tokens: However , parental consanguinity showed protective impact on the onset at early age of disease [ OD = 0.44 ( 0.25 - 0.77 ) , p - value = 0.00 ] while , a family history of cancer increased the risk of cardiotoxicity [ OD = 2.46 ( 1.15 - 5.24 ) , p - value = 0.02 ] .