MRR NOUN B-AC
, PUNCT O
mortality NOUN B-LF
rate NOUN I-LF
ratio NOUN I-LF
; PUNCT O
TBI PROPN B-AC
, PUNCT O
traumatic ADJ B-LF
brain NOUN I-LF
injury NOUN I-LF
. PUNCT O

HPC PROPN B-AC
, PUNCT O
hippocampus NOUN B-LF
; PUNCT O
mOFC NOUN O
, PUNCT O
medial ADJ O
OFC PROPN B-AC
; PUNCT O
OFC PROPN B-AC
, PUNCT O
orbitofrontal ADJ B-LF
cortex NOUN I-LF
; PUNCT O
PPI NOUN B-AC
, PUNCT O
psychophysiological ADJ B-LF
interaction NOUN I-LF
. PUNCT O

In ADP O
addition NOUN O
to ADP O
the DET O
effects NOUN O
on ADP O
cell NOUN O
growth NOUN O
and CCONJ O
migration NOUN O
, PUNCT O
the DET O
18β NOUN B-AC
- PUNCT B-AC
GA NOUN B-AC
- PUNCT B-AC
d NOUN B-AC
used VERB O
in ADP O
this DET O
study NOUN O
could AUX O
also ADV O
up ADV O
- PUNCT O
regulate VERB O
expression NOUN O
of ADP O
aquaporin-3 NOUN B-LF
( PUNCT O
AQP-3 NOUN B-AC
) PUNCT O
in ADP O
fibroblasts NOUN O
and CCONJ O
keratinocytes NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
HC PROPN B-AC
, PUNCT O
C NOUN B-LF
- PUNCT I-LF
terminal ADJ I-LF
receptor NOUN I-LF
- PUNCT I-LF
binding VERB I-LF
domain NOUN I-LF
; PUNCT O
ka NOUN B-AC
, PUNCT O
association NOUN B-LF
rate NOUN I-LF
constant ADJ I-LF
; PUNCT O
kd NOUN B-AC
, PUNCT O
dissociation NOUN B-LF
rate NOUN I-LF
constant ADJ I-LF
; PUNCT O
KD NOUN B-AC
, PUNCT O
equilibrium NOUN B-LF
dissociation NOUN I-LF
constant ADJ I-LF
; PUNCT O
ND PROPN B-AC
, PUNCT O
nanodisc NOUN B-LF
; PUNCT O
Syt PROPN B-AC
, PUNCT O
synaptotagmin NOUN B-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF

LL PROPN B-AC
: PUNCT O
lower ADJ B-LF
limit NOUN I-LF
, PUNCT O
UL PROPN B-AC
: PUNCT O
upper ADJ B-LF
limit NOUN I-LF
. PUNCT O

Transcriptome NOUN O
analysis NOUN O
revealed VERB O
up NOUN O
- PUNCT O
regulation NOUN O
of ADP O
G1 PROPN O
/ SYM O
S PROPN O
phase NOUN O
transition NOUN O
genes NOUN O
( PUNCT O
myelocytomatosis NOUN B-LF
oncogene NOUN I-LF
cellular ADJ I-LF
homolog NOUN I-LF
[ PUNCT O
Myc PROPN B-AC
] PUNCT O
, PUNCT O
cyclin NOUN O
D1/3 PROPN O
, PUNCT O
chromatin NOUN B-LF
licensing NOUN I-LF
and CCONJ I-LF
DNA NOUN I-LF
replication NOUN I-LF
factor NOUN I-LF
1 NUM I-LF
[ PUNCT O
Cdt1 PROPN B-AC
] PUNCT O
) PUNCT O
, PUNCT O
concomitant ADJ O
with ADP O
increased VERB O
phosphorylation NOUN O
of ADP O
the DET O
retinoblastoma NOUN B-LF
( PUNCT O
RB PROPN B-AC
) PUNCT O
protein NOUN O
by ADP O
cyclin NOUN O
- PUNCT O
dependent ADJ O
kinase NOUN O
( PUNCT O
CDK PROPN B-AC
) PUNCT O
4/6 NUM O
and CCONJ O
increased VERB O
G1 PROPN O
- PUNCT O
S PROPN O
progression NOUN O
. PUNCT O

Functional ADJ O
status NOUN O
was AUX O
measured VERB O
using VERB O
the DET O
validated VERB O
MDS PROPN B-AC
- PUNCT O
ADL PROPN B-AC
scale NOUN O
, PUNCT O
which PRON O
aggregates VERB O
7 NUM O
activities NOUN B-LF
of ADP I-LF
daily ADJ I-LF
living NOUN I-LF
( PUNCT O
ADL PROPN B-AC
) PUNCT O
items NOUN O
into ADP O
a DET O
28 NUM O
- PUNCT O
point NOUN O
scale NOUN O
with ADP O
0 NUM O
indicating VERB O
independence NOUN O
and CCONJ O
28 NUM O
indicating VERB O
total ADJ O
dependence NOUN O
[ PUNCT O
18,19 NUM O
] PUNCT O
. PUNCT O

We PRON O
screened VERB O
primary ADJ O
RNA NOUN O
samples NOUN O
from ADP O
human ADJ O
blood NOUN O
, PUNCT O
colon NOUN O
, PUNCT O
placenta NOUN O
, PUNCT O
and CCONJ O
testis NOUN O
by ADP O
5′ NUM O
rapid ADJ B-LF
amplification NOUN I-LF
of ADP I-LF
cDNA NOUN I-LF
ends NOUN I-LF
( PUNCT O
RACE NOUN B-AC
) PUNCT O
and CCONJ O
could AUX O
not PART O
confirm VERB O
this DET O
TSS NOUN B-AC
in ADP O
these DET O
tissues NOUN O
. PUNCT O

n NOUN O
, PUNCT O
number NOUN O
of ADP O
patients NOUN O
in ADP O
subgroup NOUN O
of ADP O
interest NOUN O
. PUNCT O
aOR PROPN B-AC
, PUNCT O
adjusted VERB B-LF
odds NOUN I-LF
ratios NOUN I-LF
— PUNCT O
adjustment NOUN O
described VERB O
in ADP O
footnotes NOUN O
for ADP O
Table NOUN O
3 NUM O
. PUNCT O

The DET O
proteins NOUN O
Raptor PROPN O
and CCONJ O
Rictor PROPN B-AC
( PUNCT O
rapamycin NOUN B-LF
- ADJ I-LF
insensitive ADJ I-LF
companion NOUN I-LF
of ADP I-LF
mTOR PROPN I-LF
) PUNCT O
are AUX O
mutually ADV O
- ADJ O
exclusive ADJ O
binding VERB O
partners NOUN O
for ADP O
TOR PROPN B-AC
and CCONJ O
define VERB O
the DET O
TORC1 NOUN O
and CCONJ O
TORC2 PROPN O
complexes NOUN O
, PUNCT O
respectively ADV O
[ X O
3 NUM O
] PUNCT O
. PUNCT O

It PRON O
is AUX O
quite ADV O
plausible ADJ O
that SCONJ O
AMPK PROPN B-AC
cooperates VERB O
with ADP O
FOrkhead PROPN B-LF
boX PROPN I-LF
O PROPN I-LF
( PUNCT O
FOXO)/DAF-16 PROPN B-AC
to PART O
maintain VERB O
this DET O
state NOUN O
throughout ADP O
the DET O
diapause NOUN O
and/or CCONJ O
in ADP O
other ADJ O
situations NOUN O
of ADP O
energy NOUN O
stress NOUN O
. PUNCT O

Full ADJ O
model NOUN O
( PUNCT O
red ADJ O
curve NOUN O
) PUNCT O
includes VERB O
the DET O
diabetes NOUN O
risk NOUN O
score NOUN O
, PUNCT O
FPG PROPN B-AC
, PUNCT O
A1C PROPN O
and CCONJ O
FLI NOUN B-AC
. PUNCT O
The DET O
blue ADJ O
curves NOUN O
correspond VERB O
to ADP O
the DET O
same ADJ O
model NOUN O
after ADP O
the DET O
exclusion NOUN O
of ADP O
one NUM O
of ADP O
the DET O
components NOUN O
: PUNCT O
diabetes NOUN O
risk NOUN O
score NOUN O
( PUNCT O
A NOUN O
) PUNCT O
, PUNCT O
FPG PROPN B-AC
( PUNCT O
B NOUN O
) PUNCT O
, PUNCT O
A1C PROPN O
( PUNCT O
C NOUN O
) PUNCT O
and CCONJ O
FLI NOUN B-AC
( PUNCT O
D NOUN O
) PUNCT O
. PUNCT O
FLI NOUN B-AC
: PUNCT O
fatty ADJ B-LF
liver NOUN I-LF
index NOUN I-LF
. PUNCT O

Insets NOUN O
show VERB O
representative ADJ O
examples NOUN O
of ADP O
RFP NOUN O
- PUNCT O
positive ADJ O
nuclei NOUN O
( PUNCT O
outlined VERB O
by ADP O
dashed VERB O
yellow ADJ O
lines NOUN O
) PUNCT O
that PRON O
are AUX O
either CCONJ O
Ki67 NOUN O
- PUNCT O
positive ADJ O
( PUNCT O
yellow ADJ O
arrows NOUN O
, PUNCT O
see VERB O
also ADV O
main ADJ O
panels NOUN O
) PUNCT O
or CCONJ O
- PUNCT O
negative ADJ O
( PUNCT O
yellow ADJ O
arrowheads NOUN O
) PUNCT O
; PUNCT O
scale NOUN O
bars NOUN O
, PUNCT O
5 NUM O
μm NOUN O
. PUNCT O
( PUNCT O
K NOUN O
) PUNCT O
Quantification NOUN O
of ADP O
Ki67- NOUN O
and CCONJ O
RFP NOUN O
- PUNCT O
positive ADJ O
cells NOUN O
in ADP O
the DET O
cortical ADJ O
wall NOUN O
( PUNCT O
total ADJ O
) PUNCT O
, PUNCT O
VZ PROPN B-AC
and CCONJ O
SVZ PROPN B-AC
, PUNCT O
expressed VERB O
as ADP O
percentage NOUN O
of ADP O
all DET O
RFP NOUN O
- PUNCT O
positive ADJ O
cells NOUN O
in ADP O
the DET O
cortical ADJ O
wall NOUN O
( PUNCT O
200 NUM O
- PUNCT O
μm NOUN O
wide ADJ O
area NOUN O
) PUNCT O
, PUNCT O
upon SCONJ O
control NOUN O
( PUNCT O
Con PROPN O
, PUNCT O
white ADJ O
) PUNCT O
and CCONJ O
Pax6 PROPN O
( PUNCT O
black ADJ O
) PUNCT O
electroporation NOUN O
. PUNCT O
( PUNCT O
E PROPN O
, PUNCT O
G PROPN O
, PUNCT O
H NOUN O
, PUNCT O
K NOUN O
) PUNCT O
Mean NOUN O
of ADP O
nine NUM O
embryos NOUN O
( PUNCT O
three NUM O
independent ADJ O
experiments NOUN O
with ADP O
three NUM O
embryos NOUN O
each PRON O
) PUNCT O
; PUNCT O
error NOUN O
bars NOUN O
, PUNCT O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean NOUN I-LF
( PUNCT O
SEM PROPN B-AC
) PUNCT O
. PUNCT O
* PUNCT O
p NOUN O
< X O
0.05 NUM O
, PUNCT O
* PUNCT O
* PUNCT O
p NOUN O
< X O
0.01 NUM O
, PUNCT O
* PUNCT O
* PUNCT O
* PUNCT O
p NOUN O
< X O
0.001 NUM O
. PUNCT O

HbA1c NOUN B-AC
, PUNCT O
glycated ADJ B-LF
haemoglobin NOUN I-LF
; PUNCT O
HOMA PROPN B-AC
- PUNCT B-AC
B PROPN B-AC
, PUNCT O
homeostatic ADJ B-LF
model NOUN I-LF
assessment NOUN I-LF
of ADP I-LF
beta NOUN I-LF
cell NOUN I-LF
function NOUN I-LF
; PUNCT O
HOMA PROPN B-AC
- PUNCT B-AC
IR PROPN B-AC
, PUNCT O
homeostatic ADJ B-LF
model NOUN I-LF
assessment NOUN I-LF
of ADP I-LF
insulin NOUN I-LF
resistance NOUN I-LF
. PUNCT O

A DET O
major ADJ O
goal NOUN O
of ADP O
quantitative ADJ O
immunology NOUN O
is AUX O
to PART O
be AUX O
able ADJ O
to PART O
detect VERB O
and CCONJ O
predict VERB O
T PROPN B-LF
cell NOUN I-LF
receptor NOUN I-LF
( PUNCT O
TCR NOUN B-AC
) PUNCT O
specificity NOUN O
from ADP O
high ADJ B-LF
- PUNCT I-LF
throughput NOUN I-LF
sequencing NOUN I-LF
of ADP I-LF
TCR NOUN I-LF
repertoires NOUN I-LF
( PUNCT O
RepSeq PROPN B-AC
) PUNCT O
data NOUN O
. PUNCT O

We PRON O
evaluated VERB O
the DET O
association NOUN O
between ADP O
drought NOUN O
at ADP O
the DET O
date NOUN O
of ADP O
birth NOUN O
and CCONJ O
receipt NOUN O
of ADP O
bacillus NOUN B-LF
Calmette PROPN I-LF
– PUNCT I-LF
Guérin PROPN I-LF
( PUNCT O
BCG PROPN B-AC
) PUNCT O
, PUNCT O
diphtheria NOUN B-LF
– PUNCT I-LF
pertussis NOUN I-LF
– PUNCT I-LF
tetanus NOUN I-LF
( PUNCT O
DPT PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
polio NOUN O
vaccinations NOUN O
, PUNCT O
and CCONJ O
the DET O
association NOUN O
between ADP O
drought NOUN O
at ADP O
12 NUM O
months NOUN O
of ADP O
age NOUN O
and CCONJ O
receipt NOUN O
of ADP O
measles NOUN O
vaccination NOUN O
. PUNCT O

Therefore ADV O
, PUNCT O
in ADP O
this DET O
study NOUN O
we PRON O
have AUX O
created VERB O
a DET O
vaccine NOUN O
delivery NOUN O
platform NOUN O
for ADP O
synthetic ADJ O
minimal ADJ O
immunogens NOUN O
that PRON O
would AUX O
improve VERB O
their PRON O
immunogenicity NOUN O
and CCONJ O
can AUX O
be AUX O
linked VERB O
directly ADV O
to ADP O
potent ADJ O
Toll PROPN B-LF
- PUNCT I-LF
like ADJ I-LF
receptor NOUN I-LF
( PUNCT O
TLR PROPN B-AC
) PUNCT O
7/8 NUM O
agonist NOUN O
adjuvants NOUN O
[ PUNCT O
35 NUM O
] PUNCT O
. PUNCT O

The DET O
Cochrane PROPN O
’s PART O
Q NOUN O
- NOUN O
test NOUN O
was AUX O
performed VERB O
and CCONJ O
I2 PROPN O
statistics NOUN O
were AUX O
obtained VERB O
, PUNCT O
using VERB O
a DET O
predefined VERB O
significance NOUN O
threshold NOUN O
of ADP O
0.05.If NUM O
P≥0.05 NUM O
, PUNCT O
it PRON O
was AUX O
considered VERB O
that SCONJ O
there PRON O
was AUX O
no DET O
heterogeneity NOUN O
between ADP O
studies NOUN O
; PUNCT O
and CCONJ O
a DET O
fixed ADJ B-LF
effects NOUN I-LF
model NOUN I-LF
( PUNCT O
FEM PROPN B-AC
) PUNCT O
was AUX O
used VERB O
for ADP O
the DET O
analysis NOUN O
. PUNCT O

HR NOUN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT O
CI PROPN O
, PUNCT O
confidence NOUN O
interval NOUN O
; PUNCT O
NA PROPN O
, PUNCT O
not PART O
adopted VERB O
; PUNCT O
NS PROPN O
, PUNCT O
not PART O
significant ADJ O
; PUNCT O
ALBI PROPN B-AC
, PUNCT O
Albumin PROPN B-LF
- PUNCT I-LF
Bilirubin PROPN I-LF
. PUNCT O

On ADP O
the DET O
other ADJ O
hand NOUN O
, PUNCT O
A NOUN B-AC
- PUNCT B-AC
to ADP B-AC
- PUNCT B-AC
I NOUN B-AC
RNA NOUN B-AC
editing NOUN B-AC
is AUX O
catalyzed VERB O
by ADP O
adenosine NOUN B-LF
deaminase NOUN I-LF
acting VERB I-LF
on ADP I-LF
RNA NOUN I-LF
( PUNCT O
ADAR PROPN B-AC
) PUNCT O
enzymes NOUN O
, PUNCT O
ADAR1 PROPN O
and CCONJ O
ADAR2 PROPN O
, PUNCT O
that PRON O
specifically ADV O
bind VERB O
to ADP O
double ADJ B-LF
- PUNCT I-LF
stranded ADJ I-LF
RNA NOUN I-LF
( PUNCT O
dsRNA NOUN B-AC
) PUNCT O
[ PUNCT O
17,18 NUM O
] PUNCT O
. PUNCT O

OR PROPN B-AC
, PUNCT O
odds NOUN B-LF
ratio NOUN I-LF
; PUNCT O
CI PROPN O
, PUNCT O
confidence NOUN O
interval NOUN O
; PUNCT O
Lapa PROPN O
, PUNCT O
laparoscopy NOUN O
; PUNCT O
CRT PROPN B-AC
, PUNCT O
chemoradiotherapy NOUN B-LF
. PUNCT O

The DET O
definition NOUN O
of ADP O
an DET O
iMotif PROPN B-AC
depends VERB O
on ADP O
the DET O
minimum ADJ O
number NOUN O
of ADP O
common ADJ O
partners NOUN O
required VERB O
in ADP O
order NOUN O
to PART O
consider VERB O
the DET O
given VERB O
binary ADJ O
protein NOUN O
interactions NOUN O
mediated VERB O
through ADP O
a DET O
common ADJ O
interacting VERB B-LF
motif NOUN I-LF
. PUNCT O

All DET O
the DET O
genes NOUN O
in ADP O
the DET O
pathway NOUN O
are AUX O
known VERB O
to ADP O
be AUX O
coregulated VERB O
by ADP O
the DET O
same ADJ O
transcription NOUN O
factors NOUN O
, PUNCT O
but CCONJ O
we PRON O
observed VERB O
drastically ADV O
different ADJ O
dynamic ADJ O
responses NOUN O
for ADP O
enzymes NOUN O
upstream ADJ O
and CCONJ O
immediately ADV O
downstream ADJ O
of ADP O
the DET O
key ADJ O
control NOUN O
point NOUN O
— PUNCT O
the DET O
intermediate ADJ O
metabolite NOUN O
α NOUN B-LF
- NOUN I-LF
isopropylmalate NOUN I-LF
( PUNCT O
αIPM PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
couples VERB O
metabolic ADJ O
activity NOUN O
to ADP O
transcriptional ADJ O
regulation NOUN O
. PUNCT O

An DET O
interesting ADJ O
finding NOUN O
during ADP O
this PRON O
study NOUN O
was AUX O
that SCONJ O
a DET O
higher ADJ O
dose NOUN O
of ADP O
LA PROPN B-AC
( PUNCT O
10 NUM O
μM NOUN O
) PUNCT O
did AUX O
not PART O
elicit VERB O
a DET O
recovery NOUN O
response NOUN O
as ADP O
compared VERB O
to ADP O
1 NUM O
μM NOUN O
of ADP O
LA PROPN B-AC
. PUNCT O
One NUM O
explanation NOUN O
for ADP O
this PRON O
is AUX O
that SCONJ O
LA PROPN B-AC
at ADP O
higher ADJ O
doses NOUN O
is AUX O
fragmented VERB O
into ADP O
smaller ADJ O
peptide NOUN O
fragments NOUN O
that SCONJ O
inhibit VERB O
the DET O
reparative ADJ O
effects NOUN O
of ADP O
LA PROPN B-AC
. PUNCT O
Indeed ADV O
, PUNCT O
analysis NOUN O
of ADP O
the DET O
bathing NOUN O
solution NOUN O
containing VERB O
LA PROPN B-AC
revealed VERB O
at ADP O
least ADV O
4 NUM O
fragments NOUN O
of ADP O
LA PROPN B-AC
were AUX O
present ADJ O
, PUNCT O
and CCONJ O
application NOUN O
of ADP O
a DET O
higher ADJ O
dose NOUN O
of ADP O
F2 PROPN B-AC
( PUNCT O
10 NUM O
μM NOUN O
) PUNCT O
in ADP O
particular ADJ O
inhibited VERB O
the DET O
recovery NOUN O
response NOUN O
induced VERB O
by ADP O
LA PROPN B-AC
. PUNCT O
We PRON O
also ADV O
determined VERB O
that SCONJ O
F1 PROPN B-AC
and CCONJ O
F2 PROPN B-AC
are AUX O
formed VERB O
by ADP O
the DET O
brush NOUN O
border NOUN O
enzyme NOUN O
aminopeptidase NOUN B-LF
M PROPN I-LF
when SCONJ O
AM PROPN B-AC
was AUX O
incubated VERB O
with ADP O
LA PROPN B-AC
in ADP O
vitro ADV O
. PUNCT O

