tokens: The mean per - patient annual direct medical cost of illness was estimated at between $ 3320 ( SMA type III , Italy ) and $ 324,410 ( SMA type I , USA ) , mean per - patient annual direct non - medical cost between $ 25,880 ( SMA types I - III , Spain ) and $ 136,800 ( SMA type I , Sweden ) , and mean per - patient annual indirect cost between $ 9440 ( SMA type I , Germany ) and $ 74,910 ( SMA type II , Australia ) .