocyte maturation","Hedgehog signaling pathway","Progesterone Hedgehog Pathway","19372202","yes","yes","activating","P4","hormone","hormone","Ihh","P97812","UNIPROT","Mus musculus","uterine epithelium","BTO:0003082","normal","Previous work has indicated that Ihh is a P4-induced gene in uterine epithelium","The text says that the Ihh gene is stimulated by progesterone, but it does not give much more detail than that. This paper was found by using http://www.nature.com/ng/journal/v38/n10/pdf/ng1874.pdf as a reference and by searching google scholar",""
+"Hedgehog signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Hedgehog Crosstalk","25252859","no","no","","","","","","","","","","","","","The full text was not read because there was no indication in the abstract that there was any interaction between the pathways, it only mentioned crosstalk between different pathways",""
+"Progesterone-mediated oocyte maturation","Hedgehog signaling pathway","Progesterone Hedgehog Crosstalk","25252859","no","no","","","","","","","","","","","","","The full text was not read because there was no indication in the abstract that there was any interaction between the pathways, it only mentioned crosstalk between different pathways",""
+"Hedgehog signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Hedgehog Pathway","24476135","no","no","","","","","","","","","","","","","The full paper was not read because the abstract does not mention any potential interactions between the two pathways",""
+"Progesterone-mediated oocyte maturation","Hedgehog signaling pathway","Progesterone Hedgehog Pathway","24476135","no","no","","","","","","","","","","","","","The full paper was not read because the abstract does not mention any potential interactions between the two pathways",""
+"Hedgehog signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Hedgehog Pathway","23796460","no","no","","","","","","","","","","","","","The full paper was not read because the abstract does not mention any potential interactions between the two pathways",""
+"Progesterone-mediated oocyte maturation","Hedgehog signaling pathway","Progesterone Hedgehog Pathway","23796460","no","no","","","","","","","","","","","","","The full paper was not read because the abstract does not mention any potential interactions between the two pathways",""
+"Hedgehog signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Hedgehog Pathway","25582983","no","no","","","","","","","","","","","","","The full text was not read because the abstract only talks about the relationship Hh has on cholesterol, and mentions that it converts cholesterol to P4, but does not mention any direct interactions",""
+"Progesterone-mediated oocyte maturation","Hedgehog signaling pathway","Progesterone Hedgehog Pathway","25582983","no","no","","","","","","","","","","","","","The full text was not read because the abstract only talks about the relationship Hh has on cholesterol, and mentions that it converts cholesterol to P4, but does not mention any direct interactions",""
+"Hedgehog signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Hedgehog Pathway","23704310","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentions interactions between the pathways and other things, not with each other",""
+"Progesterone-mediated oocyte maturation","Hedgehog signaling pathway","Progesterone Hedgehog Pathway","23704310","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentions interactions between the pathways and other things, not with each other",""
+"Hedgehog signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Hedgehog Pathway","19433502","no","no","","","","","","","","","","","","","The full text was not read because the abstract made no mention of progesterone or any interaction it might have with Hedgehog",""
+"Progesterone-mediated oocyte maturation","Hedgehog signaling pathway","Progesterone Hedgehog Pathway","19433502","no","no","","","","","","","","","","","","","The full text was not read because the abstract made no mention of progesterone or any interaction it might have with Hedgehog",""
+"Hedgehog signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Hedgehog Pathway","22798293","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentions how both are affected by Dicer and miRNA",""
+"Progesterone-mediated oocyte maturation","Hedgehog signaling pathway","Progesterone Hedgehog Pathway","22798293","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentions how both are affected by Dicer and miRNA",""
+"Hedgehog signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Hedgehog Pathway","12351698","no","no","","","","","","","","","","","","","The text is very confusing about the relationship. The abstract mentions that the expression of Ihh is stimulated by P4, but does not expand or explain that later in the paper",""
+"Progesterone-mediated oocyte maturation","Hedgehog signaling pathway","Progesterone Hedgehog Pathway","12351698","no","no","","","","","","","","","","","","","The text is very confusing about the relationship. The abstract mentions that the expression of Ihh is stimulated by P4, but does not expand or explain that later in the paper",""
+"Hedgehog signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Hedgehog Pathway","11977981","no","no","","","","","","","","","","","","","The text only mentions an effect of P4 on Ihh, but not the other way around",""
+"Progesterone-mediated oocyte maturation","Hedgehog signaling pathway","Progesterone Hedgehog Pathway","11977981","yes","yes","activating","P4","hormone","hormone","Ihh","P97812","UNIPROT","Mus musculus","uterus","BTO:0001424","normal","Here, we provide evidence that Ihh expression in the glands of the uterus can be  upregulated by P4 in the  absence of the nuclear receptor","The text states that P4 has a an effect on the expression of Ihh",""
+"Hedgehog signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Hedgehog Pathway","16951680","no","no","","","","","","","","","","","","","The text mentions a potential interaction between the two, but is not conclusive enough to say they crosstalk. A reference was gained from this paper, and the reference is recorded above",""
+"Progesterone-mediated oocyte maturation","Hedgehog signaling pathway","Progesterone Hedgehog Pathway","16951680","no","no","","","","","","","","","","","","","The text mentions a potential interaction between the two, but is not conclusive enough to say they crosstalk. A reference was gained from this paper, and the reference is recorded above",""
+"Hedgehog signaling pathway","Thyroid hormone synthesis","Hedgehog Thyroid hormone synthesis Crosstalk","24693967","no","no","","","","","","","","","","","","","The article only mentioned that Hedgehog has an interaction with thyroid hormone itself, and not an interaction with the synthesis pathway",""
+"Thyroid hormone synthesis","Hedgehog signaling pathway","Hedgehog Thyroid hormone synthesis Crosstalk","24693967","no","no","","","","","","","","","","","","","The article only mentioned that Hedgehog has an interaction with thyroid hormone itself, and not an interaction with the synthesis pathway",""
+"Hedgehog signaling pathway","Thyroid hormone synthesis","Hedgehog Thyroid hormone synthesis Pathway","22967761","no","no","","","","","","","","","","","","","The full article was not read because the abstract only briefly mentions hedgehog and in the context of regulating expression of D2, which doesn't appear to be in the thyroid synthesis pathway",""
+"Thyroid hormone synthesis","Hedgehog signaling pathway","Hedgehog Thyroid hormone synthesis Pathway","22967761","no","no","","","","","","","","","","","","","The full article was not read because the abstract only briefly mentions hedgehog and in the context of regulating expression of D2, which doesn't appear to be in the thyroid synthesis pathway",""
+"Hedgehog signaling pathway","Thyroid hormone synthesis","Hedgehog Thyroid hormone synthesis Pathway","21363934","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentions that thyroid hormone has an impact on Shh expression, and that is the only interaction focused on",""
+"Thyroid hormone synthesis","Hedgehog signaling pathway","Hedgehog Thyroid hormone synthesis Pathway","21363934","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentions that thyroid hormone has an impact on Shh expression, and that is the only interaction focused on",""
+"Hedgehog signaling pathway","Thyroid hormone synthesis","Hedgehog Thyroid hormone synthesis Pathway","25121996","no","no","","","","","","","","","","","","","The text suggests that Hedgehog plays some role in TH homeostasis, but mostly in the context of liver injury, and is not clear on any details",""
+"Thyroid hormone synthesis","Hedgehog signaling pathway","Hedgehog Thyroid hormone synthesis Pathway","25121996","no","no","","","","","","","","","","","","","The text suggests that Hedgehog plays some role in TH homeostasis, but mostly in the context of liver injury, and is not clear on any details",""
+"Hedgehog signaling pathway","Thyroid hormone synthesis","Hedgehog TSH Pathway","23750337","no","no","","","","","","","","","","","","","The text says that some hedgehog proteins may regulate D2 and D3 activity which affects T4/T3 but it does not give any specific details",""
+"Thyroid hormone synthesis","Hedgehog signaling pathway","Hedgehog TSH Pathway","23750337","no","no","","","","","","","","","","","","","The text says that some hedgehog proteins may regulate D2 and D3 activity which affects T4/T3 but it does not give any specific details",""
+"Hedgehog signaling pathway","Thyroid hormone synthesis","Hedgehog TSH Pathway","19926888","no","no","","","","","","","","","","","","","The full text was not read because the abstract made no mention of thyroid hormone or any interaction it might have with hedgehog",""
+"Thyroid hormone synthesis","Hedgehog signaling pathway","Hedgehog TSH Pathway","19926888","no","no","","","","","","","","","","","","","The full text was not read because the abstract made no mention of thyroid hormone or any interaction it might have with hedgehog",""
+"Hedgehog signaling pathway","Thyroid hormone synthesis","Hedgehog TSH Pathway","11784100","no","no","","","","","","","","","","","","","The full article wasn't read because the abstract didn't mention thyroid hormone at all or any interaction between thyroid hormone synthesis and hedgehog",""
+"Thyroid hormone synthesis","Hedgehog signaling pathway","Hedgehog TSH Pathway","11784100","no","no","","","","","","","","","","","","","The full article wasn't read because the abstract didn't mention thyroid hormone at all or any interaction between thyroid hormone synthesis and hedgehog",""
+"Hedgehog signaling pathway","mTOR signaling pathway","Hedgehog mTOR Crosstalk","25742482","unclear","unknown","activating","","","","","","","Homo sapiens","bile duct","BTO:0000122","cancer","Although combined therapy was superior, inhibition of p70S6K also occurred with vismodegib and p-Gli1 with rapamycin, which supports the idea of bi-directional cross talk between the pathways","Other than the sentences noted, there is not any other clear evidence of any crosstalk",""
+"mTOR signaling pathway","Hedgehog signaling pathway","Hedgehog mTOR Crosstalk","25742482","yes","yes","activating","","","","GLI1","P08151","UNIPROT","Homo sapiens","bile duct","BTO:0000122","cancer","activated mTOR pathway promotes Gli1 transcriptional activity and oncogenic function","Other than the sentences noted, there is not any other clear evidence of any crosstalk",""
+"Hedgehog signaling pathway","mTOR signaling pathway","Hedgehog mTOR Crosstalk","24613036","unclear","no","unknown","","","","","","","Homo sapiens","many","","various cancers","Overexpression of Hh signaling proteins and crosstalk between the Hh and PI3K/AKT/mTOR pathways have been observed in esophageal cancer models","The specifics of the crosstalk are not very clear, but it is clear that the two crosstalk",""
+"mTOR signaling pathway","Hedgehog signaling pathway","Hedgehog mTOR Crosstalk","24613036","yes","no","unknown","","","","GLI3","P10071","UNIPROT","Homo sapiens","many","","various cancers","The PI3K/AKT/mTOR pathway, which plays a role in growth, metabolism, motility, proliferation, differentiation, survival, and angiogenesis has been shown to regulate GLI activity in both normal and cancerous cells","The specifics of the crosstalk are not very clear, but it is clear that the two crosstalk",""
+"Hedgehog signaling pathway","Adipocytokine signaling pathway","Hedgehog Leptin Crosstalk","21193018","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses the interactions each pathway has with Notch, and does not mention any interaction that they might have with each other",""
+"Adipocytokine signaling pathway","Hedgehog signaling pathway","Hedgehog Leptin Crosstalk","21193018","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses the interactions each pathway has with Notch, and does not mention any interaction that they might have with each other",""
+"Hedgehog signaling pathway","Adipocytokine signaling pathway","Hedgehog Leptin Crosstalk","25804855","no","no","","","","","","","","","","","","","The full article was not read because hedgehog and leptin are only mentioned briefly and in separate contexts",""
+"Adipocytokine signaling pathway","Hedgehog signaling pathway","Hedgehog Leptin Crosstalk","25804855","no","no","","","","","","","","","","","","","The full article was not read because hedgehog and leptin are only mentioned briefly and in separate contexts",""
+"Hedgehog signaling pathway","Adipocytokine signaling pathway","Hedgehog Leptin Pathway","20843817","no","no","","","","","","","","","","","","","The article mentions that leptin stimulates production of Shh ligand, but is ambiguous about the details. There is mention of activation of PI3K/Akt signaling to mediate, but that is also ambiguous so it is hard to tell what the relationship between them is",""
+"Adipocytokine signaling pathway","Hedgehog signaling pathway","Hedgehog Leptin Pathway","20843817","no","no","","","","","","","","","","","","","The article mentions that leptin stimulates production of Shh ligand, but is ambiguous about the details. There is mention of activation of PI3K/Akt signaling to mediate, but that is also ambiguous so it is hard to tell what the relationship between them is",""
+"Hedgehog signaling pathway","Adipocytokine signaling pathway","Hedgehog Leptin Pathway","17952094","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only briefly mentioned leptin, and that the mice being studied were leptin-deficient but there wasn't any indication that there was an interaction between the pathways",""
+"Adipocytokine signaling pathway","Hedgehog signaling pathway","Hedgehog Leptin Pathway","17952094","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only briefly mentioned leptin, and that the mice being studied were leptin-deficient but there wasn't any indication that there was an interaction between the pathways",""
+"Hedgehog signaling pathway","Adipocytokine signaling pathway","Gli Leptin Pathway","25093391","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Adipocytokine signaling pathway","Hedgehog signaling pathway","Gli Leptin Pathway","25093391","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Hedgehog signaling pathway","ErbB signaling pathway","Hedgehog ErbB Crosstalk","25355554","no","no","","","","","","","","","","","","","The paper only explains that EGFR inhibits Shh, but does not give any evidence that there is any bidirectional crosstalk",""
+"ErbB signaling pathway","Hedgehog signaling pathway","Hedgehog ErbB Crosstalk","25355554","yes","yes","inhibiting","Egfr","Q01279","UNIPROT","Shh","Q62226","UNIPROT","Mus musculus","intestinal epithelium","BTO:0000781","Beta1 deficient","EGFR/MAPK signaling inhibits Shh expression at the level of transcription according to our studies","The paper clearly states that EGFR inhibits that transcription of Shh genes",""
+"Hedgehog signaling pathway","ErbB signaling pathway","Hedgehog ErbB Pathway","25739959","no","no","","","","","","","","","","","","","The full article was not read because the abstract only talks about the two pathways and how they are affected by p63",""
+"ErbB signaling pathway","Hedgehog signaling pathway","Hedgehog ErbB Pathway","25739959","no","no","","","","","","","","","","","","","The full article was not read because the abstract only talks about the two pathways and how they are affected by p64",""
+"Hedgehog signaling pathway","ErbB signaling pathway","Hedgehog ErbB Pathway","25599599","no","no","","","","","","","","","","","","","The article explained that ErbB signaling crosstalks with GPCR, but discusses hedgehog signaling in the same paragraph but in a very confusing way. It does say that there may be evidence of crosstalk between ErbB and Hh, but it uses the evidence that SMO functions like a GPCR and is structurally similar, so the crosstalk was unclear",""
+"ErbB signaling pathway","Hedgehog signaling pathway","Hedgehog ErbB Pathway","25599599","no","no","","","","","","","","","","","","","The article explained that ErbB signaling crosstalks with GPCR, but discusses hedgehog signaling in the same paragraph but in a very confusing way. It does say that there may be evidence of crosstalk between ErbB and Hh, but it uses the evidence that SMO functions like a GPCR and is structurally similar, so the crosstalk was unclear",""
+"Hedgehog signaling pathway","ErbB signaling pathway","Hedgehog ErbB Pathway","24946763","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentions how a certain condition affects each pathway, but gives no indication that they might interact",""
+"ErbB signaling pathway","Hedgehog signaling pathway","Hedgehog ErbB Pathway","24946763","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentions how a certain condition affects each pathway, but gives no indication that they might interact",""
+"Hedgehog signaling pathway","ErbB signaling pathway","Hedgehog ErbB Pathway","18348720","yes","yes","inhibiting","","","","EGFR","P00533","UNIPROT","Homo sapiens","prostate gland","BTO:0001129","prostate cancer","cyclopamine treatment of PC3 cells causing downregulation of EGFR expression","Cyclopamine is a hedgehog inhibitor, so if the introduction of this causes downregulation of EGFR expression, then there is most likely some interaction between hedgehog and ErbB to do this, although not much detail is given",""
+"ErbB signaling pathway","Hedgehog signaling pathway","Hedgehog ErbB Pathway","18348720","yes","no","activating","EGF","P01133","UNIPROT","","","","Homo sapiens","prostate gland","BTO:0001129","prostate cancer","The synergy between cyclopamine and gefitinib or lapatinib may occur because of interactions between the Hedgehog and ErbB pathways, consistent with EGF signalling selectively enhancing Hedgehog activity","Not many details are provided, but the paper does say that the two pathways interact",""
+"Hedgehog signaling pathway","ErbB signaling pathway","Hedgehog ErbB Pathway","22235097","no","no","","","","","","","","","","","","","The full article was not read because the abstract made no mention of the pathways potentially interacting with each other",""
+"ErbB signaling pathway","Hedgehog signaling pathway","Hedgehog ErbB Pathway","22235097","no","no","","","","","","","","","","","","","The full article was not read because the abstract made no mention of the pathways potentially interacting with each other",""
+"Hedgehog signaling pathway","ErbB signaling pathway","Hedgehog ErbB Pathway","14520413","no","no","","","","","","","","","","","","","The full text was not read because the abstract doesn't mention that there is any potential interactions between the two pathways",""
+"ErbB signaling pathway","Hedgehog signaling pathway","Hedgehog ErbB Pathway","14520413","no","no","","","","","","","","","","","","","The full text was not read because the abstract doesn't mention that there is any potential interactions between the two pathways",""
+"Hedgehog signaling pathway","ErbB signaling pathway","Hedgehog ErbB Pathway","20524931","no","no","","","","","","","","","","","","","The full paper was not read because in the abstract it discusses how both pathways might be affected by a new drug to treat ovarian cancer, but they are discussed separately and don't give any inclination that the two may interact",""
+"ErbB signaling pathway","Hedgehog signaling pathway","Hedgehog ErbB Pathway","20524931","no","no","","","","","","","","","","","","","The full paper was not read because in the abstract it discusses how both pathways might be affected by a new drug to treat ovarian cancer, but they are discussed separately and don't give any inclination that the two may interact",""
+"Hedgehog signaling pathway","ErbB signaling pathway","Hedgehog EGFR Crosstalk","24613036","yes","no","activating","","","","","","","Homo sapiens","pancreas","BTO:0000988","cancer","In pancreatic cancer cell lines, Hh activation induced activation of the EGFR/AKT pathway and vice versa","The paper clearly states the effect that Hh has on EGFR, but doesn't provide many details",""
+"ErbB signaling pathway","Hedgehog signaling pathway","Hedgehog EGFR Crosstalk","24613036","yes","yes","activating","JUN","P05412","UNIPROT","GLI1","P08151","UNIPROT","Homo sapiens","basal cell carcinoma cell","BTO:0001298","transformation","Consistent with this hypothesis, EGFR pathway activation stimulated JUN/AP-1, which cooperated with GLI proteins to activate downstream GLI/EGF target genes involved in the transformation of BCC cell lines","The only interactions found from EGFR to Hh was transcriptional, but there were multiple transcriptional crosstalk events described",""
+"ErbB signaling pathway","Hedgehog signaling pathway","Hedgehog EGFR Crosstalk","24613036","yes","yes","inhibiting","","","","PTCH1","Q13635","UNIPROT","Homo sapiens","medulloblastoma cell","BTO:0001757","normal","Unlike the previous examples, where EGFR signaling led to activation of GLI and its target genes, EGFR signaling in a human MB cell line led to downregulation of canonical Hh target genes including the negative regulators PTCH and hedgehog interacting protein—this effect was independent of MEK and PI3K signaling","The only interactions found from EGFR to Hh was transcriptional, but there were multiple transcriptional crosstalk events described",""
+"Hedgehog signaling pathway","Estrogen signaling pathway","Hedgehog Estrogen Crosstalk","24393846","no","no","","","","","","","","","","","","","The full text was not read because the abstract does not even mention anything about estrogen",""
+"Estrogen signaling pathway","Hedgehog signaling pathway","Hedgehog Estrogen Crosstalk","24393846","no","no","","","","","","","","","","","","","The full text was not read because the abstract does not even mention anything about estrogen",""
+"Hedgehog signaling pathway","Estrogen signaling pathway","Hedgehog Estrogen Crosstalk","24104551","no","no","","","","","","","","","","","","","The text mentioned hedgehog but the way it was discussed was confusing. There was no mention of any crosstalk between the two, but it seems that estrogen may have an effect on Ihh but through other mechanisms",""
+"Estrogen signaling pathway","Hedgehog signaling pathway","Hedgehog Estrogen Crosstalk","24104551","no","no","","","","","","","","","","","","","The text mentioned hedgehog but the way it was discussed was confusing. There was no mention of any crosstalk between the two, but it seems that estrogen may have an effect on Ihh but through other mechanisms",""
+"Hedgehog signaling pathway","Estrogen signaling pathway","Hedgehog Estrogen Crosstalk","25252859","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentions that the type of cancer studied typically lacks the estrogen receptor, and then goes on to talk about how GLI1 crosstalks with NFkB, but does not give any evidence that the Hh and estrogen crosstalk",""
+"Estrogen signaling pathway","Hedgehog signaling pathway","Hedgehog Estrogen Crosstalk","25252859","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentions that the type of cancer studied typically lacks the estrogen receptor, and then goes on to talk about how GLI1 crosstalks with NFkB, but does not give any evidence that the Hh and estrogen crosstalk",""
+"Hedgehog signaling pathway","Estrogen signaling pathway","Hedgehog Estrogen Crosstalk","21193018","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only talks about how each pathway interacts with Notch, and does not mention how each might interact with each other",""
+"Estrogen signaling pathway","Hedgehog signaling pathway","Hedgehog Estrogen Crosstalk","21193018","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only talks about how each pathway interacts with Notch, and does not mention how each might interact with each other",""
+"Hedgehog signaling pathway","Estrogen signaling pathway","Hedgehog Estrogen Crosstalk","25815127","no","no","","","","","","","","","","","","","The paper discusses neurons derived from embryonic stem cells, and discusses how estrogen receptor and the hedgehog pathway would be involved in those neurons, but they are discussed separately and there is no indication that the two interact",""
+"Estrogen signaling pathway","Hedgehog signaling pathway","Hedgehog Estrogen Crosstalk","25815127","no","no","","","","","","","","","","","","","The paper discusses neurons derived from embryonic stem cells, and discusses how estrogen receptor and the hedgehog pathway would be involved in those neurons, but they are discussed separately and there is no indication that the two interact",""
+"Hedgehog signaling pathway","Estrogen signaling pathway","Hedgehog Estrogen Crosstalk","16866313","no","no","","","","","","","","","","","","","The full article was not read because the abstract suggests that both pathways are involved in the female reproductive system, but their roles are mentioned separately and there is no evidence that they interact",""
+"Estrogen signaling pathway","Hedgehog signaling pathway","Hedgehog Estrogen Crosstalk","16866313","no","no","","","","","","","","","","","","","The full article was not read because the abstract suggests that both pathways are involved in the female reproductive system, but their roles are mentioned separately and there is no evidence that they interact",""
+"Hedgehog signaling pathway","Estrogen signaling pathway","Hedgehog Estrogen Pathway","24769368","no","no","","","","","","","","","","","","","The article only seemed to mention that ERalpha had an effect on Shh, although the article also says that ""these data support the existence of a pathway stimulated by the Hh-ligands in mammary epithelial cells that operates through both c-src and ERα resulting in the activation of Erk1/2"" which may mean Hh affects ERalpha or ERK1/2, but it is not very conclusive or descriptive",""
+"Estrogen signaling pathway","Hedgehog signaling pathway","Hedgehog Estrogen Pathway","24769368","yes","no","activating","Esr1","P19785","UNIPROT","Shh","Q62226","UNIPROT","Mus musculus","mesenchymal cell","BTO:0002625","mesenchymal dysplasia","Our data also showed that stimulation by N-Shh of primary mammary epithelial cells activated Erk1/2 in both an ERα and c-src-dependent manner","This article was very confusing and didn't describe the relationship between Shh and ERalpha very clearly, although it does seem that ERalpha has some kind of facilitating role for N-Shh to stimulate ERK1/2",""
+"Hedgehog signaling pathway","Estrogen signaling pathway","Hedgehog Estrogen Pathway","22281977","yes","yes","activating","estrogen","hormone","hormone","SHH","Q15465","UNIPROT","Homo sapiens","stomach","BTO:0001307","cancer","Estrogen can induce expression of Shh in ER positive cell lines","The text explains that there is still a lot to learn about this crosstalk, and only explains a very basic crosstalk",""
+"Estrogen signaling pathway","Hedgehog signaling pathway","Hedgehog Estrogen Pathway","22281977","yes","no","unknown","","","","","","","Homo sapiens","stomach","BTO:0001307","cancer","During development and oncogenesis, Hh and ERalpha pathways can directly regulate key components of each other","The text explains that there is still a lot to learn about this crosstalk, and only explains a very basic crosstalk",""
+"Hedgehog signaling pathway","Estrogen signaling pathway","Hedgehog Estrogen Pathway","24889938","no","no","","","","","","","","","","","","","There was only mention of crosstalk from estrogen to Hh, not from Hh to estrogen",""
+"Estrogen signaling pathway","Hedgehog signaling pathway","Hedgehog Estrogen Pathway","24889938","yes","yes","activating","estrogen","hormone","hormone","GLI1","P08151","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","breast cancer","We found that estrogen induced transcriptional activation of Gli1 through enriching ER occupancy at the Gli1 gene promoter and gene body","There were not any protein-protein interactions found, only transcriptional",""
+"Estrogen signaling pathway","Hedgehog signaling pathway","Hedgehog Estrogen Pathway","24889938","yes","yes","activating","estrogen","hormone","hormone","GLI1","P08151","UNIPROT","Homo sapiens","cancer stem cell","BTO:0004254","breast cancer","We found that estrogen induced transcriptional activation of Gli1 through enriching ER occupancy at the Gli1 gene promoter and gene body","There were not any protein-protein interactions found, only transcriptional",""
+"Hedgehog signaling pathway","Estrogen signaling pathway","Hedgehog Estrogen Pathway","25889650","no","no","","","","","","","","","","","","","The text mostly talked about Hedgehog acyltransferase, which modifies Shh to be able to signal the Hh pathway. The text also says that there is evidence against a direct interaction between Hhat and ER",""
+"Estrogen signaling pathway","Hedgehog signaling pathway","Hedgehog Estrogen Pathway","25889650","no","no","","","","","","","","","","","","","The text mostly talked about Hedgehog acyltransferase, which modifies Shh to be able to signal the Hh pathway. The text also says that there is evidence against a direct interaction between Hhat and ER",""
+"Hedgehog signaling pathway","Estrogen signaling pathway","Hedgehog Estrogen Pathway","20087349","no","no","","","","","","","","","","","","","The text states explicitely that, at least in this context, Hedgehog does not affect the ERalpha pathway",""
+"Estrogen signaling pathway","Hedgehog signaling pathway","Hedgehog Estrogen Pathway","20087349","yes","no","activating","ESR1","P03372","UNIPROT","SHH","Q15465","UNIPROT","Homo sapiens","stomach","BTO:0001307","gastric cancer","One finding is that the ERα pathway affects the Hh pathway, because E2 induces both ERα pathway activation and Shh induction, followed by Hh pathway activation, and all of these phenomena were almost completely suppressed by blockade of the ERα pathway","It is stated in the text that molecular mechanisms of the induction of Shh are not clear, but the text does not give any indication that the crosstalk is transcriptional",""
+"Hedgehog signaling pathway","Estrogen signaling pathway","Hedgehog Estrogen Pathway","25503972","yes","no","activating","SHH","Q15465","UNIPROT","ESR1","P03372","UNIPROT","Homo sapiens","breast","BTO:0000149","breast cancer","Silencing of PTCH1 leads to a reduced number of receptor molecules on the membrane, allowing increased binding of endogenous Shh to the ERα, which leads to upregulation of ERα expression since ERα autoregulates its own expression","The text states that there is a direct interaction between Shh and ERalpha that has an effect on the ERalpha pathway",""
+"Estrogen signaling pathway","Hedgehog signaling pathway","Hedgehog Estrogen Pathway","25503972","yes","no","activating","ESR1","P03372","UNIPROT","SHH","Q15465","UNIPROT","Homo sapiens","breast","BTO:0000149","breast cancer","It was shown that upregulation of ERα by E2 also upregulated Shh which canonically activated Hh-Gli signaling and Gli1 expression in human breast cancer cells","The relationship is not described in detail and is not very clear, but there is no indication that the regulation is transcriptional, so it is assumed to be direct",""
+"Hedgehog signaling pathway","GnRH signaling pathway","Hedgehog GnRH Pathway","24574096","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only talks about evidence of Hh signaling in mammalian male germline stem cells, and it also mentions that GnRH causes the differentiation into sperm cells. It does not mention that the two interact at all",""
+"GnRH signaling pathway","Hedgehog signaling pathway","Hedgehog GnRH Pathway","24574096","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only talks about evidence of Hh signaling in mammalian male germline stem cells, and it also mentions that GnRH causes the differentiation into sperm cells. It does not mention that the two interact at all",""
+"Hedgehog signaling pathway","GnRH signaling pathway","Hedgehog GnRH Pathway","24879419","no","no","","","","","","","","","","","","","The full article was not read because there is no suggestion of a direct relationship, only that Hh participates in the development of neurons that express gnrh3",""
+"GnRH signaling pathway","Hedgehog signaling pathway","Hedgehog GnRH Pathway","24879419","no","no","","","","","","","","","","","","","The full article was not read because there is no suggestion of a direct relationship, only that Hh participates in the development of neurons that express gnrh4",""
+"Hedgehog signaling pathway","GnRH signaling pathway","Hedgehog GnRH Pathway","18825689","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not even mention GnRH",""
+"GnRH signaling pathway","Hedgehog signaling pathway","Hedgehog GnRH Pathway","18825689","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not even mention GnRH",""
+"Hedgehog signaling pathway","GnRH signaling pathway","Hedgehog MT1 Pathway","20856928","no","no","","","","","","","","","","","","","The full text was not read because MT-1 was hardly mentioned and was mentioned in a different context than Hh in the abstract",""
+"GnRH signaling pathway","Hedgehog signaling pathway","Hedgehog MT1 Pathway","20856928","no","no","","","","","","","","","","","","","The full text was not read because MT-1 was hardly mentioned and was mentioned in a different context than Hh in the abstract",""
+"Hedgehog signaling pathway","GnRH signaling pathway","Hedgehog MT1 Pathway","19028702","no","no","","","","","","","","","","","","","The full text was not read because MT-1 was hardly mentioned and was mentioned in a different context than Hh in the abstract",""
+"GnRH signaling pathway","Hedgehog signaling pathway","Hedgehog MT1 Pathway","19028702","no","no","","","","","","","","","","","","","The full text was not read because MT-1 was hardly mentioned and was mentioned in a different context than Hh in the abstract",""
+"Hedgehog signaling pathway","HIF-1 signaling pathway","Hedgehog HIF-1 Pathway","25502463","no","no","","","","","","","","","","","","","There was no mention of any effect that hedgehog has on HIF-1",""
+"HIF-1 signaling pathway","Hedgehog signaling pathway","Hedgehog HIF-1 Pathway","25502463","yes","yes","activating","Hif1a","O35800","UNIPROT","Shh","Q63673","UNIPROT","Rattus norvegicus","cerebral cortical neuron","BTO:0004102","Alzheimer's","Chromatin immunoprecipitation (ChIP) assay demonstrated that Aβ25-35 enhanced binding of hypoxia-inducible factor-1 (HIF-1) to the promoter of the Shh gene in primary cortical cultures","The only interactions mentioned were transcriptional, and the explanations were confusing when it came down to details",""
+"Hedgehog signaling pathway","HIF-1 signaling pathway","Hedgehog HIF-1 Pathway","24067457","no","no","","","","","","","","","","","","","The full article was not read because the abstract only briefly mentions hedgehog and only says that ShhCre transgenic mice were mated with HIF-1alpha fl/fl mice to creat HIF-1alpha KO mice",""
+"HIF-1 signaling pathway","Hedgehog signaling pathway","Hedgehog HIF-1 Pathway","24067457","no","no","","","","","","","","","","","","","The full article was not read because the abstract only briefly mentions hedgehog and only says that ShhCre transgenic mice were mated with HIF-1alpha fl/fl mice to creat HIF-1alpha KO mice",""
+"Hedgehog signaling pathway","HIF-1 signaling pathway","Hedgehog HIF-1 Pathway","21063852","no","no","","","","","","","","","","","","","This article was very confusing. It seems that HIF-1 and Shh may have some interaction, but it is very ambiguous. It seems that cyclopamine inhibits both Shh and expression of HIF-1, so there is a potential for maybe transcriptional crosstalk, but the relationship is unclear",""
+"HIF-1 signaling pathway","Hedgehog signaling pathway","Hedgehog HIF-1 Pathway","21063852","no","no","","","","","","","","","","","","","This article was very confusing. It seems that HIF-1 and Shh may have some interaction, but it is very ambiguous. It seems that cyclopamine inhibits both Shh and expression of HIF-1, so there is a potential for maybe transcriptional crosstalk, but the relationship is unclear",""
+"Hedgehog signaling pathway","HIF-1 signaling pathway","Hedgehog HIF-1 Pathway","23786654","no","no","","","","","","","","","","","","","The article only mentions an effect on Hh by HIF-1, not the other way around",""
+"HIF-1 signaling pathway","Hedgehog signaling pathway","Hedgehog HIF-1 Pathway","23786654","yes","yes","activating","HIF1A","Q16665","UNIPROT","SMO","Q99835","UNIPROT","Homo sapiens","pancreas","BTO:0000988","cancer","These results indicate that hypoxia activates Hh signaling via up-regulation of SMO expression","The article didn't provide much detail but it does say that hypoxia activates through regulation of expression",""
+"Hedgehog signaling pathway","HIF-1 signaling pathway","Hedgehog HIF-1 Pathway","22822532","no","no","","","","","","","","","","","","","The paper only mention an effec on Hh by HIF-1, not the other way around",""
+"HIF-1 signaling pathway","Hedgehog signaling pathway","Hedgehog HIF-1 Pathway","22822532","yes","yes","activating","HIF1A","Q16665","UNIPROT","","","","Homo sapiens","heart","BTO:0000562","heart disease","Hypoxia conditions induce the expression up-regulation of hypoxia-induciblefactor-1 (HIF1), a transcription factor that modulates a varietyof gene expression, certainly including Hh signaling componentrelated genes","The paper is confusing and does not give much detail as to how the pathways interact, but it does say that HIF-1 has some transcriptional effect on Hh",""
+"Hedgehog signaling pathway","HIF-1 signaling pathway","Hedgehog HIF-1 Pathway","25187372","no","no","","","","","","","","","","","","","The full article was not read because the abstract barely mentions hedgehog and only by saying that the expression of Shh was linked to the expression of something else, but does not give any indication that Hh and HIF-1 interact",""
+"HIF-1 signaling pathway","Hedgehog signaling pathway","Hedgehog HIF-1 Pathway","25187372","no","no","","","","","","","","","","","","","The full article was not read because the abstract barely mentions hedgehog and only by saying that the expression of Shh was linked to the expression of something else, but does not give any indication that Hh and HIF-1 interact",""
+"Hedgehog signaling pathway","HIF-1 signaling pathway","Hedgehog HIF-1 Pathway","22885334","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned the two pathways in the context of them both playing some role in regulating glycolysis, but it didn't give any indications that they interact",""
+"HIF-1 signaling pathway","Hedgehog signaling pathway","Hedgehog HIF-1 Pathway","22885334","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned the two pathways in the context of them both playing some role in regulating glycolysis, but it didn't give any indications that they interact",""
+"Hedgehog signaling pathway","HIF-1 signaling pathway","Hedgehog HIF-1 Pathway","23856487","no","no","","","","","","","","","","","","","The full text was not read because the abstract barely mentioned HIF-1 and only talk about Hh by saying that it was inhibited using other treatments",""
+"HIF-1 signaling pathway","Hedgehog signaling pathway","Hedgehog HIF-1 Pathway","23856487","no","no","","","","","","","","","","","","","The full text was not read because the abstract barely mentioned HIF-1 and only talk about Hh by saying that it was inhibited using other treatments",""
+"Hedgehog signaling pathway","HIF-1 signaling pathway","Hedgehog HIF-1 Pathway","20840857","no","no","","","","","","","","","","","","","The text does not indicate that there is any effect on HIF-1 by Hh",""
+"HIF-1 signaling pathway","Hedgehog signaling pathway","Hedgehog HIF-1 Pathway","20840857","no","no","","","","","","","","","","","","","The text does say that hypoxia can activate the Hh pathway, but since it is not specific there wasn't enough evidence to identify any crosstalk",""
+"Hedgehog signaling pathway","HIF-1 signaling pathway","Hedgehog HIF-1 Pathway","18774959","no","no","","","","","","","","","","","","","The text does not mention any effect on HIF-1 by Hh",""
+"HIF-1 signaling pathway","Hedgehog signaling pathway","Hedgehog HIF-1 Pathway","18774959","yes","yes","activating","Hif1a","Q61221","UNIPROT","Shh","Q62226","UNIPROT","Mus musculus","cardiomyoblast","BTO:0001940","hypoxia","Our data confirm that hypoxia indeed leads to HIF-1α-dependent Shh expression and consequent Hh pathway activity.","The only crosstalk found was transcriptional",""
+"Hedgehog signaling pathway","HIF-1 signaling pathway","Hedgehog HIF-1 Pathway","22579961","no","no","","","","","","","","","","","","","The full article was not read because the abstract only briefly talks about hedgehog and only says that they both play some role in regulating cancer stem cells, but does not give any inclinations that they interact",""
+"HIF-1 signaling pathway","Hedgehog signaling pathway","Hedgehog HIF-1 Pathway","22579961","no","no","","","","","","","","","","","","","The full article was not read because the abstract only briefly talks about hedgehog and only says that they both play some role in regulating cancer stem cells, but does not give any inclinations that they interact",""
+"Hedgehog signaling pathway","HIF-1 signaling pathway","Hedgehog HIF-1 Pathway","18787973","no","no","","","","","","","","","","","","","The full paper was not read because in the abstract it mentions both pathways and their roles in testicular injuries, but their roles are carried out in different tissues so they most likely don't crosstalk",""
+"HIF-1 signaling pathway","Hedgehog signaling pathway","Hedgehog HIF-1 Pathway","18787973","no","no","","","","","","","","","","","","","The full paper was not read because in the abstract it mentions both pathways and their roles in testicular injuries, but their roles are carried out in different tissues so they most likely don't crosstalk",""
+"Hedgehog signaling pathway","HIF-1 signaling pathway","Hedgehog HIF-1 Pathway","21967331","no","no","","","","","","","","","","","","","The full article was not read because the abstract does not even mention Hh",""
+"HIF-1 signaling pathway","Hedgehog signaling pathway","Hedgehog HIF-1 Pathway","21967331","no","no","","","","","","","","","","","","","The full article was not read because the abstract does not even mention Hh",""
+"Hedgehog signaling pathway","HIF-1 signaling pathway","Hedgehog HIF-1 Pathway","18228117","no","no","","","","","","","","","","","","","The article mentions that there are two inhibitors that inhibit both pathways, but I wasn't sure if the inhibitors are actually part of the pathways so I said threre was no crosstalk. It also said that these inhibition could mean a complex crosstalk between the two, but does not give any more detail than that",""
+"HIF-1 signaling pathway","Hedgehog signaling pathway","Hedgehog HIF-1 Pathway","18228117","no","no","","","","","","","","","","","","","The article mentions that there are two inhibitors that inhibit both pathways, but I wasn't sure if the inhibitors are actually part of the pathways so I said threre was no crosstalk. It also said that these inhibition could mean a complex crosstalk between the two, but does not give any more detail than that",""
+"Hedgehog signaling pathway","Hippo signaling pathway","Hedgehog Hippo Crosstalk","23287077","no","no","","","","","","","","","","","","","The article talked about both pathways and how they may be involved in colon carcinogenesis, but it only mentions the crosstalk they have with other pathways",""
+"Hippo signaling pathway","Hedgehog signaling pathway","Hedgehog Hippo Crosstalk","23287077","no","no","","","","","","","","","","","","","The article talked about both pathways and how they may be involved in colon carcinogenesis, but it only mentions the crosstalk they have with other pathways",""
+"Hedgehog signaling pathway","Hippo signaling pathway","Hedgehog Hippo Cross-talk","25111861","yes","no","inhibiting","","","","YAP1","P46937","UNIPROT","Homo sapiens","pancreas","BTO:0000988","cancer","Concerning a positive modulation of YAP by Hh signaling, we found post-transcriptional mechanisms at play that increase the amounts of YAP protein","The text says that the exact molecular interactions of this relationship need further studies, but they state that is post-transcriptional, so it is most likely direct",""
+"Hippo signaling pathway","Hedgehog signaling pathway","Hedgehog Hippo Cross-talk","25111861","yes","no","activating","YAP1","P46937","UNIPROT","GLI1","P08151","UNIPROT","Homo sapiens","pancreas","BTO:0000988","cancer","Regarding the negative regulation, YAP can directly interact with GLI1 and can hypothetically interfere with the correct built-up of transcriptional complexes around GLI1.","The text is very clear in explaining the effect of YAP on Hh and explicetly explains the crosstalk",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Hedgehog Insulin Crosstalk","25804855","no","no","","","","","","","","","","","","","The full text was not read because it only mentioned both pathways separately as having different roles in the ""muscle-bone"" unit",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Hedgehog Insulin Crosstalk","25804855","no","no","","","","","","","","","","","","","The full text was not read because it only mentioned both pathways separately as having different roles in the ""muscle-bone"" unit",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Hedgehog Insulin Crosstalk","19714501","yes","no","activating","SHH","Q15465","UNIPROT","IRS1","P35568","UNIPROT","Homo sapiens","central nervous system","BTO:0000227","development","In addition, the interaction between Shh and IGF1R pathways may be bi-directional as suggested by the ability of Shh to stabilise IRS-1 by interfering with its mTOR-mediated degradation","The text suggests that there is evidence for bi-directional crosstalk, although it doesn't go into much detail",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Hedgehog Insulin Crosstalk","19714501","yes","yes","inhibiting","GSK3B","P49841","UNIPROT","SHH","Q15465","UNIPROT","Homo sapiens","central nervous system","BTO:0000227","development","Moreover, GSK3β itself can negatively regulate Shh-induced cell proliferation by inactivating N-myc, a proto-oncogene that is a direct transcriptional target of Shh and mediates its mitogenic effect","The only crosstalk found was transcriptional, and the article was clear about that interaction",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Hedgehog Insulin Cross-talk","24044950","no","no","","","","","","","","","","","","","The full paper was not read because there was no mention of insulin in the abstract",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Hedgehog Insulin Cross-talk","24044950","no","no","","","","","","","","","","","","","The full paper was not read because there was no mention of insulin in the abstract",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Hedgehog Insulin Cross-talk","20716670","no","no","","","","","","","","","","","","","The two pathways seemed to be connected somehow but any interactions seemed to be indirect",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Hedgehog Insulin Cross-talk","20716670","no","no","","","","","","","","","","","","","The two pathways seemed to be connected somehow but any interactions seemed to be indirect",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Hedgehog Insulin Cross-talk","21618536","yes","no","activating","SMO","Q99835","UNIPROT","IGF1R","P08069","UNIPROT","Homo sapiens","myoblast","BTO:0000222","differentiation","IGF-IR was found to associate with Smo in response to IGF-I","This sentence is in the context that IGF-IR associating with Smo results in maximal IGF-I signaling, which is why it is crosstalk from Hh to Insulin",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Hedgehog Insulin Cross-talk","21618536","no","no","","","","","","","","","","","","","The effect of Hh on IGF-I are ambiguous in this article, so it is hard to tell whether there is crosstalk or not",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Hedgehog Insulin Cross-talk","25599599","no","no","","","","","","","","","","","","","The full paper was not read because the article only talked about the crosstalk between each pathway and ErbB, not with each other",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Hedgehog Insulin Cross-talk","25599599","no","no","","","","","","","","","","","","","The full paper was not read because the article only talked about the crosstalk between each pathway and ErbB, not with each other",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Hedgehog Insulin Cross-talk","24681495","no","no","","","","","","","","","","","","","The full article could not be read because it was written in Japanese",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Hedgehog Insulin Cross-talk","24681495","no","no","","","","","","","","","","","","","The full article could not be read because it was written in Japanese",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Hedgehog Insulin Cross-talk","18854943","no","no","","","","","","","","","","","","","The abstract mentioned a potential crosstalk between the pathways, but the text didn't discuss the hedgehog pathway, or any crosstalk",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Hedgehog Insulin Cross-talk","18854943","no","no","","","","","","","","","","","","","The abstract mentioned a potential crosstalk between the pathways, but the text didn't discuss the hedgehog pathway, or any crosstalk",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Hedgehog Insulin Pathway","24548465","yes","yes","unknown","Gli3","Q61602","UNIPROT","Igf1","P05017","UNIPROT","Mus musculus","hepatocyte","BTO:0000575","normal","Indeed, two active GLI3 binding sites in the promoter region of the Igf1 gene have already been identified","The article does not give very comprehensive information on the relationship between GLI3 and Igf1 expression. It is said that there is a direct binding site, but it does not say if it is activating or repressing",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Hedgehog Insulin Pathway","24548465","no","no","","","","","","","","","","","","","There only appears to be crosstalk from Hh to Insulin and not the other way around",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Hedgehog Insulin Pathway","24533105","no","no","","","","","","","","","","","","","The text suggested that Shh upregulates IGF-1, but it only mentions it very briefly in the abstract and then does not give any more detail after that, so there is not enough information here",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Hedgehog Insulin Pathway","24533105","no","no","","","","","","","","","","","","","The text suggested that Shh upregulates IGF-1, but it only mentions it very briefly in the abstract and then does not give any more detail after that, so there is not enough information here",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Hedgehog Insulin Pathway","24572787","no","no","","","","","","","","","","","","","The paper only briefly mentions that Shh might regulate IGF-1, but it does not give any details or go in depth",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Hedgehog Insulin Pathway","24572787","no","no","","","","","","","","","","","","","The paper only briefly mentions that Shh might regulate IGF-1, but it does not give any details or go in depth",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Hedgehog Insulin Pathway","23781099","no","no","","","","","","","","","","","","","Again there is only brief mention of upregulation of IGF-1 by Shh, but it is not discussed and gives no detail",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Hedgehog Insulin Pathway","23781099","no","no","","","","","","","","","","","","","Again there is only brief mention of upregulation of IGF-1 by Shh, but it is not discussed and gives no detail",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Hedgehog Insulin Pathway","24846856","no","no","","","","","","","","","","","","","The article only mentions how each pathway has a role in sarcomatogenesis, but they are discussed separately and there is no mention of any interaction between the two",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Hedgehog Insulin Pathway","24846856","no","no","","","","","","","","","","","","","The article only mentions how each pathway has a role in sarcomatogenesis, but they are discussed separately and there is no mention of any interaction between the two",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Hedgehog Insulin Pathway","22213086","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed Hh, and didn't mention insulin",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Hedgehog Insulin Pathway","22213086","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed Hh, and didn't mention insulin",""
+"Hedgehog signaling pathway","Jak-STAT signaling pathway","Hedgehog Jak-STAT Pathway","23313126","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentioned Hedgehog and it only said that the distribution of Hegehog is regulated by HSPGs. It also says that HSPGs play a role in Jak-STAT signalling, but it gave no indication that there is any interaction between the two pathways",""
+"Jak-STAT signaling pathway","Hedgehog signaling pathway","Hedgehog Jak-STAT Pathway","23313126","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentioned Hedgehog and it only said that the distribution of Hegehog is regulated by HSPGs. It also says that HSPGs play a role in Jak-STAT signalling, but it gave no indication that there is any interaction between the two pathways",""
+"Hedgehog signaling pathway","Jak-STAT signaling pathway","Hedgehog Jak-STAT Pathway","25753035","yes","yes","activating","","","","upd2","Q9VWX2","UNIPROT","Drosophila melanogaster","intestine","BTO:0000648","injury","In search for Hh-regulated secreted proteins that mediate the effect of Hh signaling on ISC proliferation, we found that Hh pathway activation dramatically increased the expression of the JAK–STAT pathway ligand Upd2 as well as the pathway reporter gene 10XStat-dGFP","The only crosstalk mentioned was transcriptional, there was no direct interaction implied",""
+"Jak-STAT signaling pathway","Hedgehog signaling pathway","Hedgehog Jak-STAT Pathway","25753035","no","no","","","","","","","","","","","","","There was only crosstalk from Hedgehog to Jak-STAT, not Jak-STAT to Hedgehog",""
+"Hedgehog signaling pathway","Jak-STAT signaling pathway","Hedgehog Jak-STAT Pathway","25256290","no","no","","","","","","","","","","","","","The full paper was not read because the abstract states that Shh acts (in this context) independently of Jak-STAT",""
+"Jak-STAT signaling pathway","Hedgehog signaling pathway","Hedgehog Jak-STAT Pathway","25256290","no","no","","","","","","","","","","","","","The full paper was not read because the abstract states that Shh acts (in this context) independently of Jak-STAT",""
+"Hedgehog signaling pathway","Jak-STAT signaling pathway","Hedgehog Jak-STAT Pathway","25487280","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentions Hedgehog once, and says it is active in JAK inactive cells, so in this paper they would not crosstalk",""
+"Jak-STAT signaling pathway","Hedgehog signaling pathway","Hedgehog Jak-STAT Pathway","25487280","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentions Hedgehog once, and says it is active in JAK inactive cells, so in this paper they would not crosstalk",""
+"Hedgehog signaling pathway","Jak-STAT signaling pathway","Hedgehog Jak-STAT Pathway","23175633","no","no","","","","","","","","","","","","","The full text was not read because the abstract explicitely states that the two pathways act independently",""
+"Jak-STAT signaling pathway","Hedgehog signaling pathway","Hedgehog Jak-STAT Pathway","23175633","no","no","","","","","","","","","","","","","The full text was not read because the abstract explicitely states that the two pathways act independently",""
+"Hedgehog signaling pathway","Jak-STAT signaling pathway","Hedgehog Jak-STAT Pathway","25446360","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned each pathway once and said that they were regulated by the same thing, but they do not interact",""
+"Jak-STAT signaling pathway","Hedgehog signaling pathway","Hedgehog Jak-STAT Pathway","25446360","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned each pathway once and said that they were regulated by the same thing, but they do not interact",""
+"Hedgehog signaling pathway","Jak-STAT signaling pathway","Hedgehog Jak-STAT Pathway","20356821","no","no","","","","","","","","","","","","","The article was not read because the abstract said that expression of IHH could not be verified in the cells that were the focus of the study, and it was mainly about Jak/STAT",""
+"Jak-STAT signaling pathway","Hedgehog signaling pathway","Hedgehog Jak-STAT Pathway","20356821","no","no","","","","","","","","","","","","","The article was not read because the abstract said that expression of IHH could not be verified in the cells that were the focus of the study, and it was mainly about Jak/STAT",""
+"Hedgehog signaling pathway","Jak-STAT signaling pathway","Hedgehog Jak-STAT Pathway","25796381","no","no","","","","","","","","","","","","","The full paper was not read because both pathways are only discussed separately and there is no indication that they interact",""
+"Jak-STAT signaling pathway","Hedgehog signaling pathway","Hedgehog Jak-STAT Pathway","25796381","no","no","","","","","","","","","","","","","The full paper was not read because both pathways are only discussed separately and there is no indication that they interact",""
+"Hedgehog signaling pathway","Jak-STAT signaling pathway","Hedgehog Jak-STAT Pathway","19662079","no","no","","","","","","","","","","","","","The full text was not read because Hh isn't even mentioned in the abstract",""
+"Jak-STAT signaling pathway","Hedgehog signaling pathway","Hedgehog Jak-STAT Pathway","19662079","no","no","","","","","","","","","","","","","The full text was not read because Hh isn't even mentioned in the abstract",""
+"Hedgehog signaling pathway","Jak-STAT signaling pathway","Hedgehog Jak-STAT Pathway","25860240","no","no","","","","","","","","","","","","","The paper was not read because there was only mention of both pathways being potential therapeutic strategies for MF, but does not suggest that they interact",""
+"Jak-STAT signaling pathway","Hedgehog signaling pathway","Hedgehog Jak-STAT Pathway","25860240","no","no","","","","","","","","","","","","","The paper was not read because there was only mention of both pathways being potential therapeutic strategies for MF, but does not suggest that they interact",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Crosstalk","25355554","no","no","","","","","","","","","","","","","The text does not say that Hh affects MAPK",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Crosstalk","25355554","yes","yes","inhibiting","Egfr","Q01279","UNIPROT","Shh","Q62226","UNIPROT","Mus musculus","intestine","BTO:0000648","normal","EGFR/MAPK signaling inhibits Shh expression at the level of transcription according to our studies","There is no mention of any direct interactions between the pathways",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Crosstalk","20839260","no","no","","","","","","","","","","","","","The text describes many complex relationships but in the study there only seemed to be crosstalk between Hh and PI3K/Akt, and the article states that there wasn't a role for ERK/MAPK in Hh signaling, and that Hh may not be connected with ERK signaling pathway components. It does also say that Shh can activate the MAPK, but it does not go into any detail and there are many statements that say otherwise in the article",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Crosstalk","20839260","no","no","","","","","","","","","","","","","The text mentions many times that the hh pathway/Gli expression is affected by PI3/Akt but not MAPK, but then it goes on to say that ""MAPK and AKT can also reinforce the activation of Hh signaling at the level of the Gli transcription factors"" so it contradicts itself",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Crosstalk","25701761","no","no","","","","","","","","","","","","","There was only mention of crosstalk from MAPK to Hh",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Crosstalk","25701761","yes","no","inhibiting","PRKACA","P17612","UNIPROT","GLI1","P08151","UNIPROT","Homo sapiens","cartilage","BTO:0000206","development","the activation of PKA downregulates the function of Gli1, which consequently decreases the proliferation","The text does not go into much more detail than the one sentence, but it seems to be direct regulation. The text was confusing though because it only really talked about PKA and PACAP, not MAPK so the PKA that is interacting with Gli1 may not be part of the MAPK pathway",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Crosstalk","25701761","yes","no","inhibiting","PRKACA","P17612","UNIPROT","GLI1","P08151","UNIPROT","Homo sapiens","bone","BTO:0000140","development","the activation of PKA downregulates the function of Gli1, which consequently decreases the proliferation","The text does not go into much more detail than the one sentence, but it seems to be direct regulation. The text was confusing though because it only really talked about PKA and PACAP, not MAPK so the PKA that is interacting with Gli1 may not be part of the MAPK pathway",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Crosstalk","19855020","no","no","","","","","","","","","","","","","There did not seem to be any crosstalk from Hh to MAPK",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Crosstalk","19855020","yes","yes","unknown","","","","SHH","Q15465","UNIPROT","Homo sapiens","limb","BTO:0001492","development","Accordingly, using specific inhibitors for the ERK1/2-MAPK and the PI3K-Akt pathways, we show that the FGF induction of Shh (and also BMP genes) is mediated by the classical ERK1/2 MAPK transduction pathway","There is not much detail given about the interaction between Shh and MAPK, but the article seems to suggest that their interaction is direct and not transcriptional or mediated by something else",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Pathway","25110171","no","no","","","","","","","","","","","","","The text suggests that there may be a crosstalk between the two pathways, but it is only mentioned once with no evidence to support it",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Pathway","25110171","no","no","","","","","","","","","","","","","The text suggests that there may be a crosstalk between the two pathways, but it is only mentioned once with no evidence to support it",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Pathway","24027019","no","no","","","","","","","","","","","","","The full text was unavailable but was accessed from the vt lib page. The article wasn't very clear about the interactions between the two pathways. It seemed that hedgehog may interact with MAPK somehow, but the text was too ambiguous",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Pathway","24027019","no","no","","","","","","","","","","","","","The full text was unavailable but was accessed from the vt lib page. The article wasn't very clear about the interactions between the two pathways. It seemed that hedgehog may interact with MAPK somehow, but the text was too ambiguous",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Pathway","26053182","no","no","","","","","","","","","","","","","There was no mention of any crosstalk from Hh to MAPK",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Pathway","26053182","no","unknown","activating","","","","GLI2","P10070","UNIPROT","Homo sapiens","colonic cancer cell","BTO:0000586","cancer","More specifically, PI3K, MAPK and TGFβ signaling induce their effect, at least partially, through the activation of the GLI1/2 transcription factors","MAPK was only briefly mentioned but it does say that it activates GLI transcription factors",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Pathway","23271286","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that SHH had no effect on the MAPK pathway, and it does not mention any potential effects on Hh by MAPK either",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Pathway","23271286","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that SHH had no effect on the MAPK pathway, and it does not mention any potential effects on Hh by MAPK either",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Pathway","22543708","yes","yes","activating","","","","","","","Homo sapiens","hepatoma cell","BTO:0000608","cancer","These indicate that the Hh signal pathway is involved in human HCC invasion and metastasis by up-regulating the expression of MAPK/ERK pathway, instead of the MAPK/ERK pathway inducing expression of Gli1.","The paper did not go into very much detail about the effect of Hh on MAPK, but it does say it directly regulates the expression of MAPK",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Pathway","22543708","no","no","","","","","","","","","","","","","There seemed to be no indication that MAPK had any effect on Hh in this context",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Pathway","25848695","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were only mentioned very briefly and were mentioned separately, indicating they don't interact in this context",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Pathway","25848695","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were only mentioned very briefly and were mentioned separately, indicating they don't interact in this context",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Pathway","23599805","no","no","","","","","","","","","","","","","The full text was not read because the abstract said that a Hh-specific inhibitor modulated the MAPK signaling pathway, but that inhibitor is not part of the Hh pathway",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Pathway","23599805","no","no","","","","","","","","","","","","","The full text was not read because the abstract said that a Hh-specific inhibitor modulated the MAPK signaling pathway, but that inhibitor is not part of the Hh pathway",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Pathway","22391311","no","no","","","","","","","","","","","","","The full text was not read because in the abstract it only discusses that each is affected by arsenic, but does not say anything about them affecting each other",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Pathway","22391311","no","no","","","","","","","","","","","","","The full text was not read because in the abstract it only discusses that each is affected by arsenic, but does not say anything about them affecting each other",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Pathway","25037249","no","no","","","","","","","","","","","","","The full article was not read because in the abstract both pathways were only mentioned to say that they may have a tie to primary open-angle glaucoma, but it does not suggest that they interact at all",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Pathway","25037249","no","no","","","","","","","","","","","","","The full article was not read because in the abstract both pathways were only mentioned to say that they may have a tie to primary open-angle glaucoma, but it does not suggest that they interact at all",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Pathway","20160094","no","no","","","","","","","","","","","","","The full paper was not read because in the abstract it states that MAPK signaling (in this context) is initiated by N-cadherin ligation and not Shh",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Pathway","20160094","no","no","","","","","","","","","","","","","The full paper was not read because in the abstract it states that MAPK signaling (in this context) is initiated by N-cadherin ligation and not Shh",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Hedgehog MAPK Pathway","24303070","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses each pathway and how it reacts with Wnt, not how they might react with each other",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Hedgehog MAPK Pathway","24303070","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses each pathway and how it reacts with Wnt, not how they might react with each other",""
+"Hedgehog signaling pathway","Neurotrophin signaling pathway","Hedgehog Neurotrophin Pathway","23343527","no","no","","","","","","","","","","","","","The full article was not read because both pathways are only talked about in different contexts in the abstract and there are no clues that they communicate",""
+"Neurotrophin signaling pathway","Hedgehog signaling pathway","Hedgehog Neurotrophin Pathway","23343527","no","no","","","","","","","","","","","","","The full article was not read because both pathways are only talked about in different contexts in the abstract and there are no clues that they communicate",""
+"Hedgehog signaling pathway","Neurotrophin signaling pathway","Hedgehog Neurotrophin Pathway","11313044","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned that the expression of components of both pathways were measured after induced myopia, but does not mention any pathway interactions",""
+"Neurotrophin signaling pathway","Hedgehog signaling pathway","Hedgehog Neurotrophin Pathway","11313044","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned that the expression of components of both pathways were measured after induced myopia, but does not mention any pathway interactions",""
+"Hedgehog signaling pathway","Neurotrophin signaling pathway","Hedgehog NGF Pathway","24240054","no","no","","","","","","","","","","","","","The full text was not read because the article only mentions how each interacts with Stil, and does not say that they interact with each other",""
+"Neurotrophin signaling pathway","Hedgehog signaling pathway","Hedgehog NGF Pathway","24240054","no","no","","","","","","","","","","","","","The full text was not read because the article only mentions how each interacts with Stil, and does not say that they interact with each other",""
+"Hedgehog signaling pathway","Neurotrophin signaling pathway","Hedgehog NGF Pathway","23821040","no","no","","","","","","","","","","","","","The full article was not read because in the abstract both pathways are only discussed as being research methods for down syndrome, and does no indicate that they interact at all",""
+"Neurotrophin signaling pathway","Hedgehog signaling pathway","Hedgehog NGF Pathway","23821040","no","no","","","","","","","","","","","","","The full article was not read because in the abstract both pathways are only discussed as being research methods for down syndrome, and does no indicate that they interact at all",""
+"Hedgehog signaling pathway","Neurotrophin signaling pathway","Hedgehog BDNF Pathway","22031887","no","no","","","","","","","","","","","","","The two pathways do not seem to crosstalk in this context because the abstract states that Shh acts through miR-206 to affect BDNF",""
+"Neurotrophin signaling pathway","Hedgehog signaling pathway","Hedgehog BDNF Pathway","22031887","no","no","","","","","","","","","","","","","The two pathways do not seem to crosstalk in this context because the abstract states that Shh acts through miR-206 to affect BDNF",""
+"Hedgehog signaling pathway","Neurotrophin signaling pathway","Hedgehog BDNF Pathway","21345011","no","no","","","","","","","","","","","","","The full paper was not read because BDNF was not even mentioned in the abstract",""
+"Neurotrophin signaling pathway","Hedgehog signaling pathway","Hedgehog BDNF Pathway","21345011","no","no","","","","","","","","","","","","","The full paper was not read because BDNF was not even mentioned in the abstract",""
+"Hedgehog signaling pathway","Neurotrophin signaling pathway","Hedgehog BDNF Pathway","19422804","no","no","","","","","","","","","","","","","There only seemed to be interaction from BDNF to SHH",""
+"Neurotrophin signaling pathway","Hedgehog signaling pathway","Hedgehog BDNF Pathway","19422804","yes","yes","activating","Bdnf","P23363","UNIPROT","Shh","Q63673","UNIPROT","Rattus norvegicus","cerebral cortical neuron","BTO:0004102","normal","In our study, we demonstrated BDNF-induced up-regulation of SHH at both mRNA and protein levels","The paper only described increasing expression of SHH, not interacting with it directly",""
+"Hedgehog signaling pathway","Neurotrophin signaling pathway","Hedgehog BDNF Pathway","24150232","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses each pathway in a separate context",""
+"Neurotrophin signaling pathway","Hedgehog signaling pathway","Hedgehog BDNF Pathway","24150232","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses each pathway in a separate context",""
+"Hedgehog signaling pathway","Neurotrophin signaling pathway","Hedgehog BDNF Pathway","20848190","yes","yes","activating","SHH","Q15465","UNIPROT","BDNF","P23560","UNIPROT","Homo sapiens","brain","BTO:0000142","ischemia and neurodegenerative disorders","Pretreatment of the primary neuronal culture with SHH increased the expression of VEGF and BDNF dramatically","There wasn't much discussion on the details of how SHH upregulates BDNF, but it states that it does",""
+"Neurotrophin signaling pathway","Hedgehog signaling pathway","Hedgehog BDNF Pathway","20848190","no","no","","","","","","","","","","","","","There was only mention of interaction from SHH to BDNF",""
+"Hedgehog signaling pathway","Neurotrophin signaling pathway","Hedgehog BDNF Pathway","19261910","no","no","","","","","","","","","","","","","The full article was not read because the abstract only suggests that each pathway has some role in CNPs, but it does not say that they are connected",""
+"Neurotrophin signaling pathway","Hedgehog signaling pathway","Hedgehog BDNF Pathway","19261910","no","no","","","","","","","","","","","","","The full article was not read because the abstract only suggests that each pathway has some role in CNPs, but it does not say that they are connected",""
+"Hedgehog signaling pathway","Neurotrophin signaling pathway","Smoothened BDNF Pathway","25036590","no","no","","","","","","","","","","","","","The full text was not read because Hh was not even mentioned in the abstract",""
+"Neurotrophin signaling pathway","Hedgehog signaling pathway","Smoothened BDNF Pathway","25036590","no","no","","","","","","","","","","","","","The full text was not read because Hh was not even mentioned in the abstract",""
+"Hedgehog signaling pathway","NF-kappa B signaling pathway","Hedgehog NF-kappa B Cross-talk","23747884","no","no","","","","","","","","","","","","","The paper gave hints that there may crosstalk, but it did not discuss the actual crosstalk",""
+"NF-kappa B signaling pathway","Hedgehog signaling pathway","Hedgehog NF-kappa B Cross-talk","23747884","no","no","","","","","","","","","","","","","The paper gave hints that there may crosstalk, but it did not discuss the actual crosstalk",""
+"Hedgehog signaling pathway","NF-kappa B signaling pathway","Hedgehog NF-kappa B Cross-talk","22995915","no","no","","","","","","","","","","","","","There only seemed to be an effect on Hh by NF-kB",""
+"NF-kappa B signaling pathway","Hedgehog signaling pathway","Hedgehog NF-kappa B Cross-talk","22995915","yes","yes","activating","NFKB1","P19838","UNIPROT","SHH","Q15465","UNIPROT","Homo sapiens","macrophage","BTO:0000801","inflammatory response","NF-κB was recently shown to transcriptionally activate the mitogen sonic hedgehog (Shh) in inflammatory-stimulated macrophages","There didn't seem to be any direct interactions described",""
+"Hedgehog signaling pathway","NF-kappa B signaling pathway","Hedgehog NF-kappa B Cross-talk","20488613","no","no","","","","","","","","","","","","","The abstract suggested that there may have been potential crosstalk, but there is no mention of any pathway interactions in the text",""
+"NF-kappa B signaling pathway","Hedgehog signaling pathway","Hedgehog NF-kappa B Cross-talk","20488613","no","no","","","","","","","","","","","","","The abstract suggested that there may have been potential crosstalk, but there is no mention of any pathway interactions in the text",""
+"Hedgehog signaling pathway","NF-kappa B signaling pathway","Hedgehog NF-kappa B Pathway","22461522","yes","no","activating","SHH","Q15465","UNIPROT","NFKBIA","P25963","UNIPROT","Homo sapiens","colonic cancer cell","BTO:0000586","folate deprivation","The data suggest that regulation of NF-κB activation by Shh signaling could be compartmentalized in the cytosol, at least, at the IκBα degradation and subject to the FD-associated multistep regulatory process","The relationship from Shh to NF-kB is not very well defined, but from the text it semas that there is a direct interaction which degrades IkBa which promotes NF-kB activity",""
+"NF-kappa B signaling pathway","Hedgehog signaling pathway","Hedgehog NF-kappa B Pathway","22461522","yes","yes","activating","RELA","Q04206","UNIPROT","SHH","Q15465","UNIPROT","Homo sapiens","colonic cancer cell","BTO:0000586","folate deprivation","Enhanced binding of nuclear NF-κB p65 to the Shh promoter with increased transcript levels of Shh was shown in 6 h FD cells, followed by increased Shh protein production at 12 h","There didn't seem to be a direct effect from NF-kB to Hh, it only mentioned transcriptional effects",""
+"Hedgehog signaling pathway","NF-kappa B signaling pathway","Hedgehog NF-kappa B Pathway","23632891","yes","no","activating","SMO","Q99835","UNIPROT","PRKCB","P05771","UNIPROT","Homo sapiens","B-lymphocyte","BTO:0000776","lymphoma","In addition, our data indicate that the mechanistic link between SMO and NF-κB involves activation of PKCβ-1 and PKCβ-2 and the recruitment of CARMA1, BCL10, and MALT1 (CBM signalosome) to the SMO receptor complex","It states clearly that there are direct interactions from NF-kB pathway to SMO which helps to activate NF-kB signaling",""
+"NF-kappa B signaling pathway","Hedgehog signaling pathway","Hedgehog NF-kappa B Pathway","23632891","yes","yes","activating","RELA","Q04206","UNIPROT","SHH","Q15465","UNIPROT","Homo sapiens","B-lymphocyte","BTO:0000776","lymphoma","Recently, Kasperczyk and colleagues have demonstrated that SHH is a direct downstream target gene of NF-κB as p65 binds to the SHH promoter","The text states that there is complex bidirectional crosstalk, but the only crosstalk described in this direction is transcriptional",""
+"Hedgehog signaling pathway","NF-kappa B signaling pathway","Hedgehog NF-kappa B Pathway","23548480","no","no","","","","","","","","","","","","","The paper explains that the inhibition of the NFkB pathway sensitizes the cell to a Hh inhibitor, but it does not indicate that this is done directly, so there is not enough evidence to say there is crosstalk",""
+"NF-kappa B signaling pathway","Hedgehog signaling pathway","Hedgehog NF-kappa B Pathway","23548480","no","no","","","","","","","","","","","","","The paper explains that the inhibition of the NFkB pathway sensitizes the cell to a Hh inhibitor, but it does not indicate that this is done directly, so there is not enough evidence to say there is crosstalk",""
+"Hedgehog signaling pathway","NF-kappa B signaling pathway","Hedgehog NF-kappa B Pathway","23949847","no","no","","","","","","","","","","","","","The full text was not read because the abstract described the activity of the Hh pathway when the NFkB pathway had been disrupted, so there are no interactions mentioned",""
+"NF-kappa B signaling pathway","Hedgehog signaling pathway","Hedgehog NF-kappa B Pathway","23949847","no","no","","","","","","","","","","","","","The full text was not read because the abstract described the activity of the Hh pathway when the NFkB pathway had been disrupted, so there are no interactions mentioned",""
+"Hedgehog signaling pathway","NF-kappa B signaling pathway","Hedgehog NF-kappa B Pathway","22809693","no","no","","","","","","","","","","","","","There was no mention of any crosstalk from Hh to NFkB",""
+"NF-kappa B signaling pathway","Hedgehog signaling pathway","Hedgehog NF-kappa B Pathway","22809693","yes","yes","activating","NFKB1","P19838","UNIPROT","SHH","Q15465","UNIPROT","Homo sapiens","B-lymphocyte","BTO:0000776","lymphoma","Moreover, Kasperczyk and colleagues have provided evidence that SHH is a NF-kB target gene (under direct control of NF-kB) and promotes NF-kB mediated apoptosis resistance and tumor growth","There was only transcriptional interactions described",""
+"Hedgehog signaling pathway","NF-kappa B signaling pathway","Hedgehog NF-kappa B Pathway","25376721","no","no","","","","","","","","","","","","","The full paper was not read because Hh was not even mentioned in the abstract",""
+"NF-kappa B signaling pathway","Hedgehog signaling pathway","Hedgehog NF-kappa B Pathway","25376721","no","no","","","","","","","","","","","","","The full paper was not read because Hh was not even mentioned in the abstract",""
+"Hedgehog signaling pathway","NF-kappa B signaling pathway","Hedgehog NF-kappa B Pathway","24618907","no","no","","","","","","","","","","","","","The full text was not read because Hh was only mentioned once very briefly in the abstract and in a different context than NFkB",""
+"NF-kappa B signaling pathway","Hedgehog signaling pathway","Hedgehog NF-kappa B Pathway","24618907","no","no","","","","","","","","","","","","","The full text was not read because Hh was only mentioned once very briefly in the abstract and in a different context than NFkB",""
+"Hedgehog signaling pathway","NF-kappa B signaling pathway","Hedgehog NF-kappa B Pathway","24508088","no","no","","","","","","","","","","","","","The abstract suggested that there may have been crosstalk, but the text made no mention of it",""
+"NF-kappa B signaling pathway","Hedgehog signaling pathway","Hedgehog NF-kappa B Pathway","24508088","no","no","","","","","","","","","","","","","The abstract suggested that there may have been crosstalk, but the text made no mention of it",""
+"Hedgehog signaling pathway","NF-kappa B signaling pathway","Hedgehog NF-kappa B Pathway","20533175","no","no","","","","","","","","","","","","","The full text was not read because NF-kB was not mentioned in the abstract",""
+"NF-kappa B signaling pathway","Hedgehog signaling pathway","Hedgehog NF-kappa B Pathway","20533175","no","no","","","","","","","","","","","","","The full text was not read because NF-kB was not mentioned in the abstract",""
+"Hedgehog signaling pathway","NF-kappa B signaling pathway","Hedgehog NF-kappa B Pathway","21652647","no","no","","","","","","","","","","","","","The text mainly discussed interactions between Shh and the Eda pathway, and didn't really mention NF-kB very much",""
+"NF-kappa B signaling pathway","Hedgehog signaling pathway","Hedgehog NF-kappa B Pathway","21652647","no","no","","","","","","","","","","","","","The text mainly discussed interactions between Shh and the Eda pathway, and didn't really mention NF-kB very much",""
+"Hedgehog signaling pathway","Prolactin signaling pathway","Hedgehog Prolactin Pathway","12606279","no","no","","","","","","","","","","","","","The abstract suggested that there may be crosstalk, but the text was confusing about the relationship between Hh and Prolactin and was too ambiguous to determine that they crosstalk",""
+"Prolactin signaling pathway","Hedgehog signaling pathway","Hedgehog Prolactin Pathway","12606279","no","no","","","","","","","","","","","","","The abstract suggested that there may be crosstalk, but the text was confusing about the relationship between Hh and Prolactin and was too ambiguous to determine that they crosstalk",""
+"Hedgehog signaling pathway","Prolactin signaling pathway","Hedgehog Prolactin Pathway","16518860","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentioned prolactin and did not mention any potential interaction between Hh and prolactin",""
+"Prolactin signaling pathway","Hedgehog signaling pathway","Hedgehog Prolactin Pathway","16518860","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentioned prolactin and did not mention any potential interaction between Hh and prolactin",""
+"Hedgehog signaling pathway","Prolactin signaling pathway","Hedgehog RANKL Crosstalk","22479615","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses each pathway and its role in breast cancer, but does not suggest that they interact at all",""
+"Prolactin signaling pathway","Hedgehog signaling pathway","Hedgehog RANKL Crosstalk","22479615","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses each pathway and its role in breast cancer, but does not suggest that they interact at all",""
+"Hedgehog signaling pathway","Prolactin signaling pathway","Hedgehog RANKL Pathway","20081366","no","no","","","","","","","","","","","","","The full paper was not read because RANKL was not mentioned in the abstract",""
+"Prolactin signaling pathway","Hedgehog signaling pathway","Hedgehog RANKL Pathway","20081366","no","no","","","","","","","","","","","","","The full paper was not read because RANKL was not mentioned in the abstract",""
+"Hedgehog signaling pathway","Prolactin signaling pathway","Hedgehog RANKL Pathway","18477444","no","no","","","","","","","","","","","","","The full article was not read because RANKL is not mentioned in the abstract",""
+"Prolactin signaling pathway","Hedgehog signaling pathway","Hedgehog RANKL Pathway","18477444","no","no","","","","","","","","","","","","","The full article was not read because RANKL is not mentioned in the abstract",""
+"Hedgehog signaling pathway","Prolactin signaling pathway","Hedgehog RANKL Pathway","23592762","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned each pathway separately and gave no indication that they interact at all",""
+"Prolactin signaling pathway","Hedgehog signaling pathway","Hedgehog RANKL Pathway","23592762","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned each pathway separately and gave no indication that they interact at all",""
+"Hedgehog signaling pathway","Prolactin signaling pathway","Hedgehog RANKL Pathway","15380242","no","no","","","","","","","","","","","","","The full text was not read because RANKL was not mentioned in the abstract",""
+"Prolactin signaling pathway","Hedgehog signaling pathway","Hedgehog RANKL Pathway","15380242","no","no","","","","","","","","","","","","","The full text was not read because RANKL was not mentioned in the abstract",""
+"Hedgehog signaling pathway","TGF-beta signaling pathway","Hedgehog TGF-beta Crosstalk","23922933","no","no","","","","","","","","","","","","","The text states that Shh had no effect on TGF-beta",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","23922933","yes","yes","activating","TGFB1","P01137","UNIPROT","SHH","Q15465","UNIPROT","Homo sapiens","gingiva","BTO:0000519","proliferation","Exogenous TGF-β enhanced expression of Shh signaling molecules","There were no direct interactions described, only transcriptional ones",""
+"Hedgehog signaling pathway","TGF-beta signaling pathway","Hedgehog TGF-beta Crosstalk","22609357","yes","yes","activating","","","","","","","Homo sapiens","stomach","BTO:0001307","cancer","HH signaling induces the expression of TGF-β family members","This portion of the article was not very clear. It says that the TGF-beta family members are ""likely to be involved in SMO-dependent tumorigenesis, as Shh-induced cell motility and invasiveness requires TGF-β-driven activation of the SMAD pathway"" and that ""TGF-β is critical for SMO-mediated cancer development"" but neither of these statements suggest a direct interaction, so I'm assuming it is only transcriptional. No mechanism is provided so the crosstalk is ambiguous",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","22609357","yes","yes","activating","SMAD3:SMAD4,CTNNB1","P84022:Q13485,P35222","UNIPROT","GLI2","P10070","UNIPROT","Homo sapiens","many","","cancer","The capacity of TGF-β to rapidly induce GLI2 expression, even in the presence of cycloheximide, suggested that GLI2 is a direct target of SMADs, and did not require protein neosynthesis to occur","The text clearly explains and diagram that the SMAD3/4 complex directly binds to the Gli2 promoter and induces transcription",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","22609357","yes","yes","activating","TGFB1","P01137","UNIPROT","SHH","Q15465","UNIPROT","Homo sapiens","lung","BTO:0000763","cancer","The authors showed that TGF-β induced SHH expression in these cells, which in turn activated GLI1 and GLI1-dependent EMT","The text does not explain exactly how this transcriptional activation works, but it seems clear that TGF-beta has a direct effect on the transcription of Shh",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","22609357","yes","no","activating","TGFB1","P01137","UNIPROT","PRKACA","P17612","UNIPROT","Homo sapiens","lung","BTO:0000763","cancer","Inversely, we recently showed that TGF-β inhibits PKA activity while concomitantly inducing GLI2 and GLI1 expression","The text states that TGF-beta inhibits PKA, and since PKA is an inhibitor of the Hh pathway, that helps the activity of the Hh pathway",""
+"Hedgehog signaling pathway","TGF-beta signaling pathway","Hedgehog TGF-beta Crosstalk","25140582","yes","yes","activating","","","","","","","Homo sapiens","lung","BTO:0000763","fibrosis","Although SHH was undetectable in lung fibroblasts, these cells expressed elevated levels of TGF-beta upon treatment with SHH","The text states that SHH has an upregulating effect on TGF-beta expression, but provides no mechanism. The full text was not available through PubMed but it was available through the library and has been saved",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","25140582","no","no","","","","","","","","","","","","","The text suggested that TGF-beta has an effect on SHH expression, but did not provide any details or evidence. The full text was not available through PubMed but it was available through the library and has been saved",""
+"Hedgehog signaling pathway","TGF-beta signaling pathway","Hedgehog TGF-beta Crosstalk","20519943","no","no","","","","","","","","","","","","","The abstract suggested that TGF-beta and Hh cooperate to induce EMT, but the text mainly talks about the crosstalk between TGF-beta and Wnt/Ras, so there is no evidence in the text that TGF-beta and Hh crosstalk",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","20519943","no","no","","","","","","","","","","","","","The abstract suggested that TGF-beta and Hh cooperate to induce EMT, but the text mainly talks about the crosstalk between TGF-beta and Wnt/Ras, so there is no evidence in the text that TGF-beta and Hh crosstalk",""
+"Hedgehog signaling pathway","TGF-beta signaling pathway","Hedgehog TGF-beta Crosstalk","24104551","no","no","","","","","","","","","","","","","The full text was not read because the abstract mainly describes ER, and mentions cooperation between TGF-beta and Wnt, and mentions Hh briefly in a different context",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","24104551","no","no","","","","","","","","","","","","","The full text was not read because the abstract mainly describes ER, and mentions cooperation between TGF-beta and Wnt, and mentions Hh briefly in a different context",""
+"Hedgehog signaling pathway","TGF-beta signaling pathway","Hedgehog TGF-beta Crosstalk","23973264","no","no","","","","","","","","","","","","","The full text was not read becaus the abstract doesn't mention either pathway, it only talks about Notch",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","23973264","no","no","","","","","","","","","","","","","The full text was not read becaus the abstract doesn't mention either pathway, it only talks about Notch",""
+"Hedgehog signaling pathway","TGF-beta signaling pathway","Hedgehog TGF-beta Crosstalk","24870835","no","no","","","","","","","","","","","","","The full article could not be read because it was written in Japanese",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","24870835","no","no","","","","","","","","","","","","","The full article could not be read because it was written in Japanese",""
+"Hedgehog signaling pathway","TGF-beta signaling pathway","Hedgehog TGF-beta Crosstalk","25249658","no","no","","","","","","","","","","","","","The abstract suggested that there was crosstalk, but the text mainly describes crosstalk between TGF-beta and other pathways, and doesn't really discuss hedgehog",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","25249658","no","no","","","","","","","","","","","","","The abstract suggested that there was crosstalk, but the text mainly describes crosstalk between TGF-beta and other pathways, and doesn't really discuss hedgehog",""
+"Hedgehog signaling pathway","TGF-beta signaling pathway","Hedgehog TGF-beta Crosstalk","24944998","no","no","","","","","","","","","","","","","The abtsract mentioned the potential for crosstalk between pathways, but the text doesn't mention any crosstalk",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","24944998","no","no","","","","","","","","","","","","","The abtsract mentioned the potential for crosstalk between pathways, but the text doesn't mention any crosstalk",""
+"Hedgehog signaling pathway","TGF-beta signaling pathway","Hedgehog TGF-beta Crosstalk","22876389","no","no","","","","","","","","","","","","","The abstract seemed to suggest that there was crosstalk, but there was none found in the paper",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","22876389","no","no","","","","","","","","","","","","","The abstract seemed to suggest that there was crosstalk, but there was none found in the paper",""
+"Hedgehog signaling pathway","TGF-beta signaling pathway","Hedgehog TGF-beta Crosstalk","24829106","no","no","","","","","","","","","","","","","The text only discussed crosstalk between notch and wnt, and only mentioned TGF-beta and Hh briefly",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","24829106","no","no","","","","","","","","","","","","","The text only discussed crosstalk between notch and wnt, and only mentioned TGF-beta and Hh briefly",""
+"Hedgehog signaling pathway","TGF-beta signaling pathway","Hedgehog TGF-beta Crosstalk","25815127","no","no","","","","","","","","","","","","","The text only describes each pathway and does not mention any crosstalk between them",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","25815127","no","no","","","","","","","","","","","","","The text only describes each pathway and does not mention any crosstalk between them",""
+"Hedgehog signaling pathway","TGF-beta signaling pathway","Hedgehog TGF-beta Crosstalk","21552419","no","no","","","","","","","","","","","","","The text only describes each pathway and does not mention any crosstalk between them",""
+"TGF-beta signaling pathway","Hedgehog signaling pathway","Hedgehog TGF-beta Crosstalk","21552419","no","no","","","","","","","","","","","","","The text only describes each pathway and does not mention any crosstalk between them",""
+"Hedgehog signaling pathway","TNF signaling pathway","Hedgehog TNF Crosstalk","22439934","no","no","","","","","","","","","","","","","The text explains that TNFalpha has some kind of effect on Hh, but it is through mTOR and not direct",""
+"TNF signaling pathway","Hedgehog signaling pathway","Hedgehog TNF Crosstalk","22439934","no","no","","","","","","","","","","","","","The text explains that TNFalpha has some kind of effect on Hh, but it is through mTOR and not direct",""
+"Hedgehog signaling pathway","TNF signaling pathway","Hedgehog TNF Crosstalk","21973075","no","no","","","","","","","","","","","","","The article was mainly about crosstalk between SHH and Wnt and barely mentioned TNF",""
+"TNF signaling pathway","Hedgehog signaling pathway","Hedgehog TNF Crosstalk","21973075","no","no","","","","","","","","","","","","","The article was mainly about crosstalk between SHH and Wnt and barely mentioned TNF",""
+"Hedgehog signaling pathway","TNF signaling pathway","Hedgehog TNF Pathway","25701499","no","no","","","","","","","","","","","","","The paper suggests that there is some correlation between TNF and Hh, but it says in the text that the study does not answer the question as to how this is",""
+"TNF signaling pathway","Hedgehog signaling pathway","Hedgehog TNF Pathway","25701499","no","no","","","","","","","","","","","","","The paper suggests that there is some correlation between TNF and Hh, but it says in the text that the study does not answer the question as to how this is",""
+"Hedgehog signaling pathway","TNF signaling pathway","Hedgehog TNF Pathway","25406358","no","no","","","","","","","","","","","","","There was only evidence of crosstalk from TNF to Hh",""
+"TNF signaling pathway","Hedgehog signaling pathway","Hedgehog TNF Pathway","25406358","yes","yes","activating","","","","","","","Homo sapiens","umbilical vein endothelium","BTO:0001416","normal","The data show that Shh and Smo mRNA and protein levels markedly increased after treatment with TNF-α","The article is not very clear on the relationship between TNF and Shh, so the crosstalk was hard to find. Transcriptional crosstalk is suggested but no mechanism is provided, so the crosstalk is ambiguous",""
+"Hedgehog signaling pathway","TNF signaling pathway","Hedgehog TNF Pathway","25645065","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentioned TNF and in a different context than Hh",""
+"TNF signaling pathway","Hedgehog signaling pathway","Hedgehog TNF Pathway","25645065","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentioned TNF and in a different context than Hh",""
+"Hedgehog signaling pathway","TNF signaling pathway","Hedgehog TNF Pathway","24476135","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentioned TNF and in a different context than Hh",""
+"TNF signaling pathway","Hedgehog signaling pathway","Hedgehog TNF Pathway","24476135","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentioned TNF and in a different context than Hh",""
+"Hedgehog signaling pathway","TNF signaling pathway","Hedgehog TNF Pathway","25939425","no","no","","","","","","","","","","","","","The text explains TNF-alpha as an inflammatory response and only discusses both pathways in the context of how they are induced by UVB, but it does not give any evidence that they interact. There is a suggestion that one might affect the other but it is not backed with any evidence or details",""
+"TNF signaling pathway","Hedgehog signaling pathway","Hedgehog TNF Pathway","25939425","no","no","","","","","","","","","","","","","The text explains TNF-alpha as an inflammatory response and only discusses both pathways in the context of how they are induced by UVB, but it does not give any evidence that they interact. There is a suggestion that one might affect the other but it is not backed with any evidence or details",""
+"Hedgehog signaling pathway","TNF signaling pathway","Hedgehog TNF Pathway","23632891","no","no","","","","","","","","","","","","","The full paper was not read because TNF was not mentioned in the abstract",""
+"TNF signaling pathway","Hedgehog signaling pathway","Hedgehog TNF Pathway","23632891","no","no","","","","","","","","","","","","","The full paper was not read because TNF was not mentioned in the abstract",""
+"Hedgehog signaling pathway","TNF signaling pathway","Hedgehog TNF Pathway","23023967","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses both pathways and their potential roles in apoptosis, but it does no suggest that they interact at all",""
+"TNF signaling pathway","Hedgehog signaling pathway","Hedgehog TNF Pathway","23023967","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses both pathways and their potential roles in apoptosis, but it does no suggest that they interact at all",""
+"Hedgehog signaling pathway","TNF signaling pathway","Hedgehog TNF Pathway","23703673","no","no","","","","","","","","","","","","","The full article was not read because TNF is not mentioned in the abstract",""
+"TNF signaling pathway","Hedgehog signaling pathway","Hedgehog TNF Pathway","23703673","no","no","","","","","","","","","","","","","The full article was not read because TNF is not mentioned in the abstract",""
+"Hedgehog signaling pathway","TNF signaling pathway","Hedgehog TNF Pathway","25446360","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses that both pathways are regulated by some other factor but it does not suggest at all that the they crosstalk",""
+"TNF signaling pathway","Hedgehog signaling pathway","Hedgehog TNF Pathway","25446360","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses that both pathways are regulated by some other factor but it does not suggest at all that the they crosstalk",""
+"Hedgehog signaling pathway","TNF signaling pathway","Hedgehog TNF Pathway","25009639","no","no","","","","","","","","","","","","","The text explains that TNF has some kind of effect on Gli2, but it is through TGF-beta and does not seem to be direct",""
+"TNF signaling pathway","Hedgehog signaling pathway","Hedgehog TNF Pathway","25009639","no","no","","","","","","","","","","","","","The text explains that TNF has some kind of effect on Gli2, but it is through TGF-beta and does not seem to be direct",""
+"Hedgehog signaling pathway","TNF signaling pathway","Hedgehog TNF Pathway","21483830","no","no","","","","","","","","","","","","","The full text was not read because TNF is not mentioned in the abstract",""
+"TNF signaling pathway","Hedgehog signaling pathway","Hedgehog TNF Pathway","21483830","no","no","","","","","","","","","","","","","The full text was not read because TNF is not mentioned in the abstract",""
+"Hedgehog signaling pathway","Toll-like receptor signaling pathway","Hedgehog Toll-like receptor Pathway","23981041","no","no","","","","","","","","","","","","","The full text was not read because there was only very brief mention of both pathways in the abstract and they were both in different contexts",""
+"Toll-like receptor signaling pathway","Hedgehog signaling pathway","Hedgehog Toll-like receptor Pathway","23981041","no","no","","","","","","","","","","","","","The full text was not read because there was only very brief mention of both pathways in the abstract and they were both in different contexts",""
+"Hedgehog signaling pathway","Toll-like receptor signaling pathway","Hedgehog Toll-like receptor Pathway","23995793","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that effects on Hh are not dependent on TLR and TLR is not mentioned again",""
+"Toll-like receptor signaling pathway","Hedgehog signaling pathway","Hedgehog Toll-like receptor Pathway","23995793","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that effects on Hh are not dependent on TLR and TLR is not mentioned again",""
+"Hedgehog signaling pathway","Toll-like receptor signaling pathway","Hedgehog Toll-like receptor Pathway","22046349","no","no","","","","","","","","","","","","","This article was very confusing so it is very hard to tell if there was crosstalk or not. The interactions/relationships between Hh and TLR are much too ambiguous to determine crosstalk",""
+"Toll-like receptor signaling pathway","Hedgehog signaling pathway","Hedgehog Toll-like receptor Pathway","22046349","no","no","","","","","","","","","","","","","This article was very confusing so it is very hard to tell if there was crosstalk or not. The interactions/relationships between Hh and TLR are much too ambiguous to determine crosstalk",""
+"Hedgehog signaling pathway","Toll-like receptor signaling pathway","Hedgehog Toll-like receptor Pathway","25594066","no","no","","","","","","","","","","","","","The full text was not read because the abstract states that the effects on Hh are independent of TLR signaling",""
+"Toll-like receptor signaling pathway","Hedgehog signaling pathway","Hedgehog Toll-like receptor Pathway","25594066","no","no","","","","","","","","","","","","","The full text was not read because the abstract states that the effects on Hh are independent of TLR signaling",""
+"Hedgehog signaling pathway","Toll-like receptor signaling pathway","Hedgehog Toll-like receptor Pathway","25568859","no","no","","","","","","","","","","","","","The full paper was not read because the abstract discusses the pathways as having different roles in the inflammatory response",""
+"Toll-like receptor signaling pathway","Hedgehog signaling pathway","Hedgehog Toll-like receptor Pathway","25568859","no","no","","","","","","","","","","","","","The full paper was not read because the abstract discusses the pathways as having different roles in the inflammatory response",""
+"Hedgehog signaling pathway","Toll-like receptor signaling pathway","Hedgehog Toll-like receptor Pathway","21131441","no","no","","","","","","","","","","","","","There only seemed to be an effect on Hh by LPS",""
+"Toll-like receptor signaling pathway","Hedgehog signaling pathway","Hedgehog Toll-like receptor Pathway","21131441","no","yes","activating","","","","","","","Mus musculus","macrophage","BTO:0000801","normal","We have also observed activation of Hedgehog signaling at the transcriptional level in RAW264.7 macrophages upon LPS stimulation","This is really the only evidence provided of the response that Hh has to LPS. *Sarah and Murali: does not appear to be enough evidence; observation that LPS stimulates TLR4 and observation that LPS regulates Hedgehog expression seem to be independently stated.",""
+"Hedgehog signaling pathway","Toll-like receptor signaling pathway","Hedgehog Toll-like receptor Pathway","24229693","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only mentioned in a list of many pathways that may relate in some way to miRNA",""
+"Toll-like receptor signaling pathway","Hedgehog signaling pathway","Hedgehog Toll-like receptor Pathway","24229693","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only mentioned in a list of many pathways that may relate in some way to miRNA",""
+"Hedgehog signaling pathway","Toll-like receptor signaling pathway","Hedgehog Toll-like receptor Pathway","15711203","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentions that hh is a growth factor system and TLR has a role in the immune system",""
+"Toll-like receptor signaling pathway","Hedgehog signaling pathway","Hedgehog Toll-like receptor Pathway","15711203","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentions that hh is a growth factor system and TLR has a role in the immune system",""
+"Hedgehog signaling pathway","Toll-like receptor signaling pathway","Hedgehog Toll-like receptor Pathway","19549813","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only talks about both pathways being modulated by copper",""
+"Toll-like receptor signaling pathway","Hedgehog signaling pathway","Hedgehog Toll-like receptor Pathway","19549813","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only talks about both pathways being modulated by copper",""
+"Hedgehog signaling pathway","Toll-like receptor signaling pathway","Hedgehog Toll-like receptor Pathway","11793244","no","no","","","","","","","","","","","","","The full text was not read because each pathway is only mentioned as a pathway that dictates pattern in Drosophila",""
+"Toll-like receptor signaling pathway","Hedgehog signaling pathway","Hedgehog Toll-like receptor Pathway","11793244","no","no","","","","","","","","","","","","","The full text was not read because each pathway is only mentioned as a pathway that dictates pattern in Drosophila",""
+"Hedgehog signaling pathway","Toll-like receptor signaling pathway","Gli Toll-like Receptor Pathway","24733511","no","no","","","","","","","","","","","","","The full article was not read because the abstract did not mention Hh or Gli",""
+"Toll-like receptor signaling pathway","Hedgehog signaling pathway","Gli Toll-like Receptor Pathway","24733511","no","no","","","","","","","","","","","","","The full article was not read because the abstract did not mention Hh or Gli",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Crosstalk","23762360","no","no","","","","","","","","","","","","","The full text was not read because VEGF was only very briefly mentioned and in a different context than Hh",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Crosstalk","23762360","no","no","","","","","","","","","","","","","The full text was not read because VEGF was only very briefly mentioned and in a different context than Hh",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Crosstalk","23973264","no","no","","","","","","","","","","","","","The full text was not read because neither pathway was mentioned in the abstract, only notch",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Crosstalk","23973264","no","no","","","","","","","","","","","","","The full text was not read because neither pathway was mentioned in the abstract, only notch",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Pathway","22513894","yes","yes","activating","","","","VEGFA","P67964","UNIPROT","Gallus gallus","blood vessel","BTO:0001102","embryo/development","Stimulation of Hh signaling results in upregulation of VEGFA expression levels","The text does not go into very much detail about the relationship between Hh and VEGF but it does seem like Hh has some direct activation of VEGFA expression",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Pathway","22513894","no","no","","","","","","","","","","","","","The text only mentions an effect on VEGF by Hh",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Pathway","25187372","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentions both pathways and their relation to diabetes, and does not suggest that they interact at all",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Pathway","25187372","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentions both pathways and their relation to diabetes, and does not suggest that they interact at all",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Pathway","24450438","no","no","","","","","","","","","","","","","The full article was not read because the abstract only very briefly VEGF and in a different context than Hh",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Pathway","24450438","no","no","","","","","","","","","","","","","The full article was not read because the abstract only very briefly VEGF and in a different context than Hh",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Pathway","22668851","no","no","","","","","","","","","","","","","The text is very confusing about the relationship between VEGF and Hh, but the article seems to suggest that in this context they act independently of each other",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Pathway","22668851","no","no","","","","","","","","","","","","","The text is very confusing about the relationship between VEGF and Hh, but the article seems to suggest that in this context they act independently of each other",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Pathway","23129257","yes","yes","activating","Gli1","P47806","UNIPROT","Vegfa/Vegfb/Vegfc","Q00731/P49766/P97953","UNIPROT","Mus musculus","pancreas","BTO:0000988","cancer stem cells","The protein expression of downstream targets of Gli transcription, Oct4, Nanog, PDGFRα, and VEGF was further confirmed by immunohistochemistry of the mice tissues obtained from both the groups","The text does not really give much detail as to the nature of this relationship but it seems that Gli directly activates transcription of VEGF",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Pathway","23129257","no","no","","","","","","","","","","","","","There was only an effect on VEGF by Hh mentioned",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Pathway","23287320","yes","yes","activating","GLI1","P08151","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","glial cell","BTO:0002606","glioma","The data showed that Gli1 inhibition can indeed down-regulate mRNA and protein expressions of VEGF, MMP2, and MMP9.","There was not much detail provided but it seems that Gli has a transcriptional effect on VEGF",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Pathway","23287320","no","no","","","","","","","","","","","","","There was only an effect on VEGF by Hh mentioned",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Pathway","25141859","no","no","","","","","","","","","","","","","The paper seemed to suggest that there may be a correlation between the two, but it is too ambiguous to tell if there is interaction or not",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Pathway","25141859","no","no","","","","","","","","","","","","","The paper seemed to suggest that there may be a correlation between the two, but it is too ambiguous to tell if there is interaction or not",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Pathway","23378030","yes","yes","activating","SHH","Q15465","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","astrocyte","BTO:0000099","oxygen-glucose deprived","Our findings demonstrated that exogenous Shh also increased the VEGF, Ang-1, and Ang-2 expressions","The text only mentions transcriptional regulation, but no direct protein-protein interactions",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Pathway","23378030","no","no","","","","","","","","","","","","","There was only an effect on VEGF by Hh mentioned",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Pathway","24917971","yes","yes","activating","","","","VEGFA","P15692","UNIPROT","Homo sapiens","liver","BTO:0000759","HCC","Notably, these studies reported that Hh signalling may not directly affect endothelial cells in terms of viability and migration but rather increases the expression of proangiogenic cytokines, in particular VEGF","The text only mentions transcriptional regulation, but no direct protein-protein interactions",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Pathway","24917971","no","no","","","","","","","","","","","","","There was only an effect on VEGF by Hh mentioned",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Pathway","25581613","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentions VEGF and in a different context than Hh",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Pathway","25581613","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentions VEGF and in a different context than Hh",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Pathway","21305477","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discussed the effect of both pathways on bone vascularization and didn't suggest that they interact",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Pathway","21305477","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discussed the effect of both pathways on bone vascularization and didn't suggest that they interact",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Pathway","21597001","yes","yes","activating","","","","","","","Homo sapiens","pericyte","BTO:0002441","tumor angiogenesis","Our data show that for some tumor types, Hh's predominant tumor-promoting effect is through the induction of stromal VEGF-A","The text does not clearly state whether the crosstalk is transcriptional or not, but based on the paper it doesn't seem to suggest a direct protein-protein interaction. No mechanism is provided so the crosstalk is ambiguous",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Pathway","21597001","no","no","","","","","","","","","","","","","There was only an effect on VEGF by Hh mentioned",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Pathway","20339091","yes","yes","activating","","","","VEGFA","P15692","UNIPROT","Homo sapiens","vascular cell","BTO:0002688","development","We found that Hh was required for the expression of VEGF specifically in those regions of the embryo in which Hh was necessary for artery/vein identity and endothelial tube formation","The text only mentions transcriptional regulation, but no direct protein-protein interactions",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Pathway","20339091","no","no","","","","","","","","","","","","","There was only an effect on VEGF by Hh mentioned",""
+"Hedgehog signaling pathway","VEGF signaling pathway","Hedgehog VEGF Pathway","19407245","yes","yes","activating","SHH","Q15465","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","vascular smooth muscle","BTO:0001431","normal","In adult blood vessels, Shh is angiogenic in the ischemic hindlimb, stimulates the production of angiogenic factors, including VEGF-A","The text only mentions transcriptional regulation, but no direct protein-protein interactions",""
+"VEGF signaling pathway","Hedgehog signaling pathway","Hedgehog VEGF Pathway","19407245","no","no","","","","","","","","","","","","","There was only an effect on VEGF by Hh mentioned",""
+"Notch signaling pathway","Melanogenesis","Hairless Melanogenesis Pathway","23769841","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discussed hairless mice, not hairless in relation to the Notch pathway",""
+"Melanogenesis","Notch signaling pathway","Hairless Melanogenesis Pathway","23769841","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discussed hairless mice, not hairless in relation to the Notch pathway",""