A DET O
forward ADJ O
genetic ADJ O
screen NOUN O
for ADP O
immunocompromised ADJ O
mutants NOUN O
demonstrated VERB O
a DET O
requirement NOUN O
for ADP O
a DET O
conserved VERB O
p38 NOUN O
mitogen NOUN B-LF
- PUNCT I-LF
activated VERB I-LF
protein NOUN I-LF
kinase NOUN I-LF
( PUNCT O
MAPK PROPN B-AC
) PUNCT O
pathway NOUN O
in ADP O
C. PROPN O
elegans NOUN O
immunity NOUN O
[ PUNCT O
5 NUM O
] PUNCT O
. PUNCT O

H. PROPN O
dujardini PROPN O
had VERB O
40 NUM O
UDP PROPN B-AC
glycosyltransferase NOUN O
genes NOUN O
, PUNCT O
29 NUM O
of ADP O
which PRON O
were AUX O
classified VERB O
as ADP O
glucuronosyltransferase NOUN O
( PUNCT O
UGT PROPN B-AC
, PUNCT O
K00699 NOUN O
) PUNCT O
by ADP O
Kyoto PROPN B-LF
Encyclopedia PROPN I-LF
of ADP I-LF
Genes PROPN I-LF
and CCONJ I-LF
Genomes PROPN I-LF
( PUNCT O
KEGG PROPN B-AC
) PUNCT O
ORTHOLOG PROPN O
mapping NOUN O
with ADP O
the DET O
KEGG PROPN B-LF
Automatic PROPN I-LF
Annotation PROPN I-LF
Server PROPN I-LF
( PUNCT O
KAAS PROPN B-AC
) PUNCT O
[ PUNCT O
70 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
of ADP O
these DET O
27 NUM O
were AUX O
HGT PROPN B-AC
candidates NOUN O
. PUNCT O

ALT PROPN B-AC
: PUNCT O
alanine NOUN B-LF
aminotransferase NOUN I-LF
, PUNCT O
AST PROPN B-AC
: PUNCT O
aspartate NOUN B-LF
aminotransferase NOUN I-LF
, PUNCT O
HDL NOUN O
- PUNCT O
C PROPN O
: PUNCT O
high ADJ O
- PUNCT O
density NOUN O
lipoprotein NOUN O
cholesterol NOUN O
, PUNCT O
HFD NOUN B-AC
: PUNCT O
high ADJ B-LF
- PUNCT I-LF
fat NOUN I-LF
diet NOUN I-LF
, PUNCT O
LDL NOUN O
- PUNCT O
C PROPN O
: PUNCT O
low ADJ O
- PUNCT O
density NOUN O
lipoprotein NOUN O
cholesterol NOUN O
, PUNCT O
VLDL NOUN O
- PUNCT O
C PROPN O
: PUNCT O
very ADV O
- PUNCT O
low ADJ O
- PUNCT O
density NOUN O
lipoprotein NOUN O
cholesterol NOUN O
. PUNCT O

( PUNCT O
A X O
) PUNCT O
Mouse NOUN B-LF
brain NOUN I-LF
capillary ADJ I-LF
endothelial ADJ I-LF
cells NOUN I-LF
( PUNCT O
mBECs NOUN B-AC
) PUNCT O
are AUX O
isolated VERB O
on ADP O
day NOUN O
-4 NUM O
, PUNCT O
while SCONJ O
both CCONJ O
rat NOUN O
BECs NOUN B-AC
( PUNCT O
rBECs NOUN B-AC
) PUNCT O
and CCONJ O
porcine NOUN O
BECs NOUN B-AC
( PUNCT O
pBECs NOUN B-AC
) PUNCT O
are AUX O
isolated VERB O
on ADP O
day NOUN O
-3 NUM O
. PUNCT O

In ADP O
Ube3A PROPN O
deficient ADJ O
mice NOUN O
, PUNCT O
the DET O
BDNF PROPN B-AC
- PUNCT O
induced VERB O
recruitment NOUN O
of ADP O
PSD-95 PROPN B-AC
, PUNCT O
as ADP O
well ADV O
as ADP O
PLCγ NOUN O
and CCONJ O
Grb2 PROPN B-LF
- PUNCT I-LF
associated VERB I-LF
binder NOUN I-LF
1 NUM I-LF
( PUNCT O
Gab1 PROPN B-AC
) PUNCT O
with ADP O
TrkB PROPN O
receptors NOUN O
was AUX O
attenuated VERB O
, PUNCT O
resulting VERB O
in ADP O
reduced VERB O
activation NOUN O
of ADP O
PLCγ NOUN O
- PUNCT O
α NOUN B-LF
- PUNCT I-LF
calcium NOUN I-LF
/ SYM I-LF
calmodulin NOUN I-LF
- PUNCT I-LF
dependent ADJ I-LF
protein NOUN I-LF
kinase NOUN I-LF
II PROPN I-LF
( PUNCT O
CaMKII PROPN B-AC
) PUNCT O
and CCONJ O
PI3K PROPN O
- PUNCT O
Akt PROPN O
, PUNCT O
but CCONJ O
leaving VERB O
the DET O
extracellular ADJ O
signal NOUN O
- PUNCT O
regulated VERB O
kinase NOUN O
( PUNCT O
Erk PROPN O
) PUNCT O
pathway NOUN O
intact ADJ O
. PUNCT O

AHR NOUN B-AC
: PUNCT O
Adjusted VERB B-LF
Hazard NOUN I-LF
Ratio NOUN I-LF
; PUNCT O
ART NOUN B-AC
: PUNCT O
Antiretroviral ADJ B-LF
Therapy PROPN I-LF
; PUNCT O
CHR NOUN B-AC
: PUNCT O
Crude ADJ B-LF
Hazard NOUN I-LF
Ratio NOUN I-LF
; PUNCT O
CI NOUN O
: PUNCT O
Confidence NOUN O
Interval NOUN O
; PUNCT O
CPT NOUN B-AC
: PUNCT O
Cotrimoxazole PROPN O
Preventive PROPN O
Therapy PROPN O
; PUNCT O
IPT PROPN B-AC
: PUNCT O
Isoniazid PROPN O
Prophylactic PROPN O
Therapy PROPN O
; PUNCT O
TB NOUN O
: PUNCT O
Tuberculosis NOUN O

Bladder NOUN O
pain NOUN O
commonly ADV O
occurs VERB O
without ADP O
obvious ADJ O
bladder NOUN O
pathology NOUN O
and CCONJ O
is AUX O
a DET O
cardinal ADJ O
symptom NOUN O
of ADP O
interstitial ADJ B-LF
cystitis NOUN I-LF
/ SYM I-LF
painful ADJ I-LF
bladder NOUN I-LF
syndrome NOUN I-LF
( PUNCT O
IC PROPN B-AC
/ SYM B-AC
PBS PROPN B-AC
) PUNCT O
, PUNCT O
a DET O
chronic ADJ O
condition NOUN O
with ADP O
unknown ADJ O
etiology NOUN O
affecting VERB O
2.7–6.5 NUM O
% NOUN O
of ADP O
women NOUN O
in ADP O
the DET O
U.S. PROPN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
NNRTI PROPN B-AC
, PUNCT O
non ADJ B-LF
- ADJ I-LF
nucleoside NOUN I-LF
reverse ADJ I-LF
transcriptase NOUN I-LF
inhibitor NOUN I-LF
; PUNCT O
NRTI PROPN B-AC
, PUNCT O
nucleoside NOUN B-LF
reverse ADJ I-LF
transcriptase NOUN I-LF
inhibitor NOUN I-LF
; PUNCT O
VL PROPN B-AC
, PUNCT O
viral ADJ B-LF
load NOUN I-LF
. PUNCT O

CHW PROPN B-AC
, PUNCT O
community NOUN B-LF
health NOUN I-LF
worker NOUN I-LF
; PUNCT O
HF PROPN B-AC
, PUNCT O
health NOUN B-LF
facility NOUN I-LF
; PUNCT O
RRS PROPN B-AC
, PUNCT O
rapid ADJ B-LF
reporting NOUN I-LF
system NOUN I-LF
. PUNCT O

Phosphorylated VERB O
LuxO PROPN O
activates VERB O
the DET O
transcription NOUN O
of ADP O
the DET O
genes NOUN O
encoding VERB O
the DET O
small ADJ B-LF
RNAs NOUN I-LF
( PUNCT O
sRNAs NOUN B-AC
) PUNCT O
Qrr1 PROPN O
- ADV O
4 NUM O
, PUNCT O
which PRON O
in ADP O
turn NOUN O
post ADV O
- ADV O
transcriptionally ADV O
activate VERB O
AphA PROPN O
and CCONJ O
repress VERB O
HapR. PROPN O

KO PROPN B-AC
, PUNCT O
knockout NOUN B-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild NOUN B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

A DET O
more ADV O
neurophysiologically ADV O
grounded ADJ O
interpretation NOUN O
of ADP O
the DET O
MMN PROPN B-AC
, PUNCT O
known VERB O
as ADP O
the DET O
adaptation NOUN O
hypothesis NOUN O
, PUNCT O
denies VERB O
the DET O
existence NOUN O
of ADP O
a DET O
genuine ADJ O
process NOUN O
of ADP O
deviance NOUN O
detection NOUN O
, PUNCT O
arguing VERB O
that SCONJ O
the DET O
STD PROPN B-AC
induces VERB O
stimulus NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
adaptation NOUN I-LF
( PUNCT O
SSA PROPN B-AC
) PUNCT O
on ADP O
AC PROPN B-AC
neurons NOUN O
[ X O
15,16 NUM O
] PUNCT O
, PUNCT O
whose DET O
frequency NOUN O
channels NOUN O
simply ADV O
remain VERB O
fresh ADJ O
to ADP O
keep VERB O
responding VERB O
to ADP O
the DET O
DEV PROPN B-AC
[ X O
17,18 NUM O
] PUNCT O
. PUNCT O

The DET O
North PROPN B-LF
American PROPN I-LF
Consortium PROPN I-LF
for ADP I-LF
the DET I-LF
Study PROPN I-LF
of ADP I-LF
End PROPN I-LF
- PUNCT I-LF
stage NOUN I-LF
Liver PROPN I-LF
Disease PROPN I-LF
- PUNCT I-LF
Acute PROPN I-LF
on ADP I-LF
Chronic PROPN I-LF
Liver PROPN I-LF
Failure PROPN I-LF
( PUNCT O
NACSELD PROPN B-AC
- PUNCT B-AC
ACLF PROPN B-AC
) PUNCT O
definition NOUN O
was AUX O
used VERB O
to PART O
categorize VERB O
patients NOUN O
with ADP O
acute ADJ O
on ADP O
chronic ADJ O
liver NOUN O
failure NOUN O
on ADP O
the DET O
first ADJ O
day NOUN O
of ADP O
hospitalization NOUN O
[ PUNCT O
12 NUM O
] PUNCT O
. PUNCT O

We PRON O
conducted VERB O
health NOUN O
facility NOUN O
assessments NOUN O
between ADP O
July PROPN O
2015 NUM O
- PUNCT O
April PROPN O
2016 NUM O
, PUNCT O
with ADP O
retrospective ADJ O
review NOUN O
of ADP O
admission NOUN O
events NOUN O
between ADP O
1st NOUN O
July PROPN O
2014 NUM O
and CCONJ O
30th NOUN O
June PROPN O
2015 NUM O
, PUNCT O
and CCONJ O
used VERB O
estimates NOUN O
of ADP O
population NOUN O
- PUNCT O
based VERB O
incidence NOUN O
of ADP O
neonatal ADJ O
conditions NOUN O
in ADP O
Nairobi PROPN O
to PART O
explore VERB O
access NOUN O
and CCONJ O
evaluate VERB O
readiness NOUN O
of ADP O
public ADJ O
, PUNCT O
private ADJ B-LF
not PART I-LF
- PUNCT I-LF
for ADP I-LF
- PUNCT I-LF
profit NOUN I-LF
( PUNCT O
mission NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
private ADJ B-LF
- PUNCT I-LF
for ADP I-LF
- PUNCT I-LF
profit NOUN I-LF
( PUNCT O
private ADJ B-AC
) PUNCT O
sector NOUN O
facilities NOUN O
providing VERB O
24/7 NUM B-AC
inpatient ADJ O
neonatal ADJ O
care NOUN O
in ADP O
Nairobi PROPN O
City PROPN O
County PROPN O
. PUNCT O

BIC PROPN B-AC
, PUNCT O
Bayesian PROPN B-LF
Information PROPN I-LF
Criterion PROPN I-LF
, PUNCT O
ME PROPN B-AC
, PUNCT O
master NOUN B-LF
equation NOUN I-LF
. PUNCT O

DMSO PROPN O
, PUNCT O
dimethyl NOUN O
sulfoxide NOUN O
; PUNCT O
NPM1 PROPN B-AC
, PUNCT O
Nucleophosmin NOUN B-LF
1 NUM I-LF
; PUNCT O
p53 NOUN B-AC
: PUNCT O
protein NOUN B-LF
53 NUM I-LF
; PUNCT O
siRNA NOUN B-AC
, PUNCT O
small ADJ B-LF
interfering VERB I-LF
RNA NOUN I-LF
; PUNCT O
S34F PROPN B-AC
, PUNCT O
serine-34 NOUN B-LF
to ADP I-LF
phenylalanine NOUN I-LF
substitution NOUN I-LF
; PUNCT O
WST-1 PROPN B-AC
, PUNCT O
water NOUN B-LF
- PUNCT I-LF
soluble ADJ I-LF
tetrazolium-1 NOUN I-LF
; PUNCT O
wt NOUN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

X NOUN B-LF
- PUNCT I-LF
ray NOUN I-LF
absorption NOUN I-LF
spectroscopy NOUN I-LF
( PUNCT O
XAS NOUN B-AC
) PUNCT O
facilitates VERB O
monitoring NOUN O
of ADP O
redox NOUN O
and CCONJ O
geometry NOUN O
changes NOUN O
, PUNCT O
as ADP O
well ADV O
as ADP O
determination NOUN O
of ADP O
precise ADJ O
interatomic ADJ O
distances NOUN O
at ADP O
protein NOUN O
- PUNCT O
bound VERB O
metal NOUN O
centers NOUN O
[ PUNCT O
27 NUM O
, PUNCT O
28 NUM O
] PUNCT O
. PUNCT O

Bayley PROPN B-AC
- PUNCT B-AC
III PROPN B-AC
, PUNCT O
Bayley PROPN B-LF
Scales PROPN I-LF
of ADP I-LF
Infant PROPN I-LF
and CCONJ I-LF
Toddler PROPN I-LF
Development PROPN I-LF
– PUNCT I-LF
Third PROPN I-LF
Edition PROPN I-LF
; PUNCT O
CBQ PROPN B-AC
, PUNCT O
Children NOUN B-LF
’s PART I-LF
Behavior NOUN I-LF
Questionnaire NOUN I-LF
; PUNCT O
SDQ PROPN B-AC
, PUNCT O
Strengths NOUN B-LF
and CCONJ I-LF
Difficulties PROPN I-LF
Questionnaire NOUN I-LF
. PUNCT O

AC PROPN B-AC
, PUNCT O
auditory ADJ B-LF
cortex NOUN I-LF
; PUNCT O
BF NOUN B-AC
, PUNCT O
best ADJ B-LF
frequency NOUN I-LF
; PUNCT O
CF NOUN B-AC
, PUNCT O
characteristic ADJ B-LF
frequency NOUN I-LF
; PUNCT O
PSTH NOUN B-AC
, PUNCT O
peri NOUN B-LF
- PUNCT I-LF
stimulus NOUN I-LF
time NOUN I-LF
histogram NOUN I-LF
. PUNCT O

AAV PROPN B-AC
, PUNCT O
adeno NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
virus NOUN I-LF
; PUNCT O
CNO PROPN B-AC
, PUNCT O
clozapine NOUN B-LF
- PUNCT I-LF
n CCONJ I-LF
- PUNCT I-LF
oxide NOUN I-LF
; PUNCT O
hSyn PROPN O
, PUNCT O
human ADJ O
Synapsin-1 PROPN O
; PUNCT O
i.p NOUN B-AC
. PUNCT O
, PUNCT O
intraperitoneal ADJ B-LF
; PUNCT O
L PROPN O
- PUNCT O
ITR PROPN O
, PUNCT O
left ADJ O
inverted ADJ O
terminal ADJ O
repeat NOUN O
; PUNCT O
LH PROPN B-AC
, PUNCT O
lateral ADJ B-LF
hypothalamic ADJ I-LF
area NOUN I-LF
; PUNCT O
LMA PROPN B-AC
, PUNCT O
locomotor ADJ B-LF
activity NOUN I-LF
; PUNCT O
NREM PROPN B-AC
, PUNCT O
non ADJ B-LF
- PUNCT I-LF
rapid ADJ I-LF
eye NOUN I-LF
movement NOUN I-LF
; PUNCT O
Nts PROPN B-AC
, PUNCT O
neurotensin NOUN B-LF
; PUNCT O
R PROPN O
- PUNCT O
ITR PROPN O
, PUNCT O
right ADJ O
inverted ADJ O
terminal ADJ O
repeat NOUN O
; PUNCT O
REM PROPN B-AC
, PUNCT O
rapid ADJ B-LF
eye NOUN I-LF
movement NOUN I-LF
; PUNCT O
RM PROPN O
, PUNCT O
repeated VERB O
measures NOUN O
; PUNCT O
SA PROPN O
, PUNCT O
saline NOUN O
; PUNCT O
Tb PROPN B-AC
, PUNCT O
body NOUN B-LF
temperature NOUN I-LF
; PUNCT O
WPRE PROPN B-AC
, PUNCT O
woodchuck NOUN B-LF
hepatitis NOUN I-LF
virus NOUN I-LF
posttranscriptional ADJ I-LF
control NOUN I-LF
element NOUN I-LF
. PUNCT O

We PRON O
examined VERB O
GAPDH PROPN B-AC
properties NOUN O
in ADP O
acute ADJ O
mouse NOUN O
liver NOUN O
injury NOUN O
due ADP O
to ADP O
ethanol NOUN O
and/or CCONJ O
acetaminophen NOUN B-LF
( PUNCT O
APAP PROPN B-AC
) PUNCT O
treatment NOUN O
. PUNCT O

This DET O
property NOUN O
allows VERB O
MIS416 PROPN O
to ADP O
be AUX O
exploited VERB O
as ADP O
a DET O
vehicle NOUN O
for ADP O
the DET O
delivery NOUN O
of ADP O
peptide NOUN O
antigens NOUN O
or CCONJ O
other ADJ O
molecules NOUN O
( PUNCT O
for ADP O
example NOUN O
, PUNCT O
nucleic ADJ O
acids NOUN O
) PUNCT O
to ADP O
DCs PROPN B-AC
. PUNCT O
We PRON O
previously ADV O
showed VERB O
that SCONJ O
covalent ADJ O
( PUNCT O
non ADJ O
- ADJ O
cleavable ADJ O
) PUNCT O
conjugation NOUN O
of ADP O
OVA PROPN B-AC
, PUNCT O
a DET O
model NOUN O
antigen NOUN O
derived VERB O
from ADP O
ovalbumin NOUN B-LF
, PUNCT O
to ADP O
MIS416 PROPN O
enhanced VERB O
immune ADJ O
responses NOUN O
in ADP O
DCs PROPN B-AC
in ADP O
vivo ADJ O
, PUNCT O
compared VERB O
to ADP O
unconjugated ADJ O
MIS416 PROPN O
and CCONJ O
OVA PROPN B-AC
. PUNCT O
Intracellular ADJ O
trafficking NOUN O
promotes VERB O
the DET O
lysosomal ADJ O
degradation NOUN O
of ADP O
MIS416 PROPN O
, PUNCT O
leading VERB O
to ADP O
the DET O
destruction NOUN O
of ADP O
MIS416 PROPN O
plus CCONJ O
the DET O
associated VERB O
cargos NOUN O
conjugated VERB O
to ADP O
MIS416 PROPN O
. PUNCT O

