tokens: In multivariate analysis including risk factors significant in univariate analysis , female sex ( HR 1.87 , 95 % CI 1.23 - 2.86 , p=0.004 ) , CNS - involvement ( HR 2.24 , 95 % CI 1.03 - 4.88 , p=0.042 ) , lymphoblastic lymphoma ( HR 2.60 , 95 % CI 1.69 - 3.97 , p<0.001 ) , and cancer - predisposing condition ( HR 11.2 , 95 % CI 5.52 - 22.75 , p<0.001 ) retained an independent risk .