+"Notch signaling pathway","Melanogenesis","Hairless Melanogenesis Pathway","23088959","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discussed hairless mice, not hairless in relation to the Notch pathway",""
+"Melanogenesis","Notch signaling pathway","Hairless Melanogenesis Pathway","23088959","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discussed hairless mice, not hairless in relation to the Notch pathway",""
+"Notch signaling pathway","Melanogenesis","Notch Melanogenesis","20146711","no","no","","","","","","","","","","","","","The full text was not read because Notch was not even mentioned in the abstract",""
+"Melanogenesis","Notch signaling pathway","Notch Melanogenesis","20146711","no","no","","","","","","","","","","","","","The full text was not read because Notch was not even mentioned in the abstract",""
+"Notch signaling pathway","Melanogenesis","Notch Melanogenesis","18787413","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned that both pathways are regulated by c-kit, and does not give any suggestion that they interact at all",""
+"Melanogenesis","Notch signaling pathway","Notch Melanogenesis","18787413","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned that both pathways are regulated by c-kit, and does not give any suggestion that they interact at all",""
+"Notch signaling pathway","Melanogenesis","Notch MSH Pathway","24227653","no","no","","","","","","","","","","","","","The full text was not read because MSH was not mentioned in the abstract",""
+"Melanogenesis","Notch signaling pathway","Notch MSH Pathway","24227653","no","no","","","","","","","","","","","","","The full text was not read because MSH was not mentioned in the abstract",""
+"Notch signaling pathway","Progesterone-mediated oocyte maturation","Notch Progesterone Crosstalk","25001242","no","no","","","","","","","","","","","","","The text mainly discusses crosstalk between Notch and other pathways, not progesterone",""
+"Progesterone-mediated oocyte maturation","Notch signaling pathway","Notch Progesterone Crosstalk","25001242","no","no","","","","","","","","","","","","","The text mainly discusses crosstalk between Notch and other pathways, not progesterone",""
+"Notch signaling pathway","Progesterone-mediated oocyte maturation","Notch Progesterone Cross-talk","19876822","no","no","","","","","","","","","","","","","The full text was not read because progesterone was only briefly mentioned as being involved in pregnancy, and Notch was mentioned in a different context",""
+"Progesterone-mediated oocyte maturation","Notch signaling pathway","Notch Progesterone Cross-talk","19876822","no","no","","","","","","","","","","","","","The full text was not read because progesterone was only briefly mentioned as being involved in pregnancy, and Notch was mentioned in a different context",""
+"Notch signaling pathway","Progesterone-mediated oocyte maturation","Notch Progesterone Pathway","25701842","no","no","","","","","","","","","","","","","The full article was not read because the abstract mainly discusses Notch regulating progesterone secretion from luteal cells, but does not mention interacting with progesterone itself",""
+"Progesterone-mediated oocyte maturation","Notch signaling pathway","Notch Progesterone Pathway","25701842","no","no","","","","","","","","","","","","","The full article was not read because the abstract mainly discusses Notch regulating progesterone secretion from luteal cells, but does not mention interacting with progesterone itself",""
+"Notch signaling pathway","Progesterone-mediated oocyte maturation","Notch Progesterone Pathway","25433026","no","no","","","","","","","","","","","","","The article suggests that there is a relationship between Notch and Progesterone, but it mainly talks about Notch affecting the synthesis of progesterone, but not acutally interacting with it directly",""
+"Progesterone-mediated oocyte maturation","Notch signaling pathway","Notch Progesterone Pathway","25433026","yes","no","activating","progesterone","hormone","hormone","Notch1","Q07008","UNIPROT","Rattus norvegicus","uterine endometrium","BTO:0001422","normal/pregnant","hCG and progesterone synergize to activate NOTCH1, which in turn induces alpha smooth muscle actin and inhibits stromal cell apoptosis","In this case the text doesn't seem to suggest that the activation is transcriptional",""
+"Notch signaling pathway","Progesterone-mediated oocyte maturation","Notch Progesterone Pathway","25940784","no","no","","","","","","","","","","","","","The article mainly describes an effect on Notch by Progesterone, not the other way around",""
+"Progesterone-mediated oocyte maturation","Notch signaling pathway","Notch Progesterone Pathway","25940784","yes","no","activating","P4","hormone","hormone","Jag2","Q9QYE5","UNIPROT","Mus musculus","uterus","BTO:0001424","oestrous cycle","Jagged2, signalling through Notch3 and under P4 regulation, is controlling the ratio of secretory to ciliated cells and/or the secretory activity of the former cells in the ampulla","The article isn't completely clear about the relationship, but it does seem that there is a direct effect on Notch by Progesterone",""
+"Notch signaling pathway","Progesterone-mediated oocyte maturation","Notch Progesterone Pathway","24992499","no","no","","","","","","","","","","","","","The full article was not read because the abstract mainly describes reactions to zinc, not to each other",""
+"Progesterone-mediated oocyte maturation","Notch signaling pathway","Notch Progesterone Pathway","24992499","no","no","","","","","","","","","","","","","The full article was not read because the abstract mainly describes reactions to zinc, not to each other",""
+"Notch signaling pathway","Progesterone-mediated oocyte maturation","Notch Progesterone Pathway","24476135","no","no","","","","","","","","","","","","","The text states that KLF9 (a progesterone receptor) regulates notch, but it also states that whether it is direct or indirect needs more study, so there is not enough evidence to say that they interact",""
+"Progesterone-mediated oocyte maturation","Notch signaling pathway","Notch Progesterone Pathway","24476135","no","no","","","","","","","","","","","","","The text states that KLF9 (a progesterone receptor coregulator) regulates notch, but it also states that whether it is direct or indirect (acts through ESR and PGR) needs more study, so there is not enough evidence to say that they interact",""
+"Notch signaling pathway","Progesterone-mediated oocyte maturation","Notch Progesterone Pathway","24695060","no","no","","","","","","","","","","","","","The full text was not read because the abstract really only mentioned that Notch was active in the ovaries, and didn't suggest that they interact at all",""
+"Progesterone-mediated oocyte maturation","Notch signaling pathway","Notch Progesterone Pathway","24695060","no","no","","","","","","","","","","","","","The full text was not read because the abstract really only mentioned that Notch was active in the ovaries, and didn't suggest that they interact at all",""
+"Notch signaling pathway","Progesterone-mediated oocyte maturation","Notch Progesterone Pathway","23128334","no","no","","","","","","","","","","","","","The full article was not read because the abstract only talks about medroxyprogesterone acetate as a cancer treatment but it doesn't suggest that it has any direct effect on notch",""
+"Progesterone-mediated oocyte maturation","Notch signaling pathway","Notch Progesterone Pathway","23128334","no","no","","","","","","","","","","","","","The full article was not read because the abstract only talks about medroxyprogesterone acetate as a cancer treatment but it doesn't suggest that it has any direct effect on notch",""
+"Notch signaling pathway","Progesterone-mediated oocyte maturation","Notch Progesterone Pathway","23621987","no","no","","","","","","","","","","","","","The full text was not read because the abstract barely mentions progesterone and mainly talks about the interactions between Notch and Wnt",""
+"Progesterone-mediated oocyte maturation","Notch signaling pathway","Notch Progesterone Pathway","23621987","no","no","","","","","","","","","","","","","The full text was not read because the abstract barely mentions progesterone and mainly talks about the interactions between Notch and Wnt",""
+"Notch signaling pathway","Progesterone-mediated oocyte maturation","Notch Progesterone Pathway","25789008","no","no","","","","","","","","","","","","","The full article was not read because the abstract mainly talked about the correlation between progesterone and estrogen, and Notch and beta-catenin, but it did not mention that they have any correlation with each other",""
+"Progesterone-mediated oocyte maturation","Notch signaling pathway","Notch Progesterone Pathway","25789008","no","no","","","","","","","","","","","","","The full article was not read because the abstract mainly talked about the correlation between progesterone and estrogen, and Notch and beta-catenin, but it did not mention that they have any correlation with each other",""
+"Notch signaling pathway","Progesterone-mediated oocyte maturation","Notch Progesterone Pathway","23699387","no","no","","","","","","","","","","","","","The full text was not read because progesterone was only mentioned once in the abstract and it did not say anything about interacting with notch",""
+"Progesterone-mediated oocyte maturation","Notch signaling pathway","Notch Progesterone Pathway","23699387","no","no","","","","","","","","","","","","","The full text was not read because progesterone was only mentioned once in the abstract and it did not say anything about interacting with notch",""
+"Notch signaling pathway","Thyroid hormone synthesis","Notch TSH Pathway","23008514","no","no","","","","","","","","","","","","","The abstract suggested that TSH has some effect on Notch, but the article only discusses Notch being involved in thyroid development",""
+"Thyroid hormone synthesis","Notch signaling pathway","Notch TSH Pathway","23008514","no","no","","","","","","","","","","","","","The abstract suggested that TSH has some effect on Notch, but the article only discusses Notch being involved in thyroid development",""
+"Notch signaling pathway","Thyroid hormone synthesis","Notch TSH Pathway","18664540","no","no","","","","","","","","","","","","","It seems that Notch plays an important role in thyroid differentiation, but it mentions no direct effect on TSH by Notch",""
+"Thyroid hormone synthesis","Notch signaling pathway","Notch TSH Pathway","18664540","yes","yes","activating","CGA","P01215","UNIPROT","","","","Homo sapiens","thyroid gland","BTO:0001379","tumors","We found that components of this pathway are expressed in normal thyroid cells and that their expression is up-regulated by TSH","The article isn't very clear about the exact relationship that TSH and Notch have, but it seems that TSH transcriptionally regulates Notch",""
+"Notch signaling pathway","Thyroid hormone synthesis","Notch TSH Pathway","10704395","no","no","","","","","","","","","","","","","The full article was not read because the abstract discusses tsh as the gene teashirt, not thyroid stimulating hormone",""
+"Thyroid hormone synthesis","Notch signaling pathway","Notch TSH Pathway","10704395","no","no","","","","","","","","","","","","","The full article was not read because the abstract discusses tsh as the gene teashirt, not thyroid stimulating hormone",""
+"Notch signaling pathway","Thyroid hormone synthesis","Notch TG Crosstalk","25585350","no","no","","","","","","","","","","","","","The full text was not read because the TG referred to in the abstract meant transgene",""
+"Thyroid hormone synthesis","Notch signaling pathway","Notch TG Crosstalk","25585350","no","no","","","","","","","","","","","","","The full text was not read because the TG referred to in the abstract meant transgene",""
+"Notch signaling pathway","Thyroid hormone synthesis","Notch TG Pathway","24445048","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not mention anything about thyroid, it only talked about the effect of a high fat diet on the Notch pathway in maternal mice and offspring",""
+"Thyroid hormone synthesis","Notch signaling pathway","Notch TG Pathway","24445048","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not mention anything about thyroid, it only talked about the effect of a high fat diet on the Notch pathway in maternal mice and offspring",""
+"Notch signaling pathway","Thyroid hormone synthesis","Notch TG Pathway","20706108","no","no","","","","","","","","","","","","","The full article was not read because the TG in the abstract was for transgenic, not about thyroid",""
+"Thyroid hormone synthesis","Notch signaling pathway","Notch TG Pathway","20706108","no","no","","","","","","","","","","","","","The full article was not read because the TG in the abstract was for transgenic, not about thyroid",""
+"Notch signaling pathway","Thyroid hormone synthesis","Notch TG Pathway","21737799","no","no","","","","","","","","","","","","","The full article was not read because the TG in the abstract was for transgenic, not about thyroid",""
+"Thyroid hormone synthesis","Notch signaling pathway","Notch TG Pathway","21737799","no","no","","","","","","","","","","","","","The full article was not read because the TG in the abstract was for transgenic, not about thyroid",""
+"Notch signaling pathway","Thyroid hormone synthesis","Notch TG Pathway","12842085","no","no","","","","","","","","","","","","","The full text was not read because the abstract discusses TGF-alpha, not TG",""
+"Thyroid hormone synthesis","Notch signaling pathway","Notch TG Pathway","12842085","no","no","","","","","","","","","","","","","The full text was not read because the abstract discusses TGF-alpha, not TG",""
+"Notch signaling pathway","Thyroid hormone synthesis","Notch TG Pathway","21872584","no","no","","","","","","","","","","","","","The full article was not read because the TG in the abstract was for transgenic, not about thyroid",""
+"Thyroid hormone synthesis","Notch signaling pathway","Notch TG Pathway","21872584","no","no","","","","","","","","","","","","","The full article was not read because the TG in the abstract was for transgenic, not about thyroid",""
+"Notch signaling pathway","Thyroid hormone synthesis","Notch TG Pathway","17046738","no","no","","","","","","","","","","","","","The full article was not read because the TG in the abstract was for transgenic, not about thyroid",""
+"Thyroid hormone synthesis","Notch signaling pathway","Notch TG Pathway","17046738","no","no","","","","","","","","","","","","","The full article was not read because the TG in the abstract was for transgenic, not about thyroid",""
+"Notch signaling pathway","Thyroid hormone synthesis","Notch TG Pathway","18193087","no","no","","","","","","","","","","","","","The full article was not read because the TG in the abstract was for transgenic, not about thyroid",""
+"Thyroid hormone synthesis","Notch signaling pathway","Notch TG Pathway","18193087","no","no","","","","","","","","","","","","","The full article was not read because the TG in the abstract was for transgenic, not about thyroid",""
+"Notch signaling pathway","Thyroid hormone synthesis","Notch TTF1 Pathway","24509876","no","no","","","","","","","","","","","","","The full text was not read because the abstract didn't really discuss any interaction between Notch and TTF1, and it didn't really mention anything about thyroid",""
+"Thyroid hormone synthesis","Notch signaling pathway","Notch TTF1 Pathway","24509876","no","no","","","","","","","","","","","","","The full text was not read because the abstract didn't really discuss any interaction between Notch and TTF1, and it didn't really mention anything about thyroid",""
+"Notch signaling pathway","Thyroid hormone synthesis","Notch TTF1 Pathway","23594881","no","no","","","","","","","","","","","","","The text suggests that there may be some kind of relationship between the two, but it is much too ambiguous and does not give anything concrete",""
+"Thyroid hormone synthesis","Notch signaling pathway","Notch TTF1 Pathway","23594881","no","no","","","","","","","","","","","","","The text suggests that there may be some kind of relationship between the two, but it is much too ambiguous and does not give anything concrete",""
+"Notch signaling pathway","Thyroid hormone synthesis","Notch TTF1 Pathway","24419754","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned  TTF1 to say that it is affected by a drug that treats thyroid cancer",""
+"Thyroid hormone synthesis","Notch signaling pathway","Notch TTF1 Pathway","24419754","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned  TTF1 to say that it is affected by a drug that treats thyroid cancer",""
+"Notch signaling pathway","mTOR signaling pathway","Notch mTOR Crosstalk","24556838","yes","yes","activating","","","","Rptor","D3ZDU2","UNIPROT","Rattus norvegicus","liver","BTO:0000759","lipogenesis","Hyperactivation of Notch signalling increases RAPTOR protein expression","The text does not go into very much detail about the interactions between Notch and mTOR, but there does appear to be some transcriptional and direct interactions",""
+"Notch signaling pathway","mTOR signaling pathway","Notch mTOR Crosstalk","24556838","yes","no","activating","","","","Rptor/Mtor","D3ZDU2/P42346","UNIPROT","Rattus norvegicus","liver","BTO:0000759","lipogenesis","Hyperactivation of Notch signalling also promotes mTOR–RAPTOR interactions","The text does not go into very much detail about the interactions between Notch and mTOR, but there does appear to be some transcriptional and direct interactions",""
+"mTOR signaling pathway","Notch signaling pathway","Notch mTOR Crosstalk","24556838","no","no","","","","","","","","","","","","","There only seemed to be an effect on mTOR by Notch",""
+"Notch signaling pathway","mTOR signaling pathway","Notch mTOR Crosstalk","23482748","no","no","","","","","","","","","","","","","The text claims that there is crosstalk, but only seems to describe indirect relationships between mTOR and Notch. The full text was not available through PubMed but was available through the library and has been saved",""
+"mTOR signaling pathway","Notch signaling pathway","Notch mTOR Crosstalk","23482748","no","no","","","","","","","","","","","","","The text claims that there is crosstalk, but only seems to describe indirect relationships between mTOR and Notch. The full text was not available through PubMed but was available through the library and has been saved",""
+"Notch signaling pathway","mTOR signaling pathway","Notch mTOR Crosstalk","23104651","no","no","","","","","","","","","","","","","The text mentions multiple times that the pathways crosstalk, but the only example given is from mTOR to Notch",""
+"mTOR signaling pathway","Notch signaling pathway","Notch mTOR Crosstalk","23104651","yes","no","inhibiting","","","","","","","Homo sapiens","breast","BTO:0000149","cancer","mTOR signaling has been reported to crosstalk with the Notch signaling pathway in several malignant cells","The article goes on to talk about mTOR inhibitors reversing the Notch pathway, and this is in the context of the crosstalk between them, so it is most likely direct, although it does not provide much other evidence",""
+"Notch signaling pathway","Adipocytokine signaling pathway","Notch Adipocytokine Crosstalk","23104651","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed crosstalk between each pathway and mTOR",""
+"Adipocytokine signaling pathway","Notch signaling pathway","Notch Adipocytokine Crosstalk","23104651","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed crosstalk between each pathway and mTOR",""
+"Notch signaling pathway","Adipocytokine signaling pathway","Notch Adipocytokine Pathway","21803433","no","no","","","","","","","","","","","","","The text only briefly mentioned adipocytokine and it was just in a list of other pathways that are regulated by cytokines, and notch was mostly discussed in relation to Wnt",""
+"Adipocytokine signaling pathway","Notch signaling pathway","Notch Adipocytokine Pathway","21803433","no","no","","","","","","","","","","","","","The text only briefly mentioned adipocytokine and it was just in a list of other pathways that are regulated by cytokines, and notch was mostly discussed in relation to Wnt",""
+"Notch signaling pathway","Adipocytokine signaling pathway","Notch Leptin Crosstalk","23562747","no","no","","","","","","","","","","","","","There only seemed to be an effect on notch by leptin",""
+"Adipocytokine signaling pathway","Notch signaling pathway","Notch Leptin Crosstalk","23562747","yes","no","activating","LEP","P41159","UNIPROT","NOTCH1,NOTCH2,NOTCH3,NOTCH4","P46531,Q04721,Q9UM47,Q99466","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Leptin was identified as an inducer of Notch (ligands JAG1 and Dll-4; receptors Notch1–4 and targeted molecules, survivin and Hey2) in breast cancer","The text explains that leptin activates the notch pathway at many points and there is no suggestion that it is transcriptional",""
+"Notch signaling pathway","Adipocytokine signaling pathway","Notch Leptin Crosstalk","21731759","no","no","","","","","","","","","","","","","There only seemed to be an effect on notch by leptin",""
+"Adipocytokine signaling pathway","Notch signaling pathway","Notch Leptin Crosstalk","21731759","yes","no","activating","LEP","P41159","UNIPROT","NOTCH1,NOTCH2,NOTCH3","P46531,Q04721,Q9UM47","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Leptin signaling upregulates the activity of CSL-promoter and Notch mRNA expression as well as Notch activation","Since the article says that leptin upregulates the activity of the CSL promoter, there seems to be direct crosstalk, which then affects the transcription of notch genes, and it also says that leptin activates notch directly",""
+"Adipocytokine signaling pathway","Notch signaling pathway","Notch Leptin Crosstalk","21731759","yes","yes","activating","LEP","P41159","UNIPROT","NOTCH1,NOTCH2,NOTCH3","P46531,Q04721,Q9UM47","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Remarkably, leptin upregulates Notch at transcriptional/translational levels","The text states that leptin upregulates Notch at a transcriptional level",""
+"Notch signaling pathway","Adipocytokine signaling pathway","Notch Leptin Crosstalk","24716804","no","no","","","","","","","","","","","","","There only seemed to be an effect on notch by leptin",""
+"Adipocytokine signaling pathway","Notch signaling pathway","Notch Leptin Crosstalk","24716804","yes","no","activating","LEP","P41159","UNIPROT","","","","Homo sapiens","breast","BTO:0000149","cancer","Leptin increased the expression and activation of several members of the Notch family of proteins in breast cancer cells and derived tumors","The text states that leptin increased the activation of several components of the Notch pathway",""
+"Adipocytokine signaling pathway","Notch signaling pathway","Notch Leptin Crosstalk","24716804","yes","yes","activating","LEP","P41159","UNIPROT","","","","Homo sapiens","breast","BTO:0000149","cancer","Leptin increased the expression and activation of several members of the Notch family of proteins in breast cancer cells and derived tumors","The text states that leptin upregulates Notch at a transcriptional level",""
+"Notch signaling pathway","Adipocytokine signaling pathway","Notch Leptin Crosstalk","24202338","no","no","","","","","","","","","","","","","There only seemed to be an effect on notch by leptin",""
+"Adipocytokine signaling pathway","Notch signaling pathway","Notch Leptin Crosstalk","24202338","yes","no","activating","LEP","P41159","UNIPROT","NOTCH1,NOTCH2,NOTCH3,NOTCH4","P46531,Q04721,Q9UM47,Q99466","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Remarkably, in breast cancer leptin upregulated Notch1-4/JAG1/Dll-4, Notch target genes: Hey2 and survivin","The text states that leptin increased the activation of several components of the Notch pathway",""
+"Adipocytokine signaling pathway","Notch signaling pathway","Notch Leptin Crosstalk","24202338","yes","yes","activating","LEP","P41159","UNIPROT","NOTCH4","Q99466","UNIPROT","Homo sapiens","blood vessel endothelium","BTO:0000766","normal","Leptin was found to regulate the expression of Notch4 receptor and its ligand, JAG1 in human endothelial and blood CD34+ cells","The text states that leptin upregulates Notch at a transcriptional level",""
+"Notch signaling pathway","Adipocytokine signaling pathway","Notch Leptin Crosstalk","21193018","no","no","","","","","","","","","","","","","There only seemed to be an effect on notch by leptin",""
+"Adipocytokine signaling pathway","Notch signaling pathway","Notch Leptin Crosstalk","21193018","yes","no","activating","LEP","P41159","UNIPROT","NOTCH1","P46531","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","We recently observed that leptin was able to activate Notch signaling pathway (Notch1,3,4 NICD and CSL) in mouse (4T1, EMT6 and MMT) and human breast cancer cell lines (MCF-7 and MDA-MB-231) under normoxic conditions","The text states that leptin increased the activation of several components of the Notch pathway",""
+"Adipocytokine signaling pathway","Notch signaling pathway","Notch Leptin Crosstalk","21193018","yes","yes","activating","LEP","P41159","UNIPROT","NOTCH1,NOTCH3,NOTCH4","P46531,Q9UM47,Q99466","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Moreover, leptin increased the expression of both Notch receptors and ligands.","The text states that leptin upregulates Notch at a transcriptional level",""
+"Notch signaling pathway","ErbB signaling pathway","Notch ErbB Cross-talk","23542173","no","no","","","","","","","","","","","","","The text says that the main crosstalk between Notch and EGFR/HER2 is at the mediator level. It says that the the notch acts via ERK and AKT activation",""
+"ErbB signaling pathway","Notch signaling pathway","Notch ErbB Cross-talk","23542173","yes","yes","inhibiting","EGFR","P00533","UNIPROT","NOTCH1","P46531","UNIPROT","Homo sapiens","many","","cancer","Interestingly, EGFR signaling inhibits Notch1 gene transcription","The text does not go into very much detail about the relationship between these pathways but it does state that EGFR inhibits the transcription of Notch1",""
+"ErbB signaling pathway","Notch signaling pathway","Notch ErbB Cross-talk","23542173","yes","no","inhibiting","ERBB2","P04626","UNIPROT","NOTCH1","P46531","UNIPROT","Homo sapiens","many","","cancer","HER2 inhibition activates Notch1","The text doesn't go into much detail but it seems that the inhibition of HER2 activates Notch1, and it does not suggest that it is transcriptional instead of direct",""
+"Notch signaling pathway","ErbB signaling pathway","Notch ErbB Cross-talk","23457626","no","no","","","","","","","","","","","","","The text kept stating that the data suggested crosstalk, but the article didn't really provide any support or evidence, it only explained that that using inhibitors of both pathways produces an additive effect in the conducted experiment",""
+"ErbB signaling pathway","Notch signaling pathway","Notch ErbB Cross-talk","23457626","no","no","","","","","","","","","","","","","The text kept stating that the data suggested crosstalk, but the article didn't really provide any support or evidence, it only explained that that using inhibitors of both pathways produces an additive effect in the conducted experiment",""
+"Notch signaling pathway","ErbB signaling pathway","Notch ErbB Cross-talk","25599599","no","no","","","","","","","","","","","","","The text states that the crosstalk between the pathways is mediated by PI3K/Ak",""
+"ErbB signaling pathway","Notch signaling pathway","Notch ErbB Cross-talk","25599599","no","no","","","","","","","","","","","","","The text states that the crosstalk between the pathways is mediated by PI3K/Ak",""
+"Notch signaling pathway","ErbB signaling pathway","Notch ErbB Cross-talk","19344631","no","no","","","","","","","","","","","","","There doesn't seem to be any effect on ErbB by Notch",""
+"ErbB signaling pathway","Notch signaling pathway","Notch ErbB Cross-talk","19344631","yes","no","inhibiting","ERBB2","P04626","UNIPROT","","","","Homo sapiens","breast","BTO:0000149","cancer","The overexpression of ErbB-2 led to decreased Notch signaling with decreased expression of canonical Notch target genes despite the fact that levels of Notch-1 receptor appeared unchanged","The sentence is in the context of crosstalk between ErbB and Notch, and since there was less expression of Notch target genes but there was plenty of ligand and receptor, that means that ErbB must have interfered at some point in the pathway, and not transcriptionally",""
+"Notch signaling pathway","ErbB signaling pathway","Notch ErbB Cross-talk","20024517","yes","yes","activating","RBPJ","Q06330","UNIPROT","ERBB2","P04626","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Moreover, it has been reported that the ErbB-2 promoter is positively regulated by RBPJkappa (CSL) and Notch-1","Since it says that CSL and Notch1 regulate the ErbB-2 promoter, that most likely means there is some transcriptional regulation",""
+"ErbB signaling pathway","Notch signaling pathway","Notch ErbB Cross-talk","20024517","yes","no","inhibiting","ERBB2","P04626","UNIPROT","NOTCH1","P46531","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Osipo et al. showed that overexpression of ErbB-2 in breast cancer cells (BT474, SKBR3, and MCF-7/HER2) decreased Notch-1 transcriptional activity, whereas inhibition of ErbB-2 by trastuzumab or a dual EGFR/ErbB-2 tyrosine kinase inhibitor similar to lapatinib increased Notch-1 transcriptional activity","There is a clear inhibitory effect on Notch by ErbB and it does not seem to be transcriptional",""
+"Notch signaling pathway","Estrogen signaling pathway","Notch Estrogen Crosstalk","23917222","no","no","","","","","","","","","","","","","The full text was not read because the abstract mainly discusses the relationship between Notch and PKCalpha, and says that Notch works independently of ER",""
+"Estrogen signaling pathway","Notch signaling pathway","Notch Estrogen Crosstalk","23917222","no","no","","","","","","","","","","","","","The full text was not read because the abstract mainly discusses the relationship between Notch and PKCalpha, and says that Notch works independently of ER",""
+"Notch signaling pathway","Estrogen signaling pathway","Notch Estrogen Crosstalk","24275097","no","no","","","","","","","","","","","","","There only seemed to be an effect on Notch by Estrogen",""
+"Estrogen signaling pathway","Notch signaling pathway","Notch Estrogen Crosstalk","24275097","yes","yes","activating","GPER1","Q99527","UNIPROT","NOTCH1","P46531","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","The mechanism through which GPER leads to Notch-1 activation seems to be transcriptional, as an increase of Notch-1 mRNA levels was found in response to E2 and G-1","The article seems to explain that ER activates the transcription of Hes1, but then it goes on to explain that this is caused by the increased expression of notch1",""
+"Notch signaling pathway","Estrogen signaling pathway","Notch Estrogen Crosstalk","21193018","no","no","","","","","","","","","","","","","There only seemed to be an effect on Notch by Estrogen",""
+"Estrogen signaling pathway","Notch signaling pathway","Notch Estrogen Crosstalk","21193018","yes","yes","activating","ESR1","P03372","UNIPROT","NOTCH1","P46531","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","breast cancer cell line","E2 promoted 8-fold and 6-fold increase in Notch1 and JAG1 expression, respectively, in breast cancer MCF-7 cells","Since the text states that E2 increases the expression of Notch1 and Jag1, the crosstalk seems to be transcriptional",""
+"Notch signaling pathway","Estrogen signaling pathway","Notch Estrogen Cross-talk","18593923","no","no","","","","","","","","","","","","","There only seemed to be an effect on Notch by Estrogen",""
+"Estrogen signaling pathway","Notch signaling pathway","Notch Estrogen Cross-talk","18593923","yes","no","inhibiting","estrogen","hormone","hormone","","","","Homo sapiens","breast","BTO:0000149","cancer","Our data suggest that estrogen inhibits Notch signaling through an ERa-dependent effect","The article also suggests that the inhibition is in part mediated by the inhibition of Notch cleavage by gamma-secretase, but that means that there was at least some direct interaction",""
+"Notch signaling pathway","Estrogen signaling pathway","Notch Estrogen Cross-talk","19344631","no","no","","","","","","","","","","","","","There only seemed to be an effect on Notch by Estrogen",""
+"Estrogen signaling pathway","Notch signaling pathway","Notch Estrogen Cross-talk","19344631","yes","no","inhibiting","17beta-estradiol","Other","Other","NOTCH1","P46531","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","We determined that in 17β-estradiol-treated cells, Notch-1 is primarily distributed to the cell membrane but it is not efficiently activated by Notch ligands","The effect on Notch by estradiol is in the context of talking about crosstalk between and ER and Notch. The article suggests that estradiol has some sort effect on Notch-1 so that it can effectively be activated by ligands",""
+"Notch signaling pathway","GnRH signaling pathway","Notch GnRH Pathway","23922013","no","no","","","","","","","","","","","","","The full text was not read because GnRH was only mentioned as an ovarian stimulator, and didn't really have anything to do with the study being talked about",""
+"GnRH signaling pathway","Notch signaling pathway","Notch GnRH Pathway","23922013","no","no","","","","","","","","","","","","","The full text was not read because GnRH was only mentioned as an ovarian stimulator, and didn't really have anything to do with the study being talked about",""
+"Notch signaling pathway","GnRH signaling pathway","Notch GnRH Pathway","24013142","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention Notch",""
+"GnRH signaling pathway","Notch signaling pathway","Notch GnRH Pathway","24013142","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention Notch",""
+"Notch signaling pathway","GnRH signaling pathway","Notch GnRH Pathway","811331","no","no","","","","","","","","","","","","","The full article was not read because GnRH was not mentioned in the abstract and the notch that was mentioned was a different notch",""
+"GnRH signaling pathway","Notch signaling pathway","Notch GnRH Pathway","811331","no","no","","","","","","","","","","","","","The full article was not read because GnRH was not mentioned in the abstract and the notch that was mentioned was a different notch",""
+"Notch signaling pathway","GnRH signaling pathway","Notch GnRH Pathway","20022929","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only talked about how GnRH antagonist suppressed testosterone production, and how Notch signaling is affected by testosterone",""
+"GnRH signaling pathway","Notch signaling pathway","Notch GnRH Pathway","20022929","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only talked about how GnRH antagonist suppressed testosterone production, and how Notch signaling is affected by testosterone",""
+"Notch signaling pathway","GnRH signaling pathway","Notch GnRH Pathway","25555499","no","no","","","","","","","","","","","","","Both pathways were only mentioned in a list of many pathways that are involved in cardiovascular disease and preeclampsia",""
+"GnRH signaling pathway","Notch signaling pathway","Notch GnRH Pathway","25555499","no","no","","","","","","","","","","","","","Both pathways were only mentioned in a list of many pathways that are involved in cardiovascular disease and preeclampsia",""
+"Notch signaling pathway","HIF-1 signaling pathway","Notch HIF-1 Crosstalk","25108166","yes","yes","inhibiting","NOTCH1","P46531","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","neuron","BTO:0000938","oxidative stress","In summary, these experimental observations indicate that inhibition of Notch1 signaling up-regulates HIF-1/Foxo3a signaling in oxidative stress conditions","The article states that there is bidirectional crosstalk and clearly states the effect each one has on the other. There is also some suggestion of transcriptional crosstalk in the paper, but it explains that those need more study to determine the mechanisms",""
+"HIF-1 signaling pathway","Notch signaling pathway","Notch HIF-1 Crosstalk","25108166","yes","no","activating","HIF1A","Q16665","UNIPROT","NOTCH1","P46531","UNIPROT","Homo sapiens","neuron","BTO:0000938","oxidative stress","HIF-1α could activate Notch signaling through interaction with NICD and induce Notch-mediated down-stream responses","The article states that there is bidirectional crosstalk and clearly states the effect each one has on the other. There is also some suggestion of transcriptional crosstalk in the paper, but it explains that those need more study to determine the mechanisms",""
+"Notch signaling pathway","Hippo signaling pathway","Notch Hippo Crosstalk","25907767","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed each pathway interacting with EGFR and did not give any suggestion that they crosstalk with each other",""
+"Hippo signaling pathway","Notch signaling pathway","Notch Hippo Crosstalk","25907767","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed each pathway interacting with EGFR and did not give any suggestion that they crosstalk with each other",""
+"Notch signaling pathway","Hippo signaling pathway","Notch Hippo Crosstalk","23312716","no","no","","","","","","","","","","","","","The text mainly discussed the crosstalk between Hippo and Wnt, and hardly mentioned notch",""
+"Hippo signaling pathway","Notch signaling pathway","Notch Hippo Crosstalk","23312716","no","no","","","","","","","","","","","","","The text mainly discussed the crosstalk between Hippo and Wnt, and hardly mentioned notch",""
+"Notch signaling pathway","Hippo signaling pathway","Notch Hippo Crosstalk","22492181","no","no","","","","","","","","","","","","","The abstract suggests crosstalk, but the text mainly discusses crosstalk between each pathway and Wnt. There seems to be some relationship between Hippo and Notch, but it is not explained clearly and is too ambiguous. The full text was not available through PubMed but has been saved",""
+"Hippo signaling pathway","Notch signaling pathway","Notch Hippo Crosstalk","22492181","no","no","","","","","","","","","","","","","The abstract suggests crosstalk, but the text mainly discusses crosstalk between each pathway and Wnt. There seems to be some relationship between Hippo and Notch, but it is not explained clearly and is too ambiguous. The full text was not available through PubMed but has been saved",""
+"Notch signaling pathway","Hippo signaling pathway","Notch Hippo Crosstalk","24556838","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses how each pathway interacts with mTOR, not with each other",""
+"Hippo signaling pathway","Notch signaling pathway","Notch Hippo Crosstalk","24556838","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses how each pathway interacts with mTOR, not with each other",""
+"Notch signaling pathway","Hippo signaling pathway","Notch Hippo Crosstalk","23287077","no","no","","","","","","","","","","","","","There only seems to be an effect on Notch by Hippo",""
+"Hippo signaling pathway","Notch signaling pathway","Notch Hippo Crosstalk","23287077","yes","no","inhibiting","Yap1","P46938","UNIPROT","","","","Mus musculus","intestine","BTO:0000648","dysplasia","In a transgenic mouse model, YAP overexpression causes intestinal dysplasia through activation of Notch signaling","There was not much detail or information about this relationship, but it seems like YAP has some kind of direct effect on Notch",""
+"Notch signaling pathway","Insulin signaling pathway","Notch Insulin Crosstalk","26106366","yes","no","activating","NOTCH1","P46531","UNIPROT","IGF1R","P08069","UNIPROT","Homo sapiens","T-lymphocyte","BTO:0000782","leukemia/adenocarcinoma","Previous studies have demonstrated that the IGF-1R is a substrate of, and upregulated by, Notch1 signaling in T-ALL cells and in lung adenocarcinomas","The text doesn't provide very much detail but it does seem clear that there is some direct effect on IGF-1R by Notch",""
+"Notch signaling pathway","Insulin signaling pathway","Notch Insulin Crosstalk","26106366","yes","no","activating","NOTCH1","P46531","UNIPROT","IGF1R","P08069","UNIPROT","Homo sapiens","lung","BTO:0000763","leukemia/adenocarcinoma","Previous studies have demonstrated that the IGF-1R is a substrate of, and upregulated by, Notch1 signaling in T-ALL cells and in lung adenocarcinomas","The text doesn't provide very much detail but it does seem clear that there is some direct effect on IGF-1R by Notch",""
+"Insulin signaling pathway","Notch signaling pathway","Notch Insulin Crosstalk","26106366","no","no","","","","","","","","","","","","","The text states that there have been no studies that show that IGF-1R regulates Notch",""
+"Notch signaling pathway","Insulin signaling pathway","Notch Insulin Crosstalk","22916028","no","no","","","","","","","","","","","","","The full text was not read because the abstract mainly discusses the crosstalk between Insulin and MAPK, and hardly mentions Notch",""
+"Insulin signaling pathway","Notch signaling pathway","Notch Insulin Crosstalk","22916028","no","no","","","","","","","","","","","","","The full text was not read because the abstract mainly discusses the crosstalk between Insulin and MAPK, and hardly mentions Notch",""
+"Notch signaling pathway","Insulin signaling pathway","Notch Insulin Crosstalk","24993942","no","no","","","","","","","","","","","","","The text didn't really discuss any interaction that Notch might have with Insulin/FOXO, it mainly talked about Notch interacting with Cut, a homeobox transcription factor",""
+"Insulin signaling pathway","Notch signaling pathway","Notch Insulin Crosstalk","24993942","no","no","","","","","","","","","","","","","The text didn't really discuss any interaction that Notch might have with Insulin/FOXO, it mainly talked about Notch interacting with Cut, a homeobox transcription factor",""
+"Notch signaling pathway","Insulin signaling pathway","Notch Insulin Cross-talk","25035811","no","no","","","","","","","","","","","","","The text mainly talked about each pathway's interaction with HIF-1, and didn't say that they interact with each other",""
+"Insulin signaling pathway","Notch signaling pathway","Notch Insulin Cross-talk","25035811","no","no","","","","","","","","","","","","","The text mainly talked about each pathway's interaction with HIF-1, and didn't say that they interact with each other",""
+"Notch signaling pathway","Insulin signaling pathway","Notch Insulin Cross-talk","23806629","no","no","","","","","","","","","","","","","The full text was not read because Insulin is not mentioned in the abstract, only Notch",""
+"Insulin signaling pathway","Notch signaling pathway","Notch Insulin Cross-talk","23806629","no","no","","","","","","","","","","","","","The full text was not read because Insulin is not mentioned in the abstract, only Notch",""
+"Notch signaling pathway","Jak-STAT signaling pathway","Notch Jak-STAT Crosstalk","15156153","yes","yes","activating","[HES1/HES5]","[Q14469/Q5TA89]","UNIPROT","STAT3","P40763","UNIPROT","Homo sapiens","glial cell","BTO:0002606","development","We found that these Hes proteins bind to STAT3 directly, thereby inducing phosphorylation and activation by recruitment of JAK2","The text does state that there is crosstalk and that Hes binds directly to STAT3, but since Hes is a target gene of Notch, it is unclear if Hes is considered part of the Notch pathway or not",""
+"Jak-STAT signaling pathway","Notch signaling pathway","Notch Jak-STAT Crosstalk","15156153","yes","no","activating","STAT3","P40763","UNIPROT","","","","Homo sapiens","glial cell","BTO:0002606","development","These results suggest that STAT3 is an essential effector of the Notch–Hes signalling in glial differentiation","The sentence recorded is really the only evidence provided for crosstalk from Jak-STAT to Notch, but based on the sentence it sounds like STAT3 has some direct effect on the pathway",""
+"Notch signaling pathway","Jak-STAT signaling pathway","Notch Jak-STAT Crosstalk","22492181","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned crosstalk between each pathway and Hippo",""
+"Jak-STAT signaling pathway","Notch signaling pathway","Notch Jak-STAT Crosstalk","22492181","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned crosstalk between each pathway and Hippo",""
+"Notch signaling pathway","Jak-STAT signaling pathway","Notch Jak-STAT Cross-talk","19171888","no","no","","","","","","","","","","","","","The abstract suggested that there may be some interaction between the two pathways, but Jak-STAT was not mentioned anywhere else in the text",""
+"Jak-STAT signaling pathway","Notch signaling pathway","Notch Jak-STAT Cross-talk","19171888","no","no","","","","","","","","","","","","","The abstract suggested that there may be some interaction between the two pathways, but Jak-STAT was not mentioned anywhere else in the text",""
+"Notch signaling pathway","Jak-STAT signaling pathway","Notch Jak-STAT Pathway","24069565","no","no","","","","","","","","","","","","","The full article was not read because Notch was not mentioned in the abstract",""
+"Jak-STAT signaling pathway","Notch signaling pathway","Notch Jak-STAT Pathway","24069565","no","no","","","","","","","","","","","","","The full article was not read because Notch was not mentioned in the abstract",""
+"Notch signaling pathway","Jak-STAT signaling pathway","Notch Jak-STAT Pathway","25146167","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only discusses how each pathway interacts with PI3K/Akt/mTOR",""
+"Jak-STAT signaling pathway","Notch signaling pathway","Notch Jak-STAT Pathway","25146167","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only discusses how each pathway interacts with PI3K/Akt/mTOR",""
+"Notch signaling pathway","MAPK signaling pathway","Notch MAPK Crosstalk","24424521","yes","no","inhibiting","NOTCH1","P46531","UNIPROT","[MAPK11/MAPK14/MAPK12]","[Q15759/Q16539/P53778]","UNIPROT","Homo sapiens","epithelial cell","BTO:0000414","immune response","We observed decreased p38 activation upon TNFα stimulation of Notch-1 KD Caco-2 cells","The text does not explain very well how Notch acts on MAPK, but it is said multiple times that MAPK has some kind of reaction based on the actions of Notch",""
+"MAPK signaling pathway","Notch signaling pathway","Notch MAPK Crosstalk","24424521","no","no","","","","","","","","","","","","","There doesn't seem to be an effect on Notch by MAPK",""
+"Notch signaling pathway","MAPK signaling pathway","Notch MAPK Crosstalk","24694299","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned how each pathway interacts with TGF-beta and not each other",""
+"MAPK signaling pathway","Notch signaling pathway","Notch MAPK Crosstalk","24694299","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned how each pathway interacts with TGF-beta and not each other",""
+"Notch signaling pathway","MAPK signaling pathway","Notch MAPK Crosstalk","21731759","no","no","","","","","","","","","","","","","The full text was not read because the abstract only talks about each pathway interacting with leptin, not each other",""
+"MAPK signaling pathway","Notch signaling pathway","Notch MAPK Crosstalk","21731759","no","no","","","","","","","","","","","","","The full text was not read because the abstract only talks about each pathway interacting with leptin, not each other",""
+"Notch signaling pathway","MAPK signaling pathway","Notch MAPK Crosstalk","22916028","no","no","","","","","","","","","","","","","The full text was not read because the abstract mainly discusses the crosstalk between Insulin and MAPK, and hardly mentions Notch",""
+"MAPK signaling pathway","Notch signaling pathway","Notch MAPK Crosstalk","22916028","no","no","","","","","","","","","","","","","The full text was not read because the abstract mainly discusses the crosstalk between Insulin and MAPK, and hardly mentions Notch",""
+"Notch signaling pathway","MAPK signaling pathway","Notch MAPK Crosstalk","16023595","yes","no","inhibiting","","","","","","","Caenorhabditis elegans","female pudendum","BTO:0003101","development","The Notch signaling pathway inhibited the MAPK signaling pathway through the induction of multiple negative regulators of MAPK during C. elegans vulval development","The full was not read because the abstract mainly talks about",""
+"MAPK signaling pathway","Notch signaling pathway","Notch MAPK Crosstalk","16023595","yes","no","inhibiting","","","","Notch","Other","Other","Caenorhabditis elegans","female pudendum","BTO:0003101","development","On the contrary, it was also found that the EGFR-MAPK activation could downregulate Notch via endocytosis during C. elegans vulval development","The article talks a lot about the crosstalk between Notch and MAPK, although it doesn't explain it very well. But it seems like there is some bidirectional crosstalk and there is no suggestion that it is transcriptional",""
+"Notch signaling pathway","Neurotrophin signaling pathway","Notch Neurotrophin Pathway","23027130","no","no","","","","","","","","","","","","","The full text was not read because the abstract does not mention Notch",""
+"Neurotrophin signaling pathway","Notch signaling pathway","Notch Neurotrophin Pathway","23027130","no","no","","","","","","","","","","","","","The full text was not read because the abstract does not mention Notch",""
+"Notch signaling pathway","Neurotrophin signaling pathway","Notch Neurotrophin Pathway","22028443","no","no","","","","","","","","","","","","","The text was very ambiguous about how these two pathways interact. It kept saying that they have some kind of relationship but would not provide any details and said that more research needs to be conducted, so there was not enough evidence to say that there is direct protein-protein interaction",""
+"Neurotrophin signaling pathway","Notch signaling pathway","Notch Neurotrophin Pathway","22028443","yes","yes","activating","Ntrk2","P15209","UNIPROT","","","","Mus musculus","ovary","BTO:0000975","normal","Our results suggest that a mechanism by which activation of TRKB receptors enhances NOTCH signaling in the ovary is by stimulating the synthesis of JAGGED1 in oocytes","The text was very ambiguous about how these two pathways interact. It kept saying that they have some kind of relationship but would not provide any details and said that more research needs to be conducted, so there was not enough evidence to say that there is direct protein-protein interaction. The phrase ""stimulating the synthesis of..."" is unclear in the meaning, so I was not sure whether this was considered crosstalk or not",""
+"Notch signaling pathway","Neurotrophin signaling pathway","Notch Neurotrophin Pathway","18803323","no","no","","","","","","","","","","","","","The full article was not read because both pathways were only mentioned once as having a role in myelination, but there was no suggestion that they interact",""
+"Neurotrophin signaling pathway","Notch signaling pathway","Notch Neurotrophin Pathway","18803323","no","no","","","","","","","","","","","","","The full article was not read because both pathways were only mentioned once as having a role in myelination, but there was no suggestion that they interact",""
+"Notch signaling pathway","Neurotrophin signaling pathway","Notch NGF Pathway","25817714","no","no","","","","","","","","","","","","","The full text was not read because the abstract only talks about both pathway having some kind of effect on Muller cells, and does not suggest that they interact",""
+"Neurotrophin signaling pathway","Notch signaling pathway","Notch NGF Pathway","25817714","no","no","","","","","","","","","","","","","The full text was not read because the abstract only talks about both pathway having some kind of effect on Muller cells, and does not suggest that they interact",""
+"Notch signaling pathway","Neurotrophin signaling pathway","Notch NGF Pathway","26092703","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only discussed how each pathway reacted to Wnt, not each other",""
+"Neurotrophin signaling pathway","Notch signaling pathway","Notch NGF Pathway","26092703","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only discussed how each pathway reacted to Wnt, not each other",""
+"Notch signaling pathway","NF-kappa B signaling pathway","Notch NF-kappa B Crosstalk","23926327","yes","no","activating","RBPJ","Q06330","UNIPROT","NFKB1","P19838","UNIPROT","Homo sapiens","hepatic stellate cell","BTO:0002741","inflammation","On the one hand, it has been shown that transcriptional repressor CBF1, the essential transcription factor downstream in Notch signaling, interacts with a dual NF-κB/CBF1-binding site (κB2) in the IκBα promoter and de-repress IκBα gene transcription leading to NF-κB activation in hematopoietic progenitor cells","Since it says that CBF1 interacts with NF-kappa B, that would be a direct interaction between Notch and NF-kappa B pathways",""
+"Notch signaling pathway","NF-kappa B signaling pathway","Notch NF-kappa B Crosstalk","23926327","yes","no","activating","RBPJ","Q06330","UNIPROT","NFKB1","P19838","UNIPROT","Homo sapiens","hematopoietic stem cell","BTO:0000725","inflammation","On the one hand, it has been shown that transcriptional repressor CBF1, the essential transcription factor downstream in Notch signaling, interacts with a dual NF-κB/CBF1-binding site (κB2) in the IκBα promoter and de-repress IκBα gene transcription leading to NF-κB activation in hematopoietic progenitor cells","Since it says that CBF1 interacts with NF-kappa B, that would be a direct interaction between Notch and NF-kappa B pathways",""
+"Notch signaling pathway","NF-kappa B signaling pathway","Notch NF-kappa B Crosstalk","23926327","yes","yes","activating","RBPJ","Q06330","UNIPROT","NFKBIA","P25963","UNIPROT","Homo sapiens","hepatic stellate cell","BTO:0002741","inflammation","On the one hand, it has been shown that transcriptional repressor CBF1, the essential transcription factor downstream in Notch signaling, interacts with a dual NF-κB/CBF1-binding site (κB2) in the IκBα promoter and de-repress IκBα gene transcription leading to NF-κB activation in hematopoietic progenitor cells","It seems that the interaction of CBF1 with NF-kappa B has an effect on the transcription of IkappaBalpha, so that would be transcriptional crosstalk",""
+"Notch signaling pathway","NF-kappa B signaling pathway","Notch NF-kappa B Crosstalk","23926327","yes","yes","activating","RBPJ","Q06330","UNIPROT","NFKBIA","P25963","UNIPROT","Homo sapiens","hematopoietic stem cell","BTO:0000725","inflammation","On the one hand, it has been shown that transcriptional repressor CBF1, the essential transcription factor downstream in Notch signaling, interacts with a dual NF-κB/CBF1-binding site (κB2) in the IκBα promoter and de-repress IκBα gene transcription leading to NF-κB activation in hematopoietic progenitor cells","It seems that the interaction of CBF1 with NF-kappa B has an effect on the transcription of IkappaBalpha, so that would be transcriptional crosstalk",""
+"NF-kappa B signaling pathway","Notch signaling pathway","Notch NF-kappa B Crosstalk","23926327","no","no","activating","","","","HES1/HEY1","Q14469/Q9Y5J3","UNIPROT","Homo sapiens","hepatic stellate cell","BTO:0002741","inflammation","On the other hand, it was found that activation of the canonical NF-κB pathway by TNF-α stimulation induced optimal expression of Notch targets such as Hes1 and Hey1 through a mechanism involving epigenetic activation of the Notch gene promoters by TNF-α stimulation","NF-kappa B didn't directly interact with Notch, but it did induce the transcription of Notch target genes, which is not considered crosstalk but the relationship was still recorded for information purposes",""
+"NF-kappa B signaling pathway","Notch signaling pathway","Notch NF-kappa B Crosstalk","23926327","no","no","activating","","","","HES1/HEY1","Q14469/Q9Y5J3","UNIPROT","Homo sapiens","hematopoietic stem cell","BTO:0000725","inflammation","On the other hand, it was found that activation of the canonical NF-κB pathway by TNF-α stimulation induced optimal expression of Notch targets such as Hes1 and Hey1 through a mechanism involving epigenetic activation of the Notch gene promoters by TNF-α stimulation","NF-kappa B didn't directly interact with Notch, but it did induce the transcription of Notch target genes, which is not considered crosstalk but the relationship was still recorded for information purposes",""
+"Notch signaling pathway","NF-kappa B signaling pathway","Notch NF-kappa B Crosstalk","22056382","yes","no","activating","","","","Cyld","Q80TQ2","UNIPROT","Mus musculus","pancreas","BTO:0000988","cancer","Notch/Hes1 signaling sustained NF-κB pathway activation by repressing the deubiquitinase CYLD, a negative Ikk complex regulator","The text seems to be describing direct interactions, and it also states that there is ""a bidirectional interaction between the NF-kappa B and Notch pathways...""",""
+"NF-kappa B signaling pathway","Notch signaling pathway","Notch NF-kappa B Crosstalk","22056382","yes","no","activating","","","","","","","Mus musculus","pancreas","BTO:0000988","cancer","Our data suggest that activation of NF-κB signaling can synergize with basal Notch signals to induce maximal expression of Notch target genes","The text seems to be describing direct interactions, and it also states that there is ""a bidirectional interaction between the NF-kappa B and Notch pathways..."" It also states that NF-kappa B maximized expression of Notch target genes, but that was through direct interaction with Notch",""
+"Notch signaling pathway","Prolactin signaling pathway","Notch Prolactin Crosstalk","25001242","no","no","","","","","","","","","","","","","The text mainly discussed the relationship that prolactin has with Estrogen and Progesterone and didn't mention any interaction with Notch",""
+"Prolactin signaling pathway","Notch signaling pathway","Notch Prolactin Crosstalk","25001242","no","no","","","","","","","","","","","","","The text mainly discussed the relationship that prolactin has with Estrogen and Progesterone and didn't mention any interaction with Notch",""
+"Notch signaling pathway","Prolactin signaling pathway","Notch Prolactin Pathway","24265293","no","no","","","","","","","","","","","","","There didn't seem to be an effect on Prolactin by Notch",""
+"Prolactin signaling pathway","Notch signaling pathway","Notch Prolactin Pathway","24265293","yes","yes","activating","JAK2","O60674","UNIPROT","JAG1","P78504","UNIPROT","Homo sapiens","colon","BTO:0000269","cancer","PRL also induced Notch signaling via the JAK2-ERK1/2 pathway by inducing JAG1 expression, leading to NICD accumulation along with the increase in expression of Notch target genes","Since JAK is part of the Prolactin pathway, JAK inducing JAG1 expression would be transcriptional crosstalk",""
+"Notch signaling pathway","Prolactin signaling pathway","Notch Prolactin Pathway","25397403","no","no","","","","","","","","","","","","","In the text neither pathway was discussed in the same context and there wasn't an interaction between them",""
+"Prolactin signaling pathway","Notch signaling pathway","Notch Prolactin Pathway","25397403","no","no","","","","","","","","","","","","","In the text neither pathway was discussed in the same context and there wasn't an interaction between them",""
+"Notch signaling pathway","Prolactin signaling pathway","Notch Prolactin Pathway","22523003","no","no","","","","","","","","","","","","","There didn't seem to be an effect on Prolactin by Notch",""
+"Prolactin signaling pathway","Notch signaling pathway","Notch Prolactin Pathway","22523003","yes","yes","inhibiting","ELF5","Q9UKW6","UNIPROT","NOTCH1","P46531","UNIPROT","Homo sapiens","mammary gland","BTO:0000817","differentiation","Based on our recent chromatin immunoprecipitation experiments demonstrating that there are Elf5-responsive elements in the Notch1 gene, we suspect that the increase in Notch1 levels is a direct consequence of the Elf5-loss","When the article discusses the effect that Elf5 has on Notch it seems to mainly discuss transcriptional effects, although it does say ""the upregulated Notch signaling in the absence of Elf5 is likely a direct effect and not merely due to a differentiation block"" which could mean there's direct interaction or it could be referring to the situation described in the sentence given",""
+"Notch signaling pathway","Prolactin signaling pathway","Notch Prolactin Pathway","24227653","no","no","","","","","","","","","","","","","The full text was not read because Prolactin was only mentioned once as a pituitary hormone, and it was not in the same context as Notch",""
+"Prolactin signaling pathway","Notch signaling pathway","Notch Prolactin Pathway","24227653","no","no","","","","","","","","","","","","","The full text was not read because Prolactin was only mentioned once as a pituitary hormone, and it was not in the same context as Notch",""
+"Notch signaling pathway","TGF-beta signaling pathway","Notch TGF-beta Crosstalk","24520074","yes","no","activating","Notch1/Notch4","Q01705/P31695","UNIPROT","Smad2:Smad3","Q62432:Q8BUN5","UNIPROT","Mus musculus","marrow cell","BTO:0001441","tumor progression","Heightened Dll4/Notch signaling in tumor cells magnified TGF-β-induced pSMAD2/3 signaling and was required to sustain TGF-β-induced tumor cell growth. ","The article states that Notch physically interacts with the TGF-beta pathway components to affect the TGF-beta pathway, and also says that inihibiting Notch significantly reduces SMADs phosphorylation, so the direct interaction is likely SMAD phosphorylation",""
+"Notch signaling pathway","TGF-beta signaling pathway","Notch TGF-beta Crosstalk","24520074","yes","no","activating","NOTCH1","P46531","UNIPROT","SMAD2","Q15796","UNIPROT","Homo sapiens","RCC 786-O cell","BTO:0003781","tumor progression","Notch signaling modulates expression of BMP family members and TGF-β target genes","cites 21826227: Notch inhibition also decreased phosphorylation of SMAD2 in cells stimulated with TGF-β1.",""
+"TGF-beta signaling pathway","Notch signaling pathway","Notch TGF-beta Crosstalk","24520074","yes","yes","activating","TGFB1","P01137","UNIPROT","JAG1","P78504","UNIPROT","Homo sapiens","marrow cell","BTO:0001441","tumor progression","Conversely, TGF-β induces expression of the Notch ligand Jagged1 and target gene Hey1","Since TGF-beta induces expression of these Notch pathway components that is transcriptional crosstalk",""
+"TGF-beta signaling pathway","Notch signaling pathway","Notch TGF-beta Crosstalk","23973264","yes","no","activating","SMAD3","P84022","UNIPROT","HEY1","Q9Y5J3","UNIPROT","Homo sapiens","HaCaT cell","BTO:0000552","","TGF-β-induced EMT could be blocked by Hey-1 or Jagged-1 knockdown or by pharmacological inactivation of Notch","There is not very much explanation of the relationship, but there does seem to be some interaction and the text does not suggest that it is transcriptional. The text was not available through PubMed, it had to be accessed through the library\r\n\r\nSarah: \r\ncites 14976548: This should be TGF-B to Notch signaling (originally other direction). Smad3 inhibition causes decrease in Hey1 activation.",""
+"TGF-beta signaling pathway","Notch signaling pathway","Notch TGF-beta Crosstalk","23973264","yes","yes","activating","","","","","","","Homo sapiens","many","","cancer stem cells","TGF-β signaling induces EMT in several systems, and increases the expression of Notch ligands","There is not much detail provided, but it is clear that TGF-beta transcriptional activates Notch. The text was not available through PubMed, it had to be accessed through the library",""
+"Notch signaling pathway","TGF-beta signaling pathway","Notch TGF-beta Crosstalk","22585622","yes","no","activating","NOTCH1","P46531","UNIPROT","SMAD3","P84022","UNIPROT","Homo sapiens","T-lymphocyte","BTO:0000782","differentiation","Notch signaling plays an important role on effector function of TGF-β and its signaling through an interaction of NICD and Smad 3","The text clearly explains that there is a direct binding of NICD to Smad 3 which results in the upregulation of TGF-beta",""
+"Notch signaling pathway","TGF-beta signaling pathway","Notch TGF-beta Crosstalk","22585622","yes","yes","activating","HES1","Q14469","UNIPROT","TGFBR2","P37173","UNIPROT","Homo sapiens","T-lymphocyte","BTO:0000782","differentiation","Here, we found that HES, the main transcription factor donwstream of Notch, induced a strong transactivation of TGF-ßRII by binding the TGF-βRII promoter through its DNA-binding activity","The text explains that HES directly bind to the promoter of TGF-betaRII, but HES is a target gene of the Notch pathway, although the article is saying that HES is a transcription factor of the Notch pathway, so the crosstalk isn't completely clear",""
+"TGF-beta signaling pathway","Notch signaling pathway","Notch TGF-beta Crosstalk","22585622","yes","yes","activating","","","","HES1","Q14469","UNIPROT","Homo sapiens","T-lymphocyte","BTO:0000782","differentiation","Taken together, this set of findings is consistent with the conclusion that Notch signaling plays an important role in facilitating TGF-β signaling in effector function and, in turn, TGF-β signaling amplifies these effects by upregulating HES.","The text says that TGF-beta upregulates HES, and it doesn't sound like it is transcriptional, but since HES is a target gene of Notch, the crosstalk is unclear since the article is saying that HES is a transcription factor of Notch",""
+"TGF-beta signaling pathway","Notch signaling pathway","Notch TGF-beta Crosstalk","22585622","yes","no","activating","SMAD3","P84022","UNIPROT","RBPJ","Q06330","UNIPROT","Homo sapiens","T-lymphocyte","BTO:0000782","differentiation","In addition, Smad3 and NICD signaling physically interact and such an interaction leads to recruitment of Smad3 to Notch target genes via binding to CSL, a key DNA-binding protein of the Notch pathway","The text states that the binding of Smad3 and NICD not only affects the TGF-beta pathway, but it also causes Smad 3 to bind to CSL to promote binding to Notch target genes",""
+"Notch signaling pathway","TNF signaling pathway","Notch TNF Crosstalk","22056382","no","no","","","","","","","","","","","","","The article was mainly about crosstalk between Notch and NF-kappa B, and just mentioned TNF-alpha as an activator of NF-kappa B",""
+"TNF signaling pathway","Notch signaling pathway","Notch TNF Crosstalk","22056382","no","no","","","","","","","","","","","","","The article was mainly about crosstalk between Notch and NF-kappa B, and just mentioned TNF-alpha as an activator of NF-kappa B",""
+"Notch signaling pathway","TNF signaling pathway","Notch TNF Crosstalk","23562747","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discussed each pathway's relationship to leptin",""
+"TNF signaling pathway","Notch signaling pathway","Notch TNF Crosstalk","23562747","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discussed each pathway's relationship to leptin",""
+"Notch signaling pathway","TNF signaling pathway","Notch TNF Crosstalk","24562309","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentioned each pathway as being activated by Splenic ILCs",""
+"TNF signaling pathway","Notch signaling pathway","Notch TNF Crosstalk","24562309","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentioned each pathway as being activated by Splenic ILCs",""
+"Notch signaling pathway","TNF signaling pathway","Notch TNF Cross-talk","24223152","no","no","","","","","","","","","","","","","The full paper was not read because the abstract didn't mention TNF",""
+"TNF signaling pathway","Notch signaling pathway","Notch TNF Cross-talk","24223152","no","no","","","","","","","","","","","","","The full paper was not read because the abstract didn't mention TNF",""
+"Notch signaling pathway","TNF signaling pathway","Notch TNF Cross-talk","12589049","no","no","","","","","","","","","","","","","TNF-alpha was only discussed as an activator for NF-kappa B, and then the article only talked about the crosstalk between Notch and NF-kappa B",""
+"TNF signaling pathway","Notch signaling pathway","Notch TNF Cross-talk","12589049","no","no","","","","","","","","","","","","","TNF-alpha was only discussed as an activator for NF-kappa B, and then the article only talked about the crosstalk between Notch and NF-kappa B",""
+"Notch signaling pathway","Toll-like receptor signaling pathway","Notch Toll-like receptor Crosstalk","24048326","no","no","","","","","","","","","","","","","The article states that the crosstalk between the two activates the NF-kappa B pathway, but it doesn't give any evidence of any new crosstalk than what was already found in the article",""
+"Toll-like receptor signaling pathway","Notch signaling pathway","Notch Toll-like receptor Crosstalk","24048326","yes","no","activating","Tlr5","Q9JLF7","UNIPROT","","","","Mus musculus","intestine","BTO:0000648","inflammation","Collectively, these findings strongly suggest that TLR5-mediated Notch1 and Jagged1 activation leads to increased functional activity for N1ICD-RBP-Jκ-mediated gene expression in intestinal epithelial cells","The text explains that flagelling and TLR5 can activate Notch1 and Jagged1 to induce the NICD and RBP-Jk to activate gene expression",""
+"Notch signaling pathway","Toll-like receptor signaling pathway","Notch Toll-like receptor Cross-talk","23203159","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned TLR once and only talked about how each interacts with NF-kappa B",""
+"Toll-like receptor signaling pathway","Notch signaling pathway","Notch Toll-like receptor Cross-talk","23203159","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned TLR once and only talked about how each interacts with NF-kappa B",""
+"Notch signaling pathway","Toll-like receptor signaling pathway","Notch Toll-like receptor Cross-talk","24223152","yes","yes","activating","","","","Tlr4","Q9QX05","UNIPROT","Rattus norvegicus","microglia","BTO:0000078","hypoxia","This suggests that Notch signaling may mediate hypoxia induced TLR4 expression which subsequently activates the MyD88 and TRAF6 expression","The text is very confusing about the relationship between Notch and TLR, although it is clear that Notch has some kind of effect on TLR. It seems that Notch has some sort of effect on the transcription or TLR4",""
+"Toll-like receptor signaling pathway","Notch signaling pathway","Notch Toll-like receptor Cross-talk","24223152","no","no","","","","","","","","","","","","","There only seemed to be an effect on TLR by Notch",""
+"Notch signaling pathway","Toll-like receptor signaling pathway","Notch Toll-like receptor Cross-talk","18166232","no","no","","","","","","","","","","","","","Notch was not mentioned in the article, only briefly mentioned in the abstract",""
+"Toll-like receptor signaling pathway","Notch signaling pathway","Notch Toll-like receptor Cross-talk","18166232","no","no","","","","","","","","","","","","","Notch was not mentioned in the article, only briefly mentioned in the abstract",""
+"Notch signaling pathway","Toll-like receptor signaling pathway","Notch Toll-like receptor Cross-talk","20870935","no","no","","","","","","","","","","","","","There only seemed to be an effect on Notch by TLR",""
+"Toll-like receptor signaling pathway","Notch signaling pathway","Notch Toll-like receptor Cross-talk","20870935","yes","no","activating","","","","RBPJ","Q06330","UNIPROT","Homo sapiens","macrophage","BTO:0000801","normal","We have now found that TLRs rapidly induce Jagged1 expression in a direct manner that is independent of new protein synthesis and is dependent on RBP-J and basal Notch signaling","It was made clear in the article that TLRs can induce the expression of Jagged1, but it seems that they can do this through a direct interaction with RBP-J and possibly other Notch components to enhance the expression of Jagged1",""
+"Notch signaling pathway","VEGF signaling pathway","Notch VEGF Crosstalk","21731759","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed how each pathway reacts to leptin",""
+"VEGF signaling pathway","Notch signaling pathway","Notch VEGF Crosstalk","21731759","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed how each pathway reacts to leptin",""
+"Notch signaling pathway","VEGF signaling pathway","Notch VEGF Crosstalk","25179535","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discussed how each pathway reacts to norepinephrine",""
+"VEGF signaling pathway","Notch signaling pathway","Notch VEGF Crosstalk","25179535","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discussed how each pathway reacts to norepinephrine",""
+"Notch signaling pathway","VEGF signaling pathway","Notch VEGF Crosstalk","23973264","no","no","","","","","","","","","","","","","VEGF is only mentioned once, and while the text says they have an interaction, it does not explain any further or go into any more detail",""
+"VEGF signaling pathway","Notch signaling pathway","Notch VEGF Crosstalk","23973264","no","no","","","","","","","","","","","","","VEGF is only mentioned once, and while the text says they have an interaction, it does not explain any further or go into any more detail",""
+"Notch signaling pathway","VEGF signaling pathway","Notch VEGF Cross-talk","23239744","yes","yes","inhibiting","","","","VEGFA,PGF","P15692,P49763","UNIPROT","Homo sapiens","acute myeloid leukemia cell","BTO:0001545","angiogenesis","The Notch/Dll4 pathway is capable of regulating the VEGF pathway by altering expression of its ligands (VEGF and PLGF) and receptors (NRP1, NRP2, VEGFR1 and VEGFR2","There is not much information given on the effect that Notch has on VEGF, but there seems to be some kind of transcriptional regulation",""
+"Notch signaling pathway","VEGF signaling pathway","Notch VEGF Cross-talk","23239744","yes","yes","inhibiting","","","","VEGFA,PGF","P15692,P49763","UNIPROT","Homo sapiens","bone marrow endothelial cell line","BTO:0003126","angiogenesis","The Notch/Dll4 pathway is capable of regulating the VEGF pathway by altering expression of its ligands (VEGF and PLGF) and receptors (NRP1, NRP2, VEGFR1 and VEGFR2","There is not much information given on the effect that Notch has on VEGF, but there seems to be some kind of transcriptional regulation",""
+"VEGF signaling pathway","Notch signaling pathway","Notch VEGF Cross-talk","23239744","yes","yes","activating","VEGFA","P15692","UNIPROT","PSEN1","P49768","UNIPROT","Homo sapiens","acute myeloid leukemia cell","BTO:0001545","angiogenesis","Indeed, VEGF is shown to upregulate both presenilin and ADAM10 expression, increase presenilin proteolytic processing and γ-secretase activity in endothelial cells, and result in activation of Dll4 and Notch1","The relationship between VEGF and Notch is very confusing in this article and is not explained well, but it seems that the effect that VEGF has on Notch is not direct",""
+"VEGF signaling pathway","Notch signaling pathway","Notch VEGF Cross-talk","23239744","yes","yes","activating","VEGFA","P15692","UNIPROT","PSEN1","P49768","UNIPROT","Homo sapiens","bone marrow endothelial cell line","BTO:0003126","angiogenesis","Indeed, VEGF is shown to upregulate both presenilin and ADAM10 expression, increase presenilin proteolytic processing and γ-secretase activity in endothelial cells, and result in activation of Dll4 and Notch1","The relationship between VEGF and Notch is very confusing in this article and is not explained well, but it seems that the effect that VEGF has on Notch is not direct",""
+"Notch signaling pathway","VEGF signaling pathway","Notch VEGF Cross-talk","23085847","yes","yes","inhibiting","","","","[FLT1/KDR/FLT4]","[P17948/P35968/P35916]","UNIPROT","Homo sapiens","endothelial cell","BTO:0001176","differentiation","Accordingly, endothelial Notch activation regulates the expression of the different VEGFRs (VEGFR1, 2, and 3) as well as the coreceptor Nrp1","The only relationship that seems to be described is transcriptional, but the transcriptional crosstalk is relatively clear",""
+"VEGF signaling pathway","Notch signaling pathway","Notch VEGF Cross-talk","23085847","yes","yes","activating","","","","DLL4","Q9NR61","UNIPROT","Homo sapiens","endothelial cell","BTO:0001176","differentiation","VEGF-A stimulation consistently increases the expression of Dll4 protein on the surface of human umbilical vein endothelial cells (HUVECs)","The only relationship that seems to be described is transcriptional, but the transcriptional crosstalk is relatively clear",""
+"Notch signaling pathway","Wnt signaling pathway","Notch Wnt Crosstalk","23602012","yes","no","inhibiting","NOTCH1","P46531","UNIPROT","[DVL1/DVL2/DVL3]","[O14640/O14641/Q92997]","UNIPROT","Homo sapiens","mesoderm","BTO:0000839","somitogenesis","NICD binds to active Dsh and thus inhibits the Wnt pathway","The text explains very well the relationship between Notch and Wnt and the effect that Notch has",""
+"Wnt signaling pathway","Notch signaling pathway","Notch Wnt Crosstalk","23602012","yes","yes","activating","LEF1:CTNNB1","Q9UJU2:P35222","UNIPROT","DLL1","O00548","UNIPROT","Homo sapiens","mesoderm","BTO:0000839","somitogenesis","Lef1 binds to β-catenin in the nucleus to form the Lef1-β-catenin complex that activates the expression of endogenous Dll1 in fibroblasts","There are many interactions between Notch and Wnt and it is clearly described that there is a transcriptional one",""
+"Wnt signaling pathway","Notch signaling pathway","Notch Wnt Crosstalk","23602012","yes","no","inhibiting","[DVL1/DVL2/DVL3]","[O14640/O14641/Q92997]","UNIPROT","NOTCH1","P46531","UNIPROT","Homo sapiens","mesoderm","BTO:0000839","somitogenesis","It is likely that Dsh blocks Notch signaling directly through binding of NICD","It is clearly explained that Wnt has a direct as well as transcriptional effect on Wnt. The text also discussed a relationship between Nkd1 and Hes7, but it does not specify what Nkd1 is a part of, and since Hes7 is a target gene of Notch the crosstalk of that situation is very ambiguous",""
+"Melanogenesis","Progesterone-mediated oocyte maturation","POMC Progesterone Crosstalk","14988602","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of either pathway in the abstract",""
+"Progesterone-mediated oocyte maturation","Melanogenesis","POMC Progesterone Crosstalk","14988602","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of either pathway in the abstract",""
+"Melanogenesis","Progesterone-mediated oocyte maturation","POMC Progesterone Crosstalk","22410481","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of either pathway in the abstract",""
+"Progesterone-mediated oocyte maturation","Melanogenesis","POMC Progesterone Crosstalk","22410481","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of either pathway in the abstract",""
+"Melanogenesis","Progesterone-mediated oocyte maturation","POMC Progesterone Crosstalk","11925385","no","no","","","","","","","","","","","","","The full article was not read becaus the abstract made no mention of Melanogenesis or any of its components and mainly talked about Progesterone and GnRH",""
+"Progesterone-mediated oocyte maturation","Melanogenesis","POMC Progesterone Crosstalk","11925385","no","no","","","","","","","","","","","","","The full article was not read becaus the abstract made no mention of Melanogenesis or any of its components and mainly talked about Progesterone and GnRH",""
+"Melanogenesis","Progesterone-mediated oocyte maturation","POMC Progesterone Crosstalk","203774","no","no","","","","","","","","","","","","","The abstract was not available on PubMed, but it was found through the library. Only the abstract was read and not the whole paper because there was no mention of Melanogenesis or any of its components",""
+"Progesterone-mediated oocyte maturation","Melanogenesis","POMC Progesterone Crosstalk","203774","no","no","","","","","","","","","","","","","The abstract was not available on PubMed, but it was found through the library. Only the abstract was read and not the whole paper because there was no mention of Melanogenesis or any of its components",""
+"Melanogenesis","Progesterone-mediated oocyte maturation","POMC Progesterone Crosstalk","178963","no","no","","","","","","","","","","","","","The abstract was not available on PubMed, but it was found through the library. Only the abstract was read and not the whole paper because there was no mention of Melanogenesis or any of its components",""
+"Progesterone-mediated oocyte maturation","Melanogenesis","POMC Progesterone Crosstalk","178963","no","no","","","","","","","","","","","","","The abstract was not available on PubMed, but it was found through the library. Only the abstract was read and not the whole paper because there was no mention of Melanogenesis or any of its components",""
+"Melanogenesis","Thyroid hormone synthesis","POMC TSH Pathway","23623838","no","no","","","","","","","","","","","","","The full text was not read because nothing about the thyroid was mentioned in the abstract",""
+"Thyroid hormone synthesis","Melanogenesis","POMC TSH Pathway","23623838","no","no","","","","","","","","","","","","","The full text was not read because nothing about the thyroid was mentioned in the abstract",""
+"Melanogenesis","Thyroid hormone synthesis","POMC TSH Pathway","14557433","no","no","","","","","","","","","","","","","The article discusses how each plays a role in obesity, but the text says that a POMC deficiency may cause TRH deficiency, which is what causes the release of TSH from the anterior pituitary, so the effect of POMC on TSH is indirect",""
+"Thyroid hormone synthesis","Melanogenesis","POMC TSH Pathway","14557433","no","no","","","","","","","","","","","","","The article discusses how each plays a role in obesity, but the text says that a POMC deficiency may cause TRH deficiency, which is what causes the release of TSH from the anterior pituitary, so the effect of POMC on TSH is indirect",""
+"Melanogenesis","Thyroid hormone synthesis","POMC TSH Pathway","21584660","no","no","","","","","","","","","","","","","The full article was not read because the abstract does not discuss POMC or any component of Melanogenesis",""
+"Thyroid hormone synthesis","Melanogenesis","POMC TSH Pathway","21584660","no","no","","","","","","","","","","","","","The full article was not read because the abstract does not discuss POMC or any component of Melanogenesis",""
+"Melanogenesis","Thyroid hormone synthesis","POMC TSH Pathway","2852195","no","no","","","","","","","","","","","","","The full article was not read because the abstract does not discuss POMC or any component of Melanogenesis",""
+"Thyroid hormone synthesis","Melanogenesis","POMC TSH Pathway","2852195","no","no","","","","","","","","","","","","","The full article was not read because the abstract does not discuss POMC or any component of Melanogenesis",""
+"Melanogenesis","Thyroid hormone synthesis","MSH TSH Crosstalk","7307052","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentions MSH once as reacting with human growth hormone, not TSH",""
+"Thyroid hormone synthesis","Melanogenesis","MSH TSH Crosstalk","7307052","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentions MSH once as reacting with human growth hormone, not TSH",""
+"Melanogenesis","mTOR signaling pathway","Melanogenesis mTOR Pathway","22577264","no","no","","","","","","","","","","","","","There only seemed to be an effect on Melanogenesis by mTOR",""
+"mTOR signaling pathway","Melanogenesis","Melanogenesis mTOR Pathway","22577264","yes","no","inhibiting","MTOR","P42345","UNIPROT","POMC","P01189","UNIPROT","Homo sapiens","melanoma cell","BTO:0000848","cancer","We further show that rapamycin and wortmannin synergize with α-MSH in stimulating melanin synthesis through the inhibition of mTOR and PI3K, respectively","The text doesn't give much evidence on this, but it does seem to suggest that alpha-MSH and rapamycin work together to promote melanin synthesis. Although the relationship seems that rapamycin has these effect through the inhibition of mTOR, so there may not be any crosstalk at all. The text does say that mTOR regulates melanin synthesis, but it does not say how, so maybe the relationships described in the article are how",""
+"mTOR signaling pathway","Melanogenesis","Melanogenesis mTOR Pathway","22577264","no","no","inhibiting","MTOR","P42345","UNIPROT","MITF","O75030","UNIPROT","Homo sapiens","melanoma cell","BTO:0000848","cancer","α-MSH-associated cAMP pathway promotes the activation of PKA and CREB, with the inhibition of the mTOR pathway by rapamycin increasing the expression of MITF, thereby simultaneously leading to the induction of melanogenic enzymes such as TYR and TYRP-1","The relationship between rapamycin and Melanogenesis is not explained completely clearly, an although it does say that it increases the expression of MITF, it doesn't say how, so it is much too ambiguous to say that there is crosstalk",""
+"Melanogenesis","mTOR signaling pathway","Melanogenesis mTOR Pathway","21838918","no","no","","","","","","","","","","","","","The text does indicate that there is some kind of effect that mTOR has on Melanogenesis, but it does not go into detail and gives no evidence that they interact",""
+"mTOR signaling pathway","Melanogenesis","Melanogenesis mTOR Pathway","21838918","no","no","","","","","","","","","","","","","The text does indicate that there is some kind of effect that mTOR has on Melanogenesis, but it does not go into detail and gives no evidence that they interact",""
+"Melanogenesis","mTOR signaling pathway","Melanogenesis mTOR Pathway","23792203","no","no","","","","","","","","","","","","","The full text was not read because the abstract mainly talks about the relationship between each pathway and GGA, and it stated that mTOR is not a key mechanism regulating the inhibition of melanin production",""
+"mTOR signaling pathway","Melanogenesis","Melanogenesis mTOR Pathway","23792203","no","no","","","","","","","","","","","","","The full text was not read because the abstract mainly talks about the relationship between each pathway and GGA, and it stated that mTOR is not a key mechanism regulating the inhibition of melanin production",""
+"Melanogenesis","mTOR signaling pathway","Melanogenesis mTOR Pathway","24361963","no","no","","","","","","","","","","","","","The full article was not read because mTOR was not mentioned in the abstract",""
+"mTOR signaling pathway","Melanogenesis","Melanogenesis mTOR Pathway","24361963","no","no","","","","","","","","","","","","","The full article was not read because mTOR was not mentioned in the abstract",""
+"Melanogenesis","mTOR signaling pathway","Melanogenesis mTOR Pathway","20073603","no","no","","","","","","","","","","","","","There only seemed to be an effect on Melanogenesis by mTOR",""
+"mTOR signaling pathway","Melanogenesis","Melanogenesis mTOR Pathway","20073603","no","no","activating","everolimus","drug","drug","CTSK","P43235","UNIPROT","Homo sapiens","lung squamous cell carcinoma cell","BTO:0003613","tumors","everolimus, a derivative of rapamycin, which targets the mTOR pathway, is able to specifically suppress cathepsin K expression in osteoclasts","The interaction of mTOR and MITF target genes is not technically crosstalk, but the relationship was still recorded for information purposes",""
+"Melanogenesis","Adipocytokine signaling pathway","MSH Leptin Crosstalk","20176366","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentioned leptin and only mentioned it in relationship to malnutrition and did not give any indications that it interacts with MSH",""
+"Adipocytokine signaling pathway","Melanogenesis","MSH Leptin Crosstalk","20176366","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentioned leptin and only mentioned it in relationship to malnutrition and did not give any indications that it interacts with MSH",""
+"Melanogenesis","Adipocytokine signaling pathway","MSH Leptin Cross-talk","19457101","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that leptin had a minimal effect on MSH and that MSH crosstalks with MAPK instead",""
+"Adipocytokine signaling pathway","Melanogenesis","MSH Leptin Cross-talk","19457101","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that leptin had a minimal effect on MSH and that MSH crosstalks with MAPK instead",""
+"Melanogenesis","Adipocytokine signaling pathway","MSH Leptin Cross-talk","22710442","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were only briefly mentioned as having some kind of role in the stress/feeding response, and there is no indication that they might react at all",""
+"Adipocytokine signaling pathway","Melanogenesis","MSH Leptin Cross-talk","22710442","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were only briefly mentioned as having some kind of role in the stress/feeding response, and there is no indication that they might react at all",""
+"Melanogenesis","Adipocytokine signaling pathway","MSH Leptin Pathway","23530005","no","no","","","","","","","","","","","","","In the text MSH is only mentioned very briefly and in not the same context as leptin",""
+"Adipocytokine signaling pathway","Melanogenesis","MSH Leptin Pathway","23530005","no","no","","","","","","","","","","","","","In the text MSH is only mentioned very briefly and in not the same context as leptin",""
+"Melanogenesis","Adipocytokine signaling pathway","MSH Leptin Pathway","22249810","no","no","","","","","","","","","","","","","The text does try to explain that there is some relationship between leptin and melanogenesis pathway components, but it is much too ambiguous to say that there is crosstalk",""
+"Adipocytokine signaling pathway","Melanogenesis","MSH Leptin Pathway","22249810","no","no","","","","","","","","","","","","","The text does try to explain that there is some relationship between leptin and melanogenesis pathway components, but it is much too ambiguous to say that there is crosstalk",""
+"Melanogenesis","ErbB signaling pathway","Melanogenesis ErbB Pathway","25889836","no","no","","","","","","","","","","","","","The full text was not read because each pathway was only briefly mentioned as being involved with genes that are involved in some kind of virus, but there is no suggestion that they interact",""
+"ErbB signaling pathway","Melanogenesis","Melanogenesis ErbB Pathway","25889836","no","no","","","","","","","","","","","","","The full text was not read because each pathway was only briefly mentioned as being involved with genes that are involved in some kind of virus, but there is no suggestion that they interact",""
+"Melanogenesis","ErbB signaling pathway","Melanogenesis EGFR Pathway","12427839","no","no","","","","","","","","","","","","","The full article was not read because EGFR was only briefly mentioned and in a different context than Melanogenesis",""
+"ErbB signaling pathway","Melanogenesis","Melanogenesis EGFR Pathway","12427839","no","no","","","","","","","","","","","","","The full article was not read because EGFR was only briefly mentioned and in a different context than Melanogenesis",""
+"Melanogenesis","ErbB signaling pathway","Melanogenesis EGFR Pathway","21883026","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were only very briefly mentioned and in different contexts",""
+"ErbB signaling pathway","Melanogenesis","Melanogenesis EGFR Pathway","21883026","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were only very briefly mentioned and in different contexts",""
+"Melanogenesis","ErbB signaling pathway","MSH ErbB Pathway","19225542","no","no","","","","","","","","","","","","","The full text was not read because neither pathway was mentioned in the abstract",""
+"ErbB signaling pathway","Melanogenesis","MSH ErbB Pathway","19225542","no","no","","","","","","","","","","","","","The full text was not read because neither pathway was mentioned in the abstract",""
+"Melanogenesis","ErbB signaling pathway","MSH EGFR Pathway","23065657","no","no","","","","","","","","","","","","","Both proteins were involved in a study of RAD51 overexpression in colorectal adenocarcinoma, but they were never mentioned to have any potential interactions/relationships",""
+"ErbB signaling pathway","Melanogenesis","MSH EGFR Pathway","23065657","no","no","","","","","","","","","","","","","Both proteins were involved in a study of RAD51 overexpression in colorectal adenocarcinoma, but they were never mentioned to have any potential interactions/relationships",""
+"Melanogenesis","Estrogen signaling pathway","Melanogenesis Estrogen Pathway","21745488","no","no","","","","","","","","","","","","","There only seemed to be an effect on Melanogenesis by Estrogen",""
+"Estrogen signaling pathway","Melanogenesis","Melanogenesis Estrogen Pathway","21745488","yes","yes","activating","","","","","","","Mus musculus","melanoma cell","BTO:0000848","cancer","DES binds to the membrane estrogen binding site and activates MITF gene transcription via putative transduction pathways in a rapid non-genomic manner","It seems clear that there is some kind of transcriptional effect on MITF by DEF, although the mechanism is unclear",""
+"Estrogen signaling pathway","Melanogenesis","Melanogenesis Estrogen Pathway","21745488","yes","yes","activating","","","","","","","Mus musculus","melanoma cell","BTO:0000848","cancer","DES-stimulated melanogenesis occurs through enhanced expression of the tyrosinase family, and these changes are generated through the cAMP-MITF signaling pathway.","The relationship between these two is not very clear. Although it is clear that DEF has some kind of transcriptional effect on MITF, but a mechanism is never provided",""
+"Melanogenesis","Estrogen signaling pathway","Melanogenesis Estrogen Pathway","15014071","no","no","","","","","","","","","","","","","The full text was not read because Estrogen is not mentioned in the abstract",""
+"Estrogen signaling pathway","Melanogenesis","Melanogenesis Estrogen Pathway","15014071","no","no","","","","","","","","","","","","","The full text was not read because Estrogen is not mentioned in the abstract",""
+"Melanogenesis","Estrogen signaling pathway","MSH Estrogen Pathway","14217987","no","no","","","","","","","","","","","","","The full text was not read because there was no abstract, but the paragraph provided had no mention of either pathway",""
+"Estrogen signaling pathway","Melanogenesis","MSH Estrogen Pathway","14217987","no","no","","","","","","","","","","","","","The full text was not read because there was no abstract, but the paragraph provided had no mention of either pathway",""
+"Melanogenesis","Estrogen signaling pathway","MSH Estrogen Pathway","19064943","no","no","","","","","","","","","","","","","The full article was not read because the abstract did not mention Melanogenesis",""
+"Estrogen signaling pathway","Melanogenesis","MSH Estrogen Pathway","19064943","no","no","","","","","","","","","","","","","The full article was not read because the abstract did not mention Melanogenesis",""
+"Melanogenesis","Estrogen signaling pathway","POMC Estrogen Pathway","24631553","no","no","","","","","","","","","","","","","The full article was not read because the abstract did not mention Melanogenesis",""
+"Estrogen signaling pathway","Melanogenesis","POMC Estrogen Pathway","24631553","no","no","","","","","","","","","","","","","The full article was not read because the abstract did not mention Melanogenesis",""
+"Melanogenesis","GnRH signaling pathway","Melanogenesis GnRH Pathway","25156242","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned each pathway as having genes that are affected by diet and there are no potential interactions mentioned",""
+"GnRH signaling pathway","Melanogenesis","Melanogenesis GnRH Pathway","25156242","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned each pathway as having genes that are affected by diet and there are no potential interactions mentioned",""
+"Melanogenesis","GnRH signaling pathway","MSH GnRH Crosstalk","391393","no","no","","","","","","","","","","","","","The full article was not read because GnRH is not mentioned in the abstract",""
+"GnRH signaling pathway","Melanogenesis","MSH GnRH Crosstalk","391393","no","no","","","","","","","","","","","","","The full article was not read because GnRH is not mentioned in the abstract",""
+"Melanogenesis","GnRH signaling pathway","MSH GnRH Crosstalk","8956325","no","no","","","","","","","","","","","","","The full article was not read because GnRH is not mentioned in the abstract",""
+"GnRH signaling pathway","Melanogenesis","MSH GnRH Crosstalk","8956325","no","no","","","","","","","","","","","","","The full article was not read because GnRH is not mentioned in the abstract",""
+"Melanogenesis","GnRH signaling pathway","MSH GnRH Pathway","20955748","no","no","","","","","","","","","","","","","The text indicates that CRH, not MSH, interacts with GnRH. The text was available online but had to be accessed through the library",""
+"GnRH signaling pathway","Melanogenesis","MSH GnRH Pathway","20955748","no","no","","","","","","","","","","","","","The text indicates that CRH, not MSH, interacts with GnRH. The text was available online but had to be accessed through the library",""
+"Melanogenesis","GnRH signaling pathway","MSH GnRH Pathway","9211127","no","no","","","","","","","","","","","","","The text explains that treating gonadotropic cells with MSH increases LH secretion, but it does not give clear evidence as to how this occurs, and mainly describes indirect relationships. The full text was not available through PubMed but was available through the library and has been saved",""
+"GnRH signaling pathway","Melanogenesis","MSH GnRH Pathway","9211127","no","no","","","","","","","","","","","","","The text explains that treating gonadotropic cells with MSH increases LH secretion, but it does not give clear evidence as to how this occurs, and mainly describes indirect relationships. The full text was not available through PubMed but was available through the library and has been saved",""
+"Melanogenesis","HIF-1 signaling pathway","Melanogenesis HIF-1 Pathway","24997364","yes","yes","activating","","","","","","","Homo sapiens","skin","BTO:0001253","melanoma","Therefore, these combined in vitro and in vivo data demonstrate that stimulation of melanogenesis increases the overall expression of HIF-1α and its nuclear localization","The text states that melanogenesis increases the expression of HIF-1alpha, but it does not give a mechanism",""
+"Melanogenesis","HIF-1 signaling pathway","Melanogenesis HIF-1 Pathway","24997364","yes","no","activating","ROS1","P08922","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","skin","BTO:0001253","melanoma","Both ROS and hypoxic environments are known to efficiently stimulate nuclear HIF-1α localization in other tumors","The article seems to suggest a direct interaction where ROS stimulates the nuclear localization of HIF-1alpha",""
+"HIF-1 signaling pathway","Melanogenesis","Melanogenesis HIF-1 Pathway","24997364","no","no","","","","","","","","","","","","","There only seemed to be an effect on HIF-1 by Melanogenesis",""
+"Melanogenesis","HIF-1 signaling pathway","Melanogenesis HIF-1 Pathway","24194964","no","no","","","","","","","","","","","","","The text indicates that there may be some relationship between the two pathways, but it does not give any details or evidence for any actual interactions",""
+"HIF-1 signaling pathway","Melanogenesis","Melanogenesis HIF-1 Pathway","24194964","no","no","","","","","","","","","","","","","The text indicates that there may be some relationship between the two pathways, but it does not give any details or evidence for any actual interactions",""
+"Melanogenesis","HIF-1 signaling pathway","MSH HIF-1 Pathway","15983061","yes","yes","activating","MITF","O75030","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","skin","BTO:0001253","melanoma","Interestingly, we report that the melanocyte-specific transcription factor, microphthalmia-associated transcription factor (MITF), binds to the Hif1a promoter and strongly stimulates its transcriptional activity","The text clearly states that MITF binds directly to the promoter of HIF-1alpha to stimulate transcriptional activity",""
+"HIF-1 signaling pathway","Melanogenesis","MSH HIF-1 Pathway","15983061","no","no","","","","","","","","","","","","","There only seemed to be an effect on HIF-1 by Melanogenesis",""
+"Melanogenesis","HIF-1 signaling pathway","POMC HIF-1 Pathway","21814490","no","no","","","","","","","","","","","","","The text doesn't really say anything conclusive about any interacts HIF might have with POMC, it is very ambiguous",""
+"HIF-1 signaling pathway","Melanogenesis","POMC HIF-1 Pathway","21814490","no","no","","","","","","","","","","","","","The text doesn't really say anything conclusive about any interacts HIF might have with POMC, it is very ambiguous",""
+"Melanogenesis","HIF-1 signaling pathway","MITF HIF-1 Pathway","21996743","no","no","","","","","","","","","","","","","The full text was not read because the abstract states that the relationship between MITF and HIF is not direct",""
+"HIF-1 signaling pathway","Melanogenesis","MITF HIF-1 Pathway","21996743","no","no","","","","","","","","","","","","","The full text was not read because the abstract states that the relationship between MITF and HIF is not direct",""
+"Melanogenesis","Hippo signaling pathway","MSH Hippo Pathway","23850191","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention MSH",""
+"Hippo signaling pathway","Melanogenesis","MSH Hippo Pathway","23850191","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention MSH",""
+"Melanogenesis","Hippo signaling pathway","MSH Hippo Pathway","25136132","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention MSH",""
+"Hippo signaling pathway","Melanogenesis","MSH Hippo Pathway","25136132","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention MSH",""
+"Melanogenesis","Hippo signaling pathway","MITF Hippo Pathway","25466249","no","no","","","","","","","","","","","","","The full article was not read because in the abstract both pathways are only talked about in relation to Pax3, which doesn't appear to be part of either pathway",""
+"Hippo signaling pathway","Melanogenesis","MITF Hippo Pathway","25466249","no","no","","","","","","","","","","","","","The full article was not read because in the abstract both pathways are only talked about in relation to Pax3, which doesn't appear to be part of either pathway",""
+"Melanogenesis","Hippo signaling pathway","MITF Hippo Pathway","20207963","no","no","","","","","","","","","","","","","The full paper was not read because MITF was only barely mentioned and in a different context than Hippo",""
+"Hippo signaling pathway","Melanogenesis","MITF Hippo Pathway","20207963","no","no","","","","","","","","","","","","","The full paper was not read because MITF was only barely mentioned and in a different context than Hippo",""
+"Melanogenesis","Insulin signaling pathway","Melanogenesis Insulin Pathway","25869056","no","no","","","","","","","","","","","","","The full paper was not read because IGF-1 was only briefly mentioned and there was no suggestion that it interacts with Melanogenesis",""
+"Insulin signaling pathway","Melanogenesis","Melanogenesis Insulin Pathway","25869056","no","no","","","","","","","","","","","","","The full paper was not read because IGF-1 was only briefly mentioned and there was no suggestion that it interacts with Melanogenesis",""
+"Melanogenesis","Insulin signaling pathway","Melanogenesis Insulin Pathway","20576005","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed that both pathways were related to obesity, but there was no indication that they interact",""
+"Insulin signaling pathway","Melanogenesis","Melanogenesis Insulin Pathway","20576005","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed that both pathways were related to obesity, but there was no indication that they interact",""
+"Melanogenesis","Insulin signaling pathway","Melanogenesis Insulin Pathway","18602000","no","no","","","","","","","","","","","","","The full article was not read because the abstract only briefly mentioned insulin as being related to GSK3beta, and it mostly talked about Melanogenesis and Wnt",""
+"Insulin signaling pathway","Melanogenesis","Melanogenesis Insulin Pathway","18602000","no","no","","","","","","","","","","","","","The full article was not read because the abstract only briefly mentioned insulin as being related to GSK3beta, and it mostly talked about Melanogenesis and Wnt",""
+"Melanogenesis","Insulin signaling pathway","Melanogenesis Insulin Pathway","18329644","no","no","","","","","","","","","","","","","The article suggested that insulin has some kind of effect on Melanogenesis, but there was no evidence in the text that there is any crosstalk or interactions. The full article was not available through PubMed, but it was found through the library",""
+"Insulin signaling pathway","Melanogenesis","Melanogenesis Insulin Pathway","18329644","no","no","","","","","","","","","","","","","The article suggested that insulin has some kind of effect on Melanogenesis, but there was no evidence in the text that there is any crosstalk or interactions. The full article was not available through PubMed, but it was found through the library",""
+"Melanogenesis","Insulin signaling pathway","Melanogenesis Insulin Pathway","22967711","no","no","","","","","","","","","","","","","The full text was not read because each pathway was only mentioned once in a list of pathways that are important to the topic of the paper, but there was no indication that there were any interactions between each pathway",""
+"Insulin signaling pathway","Melanogenesis","Melanogenesis Insulin Pathway","22967711","no","no","","","","","","","","","","","","","The full text was not read because each pathway was only mentioned once in a list of pathways that are important to the topic of the paper, but there was no indication that there were any interactions between each pathway",""
+"Melanogenesis","Jak-STAT signaling pathway","Melanogenesis Jak-STAT Pathway","9512481","no","no","","","","","","","","","","","","","The text indicates that there is some kind of effect that that MSH has on JAK2, but it is too confusing and ambiguous to determine the crosstalk",""
+"Jak-STAT signaling pathway","Melanogenesis","Melanogenesis Jak-STAT Pathway","9512481","no","no","","","","","","","","","","","","","The text indicates that there is some kind of effect that that MSH has on JAK2, but it is too confusing and ambiguous to determine the crosstalk",""
+"Melanogenesis","Jak-STAT signaling pathway","MSH Jak-STAT Pathway","23978534","no","no","","","","","","","","","","","","","The full text was not read because MSH is not mentioned in the abstract",""
+"Jak-STAT signaling pathway","Melanogenesis","MSH Jak-STAT Pathway","23978534","no","no","","","","","","","","","","","","","The full text was not read because MSH is not mentioned in the abstract",""
+"Melanogenesis","Jak-STAT signaling pathway","MSH Jak-STAT Pathway","23535516","no","no","","","","","","","","","","","","","The full article was not read because MSH was only briefly mentioned in the abstract and there was no indication that they have any relation to each other",""
+"Jak-STAT signaling pathway","Melanogenesis","MSH Jak-STAT Pathway","23535516","no","no","","","","","","","","","","","","","The full article was not read because MSH was only briefly mentioned in the abstract and there was no indication that they have any relation to each other",""
+"Melanogenesis","Jak-STAT signaling pathway","MSH Jak-STAT Pathway","25446929","no","no","","","","","","","","","","","","","The article suggests that MSH has some kind of activating effect on Jak-STAT, but it does not provide many details and is too ambiguous. The full article was not available through PubMed, but it was available through the library",""
+"Jak-STAT signaling pathway","Melanogenesis","MSH Jak-STAT Pathway","25446929","no","no","","","","","","","","","","","","","The article suggests that MSH has some kind of activating effect on Jak-STAT, but it does not provide many details and is too ambiguous. The full article was not available through PubMed, but it was available through the library",""
+"Melanogenesis","Jak-STAT signaling pathway","MSH Jak-STAT Pathway","23770121","no","no","","","","","","","","","","","","","The full article was not read because neither pathway was mentioned in the abstract",""
+"Jak-STAT signaling pathway","Melanogenesis","MSH Jak-STAT Pathway","23770121","no","no","","","","","","","","","","","","","The full article was not read because neither pathway was mentioned in the abstract",""
+"Melanogenesis","MAPK signaling pathway","Melanogenesis MAPK Pathway","24671267","no","no","","","","","","","","","","","","","There only seems to be an effect on MITF by MAPK",""
+"MAPK signaling pathway","Melanogenesis","Melanogenesis MAPK Pathway","24671267","yes","no","activating","MAPK3","P27361","UNIPROT","MITF","O75030","UNIPROT","Homo sapiens","melanocyte","BTO:0000847","heat/UVB","In addition, growing evidence has shown that MITF is activated by the mitogen-activated protein kinase (MAPK) signaling pathways, including extracellular signal-regulated kinases (ERK), c-jun N-terminal kinases (JNK) and p38 MAPK","There is not much detail, but it does seem that MAPK has an activating effect on MITF, and it does not seem transcriptional",""
+"Melanogenesis","MAPK signaling pathway","Melanogenesis MAPK Pathway","24680613","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed how each interacts with deltaT3, and there was no indication that they interact with each other",""
+"MAPK signaling pathway","Melanogenesis","Melanogenesis MAPK Pathway","24680613","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed how each interacts with deltaT3, and there was no indication that they interact with each other",""
+"Melanogenesis","MAPK signaling pathway","Melanogenesis MAPK Pathway","23872139","no","no","","","","","","","","","","","","","The article suggests that MAPK has some kind of effect on Melanogenesis, but there is not enough conclusive evidence given, and the text mainly discusses how each is affected by fenofibrate. The full text was not available through PubMed, but it was available through the library",""
+"MAPK signaling pathway","Melanogenesis","Melanogenesis MAPK Pathway","23872139","no","no","","","","","","","","","","","","","The article suggests that MAPK has some kind of effect on Melanogenesis, but there is not enough conclusive evidence given, and the text mainly discusses how each is affected by fenofibrate. The full text was not available through PubMed, but it was available through the library",""
+"Melanogenesis","MAPK signaling pathway","Melanogenesis MAPK Pathway","24689286","no","no","","","","","","","","","","","","","The text suggests a relationship between MSH and MAPK, but does not give many details and is too ambiguous. The full text was not available through PubMed, but was available through the library and has been saved",""
+"MAPK signaling pathway","Melanogenesis","Melanogenesis MAPK Pathway","24689286","no","no","","","","","","","","","","","","","The text suggests a relationship between MSH and MAPK, but does not give many details and is too ambiguous. The full text was not available through PubMed, but was available through the library and has been saved",""
+"Melanogenesis","MAPK signaling pathway","Melanogenesis MAPK Pathway","23810793","no","no","","","","","","","","","","","","","There only seems to be an effect on MITF by ERK. The full text was not available through PubMed, but it was available through the library",""
+"MAPK signaling pathway","Melanogenesis","Melanogenesis MAPK Pathway","23810793","yes","no","inhibiting","MAPK3/MAPK1","P27361/P28482","UNIPROT","MITF","O75030","UNIPROT","Homo sapiens","melanoma cell","BTO:0000848","OPA (skin whitening effects)","It has been reported that ERK is an important regulator of melanogenesis because ERK activation induces MITF phosphorylation and its subsequent degradation, and thus reduces melanin synthesis","It seems clear that ERK has the direct impact on MITF by inducing its phosphorylation. This seems direct and not transcriptional. The full text was not available through PubMed, but it was available through the library",""
+"Melanogenesis","Neurotrophin signaling pathway","Melanogenesis NGF Pathway","19438666","no","no","","","","","","","","","","","","","The full text was not read because there wasn't really any mention of Melanogenesis in the abstract",""
+"Neurotrophin signaling pathway","Melanogenesis","Melanogenesis NGF Pathway","19438666","no","no","","","","","","","","","","","","","The full text was not read because there wasn't really any mention of Melanogenesis in the abstract",""
+"Melanogenesis","Neurotrophin signaling pathway","POMC Neurotrophin Pathway","23964269","no","no","","","","","","","","","","","","","The full article was not read because there was no mention of POMC in the abstract",""
+"Neurotrophin signaling pathway","Melanogenesis","POMC Neurotrophin Pathway","23964269","no","no","","","","","","","","","","","","","The full article was not read because there was no mention of POMC in the abstract",""
+"Melanogenesis","Neurotrophin signaling pathway","MSH NGF Pathway","10514436","no","no","","","","","","","","","","","","","The full paper was not read because the MSH referred to in the abstract is mouse semaphorin H, not melanocyte stimulating hormone",""
+"Neurotrophin signaling pathway","Melanogenesis","MSH NGF Pathway","10514436","no","no","","","","","","","","","","","","","The full paper was not read because the MSH referred to in the abstract is mouse semaphorin H, not melanocyte stimulating hormone",""
+"Melanogenesis","Neurotrophin signaling pathway","MSH NGF Pathway","10355295","no","no","","","","","","","","","","","","","The full article was not read because both pathways were only mentioned in a list of pathways that are involved in differentiation of different cells/cells lines, but there is no suggestion that they interact at all",""
+"Neurotrophin signaling pathway","Melanogenesis","MSH NGF Pathway","10355295","no","no","","","","","","","","","","","","","The full article was not read because both pathways were only mentioned in a list of pathways that are involved in differentiation of different cells/cells lines, but there is no suggestion that they interact at all",""
+"Melanogenesis","Neurotrophin signaling pathway","MSH BDNF Pathway","25892444","yes","yes","activating","Mc4r","P70596","UNIPROT","Bdnf","P23363","UNIPROT","Rattus norvegicus","astrocyte","BTO:0000099","normal","We previously showed that astrocytes express only MC4R and that its activation induces BDNF expression through cAMP-PKA-CREB pathway in these cells","The text clearly states that MC4R induces the expression of BDNF and it explains that this occurs through a Melanogenesis pathway. The full text was not available on PubMed, but it was available through the library",""
+"Neurotrophin signaling pathway","Melanogenesis","MSH BDNF Pathway","25892444","no","no","","","","","","","","","","","","","There only seemed to be an effect on BDNF by MC4R. The full text was not available on PubMed, but it was available through the library",""
+"Melanogenesis","NF-kappa B signaling pathway","Melanogenesis NF-kappa B Pathway","23178856","no","no","","","","","","","","","","","","","The text suggested that there may be a relationship between the two pathways, but the article was too ambiguous and didn't state any conclusive evidence about any crosstalk. The full text was not available through PubMed, but it was availble through the library",""
+"NF-kappa B signaling pathway","Melanogenesis","Melanogenesis NF-kappa B Pathway","23178856","no","no","","","","","","","","","","","","","The text suggested that there may be a relationship between the two pathways, but the article was too ambiguous and didn't state any conclusive evidence about any crosstalk. The full text was not available through PubMed, but it was availble through the library",""
+"Melanogenesis","NF-kappa B signaling pathway","Melanogenesis NF-kappa B Pathway","24468889","no","no","","","","","","","","","","","","","The full text was not read because NF-kappa B was not mentioned in the abstract",""
+"NF-kappa B signaling pathway","Melanogenesis","Melanogenesis NF-kappa B Pathway","24468889","no","no","","","","","","","","","","","","","The full text was not read because NF-kappa B was not mentioned in the abstract",""
+"Melanogenesis","NF-kappa B signaling pathway","Melanogenesis NF-kappa B Pathway","22101249","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only talked about in relation to HCA, not each other",""
+"NF-kappa B signaling pathway","Melanogenesis","Melanogenesis NF-kappa B Pathway","22101249","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only talked about in relation to HCA, not each other",""
+"Melanogenesis","NF-kappa B signaling pathway","Melanogenesis NF-kappa B Pathway","21883026","no","no","","","","","","","","","","","","","The full text was not read because NF-kappa B was not mentioned in the abstract",""
+"NF-kappa B signaling pathway","Melanogenesis","Melanogenesis NF-kappa B Pathway","21883026","no","no","","","","","","","","","","","","","The full text was not read because NF-kappa B was not mentioned in the abstract",""
+"Melanogenesis","NF-kappa B signaling pathway","Melanogenesis NF-kappa B Pathway","15675961","no","no","","","","","","","","","","","","","The full article was not read because NF-kappa B was only mentioned once in the abstract and the abstract says that NF-kappa B was not related to the study being talked about",""
+"NF-kappa B signaling pathway","Melanogenesis","Melanogenesis NF-kappa B Pathway","15675961","no","no","","","","","","","","","","","","","The full article was not read because NF-kappa B was only mentioned once in the abstract and the abstract says that NF-kappa B was not related to the study being talked about",""