The DET O
results NOUN O
revealed VERB O
that SCONJ O
PFKP PROPN B-AC
protein NOUN O
levels NOUN O
were AUX O
positively ADV O
related ADJ O
to ADP O
American PROPN B-LF
Joint PROPN I-LF
Committee PROPN I-LF
on ADP I-LF
Cancer PROPN I-LF
( PUNCT O
AJCC PROPN B-AC
) PUNCT O
stage NOUN O
( PUNCT O
P NOUN O
= SYM O
0.042 NUM O
, PUNCT O
Table NOUN O
1 NUM O
) PUNCT O
. PUNCT O

To PART O
determine VERB O
the DET O
thermal ADJ O
stability NOUN O
of ADP O
M10.5 NUM O
, PUNCT O
we PRON O
monitored VERB O
heat NOUN O
- PUNCT O
induced VERB O
unfolding NOUN O
by ADP O
recording VERB O
the DET O
circular ADJ B-LF
dichroism NOUN I-LF
( PUNCT O
CD NOUN B-AC
) PUNCT O
signal NOUN O
at ADP O
223 NUM O
nm NOUN O
as ADP O
a DET O
function NOUN O
of ADP O
increasing VERB O
temperature NOUN O
. PUNCT O

Mature ADJ O
gametocytes NOUN O
are AUX O
sexually ADV O
dimorphic ADJ O
, PUNCT O
forming VERB O
microgametocytes NOUN O
and CCONJ O
macrogametocytes NOUN O
that PRON O
escape VERB O
the DET O
red ADJ B-LF
blood NOUN I-LF
cell NOUN I-LF
( PUNCT O
RBC NOUN B-AC
) PUNCT O
and CCONJ O
produce VERB O
male ADJ O
and CCONJ O
female ADJ O
gametes NOUN O
in ADP O
the DET O
blood NOUN O
meal NOUN O
of ADP O
the DET O
mosquito NOUN O
by ADP O
processes NOUN O
known VERB O
as ADP O
exflagellation NOUN O
[ X O
8 NUM O
] X O
and CCONJ O
activation NOUN O
, PUNCT O
respectively ADV O
. PUNCT O

In ADP O
addition NOUN O
, PUNCT O
we PRON O
estimated VERB O
the DET O
likelihood NOUN B-LF
to ADP I-LF
be AUX I-LF
helped VERB I-LF
or CCONJ I-LF
harmed VERB I-LF
( PUNCT O
LHH PROPN B-AC
) PUNCT O
, PUNCT O
defined VERB O
as ADP O
the DET O
ratio NOUN O
of ADP O
the DET O
NNH NOUN B-AC
to ADP O
NNT NOUN B-AC
; PUNCT O
LLH PROPN O
values NOUN O
< ADP O
1 NUM O
indicated VERB O
that SCONJ O
the DET O
number NOUN O
of ADP O
incident NOUN O
cases NOUN O
of ADP O
T2D NOUN B-AC
incurred VERB O
exceeded VERB O
the DET O
number NOUN O
of ADP O
ASCVD PROPN B-AC
events NOUN O
prevented VERB O
[ PUNCT O
38 NUM O
] PUNCT O
. PUNCT O

BMI PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
HKDB PROPN B-AC
, PUNCT O
Hong PROPN B-LF
Kong PROPN I-LF
Diabetes PROPN I-LF
Biobank PROPN I-LF
; PUNCT O
PRS PROPN B-AC
, PUNCT O
polygenic ADJ B-LF
risk NOUN I-LF
score NOUN I-LF
. PUNCT O

To ADP O
date NOUN O
, PUNCT O
several ADJ O
candidates NOUN O
have AUX O
been AUX O
proposed VERB O
to PART O
act VERB O
as ADP O
self NOUN O
- X O
Ags NOUN B-AC
for ADP O
iNKT PROPN B-AC
cells NOUN O
, PUNCT O
including VERB O
β NOUN O
- X O
linked ADJ O
glycosphingolipids NOUN B-LF
( PUNCT O
GSLs PROPN B-AC
) PUNCT O
( PUNCT O
isoglobotrihexosylceramide NOUN B-LF
[ PUNCT O
iGb3 X B-AC
] PUNCT O
[ PUNCT O
4,5 NUM O
] PUNCT O
, PUNCT O
gangliosides NOUN O
[ PUNCT O
6,7 NUM O
] PUNCT O
and CCONJ O
β NOUN B-LF
- X I-LF
glucosylceramide NOUN I-LF
[ PUNCT O
β NOUN B-AC
- X B-AC
GlcCer X B-AC
] PUNCT O
[ PUNCT O
8 NUM O
] PUNCT O
) PUNCT O
, PUNCT O
and CCONJ O
phospholipids NOUN O
[ PUNCT O
9 NUM O
] PUNCT O
. PUNCT O

Additionally ADV O
, PUNCT O
dried VERB B-LF
blood NOUN I-LF
spots NOUN I-LF
( PUNCT O
DBS NOUN B-AC
) PUNCT O
were AUX O
collected VERB O
and CCONJ O
stored VERB O
for ADP O
molecular ADJ O
testing NOUN O
of ADP O
parasites NOUN O
. PUNCT O

Volunteers NOUN O
transcribe VERB O
patient NOUN O
demographic ADJ O
, PUNCT O
diagnostic ADJ O
, PUNCT O
and CCONJ O
treatment NOUN O
data NOUN O
into ADP O
the DET O
patient NOUN B-LF
information NOUN I-LF
system NOUN I-LF
( PUNCT O
PIS PROPN B-AC
) PUNCT O
software NOUN O
( PUNCT O
custom ADV O
- PUNCT O
built VERB O
by ADP O
Orbis PROPN O
Bangladesh PROPN O
, PUNCT O
Dhaka PROPN O
, PUNCT O
Bangladesh PROPN O
) PUNCT O
. PUNCT O

DR NOUN B-AC
- PUNCT B-AC
TB NOUN B-AC
, PUNCT O
drug NOUN B-LF
- PUNCT I-LF
resistant ADJ I-LF
tuberculosis NOUN I-LF
; PUNCT O
TB NOUN B-AC
, PUNCT O
tuberculosis NOUN B-LF
. PUNCT O

Please INTJ O
add VERB O
the DET O
following ADJ O
statement NOUN O
, PUNCT O
or CCONJ O
similar ADJ O
, PUNCT O
to ADP O
the DET O
Methods NOUN O
: PUNCT O
" PUNCT O
This DET O
study NOUN O
is AUX O
reported VERB O
as ADP O
per ADP O
the DET O
Strengthening VERB B-LF
the DET I-LF
Reporting PROPN I-LF
of ADP I-LF
Observational PROPN I-LF
Studies PROPN I-LF
in ADP I-LF
Epidemiology PROPN I-LF
( PUNCT O
STROBE PROPN B-AC
) PUNCT O
guideline NOUN O
( PUNCT O
S1 PROPN O
Checklist PROPN O
) PUNCT O
. PUNCT O
" PUNCT O

Accordingly ADV O
, PUNCT O
this DET O
research NOUN O
proposes VERB O
a DET O
Memetic PROPN O
Differential PROPN B-LF
Evolution PROPN I-LF
algorithm NOUN I-LF
( PUNCT O
MDETC PROPN B-AC
) PUNCT O
to PART O
solve VERB O
the DET O
text NOUN O
clustering NOUN O
problem NOUN O
, PUNCT O
which PRON O
aims VERB O
to PART O
address VERB O
the DET O
effect NOUN O
of ADP O
the DET O
hybridization NOUN O
between ADP O
the DET O
differential ADJ O
evolution NOUN O
( PUNCT O
DE PROPN B-AC
) PUNCT O
mutation NOUN O
strategy NOUN O
with ADP O
the DET O
memetic ADJ B-LF
algorithm NOUN I-LF
( PUNCT O
MA NOUN B-AC
) PUNCT O
. PUNCT O
This DET O
hybridization NOUN O
intends VERB O
to PART O
enhance VERB O
the DET O
quality NOUN O
of ADP O
text NOUN O
clustering NOUN O
and CCONJ O
improve VERB O
the DET O
exploitation NOUN O
and CCONJ O
exploration NOUN O
capabilities NOUN O
of ADP O
the DET O
algorithm NOUN O
. PUNCT O

AUC PROPN B-AC
is AUX O
the DET O
area NOUN B-LF
under ADP I-LF
the DET I-LF
receiver NOUN I-LF
operating NOUN I-LF
characteristic NOUN I-LF
curve NOUN I-LF
, PUNCT O
COR PROPN O
is AUX O
point NOUN O
biserial ADJ O
correlation NOUN O
coefficient NOUN O
, PUNCT O
AIC PROPN O
is AUX O
the DET O
Akaike PROPN O
information NOUN O
criterion NOUN O
, PUNCT O
and CCONJ O
BIC PROPN O
is AUX O
the DET O
Bayesian ADJ O
information NOUN O
criterion NOUN O
. PUNCT O

Minimal ADJ B-LF
medium NOUN I-LF
( PUNCT O
MM NOUN B-AC
) PUNCT O
was AUX O
formulated VERB O
as SCONJ O
previously ADV O
described VERB O
[ X O
8 NUM O
] PUNCT O
. PUNCT O

AL PROPN O
, PUNCT O
artemether NOUN O
– SYM O
lumefantrine NOUN O
fixed ADJ O
- PUNCT O
dose NOUN O
combination NOUN O
; PUNCT O
AQ PROPN O
+ SYM O
AS PROPN O
, PUNCT O
artesunate NOUN O
+ SYM O
amodiaquine NOUN O
non ADJ O
- PUNCT O
fixed ADJ O
dose NOUN O
combination NOUN O
; PUNCT O
ASAQ PROPN B-AC
, PUNCT O
artesunate NOUN B-LF
– SYM I-LF
amodiaquine NOUN I-LF
fixed ADJ O
- PUNCT O
dose NOUN O
combination NOUN O
; PUNCT O
CQ PROPN O
, PUNCT O
chloroquine NOUN O
; PUNCT O
DP PROPN O
, PUNCT O
dihydroartemisinin NOUN O
– SYM O
piperaquine NOUN O
fixed ADJ O
- PUNCT O
dose NOUN O
combination NOUN O
; PUNCT O
ECG PROPN O
, PUNCT O
electrocardiogram NOUN O
; PUNCT O
PA PROPN O
, PUNCT O
pyronaridine NOUN O
– SYM O
artesunate NOUN O
fixed ADJ O
- PUNCT O
dose NOUN O
combination NOUN O
; PUNCT O
PK PROPN O
, PUNCT O
pharmacokinetic ADJ O
; PUNCT O
TdP PROPN B-AC
, PUNCT O
torsades X B-LF
de X I-LF
pointes X I-LF
; PUNCT O
WANECAM PROPN B-AC
, PUNCT O
West PROPN B-LF
African PROPN I-LF
Network PROPN I-LF
for ADP I-LF
Clinical PROPN I-LF
Trials PROPN I-LF
of ADP I-LF
Antimalarial PROPN I-LF
Drugs PROPN I-LF
. PUNCT O

Diamond NOUN O
denotes VERB O
the DET O
pooled VERB O
odds NOUN B-LF
ratio NOUN I-LF
( PUNCT O
OR NOUN B-AC
) PUNCT O
indicating VERB O
reduced VERB O
risk NOUN O
( PUNCT O
OR NOUN B-AC
0.37 NUM O
) PUNCT O
. PUNCT O

We PRON O
conducted VERB O
a DET O
prospective ADJ O
, PUNCT O
single ADJ O
- PUNCT O
center NOUN O
, PUNCT O
cohort NOUN O
study NOUN O
in ADP O
the DET O
Liver PROPN O
Transplant PROPN O
Unit PROPN O
at ADP O
King PROPN B-LF
Faisal PROPN I-LF
Specialist PROPN I-LF
Hospital PROPN I-LF
and CCONJ I-LF
Research PROPN I-LF
Centre PROPN I-LF
( PUNCT O
KFSH&RC PROPN B-AC
) PUNCT O
from ADP O
April PROPN O
2016 NUM O
to ADP O
February PROPN O
2020 NUM O
. PUNCT O

Body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT O
BMI PROPN B-AC
) PUNCT O
was AUX O
calculated VERB O
as ADP O
weight NOUN O
( PUNCT O
kg)/height NOUN O
( PUNCT O
m NOUN O
) PUNCT O
squared VERB O
. PUNCT O

ANC PROPN B-AC
: PUNCT O
Antenatal ADJ B-LF
care NOUN I-LF
. PUNCT O

Serum ADJ B-LF
amyloid NOUN I-LF
A PROPN I-LF
( PUNCT O
SAA PROPN B-AC
) PUNCT O
phosphorylated VERB O
at ADP O
serine NOUN O
166 NUM O
( PUNCT O
pS166 NOUN O
) PUNCT O
, PUNCT O
kininogen NOUN O
1 NUM O
phosphorylated VERB O
at ADP O
threonine NOUN O
326 NUM O
( PUNCT O
pT326 NOUN O
) PUNCT O
, PUNCT O
Fibrinogen NOUN O
α NOUN O
phosphorylated VERB O
at ADP O
threonine NOUN O
20 NUM O
( PUNCT O
pT20 NOUN O
) PUNCT O
and CCONJ O
at ADP O
serine NOUN O
22 NUM O
( PUNCT O
pS22 NOUN O
) PUNCT O
are AUX O
shown VERB O
for ADP O
samples NOUN O
from ADP O
controls NOUN O
( PUNCT O
C NOUN O
) PUNCT O
and CCONJ O
samples NOUN O
from ADP O
dogs NOUN O
suffering VERB O
from ADP O
babesiosis NOUN O
( PUNCT O
B NOUN O
) PUNCT O
. PUNCT O
p NOUN O
- PUNCT O
value NOUN O
for ADP O
the DET O
comparison NOUN O
C NOUN O
vs. ADP O

Previously ADV O
, PUNCT O
it PRON O
was AUX O
shown VERB O
that SCONJ O
endothelial ADJ B-LF
progenitor NOUN I-LF
cells NOUN I-LF
( PUNCT O
EPCs NOUN B-AC
) PUNCT O
are AUX O
increased VERB O
during ADP O
human ADJ O
pregnancy NOUN O
[ X O
72 NUM O
] PUNCT O
and CCONJ O
that SCONJ O
EPCs NOUN B-AC
directly ADV O
contribute VERB O
to ADP O
ECs NOUN B-AC
within ADP O
decidual ADJ O
vasculature NOUN O
by ADP O
vasculogenesis NOUN O
in ADP O
mouse NOUN O
pregnancy NOUN O
[ X O
73 NUM O
] PUNCT O
. PUNCT O

Our PRON O
group NOUN O
has AUX O
therefore ADV O
utilized VERB O
a DET O
glycosylation NOUN B-LF
independent ADJ I-LF
lysosomal NOUN I-LF
targeting NOUN I-LF
( PUNCT O
GILT PROPN B-AC
) PUNCT O
system NOUN O
, PUNCT O
whereby SCONJ O
IGF2 PROPN B-AC
has AUX O
been AUX O
fused VERB O
to ADP O
rhNAGLU NOUN B-AC
( PUNCT O
rhNAGLU NOUN B-AC
- PUNCT O
IGF2 PROPN B-AC
; PUNCT O
BMN PROPN O
250 NUM O
) PUNCT O
to ADP O
mediate VERB O
CI NOUN B-AC
- PUNCT B-AC
MPR NOUN B-AC
- PUNCT O
mediated VERB O
cellular ADJ O
uptake NOUN O
and CCONJ O
delivery NOUN O
to ADP O
lysosomes NOUN O
[ X O
18–20 NUM O
] PUNCT O
. PUNCT O

Logistic ADJ O
regression NOUN O
analyses NOUN O
were AUX O
used VERB O
to PART O
determine VERB O
whether SCONJ O
MS PROPN B-AC
and/or CCONJ O
its PRON O
various ADJ O
components NOUN O
were AUX O
significant ADJ O
factors NOUN O
associated VERB O
with ADP O
the DET O
presence NOUN O
of ADP O
SDB PROPN B-AC
. PUNCT O
Continuous ADJ O
data NOUN O
were AUX O
expressed VERB O
as ADP O
the DET O
mean NOUN O
± SYM O
standard ADJ B-LF
deviation NOUN I-LF
( PUNCT O
SD NOUN B-AC
) PUNCT O
and CCONJ O
compared VERB O
by ADP O
Student PROPN O
t NOUN O
test NOUN O
or CCONJ O
non ADJ O
- ADJ O
parametric ADJ O
test NOUN O
, PUNCT O
when SCONJ O
appropriate ADJ O
. PUNCT O

The DET O
sporozoites NOUN O
travel VERB O
to ADP O
the DET O
liver NOUN O
and CCONJ O
develop VERB O
in ADP O
hepatocytes NOUN O
to ADP O
large ADJ O
exoerythrocytic ADJ B-LF
forms NOUN I-LF
( PUNCT O
EEFs NOUN B-AC
) PUNCT O
[ X O
5,6 NUM O
] PUNCT O
. PUNCT O

Objective NOUN O
of ADP O
this DET O
study NOUN O
was AUX O
to PART O
evaluate VERB O
the DET O
effectiveness NOUN O
of ADP O
the DET O
iterative ADJ B-LF
reconstruction NOUN I-LF
of ADP I-LF
high ADJ I-LF
- PUNCT I-LF
pitch NOUN I-LF
dual ADJ I-LF
- PUNCT I-LF
source NOUN I-LF
chest NOUN I-LF
CT NOUN I-LF
( PUNCT O
IR NOUN B-AC
- PUNCT B-AC
HP NOUN B-AC
- PUNCT B-AC
CT NOUN B-AC
) PUNCT O
scanned VERB O
with ADP O
low ADJ O
radiation NOUN O
exposure NOUN O
compared VERB O
with ADP O
low ADJ O
dose NOUN O
chest NOUN O
CT NOUN O
( PUNCT O
LDCT PROPN B-AC
) PUNCT O
. PUNCT O

The DET O
differentially ADV B-LF
methylated VERB I-LF
regions NOUN I-LF
( PUNCT O
DMRs NOUN B-AC
) PUNCT O
that PRON O
were AUX O
located VERB O
in ADP O
promoter NOUN O
regions NOUN O
and CCONJ O
completely ADV O
overlapped VERB O
with ADP O
CpG NOUN B-LF
islands NOUN I-LF
( PUNCT O
CGI PROPN B-AC
) PUNCT O
were AUX O
identified VERB O
as ADP O
candidate NOUN O
DMRs NOUN B-AC
. PUNCT O
Gene NOUN B-LF
ontology NOUN I-LF
( PUNCT O
GO PROPN B-AC
) PUNCT O
analysis NOUN O
and CCONJ O
Pathway PROPN O
analysis NOUN O
were AUX O
performed VERB O
to PART O
determine VERB O
the DET O
roles NOUN O
of ADP O
the DET O
candidate NOUN O
DMRs NOUN B-AC
’ PART O
corresponding VERB O
genes NOUN O
in ADP O
biological ADJ O
pathways NOUN O
or CCONJ O
identify VERB O
GO PROPN B-AC
terms NOUN O
using VERB O
MAS PROPN O
3.0 NUM O
( PUNCT O
http://bioinfo.capitalbio.com/mas3/ X O
) PUNCT O
. PUNCT O

LN PROPN B-AC
, PUNCT O
linear ADJ B-LF
– PUNCT I-LF
nonlinear ADJ I-LF
; PUNCT O
STRF PROPN B-AC
, PUNCT O
spectrotemporal ADJ B-LF
receptive ADJ I-LF
field NOUN I-LF
. PUNCT O

MDA PROPN B-AC
is AUX O
unstable ADJ O
and CCONJ O
can AUX O
further ADV O
react VERB O
with ADP O
acetaldehyde NOUN O
to PART O
form VERB O
malondialdehyde NOUN B-LF
acetaldehyde NOUN I-LF
- PUNCT O
modified VERB O
LDL PROPN B-AC
( PUNCT O
MAA PROPN B-AC
- PUNCT O
LDL PROPN B-AC
) PUNCT O
[ PUNCT O
4–6 NUM O
] PUNCT O
. PUNCT O

At ADP O
12 NUM O
weeks NOUN O
of ADP O
infant NOUN O
age NOUN O
, PUNCT O
mean ADJ O
anti ADJ O
- ADJ O
diphtheria ADJ O
titres NOUN O
were AUX O
significantly ADV O
higher ADJ O
in ADP O
infants NOUN O
born VERB O
to ADP O
mothers NOUN O
who PRON O
received VERB O
MMN PROPN B-AC
( PUNCT O
0.16 NUM O
IU NOUN O
/ SYM O
mL NOUN O
, PUNCT O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
[ X O
CI NOUN B-AC
] X O
0.14–0.19 NUM O
) PUNCT O
or CCONJ O
PE PROPN B-AC
+ SYM O
MMN PROPN B-AC
( PUNCT O
0.14 NUM O
IU NOUN O
/ SYM O
mL NOUN O
, PUNCT O
0.12–0.16 NUM O
) PUNCT O
during ADP O
pregnancy NOUN O
compared VERB O
with ADP O
FeFol PROPN B-AC
( PUNCT O
0.10 NUM O
IU NOUN O
/ SYM O
mL NOUN O
, PUNCT O
0.09–0.12 NUM O
) PUNCT O
. PUNCT O

The DET O
most ADV O
common ADJ O
diagnoses NOUN O
were AUX O
viral ADJ O
respiratory ADJ O
tract NOUN O
infection NOUN O
caused VERB O
by ADP O
RSV PROPN O
, PUNCT O
influenza NOUN O
B PROPN O
, PUNCT O
rhinovirus NOUN O
, PUNCT O
enterovirus NOUN O
and CCONJ O
influenza NOUN O
A PROPN O
, PUNCT O
whereas SCONJ O
the DET O
most ADV O
common ADJ O
bacterial ADJ O
infections NOUN O
were AUX O
Group PROPN B-LF
A PROPN I-LF
streptococci NOUN I-LF
( PUNCT O
GAS PROPN B-AC
) PUNCT O
, PUNCT O
CXR PROPN B-AC
- PUNCT O
confirmed VERB O
pneumonia NOUN O
and CCONJ O
Shigella PROPN O
gastroenteritis NOUN O
( PUNCT O
Fig NOUN O
6 NUM O
, PUNCT O
Fig NOUN O
7B NUM O
and CCONJ O
7C NUM O
) PUNCT O
. PUNCT O

For ADP O
example NOUN O
, PUNCT O
Lopez PROPN O
et PROPN O
al NOUN O
. PUNCT O
reported VERB O
that SCONJ O
GE PROPN O
deteriorates VERB O
as SCONJ O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT O
BMI PROPN B-AC
) PUNCT O
increases VERB O
in ADP O
nondiabetic ADJ O
individuals NOUN O
, PUNCT O
whereas SCONJ O
Healy PROPN O
et PROPN O
al NOUN O
. PUNCT O
reported VERB O
contrasting VERB O
findings NOUN O
[ PUNCT O
13 NUM O
, PUNCT O
14 NUM O
] PUNCT O
. PUNCT O

TY PROPN B-AC
, PUNCT O
time NOUN O
yield NOUN O
; PUNCT O
STY PROPN B-AC
, PUNCT O
space NOUN O
- PUNCT O
time NOUN O
yield NOUN O
; PUNCT O
VB PROPN B-AC
, PUNCT O
virus NOUN B-LF
bioreactor NOUN I-LF
. PUNCT O

The DET O
study NOUN O
was AUX O
approved VERB O
by ADP O
the DET O
scientific ADJ O
committee NOUN O
of ADP O
the DET O
Dutch ADJ B-LF
pathology NOUN I-LF
registry NOUN I-LF
( PUNCT O
PALGA PROPN B-AC
) PUNCT O
and CCONJ O
the DET O
Dutch ADJ O
perinatal ADJ O
registry NOUN O
( PUNCT O
Perined PROPN B-AC
) PUNCT O
. PUNCT O

ER NOUN B-AC
, PUNCT O
endoplasmic ADJ B-LF
reticulum NOUN I-LF
. PUNCT O

Mohammadi PROPN O
et PROPN O
al NOUN O
. PUNCT O
[ X O
68 NUM O
] X O
investigated VERB O
antibacterial ADJ O
efficacy NOUN O
on ADP O
Streptococcus PROPN B-LF
mutans NOUN I-LF
( PUNCT O
S. PROPN B-AC
mutans NOUN B-AC
) PUNCT O
and CCONJ O
S. PROPN B-AC
aureus NOUN B-AC
, PUNCT O
while SCONJ O
Morgental PROPN O
et PROPN O
al NOUN O
. PUNCT O
[ X O
16 NUM O
] X O
used VERB O
E. NOUN B-AC
faecalis NOUN B-AC
. PUNCT O

Beside ADP O
being AUX O
a DET O
risk NOUN O
factor NOUN O
for ADP O
end ADJ B-LF
- ADJ I-LF
stage NOUN I-LF
renal ADJ I-LF
disease NOUN I-LF
( PUNCT O
ESRD PROPN B-AC
) PUNCT O
, PUNCT O
CKD PROPN B-AC
is AUX O
an DET O
important ADJ O
cardiovascular ADJ B-LF
disease NOUN I-LF
( PUNCT O
CVD NOUN B-AC
) PUNCT O
risk NOUN O
factor NOUN O
, PUNCT O
and CCONJ O
most ADJ O
patients NOUN O
with ADP O
CKD PROPN B-AC
die VERB O
from ADP O
CVD NOUN B-AC
before SCONJ O
any DET O
renal ADJ O
replacement NOUN O
therapy NOUN O
is AUX O
initiated VERB O
[ X O
5 NUM O
] PUNCT O
. PUNCT O

Measurements NOUN O
were AUX O
conducted VERB O
at ADP O
12 NUM O
and CCONJ O
24 NUM O
days NOUN B-LF
after ADP I-LF
planting NOUN I-LF
( PUNCT O
DAP PROPN B-AC
) PUNCT O
. PUNCT O
Data NOUN O
presented VERB O
are AUX O
means NOUN O
± ADP O
standard ADJ O
error NOUN O
. PUNCT O

Screening NOUN O
mammograms NOUN O
are AUX O
interpreted VERB O
according VERB O
to ADP O
the DET O
Breast PROPN B-LF
Imaging PROPN I-LF
Reporting PROPN I-LF
and CCONJ I-LF
Data PROPN I-LF
System PROPN I-LF
( PUNCT O
BI PROPN B-AC
- PUNCT B-AC
RADS PROPN B-AC
) PUNCT O
scale NOUN O
by ADP O
trained VERB O
breast NOUN O
radiologists NOUN O
[ PUNCT O
19 NUM O
] PUNCT O
. PUNCT O

Data NOUN O
were AUX O
collected VERB O
from ADP O
GeneXpert PROPN O
software NOUN O
and CCONJ O
Laboratory PROPN B-LF
Information PROPN I-LF
System PROPN I-LF
( PUNCT O
LIS PROPN B-AC
) PUNCT O
databases NOUN O
. PUNCT O

The DET O
Danish PROPN B-LF
National PROPN I-LF
Birth PROPN I-LF
Cohort PROPN I-LF
( PUNCT O
DNBC PROPN B-AC
) PUNCT O
is AUX O
, PUNCT O
to PART O
our PRON O
knowledge NOUN O
, PUNCT O
one NUM O
of ADP O
the DET O
first ADJ O
large ADJ O
prospective ADJ O
studies NOUN O
to PART O
comprehensively ADV O
assess VERB O
dietary ADJ O
intake NOUN O
in ADP O
pregnancy NOUN O
and CCONJ O
again ADV O
during ADP O
the DET O
adolescent ADJ O
years NOUN O
. PUNCT O

Such ADJ O
resistance NOUN O
can AUX O
be AUX O
explained VERB O
by ADP O
the DET O
presence NOUN O
, PUNCT O
inside ADP O
the DET O
core NOUN O
, PUNCT O
of ADP O
α NOUN O
/ SYM O
β NOUN O
- PUNCT O
type NOUN O
small ADJ B-LF
, PUNCT I-LF
acid NOUN I-LF
- PUNCT I-LF
soluble ADJ I-LF
spore NOUN I-LF
proteins NOUN I-LF
( PUNCT O
SASPs PROPN B-AC
) PUNCT O
. PUNCT O

Confusion NOUN O
matrices NOUN O
of ADP O
deep ADJ O
transfer NOUN O
learning NOUN O
models NOUN O
and CCONJ O
ophthalmologists NOUN O
in ADP O
detecting VERB O
activated VERB O
dendritic ADJ B-LF
cells NOUN I-LF
( PUNCT O
DCs NOUN B-AC
) PUNCT O
and CCONJ O
inflammatory ADJ O
cells NOUN O
are AUX O
shown VERB O
. PUNCT O

In ADP O
order NOUN O
to ADP O
demonstrate VERB O
the DET O
involvement NOUN O
of ADP O
Nrf2 NOUN B-AC
in ADP O
the DET O
activation NOUN O
of ADP O
HO-1 NOUN B-AC
, PUNCT O
GCLM PROPN B-AC
and CCONJ O
x NOUN B-AC
- ADJ B-AC
CT NOUN B-AC
, PUNCT O
Nrf2 NOUN B-AC
activity NOUN O
in ADP O
BTZ PROPN B-AC
- ADJ O
treated VERB O
cells NOUN O
has AUX O
been AUX O
inhibited VERB O
by ADP O
all DET B-LF
- ADJ I-LF
trans ADJ I-LF
- ADJ I-LF
Retinoic ADJ I-LF
acid NOUN I-LF
( PUNCT O
ATRA PROPN B-AC
) PUNCT O
. PUNCT O
Indeed ADV O
, PUNCT O
retinoic ADJ O
acid NOUN O
receptors NOUN O
RARalpha PROPN O
and CCONJ O
RXR PROPN O
have AUX O
been AUX O
demonstrated VERB O
to ADP O
interfere VERB O
with ADP O
the DET O
binding NOUN O
of ADP O
Nrf2 NOUN B-AC
to ADP O
ARE NOUN B-AC
sequences NOUN O
, PUNCT O
decreasing VERB O
the DET O
transcription NOUN O
of ADP O
its PRON O
target NOUN O
genes NOUN O
[ PUNCT O
49 NUM O
, PUNCT O
67 NUM O
] PUNCT O
. PUNCT O

Tuberculosis NOUN B-LF
minisite NOUN O
from ADP O
the DET O
World PROPN O
Health PROPN O
Organization PROPN O
, PUNCT O
providing VERB O
data NOUN O
on ADP O
tuberculosis NOUN B-LF
worldwide ADV O
, PUNCT O
details NOUN O
of ADP O
the DET O
Stop VERB O
TB PROPN B-AC
strategy NOUN O
, PUNCT O
as ADP O
well ADV O
as ADP O
fact NOUN O
sheets NOUN O
and CCONJ O
current ADJ O
guidelines NOUN O

Previous ADJ O
investigations NOUN O
have AUX O
determined VERB O
the DET O
role NOUN O
of ADP O
several ADJ O
single ADJ B-LF
nucleotide NOUN I-LF
polymorphisms NOUN I-LF
( PUNCT O
SNPs NOUN B-AC
) PUNCT O
to PART O
explain VERB O
inter ADJ O
- ADJ O
individual ADJ O
variability NOUN O
of ADP O
serum ADJ O
creatine NOUN B-LF
kinase NOUN I-LF
( PUNCT O
CK PROPN B-AC
) PUNCT O
concentrations NOUN O
after ADP O
exertional ADJ O
muscle NOUN O
damage NOUN O
. PUNCT O

All DET O
predicted VERB O
gene NOUN O
- PUNCT O
order NOUN O
disruptions NOUN O
identified VERB O
using VERB O
this DET O
gene NOUN O
- PUNCT O
based VERB O
BLAST NOUN O
approach NOUN O
are AUX O
also ADV O
identified VERB O
as ADP O
termini NOUN O
of ADP O
whole ADJ O
- PUNCT O
genome NOUN O
global ADJ O
alignments NOUN O
at ADP O
the DET B-LF
University PROPN I-LF
of ADP I-LF
California PROPN I-LF
, PUNCT I-LF
Santa PROPN I-LF
Cruz PROPN I-LF
( PUNCT O
UCSC PROPN B-AC
) PUNCT O
[ PUNCT O
65 NUM O
] PUNCT O
. PUNCT O

Cul4b PROPN B-AC
, PUNCT O
Cullin-4b NOUN B-LF
; PUNCT O
TCR PROPN B-AC
, PUNCT O
T PROPN B-LF
cell NOUN I-LF
receptor NOUN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

We PRON O
compared VERB O
F75 PROPN B-AC
to ADP O
the DET O
modified VERB B-LF
F75 PROPN I-LF
( PUNCT O
mF75 NOUN B-AC
) PUNCT O
formulation NOUN O
( PUNCT O
Table PROPN O
1 NUM O
) PUNCT O
. PUNCT O

“ PUNCT O
Negative ADJ B-LF
Histopathology NOUN O
” PUNCT O
( PUNCT O
NEG)–absence NOUN B-AC
of ADP O
granulomatous ADJ O
changes NOUN O
resembling VERB O
OJD PROPN B-AC
and CCONJ O
no DET O
AFOs NOUN B-AC
detected VERB O
. PUNCT O

For ADP O
the DET O
underlying VERB O
data NOUN O
, PUNCT O
see VERB O
https://osf.io/VSZCB/. X O
EEG NOUN B-AC
, PUNCT O
electroencephalography NOUN B-LF
. PUNCT O

HR NOUN B-AC
, PUNCT O
highly ADV B-LF
reducing VERB I-LF
; PUNCT O
NR PROPN B-AC
, PUNCT O
nonreducing VERB B-LF
; PUNCT O
NRPS PROPN B-AC
, PUNCT O
nonribosomal ADJ B-LF
peptide NOUN I-LF
synthase NOUN I-LF
; PUNCT O
PKS PROPN B-AC
, PUNCT O
polyketide NOUN B-LF
synthase NOUN I-LF
; PUNCT O
SM PROPN B-AC
, PUNCT O
secondary ADJ B-LF
metabolite NOUN I-LF
. PUNCT O

The DET O
pulmonary ADJ O
collectins NOUN O
, PUNCT O
surfactant NOUN B-LF
proteins NOUN I-LF
A PROPN O
and CCONJ O
D PROPN O
( PUNCT O
SP PROPN B-AC
- PUNCT O
A PROPN O
and CCONJ O
SP PROPN B-AC
- PUNCT O
D PROPN O
) PUNCT O
have AUX O
been AUX O
implicated VERB O
in ADP O
the DET O
regulation NOUN O
of ADP O
the DET O
innate ADJ O
immune ADJ O
system NOUN O
within ADP O
the DET O
lung NOUN O
. PUNCT O

CI PROPN O
, PUNCT O
confidence NOUN O
interval NOUN O
; PUNCT O
RR PROPN B-AC
, PUNCT O
risk NOUN B-LF
ratio NOUN I-LF
. PUNCT O

Cytosolic ADJ O
β NOUN O
- PUNCT O
catenin NOUN O
protein NOUN O
becomes VERB O
stabilized ADJ O
and CCONJ O
newly ADV O
synthesized VERB O
β NOUN O
- PUNCT O
catenin NOUN O
is AUX O
able ADJ O
to ADP O
accumulate VERB O
and CCONJ O
then ADV O
translocate VERB O
to ADP O
the DET O
nucleus NOUN O
where SCONJ O
binding VERB O
to ADP O
T NOUN B-LF
- PUNCT I-LF
cell NOUN I-LF
factor NOUN I-LF
( PUNCT O
TCF)/lymphoid NOUN B-LF
enhancer NOUN I-LF
factor NOUN I-LF
( PUNCT O
LEF PROPN B-AC
) PUNCT O
transcription NOUN O
factors NOUN O
leads VERB O
to ADP O
the DET O
activation NOUN O
of ADP O
target NOUN O
gene NOUN O
expression NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

IPA PROPN B-AC
, PUNCT O
Ingenuity PROPN B-LF
Pathway PROPN I-LF
Analysis NOUN I-LF
. PUNCT O

Moreover ADV O
, PUNCT O
the DET O
release NOUN O
of ADP O
exosomes NOUN O
from ADP O
cells NOUN O
was AUX O
also ADV O
observed VERB O
following VERB O
ionomycin NOUN O
addition NOUN O
but CCONJ O
not PART O
with ADP O
granulocyte NOUN B-LF
macrophage NOUN I-LF
– PUNCT I-LF
colony NOUN I-LF
- PUNCT I-LF
stimulating VERB I-LF
factor NOUN I-LF
( PUNCT O
GM PROPN B-AC
– PUNCT B-AC
CSF PROPN B-AC
) PUNCT O
treatment NOUN O
( PUNCT O
S2C PROPN O
and CCONJ O
S2D PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

The DET O
positive ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
( PUNCT O
PPV PROPN B-AC
) PUNCT O
represents VERB O
the DET O
proportion NOUN O
of ADP O
test ADJ O
- PUNCT O
positive ADJ O
specimens NOUN O
that PRON O
truly ADV O
present VERB O
the DET O
target NOUN O
disorder NOUN O
, PUNCT O
while SCONJ O
the DET O
negative ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
( PUNCT O
NPV PROPN B-AC
) PUNCT O
represents VERB O
the DET O
proportion NOUN O
of ADP O
test ADJ O
- PUNCT O
negative ADJ O
specimens NOUN O
that PRON O
truly ADV O
do AUX O
not PART O
present VERB O
the DET O
target NOUN O
disorder NOUN O
: PUNCT O
and CCONJ O

Underlying VERB O
data NOUN O
for ADP O
Fig NOUN O
8 NUM O
can AUX O
be AUX O
found VERB O
in ADP O
S1 PROPN O
Data PROPN O
. PUNCT O
br PROPN B-AC
, PUNCT O
broad ADJ B-LF
; PUNCT O
d NOUN O
, PUNCT O
day NOUN O
; PUNCT O
Dcp-1 PROPN B-AC
, PUNCT O
Death PROPN B-LF
Caspase-1 PROPN I-LF
; PUNCT O
Dilp8 PROPN B-AC
, PUNCT O
Drosophila PROPN B-LF
Insulin PROPN I-LF
- PUNCT I-LF
like ADJ I-LF
peptide NOUN I-LF
8 NUM I-LF
; PUNCT O
EcRDN PROPN B-AC
, PUNCT O
dominant ADJ B-LF
negative ADJ I-LF
form NOUN I-LF
of ADP I-LF
ecdysone NOUN I-LF
receptor NOUN I-LF
; PUNCT O
egr NOUN B-AC
, PUNCT O
eiger NOUN B-LF
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
L3 PROPN B-AC
, PUNCT O
third ADJ B-LF
larval ADJ I-LF
stage NOUN I-LF
; PUNCT O
Mmp1 PROPN B-AC
, PUNCT O
Matrix PROPN B-LF
metalloprotease NOUN I-LF
1 NUM I-LF
; PUNCT O
RNAi PROPN B-AC
, PUNCT O
RNA NOUN B-LF
interference NOUN I-LF
; PUNCT O
rnts PROPN B-AC
, PUNCT O
rotund NOUN O
- PUNCT O
GAL4 PROPN O
, PUNCT O
tubulin NOUN O
- PUNCT O
GAL80thermo NOUN O
- PUNCT O
sensitive ADJ O
; PUNCT O
R0 PROPN B-AC
, PUNCT O
beginning NOUN B-LF
of ADP I-LF
the DET I-LF
recovery NOUN I-LF
period NOUN I-LF
; PUNCT O
vol NOUN B-AC
, PUNCT O
volume NOUN B-LF
; PUNCT O
Wg PROPN B-AC
, PUNCT O
Wingless PROPN B-LF
; PUNCT O
yw NOUN B-AC
, PUNCT O
yellow ADJ B-LF
, PUNCT I-LF
white ADJ I-LF
. PUNCT O