+"Melanogenesis","Prolactin signaling pathway","Melanogenesis Prolactin Pathway","9512481","no","no","","","","","","","","","","","","","The abstract mentions that alpha-MSH controls the release of prolactin, but then prolactin isn't mentioned anywhere else in the text",""
+"Prolactin signaling pathway","Melanogenesis","Melanogenesis Prolactin Pathway","9512481","no","no","","","","","","","","","","","","","The abstract mentions that alpha-MSH controls the release of prolactin, but then prolactin isn't mentioned anywhere else in the text",""
+"Melanogenesis","Prolactin signaling pathway","MSH Prolactin Pathway","313251","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed that both MSH and Prolactin are released by serotonin, but there is not indication that they interact at all",""
+"Prolactin signaling pathway","Melanogenesis","MSH Prolactin Pathway","313251","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed that both MSH and Prolactin are released by serotonin, but there is not indication that they interact at all",""
+"Melanogenesis","Prolactin signaling pathway","MSH Prolactin Pathway","24227653","no","no","","","","","","","","","","","","","The full article was not read because both pathways were only mentioned as being affected by a mutant Insm1 gene in mice, and there was no mention of any potential interaction between the two",""
+"Prolactin signaling pathway","Melanogenesis","MSH Prolactin Pathway","24227653","no","no","","","","","","","","","","","","","The full article was not read because both pathways were only mentioned as being affected by a mutant Insm1 gene in mice, and there was no mention of any potential interaction between the two",""
+"Melanogenesis","Prolactin signaling pathway","MSH Prolactin Pathway","9124336","no","no","","","","","","","","","","","","","The abstract mentions that alpha-MSH controls the release of prolactin, but then prolactin isn't mentioned anywhere else in the text",""
+"Prolactin signaling pathway","Melanogenesis","MSH Prolactin Pathway","9124336","no","no","","","","","","","","","","","","","The abstract mentions that alpha-MSH controls the release of prolactin, but then prolactin isn't mentioned anywhere else in the text",""
+"Melanogenesis","Prolactin signaling pathway","MSH Prolactin Pathway","10469985","no","no","","","","","","","","","","","","","The full paper was not read because MSH and Prolactin were both only mentioned to say that they darken skin, but there was no suggested interactions",""
+"Prolactin signaling pathway","Melanogenesis","MSH Prolactin Pathway","10469985","no","no","","","","","","","","","","","","","The full paper was not read because MSH and Prolactin were both only mentioned to say that they darken skin, but there was no suggested interactions",""
+"Melanogenesis","TGF-beta signaling pathway","Melanogenesis TGF-beta Pathway","19026785","no","no","","","","","","","","","","","","","The text suggests that TGF-beta has an effect on Melanogenesis, but it seems that the effect is through a regulator of Melanogenesis, which isn't part of either pathway, so the effect is indirect",""
+"TGF-beta signaling pathway","Melanogenesis","Melanogenesis TGF-beta Pathway","19026785","no","no","","","","","","","","","","","","","The text suggests that TGF-beta has an effect on Melanogenesis, but it seems that the effect is through a regulator of Melanogenesis, which isn't part of either pathway, so the effect is indirect",""
+"Melanogenesis","TGF-beta signaling pathway","Melanogenesis TGF-beta Pathway","15147727","no","no","","","","","","","","","","","","","The text suggests that TGF-beta has some kind of inhibiting effect on MITF/TYR, but it is saying that this occurs via the ERK pathway. Since ERK is part of the TGF-beta pathway, this might be crosstalk, but since ERK is also a pathway of its own, it sounds like it is not crosstalk. The full text was not available throug PubMed, but it was available through the library",""
+"TGF-beta signaling pathway","Melanogenesis","Melanogenesis TGF-beta Pathway","15147727","no","no","","","","","","","","","","","","","The text suggests that TGF-beta has some kind of inhibiting effect on MITF/TYR, but it is saying that this occurs via the ERK pathway. Since ERK is part of the TGF-beta pathway, this might be crosstalk, but since ERK is also a pathway of its own, it sounds like it is not crosstalk. The full text was not available throug PubMed, but it was available through the library",""
+"Melanogenesis","TGF-beta signaling pathway","Melanogenesis TGF-beta Pathway","11601654","no","no","","","","","","","","","","","","","There only seemed to be an effect on Melanogenesis by TGF-beta",""
+"TGF-beta signaling pathway","Melanogenesis","Melanogenesis TGF-beta Pathway","11601654","yes","yes","activating","BMP2","P12643","UNIPROT","TYR","P14679","UNIPROT","Homo sapiens","melanocyte","BTO:0000847","development","In summary, the cAMP and BMP-2 signaling pathways acting on melanocytes converge on the tyrosinase promoter to induce the expression of the tyrosinase gene and, in turn, to stimulate melanogenesis","Although the mechanism is not completely clear it seems that BMP-2 (most likely through Smads) binds to the TYR promoter to induce transcription and activate melanogenesis",""
+"Melanogenesis","TGF-beta signaling pathway","Melanogenesis TGF-beta Pathway","16837459","no","no","","","","","","","","","","","","","There only seemed to be an effect on Melanogenesis by TGF-beta",""
+"TGF-beta signaling pathway","Melanogenesis","Melanogenesis TGF-beta Pathway","16837459","yes","yes","inhibiting","BMP4","P12644","UNIPROT","TYR","P14679","UNIPROT","Homo sapiens","melanocyte","BTO:0000847","normal","Our studies demonstrate that BMP-4 inhibits melanogenesis in part via its effect on tyrosinase mRNA stability and in part through tyrosinase promoter repression","The mechanism of how BMP-4 regulates melanogenesis is not completely clear, but it seems that BMP-4 has some direct inhibiting effect on the transcription of tyrosinase",""
+"Melanogenesis","TGF-beta signaling pathway","Melanogenesis TGF-beta Pathway","12535196","no","no","","","","","","","","","","","","","The text only indicates that BMP has some role in regulating Melanogenesis, but it does not go into any detail or provide any support",""
+"TGF-beta signaling pathway","Melanogenesis","Melanogenesis TGF-beta Pathway","12535196","no","no","","","","","","","","","","","","","The text only indicates that BMP has some role in regulating Melanogenesis, but it does not go into any detail or provide any support",""
+"Melanogenesis","TNF signaling pathway","Melanogenesis TNF Pathway","19085934","no","no","","","","","","","","","","","","","The full text was not read because TNF was only mentioned once in a different context than Melanogenesis",""
+"TNF signaling pathway","Melanogenesis","Melanogenesis TNF Pathway","19085934","no","no","","","","","","","","","","","","","The full text was not read because TNF was only mentioned once in a different context than Melanogenesis",""
+"Melanogenesis","TNF signaling pathway","Melanogenesis TNF Pathway","25843058","no","no","","","","","","","","","","","","","The full article was not read because both pathways were only mentioned once and there was no indication that they interact at all",""
+"TNF signaling pathway","Melanogenesis","Melanogenesis TNF Pathway","25843058","no","no","","","","","","","","","","","","","The full article was not read because both pathways were only mentioned once and there was no indication that they interact at all",""
+"Melanogenesis","TNF signaling pathway","Melanogenesis TNF Pathway","9204951","no","no","","","","","","","","","","","","","The full paper was not read because Melanogenesis was only briefly mentioned and there was no indication that the pathways might interact at all",""
+"TNF signaling pathway","Melanogenesis","Melanogenesis TNF Pathway","9204951","no","no","","","","","","","","","","","","","The full paper was not read because Melanogenesis was only briefly mentioned and there was no indication that the pathways might interact at all",""
+"Melanogenesis","TNF signaling pathway","MSH TNF Pathway","22471953","no","no","","","","","","","","","","","","","The full article was not read because in the abstract TNF was only mentioned as releasing pro-inflammatory cytokines, and the cytokines were important to MSH, not TNF",""
+"TNF signaling pathway","Melanogenesis","MSH TNF Pathway","22471953","no","no","","","","","","","","","","","","","The full article was not read because in the abstract TNF was only mentioned as releasing pro-inflammatory cytokines, and the cytokines were important to MSH, not TNF",""
+"Melanogenesis","TNF signaling pathway","MSH TNF Pathway","21039420","yes","yes","inhibiting","NDP-alpha-MSH","hormone","hormone","Tnf","P06804","UNIPROT","Mus musculus","many","","multiple organ dysfunction syndrome","Indeed, NDP-α-MSH inhibited progression of the generalized inflammation by reducing mRNA expression of TNF-α, and by increasing that of IL-10, both in the liver and lung","It seems clear the MSH has a direct inhibitory effect on TNF expression. The text also says that MSH reduces TNF-alpha plasma levels, but it never indicates how this occurs",""
+"TNF signaling pathway","Melanogenesis","MSH TNF Pathway","21039420","no","no","","","","","","","","","","","","","There only seemed to be an effect on TNF by MSH",""
+"Melanogenesis","Toll-like receptor signaling pathway","POMC Toll-like receptor Pathway","25303559","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentioned POMC once and there was no indication of any crosstalk",""
+"Toll-like receptor signaling pathway","Melanogenesis","POMC Toll-like receptor Pathway","25303559","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentioned POMC once and there was no indication of any crosstalk",""
+"Melanogenesis","Toll-like receptor signaling pathway","TYR Toll-like receptor Cross-talk","17586693","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned TLR potentionally interacting with PI3K and MUC1, but not Tyr",""
+"Toll-like receptor signaling pathway","Melanogenesis","TYR Toll-like receptor Cross-talk","17586693","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned TLR potentionally interacting with PI3K and MUC1, but not Tyr",""
+"Melanogenesis","Toll-like receptor signaling pathway","TYR Toll-like receptor Cross-talk","17670892","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses both pathways interacting with STAT3, not each other",""
+"Toll-like receptor signaling pathway","Melanogenesis","TYR Toll-like receptor Cross-talk","17670892","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses both pathways interacting with STAT3, not each other",""
+"Melanogenesis","Toll-like receptor signaling pathway","TYR Toll-like receptor Pathway","22447928","no","no","","","","","","","","","","","","","The full paper was not read because the Tyr referred to in the abstract is not the same as the TYR in the Melanogenesis pathway",""
+"Toll-like receptor signaling pathway","Melanogenesis","TYR Toll-like receptor Pathway","22447928","no","no","","","","","","","","","","","","","The full paper was not read because the Tyr referred to in the abstract is not the same as the TYR in the Melanogenesis pathway",""
+"Melanogenesis","Toll-like receptor signaling pathway","TYR Toll-like receptor Pathway","23486465","no","no","","","","","","","","","","","","","The full paper was not read because the Tyr referred to in the abstract is not the same as the TYR in the Melanogenesis pathway",""
+"Toll-like receptor signaling pathway","Melanogenesis","TYR Toll-like receptor Pathway","23486465","no","no","","","","","","","","","","","","","The full paper was not read because the Tyr referred to in the abstract is not the same as the TYR in the Melanogenesis pathway",""
+"Melanogenesis","VEGF signaling pathway","Melanogenesis VEGF Pathway","24997364","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of VEGF in the abstract",""
+"VEGF signaling pathway","Melanogenesis","Melanogenesis VEGF Pathway","24997364","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of VEGF in the abstract",""
+"Melanogenesis","VEGF signaling pathway","Melanogenesis VEGF Pathway","19289254","no","no","","","","","","","","","","","","","The full article was not read because boht pathways were only mentioned once and both in a different context",""
+"VEGF signaling pathway","Melanogenesis","Melanogenesis VEGF Pathway","19289254","no","no","","","","","","","","","","","","","The full article was not read because boht pathways were only mentioned once and both in a different context",""
+"Melanogenesis","VEGF signaling pathway","Melanogenesis VEGF Pathway","24194964","no","no","","","","","","","","","","","","","The full paper was not read because VEGF was only mentioned once in the abstract as a target gene of HIF-1",""
+"VEGF signaling pathway","Melanogenesis","Melanogenesis VEGF Pathway","24194964","no","no","","","","","","","","","","","","","The full paper was not read because VEGF was only mentioned once in the abstract as a target gene of HIF-2",""
+"Melanogenesis","VEGF signaling pathway","MSH VEGF Pathway","24530634","yes","yes","inhibiting","POMC","P01189","UNIPROT","KDR","P35968","UNIPROT","Homo sapiens","endothelial cell","BTO:0001176","angiogenesis","The present study unveils that α-MSH inhibits angiogenesis by downregulating VEGF/VEGFR2 expression in endothelial cells","The paper states that alpha-MSH has an inhibitory effect on VEGF/VEGFR2 expression",""
+"VEGF signaling pathway","Melanogenesis","MSH VEGF Pathway","24530634","no","no","","","","","","","","","","","","","There only seemed to be an effect on VEGF by MSH",""
+"Melanogenesis","VEGF signaling pathway","MSH VEGF Pathway","17010568","no","no","","","","","","","","","","","","","Only the abstract was read because VEGF and MSH were both only mentioned as being measured as part of the study talked about, but there was no indication of any interactions between them",""
+"VEGF signaling pathway","Melanogenesis","MSH VEGF Pathway","17010568","no","no","","","","","","","","","","","","","Only the abstract was read because VEGF and MSH were both only mentioned as being measured as part of the study talked about, but there was no indication of any interactions between them",""
+"Melanogenesis","Wnt signaling pathway","Melanogenesis Wnt Cross-talk","21040502","yes","no","activating","PRKACA","P17612","UNIPROT","CTNNB1","P35222","UNIPROT","Homo sapiens","melanocyte","BTO:0000847","differentiation","Consistent with previous studies, activated PKA phosphorylated β-catenin at Ser675, thus stabilizing the cytoplasmic and nuclear protein","The text specifically states that PKA phosphorylates beta-catenin directly at Ser675, which stabilizes the protein and results in upregulated Wnt target genes",""
+"Wnt signaling pathway","Melanogenesis","Melanogenesis Wnt Cross-talk","21040502","yes","no","activating","CTNNB1","P35222","UNIPROT","CREB1","P16220","UNIPROT","Homo sapiens","melanocyte","BTO:0000847","differentiation","Co-immunoprecipitation assays revealed a physical interaction between CREB and β-catenin following α-MSH or forskolin treatment, suggesting that β-catenin functionally cooperates with CREB to promote MITF gene transcription","The text states that CREB and beta-catenin physically interact to promote MITF gene expression",""
+"Progesterone-mediated oocyte maturation","Thyroid hormone synthesis","Progesterone TSH Cross-talk","12163847","no","no","","","","","","","","","","","","","The full text was not read because progesterone and TSH were both only mentioned as having to do with different cancers, and there was no indication that they interact at all",""
+"Thyroid hormone synthesis","Progesterone-mediated oocyte maturation","Progesterone TSH Cross-talk","12163847","no","no","","","","","","","","","","","","","The full text was not read because progesterone and TSH were both only mentioned as having to do with different cancers, and there was no indication that they interact at all",""
+"Progesterone-mediated oocyte maturation","Thyroid hormone synthesis","Progesterone TSH Pathway","10734466","no","no","","","","","","","","","","","","","The text mainly discusses that TSH has an effect on the secretion of progesterone, but does not really interact with progesterone directly",""
+"Thyroid hormone synthesis","Progesterone-mediated oocyte maturation","Progesterone TSH Pathway","10734466","no","no","","","","","","","","","","","","","The text mainly discusses that TSH has an effect on the secretion of progesterone, but does not really interact with progesterone directly",""
+"Progesterone-mediated oocyte maturation","Thyroid hormone synthesis","Progesterone TSH Pathway","25596636","no","no","","","","","","","","","","","","","The full article was not read because the abstract mainly discusses the levels of each hormone during pregnancy, but it does not suggest that they interact at all",""
+"Thyroid hormone synthesis","Progesterone-mediated oocyte maturation","Progesterone TSH Pathway","25596636","no","no","","","","","","","","","","","","","The full article was not read because the abstract mainly discusses the levels of each hormone during pregnancy, but it does not suggest that they interact at all",""
+"Progesterone-mediated oocyte maturation","Thyroid hormone synthesis","Progesterone TSH Pathway","11750866","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were only mentioned once and in a different context",""
+"Thyroid hormone synthesis","Progesterone-mediated oocyte maturation","Progesterone TSH Pathway","11750866","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were only mentioned once and in a different context",""
+"Progesterone-mediated oocyte maturation","Thyroid hormone synthesis","Progesterone TG Pathway","22190699","no","no","","","","","","","","","","","","","The full article was not read because the TG in the abstract meant transgenic, not the TG from the TSH pathway",""
+"Thyroid hormone synthesis","Progesterone-mediated oocyte maturation","Progesterone TG Pathway","22190699","no","no","","","","","","","","","","","","","The full article was not read because the TG in the abstract meant transgenic, not the TG from the TSH pathway",""
+"Progesterone-mediated oocyte maturation","mTOR signaling pathway","Progesterone mTOR Crosstalk","25671104","no","no","","","","","","","","","","","","","The full article was not read because Progesterone and mTOR were both only mentioned once and mTOR was only mentioned to crosstalk with MAPK",""
+"mTOR signaling pathway","Progesterone-mediated oocyte maturation","Progesterone mTOR Crosstalk","25671104","no","no","","","","","","","","","","","","","The full article was not read because Progesterone and mTOR were both only mentioned once and mTOR was only mentioned to crosstalk with MAPK",""
+"Progesterone-mediated oocyte maturation","mTOR signaling pathway","Progesterone mTOR Crosstalk","17283241","no","no","","","","","","","","","","","","","The full text was not read because Progesterone was only mentioned once and in a different context than mTOR",""
+"mTOR signaling pathway","Progesterone-mediated oocyte maturation","Progesterone mTOR Crosstalk","17283241","no","no","","","","","","","","","","","","","The full text was not read because Progesterone was only mentioned once and in a different context than mTOR",""
+"Progesterone-mediated oocyte maturation","mTOR signaling pathway","Progesterone mTOR Pathway","25733860","no","no","","","","","","","","","","","","","The full article was not read because the abstract mainly discusses a relationship between mTOR and estradiol, and mentions that Progesterone does not have an effect on mTOR",""
+"mTOR signaling pathway","Progesterone-mediated oocyte maturation","Progesterone mTOR Pathway","25733860","no","no","","","","","","","","","","","","","The full article was not read because the abstract mainly discusses a relationship between mTOR and estradiol, and mentions that Progesterone does not have an effect on mTOR",""
+"Progesterone-mediated oocyte maturation","mTOR signaling pathway","Progesterone mTOR Pathway","23541542","yes","no","inhibiting","P4","hormone","hormone","","","","Homo sapiens","myometrium","BTO:0000907","normal","Later on, the rise in P4 levels will antagonize the proliferative effects of E2 and downregulate mTOR signalling","The article isn't completely clear on the exact interactions between the two, but it does sugges that there is a direct inhibitorty effect on mTOR by Progesterone",""
+"Progesterone-mediated oocyte maturation","mTOR signaling pathway","Progesterone mTOR Pathway","23541542","yes","yes","activating","","","","","","","Homo sapiens","myometrium","BTO:0000907","normal","In ovariectomized mice, P4 treatment significantly increased levels of S6K in the dorsal hippocampus","The crosstalk is unclear because the article suggests transcriptional regulation of mTOR by Progesterone, but no mechanism is provided",""
+"mTOR signaling pathway","Progesterone-mediated oocyte maturation","Progesterone mTOR Pathway","23541542","no","no","","","","","","","","","","","","","There only seemed to be an effect on mTOR by P4",""
+"Progesterone-mediated oocyte maturation","mTOR signaling pathway","Progesterone mTOR Pathway","26172931","no","no","","","","","","","","","","","","","The full article was not available through PubMed or the library, but based on the abstract it seems that Everolimus, an mTOR inhibitor, also has some kind of effect on Progesterone, but Everolimus does not appear to be part of the mTOR pathway so it is most likely not crosstalk",""
+"mTOR signaling pathway","Progesterone-mediated oocyte maturation","Progesterone mTOR Pathway","26172931","no","no","","","","","","","","","","","","","The full article was not available through PubMed or the library, but based on the abstract it seems that Everolimus, an mTOR inhibitor, also has some kind of effect on Progesterone, but Everolimus does not appear to be part of the mTOR pathway so it is most likely not crosstalk",""
+"Progesterone-mediated oocyte maturation","Adipocytokine signaling pathway","Progesterone Adipocytokine Pathway","19849856","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed leptin affecting the production of progesterone and other steriods, but not actually interacting with it",""
+"Adipocytokine signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Adipocytokine Pathway","19849856","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed leptin affecting the production of progesterone and other steriods, but not actually interacting with it",""
+"Progesterone-mediated oocyte maturation","Adipocytokine signaling pathway","Progesterone Leptin Crosstalk","12379828","no","no","","","","","","","","","","","","","The full article was not read because Leptin was not mentioned in the abstract",""
+"Adipocytokine signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Leptin Crosstalk","12379828","no","no","","","","","","","","","","","","","The full article was not read because Leptin was not mentioned in the abstract",""
+"Progesterone-mediated oocyte maturation","Adipocytokine signaling pathway","Progesterone Leptin Cross-talk","25686566","no","no","","","","","","","","","","","","","The full paper was not read because leptin and progesterone were both only mentioned once in the abstract and both in a different context",""
+"Adipocytokine signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Leptin Cross-talk","25686566","no","no","","","","","","","","","","","","","The full paper was not read because leptin and progesterone were both only mentioned once in the abstract and both in a different context",""
+"Progesterone-mediated oocyte maturation","Adipocytokine signaling pathway","Progesterone Leptin Pathway","24746835","no","no","","","","","","","","","","","","","Only the abstract was read because progesterone was only mentioned once and there was no suggestion of any potential interaction between the two pathways",""
+"Adipocytokine signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Leptin Pathway","24746835","no","no","","","","","","","","","","","","","Only the abstract was read because progesterone was only mentioned once and there was no suggestion of any potential interaction between the two pathways",""
+"Progesterone-mediated oocyte maturation","Adipocytokine signaling pathway","Progesterone Leptin Pathway","24377862","no","no","","","","","","","","","","","","","The full text was not read because progesterone and leptin were both not mentioned in the abstract",""
+"Adipocytokine signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Leptin Pathway","24377862","no","no","","","","","","","","","","","","","The full text was not read because progesterone and leptin were both not mentioned in the abstract",""
+"Progesterone-mediated oocyte maturation","ErbB signaling pathway","Progesterone ErbB Crosstalk","22359195","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only mentioned in a different context and there was no indication of any potential interactions",""
+"ErbB signaling pathway","Progesterone-mediated oocyte maturation","Progesterone ErbB Crosstalk","22359195","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only mentioned in a different context and there was no indication of any potential interactions",""
+"Progesterone-mediated oocyte maturation","ErbB signaling pathway","Progesterone ErbB Crosstalk","24469992","no","no","","","","","","","","","","","","","The full article was not read because neither pathway is mentioned in the abstract",""
+"ErbB signaling pathway","Progesterone-mediated oocyte maturation","Progesterone ErbB Crosstalk","24469992","no","no","","","","","","","","","","","","","The full article was not read because neither pathway is mentioned in the abstract",""
+"Progesterone-mediated oocyte maturation","ErbB signaling pathway","Progesterone ErbB Crosstalk","24674874","no","no","","","","","","","","","","","","","The full paper was not read because progesterone is not mentioned in the abstract",""
+"ErbB signaling pathway","Progesterone-mediated oocyte maturation","Progesterone ErbB Crosstalk","24674874","no","no","","","","","","","","","","","","","The full paper was not read because progesterone is not mentioned in the abstract",""
+"Progesterone-mediated oocyte maturation","ErbB signaling pathway","Progesterone ErbB Crosstalk","23679233","no","no","","","","","","","","","","","","","The full paper was not read because progesterone is not mentioned in the abstract",""
+"ErbB signaling pathway","Progesterone-mediated oocyte maturation","Progesterone ErbB Crosstalk","23679233","no","no","","","","","","","","","","","","","The full paper was not read because progesterone is not mentioned in the abstract",""
+"Progesterone-mediated oocyte maturation","ErbB signaling pathway","Progesterone ErbB Crosstalk","19031973","no","no","","","","","","","","","","","","","Only the abstract was read because it mainly discussed crosstalk between ErbB and p53",""
+"ErbB signaling pathway","Progesterone-mediated oocyte maturation","Progesterone ErbB Crosstalk","19031973","no","no","","","","","","","","","","","","","Only the abstract was read because it mainly discussed crosstalk between ErbB and p54",""
+"Progesterone-mediated oocyte maturation","Estrogen signaling pathway","Progesterone Estrogen Crosstalk","25100707","no","no","","","","","","","","","","","","","The abstract suggested a potential interaction, but the article mainly discusses the role that estrogen and progesterone have in cancer, and how they interact with Akt",""
+"Estrogen signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Estrogen Crosstalk","25100707","no","no","","","","","","","","","","","","","The abstract suggested a potential interaction, but the article mainly discusses the role that estrogen and progesterone have in cancer, and how they interact with Akt",""
+"Progesterone-mediated oocyte maturation","Estrogen signaling pathway","Progesterone Estrogen Crosstalk","24879953","no","no","","","","","","","","","","","","","The full text was not read because E2 and P4 were both mentioned as part of the study that is discussed in the abstract, but there is no indication of any potential interactions",""
+"Estrogen signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Estrogen Crosstalk","24879953","no","no","","","","","","","","","","","","","The full text was not read because E2 and P4 were both mentioned as part of the study that is discussed in the abstract, but there is no indication of any potential interactions",""
+"Progesterone-mediated oocyte maturation","Estrogen signaling pathway","Progesterone Estrogen Crosstalk","23675265","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses the crosstalk between each pathway and insulin, not crosstalk with each other",""
+"Estrogen signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Estrogen Crosstalk","23675265","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses the crosstalk between each pathway and insulin, not crosstalk with each other",""
+"Progesterone-mediated oocyte maturation","Estrogen signaling pathway","Progesterone Estrogen Crosstalk","25587053","no","no","","","","","","","","","","","","","The article suggested that there is an interaction between ER and PR, and it also says that PR is a downstream effector of estrogen signaling, but there are no other details and the text is too ambiguous to determine crosstalk",""
+"Estrogen signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Estrogen Crosstalk","25587053","no","no","","","","","","","","","","","","","The article suggested that there is an interaction between ER and PR, and it also says that PR is a downstream effector of estrogen signaling, but there are no other details and the text is too ambiguous to determine crosstalk",""
+"Progesterone-mediated oocyte maturation","Estrogen signaling pathway","Progesterone Estrogen Crosstalk","25252859","no","no","","","","","","","","","","","","","The full paper was not read because estrogen and progesterone were both only mentioned as having a part in breast cancer, but there was no indication of any potential interactions",""
+"Estrogen signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Estrogen Crosstalk","25252859","no","no","","","","","","","","","","","","","The full paper was not read because estrogen and progesterone were both only mentioned as having a part in breast cancer, but there was no indication of any potential interactions",""
+"Progesterone-mediated oocyte maturation","GnRH signaling pathway","Progesterone GnRH Crosstalk","3935863","no","no","","","","","","","","","","","","","The abstract suggested a potential relationship between progesterone and GnRH, but progesterone was not mentioned anywhere else in the text. The full text was not available through PubMed, but it was available through the library",""
+"GnRH signaling pathway","Progesterone-mediated oocyte maturation","Progesterone GnRH Crosstalk","3935863","no","no","","","","","","","","","","","","","The abstract suggested a potential relationship between progesterone and GnRH, but progesterone was not mentioned anywhere else in the text. The full text was not available through PubMed, but it was available through the library",""
+"Progesterone-mediated oocyte maturation","GnRH signaling pathway","Progesterone GnRH Crosstalk","10655292","no","no","","","","","","","","","","","","","Progesterone was only mentioned to say that its levels were low throughout the study being performed in the article",""
+"GnRH signaling pathway","Progesterone-mediated oocyte maturation","Progesterone GnRH Crosstalk","10655292","no","no","","","","","","","","","","","","","Progesterone was only mentioned to say that its levels were low throughout the study being performed in the article",""
+"Progesterone-mediated oocyte maturation","GnRH signaling pathway","Progesterone GnRH Crosstalk","11925385","no","no","","","","","","","","","","","","","The text suggests that there may be some kind of relationship between GnRH and progesterone, but it never discusses any interactions between the two",""
+"GnRH signaling pathway","Progesterone-mediated oocyte maturation","Progesterone GnRH Crosstalk","11925385","no","no","","","","","","","","","","","","","The text suggests that there may be some kind of relationship between GnRH and progesterone, but it never discusses any interactions between the two",""
+"Progesterone-mediated oocyte maturation","GnRH signaling pathway","Progesterone GnRH Crosstalk","6999295","no","no","","","","","","","","","","","","","The text did not contain an abstract, and the text had to be found through the library, but there was a summary provided. The full text was not read because neither pathway was mentioned in the summary",""
+"GnRH signaling pathway","Progesterone-mediated oocyte maturation","Progesterone GnRH Crosstalk","6999295","no","no","","","","","","","","","","","","","The text did not contain an abstract, and the text had to be found through the library, but there was a summary provided. The full text was not read because neither pathway was mentioned in the summary",""
+"Progesterone-mediated oocyte maturation","GnRH signaling pathway","Progesterone GnRH Crosstalk","1091117","no","no","","","","","","","","","","","","","The full article was not read because GnRH was not mentioned in the abstract",""
+"GnRH signaling pathway","Progesterone-mediated oocyte maturation","Progesterone GnRH Crosstalk","1091117","no","no","","","","","","","","","","","","","The full article was not read because GnRH was not mentioned in the abstract",""
+"Progesterone-mediated oocyte maturation","HIF-1 signaling pathway","Progesterone HIF-1 Crosstalk","10822009","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of HIF-1 in the abstract",""
+"HIF-1 signaling pathway","Progesterone-mediated oocyte maturation","Progesterone HIF-1 Crosstalk","10822009","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of HIF-1 in the abstract",""
+"Progesterone-mediated oocyte maturation","HIF-1 signaling pathway","Progesterone HIF-1 Cross-talk","23665105","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of HIF-1 in the abstract",""
+"HIF-1 signaling pathway","Progesterone-mediated oocyte maturation","Progesterone HIF-1 Cross-talk","23665105","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of HIF-1 in the abstract",""
+"Progesterone-mediated oocyte maturation","HIF-1 signaling pathway","Progesterone HIF-1 Cross-talk","10619402","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of HIF-1 in the abstract",""
+"HIF-1 signaling pathway","Progesterone-mediated oocyte maturation","Progesterone HIF-1 Cross-talk","10619402","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of HIF-1 in the abstract",""
+"Progesterone-mediated oocyte maturation","HIF-1 signaling pathway","Progesterone HIF-1 Pathway","24670641","no","no","","","","","","","","","","","","","The full article was not read because both pathways were only mentioned to discuss breast cancer, and there was no potential interaction mentioned",""
+"HIF-1 signaling pathway","Progesterone-mediated oocyte maturation","Progesterone HIF-1 Pathway","24670641","no","no","","","","","","","","","","","","","The full article was not read because both pathways were only mentioned to discuss breast cancer, and there was no potential interaction mentioned",""
+"Progesterone-mediated oocyte maturation","HIF-1 signaling pathway","Progesterone HIF-1 Pathway","23850146","no","no","","","","","","","","","","","","","The full paper was not read because neither pathway was mentioned in the abstract",""
+"HIF-1 signaling pathway","Progesterone-mediated oocyte maturation","Progesterone HIF-1 Pathway","23850146","no","no","","","","","","","","","","","","","The full paper was not read because neither pathway was mentioned in the abstract",""
+"Progesterone-mediated oocyte maturation","Hippo signaling pathway","Progesterone Hippo Pathway","25870251","no","no","","","","","","","","","","","","","The full article was not read because progesterone was only mentioned as having a part in breast cancer, and there was no indication of any potential interactions between progesterone and hippo",""
+"Hippo signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Hippo Pathway","25870251","no","no","","","","","","","","","","","","","The full article was not read because progesterone was only mentioned as having a part in breast cancer, and there was no indication of any potential interactions between progesterone and hippo",""
+"Progesterone-mediated oocyte maturation","Hippo signaling pathway","Progesterone Yap Pathway","21214929","no","no","","","","","","","","","","","","","The full text was not read because progesterone was not mentioned in the abstract",""
+"Hippo signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Yap Pathway","21214929","no","no","","","","","","","","","","","","","The full text was not read because progesterone was not mentioned in the abstract",""
+"Progesterone-mediated oocyte maturation","Hippo signaling pathway","Progesterone Yap Pathway","16772533","no","no","","","","","","","","","","","","","There only seemed to be an effect on Progesterone by YAP",""
+"Hippo signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Yap Pathway","16772533","yes","yes","inhibiting","YAP1","P46937","UNIPROT","PGR","P06401","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","These data suggest that YAP can modulate the ligand-dependent transcriptional activity of PR and ER via WBP-2.","The text does not provide much detail, but it seems that when YAP binds to WBP-2, those together regulate the transcription of PR",""
+"Progesterone-mediated oocyte maturation","Hippo signaling pathway","PR Hippo Pathway","25201729","no","no","","","","","","","","","","","","","The full paper was not read because progesterone was not mentioned in the abstract",""
+"Hippo signaling pathway","Progesterone-mediated oocyte maturation","PR Hippo Pathway","25201729","no","no","","","","","","","","","","","","","The full paper was not read because progesterone was not mentioned in the abstract",""
+"Progesterone-mediated oocyte maturation","Hippo signaling pathway","PR Hippo Pathway","24262985","no","no","","","","","","","","","","","","","The full paper was not read because progesterone was not mentioned in the abstract",""
+"Hippo signaling pathway","Progesterone-mediated oocyte maturation","PR Hippo Pathway","24262985","no","no","","","","","","","","","","","","","The full paper was not read because progesterone was not mentioned in the abstract",""
+"Progesterone-mediated oocyte maturation","Insulin signaling pathway","Progesterone Insulin Crosstalk","23675265","no","no","","","","","","","","","","","","","There only seemed to be an effect on Progesterone by Insulin",""
+"Insulin signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Insulin Crosstalk","23675265","yes","no","inhibiting","INS","P01308","UNIPROT","PGR","P06401","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","And, as such, the down regulation of estrogen or progesterone receptor number by insulin in neutrophils under normal or under the pathologic condition of breast cancer might result in the impairment of systemic synthesis of interferon α which is also reported to be synthesized in these cells in the presence of NO","The text wasn't completely clear on the mechanisms of Insulin affecting Progesterone, but it doesn't appear to be transcriptional, it seems to be direct",""
+"Progesterone-mediated oocyte maturation","Insulin signaling pathway","Progesterone Insulin Crosstalk","23944361","yes","yes","activating","","","","","","","Homo sapiens","breast","BTO:0000149","cancer","IRS-2 levels were significantly induced by treatment with both progesterone and synthetic progestin in PR-positive breast cancer cells","The text explains that progesterone increases IRS-2 levels, but does not give details or a mechanism, so the crosstalk is unclear. The full text was not available through PubMed but was available through the library and has been saved",""
+"Insulin signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Insulin Crosstalk","23944361","no","no","","","","","","","","","","","","","There only seemed to be an effect on IRS-2 by progesterone. The full text was not available through PubMed but was available through the library and has been saved",""
+"Progesterone-mediated oocyte maturation","Insulin signaling pathway","Progesterone Insulin Crosstalk","18367392","no","no","","","","","","","","","","","","","The full article was not read because the relationship between Progesterone and Insulin described in the abstract was indirect",""
+"Insulin signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Insulin Crosstalk","18367392","no","no","","","","","","","","","","","","","The full article was not read because the relationship between Progesterone and Insulin described in the abstract was indirect",""
+"Progesterone-mediated oocyte maturation","Insulin signaling pathway","Progesterone Insulin Crosstalk","14534541","yes","yes","activating","progesterone","hormone","hormone","IRS2","Q9Y4H2","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","In summary, these data suggest that the progesterone effect on IRS-2 in breast cancer cells is mediated by transcriptional mechanisms.","The article does not provide a lot of detail and is confusing, but it seems that Progesterone has some kind of transcriptional inducing effect on IRS-2",""
+"Insulin signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Insulin Crosstalk","14534541","no","no","","","","","","","","","","","","","There only seemed to be an effect on Insulin by Progesterone",""
+"Progesterone-mediated oocyte maturation","Insulin signaling pathway","Progesterone Insulin Crosstalk","4858165","no","no","","","","","","","","","","","","","The full text was not read because neither pathway was mentioned in the abstract. The abstract and the full text were both not available through PubMed, but they were available through the library and have been saved",""
+"Insulin signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Insulin Crosstalk","4858165","no","no","","","","","","","","","","","","","The full text was not read because neither pathway was mentioned in the abstract. The abstract and the full text were both not available through PubMed, but they were available through the library and have been saved",""
+"Progesterone-mediated oocyte maturation","Jak-STAT signaling pathway","Progesterone Jak-STAT Cross-talk","24416641","yes","no","activating","progesterone","hormone","hormone","JAK2/STAT3","O60674/P40763","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Interestingly, treatment of T-47D breast cancer cells with synthetic progesterone induces tyrosine phosphorylation of JAK2 and an increase in STAT5 protein level","The text states that Progesterone has a direct and transcriptional effect on Jak-STAT",""
+"Progesterone-mediated oocyte maturation","Jak-STAT signaling pathway","Progesterone Jak-STAT Cross-talk","24416641","yes","yes","activating","progesterone","hormone","hormone","STAT5A/STAT3","P42229/P40763","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Additionally, progesterone upregulated the activity and expression of STAT3 and stimulated breast cancer growth","The text states that Progesterone has a direct and transcriptional effect on Jak-STAT",""
+"Jak-STAT signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Jak-STAT Cross-talk","24416641","no","no","","","","","","","","","","","","","There only seemed to be an effect on Jak-STAT by Progesterone",""
+"Progesterone-mediated oocyte maturation","Jak-STAT signaling pathway","Progesterone Jak-STAT Pathway","22748021","yes","no","activating","progesterone","hormone","hormone","JAK1,JAK2,STAT1","P23458,O60674,P42224","UNIPROT","Homo sapiens","semen","BTO:0001230","normal","Treatment of capacitated spermatozoa with physiological concentrations of progesterone leads to increased phosphorylation of both the isoforms of JAK1, JAK2 and STAT1 in a time-dependent manner","The text does not provide a lot of detail on the mechanism of how progesterone phosphorylates Jak1/2 and STAT1. It mentions that progesterone stimulates an influx of calcium, which then activates Jak-STAT, in which case this would most likely not be crosstalk, but then it goes on to explain that the time of calcium release does not correspond with the time of Jak-STAT activation. This indicates that the effect is most likely direct",""
+"Jak-STAT signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Jak-STAT Pathway","22748021","no","no","","","","","","","","","","","","","There only seemed to be an effect on Jak-STAT by Progesterone",""
+"Progesterone-mediated oocyte maturation","Jak-STAT signaling pathway","Progesterone Jak-STAT Pathway","23525700","no","no","","","","","","","","","","","","","The text indicates that progesterone has some kind of effect on the Jak-STAT pathway, but it seems that the effect is indirect in this case",""
+"Jak-STAT signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Jak-STAT Pathway","23525700","no","no","","","","","","","","","","","","","The text indicates that progesterone has some kind of effect on the Jak-STAT pathway, but it seems that the effect is indirect in this case",""
+"Progesterone-mediated oocyte maturation","Jak-STAT signaling pathway","Progesterone Jak-STAT Pathway","11476770","yes","no","inhibiting","progesterone","hormone","hormone","STAT4","Q14765","UNIPROT","Homo sapiens","semen","BTO:0001230","normal","Despite the presence of STAT 4 protein, no phosphorylation of STAT 4 was detected in A23187-treated sperm and marked inhibition of STAT 4 phosphorylation was detected in progesterone-treated sperm","There is not a lot of detail provided, but it seems that progesterone has some strong inhibiting effect on the phosohorylation of STAT4, and there is no suggestion that it is indirect",""
+"Jak-STAT signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Jak-STAT Pathway","11476770","no","no","","","","","","","","","","","","","There only seemed to be an effect on Jak-STAT by Progesterone",""
+"Progesterone-mediated oocyte maturation","Jak-STAT signaling pathway","Progesterone Jak-STAT Pathway","22911368","no","no","","","","","","","","","","","","","The text does not mention any interaction between the two pathways",""
+"Jak-STAT signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Jak-STAT Pathway","22911368","no","no","","","","","","","","","","","","","The text does not mention any interaction between the two pathways",""
+"Progesterone-mediated oocyte maturation","MAPK signaling pathway","Progesterone MAPK Crosstalk","21720253","no","no","","","","","","","","","","","","","The text hardly mentioned progesterone, it mainly discussed MAPK and estrogen",""
+"MAPK signaling pathway","Progesterone-mediated oocyte maturation","Progesterone MAPK Crosstalk","21720253","no","no","","","","","","","","","","","","","The text hardly mentioned progesterone, it mainly discussed MAPK and estrogen",""
+"Progesterone-mediated oocyte maturation","MAPK signaling pathway","Progesterone MAPK Crosstalk","22321971","no","no","","","","","","","","","","","","","The full text was not read because there was only brief mention of progesterone in the abstract and MAPK was only mentioned to react with androgen receptor",""
+"MAPK signaling pathway","Progesterone-mediated oocyte maturation","Progesterone MAPK Crosstalk","22321971","no","no","","","","","","","","","","","","","The full text was not read because there was only brief mention of progesterone in the abstract and MAPK was only mentioned to react with androgen receptor",""
+"Progesterone-mediated oocyte maturation","MAPK signaling pathway","Progesterone MAPK Crosstalk","15112327","no","no","","","","","","","","","","","","","The text only discusses MAPK having an effect on Progesterone synthesis, but not actually interacting with it",""
+"MAPK signaling pathway","Progesterone-mediated oocyte maturation","Progesterone MAPK Crosstalk","15112327","no","no","","","","","","","","","","","","","The text only discusses MAPK having an effect on Progesterone synthesis, but not actually interacting with it",""
+"Progesterone-mediated oocyte maturation","MAPK signaling pathway","Progesterone MAPK Crosstalk","25671104","no","no","","","","","","","","","","","","","The full article was not read because the abstract does not mention any potential interactions between the two pathways",""
+"MAPK signaling pathway","Progesterone-mediated oocyte maturation","Progesterone MAPK Crosstalk","25671104","no","no","","","","","","","","","","","","","The full article was not read because the abstract does not mention any potential interactions between the two pathways",""
+"Progesterone-mediated oocyte maturation","MAPK signaling pathway","Progesterone MAPK Crosstalk","18072255","no","no","","","","","","","","","","","","","The full paper was not read because progesterone was only mentioned once and in a different context than MAPK",""
+"MAPK signaling pathway","Progesterone-mediated oocyte maturation","Progesterone MAPK Crosstalk","18072255","no","no","","","","","","","","","","","","","The full paper was not read because progesterone was only mentioned once and in a different context than MAPK",""
+"Progesterone-mediated oocyte maturation","Neurotrophin signaling pathway","Progesterone Neurotrophin Pathway","8756297","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only mentioned once in the abstract and there was no indication of any potential interactions",""
+"Neurotrophin signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Neurotrophin Pathway","8756297","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only mentioned once in the abstract and there was no indication of any potential interactions",""
+"Progesterone-mediated oocyte maturation","Neurotrophin signaling pathway","Progesterone BDNF Pathway","23154302","yes","yes","activating","P4","hormone","hormone","BDNF","P23560","UNIPROT","Homo sapiens","brain","BTO:0000142","injury","P4 increases BDNF expression in various brain injury models","The text states that progesterone increases the expression of BDNF, although it does not give the exact mechanism",""
+"Neurotrophin signaling pathway","Progesterone-mediated oocyte maturation","Progesterone BDNF Pathway","23154302","no","no","","","","","","","","","","","","","There only seemed to be an effect on BDNF by P4",""
+"Progesterone-mediated oocyte maturation","Neurotrophin signaling pathway","Progesterone BDNF Pathway","25603414","no","no","","","","","","","","","","","","","The full article was nto read because both pathways were mentioned in a different context",""
+"Neurotrophin signaling pathway","Progesterone-mediated oocyte maturation","Progesterone BDNF Pathway","25603414","no","no","","","","","","","","","","","","","The full article was nto read because both pathways were mentioned in a different context",""
+"Progesterone-mediated oocyte maturation","Neurotrophin signaling pathway","Progesterone BDNF Pathway","22450229","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned progesterone and BDNF interacting with PI3K/Akt",""
+"Neurotrophin signaling pathway","Progesterone-mediated oocyte maturation","Progesterone BDNF Pathway","22450229","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned progesterone and BDNF interacting with PI3K/Akt",""
+"Progesterone-mediated oocyte maturation","Neurotrophin signaling pathway","Progesterone BDNF Pathway","19175406","no","no","","","","","","","","","","","","","The text states that progesterone does not really have an effect on BDNF",""
+"Neurotrophin signaling pathway","Progesterone-mediated oocyte maturation","Progesterone BDNF Pathway","19175406","no","no","","","","","","","","","","","","","The text states that progesterone does not really have an effect on BDNF",""
+"Progesterone-mediated oocyte maturation","NF-kappa B signaling pathway","Progesterone NF-kappa B Crosstalk","17607667","no","no","","","","","","","","","","","","","The full text was not read because progesterone was not mentioned in the abstract",""
+"NF-kappa B signaling pathway","Progesterone-mediated oocyte maturation","Progesterone NF-kappa B Crosstalk","17607667","no","no","","","","","","","","","","","","","The full text was not read because progesterone was not mentioned in the abstract",""
+"Progesterone-mediated oocyte maturation","NF-kappa B signaling pathway","Progesterone NF-Kappa B Cross-talk","9440809","no","no","","","","","","","","","","","","","The text only mentions how each interacts with glucocorticoid receptor, not each other",""
+"NF-kappa B signaling pathway","Progesterone-mediated oocyte maturation","Progesterone NF-Kappa B Cross-talk","9440809","no","no","","","","","","","","","","","","","The text only mentions how each interacts with glucocorticoid receptor, not each other",""
+"Progesterone-mediated oocyte maturation","NF-kappa B signaling pathway","Progesterone NF-Kappa B Cross-talk","7659084","no","no","","","","","","","","","","","","","The only relationship between progesterone and NFkB described in the text is indirect. The full text was not available through PubMed but was available through the library and has been requested",""
+"NF-kappa B signaling pathway","Progesterone-mediated oocyte maturation","Progesterone NF-Kappa B Cross-talk","7659084","no","no","","","","","","","","","","","","","The only relationship between progesterone and NFkB described in the text is indirect. The full text was not available through PubMed but was available through the library and has been requested",""
+"Progesterone-mediated oocyte maturation","NF-kappa B signaling pathway","Progesterone NF-Kappa B Cross-talk","10453354","no","no","","","","","","","","","","","","","The text states that much more study is needed to determine a reciprocal relationship",""
+"NF-kappa B signaling pathway","Progesterone-mediated oocyte maturation","Progesterone NF-Kappa B Cross-talk","10453354","yes","no","inhibiting","RELA","Q04206","UNIPROT","PGR","P06401","UNIPROT","Homo sapiens","many","","immune/inflammatory response","As with ER, both our group and others have demonstrated a repressive effect of p65 on PR (B-form) transactivation, and the physical interaction of NF-κB and PR has also been demonstrated in vitro","It seems clear that there is a direct interaction between NF-kB and PR which has a repressive effect on the progesterone pathway",""
+"Progesterone-mediated oocyte maturation","NF-kappa B signaling pathway","Progesterone NF-kappa B Pathway","25819032","no","no","","","","","","","","","","","","","The full paper was not read because NF-kappa B was not mentioned in the abstract",""
+"NF-kappa B signaling pathway","Progesterone-mediated oocyte maturation","Progesterone NF-kappa B Pathway","25819032","no","no","","","","","","","","","","","","","The full paper was not read because NF-kappa B was not mentioned in the abstract",""
+"Progesterone-mediated oocyte maturation","Prolactin signaling pathway","Progesterone Prolactin Crosstalk","22193050","yes","no","activating","Pgr","Q00175","UNIPROT","Stat5a","P42230","UNIPROT","Mus musculus","mammary gland","BTO:0000817","normal/breast cancer","By ChIP assay, PR and Stat5 each bound to separate sites on the Id4 gene in response to P4 or PRL, whereas a PR-Stat5 complex was assembled in response to treatment with P4+PRL","It seems that Id4 is a target gene of both prolactin and progesterone, and when Stat5 is activated by prolactin, it forms a complex with progesterone receptor to bind to DNA and induce expression of Id4. This appears to be a bidirectional crosstalk because the complex formed induces expression of a target gene of both pathways, but it just happens to be the same gene (which is why there was no transcriptional crosstalk recorded)",""
+"Prolactin signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Prolactin Crosstalk","22193050","yes","no","activating","Stat5a","P42230","UNIPROT","Pgr","Q00175","UNIPROT","Mus musculus","mammary gland","BTO:0000817","normal/breast cancer","These data suggest that interactions between PR and Stat5, at the target gene level, contribute to the additive functional effect of P4 and PRL on expression of Id4","It seems that Id4 is a target gene of both prolactin and progesterone, and when Stat5 is activated by prolactin, it forms a complex with progesterone receptor to bind to DNA and induce expression of Id4. This appears to be a bidirectional crosstalk because the complex formed induces expression of a target gene of both pathways, but it just happens to be the same gene (which is why there was no transcriptional crosstalk recorded)",""
+"Progesterone-mediated oocyte maturation","TGF-beta signaling pathway","Progesterone TGF-beta Crosstalk","25422352","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned each pathway as having a part in some thyroid disorders, but there was no indication of any potential interactions between the two",""
+"TGF-beta signaling pathway","Progesterone-mediated oocyte maturation","Progesterone TGF-beta Crosstalk","25422352","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned each pathway as having a part in some thyroid disorders, but there was no indication of any potential interactions between the two",""
+"Progesterone-mediated oocyte maturation","TGF-beta signaling pathway","Progesterone TGF-beta Crosstalk","17283241","no","no","","","","","","","","","","","","","The full article was not read because progesterone was only mentioned once to say that the production of progesterone is increased by FSH, but there was no mention of any potential interactions with TGF-beta",""
+"TGF-beta signaling pathway","Progesterone-mediated oocyte maturation","Progesterone TGF-beta Crosstalk","17283241","no","no","","","","","","","","","","","","","The full article was not read because progesterone was only mentioned once to say that the production of progesterone is increased by FSH, but there was no mention of any potential interactions with TGF-beta",""
+"Progesterone-mediated oocyte maturation","TGF-beta signaling pathway","Progesterone TGF-beta Cross-talk","23127506","no","no","","","","","","","","","","","","","The text mainly describes an indirect relationship between progesterone and TGF-beta, and discusses crosstalk between TGF-beta and FSH/EGFR. The full text was not available through PubMed but was available through the library and has been requested",""
+"TGF-beta signaling pathway","Progesterone-mediated oocyte maturation","Progesterone TGF-beta Cross-talk","23127506","no","no","","","","","","","","","","","","","The text mainly describes an indirect relationship between progesterone and TGF-beta, and discusses crosstalk between TGF-beta and FSH/EGFR. The full text was not available through PubMed but was available through the library and has been requested",""
+"Progesterone-mediated oocyte maturation","TGF-beta signaling pathway","Progesterone TGF-beta Cross-talk","10619356","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were mentioned in a different context",""
+"TGF-beta signaling pathway","Progesterone-mediated oocyte maturation","Progesterone TGF-beta Cross-talk","10619356","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were mentioned in a different context",""
+"Progesterone-mediated oocyte maturation","TGF-beta signaling pathway","Progesterone TGF-beta Cross-talk","17695423","no","no","","","","","","","","","","","","","The text was much too ambiguous and did not provide enough information to determine crosstalk",""
+"TGF-beta signaling pathway","Progesterone-mediated oocyte maturation","Progesterone TGF-beta Cross-talk","17695423","no","no","","","","","","","","","","","","","The text was much too ambiguous and did not provide enough information to determine crosstalk",""
+"Progesterone-mediated oocyte maturation","TNF signaling pathway","Progesterone TNF Crosstalk","26002969","no","no","","","","","","","","","","","","","The full text was not read because TNF was only mentioned to say that it mediates IL-6 and IL-8 secretion",""
+"TNF signaling pathway","Progesterone-mediated oocyte maturation","Progesterone TNF Crosstalk","26002969","no","no","","","","","","","","","","","","","The full text was not read because TNF was only mentioned to say that it mediates IL-6 and IL-8 secretion",""
+"Progesterone-mediated oocyte maturation","TNF signaling pathway","Progesterone TNF Crosstalk","24213015","no","no","","","","","","","","","","","","","The full article was not read because progesterone was only mentioned once in the abstract to say that it influences the human endometrium",""
+"TNF signaling pathway","Progesterone-mediated oocyte maturation","Progesterone TNF Crosstalk","24213015","no","no","","","","","","","","","","","","","The full article was not read because progesterone was only mentioned once in the abstract to say that it influences the human endometrium",""
+"Progesterone-mediated oocyte maturation","TNF signaling pathway","Progesterone TNF Crosstalk","17607667","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not mention progesterone",""
+"TNF signaling pathway","Progesterone-mediated oocyte maturation","Progesterone TNF Crosstalk","17607667","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not mention progesterone",""
+"Progesterone-mediated oocyte maturation","TNF signaling pathway","Progesterone TNF Crosstalk","14667978","no","no","","","","","","","","","","","","","Only the abstract was read because it only mentions each pathway being involved in apoptosis but does not indicate that they might interact",""
+"TNF signaling pathway","Progesterone-mediated oocyte maturation","Progesterone TNF Crosstalk","14667978","no","no","","","","","","","","","","","","","Only the abstract was read because it only mentions each pathway being involved in apoptosis but does not indicate that they might interact",""
+"Progesterone-mediated oocyte maturation","TNF signaling pathway","Progesterone TNF Cross-talk","23665105","no","no","","","","","","","","","","","","","The text suggests that progesterone has some kind of inhibitory effect on TNF, but the mechanism is too unclear to determine crosstalk",""
+"TNF signaling pathway","Progesterone-mediated oocyte maturation","Progesterone TNF Cross-talk","23665105","no","no","","","","","","","","","","","","","The text suggests that progesterone has some kind of inhibitory effect on TNF, but the mechanism is too unclear to determine crosstalk",""
+"Progesterone-mediated oocyte maturation","Toll-like receptor signaling pathway","Progesterone Toll-like receptor Pathway","24142728","yes","yes","inhibiting","progesterone","hormone","hormone","NFKBIA","P25963","UNIPROT","Homo sapiens","many","","pre-eclampsia","It was found that the mRNA expression levels of TLR4, MyD88 and NF-kB were significantly decreased with the concentrations of progesterone increasing, but those of IkB-alpha protein significantly increased","Only a transcriptional effect on TLR is mentioned, no direct interactions",""
+"Toll-like receptor signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Toll-like receptor Pathway","24142728","no","no","","","","","","","","","","","","","There only seemed to be an effect on TLR by progesterone",""
+"Progesterone-mediated oocyte maturation","Toll-like receptor signaling pathway","Progesterone Toll-like receptor Pathway","26083048","no","no","","","","","","","","","","","","","The full text was not available through PubMed or the library, most likely because it was published only very recently, June 17, 2015. The abstract though seems to suggest that the pathways interact somehow, but more information is needed",""
+"Toll-like receptor signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Toll-like receptor Pathway","26083048","no","no","","","","","","","","","","","","","The full text was not available through PubMed or the library, most likely because it was published only very recently, June 17, 2015. The abstract though seems to suggest that the pathways interact somehow, but more information is needed",""
+"Progesterone-mediated oocyte maturation","Toll-like receptor signaling pathway","Progesterone Toll-like receptor Pathway","19336472","no","no","","","","","","","","","","","","","The full text was not read because progesterone was only mentioned once in the abstract and it only mentioned progesterone synthesis, not that progesterone interacts with anything",""
+"Toll-like receptor signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Toll-like receptor Pathway","19336472","no","no","","","","","","","","","","","","","The full text was not read because progesterone was only mentioned once in the abstract and it only mentioned progesterone synthesis, not that progesterone interacts with anything",""
+"Progesterone-mediated oocyte maturation","Toll-like receptor signaling pathway","Progesterone Toll-like receptor Pathway","21518785","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentioned TLR once as being independent of the effect of estrogen and progesterone",""
+"Toll-like receptor signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Toll-like receptor Pathway","21518785","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentioned TLR once as being independent of the effect of estrogen and progesterone",""
+"Progesterone-mediated oocyte maturation","Toll-like receptor signaling pathway","Progesterone Toll-like receptor Pathway","23525700","yes","yes","inhibiting","progesterone","hormone","hormone","TLR7","Q9NYK1","UNIPROT","Homo sapiens","peripheral blood mononuclear cell","BTO:0001025","hepatitis C virus","This explains the more pronounced downregulation of TLR-7 expression upon co-stimulation with mifepristone and progesterone when compared to progesterone alone","The article does not explain the effect of progesterone on TLR7 very well, but it seems that progesterone downregulates the transcription of TLR7",""
+"Toll-like receptor signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Toll-like receptor Pathway","23525700","no","no","","","","","","","","","","","","","There only seemed to be an effect on TLR by progesterone",""
+"Progesterone-mediated oocyte maturation","Toll-like receptor signaling pathway","Progesterone Toll-like receptor Pathway","25242005","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only mentioned in the abstract to say that they respond to NP41, but not each other",""
+"Toll-like receptor signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Toll-like receptor Pathway","25242005","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only mentioned in the abstract to say that they respond to NP41, but not each other",""
+"Progesterone-mediated oocyte maturation","VEGF signaling pathway","Progesterone VEGF Crosstalk","24469992","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of progesterone in the abstract",""
+"VEGF signaling pathway","Progesterone-mediated oocyte maturation","Progesterone VEGF Crosstalk","24469992","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of progesterone in the abstract",""
+"Progesterone-mediated oocyte maturation","VEGF signaling pathway","Progesterone VEGF Cross-talk","23426970","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentioned each pathway interacting with caveolin-1, not each other",""
+"VEGF signaling pathway","Progesterone-mediated oocyte maturation","Progesterone VEGF Cross-talk","23426970","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentioned each pathway interacting with caveolin-1, not each other",""
+"Progesterone-mediated oocyte maturation","VEGF signaling pathway","Progesterone VEGF Cross-talk","10379879","yes","yes","activating","PGR","P06401","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","However, progesterone increases VEGF protein expression in a human breast cancer cell line, and this effect is blocked by RU-486, suggesting it is mediated by the progesterone receptor","There were not many details given, but it does seem that progesterone has a transcriptional effect on VEGF",""
+"VEGF signaling pathway","Progesterone-mediated oocyte maturation","Progesterone VEGF Cross-talk","10379879","no","no","","","","","","","","","","","","","There only seemed to be an effect on VEGF by progesterone",""
+"Progesterone-mediated oocyte maturation","VEGF signaling pathway","Progesterone VEGF Cross-talk","21110084","no","no","","","","","","","","","","","","","The full paper was not read because progesterone was not mentioned in the abstract",""
+"VEGF signaling pathway","Progesterone-mediated oocyte maturation","Progesterone VEGF Cross-talk","21110084","no","no","","","","","","","","","","","","","The full paper was not read because progesterone was not mentioned in the abstract",""
+"Progesterone-mediated oocyte maturation","VEGF signaling pathway","Progesterone VEGF Pathway","24045404","yes","yes","inhibiting","","","","","","","Rattus norvegicus","brain","BTO:0000142","stroke","Consistent with our previous findings in a permanent MCAO model, our results demonstrate that treatment with PROG significantly decreased the level of VEGF after stroke","Since no mechanism is provided, the crosstalk is unclear, but the text does say that treatment with progesterone decreases expression of VEGF",""
+"VEGF signaling pathway","Progesterone-mediated oocyte maturation","Progesterone VEGF Pathway","24045404","no","no","","","","","","","","","","","","","There only seemed to be an effect on VEGF by progesterone",""
+"Progesterone-mediated oocyte maturation","Wnt signaling pathway","Progesterone Wnt Crosstalk","25603931","yes","yes","activating","progesterone","hormone","hormone","Wnt4","P22724","UNIPROT","Mus musculus","many","","puberty","Progesterone induced Wnt4 mRNA expression in pubertal and adult organoids to 8.7‐ and 4.5‐fold, respectively","The text is very confusing about the effect that progesterone has on Wnt, but it seems to have a transcriptional inducing effect",""
+"Wnt signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Wnt Crosstalk","25603931","no","no","","","","","","","","","","","","","There only seemed to be an effect on Wnt by progesterone",""
+"Progesterone-mediated oocyte maturation","Wnt signaling pathway","Progesterone Wnt Crosstalk","21642474","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed interactions that Wnt has with estrogen, not progesterone",""
+"Wnt signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Wnt Crosstalk","21642474","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed interactions that Wnt has with estrogen, not progesterone",""
+"Progesterone-mediated oocyte maturation","Wnt signaling pathway","Progesterone Wnt Crosstalk","17021345","no","no","","","","","","","","","","","","","The full article was not read because both pathways were only briefly mentioned and both in a different context",""
+"Wnt signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Wnt Crosstalk","17021345","no","no","","","","","","","","","","","","","The full article was not read because both pathways were only briefly mentioned and both in a different context",""
+"Progesterone-mediated oocyte maturation","Wnt signaling pathway","Progesterone Wnt Crosstalk","15257551","no","no","","","","","","","","","","","","","The text mainly discusses how each pathway interacts with estrogen, and not each other",""
+"Wnt signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Wnt Crosstalk","15257551","no","no","","","","","","","","","","","","","The text mainly discusses how each pathway interacts with estrogen, and not each other",""
+"Progesterone-mediated oocyte maturation","Wnt signaling pathway","Progesterone Wnt Cross-talk","17609436","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not mention any potential interactions between the Wnt and progesterone",""
+"Wnt signaling pathway","Progesterone-mediated oocyte maturation","Progesterone Wnt Cross-talk","17609436","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not mention any potential interactions between the Wnt and progesterone",""
+"Thyroid hormone synthesis","mTOR signaling pathway","TSH mTOR Pathway","23898069","no","no","","","","","","","","","","","","","The full text was not read because TSH was only mentioned once and in a different context than mTOR",""
+"mTOR signaling pathway","Thyroid hormone synthesis","TSH mTOR Pathway","23898069","no","no","","","","","","","","","","","","","The full text was not read because TSH was only mentioned once and in a different context than mTOR",""
+"Thyroid hormone synthesis","mTOR signaling pathway","TSH mTOR Pathway","23707767","no","no","","","","","","","","","","","","","The full article was not read because TSH was not mentioned in the abstract",""
+"mTOR signaling pathway","Thyroid hormone synthesis","TSH mTOR Pathway","23707767","no","no","","","","","","","","","","","","","The full article was not read because TSH was not mentioned in the abstract",""
+"Thyroid hormone synthesis","mTOR signaling pathway","TSH mTOR Pathway","17804710","no","no","","","","","","","","","","","","","The text suggests that there is some kind of relationship/interaction between them, but it does not explain it well and it is too ambiguous",""
+"mTOR signaling pathway","Thyroid hormone synthesis","TSH mTOR Pathway","17804710","no","no","","","","","","","","","","","","","The text suggests that there is some kind of relationship/interaction between them, but it does not explain it well and it is too ambiguous",""
+"Thyroid hormone synthesis","mTOR signaling pathway","TSH mTOR Pathway","12668683","no","no","","","","","","","","","","","","","The text suggests a potential relationship between S6K1 and TSH, but they provide no solid evidence to say that they actually have a relationship",""
+"mTOR signaling pathway","Thyroid hormone synthesis","TSH mTOR Pathway","12668683","no","no","","","","","","","","","","","","","The text suggests a potential relationship between S6K1 and TSH, but they provide no solid evidence to say that they actually have a relationship",""
+"Thyroid hormone synthesis","mTOR signaling pathway","TSH mTOR Pathway","18356276","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were mentioned in a different context",""
+"mTOR signaling pathway","Thyroid hormone synthesis","TSH mTOR Pathway","18356276","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were mentioned in a different context",""
+"Thyroid hormone synthesis","Adipocytokine signaling pathway","TSH Leptin Cross-talk","24692351","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses how each is involved with the thyroid gland and does not mention them interacting with each other",""
+"Adipocytokine signaling pathway","Thyroid hormone synthesis","TSH Leptin Cross-talk","24692351","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses how each is involved with the thyroid gland and does not mention them interacting with each other",""
+"Thyroid hormone synthesis","Adipocytokine signaling pathway","TSH Leptin Cross-talk","11344208","no","no","","","","","","","","","","","","","The article suggested that there is a correlation between TSH and leptin, but there was no evidence of any interactions",""
+"Adipocytokine signaling pathway","Thyroid hormone synthesis","TSH Leptin Cross-talk","11344208","no","no","","","","","","","","","","","","","The article suggested that there is a correlation between TSH and leptin, but there was no evidence of any interactions",""
+"Thyroid hormone synthesis","Adipocytokine signaling pathway","TSH Leptin Pathway","22314332","no","no","","","","","","","","","","","","","The text only describes leptin affecting TSH secretion, and does not mention leptin actually interacting with TSH. The full text was not available through PubMed but was available through the library and has been requested",""
+"Adipocytokine signaling pathway","Thyroid hormone synthesis","TSH Leptin Pathway","22314332","no","no","","","","","","","","","","","","","The text only describes leptin affecting TSH secretion, and does not mention leptin actually interacting with TSH. The full text was not available through PubMed but was available through the library and has been requested",""
+"Thyroid hormone synthesis","Adipocytokine signaling pathway","TSH Leptin Pathway","22875962","no","no","","","","","","","","","","","","","The text again claimed a relationship between TSH and leptin, but there were not many details, although it seems that leptin has more of an effect on TSH secretion rather than the TSH pathway",""
+"Adipocytokine signaling pathway","Thyroid hormone synthesis","TSH Leptin Pathway","22875962","no","no","","","","","","","","","","","","","The text again claimed a relationship between TSH and leptin, but there were not many details, although it seems that leptin has more of an effect on TSH secretion rather than the TSH pathway",""
+"Thyroid hormone synthesis","Adipocytokine signaling pathway","TSH Leptin Pathway","25662278","yes","yes","inhibiting","","","","","","","Rattus norvegicus","adipocyte","BTO:0000443","normal","TSH decreased Lep mRNA in a concentration-dependent way (to 5% of basal values at 100 mU/ml) in both basal and T3-treated cells.","The text does not provide a lot of detail but it seems that TSH has an inhibitory effect on the transcription of leptin, but no mechanism is provided",""
+"Adipocytokine signaling pathway","Thyroid hormone synthesis","TSH Leptin Pathway","25662278","no","no","","","","","","","","","","","","","There only seemed to be an effect on leptin by TSH",""
+"Thyroid hormone synthesis","ErbB signaling pathway","TSH ErbB Pathway","7903543","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that TSH had no effect in the study being talked about",""
+"ErbB signaling pathway","Thyroid hormone synthesis","TSH ErbB Pathway","7903543","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that TSH had no effect in the study being talked about",""
+"Thyroid hormone synthesis","ErbB signaling pathway","TSH EGFR Pathway","22007939","no","no","","","","","","","","","","","","","The full text was not read because the abstract mentions EGFR acting independently of TSH",""
+"ErbB signaling pathway","Thyroid hormone synthesis","TSH EGFR Pathway","22007939","no","no","","","","","","","","","","","","","The full text was not read because the abstract mentions EGFR acting independently of TSH",""
+"Thyroid hormone synthesis","ErbB signaling pathway","TSH EGFR Pathway","18445595","no","no","","","","","","","","","","","","","The full paper was not read because the abstract mainly discusses the relationship between TSH and MAPK, and only mentions that EGFR is not involved with MAPK",""
+"ErbB signaling pathway","Thyroid hormone synthesis","TSH EGFR Pathway","18445595","no","no","","","","","","","","","","","","","The full paper was not read because the abstract mainly discusses the relationship between TSH and MAPK, and only mentions that EGFR is not involved with MAPK",""
+"Thyroid hormone synthesis","ErbB signaling pathway","TG ErbB Crosstalk","16930573","no","no","","","","","","","","","","","","","Only the abstract was read because TG referred to transgenic, not thyroglobulin",""
+"ErbB signaling pathway","Thyroid hormone synthesis","TG ErbB Crosstalk","16930573","no","no","","","","","","","","","","","","","Only the abstract was read because TG referred to transgenic, not thyroglobulin",""
+"Thyroid hormone synthesis","ErbB signaling pathway","TG ErbB Pathway","24980976","no","no","","","","","","","","","","","","","Only the abstract was read because TG referred to transgenic, not thyroglobulin",""
+"ErbB signaling pathway","Thyroid hormone synthesis","TG ErbB Pathway","24980976","no","no","","","","","","","","","","","","","Only the abstract was read because TG referred to transgenic, not thyroglobulin",""
+"Thyroid hormone synthesis","Estrogen signaling pathway","TSH Estrogen Crosstalk","21684237","no","no","","","","","","","","","","","","","The full text was not read because estrogen was not mentioned in the abstract",""
+"Estrogen signaling pathway","Thyroid hormone synthesis","TSH Estrogen Crosstalk","21684237","no","no","","","","","","","","","","","","","The full text was not read because estrogen was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Estrogen signaling pathway","TSH Estrogen Crosstalk","4210021","no","no","","","","","","","","","","","","","The text mostly discussed the effect estrogen has on the release of TSH, but does not mention TSH and estrogen interacting. The full text was not available through PubMed but was available through the library and has been requested",""
+"Estrogen signaling pathway","Thyroid hormone synthesis","TSH Estrogen Crosstalk","4210021","no","no","","","","","","","","","","","","","The text mostly discussed the effect estrogen has on the release of TSH, but does not mention TSH and estrogen interacting. The full text was not available through PubMed but was available through the library and has been requested",""
+"Thyroid hormone synthesis","Estrogen signaling pathway","TSH Estrogen Crosstalk","696176","no","no","","","","","","","","","","","","","The full text was not read because estrogen was not mentioned in the abstract",""
+"Estrogen signaling pathway","Thyroid hormone synthesis","TSH Estrogen Crosstalk","696176","no","no","","","","","","","","","","","","","The full text was not read because estrogen was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Estrogen signaling pathway","TSH Estrogen Cross-talk","7867556","no","no","","","","","","","","","","","","","The text mainly discusses crosstalk between T3 receptor and estrogen receptor, and T3 receptor is not part of the TSH pathway. The full text was not available through PubMed but was available through the library and has been requested",""
+"Estrogen signaling pathway","Thyroid hormone synthesis","TSH Estrogen Cross-talk","7867556","no","no","","","","","","","","","","","","","The text mainly discusses crosstalk between T3 receptor and estrogen receptor, and T3 receptor is not part of the TSH pathway. The full text was not available through PubMed but was available through the library and has been requested",""
+"Thyroid hormone synthesis","Estrogen signaling pathway","TSH Estrogen Cross-talk","12163847","no","no","","","","","","","","","","","","","The full article was not read because estrogen and TSH were both only mentioned as being part of different cancers, and there was no suggestion of any potential interaction between them in the abstract",""
+"Estrogen signaling pathway","Thyroid hormone synthesis","TSH Estrogen Cross-talk","12163847","no","no","","","","","","","","","","","","","The full article was not read because estrogen and TSH were both only mentioned as being part of different cancers, and there was no suggestion of any potential interaction between them in the abstract",""
+"Thyroid hormone synthesis","GnRH signaling pathway","TSH GnRH Crosstalk","26050562","no","no","","","","","","","","","","","","","The full text was not read because GnRH was only mentioned to have a relationship with TH, not TSH in the abstract",""
+"GnRH signaling pathway","Thyroid hormone synthesis","TSH GnRH Crosstalk","26050562","no","no","","","","","","","","","","","","","The full text was not read because GnRH was only mentioned to have a relationship with TH, not TSH in the abstract",""
+"Thyroid hormone synthesis","GnRH signaling pathway","TSH GnRH Crosstalk","2492922","no","no","","","","","","","","","","","","","The full article was not read because there is no mention of GnRH in the abstract",""
+"GnRH signaling pathway","Thyroid hormone synthesis","TSH GnRH Crosstalk","2492922","no","no","","","","","","","","","","","","","The full article was not read because there is no mention of GnRH in the abstract",""
+"Thyroid hormone synthesis","GnRH signaling pathway","TSH GnRH Crosstalk","9405122","no","no","","","","","","","","","","","","","The full paper was not read because in the abstract GnRH is only mentioned to say that its agonist did not change plasma TSH",""
+"GnRH signaling pathway","Thyroid hormone synthesis","TSH GnRH Crosstalk","9405122","no","no","","","","","","","","","","","","","The full paper was not read because in the abstract GnRH is only mentioned to say that its agonist did not change plasma TSH",""
+"Thyroid hormone synthesis","GnRH signaling pathway","TSH GnRH Crosstalk","813988","no","no","","","","","","","","","","","","","The full article was not read because there is no mention of GnRH in the abstract",""
+"GnRH signaling pathway","Thyroid hormone synthesis","TSH GnRH Crosstalk","813988","no","no","","","","","","","","","","","","","The full article was not read because there is no mention of GnRH in the abstract",""
+"Thyroid hormone synthesis","GnRH signaling pathway","TSH GnRH Crosstalk","788227","no","no","","","","","","","","","","","","","The full text was not read because TSH and GnRH were both not mentioned in the abstract",""
+"GnRH signaling pathway","Thyroid hormone synthesis","TSH GnRH Crosstalk","788227","no","no","","","","","","","","","","","","","The full text was not read because TSH and GnRH were both not mentioned in the abstract",""
+"Thyroid hormone synthesis","HIF-1 signaling pathway","TSH HIF-1 Pathway","25406019","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that HIF-1alpha acts indepently of TSH",""
+"HIF-1 signaling pathway","Thyroid hormone synthesis","TSH HIF-1 Pathway","25406019","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that HIF-1alpha acts indepently of TSH",""
+"Thyroid hormone synthesis","HIF-1 signaling pathway","TSH HIF-1 Pathway","19558833","no","no","","","","","","","","","","","","","The full text was not read because both were only mentioned to have an effect on papillary thyroid carcinome. HIF-1 was mentioned to have correlated expression with other things, but not TSH. The abstract also suggests that if they do have a relationship, it is most likely indirect",""
+"HIF-1 signaling pathway","Thyroid hormone synthesis","TSH HIF-1 Pathway","19558833","no","no","","","","","","","","","","","","","The full text was not read because both were only mentioned to have an effect on papillary thyroid carcinome. HIF-1 was mentioned to have correlated expression with other things, but not TSH. The abstract also suggests that if they do have a relationship, it is most likely indirect",""
+"Thyroid hormone synthesis","HIF-1 signaling pathway","TSH HIF-1 Pathway","19336661","no","no","","","","","","","","","","","","","The text mainly discusses HIF-1 and VEGF, and states that the study being performed is independent of TSH",""
+"HIF-1 signaling pathway","Thyroid hormone synthesis","TSH HIF-1 Pathway","19336661","no","no","","","","","","","","","","","","","The text mainly discusses HIF-1 and VEGF, and states that the study being performed is independent of TSH",""
+"Thyroid hormone synthesis","HIF-1 signaling pathway","T3 HIF-1 Pathway","20100314","no","no","","","","","","","","","","","","","The text suggests that T3 has some kind of transcriptional effect on HIF-1alpha. but it does not provide any details or give any conclusive evidence",""
+"HIF-1 signaling pathway","Thyroid hormone synthesis","T3 HIF-1 Pathway","20100314","no","no","","","","","","","","","","","","","The text suggests that T3 has some kind of transcriptional effect on HIF-1alpha. but it does not provide any details or give any conclusive evidence",""
+"Thyroid hormone synthesis","HIF-1 signaling pathway","T3 HIF-1 Pathway","18259611","no","no","","","","","","","","","","","","","The full paper was not read because the abstract suggests an effect on T3 by HIF-1, but the abstract explains that it is not direct",""
+"HIF-1 signaling pathway","Thyroid hormone synthesis","T3 HIF-1 Pathway","18259611","no","no","","","","","","","","","","","","","The full paper was not read because the abstract suggests an effect on T3 by HIF-1, but the abstract explains that it is not direct",""
+"Thyroid hormone synthesis","Hippo signaling pathway","TSH Hippo Pathway","21311569","no","no","","","","","","","","","","","","","The full text was not read because Tsh in the abstract meant Teashirt protein, not thyroid stimulating hormone",""
+"Hippo signaling pathway","Thyroid hormone synthesis","TSH Hippo Pathway","21311569","no","no","","","","","","","","","","","","","The full text was not read because Tsh in the abstract meant Teashirt protein, not thyroid stimulating hormone",""
+"Thyroid hormone synthesis","Hippo signaling pathway","TSH Hippo Pathway","19762509","no","no","","","","","","","","","","","","","The full text was not read because Tsh in the abstract meant Teashirt protein, not thyroid stimulating hormone",""
+"Hippo signaling pathway","Thyroid hormone synthesis","TSH Hippo Pathway","19762509","no","no","","","","","","","","","","","","","The full text was not read because Tsh in the abstract meant Teashirt protein, not thyroid stimulating hormone",""
+"Thyroid hormone synthesis","Hippo signaling pathway","TG Hippo Pathway","25484190","no","no","","","","","","","","","","","","","The full article was not read because neither pathway was mentioned in the abstract",""
+"Hippo signaling pathway","Thyroid hormone synthesis","TG Hippo Pathway","25484190","no","no","","","","","","","","","","","","","The full article was not read because neither pathway was mentioned in the abstract",""
+"Thyroid hormone synthesis","Hippo signaling pathway","TG Hippo Pathway","26157348","no","no","","","","","","","","","","","","","The full paper was not read because Tg in the abstract means transgenic, not thyroglobulin",""
+"Hippo signaling pathway","Thyroid hormone synthesis","TG Hippo Pathway","26157348","no","no","","","","","","","","","","","","","The full paper was not read because Tg in the abstract means transgenic, not thyroglobulin",""
+"Thyroid hormone synthesis","Hippo signaling pathway","TG Hippo Pathway","19956688","no","no","","","","","","","","","","","","","The full paper was not read because Tg in the abstract means transgenic, not thyroglobulin",""
+"Hippo signaling pathway","Thyroid hormone synthesis","TG Hippo Pathway","19956688","no","no","","","","","","","","","","","","","The full paper was not read because Tg in the abstract means transgenic, not thyroglobulin",""
+"Thyroid hormone synthesis","Insulin signaling pathway","TSH Insulin Crosstalk","808409","no","no","","","","","","","","","","","","","The text suggests a relationship between insulin and the release of T3, but the text does not explain or give any details as to how that happens, so the text is too ambiguous to determine crosstalk. The full text was not available through PubMed, but was available through the library and has been saved",""
+"Insulin signaling pathway","Thyroid hormone synthesis","TSH Insulin Crosstalk","808409","no","no","","","","","","","","","","","","","The text suggests a relationship between insulin and the release of T3, but the text does not explain or give any details as to how that happens, so the text is too ambiguous to determine crosstalk. The full text was not available through PubMed, but was available through the library and has been saved",""
+"Thyroid hormone synthesis","Insulin signaling pathway","TSH Insulin Crosstalk","6233131","no","no","","","","","","","","","","","","","The full text was not read because insulin was only mentioned once in the abstract and in a different context than TSH",""
+"Insulin signaling pathway","Thyroid hormone synthesis","TSH Insulin Crosstalk","6233131","no","no","","","","","","","","","","","","","The full text was not read because insulin was only mentioned once in the abstract and in a different context than TSH",""
+"Thyroid hormone synthesis","Insulin signaling pathway","TSH Insulin Crosstalk","1261504","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that there was negligible cross-reactivity between TSH, insulin, and other hormones",""
+"Insulin signaling pathway","Thyroid hormone synthesis","TSH Insulin Crosstalk","1261504","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that there was negligible cross-reactivity between TSH, insulin, and other hormones",""
+"Thyroid hormone synthesis","Insulin signaling pathway","TSH Insulin Crosstalk","9924986","no","no","","","","","","","","","","","","","The text mentions that mitogenic effects of TSH need the presence of insulin, but does not go into any detail or provide any evidence/interactions",""
+"Insulin signaling pathway","Thyroid hormone synthesis","TSH Insulin Crosstalk","9924986","no","no","","","","","","","","","","","","","The text mentions that mitogenic effects of TSH need the presence of insulin, but does not go into any detail or provide any evidence/interactions",""
+"Thyroid hormone synthesis","Insulin signaling pathway","TSH Insulin Cross-talk","25485727","no","no","","","","","","","","","","","","","The text claims that there is bidirectional crosstalk between TSH and IGF-1, but it does not give good evidence and does not describe any interactions between the actual pathways. The full text was not available through PubMed, but was available through the library and has been saved",""
+"Insulin signaling pathway","Thyroid hormone synthesis","TSH Insulin Cross-talk","25485727","no","no","","","","","","","","","","","","","The text claims that there is bidirectional crosstalk between TSH and IGF-1, but it does not give good evidence and does not describe any interactions between the actual pathways. The full text was not available through PubMed, but was available through the library and has been saved",""
+"Thyroid hormone synthesis","Jak-STAT signaling pathway","TSH Jak-STAT Pathway","10809230","yes","no","activating","Tshr","P21463","UNIPROT","Jak2:Stat3","Q62689:P52631","UNIPROT","Rattus norvegicus","thyroid gland","BTO:0001379","normal","These findings suggest that TSHR might have a unique unidentified binding site for JAK2 or the existence of adaptor molecules that mediate the binding between JAK2 and TSHR","The text states many times that there are direct interactions between Jak-STAT and TSHR. It states that TSHR binds directly to Jak2 (although maybe with the help of mediators). It also suggests later that TSH phosphorylates STAT3, although the article is unclear about whether that is direct or only a result of activating Jak",""
+"Thyroid hormone synthesis","Jak-STAT signaling pathway","TSH Jak-STAT Pathway","10809230","yes","no","activating","Tshr","P21463","UNIPROT","Jak2:Stat3","Q62689:P52631","UNIPROT","Rattus norvegicus","ovary","BTO:0000975","normal","These findings suggest that TSHR might have a unique unidentified binding site for JAK2 or the existence of adaptor molecules that mediate the binding between JAK2 and TSHR","The text states many times that there are direct interactions between Jak-STAT and TSHR. It states that TSHR binds directly to Jak2 (although maybe with the help of mediators). It also suggests later that TSH phosphorylates STAT3, although the article is unclear about whether that is direct or only a result of activating Jak",""
+"Jak-STAT signaling pathway","Thyroid hormone synthesis","TSH Jak-STAT Pathway","10809230","no","no","","","","","","","","","","","","","There only seemed to be an effect on Jak-STAT by TSH",""
+"Thyroid hormone synthesis","Jak-STAT signaling pathway","TSH Jak-STAT Pathway","12242030","no","no","","","","","","","","","","","","","The text mainly discusses that TSH activates STAT3 by activating the phosphorylation of STAT3, but the text does not specifically say that a member of the TSH pathway phosphorylates STAT3, and the article also suggests some mediators for the activation of STAT3, so the text is too ambiguous to determine crosstalk",""
+"Jak-STAT signaling pathway","Thyroid hormone synthesis","TSH Jak-STAT Pathway","12242030","no","no","","","","","","","","","","","","","The text mainly discusses that TSH activates STAT3 by activating the phosphorylation of STAT3, but the text does not specifically say that a member of the TSH pathway phosphorylates STAT3, and the article also suggests some mediators for the activation of STAT3, so the text is too ambiguous to determine crosstalk",""
+"Thyroid hormone synthesis","Jak-STAT signaling pathway","TSH Jak-STAT Pathway","10830295","yes","no","inhibiting","Cga","P11962","UNIPROT","Jak1","G3V9W2","UNIPROT","Rattus norvegicus","thyroid gland","BTO:0001379","normal","These findings suggest that the inhibitory effect generated by TSH is specifically based on the inhibition of Jak1, which is associated with the cytoplasmic domain of IFNγ receptor α","The text states that TSH inhibits the phorphorylation of Jak1, which is what causes the seen inhibition of STAT1 as well, and there is no indication that the effect is indirect, although the mechanism is not completely clear",""
+"Jak-STAT signaling pathway","Thyroid hormone synthesis","TSH Jak-STAT Pathway","10830295","no","no","","","","","","","","","","","","","There only seemed to be an effect on Jak-STAT by TSH",""
+"Thyroid hormone synthesis","Jak-STAT signaling pathway","TSH Jak-STAT Pathway","15662590","yes","yes","activating","CGA","P01215","UNIPROT","STAT5A","P42229","UNIPROT","Homo sapiens","hypophysis","BTO:0001073","normal","However, instead of signalling through STAT3, TSH results in upresgualtion of STAT5a gene transcripts","Although not a lot of detail provided, the text does say that TSH upregulates transcription of STAT5a. The full text was not available through PubMed, but was available through the library and has been saved",""
+"Jak-STAT signaling pathway","Thyroid hormone synthesis","TSH Jak-STAT Pathway","15662590","no","no","","","","","","","","","","","","","There only seemed to be an effect on Jak-STAT by TSH. The full text was not available through PubMed, but was available through the library and has been saved",""
+"Thyroid hormone synthesis","Jak-STAT signaling pathway","TSH Jak-STAT Pathway","17154079","no","no","","","","","","","","","","","","","The full text was not available through PubMed or the library, and could not be read any since it is written in Japanese",""
+"Jak-STAT signaling pathway","Thyroid hormone synthesis","TSH Jak-STAT Pathway","17154079","no","no","","","","","","","","","","","","","The full text was not available through PubMed or the library, and could not be read any since it is written in Japanese",""
+"Thyroid hormone synthesis","Jak-STAT signaling pathway","TSH Jak-STAT Pathway","16423818","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Jak-STAT signaling pathway","Thyroid hormone synthesis","TSH Jak-STAT Pathway","16423818","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Thyroid hormone synthesis","MAPK signaling pathway","TSH MAPK Cross-talk","9632754","yes","no","inhibiting","Prkaca","P27791","UNIPROT","[Hras/Kras]","[P20171/P08644]","UNIPROT","Rattus norvegicus","thyroid gland","BTO:0001379","normal","These results suggest that growth rates in TSH may reflect the affinities of these proteins (Ras proteins) for Raf-1, an interaction which is inhibited by PKA","The text is very confusing about the relationship between MAPK and TSH, but it does seem that PKA inhibits Ras from being able to bind to Raf. The text also mentions other interactions, but this is the only clear definitive one",""
+"MAPK signaling pathway","Thyroid hormone synthesis","TSH MAPK Cross-talk","9632754","no","no","","","","","","","","","","","","","The text mentions that crosstalk between Ras and PKA is bidirectional, but does not explain clearly at all or give any examples of crosstalk from Ras to PKA",""
+"Thyroid hormone synthesis","MAPK signaling pathway","TSH MAPK Pathway","22445893","yes","no","activating","Tg","P06882","UNIPROT","Raf1,Map2k1/Map2k2,Mapk3/Mapk1","P11345,Q01986/P36506,P21708/P63086","UNIPROT","Rattus norvegicus","thyroid gland","BTO:0001379","normal","The c-Raf/MEK/ERK pathway is essential for cell proliferation and our results indicate that Tg increased the phosphorylation of c-Raf, MEK1/2 and ERK1/2 thereby suggesting that Tg utilizes the c-Raf/MEK/ERK pathway to induce thyroid cell proliferation","The text is confusing when it explains the effect that Tg has on MAPK, but it does explain that Tg increases the phosphorylation of many MAPK components, and there is no suggestion that it is not direct",""
+"MAPK signaling pathway","Thyroid hormone synthesis","TSH MAPK Pathway","22445893","no","no","","","","","","","","","","","","","There only seemed to be an effect on MAPK by Tg",""
+"Thyroid hormone synthesis","MAPK signaling pathway","TSH MAPK Pathway","26146959","no","no","","","","","","","","","","","","","The text mainly focuses on the interactions with TSH and PI3K. The text suggests a relationship between MAPK and TSH but does not explain it well and it is too ambiguous",""
+"MAPK signaling pathway","Thyroid hormone synthesis","TSH MAPK Pathway","26146959","no","no","","","","","","","","","","","","","The text mainly focuses on the interactions with TSH and PI3K. The text suggests a relationship between MAPK and TSH but does not explain it well and it is too ambiguous",""
+"Thyroid hormone synthesis","MAPK signaling pathway","TSH MAPK Pathway","23969277","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context",""
+"MAPK signaling pathway","Thyroid hormone synthesis","TSH MAPK Pathway","23969277","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context",""
+"Thyroid hormone synthesis","MAPK signaling pathway","TSH MAPK Pathway","22301787","no","no","","","","","","","","","","","","","The text suggests an effect on MAPK by TSH, but it is too ambiguous",""
+"MAPK signaling pathway","Thyroid hormone synthesis","TSH MAPK Pathway","22301787","no","no","","","","","","","","","","","","","The text suggests an effect on MAPK by TSH, but it is too ambiguous",""
+"Thyroid hormone synthesis","Neurotrophin signaling pathway","TSH NGF Pathway","23735822","no","no","","","","","","","","","","","","","The full text was not read because in the abstract both pathways were only mentioned as being affected by depression",""
+"Neurotrophin signaling pathway","Thyroid hormone synthesis","TSH NGF Pathway","23735822","no","no","","","","","","","","","","","","","The full text was not read because in the abstract both pathways were only mentioned as being affected by depression",""
+"Thyroid hormone synthesis","Neurotrophin signaling pathway","TSH NGF Pathway","9685657","yes","yes","activating","CGA","Q9XSW8","UNIPROT","NR4A1","P51666","UNIPROT","Canis familiaris","thyroid gland","BTO:0001379","normal","Our results show that TSH upregulates NGFI-B mRNA expression, to a similar extent either in the presence or the absence of insulin.","The text explains a clear transcriptional effect on NGFI-B by TSH",""
+"Neurotrophin signaling pathway","Thyroid hormone synthesis","TSH NGF Pathway","9685657","no","no","","","","","","","","","","","","","There only seemed to be an effect on NGF by TSH",""
+"Thyroid hormone synthesis","Neurotrophin signaling pathway","T3 Neurotrophin Pathway","20231820","no","no","","","","","","","","","","","","","The text suggests that T3 and T4 increase the expression of NTR, but it is explained that it is through a mechanism that is not part of the TSH pathway",""
+"Neurotrophin signaling pathway","Thyroid hormone synthesis","T3 Neurotrophin Pathway","20231820","no","no","","","","","","","","","","","","","The text suggests that T3 and T4 increase the expression of NTR, but it is explained that it is through a mechanism that is not part of the TSH pathway",""
+"Thyroid hormone synthesis","Neurotrophin signaling pathway","TG Neurotrophin Pathway","22396883","no","no","","","","","","","","","","","","","The full text was not read because in the abstract TG means transgenic",""
+"Neurotrophin signaling pathway","Thyroid hormone synthesis","TG Neurotrophin Pathway","22396883","no","no","","","","","","","","","","","","","The full text was not read because in the abstract TG means transgenic",""
+"Thyroid hormone synthesis","Neurotrophin signaling pathway","TG Neurotrophin Pathway","15246692","no","no","","","","","","","","","","","","","The full article was not read because in the abstract TG stands for trigeminal ganglion",""
+"Neurotrophin signaling pathway","Thyroid hormone synthesis","TG Neurotrophin Pathway","15246692","no","no","","","","","","","","","","","","","The full article was not read because in the abstract TG stands for trigeminal ganglion",""
+"Thyroid hormone synthesis","NF-kappa B signaling pathway","TSH NF-kappa B Pathway","23864495","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentions how each interacts with TNF not each other",""
+"NF-kappa B signaling pathway","Thyroid hormone synthesis","TSH NF-kappa B Pathway","23864495","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentions how each interacts with TNF not each other",""
+"Thyroid hormone synthesis","NF-kappa B signaling pathway","TSH NF-kappa B Pathway","18308843","yes","no","activating","TSHR","P16473","UNIPROT","IKBKB","O14920","UNIPROT","Homo sapiens","adipocyte","BTO:0000443","normal","TSH treatment clearly augmented IKKβ phosphorylation and IL-6 mRNA expression in a TSHR-specific fashion.","The text is not completely clear on the mechanism by which TSH activates NF-kB, but the effect is not transcriptional and it seems to be direct",""
+"NF-kappa B signaling pathway","Thyroid hormone synthesis","TSH NF-kappa B Pathway","18308843","no","no","","","","","","","","","","","","","There only seemed to be an effect on NF-kB by TSH",""
+"Thyroid hormone synthesis","NF-kappa B signaling pathway","Thyroglobulin NF-kappa B Pathway","12021180","no","no","","","","","","","","","","","","","The text only mentions how both react to an alteration in the endoplasmic reticulum",""
+"NF-kappa B signaling pathway","Thyroid hormone synthesis","Thyroglobulin NF-kappa B Pathway","12021180","no","no","","","","","","","","","","","","","The text only mentions how both react to an alteration in the endoplasmic reticulum",""
+"Thyroid hormone synthesis","NF-kappa B signaling pathway","TSH IKK Pathway","24661543","no","no","","","","","","","","","","","","","The text seems to suggest that TSH has some effect on the phosphorylation of IKKbeta, but it provides no details or mechanisms, so the crosstalk is too ambiguous",""
+"NF-kappa B signaling pathway","Thyroid hormone synthesis","TSH IKK Pathway","24661543","no","no","","","","","","","","","","","","","The text seems to suggest that TSH has some effect on the phosphorylation of IKKbeta, but it provides no details or mechanisms, so the crosstalk is too ambiguous",""
+"Thyroid hormone synthesis","NF-kappa B signaling pathway","TG NF-kappa B Pathway","24746137","no","no","","","","","","","","","","","","","The full article was not read because in the abstract Tg means thapsigargin, not thyroglobulin",""
+"NF-kappa B signaling pathway","Thyroid hormone synthesis","TG NF-kappa B Pathway","24746137","no","no","","","","","","","","","","","","","The full article was not read because in the abstract Tg means thapsigargin, not thyroglobulin",""
+"Thyroid hormone synthesis","Prolactin signaling pathway","TSH Prolactin Crosstalk","772521","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that there is no cross reaction with TSH",""
+"Prolactin signaling pathway","Thyroid hormone synthesis","TSH Prolactin Crosstalk","772521","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that there is no cross reaction with TSH",""
+"Thyroid hormone synthesis","Prolactin signaling pathway","TSH Prolactin Crosstalk","4210021","no","no","","","","","","","","","","","","","The full article was not read because the abstract mainly discusses the effect of estrogen on prolactin and TRH, and doesn't mention any interactions with TSH. The abstract and the full text were both unavailable through PubMed, but were available through the library and have been saved",""
+"Prolactin signaling pathway","Thyroid hormone synthesis","TSH Prolactin Crosstalk","4210021","no","no","","","","","","","","","","","","","The full article was not read because the abstract mainly discusses the effect of estrogen on prolactin and TRH, and doesn't mention any interactions with TSH. The abstract and the full text were both unavailable through PubMed, but were available through the library and have been saved",""
+"Thyroid hormone synthesis","Prolactin signaling pathway","TSH Prolactin Crosstalk","696176","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that there is no cross reaction with TSH",""
+"Prolactin signaling pathway","Thyroid hormone synthesis","TSH Prolactin Crosstalk","696176","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that there is no cross reaction with TSH",""
+"Thyroid hormone synthesis","Prolactin signaling pathway","TSH Prolactin Crosstalk","2982978","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned TSH to say that it did not interact with prolactin",""
+"Prolactin signaling pathway","Thyroid hormone synthesis","TSH Prolactin Crosstalk","2982978","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned TSH to say that it did not interact with prolactin",""
+"Thyroid hormone synthesis","Prolactin signaling pathway","TSH Prolactin Crosstalk","1261504","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned TSH to say that it did not interact with prolactin",""
+"Prolactin signaling pathway","Thyroid hormone synthesis","TSH Prolactin Crosstalk","1261504","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned TSH to say that it did not interact with prolactin",""
+"Thyroid hormone synthesis","TGF-beta signaling pathway","TSH TGF-beta Pathway","23591524","no","no","","","","","","","","","","","","","There only seemed to be an effect on TSH pathway by Smad",""
+"TGF-beta signaling pathway","Thyroid hormone synthesis","TSH TGF-beta Pathway","23591524","yes","no","activating","SMAD3:SMAD4","P84022:Q13485","UNIPROT","PRKACA","P17612","UNIPROT","Homo sapiens","thyroid gland","BTO:0001379","cancer","It has been demonstrated that the P-Smad3/Smad4 complex interacts with and activates the PKA, resulting in CREB phosphorylation and activation of downstream target genes","The text states that the Smad3/4 complex binds to PKA to activate it so that it phosphorylates CREB",""
+"Thyroid hormone synthesis","TGF-beta signaling pathway","TSH TGF-beta Pathway","23969277","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentions TSH interacting with MAPK",""
+"TGF-beta signaling pathway","Thyroid hormone synthesis","TSH TGF-beta Pathway","23969277","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentions TSH interacting with MAPK",""
+"Thyroid hormone synthesis","TGF-beta signaling pathway","TSH TGF-beta Pathway","10712520","no","no","","","","","","","","","","","","","The text suggests that there is a relationship between TGF-beta and TSH, but the text only describes indirect relationships, such as TSH will induce something and then TGF-beta will counteract the effects of that induction",""
+"TGF-beta signaling pathway","Thyroid hormone synthesis","TSH TGF-beta Pathway","10712520","no","no","","","","","","","","","","","","","The text suggests that there is a relationship between TGF-beta and TSH, but the text only describes indirect relationships, such as TSH will induce something and then TGF-beta will counteract the effects of that induction",""
+"Thyroid hormone synthesis","TGF-beta signaling pathway","TSH TGF-beta Pathway","9449644","no","no","","","","","","","","","","","","","There only seemed to be an effect on TSH pathway by Smad",""
+"TGF-beta signaling pathway","Thyroid hormone synthesis","TSH TGF-beta Pathway","9449644","yes","no","inhibiting","Tgfb1","P17246","UNIPROT","Slc5a5","Q63008","UNIPROT","Rattus norvegicus","thyroid gland","BTO:0001379","normal","TGF-β1 potently suppresses Na+/K+-ATPase expression and activity in young FRTL-5 cells and, as shown here, also suppresses NIS mRNA","The text states that TGF-beta suppresses the expression and activity of the sodium/potassium-ATPase, and suppresses NIS mRNA",""
+"TGF-beta signaling pathway","Thyroid hormone synthesis","TSH TGF-beta Pathway","9449644","no","unknown","unknown","Tgfb1","P17246","UNIPROT","Na+/K+ATPase/NIS","Other","Other","Rattus norvegicus","thyroid gland","BTO:0001379","normal","TGF-β1 potently suppresses Na+/K+-ATPase expression and activity in young FRTL-5 cells and, as shown here, also suppresses NIS mRNA","The text states that TGF-beta suppresses the expression and activity of the sodium/potassium-ATPase, and suppresses NIS mRNA **Sarah edit: Na+/K+-ATPase connection unclear; changed other entry to NIS (SLC5A5) and changing this entry to no crosstalk since we cannot delete entries.",""
+"Thyroid hormone synthesis","TGF-beta signaling pathway","TSH TGF-beta Pathway","22730517","no","no","","","","","","","","","","","","","The text did not mention any interaction between TGF-beta and TSH",""
+"TGF-beta signaling pathway","Thyroid hormone synthesis","TSH TGF-beta Pathway","22730517","no","no","","","","","","","","","","","","","The text did not mention any interaction between TGF-beta and TSH",""
+"Thyroid hormone synthesis","TNF signaling pathway","TSH TNF Pathway","24446657","no","no","","","","","","","","","","","","","The text suggests a potential relationship but only mentions it briefly and gives no details",""
+"TNF signaling pathway","Thyroid hormone synthesis","TSH TNF Pathway","24446657","no","no","","","","","","","","","","","","","The text suggests a potential relationship but only mentions it briefly and gives no details",""
+"Thyroid hormone synthesis","TNF signaling pathway","TSH TNF Pathway","23864495","no","no","","","","","","","","","","","","","The text mainly discusses how TSH affects TNF-alpha secretion, but does not say that they interact at all. The full text was not available through PubMed but was available through the library and has been saved",""
+"TNF signaling pathway","Thyroid hormone synthesis","TSH TNF Pathway","23864495","no","no","","","","","","","","","","","","","The text mainly discusses how TSH affects TNF-alpha secretion, but does not say that they interact at all. The full text was not available through PubMed but was available through the library and has been saved",""
+"Thyroid hormone synthesis","TNF signaling pathway","TSH TNF Pathway","9316456","no","no","","","","","","","","","","","","","The text only describes an indirect relationship between TSH and TNF. The full text was not available through PubMed but was available through the library and has been saved",""
+"TNF signaling pathway","Thyroid hormone synthesis","TSH TNF Pathway","9316456","no","no","","","","","","","","","","","","","The text only describes an indirect relationship between TSH and TNF. The full text was not available through PubMed but was available through the library and has been saved",""
+"Thyroid hormone synthesis","TNF signaling pathway","TSH TNF Pathway","12393601","no","no","","","","","","","","","","","","","The article mainly discussed how TSH has an effect on TNFalpha secretion, but does not mention that they actually interact",""
+"TNF signaling pathway","Thyroid hormone synthesis","TSH TNF Pathway","12393601","no","no","","","","","","","","","","","","","The article mainly discussed how TSH has an effect on TNFalpha secretion, but does not mention that they actually interact",""
+"Thyroid hormone synthesis","TNF signaling pathway","TSH TNF Pathway","23735822","no","no","","","","","","","","","","","","","The full article was not read because there was only brief mention of TNF in th abstract and it was in a different context than TSH",""
+"TNF signaling pathway","Thyroid hormone synthesis","TSH TNF Pathway","23735822","no","no","","","","","","","","","","","","","The full article was not read because there was only brief mention of TNF in th abstract and it was in a different context than TSH",""
+"Thyroid hormone synthesis","Toll-like receptor signaling pathway","TSH Toll-like receptor Pathway","23735822","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentioned both pathways and their potential relationships with depression, but they were not in the same context",""
+"Toll-like receptor signaling pathway","Thyroid hormone synthesis","TSH Toll-like receptor Pathway","23735822","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentioned both pathways and their potential relationships with depression, but they were not in the same context",""
+"Thyroid hormone synthesis","Toll-like receptor signaling pathway","T3 Toll-like receptor Pathway","19647301","no","no","","","","","","","","","","","","","The full article was not read because the T3 in the abstract means a stage T3, not the T3 from the TSH pathway",""
+"Toll-like receptor signaling pathway","Thyroid hormone synthesis","T3 Toll-like receptor Pathway","19647301","no","no","","","","","","","","","","","","","The full article was not read because the T3 in the abstract means a stage T3, not the T3 from the TSH pathway",""
+"Thyroid hormone synthesis","Toll-like receptor signaling pathway","T4 Toll-like receptor Pathway","21646247","no","no","","","","","","","","","","","","","The full paper was not read because in the abstract T4 means TLR4",""
+"Toll-like receptor signaling pathway","Thyroid hormone synthesis","T4 Toll-like receptor Pathway","21646247","no","no","","","","","","","","","","","","","The full paper was not read because in the abstract T4 means TLR5",""
+"Thyroid hormone synthesis","Toll-like receptor signaling pathway","TG Toll-like receptor Pathway","25245808","no","no","","","","","","","","","","","","","The full article was not read because TG in the abstract means thapsigargin",""
+"Toll-like receptor signaling pathway","Thyroid hormone synthesis","TG Toll-like receptor Pathway","25245808","no","no","","","","","","","","","","","","","The full article was not read because TG in the abstract means thapsigargin",""
+"Thyroid hormone synthesis","Toll-like receptor signaling pathway","TG Toll-like receptor Pathway","26045709","no","no","","","","","","","","","","","","","The full text was not read because TG in the abstract means Triglyceride",""
+"Toll-like receptor signaling pathway","Thyroid hormone synthesis","TG Toll-like receptor Pathway","26045709","no","no","","","","","","","","","","","","","The full text was not read because TG in the abstract means Triglyceride",""