Abbreviations NOUN O
: PUNCT O
ddPCR NOUN O
, PUNCT O
droplet NOUN O
digital ADJ O
PCR NOUN O
; PUNCT O
preBötC NOUN B-AC
, PUNCT O
pre ADJ B-LF
- ADJ I-LF
Bötzinger ADJ I-LF
complex NOUN I-LF
; PUNCT O
shRNA NOUN B-AC
, PUNCT O
short ADJ B-LF
hairpin NOUN I-LF
RNA NOUN I-LF
; PUNCT O
Trp NOUN B-AC
, PUNCT O
transient ADJ B-LF
receptor NOUN I-LF
potential NOUN I-LF
. PUNCT O

For ADP O
underlying VERB O
data NOUN O
, PUNCT O
see VERB O
S1 PROPN O
Data PROPN O
file NOUN O
. PUNCT O
α PROPN B-AC
- PUNCT B-AC
SMA PROPN B-AC
, PUNCT O
alpha ADJ B-LF
- PUNCT I-LF
smooth ADJ I-LF
muscle NOUN I-LF
actin NOUN I-LF
; PUNCT O
CCl4 PROPN B-AC
, PUNCT O
carbon NOUN B-LF
tetrachloride NOUN I-LF
; PUNCT O
cIAP PROPN B-AC
, PUNCT O
cellular ADJ B-LF
inhibitor NOUN I-LF
of ADP I-LF
apoptosis NOUN I-LF
protein NOUN I-LF
; PUNCT O
Hgf PROPN B-AC
, PUNCT O
hepatocyte NOUN B-LF
growth NOUN I-LF
factor NOUN I-LF
; PUNCT O
med23 NOUN O
, PUNCT O
Mediator PROPN O
complex NOUN O
subunit NOUN O
23 NUM O
; PUNCT O
med23Δli NOUN B-AC
, PUNCT O
liver NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
knockout NOUN I-LF
of ADP I-LF
Med23 PROPN I-LF
; PUNCT O
med23f NOUN B-AC
/ SYM B-AC
f NOUN B-AC
, PUNCT O
med23 NOUN B-LF
- PUNCT I-LF
floxed VERB I-LF
; PUNCT O
PCNA PROPN B-AC
, PUNCT O
proliferating VERB B-LF
cell NOUN I-LF
nuclear ADJ I-LF
antigen NOUN I-LF
; PUNCT O
qRT NOUN B-AC
- PUNCT B-AC
PCR NOUN B-AC
, PUNCT O
quantitative ADJ B-LF
real ADJ I-LF
- PUNCT I-LF
time NOUN I-LF
PCR NOUN I-LF
. PUNCT O

GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
His2Av PROPN B-AC
, PUNCT O
histone NOUN B-LF
2A NOUN I-LF
variant NOUN I-LF
; PUNCT O
MTB PROPN O
, PUNCT O
mid NOUN O
- NOUN O
blastula NOUN O
transition NOUN O
; PUNCT O
RFP PROPN B-AC
, PUNCT O
red ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
Rif1 PROPN B-AC
, PUNCT O
Rap1 NOUN O
interacting VERB O
factor NOUN O
. PUNCT O

Kinesin PROPN B-LF
family NOUN I-LF
member NOUN I-LF
20A PROPN I-LF
( PUNCT O
KIF20A PROPN B-AC
, PUNCT O
also ADV O
known VERB O
as ADP O
RAB6KIFL PROPN O
) PUNCT O
belongs VERB O
to ADP O
kinesin PROPN O
superfamily-6 NOUN O
and CCONJ O
contains VERB O
a DET O
conserved ADJ O
motor NOUN O
domain NOUN O
. PUNCT O

BMI PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
IQR PROPN B-AC
, PUNCT O
interquartile ADJ B-LF
range NOUN I-LF
; PUNCT O
MCW PROPN O
, PUNCT O
married ADJ O
, PUNCT O
cohabitating VERB O
, PUNCT O
widowed VERB O
; PUNCT O
PedsQL PROPN O
, PUNCT O
Pediatric PROPN O
Quality PROPN O
of ADP O
Life PROPN O
Inventory PROPN O
; PUNCT O
SES PROPN B-AC
, PUNCT O
socioeconomic ADJ B-LF
status NOUN I-LF
; PUNCT O
SO PROPN O
, PUNCT O
single ADJ O
, PUNCT O
other ADJ O
; PUNCT O
SRH PROPN B-AC
, PUNCT O
sexual ADJ B-LF
and CCONJ I-LF
reproductive ADJ I-LF
health NOUN I-LF
. PUNCT O

F PROPN B-AC
- PUNCT B-AC
actin NOUN B-AC
, PUNCT O
filamentous ADJ B-LF
actin NOUN I-LF
; PUNCT O
HEK PROPN B-AC
, PUNCT O
human ADJ B-LF
embryonic ADJ I-LF
kidney NOUN I-LF
; PUNCT O
MBP PROPN B-AC
, PUNCT O
maltose NOUN B-LF
- PUNCT I-LF
binding VERB I-LF
protein NOUN I-LF
; PUNCT O
pel NOUN O
, PUNCT O
pellet NOUN O
; PUNCT O
sup NOUN O
, PUNCT O
supernatant NOUN O
; PUNCT O
TccC3HVR PROPN B-AC
, PUNCT O
hypervariable ADJ B-LF
region NOUN I-LF
of ADP I-LF
TccC3 PROPN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

Two NUM O
developments NOUN O
facilitated VERB O
the DET O
shift NOUN O
to ADP O
the DET O
outpatient NOUN O
model NOUN O
: PUNCT O
first ADV O
, PUNCT O
the DET O
introduction NOUN O
of ADP O
mid ADJ B-LF
- PUNCT I-LF
upper ADJ I-LF
arm NOUN I-LF
circumference NOUN I-LF
( PUNCT O
MUAC PROPN B-AC
) PUNCT O
as ADP O
an DET O
additional ADJ O
diagnostic ADJ O
tool NOUN O
; PUNCT O
this DET O
change NOUN O
made VERB O
case NOUN O
detection NOUN O
by ADP O
CHWs PROPN B-AC
more ADV O
convenient ADJ O
and CCONJ O
affordable ADJ O
than ADP O
using VERB O
weight NOUN B-LF
- PUNCT I-LF
for ADP I-LF
- PUNCT I-LF
length NOUN I-LF
Z NOUN I-LF
- PUNCT I-LF
scores NOUN I-LF
( PUNCT O
WLZs PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
require VERB O
the DET O
measurement NOUN O
of ADP O
both CCONJ O
weight NOUN O
and CCONJ O
length NOUN O
. PUNCT O

CI PROPN O
, PUNCT O
confidence NOUN O
interval NOUN O
; PUNCT O
OR PROPN B-AC
, PUNCT O
odds NOUN B-LF
ratio NOUN I-LF
. PUNCT O

AW PROPN B-AC
, PUNCT O
active ADJ B-LF
wake NOUN I-LF
; PUNCT O
cMC NOUN B-AC
, PUNCT O
caudal ADJ B-LF
medial ADJ I-LF
cortex NOUN I-LF
; PUNCT O
ECG PROPN B-AC
, PUNCT O
electrocardiogram NOUN B-LF
; PUNCT O
EMG PROPN B-AC
, PUNCT O
electromyogram NOUN B-LF
; PUNCT O
EOG PROPN B-AC
, PUNCT O
electro NOUN B-LF
- NOUN I-LF
oculogram NOUN I-LF
; PUNCT O
LFP PROPN B-AC
, PUNCT O
local ADJ B-LF
field NOUN I-LF
potential NOUN I-LF
; PUNCT O
QW PROPN B-AC
, PUNCT O
quiet ADJ B-LF
wake NOUN I-LF
. PUNCT O

EEA1 PROPN B-AC
, PUNCT O
early ADJ B-LF
endosome NOUN I-LF
antigen NOUN I-LF
1 NUM I-LF
; PUNCT O
FCHSD2 PROPN B-AC
, PUNCT O
FCH PROPN B-LF
/ SYM I-LF
F PROPN I-LF
- PUNCT I-LF
BAR PROPN I-LF
and CCONJ I-LF
Double PROPN I-LF
SH3 PROPN I-LF
Domain PROPN I-LF
- PUNCT I-LF
Containing PROPN I-LF
Protein PROPN I-LF
; PUNCT O
LAMP1 PROPN B-AC
, PUNCT O
lysosome NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
membrane NOUN I-LF
glycoprotein NOUN I-LF
1 NUM I-LF
; PUNCT O
MET PROPN B-AC
, PUNCT O
proto NOUN B-LF
- PUNCT I-LF
oncogene NOUN I-LF
c NOUN I-LF
- PUNCT I-LF
Met PROPN I-LF
; PUNCT O
siCtrl PROPN O
, PUNCT O
control NOUN O
siRNA NOUN B-AC
; PUNCT O
siRNA NOUN B-AC
, PUNCT O
small ADJ B-LF
interfering VERB I-LF
RNA NOUN I-LF
. PUNCT O

We PRON O
carried VERB O
out ADP O
systematic ADJ O
experiments NOUN O
to PART O
determine VERB O
if SCONJ O
the DET O
peptide NOUN O
detergents NOUN O
A6 PROPN B-AC
K PROPN B-AC
( PUNCT O
molecular ADJ O
weight NOUN O
= PUNCT O
615 NUM O
Da NOUN O
, PUNCT O
CAC NOUN B-AC
= PUNCT O
1.6 NUM O
mM NOUN O
in ADP O
water NOUN O
, PUNCT O
approximately ADV O
0.23 NUM O
mM NOUN O
in ADP O
phosphate NOUN B-LF
- PUNCT I-LF
buffered VERB I-LF
saline NOUN I-LF
[ PUNCT O
PBS PROPN B-AC
] PUNCT O
) PUNCT O
and CCONJ O
acetyl NOUN B-LF
- PUNCT I-LF
VVVVVVD NOUN I-LF
( PUNCT O
V6D PROPN B-AC
) PUNCT O
( PUNCT O
molecular ADJ O
weight NOUN O
= PUNCT O
783 NUM O
Da NOUN O
, PUNCT O
CAC NOUN B-AC
= PUNCT O
0.7 NUM O
mM NOUN O
in ADP O
water NOUN O
, PUNCT O
approximately ADV O
0.1 NUM O
mM NOUN O
in ADP O
PBS PROPN B-AC
) PUNCT O
could AUX O
stabilize VERB O
PS PROPN B-AC
- PUNCT B-AC
I PROPN B-AC
complex NOUN O
during ADP O
the DET O
drying VERB O
process NOUN O
. PUNCT O

The DET O
XRD NOUN O
scan NOUN O
of ADP O
the DET O
synthesized VERB O
AuNPs PROPN B-AC
showed VERB O
a DET O
significant ADJ O
diffraction NOUN O
peak NOUN O
at ADP O
2θ NOUN O
angle NOUN O
: PUNCT O
38.1 NUM O
° NOUN O
corresponding VERB O
to ADP O
111crystal NOUN O
plane NOUN O
of ADP O
face NOUN O
- PUNCT O
centered VERB O
gold NOUN O
in ADP O
the DET O
nanoparticles NOUN B-LF
solution NOUN O
made VERB O
from ADP O
metabolites NOUN O
extracted VERB O
from ADP O
mammalian ADJ O
cells NOUN O
( PUNCT O
AuNP2 PROPN O
and CCONJ O
AuNP4 PROPN O
) PUNCT O
, PUNCT O
but CCONJ O
not PART O
from ADP O
metabolites NOUN O
solution NOUN O
extracted VERB O
from ADP O
cell NOUN O
- PUNCT O
free ADJ O
supernatants NOUN O
or CCONJ O
PBS PROPN O
solution NOUN O
, PUNCT O
employed VERB O
as ADP O
control NOUN O
( PUNCT O
Fig NOUN O
4A NUM O
) PUNCT O
. PUNCT O
The DET O
formation NOUN O
of ADP O
AuNPs PROPN B-AC
was AUX O
confirmed VERB O
by ADP O
the DET O
energy NOUN O
dispersive ADJ O
spectroscopy NOUN O
( PUNCT O
EDS PROPN O
) PUNCT O
( PUNCT O
Fig NOUN O
4B NUM O
) PUNCT O
. PUNCT O
The DET O
EDS PROPN O
profile NOUN O
showed VERB O
a DET O
strong ADJ O
Au3 NOUN O
+ NOUN O
signal NOUN O
from ADP O
the DET O
NPs PROPN B-AC
solution NOUN O
made VERB O
from ADP O
the DET O
metabolites NOUN O
extracted VERB O
from ADP O
mammalian ADJ O
cells NOUN O
. PUNCT O

However ADV O
, PUNCT O
EUS PROPN B-AC
is AUX O
a DET O
tedious ADJ O
procedure NOUN O
, PUNCT O
with ADP O
poor ADJ O
image NOUN O
and CCONJ O
inter ADJ O
- PUNCT O
observer ADJ O
variation NOUN O
for ADP O
the DET O
staging NOUN O
of ADP O
EGC PROPN B-AC
, PUNCT O
compared VERB O
with ADP O
conventional ADJ O
white ADJ B-LF
- PUNCT I-LF
light NOUN I-LF
endoscopy NOUN I-LF
( PUNCT O
WLE PROPN B-AC
) PUNCT O
[ PUNCT O
8 NUM O
] PUNCT O
. PUNCT O

UPRmt NOUN B-AC
, PUNCT O
mitochondrial ADJ O
unfolded VERB B-LF
protein NOUN I-LF
response NOUN I-LF
. PUNCT O

Samples NOUN O
were AUX O
analyzed VERB O
for ADP O
serum ADJ O
β ADJ B-LF
- ADJ I-LF
aminoisobutyric ADJ I-LF
acid NOUN I-LF
( PUNCT O
BAIB NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
urine NOUN O
for ADP O
cystatin NOUN O
B NOUN O
and CCONJ O
clusterin NOUN O
. PUNCT O

The DET O
decolorization NOUN O
of ADP O
azobenzene NOUN O
( PUNCT O
AZ PROPN B-AC
) PUNCT O
and CCONJ O
azo NOUN O
dyes NOUN O
( PUNCT O
RR241 NOUN O
, PUNCT O
methyl NOUN B-LF
red NOUN I-LF
( PUNCT O
MR PROPN B-AC
) PUNCT O
and CCONJ O
congo NOUN B-LF
red NOUN I-LF
( PUNCT O
CR NOUN B-AC
) PUNCT O
by ADP O
the DET O
purified VERB O
enzyme NOUN O
was AUX O
investigated VERB O
under ADP O
varying VERB O
conditions NOUN O
. PUNCT O

Values NOUN O
for ADP O
each DET O
data NOUN O
point NOUN O
can AUX O
be AUX O
found VERB O
in ADP O
S1 PROPN O
Data PROPN O
. PUNCT O
3 NUM B-AC
M NOUN B-AC
, PUNCT O
3 NUM B-LF
months NOUN I-LF
old ADJ I-LF
; PUNCT O
26 NUM B-AC
M NOUN B-AC
, PUNCT O
26 NUM B-LF
months NOUN I-LF
old ADJ I-LF
; PUNCT O
AV PROPN O
, PUNCT O
atrioventricular ADJ O
; PUNCT O
Cisd2 PROPN O
, PUNCT O
CDGSH PROPN O
iron NOUN O
- PUNCT O
sulfur NOUN O
domain NOUN O
- PUNCT O
containing VERB O
protein NOUN O
2 NUM O
; PUNCT O
Cx43 PROPN B-AC
, PUNCT O
Connexin PROPN B-LF
43 NUM I-LF
; PUNCT O
DCF PROPN B-AC
, PUNCT O
2′ NUM B-LF
, PUNCT I-LF
7′-dichlorofluorescein NOUN I-LF
; PUNCT O
ECG PROPN B-AC
, PUNCT O
electrocardiography NOUN B-LF
; PUNCT O
Gapdh PROPN B-AC
, PUNCT O
glyceraldehyde NOUN B-LF
3 NUM I-LF
- PUNCT I-LF
phosphate NOUN I-LF
dehydrogenase NOUN I-LF
; PUNCT O
IF PROPN B-AC
, PUNCT O
immunofluorescence NOUN B-LF
; PUNCT O
LV PROPN B-AC
, PUNCT O
left ADJ B-LF
ventricle NOUN I-LF
; PUNCT O
MRI PROPN B-AC
, PUNCT O
magnetic ADJ O
resonance NOUN O
image NOUN O
; PUNCT O
RNS PROPN B-AC
, PUNCT O
reactive ADJ B-LF
nitrogen NOUN I-LF
species NOUN I-LF
; PUNCT O
ROS PROPN B-AC
, PUNCT O
reactive ADJ B-LF
oxygen NOUN I-LF
species NOUN I-LF
; PUNCT O
Serca2a PROPN B-AC
, PUNCT O
sarco NOUN B-LF
/ SYM I-LF
endoplasmic ADJ I-LF
reticulum NOUN I-LF
Ca2 NOUN I-LF
+ NOUN I-LF
-ATPase NOUN I-LF
; PUNCT O
TBQ PROPN B-AC
, PUNCT O
2,5 NUM B-LF
- PUNCT I-LF
Di NOUN I-LF
- PUNCT I-LF
tert NOUN I-LF
- PUNCT I-LF
butylhydroquinone NOUN I-LF
; PUNCT O
TEM PROPN B-AC
, PUNCT O
transmission NOUN B-LF
electron NOUN I-LF
microscopy NOUN I-LF
; PUNCT O
TG PROPN B-AC
, PUNCT O
transgenic ADJ B-LF
; PUNCT O
WGA PROPN O
, PUNCT O
wheat NOUN O
germ NOUN O
agglutinin NOUN O
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
type NOUN I-LF
. PUNCT O

Principal ADJ B-LF
coordinate NOUN I-LF
analysis NOUN I-LF
( PUNCT O
PCoA PROPN B-AC
) PUNCT O
plots NOUN O
for ADP O
unweighted ADJ O
UniFrac PROPN O
distances NOUN O
and CCONJ O
Bray PROPN O
Curtis PROPN O
dissimilarities NOUN O
were AUX O
generated VERB O
with ADP O
QIIME2 PROPN O
. PUNCT O
The DET O
ANOSIM PROPN B-AC
( PUNCT O
Analysis PROPN B-LF
of ADP I-LF
Similarity PROPN I-LF
) PUNCT O
test NOUN O
within ADP O
PRIMER PROPN O
6 NUM O
software NOUN O
package NOUN O
( PUNCT O
PRIMER PROPN O
- PUNCT O
E PROPN O
Ltd. PROPN O
, PUNCT O
Luton PROPN O
, PUNCT O
UK PROPN O
) PUNCT O
was AUX O
performed VERB O
on ADP O
the DET O
weighted ADJ O
and CCONJ O
unweighted ADJ O
UniFrac PROPN O
and CCONJ O
Bray PROPN O
Curtis PROPN O
distance NOUN O
metrics NOUN O
to PART O
find VERB O
significant ADJ O
differences NOUN O
in ADP O
microbial ADJ O
communities NOUN O
between ADP O
groups NOUN O
. PUNCT O

Significantly ADV O
, PUNCT O
gp95 PROPN O
’s PART O
stimulation NOUN O
of ADP O
NMDARs NOUN B-AC
activates VERB O
cGMP NOUN B-LF
- PUNCT I-LF
dependent ADJ I-LF
protein NOUN I-LF
kinase NOUN I-LF
II NUM I-LF
( PUNCT O
cGKII PROPN B-AC
) PUNCT O
through ADP O
the DET O
activation NOUN O
of ADP O
the DET O
neuronal ADJ B-LF
nitric NOUN I-LF
oxide NOUN I-LF
synthase NOUN I-LF
( PUNCT O
nNOS)-cGMP NOUN B-AC
pathway NOUN O
, PUNCT O
which PRON O
increases VERB O
Ca2 NOUN O
+ NOUN O
release NOUN O
from ADP O
the DET O
ER NOUN B-AC
and CCONJ O
promotes VERB O
surface NOUN O
expression NOUN O
of ADP O
AMPA PROPN O
receptors NOUN O
, PUNCT O
leading VERB O
to ADP O
an DET O
increase NOUN O
in ADP O
synaptic ADJ O
activity NOUN O
. PUNCT O

As SCONJ O
shown VERB O
in ADP O
Fig NOUN O
1 NUM O
( PUNCT O
and CCONJ O
in ADP O
S1 PROPN O
Table PROPN O
) PUNCT O
, PUNCT O
these PRON O
included VERB O
plasma NOUN O
IgA PROPN O
anti ADJ O
- PUNCT O
LPS PROPN B-AC
antibody NOUN O
, PUNCT O
zonulin NOUN O
( PUNCT O
in ADP O
all DET O
children NOUN O
for ADP O
WAZ PROPN B-AC
and CCONJ O
, PUNCT O
for ADP O
HAZ PROPN B-AC
in ADP O
children NOUN O
> NUM O
12 NUM O
months NOUN O
old ADJ O
) PUNCT O
, PUNCT O
and CCONJ O
I PROPN B-AC
- PUNCT B-AC
FABP PROPN B-AC
. PUNCT O
IgA PROPN O
anti ADJ O
- PUNCT O
flagellin ADJ O
and CCONJ O
anti ADJ O
- PUNCT O
LPS PROPN B-AC
antibodies NOUN O
( PUNCT O
n NOUN O
= SYM O
292 NUM O
; PUNCT O
r NOUN O
= SYM O
0.15 NUM O
, PUNCT O
p NOUN O
= SYM O
0.011 NUM O
and CCONJ O
r NOUN O
= SYM O
0.14 NUM O
, PUNCT O
p NOUN O
= SYM O
0.017 NUM O
) PUNCT O
as ADP O
well ADV O
as ADP O
intestinal ADJ B-LF
fatty NOUN I-LF
acid NOUN I-LF
binding VERB I-LF
protein NOUN I-LF
( PUNCT O
I PROPN B-AC
- PUNCT B-AC
FABP PROPN B-AC
; PUNCT O
n NOUN O
= SYM O
281 NUM O
; PUNCT O
r NOUN O
= SYM O
0.14 NUM O
; PUNCT O
p NOUN O
= SYM O
0.024 NUM O
) PUNCT O
associate VERB O
with ADP O
worse ADJ O
stunting NOUN O
( PUNCT O
i.e. X O
lower ADJ O
HAZ PROPN B-AC
SS PROPN O
scores NOUN O
) PUNCT O
at ADP O
the DET O
time NOUN O
of ADP O
enrollment NOUN O
, PUNCT O
suggesting VERB O
greater ADJ O
prior ADJ O
exposure NOUN O
to ADP O
LPS PROPN B-AC
and CCONJ O
release NOUN O
of ADP O
an DET O
intestinal ADJ O
cytosolic ADJ O
protein NOUN O
, PUNCT O
thus ADV O
enterocyte NOUN O
damage NOUN O
, PUNCT O
respectively ADV O
. PUNCT O

While SCONJ O
using VERB O
fluorescence NOUN B-LF
in ADP I-LF
situ NOUN I-LF
hybridization NOUN I-LF
( PUNCT O
FISH PROPN B-AC
) PUNCT O
to PART O
visualize VERB O
the DET O
Xic NOUN B-AC
in ADP O
female ADJ O
ES NOUN B-AC
cells NOUN O
fixed VERB O
with ADP O
paraformaldehyde NOUN B-LF
( PUNCT O
PFA PROPN B-AC
) PUNCT O
, PUNCT O
we PRON O
observed VERB O
that SCONJ O
a DET O
high ADJ O
frequency NOUN O
of ADP O
cells NOUN O
displayed VERB O
a DET O
single ADJ O
pinpoint NOUN O
FISH PROPN B-AC
signal NOUN O
at ADP O
one NUM O
allele NOUN O
and CCONJ O
a DET O
double ADJ O
pinpoint NOUN O
at ADP O
the DET O
other ADJ O
. PUNCT O

In ADP O
the DET O
foreseeable ADJ O
future NOUN O
, PUNCT O
patients NOUN O
with ADP O
hepatitis PROPN B-LF
C PROPN I-LF
virus NOUN I-LF
( PUNCT O
HCV PROPN B-AC
) PUNCT O
with ADP O
good ADJ O
healthcare NOUN O
access NOUN O
will AUX O
all PRON O
have AUX O
been AUX O
cured VERB O
and CCONJ O
the DET O
lost VERB B-LF
to PART I-LF
follow VERB I-LF
- PUNCT I-LF
up ADP I-LF
( PUNCT O
LFU PROPN B-AC
) PUNCT O
HCV PROPN B-AC
- PUNCT O
population NOUN O
will AUX O
increasingly ADV O
exist VERB O
of ADP O
hard ADJ O
- PUNCT O
to PART O
- PUNCT O
reach VERB O
patients NOUN O
. PUNCT O

The DET O
most ADV O
recent ADJ O
IA PROPN B-AC
- PUNCT O
based VERB O
challenge NOUN O
by ADP O
a DET O
tobacco NOUN O
company NOUN O
( PUNCT O
of ADP O
which PRON O
we PRON O
are AUX O
aware ADJ O
) PUNCT O
was AUX O
to PART O
write VERB O
to PART O
the DET O
Chairman PROPN O
of ADP O
the DET O
European PROPN O
Commission PROPN O
's PART O
internal ADJ O
Impact PROPN B-LF
Assessment PROPN I-LF
Board PROPN O
in ADP O
July PROPN O
2008 NUM O
to PART O
complain VERB O
that SCONJ O
the DET O
IA PROPN B-AC
on ADP O
smoke NOUN O
- PUNCT O
free ADJ O
environments NOUN O
, PUNCT O
which PRON O
has VERB O
yet ADV O
to PART O
be AUX O
published VERB O
, PUNCT O
did AUX O
not PART O
fully ADV O
comply VERB O
with ADP O
the DET O
European PROPN O
Commission PROPN O
's PART O
IA PROPN B-AC
guidelines NOUN O
and CCONJ O
that SCONJ O
the DET O
process NOUN O
of ADP O
stakeholder NOUN O
consultation NOUN O
was AUX O
inadequate ADJ O
[ PUNCT O
245 NUM O
] PUNCT O
. PUNCT O

Cardiovascular ADJ O
diseases NOUN O
are AUX O
one NUM O
of ADP O
the DET O
most ADV O
common ADJ O
causes NOUN O
of ADP O
death NOUN O
and CCONJ O
disability NOUN O
in ADP O
low- ADJ B-LF
and CCONJ I-LF
middle ADJ I-LF
- PUNCT I-LF
income NOUN I-LF
countries NOUN I-LF
( PUNCT O
LMICs PROPN B-AC
) PUNCT O
. PUNCT O

We PRON O
assessed VERB O
circulating VERB O
miRNAs NOUN B-AC
of ADP O
patients NOUN O
with ADP O
familial ADJ B-LF
adenomatous ADJ I-LF
polyposis NOUN I-LF
( PUNCT O
FAP PROPN B-AC
) PUNCT O
as ADP O
a DET O
hereditary ADJ O
disease NOUN O
and CCONJ O
prototype NOUN O
of ADP O
colorectal ADJ O
cancer NOUN O
progression NOUN O
. PUNCT O

The DET O
optimum ADJ O
cut NOUN O
- PUNCT O
points NOUN O
for ADP O
determining VERB O
6 NUM O
- PUNCT O
mo NOUN O
TTP NOUN B-AC
were AUX O
identified VERB O
using VERB O
receiver NOUN B-LF
operating NOUN I-LF
characteristic NOUN I-LF
( PUNCT O
ROC PROPN B-AC
) PUNCT O
curves NOUN O
. PUNCT O

In ADP O
support NOUN O
of ADP O
this DET O
notion NOUN O
, PUNCT O
Oshima PROPN O
and CCONJ O
colleagues NOUN O
reported VERB O
that SCONJ O
vestibular ADJ O
hair NOUN O
cell NOUN O
- PUNCT O
like ADJ O
cells NOUN O
differentiated VERB O
in ADP O
vitro ADJ O
from ADP O
mouse NOUN O
embryonic ADJ B-LF
stem NOUN I-LF
( PUNCT O
ES PROPN B-AC
) PUNCT O
and CCONJ O
iPS PROPN B-AC
cells NOUN O
acquired VERB O
mechanosensitivity NOUN O
and CCONJ O
stereocilia NOUN O
with ADP O
certain ADJ O
mature ADJ O
features NOUN O
( PUNCT O
e.g. X O
staircase NOUN O
pattern NOUN O
) PUNCT O
, PUNCT O
but CCONJ O
relatively ADV O
immature ADJ O
basolateral ADJ O
ion NOUN O
channel NOUN O
properties NOUN O
[ PUNCT O
20 NUM O
] PUNCT O
. PUNCT O

Recent ADJ O
chromatin NOUN B-LF
immunoprecipitation NOUN I-LF
sequencing NOUN I-LF
( PUNCT O
ChIP PROPN B-AC
- PUNCT B-AC
seq NOUN B-AC
) PUNCT O
studies NOUN O
have AUX O
shown VERB O
that SCONJ O
many ADJ O
of ADP O
these DET O
inputs NOUN O
are AUX O
direct ADJ O
[ PUNCT O
64 NUM O
] PUNCT O
. PUNCT O

SDF NOUN B-AC
, PUNCT O
spike NOUN B-LF
density NOUN I-LF
function NOUN I-LF
. PUNCT O

In ADP O
most ADJ O
experiments NOUN O
the DET O
analysis NOUN O
was AUX O
performed VERB O
using VERB O
two NUM O
sets NOUN O
of ADP O
primers NOUN O
: PUNCT O
one NUM O
set NOUN O
encompassed VERB O
the DET O
core NOUN O
promoter NOUN O
, PUNCT O
transcription NOUN O
start NOUN O
site NOUN O
, PUNCT O
and CCONJ O
immediate ADJ O
downstream ADV O
region NOUN O
, PUNCT O
and CCONJ O
a DET O
second ADJ O
set NOUN O
was AUX O
located VERB O
far ADV O
downstream ADV O
of ADP O
the DET O
transcription NOUN O
start NOUN O
site NOUN O
, PUNCT O
within ADP O
the DET O
open ADJ B-LF
reading NOUN I-LF
frame NOUN I-LF
( PUNCT O
ORF PROPN B-AC
) PUNCT O
. PUNCT O

BMI NOUN B-AC
= PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF

The DET O
angiomotin PROPN B-LF
( PUNCT O
Amot)–Yes PROPN B-LF
- PUNCT I-LF
associated VERB I-LF
protein NOUN I-LF
1 NUM I-LF
( PUNCT O
Yap1 PROPN B-AC
) PUNCT O
complex NOUN O
plays VERB O
a DET O
major ADJ O
role NOUN O
in ADP O
regulating VERB O
the DET O
inhibition NOUN O
of ADP O
cell NOUN O
contact NOUN O
, PUNCT O
cellular ADJ O
polarity NOUN O
, PUNCT O
and CCONJ O
cell NOUN O
growth NOUN O
in ADP O
many ADJ O
cell NOUN O
types NOUN O
. PUNCT O

Importantly ADV O
, PUNCT O
the DET O
Western ADJ O
cohort NOUN O
studies NOUN O
demonstrated VERB O
that SCONJ O
metabolic ADJ O
health NOUN O
changed VERB O
over ADP O
time NOUN O
across ADP O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT O
BMI PROPN B-AC
) PUNCT O
categories NOUN O
and CCONJ O
was AUX O
associated VERB O
with ADP O
cardiovascular ADJ O
risk NOUN O
[ PUNCT O
9 NUM O
, PUNCT O
23 NUM O
] PUNCT O
. PUNCT O

The DET O
area NOUN B-LF
under ADP I-LF
the DET I-LF
curve NOUN I-LF
( PUNCT O
AUC PROPN B-AC
) PUNCT O
was AUX O
calculated VERB O
as ADP O
the DET O
sum NOUN O
of ADP O
the DET O
relative ADJ B-LF
enhancement NOUN I-LF
( PUNCT O
RE PROPN B-AC
) PUNCT O
at ADP O
each DET O
time NOUN O
- ADJ O
point NOUN O
during ADP O
DCE PROPN B-AC
- ADJ B-AC
MRI NOUN B-AC
. PUNCT O
RE PROPN B-AC
at ADP O
a DET O
given VERB O
time NOUN O
- ADJ O
point NOUN O
is AUX O
defined VERB O
as ADP O
: PUNCT O
REt=(SIt PROPN O
- ADJ O
SI0)/SI0×100%(1 NUM O
) PUNCT O
where SCONJ O
SI0 PROPN O
is AUX O
the DET O
average ADJ O
pre ADJ O
- ADJ O
contrast ADJ O
MR PROPN B-AC
signal NOUN O
intensity NOUN O
and CCONJ O
SIt PROPN O
is AUX O
the DET O
MR PROPN B-AC
signal NOUN O
intensity NOUN O
at ADP O
time NOUN O
t. PUNCT O

Fragments NOUN B-LF
per ADP I-LF
kilobase NOUN I-LF
of ADP I-LF
transcript NOUN I-LF
per ADP I-LF
million NUM I-LF
mapped VERB I-LF
reads NOUN I-LF
( PUNCT O
FPKMs PROPN B-AC
) PUNCT O
expression NOUN O
data NOUN O
of ADP O
miRNA NOUN O
targets NOUN O
were AUX O
generated VERB O
from ADP O
our PRON O
previous ADJ O
study NOUN O
using VERB O
RNA NOUN O
sequencing NOUN O
[ PUNCT O
52 NUM O
] PUNCT O
. PUNCT O

In ADP O
this DET O
current ADJ O
study NOUN O
, PUNCT O
we PRON O
developed VERB O
a DET O
novel ADJ O
high ADJ O
- PUNCT O
throughput NOUN O
platform NOUN O
for ADP O
quantifying VERB O
FGF23 NOUN B-AC
, PUNCT O
used VERB O
a DET O
clinically ADV O
utilised VERB O
platform NOUN O
for ADP O
N NOUN B-LF
- PUNCT I-LF
terminal ADJ I-LF
pro ADJ I-LF
- PUNCT I-LF
B NOUN I-LF
- PUNCT I-LF
type NOUN I-LF
natriuretic ADJ I-LF
peptide NOUN I-LF
( PUNCT O
NT NOUN B-AC
- PUNCT B-AC
proBNP NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
quantified VERB O
these DET O
biomarkers NOUN O
in ADP O
the DET O
previously ADV O
tested VERB O
patients NOUN O
, PUNCT O
as ADP O
well ADV O
as ADP O
in ADP O
an DET O
unselected ADJ O
independent ADJ O
cohort NOUN O
of ADP O
patients NOUN O
presenting VERB O
to ADP O
hospital NOUN O
, PUNCT O
for ADP O
validation NOUN O
. PUNCT O

We PRON O
tested VERB O
for ADP O
an DET O
impact NOUN O
of ADP O
the DET O
proportion NOUN O
of ADP O
species NOUN O
in ADP O
a DET O
clade NOUN O
that PRON O
breed VERB O
exclusively ADV O
in ADP O
the DET O
tropics NOUN O
on ADP O
model NOUN O
support NOUN O
and CCONJ O
parameter NOUN O
estimates NOUN O
in ADP O
single ADJ O
- PUNCT O
regime NOUN O
models NOUN O
by ADP O
conducting VERB O
phylogenetic ADJ B-LF
generalized VERB I-LF
least ADJ I-LF
squares NOUN I-LF
( PUNCT O
PGLS PROPN B-AC
) PUNCT O
using VERB O
the DET O
pgls NOUN O
function NOUN O
in ADP O
the DET O
R PROPN O
package NOUN O
caper NOUN O
[ PUNCT O
89 NUM O
] PUNCT O
, PUNCT O
estimating VERB O
phylogenetic ADJ O
signal NOUN O
( PUNCT O
λ NOUN O
) PUNCT O
using VERB O
ML NOUN B-AC
optimization NOUN O
, PUNCT O
constraining VERB O
values NOUN O
to ADP O
0 NUM O
≤ SYM O
λ NOUN O
≤ SYM O
1 NUM O
. PUNCT O

Stocks NOUN O
of ADP O
wild ADJ O
- PUNCT O
type NOUN O
Smith PROPN O
Strain PROPN O
MCMV PROPN B-AC
salivary ADJ O
gland NOUN O
extracts NOUN O
[ X O
14 NUM O
] PUNCT O
and CCONJ O
bacterial ADJ B-LF
artificial ADJ I-LF
chromosome NOUN I-LF
( PUNCT O
BAC)-derived PROPN B-AC
wild ADJ O
- PUNCT O
type NOUN O
, PUNCT O
DN PROPN O
- PUNCT O
SCP PROPN O
- PUNCT O
MCMV PROPN B-AC
[ X O
44 NUM O
] PUNCT O
, PUNCT O
Δm157 NOUN O
- PUNCT O
MCMV PROPN B-AC
, PUNCT O
and CCONJ O
m157 NOUN O
- PUNCT O
revertant NOUN O
were AUX O
prepared VERB O
as SCONJ O
previously ADV O
described VERB O
[ X O
73 NUM O
] PUNCT O
. PUNCT O

DIC PROPN B-AC
, PUNCT O
differential ADJ B-LF
interference NOUN I-LF
contrast NOUN I-LF
; PUNCT O
FUS PROPN B-AC
, PUNCT O
Fused VERB B-LF
in ADP I-LF
sarcoma NOUN I-LF
. PUNCT O

Pro ADJ O
- NOUN O
inflammatory ADJ O
cytokines NOUN O
, PUNCT O
such ADJ O
as ADP O
TNF NOUN B-AC
- NOUN O
α NOUN O
and CCONJ O
IL-6 NOUN B-AC
, PUNCT O
have AUX O
been AUX O
shown VERB O
to PART O
increase VERB O
in ADP O
the DET O
liver NOUN O
of ADP O
carbon NOUN B-LF
tetrachloride NOUN I-LF
( PUNCT O
CCl4)-induced NOUN B-AC
hepatitis NOUN O
[ PUNCT O
13 NUM O
] PUNCT O
. PUNCT O

CSF PROPN O
, PUNCT O
cerebrospinal ADJ O
fluid NOUN O
; PUNCT O
HLA PROPN B-AC
, PUNCT O
human ADJ B-LF
leucocyte NOUN I-LF
antigen NOUN I-LF
. PUNCT O

Kidney NOUN O
function NOUN O
was AUX O
assessed VERB O
using VERB O
point NOUN B-LF
- PUNCT I-LF
of ADP I-LF
- PUNCT I-LF
care NOUN I-LF
( PUNCT O
POC PROPN B-AC
) PUNCT O
tests NOUN O
that PRON O
included VERB O
a DET O
test NOUN O
strip NOUN O
for ADP O
measuring VERB O
creatinine NOUN O
level NOUN O
in ADP O
the DET O
blood NOUN O
using VERB O
a DET O
portable ADJ O
device NOUN O
and CCONJ O
a DET O
urine NOUN O
dipstick NOUN O
test NOUN O
to PART O
evaluate VERB O
for ADP O
proteinuria NOUN O
. PUNCT O

We PRON O
studied VERB O
the DET O
effects NOUN O
of ADP O
vernalization NOUN O
, PUNCT O
ambient ADJ O
growth NOUN O
temperature NOUN O
, PUNCT O
and CCONJ O
photoperiod NOUN O
, PUNCT O
using VERB O
four NUM O
different ADJ O
environments NOUN O
: PUNCT O
23 NUM B-LF
° NOUN I-LF
C NOUN I-LF
long ADJ I-LF
days NOUN I-LF
( PUNCT O
23LD NUM B-AC
) PUNCT O
, PUNCT O
16 NUM B-LF
° NOUN I-LF
C NOUN I-LF
long ADJ I-LF
days NOUN I-LF
( PUNCT O
16LD NUM B-AC
) PUNCT O
, PUNCT O
16 NUM B-LF
° NOUN I-LF
C NOUN I-LF
long ADJ I-LF
days NOUN I-LF
after ADP I-LF
5 NUM I-LF
wk NOUN I-LF
vernalization NOUN I-LF
( PUNCT O
16LDV NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
23 NUM B-LF
° NOUN I-LF
C NOUN I-LF
short ADJ I-LF
days NOUN I-LF
( PUNCT O
23SD NUM B-AC
) PUNCT O
. PUNCT O
DTF PROPN B-AC
and CCONJ O
TLN PROPN O
data NOUN O
from ADP O
155 NUM O
wild ADJ O
strains NOUN O
, PUNCT O
along ADP O
with ADP O
the DET O
common ADJ O
laboratory NOUN O
strains NOUN O
Col-0 PROPN B-AC
and CCONJ O
Ler PROPN B-AC
and CCONJ O
32 NUM O
flowering ADJ O
time NOUN O
mutants NOUN O
in ADP O
Col-0 PROPN B-AC
or CCONJ O
Ler PROPN B-AC
backgrounds NOUN O
, PUNCT O
passed VERB O
our PRON O
quality NOUN O
controls NOUN O
in ADP O
at ADV O
least ADV O
two NUM O
conditions NOUN O
. PUNCT O