+"Thyroid hormone synthesis","VEGF signaling pathway","TSH VEGF Cross-talk","12388152","no","no","","","","","","","","","","","","","The text indicates that TSH may have an effect on the secretion of VEGF, but no direct relationship is implied",""
+"VEGF signaling pathway","Thyroid hormone synthesis","TSH VEGF Cross-talk","12388152","no","no","","","","","","","","","","","","","The text indicates that TSH may have an effect on the secretion of VEGF, but no direct relationship is implied",""
+"Thyroid hormone synthesis","VEGF signaling pathway","TSH VEGF Pathway","25406019","no","no","","","","","","","","","","","","","The full article was not read because the abstract mainly discusses HIF-1 and VEGF and mentions the study being TSH-independent",""
+"VEGF signaling pathway","Thyroid hormone synthesis","TSH VEGF Pathway","25406019","no","no","","","","","","","","","","","","","The full article was not read because the abstract mainly discusses HIF-1 and VEGF and mentions the study being TSH-independent",""
+"Thyroid hormone synthesis","VEGF signaling pathway","TSH VEGF Pathway","9400995","yes","yes","activating","CGA","P01215","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","thyroid gland","BTO:0001379","goiters","In fact, TSH treatment of cultured PC Cl 3 thyroid cells induced a time- and dose-dependent up-regulation of both PlGF and VEGF mRNA expression","The text mentions many times that TSH stimulates the expression of VEGF, but no direct interactions are mentioned",""
+"VEGF signaling pathway","Thyroid hormone synthesis","TSH VEGF Pathway","9400995","no","no","","","","","","","","","","","","","There only seemed to be an effect on VEGF by TSH",""
+"Thyroid hormone synthesis","VEGF signaling pathway","TSH VEGF Pathway","15579770","yes","yes","activating","CGA","P01215","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","thyroid gland","BTO:0001379","cancer","In summary, we have shown that TSH induces VEGF gene expression and protein secretion in thyroid carcinoma cell lines in vitro","The only relationship described is transcriptional, although this article does provide mechanisms composed of components of the TSH pathway",""
+"VEGF signaling pathway","Thyroid hormone synthesis","TSH VEGF Pathway","15579770","no","no","","","","","","","","","","","","","There only seemed to be an effect on VEGF by TSH",""
+"Thyroid hormone synthesis","VEGF signaling pathway","TSH VEGF Pathway","19336661","no","no","","","","","","","","","","","","","The text mainly discusses VEGF and HIF-1 and hardly mentions TSH",""
+"VEGF signaling pathway","Thyroid hormone synthesis","TSH VEGF Pathway","19336661","no","no","","","","","","","","","","","","","The text mainly discusses VEGF and HIF-1 and hardly mentions TSH",""
+"Thyroid hormone synthesis","Wnt signaling pathway","TSH Wnt Pathway","24645679","yes","no","activating","PRKACA","P17612","UNIPROT","CTNNB1","P35222","UNIPROT","Homo sapiens","thyroid gland","BTO:0001379","proliferation/differentiation","Thus, TSH induced β-catenin phosphorylation at S552 and S675 through PKA, whereas IGF-1 induced S552 phosphorylation in an Akt-dependent manner","The text is very clear and provides lots of detail about how each crosstalk occurs and it is clear that it is all through direct interactions",""
+"Thyroid hormone synthesis","Wnt signaling pathway","TSH Wnt Pathway","24645679","yes","no","activating","PRKACA","P17612","UNIPROT","GSK3B","P49841","UNIPROT","Homo sapiens","thyroid gland","BTO:0001379","proliferation/differentiation","These data are also in agreement with studies showing that TSH and IGF-1, via PKA and PI3K/Akt, phosphorylate GSK3β at S9, inhibiting its activity and consequently increasing thyroid cell proliferation","The text is very clear and provides lots of detail about how each crosstalk occurs and it is clear that it is all through direct interactions",""
+"Wnt signaling pathway","Thyroid hormone synthesis","TSH Wnt Pathway","24645679","yes","no","activating","CTNNB1","P35222","UNIPROT","PAX8","Q06710","UNIPROT","Homo sapiens","thyroid gland","BTO:0001379","proliferation/differentiation","Finally, we observed that β-catenin physically interacts with the transcription factor Pax8, increasing its transcriptional activity on the sodium iodide symporter (NIS) gene, a critical gene required for thyroid cell physiology","The text is very clear and provides lots of detail about how each crosstalk occurs and it is clear that it is all through direct interactions",""
+"mTOR signaling pathway","Adipocytokine signaling pathway","mTOR Adipocytokine Crosstalk","23104651","yes","no","inhibiting","MTOR","P42345","UNIPROT","IRS1","P35568","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","IGF-I treatment converge downstream onto mTOR to induce IRS-1 Ser312 phosphorylation","The article states that mTOR and IRS1 interact and that mTOR down-regulates IRS1 activity, and it explains that this is done through phosphorylation of IRS1",""
+"Adipocytokine signaling pathway","mTOR signaling pathway","mTOR Adipocytokine Crosstalk","23104651","yes","yes","activating","LEP","P41159","UNIPROT","PRKCA","P17252","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Leptin also induces the PI3K/Akt/mTOR survival pathway by activating the phosphorylation of Akt Thr308 or Akt Ser473 and by stimulating the protein expression of protein kinase C-alpha (PKC-alpha), which is controlled by PI3K","There is a clear transcriptional relationship, but the sentence provided also seems to suggest another direct crosstalk, but since the sentence says that leptin activates the phosphorylation of Akt, the crosstalk is ambiguous",""
+"Adipocytokine signaling pathway","mTOR signaling pathway","mTOR Adipocytokine Crosstalk","23104651","yes","yes","inhibiting","ADIPOQ","Q15848","UNIPROT","STK11","Q15831","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Besides, adiponectin repressed proligeration in breast cancer cells is mediated through an inactivation of p44/42 MAPK (mitogen-activated-protein-kinase) protein 1 and 3 expression, a stimulation of adenosine monophosphate-activated protein kinase (AMPK) activity by phosphorylation at Thr172 and a decrease in Akt phosphorylation (Thr308) associated with an increased expression of liver kinase B1 (LKB1) leading to a reduction of mTOR activity as evidenced by reduced phosphorylation of S6K","The effect that adiponectin has on the mTOR pathway is very confusing, but it seems that adiponectin decreases Akt phosphorylation by increasing the expression of LKB1",""
+"Adipocytokine signaling pathway","mTOR signaling pathway","mTOR Adipocytokine Crosstalk","23104651","yes","no","inhibiting","ADIPOQ","Q15848","UNIPROT","PRKAA1","Q13131","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","Besides, adiponectin repressed proligeration in breast cancer cells is mediated through an inactivation of p44/42 MAPK (mitogen-activated-protein-kinase) protein 1 and 3 expression, a stimulation of adenosine monophosphate-activated protein kinase (AMPK) activity by phosphorylation at Thr172 and a decrease in Akt phosphorylation (Thr308) associated with an increased expression of liver kinase B1 (LKB1) leading to a reduction of mTOR activity as evidenced by reduced phosphorylation of S6K","The text seems to indicate that adiponectin directly phosphorylates AMPK. It is clear that the Adipocytokine and mTOR pathways have many of the same components, so it is not surprising that they have so many points of crosstalk",""
+"mTOR signaling pathway","ErbB signaling pathway","mTOR ErbB Crosstalk","22922893","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only discussed in having a potential role in cancer treatment resistance, but there was no mention of a potential interaction between them in the abstract",""
+"ErbB signaling pathway","mTOR signaling pathway","mTOR ErbB Crosstalk","22922893","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only discussed in having a potential role in cancer treatment resistance, but there was no mention of a potential interaction between them in the abstract",""
+"mTOR signaling pathway","ErbB signaling pathway","mTOR ErbB Crosstalk","24011769","no","no","","","","","","","","","","","","","The full article was not read because there was no mention of ErbB in the abstract",""
+"ErbB signaling pathway","mTOR signaling pathway","mTOR ErbB Crosstalk","24011769","no","no","","","","","","","","","","","","","The full article was not read because there was no mention of ErbB in the abstract",""
+"mTOR signaling pathway","ErbB signaling pathway","mTOR ErbB Crosstalk","24937674","no","no","","","","","","","","","","","","","The text does not mention any interactions with ErbB",""
+"ErbB signaling pathway","mTOR signaling pathway","mTOR ErbB Crosstalk","24937674","no","no","","","","","","","","","","","","","The text does not mention any interactions with ErbB",""
+"mTOR signaling pathway","ErbB signaling pathway","mTOR ErbB Crosstalk","23994522","no","no","","","","","","","","","","","","","The full article was not read because mTOR was not mentioned in the abstract",""
+"ErbB signaling pathway","mTOR signaling pathway","mTOR ErbB Crosstalk","23994522","no","no","","","","","","","","","","","","","The full article was not read because mTOR was not mentioned in the abstract",""
+"mTOR signaling pathway","ErbB signaling pathway","mTOR ErbB Crosstalk","23358316","no","no","","","","","","","","","","","","","The full paper was not read because neither pathway was mentioned in the abstract",""
+"ErbB signaling pathway","mTOR signaling pathway","mTOR ErbB Crosstalk","23358316","no","no","","","","","","","","","","","","","The full paper was not read because neither pathway was mentioned in the abstract",""
+"mTOR signaling pathway","Estrogen signaling pathway","mTOR Estrogen Crosstalk","25771071","no","no","","","","","","","","","","","","","The full text was not read because mTOR was not mentioned in the abstract",""
+"Estrogen signaling pathway","mTOR signaling pathway","mTOR Estrogen Crosstalk","25771071","no","no","","","","","","","","","","","","","The full text was not read because mTOR was not mentioned in the abstract",""
+"mTOR signaling pathway","Estrogen signaling pathway","mTOR Estrogen Crosstalk","24366110","no","no","","","","","","","","","","","","","There only seemed to be an effect on mTOR by ER",""
+"Estrogen signaling pathway","mTOR signaling pathway","mTOR Estrogen Crosstalk","24366110","yes","no","activating","ESR1","P03372","UNIPROT","PIK3CA","P42336","UNIPROT","Homo sapiens","uterine endometrium","BTO:0001422","cancer","Our data showed that ERα raised the phosphorylation levels of PI3K p85α and subsequently activated phosphorylation of AKT/mTOR in Ishikawa and KLE cells, but ERβ had no effect on PI3K p85α phosphorylation","The text isn't completely clear on the mechanism of how ERalpha activates the mTOR pathway, but it seems the effect is direct",""
+"mTOR signaling pathway","Estrogen signaling pathway","mTOR Estrogen Crosstalk","25961241","no","no","","","","","","","","","","","","","The full article was not read because there was no mention in the abstract of any potential interactions between mTOR and estrogen",""
+"Estrogen signaling pathway","mTOR signaling pathway","mTOR Estrogen Crosstalk","25961241","no","no","","","","","","","","","","","","","The full article was not read because there was no mention in the abstract of any potential interactions between mTOR and estrogen",""
+"mTOR signaling pathway","Estrogen signaling pathway","mTOR Estrogen Crosstalk","23994522","no","no","","","","","","","","","","","","","The full paper was not read because mTOR was not mentioned in the abstract",""
+"Estrogen signaling pathway","mTOR signaling pathway","mTOR Estrogen Crosstalk","23994522","no","no","","","","","","","","","","","","","The full paper was not read because mTOR was not mentioned in the abstract",""
+"mTOR signaling pathway","Estrogen signaling pathway","mTOR Estrogen Crosstalk","22252523","no","no","","","","","","","","","","","","","The full article was not read because both pathways were mentioned in a different context in the abstract",""
+"Estrogen signaling pathway","mTOR signaling pathway","mTOR Estrogen Crosstalk","22252523","no","no","","","","","","","","","","","","","The full article was not read because both pathways were mentioned in a different context in the abstract",""
+"mTOR signaling pathway","GnRH signaling pathway","mTOR GnRH Crosstalk","22922893","no","no","","","","","","","","","","","","","The full article was not read because mTOR was barely mentioned in the abstract and in a different context than GnRH",""
+"GnRH signaling pathway","mTOR signaling pathway","mTOR GnRH Crosstalk","22922893","no","no","","","","","","","","","","","","","The full article was not read because mTOR was barely mentioned in the abstract and in a different context than GnRH",""
+"mTOR signaling pathway","GnRH signaling pathway","mTOR GnRH Pathway","22695254","no","no","","","","","","","","","","","","","The full text was not read because GnRH was not mentioned in the abstract",""
+"GnRH signaling pathway","mTOR signaling pathway","mTOR GnRH Pathway","22695254","no","no","","","","","","","","","","","","","The full text was not read because GnRH was not mentioned in the abstract",""
+"mTOR signaling pathway","GnRH signaling pathway","mTOR GnRH Pathway","11075814","no","no","","","","","","","","","","","","","The full paper was not read because there was no mention of mTOR in the abstract",""
+"GnRH signaling pathway","mTOR signaling pathway","mTOR GnRH Pathway","11075814","no","no","","","","","","","","","","","","","The full paper was not read because there was no mention of mTOR in the abstract",""
+"mTOR signaling pathway","GnRH signaling pathway","mTOR GnRH Pathway","20362974","no","no","","","","","","","","","","","","","The text mentions a possible interaction between GnRH and mTOR, but provides no evidence or details and does not go into depth at all. The full article is not available through PubMed but is available through the library",""
+"GnRH signaling pathway","mTOR signaling pathway","mTOR GnRH Pathway","20362974","no","no","","","","","","","","","","","","","The text mentions a possible interaction between GnRH and mTOR, but provides no evidence or details and does not go into depth at all. The full article is not available through PubMed but is available through the library",""
+"mTOR signaling pathway","GnRH signaling pathway","mTOR MMP Cross-talk","24164895","no","no","","","","","","","","","","","","","The text mainly discussed mTOR and HIF-1",""
+"GnRH signaling pathway","mTOR signaling pathway","mTOR MMP Cross-talk","24164895","no","no","","","","","","","","","","","","","The text mainly discussed mTOR and HIF-2",""
+"mTOR signaling pathway","HIF-1 signaling pathway","mTOR HIF-1 Crosstalk","25756515","no","no","","","","","","","","","","","","","The text made suggestions of a relationship between mTOR and HIF-1, but there are no details and no mechanism explained, so it is too ambiguous",""
+"HIF-1 signaling pathway","mTOR signaling pathway","mTOR HIF-1 Crosstalk","25756515","no","no","","","","","","","","","","","","","The text made suggestions of a relationship between mTOR and HIF-1, but there are no details and no mechanism explained, so it is too ambiguous",""
+"mTOR signaling pathway","HIF-1 signaling pathway","mTOR HIF-1 Crosstalk","25180793","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of HIF-1 in the abstract",""
+"HIF-1 signaling pathway","mTOR signaling pathway","mTOR HIF-1 Crosstalk","25180793","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of HIF-1 in the abstract",""
+"mTOR signaling pathway","HIF-1 signaling pathway","mTOR HIF-1 Crosstalk","19177014","no","no","","","","","","","","","","","","","The text suggests that there is crosstalk between HIF-1 and mTOR, but provides no detail or any mechanism, and it is very ambiguous",""
+"HIF-1 signaling pathway","mTOR signaling pathway","mTOR HIF-1 Crosstalk","19177014","no","no","","","","","","","","","","","","","The text suggests that there is crosstalk between HIF-1 and mTOR, but provides no detail or any mechanism, and it is very ambiguous",""
+"mTOR signaling pathway","HIF-1 signaling pathway","mTOR HIF-1 Crosstalk","19595306","no","no","","","","","","","","","","","","","The text did not give any evidence of any interaction between HIF-1 and mTOR",""
+"HIF-1 signaling pathway","mTOR signaling pathway","mTOR HIF-1 Crosstalk","19595306","no","no","","","","","","","","","","","","","The text did not give any evidence of any interaction between HIF-1 and mTOR",""
+"mTOR signaling pathway","HIF-1 signaling pathway","mTOR HIF-1 Cross-talk","24164895","yes","yes","activating","RPS6KB1","P23443","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","many","","tumor malignancy","HIF-1α is a downstream target of these factors (mTOR transcription factors); therefore, mTOR increases the amount of HIF-1 protein","The text does not give a lot of detail, but it does say that HIF-1 is a direct target of mTOR transcription factors",""
+"HIF-1 signaling pathway","mTOR signaling pathway","mTOR HIF-1 Cross-talk","24164895","no","no","","","","","","","","","","","","","There only seemed to be an effect on HIF-1 by mTOR",""
+"mTOR signaling pathway","Hippo signaling pathway","mTOR Hippo Crosstalk","25998128","yes","no","activating","Mtor","Q9JLN9","UNIPROT","Amotl2","Q8K371","UNIPROT","Mus musculus","glial cell","BTO:0002606","glioblastoma","Our work supports the hypothesis that mTORC2 is able to phosphorylate Ser760 of AMOTL2 resulting in the blockade of its YAP binding properties leading to activation of YAP-target genes","The text states that mTOR specifically phosphorylates AMOTL so that it can no longer bind to YAP and YAP can activate transcription of target genes",""
+"Hippo signaling pathway","mTOR signaling pathway","mTOR Hippo Crosstalk","25998128","no","no","","","","","","","","","","","","","The text suggested an effect on mTOR by Hippo, but it seemed to be indirect",""
+"mTOR signaling pathway","Hippo signaling pathway","mTOR Hippo Crosstalk","23143395","no","no","","","","","","","","","","","","","There only seemed to be an effec on mTOR by Hippo",""
+"Hippo signaling pathway","mTOR signaling pathway","mTOR Hippo Crosstalk","23143395","yes","yes","activating","miR-29","miR","miR","PTEN","P60484","UNIPROT","Homo sapiens","many","","organ growth","YAP mediates the major effects of the Hippo pathway by regulating gene expression and among the YAP target genes is the miR-29 family, which inhibits PTEN by targeting its 3′UTR","The effect seems direct, but since miR-29 is a target gene of the Hippo pathway and not an active component, the crosstalk is transcriptional",""
+"mTOR signaling pathway","Hippo signaling pathway","mTOR Hippo Crosstalk","24556838","no","no","","","","","","","","","","","","","There only seemed to be an effec on mTOR by Hippo",""
+"Hippo signaling pathway","mTOR signaling pathway","mTOR Hippo Crosstalk","24556838","yes","yes","activating","miR-29","miR","miR","Pten","O08586","UNIPROT","Mus musculus","many","","growth","YAP stimulates transcription of the microRNA miR-29, which inhibits the translation of PTEN","The effect seems direct, but since miR-29 is a target gene of the Hippo pathway and not an active component, the crosstalk is transcriptional",""
+"mTOR signaling pathway","Hippo signaling pathway","mTOR Hippo Crosstalk","25288394","no","no","","","","","","","","","","","","","The abstract suggested crosstalk, but the article was much too ambiguous",""
+"Hippo signaling pathway","mTOR signaling pathway","mTOR Hippo Crosstalk","25288394","no","no","","","","","","","","","","","","","The abstract suggested crosstalk, but the article was much too ambiguous",""
+"mTOR signaling pathway","Hippo signaling pathway","mTOR Hippo Crosstalk","25843706","yes","no","inhibiting","Mtor","Q9JLN9","UNIPROT","Mst1","P26928","UNIPROT","Mus musculus","cardiac","","stress response","mTORC2 phosphorylates MST1 at serine 438 in the SARAH domain and reduces its ability to homodimerize and become activated","The text specifically states that mTORC directly phosphorylates MST1",""
+"Hippo signaling pathway","mTOR signaling pathway","mTOR Hippo Crosstalk","25843706","yes","yes","activating","miR-29","miR","miR","Pten","O08586","UNIPROT","Mus musculus","cardiac","","stress response","Of note, previous evidence from Guan’s laboratory indicated that YAP, a main target of inhibition by the Hippo pathway, can activate AKT through miR-29-mediated inhibition of PTEN","The effect seems direct, but since miR-29 is a target gene of the Hippo pathway and not an active component, the crosstalk is transcriptional",""
+"Hippo signaling pathway","mTOR signaling pathway","mTOR Hippo Crosstalk","25843706","yes","no","inhibiting","Mst1","P26928","UNIPROT","Akt1","P31750","UNIPROT","Mus musculus","cardiac","","stress response","In addition, AKT and MST1 were previously shown to mutually inhibit each other","The sentence provided is the only evidence given for this crosstalk, but the text gives no indication that it is not direct",""
+"mTOR signaling pathway","Insulin signaling pathway","mTOR Insulin Crosstalk","22846606","no","no","","","","","","","","","","","","","The text mainly discusses interactions with mTOR and AMPK, and while AMPK is part of both pathways, the text seems to suggest that the AMPK being discussed is part of the mTOR pathway, and this interaction only has an effect on insulin sensitivity, but it does not mention an interaction with the insulin pathway",""
+"Insulin signaling pathway","mTOR signaling pathway","mTOR Insulin Crosstalk","22846606","no","no","","","","","","","","","","","","","The text mainly discusses interactions with mTOR and AMPK, and while AMPK is part of both pathways, the text seems to suggest that the AMPK being discussed is part of the mTOR pathway, and this interaction only has an effect on insulin sensitivity, but it does not mention an interaction with the insulin pathway",""
+"mTOR signaling pathway","Insulin signaling pathway","mTOR Insulin Crosstalk","25295009","no","no","","","","","","","","","","","","","The text suggested a relationship between insulin and mTOR, but it mainly discusses crosstalk between insulin and different GPCR complexes, and didn't really give any evidence/detail for crosstalk with mTOR",""
+"Insulin signaling pathway","mTOR signaling pathway","mTOR Insulin Crosstalk","25295009","no","no","","","","","","","","","","","","","The text suggested a relationship between insulin and mTOR, but it mainly discusses crosstalk between insulin and different GPCR complexes, and didn't really give any evidence/detail for crosstalk with mTOR",""
+"mTOR signaling pathway","Insulin signaling pathway","mTOR Insulin Crosstalk","25961241","yes","yes","inhibiting","MTOR/RPS6KB1","P42345/P23443","UNIPROT","IRS1","P35568","UNIPROT","Homo sapiens","breast","BTO:0000149","cancer","However, mTOR/S6K is known to downregulate IGF1R signalling in breast cancer cells, at least in part, through loss of insulin receptor substract-1 expression and consequent inhibition of the PI3K pathway","There is not much detail given, but it does seem that mTOR has a transcriptional effect on IRS-1. The full text was not available through PubMed but was available through the library and has been saved",""
+"Insulin signaling pathway","mTOR signaling pathway","mTOR Insulin Crosstalk","25961241","no","no","","","","","","","","","","","","","There only seemed to be an effect on insulin by mTOR. The full text was not available through PubMed but was available through the library and has been saved",""
+"mTOR signaling pathway","Insulin signaling pathway","mTOR Insulin Crosstalk","25268093","no","no","","","","","","","","","","","","","The text only describes each pathway being involved with TSC, but not each other",""
+"Insulin signaling pathway","mTOR signaling pathway","mTOR Insulin Crosstalk","25268093","no","no","","","","","","","","","","","","","The text only describes each pathway being involved with TSC, but not each other",""
+"mTOR signaling pathway","Insulin signaling pathway","mTOR Insulin Crosstalk","23770045","no","no","","","","","","","","","","","","","The full text was not read because neither pathway was mentioned in the abstract",""
+"Insulin signaling pathway","mTOR signaling pathway","mTOR Insulin Crosstalk","23770045","no","no","","","","","","","","","","","","","The full text was not read because neither pathway was mentioned in the abstract",""
+"mTOR signaling pathway","Jak-STAT signaling pathway","mTOR Jak-STAT Crosstalk","23016985","no","no","","","","","","","","","","","","","The text only discusses how boht may be involved in HCC, but there is no mention of any interaction between them",""
+"Jak-STAT signaling pathway","mTOR signaling pathway","mTOR Jak-STAT Crosstalk","23016985","no","no","","","","","","","","","","","","","The text only discusses how boht may be involved in HCC, but there is no mention of any interaction between them",""
+"mTOR signaling pathway","Jak-STAT signaling pathway","mTOR Jak-STAT Crosstalk","10660304","yes","no","activating","MTOR","P42345","UNIPROT","STAT3","P40763","UNIPROT","Homo sapiens","neuroblastoma cell","BTO:0000931","neuroblastoma","Our data show that mTOR phosphorylates STAT3 at Ser727 in a CNTF-dependent manner in NBFL and HEK293T cells and that this serine phosphorylation is required for STAT3 to maximally activate transcription of a target gene","The text states that mTOR phosphorylates STAT3 to activate it",""
+"Jak-STAT signaling pathway","mTOR signaling pathway","mTOR Jak-STAT Crosstalk","10660304","no","no","","","","","","","","","","","","","There only seemed to be an effect on STAT by mTOR",""
+"mTOR signaling pathway","Jak-STAT signaling pathway","mTOR Jak-STAT Crosstalk","16391472","no","no","","","","","","","","","","","","","The text suggests a relationship between mTOR and Jak-STAT, but is much too ambiguous and gives no detail. The full text was not available through PubMed but was available through the library and has been saved",""
+"Jak-STAT signaling pathway","mTOR signaling pathway","mTOR Jak-STAT Crosstalk","16391472","no","no","","","","","","","","","","","","","The text suggests a relationship between mTOR and Jak-STAT, but is much too ambiguous and gives no detail. The full text was not available through PubMed but was available through the library and has been saved",""
+"mTOR signaling pathway","Jak-STAT signaling pathway","mTOR Jak-STAT Crosstalk","24619558","no","no","","","","","","","","","","","","","The abstract suggested crosstalk, but the text provides no evidence or detail for crosstalk between mTOR and Jak-STAT",""
+"Jak-STAT signaling pathway","mTOR signaling pathway","mTOR Jak-STAT Crosstalk","24619558","no","no","","","","","","","","","","","","","The abstract suggested crosstalk, but the text provides no evidence or detail for crosstalk between mTOR and Jak-STAT",""
+"mTOR signaling pathway","Jak-STAT signaling pathway","mTOR Jak-STAT Crosstalk","22102922","no","no","","","","","","","","","","","","","The text only mentioned each pathway has being expressed in mosquitos, but there was no suggestion of crosstalk between them",""
+"Jak-STAT signaling pathway","mTOR signaling pathway","mTOR Jak-STAT Crosstalk","22102922","no","no","","","","","","","","","","","","","The text only mentioned each pathway has being expressed in mosquitos, but there was no suggestion of crosstalk between them",""
+"mTOR signaling pathway","MAPK signaling pathway","mTOR MAPK Crosstalk","24509877","yes","no","inhibiting","AKT1","P31749","UNIPROT","RAF1","P04049","UNIPROT","Homo sapiens","many","","mutant NF1/cancer","MEK inhibitors induce epidermal growth factor-induced AKT activation, ERK phosphorylates TSC2 and RAPTOR to promote TORC1 activity, and AKT can phosphorylate Raf at inhibitory sites that negatively regulate MEK activity","Most of the text discusses a crosstalk between MAPK and mTOR that is mediated by a third component, but it also clearly (and briefly) states that components of both pathways phosphorylate components of the other pathway. So there is also a direct crosstalk described",""
+"MAPK signaling pathway","mTOR signaling pathway","mTOR MAPK Crosstalk","24509877","yes","no","activating","MAPK3/MAPK1","P27361/P28482","UNIPROT","TSC2,RPTOR","P49815,Q8N122","UNIPROT","Homo sapiens","many","","mutant NF1/cancer","MEK inhibitors induce epidermal growth factor-induced AKT activation, ERK phosphorylates TSC2 and RAPTOR to promote TORC1 activity, and AKT can phosphorylate Raf at inhibitory sites that negatively regulate MEK activity","Most of the text discusses a crosstalk between MAPK and mTOR that is mediated by a third component, but it also clearly (and briefly) states that components of both pathways phosphorylate components of the other pathway. So there is also a direct crosstalk described",""
+"mTOR signaling pathway","Neurotrophin signaling pathway","mTOR Neurotrophin Pathway","24118019","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned mTOR once and in a different context than Neurotrophin",""
+"Neurotrophin signaling pathway","mTOR signaling pathway","mTOR Neurotrophin Pathway","24118019","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned mTOR once and in a different context than Neurotrophin",""
+"mTOR signaling pathway","Neurotrophin signaling pathway","mTOR Neurotrophin Pathway","25241901","no","no","","","","","","","","","","","","","The full article was not read because in the abstract there was no potential interaction mentioned",""
+"Neurotrophin signaling pathway","mTOR signaling pathway","mTOR Neurotrophin Pathway","25241901","no","no","","","","","","","","","","","","","The full article was not read because in the abstract there was no potential interaction mentioned",""
+"mTOR signaling pathway","Neurotrophin signaling pathway","mTOR Neurotrophin Pathway","23285024","no","no","","","","","","","","","","","","","The text suggests a crosstalk, but it is too ambiguous",""
+"Neurotrophin signaling pathway","mTOR signaling pathway","mTOR Neurotrophin Pathway","23285024","no","no","","","","","","","","","","","","","The text suggests a crosstalk, but it is too ambiguous",""
+"mTOR signaling pathway","Neurotrophin signaling pathway","mTOR Neurotrophin Pathway","26066070","no","no","","","","","","","","","","","","","Again, the text suggests crosstalk but is too ambiguous",""
+"Neurotrophin signaling pathway","mTOR signaling pathway","mTOR Neurotrophin Pathway","26066070","no","no","","","","","","","","","","","","","Again, the text suggests crosstalk but is too ambiguous",""
+"mTOR signaling pathway","Neurotrophin signaling pathway","mTOR Neurotrophin Pathway","23075086","no","no","","","","","","","","","","","","","The full paper was not read because mTOR was not mentioned in the abstract",""
+"Neurotrophin signaling pathway","mTOR signaling pathway","mTOR Neurotrophin Pathway","23075086","no","no","","","","","","","","","","","","","The full paper was not read because mTOR was not mentioned in the abstract",""
+"mTOR signaling pathway","NF-kappa B signaling pathway","mTOR NF-kappa B Crosstalk","24670043","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentioned each pathway interacting with TGF-beta",""
+"NF-kappa B signaling pathway","mTOR signaling pathway","mTOR NF-kappa B Crosstalk","24670043","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentioned each pathway interacting with TGF-beta",""
+"mTOR signaling pathway","NF-kappa B signaling pathway","mTOR NF-kappa B Crosstalk","22186785","no","no","","","","","","","","","","","","","The paper was not read because mTOR was only mentioned once to say that it is a trigger for autophagy",""
+"NF-kappa B signaling pathway","mTOR signaling pathway","mTOR NF-kappa B Crosstalk","22186785","no","no","","","","","","","","","","","","","The paper was not read because mTOR was only mentioned once to say that it is a trigger for autophagy",""
+"mTOR signaling pathway","NF-kappa B signaling pathway","mTOR NF-kappa B Crosstalk","16959613","no","no","","","","","","","","","","","","","The text suggests that there is a crosstalk between mTOR and NF-kappa B, but it does not give any details or explanations",""
+"NF-kappa B signaling pathway","mTOR signaling pathway","mTOR NF-kappa B Crosstalk","16959613","no","no","","","","","","","","","","","","","The text suggests that there is a crosstalk between mTOR and NF-kappa B, but it does not give any details or explanations",""
+"mTOR signaling pathway","NF-kappa B signaling pathway","mTOR NF-kappa B Cross-talk","25027053","no","no","","","","","","","","","","","","","Again, the text suggests crosstalk but there is no evidence or details as to how the crosstalk occurs. Only a correlation is described",""
+"NF-kappa B signaling pathway","mTOR signaling pathway","mTOR NF-kappa B Cross-talk","25027053","no","no","","","","","","","","","","","","","Again, the text suggests crosstalk but there is no evidence or details as to how the crosstalk occurs. Only a correlation is described",""
+"mTOR signaling pathway","NF-kappa B signaling pathway","mTOR NF-kappa B Cross-talk","22992618","no","no","","","","","","","","","","","","","The full text was not read because there was no indication of any potential interactions in the abstract",""
+"NF-kappa B signaling pathway","mTOR signaling pathway","mTOR NF-kappa B Cross-talk","22992618","no","no","","","","","","","","","","","","","The full text was not read because there was no indication of any potential interactions in the abstract",""
+"mTOR signaling pathway","Prolactin signaling pathway","mTOR Prolactin Crosstalk","16899564","no","no","","","","","","","","","","","","","The text claims there is crosstalk, but then only describes indirect and ambiguous relationships, and does not give any concrete evidence for real crosstalk",""
+"Prolactin signaling pathway","mTOR signaling pathway","mTOR Prolactin Crosstalk","16899564","no","no","","","","","","","","","","","","","The text claims there is crosstalk, but then only describes indirect and ambiguous relationships, and does not give any concrete evidence for real crosstalk",""
+"mTOR signaling pathway","Prolactin signaling pathway","mTOR Prolactin Cross-talk","23581407","","","","","","","","","","","","","","","The full text was not available but has been requested",""
+"Prolactin signaling pathway","mTOR signaling pathway","mTOR Prolactin Cross-talk","23581407","","","","","","","","","","","","","","","The full text was not available but has been requested",""
+"mTOR signaling pathway","Prolactin signaling pathway","mTOR Prolactin Cross-talk","12065239","no","no","","","","","","","","","","","","","There only seemed to be an effect on mTOR by Prolactin",""
+"Prolactin signaling pathway","mTOR signaling pathway","mTOR Prolactin Cross-talk","12065239","yes","yes","inhibiting","Prl","P01237","UNIPROT","Igbp1","O08836","UNIPROT","Rattus norvegicus","thymus","BTO:0001374","normal","The present study showed that PRL downregulated Nb2 alpha4 mRNA expression which was accompanied by a modest decrease in alpha4 protein levels","The text describes other relationships between mTOR and Prolactin, but they are too ambiguous and not concrete enough. The text explains that alpha4 is a mTOR phosphoprotein, and Prolactin inhibits the expression of alpha4",""
+"Prolactin signaling pathway","mTOR signaling pathway","mTOR Prolactin Cross-talk","12065239","yes","yes","inhibiting","Prl","P01237","UNIPROT","Igbp1","O08836","UNIPROT","Rattus norvegicus","lymph","BTO:0000855","normal","The present study showed that PRL downregulated Nb2 alpha4 mRNA expression which was accompanied by a modest decrease in alpha4 protein levels","The text describes other relationships between mTOR and Prolactin, but they are too ambiguous and not concrete enough. The text explains that alpha4 is a mTOR phosphoprotein, and Prolactin inhibits the expression of alpha4",""
+"mTOR signaling pathway","Prolactin signaling pathway","mTOR Prolactin Pathway","22426621","no","no","","","","","","","","","","","","","The text claims there is crosstalk, but then only describes indirect and ambiguous relationships, and does not give any concrete evidence for real crosstalk",""
+"Prolactin signaling pathway","mTOR signaling pathway","mTOR Prolactin Pathway","22426621","no","no","","","","","","","","","","","","","The text claims there is crosstalk, but then only describes indirect and ambiguous relationships, and does not give any concrete evidence for real crosstalk",""
+"mTOR signaling pathway","Prolactin signaling pathway","mTOR Prolactin Pathway","23384836","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Prolactin signaling pathway","mTOR signaling pathway","mTOR Prolactin Pathway","23384836","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"mTOR signaling pathway","Prolactin signaling pathway","mTOR Prolactin Pathway","26183263","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Prolactin signaling pathway","mTOR signaling pathway","mTOR Prolactin Pathway","26183263","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"mTOR signaling pathway","TGF-beta signaling pathway","mTOR TGF-beta Crosstalk","24441193","no","no","","","","","","","","","","","","","The abstract suggested crosstalk, but there was no evidence of an interaction between mTOR and TGF-beta in the text",""
+"TGF-beta signaling pathway","mTOR signaling pathway","mTOR TGF-beta Crosstalk","24441193","no","no","","","","","","","","","","","","","The abstract suggested crosstalk, but there was no evidence of an interaction between mTOR and TGF-beta in the text",""
+"mTOR signaling pathway","TGF-beta signaling pathway","mTOR TGF-beta Crosstalk","24670043","no","no","","","","","","","","","","","","","The text did not mention any interaction between mTOR and TGF-beta",""
+"TGF-beta signaling pathway","mTOR signaling pathway","mTOR TGF-beta Crosstalk","24670043","no","no","","","","","","","","","","","","","The text did not mention any interaction between mTOR and TGF-beta",""
+"mTOR signaling pathway","TGF-beta signaling pathway","mTOR TGF-beta Crosstalk","17283241","no","no","","","","","","","","","","","","","The text states that TGF-beta acts independent of mTOR",""
+"TGF-beta signaling pathway","mTOR signaling pathway","mTOR TGF-beta Crosstalk","17283241","no","no","","","","","","","","","","","","","The text states that TGF-beta acts independent of mTOR",""
+"mTOR signaling pathway","TGF-beta signaling pathway","mTOR TGF-beta Cross-talk","18757300","no","no","","","","","","","","","","","","","The full text was not read because mTOR and TGF-beta were both mentioned in a different context in the abstract",""
+"TGF-beta signaling pathway","mTOR signaling pathway","mTOR TGF-beta Cross-talk","18757300","no","no","","","","","","","","","","","","","The full text was not read because mTOR and TGF-beta were both mentioned in a different context in the abstract",""
+"mTOR signaling pathway","TGF-beta signaling pathway","mTOR TGF-beta Cross-talk","15808954","no","no","","","","","","","","","","","","","The text did not describe any interaction between mTOR and TGF-beta",""
+"TGF-beta signaling pathway","mTOR signaling pathway","mTOR TGF-beta Cross-talk","15808954","no","no","","","","","","","","","","","","","The text did not describe any interaction between mTOR and TGF-beta",""
+"mTOR signaling pathway","TNF signaling pathway","mTOR TNF Crosstalk","22439934","no","no","","","","","","","","","","","","","The text mainly described crosstalk with Hedgehog, but since TNF is an activator of mTOR, TNF is discussed as part of the mTOR pathway, not part of the TNF pathway",""
+"TNF signaling pathway","mTOR signaling pathway","mTOR TNF Crosstalk","22439934","no","no","","","","","","","","","","","","","The text mainly described crosstalk with Hedgehog, but since TNF is an activator of mTOR, TNF is discussed as part of the mTOR pathway, not part of the TNF pathway",""
+"mTOR signaling pathway","TNF signaling pathway","mTOR TNF Crosstalk","23770045","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention either pathway",""
+"TNF signaling pathway","mTOR signaling pathway","mTOR TNF Crosstalk","23770045","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention either pathway",""
+"mTOR signaling pathway","TNF signaling pathway","mTOR TNF Cross-talk","24385238","no","no","","","","","","","","","","","","","The only relationship described in the text is indirect",""
+"TNF signaling pathway","mTOR signaling pathway","mTOR TNF Cross-talk","24385238","no","no","","","","","","","","","","","","","The only relationship described in the text is indirect",""
+"mTOR signaling pathway","TNF signaling pathway","mTOR TNF Cross-talk","23524951","no","no","","","","","","","","","","","","","The full article was not read because TNF was not mentioned in the abstract",""
+"TNF signaling pathway","mTOR signaling pathway","mTOR TNF Cross-talk","23524951","no","no","","","","","","","","","","","","","The full article was not read because TNF was not mentioned in the abstract",""
+"mTOR signaling pathway","TNF signaling pathway","mTOR TNF Cross-talk","20594757","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were mentioned in a different context",""
+"TNF signaling pathway","mTOR signaling pathway","mTOR TNF Cross-talk","20594757","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were mentioned in a different context",""
+"mTOR signaling pathway","Toll-like receptor signaling pathway","mTOR Toll-like receptor Cross-talk","20940366","no","no","","","","","","","","","","","","","The full text was not read because mTOR was not mentioned in the abstract",""
+"Toll-like receptor signaling pathway","mTOR signaling pathway","mTOR Toll-like receptor Cross-talk","20940366","no","no","","","","","","","","","","","","","The full text was not read because mTOR was not mentioned in the abstract",""
+"mTOR signaling pathway","Toll-like receptor signaling pathway","mTOR Toll-like receptor Pathway","25971793","no","no","","","","","","","","","","","","","The text did not mention any interaction between TLR and mTOR",""
+"Toll-like receptor signaling pathway","mTOR signaling pathway","mTOR Toll-like receptor Pathway","25971793","no","no","","","","","","","","","","","","","The text did not mention any interaction between TLR and mTOR",""
+"mTOR signaling pathway","Toll-like receptor signaling pathway","mTOR Toll-like receptor Pathway","25714412","no","no","","","","","","","","","","","","","The full article was not read because TLR was not mentioned in the abstract",""
+"Toll-like receptor signaling pathway","mTOR signaling pathway","mTOR Toll-like receptor Pathway","25714412","no","no","","","","","","","","","","","","","The full article was not read because TLR was not mentioned in the abstract",""
+"mTOR signaling pathway","Toll-like receptor signaling pathway","mTOR Toll-like receptor Pathway","20696947","no","no","","","","","","","","","","","","","The article suggests a relationship between TLR and mTOR, but it is too ambiguous to determine crosstalk",""
+"Toll-like receptor signaling pathway","mTOR signaling pathway","mTOR Toll-like receptor Pathway","20696947","no","no","","","","","","","","","","","","","The article suggests a relationship between TLR and mTOR, but it is too ambiguous to determine crosstalk",""
+"mTOR signaling pathway","Toll-like receptor signaling pathway","mTOR Toll-like receptor Pathway","22015781","no","no","","","","","","","","","","","","","The article suggests a relationship between TLR and mTOR, but it is too ambiguous to determine crosstalk",""
+"Toll-like receptor signaling pathway","mTOR signaling pathway","mTOR Toll-like receptor Pathway","22015781","no","no","","","","","","","","","","","","","The article suggests a relationship between TLR and mTOR, but it is too ambiguous to determine crosstalk",""
+"mTOR signaling pathway","VEGF signaling pathway","mTOR VEGF Crosstalk","25179535","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed mTOR and Notch",""
+"VEGF signaling pathway","mTOR signaling pathway","mTOR VEGF Crosstalk","25179535","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discussed mTOR and Notch",""
+"mTOR signaling pathway","VEGF signaling pathway","mTOR VEGF Crosstalk","21731759","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses how each pathway interacts with leptin",""
+"VEGF signaling pathway","mTOR signaling pathway","mTOR VEGF Crosstalk","21731759","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses how each pathway interacts with leptin",""
+"mTOR signaling pathway","VEGF signaling pathway","mTOR VEGF Crosstalk","20851763","no","no","","","","","","","","","","","","","There only seemed to be an effect on mTOR by VEGF",""
+"VEGF signaling pathway","mTOR signaling pathway","mTOR VEGF Crosstalk","20851763","yes","no","activating","KDR","P35968","UNIPROT","RPS6KB1","P23443","UNIPROT","Homo sapiens","neuroblastoma cell","BTO:0000931","serum starved","Our studies also revealed that the extent of S6K, S6 and Akt phosphorylation by VEGF and carbachol was enhanced by blocking tyrosine and to a greater extent serine/threonine dephosphorylation","The text states that VEGF phosphorylates S6K and other mTOR pathway components",""
+"mTOR signaling pathway","VEGF signaling pathway","mTOR VEGF Crosstalk","24180397","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were mentioned in a different context in the abstract",""
+"VEGF signaling pathway","mTOR signaling pathway","mTOR VEGF Crosstalk","24180397","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were mentioned in a different context in the abstract",""
+"mTOR signaling pathway","VEGF signaling pathway","mTOR VEGF Crosstalk","23358316","no","no","","","","","","","","","","","","","The full article was not read because neither pathway was mentioned in the abstract",""
+"VEGF signaling pathway","mTOR signaling pathway","mTOR VEGF Crosstalk","23358316","no","no","","","","","","","","","","","","","The full article was not read because neither pathway was mentioned in the abstract",""
+"mTOR signaling pathway","Wnt signaling pathway","mTOR Wnt Crosstalk","24556838","no","no","","","","","","","","","","","","","There only seemed to be an effect on mTOR by Wnt",""
+"Wnt signaling pathway","mTOR signaling pathway","mTOR Wnt Crosstalk","24556838","yes","no","inhibiting","Gsk3b","Q9WV60","UNIPROT","Tsc2","Q61037","UNIPROT","Mus musculus","many","","proliferation/differentiation","In the absence of WNT signalling, GSK3β phosphorylates TSC2 at Ser1379 and Ser1383 in a manner dependent on the AMPK-mediated phosphorylation of TSC2 at Ser1387","The text states that GSK3beta phosphorylates TSC2",""
+"mTOR signaling pathway","Wnt signaling pathway","mTOR Wnt Crosstalk","25857298","no","no","","","","","","","","","","","","","The text suggested crosstalk but did not provide any details or mechanisms",""
+"Wnt signaling pathway","mTOR signaling pathway","mTOR Wnt Crosstalk","25857298","no","no","","","","","","","","","","","","","The text suggested crosstalk but did not provide any details or mechanisms",""
+"mTOR signaling pathway","Wnt signaling pathway","mTOR Wnt Crosstalk","23911398","no","no","","","","","","","","","","","","","There only seemed to be an effect on mTOR by Wnt",""
+"Wnt signaling pathway","mTOR signaling pathway","mTOR Wnt Crosstalk","23911398","yes","no","inhibiting","","","","EIF4EBP1/RPS6KB1/RPS6","Q13541/P23443/P62753","UNIPROT","Homo sapiens","cytotoxic T-lymphocyte","BTO:0000289","cancer","Although wnt signaling inhibited mTOR and down-regulated 4EBP1 and p70S6K and S6 the addition of rapamycin enhanced the activation of 4EBP1 and p70S6k","There is not much detail provided, but the text does seem to suggest that something from the Wnt pathway directly inhibits the actions of 4EBP1/S6K/S6",""
+"mTOR signaling pathway","Wnt signaling pathway","mTOR Wnt Crosstalk","26156959","no","no","","","","","","","","","","","","","The full text was not read because there was only brief mention of mTOR in the abstract and in a different context than Wnt",""
+"Wnt signaling pathway","mTOR signaling pathway","mTOR Wnt Crosstalk","26156959","no","no","","","","","","","","","","","","","The full text was not read because there was only brief mention of mTOR in the abstract and in a different context than Wnt",""
+"mTOR signaling pathway","Wnt signaling pathway","mTOR Wnt Crosstalk","25388238","no","no","","","","","","","","","","","","","The text claims that there is crosstalk, but provides no evidence or mechanisms",""
+"Wnt signaling pathway","mTOR signaling pathway","mTOR Wnt Crosstalk","25388238","no","no","","","","","","","","","","","","","The text claims that there is crosstalk, but provides no evidence or mechanisms",""
+"Insulin signaling pathway","Hedgehog signaling pathway","GCG Hedgehog Pathway","17634527","no","no","","","","","","","","","","","","","The full text was not read because Hedgehog and GCG were both only mentioned once and in a different context",""
+"Hedgehog signaling pathway","Insulin signaling pathway","GCG Hedgehog Pathway","17634527","no","no","","","","","","","","","","","","","The full text was not read because Hedgehog and GCG were both only mentioned once and in a different context",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Glucagon Hedgehog Pathway","25354792","no","no","","","","","","","","","","","","","The full article was not read because both pathways were mentioned in a different context",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Glucagon Hedgehog Pathway","25354792","no","no","","","","","","","","","","","","","The full article was not read because both pathways were mentioned in a different context",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Glucagon Hedgehog Pathway","19924023","no","no","","","","","","","","","","","","","The abstract suggests crosstalk, but the text does not describe any interactions between GLP-1 and Hedgehog",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Glucagon Hedgehog Pathway","19924023","no","no","","","","","","","","","","","","","The abstract suggests crosstalk, but the text does not describe any interactions between GLP-1 and Hedgehog",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Glucagon Hedgehog Pathway","22069255","no","no","","","","","","","","","","","","","The full article was not read because both pathways were mentioned in a different context",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Glucagon Hedgehog Pathway","22069255","no","no","","","","","","","","","","","","","The full article was not read because both pathways were mentioned in a different context",""
+"Insulin signaling pathway","Hedgehog signaling pathway","Glucagon Hedgehog Pathway","18673242","no","no","","","","","","","","","","","","","The full paper was not read because the abstract on discusses how each pathway interacts with Wnt",""
+"Hedgehog signaling pathway","Insulin signaling pathway","Glucagon Hedgehog Pathway","18673242","no","no","","","","","","","","","","","","","The full paper was not read because the abstract on discusses how each pathway interacts with Wnt",""
+"Insulin signaling pathway","Notch signaling pathway","GCG Notch Pathway","17634527","no","no","","","","","","","","","","","","","The full paper was not read because the abstract mainly discussed Wnt and only mentioned Notch and GCG in a different context",""
+"Notch signaling pathway","Insulin signaling pathway","GCG Notch Pathway","17634527","no","no","","","","","","","","","","","","","The full paper was not read because the abstract mainly discussed Wnt and only mentioned Notch and GCG in a different context",""
+"Insulin signaling pathway","Notch signaling pathway","GLP-1 Notch Cross-talk","24586407","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentioned each one to say it is involved in tumors, but not with each other",""
+"Notch signaling pathway","Insulin signaling pathway","GLP-1 Notch Cross-talk","24586407","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentioned each one to say it is involved in tumors, but not with each other",""
+"Insulin signaling pathway","Notch signaling pathway","GLP-1 Notch Pathway","25500886","no","no","","","","","","","","","","","","","The full text was not read because in the abstract both were mentioned in a different context",""
+"Notch signaling pathway","Insulin signaling pathway","GLP-1 Notch Pathway","25500886","no","no","","","","","","","","","","","","","The full text was not read because in the abstract both were mentioned in a different context",""
+"Insulin signaling pathway","Notch signaling pathway","GLP-1 Notch Pathway","25552605","no","no","","","","","","","","","","","","","The abstract suggested potential crosstalk, but there is none discussed in the text",""
+"Notch signaling pathway","Insulin signaling pathway","GLP-1 Notch Pathway","25552605","no","no","","","","","","","","","","","","","The abstract suggested potential crosstalk, but there is none discussed in the text",""
+"Insulin signaling pathway","Notch signaling pathway","GLP-1 Notch Pathway","22209900","no","no","","","","","","","","","","","","","The abstract suggested potential crosstalk, but there is none discussed in the text",""
+"Notch signaling pathway","Insulin signaling pathway","GLP-1 Notch Pathway","22209900","no","no","","","","","","","","","","","","","The abstract suggested potential crosstalk, but there is none discussed in the text",""
+"Insulin signaling pathway","Melanogenesis","Glucagon MSH Pathway","11331393","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Melanogenesis","Insulin signaling pathway","Glucagon MSH Pathway","11331393","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Insulin signaling pathway","Melanogenesis","Glucagon MSH Pathway","6263051","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Melanogenesis","Insulin signaling pathway","Glucagon MSH Pathway","6263051","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Insulin signaling pathway","Melanogenesis","Glucagon MSH Pathway","12419401","no","no","","","","","","","","","","","","","The text discusses a relationship between MSH and GLP-1, but provides no evidence of an interaction",""
+"Melanogenesis","Insulin signaling pathway","Glucagon MSH Pathway","12419401","no","no","","","","","","","","","","","","","The text discusses a relationship between MSH and GLP-1, but provides no evidence of an interaction",""
+"Insulin signaling pathway","Melanogenesis","GLP-1 POMC Pathway","24719110","no","no","","","","","","","","","","","","","The full article was not read because POMC was not mentioned in the abstract",""
+"Melanogenesis","Insulin signaling pathway","GLP-1 POMC Pathway","24719110","no","no","","","","","","","","","","","","","The full article was not read because POMC was not mentioned in the abstract",""
+"Insulin signaling pathway","Melanogenesis","GLP-1 POMC Pathway","24222040","no","no","","","","","","","","","","","","","The full article was not read because POMC was not mentioned in the abstract",""
+"Melanogenesis","Insulin signaling pathway","GLP-1 POMC Pathway","24222040","no","no","","","","","","","","","","","","","The full article was not read because POMC was not mentioned in the abstract",""
+"Insulin signaling pathway","Progesterone-mediated oocyte maturation","GLP-1 Progesterone Pathway","25044020","no","no","","","","","","","","","","","","","There only seemed to be an effect on insulin secretion by progesterone",""
+"Progesterone-mediated oocyte maturation","Insulin signaling pathway","GLP-1 Progesterone Pathway","25044020","yes","no","activating","PGRMC1","Other","Other","I79_011522","G3HLD4","UNIPROT","Mesocricetus auratus","pancreatic beta cell","BTO:0000783","normal","These results collectively indicate that endogenous PGRMC1 is a component of the liganded GLP-1R complex and potentiates cAMP signaling to increase GIIS in β cells.","The text states that a component of the progesterone receptor forms a complex with GLP-1 receptor",""
+"Insulin signaling pathway","Progesterone-mediated oocyte maturation","Epac Progesterone Pathway","20663796","no","no","","","","","","","","","","","","","The full text was not read because in the abstract both pathways were mentioned in a different context",""
+"Progesterone-mediated oocyte maturation","Insulin signaling pathway","Epac Progesterone Pathway","20663796","no","no","","","","","","","","","","","","","The full text was not read because in the abstract both pathways were mentioned in a different context",""
+"Insulin signaling pathway","Progesterone-mediated oocyte maturation","CCK Progesterone Pathway","25608836","no","no","","","","","","","","","","","","","The full article was not read because CCK in the abstract means cell counting kit",""
+"Progesterone-mediated oocyte maturation","Insulin signaling pathway","CCK Progesterone Pathway","25608836","no","no","","","","","","","","","","","","","The full article was not read because CCK in the abstract means cell counting kit",""
+"Insulin signaling pathway","Progesterone-mediated oocyte maturation","Glucagon Progesterone Cross-talk","19627176","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were only briefly mentioned and not in a context where they would interact with each other",""
+"Progesterone-mediated oocyte maturation","Insulin signaling pathway","Glucagon Progesterone Cross-talk","19627176","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were only briefly mentioned and not in a context where they would interact with each other",""
+"Insulin signaling pathway","Progesterone-mediated oocyte maturation","Glucagon Progesterone Pathway","1327133","no","no","","","","","","","","","","","","","The full text was not read because in the abstract both pathways were only mentioned to state their potential effects on LPL",""
+"Progesterone-mediated oocyte maturation","Insulin signaling pathway","Glucagon Progesterone Pathway","1327133","no","no","","","","","","","","","","","","","The full text was not read because in the abstract both pathways were only mentioned to state their potential effects on LPL",""
+"Insulin signaling pathway","Thyroid hormone synthesis","Glucagon TSH Pathway","6088380","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Thyroid hormone synthesis","Insulin signaling pathway","Glucagon TSH Pathway","6088380","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Insulin signaling pathway","Thyroid hormone synthesis","GIP TSH Pathway","9024242","no","no","","","","","","","","","","","","","The full article was not read because the GIP in the abstract is not the same as the one from insulin secretion",""
+"Thyroid hormone synthesis","Insulin signaling pathway","GIP TSH Pathway","9024242","no","no","","","","","","","","","","","","","The full article was not read because the GIP in the abstract is not the same as the one from insulin secretion",""
+"Insulin signaling pathway","Thyroid hormone synthesis","Epac TSH Pathway","25372777","no","no","","","","","","","","","","","","","The text suggested a relationship between Epac and TSH, but did not provide enough details and was too ambiguous. The full text was unavailable through PubMed, but was available through the library and has been saved",""
+"Thyroid hormone synthesis","Insulin signaling pathway","Epac TSH Pathway","25372777","no","no","","","","","","","","","","","","","The text suggested a relationship between Epac and TSH, but did not provide enough details and was too ambiguous. The full text was unavailable through PubMed, but was available through the library and has been saved",""
+"Insulin signaling pathway","Thyroid hormone synthesis","Epac TSH Pathway","22240166","no","no","","","","","","","","","","","","","The full paper was not read because the abstract states that TSH and Epac are independent",""
+"Thyroid hormone synthesis","Insulin signaling pathway","Epac TSH Pathway","22240166","no","no","","","","","","","","","","","","","The full paper was not read because the abstract states that TSH and Epac are independent",""
+"Insulin signaling pathway","Thyroid hormone synthesis","Epac TSH Pathway","11375794","no","no","","","","","","","","","","","","","The full text was not read because in the abstract TSH is hardly mentioned and the abstract states that Epac doesn't have an effect on the study being discussed",""
+"Thyroid hormone synthesis","Insulin signaling pathway","Epac TSH Pathway","11375794","no","no","","","","","","","","","","","","","The full text was not read because in the abstract TSH is hardly mentioned and the abstract states that Epac doesn't have an effect on the study being discussed",""
+"Insulin signaling pathway","mTOR signaling pathway","GLP-1 mTOR Pathway","23116613","no","no","","","","","","","","","","","","","The text keeps suggesting crosstalk but only provides real evidence of the relationship by saying that a GLP-1 analogue changes the levels of ATP, which skews the ATP/AMP ratio, which inhibits AMPK and activates mTOR, so the relationship is indirect",""
+"mTOR signaling pathway","Insulin signaling pathway","GLP-1 mTOR Pathway","23116613","no","no","","","","","","","","","","","","","The text keeps suggesting crosstalk but only provides real evidence of the relationship by saying that a GLP-1 analogue changes the levels of ATP, which skews the ATP/AMP ratio, which inhibits AMPK and activates mTOR, so the relationship is indirect",""
+"Insulin signaling pathway","mTOR signaling pathway","GLP-1 mTOR Pathway","22311299","no","no","","","","","","","","","","","","","The text suggests crosstalk, but is much too ambiguous and does not provide enough evidence or details to determine crosstalk",""
+"mTOR signaling pathway","Insulin signaling pathway","GLP-1 mTOR Pathway","22311299","no","no","","","","","","","","","","","","","The text suggests crosstalk, but is much too ambiguous and does not provide enough evidence or details to determine crosstalk",""
+"Insulin signaling pathway","mTOR signaling pathway","GLP-1 mTOR Pathway","24909811","no","no","","","","","","","","","","","","","The only relationship between mTOR and GLP-1 described in the text is indirect. The full text was not available through PubMed but was available through the library and has been saved",""
+"mTOR signaling pathway","Insulin signaling pathway","GLP-1 mTOR Pathway","24909811","no","no","","","","","","","","","","","","","The only relationship between mTOR and GLP-1 described in the text is indirect. The full text was not available through PubMed but was available through the library and has been saved",""
+"Insulin signaling pathway","mTOR signaling pathway","GLP-1 mTOR Pathway","23147408","no","no","","","","","","","","","","","","","The text states that GLP-1 acts through EGFR and does not interact with mTOR directly. The text was only available through the library and is saved",""
+"mTOR signaling pathway","Insulin signaling pathway","GLP-1 mTOR Pathway","23147408","no","no","","","","","","","","","","","","","The text states that GLP-1 acts through EGFR and does not interact with mTOR directly. The text was only available through the library and is saved",""
+"Insulin signaling pathway","mTOR signaling pathway","GLP-1 mTOR Pathway","19463904","yes","no","activating","Gcg","P06883","UNIPROT","","","","Rattus norvegicus","PC-12 cell","BTO:0001009","oxidative stress","Our data show that GLP-1 activated the mTOR/GCLc pathway.","The text does not provide a lot of detail, but it does say that GLP-1 activates the mTOR pathway and it gives no suggestion that it is not direct",""
+"mTOR signaling pathway","Insulin signaling pathway","GLP-1 mTOR Pathway","19463904","no","no","","","","","","","","","","","","","There only seemed to be an effect on mTOR by GLP-1",""
+"Insulin signaling pathway","Adipocytokine signaling pathway","GLP-1 Adipocytokine Pathway","23670349","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of adipcytokine in the abstract",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","GLP-1 Adipocytokine Pathway","23670349","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of adipcytokine in the abstract",""
+"Insulin signaling pathway","Adipocytokine signaling pathway","GLP-1 Leptin Cross-talk","22474124","no","no","","","","","","","","","","","","","The text suggests a relationship, but does not ever give evidence or describe any interactions",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","GLP-1 Leptin Cross-talk","22474124","no","no","","","","","","","","","","","","","The text suggests a relationship, but does not ever give evidence or describe any interactions",""
+"Insulin signaling pathway","Adipocytokine signaling pathway","GLP-1 Leptin Cross-talk","9225821","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that leptin is not affected by GLP-1 in this context",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","GLP-1 Leptin Cross-talk","9225821","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that leptin is not affected by GLP-1 in this context",""
+"Insulin signaling pathway","Adipocytokine signaling pathway","GLP-1 Leptin Cross-talk","24672981","no","no","","","","","","","","","","","","","The text was written in French so it could not be read",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","GLP-1 Leptin Cross-talk","24672981","no","no","","","","","","","","","","","","","The text was written in French so it could not be read",""
+"Insulin signaling pathway","Adipocytokine signaling pathway","GLP-1 Leptin Pathway","25833771","no","no","","","","","","","","","","","","","There only seemed to be an effect on GLP-1 by leptin",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","GLP-1 Leptin Pathway","25833771","yes","no","activating","LEP","P41159","UNIPROT","GCG","P01275","UNIPROT","Homo sapiens","neuron","BTO:0000938","obesity/anorexia","Specifically, leptin has been demonstrated to interact with GLP-1 and its receptor antagonist to induce satiation","The text does not give any detail but it does state that leptin interacts with GLP-1",""
+"Insulin signaling pathway","Adipocytokine signaling pathway","GLP-1 Leptin Pathway","24222040","no","no","","","","","","","","","","","","","The text suggests that leptin and GLP-1 interact, but it mainly just discusses the effect of coinjecting leptin and GLP-1, and does not actually provide any evidence for interactions",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","GLP-1 Leptin Pathway","24222040","no","no","","","","","","","","","","","","","The text suggests that leptin and GLP-1 interact, but it mainly just discusses the effect of coinjecting leptin and GLP-1, and does not actually provide any evidence for interactions",""
+"Insulin signaling pathway","ErbB signaling pathway","GLP-1 EGFR Pathway","23147408","yes","yes","activating","Gcg","P06883","UNIPROT","Egfr","G3V6K6","UNIPROT","Rattus norvegicus","PC-12 cell","BTO:0001009","diabetes","In the present study, we first demonstrated that GLP-1 protected PC12 cells from MG-induced apoptosis via EGFR transactivation and subsequent activation of the PI3K/Akt/mTOR/GCLc/redox signaling pathway.","The text describes a lot of effects that GLP-1 has on EGFR and mTOR, but it explains that all of those effects are results of transactivation of EGFR. The text was only available through the library and is saved",""
+"ErbB signaling pathway","Insulin signaling pathway","GLP-1 EGFR Pathway","23147408","no","no","","","","","","","","","","","","","There only seemed to be an effect on EGFR by GLP-1. The text was only available through the library and is saved",""
+"Insulin signaling pathway","ErbB signaling pathway","GLP-1 EGFR Pathway","12502502","yes","yes","activating","Gcg","P55095","UNIPROT","Btc","Q05928","UNIPROT","Mus musculus","pancreas","BTO:0000988","proliferation","These results are consistent with the view that GLP-1 induces EGFR transactivation via the production of BTC, although we cannot exclude at this stage the possibility that other EGF-like ligands participate in this process.","The text was not very clear when explaining the effect of GLP-1 on EGFR, but there was no concrete evidence of direct interactions. It seems that GLP-1 activates the production of BTC and that somehow transactivates EGFR. The text also suggests a role for c-Src, but did not explain it well at all and made it to ambiguous",""
+"ErbB signaling pathway","Insulin signaling pathway","GLP-1 EGFR Pathway","12502502","no","no","","","","","","","","","","","","","There only seemed to be an effect on EGFR by GLP-1",""
+"Insulin signaling pathway","ErbB signaling pathway","GLP-1 EGFR Pathway","25544681","no","no","","","","","","","","","","","","","The full text was not read because EGFR was only briefly mentioned and in a different context than GLP-1",""
+"ErbB signaling pathway","Insulin signaling pathway","GLP-1 EGFR Pathway","25544681","no","no","","","","","","","","","","","","","The full text was not read because EGFR was only briefly mentioned and in a different context than GLP-2",""
+"Insulin signaling pathway","ErbB signaling pathway","Glucagon EGFR Pathway","22895780","yes","yes","activating","","","","","","","Mus musculus","colon","BTO:0000269","normal","Further evidence of the specificity of the GLP-2 response in enteric neurons is shown by the remarkable increases in the ErbB family of receptors and ligands following GLP-2 stimulation.","The text explains a transcriptional effect on the ErbB receptors, but since there is no mechanism provided, the crosstalk is unclear",""
+"ErbB signaling pathway","Insulin signaling pathway","Glucagon EGFR Pathway","22895780","no","no","","","","","","","","","","","","","There only seemed to be an effect on ErbB by GLP-2",""
+"Insulin signaling pathway","ErbB signaling pathway","Glucagon EGFR Pathway","21126059","no","no","","","","","","","","","","","","","The full text was not read because glucagon was not mentioned in the abstract",""
+"ErbB signaling pathway","Insulin signaling pathway","Glucagon EGFR Pathway","21126059","no","no","","","","","","","","","","","","","The full text was not read because glucagon was not mentioned in the abstract",""
+"Insulin signaling pathway","Estrogen signaling pathway","GLP-1 Estrogen Pathway","17558182","no","no","","","","","","","","","","","","","The text suggests a relationship, but was too ambiguous and didn't give enough detail",""
+"Estrogen signaling pathway","Insulin signaling pathway","GLP-1 Estrogen Pathway","17558182","no","no","","","","","","","","","","","","","The text suggests a relationship, but was too ambiguous and didn't give enough detail",""
+"Insulin signaling pathway","Estrogen signaling pathway","GIP Estrogen Pathway","12176662","no","no","","","","","","","","","","","","","The full text was not read because estrogen was not mentioned in the abstract",""
+"Estrogen signaling pathway","Insulin signaling pathway","GIP Estrogen Pathway","12176662","no","no","","","","","","","","","","","","","The full text was not read because estrogen was not mentioned in the abstract",""
+"Insulin signaling pathway","Estrogen signaling pathway","Glucagon Estrogen Crosstalk","8011424","no","no","","","","","","","","","","","","","The full text was not read because estrogen was not mentioned in the abstract",""
+"Estrogen signaling pathway","Insulin signaling pathway","Glucagon Estrogen Crosstalk","8011424","no","no","","","","","","","","","","","","","The full text was not read because estrogen was not mentioned in the abstract",""
+"Insulin signaling pathway","Estrogen signaling pathway","Glucagon Estrogen Cross-talk","19627176","no","no","","","","","","","","","","","","","The full article was not read because the abstract on mentioned each pathway regulating something else, but not each other",""
+"Estrogen signaling pathway","Insulin signaling pathway","Glucagon Estrogen Cross-talk","19627176","no","no","","","","","","","","","","","","","The full article was not read because the abstract on mentioned each pathway regulating something else, but not each other",""
+"Insulin signaling pathway","Estrogen signaling pathway","Glucagon Estrogen Pathway","23371010","no","no","","","","","","","","","","","","","The text suggests that glucagon has an effect on estrogen, but the relationship described is indirect",""
+"Estrogen signaling pathway","Insulin signaling pathway","Glucagon Estrogen Pathway","23371010","no","no","","","","","","","","","","","","","The text suggests that glucagon has an effect on estrogen, but the relationship described is indirect",""
+"Insulin signaling pathway","GnRH signaling pathway","GLP-1 GnRH Pathway","24912407","no","no","","","","","","","","","","","","","The abstract suggests crosstalk, but there is none described in the text",""
+"GnRH signaling pathway","Insulin signaling pathway","GLP-1 GnRH Pathway","24912407","no","no","","","","","","","","","","","","","The abstract suggests crosstalk, but there is none described in the text",""
+"Insulin signaling pathway","GnRH signaling pathway","Glucagon GnRH Pathway","7915230","no","no","","","","","","","","","","","","","The only relationship described between PACAP and GnRH is indirect. The full article was not available through PubMed but was available through the library and has been saved",""
+"GnRH signaling pathway","Insulin signaling pathway","Glucagon GnRH Pathway","7915230","no","no","","","","","","","","","","","","","The only relationship described between PACAP and GnRH is indirect. The full article was not available through PubMed but was available through the library and has been saved",""
+"Insulin signaling pathway","GnRH signaling pathway","PACAP GnRH Cross-talk","7515005","no","no","","","","","","","","","","","","","The only relationship described between PACAP and GnRH is indirect. The full article was not available through PubMed but was available through the library and has been saved",""
+"GnRH signaling pathway","Insulin signaling pathway","PACAP GnRH Cross-talk","7515005","no","no","","","","","","","","","","","","","The only relationship described between PACAP and GnRH is indirect. The full article was not available through PubMed but was available through the library and has been saved",""
+"Insulin signaling pathway","GnRH signaling pathway","PACAP GnRH Cross-talk","9165009","no","no","","","","","","","","","","","","","The full text was not read because in the abstract both pathways were mentioned in a different context",""
+"GnRH signaling pathway","Insulin signaling pathway","PACAP GnRH Cross-talk","9165009","no","no","","","","","","","","","","","","","The full text was not read because in the abstract both pathways were mentioned in a different context",""
+"Insulin signaling pathway","GnRH signaling pathway","PACAP GnRH Cross-talk","16888195","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned how each pathway has an effect on cAMP production",""
+"GnRH signaling pathway","Insulin signaling pathway","PACAP GnRH Cross-talk","16888195","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned how each pathway has an effect on cAMP production",""
+"Insulin signaling pathway","HIF-1 signaling pathway","GLP-1 HIF-1 Pathway","24705496","no","no","","","","","","","","","","","","","The text suggests a relationship between HIF-1 and GLP-1, but there is no evidence of any interactions",""
+"HIF-1 signaling pathway","Insulin signaling pathway","GLP-1 HIF-1 Pathway","24705496","no","no","","","","","","","","","","","","","The text suggests a relationship between HIF-1 and GLP-1, but there is no evidence of any interactions",""
+"Insulin signaling pathway","HIF-1 signaling pathway","GLP-1 HIF-1 Pathway","21949366","no","no","","","","","","","","","","","","","The full text was not read because the abstract mainly discusses relationships with mTOR",""
+"HIF-1 signaling pathway","Insulin signaling pathway","GLP-1 HIF-1 Pathway","21949366","no","no","","","","","","","","","","","","","The full text was not read because the abstract mainly discusses relationships with mTOR",""
+"Insulin signaling pathway","HIF-1 signaling pathway","GLP-1 HIF-1 Pathway","19050081","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that the study being performed is independent of HIF-1",""
+"HIF-1 signaling pathway","Insulin signaling pathway","GLP-1 HIF-1 Pathway","19050081","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that the study being performed is independent of HIF-2",""
+"Insulin signaling pathway","HIF-1 signaling pathway","GIP HIF-1 Pathway","25537494","no","no","","","","","","","","","","","","","The text mainly describes a correlation between GIP and HIF-1 levels, but no interactions",""
+"HIF-1 signaling pathway","Insulin signaling pathway","GIP HIF-1 Pathway","25537494","no","no","","","","","","","","","","","","","The text mainly describes a correlation between GIP and HIF-1 levels, but no interactions",""
+"Insulin signaling pathway","HIF-1 signaling pathway","Glucagon HIF-1 Cross-talk","12213585","no","no","","","","","","","","","","","","","The full paper was not read because in the abstract both pathways were mention in a different context",""
+"HIF-1 signaling pathway","Insulin signaling pathway","Glucagon HIF-1 Cross-talk","12213585","no","no","","","","","","","","","","","","","The full paper was not read because in the abstract both pathways were mention in a different context",""
+"Insulin signaling pathway","Hippo signaling pathway","Glucagon Hippo Pathway","22863277","no","no","","","","","","","","","","","","","The text suggests a relationship, but it is too ambiguous to determine crosstalk",""
+"Hippo signaling pathway","Insulin signaling pathway","Glucagon Hippo Pathway","22863277","no","no","","","","","","","","","","","","","The text suggests a relationship, but it is too ambiguous to determine crosstalk",""
+"Insulin signaling pathway","Hippo signaling pathway","CCK Hippo Pathway","25373346","no","no","","","","","","","","","","","","","The full text was not read because in the abstract CCK means cell counting kit",""
+"Hippo signaling pathway","Insulin signaling pathway","CCK Hippo Pathway","25373346","no","no","","","","","","","","","","","","","The full text was not read because in the abstract CCK means cell counting kit",""
+"Insulin signaling pathway","Hippo signaling pathway","CCK Hippo Pathway","24356001","no","no","","","","","","","","","","","","","The full text was not read because in the abstract CCK means cell counting kit",""
+"Hippo signaling pathway","Insulin signaling pathway","CCK Hippo Pathway","24356001","no","no","","","","","","","","","","","","","The full text was not read because in the abstract CCK means cell counting kit",""
+"Insulin signaling pathway","Hippo signaling pathway","CCK Hippo Pathway","25175178","no","no","","","","","","","","","","","","","The full text was not read because in the abstract CCK means cell counting kit",""
+"Hippo signaling pathway","Insulin signaling pathway","CCK Hippo Pathway","25175178","no","no","","","","","","","","","","","","","The full text was not read because in the abstract CCK means cell counting kit",""
+"Insulin signaling pathway","Hippo signaling pathway","CCK YAP Pathway","24708221","no","no","","","","","","","","","","","","","The full article was not read because in the abstract CCK means comfort care kit and Yap is the name of an author",""
+"Hippo signaling pathway","Insulin signaling pathway","CCK YAP Pathway","24708221","no","no","","","","","","","","","","","","","The full article was not read because in the abstract CCK means comfort care kit and Yap is the name of an author",""
+"Insulin signaling pathway","Insulin secretion pathway","GLP-1 Insulin Crosstalk","25843210","no","no","","","","","","","","","","","","","The article only discusses GLP-1 secretion and insulin secretion, but not the 2 separate pathways interacting",""
+"Insulin signaling pathway","Insulin secretion pathway","GLP-1 Insulin Crosstalk","23314196","no","no","","","","","","","","","","","","","The full text was not read because the abstract mainly discusses diabetes, and didn't give any indication that the insulin secretion pathway and the insulin signaling pathway interact",""
+"Insulin signaling pathway","Jak-STAT signaling pathway","GLP-1 Jak-STAT Pathway","16216905","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context",""
+"Jak-STAT signaling pathway","Insulin signaling pathway","GLP-1 Jak-STAT Pathway","16216905","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context",""
+"Insulin signaling pathway","Jak-STAT signaling pathway","GIP Jak-STAT Pathway","24081222","no","no","","","","","","","","","","","","","The full article was not read because both pathways were only mentioned as having a role in appetite regulation, but they were not suggested to have any interactions",""
+"Jak-STAT signaling pathway","Insulin signaling pathway","GIP Jak-STAT Pathway","24081222","no","no","","","","","","","","","","","","","The full article was not read because both pathways were only mentioned as having a role in appetite regulation, but they were not suggested to have any interactions",""
+"Insulin signaling pathway","Jak-STAT signaling pathway","Cholecystokinin Jak-STAT Pathway","23170143","yes","no","activating","Cck","P09240","UNIPROT","","","","Mus musculus","pancreas","BTO:0000988","cancer","CCK2 receptor (CCK2R) upon binding of CCK activated the JAK2/STAT3 pathway in pancreatic acini in transgenic mice expressing CCK2R.","The text does not provide a lot of evidence or details but it does say that CCK activates Jak-STAT, and doesn't give an indication that it is indirect",""
+"Jak-STAT signaling pathway","Insulin signaling pathway","Cholecystokinin Jak-STAT Pathway","23170143","no","no","","","","","","","","","","","","","There only seemed to be an effect on Jak-STAT by CCK",""
+"Insulin signaling pathway","Jak-STAT signaling pathway","Cholecystokinin Jak-STAT Pathway","24407606","no","no","","","","","","","","","","","","","The full paper was not read because in the abstract both pathways were discussed in a different context",""
+"Jak-STAT signaling pathway","Insulin signaling pathway","Cholecystokinin Jak-STAT Pathway","24407606","no","no","","","","","","","","","","","","","The full paper was not read because in the abstract both pathways were discussed in a different context",""
+"Insulin signaling pathway","Jak-STAT signaling pathway","Cholecystokinin Jak-STAT Pathway","23197703","no","no","","","","","","","","","","","","","The full text was not read because CCK was not mentioned in the abstract",""
+"Jak-STAT signaling pathway","Insulin signaling pathway","Cholecystokinin Jak-STAT Pathway","23197703","no","no","","","","","","","","","","","","","The full text was not read because CCK was not mentioned in the abstract",""
+"Insulin signaling pathway","MAPK signaling pathway","GCG MAPK Pathway","24587221","no","no","","","","","","","","","","","","","The text suggests a relationship, but is too ambiguous to determine crosstalk",""
+"MAPK signaling pathway","Insulin signaling pathway","GCG MAPK Pathway","24587221","no","no","","","","","","","","","","","","","The text suggests a relationship, but is too ambiguous to determine crosstalk",""
+"Insulin signaling pathway","MAPK signaling pathway","GLP-1 MAPK Crosstalk","17065399","no","no","","","","","","","","","","","","","The text mainly discussed how each pathway interacts with meat hydrolysate and not each other",""
+"MAPK signaling pathway","Insulin signaling pathway","GLP-1 MAPK Crosstalk","17065399","no","no","","","","","","","","","","","","","The text mainly discussed how each pathway interacts with meat hydrolysate and not each other",""
+"Insulin signaling pathway","MAPK signaling pathway","GLP-1 MAPK Pathway","24912407","no","no","","","","","","","","","","","","","The article mainly talked about each pathway being important and reacting in similar ways to the experiment, but it does not say that they interact",""
+"MAPK signaling pathway","Insulin signaling pathway","GLP-1 MAPK Pathway","24912407","no","no","","","","","","","","","","","","","The article mainly talked about each pathway being important and reacting in similar ways to the experiment, but it does not say that they interact",""
+"Insulin signaling pathway","MAPK signaling pathway","GLP-1 MAPK Pathway","22907305","no","no","","","","","","","","","","","","","The full article was not read because it was written in chinese. The abstract did suggest a relationship, but it seemed to be an indirect one",""
+"MAPK signaling pathway","Insulin signaling pathway","GLP-1 MAPK Pathway","22907305","no","no","","","","","","","","","","","","","The full article was not read because it was written in chinese. The abstract did suggest a relationship, but it seemed to be an indirect one",""
+"Insulin signaling pathway","MAPK signaling pathway","GLP-1 MAPK Pathway","23611362","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses how each pathway interacts with chitosan not each other",""
+"MAPK signaling pathway","Insulin signaling pathway","GLP-1 MAPK Pathway","23611362","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses how each pathway interacts with chitosan not each other",""
+"Insulin signaling pathway","MAPK signaling pathway","GLP-1 MAPK Pathway","23900416","no","no","","","","","","","","","","","","","The text suggests a relationship/crosstalk, but all the interactions described seem indirect",""
+"MAPK signaling pathway","Insulin signaling pathway","GLP-1 MAPK Pathway","23900416","no","no","","","","","","","","","","","","","The text suggests a relationship/crosstalk, but all the interactions described seem indirect",""
+"Insulin signaling pathway","Neurotrophin signaling pathway","GLP-1 Neurotrophin Pathway","25862329","no","no","","","","","","","","","","","","","The full text was not read because Neurotrophin was not mentioned in the abstract",""
+"Neurotrophin signaling pathway","Insulin signaling pathway","GLP-1 Neurotrophin Pathway","25862329","no","no","","","","","","","","","","","","","The full text was not read because Neurotrophin was not mentioned in the abstract",""
+"Insulin signaling pathway","Neurotrophin signaling pathway","Glucagon Neurotrophin Pathway","23243234","no","no","","","","","","","","","","","","","The full article was not read because both pathways were mentioned in a different context in the abstract",""
+"Neurotrophin signaling pathway","Insulin signaling pathway","Glucagon Neurotrophin Pathway","23243234","no","no","","","","","","","","","","","","","The full article was not read because both pathways were mentioned in a different context in the abstract",""
+"Insulin signaling pathway","Neurotrophin signaling pathway","GLP-1 BDNF Pathway","23020846","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were mentioned in a different context in the abstract",""
+"Neurotrophin signaling pathway","Insulin signaling pathway","GLP-1 BDNF Pathway","23020846","no","no","","","","","","","","","","","","","The full paper was not read because both pathways were mentioned in a different context in the abstract",""
+"Insulin signaling pathway","Neurotrophin signaling pathway","GLP-1 BDNF Pathway","25543463","no","no","","","","","","","","","","","","","The abstract suggested potential crosstalk but there was no evidence of any interaction in the text",""
+"Neurotrophin signaling pathway","Insulin signaling pathway","GLP-1 BDNF Pathway","25543463","no","no","","","","","","","","","","","","","The abstract suggested potential crosstalk but there was no evidence of any interaction in the text",""
+"Insulin signaling pathway","Neurotrophin signaling pathway","PACAP Neurotrophin Pathway","24726470","no","no","","","","","","","","","","","","","The full paper was not read because Neurotrophin was not mentioned in the abstract",""
+"Neurotrophin signaling pathway","Insulin signaling pathway","PACAP Neurotrophin Pathway","24726470","no","no","","","","","","","","","","","","","The full paper was not read because Neurotrophin was not mentioned in the abstract",""
+"Insulin signaling pathway","NF-kappa B signaling pathway","GLP-1 NF-kappa B Cross-talk","25109805","no","no","","","","","","","","","","","","","The full text was not read because NF-kappa B was not mentioned in the abstract",""
+"NF-kappa B signaling pathway","Insulin signaling pathway","GLP-1 NF-kappa B Cross-talk","25109805","no","no","","","","","","","","","","","","","The full text was not read because NF-kappa B was not mentioned in the abstract",""
+"Insulin signaling pathway","NF-kappa B signaling pathway","GLP-1 NF-kappa B Pathway","23670349","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that there is not a correlation between GLP-1 and NFkB",""
+"NF-kappa B signaling pathway","Insulin signaling pathway","GLP-1 NF-kappa B Pathway","23670349","no","no","","","","","","","","","","","","","The full article was not read because the abstract states that there is not a correlation between GLP-1 and NFkB",""
+"Insulin signaling pathway","NF-kappa B signaling pathway","GLP-1 NF-kappa B Pathway","22750392","no","no","","","","","","","","","","","","","The text suggests crosstalk but is too ambiguous and does not give any evidence/details",""
+"NF-kappa B signaling pathway","Insulin signaling pathway","GLP-1 NF-kappa B Pathway","22750392","no","no","","","","","","","","","","","","","The text suggests crosstalk but is too ambiguous and does not give any evidence/details",""
+"Insulin signaling pathway","NF-kappa B signaling pathway","GLP-1 NF-kappa B Pathway","25215431","yes","no","inhibiting","Gcg","P06883","UNIPROT","Nfkb1","Q63369","UNIPROT","Rattus norvegicus","kidney","BTO:0000671","diabetes","The results indicated that the NF-kappa B pathway is activated in diabetic nephropathy and liraglutide(GLP-1) is able to suppress p65 expression and phosphorylation on serine 276 of NF-kB.","The text states that GLP-1 prevents the phosphorylation of NF-kB",""
+"Insulin signaling pathway","NF-kappa B signaling pathway","GLP-1 NF-kappa B Pathway","25215431","yes","yes","inhibiting","Gcg","P06883","UNIPROT","Rela","Q7TQN4","UNIPROT","Rattus norvegicus","kidney","BTO:0000671","diabetes","The results indicated that the NF-kappa B pathway is activated in diabetic nephropathy and liraglutide(GLP-1) is able to suppress p65 expression and phosphorylation on serine 276 of NF-kB.","The text states that GLP-1 suppresses the expression of p65, and while no specific mechanism is provided, there is no suggestion of any indirect effects on p65",""
+"NF-kappa B signaling pathway","Insulin signaling pathway","GLP-1 NF-kappa B Pathway","25215431","no","no","","","","","","","","","","","","","There was no crosstalk described from NF-kappa B to Insulin secretion",""
+"Insulin signaling pathway","NF-kappa B signaling pathway","GLP-1 NF-kappa B Pathway","25407893","yes","yes","inhibiting","GLP1R","P43220","UNIPROT","TNFSF11","O14788","UNIPROT","Homo sapiens","vascular smooth muscle cell","BTO:0004578","calcifying","The present study showed that exenatide inhibited RANKL expression in human CVSMCs through the NF-κB pathway and mitigated CVSMCs calcification.","The crosstalk seems transcriptional since the sentence says that exenatide inhibited RANKL expression, but since there is a claim that this is done through the NFkB pathway, there may be regular crosstalk as well, but the subject is not discussed further in the text",""
+"NF-kappa B signaling pathway","Insulin signaling pathway","GLP-1 NF-kappa B Pathway","25407893","no","no","","","","","","","","","","","","","There only seemed to be an effect on NF-kappa by GLP-1R",""
+"Insulin signaling pathway","NF-kappa B signaling pathway","GLP-1 NF-kappa B Pathway","20593161","no","no","","","","","","","","","","","","","The text was too ambiguous and did not provide enough detail to determine crosstalk",""
+"NF-kappa B signaling pathway","Insulin signaling pathway","GLP-1 NF-kappa B Pathway","20593161","no","no","","","","","","","","","","","","","The text was too ambiguous and did not provide enough detail to determine crosstalk",""
+"Insulin signaling pathway","Prolactin signaling pathway","GLP-1 Prolactin Pathway","16216905","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Prolactin signaling pathway","Insulin signaling pathway","GLP-1 Prolactin Pathway","16216905","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Insulin signaling pathway","Prolactin signaling pathway","Glucagon Prolactin Pathway","11850439","no","no","","","","","","","","","","","","","The full article was not read because glucagon was not mentioned in the abstract",""
+"Prolactin signaling pathway","Insulin signaling pathway","Glucagon Prolactin Pathway","11850439","no","no","","","","","","","","","","","","","The full article was not read because glucagon was not mentioned in the abstract",""
+"Insulin signaling pathway","Prolactin signaling pathway","Glucagon Prolactin Pathway","591612","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentions each pathway reacting to drugs, not each other",""
+"Prolactin signaling pathway","Insulin signaling pathway","Glucagon Prolactin Pathway","591612","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentions each pathway reacting to drugs, not each other",""
+"Insulin signaling pathway","Prolactin signaling pathway","Glucagon Prolactin Pathway","8822270","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses the respone of each pathway to heparin, not each other",""
+"Prolactin signaling pathway","Insulin signaling pathway","Glucagon Prolactin Pathway","8822270","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses the respone of each pathway to heparin, not each other",""
+"Insulin signaling pathway","Prolactin signaling pathway","Glucagon Prolactin Pathway","6361207","no","no","","","","","","","","","","","","","The full paper was not read because each pathway was only mentioned as being involved with chloride cells, not each other",""
+"Prolactin signaling pathway","Insulin signaling pathway","Glucagon Prolactin Pathway","6361207","no","no","","","","","","","","","","","","","The full paper was not read because each pathway was only mentioned as being involved with chloride cells, not each other",""
+"Insulin signaling pathway","TGF-beta signaling pathway","GCG TGF-beta Pathway","17634527","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses how each pathway is involved with Wnt",""
+"TGF-beta signaling pathway","Insulin signaling pathway","GCG TGF-beta Pathway","17634527","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses how each pathway is involved with Wnt",""
+"Insulin signaling pathway","TGF-beta signaling pathway","GLP-1 TGF-beta Cross-talk","16020542","no","no","","","","","","","","","","","","","The full article was not read because the article only discusses how each pathway interacts with BMP",""
+"TGF-beta signaling pathway","Insulin signaling pathway","GLP-1 TGF-beta Cross-talk","16020542","no","no","","","","","","","","","","","","","The full article was not read because the article only discusses how each pathway interacts with BMP",""
+"Insulin signaling pathway","TGF-beta signaling pathway","GLP-1 TGF-beta Pathway","22483938","no","no","","","","","","","","","","","","","The full paper was not read because GLP-1 was not mentioned in the abstract",""
+"TGF-beta signaling pathway","Insulin signaling pathway","GLP-1 TGF-beta Pathway","22483938","no","no","","","","","","","","","","","","","The full paper was not read because GLP-1 was not mentioned in the abstract",""
+"Insulin signaling pathway","TGF-beta signaling pathway","GLP-1 TGF-beta Pathway","22890152","yes","yes","inhibiting","","","","","","","Homo sapiens","kidney","BTO:0000671","diabetes","Our results show that addition of either 0.3 or 3 nmol/l Ex-4 decreases the mRNA and protein levels of TGF-beta and CTGF","Although a mechanism is not provided, the text does say that Ex-4 causes a decrease in protein levels",""
+"TGF-beta signaling pathway","Insulin signaling pathway","GLP-1 TGF-beta Pathway","22890152","no","no","","","","","","","","","","","","","There only seemed to be an effect on TGF-beta by GLP-1",""
+"Insulin signaling pathway","TGF-beta signaling pathway","GLP-1 TGF-beta Pathway","16025000","no","no","","","","","","","","","","","","","The text describes a potential relationship between the pathways but provides no evidence of interactions",""
+"TGF-beta signaling pathway","Insulin signaling pathway","GLP-1 TGF-beta Pathway","16025000","no","no","","","","","","","","","","","","","The text describes a potential relationship between the pathways but provides no evidence of interactions",""
+"Insulin signaling pathway","TNF signaling pathway","GLP-1 TNF Pathway","25149084","yes","yes","activating","Prkaca","P05132","UNIPROT","C1qtnf3","Q9ES30","UNIPROT","Mus musculus","adipocyte","BTO:0000443","normal","This study found that Ex-4 increased the expression of CTRP3, a novel adipokines, in 3T3-L1 adipocytes through GLP-1 receptor","The text states that there is a transcriptional effect on CTRP3, but the text explains later in the paper that this is through PKA. The full article was not available through PubMed but was available through the library and has been saved",""
+"TNF signaling pathway","Insulin signaling pathway","GLP-1 TNF Pathway","25149084","no","no","","","","","","","","","","","","","There only seemed to be an effect on TNF by GLP-1",""
+"Insulin signaling pathway","TNF signaling pathway","GLP-1 TNF Pathway","21239158","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"TNF signaling pathway","Insulin signaling pathway","GLP-1 TNF Pathway","21239158","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Insulin signaling pathway","TNF signaling pathway","GLP-1 TNF Pathway","24335838","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentions a relationship between GLP-1 and NFkB, not TNF",""
+"TNF signaling pathway","Insulin signaling pathway","GLP-1 TNF Pathway","24335838","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentions a relationship between GLP-1 and NFkB, not TNF",""
+"Insulin signaling pathway","TNF signaling pathway","GLP-1 TNF Pathway","24493833","no","no","","","","","","","","","","","","","The full paper was not read because TNF was not mentioned in the abstract",""
+"TNF signaling pathway","Insulin signaling pathway","GLP-1 TNF Pathway","24493833","no","no","","","","","","","","","","","","","The full paper was not read because TNF was not mentioned in the abstract",""
+"Insulin signaling pathway","TNF signaling pathway","GLP-1 TNF Pathway","18487229","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"TNF signaling pathway","Insulin signaling pathway","GLP-1 TNF Pathway","18487229","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Insulin signaling pathway","TNF signaling pathway","GLP-1 TNF Pathway","18475052","no","no","","","","","","","","","","","","","The only relationship described between the two pathways was indirect and there was no mention of any direct interactions or effects",""
+"TNF signaling pathway","Insulin signaling pathway","GLP-1 TNF Pathway","18475052","no","no","","","","","","","","","","","","","The only relationship described between the two pathways was indirect and there was no mention of any direct interactions or effects",""
+"Insulin signaling pathway","TNF signaling pathway","GLP-1 TNF Pathway","17992607","no","no","","","","","","","","","","","","","The full text was not read because TNF-alpha is not mentioned to have any interactions with anything in the abstract",""
+"TNF signaling pathway","Insulin signaling pathway","GLP-1 TNF Pathway","17992607","no","no","","","","","","","","","","","","","The full text was not read because TNF-alpha is not mentioned to have any interactions with anything in the abstract",""
+"Insulin signaling pathway","Toll-like receptor signaling pathway","GCG Toll-like receptor Pathway","20877565","no","no","","","","","","","","","","","","","The full text was not read because GCG in the abstract is EGCG and it means epigallocatechin gallate",""
+"Toll-like receptor signaling pathway","Insulin signaling pathway","GCG Toll-like receptor Pathway","20877565","no","no","","","","","","","","","","","","","The full text was not read because GCG in the abstract is EGCG and it means epigallocatechin gallate",""
+"Insulin signaling pathway","Toll-like receptor signaling pathway","GLP-1 Toll-like receptor Pathway","25022544","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentions how each pathway reacts to DPP-4",""
+"Toll-like receptor signaling pathway","Insulin signaling pathway","GLP-1 Toll-like receptor Pathway","25022544","no","no","","","","","","","","","","","","","The full article was not read because the abstract only mentions how each pathway reacts to DPP-5",""
+"Insulin signaling pathway","Toll-like receptor signaling pathway","GLP-1 Toll-like receptor Pathway","19357791","no","no","","","","","","","","","","","","","The full paper was not read because GLP-1 is not mentioned in the abstract",""
+"Toll-like receptor signaling pathway","Insulin signaling pathway","GLP-1 Toll-like receptor Pathway","19357791","no","no","","","","","","","","","","","","","The full paper was not read because GLP-1 is not mentioned in the abstract",""
+"Insulin signaling pathway","Toll-like receptor signaling pathway","GLP-1 Toll-like receptor Pathway","23157357","no","no","","","","","","","","","","","","","The full paper was not read because neither pathway was mentioned in the abstract",""
+"Toll-like receptor signaling pathway","Insulin signaling pathway","GLP-1 Toll-like receptor Pathway","23157357","no","no","","","","","","","","","","","","","The full paper was not read because neither pathway was mentioned in the abstract",""
+"Insulin signaling pathway","Toll-like receptor signaling pathway","PACAP Toll-like receptor Pathway","25821833","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Toll-like receptor signaling pathway","Insulin signaling pathway","PACAP Toll-like receptor Pathway","25821833","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Insulin signaling pathway","VEGF signaling pathway","GLP-1 VEGF Pathway","24349326","no","no","","","","","","","","","","","","","The text indicated that GLP-1 has a transcriptional effect on VEGF, but kept alternating between saying it affects expression and that it affects secretion, and they were said in the same context so it is most likely not both. The crosstalk is too ambiguous",""
+"VEGF signaling pathway","Insulin signaling pathway","GLP-1 VEGF Pathway","24349326","no","no","","","","","","","","","","","","","The text indicated that GLP-1 has a transcriptional effect on VEGF, but kept alternating between saying it affects expression and that it affects secretion, and they were said in the same context so it is most likely not both. The crosstalk is too ambiguous",""
+"Insulin signaling pathway","VEGF signaling pathway","GLP-1 VEGF Pathway","23766261","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"VEGF signaling pathway","Insulin signaling pathway","GLP-1 VEGF Pathway","23766261","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"Insulin signaling pathway","VEGF signaling pathway","Glucagon VEGF Pathway","25222223","no","no","","","","","","","","","","","","","The full paper was not read because glucagon was only mentioned in the abstract to say that it induces hyperglycemia",""
+"VEGF signaling pathway","Insulin signaling pathway","Glucagon VEGF Pathway","25222223","no","no","","","","","","","","","","","","","The full paper was not read because glucagon was only mentioned in the abstract to say that it induces hyperglycemia",""
+"Insulin signaling pathway","VEGF signaling pathway","Glucagon VEGF Pathway","19238077","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses how each pathway reacts to Von Hippel-Lindau disease",""
+"VEGF signaling pathway","Insulin signaling pathway","Glucagon VEGF Pathway","19238077","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses how each pathway reacts to Von Hippel-Lindau disease",""
+"Insulin signaling pathway","VEGF signaling pathway","Glucagon VEGF Pathway","26006020","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentions both pathways to say that they have significantly increased expression in the human fetal pancreas",""
+"VEGF signaling pathway","Insulin signaling pathway","Glucagon VEGF Pathway","26006020","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentions both pathways to say that they have significantly increased expression in the human fetal pancreas",""
+"Insulin signaling pathway","Wnt signaling pathway","GCG Wnt Crosstalk","19772917","yes","no","activating","PRKACA","P17612","UNIPROT","CTNNB1","P35222","UNIPROT","Homo sapiens","pancreas","BTO:0000988","normal","GLP-1 also stimulated β-cat phosphorylation at Ser675, and this is likely mediated by PKA activation","The sentence given is not completely clear on the crosstalk, but later in the article it clarifies that in pancreatic beta cells the activation of PKA is mainly due to GLP-1, and there is strong evidence given that PKA phosphorylates beta-catenin. The text also discusses some transcriptional crosstalk, but it seems that the transcriptional effects are due to the direct effects",""
+"Wnt signaling pathway","Insulin signaling pathway","GCG Wnt Crosstalk","19772917","no","no","","","","","","","","","","","","","There only seemed to be an effect on Wnt by GLP-1",""
+"Insulin signaling pathway","Wnt signaling pathway","GLP-1 Wnt Crosstalk","22438981","yes","no","activating","Gcgr","Q61606","UNIPROT","Lrp5/Lrp6","Q91VN0/O88572","UNIPROT","Mus musculus","hepatocyte","BTO:0000575","normal","So activation of GCGR upon ligand binding can directly cross-talk to Lrp5/6 to transmit downstream β-catenin signaling whereas phosphorylation and activation of Lrp5/6 on the other hand can communicate back to GCGR to boost GCGR mediated cAMP/PKA pathway","The text states that GCGR and Lrp5/6 directly bind to each other, and that has the effect of activating the beta-catenin pathway. It was also suggested in the text that PKA is likely involved, but did not give any other details",""
+"Wnt signaling pathway","Insulin signaling pathway","GLP-1 Wnt Crosstalk","22438981","yes","no","activating","Lrp5/Lrp6","Q91VN0/O88572","UNIPROT","Gcgr","Q61606","UNIPROT","Mus musculus","hepatocyte","BTO:0000575","normal","Using immunoprecipitation, we found that Lrp5/6 physically interacted with GCGR","The text states that GCGR and Lrp5/6 bind directly, which activates the beta-catenin pathway, but that same interaction can be used to activate the cAMP/PKA pathway, so the crosstalk is bidirectional",""
+"Progesterone-mediated oocyte maturation","Melanogenesis","POMC Progesterone Crosstalk ","2986404","no","","","","","","","","","","","","","","",""
+"Melanogenesis","Progesterone-mediated oocyte maturation","POMC Progesterone Crosstalk","2986404","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","Jak-STAT signaling pathway","adipocytokine AND Jak-STAT","12674509","yes","no","activating","Lep","P50596","UNIPROT","Jak2","Q62689","UNIPROT","Rattus norvegicus","liver","BTO:0000759","","This indicates that there is a positive crosstalk between insulin and leptin signaling pathways at the level of JAK2 and STAT5b in rat liver","",""
+"Adipocytokine signaling pathway","Wnt signaling pathway","adipocytokine AND Wnt","22270359","yes","no","activating","LEP","P41159","UNIPROT","GSK3B","P49841","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","Cancer cells","Leptin increases accumulation and nuclear translocation of B-catenin leading to increased promoter recruitment.","I agree. However, the mechanism consists of leptin inducing Akt phosphorylation of GSK3B, which then breaks apart the desctruction complex",""
+"Adipocytokine signaling pathway","ErbB signaling pathway","adipocytokine AND ErbB","18945363","yes","no","activating","LEP","P41159","UNIPROT","ERBB2","P04626","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","","In MCF-7 cells, HER2 physically interacted with ObR and leptin treatment increased HER2 phosphorylation on Tyr 1248.","",""
+"Adipocytokine signaling pathway","Toll-like receptor signaling pathway","adipocytokine AND Toll-like Receptor","23674516","no","","inhibiting","Adipoq","Q60994","UNIPROT","Tlr4","Q9QUK6","UNIPROT","Mus musculus","cardiac muscle fiber","BTO:0002320","","APN inhibited the expression of a TLR4-mediated inflammatory phenotype induced by exogenous and endogenous TLR4 ligands","",""
+"Adipocytokine signaling pathway","MAPK signaling pathway","adipocytokine AND MAPK AND (crosstalk OR ""cross-talk)","19183933","yes","no","activating","CD40LG","P29965","UNIPROT","MAPK3,MAPK1,MAPK8,MAPK9","P27361,P28482,P45983,P45984","UNIPROT","Homo sapiens","adipose tissue","BTO:0001487","","Addition of rCD40L transiently (within 10–30 min of the addition of rCD40L) increased the phosphorylation of p38, ERK1/2, and JNK1/2 and induced IκB degradation in a time-dependent manner, reaching maximum degradation at 30 min (Fig. 3a).","",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","adipocytokine AND Insulin","19047149","yes","no","activating","LEP","P41159","UNIPROT","IGF1","P05019","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","","We found a novel bidirectional crosstalk between leptin and IGF-I signaling; IGF-I induced phosphorylation of leptin receptor (Ob- Rb) and leptin induced phosphorylation of IGF-I receptor (IGF-IR)","",""
+"Adipocytokine signaling pathway","Insulin signaling pathway","adipocytokine AND Insulin","19183933","yes","no","inhibiting","LEP","P41159","UNIPROT","IRS1","P35568","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","","We found a novel bidirectional crosstalk between leptin and IGF-I signaling; IGF-I induced phosphorylation of leptin receptor (Ob- Rb) and leptin induced phosphorylation of IGF-I receptor (IGF-IR)","",""
+"Adipocytokine signaling pathway","TNF signaling pathway","adipocytokine AND TNF","19183933","yes","no","activating","CD40LG","P29965","UNIPROT","TNF","P01375","UNIPROT","Homo sapiens","adipose tissue","BTO:0001487","","share receptor","Looks like Adipocytokine pathway results in increased expression of TNFa and other inflammatory ligands",""
+"Adipocytokine signaling pathway","VEGF signaling pathway","adipocytokine AND VEGF","25230157","yes","yes","activating","LEPR","P48357","UNIPROT","JUN","P05412","UNIPROT","Homo sapiens","endothelial progenitor cell","BTO:0004093","","Leptin increases VEGF production by activating OBRl receptor and MAPKs (p38, ERK, and JNK), which in turn enhances binding of AP-1 transcription factor to VEGF promoter, resulting in the transactivation of VEGF expression and subsequently promoting migration and tube formation in endothelial progenitor cells (EPCs).","Transcriptional",""
+"Adipocytokine signaling pathway","Estrogen signaling pathway","adipocytokine AND Estrogen","20410173","yes","no","activating","LEP","P41159","UNIPROT","ESR1","P03372","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","","on MCF 7 cells, rleptin induced a strong phosphorylation of the signal transducer and activator of transcription (STAT) 3 and of the extracellular related kinase 1/2 pathways with an increased cell viability and proliferation associated with an increased expression of ERalpha receptor","neutralization and/or inactivation of LepR inhibits proliferation and viability of human breast cancer cell lines",""
+"Adipocytokine signaling pathway","NF-kappa B signaling pathway","adipocytokine AND NF kappa B","23765438","yes","no","activating","Retn","Q8K4J7","UNIPROT","Nfkb1","Q63369","UNIPROT","Rattus norvegicus","AR4-2J cell","BTO:0001928","","Resistin exhibits some cytotoxic activity in rat pancreatic acinar AR42J cells and stimulates proinflammatory cytokine TNFa and IL-6 production via NF-kB activation.","",""
+"Neurotrophin signaling pathway","Jak-STAT signaling pathway","Neurotrophin AND Jak-STAT","16942527","yes","no","activating","Bdnf","P23363","UNIPROT","Jak2","Q62689","UNIPROT","Rattus norvegicus","glial cell","BTO:0002606","","we employed Western blotting that enabled the visualization of phosphorylation events caused by BDNF and incurred upon JAK and STAT proteins","",""
+"Neurotrophin signaling pathway","Wnt signaling pathway","Neurotrophin AND Wnt","15207235","yes","no","activating","Ngf","P01139","UNIPROT","Gsk3b","Q9WV60","UNIPROT","Mus musculus","neuron","BTO:0000938","","Here we demonstrate that a tightly regulated and localized activation of phosphatidylinositol 3-kinase (PI3K) at the growth cone is essential for rapid axon growth induced by NGF.","",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","Neurotrophin AND Toll-like Receptor","20864924","unclear","","activating","NEU1","Q99519","UNIPROT","TLR4","O00206","UNIPROT","Homo sapiens","fibroblast","BTO:0000452","","Activated Neu1 sialidase hydrolyzes sialyl a-2,3-linked B-galactosyl residues distant from ligand binding to remove steric hinderance to TLR-4 dimerization","Honestly, I have no idea what this paper is saying...",""
+"Neurotrophin signaling pathway","MAPK signaling pathway","Neurotrophin AND MAPK","23772401","yes","no","activating","Ngf","P25427","UNIPROT","Ntrk1","P35739","UNIPROT","Rattus norvegicus","neuron","BTO:0000938","","Exogenously-added secretory PLA2 (sPLA2) enhanced NGF-induced MAPK phosphorylation","",""
+"Neurotrophin signaling pathway","Notch signaling pathway","Neurotrophin AND Notch","22028443","yes","no","activating","Ntrk2","P15209","UNIPROT","Notch2","O35516","UNIPROT","Mus musculus","oocyte","BTO:0000964","","These results suggest that neurotrophins acting via TRKB receptors facilitate early follicle growth by supporting a JAGGED1-NOTCH2 oocyte-to-GC communication pathway","",""
+"Neurotrophin signaling pathway","TNF signaling pathway","Neurotrophin AND TNF","18094051","yes","yes","activating","NGF","P01138","UNIPROT","TNF","P01375","UNIPROT","Homo sapiens","neuroblastoma cell","BTO:0000931","","We find that NGF induces TNFa synthesis in both neuroblastoma cells and normal neural cells in vitro.","transcriptional",""
+"Neurotrophin signaling pathway","VEGF signaling pathway","Neurotrophin AND VEGF","22562556","yes","yes","activating","Kidins220","E9Q9B7","UNIPROT","Kdr","P35918","UNIPROT","Mus musculus","neuron","BTO:0000938","","Through its interaction with VEGFR, Kidins220/ARMS might have a role in vascular development, connecting neurotrophins with VEGF signalling.","",""
+"Neurotrophin signaling pathway","NF-kappa B signaling pathway","Neurotrophin AND NF kappa B","23260665","yes","no","unknown","Arhgef28:Ngfr","P97433:Q9Z0W1","UNIPROT","Nfkb1","P25799","UNIPROT","Mus musculus","neuron","BTO:0000938","","RIP2 recruitment and RhoGDI release were mechanistically linked, indicating that competition for DD binding underlies crosstalk between NF-kB and RhoA pathways in p75(NTR) signaling.","",""
+"HIF-1 signaling pathway","Adipocytokine signaling pathway","HIF-1 AND Adipocytokine","17895881","no","","unknown","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","Wnt signaling pathway","HIF1 AND Wnt AND crosstalk","21502812","yes","no","inhibiting","HIF1A","Q16665","UNIPROT","APC","P25054","UNIPROT","Homo sapiens","cancer","","","Our study demonstrated that HIF-1 represses the APC promoter directly","",""
+"HIF-1 signaling pathway","GnRH signaling pathway","HIF-1 AND (GnRH OR LHRH)","24035332","no","","unknown","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","Toll-like receptor signaling pathway","HIF-1 AND Toll-like receptor","24389343","yes","yes","activating","HIF1A","Q16665","UNIPROT","TLR4","O00206","UNIPROT","Homo sapiens","leukocyte","BTO:0000751","","we identified a novel HIF-1-dependent noncanonical TLR activation pathway in circulating leukocytes leading to enhanced IL-18R expression which correlated with the magnitude of the ischemic area","",""
+"HIF-1 signaling pathway","MAPK signaling pathway","HIF-1 AND MAPK","14978738","yes","yes","activating","","","","","","","","","","","supports other direction","This study (PMID:14978738) shows that hypoxia induces activation of EGFR.",""
+"HIF-1 signaling pathway","Notch signaling pathway","(HIF-1) AND MAPK AND crosstalk","25108166","yes","yes","inhibiting","HIF1A","Q16665","UNIPROT","NOTCH1","P46531","UNIPROT","Homo sapiens","neuroblastoma cell","BTO:0000931","","Notch inhibition resulted in HIF-1a/Foxo3a signaling pathway up-regulation, suggesting the bidirectional crosstalk between HIF-1a and Notch1","",""
+"HIF-1 signaling pathway","TNF signaling pathway","HIF-1 AND TNF","22831955","unclear","no","activating","HIF1A","Q16665","UNIPROT","TNF","P01375","UNIPROT","Homo sapiens","hepatoma cell","BTO:0000608","","inhibition of both HIF-1a expression and reactive oxygen species generation significantly decreased TNFa-induced FoxM1 overexpression","HIF1A helps TNFa induce FoxM1 overexpression. Both proteins bind to promoter.",""
+"HIF-1 signaling pathway","VEGF signaling pathway","HIF-1 AND VEGF","22903062","yes","yes","activating","","","","","","","","","","","estradiolF7/8 form a transcriptional complex with HIF1 to stimulate VEGFA promoter activity","E2F7/8:HIF-1A/B",""
+"HIF-1 signaling pathway","TGF-beta signaling pathway","(HIF-1) AND TGF-B","25267627","yes","unknown","activating","HIF1A","Q16665","UNIPROT","TGFB1","P01137","UNIPROT","Homo sapiens","myofibroblast","BTO:0001946","","Hypoxia activates hypoxia-inducible factor 1(HIF-1) and induces autocrine TGF-B signaling that promotes myofibroblast activation and CXCL13 induction.","",""
+"Jak-STAT signaling pathway","Adipocytokine signaling pathway","Jak/STAT AND Adipocytokine","21841463","unclear","","activating","Jak2","Q62689","UNIPROT","Nampt","Q80Z29","UNIPROT","Rattus norvegicus","cardiac muscle fiber","BTO:0002320","","Visfatin expression was increased mainly through the AT1-R-JAK/STAT pathway in the process of Ang II-induced cardiomyocyte hypertrophy.","",""
+"Jak-STAT signaling pathway","Neurotrophin signaling pathway","Jak/STAT AND Neurotrophin AND cross-talk","22525700","no","","unknown","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","HIF-1 signaling pathway","(Jak-STAT OR Jak/STAT) AND HIF-1","24786382","no","","unknown","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","Wnt signaling pathway","Jak/STAT AND Wnt AND crosstalk","23172913","no","","unknown","","","","","","","","","","","","",""
+"Wnt signaling pathway","Jak-STAT signaling pathway","Jak/STAT AND Wnt AND crosstalk","23172913","no","","activating","","","","","","","","","","","Overexpression of EGF-like ligands leads to upregulation of upd1-3 and subsequent Jak/Stat pathway activation.","EGFR -> Jak/Stat","Overexpression of EGF-like ligands leads to upregulation of upd1-3 and subsequent Jak/Stat pathway activation."