Aussie PROPN B-AC
- PUNCT B-AC
FIT PROPN B-AC
, PUNCT O
Australian ADJ B-LF
Fans NOUN I-LF
in ADP I-LF
Training NOUN I-LF
; PUNCT O
CONSORT PROPN B-AC
, PUNCT O
Consolidated VERB B-LF
Standards NOUN I-LF
of ADP I-LF
Reporting NOUN I-LF
Trials NOUN I-LF
. PUNCT O

EIA NOUN B-AC
- NOUN O
positive ADJ O
samples NOUN O
were AUX O
cultured VERB O
[ PUNCT O
14 NUM O
] PUNCT O
and CCONJ O
C. NOUN O
difficile ADJ O
isolates NOUN O
genotyped VERB O
by ADP O
multi ADJ B-LF
- NOUN I-LF
locus NOUN I-LF
sequence NOUN I-LF
typing NOUN I-LF
( PUNCT O
MLST NOUN B-AC
) PUNCT O
[ PUNCT O
14 NUM O
] PUNCT O
. PUNCT O

Here ADV O
we PRON O
sought VERB O
to PART O
validate VERB O
the DET O
glycoforms NOUN O
as ADP O
a DET O
biomarker NOUN O
of ADP O
mucinous ADJ O
cysts NOUN O
and CCONJ O
to PART O
specify VERB O
the DET O
oligosaccharide NOUN O
linkages NOUN O
that SCONJ O
characterize VERB O
MUC5AC PROPN O
. PUNCT O
We PRON O
hypothesized VERB O
that SCONJ O
mucinous ADJ O
cysts NOUN O
secrete VERB O
MUC5AC PROPN O
displaying VERB O
terminal ADJ O
N NOUN B-LF
- NOUN I-LF
acetylglucosamine NOUN I-LF
( PUNCT O
GlcNAc PROPN B-AC
) PUNCT O
in ADP O
either CCONJ O
alpha NOUN O
or CCONJ O
beta NOUN O
linkage NOUN O
. PUNCT O

YACs NOUN B-AC
were AUX O
retrofitted VERB O
into ADP O
bacterial ADJ B-LF
artificial ADJ I-LF
chromosomes NOUN I-LF
( PUNCT O
BACs PROPN B-AC
) PUNCT O
by ADP O
homologous ADJ O
recombination NOUN O
in ADP O
yeast NOUN O
using VERB O
a DET O
BAC PROPN B-AC
/ SYM O
NeoR PROPN O
retrofitting VERB O
vector NOUN O
, PUNCT O
BRV1 PROPN O
, PUNCT O
and CCONJ O
then ADV O
transformed VERB O
into ADP O
a DET O
recA PROPN O
DH10B PROPN O
E. PROPN O
coli PROPN O
strain NOUN O
( PUNCT O
Kouprina PROPN O
and CCONJ O
Larionov PROPN O
1999 NUM O
) PUNCT O
. PUNCT O

HFpEF PROPN B-AC
is AUX O
characterized VERB O
by ADP O
pulmonary ADJ O
edema NOUN O
, PUNCT O
left ADJ B-LF
ventricular ADJ I-LF
( PUNCT O
LV PROPN B-AC
) PUNCT O
diastolic ADJ O
impairment NOUN O
, PUNCT O
and CCONJ O
increased ADJ O
LV PROPN B-AC
filling NOUN O
pressures NOUN O
. PUNCT O

BMDM PROPN B-AC
, PUNCT O
bone NOUN B-LF
marrow NOUN I-LF
– PUNCT I-LF
derived VERB I-LF
MΦ PROPN I-LF
; PUNCT O
HS PROPN B-AC
, PUNCT O
high ADJ B-LF
salt NOUN I-LF
; PUNCT O
MΦ PROPN B-AC
, PUNCT O
monocyte NOUN B-LF
/ SYM I-LF
macrophage NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
cell NOUN I-LF
; PUNCT O
NCX PROPN B-AC
, PUNCT O
Na+/Ca2 NOUN B-LF
+ NUM I-LF
exchanger NOUN I-LF
; PUNCT O
ns NOUN B-AC
, PUNCT O
nonsilencing NOUN B-LF
; PUNCT O
siRNA NOUN B-AC
, PUNCT O
small ADJ B-LF
interfering VERB I-LF
RNA NOUN I-LF
; PUNCT O
Slc8 NOUN O
, PUNCT O
solute NOUN O
carrier NOUN O
family NOUN O
8 NUM O
; PUNCT O
VR NOUN O
, PUNCT O
voltage NOUN O
ramp NOUN O
. PUNCT O

For ADP O
example NOUN O
, PUNCT O
growth NOUN O
factor NOUN O
stimulation NOUN O
activates VERB O
mTORC1 NOUN B-AC
via ADP O
the DET O
GTPase PROPN B-AC
Rheb PROPN O
, PUNCT O
whereas SCONJ O
amino ADJ O
acids NOUN O
activate VERB O
mTORC1 NOUN B-AC
through ADP O
the DET O
heterodimeric ADJ O
Rag PROPN O
, PUNCT O
adenosine ADJ B-LF
diphosphate NOUN I-LF
ribosylation NOUN I-LF
factor-1 NOUN I-LF
( PUNCT O
Arf1 PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
Rab1 PROPN O
GTPases PROPN B-AC
[ X O
8–11 NUM O
] PUNCT O
. PUNCT O

Testicular ADJ B-LF
germ NOUN I-LF
cell NOUN I-LF
tumor NOUN I-LF
( PUNCT O
TGCT PROPN B-AC
) PUNCT O
patients NOUN O
and CCONJ O
survivors NOUN O
have VERB O
excess ADJ O
mortality NOUN O
compared VERB O
to ADP O
the DET O
general ADJ O
male ADJ O
population NOUN O
, PUNCT O
but CCONJ O
relative ADJ B-LF
survival NOUN I-LF
( PUNCT O
RS NOUN B-AC
) PUNCT O
has AUX O
been AUX O
scarcely ADV O
studied VERB O
. PUNCT O

EGFP PROPN B-AC
, PUNCT O
enhanced ADJ B-LF
green ADJ I-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
Epac PROPN O
, PUNCT O
exchange NOUN O
protein NOUN O
directly ADV O
activated VERB O
by ADP O
cAMP NOUN B-AC
; PUNCT O
GAPDH PROPN B-AC
, PUNCT O
glyceraldehyde NOUN B-LF
3 NUM I-LF
- PUNCT I-LF
phosphate NOUN I-LF
dehydrogenase NOUN I-LF
; PUNCT O
HA3 PROPN B-AC
, PUNCT O
triple ADJ B-LF
hemagglutinin NOUN I-LF
; PUNCT O
IFA PROPN B-AC
, PUNCT O
immunofluorescence NOUN B-LF
assay NOUN I-LF
; PUNCT O
PKAc PROPN B-AC
, PUNCT O
catalytic ADJ B-LF
subunit NOUN I-LF
of ADP I-LF
cAMP NOUN I-LF
- PUNCT I-LF
dependent ADJ I-LF
protein NOUN I-LF
kinase NOUN I-LF
; PUNCT O
PMV PROPN O
, PUNCT O
plasmepsin NOUN O
V NOUN O
; PUNCT O
RAP PROPN B-AC
, PUNCT O
rapamycin NOUN B-LF
. PUNCT O

* PUNCT O
* PUNCT O
PCa NOUN B-AC
: PUNCT O
Prostate NOUN B-LF
cancer NOUN I-LF
. PUNCT O

A. X O
The DET O
network NOUN O
’s PART O
strongly ADV B-LF
connected VERB I-LF
component NOUN I-LF
( PUNCT O
SCC PROPN B-AC
) PUNCT O
comprises VERB O
almost ADV O
half NOUN O
of ADP O
the DET O
nodes NOUN O
and CCONJ O
more ADJ O
than ADP O
two NUM O
- PUNCT O
thirds NOUN O
of ADP O
the DET O
edges NOUN O
; PUNCT O
it PRON O
contains VERB O
both CCONJ O
positive ADJ O
and CCONJ O
negative ADJ O
feedback NOUN O
loops NOUN O
. PUNCT O

The DET O
Pan PROPN B-LF
American PROPN I-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT O
PAHO PROPN B-AC
) PUNCT O
and CCONJ O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT O
WHO PROPN B-AC
) PUNCT O
published VERB O
an DET O
alert NOUN O
about ADP O
a DET O
possible ADJ O
association NOUN O
with ADP O
increases NOUN O
in ADP O
reports NOUN O
of ADP O
congenital ADJ O
abnormalities NOUN O
and CCONJ O
Guillain PROPN B-LF
– PUNCT I-LF
Barré PROPN I-LF
syndrome NOUN I-LF
( PUNCT O
GBS PROPN B-AC
) PUNCT O
on ADP O
December PROPN O
1 NUM O
, PUNCT O
2015 NUM O
[ PUNCT O
2 NUM O
] PUNCT O
. PUNCT O

SOFA PROPN B-AC
: PUNCT O
sequential ADJ B-LF
organ NOUN I-LF
failure NOUN I-LF
assessment NOUN I-LF
, PUNCT O
SAPS PROPN B-AC
II NUM B-AC
: PUNCT O
simplified ADJ O
acute ADJ O
physiologic ADJ O
score NOUN O
, PUNCT O
ISS PROPN B-AC
: PUNCT O
injury NOUN B-LF
severity NOUN I-LF
score NOUN I-LF
, PUNCT O
AIS PROPN B-AC
: PUNCT O
abbreviated ADJ B-LF
injury NOUN I-LF
scale NOUN I-LF
, PUNCT O
SAP PROPN B-AC
: PUNCT O
systolic ADJ B-LF
arterial ADJ I-LF
blood NOUN I-LF
pressure NOUN I-LF
, PUNCT O
ICU PROPN B-AC
: PUNCT O
intensive ADJ B-LF
care NOUN I-LF
unit NOUN I-LF
, PUNCT O
LOS PROPN B-AC
: PUNCT O
length NOUN B-LF
of ADP I-LF
stay NOUN I-LF
. PUNCT O

CNO PROPN B-AC
, PUNCT O
clozapine NOUN B-LF
- PUNCT I-LF
n CCONJ I-LF
- PUNCT I-LF
oxide NOUN I-LF
; PUNCT O
LH PROPN B-AC
, PUNCT O
lateral ADJ B-LF
hypothalamic ADJ I-LF
area NOUN I-LF
; PUNCT O
Nts PROPN B-AC
, PUNCT O
neurotensin NOUN B-LF
. PUNCT O

* PUNCT O
HF PROPN B-AC
= PUNCT O
Health PROPN B-LF
Facility PROPN I-LF
. PUNCT O

GABA NOUN B-AC
, PUNCT O
γ NOUN B-LF
- PUNCT I-LF
aminobutyric ADJ I-LF
acid NOUN I-LF
; PUNCT O
gad NOUN B-AC
, PUNCT O
glutamate NOUN B-LF
decarboxylase NOUN I-LF
enzyme NOUN I-LF
gene NOUN I-LF
. PUNCT O

Streck NOUN O
= PUNCT O
cfDNA NOUN B-AC
Urine NOUN O
Preserve PROPN O
, PUNCT O
UCM PROPN B-AC
= PUNCT O
Urine NOUN B-LF
conservation NOUN I-LF
medium NOUN I-LF
. PUNCT O

These DET O
small ADJ O
regulatory ADJ O
RNAs NOUN O
are AUX O
mainly ADV O
of ADP O
two NUM O
types NOUN O
; PUNCT O
microRNAs NOUN B-LF
( PUNCT O
miRNAs NOUN B-AC
) PUNCT O
and CCONJ O
short ADJ B-LF
interfering VERB I-LF
RNAs NOUN I-LF
( PUNCT O
siRNAs NOUN B-AC
) PUNCT O
, PUNCT O
both PRON O
of ADP O
which PRON O
consist VERB O
of ADP O
21–24 NUM O
nucleotide NOUN O
and CCONJ O
are AUX O
generated VERB O
from ADP O
the DET O
synthesis NOUN O
processes NOUN O
of ADP O
double ADJ B-LF
- PUNCT I-LF
stranded ADJ I-LF
RNAs NOUN I-LF
( PUNCT O
dsRNA NOUN B-AC
) PUNCT O
[ PUNCT O
1,2 NUM O
] PUNCT O
. PUNCT O

Local ADJ O
values NOUN O
of ADP O
spatiotemporal ADJ O
contrast NOUN O
ranged VERB O
from ADP O
6 NUM O
% NOUN O
to ADP O
50 NUM O
% NOUN O
root NOUN B-LF
- PUNCT I-LF
mean NOUN I-LF
- PUNCT I-LF
squared VERB I-LF
( PUNCT O
RMS PROPN B-AC
) PUNCT O
contrast NOUN O
( PUNCT O
see VERB O
Methods NOUN O
) PUNCT O
. PUNCT O

BC NOUN B-AC
= PUNCT O
breast NOUN B-LF
cancer NOUN I-LF
symptom NOUN O
; PUNCT O
GP NOUN O
= PUNCT O
general ADJ O
population NOUN O

NC PROPN O
: PUNCT O
Normal ADJ O
control NOUN O
; PUNCT O
EG PROPN B-AC
: PUNCT O
Ethylene NOUN B-LF
glycol NOUN I-LF
; PUNCT O
CYS PROPN B-AC
: PUNCT O
Cystone PROPN B-LF
; PUNCT O
STS PROPN B-AC
: PUNCT O
Sodium NOUN B-LF
thiosulfate NOUN I-LF
; PUNCT O
CAND NOUN B-AC
: PUNCT O
Candesartan PROPN B-LF
. PUNCT O

LFP NOUN B-AC
, PUNCT O
local ADJ B-LF
field NOUN I-LF
potential NOUN I-LF
; PUNCT O
MG NOUN B-AC
, PUNCT O
mid ADJ B-LF
- ADJ I-LF
frequency ADJ I-LF
gamma NOUN I-LF
; PUNCT O
SG NOUN B-AC
, PUNCT O
slow ADJ B-LF
gamma NOUN I-LF
. PUNCT O

AUC PROPN B-AC
, PUNCT O
area NOUN B-LF
under ADP I-LF
the DET I-LF
receiver NOUN I-LF
operating NOUN I-LF
characteristics NOUN I-LF
curve NOUN I-LF
; PUNCT O
CI NOUN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
XGBoost PROPN B-AC
, PUNCT O
extreme ADJ B-LF
gradient NOUN I-LF
boost NOUN I-LF
. PUNCT O

Corn NOUN O
soy NOUN O
blend NOUN O
with ADP O
extra ADJ O
micronutrients NOUN O
( PUNCT O
CSB PROPN O
) PUNCT O
is AUX O
a DET O
widely ADV O
- PUNCT O
applied VERB O
ready ADJ B-LF
- PUNCT I-LF
to PART I-LF
- PUNCT I-LF
use VERB I-LF
supplementary ADJ I-LF
food NOUN I-LF
( PUNCT O
RUSF PROPN B-AC
) PUNCT O
to PART O
treat VERB O
malnourished ADJ O
children NOUN O
. PUNCT O

IMD PROPN B-AC
, PUNCT O
Index PROPN B-LF
of ADP I-LF
Multiple PROPN I-LF
Deprivation PROPN I-LF
. PUNCT O

M NOUN O
: PUNCT O
males NOUN O
; PUNCT O
F NOUN O
: PUNCT O
females NOUN O
; PUNCT O
P NOUN O
- NOUN O
S NOUN O
: PUNCT O
phase NOUN O
- NOUN O
sensitive ADJ O
device NOUN O
; PUNCT O
BIA NOUN B-AC
: PUNCT O
bioelectrical ADJ B-LF
impedance NOUN I-LF
analysis NOUN I-LF
; PUNCT O
BIVA NOUN B-AC
: PUNCT O
bioelectrical ADJ B-LF
impedance NOUN I-LF
vector NOUN I-LF
analysis NOUN I-LF
; PUNCT O
DXA NOUN B-AC
: PUNCT O
dual ADJ B-LF
- NOUN I-LF
energy NOUN I-LF
X NOUN I-LF
- NOUN I-LF
ray NOUN I-LF
absorptiometry NOUN I-LF
; PUNCT O
R NOUN O
: PUNCT O
resistance NOUN O
; PUNCT O
Xc NOUN B-AC
: PUNCT O
reactance NOUN O
; PUNCT O
PA NOUN B-AC
: PUNCT O
phase NOUN B-LF
angle NOUN I-LF
; PUNCT O
h NOUN O
: PUNCT O
height NOUN O
; PUNCT O
BM NOUN B-AC
: PUNCT O
body NOUN B-LF
mass NOUN I-LF
; PUNCT O
RPE NOUN O
: PUNCT O
rating NOUN O
of ADP O
perceived VERB O
exertion NOUN O
; PUNCT O
BMI PROPN B-AC
: PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF

To PART O
obtain VERB O
the DET O
most ADV O
robust ADJ O
prediction NOUN O
of ADP O
QTLs NOUN B-AC
, PUNCT O
several ADJ O
mapping NOUN O
methods NOUN O
were AUX O
applied VERB O
to PART O
search VERB O
for ADP O
QTLs NOUN B-AC
, PUNCT O
including VERB O
single ADJ O
marker NOUN O
analysis NOUN O
[ PUNCT O
36 NUM O
] PUNCT O
, PUNCT O
interval NOUN B-LF
mapping NOUN I-LF
( PUNCT O
IM PROPN B-AC
) PUNCT O
[ PUNCT O
37 NUM O
] PUNCT O
, PUNCT O
composite ADJ B-LF
interval NOUN I-LF
mapping NOUN I-LF
( PUNCT O
CIM PROPN B-AC
) PUNCT O
[ PUNCT O
38,39 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
multiple ADJ B-LF
interval NOUN I-LF
mapping NOUN I-LF
( PUNCT O
MIM PROPN B-AC
) PUNCT O
[ PUNCT O
40 NUM O
] PUNCT O
. PUNCT O

This DET O
regimen NOUN O
was AUX O
intended VERB O
to PART O
mimic VERB O
the DET O
in ADP O
vivo ADJ O
behavioral ADJ O
experiments NOUN O
, PUNCT O
in ADP O
which PRON O
spatial ADJ O
learning NOUN O
is AUX O
tested VERB O
long ADV O
after SCONJ O
FGL PROPN B-AC
has AUX O
been AUX O
cleared VERB O
from ADP O
cerebrospinal ADJ B-LF
fluid NOUN I-LF
( PUNCT O
CSF PROPN B-AC
) PUNCT O
[ PUNCT O
13 NUM O
] PUNCT O
. PUNCT O

We PRON O
began VERB O
by ADP O
cloning VERB O
the DET O
CD4 NOUN O
genes NOUN O
of ADP O
15 NUM O
primate ADJ O
species NOUN O
, PUNCT O
plus CCONJ O
human ADJ O
CD4 NOUN O
. PUNCT O
Using VERB O
retroviral ADJ O
transduction NOUN O
, PUNCT O
we PRON O
stably ADV O
introduced VERB O
these DET O
genes NOUN O
into ADP O
Cf2Th NOUN O
cells NOUN O
( PUNCT O
dog NOUN O
thymocytes NOUN O
) PUNCT O
that PRON O
had AUX O
also ADV O
been AUX O
engineered VERB O
to PART O
express VERB O
the DET O
human ADJ O
C PROPN B-LF
- PUNCT I-LF
C PROPN I-LF
motif NOUN I-LF
chemokine NOUN I-LF
receptor NOUN I-LF
5 NUM I-LF
( PUNCT O
CCR5 PROPN B-AC
) PUNCT O
coreceptor NOUN O
for ADP O
HIV-1 PROPN O
entry NOUN O
( PUNCT O
S1 PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

SCO PROPN B-LF
- ADJ I-LF
spondin ADJ I-LF
- ADJ I-LF
like ADJ I-LF

Underlying ADJ O
data NOUN O
can AUX O
be AUX O
found VERB O
in ADP O
S1 PROPN O
Data PROPN O
. PUNCT O
hpf PROPN B-AC
, PUNCT O
hours NOUN B-LF
post ADP I-LF
fertilization NOUN I-LF
; PUNCT O
KD PROPN B-AC
, PUNCT O
knock NOUN B-LF
- PUNCT I-LF
down NOUN I-LF
; PUNCT O
n.s PROPN O
. PUNCT O
, PUNCT O
not PART O
significant ADJ O
; PUNCT O
PhR PROPN B-AC
, PUNCT O
photoreceptor NOUN B-LF
; PUNCT O
WT PROPN O
, PUNCT O
wild ADJ O
type NOUN O
. PUNCT O