+"Jak-STAT signaling pathway","GnRH signaling pathway","(Jak-STAT OR Jak/STAT) AND (GnRH OR LHRH)","21209203","yes","yes","activating","Jak2","Q62120","UNIPROT","[GNRH1/GNRH2]","[P01148/O43555]","UNIPROT","Mus musculus","neuron","BTO:0000938","","These results demonstrate an essential role for Jak2 signaling in GnRH neurons for normal reproductive development and fertility in female mice.","Transcriptional relationship: ""GnRH mRNA levels were reduced in Jak2 G(-/-) mice when compared with controls, while the number of GnRH neurons was equivalent, indicating a reduction in GnRH gene expression.""",""
+"Jak-STAT signaling pathway","ErbB signaling pathway","(Jak-STAT OR Jak/STAT) AND (ErbB OR EGFR) AND (crosstalk OR cross-talk)","19088723","no","","unknown","","","","","","","","","","","other direction","",""
+"Jak-STAT signaling pathway","Hippo signaling pathway","(Jak-STAT OR Jak/STAT) AND (Hippo)","22492181","no","","unknown","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","Toll-like receptor signaling pathway","Jak/STAT AND Toll-Like Receptor","17502339","yes","no","inhibiting","IFNG","P01579","UNIPROT","TLR2","O60603","UNIPROT","Homo sapiens","macrophage","BTO:0000801","","IFN-y suppresses TLR2 and TLR4 induction/activation of AP-1","",""
+"Jak-STAT signaling pathway","Toll-like receptor signaling pathway","Jak/STAT AND Toll-Like Receptor","25027037","yes","no","activating","Stat1","P42225","UNIPROT","Traf6","P70196","UNIPROT","Mus musculus","macrophage","BTO:0000801","","These results clearly demonstrate cross-talk between the TLR and JAK/STAT signaling pathways with direct recruitment of STAT1 by TRAF6 and that the direct activation of STAT1 by TLR signaling suggests a crucial role for STAT1 in TLR-induced inflammation.","",""
+"Jak-STAT signaling pathway","MAPK signaling pathway","Jak/STAT AND MAPK","24069558","yes","no","inhibiting","PIK3CA","P42336","UNIPROT","JAK2","O60674","UNIPROT","Homo sapiens","erythroleukemia cell","BTO:0000426","","we demonstrate that PI3K signaling regulates MAPK activation in JAK2-V617F-positve cells.","",""
+"Jak-STAT signaling pathway","Prolactin signaling pathway","(Jak-STAT OR Jak/STAT) AND (prolactin) AND (crosstalk OR cross-talk)","20826756","no","","unknown","","","","","","","","","","","other direction","",""
+"Jak-STAT signaling pathway","Insulin signaling pathway","(Jak-STAT OR Jak/STAT) AND (insulin) AND (crosstalk OR cross-talk)","19319849","no","","unknown","","","","","","","","","","","other direction","",""
+"Jak-STAT signaling pathway","VEGF signaling pathway","(Jak-STAT OR Jak/STAT) AND (vegf) AND (crosstalk OR cross-talk)","20652971","no","","unknown","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Jak-STAT signaling pathway","(Jak-STAT OR Jak/STAT) AND (TGFB) AND (crosstalk OR cross-talk)","18024957","","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Jak-STAT signaling pathway","(Jak-STAT OR Jak/STAT) AND Estrogen","23434684","yes","no","activating","CARM1","Q86X55","UNIPROT","JAK2","O60674","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","","Jak2, a member of the Jak/Stat signaling cascade, is one of the direct estradiol-dependent targets of the p/CIP/CARM1 complex","",""
+"Jak-STAT signaling pathway","NF-kappa B signaling pathway","(Jak-STAT OR Jak/STAT) AND (NF-kB)","17510282","yes","yes","inhibiting","STAT3","P40763","UNIPROT","RELA","Q04206","UNIPROT","Homo sapiens","HME cell","BTO:0002769","","P-STAT3 and P-p65 form a complex following stimulation of cells with both IL-1 and IL-6, after which STAT3 interacts with nonconsensus sequences at the 3’ boundary of kB element of the SAA promoter to enhance transcription","",""
+"Wnt signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND Wnt","23639831","unclear","","inhibiting","","","","","","","Mus musculus","cerebral cortical neuron","BTO:0004102","","each of the four Wnt inhibitors blocked the increase in protrusion density caused by BDNF overexpression","This paper discusses how BDNF induces the expression of several Wnts, thereby influencing dendric spine formation",""
+"Wnt signaling pathway","HIF-1 signaling pathway","(hif-1a) AND Wnt AND crosstalk","21502812","no","","inhibiting","APC","P25054","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","cancer","","","","Duplicate entry; please delete.",""
+"Wnt signaling pathway","GnRH signaling pathway","wnt AND gnrh","18218726","yes","yes","activating","[Tcf7/Tcf7l1/Tcf7l2]","[Q00417/Q9Z1J1/Q924A0]","UNIPROT","Jun","P05627","UNIPROT","Mus musculus","gonadotrophic cell","BTO:0002482","","Emerging new findings now indicate that B-catenin, a transcriptional coactivator and member of the canonical WNT signaling pathway, also plays an essential role in transducing the GnRH signal by interacting with multiple DNA-binding proteins in gonadotropes.","",""
+"Wnt signaling pathway","ErbB signaling pathway","Wnt AND ErbB AND (crosstalk OR cross-talk)","22274864","yes","yes","inhibiting","WNT3A","P56704","UNIPROT","ERBB3","P21860","UNIPROT","Homo sapiens","mesenchymal cell","BTO:0002625","","Downregulation of ErbB3 by Wnt3a contributes to wnt-induced osteoblast differentiation in mesenchymal cells","",""
+"Wnt signaling pathway","Hippo signaling pathway","Wnt AND Hippo","23245942","yes","yes","activating","WNT3A","P56704","UNIPROT","TAZ","Q16635","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","","Here, we report that TAZ, a biologically potent transcriptional coactivator, serves as a downstream element of the Wnt/b-catenin cascade","",""
+"Wnt signaling pathway","MAPK signaling pathway","wnt AND (mapk) AND Prolactin","22494971","yes","no","inhibiting","Gsk3b","Q9WV60","UNIPROT","Hras","Q61411","UNIPROT","Mus musculus","colonic cancer cell","BTO:0000586","","Our results indicated that GSK3B plays an essential role in Ras degradation","",""
+"MAPK signaling pathway","Wnt signaling pathway","wnt AND (mapk) AND Prolactin","23921141","yes","no","activating","Prl","P06879","UNIPROT","Lhcgr","P30730","UNIPROT","Mus musculus","ovary","BTO:0000975","","PRL thus appears to be a major permissive regulator of LH action in the ovary and of its secondary extragonadal effects.","",""
+"Wnt signaling pathway","Notch signaling pathway","wnt AND (notch) AND (crosstalk or cross-talk)","23132247","yes","no","inhibiting","dvl2","P51142","UNIPROT","csl","Other","Other","Xenopus laevis","epidermis","BTO:0000404","","we identify a dual function for Dishevelled as an inhibitor of Notch signalling and an activator of the Wnt pathway that sharpens the distinction between opposing Wnt and Notch responses","",""
+"Wnt signaling pathway","Insulin signaling pathway","wnt AND (insulin) AND (crosstalk or cross-talk)","23776620","yes","unknown","activating","GSK3B","P49841","UNIPROT","","","","Homo sapiens","B-lymphocyte","BTO:0000776","","Direct inhibition of GSK-3, that engages Wnt signaling downstream of the Wnt receptor, increases B-catenin nuclear translocation and B-cell proliferation but results in lower insulin content.","",""
+"Wnt signaling pathway","TNF signaling pathway","wnt AND (TNF) AND (crosstalk or cross-talk)","24286133","yes","yes","activating","Gsk3b","P18266","UNIPROT","Tnf","P16599","UNIPROT","Rattus norvegicus","nucleus pulposus","BTO:0003626","","The results of the present study provide in vitro evidence that activation of Wnt signaling upregulates the TNFa expression and might cause the degeneration of nucleus pulposus cells.","Transcriptional event",""
+"Wnt signaling pathway","TGF-beta signaling pathway","wnt AND (tgf-B) AND (crosstalk OR ""cross-talk"")","18045539","yes","no","activating","gsk3b","Q91757","UNIPROT","smad1","Q6PF32","UNIPROT","Xenopus laevis","embryo","BTO:0000379","","experiments in cultured mammalian cells and in Xenopus embryos indicated that Smad1 phosphorylation by GSK3 serves to integrate the BMP and Wnt signaling pathways","",""
+"Wnt signaling pathway","Estrogen signaling pathway","wnt AND (estrogen) AND (crosstalk OR ""cross-talk"")","15304487","yes","no","activating","arm","P18824","UNIPROT","ESR1","P03372","UNIPROT","Drosophila melanogaster","eye","BTO:0000439","","Thus, we present here the first direct evidence of cross-talk between Wnt and estrogen signaling pathways via functional interaction between B-catenin and ERa.","",""
+"Wnt signaling pathway","NF-kappa B signaling pathway","wnt AND (""NF kappa B"") AND (crosstalk OR ""cross-talk"")","22160170","yes","unknown","activating","","","","","","","Mesocricetus auratus","buccal mucosa cancer cell","BTO:0005769","","Our findings suggest a functional crosstalk between Wnt and NF-kB signaling pathways in HBP carcinomas","",""
+"GnRH signaling pathway","Neurotrophin signaling pathway","(gnRH OR LHRH) AND neurotrophin","15948150","unclear","","unknown","","","","","","","Homo sapiens","prostate gland cancer cell","BTO:0001130","","GnRH analogs","",""
+"GnRH signaling pathway","ErbB signaling pathway","(gnRH OR LHRH) AND ErbB","12963732","yes","no","activating","GNRHR","P30968","UNIPROT","MAPK3/MAPK1","P27361/P28482","UNIPROT","Homo sapiens","gonadotrophic cell","BTO:0002482","","Rapid engagement of the extracellular signal-regulated kinase (ERK) cascade via the Gq/11-coupled GnRH receptor (GnRHR) is mediated by transactivation of the epidermal growth factor receptor (EGFR).","",""
+"GnRH signaling pathway","MAPK signaling pathway","(gnRH OR LHRH) AND (MAPK) AND (crosstalk OR cross-talk)","20392830","yes","yes","activating","","","","","","","","alphaT3-1 cell","BTO:0003566","","GnRH stimulates COX-1 and COX-2 expression via the protein kinase C (PKC)/c-Src/phosphatidylinositol 3-kinase (PI3K)/MAPK pathway.","",""
+"GnRH signaling pathway","Notch signaling pathway","Notch AND (GnRH OR LHRH)","25332287","unclear","","activating","","","","","","","","","","","SSA induced by luteinizing hormone-releasinghormone (LHRH) receptor antagonism bypassed the surge in sex steroids caused by LHRH agonists, the gold standard for clinical ablation of sex steroids, thereby facilitating increased Dll4 expression and more rapid promotion of thymopoiesis.","",""
+"GnRH signaling pathway","Insulin signaling pathway","(gnRH OR LHRH) AND (insulin) AND (crosstalk OR cross-talk)","21317933","yes","no","activating","Cdh3","P10287","UNIPROT","Igf1r","Q60751","UNIPROT","Mus musculus","ovary cancer cell","BTO:0001023","","GnRH can initiate an outside-in p120ctn signal transduction through the cross-talk between P-cadherin and IGF-1R","",""
+"GnRH signaling pathway","VEGF signaling pathway","(gnRH OR LHRH) AND VEGF","24228111","yes","yes","inhibiting","GNRH2","O43555","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","endometrial stromal cell","BTO:0003697","","GnRH-II significantly inhibited the cell proliferation, induced cell apoptosis and decreased the VEGF secreting of ectopic, eutopic and normal ESC in EMs in vitro, and these effects were the strongest on ectopic ESC, which suggested that GnRH-II may become a new effective treatment for endometriosis.","",""
+"GnRH signaling pathway","VEGF signaling pathway","(gnRH OR LHRH) AND VEGF","23764202","","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","Estrogen signaling pathway","(gnRH OR LHRH) AND (estrogen) AND Demay","11459776","yes","yes","activating","Gnrh1","P07490","UNIPROT","Esr1","P06211","UNIPROT","Rattus norvegicus","alphaT3-1 cell","BTO:0003566","","our data demonstrate that GnRH is an important signal in the regulation of ERalpha trans-activation in gonadotrope cells","",""
+"GnRH signaling pathway","Estrogen signaling pathway","(gnRH OR LHRH) AND (estrogen) AND (crosstalk OR cross-talk)","8818404","unclear","","activating","","","","","","","Rattus norvegicus","gonadotrophic cell","BTO:0002482","","a cross-talk between the GnRH and nuclear ER may occur in the gonadotrope cells","",""
+"GnRH signaling pathway","NF-kappa B signaling pathway","(gnRH OR LHRH) AND (NF-kB)","11061544","yes","no","activating","GNRH1","P01148","UNIPROT","NFKB1","P19838","UNIPROT","Homo sapiens","ovary cancer cell","BTO:0001023","","We conclude that LHRHinduces activation of NFkappaB and thus reduces Doxorubicin-induced apoptosis in human ovarian cancer cells.","",""
+"ErbB signaling pathway","Wnt signaling pathway","ErbB AND Wnt","22457761","yes","unknown","activating","Erbb2","P70424","UNIPROT","Ctnnb1","Q02248","UNIPROT","Mus musculus","breast cancer cell","BTO:0000150","","Our study thus provides provocative evidence for Wnt/B-catenin signaling as an early, HER2/neu-inducible event in breast neoplasia.","",""
+"ErbB signaling pathway","Wnt signaling pathway","ErbB AND Wnt","22457761","yes","unknown","activating","Erbb2","P70424","UNIPROT","Ctnnb1","Q02248","UNIPROT","Mus musculus","mammary gland tumor cell","BTO:0004087","","Our study thus provides provocative evidence for Wnt/B-catenin signaling as an early, HER2/neu-inducible event in breast neoplasia.","",""
+"ErbB signaling pathway","Hippo signaling pathway","(erbb OR egfr) AND (hippo)","15618521","yes","no","inhibiting","RAF1","P04049","UNIPROT","STK3","Q13188","UNIPROT","Homo sapiens","fibroblast","BTO:0000452","","Raf-1 prevents dimerization and phosphorylation of the activation loop of MST2 independently of its protein kinase activity.","",""
+"ErbB signaling pathway","Toll-like receptor signaling pathway","(erbb OR egfr) AND (""toll-like receptor"" OR TLR) AND (crosstalk OR cross-talk)","23994140","no","","activating","EGFR","P00533","UNIPROT","MAPK3/MAPK1","P27361/P28482","UNIPROT","Homo sapiens","skin","BTO:0001253","","EGFR can be linked to CD14-TLR and TNF through the MAPK crosstalk points","Not an experiment; model",""
+"ErbB signaling pathway","MAPK signaling pathway","(erbb OR egfr) AND (MAPK) AND (crosstalk OR cross-talk)","23794705","yes","no","activating","Egfr","Q01279","UNIPROT","Met","P16056","UNIPROT","Mus musculus","marrow cell","BTO:0001441","","EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis","",""
+"ErbB signaling pathway","Prolactin signaling pathway","Prolactin AND (ErbB OR EGFR)","21914800","yes","yes","activating","Egfr","Q01279","UNIPROT","Prl","P06879","UNIPROT","Mus musculus","mammary gland","BTO:0000817","","These results provide the first functional evidence in vivo for a role of the EGFR system in regulating mammary gland activity by modulating prolactin release from the pituitary gland.","Transcriptional relationship",""
+"Notch signaling pathway","ErbB signaling pathway","(erbb OR egfr) AND (notch) AND (crosstalk OR cross-talk)","19176515","unclear","yes","unknown","N","P07207","UNIPROT","Egfr","P04412","UNIPROT","Drosophila melanogaster","wing disc","BTO:0001464",""," ","high-confidence targets of notch; explicit mechanisms not listed","Through combining these data, we identify high-confidence direct targets of Notch that are implicated in the maintenance of adult muscle progenitors in vivo."
+"ErbB signaling pathway","Insulin signaling pathway","","19034632","yes","no","inhibiting","","","","","","","","","","","supports other direction","suppression of IGF-IR signaling by EGFR has been demonstrated through effective interaction with the adaptor protein IRS-1 by EGFR.",""
+"ErbB signaling pathway","TNF signaling pathway","(erbb OR egfr) AND (""tumor necrosis factor"" OR TNF) AND (crosstalk OR cross-talk)","19692652","yes","no","activating","[MAP2K1/MAP2K2/MAP2K7/MAP2K6/MAP2K3/MAP2K4/MAP2K5],[MAPK11/MAPK12/MAPK13/MAPK14],[PIK3CA/PIK3CB/PIK3CG/PIK3CD/PIK3R1/PIK3R2/PIK3R3/PIK3R4/PIK3R5/PIK3R6/PIK3C2A/PIK3C2B/PIK3C2G/PIK3C3]","[Q02750/P36507/O14733/P52564/P46734/P45985/Q13163],[Q15759/P53778/O15264/Q16539],[P42336/P42338/P48736/O00329/P27986/O00459/Q92569/Q99570/Q8WYR1/Q5UE93/O00443/O00750/O75747/Q8NEB9]","UNIPROT","TNFRSF1A","P19438","UNIPROT","Homo sapiens","mesenchymal stem cell","BTO:0003298","","MEK, p38, and PI-3K mediate cross talk between EGFR and TNFR in enhancing hepatocyte growth factor production from human mesenchymal stem cells","",""
+"ErbB signaling pathway","TNF signaling pathway","(erbb OR egfr) AND (""tumor necrosis factor"" OR TNF) AND (crosstalk OR cross-talk)","24453000","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","VEGF signaling pathway","ErbB VEGF cross-talk","21439312","unclear","yes","unknown","","","","","","","","","","","","",""
+"ErbB signaling pathway","TGF-beta signaling pathway","(erbb OR egfr) AND (MAPK) AND (crosstalk OR cross-talk)","24973511","yes","no","activating","EGF","P01133","UNIPROT","TGFB1","P01137","UNIPROT","Homo sapiens","thyroid cancer cell","BTO:0000196","","reinforced the hypothesis of a cross-talk between EGF and TGF-B1 systems in follicular thyroid carcinomas phenotype","",""
+"ErbB signaling pathway","Estrogen signaling pathway","(erbb OR egfr) AND (estrogen) AND (crosstalk OR cross-talk)","25275589","yes","no","inhibiting","EGFR","P00533","UNIPROT","GPER1","Q99527","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","","we found that upregulation of p21 by the cross-talk of GPR30/EGFR and p53 was also involved in G-1-induced cell growth arrest.","",""
+"ErbB signaling pathway","NF-kappa B signaling pathway","(erbb OR egfr) AND (NF-kB) AND (crosstalk OR cross-talk)","19946332","yes","no","activating","ERBB2","P04626","UNIPROT","NFKB1","P19838","UNIPROT","Homo sapiens","epithelial cell","BTO:0000414","","Our study suggests different roles for the NF-kappaB and PI3K pathways downstream of Her2","",""
+"Hippo signaling pathway","Neurotrophin signaling pathway","hippo AND neurotrophin","23516327","no","","unknown","","","","","","","","","","","","",""
+"Hippo signaling pathway","HIF-1 signaling pathway","HIF-1 AND Hippo","23566416","unclear","","activating","TAZ","Q16635","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","","Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ)","Hard to say. Both Sarah and I cite the same paper. On one side, TAZ binds to HIF1 to induce HIF1 transcriptional events. However, the condition for this appears to be hypoxic.",""
+"Hippo signaling pathway","Jak-STAT signaling pathway","hippo AND (jak-STAT OR jak/STAT) AND (crosstalk OR cross-talk)","22492181","yes","no","inhibiting","yki","Q45VV3","UNIPROT","","","","Drosophila melanogaster","","","","suggesting that loss of Hippo signaling or excessive Yki activity might result in elevated Jak/Stat","Jak1 as protein B?",""
+"Hippo signaling pathway","Wnt signaling pathway","hippo AND Wnt","20412773","yes","no","activating","Wwtr1","Q9EPK5","UNIPROT","Wnt3a","P27467","UNIPROT","Mus musculus","kidney","BTO:0000671","","Quantitative real-time PCR analysis revealed that knockdown of TAZ in MDA-MB-231 cells enhanced Wnt3A-induced AXIN2, NKD1, and TNFRSF19 expression","",""
+"ErbB signaling pathway","Hippo signaling pathway","hippo AND (ErbB OR EGFR)","20713513","yes","no","activating","RAF1","Other","Other","STK4","A4K2Y1","UNIPROT","Cercopithecus aethiops","COS-1 cell","","","In particular, Raf-1 has been shown to bind directly to Mst2 and prevent Mst2 from associating with RASSF1A, which, upon forming a complex with Mst2, stimulates its kinase activity and enhances its interaction with Lats1 (O'Neill et al. 2004; Matallanas et al. 2007).","cites: 15618521",""
+"Hippo signaling pathway","Toll-like receptor signaling pathway","hippo AND (TLR OR Toll-like receptor)","22443485","no","","unknown","","","","","","","","","","","","",""
+"Hippo signaling pathway","MAPK signaling pathway","hippo AND (MAPK)","24803537","yes","no","inhibiting","Yap1","P46938","UNIPROT","Kras","P32883","UNIPROT","Mus musculus","pancreas","BTO:0000988","","Together, our findings identified Yap as a critical oncogenic KRAS effector","Appears to crosstalk. Published the day I finished curating the gold-standard.",""
+"Hippo signaling pathway","Notch signaling pathway","hippo AND notch AND (crosstalk OR cross-talk)","22492181","yes","no","inhibiting","","","","","","","","","","","activation of the Notch signaling pathway results from the inacti- vation of Hippo signaling","",""
+"Hippo signaling pathway","TNF signaling pathway","hippo AND TNF","20890045","yes","no","inhibiting","Rassf1","Q99MK9","UNIPROT","Tnf","P06804","UNIPROT","Mus musculus","cardiofibroblast","BTO:0003093","","In cardiac fibroblasts, the Rassf1A/Mst1 pathway negatively regulated TNFa","",""
+"Hippo signaling pathway","TGF-beta signaling pathway","hippo AND (TGF-B) AND (crosstalk OR cross-talk)","12118366","yes","no","activating","YAP1","P46937","UNIPROT","SMAD7","O15105","UNIPROT","Cercopithecus aethiops","COS-7 cell","BTO:0000298","","We have identified YAP65 as a novel Smad7-interacting protein involved in the association of Smad7 to activated TRI.","",""
+"Hippo signaling pathway","Estrogen signaling pathway","hippo AND (Estrogen) AND (crosstalk OR cross-talk)","16772533","yes","no","inhibiting","YAP1","P46937","UNIPROT","WBP2","Q969T9","UNIPROT","Homo sapiens","HeLa cell","BTO:0000567","","Taken together, our data establish the role of WBP-2 and YAP as coactivators for ER and PR transactivation pathways.","",""
+"Hippo signaling pathway","NF-kappa B signaling pathway","(hippo) AND (NF-kB)","22227519","yes","no","inhibiting","Rassf2","Q8BMS9","UNIPROT","Nfkb1","P25799","UNIPROT","Mus musculus","osteoblast","BTO:0001593","","Introduction of either RASSF2 or a dominant-negative form of IKK into Rassf2 osteoclast or osteoblast precursors inhibited NF-kB hyperactivation and normalized osteoclast and osteoblast differentiation.","",""
+"Adipocytokine signaling pathway","Toll-like receptor signaling pathway","((Toll-like Receptor) OR TLR) AND (Adipocytokine)","23674516","yes","yes","inhibiting","Adipoq","Q60994","UNIPROT","Tlr4","Q9QUK6","UNIPROT","Mus musculus","cardiac muscle fiber","BTO:0002320","","APN inhibited the expression of a TLR4-mediated inflammatory phenotype induced by exogenous and endogenous TLR4 ligands","",""
+"Neurotrophin signaling pathway","Toll-like receptor signaling pathway","((Toll-like Receptor) OR TLR) AND (Neurotrophin)","24662564","unclear","no","","spz3","Q9VLV7","UNIPROT","Tollo","Q9V477","UNIPROT","Drosophila melanogaster","larva","BTO:0000707","","These results demonstrate the existence of a novel neurotrophin signaling pathway that is required for synaptic development in Drosophila. ","",""
+"Toll-like receptor signaling pathway","HIF-1 signaling pathway","((Toll-like Receptor) OR TLR) AND (HIF-1)","24978883","no","","unknown","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","Jak-STAT signaling pathway","((Toll-like Receptor) OR TLR) AND ((Jak/STAT) OR Jak-STAT) AND (crosstalk OR (cross-talk))","23612802","yes","no","activating","TLR4","O00206","UNIPROT","STAT3","P40763","UNIPROT","Homo sapiens","urinary bladder cancer cell","BTO:0000362","","Upon ligation to the ligand, TLR4 triggers serial signal transduc- tion pathways leading to the activation of MAPK and STAT3","",""
+"Toll-like receptor signaling pathway","Wnt signaling pathway","wnt AND (toll-like receptor OR TLR) AND (crosstalk or cross-talk)","18456733","yes","no","activating","Tlr4","Q9QUK6","UNIPROT","Wnt5a","P22725","UNIPROT","Mus musculus","heart","BTO:0000562","","Thus there is a growing body of evidence that suggests an interaction between TLR-4 and Wnt5a, specifically that activation of the TLR-4 signal cascade leads to expression of Wnt5a.","",""
+"Toll-like receptor signaling pathway","GnRH signaling pathway","((Toll-like Receptor) OR TLR) AND (GnRH OR LHRH)","25016551","unclear","","unknown","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","ErbB signaling pathway","(""Toll-like Receptor"" OR TLR) AND (ErbB OR EGFR)","24513215","unclear","","activating","","","","","","","","respiratory epithelium cell","BTO:0004533","","Together, our finding shows that in addition to the TLR-mediated TPL2 activation of ERK1/ERK2","This paper more shows a relationship between TLR- and EGFR- with ERK. Does not discuss the downstream targets of ErbB (Jun, Fos)",""
+"Toll-like receptor signaling pathway","MAPK signaling pathway","(""Toll-like Receptor"" OR TLR) AND (MAPK) AND (crosstalk OR ""cross-talk"")","23979601","yes","no","activating","Tlr1","Q9EPQ1","UNIPROT","Akt1","P31750","UNIPROT","Mus musculus","macrophage","BTO:0000801","","These data describe a novel role for p38a-MK2/3 in regulating TLR-induced Akt activation in macrophages.","BMDM",""
+"Toll-like receptor signaling pathway","Prolactin signaling pathway","(""Toll-like Receptor"" OR TLR) AND (Prolactin) AND (crosstalk OR ""cross-talk"")","20826756","no","","unknown","","","","","","","Sparus aurata","macrophage","BTO:0000801","","Taken together, the above results demonstrate that PRL is able to modulate IL-1B expression in seabream macrophages and strongly suggest the existence of cross-talk between the PRLR and TLR signaling pathways.","This paper suggests the other direction, and that PRL stimulates the expresion of IL1b.",""
+"Toll-like receptor signaling pathway","Notch signaling pathway","(""Toll-like Receptor"" OR TLR) AND (Notch) AND (crosstalk OR ""cross-talk"")","20870935","yes","no","activating","Tlr1","Q9EPQ1","UNIPROT","Jag1","Q9QXX0","UNIPROT","Mus musculus","macrophage","BTO:0000801","","TLRs induced Jagged1 expression rapidly and independently of new protein synthesis.","BMDM",""
+"Notch signaling pathway","Toll-like receptor signaling pathway","(""Toll-like Receptor"" OR TLR) AND (Notch) AND (crosstalk OR ""cross-talk"")","24048326","yes","no","activating","Notch1","Q01705","UNIPROT","Tlr5","Q9JLF7","UNIPROT","Mus musculus","colon","BTO:0000269","","Conversely, using a y-secretase inhibitor, we demonstrated that Notch synergistically increases TLR5-mediated NF-kB activation.","",""
+"Toll-like receptor signaling pathway","Insulin signaling pathway","(""Toll-like Receptor"" OR TLR) AND (Insulin) AND (crosstalk OR ""cross-talk"")","22961082","yes","no","inhibiting","TLR4","O00206","UNIPROT","RETN","Q9HD89","UNIPROT","Homo sapiens","neuroblastoma cell","BTO:0000931","","Taken together, our findings clearly identify TLR4 as the binding site for resistin in the hypothalamus and bring new insight into the molecular mechanisms involved in resistin-induced inflammation and insulin resistance in the whole animal.","As expected, the overexposure of wild-type SH-SY5Y cells to resistin markedly attenuated the phosphorylations of AKT and ERK1/2 in response to insulin. Interestingly, TLR4 knockdown restores the insulin-dependent phosphorylation of both AKT and ERK1/2 in resistin-treated cells",""
+"Toll-like receptor signaling pathway","TNF signaling pathway","(""Toll-like Receptor"" OR TLR) AND (TNF) AND (crosstalk OR ""cross-talk"")","24758719","yes","no","activating","Tlr2","Q9QUN7","UNIPROT","Traf6","P70196","UNIPROT","Mus musculus","macrophage","BTO:0000801","","In summary, our results reveal a novel route of TLR signal that synergistically amplifies TNF-mediated responses, indicating an innovative target for inflammation manipulation.","BMDM",""
+"Toll-like receptor signaling pathway","NF-kappa B signaling pathway","(""Toll-like Receptor"" OR TLR) AND (NF-kB) AND (crosstalk OR cross-talk)","10094049","yes","no","activating","MAP3K7","O43318","UNIPROT","TRAF6","Q9Y4K3","UNIPROT","Homo sapiens","293-IL-1RI cell","BTO:0003465","","Our results indicate that TAK1 links TRAF6 to the NIK-IKK cascade in the IL-1 signalling pathway.","",""
+"Adipocytokine signaling pathway","MAPK signaling pathway","MAPK AND Adipocytokine AND (crosstalk OR ""cross-talk)","24604418","yes","no","activating","Rbp4","P04916","UNIPROT","Map2k1","Q01986","UNIPROT","Rattus norvegicus","aortic smooth muscle cell","BTO:0004577","","These results suggest that RBP4 mediates VSMC proliferation induced by insulin via activation of the MAPK pathway, and highlight RBP4 as a modulator of atherosclerosis in hyperinsulinemia, therby enhancing our understanding on a number of unexpected aspects of CVD.","",""
+"MAPK signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND MAPK","18974393","yes","no","activating","[MAPK11/MAPK14/MAPK12]","[Q15759/Q16539/P53778]","UNIPROT","NGFR","P08138","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","","Expression of a dominant negative form of MK2, the kinase downstream of p38 MAPK frequently associated with signaling cascades leading to apoptosis, prevented carprofen induction of the p75NTR protein.","",""
+"MAPK signaling pathway","Jak-STAT signaling pathway","Jak-STAT AND Wnt AND crosstalk","23172913","yes","no","activating","Egfr","P04412","UNIPROT","upd1,upd2,upd3","O96525,Q9VWX2,Q59E38","UNIPROT","Drosophila melanogaster","midgut","BTO:0000863","","Overexpression of EGF-like ligands leads to upregulation of upd1-3 and subsequent Jak/Stat pathway activation.","",""
+"MAPK signaling pathway","Jak-STAT signaling pathway","Jak/STAT AND MAPK AND crosstalk","20200229","yes","no","inhibiting","[MAPK11/MAPK14/MAPK12/MAPK13]","[Q15759/Q16539/P53778/O15264]","UNIPROT","IL6","P05231","UNIPROT","Homo sapiens","Hep-G2 cell","BTO:0000599","","We show that p38, activated by IL-1beta, TNFalpha or environmental stress, impairs IL-6-induced JAK/STAT signalling","This seems valid.",""
+"MAPK signaling pathway","Hippo signaling pathway","MAPK AND Hippo AND (crosstalk OR ""cross-talk"")","23484853","yes","no","activating","Ras85D","P08646","UNIPROT","yki","Q45VV3","UNIPROT","Drosophila melanogaster","S2 cell","BTO:0003070","","activation of EGFR or RAS activates the Yorkie homolog YAP","",""
+"MAPK signaling pathway","Notch signaling pathway","MAPK AND notch AND (crosstalk OR ""cross-talk"")","16023595","yes","no","activating","MAPK","Other","Other","JAG1","P78504","UNIPROT","Homo sapiens","squamous cell carcinoma cell","BTO:0001289","Cancer cells","Here, we report that the Notch ligand Jagged1 induced by growth factors via mitogen-activating protein kinase (MAPK) in head and neck squamous cell carcinoma (HNSCC) cells triggered Notch activation in neighboring endothelial cells (ECs) and promoted capillary-like sprout formation.","",""
+"MAPK signaling pathway","VEGF signaling pathway","HIF-1 AND VEGF AND crosstalk","24668751","no","","inhibiting","","","","","","","Mus musculus","endothelial cell","BTO:0001176","","Increases in VEGF and NADPH oxidase levels were abrogated by inhibitors of NADPH oxidase and MAPK, respectively, suggesting the possibility of crosstalk between pathways.","Transcriptional relationship",""
+"MAPK signaling pathway","TGF-beta signaling pathway","MAPK AND (TGF-B) AND (crosstalk OR cross-talk)","21333552","yes","no","inhibiting","Map3k2:Map3k3","Q61083:Q61084","UNIPROT","Tgfb1","P04202","UNIPROT","Mus musculus","helper T-lymphocyte","BTO:0002417","","Here we showed that the MAPK kinase kinases MEKK2 (encoded by Map3k2) and MEKK3 (encoded by Map3k3), negatively regulated transforming growth factor-B (TGF-B)-mediated Th cell differentiation.","",""
+"MAPK signaling pathway","Estrogen signaling pathway","MAPK AND Estrogen AND (crosstalk OR cross-talk)","21720253","yes","no","activating","","","","","","","","uterine endometrial cancer cell","BTO:0003871","","The MEK1/2 inhibitor, U0126, and the stress-activated protein kinase/c-Jun NH2-terminal kinase inhibitor, SP600125, significantly suppressed the proliferation of human endometrial cancer cell lines RL95-2 and KLE induced by estradiol (P < 0.05).","",""
+"MAPK signaling pathway","NF-kappa B signaling pathway","MAPK AND NF-kB AND (crosstalk OR cross-talk)","21465312","yes","no","activating","[MAPK11/MAPK14/MAPK12]","[Q15759/Q16539/P53778]","UNIPROT","NFKB1","P19838","UNIPROT","Homo sapiens","skin","BTO:0001253","","Thus, activation of p38 MAPK by Zn-Cu might be one of the mechanisms involved in suppression of NF-jB activity and downstream anti-inflammatory effects.","",""
+"MAPK signaling pathway","NF-kappa B signaling pathway","MAPK AND NF-kB AND (crosstalk OR cross-talk)","19931510","yes","no","activating","Mapk14","P47811","UNIPROT","Rela","Q04207","UNIPROT","Mus musculus","C2C12 cell","BTO:0000165","C2C12 cell line","These results provides the first evidence of a cross-talk between p38 MAPK and NF-kappaB signaling pathways during stretch-induced myogenesis, with phosphorylation of RelA being one of the effectors of this promyogenic mechanism.","",""
+"Prolactin signaling pathway","Jak-STAT signaling pathway","Prolactin AND ""HIF-1"" AND (crosstalk OR ""cross-talk"")","21655368","yes","no","activating","PRLR","P16471","UNIPROT","STAT5A","P42229","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","","STAT5a, is activated in the breast upon prolactin toprolactin receptor (PRLR) binding facilitating the transcription of genes involved in lobule development.","",""
+"Prolactin signaling pathway","GnRH signaling pathway","Prolactin AND (GnRH OR LHRH)","23921141","yes","no","activating","Prl","P06879","UNIPROT","Lhcgr","P30730","UNIPROT","Mus musculus","ovary","BTO:0000975","","PRL thus appears to be a major permissive regulator of LH action in the ovary and of its secondary extragonadal effects.","Seems good.",""
+"Prolactin signaling pathway","ErbB signaling pathway","Prolactin AND (ErbB OR EGFR)","10938266","yes","no","activating","PRL","P01236","UNIPROT","ERBB2","P04626","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","","Our results indicate that autocrine secretion of PRL stimulates tyrosine phosphorylation of ErbB-2 by Jak2, provides docking sites for Grb2 and stimulates Ras-MAP kinase cascade, thereby causing unrestricted cellular proliferation.","",""
+"Prolactin signaling pathway","MAPK signaling pathway","Prolactin AND MAPK","11043575","yes","no","activating","Prl","P01237","UNIPROT","[MAPK8/MAPK9]","[P45983/P45984]","UNIPROT","Rattus norvegicus","NB-2 cell","BTO:0003056","","Immunoblot analysis with an antibody that recognizes the activated (phosphorylated) forms of JNK1 and JNK2 indicated that both JNK1 and JNK2 isoforms were activated in 32D/hPRLR cells stimulated with oPRL.","",""
+"Prolactin signaling pathway","Notch signaling pathway","Prolactin AND Notch","10938266","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","Insulin signaling pathway","Prolactin AND Insulin","23775766","yes","no","unknown","Prlr","Q08501","UNIPROT","glucosamine","amino sugar","amino sugar","Mus musculus","","","","overexpression of PRLR in vitro increases insulin-stimulated phosphorylation of IR and Akt,","",""
+"Prolactin signaling pathway","TNF signaling pathway","Prolactin AND (""Jak/STAT"" OR ""Jak-STAT"")","18187558","yes","no","activating","Prl","P06879","UNIPROT","Tnf","P06804","UNIPROT","Mus musculus","macrophage","BTO:0000801","","Further, pre-treatment of macrophages with SP600125 inhibited the PRL-induced production of IFN-y and TNFa.","",""
+"Prolactin signaling pathway","VEGF signaling pathway","Prolactin AND VEGF","15352176","yes","yes","activating","PRL","P01236","UNIPROT","HMOX1","P09601","UNIPROT","Homo sapiens","endothelial cell","BTO:0001176","","PRL-treated macrophages also showed an enhanced release of vascular endothelial growth factor (VEGF) as demonstrated by ELISA assay.","HIF-1 TF, but enhances VEGF activity",""
+"Prolactin signaling pathway","VEGF signaling pathway","Prolactin AND VEGF","25472535","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","TGF-beta signaling pathway","Prolactin AND (TGF-B)","14963111","no","no","unknown","","","","","","","","","","","","",""
+"Prolactin signaling pathway","Estrogen signaling pathway","Prolactin AND Estrogen AND (crosstalk OR ""cross-talk"")","12670737","yes","no","activating","","","","","","","","","","","ERTranscription of the genes encoding both ERalpha (Esr1) and ERbeta (Esr2) is stimulated by PRL through the Jak2-Stat5 pathway and Stat5-response elements that are located in each of the Esr promoters.","this is the review; find primary",""
+"Prolactin signaling pathway","NF-kappa B signaling pathway","Prolactin AND NF-kB AND (crosstalk OR cross-talk)","20826756","yes","no","activating","prl","O93337","UNIPROT","IL-1b","Q90W32","UNIPROT","Sparus aurata","macrophage","BTO:0000801","","The results showed that PRL was able to induce the production of reactive oxygen species and the expression of IL-1B and TNFa in a similar way to two major pathogen-associated molecular patterns: polyinosinic-polycytidylic acid and genomic DNA from the bacterium Vibrio anguillarum.","",""
+"Notch signaling pathway","HIF-1 signaling pathway","Notch AND HIF-1 AND (crosstalk OR ""cross-talk"")","25108166","yes","no","inhibiting","HIF1A","Q16665","UNIPROT","NOTCH1","P46531","UNIPROT","Homo sapiens","brain","BTO:0000142","","Notch inhibition resulted in HIF-1a/Foxo3a signaling pathway up-regulation, suggesting the bidirectional crosstalk between HIF-1a and Notch1","",""
+"Notch signaling pathway","Jak-STAT signaling pathway","Notch AND (""Jak/STAT"" OR ""Jak-STAT"") AND (crosstalk OR ""cross-talk"")","15156153","yes","no","activating","","","","","","","","","","","These results suggest that direct protein-protein interactions coordinate cross-talk between the Notch-Hes and JAK-STAT pathways.","",""
+"Notch signaling pathway","Wnt signaling pathway","Notch AND Wnt","8596950","yes","no","inhibiting","dsh","P51140","UNIPROT","N","P07207","UNIPROT","Drosophila melanogaster","","","","It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways.","",""
+"Notch signaling pathway","ErbB signaling pathway","Notch AND (ErbB OR EGFR) AND (crosstalk OR ""cross-talk"")","19219656","yes","no","activating","NOTCH1","P46531","UNIPROT","EGFR","P00533","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","","Overexpression of Notch1 could reverseEGFR inhibitor-induced cell toxicity, suggesting that Notch and EGFR signaling may be positively cross-linked in human breast cancer.","",""
+"Notch signaling pathway","Hippo signaling pathway","Notch AND Hippo AND (crosstalk OR ""cross-talk"")","25157415","yes","no","inhibiting","N","P07207","UNIPROT","yki","Q45VV3","UNIPROT","Drosophila melanogaster","wing disc","BTO:0001464","","Notch pathway activation restricts the effects of Yki mediated transcription, therefore contributing to define a zone of low proliferation in the central wing discs.","",""
+"Notch signaling pathway","Toll-like receptor signaling pathway","Notch AND (""Toll-like Receptor"" OR TLR) AND (crosstalk OR ""cross-talk"")","24048326","yes","no","activating","Notch1","Q01705","UNIPROT","Tlr5","Q9JLF7","UNIPROT","Mus musculus","colon","BTO:0000269","","Conversely, using a y-secretase inhibitor, we demonstrated that Notch synergistically increases TLR5-mediated NF-kB activation.","",""
+"Notch signaling pathway","MAPK signaling pathway","Notch AND MAPK AND (crosstalk OR ""cross-talk"")","17158101","yes","no","inhibiting","Notch1","Q01705","UNIPROT","Dusp1","P28563","UNIPROT","Mus musculus","myoblast","BTO:0000222","","These results reveal a novel cross-talk between the Notch pathway and the p38 MAPK pathway that is mediated by Notch induction of MKP-1.","",""
+"Notch signaling pathway","Insulin signaling pathway","Notch AND Insulin","21804540","yes","no","activating","Notch1","Q01705","UNIPROT","Foxo1","Q9R1E0","UNIPROT","Mus musculus","hepatocyte","BTO:0000575","","The data identify a heretofore unknown metabolic function of Notch and suggest that Notch inhibition is beneficial in diabetes treatment, in part by helping to offset excessive FoxO1-driven hepatic glucose production.","",""
+"Notch signaling pathway","TNF signaling pathway","Notch AND TNF","22593207","yes","no","inhibiting","NUMBL","Q9Y6R0","UNIPROT","TRAF5","O00463","UNIPROT","Homo sapiens","glioma cell","BTO:0000526","","n conclusion, our data suggest that Numbl negative regulates glioma cell migration and invasion by abrogating TRAF5-induced activation of NF-kB.","",""
+"Notch signaling pathway","VEGF signaling pathway","Notch AND VEGF AND (crosstalk OR ""cross-talk"")","17692341","yes","no","activating","DLL4","Q9NR61","UNIPROT","FLT1","P17948","UNIPROT","Homo sapiens","HUVEC cell","BTO:0001949","","However extensive upregulation of VEGFR1 was observed allowing continued response to its ligand PlGF but the soluble form of the VEGFR1, sVEGFR1 was also upregulated.","",""
+"Notch signaling pathway","TGF-beta signaling pathway","Notch AND ""TGF-B"" AND (crosstalk OR ""cross-talk"")","14638857","yes","yes","activating","NOTCH-1","Q9W737","UNIPROT","SMAD3","P84023","UNIPROT","Gallus gallus","embryo","BTO:0000379","","In a reciprocal situation, our observations suggest a mechanism by which Notch signaling could influence the expression of TGF-B target genes.","not sure of tissue",""
+"Notch signaling pathway","TGF-beta signaling pathway","TGF-B AND Notch AND (crosstalk OR ""cross-talk"")","22585622","yes","yes","activating","HES1","Q14469","UNIPROT","TGFBR2","P37173","UNIPROT","Homo sapiens","T-lymphocyte","BTO:0000782","","We demonstrate that HES (hairy and enhancer of split), the main transcription factor downstream of Notch, induces strong transactivation of TGF-BRII by binding the TGF-BRII promoter through its DNA-binding domain.","Transcriptional relationship",""
+"Notch signaling pathway","Estrogen signaling pathway","Notch AND Estrogen AND (crosstalk OR ""cross-talk"")","19838210","yes","no","activating","","","","","","","","","","","Our data support a model in which Notch1 can activate the transcription of ERalpha-target genes via IKKalpha-dependent cooperative chromatin recruitment of Notch-CSL-MAML1 transcriptional complexes (NTC) and ERalpha, which promotes the recruitment of p300.","",""
+"Notch signaling pathway","NF-kappa B signaling pathway","(""Toll-like Receptor"" OR TLR) AND (notch) AND (crosstalk OR ""cross-talk"")","23203159","yes","no","activating","","","","","","","Mus musculus","colonic epithelium","BTO:0001709","","Thus functional cross talk between the Notch and NF-kB pathways during TMCH regulates hyperplasia and/or inflammation in response to CR infection.","",""
+"Insulin signaling pathway","Adipocytokine signaling pathway","Insulin AND Adipocytokine AND (crosstalk OR ""cross-talk"")","19047149","yes","no","activating","IGF1","P05019","UNIPROT","LEPR","P48357","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","","We found a novel bidirectional crosstalk between leptin and IGF-I signaling; IGF-I induced phosphorylation of leptin receptor (Ob-Rb) and leptin induced phosphorylation of IGF-I receptor (IGF-IR), whereas downstream effectors, Akt and extracellular signal-regulated kinase.synergistic phosphorylation and association of Ob-Rb and IGF-IR along with activation of cotreatment induced","",""
+"Insulin signaling pathway","Neurotrophin signaling pathway","Insulin AND Neurotrophin","25232115","yes","no","activating","IGF1R","P08069","UNIPROT","NGFR","P08138","UNIPROT","Homo sapiens","neuroblastoma cell","BTO:0000931","","Here, we provide evidence that the AB1-42 oligomers known as ADDLs (AB-derived diffusible ligands) induce p75NTR protein expression throughinsulin-like growth factor 1 receptor (IGF-1R) phosphorylation in SH-SY5Y human neuroblastoma cells.","",""
+"Insulin signaling pathway","Wnt signaling pathway","Insulin AND Wnt","24233023","yes","no","inhibiting","IRS2","Q9Y4H2","UNIPROT","CTNNB1","P35222","UNIPROT","Homo sapiens","intestine","BTO:0000648","","In addition, insulin receptor substrate 2 gene depletion blocked metformin-enhanced B-catenin translocation.","",""
+"Insulin signaling pathway","GnRH signaling pathway","Insulin AND (""GnRH"" OR ""LHRH"") AND (crosstalk OR ""cross-talk"")","15448167","yes","no","inhibiting","","","","","","","","alphaT3-1 cell","BTO:0003566","","Finally, we showed that the inhibitory effect of LHRH on IGF-1-induced PKCalpha-mediated Akt activation was associated with a marked reduction in Bad phosphorylation and a substantial decrease in the ability of IGF-1 to rescue alphaT3 cells from apoptosis induced by serum starvation.","",""
+"Insulin signaling pathway","ErbB signaling pathway","(erbb OR egfr) AND (insulin) AND (crosstalk OR cross-talk)","11244498","yes","no","activating","Igf1r","Q60751","UNIPROT","Erbb2","P70424","UNIPROT","Mus musculus","breast cancer cell","BTO:0000150","","our findings demonstrate that there is actually a hierarchical interaction between these receptors and that a functional IGF-IR is required in order to phosphorylate and thus activate ErbB-2","",""
+"Insulin signaling pathway","Hippo signaling pathway","Insulin AND Hippo AND (crosstalk OR ""cross-talk"")","22609549","yes","no","activating","Pdk1","Q9W0V1","UNIPROT","yki","Q45VV3","UNIPROT","Drosophila melanogaster","SCHNEIDER-2 cell","BTO:0001677","","We show that IIS activates Yorkie in vivo, and that Yorkie plays an important role in the ability of IIS to drive cell proliferation.","",""
+"Insulin signaling pathway","MAPK signaling pathway","Insulin AND MAPK AND (crosstalk OR ""cross-talk"")","8491186","no","","unknown","","","","","","","","","","","GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription.","",""
+"Insulin signaling pathway","Prolactin signaling pathway","Prolactin AND Insulin","24075908","yes","yes","activating","ELK1","P19419","UNIPROT","KAT5","Q92993","UNIPROT","Homo sapiens","pituitary gland tumor cell line","BTO:0000756","","Our studies suggest that insulinactivates prolactin gene transcription by activating Elk-1 that recruits the NuA4 complex to the promoter.","Transcriptional relationship",""
+"Insulin signaling pathway","VEGF signaling pathway","Insulin AND VEGF AND (crosstalk OR ""cross-talk"")","12593846","yes","no","activating","IGF1R","P08069","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","pancreatic cancer cell","BTO:0000584","","Our findings show that IGF-IR is an important growth factor receptor for cellproliferation and invasion, and VPF/VEGF expression in ASPC-1.","",""
+"Insulin signaling pathway","TGF-beta signaling pathway","Insulin AND ""TGF-B"" AND (crosstalk OR ""cross-talk"")","9115291","yes","no","inhibiting","IGFBP3","P17936","UNIPROT","TGFB1","P01137","UNIPROT","Homo sapiens","prostate gland cancer cell","BTO:0001130","","These findings suggest that IGFBP-3 induces apoptosis through a novel pathway independent of either p53 or the IGF-IGF receptor-mediated cell survival pathway and that IGFBP-3 mediates TGF-B1 induced apoptosis in PC-3 cells.","",""
+"Insulin signaling pathway","Estrogen signaling pathway","Insulin AND Estrogen AND (crosstalk OR ""cross-talk"")","11751931","yes","no","activating","Igf1r","Q60751","UNIPROT","Esr1","P19785","UNIPROT","Mus musculus","uterus","BTO:0001424","","cross-talk between IGF-1R and ER signaling pathways exists in vivo.","",""
+"Insulin signaling pathway","NF-kappa B signaling pathway","Insulin AND ""NF-kB"" AND (crosstalk OR ""cross-talk"")","21383009","yes","no","inhibiting","IGFBP3","P17936","UNIPROT","NFKBIA","P25963","UNIPROT","Homo sapiens","epithelial cell","BTO:0000414","","Our findings indicate that IGFBP-3 inhibits airway inflammation and hyper-responsiveness via an IGF-independent mechanism that involves activation of IGFBP-3R signaling and cross-talk with NF-kB signaling.","",""
+"TNF signaling pathway","Adipocytokine signaling pathway","TNF AND Adipocytokine AND (crosstalk OR ""cross-talk"")","17322064","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Adipocytokine signaling pathway","TNF AND Adipocytokine AND (crosstalk OR ""cross-talk"")","19183933","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Neurotrophin signaling pathway","TNF AND Neurotrophin AND (crosstalk OR ""cross-talk"")","18094051","yes","no","activating","TNFRSF1B","P20333","UNIPROT","MAPK3","P27361","UNIPROT","Homo sapiens","neuroblastoma cell","BTO:0000931",""," In contrast to this effect, TNF-alpha can promote neural cell survival via TNF-alpha receptor TNFR2.","",""
+"NF-kappa B signaling pathway","Jak-STAT signaling pathway","TNF AND (""Jak/STAT"" OR ""Jak-STAT"") AND (crosstalk OR ""cross-talk"")","23185365","yes","no","activating","TRAF6","Q9Y4K3","UNIPROT","STAT3","P40763","UNIPROT","Homo sapiens","HEK-293 cell","BTO:0000007","","TRAF6 augmented the ubiquitination of STAT3 and deactivated its transcriptional activity induced by IFNa stimulation or overexpressed with JAK2.","",""
+"TNF signaling pathway","Wnt signaling pathway","wnt AND TNF AND (crosstalk OR ""cross-talk"")","24501326","yes","no","inhibiting","TNF","P01375","UNIPROT","CDX2","Q99626","UNIPROT","Homo sapiens","colonic cancer cell","BTO:0000586","","it was found that TNFa induces the expression of Wnt signaling components through a downregulation of the CDX2 expression","",""
+"TNF signaling pathway","MAPK signaling pathway","MAPK AND TNF AND (crosstalk OR ""cross-talk"")","23812841","yes","no","activating","TNF","P01375","UNIPROT","DUSP4","Q13115","UNIPROT","Homo sapiens","HMVEC cell","BTO:0005737","","TNFa caused a significant suppression of a dual specificity phosphatase, DUSP4, that regulates ERK1/2 activation.","",""
+"TNF signaling pathway","Notch signaling pathway","Notch AND TNF","23028045","yes","no","inhibiting","Traf6","P70196","UNIPROT","Notch1","Q01705","UNIPROT","Mus musculus","skeletal muscle","BTO:0001103","","Collectively, our study demonstrates that specific inhibition of TRAF6 improves satellite cell activation and skeletal muscle regeneration through upregulation of Notch signaling and reducing the inflammatory repertoire.","",""
+"TNF signaling pathway","Insulin signaling pathway","TNF AND Insulin AND (crosstalk OR ""cross-talk"")","18215180","yes","no","inhibiting","","","","","","","","","","","Activation of TNF signalling via the c-Jun N-terminal kinase (JNK) can inhibit IGF-1 signalling by phosphorylation and conformational changes in insulin receptor substrate (IRS)-1 downstream of the IGF-1 receptor.","",""
+"TNF signaling pathway","Insulin signaling pathway","TNF AND Insulin AND (crosstalk OR ""cross-talk"")","22275362","yes","unknown","activating","Fam132a","Q8R2Z0","UNIPROT","","","","Mus musculus","hepatocyte","BTO:0000575","","CTRP12 improves insulin sensitivity in part by enhancing insulin signaling in the liver and adipose tissue.","",""
+"TNF signaling pathway","Insulin signaling pathway","TNF AND Insulin AND (crosstalk OR ""cross-talk"")","22275362","yes","unknown","activating","Fam132a","Q8R2Z0","UNIPROT","","","","Mus musculus","adipocyte","BTO:0000443","","CTRP12 improves insulin sensitivity in part by enhancing insulin signaling in the liver and adipose tissue.","",""
+"TNF signaling pathway","VEGF signaling pathway","TNF AND VEGF AND (crosstalk OR ""cross-talk"")","11149911","unclear","unknown","unknown","TNF","P01375","UNIPROT","F3","P13726","UNIPROT","Homo sapiens","HUVEC cell","BTO:0001949","","Since both stimuli induce the transcription factor EGR-1, which is critically involved in TF gene regulation, we used EGR-1-dependent TF induction as a model to identify potential cross-talks between the various signal transduction cascades initiated by VEGF and TNFa.","",""
+"TNF signaling pathway","TGF-beta signaling pathway","TNF AND ""TGF-B"" AND (crosstalk OR ""cross-talk"")","23500081","yes","no","activating","[MAPK8/MAPK9]","[P45983/P45984]","UNIPROT","SMAD3","P84022","UNIPROT","Homo sapiens","SNU-620 cell","BTO:0005171","","TNFa and TGF-B synergistically induced the degradation of poly(ADP-ribose) polymerase (PARP) and caspase cascade activation.","",""
+"TNF signaling pathway","Estrogen signaling pathway","TNF AND Estrogen AND (crosstalk OR ""cross-talk"")","21784129","yes","yes","activating","TNF","P01375","UNIPROT","ESR1","P03372","UNIPROT","Homo sapiens","uterine adenocarcinoma cell","BTO:0000658","","TNFa mediated ER transcriptional activity is dependent on the Extracellular Regulated Kinase (ERK) 1/2 pathway.","transcriptional",""
+"TNF signaling pathway","NF-kappa B signaling pathway","TNF AND ""NF-kB""","8530143","yes","no","activating","","","","","","","","","","","Data from our laboratory demonstrate that the TNF signal transduction pathway-mediating NF-kappa B activation involves two phospholipases, a phosphatidylcholine-specific phospholipase C (PC-PLC) and an endosomal acidic sphingomyelinase (aSMase).","",""
+"VEGF signaling pathway","MAPK signaling pathway","VEGF AND MAPK AND (crosstalk OR ""cross-talk"")","19048366","yes","no","activating","KDR","P35968","UNIPROT","MAPK3/MAPK1","P27361/P28482","UNIPROT","Homo sapiens","CHP-126 cell","BTO:0005254","","Meanwhile, VEGF and its receptor KDR were found to interact with MAPKs signaling pathways except the effect of hypoxia.","",""
+"VEGF signaling pathway","Notch signaling pathway","VEGF AND Notch AND (crosstalk OR ""cross-talk"")","12482957","yes","yes","activating","VEGFA","P15692","UNIPROT","DLL1","O00548","UNIPROT","Homo sapiens","HUVEC cell","BTO:0001949","","This study provides the first evidence for regulation of Notch/Delta gene expression by an angiogenic growth factor and insight into the critical role of Notch signaling in arteriogenesis and angiogenesis.","Transcriptional",""
+"VEGF signaling pathway","Insulin signaling pathway","VEGF AND Insulin AND (crosstalk OR ""cross-talk"")","25271320","yes","no","unknown","","","","","","","","","","","","",""
+"VEGF signaling pathway","NF-kappa B signaling pathway","VEGF AND TNF AND (crosstalk OR ""cross-talk"")","25361735","yes","yes","inhibiting","VEGFA","P15692","UNIPROT","IRF1","P10914","UNIPROT","Homo sapiens","endothelial cell","BTO:0001176","","VEGF directly suppressed TNFa-induced gene expression through negative cross-talk with the NF-kB-signaling pathway, leading to an early decrease in IFN regulatory factor 1 (IRF-1) expression and reduced phosphorylation of signal transducer and activator of transcription 1 (p-Stat1) at later times.","Transcriptional relationship",""
+"TGF-beta signaling pathway","Adipocytokine signaling pathway","TGF-B AND Adipocytokine","21723505","yes","yes","activating","Smad3","Q8BUN5","UNIPROT","Lep","P41160","UNIPROT","Mus musculus","white adipose tissue","BTO:0001456","","During a hyperinsulinemic-euglycemic clamp experiment, Smad3-/- mice exhibit enhanced insulin sensitivity, as evidenced by elevated glucose infusion rate","Transcriptional relationship",""
+"TGF-beta signaling pathway","Neurotrophin signaling pathway","TGF-B AND NGF","15367883","yes","no","activating","TGFB1","P01137","UNIPROT","NGF","P01138","UNIPROT","Homo sapiens","stellate cell","BTO:0002316","","Transforming growth factor (TGF)-beta, one of the strongest pro- fibrogenic activators of pancreatic stellate cells (PSC) induced NGF and its two receptors in an immortalized human cell line (ihPSC) and primary rat PSC (prPSC) as determined by RT-PCR, western blot, and immunofluorescence.","",""
+"TGF-beta signaling pathway","Neurotrophin signaling pathway","TGF-B AND NGF","15367883","yes","no","activating","TGFB1","P01137","UNIPROT","NGF","P01138","UNIPROT","Homo sapiens","pancreas","BTO:0000988","","Transforming growth factor (TGF)-beta, one of the strongest pro- fibrogenic activators of pancreatic stellate cells (PSC) induced NGF and its two receptors in an immortalized human cell line (ihPSC) and primary rat PSC (prPSC) as determined by RT-PCR, western blot, and immunofluorescence.","",""
+"TGF-beta signaling pathway","HIF-1 signaling pathway","HIF-1 AND TGF-B AND crosstalk","23946285","yes","yes","activating","TGFB1","P01137","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","mesangial cell","BTO:0000853","","In cultured human mesangial cells, TGF-B1 treatment increased both HIF-1a and HIF-2a expression in normoxia.","Transcriptional realtionship",""
+"TGF-beta signaling pathway","HIF-1 signaling pathway","HIF-1 AND TGF-B AND crosstalk","23946285","yes","yes","activating","TGFB1","P01137","UNIPROT","EPAS1","Q99814","UNIPROT","Homo sapiens","mesangial cell","BTO:0000853","","In cultured human mesangial cells, TGF-B1 treatment increased both HIF-1a and HIF-2a expression in normoxia.","Transcriptional realtionship",""
+"TGF-beta signaling pathway","Jak-STAT signaling pathway","(Jak-STAT OR Jak/STAT) AND (TGFB) AND (crosstalk OR cross-talk)","18024957","yes","no","inhibiting","Inhba","Q04998","UNIPROT","Stat5a","P42230","UNIPROT","Mus musculus","breast","BTO:0000149","","Smad signaling antagonizes STAT5-mediated gene transcription and mammary epithelial cell differentiation.","",""
+"TGF-beta signaling pathway","Wnt signaling pathway","TGF-B AND Wnt AND (crosstalk OR ""cross-talk"")","24003087","yes","yes","activating","SMAD2:SMAD3","Q15796:P84022","UNIPROT","CTNNB1","P35222","UNIPROT","Homo sapiens","reticulum trabeculare","BTO:0001605","","The cytokine TGF-B2 enhances cadherin-mediated cell-cell adhesion and B-catenin expression in HTM cells.","Transcriptional relationship",""
+"TGF-beta signaling pathway","GnRH signaling pathway","TGF-B AND (GnRH OR LHRH)","12385863","yes","no","activating","TGFB1","P01137","UNIPROT","GNRH1","P01148","UNIPROT","Homo sapiens","astrocyte","BTO:0000099","","A direct participation of TGFB1 and TGFB2 in the mechanisms controlling the release of LHRH has been first demonstrated in our laboratory utilizing different in vitro experimental approaches.","",""
+"TGF-beta signaling pathway","GnRH signaling pathway","TGF-B AND (GnRH OR LHRH)","12385863","yes","no","activating","TGFB2","P61812","UNIPROT","GNRH1","P01148","UNIPROT","Homo sapiens","astrocyte","BTO:0000099","","A direct participation of TGFB1 and TGFB2 in the mechanisms controlling the release of LHRH has been first demonstrated in our laboratory utilizing different in vitro experimental approaches.","",""
+"TGF-beta signaling pathway","GnRH signaling pathway","TGF-B AND (GnRH OR LHRH)","7835301","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","ErbB signaling pathway","TGF-B AND (ErbB OR EGFR)","21637380","yes","no","activating","TGFB1","P01137","UNIPROT","ERBB2","P04626","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","","TGF-B, in turn, potentiates oncogenic HER2 signaling by inducing shedding of the ErbB ligands and clustering of HER2 with integrins.","",""
+"TGF-beta signaling pathway","Toll-like receptor signaling pathway","(""Toll-like Receptor"" OR TLR) AND (TGF-B) AND (crosstalk OR cross-talk)","24801688","yes","no","activating","MAP3K7","O43318","UNIPROT","TLR9","Q9NR96","UNIPROT","Homo sapiens","B-lymphocyte","BTO:0000776","","We conclude that TAK1 is a key regulator of receptor crosstalk between BCR and TLR9","",""
+"TGF-beta signaling pathway","MAPK signaling pathway","TGF-B AND MAPK AND (crosstalk OR ""cross-talk"")","8175753","yes","no","activating","TGFB1","P01137","UNIPROT","MBP","P02686","UNIPROT","Homo sapiens","colonic cancer cell","BTO:0000586","","In both cases TGF-B1 also rapidly modulates the activities of three protein kinases, detected by their in gel kinase activity on the mitogen-activated protein kinase (MAP kinase) substrate, myelin basic protein (MBP).","",""
+"TGF-beta signaling pathway","Prolactin signaling pathway","TGF-B AND Prolactin","18335503","yes","yes","inhibiting","Smad3","Q8BUN5","UNIPROT","Csn2","P10598","UNIPROT","Mus musculus","mammary epithelial cell","BTO:0004300","","Our results show that TGF-beta suppressesprolactin-induced expression of beta-casein mRNA and protein in primary mouse mammary epithelial cells, but its effect on protein expression is more evident","Transcriptional relationship",""
+"TGF-beta signaling pathway","Insulin signaling pathway","TGF-B AND Insulin AND (crosstalk OR ""cross-talk"")","23831640","yes","yes","activating","TGFB1","P01137","UNIPROT","IGFBP3","P17936","UNIPROT","Homo sapiens","osteosarcoma cell","BTO:0000970","","TGF-B1 indirectly activated the Ras/Raf/MAPK pathway and induced the expression of IGFBP-3, an important regulator of IGF1R activity.","Transcriptional relationship",""
+"TGF-beta signaling pathway","TNF signaling pathway","TGF-B AND TNF AND (crosstalk OR ""cross-talk"")","18307974","yes","no","activating","Bmp4","Q06826","UNIPROT","","","","Rattus norvegicus","intervertebral disc","BTO:0003625","","According to these experimental results, BMP signals in the TGF-beta family were more likely to be a key factor in IVD degeneration by aging, and it was predicted that besides the involvement of catabolic factors like MMPs and ADAMS-TS, there may be a decrease in expression of anabolic factors through cross talk of signaling between TNFalpha andTGF-beta pathway in pathogenesis of disc degeneration.","",""
+"TGF-beta signaling pathway","TNF signaling pathway","TGF-B AND TNF AND (crosstalk OR ""cross-talk"")","18307974","yes","no","activating","Bmp7","G3V6W8","UNIPROT","","","","Rattus norvegicus","intervertebral disc","BTO:0003625","","According to these experimental results, BMP signals in the TGF-beta family were more likely to be a key factor in IVD degeneration by aging, and it was predicted that besides the involvement of catabolic factors like MMPs and ADAMS-TS, there may be a decrease in expression of anabolic factors through cross talk of signaling between TNFalpha andTGF-beta pathway in pathogenesis of disc degeneration.","",""
+"TGF-beta signaling pathway","VEGF signaling pathway","VEGF AND ""TGF-B"" AND (crosstalk OR ""cross-talk"")","25165192","yes","no","activating","TGFBR1","P36897","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","glioma cell","BTO:0000526","","TGF-B regulates VEGF release by glioma cells in an ALK-5-dependent manner involving SMAD2, SMAD3, and SMAD1/5/8 signaling.","",""
+"TGF-beta signaling pathway","VEGF signaling pathway","VEGF AND ""TGF-B"" AND (crosstalk OR ""cross-talk"")","25165192","yes","no","activating","TGFBR1","P36897","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","glioma cell","BTO:0000526","","TGF-B regulates VEGF release by glioma cells in an ALK-5-dependent manner involving SMAD2, SMAD3, and SMAD1/5/8 signaling.","",""
+"TGF-beta signaling pathway","NF-kappa B signaling pathway","TGF-B AND ""NF-kB"" AND (crosstalk OR ""cross-talk"")","22641218","yes","no","activating","MAP3K7","O43318","UNIPROT","NFKBIA","P25963","UNIPROT","Homo sapiens","head and neck squamous cell carcinoma cell line","BTO:0002709","","Further, TGF-B1 treatment induced sequential phosphorylation of TAK1, IKK, IkBa and RELA in human HNSCC lines.","",""
+"Estrogen signaling pathway","Adipocytokine signaling pathway","Estrogen AND Adipocytokine AND (crosstalk OR ""cross-talk"")","20410173","yes","no","activating","ESR1","P03372","UNIPROT","LEPR","P48357","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","","These data suggest that there is a bidirectional communication between LepR and ERalpha, and that neutralization and/or inactivation of LepR inhibits proliferation and viability of human breast cancer cell lines.","",""
+"Estrogen signaling pathway","Neurotrophin signaling pathway","Estrogen AND Neurotrophin AND (crosstalk OR ""cross-talk"")","14993063","yes","no","activating","","","","","","","","neuron","BTO:0000938","","To further investigate the interaction between estradiol and the neurotrophin receptors, we used a specific antisense oligonucleotide (AS) to prevent the estradiol-induced increase of TrkB.","",""
+"Estrogen signaling pathway","Jak-STAT signaling pathway","(Jak-STAT OR Jak/STAT) AND (estrogen) AND (crosstalk OR cross-talk)","23434684","yes","no","activating","","","","","","","","","","","Jak2, a member of the Jak/Stat signaling cascade, is one of the direct estradiol-dependent targets of the p/CIP/CARM1 complex","",""
+"Estrogen signaling pathway","Wnt signaling pathway","Estrogen AND Wnt AND (crosstalk OR ""cross-talk"")","24340027","yes","no","activating","ESR1/ESR2","P03372/Q92731","UNIPROT","WNT3A","P56704","UNIPROT","Homo sapiens","HEK-293 cell","BTO:0000007","","We find that the activation of estrogen receptor (ER) signaling by estradiol (estradiol) or exogenously expressed ERa in MPCs synergistically enhances Wnt3A-induced early and late osteogenic markers, as well as matrix mineralization.","",""
+"Estrogen signaling pathway","GnRH signaling pathway","Estrogen AND (GnRH OR LHRH) AND (crosstalk OR ""cross-talk"")","15140796","yes","no","activating","estradiol","hormone","hormone","LH","hormone","hormone","Rattus norvegicus","neuron","BTO:0000938","","estradiol-induced LH surge in OVX female rats","Not sure, Allison's article seems to be more intercellular",""
+"Estrogen signaling pathway","ErbB signaling pathway","Estrogen AND (ErbB OR EGFR) AND (crosstalk OR ""cross-talk"")","24063949","yes","no","activating","","","","","","","","","","","Depending on the cell type and context, the non-genomic effects of estradiol can lead to the rapid activation of many signaling molecules, such as insulin-like growth factor I receptor (IGF-IR) and epidermal growth factor receptor (EGFR)","",""
+"Estrogen signaling pathway","Toll-like receptor signaling pathway","(""Toll-like Receptor"" OR TLR) AND (estrogen) AND (crosstalk OR cross-talk)","22960279","yes","no","activating","mapk","hormone","hormone","Tlr9","Q9EQU3","UNIPROT","Mus musculus","dendritic cell","BTO:0002042","","We found that the up-regulation of cell viability, life-span, co-stimulation molecules (CD40, CD86) expression, IgM secretion, TLR9 and MCM6 expression were more significant than CpG ODN or estradiol stimulated alone.","",""
+"Estrogen signaling pathway","MAPK signaling pathway","Estrogen AND MAPK AND (crosstalk OR ""cross-talk"")","21720253","yes","no","activating","ESR1/ESR2","P03372/Q92731","UNIPROT","MAPK3","P27361","UNIPROT","Homo sapiens","uterine endometrial cancer cell","BTO:0003871","","The ratio of phosphorylated/total ERK1/2 was higher in ER-positive endometrial cancer tissues and cells (P < 0.05).","",""
+"Estrogen signaling pathway","MAPK signaling pathway","Estrogen AND MAPK AND (crosstalk OR ""cross-talk"")","21720253","yes","no","activating","ESR1/ESR2","P03372/Q92731","UNIPROT","MAPK1","P28482","UNIPROT","Homo sapiens","uterine endometrial cancer cell","BTO:0003871","","The ratio of phosphorylated/total ERK1/2 was higher in ER-positive endometrial cancer tissues and cells (P < 0.05).","",""
+"Estrogen signaling pathway","Prolactin signaling pathway","Prolactin AND HIF-1 AND (crosstalk OR ""cross-talk"")","23581407","yes","no","activating","","","","","","","Homo sapiens","MCF-7 cell","BTO:0000093","","These results suggest that prolactin/estrogen cross-talk exert beneficial effect on prolidase-dependent down regulation of HIF-1a.","",""
+"Estrogen signaling pathway","Notch signaling pathway","Estrogen AND Notch AND (crosstalk OR ""cross-talk"")","24275097","yes","yes","activating","GPER1","Q99527","UNIPROT","HES1","Q14469","UNIPROT","Homo sapiens","SK-BR-3 cell","BTO:0002419","","We show that estradiol and the GPER selective ligand G-1 induce both the y-secretase-dependent activation of Notch1 and the expression of the Notch target gene Hes-1.","",""
+"Estrogen signaling pathway","Insulin signaling pathway","Estrogen AND Insulin AND (crosstalk OR ""cross-talk"")","8876252","yes","no","activating","estradiol","hormone","hormone","Igf1","P05017","UNIPROT","Mus musculus","uterus","BTO:0001424","","Analysis of immunoprecipitates from uterine extracts revealed that estradiol enhanced tyrosine phosphorylation of the insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor substrate-1 (IRS-1) by 6 hr.","",""
+"Estrogen signaling pathway","TGF-beta signaling pathway","Estrogen AND ""TGF-B"" AND (crosstalk OR ""cross-talk"")","20207742","yes","no","inhibiting","ESR1","P03372","UNIPROT","SMAD2","Q15796","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","","Here, we show that ERalpha inhibits TGF-beta signaling by decreasing Smad protein levels.","",""
+"Estrogen signaling pathway","NF-kappa B signaling pathway","Estrogen AND ""NF-kB"" AND (crosstalk OR ""cross-talk"")","19920189","yes","no","activating","estradiol","hormone","hormone","TNF","P01375","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","","Taken together, our findings suggest that positive cross-talk between ER and NF-kB is more extensive than anticipated and that these factors may act together to promote survival of breast cancer cells and progression to a more aggressive phenotype.","",""
+"NF-kappa B signaling pathway","Neurotrophin signaling pathway","NF-kB AND Neurotrophin AND (crosstalk OR ""cross-talk"")","9517572","yes","yes","activating","Nfkb1","Q63369","UNIPROT","Ngf","P25427","UNIPROT","Rattus norvegicus","microglia","BTO:0000078","","In conclusion, NF-kappaB-controlled NGF expression by activated microglia appears to contribute to the cross-talk between the immune and nervous systems during inflammation in the CNS.","",""
+"NF-kappa B signaling pathway","HIF-1 signaling pathway","NF-kB AND ""HIF-1"" AND (crosstalk OR ""cross-talk"")","21187066","yes","yes","inhibiting","NFKB1","P19838","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","MG-63 cell","BTO:0001596","","It was concluded that NF-kB-mediated inflammatory signaling is able to block HIF-1a transactivation at HRE-encoding genes by direct competition for p300 binding at the promoter.","Transcriptional",""
+"NF-kappa B signaling pathway","HIF-1 signaling pathway","NF-kB AND ""HIF-1"" AND (crosstalk OR ""cross-talk"")","21187066","yes","yes","inhibiting","NFKB1","P19838","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","hFOB 1.19 cell","BTO:0005224","","It was concluded that NF-kB-mediated inflammatory signaling is able to block HIF-1a transactivation at HRE-encoding genes by direct competition for p300 binding at the promoter.","Transcriptional",""
+"NF-kappa B signaling pathway","HIF-1 signaling pathway","NF-kB AND ""HIF-1"" AND (crosstalk OR ""cross-talk"")","21187066","yes","yes","inhibiting","NFKB1","P19838","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","MC3T3-E1 cell","BTO:0001957","","It was concluded that NF-kB-mediated inflammatory signaling is able to block HIF-1a transactivation at HRE-encoding genes by direct competition for p300 binding at the promoter.","Transcriptional",""
+"NF-kappa B signaling pathway","Jak-STAT signaling pathway","JAK-STAT AND NF-kB","23185365","yes","no","inhibiting","TRAF6","Q9Y4K3","UNIPROT","STAT3","P40763","UNIPROT","Homo sapiens","HEK-293 cell","BTO:0000007","","The ubiquitin ligase TRAF6 negatively regulates the JAK-STAT signaling pathway by binding to STAT3 and mediating its ubiquitination","",""
+"NF-kappa B signaling pathway","Jak-STAT signaling pathway","Jak/STAT AND NF-kB AND crosstalk","18441519","yes","no","activating","Nfkb1","Q63369","UNIPROT","Jak2","Q62689","UNIPROT","Rattus norvegicus","muscle fibre","BTO:0000888","","cardiomyocytes possess an apoptosis-resistant property as a cytoprotection mechanism which is likely conferred by mutual transactivation between AKT/NF-kB and JAK2/STAT3, a novel crosstalk between the two signaling pathways within the networking governing the cell fate","",""
+"NF-kappa B signaling pathway","Jak-STAT signaling pathway","Jak/STAT AND NF-kB AND crosstalk","18441519","yes","no","activating","Nfkb1","Q63369","UNIPROT","Stat3","P52631","UNIPROT","Rattus norvegicus","muscle fibre","BTO:0000888","","cardiomyocytes possess an apoptosis-resistant property as a cytoprotection mechanism which is likely conferred by mutual transactivation between AKT/NF-kB and JAK2/STAT3, a novel crosstalk between the two signaling pathways within the networking governing the cell fate","",""
+"NF-kappa B signaling pathway","Wnt signaling pathway","wnt AND (""NF kappa B"") AND (crosstalk OR ""cross-talk"")","22160170","yes","no","activating","","","","","","","Mesocricetus auratus","buccal mucosa cancer cell","BTO:0005769","","Abrogation of Wnt signaling by ellagic acid was also associated with inactivation of NF-kB and modulation of key components of the mitochondrial apoptotic network.","",""
+"NF-kappa B signaling pathway","GnRH signaling pathway","(gnRH OR LHRH) AND (NF-kB)","23636330","yes","yes","inhibiting","Ikbkb","O88351","UNIPROT","Gnrh1","P13562","UNIPROT","Mus musculus","hypothalamus","BTO:0000614","","We found that ageing was associated with reduced hypothalamic Gnrh1 mRNA, and this change was reversed by IKK-β and NF-κB inhibition but enhanced by their activation.","Appears to be a TF-gene interaction",""
+"NF-kappa B signaling pathway","Notch signaling pathway","NF-kB AND Notch AND (crosstalk OR ""cross-talk"")","22056382","yes","no","activating","Ikbkb","O88351","UNIPROT","Hes1,Hey1","P35428,Q9WV93","UNIPROT","Mus musculus","pancreatic cancer cell","BTO:0000584","","Thus, crosstalk between TNFa/Ikk2 and Notch sustains the intrinsic inflammatory profile of transformed cells.","Sounds like transcriptional because cites Hes1 and Hey1 genes, but perhaps effect of Ikk2 interaction with Notch",""
+"NF-kappa B signaling pathway","Insulin signaling pathway","NF-kB AND Insulin AND (crosstalk OR ""cross-talk"")","23891856","yes","no","inhibiting","IL1B","P01584","UNIPROT","IRS1","P35568","UNIPROT","Homo sapiens","trophoblast","BTO:0001079","","In conclusion, IL-1B inhibited the insulin signaling pathway by inhibiting IRS-1 signaling","",""
+"NF-kappa B signaling pathway","VEGF signaling pathway","NA","21410066","unclear","no","activating","NFKB1","P19838","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","Hep-G2 cell","BTO:0000599","","The inhibitory effect of resveratrol on VEGF activity may occur partly through suppression of the activation of NF-kappa B in HepG2 cells.","Could be transcriptional",""
+"NF-kappa B signaling pathway","Estrogen signaling pathway","NFkB AND Estrogen AND (crosstalk OR ""cross-talk"")","21839804","yes","yes","inhibiting","NFKB1","P19838","UNIPROT","ESR2","Q92731","UNIPROT","Homo sapiens","granulosa cell","BTO:0000542","","These data are consistent with a role for NFκB signalling in granulosa cells and indicate that ERβ signalling may be modulated by NFκB, perhaps through mutual transrepression.","",""
+"HIF-1 signaling pathway","GnRH signaling pathway","(gnRH OR LHRH) AND HIF-1","24035332","","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","GnRH signaling pathway","(gnRH OR LHRH) AND (Jak/STAT OR Jak-STAT)","21209203","","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","Toll-like receptor signaling pathway","(gnRH OR LHRH) AND (TLR OR Toll-like Receptor)","24719525","no","","unknown","","","","","","","","","","","","",""
+"Progesterone-mediated oocyte maturation","Melanogenesis","Progesterone AND Melanogenesis","19140277","no","","","","","","","","","","","","","","Abstract only",""
+"Melanogenesis","Progesterone-mediated oocyte maturation","Progesterone AND Melanogenesis","9266606","unclear","","","","","","","","","","","","","","Abstract only",""
+"Melanogenesis","Progesterone-mediated oocyte maturation","Progesterone AND Melanogenesis","11031360","no","","","","","","","","","","","","","","LAM cells: associated with incomplete melanogenesis; reactive with antibodies against estrogen and progesterone receptors",""
+"Progesterone-mediated oocyte maturation","Melanogenesis","Progesterone AND Melanogenesis","9266606","unclear","","","","","","","","","","","","","","Abstract only",""
+"Melanogenesis","Thyroid hormone synthesis","""Thyroid hormone"" AND Melanogenesis ","21886774","no","","","","","","","","","","","","","","It is unknown whether the toxic effects of PTU are through inhibition of thyroid hormone.\r\nPTU inhibits melanogenesis",""
+"Thyroid hormone synthesis","Melanogenesis","""Thyroid hormone"" AND Melanogenesis","21886774","no","","","","","","","","","","","","","","At a concentration of 0.003%, PTU added prior to 24 hpf decreased thyroxine in thyroid follicles at 96 hpf.\r\nPTU inhibits melanogenesis",""
+"mTOR signaling pathway","Melanogenesis","mTOR AND Melanogenesis","15895362","yes","unknown","inhibiting","Rps6kb1","Q8BSK8","UNIPROT","","","","Mus musculus","B-16 cell","BTO:0000576","cancer","The activity of mammalian target of rapamycin (mTOR) is essential for phosphorylation of S6K1 and the treatment malanoma cells with rapamycin, a potent inhibitor of mTOR effectively induced melanogenesis","",""
+"Melanogenesis","mTOR signaling pathway","mTOR AND Melanogenesis","15895362","no","","","","","","","","","","","","","","other direction",""
+"mTOR signaling pathway","Melanogenesis","mTOR AND Melanogenesis","22577264","yes","yes","activating","","","","TYR","P14679","UNIPROT","Homo sapiens","MNT-1 cell","BTO:0002946","cancer","Rapamycin-induced melanin formation may be mediated through the up-regulation of TYR protein and activity.","",""
+"Melanogenesis","mTOR signaling pathway","mTOR AND Melanogenesis","22577264","no","","","","","","","","","","","","","","other direction",""
+"MAPK signaling pathway","Melanogenesis","mTOR AND Melanogenesis","23792203","yes","yes","inhibiting","Mapk3/Mapk1","Q63844/P63085","UNIPROT","Tyr,Mitf","P11344,Q08874","UNIPROT","Mus musculus","Mel-Ab cell","BTO:0003944","immortalized","These findings suggest that activation of ERK by GGA reduces melanin synthesis in Mel-Ab cells through downregulation of MITF and tyrosinase expression.","",""
+"Melanogenesis","MAPK signaling pathway","mTOR AND Melanogenesis","23792203","no","","","","","","","","","","","","","","other direction",""
+"mTOR signaling pathway","Melanogenesis","mTOR AND Melanogenesis","21838918","unclear","unknown","activating","Mtor","Q9JLN9","UNIPROT","SPC","molecule","molecule","Mus musculus","Mel-Ab cell","BTO:0003944","immortalized","Treatment with the mTOR inhibitor rapamycin eliminated decreases in melanin and LC3 II levels by SPC","Treatment with the mTOR inhibitor rapamycin eliminated decreases in melanin and LC3 II levels by SPC. SPC treatment also reduces MIFT expression, but the relationship between the pathways remains unclear.",""
+"Melanogenesis","mTOR signaling pathway","mTOR AND Melanogenesis","21838918","no","","","","","","","","","","","","","","other direction",""
+"Melanogenesis","mTOR signaling pathway","mTOR AND Melanogenesis","24361963","no","","","","","","","","","","","","","","",""
+"mTOR signaling pathway","Melanogenesis","mTOR AND Melanogenesis","24361963","no","","","","","","","","","","","","","","",""
+"mTOR signaling pathway","Melanogenesis","mTOR AND Melanogenesis","20073603","no","","","","","","","","","","","","","","",""
+"Melanogenesis","Adipocytokine signaling pathway","Adipocytokine AND Melanogenesis ","22955981","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","Melanogenesis","Adipocytokine AND Melanogenesis","22955981","no","","","","","","","","","","","","","","",""
+"Adherens junction","Adipocytokine signaling pathway","Adherens junction Adipocytokine","18537097","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","Adherens junction","Adherens junction Adipocytokine","18537097","no","","","","","","","","","","","","","","",""
+"Adherens junction","Apoptosis","Adherens Apoptosis pathway","26300629","no","","","","","","","","","","","","","","",""
+"Apoptosis","Adherens junction","Adherens Apoptosis pathway","26300629","no","","","","","","","","","","","","","","",""
+"Adherens junction","Apoptosis","Adherens Apoptosis pathway","25952901","unclear","","","","","","","","","","","","","Dynamic studies of Src activation, VP and apoptosis revealed that ISM induces VP directly via Src activation while apoptosis contributes indirectly only after prolonged treatment.","Did not have access to full text.",""
+"Adherens junction","Apoptosis","Adherens Apoptosis pathway","25725070","unclear","unknown","inhibiting","","","","","","","Drosophila melanogaster","compound eye","BTO:0001921","development","hus, in Magi mutants, the defective AJs would lead to apoptosis failure because the IOCs did not attain their position in the ‘death zone’ (Monserrate and Brachmann, 2007) to receive the killing signal.","Loss of adherens junctions leads to apoptosis but not sure about mechanism.",""
+"Apoptosis","Adherens junction","Adherens Apoptosis pathway","25725070","no","","","","","","","","","","","","","","",""
+"Adherens junction","Apoptosis","Adherens Apoptosis pathway","25546411","unclear","","inhibiting","","","","","","","","endothelial cell","BTO:0001176","","Our findings suggest that the novel protective mechanisms of Ang-1 on endothelium are achieved by strengthening endothelial cell junctions and reducing endothelial cell death after AGE injury.","Ang-1 strengthens endothelial cell junctions and also regulates PIK3 to reduce apoptosis, but not sure if Ang-1 is considered a part of the adherens junction pathway.",""
+"Adherens junction","Apoptosis","Adherens Apoptosis pathway","25488805","yes","no","inhibiting","actin","Other","Other","PIK3CA","P42336","UNIPROT","Homo sapiens","HUVEC cell","BTO:0001949","","In summary, exposure to a low dose of DEP actin triggers cytoskeleton depolarization, reduces PI3K/Akt activity, and induces a p53/Mdm2 feedback loop, and a high dose causes apoptosis by depleting Mdm2.","",""
+"Apoptosis","Adherens junction","Adherens Apoptosis pathway","25488805","no","","","","","","","","","","","","","","",""
+"Adherens junction","Hedgehog signaling pathway","Adherens junction AND Hedgehog AND crosstalk","23010341","no","","","","","","","","","","","","","","Reports intercellular crosstalk.",""
+"Hedgehog signaling pathway","Adherens junction","Adherens junction AND Hedgehog AND crosstalk ","23010341","no","","","","","","","","","","","","","","Reports intercellular crosstalk",""
+"Notch signaling pathway","Hedgehog signaling pathway","Adherens junction AND Hedgehog AND pathway","25472739","unclear","unknown","","","","","","","","","","","","A less robust outcome was observed with manipulation of Hedgehog levels, though consistent with a role in neural stem cell survival or proliferation. Inhibition of both pathways resulted in an additive effect.","Only had access to abstract.",""
+"Hedgehog signaling pathway","Notch signaling pathway","Adherens junction AND Hedgehog AND pathway","25472739","unclear","unknown","","","","","","","","","","","","A less robust outcome was observed with manipulation of Hedgehog levels, though consistent with a role in neural stem cell survival or proliferation. Inhibition of both pathways resulted in an additive effect.","Only had access to abstract.",""
+"Adherens junction","Hedgehog signaling pathway","Adherens AND Hedgehog AND pathway","22086851","no","no","","","","","","","","","","","","Further mechanistic analysis revealed that GLI1 directly regulated the transcription of E-cadherin, a key determinant of epithelial tissue organization.","other direction",""
+"Hedgehog signaling pathway","Adherens junction","Adherens AND Hedgehog AND pathway","22086851","yes","yes","activating","GLI1","P08151","UNIPROT","CDH1","P12830","UNIPROT","Homo sapiens","pancreas","BTO:0000988","cancer","Further mechanistic analysis revealed that GLI1 directly regulated the transcription of E-cadherin, a key determinant of epithelial tissue organization.","",""
+"MAPK signaling pathway","Hedgehog signaling pathway","Adherens AND Hedgehog AND pathway","21502507","yes","yes","inhibiting","Rhoa","Q9QUI0","UNIPROT","Gli1","P47806","UNIPROT","Mus musculus","midbrain","BTO:0000138","","Furthermore, RhoA-deficient neural progenitor cells exhibit accelerated proliferation, reduction of cell- cycle exit, and increased expression of downstream target genes of the hedgehog pathway...We found that the expression of Gli1 and Fgf15 was significantly elevated in the RhoA-deficient midbrain.","Rho is present in several signaling pathways including cAMP, Ras, Chemokine, Neurotrophin, Wnt, TGF-Beta.",""
+"Hedgehog signaling pathway","MAPK signaling pathway","Adherens AND Hedgehog AND pathway","21502507","no","","","","","","","","","","","","","","other direction",""
+"Hippo signaling pathway","Notch signaling pathway","Adherens AND Hedgehog AND pathway","15037549","no","no","activating","","","","","","","Mus musculus","brain","BTO:0000142","embryonic","This asymmetric Numb localization was not observed in the Lgl1–/– cells.","",""
+"Notch signaling pathway","Hippo signaling pathway","Adherens AND Hedgehog AND pathway","15037549","no","","","","","","","","","","","","","","",""
+"Adherens junction","Notch signaling pathway","Adherens junction AND Hedgehog AND pathway","20362667","unclear","","","","","","","","","Danio rerio","retina","BTO:0001175","","We found that the neurogenic defects in the ncad and nok mutant retinas are suppressed by the blockade of the Notch signaling pathway and modulated by the Hh-PKA signaling pathway, suggesting that these signaling pathways are involved in the generation of neurogenic defects in the ncad and nok mutant retinas.","Not sure what this is article is saying.",""
+"Notch signaling pathway","Adherens junction","Adherens junction AND Hedgehog AND pathway","20362667","unclear","","","","","","","","","Danio rerio","retina","BTO:0001175","","We found that both signaling pathways are involved in the generation of neurogenic defects in the ncad and nok mutant retinas.","Not sure.",""
+"Adherens junction","Hedgehog signaling pathway","Adherens junction AND Hedgehog AND pathway","20362667","unclear","unknown","","","","","","","","","","","","We found that both signaling pathways are involved in the generation of neurogenic defects in the ncad and nok mutant retinas...Although the level of BrdU incorporation in the ncad and nok mutant retinas was not elevated by the smu mutation, the inhibition of Hh signaling enhances the generation of neurogenic defects in the retinas of both mutants.","",""
+"Hedgehog signaling pathway","Adherens junction","Adherens junction AND Hedgehog AND pathway","20362667","unclear","unknown","","","","","","","","","","","","Although the level of BrdU incorporation in the ncad and nok mutant retinas was not elevated by the smu mutation, the inhibition of Hh signaling enhances the generation of neurogenic defects in the retinas of both mutants.","",""
+"Hedgehog signaling pathway","Adherens junction","Adherens junction AND Hedgehog AND pathway","19815628","no","","","","","","","","","","","","","","",""
+"Adherens junction","Hedgehog signaling pathway","Adherens junction AND Hedgehog AND pathway","19815628","no","","","","","","","","","","","","","","",""
+"Adherens junction","Hedgehog signaling pathway","Adherens junction AND Hedgehog AND pathway","16543460","yes","unknown","inhibiting","Ctnna1","P26231","UNIPROT","Smo","P56726","UNIPROT","Mus musculus","brain","BTO:0000142","","We show here that central nervous system-specific deletion of the essential adherens junction gene, αE-catenin, causes abnormal activation of the hedgehog pathway resulting in shortening of the cell cycle, decreased apoptosis and subsequent massive cortical hyperplasia.","",""
+"Hedgehog signaling pathway","Adherens junction","Adherens junction AND Hedgehog AND pathway","16543460","no","","","","","","","","","","","","","","",""
+"Hedgehog signaling pathway","Adherens junction","Adherens junction AND Hedgehog AND pathway","19736564","unclear","","","","","","","","","Mus musculus","iPS","","","aken together, we proposed that there is a core developmental signaling network necessary for pluripotency, with TGF-beta, Hedgehog, Wnt, p53 as repressive (Yin) regulators and Jak-STAT, cell cycle, focal adhesion, adherens junction as active (Yang) ones; and Yamanaka factors synergistically regulate them in a Yin-Yang balanced way to induce pluripotency.","",""
+"Adherens junction","Hedgehog signaling pathway","Adherens junction AND Hedgehog AND pathway","19736564","","","","","","","","","","","","","","aken together, we proposed that there is a core developmental signaling network necessary for pluripotency, with TGF-beta, Hedgehog, Wnt, p53 as repressive (Yin) regulators and Jak-STAT, cell cycle, focal adhesion, adherens junction as active (Yang) ones; and Yamanaka factors synergistically regulate them in a Yin-Yang balanced way to induce pluripotency.","",""
+"Adherens junction","Insulin signaling pathway","Adherens AND Insulin AND pathway","25751637","no","","","","","","","","","","","","","","Genome-wide analysis; does not report specific pathway-pathway interactions","Pathways in insulin signaling, the adherens junction, and cancers were among the top 5 pathways in both tissues."
+"Insulin signaling pathway","Adherens junction","Adherens AND Insulin AND pathway","25751637","no","","","","","","","","","","","","","","Genome-wide analysis; does not report specific pathway-pathway interactions","Pathways in insulin signaling, the adherens junction, and cancers were among the top 5 pathways in both tissues."
+"Insulin signaling pathway","Adherens junction","Adherens AND Insulin AND pathway","24645679","no","","","","","","","","","","","","","","Sounds like there is some relationship between pathways, but goes through Wnt first.","This effect takes place in a Wnt-independent manner because TSH and IGF-1, through the activation of protein kinase A and protein kinase B/Akt, phosphorylate β-catenin at S552 and S675, which results in β-catenin release from E-cadherin at the adherens junctions."
+"Adherens junction","Insulin signaling pathway","Adherens AND Insulin AND pathway","24645679","no","","","","","","","","","","","","","","","This effect takes place in a Wnt-independent manner because TSH and IGF-1, through the activation of protein kinase A and protein kinase B/Akt, phosphorylate β-catenin at S552 and S675, which results in β-catenin release from E-cadherin at the adherens junctions."
+"Wnt signaling pathway","Adherens junction","Wnt AND Adherens AND pathway","24645679","no","","","","","","","","","","","","","","",""
+"Adherens junction","Wnt signaling pathway","Wnt AND Adherens AND pathway","24645679","no","no","unknown","","","","","","","","","","","","","This effect takes place in a Wnt-independent manner because TSH and IGF-1, through the activation of protein kinase A and protein kinase B/Akt, phosphorylate β-catenin at S552 and S675, which results in β-catenin release from E-cadherin at the adherens junctions."
+"Thyroid hormone synthesis","Wnt signaling pathway","Wnt AND Adherens AND pathway","24645679","yes","no","activating","Prkaca","P27791","UNIPROT","Ctnnb1","Q9WU82","UNIPROT","Rattus norvegicus","PCCL-3 cell","BTO:0003800","","This effect takes place in a Wnt-independent manner because TSH and IGF-1, through the activation of protein kinase A and protein kinase B/Akt, phosphorylate β-catenin at S552 and S675, which results in β-catenin release from E-cadherin at the adherens junctions.","TSH causes PKA to phosphorylate beta-catenin",""
+"Thyroid hormone synthesis","Wnt signaling pathway","Wnt AND Adherens AND pathway","24645679","yes","no","activating","Prkaca","P27791","UNIPROT","Ctnnb1","Q9WU82","UNIPROT","Rattus norvegicus","FRTL-5 cell","BTO:0001875","","This effect takes place in a Wnt-independent manner because TSH and IGF-1, through the activation of protein kinase A and protein kinase B/Akt, phosphorylate β-catenin at S552 and S675, which results in β-catenin release from E-cadherin at the adherens junctions.","TSH causes PKA to phosphorylate beta-catenin",""
+"Wnt signaling pathway","Thyroid hormone synthesis","Wnt AND Adherens AND pathway","24645679","no","","","","","","","","","","","","","","other direction",""
+"Insulin signaling pathway","Wnt signaling pathway","Wnt AND Adherens AND pathway","24645679","yes","no","activating","Igf1","P08025","UNIPROT","Ctnnb1","Q9WU82","UNIPROT","Rattus norvegicus","PCCL-3 cell","BTO:0003800","","This effect takes place in a Wnt-independent manner because TSH and IGF-1, through the activation of protein kinase A and protein kinase B/Akt, phosphorylate β-catenin at S552 and S675, which results in β-catenin release from E-cadherin at the adherens junctions.","IGF-1 (with the help of TSH) causes PKA to phosphorylate beta-catenin",""
+"Insulin signaling pathway","Wnt signaling pathway","Wnt AND Adherens AND pathway","24645679","yes","no","activating","Igf1","P08025","UNIPROT","Ctnnb1","Q9WU82","UNIPROT","Rattus norvegicus","FRTL-5 cell","BTO:0001875","","This effect takes place in a Wnt-independent manner because TSH and IGF-1, through the activation of protein kinase A and protein kinase B/Akt, phosphorylate β-catenin at S552 and S675, which results in β-catenin release from E-cadherin at the adherens junctions.","IGF-1 (with the help of TSH) causes PKA to phosphorylate beta-catenin",""
+"Wnt signaling pathway","Insulin signaling pathway","Wnt AND Adherens AND pathway","24645679","no","","","","","","","","","","","","","","",""
+"Adherens junction","Insulin signaling pathway","Adherens AND Insulin AND pathway","22924026","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","Adherens junction","Adherens AND Insulin AND pathway","22924026","no","","","","","","","","","","","","","","",""
+"Adherens junction","ErbB signaling pathway","Adherens AND ErbB AND pathway","17593333","yes","unknown","inhibiting","ERBB2","P04626","UNIPROT","CDH5","P33151","UNIPROT","Homo sapiens","breast cancer cell","BTO:0000150","MCF-7","Our data suggest that HER2 induction of EC retraction involves both down-regulation of VE-cadherin and dissociation of catenins. ","",""
+"ErbB signaling pathway","Adherens junction","Adherens AND ErbB AND pathway","17593333","no","","","","","","","","","","","","","","other direction",""
+"Adherens junction","ErbB signaling pathway","Adherens AND ErbB AND pathway","16891313","no","","","","","","","","","","","","","","Mucins not part of the junction",""
+"ErbB signaling pathway","Adherens junction","Adherens AND ErbB AND pathway","16891313","no","","","","","","","","","","","","","","",""
+"Adherens junction","Melanogenesis","Adherens AND Melanogenesis AND pathway","24790137","no","no","","","","","","","","","","","","","Here, cKit activation is affecting VE-cadherin internalization, not regulating transcription.","We demonstrated that SCF binds to and activates the cKit receptor in endothelial cells, thereby increasing the internalization of vascular endothelial-cadherin and enhancing extravasation of dyes to a similar extent as vascular endothelial growth factor."
+"Melanogenesis","Adherens junction","Adherens AND Melanogenesis AND pathway","24790137","no","","","","","","","","","","","","","","cKit is affecting internalization of VE-cadherin, not transcription","We demonstrated that SCF binds to and activates the cKit receptor in endothelial cells, thereby increasing the internalization of vascular endothelial-cadherin and enhancing extravasation of dyes to a similar extent as vascular endothelial growth factor."
+"Adherens junction","HIF-1 signaling pathway","Adherens AND HIF-1 AND pathway","19073886","no","","","","","","","","","","","","","","Other direction",""
+"HIF-1 signaling pathway","Adherens junction","Adherens AND HIF-1 AND pathway","16585181","yes","yes","activating","VHL","P40337","UNIPROT","CDH1","P12830","UNIPROT","Homo sapiens","renal cell carcinoma cell","BTO:0000037","cancer","Here, we show that VHL inactivation in precancerous lesions in kidneys from patients with VHL disease correlates with marked down-regulation of the intercellular adhesion molecule E-cadherin.","",""
+"Adherens junction","HIF-1 signaling pathway","Adherens AND HIF-1 AND pathway","16585181","no","","","","","","","","","","","","","","other direction",""
+"Adherens junction","HIF-1 signaling pathway","Adherens AND HIF-1 AND pathway","19073886","no","","","","","","","","","","","","","","other direction",""
+"HIF-1 signaling pathway","Adherens junction","Adherens AND HIF-1 AND pathway","19073886","yes","no","","VHL","P40337","UNIPROT","CDH1","P12830","UNIPROT","Homo sapiens","renal cell carcinoma cell","BTO:0000037","cancer","","cites 16585181",""
+"HIF-1 signaling pathway","Adherens junction","Adherens AND HIF-1 AND pathway","18805433","no","","","","","","","","","","","","","","effects of anti-cancer drug",""
+"Adherens junction","HIF-1 signaling pathway","Adherens AND HIF-1 AND pathway","18805433","no","","","","","","","","","","","","","","effects of anti-cancer drug",""
+"Adherens junction","Estrogen signaling pathway","Adherens AND Estrogen AND pathway","10403573","no","","","","","","","","","","","","","","Other direction",""
+"Estrogen signaling pathway","Adherens junction","Adherens AND Estrogen AND pathway","10403573","yes","unknown","inhibiting","Esr1","P06211","UNIPROT","Cdh2","Q9Z1Y3","UNIPROT","Rattus norvegicus","GH3 cell","BTO:0001410","","E2 reduced surface N-cadherin protein to barely detectable levels, whereas ICI 182,780-treated cells displayed abundant punctate immunoreactive N-cadherin...These results provide the first demonstration of the regulation of N-cadherin-mediated cell-cell adhesion by the estrogen receptor (ER) signaling pathway in pituitary somatolactotrophs through the coordinate regulation of N-cadherin and beta-catenin expression. ","E2 also regulates beta-catenin expression",""
+"TNF signaling pathway","Adherens junction","Adherens junction AND TNF AND pathway","23375756","yes","unknown","inhibiting","Casp3","P55213","UNIPROT","","","","Rattus norvegicus","HLMVEC cell","BTO:0003599","","TRAIL + LY294002, but not TRAIL alone, induced monolayer hyperpermeability (P < .05), and caspase-3 activity (P < .05), and disrupted the adherens junctions. Z-DEVD-FMK attenuated hyperpermeability and protected the adherens junctions.","PI3K inhibitor needed for TRAIL to disrupt adherens junctions; more CASP3 activity disrupts adherens junctions",""
+"Adherens junction","TNF signaling pathway","Adherens junction AND TNF AND pathway","23375756","no","","","","","","","","","","","","","","",""
+"Adherens junction","Hippo signaling pathway","Adherens AND Hippo AND pathway","25624491","yes","unknown","inhibiting","shg","Q24298","UNIPROT","yki","Q45VV3","UNIPROT","Drosophila melanogaster","imaginal disc","BTO:0004658","disc development","Yki activity was cell-autonomously decreased but non-cell-autonomously elevated in tissues where the AJ components E-cadherin (E-cad) or α-catenin (α-cat) were knocked down.","alpha-catenin is protein A too",""
+"Hippo signaling pathway","Adherens junction","Adherens AND Hippo AND pathway","25624491","no","","","","","","","","","","","","","","other direction",""
+"Adherens junction","Hippo signaling pathway","Adherens AND Hippo AND pathway","25624491","yes","unknown","activating","scrib","Q7KRY7","UNIPROT","yki","Q45VV3","UNIPROT","Drosophila melanogaster","imaginal disc","BTO:0004658","disc development","In contrast, scrib knockdown caused a predominantly cell-autonomous activation of Yki.","Paper states that scrib is a component of Adherens Junction, but scrib is listed in hippo pathway.",""
+"Adherens junction","Hippo signaling pathway","Adherens AND Hippo AND pathway","26317911","no","","","","","","","","","","","","","","Ethanol disrupts connexin43 which is part of a gap junction, not adherens.","Taken together, the results provide evidence that cells exposed directly to ethanol show 1) impaired cell-cell adherence/communication, 2) decreased cellular mechanotransduction by the cytoskeleton, and 3) a suppressed hippo-YAP pathway. Suppression of hippo-YAP pathway signaling should be effective in maintaining cellular homeostasis in cardiomyocytes exposed to ethanol."
+"Hippo signaling pathway","Adherens junction","Adherens AND Hippo AND pathway","26317911","no","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","Adherens junction","Adherens AND Hippo AND pathway","26317911","no","","","","","","","","","","","","","","Protein-Protein interactions between Amot and AJs, but no downstream effect on AJ signaling.","In the nonpolar inner cells, Amot localizes to adherens junctions (AJs), and cell-cell adhesion activates the Hippo pathway. In the outer cells, the cell polarity sequesters Amot from basolateral AJs to apical domains, thereby suppressing Hippo signaling."
+"Adherens junction","Hippo signaling pathway","Adherens AND Hippo AND pathway","26317911","no","","","","","","","","","","","","","","Localization at AJs, but proteins causing downstream effect are Hippo proteins.","In the nonpolar inner cells, Amot localizes to adherens junctions (AJs), and cell-cell adhesion activates the Hippo pathway. In the outer cells, the cell polarity sequesters Amot from basolateral AJs to apical domains, thereby suppressing Hippo signaling."
+"Adherens junction","TGF-beta signaling pathway","Adherens AND TGF-beta AND crosstalk","25702679","no","","","","","","","","","","","","","","Different definition of crosstalk.",""
+"TGF-beta signaling pathway","Adherens junction","Adherens AND TGF-beta AND crosstalk","25702679","no","","","","","","","","","","","","","","Different definition of crosstalk.",""
+"Melanogenesis","ErbB signaling pathway","Melanogenesis AND ErbB","14666720","no","","","","","","","","","","","","","","","The results of our large study indicate that the HER-2/neu onco-protein neither has a role in melanogenesis nor is a potential target for clinical trials with monoclonal antibody therapy."
+"ErbB signaling pathway","Melanogenesis","Melanogenesis AND ErbB","14666720","no","","","","","","","","","","","","","","",""
+"Melanogenesis","ErbB signaling pathway","Melanogenesis AND ErbB","14634801","no","","","","","","","","","","","","","","","HER-2/neu has no role in melanogenesis."
+"ErbB signaling pathway","Melanogenesis","Melanogenesis AND ErbB","14634801","no","","","","","","","","","","","","","","",""
+"Melanogenesis","Estrogen signaling pathway","Melanogenesis AND Estrogen","25439299","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Melanogenesis","Melanogenesis AND Estrogen","25439299","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Melanogenesis","Melanogenesis AND Estrogen","23574448","yes","unknown","activating","tamoxifen","drug","drug","","","","Homo sapiens","melanocyte","BTO:0000847","adult/normal","According to the results, even in such a short treatment period, tamoxifen and 4-hydroxy-tamoxifen promoted melanin extrusion and they seem to act as melanogenesis stimulators at the molecular level.","",""
+"Melanogenesis","Estrogen signaling pathway","Melanogenesis AND Estrogen","23574448","no","","","","","","","","","","","","","","other direction",""
+"Estrogen signaling pathway","Melanogenesis","Melanogenesis AND Estrogen","22696060","unclear","","","","","","","","","","","","","Collectively, upregulation of PDZK1 could have an important role in the development of melasma in connection with estrogen through NHE, CFTR, and SLC26A3.","",""
+"Melanogenesis","Estrogen signaling pathway","Melanogenesis AND Estrogen","22696060","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Melanogenesis","Melanogenesis AND Estrogen","19968822","unclear","","","","","","","","","","","","","These findings suggest that downregulation of H19 and a sufficient dose of estrogen might be involved in the development of melasma.","",""
+"Estrogen signaling pathway","Melanogenesis","Melanogenesis AND Estrogen","21597196","no","","","","","","","","","","","","","Biochanin A dose-dependently inhibited both melanogenesis and cellular tyrosinase activity in B16 cells and in zebrafish embryos.","Biochanin A is a phytoestrogen",""
+"Melanogenesis","Estrogen signaling pathway","Melanogenesis AND Estrogen","21597196","no","","","","","","","","","","","","","","",""
+"Melanogenesis","GnRH signaling pathway","Melanogenesis AND GnRH","3920061","no","","","","","","","","","","","","","","","The combined MSH-insulin stimulation of anchorage-independent growth was specific, since the effect could not be mimicked by epidermal growth factor (EGF), gonadotropin-releasing hormone (GRH), luteinizing hormone (LH), nerve growth factor (NGF) or platelet-derived growth factor (PDGF)."
+"GnRH signaling pathway","Melanogenesis","Melanogenesis AND GnRH","3920061","no","","","","","","","","","","","","","","",""
+"Melanogenesis","HIF-1 signaling pathway","Melanogenesis AND HIF-1","24966027","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","Melanogenesis","Melanogenesis AND HIF-1","24966027","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","Melanogenesis","Melanogenesis AND HIF-1","18834862","no","","","","","","","","","","","","","","","Signaling by the receptor for stem cell factor (SCF), c-Kit, is of major importance for hematopoiesis, melanogenesis and reproduction, and the biological responses are commonly proliferation and cell survival."
+"Melanogenesis","HIF-1 signaling pathway","Melanogenesis AND HIF-1","18834862","no","","","","","","","","","","","","","","",""
+"Notch signaling pathway","ErbB signaling pathway","Notch AND ErbB AND pathway","24970336 ","no","no","","","","","","","","","","","","","The full article was not read because the abstract did not even mention the ErbB pathway",""
+"ErbB signaling pathway","Notch signaling pathway","Notch AND ErbB AND pathway","24970336 ","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not even mention the ErbB pathway",""
+"Thyroid hormone synthesis","ErbB signaling pathway","Thyroid hormone synthesis AND ErbB AND crosstalk","19269830 ","no","no","","","","","","","","","","","","","The full text was not read because the abstract indicates that the two do not crosstalk",""
+"ErbB signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND ErbB AND crosstalk","19269830 ","no","no","","","","","","","","","","","","","The full text was not read because the abstract indicates that the two do not crosstalk",""
+"Thyroid hormone synthesis","ErbB signaling pathway","Thyroid hormone synthesis AND ErbB AND pathway","10938135","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not give any indication of crosstalk",""
+"ErbB signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND ErbB AND pathway","10938135","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not give any indication of crosstalk",""
+"Thyroid hormone synthesis","ErbB signaling pathway","Thyroid hormone synthesis AND ErbB AND pathway","14523990","no","no","","","","","","","","","","","","","The full text was not read because the thyroid hormone synthesis pathway was not mentioned in the abstract",""
+"ErbB signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND ErbB AND pathway","14523990","no","no","","","","","","","","","","","","","The full text was not read because the thyroid hormone synthesis pathway was not mentioned in the abstract",""
+"Thyroid hormone synthesis","ErbB signaling pathway","Thyroid hormone synthesis AND ErbB AND pathway","16125352 ","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention thyroid hormone synthesis",""
+"ErbB signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND ErbB AND pathway","16125352 ","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention thyroid hormone synthesis",""
+"Thyroid hormone synthesis","ErbB signaling pathway","Thyroid hormone synthesis AND ErbB AND pathway","16125352 ","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses interactions between estrogen and ErbB",""
+"ErbB signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND ErbB AND pathway","16125352 ","no","no","","","","","","","","","","","","","The full article was not read because the abstract only discusses interactions between estrogen and ErbB",""
+"Thyroid hormone synthesis","Estrogen signaling pathway","Thyroid hormone synthesis AND Estrogen AND crosstalk","24685768 ","no","no","","","","","","","","","","","","","The article discusses possible crosstalk between the two pathways, but ultimately does not give any definitive details except an indirect way in which thyroid hormone synthesis affects estrogen receptor.","For example, TH can regulate ER action via a membrane TH receptor and MAPK pathway in breast cancer cells"
+"Estrogen signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Estrogen AND crosstalk","24685768 ","no","no","","","","","","","","","","","","","The article discusses possible crosstalk between the two pathways, but ultimately does not give any definitive details except an indirect way in which thyroid hormone synthesis affects estrogen receptor.","For example, TH can regulate ER action via a membrane TH receptor and MAPK pathway in breast cancer cells"
+"Thyroid hormone synthesis","Estrogen signaling pathway","Thyroid hormone synthesis AND Estrogen AND crosstalk","22132110 ","no","no","","","","","","","","","","","","","The article describes a relationship between thyroid hormone and ER, but only describes an indirect relationship and not any direct interactions","We demonstrate by confocal microscopy in Fig. 4B that thyroid hormone causes nuclear accumulation of phosphorylated ERα in non-small cell NCI-H522 lung cancer cells"
+"Estrogen signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Estrogen AND crosstalk","22132110 ","no","no","","","","","","","","","","","","","The article describes a relationship between thyroid hormone and ER, but only describes an indirect relationship and not any direct interactions","We demonstrate by confocal microscopy in Fig. 4B that thyroid hormone causes nuclear accumulation of phosphorylated ERα in non-small cell NCI-H522 lung cancer cells."
+"Thyroid hormone synthesis","Estrogen signaling pathway","Thyroid hormone synthesis AND Estrogen AND crosstalk","20626568","yes","yes","activating","T3","hormone","hormone","ER-alpha","Other","Other","Rana pipiens","brain","BTO:0000142","Development","Previous research in our laboratory has shown that T3 regulates the expression of the oestrogen-responsive genes: oestrogen receptor alpha (eralpha) and cyp19 in the brain of Lithobates (Rana) pipiens","The crosstalk in this article is very vague but states many times that the presence of T3 has some effect on the levels/activity of ER-alpha",""
+"Estrogen signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Estrogen AND crosstalk","20626568 ","no","no","","","","","","","","","","","","","There was only evidence of crosstalk from thyroid hormone synthesis to estrogen.",""
+"Thyroid hormone synthesis","Estrogen signaling pathway","Thyroid hormone synthesis AND Estrogen AND crosstalk","15778291","no","no","","","","","","","","","","","","","The paper suggests crosstalk between the two pathways, but only through indirect mechanisms.","T3 (10-7 M), via TRα1 (Fig. 1A) or TRβ1 (Fig. 1B), potentiated ERα-mediated transcription from a consensus ERE-driven luciferase gene compared with a single 17β-estradiol pulse, similar to the potentiation caused by E-BSA and 17β-estradiol added in the first pulse."
+"Estrogen signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Estrogen AND crosstalk","15778291","no","no","","","","","","","","","","","","","The paper suggests crosstalk between the two pathways, but only through indirect mechanisms.","T3 (10-7 M), via TRα1 (Fig. 1A) or TRβ1 (Fig. 1B), potentiated ERα-mediated transcription from a consensus ERE-driven luciferase gene compared with a single 17β-estradiol pulse, similar to the potentiation caused by E-BSA and 17β-estradiol added in the first pulse. "
+"Thyroid hormone synthesis","Estrogen signaling pathway","Thyroid hormone synthesis AND Estrogen AND crosstalk","26109800","no","no","","","","","","","","","","","","","The full text was not read because the article only states that each pathway has an effect on calcium, but not on each other.",""
+"Estrogen signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Estrogen AND crosstalk","26109800","no","no","","","","","","","","","","","","","The full text was not read because the article only states that each pathway has an effect on calcium, but not on each other.",""
+"Thyroid hormone synthesis","Estrogen signaling pathway","Thyroid hormone synthesis AND Estrogen AND crosstalk","25056680 ","no","no","","","","","","","","","","","","","The full article was not read because the abstract only briefly mentions each pathway and does not give any indication that they interact",""
+"Estrogen signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Estrogen AND crosstalk","25056680 ","no","no","","","","","","","","","","","","","The full article was not read because the abstract only briefly mentions each pathway and does not give any indication that they interact",""
+"Thyroid hormone synthesis","Estrogen signaling pathway","Thyroid hormone synthesis AND Estrogen AND crosstalk","25056680","yes","yes","","TH","hormone","hormone","esr1","P50241","UNIPROT","Oryzias latipes","brain","BTO:0000142","Development","Cross-regulation between TH and ER has also been observed in the tadpole brain (Rana pipiens (Hogan et al., 2007), and TH increased ERα mRNA in GH3 cells, thereby potentiating the actions of estrogen ","There is a lot of suggestion of crosstalk in the article, but only transcriptional crosstalk is described clearly.",""
+"Estrogen signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Estrogen AND crosstalk","25056680 ","no","no","","","","","","","","","","","","","Crosstalk was only described in the other direction.",""
+"Melanogenesis","Insulin signaling pathway","Melanogenesis AND Insulin AND pathway","26646901","no","","","","","","","","","","","","","","epigenomics study",""
+"Insulin signaling pathway","Melanogenesis","Melanogenesis AND Insulin AND pathway","26646901","no","","","","","","","","","","","","","","epigenomics paper",""
+"MAPK signaling pathway","Melanogenesis","MAPK AND Melanogenesis AND pathway","26586997","yes","unknown","inhibiting","","","","","","","","","","","Taken together, the suppressive effects of QCGG on melanogenesis may involve down-regulation of MITF and its downstream signaling pathway via phosphorylation of p38 MAPK and CREB along with reduced cAMP levels.","",""
+"Melanogenesis","MAPK signaling pathway","MAPK AND Melanogenesis AND pathway","26586997","no","","","","","","","","","","","","","","",""
+"Melanogenesis","MAPK signaling pathway","MAPK AND Melanogenesis AND pathway","24743745","no","","","","","","","","","","","","","","","The results demonstrated that AM-EO suppresses melanin production by decreasing tyrosinase activity through the regulation of the JNK and ERK signaling pathways."
+"MAPK signaling pathway","Melanogenesis","MAPK AND Melanogenesis AND pathway","24743745","no","","","","","","","","","","","","","","","The results demonstrated that AM-EO suppresses melanin production by decreasing tyrosinase activity through the regulation of the JNK and ERK signaling pathways."
+"Melanogenesis","MAPK signaling pathway","MAPK AND Melanogenesis AND pathway","15760340","no","","","","","","","","","","","","","","PTLF not part of melanogenesis pathway","The results suggest that the activation of p38 MAPK plays a crucial role in PTLF-induced B16F10 melanogenesis by up-regulating tyrosinase expression."
+"MAPK signaling pathway","Melanogenesis","MAPK AND Melanogenesis AND pathway","15760340","no","","","","","","","","","","","","","","","The results suggest that the activation of p38 MAPK plays a crucial role in PTLF-induced B16F10 melanogenesis by up-regulating tyrosinase expression."
+"Melanogenesis","Toll-like receptor signaling pathway","Melanogenesis AND Toll-like receptor AND pathway","26232912","no","","","","","","","","","","","","","","","Furthermore, we found that the signal transduction, melanogenesis, and toll-like receptor signaling pathways might be involved in oxaliplatin-resistant colon cancer."
+"Toll-like receptor signaling pathway","Melanogenesis","Melanogenesis AND Toll-like receptor AND pathway","26232912","no","","","","","","","","","","","","","","","Furthermore, we found that the signal transduction, melanogenesis, and toll-like receptor signaling pathways might be involved in oxaliplatin-resistant colon cancer."
+"Thyroid hormone synthesis","Estrogen signaling pathway","Thyroid hormone synthesis AND Estrogen AND crosstalk","15257551","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only talked about crosstalk between estrogen and wnt",""
+"Estrogen signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Estrogen AND crosstalk","15257551","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only talked about crosstalk between estrogen and wnt",""
+"Thyroid hormone synthesis","Estrogen signaling pathway","Thyroid hormone synthesis AND Estrogen AND crosstalk","16516516","no","no","","","","","","","","","","","","","The paper only discusses the interactions between actual thyroid hormone and estrogen, not the thyroid hormone synthesis pathway",""
+"Estrogen signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Estrogen AND crosstalk","16516516","no","no","","","","","","","","","","","","","The paper only discusses the interactions between actual thyroid hormone and estrogen, not the thyroid hormone synthesis pathway",""
+"Thyroid hormone synthesis","Estrogen signaling pathway","Thyroid hormone synthesis AND Estrogen AND crosstalk","22265959","no","no","","","","","","","","","","","","","The full paper paper was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Estrogen signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Estrogen AND crosstalk","22265959","no","no","","","","","","","","","","","","","The full paper paper was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Estrogen signaling pathway","Thyroid hormone synthesis AND Estrogen AND crosstalk","19269830","no","no","","","","","","","","","","","","","The abstract suggests potential crosstalk, but there are only indirect relationships described in the text.",""
+"Estrogen signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Estrogen AND crosstalk","19269830","no","no","","","","","","","","","","","","","The abstract suggests potential crosstalk, but there are only indirect relationships described in the text.",""
+"Thyroid hormone synthesis","Estrogen signaling pathway","Thyroid hormone synthesis AND Estrogen AND crosstalk","9644246","no","no","","","","","","","","","","","","","The full paper was not read because there was no mention of thyroid hormone synthesis in the abstract",""
+"Estrogen signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Estrogen AND crosstalk","9644246","no","no","","","","","","","","","","","","","The full paper was not read because there was no mention of thyroid hormone synthesis in the abstract",""
+"Thyroid hormone synthesis","GnRH signaling pathway","Thyroid hormone synthesis AND GnRH AND crosstalk ","25108122","unclear","yes","activating","T4","hormone","hormone","GnRH2/GnRH3","I2B313/I2B314","UNIPROT","Gobiocypris rarus","liver","BTO:0000759","treatment with herbicide","One possible explanation for the regulation between the HPT and HPG axes could be that the increase of T4 initiates the transcription of gnrh through the feed-back mechanism, which leads to alternation of sex hormone metabolism","The paper suggests transcriptional crosstalk, but only uses it as a possible explanation and not a fact, so the crosstalk is not for sure.",""
+"Thyroid hormone synthesis","GnRH signaling pathway","Thyroid hormone synthesis AND GnRH AND crosstalk ","25108122","unclear","yes","activating","T4","hormone","hormone","GnRH2/GnRH3","I2B313/I2B314","UNIPROT","Gobiocypris rarus","ovary","BTO:0000975","treatment with herbicide","One possible explanation for the regulation between the HPT and HPG axes could be that the increase of T4 initiates the transcription of gnrh through the feed-back mechanism, which leads to alternation of sex hormone metabolism","The paper suggests transcriptional crosstalk, but only uses it as a possible explanation and not a fact, so the crosstalk is not for sure.",""
+"GnRH signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND GnRH AND crosstalk","25108122","no","no","","","","","","","","","","","","","The paper only suggested crosstalk from thyroid hormone synthesis to GnRH, not the other way around",""
+"Thyroid hormone synthesis","GnRH signaling pathway","Thyroid hormone synthesis AND GnRH AND pathway ","21641659","no","no","","","","","","","","","","","","","The abstract suggests possible crosstalk, but it is not mentioned in the paper",""
+"GnRH signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND GnRH AND pathway","21641659","no","no","","","","","","","","","","","","","The abstract suggests possible crosstalk, but it is not mentioned in the paper",""
+"Thyroid hormone synthesis","GnRH signaling pathway","Thyroid hormone synthesis AND GnRH AND pathway","22719854","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not mention both pathways in the same context",""
+"GnRH signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND GnRH AND pathway","22719854","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not mention both pathways in the same context",""
+"Thyroid hormone synthesis","GnRH signaling pathway","Thyroid hormone synthesis AND GnRH AND pathway","10803569","no","no","","","","","","","","","","","","","The paper mainly discusses that T3 does not affect GnRH mRNA levels",""
+"GnRH signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND GnRH AND pathway","10803569","no","no","","","","","","","","","","","","","The paper mainly discusses that T3 does not affect GnRH mRNA levels",""
+"Thyroid hormone synthesis","GnRH signaling pathway","Thyroid hormone synthesis AND GnRH AND pathway","22357547","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses both pathways interacting with FOXP3, not each other",""
+"GnRH signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND GnRH AND pathway","22357547","no","no","","","","","","","","","","","","","The full text was not read because the abstract only discusses both pathways interacting with FOXP3, not each other",""
+"Thyroid hormone synthesis","GnRH signaling pathway","Thyroid hormone synthesis AND GnRH AND pathway","22504272","no","no","","","","","","","","","","","","","The full article was not read because there was no mention of GnRH in the abstract",""
+"GnRH signaling pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND GnRH AND pathway","22504272","no","no","","","","","","","","","","","","","The full article was not read because there was no mention of GnRH in the abstract",""
+"Adipocytokine signaling pathway","Apoptosis","Adipocytokine AND Apoptosis AND pathway","26857566","unclear","no","unknown","Nampt","Q80Z29","UNIPROT","","","","Rattus norvegicus","lymph node","BTO:0000784","LPS-induced apoptosis","Visfatin had a pro-apoptotic effect on normal MLNs, whereas it exerted an anti-apoptotic effect during LPS-induced cell apoptosis in rat MLNs.","Visfatin has regulatory role; without LPS crosstalk is positive, and with LPS crosstalk is negative",""
+"Apoptosis","Adipocytokine signaling pathway","Adipocytokine AND Apoptosis AND pathway","26857566","no","","","","","","","","","","","","","","other direction",""
+"Apoptosis","Adipocytokine signaling pathway","Adipocytokine AND Apoptosis AND pathway","26808997","no","","","","","","","","","Gallus gallus","cardiac muscle fiber","BTO:0002320","H2O2 treatment","","found differential expression in several pathways including Adipocytokine, but no evidence of crosstalk","Many other differentially expressed genes were associated with metabolic pathways (including 'Fatty acid metabolism', 'Alanine, aspartate, and glutamate metabolism', and 'Biosynthesis of unsaturated fatty acids') and cell signaling pathways (including 'PPAR signaling pathway', 'Adipocytokine signaling pathway', 'TGF-beta signaling pathway', 'MAPK signaling pathway', and 'p53 signaling pathway')"
+"Adipocytokine signaling pathway","Apoptosis","Adipocytokine AND Apoptosis AND pathway","26808997","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","Apoptosis","Adipocytokine AND Apoptosis AND pathway","23135225","yes","unknown","inhibiting","SERPINA12","Q8IW75","UNIPROT","MAPK3/MAPK1","P27361/P28482","UNIPROT","Homo sapiens","osteoblast","BTO:0001593","serum deprivation","Western blot analysis revealed that vaspin upregulates the expression of Bcl-2 and downregulates that of Bax in a dose-dependent manner. ","",""
+"Apoptosis","Adipocytokine signaling pathway","Adipocytokine AND Apoptosis AND pathway","23135225","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","Apoptosis","Adipocytokine AND Apoptosis AND pathway","21803433","no","","","","","","","","","","","","","","",""
+"Apoptosis","Adipocytokine signaling pathway","Adipocytokine AND Apoptosis AND pathway","21803433","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","Toll-like receptor signaling pathway","Adipocytokine AND Apoptosis AND pathway","23674516","yes","yes","inhibiting","Adipoq","Q60994","UNIPROT","Tlr4","Q9QUK6","UNIPROT","Mus musculus","cardiac muscle fiber","BTO:0002320","myocarditis","Our observations indicate that APN protects against inflammation and injury in autoimmune myocarditis by diminishing TLR4 signalling thereby attenuating inflammatory activation and interaction of cardiac and immune cells.","",""
+"Toll-like receptor signaling pathway","Adipocytokine signaling pathway","Adipocytokine AND Apoptosis AND pathway","23674516","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","Apoptosis","Adipocytokine AND Apoptosis AND pathway","21471274","yes","unknown","inhibiting","Nampt","Q99KQ4","UNIPROT","","","","Mus musculus","pancreatic beta cell","BTO:0000783","palmitate-induced apoptosis","Visfatin significantly reduced the cell apoptosis induced by palmitate and caused a significant change in the expression of several proapoptotic proteins, including upregulation of Bcl-2 and a marked downregulation of cytochrome c and caspase 3.","not sure what protein B should be",""
+"Apoptosis","Adipocytokine signaling pathway","Adipocytokine AND Apoptosis AND pathway","21471274","no","","","","","","","","","","","","","","",""
+"Apoptosis","ErbB signaling pathway","Apoptosis AND ErbB AND crosstalk","25515931","no","","","","","","","","","","","","","","HUNK not part of apoptosis pathway.",""
+"ErbB signaling pathway","Apoptosis","Apoptosis AND ErbB AND crosstalk","25515931","no","","","","","","","","","","","","","","HUNK not part of apoptosis pathway.",""
+"ErbB signaling pathway","Apoptosis","Apoptosis AND ErbB AND crosstalk","24866893","no","","","","","","","","","","","","","","",""
+"Apoptosis","ErbB signaling pathway","Apoptosis AND ErbB AND crosstalk","24866893","no","","","","","","","","","","","","","","",""
+"Apoptosis","ErbB signaling pathway","Apoptosis AND ErbB AND crosstalk","22791816","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Apoptosis","Apoptosis AND ErbB AND crosstalk","22791816","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Apoptosis","Apoptosis AND ErbB AND crosstalk","10490835","no","","","","","","","","","","","","","","",""
+"Apoptosis","ErbB signaling pathway","Apoptosis AND ErbB AND crosstalk","10490835","no","","","","","","","","","","","","","","",""
+"Apoptosis","ErbB signaling pathway","Apoptosis AND ErbB AND crosstalk","12943694","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Apoptosis","Apoptosis AND ErbB AND crosstalk","12943694","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Apoptosis","Apoptosis AND ErbB AND crosstalk","21854628","no","","","","","","","","","","","","","","",""
+"Apoptosis","ErbB signaling pathway","Apoptosis AND ErbB AND crosstalk","21854628","no","","","","","","","","","","","","","","",""
+"Apoptosis","ErbB signaling pathway","Apoptosis AND ErbB AND crosstalk","16096368","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Apoptosis","Apoptosis AND ErbB AND crosstalk","16096368","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Apoptosis","Apoptosis AND ErbB AND crosstalk","16609042","no","","unknown","","","","","","","Homo sapiens","MCF-7 cell","BTO:0000093","cancer; raloxifene treatment","","","Consequently, trastuzumab decreased prosurvival/proliferative proteins: phospho-HER2/neu, total HER2/neu, phospho-Akt (protein kinase B), glycogen synthetase kinase-3, cyclin D1, and the antiapoptotic protein X chromosome-linked inhibitor of apoptosis, whereas increasing the proapoptotic protein, caspase-7, in raloxifene-treated MCF-7RALT tumors"
+"Apoptosis","ErbB signaling pathway","Apoptosis AND ErbB AND crosstalk","16609042","no","","","","","","","","","","","","","","",""
+"Apoptosis","ErbB signaling pathway","Apoptosis AND ErbB AND crosstalk","18501066","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Apoptosis","Apoptosis AND ErbB AND crosstalk","18501066","no","","","","","","","","","","","","","","",""
+"Adherens junction","Jak-STAT signaling pathway","Adherens AND Jak-STAT AND pathway","25375180","no","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","Adherens junction","Adherens AND Jak-STAT AND pathway","25375180","no","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","Adherens junction","Adherens AND Jak-STAT AND pathway","18370048","no","","","","","","","","","","","","","","",""
+"Adherens junction","Jak-STAT signaling pathway","Adherens AND Jak-STAT AND pathway","18370048","no","","","","","","","","","","","","","","",""
+"Melanogenesis","mTOR signaling pathway","Melanogenesis AND mTOR AND pathway ","26901194","no","no","","","","","","","","","","","","","The paper only indicates interactions in the other direction.",""
+"mTOR signaling pathway","Melanogenesis","Melanogenesis AND mTOR AND pathway","26901194","yes","yes","unknown","Akt1","P31750","UNIPROT","Mitf","Q08874","UNIPROT","Mus musculus","melanoma cell","BTO:0000848","cancer","Hinokitiol decreased MITF and tyrosinase expression in B16F10 cells through reducing AKT phosphorylation.","The paper does not suggest any direct interaction between the pathways, but it does state that a phosphorylation event of AKT causes a decrease in the expression of proteins in the melanogenesis pathway. It is not clear whether the phosphorylation is activating or deactivating.",""
+"ErbB signaling pathway","mTOR signaling pathway","ErbB AND mTOR AND crosstalk ","24866893","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not give any indication of crosstalk between the two pathways",""
+"mTOR signaling pathway","ErbB signaling pathway","ErbB AND mTOR AND crosstalk","24866893","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not give any indication of crosstalk between the two pathways",""
+"ErbB signaling pathway","mTOR signaling pathway","ErbB AND mTOR AND crosstalk","25530422","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention any potential interactions between the pathways.",""
+"mTOR signaling pathway","ErbB signaling pathway","ErbB AND mTOR AND crosstalk","25530422","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention any potential interactions between the pathways.",""
+"ErbB signaling pathway","mTOR signaling pathway","ErbB AND mTOR AND crosstalk","22686613","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest crosstalk between the two pathways.",""
+"mTOR signaling pathway","ErbB signaling pathway","ErbB AND mTOR AND crosstalk","22686613","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest crosstalk between the two pathways.",""
+"ErbB signaling pathway","mTOR signaling pathway","ErbB AND mTOR AND crosstalk","18807177","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not suggest any crosstalk between the two pathways",""
+"mTOR signaling pathway","ErbB signaling pathway","ErbB AND mTOR AND crosstalk","18807177","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not suggest any crosstalk between the two pathways",""
+"ErbB signaling pathway","mTOR signaling pathway","ErbB AND mTOR AND crosstalk","15163844","no","no","","","","","","","","","","","","","The full text was not read because there was suggestion in the abstract for crosstalk between the two pathways.",""
+"mTOR signaling pathway","ErbB signaling pathway","ErbB AND mTOR AND crosstalk","15163844","no","no","","","","","","","","","","","","","The full text was not read because there was suggestion in the abstract for crosstalk between the two pathways.",""
+"Adherens junction","MAPK signaling pathway","MAPK AND Adherens Junction AND pathway","25173696","no","","","","","","","","","","","","","","microfilament remodeling; more tight junction than AJ",""
+"MAPK signaling pathway","Adherens junction","MAPK AND Adherens Junction AND pathway","25173696","no","","","","","","","","","","","","","","more tight junction than AJ",""
+"MAPK signaling pathway","Adherens junction","MAPK AND Adherens Junction AND pathway","23593143","no","","","","","","","","","","","","","","",""
+"Adherens junction","MAPK signaling pathway","MAPK AND Adherens Junction AND pathway","23593143","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Adherens junction","MAPK AND Adherens Junction AND pathway","24899161","yes","no","activating","R","P08645","UNIPROT","shg","Q24298","UNIPROT","Drosophila melanogaster","epithelial cell","BTO:0000414","","Rap1 activity is now well recognized for its role in cadherin-based cell–cell adhesion, and various Rap1 pathway components, including Rap1 itself, have been found to localize to adherens junctions (Knox and Brown 2002) ","cites 11847339 as evidence, but this paper does not show up in pubmed search",""
+"Adherens junction","MAPK signaling pathway","MAPK AND Adherens Junction AND pathway","24899161","no","","","","","","","","","","","","","","other direction",""
+"MAPK signaling pathway","Adherens junction","MAPK AND Adherens Junction AND pathway","22665525","no","","","","","","","","","","","","","","differential regulation of adherens proteins upon MAPK perturbation but evidence purely inferential ",""
+"Adherens junction","MAPK signaling pathway","MAPK AND Adherens Junction AND pathway","22665525","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Adherens junction","MAPK AND Adherens Junction AND pathway","24373847","no","","","","","","","","","","","","","","",""
+"Adherens junction","MAPK signaling pathway","MAPK AND Adherens Junction AND pathway","24373847","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Adherens junction","MAPK AND Adherens Junction AND pathway","24373847","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Adherens junction","MAPK AND Adherens Junction AND pathway","21925492","no","","","","","","","","","","","","","","",""
+"Adherens junction","MAPK signaling pathway","MAPK AND Adherens Junction AND pathway","21925492","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Adherens junction","MAPK AND Adherens Junction AND pathway","21925492","no","","","","","","","","","","","","","","",""
+"Adherens junction","MAPK signaling pathway","MAPK AND Adherens Junction AND pathway","25174387","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Adherens junction","MAPK AND Adherens Junction AND pathway","25174387","no","","","","","","","","","","","","","","",""
+"Adherens junction","MAPK signaling pathway","MAPK AND Adherens Junction AND pathway","25482622","no","","","","","","","","","","","","","","review; discusses eph signaling which signals to MAPK, but not necessarily part of MAPK pathway",""
+"MAPK signaling pathway","Adherens junction","MAPK AND Adherens Junction AND pathway","25482622","no","","","","","","","","","","","","","","",""
+"Adherens junction","MAPK signaling pathway","MAPK AND Adherens Junction AND pathway","19931545","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Adherens junction","MAPK AND Adherens Junction AND pathway","19931545","no","","","","","","","","","","","","","","",""
+"Adherens junction","MAPK signaling pathway","MAPK AND Adherens Junction AND pathway","16159815","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Adherens junction","MAPK AND Adherens Junction AND pathway","16159815","unclear","yes","inhibiting","MAPK14","F1RYA1","UNIPROT","CDH5","O02840","UNIPROT","Sus scrofa","myocardium","BTO:0000901","Ischemia","Aprotinin preserves adherens junctions after regional ischemia and cardioplegic arrest through a mechanism potentially involving the p38 MAPK pathway, resulting in preservation of the VE barrier and reduced myocardial tissue edema.","not strong evidence; inferential",""
+"ErbB signaling pathway","mTOR signaling pathway","ErbB AND mTOR AND crosstalk ","22922893","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the pathways interacting with a different pathway.",""
+"mTOR signaling pathway","ErbB signaling pathway","ErbB AND mTOR AND crosstalk","22922893","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the pathways interacting with a different pathway.",""
+"Estrogen signaling pathway","mTOR signaling pathway","Estrogen AND mTOR AND crosstalk","25530422","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the two pathways interacting with something else and not each other.",""
+"mTOR signaling pathway","Estrogen signaling pathway","Estrogen AND mTOR AND crosstalk","25530422","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the two pathways interacting with something else and not each other.",""
+"Estrogen signaling pathway","mTOR signaling pathway","Estrogen AND mTOR AND crosstalk","24866893","no","no","","","","","","","","","","","","","The abstract only mentions estrogen with respect to the type of breast cancer cell, and does not indicate that it interacts with mTOR.",""
+"mTOR signaling pathway","Estrogen signaling pathway","Estrogen AND mTOR AND crosstalk","24866893","no","no","","","","","","","","","","","","","The abstract only mentions estrogen with respect to the type of breast cancer cell, and does not indicate that it interacts with mTOR.",""
+"Estrogen signaling pathway","mTOR signaling pathway","Estrogen AND mTOR AND crosstalk","24861776","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the pathways interacting with other things and not each other.",""
+"mTOR signaling pathway","Estrogen signaling pathway","Estrogen AND mTOR AND crosstalk","24861776","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the pathways interacting with other things and not each other.",""
+"Estrogen signaling pathway","mTOR signaling pathway","Estrogen AND mTOR AND crosstalk","24011769","no","no","","","","","","","","","","","","","The full text was not read because the paper only mentioned estrogen with respect to the type of breast cancer cell.",""
+"Adherens junction","MAPK signaling pathway","Adherens AND MAPK AND pathway","18245854","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Adherens junction","Adherens AND MAPK AND pathway","18245854","no","","","","","","","","","","","","","","",""
+"mTOR signaling pathway","Estrogen signaling pathway","Estrogen AND mTOR AND crosstalk","24011769","no","no","","","","","","","","","","","","","The full text was not read because the paper only mentioned estrogen with respect to the type of breast cancer cell.",""
+"Estrogen signaling pathway","mTOR signaling pathway","Estrogen AND mTOR AND crosstalk","18807177","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned an indirect relationship between the pathways.",""
+"mTOR signaling pathway","Estrogen signaling pathway","Estrogen AND mTOR AND crosstalk","18807177","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned an indirect relationship between the pathways.",""
+"HIF-1 signaling pathway","mTOR signaling pathway","HIF-1 AND mTOR AND pathway ","25418470","no","no","","","","","","","","","","","","","The paper suggests crosstalk, but does not actually reveal any direct interactions.","Using pharmacological inhibitors we also demonstrated a crucial role for the phosphatidylinositol-3 kinase (PI-3K)/mammalian target of rapamycin (mTOR) pathway in IL-1β-induced HIF-1α accumulation in MCF-7 cells."
+"mTOR signaling pathway","HIF-1 signaling pathway","HIF-1 AND mTOR AND pathway","25418470","no","no","","","","","","","","","","","","","The paper suggests crosstalk, but does not actually reveal any direct interactions.","Using pharmacological inhibitors we also demonstrated a crucial role for the phosphatidylinositol-3 kinase (PI-3K)/mammalian target of rapamycin (mTOR) pathway in IL-1β-induced HIF-1α accumulation in MCF-7 cells."
+"HIF-1 signaling pathway","mTOR signaling pathway","HIF-1 AND mTOR AND pathway","25483439","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only says that the two pathways are affected by a different protein.",""
+"mTOR signaling pathway","HIF-1 signaling pathway","HIF-1 AND mTOR AND pathway","25483439","","","","","","","","","","","","","","","The full paper was not read because the abstract only says that the two pathways are affected by a different protein.",""
+"HIF-1 signaling pathway","mTOR signaling pathway","HIF-1 AND mTOR AND pathway","25448705","no","no","unknown","","","","","","","","","","","","There only seems to be crosstalk from mTOR to HIF-1",""
+"mTOR signaling pathway","HIF-1 signaling pathway","HIF-1 AND mTOR AND pathway","25448705","yes","no","activating","MTOR","P42345","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","macrophage","BTO:0000801","normal","Rapamycin treatment suppressed the expression of HIF-1α and HIF-2α","Since rapamycin is an inhibitor of mTOR, the suppression of HIF-1 by rapamycin means that the two pathways are positively connected",""
+"HIF-1 signaling pathway","mTOR signaling pathway","HIF-1 AND mTOR AND pathway","23297826","","","","","","","","","","","","","","","Paper has been requested",""
+"mTOR signaling pathway","HIF-1 signaling pathway","HIF-1 AND mTOR AND pathway","23297826","","","","","","","","","","","","","","","Paper has been requested",""
+"HIF-1 signaling pathway","mTOR signaling pathway","HIF-1 AND mTOR AND pathway","25075425","","","","","","","","","","","","","","","Paper has been requested",""
+"mTOR signaling pathway","HIF-1 signaling pathway","HIF-1 AND mTOR AND pathway","25075425","","","","","","","","","","","","","","","Paper has been requested",""
+"Insulin signaling pathway","mTOR signaling pathway","Insulin AND mTOR AND crosstalk ","25866088","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not give any indication that the two pathways connected.",""
+"mTOR signaling pathway","Insulin signaling pathway","Insulin AND mTOR AND crosstalk","25866088","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not give any indication that the two pathways connected.",""
+"Adherens junction","MAPK signaling pathway","Adherens AND MAPK AND pathway","10969083","yes","no","activating","CDH1","P12830","UNIPROT","EGFR","P00533","UNIPROT","Homo sapiens","HaCaT cell","BTO:0000552","non-tumorigenic immortalized","Furthermore, we found that E-cadherins stimulate the MAPK pathway through the ligand-independent activation of epidermal growth factor receptors and the consequent activation of a biochemical route leading to the stimulation of MAPKs.","",""
+"MAPK signaling pathway","Adherens junction","Adherens AND MAPK AND pathway","10969083","no","","","","","","","","","","","","","","",""
+"Adherens junction","Neurotrophin signaling pathway","Adherens AND Neurotrophin AND pathway","25222135","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Adherens junction","Adherens AND Neurotrophin AND pathway","25222135","no","","","","","","","","","","","","","","",""
+"Adherens junction","Neurotrophin signaling pathway","Adherens AND Neurotrophin AND pathway","24365204","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Adherens junction","Adherens AND Neurotrophin AND pathway","24365204","no","","","","","","","","","","","","","","",""
+"Adherens junction","Neurotrophin signaling pathway","Adherens AND Neurotrophin AND pathway","22895821","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Adherens junction","Adherens AND Neurotrophin AND pathway","22895821","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","mTOR signaling pathway","Insulin AND mTOR AND crosstalk","25971373","yes","no","activating","Insulin","hormone","hormone","RPS6KB1","P23443","UNIPROT","Homo sapiens","skeletal muscle cell","BTO:0004392","mechanical stress","Moreover, the addition of leucine and insulin increased the phosphorylation of p70S6K without dephosphorylation of AMPKα.","Crosstalk was only shown in this direction.",""
+"mTOR signaling pathway","Insulin signaling pathway","Insulin AND mTOR AND crosstalk","25971373","no","no","","","","","","","","","","","","","Crosstalk was only found in the other direction.",""
+"Insulin signaling pathway","mTOR signaling pathway","Insulin AND mTOR AND crosstalk","22896210","no","no","","","","","","","","","","","","","The paper suggested crosstalk, but did not provide any real evidence.","These diet-induced changes in IGF-1R and EGFR activation subsequently altered downstream signaling to Akt and mTOR (and other signaling pathways), "
+"mTOR signaling pathway","Insulin signaling pathway","Insulin AND mTOR AND crosstalk","22896210","no","no","","","","","","","","","","","","","The paper suggested crosstalk, but did not provide any real evidence.","These diet-induced changes in IGF-1R and EGFR activation subsequently altered downstream signaling to Akt and mTOR (and other signaling pathways), "
+"Insulin signaling pathway","mTOR signaling pathway","Insulin AND mTOR AND crosstalk ","20388847","no","no","","","","","","","","","","","","","The paper only seemed to suggest crosstalk in the other direction.",""
+"mTOR signaling pathway","Insulin signaling pathway","Insulin AND mTOR AND crosstalk","20388847","unclear","no","","","","","","","","","","","","","The paper suggest crosstalk, but all the interaction mentioned are part of the actual insulin pathway, so it is hard to tell if there is actually crosstalk","These results indicate that the PI3K/Akt/mTORC1 pathway mediates a novel crosstalk between insulin receptor and GPCR signaling systems."
+"Insulin signaling pathway","mTOR signaling pathway","Insulin AND mTOR AND crosstalk","22980812","unclear","","","","","","","","","","","","","","Since mTOR is part of the insulin pathway, it is hard to determine if there is crosstalk",""
+"mTOR signaling pathway","Insulin signaling pathway","Insulin AND mTOR AND crosstalk","22980812","unclear","","","","","","","","","","","","","","Since mTOR is part of the insulin pathway, it is hard to determine if there is crosstalk",""
+"Hedgehog signaling pathway","Insulin secretion pathway","Hedgehog AND Insulin secretion AND pathway ","21969560","no","no","","","","","","","","","","","","","The full paper was not read because insulin secretion was not mentioned in the abstract.",""
+"Insulin secretion pathway","Hedgehog signaling pathway","Hedgehog AND Insulin secretion AND pathway","21969560","no","no","","","","","","","","","","","","","The full paper was not read because insulin secretion was not mentioned in the abstract.",""
+"Hedgehog signaling pathway","Insulin secretion pathway","Hedgehog AND Insulin secretion AND pathway","16024793","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not indicate any potential interactions.",""
+"Insulin secretion pathway","Hedgehog signaling pathway","Hedgehog AND Insulin secretion AND pathway","16024793","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not indicate any potential interactions.",""
+"Insulin secretion pathway","Notch signaling pathway","Insulin secretion AND Notch AND pathway ","25371201","no","no","unknown","","","","","","","","","","","","Crosstalk was only seen in one direction",""
+"Notch signaling pathway","Insulin secretion pathway","Insulin secretion AND Notch AND pathway","25371201","yes","yes","activating","HES3","Q5TGS1","UNIPROT","","","","Homo sapiens","pancreatic islet","BTO:0000991","normal","Hes3 RNA interference reduced evoked insulin release.","The paper only shows that a protein expressed because of notch causes an increase in the release of insulin.",""
+"Insulin secretion pathway","Notch signaling pathway","Insulin secretion AND Notch AND pathway","26566963","no","no","","","","","","","","","","","","","The abstract only suggested possible crosstalk with insulin, not insulin secretion.",""
+"Notch signaling pathway","Insulin secretion pathway","Insulin secretion AND Notch AND pathway","26566963","no","no","","","","","","","","","","","","","The abstract only suggested possible crosstalk with insulin, not insulin secretion.",""
+"Insulin secretion pathway","Notch signaling pathway","Insulin secretion AND Notch AND pathway","22849859","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not suggest any crosstalk",""
+"Notch signaling pathway","Insulin secretion pathway","Insulin secretion AND Notch AND pathway","22849859","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not suggest any crosstalk",""
+"Insulin secretion pathway","Notch signaling pathway","Insulin secretion AND Notch AND pathway","21208992","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk.",""
+"Notch signaling pathway","Insulin secretion pathway","Insulin secretion AND Notch AND pathway","21208992","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk.",""
+"Insulin secretion pathway","Notch signaling pathway","Insulin secretion AND Notch AND pathway","17922104","no","no","","","","","","","","","","","","","The paper did not discuss any crosstalk.",""
+"Notch signaling pathway","Insulin secretion pathway","Insulin secretion AND Notch AND pathway","17922104","no","no","","","","","","","","","","","","","The text suggested some kind of effect on insulin secretion by notch, but it was not discussed in detail.","The functional consequences of altering Notch signalling on insulin secretion and programmed cell death were examined."
+"Thyroid hormone synthesis","Insulin secretion pathway","Thyroid hormone synthesis AND Insulin secretion AND crosstalk ","20689414","no","no","","","","","","","","","","","","","The full paper was not read because insulin was only mentioned indirectly in the abstract.",""
+"Insulin secretion pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Insulin secretion AND crosstalk","20689414","no","no","","","","","","","","","","","","","The full paper was not read because insulin was only mentioned indirectly in the abstract.",""
+"Thyroid hormone synthesis","Insulin secretion pathway","Thyroid hormone synthesis AND Insulin secretion AND crosstalk","772531","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned thyroid indirectly.",""
+"Insulin secretion pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Insulin secretion AND crosstalk","772531","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned thyroid indirectly.",""
+"Thyroid hormone synthesis","Insulin secretion pathway","Thyroid hormone synthesis AND Insulin secretion AND pathway","23864495","no","no","","","","","","","","","","","","","The full text was not read because thyroid was only mentioned indirectly.",""
+"Insulin secretion pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Insulin secretion AND pathway","23864495","no","no","","","","","","","","","","","","","The full text was not read because thyroid was only mentioned indirectly.",""
+"Thyroid hormone synthesis","Insulin secretion pathway","Thyroid hormone synthesis AND Insulin secretion AND pathway","25506600","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin secretion pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Insulin secretion AND pathway","25506600","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Insulin secretion pathway","Thyroid hormone synthesis AND Insulin secretion AND pathway","25241124","no","no","","","","","","","","","","","","","Crosstalk was only found in the other direction.",""
+"Insulin secretion pathway","Thyroid hormone synthesis","Thyroid hormone synthesis AND Insulin secretion AND pathway","25241124","yes","no","activating","Gcg","P55095","UNIPROT","Dio3","Q91ZI8","UNIPROT","Mus musculus","insulinoma cell","BTO:0000632","normal","","The paper doesn't provide many details, but it seems that GLP-1 has a direct effect on  D3 activiy.","In the present study, GLP-1 rapidly stimulated D3 mRNA and D3 activity in dose-dependent manners, although GLP-1 did not affect D1 expression in MIN6 cells."
+"mTOR signaling pathway","Insulin secretion pathway","mTOR AND Insulin secretion AND crosstalk","23776620","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned crosstalk between wnt and mTOR",""
+"Insulin secretion pathway","mTOR signaling pathway","mTOR AND Insulin secretion AND crosstalk","23776620","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned crosstalk between wnt and mTOR",""
+"mTOR signaling pathway","Insulin secretion pathway","mTOR AND Insulin secretion AND pathway","25945932","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned insulin indirectly",""
+"Insulin secretion pathway","mTOR signaling pathway","mTOR AND Insulin secretion AND pathway","25945932","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned insulin indirectly",""
+"mTOR signaling pathway","Insulin secretion pathway","mTOR AND Insulin secretion AND pathway","25553410","no","no","","","","","","","","","","","","","The full text was not read because insulin was only mentioned indirectly in the abstract",""
+"Insulin secretion pathway","mTOR signaling pathway","mTOR AND Insulin secretion AND pathway","25553410","no","no","","","","","","","","","","","","","The full text was not read because insulin was only mentioned indirectly in the abstract",""
+"mTOR signaling pathway","Insulin secretion pathway","mTOR AND Insulin secretion AND pathway","22645144","yes","no","","","","","","","","Rattus norvegicus","pancreatic islet","BTO:0000991","unclear","In this study we found that leucine also regulates pancreatic insulin release through the mTOR pathway and α2AR.","The paper suggests crosstalk, but does not provide any details.",""
+"Insulin secretion pathway","mTOR signaling pathway","mTOR AND Insulin secretion AND pathway","22645144","no","no","","","","","","","","","","","","","The paper only suggested crosstalk in one direction",""
+"mTOR signaling pathway","Insulin secretion pathway","mTOR AND Insulin secretion AND pathway","26756219","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentions the insulin pathway, not insulin secretion",""
+"Insulin secretion pathway","mTOR signaling pathway","mTOR AND Insulin secretion AND pathway","26756219","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentions the insulin pathway, not insulin secretion",""
+"Adipocytokine signaling pathway","Insulin secretion pathway","Adipocytokine AND Insulin secretion AND crosstalk","12379502","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned crosstalk between adipocytokine and the insulin pathway, not insulin secretion",""
+"Insulin secretion pathway","Adipocytokine signaling pathway","Adipocytokine AND Insulin secretion AND crosstalk","12379502","no","no","","","","","","","","","","","","","The full paper was not read because the abstract only mentioned crosstalk between adipocytokine and the insulin pathway, not insulin secretion",""
+"Adipocytokine signaling pathway","Insulin secretion pathway","Adipocytokine AND Insulin secretion AND crosstalk","14671216","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not mention any interactions between the pathways",""
+"Insulin secretion pathway","Adipocytokine signaling pathway","Adipocytokine AND Insulin secretion AND crosstalk","14671216","no","no","","","","","","","","","","","","","The full paper was not read because the abstract did not mention any interactions between the pathways",""
+"Adipocytokine signaling pathway","Insulin secretion pathway","Adipocytokine AND Insulin secretion AND crosstalk","23281828","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any interactions",""
+"Insulin secretion pathway","Adipocytokine signaling pathway","Adipocytokine AND Insulin secretion AND crosstalk","23281828","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any interactions",""
+"Adipocytokine signaling pathway","Insulin secretion pathway","Adipocytokine AND Insulin secretion AND crosstalk","19183933","no","no","","","","","","","","","","","","","The full text was not read because there was not any indication of interactions in the abstract",""
+"Insulin secretion pathway","Adipocytokine signaling pathway","Adipocytokine AND Insulin secretion AND crosstalk","19183933","no","no","","","","","","","","","","","","","The full text was not read because there was not any indication of interactions in the abstract",""
+"Adipocytokine signaling pathway","Insulin secretion pathway","Adipocytokine AND Insulin secretion AND pathway","16736128","no","no","","","","","","","","","","","","","The full text was not read because adipocytokine was not really mentioned in the abstract",""
+"Insulin secretion pathway","Adipocytokine signaling pathway","Adipocytokine AND Insulin secretion AND pathway","16736128","no","no","","","","","","","","","","","","","The full text was not read because adipocytokine was not really mentioned in the abstract",""
+"ErbB signaling pathway","Insulin secretion pathway","ErbB AND Insulin secretion AND pathway","21852536","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin secretion pathway","ErbB signaling pathway","ErbB AND Insulin secretion AND pathway","21852536","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"ErbB signaling pathway","Insulin secretion pathway","ErbB AND Insulin secretion AND pathway","12356750","no","no","","","","","","","","","","","","","The full text was not read because that abstract only mentions the insulin pathway, not insulin secretion",""
+"Insulin secretion pathway","ErbB signaling pathway","ErbB AND Insulin secretion AND pathway","12356750","no","no","","","","","","","","","","","","","The full text was not read because that abstract only mentions the insulin pathway, not insulin secretion",""
+"ErbB signaling pathway","Insulin secretion pathway","ErbB AND Insulin secretion AND pathway","3002607","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of insulin in the abstract",""
+"Insulin secretion pathway","ErbB signaling pathway","ErbB AND Insulin secretion AND pathway","3002607","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of insulin in the abstract",""
+"Estrogen signaling pathway","Insulin secretion pathway","Estrogen AND Insulin secretion AND crosstalk","19721202","no","no","","","","","","","","","","","","","The full text was not read because estrogen was hardly mentioned in the abstract",""
+"Insulin secretion pathway","Estrogen signaling pathway","Estrogen AND Insulin secretion AND crosstalk","19721202","no","no","","","","","","","","","","","","","The full text was not read because estrogen was hardly mentioned in the abstract",""
+"Estrogen signaling pathway","Insulin secretion pathway","Estrogen AND Insulin secretion AND crosstalk","18367392","no","no","","","","","","","","","","","","","The full text was not read because the abstract only talks about the insulin pathway",""
+"Insulin secretion pathway","Estrogen signaling pathway","Estrogen AND Insulin secretion AND crosstalk","18367392","no","no","","","","","","","","","","","","","The full text was not read because the abstract only talks about the insulin pathway",""
+"Estrogen signaling pathway","Insulin secretion pathway","Estrogen AND Insulin secretion AND crosstalk","18571346","no","no","","","","","","","","","","","","","The full text was not read because only the insulin pathway was mentioned in the abstract",""
+"Insulin secretion pathway","Estrogen signaling pathway","Estrogen AND Insulin secretion AND crosstalk","18571346","no","no","","","","","","","","","","","","","The full text was not read because only the insulin pathway was mentioned in the abstract",""
+"Estrogen signaling pathway","Insulin secretion pathway","Estrogen AND Insulin secretion AND pathway","22966069","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not indicate any interactions between the pathways",""
+"Insulin secretion pathway","Estrogen signaling pathway","Estrogen AND Insulin secretion AND pathway","22966069","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not indicate any interactions between the pathways",""
+"Estrogen signaling pathway","Insulin secretion pathway","Estrogen AND Insulin secretion AND pathway","24973798","no","no","","","","","","","","","","","","","The full text was not read because only the insulin pathway was mentioned in the abstract",""
+"Insulin secretion pathway","Estrogen signaling pathway","Estrogen AND Insulin secretion AND pathway","24973798","no","no","","","","","","","","","","","","","The full text was not read because only the insulin pathway was mentioned in the abstract",""
+"GnRH signaling pathway","Insulin secretion pathway","GnRH AND Insulin secretion AND crosstalk","20953065","no","no","","","","","","","","","","","","","The full text was not read because insulin was only mentioned indirectly in the abstract",""
+"Insulin secretion pathway","GnRH signaling pathway","GnRH AND Insulin secretion AND crosstalk","20953065","no","no","","","","","","","","","","","","","The full text was not read because insulin was only mentioned indirectly in the abstract",""
+"GnRH signaling pathway","Insulin secretion pathway","GnRH AND Insulin secretion AND crosstalk","4358345","no","no","","","","","","","","","","","","","The full paper was not read because the abstract mainly talked about pituitary hormones and didn't really mention insulin",""
+"Insulin secretion pathway","GnRH signaling pathway","GnRH AND Insulin secretion AND crosstalk","4358345","no","no","","","","","","","","","","","","","The full paper was not read because the abstract mainly talked about pituitary hormones and didn't really mention insulin",""
+"GnRH signaling pathway","Insulin secretion pathway","GnRH AND Insulin secretion AND crosstalk","18571346","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the insulin pathway, not insulin secretion",""
+"Insulin secretion pathway","GnRH signaling pathway","GnRH AND Insulin secretion AND crosstalk","18571346","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the insulin pathway, not insulin secretion",""
+"GnRH signaling pathway","Insulin secretion pathway","GnRH AND Insulin secretion AND pathway","23518923","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the other pathways interacting with other things",""
+"Insulin secretion pathway","GnRH signaling pathway","GnRH AND Insulin secretion AND pathway","23518923","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the other pathways interacting with other things",""
+"GnRH signaling pathway","Insulin secretion pathway","GnRH AND Insulin secretion AND pathway","17785360","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not give any indication of potential interactions between the two pathways",""
+"Insulin secretion pathway","GnRH signaling pathway","GnRH AND Insulin secretion AND pathway","17785360","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not give any indication of potential interactions between the two pathways",""
+"HIF-1 signaling pathway","Insulin secretion pathway","HIF-1 AND Insulin secretion AND pathway","22834840","","","","","","","","","","","","","","","Article was not available but has been requested",""
+"Insulin secretion pathway","HIF-1 signaling pathway","HIF-1 AND Insulin secretion AND pathway","22834840","","","","","","","","","","","","","","","Article was not available but has been requested",""
+"HIF-1 signaling pathway","Insulin secretion pathway","HIF-1 AND Insulin secretion AND pathway","25801485","unclear","no","activating","HIF1A","Q16665","UNIPROT","","","","Homo sapiens","","","","","The paper doesn't explicitly say that the two interact, so the crosstalk is unclear","Increased HIF1-α level increased ARNT expression and also improved insulin secretion"
+"Insulin secretion pathway","HIF-1 signaling pathway","HIF-1 AND Insulin secretion AND pathway","25801485","no","no","","","","","","","","","","","","","The suggested crosstalk seemed to only be in the other direction",""
+"HIF-1 signaling pathway","Insulin secretion pathway","HIF-1 AND Insulin secretion AND pathway","22581719","no","no","","","","","","","","","","","","","The full text was not read because HIF1 was hardly mentioned in the abstract and not in the same context as insulin",""
+"Insulin secretion pathway","HIF-1 signaling pathway","HIF-1 AND Insulin secretion AND pathway","22581719","no","no","","","","","","","","","","","","","The full text was not read because HIF1 was hardly mentioned in the abstract and not in the same context as insulin",""
+"HIF-1 signaling pathway","Insulin secretion pathway","HIF-1 AND Insulin secretion AND pathway","23977255","no","no","","","","","","","","","","","","","The full text was not read because there was hardly any mention of either pathway and not in the same context",""
+"Insulin secretion pathway","HIF-1 signaling pathway","HIF-1 AND Insulin secretion AND pathway","23977255","no","no","","","","","","","","","","","","","The full text was not read because there was hardly any mention of either pathway and not in the same context",""
+"HIF-1 signaling pathway","Insulin secretion pathway","HIF-1 AND Insulin secretion AND pathway","21059654","yes","unknown","activating","HIF1A","Q16665","UNIPROT","","","","Homo sapiens","pancreatic beta cell","BTO:0000783","normal","Our data support the concept that reducing ARNT/HIF-1β expression inhibits insulin secretion by lowering glucose-stimulated anaplerosis without affecting glucose oxidation and ATP production.","The crosstalk isn't completely clear, but HIF-1 does seem to have an effect on insulin secretion",""
+"Insulin secretion pathway","HIF-1 signaling pathway","HIF-1 AND Insulin secretion AND pathway","21059654","no","no","","","","","","","","","","","","","The crosstalk only seemed to be in one direction",""
+"Jak-STAT signaling pathway","mTOR signaling pathway","Jak-STAT AND mTOR AND pathway","25146167","no","no","","","","","","","","","","","","","The paper suggested crosstalk, but did not provide any support or details","We investigated the significance of PI3K/AKT/mTOR pathway and its interactions with MAPK, JAK/STAT and Notch pathways in meningioma progression."
+"mTOR signaling pathway","Jak-STAT signaling pathway","Jak-STAT AND mTOR AND pathway","25146167","no","no","","","","","","","","","","","","","The paper suggested crosstalk, but did not provide any support or details","We investigated the significance of PI3K/AKT/mTOR pathway and its interactions with MAPK, JAK/STAT and Notch pathways in meningioma progression."
+"Jak-STAT signaling pathway","mTOR signaling pathway","Jak-STAT AND mTOR AND pathway","26398764","no","no","","","","","","","","","","","","","The full text was not read because mTOR was hardly mentioned in the abstract",""
+"mTOR signaling pathway","Jak-STAT signaling pathway","Jak-STAT AND mTOR AND pathway","26398764","no","no","","","","","","","","","","","","","The full text was not read because mTOR was hardly mentioned in the abstract",""
+"Jak-STAT signaling pathway","mTOR signaling pathway","Jak-STAT AND mTOR AND pathway","22402124","no","no","","","","","","","","","","","","","The paper suggested crosstalk, but did not give any support or details","We showed that IL-2–induced telomerase activation involves transcriptional and posttranslational regulation through dual signaling pathways, JAK/STAT and JAK/PI3K/AKT/HSP90/mTORC1"
+"mTOR signaling pathway","Jak-STAT signaling pathway","Jak-STAT AND mTOR AND pathway","22402124","no","no","","","","","","","","","","","","","The paper suggested crosstalk, but did not give any support or details","We showed that IL-2–induced telomerase activation involves transcriptional and posttranslational regulation through dual signaling pathways, JAK/STAT and JAK/PI3K/AKT/HSP90/mTORC1"
+"Jak-STAT signaling pathway","mTOR signaling pathway","Jak-STAT AND mTOR AND pathway","24795729","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention Jak-STAT",""
+"mTOR signaling pathway","Jak-STAT signaling pathway","Jak-STAT AND mTOR AND pathway","24795729","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention Jak-STAT",""
+"Jak-STAT signaling pathway","mTOR signaling pathway","Jak-STAT AND mTOR AND pathway","22575147","no","no","","","","","","","","","","","","","The full text was not read because in the abstract mTOR was only mentioned arbitrarily",""
+"mTOR signaling pathway","Jak-STAT signaling pathway","Jak-STAT AND mTOR AND pathway","22575147","no","no","","","","","","","","","","","","","The full text was not read because in the abstract mTOR was only mentioned arbitrarily",""
+"Neurotrophin signaling pathway","mTOR signaling pathway","Neurotrophin AND mTOR AND pathway","26440805","yes","no","unknown","Ntrk2","P15209","UNIPROT","Mtor","Q9JLN9","UNIPROT","Mus musculus","HT-22 cell","BTO:0003037","glutamate toxicity","To figure out whether HupA protected HT22 cells from oxidative glutamate toxicity via mediating BDNF/TrkB-PI3 K/Akt signaling pathway, we further detected the phosphorylations of Akt, mTOR, and p70s6 kinase in the presence of TrkB IgG or PI3 K inhibitor LY294002.","The paper seems clear that there is some kind of relationship, but it is hard to tell if it is positive or negative",""
+"mTOR signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND mTOR AND pathway","26440805","no","no","","","","","","","","","","","","","The crosstalk only seemed to be in one direction",""
+"Neurotrophin signaling pathway","mTOR signaling pathway","Neurotrophin AND mTOR AND pathway","27035647","no","no","","","","","","","","","","","","","The paper suggests crosstalk, but does not give any evidence","These results suggest that mTOR inhibition may protect photoreceptor cells from neurotrophin withdrawal."
+"mTOR signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND mTOR AND pathway","27035647","no","no","","","","","","","","","","","","","The paper suggests crosstalk, but does not give any evidence","These results suggest that mTOR inhibition may protect photoreceptor cells from neurotrophin withdrawal."
+"Neurotrophin signaling pathway","mTOR signaling pathway","Neurotrophin AND mTOR AND pathway","27090655","no","no","","","","","","","","","","","","","The full text was not read because neurotrophin was hardly mentioned in the abstract",""
+"mTOR signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND mTOR AND pathway","27090655","no","no","","","","","","","","","","","","","The full text was not read because neurotrophin was hardly mentioned in the abstract",""
+"Neurotrophin signaling pathway","mTOR signaling pathway","Neurotrophin AND mTOR AND pathway","26309555","no","no","","","","","","","","","","","","","The full text was not read because there was only brief mention of both pathways and no indication that they interact in the abstract",""
+"mTOR signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND mTOR AND pathway","26309555","no","no","","","","","","","","","","","","","The full text was not read because there was only brief mention of both pathways and no indication that they interact in the abstract",""
+"Neurotrophin signaling pathway","mTOR signaling pathway","Neurotrophin AND mTOR AND pathway","26984631","no","no","","","","","","","","","","","","","The full text was not read because there was only very brief mention of the pathways and there was no suggested interactions in the abstract",""
+"mTOR signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND mTOR AND pathway","26984631","no","no","","","","","","","","","","","","","The full text was not read because there was only very brief mention of the pathways and there was no suggested interactions in the abstract",""
+"NF-kappa B signaling pathway","mTOR signaling pathway","NF-kappa B AND mTOR AND pathway","26296882","no","no","","","","","","","","","","","","","The paper suggests crosstalk, but only describes indirect interactions",""
+"mTOR signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND mTOR AND pathway","26296882","no","no","","","","","","","","","","","","","The paper suggests crosstalk, but only describes indirect interactions",""
+"NF-kappa B signaling pathway","mTOR signaling pathway","NF-kappa B AND mTOR AND pathway","25333576","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned each pathway interacting with something else",""
+"mTOR signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND mTOR AND pathway","25333576","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned each pathway interacting with something else",""
+"NF-kappa B signaling pathway","mTOR signaling pathway","NF-kappa B AND mTOR AND pathway","23538752","no","no","","","","","","","","","","","","","Crosstalk seems to only be in one direction",""
+"mTOR signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND mTOR AND pathway","23538752","yes","no","inhibiting","MTOR","P42345","UNIPROT","NFKB1","P19838","UNIPROT","Homo sapiens","hematopoietic cell","BTO:0000574","cancer","These data are indicative of an increase in canonical NF-κB transcriptional activity upon mTOR inhibition or deficiency.","It seems that there is a direct effect on NF-kappa B by mTOR",""
+"NF-kappa B signaling pathway","mTOR signaling pathway","NF-kappa B AND mTOR AND pathway","25428582","","","","","","","","","","","","","","","The article has been requested through the library",""
+"mTOR signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND mTOR AND pathway","25428582","","","","","","","","","","","","","","","The article has been requested through the library",""
+"NF-kappa B signaling pathway","mTOR signaling pathway","NF-kappa B AND mTOR AND pathway","26204835","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the pathways interacting with something else",""
+"mTOR signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND mTOR AND pathway","26204835","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the pathways interacting with something else",""
+"Prolactin signaling pathway","mTOR signaling pathway","Prolactin AND mTOR AND pathway","26983879","no","no","","","","","","","","","","","","","The full text was not read because there was only brief mention of mTOR in the abstract",""
+"mTOR signaling pathway","Prolactin signaling pathway","Prolactin AND mTOR AND pathway","26983879","no","no","","","","","","","","","","","","","The full text was not read because there was only brief mention of mTOR in the abstract",""
+"Prolactin signaling pathway","mTOR signaling pathway","Prolactin AND mTOR AND pathway","25998028","no","no","","","","","","","","","","","","","The full text was not read because mTOR was not mentioned in the abstract",""
+"mTOR signaling pathway","Prolactin signaling pathway","Prolactin AND mTOR AND pathway","25998028","no","no","","","","","","","","","","","","","25998028",""
+"Prolactin signaling pathway","mTOR signaling pathway","Prolactin AND mTOR AND pathway","26513171","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentions each pathway and both in a different context",""
+"mTOR signaling pathway","Prolactin signaling pathway","Prolactin AND mTOR AND pathway","26513171","no","no","","","","","","","","","","","","","The full text was not read because the abstract only briefly mentions each pathway and both in a different context",""
+"Prolactin signaling pathway","mTOR signaling pathway","Prolactin AND mTOR AND pathway","26765535","no","no","","","","","","","","","","","","","The full text was not read because mTOR was only briefly mentioned and not in a significant way",""
+"mTOR signaling pathway","Prolactin signaling pathway","Prolactin AND mTOR AND pathway","26765535","no","no","","","","","","","","","","","","","The full text was not read because mTOR was only briefly mentioned and not in a significant way",""
+"Prolactin signaling pathway","mTOR signaling pathway","Prolactin AND mTOR AND pathway","23284171","no","no","","","","","","","","","","","","","The full text was not read because the abstract only suggests indirect interactions",""
+"mTOR signaling pathway","Prolactin signaling pathway","Prolactin AND mTOR AND pathway","23284171","no","no","","","","","","","","","","","","","The full text was not read because the abstract only suggests indirect interactions",""
+"TGF-beta signaling pathway","mTOR signaling pathway","TGF-beta AND mTOR AND crosstalk","25127907","no","no","","","","","","","","","","","","","The text suggests crosstalk, but then does not provide any details","3-MA blocked the phosphorylation of both AKT and mTOR and partly reduced the inhibitory effect of TGF-β1 on the expression of LC3 II/I and cleaved caspase-3."
+"mTOR signaling pathway","TGF-beta signaling pathway","TGF-beta AND mTOR AND crosstalk","25127907","no","no","","","","","","","","","","","","","The text suggests crosstalk, but then does not provide any details","3-MA blocked the phosphorylation of both AKT and mTOR and partly reduced the inhibitory effect of TGF-β1 on the expression of LC3 II/I and cleaved caspase-3."
+"TGF-beta signaling pathway","mTOR signaling pathway","TGF-beta AND mTOR AND pathway","26884601","yes","no","inhibiting","[TGFBR1/TGFBR2]","[P36897/P37173]","UNIPROT","MTOR","P42345","UNIPROT","Homo sapiens","natural killer cell","BTO:0000914","normal","This effect occurred with the same kinetics as did the phosphorylation of SMAD2/3, suggesting that mTOR inhibition occurred just downstream of TGF-βR activation.","There seems to be some direct interaction between the two pathways having an effect on mTOR",""
+"mTOR signaling pathway","TGF-beta signaling pathway","TGF-beta AND mTOR AND pathway","26884601","no","no","","","","","","","","","","","","","There only seemed to be crosstalk in one direction",""
+"TGF-beta signaling pathway","mTOR signaling pathway","TGF-beta AND mTOR AND pathway","26986649","","","","","","","","","","","","","","","The article was not available but has been requested",""
+"mTOR signaling pathway","TGF-beta signaling pathway","TGF-beta AND mTOR AND pathway","26986649","","","","","","","","","","","","","","","The article was not available but has been requested",""
+"TGF-beta signaling pathway","mTOR signaling pathway","TGF-beta AND mTOR AND pathway","27040186","no","no","","","","","","","","","","","","","The full text was not read because the pathways were both mentioned in a different context",""
+"mTOR signaling pathway","TGF-beta signaling pathway","TGF-beta AND mTOR AND pathway","27040186","no","no","","","","","","","","","","","","","The full text was not read because the pathways were both mentioned in a different context",""
+"TGF-beta signaling pathway","mTOR signaling pathway","TGF-beta AND mTOR AND pathway","25569154","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned indirect interactions between the two pathways",""
+"mTOR signaling pathway","TGF-beta signaling pathway","TGF-beta AND mTOR AND pathway","25569154","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned indirect interactions between the two pathways",""
+"TNF signaling pathway","mTOR signaling pathway","TNF AND mTOR AND pathway","26407598","no","no","","","","","","","","","","","","","The full text was not read because there was not mention of TNF in the abstract",""
+"mTOR signaling pathway","TNF signaling pathway","TNF AND mTOR AND pathway","26407598","no","no","","","","","","","","","","","","","The full text was not read because there was not mention of TNF in the abstract",""
+"TNF signaling pathway","mTOR signaling pathway","TNF AND mTOR AND pathway","25770080","no","no","","","","","","","","","","","","","The crosstalk only seemed to be in the other direction",""
+"mTOR signaling pathway","TNF signaling pathway","TNF AND mTOR AND pathway","25770080","yes","yes","activating","Mtor","Q9JLN9","UNIPROT","Tnf","P06804","UNIPROT","Mus musculus","astrocyte","BTO:0000099","proliferation","Administration of rapamycin significantly decreased levels of TNF-α after SCI and contributed to functional recovery from the injury","Since rapamycin inhibits mTOR and decreases levels of TNF, the relationship is positive",""
+"TNF signaling pathway","mTOR signaling pathway","TNF AND mTOR AND pathway","27113683","no","no","","","","","","","","","","","","","The full text was not read because TNF was only briefly mentioned and for nothing significant",""
+"mTOR signaling pathway","TNF signaling pathway","TNF AND mTOR AND pathway","27113683","no","no","","","","","","","","","","","","","The full text was not read because TNF was only briefly mentioned and for nothing significant",""
+"TNF signaling pathway","mTOR signaling pathway","TNF AND mTOR AND pathway","25861954","no","no","","","","","","","","","","","","","The full text was not read because TNF was only briefly mentioned in the abstract and not for anything significant",""
+"mTOR signaling pathway","TNF signaling pathway","TNF AND mTOR AND pathway","25861954","no","no","","","","","","","","","","","","","The full text was not read because TNF was only briefly mentioned in the abstract and not for anything significant",""
+"TNF signaling pathway","mTOR signaling pathway","TNF AND mTOR AND pathway","26440402","no","no","","","","","","","","","","","","","The full text was not read because TNF was only briefly mentioned in the abstract and not in the same context as mTOR",""
+"mTOR signaling pathway","TNF signaling pathway","TNF AND mTOR AND pathway","26440402","no","no","","","","","","","","","","","","","The full text was not read because TNF was only briefly mentioned in the abstract and not in the same context as mTOR",""
+"Toll-like receptor signaling pathway","mTOR signaling pathway","Toll-like receptor AND mTOR AND pathway","25637945","no","no","","","","","","","","","","","","","The full text was not read because mTOR was only briefly mentioned and not in a significant way",""
+"mTOR signaling pathway","Toll-like receptor signaling pathway","Toll-like receptor AND mTOR AND pathway","25637945","no","no","","","","","","","","","","","","","The full text was not read because mTOR was only briefly mentioned and not in a significant way",""
+"Toll-like receptor signaling pathway","mTOR signaling pathway","Toll-like receptor AND mTOR AND pathway","26857578","no","no","","","","","","","","","","","","","The article suggested crosstalk, but did not provide any real evidence for it",""
+"mTOR signaling pathway","Toll-like receptor signaling pathway","Toll-like receptor AND mTOR AND pathway","26857578","no","no","","","","","","","","","","","","","The article suggested crosstalk, but did not provide any real evidence for it",""
+"Toll-like receptor signaling pathway","mTOR signaling pathway","Toll-like receptor AND mTOR AND pathway","26900402","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned mTOR briefly and not in a significant context",""
+"mTOR signaling pathway","Toll-like receptor signaling pathway","Toll-like receptor AND mTOR AND pathway","26900402","","","","","","","","","","","","","","","The full text was not read because mTOR was only briefly mentioned in the abstract and not in a significant context",""
+"Toll-like receptor signaling pathway","mTOR signaling pathway","Toll-like receptor AND mTOR AND pathway","26849067","no","no","","","","","","","","","","","","","Crosstalk only seems to be in the other direction",""
+"mTOR signaling pathway","Toll-like receptor signaling pathway","Toll-like receptor AND mTOR AND pathway","26849067","yes","no","activating","Mtor","P42346","UNIPROT","Tlr4","Q9QX05","UNIPROT","Rattus norvegicus","kidney","BTO:0000671","diabetic nephropathy","Taken together, our study suggests that activation of TLR4 has a striking effect on the early stage development of DN, and could be suppressed by mTOR inhibitor rapamycin.","Because rapamycin inhibits both pathways, the relationship would be positive",""
+"Toll-like receptor signaling pathway","mTOR signaling pathway","Toll-like receptor AND mTOR AND pathway","26489461","yes","no","activating","Tlr2","Q9QUN7","UNIPROT","Mtor","Q9JLN9","UNIPROT","Mus musculus","neuron","BTO:0000938","neurodegeneration","Surprisingly, the phosphorylation of mTOR (S2481) was increased by activation of TLR2 in dSY5Y cells","There seems to be a direct relationship between the two pathways",""
+"mTOR signaling pathway","Toll-like receptor signaling pathway","Toll-like receptor AND mTOR AND pathway","26489461","no","no","","","","","","","","","","","","","The crosstalk only seemed to be in one direction",""
+"VEGF signaling pathway","mTOR signaling pathway","VEGF AND mTOR AND crosstalk","19717640","yes","no","activating","VEGFC","P49767","UNIPROT","MTOR","P42345","UNIPROT","Homo sapiens","lung","BTO:0000763","LAM cell proliferation","VEGF-C treatment of LDC induced phosphorylation of Akt, mTOR, S6 kinase (S6K), S6 ribosomal protein","VEF-C seems to have a direct effect on the phosphorylation of mTOR",""
+"mTOR signaling pathway","VEGF signaling pathway","VEGF AND mTOR AND crosstalk","19717640","no","no","","","","","","","","","","","","","There was only crosstalk in the other direction",""
+"VEGF signaling pathway","mTOR signaling pathway","VEGF AND mTOR AND crosstalk","23110808","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context",""
+"mTOR signaling pathway","VEGF signaling pathway","VEGF AND mTOR AND crosstalk","23110808","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context",""
+"VEGF signaling pathway","mTOR signaling pathway","VEGF AND mTOR AND crosstalk","19595306","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"mTOR signaling pathway","VEGF signaling pathway","VEGF AND mTOR AND crosstalk","19595306","no","no","","","","","","","","","","","","","The full text was not read because both pathways were mentioned in a different context in the abstract",""
+"VEGF signaling pathway","mTOR signaling pathway","VEGF AND mTOR AND pathway","26142874","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only mentioned independently in the abstract",""
+"mTOR signaling pathway","VEGF signaling pathway","VEGF AND mTOR AND pathway","26142874","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only mentioned independently in the abstract",""
+"VEGF signaling pathway","mTOR signaling pathway","VEGF AND mTOR AND pathway","25913131","no","no","","","","","","","","","","","","","The full text was not read because VEGF was not mentioned in the abstract",""
+"mTOR signaling pathway","VEGF signaling pathway","VEGF AND mTOR AND pathway","25913131","no","no","","","","","","","","","","","","","The full text was not read because VEGF was not mentioned in the abstract",""
+"Wnt signaling pathway","mTOR signaling pathway","Wnt AND mTOR AND crosstalk","26859571","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned crosstalk between mTOR and hedgehog",""
+"mTOR signaling pathway","Wnt signaling pathway","Wnt AND mTOR AND crosstalk","26859571","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned crosstalk between mTOR and hedgehog",""
+"Wnt signaling pathway","mTOR signaling pathway","Wnt AND mTOR AND crosstalk","26957369","no","no","","","","","","","","","","","","","The full text was not read because the abstract only lists the pathways and doesn't suggest crosstalk",""
+"mTOR signaling pathway","Wnt signaling pathway","Wnt AND mTOR AND crosstalk","26957369","no","no","","","","","","","","","","","","","The full text was not read because the abstract just listed the pathways and didn't suggest any interactions",""
+"Wnt signaling pathway","mTOR signaling pathway","Wnt AND mTOR AND crosstalk","23776620","no","no","","","","","","","","","","","","","The text suggests crosstalk, but gives no details or explanation",""
+"mTOR signaling pathway","Wnt signaling pathway","Wnt AND mTOR AND crosstalk","23776620","no","no","","","","","","","","","","","","","The text suggests crosstalk, but gives no details or explanation",""
+"Wnt signaling pathway","mTOR signaling pathway","Wnt AND mTOR AND crosstalk","17993259","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk between the two pathways",""
+"mTOR signaling pathway","Wnt signaling pathway","Wnt AND mTOR AND crosstalk","17993259","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk between the two pathways",""
+"Wnt signaling pathway","mTOR signaling pathway","Wnt AND mTOR AND crosstalk","24180397","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only listed and not suggested to interact in the abstract",""
+"mTOR signaling pathway","Wnt signaling pathway","Wnt AND mTOR AND crosstalk","24180397","no","no","","","","","","","","","","","","","The full text was not read because both pathways were only listed and not suggested to interact in the abstract",""
+"NF-kappa B signaling pathway","Adherens junction","NF-kappa B AND Adherens AND pathway","25427801","yes","yes","inhibiting","dl","P15330","UNIPROT","shg","Q24298","UNIPROT","Drosophila melanogaster","epidermis","BTO:0000404","embryonic, wound repair","Toll mutants and Dif dorsal (NF-κB) double mutants are unable to repair epidermal gaps. Dorsal is activated on wounding, and Dif and Dorsal are required for the sustained down-regulation of E-cadherin, an obligatory component of the adherens junctions (AJs), at the wound edge.","Dorsal and Dif down-regulate E-cadherin in cells around wound so actin can span wound and contract wound margin.",""
+"Adherens junction","NF-kappa B signaling pathway","NF-kappa B AND Adherens AND pathway","25427801","no","","","","","","","","","","","","","","other direction",""
+"Jak-STAT signaling pathway","Insulin secretion pathway","Jak-STAT AND Insulin secretion AND crosstalk","16336196","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not indicate any potential crosstalk",""
+"Insulin secretion pathway","Jak-STAT signaling pathway","Jak-STAT AND Insulin secretion AND crosstalk","16336196","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not indicate any potential crosstalk",""
+"Jak-STAT signaling pathway","Insulin secretion pathway","Jak-STAT AND Insulin secretion AND pathway","22849859","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned Jak-STAT and its effect on differentiation of cells",""
+"Insulin secretion pathway","Jak-STAT signaling pathway","Jak-STAT AND Insulin secretion AND pathway","22849859","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned Jak-STAT and its effect on differentiation of cells",""
+"Jak-STAT signaling pathway","Insulin secretion pathway","Jak-STAT AND Insulin secretion AND pathway","24531222","no","no","","","","","","","","","","","","","The full text was not read because the abstract barely mentioned insulin and did not suggest any crosstalk",""
+"Insulin secretion pathway","Jak-STAT signaling pathway","Jak-STAT AND Insulin secretion AND pathway","24531222","no","no","","","","","","","","","","","","","The full text was not read because the abstract barely mentioned insulin and did not suggest any crosstalk",""
+"Jak-STAT signaling pathway","Insulin secretion pathway","Jak-STAT AND Insulin secretion AND pathway","21490369","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned interactions between the two pathways and growth hormone",""
+"Insulin secretion pathway","Jak-STAT signaling pathway","Jak-STAT AND Insulin secretion AND pathway","21490369","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned interactions between the two pathways and growth hormone",""
+"Jak-STAT signaling pathway","Insulin secretion pathway","Jak-STAT AND Insulin secretion AND pathway","24101550","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Insulin secretion pathway","Jak-STAT signaling pathway","Jak-STAT AND Insulin secretion AND pathway","24101550","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"MAPK signaling pathway","Insulin secretion pathway","MAPK AND Insulin secretion AND crosstalk","18310442","no","no","","","","","","","","","","","","","The full text was not read because there was no indication of crosstalk in the abstract",""
+"Insulin secretion pathway","MAPK signaling pathway","MAPK AND Insulin secretion AND crosstalk","18310442","no","no","","","","","","","","","","","","","The full text was not read because there was no indication of crosstalk in the abstract",""
+"MAPK signaling pathway","Insulin secretion pathway","MAPK AND Insulin secretion AND crosstalk","16283237","no","no","","","","","","","","","","","","","The full text was not read because the insulin secretion pathway is not mentioned in the abstract",""
+"Insulin secretion pathway","MAPK signaling pathway","MAPK AND Insulin secretion AND crosstalk","16283237","no","no","","","","","","","","","","","","","The full text was not read because the insulin secretion pathway was not mentioned in the abstract",""
+"MAPK signaling pathway","Insulin secretion pathway","MAPK AND Insulin secretion AND crosstalk","19183933","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of the insulin secretion pathway in the abstract",""
+"Insulin secretion pathway","MAPK signaling pathway","MAPK AND Insulin secretion AND crosstalk","19183933","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of the insulin secretion pathway in the abstract",""
+"MAPK signaling pathway","Insulin secretion pathway","MAPK AND Insulin secretion AND crosstalk","24702479","no","no","","","","","","","","","","","","","The full text was not read because the abstract suggested that the two pathways did not crosstalk",""
+"Insulin secretion pathway","MAPK signaling pathway","MAPK AND Insulin secretion AND crosstalk","24702479","no","no","","","","","","","","","","","","","The full text was not read because the abstract suggested that the two pathways do not crosstalk",""
+"MAPK signaling pathway","Insulin secretion pathway","MAPK AND Insulin secretion AND crosstalk","24623499","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the interaction with each pathway and T3",""
+"Insulin secretion pathway","MAPK signaling pathway","MAPK AND Insulin secretion AND crosstalk","24623499","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the interaction with each pathway and T3",""
+"Neurotrophin signaling pathway","Insulin secretion pathway","Neurotrophin AND Insulin secretion AND pathway","23964269","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of insulin in the abstract",""
+"Insulin secretion pathway","Neurotrophin signaling pathway","Neurotrophin AND Insulin secretion AND pathway","23964269","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of insulin in the abstract",""
+"Neurotrophin signaling pathway","Insulin secretion pathway","Neurotrophin AND Insulin secretion AND pathway","22015157","yes","no","activating","Bdnf","P21237","UNIPROT","","","","Mus musculus","spermatocyte","BTO:0001275","normal","The expression of the leptin receptor in hypothalamic neurons increased after treatment with BDNF, and the intermittent administration of BDNF to mice significantly increased plasma insulin concentrations","The paper isn't very descriptive of the interaction between the two pathways, but it seems that there is some kind of effect on the insulin secretion pathway by BDNF that is not transcriptional",""
+"Insulin secretion pathway","Neurotrophin signaling pathway","Neurotrophin AND Insulin secretion AND pathway","22015157","no","no","","","","","","","","","","","","","There only appears to evidence for crosstalk in one direction",""
+"NF-kappa B signaling pathway","Insulin secretion pathway","NF-kappa B AND Insulin secretion AND crosstalk","16283237","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin secretion pathway","NF-kappa B signaling pathway","NF-kappa B AND Insulin secretion AND crosstalk","16283237","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"NF-kappa B signaling pathway","Insulin secretion pathway","NF-kappa B AND Insulin secretion AND pathway","21999347","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk between the two pathways",""
+"Insulin secretion pathway","NF-kappa B signaling pathway","NF-kappa B AND Insulin secretion AND pathway","21999347","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk between the two pathways",""
+"NF-kappa B signaling pathway","Insulin secretion pathway","NF-kappa B AND Insulin secretion AND pathway","25725372","no","no","","","","","","","","","","","","","The full text was not read because NF-kappa B was not mentioned in the abstract",""
+"Insulin secretion pathway","NF-kappa B signaling pathway","NF-kappa B AND Insulin secretion AND pathway","25725372","no","no","","","","","","","","","","","","","The full text was not read because NF-kappa B was not mentioned in the abstract",""
+"NF-kappa B signaling pathway","Insulin secretion pathway","NF-kappa B AND Insulin secretion AND pathway","26245897","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin secretion pathway","NF-kappa B signaling pathway","NF-kappa B AND Insulin secretion AND pathway","26245897","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"NF-kappa B signaling pathway","Insulin secretion pathway","NF-kappa B AND Insulin secretion AND pathway","24818605","no","no","","","","","","","","","","","","","The full text was not read because NF-kappa B was not mentioned in the abstract",""
+"Insulin secretion pathway","NF-kappa B signaling pathway","NF-kappa B AND Insulin secretion AND pathway","24818605","no","no","","","","","","","","","","","","","The full text was not read because NF-kappa B was not mentioned in the abstract",""
+"Prolactin signaling pathway","Insulin secretion pathway","Prolactin AND Insulin secretion AND crosstalk","24373242","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the interactions between the pathways and growth hormone",""
+"Insulin secretion pathway","Prolactin signaling pathway","Prolactin AND Insulin secretion AND crosstalk","24373242","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the interactions between the pathways and growth hormone",""
+"Prolactin signaling pathway","Insulin secretion pathway","Prolactin AND Insulin secretion AND crosstalk","18571346","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin secretion pathway","Prolactin signaling pathway","Prolactin AND Insulin secretion AND crosstalk","18571346","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Prolactin signaling pathway","Insulin secretion pathway","Prolactin AND Insulin secretion AND pathway","22700767","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned an indirect interaction",""
+"Insulin secretion pathway","Prolactin signaling pathway","Prolactin AND Insulin secretion AND pathway","22700767","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned an indirect interaction",""
+"Prolactin signaling pathway","Insulin secretion pathway","Prolactin AND Insulin secretion AND pathway","26084427","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin secretion pathway","Prolactin signaling pathway","Prolactin AND Insulin secretion AND pathway","26084427","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Prolactin signaling pathway","Insulin secretion pathway","Prolactin AND Insulin secretion AND crosstalk ","4358345","no","no","","","","","","","","","","","","","The full text was not read because there was not mention of insulin secretion in the abstract",""
+"Insulin secretion pathway","Prolactin signaling pathway","Prolactin AND Insulin secretion AND crosstalk","4358345","no","no","","","","","","","","","","","","","The full text was not read because there was not mention of insulin secretion in the abstract",""
+"TGF-beta signaling pathway","Insulin secretion pathway","TGF-beta AND Insulin secretion AND crosstalk","22359515","no","no","","","","","","","","","","","","","The paper suggests crosstalk, but only seems to describe indirect interactions between the two pathways",""
+"Insulin secretion pathway","TGF-beta signaling pathway","TGF-beta AND Insulin secretion AND crosstalk","22359515","no","no","","","","","","","","","","","","","The paper suggests crosstalk, but only seems to describe indirect interactions between the two pathways",""
+"TGF-beta signaling pathway","Insulin secretion pathway","TGF-beta AND Insulin secretion AND crosstalk","24990151","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention insulin secretion",""
+"Insulin secretion pathway","TGF-beta signaling pathway","TGF-beta AND Insulin secretion AND crosstalk","24990151","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention insulin secretion",""
+"TGF-beta signaling pathway","Insulin secretion pathway","TGF-beta AND Insulin secretion AND crosstalk","22859271","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the absract",""
+"Insulin secretion pathway","TGF-beta signaling pathway","TGF-beta AND Insulin secretion AND crosstalk","22859271","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the absract",""
+"TGF-beta signaling pathway","Insulin secretion pathway","TGF-beta AND Insulin secretion AND pathway","24068386","no","no","","","","","","","","","","","","","The full text was not read because the abstract only suggests indirect interactions",""
+"Insulin secretion pathway","TGF-beta signaling pathway","TGF-beta AND Insulin secretion AND pathway","24068386","no","no","","","","","","","","","","","","","The full text was not read because the abstract only suggests indirect interactions",""
+"TGF-beta signaling pathway","Insulin secretion pathway","TGF-beta AND Insulin secretion AND pathway","21106882","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention insulin secretion",""
+"Insulin secretion pathway","TGF-beta signaling pathway","TGF-beta AND Insulin secretion AND pathway","21106882","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not mention insulin secretion",""
+"TNF signaling pathway","Insulin secretion pathway","TNF AND Insulin secretion AND crosstalk","23283583","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of insulin secretion in the abstract",""
+"Insulin secretion pathway","TNF signaling pathway","TNF AND Insulin secretion AND crosstalk","23283583","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of insulin secretion in the abstract",""
+"TNF signaling pathway","Insulin secretion pathway","TNF AND Insulin secretion AND crosstalk","22235273","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin secretion pathway","TNF signaling pathway","TNF AND Insulin secretion AND crosstalk","22235273","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"TNF signaling pathway","Insulin secretion pathway","TNF AND Insulin secretion AND crosstalk","19183933","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin secretion pathway","TNF signaling pathway","TNF AND Insulin secretion AND crosstalk","19183933","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"TNF signaling pathway","Insulin secretion pathway","TNF AND Insulin secretion AND pathway","25725372","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of insulin secretion in the abstract",""
+"Insulin secretion pathway","TNF signaling pathway","TNF AND Insulin secretion AND pathway","25725372","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of insulin secretion in the abstract",""
+"TNF signaling pathway","Insulin secretion pathway","TNF AND Insulin secretion AND pathway","23864495","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin secretion pathway","TNF signaling pathway","TNF AND Insulin secretion AND pathway","23864495","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Toll-like receptor signaling pathway","Insulin secretion pathway","Toll-like receptor AND Insulin secretion AND crosstalk","23242473","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of insulin secretion in the abstract",""
+"Insulin secretion pathway","Toll-like receptor signaling pathway","Toll-like receptor AND Insulin secretion AND crosstalk","23242473","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of insulin secretion in the abstract",""
+"Toll-like receptor signaling pathway","Insulin secretion pathway","Toll-like receptor AND Insulin secretion AND pathway","24337154","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of insulin secretion in the abstract",""
+"Insulin secretion pathway","Toll-like receptor signaling pathway","Toll-like receptor AND Insulin secretion AND pathway","24337154","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of insulin secretion in the abstract",""
+"Toll-like receptor signaling pathway","Insulin secretion pathway","Toll-like receptor AND Insulin secretion AND pathway","25611816","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin secretion pathway","Toll-like receptor signaling pathway","Toll-like receptor AND Insulin secretion AND pathway","25611816","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Toll-like receptor signaling pathway","Insulin secretion pathway","Toll-like receptor AND Insulin secretion AND pathway","22558381","yes","no","inhibiting","Tlr4","Q9QUK6","UNIPROT","","","","Mus musculus","pancreatic islet","BTO:0000991","diabetes","TLR4 signalling has recently been reported to impair insulin secretion and insulin mRNA expression in human islets via its activation by the chemokine CXCL10","The paper does not go into great detail about the crosstalk, but there does seem to be a direct effect on insulin secretion by TLR4",""
+"Insulin secretion pathway","Toll-like receptor signaling pathway","Toll-like receptor AND Insulin secretion AND pathway","22558381","no","no","","","","","","","","","","","","","The crosstalk only seemed to be in one direction",""
+"Toll-like receptor signaling pathway","Insulin secretion pathway","Toll-like receptor AND Insulin secretion AND pathway","23328519","no","no","","","","","","","","","","","","","The full text was not read because there was no suggestion of crosstalk in the abstract",""
+"Insulin secretion pathway","Toll-like receptor signaling pathway","Toll-like receptor AND Insulin secretion AND pathway","23328519","no","no","","","","","","","","","","","","","The full text was not read because there was no suggestion of crosstalk in the abstract",""
+"VEGF signaling pathway","Insulin secretion pathway","VEGF AND Insulin secretion AND crosstalk","26586774","no","no","","","","","","","","","","","","","The full text was not read because there was not mention of insulin secretion in the abstract",""
+"Insulin secretion pathway","VEGF signaling pathway","VEGF AND Insulin secretion AND crosstalk","26586774","no","no","","","","","","","","","","","","","The full text was not read because there was not mention of insulin secretion in the abstract",""
+"VEGF signaling pathway","Insulin secretion pathway","VEGF AND Insulin secretion AND crosstalk","26840553","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin secretion pathway","VEGF signaling pathway","VEGF AND Insulin secretion AND crosstalk","26840553","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"VEGF signaling pathway","Insulin secretion pathway","VEGF AND Insulin secretion AND crosstalk","24990151","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin secretion pathway","VEGF signaling pathway","VEGF AND Insulin secretion AND crosstalk","24990151","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"VEGF signaling pathway","Insulin secretion pathway","VEGF AND Insulin secretion AND crosstalk","26305333","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin secretion pathway","VEGF signaling pathway","VEGF AND Insulin secretion AND crosstalk","26305333","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"VEGF signaling pathway","Insulin secretion pathway","VEGF AND Insulin secretion AND pathway","24126783","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin secretion pathway","VEGF signaling pathway","VEGF AND Insulin secretion AND pathway","24126783","no","no","","","","","","","","","","","","","The full text was not read because insulin secretion was not mentioned in the abstract",""
+"Insulin signaling pathway","Insulin secretion pathway","Insulin AND Insulin secretion AND crosstalk","25176602","no","no","","","","","","","","","","","","","The full text was not read because insulin signaling was not mentioned in the abstract",""
+"Insulin secretion pathway","Insulin signaling pathway","Insulin AND Insulin secretion AND crosstalk","25176602","no","no","","","","","","","","","","","","","The full text was not read because insulin signaling was not mentioned in the abstract",""
+"Insulin signaling pathway","Insulin secretion pathway","Insulin AND Insulin secretion AND crosstalk","24618283","no","no","","","","","","","","","","","","","The full text was not read because insulin signaling was not mentioned in the abstract",""
+"Insulin secretion pathway","Insulin signaling pathway","Insulin AND Insulin secretion AND crosstalk","24618283","no","no","","","","","","","","","","","","","The full text was not read because insulin signaling was not mentioned in the abstract",""
+"Insulin signaling pathway","Insulin secretion pathway","Insulin AND Insulin secretion AND crosstalk","26683831","no","no","","","","","","","","","","","","","The full text was not read because insulin signaling was not mentioned in the abstract",""
+"Insulin secretion pathway","Insulin signaling pathway","Insulin AND Insulin secretion AND crosstalk","26683831","no","no","","","","","","","","","","","","","The full text was not read because insulin signaling was not mentioned in the abstract",""
+"Insulin signaling pathway","Insulin secretion pathway","Insulin AND Insulin secretion AND crosstalk","23159841","no","no","","","","","","","","","","","","","The full text was not read because neither pathway was mentioned in the abstract",""
+"Insulin secretion pathway","Insulin signaling pathway","Insulin AND Insulin secretion AND crosstalk","23159841","no","no","","","","","","","","","","","","","The full text was not read because neither pathway was mentioned in the abstract",""
+"Insulin signaling pathway","Insulin secretion pathway","Insulin AND Insulin secretion AND crosstalk","22399501","no","no","","","","","","","","","","","","","The full text was not read because only insulin and glucagon secretion was mentioned in the abstract",""
+"Insulin secretion pathway","Insulin signaling pathway","Insulin AND Insulin secretion AND crosstalk","22399501","no","no","","","","","","","","","","","","","The full text was not read because only insulin and glucagon secretion was mentioned in the abstract",""
+"mTOR signaling pathway","Thyroid hormone synthesis","mTOR AND Thyroid hormone synthesis AND pathway","22414628","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Thyroid hormone synthesis","mTOR signaling pathway","mTOR AND Thyroid hormone synthesis AND pathway","22414628","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"mTOR signaling pathway","Thyroid hormone synthesis","mTOR AND Thyroid hormone synthesis AND pathway","26499800","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Thyroid hormone synthesis","mTOR signaling pathway","mTOR AND Thyroid hormone synthesis AND pathway","26499800","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"mTOR signaling pathway","Thyroid hormone synthesis","mTOR AND Thyroid hormone synthesis AND pathway","22294347","no","no","","","","","","","","","","","","","The full text was not read because the abstract only suggested indirect interactions",""
+"Thyroid hormone synthesis","mTOR signaling pathway","mTOR AND Thyroid hormone synthesis AND pathway","22294347","no","no","","","","","","","","","","","","","The full text was not read because the abstract only suggested indirect interactions",""
+"mTOR signaling pathway","Thyroid hormone synthesis","mTOR AND Thyroid hormone synthesis AND pathway","25617495","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Thyroid hormone synthesis","mTOR signaling pathway","mTOR AND Thyroid hormone synthesis AND pathway","25617495","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"mTOR signaling pathway","Thyroid hormone synthesis","mTOR AND Thyroid hormone synthesis AND pathway","23762265","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","mTOR signaling pathway","mTOR AND Thyroid hormone synthesis AND pathway","23762265","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"HIF-1 signaling pathway","Thyroid hormone synthesis","HIF-1 AND Thyroid hormone synthesis AND pathway","25748049","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of thyroid hormone synthesis in the abstract",""
+"Thyroid hormone synthesis","HIF-1 signaling pathway","HIF-1 AND Thyroid hormone synthesis AND pathway","25748049","no","no","","","","","","","","","","","","","The full text was not read because there was no mention of thyroid hormone synthesis in the abstract",""
+"HIF-1 signaling pathway","Thyroid hormone synthesis","HIF-1 AND Thyroid hormone synthesis AND pathway","25790097","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","HIF-1 signaling pathway","HIF-1 AND Thyroid hormone synthesis AND pathway","25790097","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"HIF-1 signaling pathway","Thyroid hormone synthesis","HIF-1 AND Thyroid hormone synthesis AND pathway","23762265","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","HIF-1 signaling pathway","HIF-1 AND Thyroid hormone synthesis AND pathway","23762265","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"HIF-1 signaling pathway","Thyroid hormone synthesis","HIF-1 AND Thyroid hormone synthesis AND pathway","24123565","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","HIF-1 signaling pathway","HIF-1 AND Thyroid hormone synthesis AND pathway","24123565","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"HIF-1 signaling pathway","Thyroid hormone synthesis","HIF-1 AND Thyroid hormone synthesis AND pathway","22562152","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","HIF-1 signaling pathway","HIF-1 AND Thyroid hormone synthesis AND pathway","22562152","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Insulin signaling pathway","Thyroid hormone synthesis","Insulin AND Thyroid hormone synthesis AND crosstalk","24808494","no","no","","","","","","","","","","","","","The crosstalk only seemed to be in one direction",""
+"Thyroid hormone synthesis","Insulin signaling pathway","Insulin AND Thyroid hormone synthesis AND crosstalk","24808494","yes","no","inhibiting","T4","hormone","hormone","Igf1","P08025","UNIPROT","Rattus norvegicus","myoblast","BTO:0000222","normal","The principal findings here are that thyroid hormone as T4 inhibits two actions of IGF-I in L6 myoblasts, glucose uptake and proliferation.","The paper does not provide specifics, but there does seem to be crosstalk from thyroid hormone synthesis to insulin",""
+"Insulin signaling pathway","Thyroid hormone synthesis","Insulin AND Thyroid hormone synthesis AND crosstalk","20689414","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Insulin signaling pathway","Insulin AND Thyroid hormone synthesis AND crosstalk","20689414","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Insulin signaling pathway","Thyroid hormone synthesis","Insulin AND Thyroid hormone synthesis AND crosstalk","772531","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Insulin signaling pathway","Insulin AND Thyroid hormone synthesis AND crosstalk","772531","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Insulin signaling pathway","Thyroid hormone synthesis","Insulin AND Thyroid hormone synthesis AND crosstalk","4129284","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Insulin signaling pathway","Insulin AND Thyroid hormone synthesis AND crosstalk","4129284","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Insulin signaling pathway","Thyroid hormone synthesis","Insulin AND Thyroid hormone synthesis AND crosstalk","3292313","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Thyroid hormone synthesis","Insulin signaling pathway","Insulin AND Thyroid hormone synthesis AND crosstalk","3292313","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Insulin signaling pathway","Thyroid hormone synthesis","Insulin AND Thyroid hormone synthesis AND crosstalk","17218720","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Insulin signaling pathway","Insulin AND Thyroid hormone synthesis AND crosstalk","17218720","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Jak-STAT signaling pathway","Thyroid hormone synthesis","Jak-STAT AND Thyroid hormone synthesis AND pathway ","20600149","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Jak-STAT signaling pathway","Jak-STAT AND Thyroid hormone synthesis AND pathway","20600149","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Jak-STAT signaling pathway","Thyroid hormone synthesis","Jak-STAT AND Thyroid hormone synthesis AND pathway","11641425","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Jak-STAT signaling pathway","Jak-STAT AND Thyroid hormone synthesis AND pathway","11641425","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Jak-STAT signaling pathway","Thyroid hormone synthesis","Jak-STAT AND Thyroid hormone synthesis AND pathway","11997231","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Jak-STAT signaling pathway","Jak-STAT AND Thyroid hormone synthesis AND pathway","11997231","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Jak-STAT signaling pathway","Thyroid hormone synthesis","Jak-STAT AND Thyroid hormone synthesis AND pathway","18557974","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Thyroid hormone synthesis","Jak-STAT signaling pathway","Jak-STAT AND Thyroid hormone synthesis AND pathway","18557974","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"MAPK signaling pathway","Thyroid hormone synthesis","MAPK AND Thyroid hormone synthesis AND pathway","25278044","no","no","","","","","","","","","","","","","The paper suggested crosstalk, but only described indirect interactions",""
+"Thyroid hormone synthesis","MAPK signaling pathway","MAPK AND Thyroid hormone synthesis AND pathway","25278044","no","no","","","","","","","","","","","","","The paper suggested crosstalk, but only described indirect interactions",""
+"MAPK signaling pathway","Thyroid hormone synthesis","MAPK AND Thyroid hormone synthesis AND pathway","25058375","","","","","","","","","","","","","","","The article was not available but has been requested",""
+"Thyroid hormone synthesis","MAPK signaling pathway","MAPK AND Thyroid hormone synthesis AND pathway","25058375","","","","","","","","","","","","","","","The article was not available but has been requested",""
+"MAPK signaling pathway","Thyroid hormone synthesis","MAPK AND Thyroid hormone synthesis AND pathway","22889935","no","no","","","","","","","","","","","","","The full text was not read because the abstract said that MAPK didn't affect TSH",""
+"Thyroid hormone synthesis","MAPK signaling pathway","MAPK AND Thyroid hormone synthesis AND pathway","22889935","no","no","","","","","","","","","","","","","The full text was not read because the abstract said that MAPK didn't affect TSH",""
+"MAPK signaling pathway","Thyroid hormone synthesis","MAPK AND Thyroid hormone synthesis AND pathway","25411978","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","MAPK signaling pathway","MAPK AND Thyroid hormone synthesis AND pathway","25411978","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"MAPK signaling pathway","Thyroid hormone synthesis","MAPK AND Thyroid hormone synthesis AND pathway","24623499","","","","","","","","","","","","","","","The full text was not available but has been requested",""
+"Thyroid hormone synthesis","MAPK signaling pathway","MAPK AND Thyroid hormone synthesis AND pathway","24623499","","","","","","","","","","","","","","","The full text was not available but has been requested",""
+"Neurotrophin signaling pathway","Thyroid hormone synthesis","Neurotrophin AND Thyroid hormone synthesis AND pathway","16794016","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Neurotrophin signaling pathway","Neurotrophin AND Thyroid hormone synthesis AND pathway","16794016","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Neurotrophin signaling pathway","Thyroid hormone synthesis","Neurotrophin AND Thyroid hormone synthesis AND pathway","10401668","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Thyroid hormone synthesis","Neurotrophin signaling pathway","Neurotrophin AND Thyroid hormone synthesis AND pathway","10401668","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"NF-kappa B signaling pathway","Thyroid hormone synthesis","NF-kappa B AND Thyroid hormone synthesis AND crosstalk","20153803","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","NF-kappa B signaling pathway","NF-kappa B AND Thyroid hormone synthesis AND crosstalk","20153803","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"NF-kappa B signaling pathway","Thyroid hormone synthesis","NF-kappa B AND Thyroid hormone synthesis AND pathway","24044365","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","NF-kappa B signaling pathway","NF-kappa B AND Thyroid hormone synthesis AND pathway","24044365","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"NF-kappa B signaling pathway","Thyroid hormone synthesis","NF-kappa B AND Thyroid hormone synthesis AND pathway","24797634","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","NF-kappa B signaling pathway","NF-kappa B AND Thyroid hormone synthesis AND pathway","24797634","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"NF-kappa B signaling pathway","Thyroid hormone synthesis","NF-kappa B AND Thyroid hormone synthesis AND pathway","25748049","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","NF-kappa B signaling pathway","NF-kappa B AND Thyroid hormone synthesis AND pathway","25748049","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"NF-kappa B signaling pathway","Thyroid hormone synthesis","NF-kappa B AND Thyroid hormone synthesis AND pathway","25260367","no","no","","","","","","","","","","","","","The full text was not read because NF-kappa B was not mentioned in the abstract",""
+"Thyroid hormone synthesis","NF-kappa B signaling pathway","NF-kappa B AND Thyroid hormone synthesis AND pathway","25260367","no","no","","","","","","","","","","","","","The full text was not read because NF-kappa B was not mentioned in the abstract",""
+"Prolactin signaling pathway","Thyroid hormone synthesis","Prolactin AND Thyroid hormone synthesis AND crosstalk","26109800","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Prolactin signaling pathway","Prolactin AND Thyroid hormone synthesis AND crosstalk","26109800","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Prolactin signaling pathway","Thyroid hormone synthesis","Prolactin AND Thyroid hormone synthesis AND crosstalk","4858353","no","no","","","","","","","","","","","","","The paper suggested crosstalk but did not provide any clear explanation of the suggestion",""
+"Thyroid hormone synthesis","Prolactin signaling pathway","Prolactin AND Thyroid hormone synthesis AND crosstalk","4858353","no","no","","","","","","","","","","","","","The paper suggested crosstalk but did not provide any clear explanation of the suggestion",""
+"Prolactin signaling pathway","Thyroid hormone synthesis","Prolactin AND Thyroid hormone synthesis AND crosstalk","9405122","no","no","","","","","","","","","","","","","The full text was not read because the abstract says that there is not interactions between TSH and prolactin",""
+"Thyroid hormone synthesis","Prolactin signaling pathway","Prolactin AND Thyroid hormone synthesis AND crosstalk","9405122","no","no","","","","","","","","","","","","","The full text was not read because the abstract says that there is not interactions between TSH and prolactin",""
+"Prolactin signaling pathway","Thyroid hormone synthesis","Prolactin AND Thyroid hormone synthesis AND crosstalk","84758","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the relationship to each pathway with cancer, and not each other",""
+"Thyroid hormone synthesis","Prolactin signaling pathway","Prolactin AND Thyroid hormone synthesis AND crosstalk","84758","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned the relationship to each pathway with cancer, and not each other",""
+"Prolactin signaling pathway","Thyroid hormone synthesis","Prolactin AND Thyroid hormone synthesis AND crosstalk","6191178","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Prolactin signaling pathway","Prolactin AND Thyroid hormone synthesis AND crosstalk","6191178","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"TGF-beta signaling pathway","Thyroid hormone synthesis","TGF-beta AND Thyroid hormone synthesis AND pathway","23937304","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","TGF-beta signaling pathway","TGF-beta AND Thyroid hormone synthesis AND pathway","23937304","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"TGF-beta signaling pathway","Thyroid hormone synthesis","TGF-beta AND Thyroid hormone synthesis AND pathway","21874046","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract, only thyroid cancer",""
+"Thyroid hormone synthesis","TGF-beta signaling pathway","TGF-beta AND Thyroid hormone synthesis AND pathway","21874046","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract, only thyroid cancer",""
+"TGF-beta signaling pathway","Thyroid hormone synthesis","TGF-beta AND Thyroid hormone synthesis AND pathway","16037131","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","TGF-beta signaling pathway","TGF-beta AND Thyroid hormone synthesis AND pathway","16037131","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"TGF-beta signaling pathway","Thyroid hormone synthesis","TGF-beta AND Thyroid hormone synthesis AND pathway","21315800","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract, just thyroid cells",""
+"Thyroid hormone synthesis","TGF-beta signaling pathway","TGF-beta AND Thyroid hormone synthesis AND pathway","21315800","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract, just thyroid cells",""
+"TGF-beta signaling pathway","Thyroid hormone synthesis","TGF-beta AND Thyroid hormone synthesis AND pathway","15525600","no","no","","","","","","","","","","","","","There only seemed to be crosstalk in the other direction",""
+"Thyroid hormone synthesis","TGF-beta signaling pathway","TGF-beta AND Thyroid hormone synthesis AND pathway","15525600","yes","no","activating","T3","hormone","hormone","TGFB1","P01137","UNIPROT","Homo sapiens","hepatocyte","BTO:0000575","cancer","A previous report (Miller et al. 2001) and ours have demonstrated that treatment with T3 for 12 h or more induces TGF-β expression.","The paper describes a clear effect that T3 has on TGF-beta transcription",""
+"TNF signaling pathway","Thyroid hormone synthesis","TNF AND Thyroid hormone synthesis AND pathway ","22649286","no","no","","","","","","","","","","","","","The text suggested crosstalk, but did not provide any support",""
+"Thyroid hormone synthesis","TNF signaling pathway","TNF AND Thyroid hormone synthesis AND pathway","22649286","no","no","","","","","","","","","","","","","The text suggested crosstalk, but did not provide any support",""
+"TNF signaling pathway","Thyroid hormone synthesis","TNF AND Thyroid hormone synthesis AND pathway","18403482","no","no","","","","","","","","","","","","","The full text was not read because the abstract only seemed to suggest indirect interactions",""
+"Thyroid hormone synthesis","TNF signaling pathway","TNF AND Thyroid hormone synthesis AND pathway","18403482","no","no","","","","","","","","","","","","","The full text was not read because the abstract only seemed to suggest indirect interactions",""
+"TNF signaling pathway","Thyroid hormone synthesis","TNF AND Thyroid hormone synthesis AND pathway","8981225","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","TNF signaling pathway","TNF AND Thyroid hormone synthesis AND pathway","8981225","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"TNF signaling pathway","Thyroid hormone synthesis","TNF AND Thyroid hormone synthesis AND pathway","11741944","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","TNF signaling pathway","TNF AND Thyroid hormone synthesis AND pathway","11741944","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"TNF signaling pathway","Thyroid hormone synthesis","TNF AND Thyroid hormone synthesis AND pathway","9449644","no","no","","","","","","","","","","","","","The full text was not read because the abstract only described an indirect interaciton",""
+"Thyroid hormone synthesis","TNF signaling pathway","TNF AND Thyroid hormone synthesis AND pathway","9449644","no","no","","","","","","","","","","","","","The full text was not read because the abstract only described an indirect interaciton",""
+"Toll-like receptor signaling pathway","Thyroid hormone synthesis","Toll-like receptor AND Thyroid hormone synthesis AND pathway","22986642","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Toll-like receptor signaling pathway","Toll-like receptor AND Thyroid hormone synthesis AND pathway","22986642","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Toll-like receptor signaling pathway","Thyroid hormone synthesis","Toll-like receptor AND Thyroid hormone synthesis AND pathway","12237307","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Toll-like receptor signaling pathway","Toll-like receptor AND Thyroid hormone synthesis AND pathway","12237307","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Toll-like receptor signaling pathway","Thyroid hormone synthesis","Toll-like receptor AND Thyroid hormone synthesis AND pathway","19494260","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","Toll-like receptor signaling pathway","Toll-like receptor AND Thyroid hormone synthesis AND pathway","19494260","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"VEGF signaling pathway","Thyroid hormone synthesis","VEGF AND Thyroid hormone synthesis AND crosstalk","19879961","no","no","","","","","","","","","","","","","The full text was not read because the abstract only described indirect interactions",""
+"Thyroid hormone synthesis","VEGF signaling pathway","VEGF AND Thyroid hormone synthesis AND crosstalk","19879961","no","no","","","","","","","","","","","","","The full text was not read because the abstract only described indirect interactions",""
+"VEGF signaling pathway","Thyroid hormone synthesis","VEGF AND Thyroid hormone synthesis AND crosstalk","18080776","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned indirect interactions",""
+"Thyroid hormone synthesis","VEGF signaling pathway","VEGF AND Thyroid hormone synthesis AND crosstalk","18080776","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned indirect interactions",""
+"VEGF signaling pathway","Thyroid hormone synthesis","VEGF AND Thyroid hormone synthesis AND pathway","22681587","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Thyroid hormone synthesis","VEGF signaling pathway","VEGF AND Thyroid hormone synthesis AND pathway","22681587","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"VEGF signaling pathway","Thyroid hormone synthesis","VEGF AND Thyroid hormone synthesis AND pathway","18723843","no","no","","","","","","","","","","","","","The full text was not read because VEGF was not mentioned in the abstract",""
+"Thyroid hormone synthesis","VEGF signaling pathway","VEGF AND Thyroid hormone synthesis AND pathway","18723843","no","no","","","","","","","","","","","","","The full text was not read because VEGF was not mentioned in the abstract",""
+"VEGF signaling pathway","Thyroid hormone synthesis","VEGF AND Thyroid hormone synthesis AND pathway","24286160","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"Thyroid hormone synthesis","VEGF signaling pathway","VEGF AND Thyroid hormone synthesis AND pathway","24286160","no","no","","","","","","","","","","","","","The full text was not read because thyroid hormone synthesis was not mentioned in the abstract",""
+"NF-kappa B signaling pathway","Adherens junction","NF-kappa B AND Adherens AND pathway","24392129","no","","","","","","","","","","","","","","does not mention crosstalk",""
+"Adherens junction","NF-kappa B signaling pathway","NF-kappa B AND Adherens AND pathway","24392129","no","","","","","","","","","","","","","","does not mention crosstalk",""
+"NF-kappa B signaling pathway","Adherens junction","NF-kappa B AND Adherens AND pathway","24392129","no","","","","","","","","","","","","","","",""
+"Adherens junction","NF-kappa B signaling pathway","NF-kappa B AND Adherens AND pathway","24392129","yes","yes","inhibiting","CDH1","P12830","UNIPROT","","","","Homo sapiens","melanoma cell","BTO:0000848","cancer","Studies showed that the loss of E-cadherin and the loss of cadherin-mediated cell–cell contacts activated NF-κB signalling, while the overexpression of E-cadherin suppressed its activity.","This entry is a review paper, but cites 15378016",""
+"NF-kappa B signaling pathway","Adherens junction","NF-kappa B AND Adherens AND pathway","24392129","no","","","","","","","","","","","","","","",""
+"Adherens junction","NF-kappa B signaling pathway","NF-kappa B AND Adherens AND pathway","16699959","no","","","","","","","","","","","","","","",""
+"NF-kappa B signaling pathway","Adherens junction","NF-kappa B AND Adherens AND pathway","16699959","no","","","","","","","","","","","","","","",""
+"Notch signaling pathway","Prolactin signaling pathway","Prolactin AND Notch AND pathway","25592291","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned each pathway indirectly",""
+"Prolactin signaling pathway","Notch signaling pathway","Prolactin AND Notch AND pathway","25592291","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned each pathway indirectly",""
+"Notch signaling pathway","Prolactin signaling pathway","Prolactin AND Notch AND pathway","26085845","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Prolactin signaling pathway","Notch signaling pathway","Prolactin AND Notch AND pathway","26085845","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Notch signaling pathway","Prolactin signaling pathway","Prolactin AND Notch AND pathway","811331","no","no","","","","","","","","","","","","","The full text was not read because notch was not mentioned in the abstract",""
+"Prolactin signaling pathway","Notch signaling pathway","Prolactin AND Notch AND pathway","811331","no","no","","","","","","","","","","","","","The full text was not read because notch was not mentioned in the abstract",""
+"Notch signaling pathway","Prolactin signaling pathway","Prolactin AND Notch AND pathway","24348887","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Prolactin signaling pathway","Notch signaling pathway","Prolactin AND Notch AND pathway","24348887","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"VEGF signaling pathway","Notch signaling pathway","VEGF AND Notch AND crosstalk","24659637","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Notch signaling pathway","VEGF signaling pathway","VEGF AND Notch AND crosstalk","24659637","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"VEGF signaling pathway","Notch signaling pathway","VEGF AND Notch AND crosstalk","25322777","yes","no","unknown","KDR","P35968","UNIPROT","","","","Homo sapiens","coronary artery endothelial cell","BTO:0004096","normal","Gene knockdown experiments illustrated the critical requirement for Flk-1 in mediating the EtOH-induced Notch signaling and endothelial angiogenic response.","The paper isn't very descriptive about the nature and specifics of the crosstalk, but it seems clear that Flk-1 has a direct crosstalk with notch, and the paper states that there is crosstalk between the two,",""
+"Notch signaling pathway","VEGF signaling pathway","VEGF AND Notch AND crosstalk","25322777","no","no","","","","","","","","","","","","","The crosstalk only seemed to be in one direction",""
+"Estrogen signaling pathway","Apoptosis","Estrogen AND Apoptosis AND crosstalk","24189571","unclear","yes","activating","ESR2","Q92731","UNIPROT","TP53","P04637","UNIPROT","Homo sapiens","mammary gland","BTO:0000817","breast cancer","Knockdown of IGF-1R in MCF-7 cells using siRNA increases ERβ expression and the subsequently altered ERβ:ERα ratio may increase apoptosis via activation of tumour suppressor p53","The text doesn't provide a lot of detail, and I'm not sure whether the increased ERbeta:ERalpha ratio having an effect on apoptosis counts as crosstalk",""
+"Apoptosis","Estrogen signaling pathway","Estrogen AND Apoptosis AND crosstalk","24189571","no","no","","","","","","","","","","","","","There only seems to be suggested crosstalk in the other direction",""
+"Estrogen signaling pathway","Apoptosis","Estrogen AND Apoptosis AND crosstalk","26345254","unclear","unknown","unknown","ERBB2","P04626","UNIPROT","BCL2","P10415","UNIPROT","Homo sapiens","mammary gland","BTO:0000817","breast cancer","The Her2+ subtype showed an enrichment of the adaptor molecules of the extrinsic pathway (76% of the annotated adaptor molecules), with antiapoptotic gene Bcl-2 subexpressed, and prosurvival gene Bcl-XL overexpressed","The paper keeps saying there is crosstalk but doesn't provide any clear explanations as to what the crosstalk event actually is",""
+"Apoptosis","Estrogen signaling pathway","Estrogen AND Apoptosis AND crosstalk","26345254","no","no","unknown","","","","","","","","","","","","The paper is very confusing, but seems to only suggest crosstalk in the other direction",""
+"Estrogen signaling pathway","Apoptosis","Estrogen AND Apoptosis AND crosstalk","25833830","no","no","","","","","","","","","","","","","The paper suggested crosstalk but mostly discussed crosstalk with TGF-beta",""
+"Apoptosis","Estrogen signaling pathway","Estrogen AND Apoptosis AND crosstalk","25833830","no","no","","","","","","","","","","","","","The paper suggested crosstalk but mostly discussed crosstalk with TGF-beta",""
+"Estrogen signaling pathway","Apoptosis","Estrogen AND Apoptosis AND crosstalk","26052034","yes","no","activating","ESR1/ESR2","P03372/Q92731","UNIPROT","","","","Homo sapiens","breast cancer cell","BTO:0000150","breast cancer","The conformation of the liganded ER complex modulates decisions for early apoptosis or early antagonism of apoptosis and late apoptosis ","The paper wasn't very clear on the crosstalk, but it said many times that apoptosis is induced by estrogen, so the crosstalk is positive",""
+"Estrogen signaling pathway","Apoptosis","Estrogen AND Apoptosis AND crosstalk","26052034","yes","yes","activating","ESR1","P03372","UNIPROT","","","","Homo sapiens","breast cancer cell","BTO:0000150","breast cancer","A variety of apoptosis-related genes are activated by E2 and blocked by 4-OHT in estrogen-deprived cells","The crosstalk isn't very specific, but it seems clear that there is transcriptional crosstalk",""
+"Apoptosis","Estrogen signaling pathway","Estrogen AND Apoptosis AND crosstalk","26052034","no","no","","","","","","","","","","","","","The crosstalk was only in the other direction",""
+"Estrogen signaling pathway","Apoptosis","Estrogen AND Apoptosis AND crosstalk","27045680","no","no","","","","","","","","","","","","","The abstract suggested crosstalk, but the paper only discussed crosstalk with other things",""
+"Apoptosis","Estrogen signaling pathway","Estrogen AND Apoptosis AND crosstalk","27045680","no","no","","","","","","","","","","","","","The abstract suggested crosstalk, but the paper only discussed crosstalk with other things",""
+"Estrogen signaling pathway","Apoptosis","Estrogen AND Apoptosis AND crosstalk","26845172","no","no","","","","","","","","","","","","","The text only discussed the interactions of each pathway with a completely different protein",""
+"Apoptosis","Estrogen signaling pathway","Estrogen AND Apoptosis AND crosstalk","26845172","no","no","","","","","","","","","","","","","The text only discussed the interactions of each pathway with a completely different protein",""
+"Estrogen signaling pathway","Apoptosis","Estrogen AND Apoptosis AND crosstalk","21720253","no","no","","","","","","","","","","","","","The paper only discussed the interaction with each pathway and MAPK, not each other",""
+"Apoptosis","Estrogen signaling pathway","Estrogen AND Apoptosis AND crosstalk","21720253","no","no","","","","","","","","","","","","","The paper only discussed the interaction with each pathway and MAPK, not each other",""
+"Estrogen signaling pathway","Apoptosis","Estrogen AND Apoptosis AND crosstalk","22252523","no","no","","","","","","","","","","","","","The full text was not read because apoptosis was not mentioned in the abstract",""
+"Apoptosis","Estrogen signaling pathway","Estrogen AND Apoptosis AND crosstalk","22252523","no","no","","","","","","","","","","","","","The full text was not read because apoptosis was not mentioned in the abstract",""
+"Estrogen signaling pathway","Apoptosis","Estrogen AND Apoptosis AND crosstalk","26311719","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Apoptosis","Estrogen signaling pathway","Estrogen AND Apoptosis AND crosstalk","26311719","no","no","","","","","","","","","","","","","The full text was not read because the abstract did not suggest any crosstalk",""
+"Estrogen signaling pathway","Apoptosis","Estrogen AND Apoptosis AND crosstalk","20664923","no","no","","","","","","","","","","","","","The text only describes interactions between the two pathways and TNF, not each other",""
+"Apoptosis","Estrogen signaling pathway","Estrogen AND Apoptosis AND crosstalk","20664923","no","no","","","","","","","","","","","","","The text only describes interactions between the two pathways and TNF, not each other",""
+"GnRH signaling pathway","Apoptosis","GnRH AND Apoptosis AND crosstalk","22922893","no","no","","","","","","","","","","","","","The full text was not read because apoptosis was not mentioned in the abstract",""
+"Apoptosis","GnRH signaling pathway","GnRH AND Apoptosis AND crosstalk","22922893","no","no","","","","","","","","","","","","","The full text was not read because apoptosis was not mentioned in the abstract",""
+"GnRH signaling pathway","Apoptosis","GnRH AND Apoptosis AND crosstalk","26050562","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned each pathway interacting with thyroid hormone",""
+"Apoptosis","GnRH signaling pathway","GnRH AND Apoptosis AND crosstalk","26050562","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned each pathway interacting with thyroid hormone",""
+"GnRH signaling pathway","Apoptosis","GnRH AND Apoptosis AND pathway","25873389","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned each pathway interacting with histone deacetylases and not each other",""
+"Apoptosis","GnRH signaling pathway","GnRH AND Apoptosis AND pathway","25873389","no","no","","","","","","","","","","","","","The full text was not read because the abstract only mentioned each pathway interacting with histone deacetylases and not each other",""
+"GnRH signaling pathway","Apoptosis","GnRH AND Apoptosis AND pathway","26093349","no","no","","","","","","","","","","","","","The full text was not read because the abstract states that there was no change in apoptosis when activating GnRH",""
+"Apoptosis","GnRH signaling pathway","GnRH AND Apoptosis AND pathway","26093349","no","no","","","","","","","","","","","","","The full text was not read because the abstract states that there was no change in apoptosis when activating GnRH",""
+"GnRH signaling pathway","Apoptosis","GnRH AND Apoptosis AND pathway","22112812","yes","no","activating","[GNRH1/GNRH2]","[P01148/O43555]","UNIPROT","CASP3","P42574","UNIPROT","Homo sapiens","granulosa cell","BTO:0000542","normal","In conclusion, GnRH-I or -II induces apoptosis in our human granulosa cell models through caspase-3-dependent extrinsic pathway rather than Bcl-2 family-dependent intrinsic pathway and attenuates IGF-I actions through Ak","The paper clearly describes the effect that GnRH has on caspase-3 of the apoptosis pathway",""
+"GnRH signaling pathway","Apoptosis","GnRH AND Apoptosis AND pathway","22112812","yes","no","activating","Gnrh1","P07490","UNIPROT","Bcl2","P49950","UNIPROT","Rattus norvegicus","granulosa cell","BTO:0000542","normal","On the other hand, the apoptotic effects of GnRH agonist on rat granulosa cells involve some of the Bcl-2 family members and caspase-3","This paper shows that the crosstalk between GnRH and apoptosis is different in humans than in rats",""
+"Apoptosis","GnRH signaling pathway","GnRH AND Apoptosis AND pathway","22112812","no","no","","","","","","","","","","","","","The crosstalk was only in one direction",""
+"GnRH signaling pathway","Apoptosis","GnRH AND Apoptosis AND pathway","25811175","yes","no","inhibiting","GNRHR","P30968","UNIPROT","CASP3","P42574","UNIPROT","Homo sapiens","prostate gland","BTO:0001129","cancer","We found that degarelix treatment induces an increase of caspase 3/7 activation in all prostate cells analyzed","Degarilix is a GnRHR antagonist, so the treatment of the drug blocked the effects of GnRHR which activated apoptosis, so there must be a negative crosstalk",""
+"Apoptosis","GnRH signaling pathway","GnRH AND Apoptosis AND pathway","25811175","no","no","","","","","","","","","","","","","The crosstalk was only in one direction",""
+"GnRH signaling pathway","Apoptosis","GnRH AND Apoptosis AND pathway","26973595","no","no","","","","","","","","","","","","","The full text was not read because the abstract stated that there was no effect of GnRH on apoptosis",""
+"Apoptosis","GnRH signaling pathway","GnRH AND Apoptosis AND pathway","26973595","no","no","","","","","","","","","","","","","The full text was not read because the abstract stated that there was no effect of GnRH on apoptosis",""
+"Adherens junction","NF-kappa B signaling pathway","Adherens AND NF-kappa B AND pathway","19931545","no","","","","","","","","","","","","","","",""
+"NF-kappa B signaling pathway","Adherens junction","Adherens AND NF-kappa B AND pathway","19931545","no","","","","","","","","","","","","","","",""
+"Adherens junction","NF-kappa B signaling pathway","Adherens AND NF-kappa B AND pathway","18343708","yes","yes","activating","Ctnnb1","Q9WU82","UNIPROT","Nfkb1","Q63369","UNIPROT","Rattus norvegicus","hepatocyte","BTO:0000575","","","Transcriptional relationship between E-cadherin and NF-kB activation.","Our data indicate that E-cadherin disassembly and concomitant inactivation of glycogen synthase kinase-3beta result in nuclear factor kappaB-dependent induction of iNOS in hepatocytes."
+"NF-kappa B signaling pathway","Adherens junction","Adherens AND NF-kappa B AND pathway","18343708","no","","","","","","","","","","","","","","",""
+"Adherens junction","VEGF signaling pathway","Adherens AND VEGF AND pathway","26884340","no","no","unknown","","","","","","","","endothelial cell","BTO:0001176","","","This relationship does not qualify as crosstalk because increasing VE-cadherin expression does not upregulate or downregulate VEGF transcription factors. Instead, it is dissociation caused by the mechanical force applied to the VE-cadherin-VEGFR2 complex that ultimately induces transcription.","These results provide a pathway-specific mechanism for the enhanced permeability of hantavirus-infected endothelial cells and suggest that stabilizing VE-cadherin within adherens junctions is a primary target for regulating endothelial cell permeability during pathogenic hantavirus infection."
+"VEGF signaling pathway","Adherens junction","Adherens AND VEGF AND pathway","26884340","no","","","","","","","","","","","","","","",""
+"Adherens junction","VEGF signaling pathway","Adherens AND VEGF AND pathway","20463083","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Adherens junction","Adherens AND VEGF AND pathway","20463083","yes","no","unknown","KDR","P35968","UNIPROT","CDH5","P33151","UNIPROT","Homo sapiens","endothelial cell","BTO:0001176","pathogenic viral infection","Concomitant with the VEGFR2 hyperphosphorylation, VE-cadherin was internalized to intracellular vesicles within ANDV- or HTNV-, but not TULV-, infected endothelial cells. Addition of angiopoietin-1 (Ang-1) or sphingosine-1-phosphate (S1P) to ANDV- or HTNV-infected cells blocked VE-cadherin internalization in response to VEGF.","VEGF binding to VEGFR2 causes internalization of VE-cadherin (I presume to be due to disassociation of the VE-cadherin-VEGFR2 complex). It seems as though this internalization would have a negative effect on Adherens Junction signaling because it would decrease the number of membrane-associated molecules of VE-cadherin.",""
+"Adherens junction","VEGF signaling pathway","Adherens AND VEGF AND pathway","20463083","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Adherens junction","Adherens AND VEGF AND pathway","26674641","no","","","","","","","","","","","","","","VEGF may augment process but is not directly responsible for regulating endothelial permiability. ","HGF secreted by MSCs protects the endothelial barrier function; however, VEGF secreted by MSCs may synergize with HGF to stabilise endothelial cell barrier function."
+"Adherens junction","VEGF signaling pathway","Adherens AND VEGF AND pathway","26674641","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Adherens junction","Adherens AND VEGF AND pathway","23565059","no","","","","","","","","","","","","","","",""
+"Adherens junction","VEGF signaling pathway","Adherens AND VEGF AND pathway","23565059","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Adherens junction","Adherens AND VEGF AND pathway","24496925","no","","","","","","","","","","","","","","",""
+"Adherens junction","VEGF signaling pathway","Adherens AND VEGF AND pathway","24496925","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Adherens junction","Adherens AND VEGF AND pathway","21695048","yes","no","activating","KDR","F1MWF1","UNIPROT","CDH5","Q6URK6","UNIPROT","Bos taurus","retinal microvascular endothelial cell","BTO:0005001","PEDF treatment","PEDF acted by a) preventing dissociation of AJ and TJ proteins and b) regulating both the association of VEGF receptors with AJ proteins and the subsequent phosphorylation of the AJ proteins, VE-cadherin and β-catenin.","This crosstalk is γ-secretase-dependent: ""VEGF decreased γ-secretase association with VE-cadherin while PEDF prevented this and thus supports processing of VEGFRs as the critical positive regulator of AJ stabilization""",""
+"Adherens junction","VEGF signaling pathway","Adherens AND VEGF AND pathway","21695048","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Adherens junction","Adherens AND VEGF AND pathway","19633358","yes","no","activating","VEGFA","P15692","UNIPROT","RAC1","P63000","UNIPROT","Homo sapiens","pulmonary artery endothelial cell line","BTO:0003150","","Collectively, these data suggest that VEGF leads to a Rac-mediated generation of ROS, which, in turn, elevates the tyrosine phosphorylation of VE-cadherin and beta-catenin, ultimately regulating adherens junction integrity.","",""
+"Adherens junction","VEGF signaling pathway","Adherens AND VEGF AND pathway","19633358","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Adherens junction","Adherens AND VEGF AND pathway","20413783","yes","no","activating","RAP1A/RAP1B","P62834/P61224","UNIPROT","MLLT4","P55196","UNIPROT","Homo sapiens","HUVEC cell","BTO:0001949","cell line","Treatment of human umbilical vein endothelial cells (HUVECs) with vascular endothelial growth factor (VEGF) and sphingosine 1-phosphate (S1P) induced the activation of Rap1. Activated Rap1 regulated intracellular localization of afadin.","",""
+"Adherens junction","VEGF signaling pathway","Adherens AND VEGF AND pathway","20413783","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Adherens junction","Adherens AND VEGF AND pathway","27020249","no","","","","","","","","","","","","","","",""
+"Adherens junction","VEGF signaling pathway","Adherens AND VEGF AND pathway","27020249","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Adherens junction","Adherens AND VEGF AND pathway","27020249","no","","","","","","","","","","","","","","correlation; no evidence for crosstalk",""
+"Adherens junction","VEGF signaling pathway","Adherens AND VEGF AND pathway","19284967","no","","","","","","","","","","","","","","discusses tight junction",""
+"VEGF signaling pathway","Adherens junction","Adherens AND VEGF AND pathway","19284967","no","","","","","","","","","","","","","","discusses tight junction",""
+"Adherens junction","VEGF signaling pathway","Adherens AND VEGF AND pathway","18805433","no","","","","","","","","","","","","","","Study describes effects of anti-cancer drug but does not report novel instance of crosstalk.",""
+"VEGF signaling pathway","Adherens junction","Adherens AND VEGF AND pathway","18805433","no","","","","","","","","","","","","","","Study describes effects of anti-cancer drug but does not report novel instance of crosstalk.",""
+"Adherens junction","VEGF signaling pathway","Adherens AND VEGF AND pathway","21177802","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Adherens junction","Adherens AND VEGF AND pathway","21177802","no","","","","","","","","","","","","","","Study shows that inhibitors of VEGF proteins protect against ANDV-induced endothelial cell permeability but does not describe novel evidence of crosstalk.",""
+"Adherens junction","VEGF signaling pathway","Adherens AND VEGF AND pathway","15579907","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Adherens junction","Adherens AND VEGF AND pathway","15579907","no","","","","","","","","","","","","","","",""
+"Adherens junction","mTOR signaling pathway","Adherens AND mTOR AND pathway","25977367","no","","","","","","","","","","","","","","",""
+"mTOR signaling pathway","Adherens junction","Adherens AND mTOR AND pathway","25977367","no","","","","","","","","","","","","","","",""
+"Adherens junction","mTOR signaling pathway","Adherens AND mTOR AND pathway","22205374","no","","","","","","","","","","","","","","",""
+"mTOR signaling pathway","Adherens junction","Adherens AND mTOR AND pathway","22205374","no","","","","","","","","","","","","","","Mentions in background that mTOR signaling targets adherens junctions but not sure which paper it references.","Increased mTOR/S6K1 signaling regulates signaling pathways that target fibrosis through adherens junctions."
+"Adherens junction","mTOR signaling pathway","Adherens AND mTOR AND pathway","25600338","yes","yes","activating","CDH1","P12830","UNIPROT","MTOR","P42345","UNIPROT","Homo sapiens","osteoclast","BTO:0000968","cancer","We elucidate that hAJ activates the mTOR pathway in cancer cells, which drives the progression from single cells to micrometastases.","looked for transcriptional indicators of mTOR activity",""
+"Adherens junction","mTOR signaling pathway","Adherens AND mTOR AND pathway","25600338","yes","yes","activating","CDH1","P12830","UNIPROT","MTOR","P42345","UNIPROT","Homo sapiens","MDA-MB-231 cell","BTO:0000815","cancer","We elucidate that hAJ activates the mTOR pathway in cancer cells, which drives the progression from single cells to micrometastases.","looked for transcriptional indicators of mTOR activity",""
+"mTOR signaling pathway","Adherens junction","Adherens AND mTOR AND pathway","25600338","no","","","","","","","","","","","","","","other direction",""
+"Adherens junction","mTOR signaling pathway","Adherens AND mTOR AND pathway","25470785","no","","","","","","","","","","","","","","",""
+"mTOR signaling pathway","Adherens junction","Adherens AND mTOR AND pathway","25470785","no","","","","","","","","","","","","","","",""
+"Adherens junction","mTOR signaling pathway","Adherens AND mTOR AND pathway","18990449","no","","","","","","","","","","","","","","",""
+"mTOR signaling pathway","Adherens junction","Adherens AND mTOR AND pathway","18990449","yes","yes","activating","MTOR","P42345","UNIPROT","CDH5","P33151","UNIPROT","Homo sapiens","HUVEC cell","BTO:0001949","","Herewith, we demonstrated that the expression of VE-cadherin is dependent on mTOR and PI3K signaling.","",""
+"Adherens junction","mTOR signaling pathway","Adherens AND mTOR AND pathway","18990449","no","","","","","","","","","","","","","","",""
+"mTOR signaling pathway","Adherens junction","Adherens AND mTOR AND pathway","17178688","no","","","","","","","","","","","","","","",""
+"Adherens junction","mTOR signaling pathway","Adherens AND mTOR AND pathway","17178688","no","","","","","","","","","","","","","","",""
+"Adherens junction","Apoptosis","Adherens AND Apoptosis AND pathway","26243458","no","","","","","","","","","","","","","","",""
+"Apoptosis","Adherens junction","Adherens AND Apoptosis AND pathway","26243458","no","","","","","","","","","","","","","","",""
+"Adherens junction","Apoptosis","Adherens AND Apoptosis AND pathway","23375756","no","","","","","","","","","","","","","","",""
+"Apoptosis","Adherens junction","Adherens AND Apoptosis AND pathway","23375756","yes","no","inhibiting","Casp3","P55213","UNIPROT","Ctnnb1","Q9WU82","UNIPROT","Rattus norvegicus","lung microvascular endothelial cell","BTO:0005738","cancer","Our study shows that TRAIL-induced microvascular hyperpermeability is PI3K dependent and may be mediated by caspase-3 cleavage of the endothelial cell adherens junctional complex.","disruption of adherens junctional complex is PI3K dependent",""
+"Adherens junction","ErbB signaling pathway","Adherens AND ErbB AND pathway","22457761","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Adherens junction","Adherens AND ErbB AND pathway","22457761","no","","","","","","","","","","","","","","Study discusses beta-catenin loss more in the context of Wnt signaling.",""
+"Adherens junction","ErbB signaling pathway","Adherens AND ErbB AND pathway","21531776","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Adherens junction","ErbB AND Adherens AND pathway","9093016","no","","","","","","","","","","","","","","","Interestingly, these junctions in the corneal epithelium also contain paxillin, a focal adhesion associated phosphoprotein which is a target of pp125 focal adhesion kinase, erbB-2 kinase and p21Obcr/abl oncogene."
+"Adherens junction","ErbB signaling pathway","ErbB AND Adherens AND pathway","9093016","no","","","","","","","","","","","","","","","Interestingly, these junctions in the corneal epithelium also contain paxillin, a focal adhesion associated phosphoprotein which is a target of pp125 focal adhesion kinase, erbB-2 kinase and p21Obcr/abl oncogene."
+"ErbB signaling pathway","Adherens junction","ErbB AND Adherens AND pathway","18952113","no","","","","","","","","","","","","","","",""
+"Adherens junction","ErbB signaling pathway","ErbB AND Adherens AND pathway","18952113","no","","","","","","","","","","","","","","Thrombospondin (TSP1) not part of Adherens signaling pathway.",""
+"ErbB signaling pathway","Adherens junction","ErbB AND Adherens AND pathway","18266961","no","","","","","","","","","","","","","","gamma-secretase is heavily involved in angiogenesis and does affect both Adherens junctions and ErbB signaling",""
+"Adherens junction","ErbB signaling pathway","ErbB AND Adherens AND pathway","18266961","no","","","","","","","","","","","","","","gamma-secretase is heavily involved in angiogenesis and does affect both Adherens junctions and ErbB signaling",""
+"Adherens junction","Estrogen signaling pathway","Adherens AND Estrogen AND pathway","23737770","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Adherens junction","Adherens AND Estrogen AND pathway","23737770","no","","","","","","","","","","","","","","OP decreases connexin, N-cadherin in vole testes. Authors speculate there is an ER-mediated mechanism, but the mechanism remains unclear.",""
+"Adherens junction","Estrogen signaling pathway","Adherens AND Estrogen AND pathway","22546564","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Adherens junction","Adherens AND Estrogen AND pathway","22546564","no","","","","","","","","","","","","","","",""
+"Adherens junction","Estrogen signaling pathway","Adherens AND Estrogen AND pathway","22457761","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Adherens junction","Adherens AND Estrogen AND pathway","22457761","no","","","","","","","","","","","","","","",""
+"Adherens junction","Estrogen signaling pathway","Adherens AND Estrogen AND pathway","21051859","yes","yes","inhibiting","SNAI1","O95863","UNIPROT","ESR1","P03372","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","breast cancer","A mechanism which essentially segregates EMT from the proliferative region of these ER-positive tumours was discovered by Fujita et al. [2003], who were the first to make the key observation that the absence of MTA3 (oestrogen-dependent component of the Mi-2/NuRd co-repressor) or of ER leads to the up-regulation of Snail1 and the subsequent loss of E-cadherin, and that MTA3 directly repressed Snail1. They  went on to show that MTA3 expression requires ER and oestrogen [Fujita et al., 2004]. Following this finding, the inverse relationship was discovered: Snail1 represses ER [Dhasarathy et al., 2007].","cites 17761946",""
+"Estrogen signaling pathway","Adherens junction","Adherens AND Estrogen AND pathway","21051859","yes","yes","activating","MTA3","Q9BTC8","UNIPROT","CDH1","P12830","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","breast cancer","A mechanism which essentially segregates EMT from the proliferative region of these ER-positive tumours was discovered by Fujita et al. [2003], who were the first to make the key observation that the absence of MTA3 (oestrogen-dependent component of the Mi-2/NuRd co-repressor) or of ER leads to the up-regulation of Snail1 and the subsequent loss of E-cadherin, and that MTA3 directly repressed Snail1. They  went on to show that MTA3 expression requires ER and oestrogen [Fujita et al., 2004]. Following this finding, the inverse relationship was discovered: Snail1 represses ER [Dhasarathy et al., 2007].","cites 17761946; absence of MTA3 means loss of E-cadherin",""
+"Adherens junction","Estrogen signaling pathway","Adherens AND Estrogen AND pathway","25482622","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Adherens junction","Adherens AND Estrogen AND pathway","25482622","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","Adherens junction","Insulin AND Adherens AND pathway","27020249","no","","","","","","","","","","","","","","",""
+"Adherens junction","Insulin signaling pathway","Insulin AND Adherens AND pathway","27020249","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","Adherens junction","Insulin AND Adherens AND pathway","25751637","no","","","","","","","","","","","","","","",""
+"Adherens junction","Insulin signaling pathway","Insulin AND Adherens AND pathway","25751637","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","Adherens junction","Insulin AND Adherens AND pathway","24645679","no","","","","","","","","","","","","","","",""
+"Adherens junction","Insulin signaling pathway","Insulin AND Adherens AND pathway","24645679","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","Adherens junction","Insulin AND Adherens AND pathway","22924026","no","","","","","","","","","","","","","","",""
+"Adherens junction","Insulin signaling pathway","Insulin AND Adherens AND pathway","22924026","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","Adherens junction","Insulin AND Adherens AND pathway","18793745","no","","","","","","","","","","","","","","",""
+"Adherens junction","Insulin signaling pathway","Insulin AND Adherens AND pathway","18793745","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","Adherens junction","Insulin AND Adherens AND pathway","12356918","no","","","","","","","","","","","","","","",""
+"Adherens junction","Insulin signaling pathway","Insulin AND Adherens AND pathway","12356918","no","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","Adherens junction","Hippo AND Adherens AND pathway","12356918","no","","","","","","","","","","","","","","Hippo affects actin structure which then impacts E-cadherin regulation, but not direct crosstalk.","Mechanistically, we found that YAP promoted contractile actin structure formation by upregulating non-muscle myosin light chain expression and cellular ATP generation."
+"Adherens junction","Hippo signaling pathway","Hippo AND Adherens AND pathway","12356918","no","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","Adherens junction","Hippo AND Adherens AND pathway","26451343","no","","","","","","","","","","","","","","more associated with TJs",""
+"Adherens junction","Hippo signaling pathway","Hippo AND Adherens AND pathway","26451343","no","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","Adherens junction","Hippo AND Adherens AND pathway","26317911","no","","","","","","","","","","","","","","ethanol affects both pathways",""
+"Adherens junction","Hippo signaling pathway","Hippo AND Adherens AND pathway","26317911","no","","","","","","","","","","","","","","ethanol affects both pathways",""
+"Hippo signaling pathway","Adherens junction","Hippo AND Adherens AND pathway","24532814","no","","","","","","","","","","","","","","",""
+"Adherens junction","Hippo signaling pathway","Hippo AND Adherens AND pathway","24532814","yes","no","activating","CDH1","P12830","UNIPROT","YAP1","P46937","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","","Adherens junctions and the cadherin-catenin complex have been found to activate the Hippo signaling pathway and inhibit cell growth","cites 21730131:  E-cadherin-mediated cell-cell contact directly regulates the Hippo signaling pathway to control cell proliferation.",""
+"Hippo signaling pathway","Adherens junction","Hippo AND Adherens AND pathway","24532814","no","","","","","","","","","","","","","","",""
+"Adherens junction","Hippo signaling pathway","Hippo AND Adherens AND pathway","19531586","no","","","","","","","","","","","","","","Hpo impacts apical size, but no clear crosstalk reported.",""
+"Jak-STAT signaling pathway","Adherens junction","Jak-STAT AND Adherens AND crosstalk","25702679","no","","","","","","","","","","","","","","different definition of crosstalk",""
+"Adherens junction","Jak-STAT signaling pathway","Jak-STAT AND Adherens AND crosstalk","25702679","no","","","","","","","","","","","","","","different definition of crosstalk",""
+"Jak-STAT signaling pathway","Adherens junction","Jak-STAT AND Adherens AND crosstalk","24853279","no","","","","","","","","","","","","","","",""
+"Adherens junction","Jak-STAT signaling pathway","Jak-STAT AND Adherens AND crosstalk","24853279","no","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","Adherens junction","Jak-STAT AND Adherens AND crosstalk","19736564","no","","","","","","","","","","","","","","",""
+"Adherens junction","Jak-STAT signaling pathway","Jak-STAT AND Adherens AND crosstalk","19736564","no","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","Adherens junction","Jak-STAT AND Adherens AND crosstalk","24346697","no","","","","","","","","","","","","","","",""
+"Adherens junction","Jak-STAT signaling pathway","Jak-STAT AND Adherens AND crosstalk","24346697","no","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","Adherens junction","Jak-STAT AND Adherens AND crosstalk","15530849","yes","no","activating","Jak2","Q62689","UNIPROT","Cdh1","Q9R0T4","UNIPROT","Rattus norvegicus","intestinal epithelium","BTO:0000781","","Indeed, the modifications in localization of adherens junctions proteins and the migration, observed in gastrin-stimulated cells, were reversed by inhibition of both kinases.","",""
+"Adherens junction","Jak-STAT signaling pathway","Jak-STAT AND Adherens AND crosstalk","15530849","no","","","","","","","","","","","","","","",""
+"Notch signaling pathway","Adherens junction","Notch AND Adherens AND pathway","23970418","no","","","","","","","","","","","","","","colocalization of Notch and Canoe at AJs, but no clear crosstalk",""
+"Adherens junction","Notch signaling pathway","Notch AND Adherens AND pathway","23970418","no","","","","","","","","","","","","","","colocalization of Notch and Canoe at AJs, but no clear crosstalk",""
+"Notch signaling pathway","Adherens junction","Notch AND Adherens AND pathway","23250217","unclear","","","","","","","","","","","","","","fat mutants and cells with Notch overexpression have similar AJ defects, but not sure of the connection between the two pathways.","Together, these results demonstrate that Notch activation disrupts cell shape, junctional localization and microtubule organization in the denticle field, producing defects with striking similarities to the defects in fat mutants."
+"Adherens junction","Notch signaling pathway","Notch AND Adherens AND pathway","23250217","no","","","","","","","","","","","","","","",""
+"Notch signaling pathway","Adherens junction","Notch AND Adherens AND pathway","17420294","yes","unknown","activating","fng","Q24342","UNIPROT","shg","Q24298","UNIPROT","Drosophila melanogaster","main body follicular cells, stretched cells","","","Together, my results demonstrate that the Notch pathway controls AJ remodeling between the StCs and that this role is crucial for the timing of MBFC displacement and StC flattening.","",""
+"Adherens junction","Notch signaling pathway","Notch AND Adherens AND pathway","17420294","no","","","","","","","","","","","","","","",""
+"Notch signaling pathway","Adherens junction","Notch AND Adherens AND pathway","9223106","no","","","","","","","","","","","","","","",""
+"Adherens junction","Notch signaling pathway","Notch AND Adherens AND pathway","9223106","no","","","","","","","","","","","","","","",""
+"Notch signaling pathway","Adherens junction","Notch AND Adherens AND pathway","16049109","yes","no","activating","N","P07207","UNIPROT","Act5C","P10987","UNIPROT","Drosophila melanogaster","wing","BTO:0001463","","Genetic manipulation establishes that a stripe of Notch activation is both necessary and sufficient for this DV boundary cell phenotype, and supports the existence of a non-transcriptional branch of the Notch pathway that influences F-actin.","",""
+"Adherens junction","Notch signaling pathway","Notch AND Adherens AND pathway","16049109","no","","","","","","","","","","","","","","",""
+"Adherens junction","TGF-beta signaling pathway","Adherens AND TGF-beta AND pathway","26345253","no","","","","","","","","","","","","","","AJ reinforcement by upregulation of cadherin-11 following mitral valve prolapse causes tension and ECM remodeling. It sounds like the authors are stating the upregulation of TGF-B1 is due to these effects rather than protein-protein interactions between AJ and TGF-B proteins.","AJ reinforcement might promote latent TGF-β1 activation leading to extracellular matrix remodeling in floppy MV."
+"TGF-beta signaling pathway","Adherens junction","Adherens AND TGF-beta AND pathway","26345253","no","","","","","","","","","","","","","","",""
+"Adherens junction","TGF-beta signaling pathway","Adherens AND TGF-beta AND pathway","26113040","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Adherens junction","Adherens AND TGF-beta AND pathway","26113040","yes","no","inhibiting","Tgfb3","Q07258","UNIPROT","Cdh1","Q9R0T4","UNIPROT","Rattus norvegicus","mammary epithelial cell","BTO:0004300","involution","Following TGF-β3 treatment, EpH4 monolayers displayed decreased E-cad junctional staining and increased cytoplasmic localization, as well as increased E-cad cleavage (Figures 3l and m). In addition, gene expression analysis revealed downregulation of multiple claudins, classical cadherns and cell adhesion molecules with TGF-β3 treatment (Table 1), demonstrating global changes in cell junctions with acquisition of the phagocytic phenotype.","",""
+"Adherens junction","TGF-beta signaling pathway","Adherens AND TGF-beta AND pathway","25767275","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Adherens junction","Adherens AND TGF-beta AND pathway","25767275","yes","yes","inhibiting","[MAPK11/MAPK14]","[Q15759/Q16539]","UNIPROT","CDH11/CDH2","P55287/P19022","UNIPROT","Homo sapiens","smooth muscle cell","BTO:0004576","","Cell-cell adhesion and adherens junction elongation were associated with reduced transforming growth factor-β signaling, and exogenous transforming growth factor-β1 suppressed junction elongation via the noncanonical p38 pathway.","",""
+"Adherens junction","TGF-beta signaling pathway","Adherens AND TGF-beta AND pathway","25681395","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Adherens junction","Adherens AND TGF-beta AND pathway","25681395","unclear","","","","","","","","","","","","","","Seems as though TGF-B signaling acts through Notch to cause AJ remodeling.",""
+"Adherens junction","TGF-beta signaling pathway","Adherens AND TGF-beta AND pathway","22696062","yes","yes","inhibiting","CDH3","P22223","UNIPROT","TGFB2","P61812","UNIPROT","Homo sapiens","hair follicle","BTO:0000554","","P-cadherin silencing reduced the expression of the anagen-promoting growth factor, IGF-1, whereas that of transforming growth factor β 2 (TGFβ2; catagen promoter) was enhanced.","",""
+"TGF-beta signaling pathway","Adherens junction","Adherens AND TGF-beta AND pathway","22696062","no","","","","","","","","","","","","","","",""
+"Adherens junction","TNF signaling pathway","Adherens AND TNF AND pathway","25065623","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Adherens junction","Adherens AND TNF AND pathway","25065623","no","","","","","","","","","","","","","","",""
+"Adherens junction","TNF signaling pathway","Adherens AND TNF AND pathway","20933214","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Adherens junction","Adherens AND TNF AND pathway","20933214","yes","unknown","inhibiting","Casp3","P55213","UNIPROT","Ctnnb1","Q9WU82","UNIPROT","Rattus norvegicus","lung microvascular endothelial cell","BTO:0005738","","The pretreatment with Z-DEVD-FMK (100 μM) attenuated TNF-α-induced (10 ng/ml) disruption of the adherens junctions, actin stress fiber formation, increased caspase-3 activity,","",""
+"Adherens junction","TNF signaling pathway","Adherens AND TNF AND pathway","20933214","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Adherens junction","Adherens AND TNF AND pathway","18762254","no","","","","","","","","","","","","","","",""
+"Adherens junction","TNF signaling pathway","Adherens AND TNF AND pathway","18762254","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Adherens junction","Adherens AND TNF AND pathway","12219009","yes","unknown","inhibiting","TNF","P01375","UNIPROT","SRC","P12931","UNIPROT","Homo sapiens","HUVEC cell","BTO:0001949","","TNF causes tyrosine phosphorylation of VE cadherin","phosphorylation of VE cadherin causes AJ disruption and increased permeability",""
+"Adherens junction","TNF signaling pathway","Adherens AND TNF AND pathway","12219009","no","","","","","","","","","","","","","","",""
+"Adherens junction","Wnt signaling pathway","Adherens AND Wnt AND pathway","25578635","no","","","","","","","","","","","","","","Computationally predict that EGR-1 facilitates communication between Wnt and AJ signaling. ""However, in vivo and clinical experiments are still needed to confirm our hypothesis.""",""
+"Wnt signaling pathway","Adherens junction","Adherens AND Wnt AND pathway","25578635","no","","","","","","","","","","","","","","",""
+"Adherens junction","Wnt signaling pathway","Adherens AND Wnt AND pathway","21703193","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Adherens junction","Adherens AND Wnt AND pathway","21703193","no","","","","","","","","","","","","","","",""
+"Adherens junction","Wnt signaling pathway","Adherens AND Wnt AND pathway","27082441","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Adherens junction","Adherens AND Wnt AND pathway","27082441","no","","","","","","","","","","","","","","",""
+"Adherens junction","Wnt signaling pathway","Adherens AND Wnt AND pathway","26957367","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Adherens junction","Adherens AND Wnt AND pathway","26957367","yes","yes","activating","Ctnnb1","Q02248","UNIPROT","Cdh1","P09803","UNIPROT","Mus musculus","ameloblast","BTO:0001663","","We further demonstrated that migration of ALCs was inhibited in vitro and that E-cadherin expression was significantly up-regulated when ALCs were treated with the β-catenin inhibitor, ICG-001.","",""
+"Adherens junction","Hippo signaling pathway","Adherens AND Wnt AND pathway","25290150","no","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","Adherens junction","Adherens AND Wnt AND pathway","25290150","no","","","","","","","","","","","","","","",""
+"Adherens junction","Wnt signaling pathway","Adherens AND Wnt AND pathway","25290150","","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Adherens junction","Adherens AND Wnt AND pathway","25290150","no","","","","","","","","","","","","","","",""
+"Adherens junction","Wnt signaling pathway","Adherens AND Wnt AND pathway","25355426","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Adherens junction","Adherens AND Wnt AND pathway","25355426","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Adherens junction","Adherens AND Wnt AND pathway","26402535","yes","no","inhibiting","Gsk3b","P18266","UNIPROT","Ctnnb1","Q9WU82","UNIPROT","Rattus norvegicus","lung microvascular endothelial cell","BTO:0005738","","Inhibiting phosphorylation of β-catenin and caspase 3 activity using glycogen synthase kinase 3-specific inhibitor SB216763 help regulates HS-induced microvascular hyperpermeability.","",""
+"Adherens junction","Wnt signaling pathway","Adherens AND Wnt AND pathway","26402535","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Adherens junction","Adherens AND Wnt AND pathway","24860869","no","","","","","","","","","","","","","","",""
+"Adherens junction","Wnt signaling pathway","Adherens AND Wnt AND pathway","24860869","unclear","","","","","","","","","","","","","","It is unlcear whether AJ proteins are causing the observed Wnt pathway activation, or if it is a parallel process in differentiation.",""
+"Adherens junction","ErbB signaling pathway","Adherens AND Wnt AND pathway","21939503","yes","yes","inhibiting","CDH1","P12830","UNIPROT","EGFR","P00533","UNIPROT","Homo sapiens","squamous cell carcinoma cell","BTO:0001289","cancer cell lines","Our results suggest for the first time that reduction of E-cad results in upregulation of EGFR transcriptionally.","",""
+"ErbB signaling pathway","Adherens junction","Adherens AND Wnt AND pathway","21939503","no","","","","","","","","","","","","","","",""
+"Adherens junction","Wnt signaling pathway","Adherens AND Wnt AND pathway","21909376","yes","yes","activating","CDH1","F1PAA9","UNIPROT","CTNNB1","B6V8E6","UNIPROT","Canis familiaris","renal epithelial cell","BTO:0005545","hepatocyte growth factor (HGF) treatment of MDCK cells, and gastrulation in embryonic development","This suggests that cadherins play a crucial role in β-catenin-dependent transcription.","Generally accepted that E-cadherin is a negative regulator of Wnt signaling as it binds cytoplasmic beta-catenin (not transcriptional).",""
+"Wnt signaling pathway","Adherens junction","Adherens AND Wnt AND pathway","21909376","no","","","","","","","","","","","","","","",""
+"Adherens junction","Wnt signaling pathway","Adherens AND Wnt AND pathway","25164084","yes","no","inhibiting","","","","","","","","","","","In most cases, restoration or overexpression of E-cadherin inhibited β-catenin activity by sequestering cytoplasmic β-catenin...","Commonly accepted; many papers would provide this evidence in a number of species and tissues.",""
+"Adherens junction","Toll-like receptor signaling pathway","Adherens AND Toll-like receptor AND pathway","25427801","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","Adherens junction","Adherens AND Toll-like receptor AND pathway","25427801","yes","yes","inhibiting","Tl","P08953","UNIPROT","shg","Q24298","UNIPROT","Drosophila melanogaster","embryo","BTO:0000379","development","In the absence of Toll or Dif and dorsal (dl), both E-cadherin down-regulation and actin-cable formation fail, thus resulting in open epidermal gaps.","",""
+"Adherens junction","Toll-like receptor signaling pathway","Adherens AND Toll-like receptor AND pathway","25065623","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","Adherens junction","Adherens AND Toll-like receptor AND pathway","25065623","no","","","","","","","","","","","","","","","Our results demonstrate that a direct chemical communication between the intestinal symbionts and PXR regulates mucosal integrity through a pathway that involves luminal sensing and signaling by TLR4."
+"Adherens junction","Toll-like receptor signaling pathway","Adherens AND Toll-like receptor AND pathway","24365204","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","Adherens junction","Adherens AND Toll-like receptor AND pathway","24365204","no","","","","","","","","","","","","","","",""
+"Adherens junction","Toll-like receptor signaling pathway","Adherens AND Toll-like receptor AND pathway","22155623","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","Adherens junction","Adherens AND Toll-like receptor AND pathway","22155623","no","","","","","","","","","","","","","","",""
+"Adherens junction","Toll-like receptor signaling pathway","Adherens AND Toll-like receptor AND pathway","21825064","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","Adherens junction","Adherens AND Toll-like receptor AND pathway","21825064","yes","no","inhibiting","TLR2","O60603","UNIPROT","CDH1","P12830","UNIPROT","Homo sapiens","MKN-45 cell","BTO:0001225","gastric cancer","Stimulation of MKN45 cells with the toll-like receptor 2 (TLR2) ligand P3C activated calpain and disrupted E-cadherin and β-catenin in a pattern similar to that induced by H. pylori.","",""
+"Adherens junction","Toll-like receptor signaling pathway","Adherens AND Toll-like receptor AND pathway","18326860","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","Adherens junction","Adherens AND Toll-like receptor AND pathway","18326860","unclear","no","inhibiting","TLR4","O00206","UNIPROT","SRC","P12931","UNIPROT","Homo sapiens","lung microvascular endothelial cell","BTO:0005738","","These data indicate that LPS recognition by TLR4 activates the SFKs, c-SRC, FYN, and YES, which, in turn, contribute to tyrosine phosphorylation of zonula adherens proteins to open the endothelial paracellular pathway.","",""
+"Adipocytokine signaling pathway","TGF-beta signaling pathway","Adipocytokine AND TGF-beta AND pathway","26808997","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Adipocytokine signaling pathway","Adipocytokine AND TGF-beta AND pathway","26808997","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","TGF-beta signaling pathway","Adipocytokine AND TGF-beta AND pathway","26017929","yes","unknown","activating","Lep","P50596","UNIPROT","Tgfb1/Tgfb2","P17246/Q07257","UNIPROT","Rattus norvegicus","intestinal epithelium","BTO:0000781","","Pre-treatment with rapamycin significantly inhibited leptin effects in LD formation, COX-2 and TGF-β production in IEC-6 cells.","",""
+"TGF-beta signaling pathway","Adipocytokine signaling pathway","Adipocytokine AND TGF-beta AND pathway","26017929","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","TGF-beta signaling pathway","Adipocytokine AND TGF-beta AND pathway","24757673","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Adipocytokine signaling pathway","Adipocytokine AND TGF-beta AND pathway","24757673","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","TGF-beta signaling pathway","Adipocytokine AND TGF-beta AND pathway","24335170","yes","yes","activating","NAMPT","P43490","UNIPROT","TGFB1","P01137","UNIPROT","Homo sapiens","HK-2 cell","BTO:0003575",""," Visfatin increased TGF-β secretion and the pattern of change for connexins expression was mimicked by exogenous application of TGF-β1. ","",""
+"TGF-beta signaling pathway","Adipocytokine signaling pathway","Adipocytokine AND TGF-beta AND pathway","24335170","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","TGF-beta signaling pathway","Adipocytokine AND TGF-beta AND pathway","22665633","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Adipocytokine signaling pathway","Adipocytokine AND TGF-beta AND pathway","22665633","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","TGF-beta signaling pathway","Adipocytokine AND TGF-beta AND pathway","23876795","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Adipocytokine signaling pathway","Adipocytokine AND TGF-beta AND pathway","23876795","unclear","","","","","","","","","","","","","At the 4h time point, TLR agonist synergy influenced pathways included Adipocytokine signaling pathway, cell cycle, calcium signaling pathway, NOD-like receptor signaling pathway and RIG-I-like receptor signaling pathway.","",""
+"ErbB signaling pathway","GnRH signaling pathway","ErbB AND GnRH AND crosstalk","22922893","no","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","ErbB signaling pathway","ErbB AND GnRH AND crosstalk","22922893","yes","no","inhibiting","[GNRH1/GNRH2]","[P01148/O43555]","UNIPROT","EGFR","P00533","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","4-hydroxy-tamoxifen (OHT)‑resistant","All cell lines showed expression of receptors for gonadotropin-releasing hormone (GnRH) I and II, and analogs of GnRH-I/II restored OHT sensitivity in both resistant cell lines by inhibition of erbB and AKT signalling.","",""
+"ErbB signaling pathway","HIF-1 signaling pathway","ErbB AND HIF-1 AND pathway","25596742","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","ErbB signaling pathway","ErbB AND HIF-1 AND pathway","25596742","yes","no","activating","HIF1A","Q16665","UNIPROT","ERBB2","P04626","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","","HIF-1 is both required and sufficient to induce lapatinib resistance as overexpression of stable HIF-1 in ERBB2-expressing cells blocks lapatinib-mediated effects and maintains ERBB2-downstream signaling under normoxic conditions.","",""
+"ErbB signaling pathway","HIF-1 signaling pathway","ErbB AND HIF-1 AND pathway","24472707","no","","","","","","","","","","","","","","HER2 (which is a part of ErbB pathway) regulates HIF-1a expression but through PI3K/Akt/mTOR pathway, not ErbB signaling.","HIF-1α expression in AI-resistant cells is likely regulated by HER2 activated-phosphatidylinositide-3-kinase/Akt-protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway, as its expression was inhibited by HER2 inhibitors and kinase pathway inhibitors."
+"HIF-1 signaling pathway","ErbB signaling pathway","ErbB AND HIF-1 AND pathway","24472707","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","HIF-1 signaling pathway","ErbB AND HIF-1 AND pathway","25451255","no","","","","","","","","","","","","","","Effects on HIF-1a accumulation do not occur with the wild type ErbB3.","Although, the sErbB3 wild type has approximately 25–50% suppressive effects of the sErbB3 mutant on the ErbB3–Akt signaling induced by heregulin β1 [11] (Fig. 1A), this suppressive effect failed to affect the nuclear accumulation of HIF-1α (Fig. 1B) and Nrf2"
+"HIF-1 signaling pathway","ErbB signaling pathway","ErbB AND HIF-1 AND pathway","24522376","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","HIF-1 signaling pathway","ErbB AND HIF-1 AND pathway","24522376","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","ErbB signaling pathway","ErbB AND HIF-1 AND pathway","22215620","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","HIF-1 signaling pathway","ErbB AND HIF-1 AND pathway","22215620","no","","","","","","","","","","","","","","",""
+"Apoptosis","HIF-1 signaling pathway","Apoptosis AND HIF-1 AND crosstalk","25108166","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","Apoptosis","Apoptosis AND HIF-1 AND crosstalk","25108166","no","","","","","","","","","","","","","","",""
+"Apoptosis","HIF-1 signaling pathway","Apoptosis AND HIF-1 AND crosstalk","27210058","no","","","","","","","","","","","","","","does not mention interplay between pathways",""
+"HIF-1 signaling pathway","Apoptosis","Apoptosis AND HIF-1 AND crosstalk","27210058","no","","","","","","","","","","","","","","does not mention interplay between pathways",""
+"Apoptosis","HIF-1 signaling pathway","Apoptosis AND HIF-1 AND crosstalk","26884975","yes","yes","inhibiting","HIF1A","Q16665","UNIPROT","BCL2","P10415","UNIPROT","Homo sapiens","renal cell carcinoma cell","BTO:0000037","renal cell carcinoma","More importantly, treatment with allicin significantly decreased HIF-1α protein level, thereby reducing Bcl-2 and VEGF expression.","Without allicin treatment, HIF-1a increases expression of Bcl-2, which is an Apoptosis repressor.",""
+"HIF-1 signaling pathway","Apoptosis","Apoptosis AND HIF-1 AND crosstalk","26884975","no","","","","","","","","","","","","","","",""
+"Apoptosis","Hedgehog signaling pathway","Apoptosis AND Hedgehog AND pathway","25085524","","yes","activating","","","","GLI2","P10070","UNIPROT","Homo sapiens","SAOS-2 cell","BTO:0000971","cancer cell lines","Here, we provide new insights into the mechanism that controls the ability of ΔNp6α to enhance the malignant phenotype of OS cells and show that the expression of GLI2, a transcriptional activator and mediator of the Hedgehog (HH) signaling pathway, is regulated by ΔNp63α.","",""
+"Hedgehog signaling pathway","Apoptosis","Apoptosis AND Hedgehog AND pathway","25085524","no","","","","","","","","","","","","","","",""
+"Apoptosis","Hedgehog signaling pathway","Apoptosis AND Hedgehog AND pathway","18264131","no","","","","","","","","","","","","","","",""
+"Hedgehog signaling pathway","Apoptosis","Apoptosis AND Hedgehog AND pathway","18264131","yes","yes","inhibiting","GLI2","P10070","UNIPROT","BCL2","P10415","UNIPROT","Homo sapiens","basal cell carcinoma cell","BTO:0001298","","As Gli2 silencing does not only downregulate cFlip, but also Bcl-2, Gli2 could be a key target for a novel therapeutic approach in tumors with dysregulated Hedgehog signaling.","Gli2 silencing downregulates anti-apoptotic genes so increasing Gli2 should normally be anti-apoptotic.",""
+"Insulin secretion pathway","Apoptosis","Apoptosis AND Insulin secretion AND crosstalk","21163363","yes","no","activating","Iapp","P12969","UNIPROT","Casp8","Q9JHX4","UNIPROT","Rattus norvegicus","INS-1E cell","BTO:0003317","","Moreover, there was crosstalk between the extrinsic and intrinsic apoptotic pathways as demonstrated by cleavage of Bid by caspase-8 in the apoptotic process triggered by hIAPP.","hIAPP is a peptide, not protein, but is secreted with insulin and mediates crosstalk.",""
+"Apoptosis","Insulin secretion pathway","Apoptosis AND Insulin secretion AND crosstalk","21163363","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","NF-kappa B signaling pathway","Apoptosis AND Insulin secretion AND crosstalk","16283237","yes","no","activating","Mapk3/Mapk1","P21708/P63086","UNIPROT","Nfkb1","Q63369","UNIPROT","Rattus norvegicus","INS-1E cell","BTO:0003317","","ERK activity is required for NFkappaB-mediated transcription of Nos2 in insulin-producing INS-1E cells, indicating that ERK regulates Nos2 expression by increasing the transactivating capacity of NFkappaB.","",""
+"NF-kappa B signaling pathway","MAPK signaling pathway","Apoptosis AND Insulin secretion AND crosstalk","16283237","no","","","","","","","","","","","","","","",""
+"Apoptosis","Insulin secretion pathway","Apoptosis AND Insulin secretion AND crosstalk","19772917","no","","","","","","","","","","","","","","",""
+"Insulin secretion pathway","Apoptosis","Apoptosis AND Insulin secretion AND crosstalk","19772917","no","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","Apoptosis","Hippo AND Apoptosis AND crosstalk","27119551","yes","yes","inhibiting","LATS1","O95835","UNIPROT","BCL2L11","O43521","UNIPROT","Rattus norvegicus","pulmonary artery","BTO:0000778","","Molecular- and pharmacology-based analyses revealed that LATS1 inactivation and consequent up-regulation of its reciprocal effector Yes-associated protein (Yap) were required for activation of mammalian target of rapamycin (mTOR)-Akt, accumulation of HIF1α, Notch3 intracellular domain and β-catenin, deficiency of pro-apoptotic Bim, increased proliferation and survival of human PAH PAVSMC. ","",""
+"Apoptosis","Hippo signaling pathway","Hippo AND Apoptosis AND crosstalk","27119551","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","Apoptosis","Insulin AND Apoptosis AND crosstalk","27050276","no","","","","","","","","","","","","","","",""
+"Apoptosis","Insulin signaling pathway","Insulin AND Apoptosis AND crosstalk","27050276","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","Apoptosis","Insulin AND Apoptosis AND crosstalk","24608439","no","","","","","","","","","","","","","","",""
+"Apoptosis","Insulin signaling pathway","Insulin AND Apoptosis AND crosstalk","24608439","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","Apoptosis","Insulin AND Apoptosis AND crosstalk","24239558","no","","","","","","","","","","","","","","",""
+"Apoptosis","Insulin signaling pathway","Insulin AND Apoptosis AND crosstalk","24239558","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","Apoptosis","Insulin AND Apoptosis AND crosstalk","26094890","no","","","","","","","","","","","","","","",""
+"Apoptosis","Insulin signaling pathway","Insulin AND Apoptosis AND crosstalk","26094890","no","","","","","","","","","","","","","","",""
+"Apoptosis","Insulin signaling pathway","Apoptosis AND Insulin AND crosstalk","27000202","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","Apoptosis","Apoptosis AND Insulin AND crosstalk","27000202","no","","","","","","","","","","","","","","",""
+"Apoptosis","Insulin signaling pathway","Apoptosis AND Insulin AND crosstalk","27067637","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","Apoptosis","Apoptosis AND Insulin AND crosstalk","27067637","no","","","","","","","","","","","","","","",""
+"Apoptosis","Insulin signaling pathway","Apoptosis AND Insulin AND crosstalk","26896766","no","","","","","","","","","","","","","","",""
+"Insulin signaling pathway","Apoptosis","Apoptosis AND Insulin AND crosstalk","26896766","no","","","","","","","","","","","","","","",""
+"Apoptosis","Jak-STAT signaling pathway","Apoptosis AND Jak-STAT AND crosstalk","18441519","no","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","Apoptosis","Apoptosis AND Jak-STAT AND crosstalk","18441519","yes","unknown","inhibiting","Stat3","P52631","UNIPROT","Akt1","P47196","UNIPROT","Rattus norvegicus","muscle fibre","BTO:0000888","","In conclusion, cardiomyocytes possess an apoptosis-resistant property as a cytoprotection mechanism which is likely conferred by mutual transactivation between AKT/NF-kappaB and JAK2/STAT3, a novel crosstalk between the two signaling pathways within the networking governing the cell fate.","Crosstalk is reported here between Akt/NF kappa B and Jak/STAT pathways, however, increased levels of STAT3 suppressed apoptosis via interaction with Akt.",""
+"Apoptosis","Jak-STAT signaling pathway","Apoptosis AND Jak-STAT AND crosstalk","17584785","no","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","Apoptosis","Apoptosis AND Jak-STAT AND crosstalk","17584785","yes","yes","activating","ZMIZ1","Q9ULJ6","UNIPROT","TP53","P04637","UNIPROT","Homo sapiens","HCT-116 cell","BTO:0001109","","Furthermore, using chromatin immunoprecipitation assays, we demonstrate that hZimp10 binds to p53 on the p21 promoter. Finally, p53-mediated transcription is significantly impaired in Zimp10 null embryonic fibroblasts.","",""
+"Apoptosis","Melanogenesis","Apoptosis AND Melanogenesis AND crosstalk","25980672","no","","","","","","","","","","","","","","",""
+"Melanogenesis","Apoptosis","Apoptosis AND Melanogenesis AND crosstalk","25980672","no","","","","","","","","","","","","","","beta-catenin (involved in melanogenesis pathway) did not influence Bcl-2 expression","Note that in the model simulation, inhibition of either beta-catenin or CREB dramatically reduced melanin synthesis, but unlike beta-catenin, inhibition of CREB largely influenced the Bcl-2 expression."
+"Apoptosis","Melanogenesis","Apoptosis AND Melanogenesis AND crosstalk","22085498","no","","","","","","","","","","","","","","",""
+"Melanogenesis","Apoptosis","Apoptosis AND Melanogenesis AND crosstalk","22085498","no","","","","","","","","","","","","","","",""
+"Apoptosis","Melanogenesis","Apoptosis AND Melanogenesis AND crosstalk","27262506","no","","","","","","","","","","","","","","",""
+"Melanogenesis","Apoptosis","Apoptosis AND Melanogenesis AND crosstalk","27262506","no","","","","","","","","","","","","","","",""
+"Apoptosis","Melanogenesis","Apoptosis AND Melanogenesis AND crosstalk","26051519","no","","","","","","","","","","","","","","",""
+"Melanogenesis","Apoptosis","Apoptosis AND Melanogenesis AND crosstalk","26051519","no","","","","","","","","","","","","","","",""
+"Apoptosis","Melanogenesis","Apoptosis AND Melanogenesis AND crosstalk","22412813","no","","","","","","","","","","","","","","",""
+"Melanogenesis","Apoptosis","Apoptosis AND Melanogenesis AND crosstalk","22412813","no","","","","","","","","","","","","","","",""
+"Apoptosis","Melanogenesis","Apoptosis AND Melanogenesis AND crosstalk","18983540","no","","","","","","","","","","","","","","",""
+"Melanogenesis","Apoptosis","Apoptosis AND Melanogenesis AND crosstalk","18983540","no","","","","","","","","","","","","","","Pax3 is an upstream regulator of both Mift (melanogenesis) and regulates Bcl-x (apoptosis).",""
+"Apoptosis","Melanogenesis","Apoptosis AND Melanogenesis AND crosstalk","18602000","no","","","","","","","","","","","","","","",""
+"Melanogenesis","Apoptosis","Apoptosis AND Melanogenesis AND crosstalk","18602000","no","","","","","","","","","","","","","","",""
+"Apoptosis","Melanogenesis","Apoptosis AND Melanogenesis AND pathway","19289254","no","","","","","","","","","","","","","","",""
+"Melanogenesis","Apoptosis","Apoptosis AND Melanogenesis AND pathway","19289254","no","","","","","","","","","","","","","","",""
+"Apoptosis","Melanogenesis","Apoptosis AND Melanogenesis AND pathway","22431736","no","","","","","","","","","","","","","","Endocannabinoids stimulate melanogenesis and induce apoptosis.",""
+"Melanogenesis","Apoptosis","Apoptosis AND Melanogenesis AND pathway","22431736","no","","","","","","","","","","","","","","",""
+"Apoptosis","Melanogenesis","Apoptosis AND Melanogenesis AND pathway","20123016","no","","","","","","","","","","","","","","",""
+"Melanogenesis","Apoptosis","Apoptosis AND Melanogenesis AND pathway","20123016","no","","","","","","","","","","","","","","",""
+"Melanogenesis","Apoptosis","Apoptosis AND Melanogenesis AND pathway","18282187","yes","yes","inhibiting","MITF","O75030","UNIPROT","","","","Homo sapiens","melanocyte","BTO:0000847","UV radiation","We have shown that α-MSH, ACTH and endothelin-1 rescue human melanocytes from UV-induced apoptosis by activating the Akt survival pathway upstream from the transcription factor CREB, which in turn activates Mitf, the “master regulator” of melanocyte survival and melanin synthesis","cited: 15899821",""
+"Apoptosis","Melanogenesis","Apoptosis AND Melanogenesis AND pathway","18282187","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Apoptosis","Apoptosis AND MAPK AND crosstalk","24866280","yes","yes","inhibiting","MAPK1","P28482","UNIPROT","BCL2","P10415","UNIPROT","Homo sapiens","U-87MG cell","BTO:0002036","glioblastoma","Furthermore, inhibition of ERK1/2 by PD98059 enhanced the antitumor effect of β-elemene and impaired the expression levels of Bcl-2 and survivin.","",""
+"Apoptosis","MAPK signaling pathway","Apoptosis AND MAPK AND crosstalk","24866280","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Apoptosis","Apoptosis AND MAPK AND crosstalk","23010893","yes","no","activating","[Mapk14/Mapk11/Mapk12]","[P70618/D4A3U7/Q63538]","UNIPROT","Casp3","P55213","UNIPROT","Rattus norvegicus","myocardium","BTO:0000901","myocardial infarction","The PKC-δ-p38-MAPK-pathway as a strong signal for apoptosis in the non-infarcted myocardium can be influenced by targeting the anti-apoptotic PI3-kinase pathway.","",""
+"Apoptosis","MAPK signaling pathway","Apoptosis AND MAPK AND crosstalk","24866280","no","","","","","","","","","","","","","","",""
+"Apoptosis","MAPK signaling pathway","Apoptosis AND MAPK AND crosstalk","23010893","no","","","","","","","","","","","","","","",""
+"Apoptosis","NF-kappa B signaling pathway","Apoptosis AND NF-kappa B AND crosstalk","25967949","no","","","","","","","","","","","","","","pathways linked, but not crosstalk",""
+"NF-kappa B signaling pathway","Apoptosis","Apoptosis AND NF-kappa B AND crosstalk","25967949","no","","","","","","","","","","","","","pathways linked, but not crosstalk","",""
+"Apoptosis","NF-kappa B signaling pathway","Apoptosis AND NF-kappa B AND crosstalk","25732260","no","","","","","","","","","","","","","","",""
+"NF-kappa B signaling pathway","Apoptosis","NF-kappa B AND Apoptosis AND crosstalk","25732260","yes","yes","inhibiting","Grk5","Q62833","UNIPROT","Casp3","P55213","UNIPROT","Rattus norvegicus","neural stem cell","BTO:0002881","","We found that GRK5 siRNA inhibited anti-apoptotic Bcl-2 expression and upregulated pro-apoptotic caspase-3 activity.","",""
+"Apoptosis","NF-kappa B signaling pathway","NF-kappa B AND Apoptosis AND crosstalk","25704882","no","","","","","","","","","","","","","","",""
+"NF-kappa B signaling pathway","Apoptosis","NF-kappa B AND Apoptosis AND crosstalk","25704882","no","","","","","","","","","","","","","","",""
+"Apoptosis","NF-kappa B signaling pathway","NF-kappa B AND Apoptosis AND crosstalk","24802124","no","","","","","","","","","","","","","","",""
+"NF-kappa B signaling pathway","Apoptosis","NF-kappa B AND Apoptosis AND crosstalk","24802124","no","","","","","","","","","","","","","","",""
+"Apoptosis","Neurotrophin signaling pathway","Apoptosis AND Neurotrophin AND crosstalk","20100315","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Apoptosis","Apoptosis AND Neurotrophin AND crosstalk","20100315","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Apoptosis","Apoptosis AND Neurotrophin AND pathway","27194337","yes","unknown","activating","Ngfr","Q9Z0W1","UNIPROT","Casp3","P70677","UNIPROT","Mus musculus","brain","BTO:0000142","","The p75 neurotrophin receptor (p75NTR) mediates neuronal death in response to neural insults by activating a caspase apoptotic pathway.","p75 receptor is responsible for the induction of apoptosis. Study says it activates a caspase-dependent pathway but the immediate downstream effects of the receptor are unclear.",""
+"Apoptosis","Neurotrophin signaling pathway","Apoptosis AND Neurotrophin AND pathway","27194337","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Apoptosis","Apoptosis AND Neurotrophin AND pathway","26581032","yes","no","activating","NTRK2","Q16620","UNIPROT","[MAPK8/MAPK9]","[P45983/P45984]","UNIPROT","Homo sapiens","gingival epithelium","BTO:0004998","","BDNF facilitated not cell proliferation but cell apoptosis and JNK phosphorylation in OBA9 cells.","Does not specify JNK isoform. According to 18570871, JNK1 but not JNK2 phosphorylates Bcl-2 which is a possible mechanism.",""
+"Apoptosis","Neurotrophin signaling pathway","Apoptosis AND Neurotrophin AND pathway","26581032","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Apoptosis","Apoptosis AND Neurotrophin AND pathway","25749582","yes","yes","inhibiting","Ntrk2","Q63604","UNIPROT","Bax","Q63690","UNIPROT","Rattus norvegicus","PC-12 cell","BTO:0001009","cancer of adrenal glands","In this study, we found that K252a treatment reverses NaHS-induced downregulation of Bax protein and upregulation of Bcl-2 protein, indicting the important role of BDNF-Trk B pathway in the protection of H2S in PC12 cells.","K252a is a TrkB inhibitor. K252a reverses downregulation of Bax and upregulation of Bcl-2 meaning it reverses pro-survival. Therefore K252a is an apoptotic inducer, so TrkB must decrease apoptosis.",""
+"Apoptosis","Neurotrophin signaling pathway","Apoptosis AND Neurotrophin AND pathway","25749582","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Apoptosis","Apoptosis AND Neurotrophin AND pathway","26579945","yes","unknown","inhibiting","Ntrk2","P15209","UNIPROT","","","","Mus musculus","neuron","BTO:0000938","","Many of the pathological and behavioural consequences of TBI might be due to activation of the pro-neurotrophin/p75 toxic pathway overriding the protective mechanisms of the mature neurotrophin/Trk pathway.","TrkB agonist reduced neuronal apoptosis but p75ntr pathway has opposite effect. Did not have access to full article.",""
+"Apoptosis","Neurotrophin signaling pathway","Apoptosis AND Neurotrophin AND pathway","26579945","no","","","","","","","","","","","","","","",""
+"Notch signaling pathway","Apoptosis","Apoptosis AND Notch AND crosstalk","24286423","yes","no","inhibiting","Notch1","Q07008","UNIPROT","Akt1","P47196","UNIPROT","Rattus norvegicus","H9c2 cell","BTO:0001879","","Down-regulation of Notch1 by RNA interference can cause inhibition of SupT1 cell proliferation by inducing cell apoptosis, which may be mediated by regulating Akt activity.","Mechanism seems speculative.",""
+"Apoptosis","Notch signaling pathway","Apoptosis AND Notch AND crosstalk","24286423","no","","","","","","","","","","","","","","",""
+"Notch signaling pathway","Apoptosis","Apoptosis AND Notch AND crosstalk","18369158","yes","no","inhibiting","Notch1","Q01705","UNIPROT","Akt1","P31750","UNIPROT","Mus musculus","cardiac muscle fiber","BTO:0002320","","These results indicate Notch activation in cardiomyocytes is mediated through c-Met and Akt survival signaling pathways, and Notch1 signaling in turn enhances Akt activity. This mutually supportive crosstalk suggests a positive survival feedback mechanism between Notch and Akt signaling in adult myocardium following injury.","This crosstalk is also bidirectional crosstalk between Notch and PI3K/Akt pathways.",""
+"Apoptosis","Notch signaling pathway","Apoptosis AND Notch AND crosstalk","18369158","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","Apoptosis","Apoptosis AND Prolactin AND crosstalk","16520895","yes","yes","inhibiting","ODC1","P11926","UNIPROT","BCL2","P10415","UNIPROT","Homo sapiens","HL-60 cell","BTO:0000738","","These results suggest that increasing ODC activity is another way of prolactin preventing MTX-induced apoptosis and that this induction of ODC activity enhances the expression of Bcl-2 strongly enough to bring about the anti-apoptotic function.","",""
+"Apoptosis","Prolactin signaling pathway","Apoptosis AND Prolactin AND crosstalk","16520895","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","Apoptosis","Apoptosis AND Prolactin AND crosstalk","26346346","yes","no","inhibiting","STAT3","P40763","UNIPROT","BCL2","P10415","UNIPROT","Homo sapiens","HeLa cell","BTO:0000567","","Our data suggests that STAT3 is an important signaling pathway activated by PRL in cervical cancer cells and it modulates the induction of antiapoptotic genes.","",""
+"Apoptosis","Prolactin signaling pathway","Apoptosis AND Prolactin AND crosstalk","26346346","no","","","","","","","","","","","","","","",""
+"Apoptosis","TGF-beta signaling pathway","Apoptosis AND TGF-beta AND crosstalk","25127907","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Apoptosis","Apoptosis AND TGF-beta AND crosstalk","25127907","yes","yes","inhibiting","Tgfb1","P17246","UNIPROT","","","","Rattus norvegicus","annulus fibrosus","BTO:0003627","","In conclusion, TGF-β1 protected against apoptosis of AF cells under starvation through down-regulating excessive autophagy.","""PI3K-AKT-mTOR and MAPK-ERK1/2 were the possible signaling pathways involved in this process.""",""
+"Hedgehog signaling pathway","Notch signaling pathway","Hedgehog Notch Cross-talk","21649559","yes","yes","activating","GLI1","P08151","UNIPROT","HES5","Q5TA89","UNIPROT","Homo sapiens","embryonic stem cell","BTO:0001086","normal","Interestingly, HEY2 and HES5, NOTCH signaling transcription factors, were identified to be potential direct target genes of GLI, with 3 and 6 putative GLI-binding sites in their 5′ promoter region, respectively","",""
+"TGF-beta signaling pathway","Notch signaling pathway","Notch TGF-beta Crosstalk","24520074","yes","yes","activating","TGFB1","P01137","UNIPROT","HEY1","Q9Y5J3","UNIPROT","Homo sapiens","marrow cell","BTO:0001441","tumor progression","Conversely, TGF-β induces expression of the Notch ligand Jagged1 and target gene Hey1","Since TGF-beta induces expression of these Notch pathway components that is transcriptional crosstalk",""
+"Apoptosis","TNF signaling pathway","Apoptosis AND TNF AND crosstalk","24786365","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Apoptosis","Apoptosis AND TNF AND crosstalk","24786365","no","","","","","","","","","","","","","","",""
+"Apoptosis","TNF signaling pathway","Apoptosis AND TNF AND crosstalk","24582964","no","","","","","","","","","","","","","","intercellular crosstalk",""
+"TNF signaling pathway","Apoptosis","Apoptosis AND TNF AND crosstalk","24582964","no","","","","","","","","","","","","","","intercellular crosstalk",""
+"TNF signaling pathway","Apoptosis","Apoptosis AND TNF AND crosstalk","22374304","yes","no","inhibiting","TNFRSF1A","P19438","UNIPROT","NFKB1","P19838","UNIPROT","Homo sapiens","unknown","","","Activation of TNFR1 implies the consecutive formation of two different TNF receptor signalling complexes.","Information from review articles",""
+"Apoptosis","TNF signaling pathway","Apoptosis AND TNF AND crosstalk","22374304","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Apoptosis","Apoptosis AND TNF AND crosstalk","24318359","yes","no","activating","","","","","","","","","","","In this work we show that TRAF2 depletion leads to an enhanced cytotoxicity mediated by TNFR1 which correlates with the inhibition of NF-kB when both receptors are coexpressed and that TNFR2 mutants unable to induce TRAF2 degradation fail to enhance cytotoxicity.","TNFR2 depletes TRAF2 in the presence of TNFR1 leading to the inhibition of NF-kB and cell death.",""
+"Apoptosis","TNF signaling pathway","Apoptosis AND TNF AND crosstalk","24318359","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Apoptosis","Apoptosis AND TNF AND crosstalk","24337174","no","","","","","","","","","","","","","","does not mention TNF",""
+"Apoptosis","TNF signaling pathway","Apoptosis AND TNF AND crosstalk","24337174","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Apoptosis","Apoptosis AND TNF AND crosstalk","24396708","yes","yes","activating","Tnf","P06804","UNIPROT","Fas","P25446","UNIPROT","Mus musculus","hematopoietic stem cell","BTO:0000725","","The highly selective pattern of cognate receptor/ligand interactions is accompanied by inductive crosstalk, for example upregulation of Fas expression by TNF-α.","",""
+"Apoptosis","TNF signaling pathway","Apoptosis AND TNF AND crosstalk","24396708","no","","","","","","","","","","","","","","",""
+"Apoptosis","Thyroid hormone synthesis","Apoptosis AND Thyroid hormone synthesis AND crosstalk","24693967","no","","","","","","","","","","","","","","",""
+"Thyroid hormone synthesis","Apoptosis","Apoptosis AND Thyroid hormone synthesis AND crosstalk","24693967","unclear","","","","","","","","","","","","","","Paper reports that TH leads to increased apoptosis, but it is unclear whether this is due to its effects on Shh signaling.",""
+"Thyroid hormone synthesis","Hedgehog signaling pathway","Apoptosis AND Thyroid hormone synthesis AND crosstalk","24693967","yes","no","inhibiting","Prkaca","P05132","UNIPROT","Gli2","Q0VGT2","UNIPROT","Mus musculus","basal cell carcinoma cell","BTO:0001298","thyroid hormone treatment","T3 induces protein kinase A, which in turn destabilizes Gli2 protein via its C-terminal degron.","",""
+"Apoptosis","Thyroid hormone synthesis","Apoptosis AND Thyroid hormone synthesis AND crosstalk","9155013","no","","","","","","","","","","","","","","does not mention thyroid hormone synthesis",""
+"Thyroid hormone synthesis","Apoptosis","Apoptosis AND Thyroid hormone synthesis AND crosstalk","9155013","no","","","","","","","","","","","","","","does not mention thyroid hormone synthesis",""
+"Thyroid hormone synthesis","Apoptosis","Apoptosis AND Thyroid hormone synthesis AND crosstalk","19747164","no","","","","","","","","","Rattus norvegicus","granulosa cell","BTO:0000542","","","not about thyroid hormone synthesis; active TH inhibits apoptosis through PI3K/Akt pathway","Taken together, these results suggest that T₃ potentiates the cell survival action of FSH through inhibiting cell apoptosis and promoting cell proliferation."
+"Apoptosis","Toll-like receptor signaling pathway","Apoptosis AND Toll-like receptor AND crosstalk","22187010","no","","","","","","","","","","","","","","crosstalk between mitochondria and ER, not signaling pathways",""
+"Toll-like receptor signaling pathway","Apoptosis","Apoptosis AND Toll-like receptor AND crosstalk","22187010","no","","","","","","","","","","","","","","crosstalk between mitochondria and ER, not signaling pathways",""
+"Apoptosis","Toll-like receptor signaling pathway","Apoptosis AND Toll-like receptor AND crosstalk","18406372","no","","","","","","","","","","","","","","crosstalk between bacteria and their phages",""
+"Toll-like receptor signaling pathway","Apoptosis","Apoptosis AND Toll-like receptor AND crosstalk","18406372","no","","","","","","","","","","","","","","crosstalk between bacteria and their phages",""
+"Apoptosis","Toll-like receptor signaling pathway","Apoptosis AND Toll-like receptor AND crosstalk","23770291","no","","","","","","","","","","","","","","crosstalk between SIRT1 and NF-kB","We will examine the molecular mechanisms of the antagonistic signaling between NF-κB and SIRT1 and describe how this crosstalk controls inflammatory process and energy metabolism."
+"Toll-like receptor signaling pathway","Apoptosis","Apoptosis AND Toll-like receptor AND crosstalk","23770291","no","","","","","","","","","","","","","","","We will examine the molecular mechanisms of the antagonistic signaling between NF-κB and SIRT1 and describe how this crosstalk controls inflammatory process and energy metabolism."
+"Apoptosis","Toll-like receptor signaling pathway","Apoptosis AND Toll-like receptor AND crosstalk","23587629","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","Apoptosis","Apoptosis AND Toll-like receptor AND crosstalk","23587629","no","","","","","","","","","","","","","","",""
+"Apoptosis","Toll-like receptor signaling pathway","Apoptosis AND Toll-like receptor AND crosstalk","24245765","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","Apoptosis","Apoptosis AND Toll-like receptor AND crosstalk","24245765","no","","","","","","","","","","","","","","",""
+"Apoptosis","Toll-like receptor signaling pathway","Apoptosis AND Toll-like receptor AND crosstalk","27250735","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","Apoptosis","Apoptosis AND Toll-like receptor AND crosstalk","27250735","no","","","","","","","","","","","","","","miRNA crosstalk",""
+"Apoptosis","Toll-like receptor signaling pathway","Apoptosis AND Toll-like receptor AND crosstalk","27321649","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","Apoptosis","Apoptosis AND Toll-like receptor AND crosstalk","27321649","yes","yes","activating","TLR3","O15455","UNIPROT","FAS","P25445","UNIPROT","Homo sapiens","bronchial epithelial cell","BTO:0002922","","In this study, we showed that the TLR3 ligand poly I:C selectively and strongly induced bronchial epithelial cell apoptosis.","",""
+"Apoptosis","Toll-like receptor signaling pathway","Apoptosis AND Toll-like receptor AND crosstalk","27279424","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","Apoptosis","Apoptosis AND Toll-like receptor AND crosstalk","27279424","yes","no","activating","Tlr4","Q9QX05","UNIPROT","Nfkb1","Q63369","UNIPROT","Rattus norvegicus","cardiac muscle fiber","BTO:0002320","neonatal","In conclusion, our findings indicate that the apoptosis induced by ox-LDL in cultured neonatal rat cardiomyocytes at least in part by modulating the TLR4/NF-κB signaling pathway. ","",""
+"Apoptosis","VEGF signaling pathway","Apoptosis AND VEGF AND crosstalk","21778339","no","","","","","","","","","","","",""," Pericytes induced the antiapoptotic protein Bcl-w in tumor ECs both in vivo and in vitro, thereby conveying protection from cytotoxic damage.","intercellular crosstalk"," Pericytes induced the antiapoptotic protein Bcl-w in tumor ECs both in vivo and in vitro, thereby conveying protection from cytotoxic damage."
+"VEGF signaling pathway","Apoptosis","Apoptosis AND VEGF AND crosstalk","21778339","no","","","","","","","","","","","","","","intercellular crosstalk","Pericytes induced the antiapoptotic protein Bcl-w in tumor ECs both in vivo and in vitro, thereby conveying protection from cytotoxic damage."
+"Apoptosis","VEGF signaling pathway","Apoptosis AND VEGF AND crosstalk","17572663","yes","yes","inhibiting","BCL2L1","Q07817","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","dermal microvascular endothelial cell","BTO:0004574","","EGF and Bcl-x(L) activate the mitogen-activated protein kinase/ERK pathway resulting in upregulation of vascular endothelial growth factor (VEGF), a known inducer of Bcl-2 in endothelial cells.","does not specify VEGFA or VEGFB; Bcl-x is pro-survival so negative crosstalk",""
+"VEGF signaling pathway","Apoptosis","Apoptosis AND VEGF AND crosstalk","17572663","yes","yes","inhibiting","VEGFA","P15692","UNIPROT","BCL2","P10415","UNIPROT","Homo sapiens","dermal microvascular endothelial cell","BTO:0004574","","Inhibition of VEGF receptor signaling in HDMEC-Bcl-x(L) prevented Bcl-2 upregulation and demonstrated the function of a VEGF-mediated autocrine loop.","does not specify VEGFA or VEGFB; Bcl-2 is pro-survival so negative crosstalk",""
+"Apoptosis","VEGF signaling pathway","Apoptosis AND VEGF AND crosstalk","16096368","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Apoptosis","Apoptosis AND VEGF AND crosstalk","16096368","no","","","","","","","","","","","","","","",""
+"Apoptosis","VEGF signaling pathway","Apoptosis AND VEGF AND crosstalk","27158386","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Apoptosis","Apoptosis AND VEGF AND crosstalk","27158386","yes","no","","PIK3CA","P42336","UNIPROT","","","","Homo sapiens","SAOS-2 cell","BTO:0000971","cells were subcutaneously innoculated in rat","Our data demonstrated that VEGF silencing could suppress cells proliferation, promote cells apoptosis and reduce osteosarcoma angiogenesis through inactivation of VEGF/PI3K/AKT signaling pathway.","",""
+"Apoptosis","Wnt signaling pathway","Apoptosis AND Wnt AND crosstalk","27045591","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Apoptosis","Apoptosis AND Wnt AND crosstalk","27045591","yes","yes","inhibiting","Ctnnb1","Q9WU82","UNIPROT","NR4A2","P43354","UNIPROT","Rattus norvegicus","PC-12 cell","BTO:0001009","","In conclusion, the data suggested that Wnt/β-catenin and Nurr1 are crucial factors in the survival of DA neurons, and the activation of Wnt/β-catenin pathway exerts protective effects on DA neurons partly by mean of a co-active pattern with Nurr1.","",""
+"Apoptosis","Wnt signaling pathway","Apoptosis AND Wnt AND crosstalk","24402132","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Apoptosis","Apoptosis AND Wnt AND crosstalk","24402132","yes","yes","inhibiting","CTNNB1","P35222","UNIPROT","AKT1","P31749","UNIPROT","Homo sapiens","pancreatic cancer cell","BTO:0000584","","Taken together, the results of the current study represent the first evidence of β-catenin signal crosstalk during the G2/M phase by functionally inactivating Akt via witha-D treatment in pancreatic cancer cells.","witha-D treatment caused beta-catenin degradation, leading to increased apoptosis",""
+"Wnt signaling pathway","Apoptosis","Apoptosis AND Wnt AND crosstalk","23296977","yes","no","inhibiting","Wnt3a","P27467","UNIPROT","Akt1","P31750","UNIPROT","Mus musculus","pancreas","BTO:0000988","","Our results demonstrated that Wnt3a regulates proliferation, apoptosis and enhances function of pancreatic NIT-1 beta cells via activation of Wnt/β-catenin signaling, involving crosstalk with IRS2/PI3K signaling, with the effect of Wnt signaling on beta-cells also being IRS2/PI3K/AKT dependent.","",""
+"Apoptosis","Wnt signaling pathway","Apoptosis AND Wnt AND crosstalk","23296977","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Apoptosis","Apoptosis AND Wnt AND crosstalk","23362257","yes","yes","inhibiting","Ctnnb1","Q02248","UNIPROT","Mapk1","P63085","UNIPROT","Mus musculus","MLO-Y4 cell","BTO:0005489","","In summary, on the basis of our findings, we propose that accumulation of β-catenin is essential for mechanotransduction and that its localization within caveolae is required for full activation of the caveolin-1/ERK signaling pathway leading to osteocyte survival.","",""
+"Apoptosis","mTOR signaling pathway","Apoptosis AND mTOR AND crosstalk","26121028","no","","","","","","","","","","","","","","miRNA crosstalk",""
+"mTOR signaling pathway","Apoptosis","Apoptosis AND mTOR AND crosstalk","26121028","no","","","","","","","","","","","","","","miRNA crosstalk",""
+"mTOR signaling pathway","Apoptosis","Apoptosis AND mTOR AND crosstalk","25987255","no","no","","","","","","","","","","","","","",""
+"Apoptosis","mTOR signaling pathway","Apoptosis AND mTOR AND crosstalk","25987255","yes","yes","activating","JUN","P05412","UNIPROT","AKT1","P31749","UNIPROT","Homo sapiens","T-lymphoma cell line","BTO:0003212","lymphoma","Synergistic action between AP-1 and STAT3 on AKT1 transcription was observed which contributed to increased cell survival and proliferation.","",""
+"mTOR signaling pathway","Apoptosis","Apoptosis AND mTOR AND crosstalk","25561006","no","","","","","","","","","","","","","","does not talk specifically about mTOR signaling",""
+"Apoptosis","mTOR signaling pathway","Apoptosis AND mTOR AND crosstalk","25792811","no","","","","","","","","","","","","","","does not specifically mention mTOR",""
+"mTOR signaling pathway","Apoptosis","Apoptosis AND mTOR AND crosstalk","25792811","no","","","","","","","","","","","","","","does not specifically mention mTOR",""
+"Apoptosis","mTOR signaling pathway","Apoptosis AND mTOR AND crosstalk","24865460","no","","","","","","","","","","","","","","",""
+"mTOR signaling pathway","Apoptosis","Apoptosis AND mTOR AND crosstalk","24865460","yes","no","inhibiting","MTOR","P42345","UNIPROT","BAD","Q92934","UNIPROT","Homo sapiens","adrenocortical cell","BTO:0005817","","In conclusion, mTORC1 pathway is activated by PKA signaling in human and mouse adrenocortical cells, leading to increased cell survival, which is correlated with BAD hyperphosphorylation.","",""
+"TNF signaling pathway","NF-kappa B signaling pathway","TNF AND ""NF-kB""","8530143","yes","no","activating","","","","","","","","","","","Data from our laboratory demonstrate that the TNF signal transduction pathway-mediating NF-kappa B activation involves two phospholipases, a phosphatidylcholine-specific phospholipase C (PC-PLC) and an endosomal acidic sphingomyelinase (aSMase).","",""
+"Hedgehog signaling pathway","Apoptosis","Apoptosis AND Hedgehog AND pathway","18264131","yes","yes","inhibiting","GLI2","P10070","UNIPROT","CFLAR","O15519","UNIPROT","Homo sapiens","basal cell carcinoma cell","BTO:0001298","","","",""
+"mTOR signaling pathway","Adherens junction","Adherens AND mTOR AND pathway","25600338","yes","no","activating","","","","","","","","osteoclast","BTO:0000968","","We elucidate that hAJ activates the mTOR pathway in cancer cells, which drives the progression from single cells to micrometastases.","",""
+"mTOR signaling pathway","Adherens junction","Adherens AND mTOR AND pathway","25600338","yes","no","activating","","","","","","","","MDA-MB-231 cell","BTO:0000815","","We elucidate that hAJ activates the mTOR pathway in cancer cells, which drives the progression from single cells to micrometastases.","",""
+"MAPK signaling pathway","Wnt signaling pathway","MAPK Wnt Crosstalk","22494969","yes","no","inhibiting","","","","","","","","","","","Accordingly, Biechele et al. found that inhibition of MEK, the kinase phosphorylated and stimulated by BRAF, also enhanced Wnt/β-catenin signaling.","",""
+"MAPK signaling pathway","Wnt signaling pathway","MAPK Wnt Crosstalk","22494969","yes","no","inhibiting","BRAF","P15056","UNIPROT","[AXIN1/AXIN2]","[O15169/Q9Y2T1]","UNIPROT","Homo sapiens","melanoma cell","BTO:0000848","","In melanoma cells, inhibition of BRAF combined with Wnt/β-catenin activation caused proteasome-dependent degradation of Axin, inhibition of GSK3, and consequent dephosphorylation of β-catenin on the GSK3 target sites.","",""
+"MAPK signaling pathway","Wnt signaling pathway","MAPK Wnt Crosstalk","22494969","yes","no","inhibiting","BRAF","P15056","UNIPROT","GSK3A/GSK3B","P49840/P49841","UNIPROT","Homo sapiens","melanoma cell","BTO:0000848","","In melanoma cells, inhibition of BRAF combined with Wnt/β-catenin activation caused proteasome-dependent degradation of Axin, inhibition of GSK3, and consequent dephosphorylation of β-catenin on the GSK3 target sites.","",""
+"mTOR signaling pathway","HIF-1 signaling pathway","mTOR HIF-1 Cross-talk","24164895","yes","yes","activating","EIF4EBP1","Q13541","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","","","","","",""
+"Jak-STAT signaling pathway","Toll-like receptor signaling pathway","Jak/STAT AND Toll-Like Receptor","17502339","yes","yes","inhibiting","","","","","","","","","","","IFN-gamma suppresses TLR2 and TLR4 induction/activation of AP-1 by overlapping mechanisms that include regulation of MAPKs, GSK3-dependent suppression of DNA binding, and decreased Fos and Jun protein expression and stability.","",""
+"Jak-STAT signaling pathway","Toll-like receptor signaling pathway","Jak/STAT AND Toll-Like Receptor","17502339","yes","no","inhibiting","IFNG","P01579","UNIPROT","TLR4","O00206","UNIPROT","Homo sapiens","macrophage","BTO:0000801","","IFN-y suppresses TLR2 and TLR4 induction/activation of AP-1","",""
+"GnRH signaling pathway","Apoptosis","GnRH AND Apoptosis AND pathway","25811175","","no","inhibiting","GNRHR","P30968","UNIPROT","CASP7,CASP3","P55210,P42574","UNIPROT","Homo sapiens","prostate gland cancer cell","BTO:0001130","","We found that degarelix treatment induces an increase of caspase 3/7 activation in all prostate cells analyzed","Degarilix is a GnRHR antagonist, so the treatment of the drug blocked the effects of GnRHR which activated apoptosis, so there must be a negative crosstalk",""
+"Estrogen signaling pathway","Notch signaling pathway","Notch Estrogen Crosstalk","21193018","yes","yes","activating","ESR1","P03372","UNIPROT","JAG1","P78504","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","","E2 promoted 8-fold and 6-fold increase in Notch1 and JAG1 expression, respectively, in breast cancer MCF-7 cells","",""
+"Adipocytokine signaling pathway","Notch signaling pathway","Notch Leptin Crosstalk","21193018","yes","no","activating","LEP","P41159","UNIPROT","NOTCH3","Q9UM47","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","","We recently observed that leptin was able to activate Notch signaling pathway (Notch1,3,4 NICD and CSL) in mouse (4T1, EMT6 and MMT) and human breast cancer cell lines (MCF-7 and MDA-MB-231) under normoxic conditions","",""
+"Adipocytokine signaling pathway","Notch signaling pathway","Notch Leptin Crosstalk","21193018","yes","no","activating","LEP","P41159","UNIPROT","NOTCH4","Q99466","UNIPROT","Homo sapiens","MCF-7 cell","BTO:0000093","","We recently observed that leptin was able to activate Notch signaling pathway (Notch1,3,4 NICD and CSL) in mouse (4T1, EMT6 and MMT) and human breast cancer cell lines (MCF-7 and MDA-MB-231) under normoxic conditions","",""
+"Adipocytokine signaling pathway","Notch signaling pathway","Notch Leptin Crosstalk","24202338","yes","yes","activating","LEP","P41159","UNIPROT","JAG1","P78504","UNIPROT","Homo sapiens","blood vessel endothelium","BTO:0000766","","Leptin was found to regulate the expression of Notch4 receptor and its ligand, JAG1 in human endothelial and blood CD34+ cells","",""
+"VEGF signaling pathway","Notch signaling pathway","Notch VEGF Cross-talk","23239744","yes","yes","activating","VEGFA","P15692","UNIPROT","ADAM10","O14672","UNIPROT","Homo sapiens","acute myeloid leukemia cell","BTO:0001545","angiogenesis","Indeed, VEGF is shown to upregulate both presenilin and ADAM10 expression, increase presenilin proteolytic processing and γ-secretase activity in endothelial cells, and result in activation of Dll4 and Notch1","",""
+"VEGF signaling pathway","Notch signaling pathway","Notch VEGF Cross-talk","23239744","yes","yes","activating","VEGFA","P15692","UNIPROT","ADAM10","O14672","UNIPROT","Homo sapiens","bone marrow endothelial cell line","BTO:0003126","angiogenesis","Indeed, VEGF is shown to upregulate both presenilin and ADAM10 expression, increase presenilin proteolytic processing and γ-secretase activity in endothelial cells, and result in activation of Dll4 and Notch1","",""
+"TNF signaling pathway","Neurotrophin signaling pathway","TNF AND Neurotrophin AND (crosstalk OR ""cross-talk"")","18094051","yes","no","inhibiting","TNFRSF1A","P19438","UNIPROT","AKT1","P31749","UNIPROT","Homo sapiens","neuroblastoma cell","BTO:0000931","","Although nerve growth factor (NGF) promotes survival of neurons, tumor necrosis factor alpha (TNF-alpha) contributes to cell death triggered by NGF depletion, through TNF-alpha receptor (TNFR) 1.","",""
+"TNF signaling pathway","Neurotrophin signaling pathway","TNF AND Neurotrophin AND (crosstalk OR ""cross-talk"")","18094051","yes","no","activating","TNFRSF1B","P20333","UNIPROT","MAPK1","P28482","UNIPROT","Homo sapiens","neuroblastoma cell","BTO:0000931","","In contrast to this effect, TNF-alpha can promote neural cell survival via TNF-alpha receptor TNFR2.","",""
+"Wnt signaling pathway","HIF-1 signaling pathway","NF-kappa B Wnt Crosstalk","21502812","yes","yes","inhibiting","CTNNB1","P35222","UNIPROT","NFKB1","P19838","UNIPROT","Homo sapiens","HCT-116 cell","BTO:0001109","","Our data indicate that loss-of-function mutations in APC result in the engagement of the hypoxia response.","could also be NFKB2; crosstalk likely context-dependent because inhibition of NF-kappaB is seen in mutated APC which coincides with high levels of free beta-catenin",""
+"Neurotrophin signaling pathway","HIF-1 signaling pathway","Neurotrophin AND HIF-1 AND crosstalk","16618748","no","","","","","","","","","","","","","","BDNF activation of TrkB eventually leads to HIF-1alpha and VEGF expresssion, but requires PI3K/mTOR. A possible explaination is TrkB -> IRS1 -> PI3K -> Akt -> NF-kB -> HIF-1alpha expression which would be indirect.","The BDNF-stimulated increases in HIF-1alpha and VEGF expression required TrkB tyrosine kinase activity and were completely blocked by inhibitors of phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) pathways."
+"HIF-1 signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND HIF-1 AND crosstalk","16618748","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","HIF-1 signaling pathway","Neurotrophin AND HIF-1 AND crosstalk","21145972","yes","yes","activating","Akt1","P31750","UNIPROT","Hif1a","Q61221","UNIPROT","Mus musculus","neuron","BTO:0000938","","Our study indicates that neurotrophin activation of Trk stimulates an increase in VEGF transcription that is mediated by induction of HIF-1α.","",""
+"HIF-1 signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND HIF-1 AND crosstalk","17374610","yes","yes","activating","HIF1A","Q16665","UNIPROT","NTRK2","Q16620","UNIPROT","Homo sapiens","neuroblastoma cell","BTO:0000931","","Our findings indicate that transcription of the NTRK2 gene is stimulated at low oxygen tension through a HIF-1-dependent mechanism.","",""
+"HIF-1 signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND HIF-1 AND crosstalk","24462831","yes","yes","activating","HIF1A","Q16665","UNIPROT","BDNF","P23560","UNIPROT","Homo sapiens","pulmonary artery endothelial cell line","BTO:0003150","","These results indicate that human PAECs express and secrete BDNF in response to hypoxia via a HIF-1-regulated pathway.","",""
+"Neurotrophin signaling pathway","HIF-1 signaling pathway","Neurotrophin AND HIF-1 AND crosstalk","24462831","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","GnRH signaling pathway","Neurotrophin AND GnRH AND pathway","27121963","no","","","","","","","","","","","","","","network analysis",""
+"GnRH signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND GnRH AND pathway","27121963","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","GnRH signaling pathway","Neurotrophin AND GnRH AND pathway","16162927","no","","","","","","","","","","","","","","mentions both pathways but no crosstalk",""
+"GnRH signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND GnRH AND pathway","16162927","no","","","","","","","","","","","","","","mentions both pathways but no crosstalk",""
+"TGF-beta signaling pathway","Notch signaling pathway","TGF-beta AND Notch AND crosstalk","14638857","yes","no","activating","SMAD3","P84023","UNIPROT","[Q9W737]","[Q9W737]","UNIPROT","Gallus gallus","embryo","BTO:0000379","","Together, these results suggest that Smad3 can be recruited to the promoter regions of Notch target genes via direct interaction with NICD","This mechanism upregulates both Notch and TGF-B signaling. NICD:Smad3:Smad4 complex is TF for HES-1 and PAI-1 promoters.",""
+"Adherens junction","Adipocytokine signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Adherens junction","GnRH signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Adherens junction","Insulin secretion pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Adherens junction","Progesterone-mediated oocyte maturation","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Adherens junction","Prolactin signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Adherens junction","Thyroid hormone synthesis","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","Neurotrophin signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","Prolactin signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Apoptosis","Progesterone-mediated oocyte maturation","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Adipocytokine signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","Adherens junction","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","HIF-1 signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","Hippo signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","Prolactin signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","Adipocytokine signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","GnRH signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","Prolactin signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Insulin secretion pathway","Adherens junction","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Insulin secretion pathway","Melanogenesis","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Insulin secretion pathway","Progesterone-mediated oocyte maturation","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Melanogenesis","Insulin secretion pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Adipocytokine signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Hippo signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Prolactin signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Progesterone-mediated oocyte maturation","Adherens junction","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Progesterone-mediated oocyte maturation","Apoptosis","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Progesterone-mediated oocyte maturation","Insulin secretion pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","Adherens junction","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","Adipocytokine signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","HIF-1 signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","Hippo signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","Neurotrophin signaling pathway","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"Thyroid hormone synthesis","Adherens junction","","NO_RESULTS_FOR_PUBMED_QUERY","","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Jak-STAT signaling pathway","ErbB AND Jak-STAT AND pathway","26398764","no","","","","","","","","","","","","","","Review paper; no access to full text.","Recent studies on the genomic landscape of gastric adenocarcinoma have identified several key signaling molecules, including epidermal growth factor receptor family (ErbB) members, vascular endothelial growth factor receptor family (VEGFR) members and PI3K/Akt/mTOR pathway components, that have been implicated in the molecular pathogenesis of gastric cancers."
+"Jak-STAT signaling pathway","ErbB signaling pathway","ErbB AND Jak-STAT AND pathway","26398764","no","","","","","","","","","","","","","","Review article; no access to full text.","Recent studies on the genomic landscape of gastric adenocarcinoma have identified several key signaling molecules, including epidermal growth factor receptor family (ErbB) members, vascular endothelial growth factor receptor family (VEGFR) members and PI3K/Akt/mTOR pathway components, that have been implicated in the molecular pathogenesis of gastric cancers."
+"ErbB signaling pathway","Jak-STAT signaling pathway","ErbB AND Jak-STAT AND pathway","12204892","yes","no","activating","NRG1","Q02297","UNIPROT","JAK3","P52333","UNIPROT","Homo sapiens","NCI-H520 cell","","","In this study, we show that NRG-1 activates the Janus kinases (JAK) and signal transducer and activator of transcription proteins (STAT).","",""
+"ErbB signaling pathway","Jak-STAT signaling pathway","ErbB AND Jak-STAT AND pathway","12204892","yes","no","activating","NRG1","Q02297","UNIPROT","TYK2","P29597","UNIPROT","Homo sapiens","NCI-H520 cell","","","In this study, we show that NRG-1 activates the Janus kinases (JAK) and signal transducer and activator of transcription proteins (STAT).","",""
+"Jak-STAT signaling pathway","ErbB signaling pathway","ErbB AND Jak-STAT AND pathway","12204892","no","","","","","","","","","","","","","","other direction",""
+"ErbB signaling pathway","Jak-STAT signaling pathway","ErbB AND Jak-STAT AND pathway","15078989","yes","no","activating","ERBB2","P04626","UNIPROT","STAT3","P40763","UNIPROT","human","A-431 cell","","","Our study suggests that residual ErbB2 activation by EGF, despite EGFR blockade, is responsible for persistent downstream activation of Stat-3.","",""
+"Jak-STAT signaling pathway","ErbB signaling pathway","ErbB AND Jak-STAT AND pathway","15078989","no","","","","","","","","","","","","","","other direction",""
+"ErbB signaling pathway","Jak-STAT signaling pathway","ErbB AND Jak-STAT AND pathway","21590492","no","","","","","","","","","","","","","","","In summary, our findings suggest that SOCS3 inactivation by promoter hypermethylation is mutually exclusive to EGFR activation in gliomas and preferentially promotes glioma cell invasion through STAT3 and FAK activation."
+"Jak-STAT signaling pathway","ErbB signaling pathway","ErbB AND Jak-STAT AND pathway","21590492","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Jak-STAT signaling pathway","ErbB AND Jak-STAT AND pathway","17346677","yes","yes","activating","ERBB2","P04626","UNIPROT","PTPN11","Q06124","UNIPROT","human","urinary bladder cancer cell line","","","After the cells had been treated with AG825, a HER-2/neu-specific inhibitor, SHP-2 expression declined, and Jak2/Stat1 reactivated.","cell lines used: TCC-N5 and TCC-N10 but not found in BTO.",""
+"Jak-STAT signaling pathway","ErbB signaling pathway","ErbB AND Jak-STAT AND pathway","17346677","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Neurotrophin signaling pathway","ErbB AND Neurotrophin AND pathway","15470130","no","","","","","","","","","","","","","","Neurotrophin-3 downregulated in spiral ganglion neurons with mutated NRG1 but not enough evidence for crosstalk.","Quantitative RT-PCR analysis of neurotrophic factor expression shows a specific downregulation in expression of neurotrophin-3 (NT3) in the transgenic cochleas before the onset of neuronal death. "
+"Neurotrophin signaling pathway","ErbB signaling pathway","ErbB AND Neurotrophin AND pathway","15470130","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Neurotrophin signaling pathway","ErbB AND Neurotrophin AND pathway","16524373","no","","","","","","","","","","","","","","Interplay between pathways, but no crosstalk.","Because motor neurons express both p75NTR and neuregulin erbB receptors during the period of embryonic programmed cell death, motor neuron survival may be the result of complex interactions between trophic and death factors, which may be the same molecules acting in different combinations."
+"Neurotrophin signaling pathway","ErbB signaling pathway","ErbB AND Neurotrophin AND pathway","16524373","no","","","","","","","","","","","","","","Interplay between pathways, but no crosstalk.","Because motor neurons express both p75NTR and neuregulin erbB receptors during the period of embryonic programmed cell death, motor neuron survival may be the result of complex interactions between trophic and death factors, which may be the same molecules acting in different combinations."
+"Estrogen signaling pathway","HIF-1 signaling pathway","Estrogen AND HIF-1 AND crosstalk","24916446","no","","","","","","","","","","","","","","does not discuss estrogen signaling",""
+"HIF-1 signaling pathway","Estrogen signaling pathway","Estrogen AND HIF-1 AND crosstalk","24916446","no","","","","","","","","","","","","","","does not discuss estrogen signaling",""
+"Estrogen signaling pathway","HIF-1 signaling pathway","Estrogen AND HIF-1 AND crosstalk","10822009","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","Estrogen signaling pathway","Estrogen AND HIF-1 AND crosstalk","10822009","unclear","","","","","","","","","","","","","AhR agonists including TCDD, benzo[a]pyrene (BaP) and 6-methyl-1,3,8-trichlorodibenzofuran, inhibited 32-47% of the E2-induced responses.","",""
+"Estrogen signaling pathway","HIF-1 signaling pathway","Estrogen AND HIF-1 AND crosstalk","26598706","yes","yes","activating","ESR1","P03372","UNIPROT","HIF1A","Q16665","UNIPROT","human","MCF-7 cell","","","Interestingly, the HIF-1α gene itself also bears an estrogen response element, and its expression is directly regulated by ERα. ","ERa binds directly to HIF1A promoter.",""
+"HIF-1 signaling pathway","Estrogen signaling pathway","Estrogen AND HIF-1 AND crosstalk","26598706","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","Estrogen signaling pathway","Estrogen AND HIF-1 AND crosstalk","23382692","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","HIF-1 signaling pathway","Estrogen AND HIF-1 AND crosstalk","23382692","yes","no","activating","ERR","Q8WS79","UNIPROT","tgo","O15945","UNIPROT","Drosophila melanogaster","larva","","hypoxia","dERR binds to dHIFa and participates in the HIF-dependent transcriptional program in hypoxia.","",""
+"Estrogen signaling pathway","HIF-1 signaling pathway","Estrogen AND HIF-1 AND crosstalk","18791496","no","yes","inhibiting","","","","","","","Mus musculus","cardiac muscle fiber","BTO:0002320","trauma-hemorrhage","","estrogen increases IL-6 levels, not necessarily estrogen signaling","These results indicate that the beneficial effects of estrogen on cardiac function after trauma-hemorrhage seem to be mediated by the inhibition of HIF-1 alpha expression and activity."
+"HIF-1 signaling pathway","Estrogen signaling pathway","Estrogen AND HIF-1 AND crosstalk","21458421","yes","yes","inhibiting","HIF1A","Q16665","UNIPROT","ESR1","P03372","UNIPROT","Homo sapiens","MCF-7 cell","","hypoxia","Repression of ESR1 gene transcription occurred at the transcriptional level as a result of decreased recruitment of RNA polymerase II at the proximal promoter of the ESR1 locus in response to stabilization of the HIF-1α protein under hypoxia","",""
+"Estrogen signaling pathway","HIF-1 signaling pathway","Estrogen AND HIF-1 AND crosstalk","21458421","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Hippo signaling pathway","Estrogen AND Hippo AND pathway","25893606","yes","no","activating","GPER1","Q99527","UNIPROT","YAP1","P46937","UNIPROT","Homo sapiens","breast invasive ductal carcinoma cell","","","Additionally, our studies revealed that GPER stimulation activates yes-associated protein 1 (YAP) and transcriptional coactivator with a PDZ-binding domain (TAZ), 2 homologous transcription coactivators and key effectors of the Hippo tumor suppressor pathway, via the Gαq-11, PLCβ/PKC, and Rho/ROCK signaling pathways.","",""
+"Hippo signaling pathway","Estrogen signaling pathway","Estrogen AND Hippo AND pathway","25893606","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Hippo signaling pathway","Estrogen AND Hippo AND pathway","27289045","no","","","","","","","","","","","","","","Association of expression levels but not enough information to conclude crosstalk.","Our data indicate that NF2 expression is associated with aromatase and AREG expression, being elevated in HCC tissues and HepG2 cells, intermediate in cirrhotic tissues and Huh7 cells, and lower in nontumoral liver and HA22T cells."
+"Hippo signaling pathway","Estrogen signaling pathway","Estrogen AND Hippo AND pathway","27289045","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","TNF signaling pathway","Estrogen AND TNF AND crosstalk","23932046","no","","","","","","","","","","","","","","Review article; only mentioned both pathways.",""
+"TNF signaling pathway","Estrogen signaling pathway","Estrogen AND TNF AND crosstalk","23932046","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","TNF signaling pathway","Estrogen AND TNF AND crosstalk","16618756","no","","","","","","","","","","","","","","estradiol metabolite 2-methoxyestradial augments TRAIL induced apoptosis but not enough evidence that estrogen signaling has downstream effect on TNF signaling","Interestingly, the endogenous angiogenesis inhibitor 2-methoxyestradiol augments FasL/TRAIL-induced apoptosis in these cells."
+"TNF signaling pathway","Estrogen signaling pathway","Estrogen AND TNF AND crosstalk","16618756","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","TNF signaling pathway","Estrogen AND TNF AND crosstalk","24213015","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Estrogen signaling pathway","Estrogen AND TNF AND crosstalk","24213015","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","TNF signaling pathway","Estrogen AND TNF AND crosstalk","26878683","yes","yes","inhibiting","","","","","","","unknown","vascular smooth muscle cell","","","17β-estradiol (E2) inhibited TRAIL expression under TNF-α stimulation in a time- and concentration-dependent manner.","ERa required for E2 inhibition of TRAIL expression. Mechanism requires supression of NF-kB signaling. No access to full article.",""
+"TNF signaling pathway","Estrogen signaling pathway","Estrogen AND TNF AND crosstalk","26878683","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","TNF signaling pathway","Estrogen AND TNF AND crosstalk","21784129","yes","no","activating","TNF","P01375","UNIPROT","ESR1","P03372","UNIPROT","Homo sapiens","Ishikawa cell","","","Co-treatment with a pure ER antagonist resulted in an inhibition of this TNF-α-induced ERE luciferase activity and gene expression, demonstrating that this cytokine signals through ERs.","TNF-a induces expression of estrogen-regulated genes. Appears transcriptional at first glance but likely protein-protein interaction since ERa activity required.",""
+"Estrogen signaling pathway","TNF signaling pathway","Estrogen AND TNF AND crosstalk","24737445","yes","yes","activating","Esr2","O08537","UNIPROT","Tnfaip1","O70479","UNIPROT","Mus musculus","hippocampus","","","Additional experiments demonstrated the existence of a binding site of ERβ in the Tnfaip1 promoter region, and that ERβ was able to upregulate Tnfaip1 expression.","",""
+"Estrogen signaling pathway","VEGF signaling pathway","Estrogen AND VEGF AND pathway","24758741","yes","yes","activating","ESR1/ESR2","P03372/Q92731","UNIPROT","SNAI2","O43623","UNIPROT","Homo sapiens","Ishikawa cell","","","Consistently, E2 also up-regulated VEGF expression and raloxifene abrogated E2-induced VEGF expression in Ishikawa cells","",""
+"VEGF signaling pathway","Estrogen signaling pathway","Estrogen AND VEGF AND pathway","24758741","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","VEGF signaling pathway","Estrogen AND VEGF AND pathway","24894716","yes","yes","activating","GPER1","Q99527","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","SK-BR-3 cell","","","We demonstrated that 17β-estradiol (E2) and the GPER-selective ligand G-1 triggered a GPER/EGFR/ERK/c-fos signaling pathway that leads to increased VEGF via upregulation of HIF1α.","",""
+"GnRH signaling pathway","Adipocytokine signaling pathway","GnRH AND Adipocytokine AND pathway","19662887","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","GnRH signaling pathway","GnRH AND Adipocytokine AND pathway","19662887","unclear","","","","","","","","","","","","","In pubertal girls, leptin extensively released into circulation at the moment when adipose tissue reaches a critical volume, stimulates synthesis of GnRH and induces puberty, which is followed by striking increases in bone mass.","No access to full article. Leptin stimulates GnRH synthesis so possible crosstalk.",""
+"GnRH signaling pathway","Jak-STAT signaling pathway","GnRH AND Jak-STAT AND pathway","15927772","no","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","GnRH signaling pathway","GnRH AND Jak-STAT AND pathway","15927772","no","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","GnRH signaling pathway","GnRH AND Jak-STAT AND pathway","21209203","yes","yes","activating","Jak2","Q62120","UNIPROT","Gnrh1","P13562","UNIPROT","Mus musculus","hypothalamus","BTO:0000614","","GnRH mRNA levels were reduced in Jak2 G(-/-) mice when compared with controls, while the number of GnRH neurons was equivalent, indicating a reduction in GnRH gene expression.","",""
+"GnRH signaling pathway","Jak-STAT signaling pathway","GnRH AND Jak-STAT AND pathway","21209203","no","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","Prolactin signaling pathway","GnRH AND Prolactin AND crosstalk","4358345","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","GnRH signaling pathway","GnRH AND Prolactin AND crosstalk","4358345","no","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","Prolactin signaling pathway","GnRH AND Prolactin AND pathway","22416085","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","GnRH signaling pathway","GnRH AND Prolactin AND pathway","22416085","no","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","Prolactin signaling pathway","GnRH AND Prolactin AND pathway","7828532","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","GnRH signaling pathway","GnRH AND Prolactin AND pathway","7828532","no","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","Prolactin signaling pathway","GnRH AND Prolactin AND pathway","6138106","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","GnRH signaling pathway","GnRH AND Prolactin AND pathway","6138106","no","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","Prolactin signaling pathway","GnRH AND Prolactin AND pathway","18162529","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","GnRH signaling pathway","GnRH AND Prolactin AND pathway","18162529","no","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","TGF-beta signaling pathway","GnRH AND TGF-beta AND pathway","14678567","no","","","","","","","","","","","","","","retracted",""
+"TGF-beta signaling pathway","GnRH signaling pathway","GnRH AND TGF-beta AND pathway","14678567","no","","","","","","","","","","","","","","retracted",""
+"TGF-beta signaling pathway","GnRH signaling pathway","GnRH AND TGF-beta AND pathway","15531510","no","","","","","","","","","","","","","","Both act on MAPK signaling, but no crosstalk.",""
+"GnRH signaling pathway","TGF-beta signaling pathway","GnRH AND TGF-beta AND pathway","15531510","no","","","","","","","","","","","","","","Both act on MAPK signaling, but no crosstalk.",""
+"TGF-beta signaling pathway","GnRH signaling pathway","GnRH AND TGF-beta AND pathway","24588206","yes","yes","activating","Tgfb1","P17246","UNIPROT","Gnrh1","P07490","UNIPROT","Rattus norvegicus","preoptic area","","","We have demonstrated glial-derived TGFβ1 induces GnRH gene expression in the POA and stimulates release of the peptide from the MBH, actions necessary for driving the pubertal process.","",""
+"GnRH signaling pathway","TGF-beta signaling pathway","GnRH AND TGF-beta AND pathway","10819775","no","","","","","","","","","","","","","Based on these observations, we conclude that the majority of the LHRH-releasing activity of HA CM is due to TGF-β1","",""
+"TGF-beta signaling pathway","GnRH signaling pathway","GnRH AND TGF-beta AND pathway","10819775","unclear","unknown","activating","Tgfb1","P17246","UNIPROT","Gnrh1","P07490","UNIPROT","Rattus norvegicus","GT1-7 cell","","","Based on these observations, we conclude that the majority of the LHRH-releasing activity of HA CM is due to TGF-β1","TGF-B1 causes LHRH secretion",""
+"GnRH signaling pathway","TGF-beta signaling pathway","GnRH AND TGF-beta AND pathway","14604812","yes","yes","inhibiting","[GNRH1/GNRH2]","[P01148/O43555]","UNIPROT","TGFBR1/TGFBR2","P36897/P37173","UNIPROT","Homo sapiens","leiomyoma cell","","","GnRHa therapy resulted in lowering of TGF-betaRs as well as Smad4 and pSmad3, with concurrent increased in Smad7 expression in both leiomyoma and myometrium compared to untreated group (P<0.05).","Smad7 inhibits pSmad3 so increasing Smad7 is also inhibiting crosstalk",""
+"GnRH signaling pathway","TNF signaling pathway","GnRH AND TNF AND pathway","24389027","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","GnRH signaling pathway","GnRH AND TNF AND pathway","24389027","no","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","Wnt signaling pathway","GnRH AND Wnt AND crosstalk","22607396","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","GnRH signaling pathway","GnRH AND Wnt AND crosstalk","22607396","no","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","Wnt signaling pathway","GnRH AND Wnt AND pathway","20133385","unclear","no","activating","GNRHR","P30968","UNIPROT","CTNNB1","P35222","UNIPROT","Homo sapiens","HEK-293 cell","","","Indeed, several recent studies have demonstrated that GnRH, acting at the GnRH receptor, can target mediators of the Wnt/β-catenin signalling pathway in both a heterologous HEK293 model cell line and the LβT2 gonadotrope cell line.","This is a review that cites several primaries. It is unclear whether this is crosstalk because GnRH seems to be targeting Wnt mediators in order to regulate the expression of its own target genes.",""
+"Wnt signaling pathway","GnRH signaling pathway","GnRH AND Wnt AND pathway","20133385","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","Hippo signaling pathway","HIF-1 AND Hippo AND crosstalk","26059435","yes","no","activating","HIF1A","Q16665","UNIPROT","TAZ","Q16635","UNIPROT","Homo sapiens","MDA-MB-231 cell","","","Here, we report that direct protein-protein interaction between HIF-1α and TAZ has reciprocal effects: HIF-1α stimulates transactivation mediated by TAZ and TAZ stimulates transactivation mediated by HIF-1α.","",""
+"Hippo signaling pathway","HIF-1 signaling pathway","HIF-1 AND Hippo AND crosstalk","26059435","yes","no","inhibiting","TAZ","Q16635","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","MDA-MB-231 cell","","","Here, we report that direct protein-protein interaction between HIF-1α and TAZ has reciprocal effects: HIF-1α stimulates transactivation mediated by TAZ and TAZ stimulates transactivation mediated by HIF-1α.","",""
+"HIF-1 signaling pathway","Hippo signaling pathway","HIF-1 AND Hippo AND crosstalk","25587023","yes","yes","activating","HIF1A","Q16665","UNIPROT","WWTR1","Q9GZV5","UNIPROT","Homo sapiens","breast cancer cell line","","","Here we report that hypoxia-inducible factor 1 (HIF-1) triggers the expression and activity of TAZ, a transcriptional co-activator that is required for BCSC maintenance, through two discrete mechanisms.","",""
+"Hippo signaling pathway","HIF-1 signaling pathway","HIF-1 AND Hippo AND crosstalk","25587023","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","Jak-STAT signaling pathway","HIF-1 AND Jak-STAT AND pathway","25833080","no","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","HIF-1 signaling pathway","HIF-1 AND Jak-STAT AND pathway","25833080","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","Jak-STAT signaling pathway","HIF-1 AND Jak-STAT AND pathway","16878149","yes","yes","inhibiting","BHLHE40","O14503","UNIPROT","STAT1","P42224","UNIPROT","Homo sapien","renal cell carcinoma cell line","","","First, we showed that VHL deficiency or HIF-1 activation resulted in the repression of endogenous STAT1 mediated by STRA13.","",""
+"Jak-STAT signaling pathway","HIF-1 signaling pathway","HIF-1 AND Jak-STAT AND pathway","16878149","no","","","","","","","","","","","","","","",""
+"NF-kappa B signaling pathway","HIF-1 signaling pathway","HIF-1 AND NF-kappa B AND crosstalk","19456861","yes","no","activating","NFKBIA","P25963","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","HEK-293 cell","","","Functionally, IkappaB alpha expression further enhanced the transcriptional activity of HIF-1alpha under hypoxic conditions.","",""
+"HIF-1 signaling pathway","NF-kappa B signaling pathway","HIF-1 AND NF-kappa B AND crosstalk","19456861","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","NF-kappa B signaling pathway","HIF-1 AND NF-kappa B AND crosstalk","22068612","yes","yes","activating","HIF1A","Q16665","UNIPROT","PTGS2","P35354","UNIPROT","Homo sapiens","HEK-293 cell","","","Furthermore, we demonstrate synergistic activity between these two transcription factors on the regulation of the COX-2 promoter, implicating a co-ordinated role for both HIF and NFκB in the expression of COX-2 in hypoxic inflammation.","",""
+"Hippo signaling pathway","ErbB signaling pathway","Hippo AND ErbB AND pathway","25492965","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","Hippo signaling pathway","Hippo AND ErbB AND pathway","25492965","yes","no","activating","ERBB4","Q15303","UNIPROT","YAP1","P46937","UNIPROT","Homo sapiens","breast cancer cell line","","","We found that ERBB4 activated the transcriptional coactivator YAP, which promotes organ and tissue growth and is inhibited by the Hippo tumor-suppressor pathway.","",""
+"ErbB signaling pathway","Hippo signaling pathway","Hippo AND ErbB AND pathway","24356468","unclear","unknown","inhibiting","ERBB2","P04626","UNIPROT","ILK","Q13418","UNIPROT","Homo sapiens","breast cancer cell line","","","","ILK inactivates Hippo, but unclear whether ERBB2 is responsible for the ILK induction. ",""
+"Hippo signaling pathway","ErbB signaling pathway","Hippo AND ErbB AND pathway","24356468","no","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","ErbB signaling pathway","Hippo AND ErbB AND pathway","26417066","yes","yes","inhibiting","YAP1","P46937","UNIPROT","EGFR","P00533","UNIPROT","Homo sapiens","cervical cancer cell line","","","Activated YAP allows for up-regulation of TGF-α, AREG, and EGFR, forming a positive signaling loop to drive cervical cancer cell proliferation.","TGF-a suppresses Hippo signaling thereby activating YAP which increases EGFR expression.",""
+"ErbB signaling pathway","Hippo signaling pathway","Hippo AND ErbB AND pathway","26417066","yes","no","inhibiting","EGFR","P00533","UNIPROT","LATS1:MOB1A","O95835:Q9H8S9","UNIPROT","Homo sapiens","cervical cancer cell line","","","Treatment of ME180 cells with TGF-α resulted in a rapid increase in the phosphorylation of the EGFR and activation of the PI3K and MAPK signaling pathways.","TGF-a suppresses Hippo signaling thereby activating YAP which increases EGFR expression. This mechanism requires PI3K/MAPK signaling.",""
+"Hippo signaling pathway","Insulin secretion pathway","Hippo AND Insulin secretion AND pathway","27053234","yes","no","inhibiting","Stk4","Q9JI11","UNIPROT","Pdx1","P52946","UNIPROT","Mus musculus","pancreatic beta cell","","","We found that MST1 is strongly activated in a diabetic beta cell and induces not only its death but also directly impairs insulin secretion through promoting proteasomal degradation of key beta cell transcription factor, pancreatic and duodenal homeobox 1 (PDX1), which is critical for insulin production","",""
+"Insulin secretion pathway","Hippo signaling pathway","Hippo AND Insulin secretion AND pathway","27053234","no","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","VEGF signaling pathway","Hippo AND VEGF AND pathway","24837142","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Hippo signaling pathway","Hippo AND VEGF AND pathway","24837142","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Hippo signaling pathway","Hippo AND VEGF AND pathway","24159576","no","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","VEGF signaling pathway","Hippo AND VEGF AND pathway","24159576","no","","","","","","","","","","","","","","",""
+"Insulin secretion pathway","Wnt signaling pathway","Insulin secretion AND Wnt AND pathway","23296977","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Insulin secretion pathway","Insulin secretion AND Wnt AND pathway","23296977","yes","yes","activating","Wnt3a","P27467","UNIPROT","Pdx1","P52946","UNIPROT","Mus musculus","pancreatic beta cell line","","","Wnt3a also promoted NIT-1 cell proliferation, inhibited cytokine-induced beta-cell apoptosis, and increased insulin secretion.","",""
+"Jak-STAT signaling pathway","Estrogen signaling pathway","Jak-STAT AND Estrogen AND crosstalk","23434684","no","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","Estrogen signaling pathway","Jak-STAT AND Estrogen AND crosstalk","23434684","no","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","TGF-beta signaling pathway","Jak-STAT AND TGF-beta AND pathway","24333535","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Jak-STAT signaling pathway","Jak-STAT AND TGF-beta AND pathway","24333535","no","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","TNF signaling pathway","Jak-STAT AND TNF AND crosstalk","23185365","no","","","","","","","","","","","","","","",""
+"Jak-STAT signaling pathway","TNF signaling pathway","Jak-STAT AND TNF AND crosstalk","25666529","no","","","","","","","","","","","","","","Not clear that Jak1 causes TNF expression.","These results revealed increased TNF-α and NF-κB expression and decreased IkB-α levels in both the LPS alone and 4-MeH treated groups in whole blood and synovial fluid. Further, IL-1β, TNF-α, and NF-κB mRNA levels were significantly increased and western blot analysis confirmed increased expression of TNF-α, NF-κB, JAK-1, and STAT-3 in both LPS and 4-MeH treatment groups. "
+"Jak-STAT signaling pathway","TNF signaling pathway","Jak-STAT AND TNF AND crosstalk","24151609","yes","unknown","activating","JAK2","O60674","UNIPROT","IL6","P05231","UNIPROT","Homo sapiens","U-266 cell","","","TNF α -stimulated IL-6 production was abolished by inhibition of JAK2 and IKK β or by small interfering RNA (siRNA) targeting TNF receptors (TNFR) but not by MEK, p38, and PI3K inhibitors.","",""
+"MAPK signaling pathway","ErbB signaling pathway","MAPK AND ErbB AND crosstalk","22425775","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Adipocytokine signaling pathway","MAPK AND Adipocytokine AND crosstalk","19183933","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","MAPK signaling pathway","MAPK AND Adipocytokine AND crosstalk","26019302","yes","no","activating","Prkaa2","Q8BRK8","UNIPROT","[Mapk14/Mapk11]","[P47811/Q9WUI1]","UNIPROT","Mus musculus","C2C12 cell","","","The present results indicate that visfatin plays an important role in glucose metabolism via the Ca(2) (+)-mediated AMPK-p38 MAPK pathway.","Visfatin activates p38 MAPK signaling to help metabolize glucose.",""
+"MAPK signaling pathway","Adipocytokine signaling pathway","MAPK AND Adipocytokine AND crosstalk","26019302","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","MAPK signaling pathway","MAPK AND Adipocytokine AND crosstalk","24885580","yes","no","activating","NAMPT","P43490","UNIPROT","[MAPK11/MAPK14/MAPK12]","[Q15759/Q16539/P53778]","UNIPROT","Homo sapiens","NCI-H292 cell","","","These results suggest that visfatin induces MUC8 and MUC5B expression through p38 MAPK/ROS/NF-κB signaling pathway in human airway epithelial cells.","",""
+"MAPK signaling pathway","Adipocytokine signaling pathway","MAPK AND Adipocytokine AND crosstalk","24885580","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","ErbB signaling pathway","MAPK AND ErbB AND crosstalk","22425775","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","MAPK signaling pathway","MAPK AND ErbB AND crosstalk","22425775","no","no","activating","ERBB2:ERBB3","P04626:P21860","UNIPROT","","","","Homo sapiens","SK-BR-3 cell","","","Therefore, HRG-β1-induced migration and invasion partly depend on the upregulation of GPR30 expression through activation of the ErbB2-ERK pathway in SkBr3 cells.","",""
+"MAPK signaling pathway","ErbB signaling pathway","MAPK AND ErbB AND crosstalk","22425775","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","GnRH signaling pathway","MAPK AND GnRH AND crosstalk","22922893","no","","","","","","","","","","","","","","",""
+"GnRH signaling pathway","MAPK signaling pathway","MAPK AND GnRH AND crosstalk","22922893","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","GnRH signaling pathway","MAPK AND GnRH AND crosstalk","26644469","no","","","","","","","","","","","","","","Talks about negative feedback from MAPK to GnRH, but not crosstalk.",""
+"GnRH signaling pathway","MAPK signaling pathway","MAPK AND GnRH AND crosstalk","26644469","yes","no","activating","GNRHR","P30968","UNIPROT","MAPK1","P28482","UNIPROT","Homo sapiens","HeLa cell","","","Consistent with this, experiments revealed that reducing negative feedback (by expressing catalytically inactive ERK2) and increasing negative feedback (by Egr1-driven expression of dual-specificity phosphatase 5 (DUSP5)) both reduced information transfer from GnRHR to ERK.","",""
+"GnRH signaling pathway","MAPK signaling pathway","MAPK AND GnRH AND crosstalk","22235371","yes","no","activating","","","","","","","","hypothalamus","BTO:0000614","","In this paper, we reviewed and mainly focused on our observations of the pattern of ERK activation and the induction of MKP by different frequencies of GnRH stimulation.","GnRH pulses use MAPK signaling to control expression of of gonadotropins.",""
+"MAPK signaling pathway","GnRH signaling pathway","MAPK AND GnRH AND crosstalk","22235371","unclear","","","","","","","","","","","","","","GnRH signal uses MAPK pathway to affect gene expression. Unclear whether this is considered crosstalk because elements of both pathways are downstream of the other.",""
+"MAPK signaling pathway","HIF-1 signaling pathway","MAPK AND HIF-1 AND crosstalk","22609851","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","MAPK signaling pathway","MAPK AND HIF-1 AND crosstalk","22609851","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","HIF-1 signaling pathway","MAPK AND HIF-1 AND crosstalk","22609851","no","","","","","","","","","","","","","","Discusses MAPK and VEGF pathways. HIF1A is a VEGF inducer.","Increases in VEGF and NADPH oxidase levels were abrogated by inhibitors of NADPH oxidase and MAPK, respectively, suggesting the possibility of crosstalk between pathways."
+"HIF-1 signaling pathway","MAPK signaling pathway","MAPK AND HIF-1 AND crosstalk","22609851","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","HIF-1 signaling pathway","MAPK AND HIF-1 AND pathway","20393480","yes","no","activating","MAPK11","Q15759","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","keratinocyte","","UVB Irradiation","Furthermore, p38(MAPK) was required for the induction and activation of hypoxia-inducible factor 1 (HIF-1) in response to UVB, and HIF-1 knockdown reduced Noxa expression and apoptosis.","",""
+"MAPK signaling pathway","Prolactin signaling pathway","MAPK AND Prolactin AND pathway","23729680","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","MAPK signaling pathway","MAPK AND Prolactin AND pathway","23729680","yes","","","PRLR","P16471","UNIPROT","","","","Homo sapiens","HCMEC/D3 cell","","STAT5A overexpression","Medium conditioned by CA-STAT5A-overexpressing EC induces phosphorylation of the PRL receptor and activates MAPK.","",""
+"Prolactin signaling pathway","MAPK signaling pathway","MAPK AND Prolactin AND pathway","25446202","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Prolactin signaling pathway","MAPK AND Prolactin AND pathway","25446202","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","MAPK signaling pathway","MAPK AND Prolactin AND pathway","21726627","yes","no","activating","PRLR","P16471","UNIPROT","RAC1,[PAK1/PAK2/PAK3/PAK4/PAK6/PAK7]","P63000,[Q13153/Q13177/O75914/O96013/Q9NQU5/Q9P286]","UNIPROT","Homo sapiens","breast cancer cell line","",""," activated PRL-R mainly utilizes the PI3-kinase-dependent Rac/PAK pathway rather than the canonical Shc/Grb2/SOS/Ras route to initiate and sustain ERK1/2 signaling.","",""
+"MAPK signaling pathway","Prolactin signaling pathway","MAPK AND Prolactin AND pathway","21726627","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Prolactin signaling pathway","MAPK AND Prolactin AND pathway","8702944","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","MAPK signaling pathway","MAPK AND Prolactin AND pathway","8702944","yes","no","inhibiting","Prl","P06879","UNIPROT","Egfr","Q01279","UNIPROT","Mus musculus","NMuMg cell","","","The studies demonstrate that PRL either directly or indirectly inhibits the ability of EGF to induce EGF-R association with Grb2, to activate Ras, and to activate and phosphorylate MAPK.","",""
+"MAPK signaling pathway","Prolactin signaling pathway","MAPK AND Prolactin AND pathway","20813052","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","MAPK signaling pathway","MAPK AND Prolactin AND pathway","20813052","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Prolactin signaling pathway","MAPK AND Prolactin AND pathway","10406461","yes","yes","activating","","","","Prl","P01237","UNIPROT","Rattus norvegicus","GH3 cell","","","Treatment with the MAPKK inhibitor, PD98059, blocked TRH-induced activation of MAPK and also reduced TRH induction of a PRL-luciferase reporter gene, confirming that MAPK activation is necessary for TRH effects on PRL gene expression. ","",""
+"Prolactin signaling pathway","MAPK signaling pathway","MAPK AND Prolactin AND pathway","10406461","no","","","","","","","","","","","","","","",""
+"MAPK signaling pathway","Toll-like receptor signaling pathway","MAPK AND Toll-like receptor AND crosstalk","23612802","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","MAPK signaling pathway","MAPK AND Toll-like receptor AND crosstalk","23612802","yes","no","activating","TLR4","O00206","UNIPROT","[MAPK11/MAPK14]","[Q15759/Q16539]","UNIPROT","Homo sapiens","T-24 cell","","","Activation of TLR4 signaling by LPS resulted in phosphorylation of MAPK and STAT pathways and upregulation of IL-10 in dose- and time-dependent manners in T24 cells.","",""
+"Toll-like receptor signaling pathway","MAPK signaling pathway","MAPK AND Toll-like receptor AND crosstalk","21125645","yes","no","activating","Myd88","Q6Y1S1","UNIPROT","Mapk1","P63086","UNIPROT","Rattus norvegicus","astrocyte","BTO:0000099",""," Mitogen-activated protein kinases (MAPK) were also involved in TLR4 signaling in a MyD88-independent fashion.","",""
+"MAPK signaling pathway","Toll-like receptor signaling pathway","MAPK AND Toll-like receptor AND crosstalk","21125645","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND Adipocytokine AND pathway","24874077","yes","no","","LEP","P41159","UNIPROT","SIRT1","Q96EB6","UNIPROT","Homo sapiens","SH-SY5Y cell","","","Our results demonstrate for the first time that leptin attenuates the activation and transcriptional activity of NF-κB by reducing the acetylation of the p65 subunit in a SIRT1-dependent manner.","",""
+"NF-kappa B signaling pathway","Adipocytokine signaling pathway","NF-kappa B AND Adipocytokine AND pathway","24874077","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND Adipocytokine AND pathway","25108154","yes","no","inhibiting","Prkaa1","P54645","UNIPROT","Rela","Q7TQN4","UNIPROT","Rattus norvegicus","adipose tissue","","perivascular adipose tissue, fructose fed rats","AMPK activating agents inhibited NF-κB p65 phosphorylation and suppressed gene expression of pro-inflammatory adipocytokines, and upregulated adiponectin and PPARγ expression in PVAT in an AMPK/SIRT1-interdependent manner.","",""
+"NF-kappa B signaling pathway","Adipocytokine signaling pathway","NF-kappa B AND Adipocytokine AND pathway","25108154","no","","","","","","","","","","","","","","AMPK inhibits p65 subunit of NF-kB to regulate adipocytokine expression.",""
+"NF-kappa B signaling pathway","Adipocytokine signaling pathway","NF-kappa B AND Adipocytokine AND pathway","22508335","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND Adipocytokine AND pathway","22508335","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND Adipocytokine AND pathway","23670349","no","","","","","","","","","","","","","","",""
+"NF-kappa B signaling pathway","Adipocytokine signaling pathway","NF-kappa B AND Adipocytokine AND pathway","23670349","unclear","unknown","activating","Nfkb1","P25799","UNIPROT","Nampt","Q99KQ4","UNIPROT","Mus musculus","3T3-L1 cell","","","Moreover, inhibition of NF-κB by PDTC reduced the basal visfatin release while having no effect on the transcription regulation by GLP-1.","Did not have access to full text.",""
+"Adipocytokine signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND Adipocytokine AND pathway","18690350","yes","no","inhibiting","ADIPOQ","Q15848","UNIPROT","PRKACA","P17612","UNIPROT","Homo sapiens","HUVEC cell","","","These results suggested that Adp inhibits TF expression through inhibition of a PKA dependent nuclear factor-kappaB (NF-kappaB) signaling pathway.","",""
+"NF-kappa B signaling pathway","Adipocytokine signaling pathway","NF-kappa B AND Adipocytokine AND pathway","18690350","no","","","","","","","","","","","","","","",""
+"NF-kappa B signaling pathway","ErbB signaling pathway","NF-kappa B AND ErbB AND crosstalk","17700572","no","","","","","","","","","","","","","The inverse correlation between NF-kappaB activation and ER activation is due to EGFR and/or ErbB2 overexpression, resulting in NF-kappaB activation and ER downregulation.","",""
+"ErbB signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND ErbB AND crosstalk","17700572","yes","no","activating","ERBB2","P04626","UNIPROT","NFKB1","P19838","UNIPROT","Homo sapiens","breast cancer cell","","","The inverse correlation between NF-kappaB activation and ER activation is due to EGFR and/or ErbB2 overexpression, resulting in NF-kappaB activation and ER downregulation.","",""
+"ErbB signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND ErbB AND crosstalk","19946332","yes","no","activating","ERBB2","P04626","UNIPROT","CHUK","O15111","UNIPROT","Homo sapiens","SK-BR-3 cell","","","Using Her2(+)/ER(-) breast cancer cells, we show that Her2 activates NF-kappaB through the canonical pathway which, surprisingly, involves IKKalpha.","",""
+"NF-kappa B signaling pathway","ErbB signaling pathway","NF-kappa B AND ErbB AND crosstalk","19946332","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND ErbB AND crosstalk","22492965","yes","no","activating","ERBB3","P21860","UNIPROT","NFKB1","P19838","UNIPROT","Homo sapiens","breast cancer cell line","","","These findings illustrate that HRG/ErbB3 signaling appears to maintain mammosphere formation through a PI3K/NF-κB pathway in human breast cancer.","",""
+"NF-kappa B signaling pathway","ErbB signaling pathway","NF-kappa B AND ErbB AND crosstalk","22492965","no","","","","","","","","","","","","","","",""
+"NF-kappa B signaling pathway","Hippo signaling pathway","NF-kappa B AND Hippo AND pathway","22227519","no","","","","","","","","","","","","","","",""
+"NF-kappa B signaling pathway","Hippo signaling pathway","NF-kappa B AND Hippo AND pathway","25761670","no","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND Hippo AND pathway","25761670","yes","no","inhibiting","MST2","Q9JI10","UNIPROT","","","","Mus musculus ","osteoclast","","","Osteoclast precursors lacking Mst2 exhibit increased osteoclastogenesis and Nfatc1, Acp5, and Oscar expression in response to receptor activator of NF-κB ligand (RANKL) exposure.","RANKL induces osteoclast differentiation through NF-kB signaling and Mst2 attenuates this.",""
+"NF-kappa B signaling pathway","Prolactin signaling pathway","NF-kappa B AND Prolactin AND pathway","20826756","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND Prolactin AND pathway","19706735","yes","no","activating","PRL","P01236","UNIPROT","RELA","Q04206","UNIPROT","Homo sapiens","HUVEC cell","",""," Our data showed that endostatin, anginex, angiostatin, and the 16-kDa N-terminal fragment of human prolactin induced NF-kappaB activation in endothelial cells in both cultured human endothelial cells and in vivo in a mouse tumor model.","",""
+"NF-kappa B signaling pathway","Prolactin signaling pathway","NF-kappa B AND Prolactin AND pathway","19706735","no","","","","","","","","","","","","","","",""
+"NF-kappa B signaling pathway","Prolactin signaling pathway","NF-kappa B AND Prolactin AND pathway","12475392","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND Prolactin AND pathway","12475392","yes","no","activating","Prl","P01237","UNIPROT","Nfkbib","Q9JIA3","UNIPROT","Rattus norvegicus","GH3 cell","","","Altogether, these results show that 16K PRL activates NF-kappaB nuclear translocation via the phosphorylation and degradation of IkappaB-beta.","",""
+"NF-kappa B signaling pathway","Prolactin signaling pathway","NF-kappa B AND Prolactin AND pathway","12475392","no","","","","","","","","","","","","","","",""
+"NF-kappa B signaling pathway","TGF-beta signaling pathway","NF-kappa B AND TGF-beta AND crosstalk","24075100","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND TGF-beta AND crosstalk","24075100","yes","no","activating","Smad3","Q8BUN5","UNIPROT","Map3k7","Q62073","UNIPROT","Mus musculus","keratinocyte","","","These studies demonstrate that intact TGFβ1 signaling is required for NFκB-dependent gene expression in mouse keratinocytes and skin and suggest that a convergence of these pathways in the nucleus rather than the cytoplasm may be critical for regulation of inflammatory pathways in skin by TGFβ1. ","",""
+"TGF-beta signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND TGF-beta AND crosstalk","25337707","no","unknown","","","","","","","","","","","","",""," In A549 cells, KY-05009 significantly and strongly inhibited the TGF-β-activated EMT through the attenuation of Smad and non-Smad signaling pathways, including the Wnt, NF-κB, FAK-Src-paxillin-related focal adhesion, and MAP kinases (ERK and JNK) signaling pathways."
+"NF-kappa B signaling pathway","TGF-beta signaling pathway","NF-kappa B AND TGF-beta AND crosstalk","25337707","no","","","","","","","","","","","","","","",""
+"NF-kappa B signaling pathway","TGF-beta signaling pathway","NF-kappa B AND TGF-beta AND crosstalk","10839991","yes","yes","inhibiting","RELA","Q04206","UNIPROT","SMAD7","O15105","UNIPROT","Homo sapiens","HEK-293 cell","","","Expression of NF-kappaB p65 subunit was able to inhibit the Smad7 promoter activity, and this inhibition could be reversed by co-expression of IkappaB, an inhibitor of NF-kappaB.","",""
+"TGF-beta signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND TGF-beta AND crosstalk","10839991","no","","","","","","","","","","","","","","",""
+"NF-kappa B signaling pathway","TNF signaling pathway","NF-kappa B AND TNF AND crosstalk","26239406","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND TNF AND crosstalk","26239406","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND TNF AND crosstalk","23922887","yes","no","activating","TNF","P23563","UNIPROT","RELA","B0LXP3","UNIPROT","Sus scrofa","retinal pigment epithelium cell","","polarized retinal pigment epithelium cell","TNF-α inactivated JNK in P-RPE cells but activated it in N-RPE cells, and TNF-α activated NF-κB in P-RPE cells but not in N-RPE cells.","TNF-a inactivates JNK and activates NF-kB.",""
+"NF-kappa B signaling pathway","TNF signaling pathway","NF-kappa B AND TNF AND crosstalk","23922887","yes","no","inhibiting","RELA","B0LXP3","UNIPROT","MAPK8","I3LBY5","UNIPROT","Sus scrofa","retinal pigment epithelium cell","","polarized retinal pigment epithelium cell","In polarized RPE cells, JNK was already activated and NF-κB was inactivated, thus activation of NF-κB became significant after TNF-α exposure compared to control leading to inhibition of JNK and down-regulation of the VEGF expression.","NF-kB activation in polarized RPE cells inhibits TNF-induced JNK activation.",""
+"TNF signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND TNF AND crosstalk","24603712","yes","no","activating","Tnfrsf1a","P25118","UNIPROT","Rela","Q04207","UNIPROT","Mus musculus","C2C12 cell","","beta-agonist treatment","In summary, we show that β-agonists potentiate TNF-α action, via nuclear crosstalk, that promotes chromatin relaxation at selected gene promoters.","",""
+"NF-kappa B signaling pathway","TNF signaling pathway","NF-kappa B AND TNF AND crosstalk","24603712","yes","yes","activating","Rela","Q04207","UNIPROT","Il6","P08505","UNIPROT","Mus musculus","C2C12 cell","","beta-agonist treatment","Using the IL-6 promoter as a model, we demonstrated that TNF-α/isoproterenol cotreatment provoked phosphorylation of histone H3 at serine 10, concomitant with enhanced promoter accessibility and recruitment of the NF-κB p65 subunit, cAMP-response element-binding protein (CREB), CREB-binding protein (CBP) and RNA polymerase II.","",""
+"NF-kappa B signaling pathway","TNF signaling pathway","NF-kappa B AND TNF AND crosstalk","26103469","yes","yes","activating","Sp1","O89090","UNIPROT","Tnf","P06804","UNIPROT","Mus musculus","lung","BTO:0000763","LPS","Enhancing tissue level of Sp1 activity by inhibiting NF-κB-mediated Sp1 down-regulation increased tissue level of IL-10 and decreased tissue level of TNF- αin the lungs.","",""
+"NF-kappa B signaling pathway","Toll-like receptor signaling pathway","NF-kappa B AND Toll-like receptor AND crosstalk","25549945","no","","","","","","","","","","","","","","","In addition, NOD2 expression was up-regulated by its agonist muramyl dipeptide (MDP), along with receptor interacting protein 2 (RIP2), nuclear factor κB (NFκB)-p65, inhibitor of NFκB (IκB)-α, and multiple inflammatory cytokines, including interleukin-6 (IL-6), IL-8 and tumor necrosis factor α (TNF-α)."
+"Toll-like receptor signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND Toll-like receptor AND crosstalk","25549945","no","","","","","","","","","","","","","","","In addition, NOD2 expression was up-regulated by its agonist muramyl dipeptide (MDP), along with receptor interacting protein 2 (RIP2), nuclear factor κB (NFκB)-p65, inhibitor of NFκB (IκB)-α, and multiple inflammatory cytokines, including interleukin-6 (IL-6), IL-8 and tumor necrosis factor α (TNF-α)."
+"NF-kappa B signaling pathway","Toll-like receptor signaling pathway","NF-kappa B AND Toll-like receptor AND crosstalk","25888367","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND Toll-like receptor AND crosstalk","25888367","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","NF-kappa B signaling pathway","NF-kappa B AND Toll-like receptor AND crosstalk","25239812","yes","no","activating","Tlr4","Q9QX05","UNIPROT","Rela/Relb","Q7TQN4/D4A8H1","UNIPROT","Rattus norvegicus","mammary epithelial cell","","LPS","In conclusion, summary of our present results suggests that β-glucan can be considered as a potential immuno-modulator, which s with TLR4 via NF-κB subunits to initiate and regulate the innate immunity in rat MECs.","",""
+"NF-kappa B signaling pathway","Toll-like receptor signaling pathway","NF-kappa B AND Toll-like receptor AND crosstalk","25239812","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Estrogen signaling pathway","Neurotrophin AND Estrogen AND pathway","23276673","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND Estrogen AND pathway","23276673","no","","","","","","","","","","","","","","Thorough discussion of association between estrogen and BDNF, but does not describe crosstalk.","Here we focus on the mossy fiber (MF) pathway of the hippocampus, a critical pathway in normal hippocampal function, and a prime example of a location where numerous studies support an interaction between BDNF and estrogen in the rodent brain."
+"Estrogen signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND Estrogen AND pathway","23103216","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Estrogen signaling pathway","Neurotrophin AND Estrogen AND pathway","23103216","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND Estrogen AND pathway","24120943","no","","","","","","","","","","","","","","ERRa is a TF of the FNDC5 gene whose protein increases BDNF expression",""
+"Neurotrophin signaling pathway","Estrogen signaling pathway","Neurotrophin AND Estrogen AND pathway","24120943","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Estrogen signaling pathway","Neurotrophin AND Estrogen AND pathway","24650733","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND Estrogen AND pathway","15075211","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Estrogen signaling pathway","Neurotrophin AND Estrogen AND pathway","15075211","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","Estrogen signaling pathway","Neurotrophin AND Estrogen AND pathway","9744944","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND Estrogen AND pathway","9744944","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","TGF-beta signaling pathway","Neurotrophin AND TGF-beta AND crosstalk","23929714","no","","","","","","","","","","","","","","Closer to Neurotrophin to ErbB crosstalk, but study claims that CCN2 is an EGFR ligand that happens to interact with TrkA.","CCN2 interacts with the neurotrophin receptor TrkA, and EGFR/TrkA receptor crosstalk was found in response to CCN2(IV) stimulation."
+"TGF-beta signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND TGF-beta AND crosstalk","23929714","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND TGF-beta AND crosstalk","18386643","no","","","","","","","","","","","","","","PNS-CNS crosstalk",""
+"Neurotrophin signaling pathway","TGF-beta signaling pathway","Neurotrophin AND TGF-beta AND crosstalk","18386643","no","","","","","","","","","","","","","","PNS-CNS crosstalk",""
+"Neurotrophin signaling pathway","TGF-beta signaling pathway","Neurotrophin AND TGF-beta AND crosstalk","10521580","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND TGF-beta AND crosstalk","10521580","unclear","yes","inhibiting","Tgfb1","P17246","UNIPROT","Ngf","P25427","UNIPROT","Rattus norvegicus","Schwann cell","","neonatal","The results suggest that the down-regulation of NT-3 mRNA in Schwann cells at a site of peripheral nerve damage may be mediated via a cAMP-dependent pathway and possibly involve neuroma-related elevations in TGF-beta1 and GGF(2).","Mechanism seems speculative.",""
+"Neurotrophin signaling pathway","TGF-beta signaling pathway","Neurotrophin AND TGF-beta AND crosstalk","10521580","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","TGF-beta signaling pathway","Neurotrophin AND TGF-beta AND pathway","21097678","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND TGF-beta AND pathway","21097678","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND TGF-beta AND pathway","9914454","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","TGF-beta signaling pathway","Neurotrophin AND TGF-beta AND pathway","9914454","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND TGF-beta AND pathway","20155803","no","","","","","","","","","","","","","","Tieg1 gene is downstream target of both TGFB1 and NGF.","Recent studies suggest a role for members of the neurotrophin family in regulating Tieg1/Klf10 transcriptional upregulation."
+"Neurotrophin signaling pathway","TGF-beta signaling pathway","Neurotrophin AND TGF-beta AND pathway","20155803","no","","","","","","","","","","","","","","Tieg1 gene is downstream target of both TGFB1 and NGF.","Recent studies suggest a role for members of the neurotrophin family in regulating Tieg1/Klf10 transcriptional upregulation."
+"TGF-beta signaling pathway","Neurotrophin signaling pathway","Neurotrophin AND TGF-beta AND pathway","12460607","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","TGF-beta signaling pathway","Neurotrophin AND TGF-beta AND pathway","12460607","no","","","","","","","","","","","","","","NGF is member of TGFB superfamily, but crosstalk not described.",""
+"Prolactin signaling pathway","Toll-like receptor signaling pathway","Prolactin AND Toll-like receptor AND pathway","27025311","yes","yes","activating","prl","P48096","UNIPROT","F5B7Y1/F5B7Y2","F5B7Y1/F5B7Y2","UNIPROT","Salmo salar","pronephros","","","In conclusion, we found that PRL has immunostimulatory effects in SHK-1 cells of S. salar through the expression of TLR1 and TLR5M, as well as through IκBα and IL-1β.","Study published after initial curation of Gold-Standard making Prolactin to Toll-Like Receptor a crosstalking pair. Interestingly, cites Prolactin to Jak/STAT paper from Gold-Standard (20826756).",""
+"Toll-like receptor signaling pathway","Prolactin signaling pathway","Prolactin AND Toll-like receptor AND pathway","27025311","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","Wnt signaling pathway","Prolactin AND Wnt AND pathway","24407733","","","","","","","","","","","","","","","","In conclusion, fulvestrant inhibited tumor proliferation and PRL secretion of prolactinomas via ERα, and the Wnt signaling pathway was involved in this anti-tumor effect. Therefore, fulvestrant may be a potential new drug for prolactinomas."
+"Wnt signaling pathway","Prolactin signaling pathway","Prolactin AND Wnt AND pathway","24407733","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Prolactin signaling pathway","Prolactin AND Wnt AND pathway","17510243","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","Wnt signaling pathway","Prolactin AND Wnt AND pathway","17510243","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","Wnt signaling pathway","Prolactin AND Wnt AND pathway","18452624","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Prolactin signaling pathway","Prolactin AND Wnt AND pathway","18452624","no","","","","","","","","","","","","","","Does not discuss Prolactin signaling.",""
+"Wnt signaling pathway","Prolactin signaling pathway","Prolactin AND Wnt AND pathway","19034702","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","Wnt signaling pathway","Prolactin AND Wnt AND pathway","19034702","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","Wnt signaling pathway","Prolactin AND Wnt AND pathway","24643679","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Prolactin signaling pathway","Prolactin AND Wnt AND pathway","24643679","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Prolactin signaling pathway","Prolactin AND Wnt AND pathway","26191253","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","Wnt signaling pathway","Prolactin AND Wnt AND pathway","26191253","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","TGF-beta signaling pathway","Estrogen AND TGF-beta AND crosstalk","19370415","yes","yes","inhibiting","ESR1","P03372","UNIPROT","TGFB1","P01137","UNIPROT","Homo sapiens","MCF-7 cell","","","Our results indicate a permanent repression of PAI-1 by ERalpha and suggest a ligand-independent crosstalk between ERalpha and TGF-beta signaling in breast cancer cells.","",""
+"TGF-beta signaling pathway","Estrogen signaling pathway","Estrogen AND TGF-beta AND crosstalk","19370415","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Estrogen signaling pathway","Estrogen AND TGF-beta AND crosstalk","25833830","no","","","","","","","","","","","","","","Study observes less ERa phosphorylation after TGFBR2 knockdown but not enough evidence.","Furthermore, we revealed that tamoxifen-induced ERα phosphorylation at serine-118 (pS118-ERα) is abrogated and ERK1/2 phosphorylation (pERK) is completely abolished in TGFBR2 knockdown cells."
+"Estrogen signaling pathway","TGF-beta signaling pathway","Estrogen AND TGF-beta AND crosstalk","25833830","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Estrogen signaling pathway","Estrogen AND TGF-beta AND crosstalk","24104551","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","TGF-beta signaling pathway","Estrogen AND TGF-beta AND crosstalk","24104551","no","","","","","","","","","","","","","","It is unclear whether estrogen receptor loss affects intracellular TGF-B signaling.",""
+"TGF-beta signaling pathway","Estrogen signaling pathway","Estrogen AND TGF-beta AND crosstalk","24104551","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Estrogen signaling pathway","TGF-beta AND Estrogen AND pathway","16049327","yes","no","inhibiting","Esr1","P19785","UNIPROT","Smad2:Smad3","Q62432:Q8BUN5","UNIPROT","Mus musculus","mammary epithelial cell","","","This indicated co-regulation of the pathways and suggested that TGF-β could act to restrict ERα-mediated proliferation.","",""
+"Estrogen signaling pathway","TGF-beta signaling pathway","TGF-beta AND Estrogen AND pathway","16049327","no","","","","","","","","","","","","","","",""
+"TGF-beta signaling pathway","Hippo signaling pathway","TGF-beta AND Hippo AND crosstalk","25937570","no","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","TGF-beta signaling pathway","TGF-beta AND Hippo AND crosstalk","25937570","yes","no","unknown","YAP1/WWTR1","P46937/Q9GZV5","UNIPROT","SMAD2:SMAD3","Q15796:P84022","UNIPROT","Homo sapiens","HaCaT cell","","","Both these mechanisms may function to control TGFβ signaling under specific context-dependent circumstances, regulating cytoplasmic/nuclear shuttling of Smads in a cell-density-dependent manner.","",""
+"TGF-beta signaling pathway","Hippo signaling pathway","TGF-beta AND Hippo AND crosstalk","27237790","no","","","","","","","","","","","","","","SnoN (SKIL) regulates both pathways and is not assumed to be a part of the TGF-B pathway.","Consistently, SnoN enhances the transcriptional and oncogenic activities of TAZ, and reducing SnoN decreases TAZ expression as well as malignant progression of breast cancer cells."
+"Hippo signaling pathway","TGF-beta signaling pathway","TGF-beta AND Hippo AND crosstalk","27237790","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","ErbB signaling pathway","TNF AND ErbB AND crosstalk","23994140","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","TNF signaling pathway","TNF AND ErbB AND crosstalk","23994140","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","TNF signaling pathway","TNF AND ErbB AND crosstalk","21617117","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","ErbB signaling pathway","TNF AND ErbB AND crosstalk","21617117","yes","no","activating","Tnf","P06804","UNIPROT","Erbb4","Q61527","UNIPROT","Mus musculus","colonic epithelial cell","","","We conclude that TNF transactivates ErbB4 through TACE-dependent HB-EGF release, thus protecting colon epithelial cells from cytokine-induced apoptosis.","",""
+"ErbB signaling pathway","TNF signaling pathway","TNF AND ErbB AND crosstalk","24453000","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","ErbB signaling pathway","TNF AND ErbB AND crosstalk","24453000","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","ErbB signaling pathway","TNF AND ErbB AND crosstalk","9829842","no","","","","","","","","","","","","","","",""
+"ErbB signaling pathway","TNF signaling pathway","TNF AND ErbB AND crosstalk","9829842","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","HIF-1 signaling pathway","TNF AND HIF-1 AND crosstalk","25684862","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","TNF signaling pathway","TNF AND HIF-1 AND crosstalk","25684862","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","HIF-1 signaling pathway","TNF AND HIF-1 AND crosstalk","21558328","yes","yes","inhibiting","TNF","P01375","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","BEAS-2B cell","","","These results indicate that TNF-α is a cell-type specific suppressor of HIFs and suggest a novel crosstalk between stimulation by inflammatory mediators and HIF-dependent hypoxic response.","cites 20139176 which found that TNF regulated transcription of HIF1A through NF-kB signaling.",""
+"TNF signaling pathway","HIF-1 signaling pathway","TNF AND HIF-1 AND crosstalk","23023398","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","TNF signaling pathway","TNF AND HIF-1 AND crosstalk","23023398","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","TNF signaling pathway","TNF AND HIF-1 AND crosstalk","17998066","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","HIF-1 signaling pathway","TNF AND HIF-1 AND crosstalk","17998066","yes","no","activating","TNF","P01375","UNIPROT","HIF1A","Q16665","UNIPROT","Homo sapiens","HeLa cell","","","Studies using a bicistronic reporter vector containing the internal ribosomal entry site (IRES) located within the first exon of the HIF‐1α mRNA cloned between the firefly and the renilla luciferase demonstrated that TNFα enhanced the cap‐independent translation of HIF‐1α mRNA (Bert et al., 2006).","cites: 16601206 ",""
+"HIF-1 signaling pathway","TNF signaling pathway","TNF AND HIF-1 AND crosstalk","27385686","yes","yes","activating","IL6R","O18796","UNIPROT","TNF","P23563","UNIPROT","Sus scrofa","chondrocyte","BTO:0000249","ischemia","Synovial cells exposed to hypoxic chondrocyte-conditioned medium showed significant increases in IL-1β and TNF-α gene expressions and cell proliferation, which were inhibited by the IL-6 receptor blocker tocilizumab.","",""
+"TNF signaling pathway","HIF-1 signaling pathway","TNF AND HIF-1 AND crosstalk","27385686","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","HIF-1 signaling pathway","TNF AND HIF-1 AND crosstalk","25710281","no","","","","","","","","","","","","","","This seems like NF-kB to HIF-1 crosstalk when NF-kB signaling happens to be activated by TNFa ligand.","In addition, TNF-α activated HIF signaling, which required classical NF-κB activation."
+"HIF-1 signaling pathway","TNF signaling pathway","TNF AND HIF-1 AND crosstalk","25710281","no","","","","","","","","","","","","","","",""
+"HIF-1 signaling pathway","TNF signaling pathway","TNF AND HIF-1 AND crosstalk","27383646","yes","yes","inhibiting","Hif1a","O35800","UNIPROT","Tnfrsf1a","P22934","UNIPROT","Rattus norvegicus","hippocampus","","","Stabilization of HIF-1α plays a role in attenuating amplified expression IL-6R, TNFR1 and Caspase-3 in the processing of transient global ischemia.","",""
+"TNF signaling pathway","HIF-1 signaling pathway","TNF AND HIF-1 AND crosstalk","27383646","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Prolactin signaling pathway","TNF AND Prolactin AND crosstalk","16520895","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","TNF signaling pathway","TNF AND Prolactin AND crosstalk","16520895","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","TNF signaling pathway","TNF AND Prolactin AND crosstalk","26979943","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Prolactin signaling pathway","TNF AND Prolactin AND crosstalk","26979943","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","TNF signaling pathway","TNF AND Prolactin AND crosstalk","24997655","yes","yes","activating","PRLR","P16471","UNIPROT","TNF","P01375","UNIPROT","Homo sapiens","monocyte","","","Exposure to PRL in the culture increased the expression and release of TNF-α from CD14(+) monocytes, which was abolished by the PRLR gene silencing or blocking the mitogen activated protein (MAPK) pathway.","",""
+"TNF signaling pathway","Prolactin signaling pathway","TNF AND Prolactin AND crosstalk","24997655","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Prolactin signaling pathway","TNF AND Prolactin AND crosstalk","23908112","no","","","","","","","","","","","","","","",""
+"Prolactin signaling pathway","TNF signaling pathway","TNF AND Prolactin AND crosstalk","23908112","no","","","","","","","","","","","","","","Prolactin attenuates apoptosis in response to inflammatory cytokines.",""
+"TNF signaling pathway","Hippo signaling pathway","TNF AND Hippo AND crosstalk","26838548","no","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","TNF signaling pathway","TNF AND Hippo AND crosstalk","26838548","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Hippo signaling pathway","TNF AND Hippo AND crosstalk","25782587","yes","no","activating","TNF","P01375","UNIPROT","LATS2","Q9NRM7","UNIPROT","Homo sapiens","HN cell","","","LATS2 could be induced by TNF-alpha and inhibited cell proliferation and invasion by phosphorylating YAP in OSCC cells.","",""
+"Hippo signaling pathway","TNF signaling pathway","TNF AND Hippo AND crosstalk","25782587","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Toll-like receptor signaling pathway","TNF AND Toll-like receptor AND crosstalk","24758719","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","TNF signaling pathway","TNF AND Toll-like receptor AND crosstalk","24652749","no","","","","","","","","","","","","","","All TLR signaling.","By dissecting the crosstalk between the TLRs and autophagy pathways, it is uncovered that the GO-activated autophagy is regulated through the myeloid differentiation primary response gene 88 (MyD88)- and TNF receptor-associated factor 6 (TRAF6)-associated TLR-4/9 signaling pathways."
+"TNF signaling pathway","Toll-like receptor signaling pathway","TNF AND Toll-like receptor AND crosstalk","24652749","no","","","","","","","","","","","","","","All TLR signaling.",""
+"TNF signaling pathway","Toll-like receptor signaling pathway","TNF AND Toll-like receptor AND crosstalk","24035265","yes","yes","activating","TNF","P01375","UNIPROT","TLR2","O60603","UNIPROT","Homo sapiens","A-549 cell","","","Moreover, GCs cooperate with tumor necrosis factor alpha (TNF-alpha) to activate TLR2 promoter and induce TLR2 expression in lung epithelial cells through a complex regulatory machinery, which involves a 3′ nuclear factor κB (NF-κB) site, a STAT-binding element, and a 3′ glucocorticoid response element (GRE)","cites: 15143169",""
+"Toll-like receptor signaling pathway","TNF signaling pathway","TNF AND Toll-like receptor AND crosstalk","24035265","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","TNF signaling pathway","TNF AND Toll-like receptor AND crosstalk","22852877","yes","yes","activating","TLR4","O00206","UNIPROT","TNF","P01375","UNIPROT","Homo sapiens","monocyte","","","LPS stimulates TLR4-mediated activation of the NFĸB-pathway and thereby the production of TNF-α, IL-6 and IL-12p40.","",""
+"TNF signaling pathway","Toll-like receptor signaling pathway","TNF AND Toll-like receptor AND crosstalk","22852877","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Toll-like receptor signaling pathway","TNF AND Toll-like receptor AND crosstalk","24582964","no","","","","","","","","","","","","","","intercellular crosstalk",""
+"Toll-like receptor signaling pathway","TNF signaling pathway","TNF AND Toll-like receptor AND crosstalk","24582964","no","","","","","","","","","","","","","","intercellular crosstalk",""
+"Toll-like receptor signaling pathway","TNF signaling pathway","TNF AND Toll-like receptor AND crosstalk","22932793","no","","","","","","","","","","","","","","intercellular crosstalk","Anti-β(2)GPI peptide Abs induced activation of TLR4 and triggered interleukin-1 receptor-associated kinase phosphorylation and NF-κB translocation, promoting VCAM expression on endothelial cells and TNF-α release by monocytes."
+"TNF signaling pathway","Toll-like receptor signaling pathway","TNF AND Toll-like receptor AND crosstalk","22932793","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Toll-like receptor signaling pathway","TNF AND Toll-like receptor AND crosstalk","19923461","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","TNF signaling pathway","TNF AND Toll-like receptor AND crosstalk","19923461","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","TNF signaling pathway","TNF AND Toll-like receptor AND crosstalk","23790335","no","","","","","","","","","","","","","","correlation; not enough evidence","There was certain correlation between the protein expression of TLR4 and the increased serum titer of 24-hour urine protein excretion, serum creatinine, CRP and TNF-α."
+"TNF signaling pathway","Toll-like receptor signaling pathway","TNF AND Toll-like receptor AND crosstalk","23790335","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Jak-STAT signaling pathway","TNF AND Jak-STAT AND crosstalk","23185365","no","","","","","","","","","","","","","","",""
+"TNF signaling pathway","Jak-STAT signaling pathway","TNF AND Jak-STAT AND crosstalk","27051585","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Adipocytokine signaling pathway","VEGF AND Adipocytokine AND pathway","27345723","no","","","","","","","","","","","","","","",""
+"Adipocytokine signaling pathway","VEGF signaling pathway","VEGF AND Adipocytokine AND pathway","27345723","yes","yes","activating","LEP","P41159","UNIPROT","VEGFC","P49767","UNIPROT","Homo sapiens","chondrosarcoma cell","","","Our study is the first to describe the mechanism of leptin-promoted lymphangiogenesis by upregulating VEGF-C expression in chondrosarcomas.","",""
+"HIF-1 signaling pathway","Estrogen signaling pathway","HIF-1 AND Estrogen AND pathway","19084502","yes","no","activating","HIF1A","Q16665","UNIPROT","ESR1","P03372","UNIPROT","Homo sapiens","HEK-293 cell","","","These results provide evidence that hypoxia may stimulate yet unknown factor(s), which can further stimulate ERalpha signal transduction pathways","",""
+"Hippo signaling pathway","ErbB signaling pathway","Hippo AND ErbB AND pathway","20713513","no","","","","","","","","","","","","","","",""
+"Hippo signaling pathway","Insulin signaling pathway","Hippo AND Insulin AND pathway","22609549","yes","yes","activating","yki","Q45VV3","UNIPROT","","","","Drosophila melanogaster","","","","Yki activation causes transcriptional changes in genes encoding components of the IIS pathway.","",""
+"TGF-beta signaling pathway","Hippo signaling pathway","Hippo AND Insulin AND pathway","22153608","yes","no","activating","SMAD3:SMAD4","P84022:Q13485","UNIPROT","YAP1/WWTR1","P46937/Q9GZV5","UNIPROT","Homo sapiens","embryonic stem cell","",""," Human ESC pluripotency, which relies on TGF-β–Smad signaling 63 and 64, is dependent on TAZ activity [65].","",""
+"TNF signaling pathway","Jak-STAT signaling pathway","TNF AND Jak-STAT AND pathway","23107828","yes","no","activating","TNFRSF12A","Q9NP84","UNIPROT","STAT1","P42224","UNIPROT","Homo sapiens","WiDr cell","","","Significantly, we found that TWEAK alone can induce STAT1 phosphorylation in WiDr tumor cells.","",""
+"VEGF signaling pathway","TGF-beta signaling pathway","VEGF AND TGF-beta AND crosstalk","17088559","yes","","inhibiting","TGFB1","P18341","UNIPROT","VEGFA","P15691","UNIPROT","Bos taurus","capillary endothelial cell","","","Thus, cross-talk between TGF-beta1 and VEGF signaling converts VEGF/flk-1-activated p38(MAPK) into a proapoptotic signal.","",""
+"Toll-like receptor signaling pathway","Estrogen signaling pathway","Toll-like receptor AND Estrogen AND crosstalk","22960279","no","","","","","","","","","","","","","","other direction",""
+"Toll-like receptor signaling pathway","Estrogen signaling pathway","Toll-like receptor AND Estrogen AND crosstalk","25887269","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Toll-like receptor signaling pathway","Toll-like receptor AND Estrogen AND crosstalk","25887269","no","","","","","","","","","","","","","","Daidzein targets TLR pathway to attenuate LPS-induced lung injury.",""
+"Toll-like receptor signaling pathway","Estrogen signaling pathway","Toll-like receptor AND Estrogen AND pathway","24604861","no","","","","","","","","","","","","","","",""
+"Estrogen signaling pathway","Toll-like receptor signaling pathway","Toll-like receptor AND Estrogen AND pathway","24604861","unclear","yes","activating","estradiol","hormone","hormone","TLR4/MYD88","C4PCF3/A5HNF6","UNIPROT","Gallus gallus","vagina","","","The expression of TLR4, its adaptor molecule, namely, myeloid differentiation factor 88 (MyD88) or Toll-interleukin 1 receptor domain-containing adaptor-inducing IFN-β (TRIF), and transcriptional factors, namely, cFos and cJun, declined in molting hens compared with that in laying hens, and were upregulated by estradiol.","Estradiol upregulates TLR signaling, but unclear whether this is estrogen signaling or just a function of estradiol.",""
+"Toll-like receptor signaling pathway","Hippo signaling pathway","Toll-like receptor AND Hippo AND pathway","26824654","yes","no","activating","pll","Q05652","UNIPROT","Cka","Q9VLT9","UNIPROT","Drosophila melanogaster","","","","Furthermore, Gram-positive bacteria acutely activate Hippo-Yorkie signaling in fat bodies via the Toll-Myd88-Pelle cascade through Pelle-mediated phosphorylation and degradation of the Cka subunit of the Hippo-inhibitory STRIPAK PP2A complex.","",""
+"Toll-like receptor signaling pathway","VEGF signaling pathway","Toll-like receptor AND VEGF AND pathway","26362177","no","","","","","","","","","","","","","","Correlation; unclear what effect TLR4 has on VEGFC expression.","HA increased expression of vascular endothelial cell growth factor-C in macrophages. Vascular endothelial cell growth factor-C expression and LYVE-1-positive lymphatic area was significantly lower in the UUO-kidney from TLR4 null mice than that from TLR4 wild-type mice."
+"VEGF signaling pathway","Toll-like receptor signaling pathway","Toll-like receptor AND VEGF AND pathway","26362177","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Toll-like receptor signaling pathway","Wnt AND Toll-like receptor AND crosstalk","27450445","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","Wnt signaling pathway","Wnt AND Toll-like receptor AND crosstalk","27450445","no","","","","","","","","","","","","","","",""
+"Wnt signaling pathway","Toll-like receptor signaling pathway","Wnt AND Toll-like receptor AND crosstalk","19809894","no","","","","","","","","","","","","","","",""
+"Toll-like receptor signaling pathway","Wnt signaling pathway","Wnt AND Toll-like receptor AND crosstalk","19809894","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","ErbB signaling pathway","VEGF AND ErbB AND crosstalk","23518595","no","","","","","","","","","","","","","","other direction",""
+"VEGF signaling pathway","ErbB signaling pathway","VEGF AND ErbB AND crosstalk","23251664","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","ErbB signaling pathway","VEGF AND ErbB AND crosstalk","17579068","no","","","","","","","","","","","","","","study discusses efficacy of vaccines for inhibiting tumor growth",""
+"VEGF signaling pathway","GnRH signaling pathway","VEGF AND GnRH AND pathway","26377185","no","","","","","","","","","","","","","","study about the inhibitory effects of a dopamine agonist on VEGF; GnRH mentioned in passing",""
+"VEGF signaling pathway","GnRH signaling pathway","VEGF AND GnRH AND pathway","18258233","no","","","","","","","","","","","","","","expression analysis",""
+"VEGF signaling pathway","GnRH signaling pathway","VEGF AND GnRH AND pathway","25838743","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","GnRH signaling pathway","VEGF AND GnRH AND pathway","21664414","no","","","","","","","","","","","","","","Absence of PROK2 signaling due to knockout is accompanied by a reduction of GnRH-expressing cells.","However, both prok2 and prokr2 knockout mice showed disruption of the neurogenesis of their olfactory bulbs (OB) accompanied by a dramatic reduction of the GnRH-expressing cells in the median preoptic area as well as absence of GnRH neural projections in the medium eminence (Pitteloud, Zhang et al. 2007)."
+"VEGF signaling pathway","GnRH signaling pathway","VEGF AND GnRH AND pathway","21062912","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","GnRH signaling pathway","VEGF AND GnRH AND pathway","22998140","no","","","","","","","","","","","","","","Review on signaling pathway imbalance in ischemic mice",""
+"VEGF signaling pathway","GnRH signaling pathway","VEGF AND GnRH AND pathway","26418982","no","","","","","","","","","","","","","","expression analysis",""
+"VEGF signaling pathway","HIF-1 signaling pathway","VEGF AND HIF-1 AND crosstalk","20544853","no","","","","","","","","","","","","","","other direction",""
+"VEGF signaling pathway","HIF-1 signaling pathway","VEGF AND HIF-1 AND crosstalk","25330803","no","","","","","","","","","","","","","","other direction",""
+"VEGF signaling pathway","Jak-STAT signaling pathway","VEGF AND Jak-STAT AND pathway","25628937","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Jak-STAT signaling pathway","VEGF AND Jak-STAT AND pathway","22762031","no","","","","","","","","","","","","","","other direction",""
+"VEGF signaling pathway","Jak-STAT signaling pathway","VEGF AND Jak-STAT AND pathway","21170078","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Jak-STAT signaling pathway","VEGF AND Jak-STAT AND pathway","24101550","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Neurotrophin signaling pathway","VEGF AND Neurotrophin AND crosstalk","22562556","no","","","","","","","","","","","","","","other direction",""
+"VEGF signaling pathway","Neurotrophin signaling pathway","VEGF AND Neurotrophin AND pathway","23337506","no","","","","","","","","","","","","","","other direction",""
+"VEGF signaling pathway","Neurotrophin signaling pathway","VEGF AND Neurotrophin AND pathway","23343527","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Neurotrophin signaling pathway","VEGF AND Neurotrophin AND pathway","18566344","no","","","","","","","","","","","","","","",""
+"Neurotrophin signaling pathway","VEGF signaling pathway","VEGF AND Neurotrophin AND pathway","18566344","yes","no","inhibiting","NGFR","P08138","UNIPROT","VEGFA","P15692","UNIPROT","Homo sapiens","HUVEC cell","","","In fact, p75(NTR) depresses the VEGF-A/Akt/eNOS/NO pathway and additionally reduces the mRNA levels of ITGB1 [beta (1) integrin], BIRC5 (survivin), PTTG1 (securin) and VEZF1.","",""
+"VEGF signaling pathway","Prolactin signaling pathway","VEGF AND Prolactin AND pathway","23729680","","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Prolactin signaling pathway","VEGF AND Prolactin AND pathway","21406548","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Prolactin signaling pathway","VEGF AND Prolactin AND pathway","21406548","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Prolactin signaling pathway","VEGF AND Prolactin AND pathway","22199350","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","TNF signaling pathway","VEGF AND TNF AND crosstalk","23922887","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","TNF signaling pathway","VEGF AND TNF AND crosstalk","26900328","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Wnt signaling pathway","VEGF AND Wnt AND crosstalk","25955104","no","","","","","","","","","","","","","","",""
+"VEGF signaling pathway","Wnt signaling pathway","VEGF AND Wnt AND crosstalk","25355597","no","","","","","","","","","","","","","","TGF-beta and Wnt crosstalk",""
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