SA NOUN B-AC
: PUNCT O
suture NOUN B-LF
anchor NOUN I-LF
, PUNCT O
TS NOUN B-AC
: PUNCT O
transosseous ADJ B-LF
suture NOUN I-LF
, PUNCT O
BMI NOUN B-AC
: PUNCT O
body NOUN O
- PUNCT O
mass NOUN O
index NOUN O

Proopiomelanocortin NOUN B-LF
( PUNCT O
POMC PROPN B-AC
) PUNCT O
and CCONJ O
proenkephalin NOUN B-LF
( PUNCT O
PENK PROPN B-AC
) PUNCT O
, PUNCT O
the DET O
precursors NOUN O
of ADP O
the DET O
endogenous ADJ O
peptide NOUN O
ligands NOUN O
endorphins NOUN O
and CCONJ O
enkephalins NOUN O
, PUNCT O
have AUX O
been AUX O
detected VERB O
in ADP O
human ADJ O
skin NOUN O
[ PUNCT O
7 NUM O
, PUNCT O
9–15 NUM O
] PUNCT O
. PUNCT O

† PUNCT O
C.I. PROPN O
, PUNCT O
confidence NOUN O
interval NOUN O
; PUNCT O
HU PROPN O
, PUNCT O
Hounsfield PROPN O
unit NOUN O
; PUNCT O
HUHA PROPN B-AC
, PUNCT O
Hounsfield PROPN B-LF
unit NOUN I-LF
histogram NOUN I-LF
analysis NOUN I-LF
; PUNCT O
SD NOUN O
, PUNCT O
standard ADJ O
deviation NOUN O
. PUNCT O

The PRON O
curve NOUN O
line NOUN O
represents VERB O
alkali NOUN B-LF
- PUNCT I-LF
salt NOUN I-LF
tolerance NOUN I-LF
trait NOUN I-LF
index NOUN I-LF
( PUNCT O
ASTTI NOUN B-AC
) PUNCT O
. PUNCT O
The PRON O
greater ADJ O
the DET O
ASTTI NOUN B-AC
, PUNCT O
the DET O
better ADJ O
the DET O
alkali NOUN O
salt NOUN O
tolerance NOUN O
. PUNCT O

CI PROPN O
, PUNCT O
confidence NOUN O
interval NOUN O
; PUNCT O
OR PROPN B-AC
, PUNCT O
odds NOUN B-LF
ratio NOUN I-LF
; PUNCT O
W NOUN O
, PUNCT O
weight NOUN O
. PUNCT O

Bulimia PROPN B-LF
nervosa NOUN I-LF
( PUNCT O
BN PROPN B-AC
) PUNCT O
describes VERB O
recurring VERB O
episodes NOUN O
of ADP O
binge NOUN O
eating NOUN O
and CCONJ O
inappropriate ADJ O
compensatory ADJ O
behaviour NOUN O
to PART O
prevent VERB O
weight NOUN O
gain NOUN O
. PUNCT O

Three NUM O
polyproline NOUN B-LF
II NUM I-LF
helix NOUN O
regions NOUN O
— PUNCT O
P13 NOUN O
– SYM O
P16 NOUN O
( PUNCT O
PPII-1 NOUN B-AC
) PUNCT O
, PUNCT O
P19 PROPN O
– SYM O
P22 NOUN O
( PUNCT O
PPII-2 NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
P28 PROPN O
– SYM O
P31 NOUN O
( PUNCT O
PPII-3 NOUN B-AC
) PUNCT O
— PUNCT O
are AUX O
labeled VERB O
. PUNCT O
( PUNCT O
C NOUN O
– SYM O
D NOUN O
) PUNCT O
Increase NOUN O
in ADP O
surface NOUN O
area NOUN O
in ADP O
larger ADJ O
PXX33 PROPN O
polypeptides NOUN O
( PUNCT O
C NOUN O
) PUNCT O
versus ADP O
PXX12 PROPN O
polypeptides NOUN O
( PUNCT O
D NOUN O
) PUNCT O
, PUNCT O
resulting VERB O
in ADP O
increased VERB O
interaction NOUN O
, PUNCT O
van PROPN O
der PROPN O
Waals PROPN O
attraction NOUN O
, PUNCT O
and CCONJ O
denser ADJ O
aggregates NOUN O
. PUNCT O

The DET O
recorded VERB O
comorbidities NOUN O
were AUX O
hypertension NOUN B-LF
( PUNCT O
HT PROPN B-AC
) PUNCT O
, PUNCT O
diabetes NOUN B-LF
mellitus NOUN I-LF
( PUNCT O
DM PROPN B-AC
) PUNCT O
, PUNCT O
chronic ADJ B-LF
obstructive ADJ I-LF
pulmonary ADJ I-LF
disease NOUN I-LF
( PUNCT O
COPD PROPN B-AC
) PUNCT O
, PUNCT O
stroke NOUN O
, PUNCT O
cirrhosis NOUN O
, PUNCT O
and CCONJ O
end NOUN B-LF
- PUNCT I-LF
stage NOUN I-LF
renal ADJ I-LF
disease NOUN I-LF
( PUNCT O
ESRD PROPN B-AC
) PUNCT O
. PUNCT O
Specifically ADV O
, PUNCT O
ESRD PROPN B-AC
was AUX O
defined VERB O
as ADP O
estimated VERB O
GFR NOUN O
< ADP O
15 NUM O
mL NOUN O
/ SYM O
min/1.73m2 NUM O
with ADP O
long ADJ O
- PUNCT O
term NOUN O
dialysis NOUN O
therapy NOUN O
. PUNCT O

topoisomerase NOUN B-LF
I NOUN I-LF
- PUNCT I-LF
activated VERB I-LF
pCR2.1 NOUN I-LF
- PUNCT I-LF
TOPO NOUN I-LF
vector NOUN I-LF

Primary ADJ O
outcome NOUN O
was AUX O
post ADJ B-LF
- PUNCT I-LF
traumatic ADJ I-LF
stress NOUN I-LF
disorder NOUN I-LF
( PUNCT O
PTSD PROPN B-AC
) PUNCT O
symptoms NOUN O
or CCONJ O
caseness NOUN O
, PUNCT O
and CCONJ O
secondary ADJ O
outcomes NOUN O
were AUX O
depression NOUN O
symptoms NOUN O
, PUNCT O
functioning NOUN O
, PUNCT O
quality NOUN O
of ADP O
life NOUN O
, PUNCT O
and CCONJ O
adverse ADJ O
effects NOUN O
, PUNCT O
after ADP O
treatment NOUN O
and CCONJ O
at ADV O
follow NOUN O
- PUNCT O
up NOUN O
of ADP O
at ADV O
least ADV O
3 NUM O
months NOUN O
. PUNCT O

Combinations NOUN O
of ADP O
PA PROPN B-AC
plus CCONJ O
EF PROPN B-AC
or CCONJ O
LF PROPN B-AC
are AUX O
respectively ADV O
referred VERB O
to ADP O
as ADP O
edema NOUN O
toxin NOUN O
or CCONJ O
lethal ADJ B-LF
toxin NOUN I-LF
( PUNCT O
LeTx PROPN B-AC
) PUNCT O
[ PUNCT O
13 NUM O
] PUNCT O
. PUNCT O

CTX PROPN B-AC
- PUNCT B-AC
I NUM B-AC
, PUNCT O
carboxy ADJ B-LF
- PUNCT I-LF
terminal ADJ I-LF
telopeptide NOUN I-LF
of ADP I-LF
type NOUN I-LF
I NUM I-LF
collagen NOUN I-LF
; PUNCT O
ELISA PROPN O
, PUNCT O
enzyme NOUN O
linked VERB O
immunosorbent NOUN O
assay NOUN O
; PUNCT O
M PROPN B-AC
- PUNCT B-AC
CSF PROPN B-AC
, PUNCT O
macrophage NOUN B-LF
colony NOUN I-LF
- PUNCT I-LF
stimulating VERB I-LF
factor NOUN I-LF
; PUNCT O
OVX PROPN B-AC
, PUNCT O
ovariectomy NOUN B-LF
- PUNCT O
induced VERB O
bone NOUN O
loss NOUN O
; PUNCT O
PBS PROPN B-AC
, PUNCT O
phosphate NOUN B-LF
- PUNCT I-LF
buffered VERB I-LF
saline NOUN I-LF
; PUNCT O
RGD PROPN B-AC
, PUNCT O
Arginine PROPN B-LF
- PUNCT I-LF
Glycine PROPN I-LF
- PUNCT I-LF
Aspartic NOUN I-LF
acid NOUN I-LF
; PUNCT O
s.c X O
. PUNCT O
, PUNCT O
subcutaneously ADV O
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
type NOUN I-LF
. PUNCT O

Loss NOUN O
of ADP O
BBS PROPN B-AC
proteins NOUN O
affects VERB O
the DET O
entry NOUN O
and CCONJ O
exit NOUN O
of ADP O
signalling VERB O
receptors NOUN O
such ADJ O
as ADP O
somatostatin NOUN B-LF
receptor NOUN I-LF
type NOUN I-LF
3 NUM I-LF
( PUNCT O
Sstr3 NOUN B-AC
) PUNCT O
, PUNCT O
melanin NOUN B-LF
- PUNCT I-LF
concentrating VERB I-LF
hormone NOUN I-LF
receptor NOUN I-LF
1 NUM I-LF
( PUNCT O
Mchr1 NOUN B-AC
) PUNCT O
, PUNCT O
dopamine NOUN B-LF
receptors NOUN I-LF
( PUNCT O
D1 NOUN B-AC
) PUNCT O
, PUNCT O
G NOUN B-LF
- PUNCT I-LF
protein NOUN I-LF
coupled VERB I-LF
receptor NOUN I-LF
161 NUM I-LF
( PUNCT O
Gpr161 NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
brain NOUN B-LF
- PUNCT I-LF
derived VERB I-LF
neurotrophic ADJ I-LF
factor NOUN I-LF
( PUNCT O
BDNF PROPN B-AC
) PUNCT O
receptors NOUN O
( PUNCT O
TrkB PROPN B-AC
) PUNCT O
[ PUNCT O
14,15 NUM O
] PUNCT O
. PUNCT O

This DET O
study NOUN O
was AUX O
reported VERB O
in ADP O
accordance NOUN O
with ADP O
the DET O
REporting NOUN B-LF
of ADP I-LF
studies NOUN I-LF
Conducted VERB I-LF
using VERB I-LF
Observational ADJ I-LF
Routinely ADV I-LF
collected VERB I-LF
health NOUN I-LF
Data NOUN I-LF
( PUNCT O
RECORD NOUN B-AC
) PUNCT O
statement NOUN O
( PUNCT O
see VERB O
S1 PROPN O
Checklist NOUN O
) PUNCT O
. PUNCT O

We PRON O
further ADV O
showed VERB O
that SCONJ O
the DET O
eye NOUN B-LF
- PUNCT I-LF
enriched VERB I-LF
kainate NOUN I-LF
receptor NOUN I-LF
( PUNCT O
EKAR PROPN B-AC
) PUNCT O
receives VERB O
the DET O
retrograde ADJ O
glutamate NOUN O
signal NOUN O
in ADP O
photoreceptor NOUN O
terminals NOUN O
. PUNCT O

We PRON O
then ADV O
verified VERB O
each DET O
candidate NOUN O
by ADP O
using VERB O
Integrative PROPN B-LF
Genomics PROPN I-LF
Viewer PROPN I-LF
( PUNCT O
IGV PROPN B-AC
, PUNCT O
[ X O
38–40 NUM O
] PUNCT O
) PUNCT O
. PUNCT O

Cotrimoxazole NOUN B-LF
( PUNCT O
CTX PROPN B-AC
) PUNCT O
prophylaxis NOUN O
is AUX O
recommended VERB O
by ADP O
the DET O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT O
WHO PROPN B-AC
) PUNCT O
for ADP O
HIV-1 NUM B-AC
- PUNCT O
infected VERB O
individuals NOUN O
in ADP O
settings NOUN O
with ADP O
high ADJ O
infectious ADJ O
disease NOUN O
prevalence NOUN O
. PUNCT O

Scaffold NOUN B-LF
/ SYM I-LF
matrix NOUN I-LF
attachment NOUN I-LF
regions NOUN I-LF
( PUNCT O
S PROPN B-AC
/ SYM B-AC
MARs PROPN O
) PUNCT O
are AUX O
AT NOUN O
- PUNCT O
rich ADJ O
DNA NOUN O
sequences NOUN O
that PRON O
mediate VERB O
structural ADJ O
organization NOUN O
of ADP O
the DET O
chromatin NOUN O
within ADP O
the DET O
nucleus NOUN O
. PUNCT O

To PART O
further ADV O
characterize VERB O
the DET O
interaction NOUN O
of ADP O
PAL PROPN B-AC
- PUNCT O
CRID3 PROPN O
with ADP O
components NOUN O
of ADP O
the DET O
NLRP3 PROPN B-AC
inflammasome NOUN O
, PUNCT O
we PRON O
assessed VERB O
binding VERB O
to ADP O
human ADJ O
never ADV B-LF
- PUNCT I-LF
in ADP I-LF
- PUNCT I-LF
mitosis NOUN I-LF
- PUNCT I-LF
gene NOUN I-LF
- PUNCT I-LF
a NOUN I-LF
– PUNCT I-LF
related VERB I-LF
kinase NOUN I-LF
7 NUM I-LF
( PUNCT O
NEK7 PROPN B-AC
) PUNCT O
, PUNCT O
apoptosis NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
speck NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
protein NOUN I-LF
( PUNCT O
ASC PROPN B-AC
) PUNCT O
, PUNCT O
Casp1 PROPN B-AC
, PUNCT O
and CCONJ O
GSDMD PROPN B-AC
. PUNCT O
PAL PROPN B-AC
- PUNCT O
CRID3 PROPN O
failed VERB O
to ADP O
label VERB O
the DET O
NLRP3 PROPN B-AC
inflammasome NOUN O
components NOUN O
in ADP O
the DET O
panel NOUN O
apart ADV O
from ADP O
NLRP3 PROPN B-AC
( PUNCT O
Fig PROPN O
1F NUM O
) PUNCT O
. PUNCT O
Collectively ADV O
, PUNCT O
these DET O
results NOUN O
suggest VERB O
that SCONJ O
CRID PROPN B-AC
compounds NOUN O
, PUNCT O
including VERB O
MCC950 PROPN O
/ SYM O
CRID3 PROPN O
, PUNCT O
inhibit VERB O
NLRP3 PROPN B-AC
inflammasome NOUN O
signaling NOUN O
by ADP O
directly ADV O
binding VERB O
to ADP O
NLRP3 PROPN B-AC
. PUNCT O

We PRON O
examined VERB O
circulating VERB O
plasma NOUN O
LECT2 NOUN B-AC
levels NOUN O
in ADP O
the DET O
subjects NOUN O
with ADP O
non ADJ B-LF
- ADJ I-LF
alcoholic ADJ I-LF
fatty ADJ I-LF
liver NOUN I-LF
disease NOUN I-LF
( PUNCT O
NAFLD PROPN B-AC
) PUNCT O
or CCONJ O
metabolic ADJ O
syndrome NOUN O
. PUNCT O

The DET O
new ADJ O
model NOUN O
expands VERB O
the DET O
currently ADV O
prevailing ADJ O
diffusion NOUN O
magnetic ADJ B-LF
resonance NOUN I-LF
imaging NOUN I-LF
( PUNCT O
MRI PROPN B-AC
) PUNCT O
tractography NOUN O
approach NOUN O
by ADP O
incorporation NOUN O
of ADP O
additional ADJ O
features NOUN O
of ADP O
cortical ADJ O
microstructure NOUN O
and CCONJ O
cortico ADJ O
– ADJ O
cortical ADJ O
proximity NOUN O
. PUNCT O

BPS PROPN B-AC
, PUNCT O
biosurfactant ADJ B-LF
polysaccharide NOUN I-LF
; PUNCT O
BYK PROPN B-AC
, PUNCT O
bacterial ADJ B-LF
tyrosine NOUN I-LF
autokinase NOUN I-LF
; PUNCT O
EPS PROPN B-AC
, PUNCT O
exopolysaccharide NOUN B-LF
; PUNCT O
IM PROPN B-AC
, PUNCT O
inner ADJ B-LF
membrane NOUN I-LF
; PUNCT O
MASC PROPN B-AC
, PUNCT O
major ADJ B-LF
spore NOUN I-LF
coat NOUN I-LF
; PUNCT O
OM PROPN B-AC
, PUNCT O
outer ADJ B-LF
membrane NOUN I-LF
. PUNCT O

Thematic ADJ O
analysis NOUN O
was AUX O
applied VERB O
, PUNCT O
and CCONJ O
key ADJ O
themes NOUN O
were AUX O
developed VERB O
based VERB O
on ADP O
Kolb PROPN O
’s PART O
ELT PROPN B-AC
( PUNCT O
Experiential ADJ B-LF
learning NOUN I-LF
theory NOUN I-LF
) PUNCT O
. PUNCT O

GGOH PROPN B-AC
, PUNCT O
geranylgeraniol NOUN B-LF
; PUNCT O
IDC PROPN B-AC
, PUNCT O
intraerythrocytic ADJ B-LF
developmental ADJ I-LF
cycle NOUN I-LF
; PUNCT O
IPP PROPN B-AC
, PUNCT O
isopentenyl NOUN B-LF
pyrophosphate NOUN I-LF
; PUNCT O
ns NOUN O
, PUNCT O
not PART O
significant ADJ O
. PUNCT O

Parameter NOUN B-LF
profile NOUN I-LF
index NOUN I-LF
( PUNCT O
IPP PROPN B-AC
) PUNCT O

Rumah PROPN B-LF
- PUNCT I-LF
Sakit PROPN I-LF
- PUNCT I-LF
Umum PROPN I-LF
- PUNCT I-LF
Daerah PROPN I-LF
( PUNCT O
RSUD PROPN B-AC
) PUNCT O
is AUX O
the DET O
major ADJ O
regional ADJ O
hospital NOUN O
in ADP O
the DET O
Mimika PROPN O
District PROPN O
of ADP O
Papua PROPN O
, PUNCT O
Indonesia PROPN O
. PUNCT O

The DET O
classical ADJ O
parameters NOUN O
of ADP O
HRV NOUN B-AC
, PUNCT O
the DET O
frequency NOUN O
parameters NOUN O
of ADP O
the DET O
Low PROPN B-LF
Frequency PROPN I-LF
( PUNCT O
LF PROPN B-AC
) PUNCT O
and CCONJ O
High PROPN B-LF
Frequency PROPN I-LF
( PUNCT O
HF PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
their PRON O
normalized VERB O
values NOUN O
, PUNCT O
were AUX O
obtained VERB O
as ADV O
well ADV O
. PUNCT O

We PRON O
made VERB O
use NOUN O
of ADP O
the DET O
green ADJ B-LF
fluorescent NOUN I-LF
protein NOUN I-LF
( PUNCT O
GFP PROPN B-AC
) PUNCT O
transgenic ADJ O
line NOUN O
her5pac NOUN O
: NOUN O
egfp PROPN O
[ X O
24 NUM O
] PUNCT O
, PUNCT O
which PRON O
shows VERB O
a DET O
very ADV O
robust ADJ O
GFP PROPN B-AC
expression NOUN O
in ADP O
a DET O
V NOUN O
- ADJ O
shaped ADJ O
territory NOUN O
covering VERB O
the DET O
anlagen NOUN O
of ADP O
the DET O
midbrain NOUN O
and CCONJ O
rostral ADJ O
hindbrain NOUN O
at ADP O
bud NOUN O
stage NOUN O
. PUNCT O

In ADP O
Vancouver PROPN O
study NOUN O
center NOUN O
, PUNCT O
8 NUM O
% NOUN O
of ADP O
the DET O
subjects NOUN O
presented VERB O
with ADP O
hyperhidrosis NOUN B-LF
as SCONJ O
the DET O
primary ADJ O
concern NOUN O
, PUNCT O
as SCONJ O
compared VERB O
with ADP O
no DET O
such ADJ O
patients NOUN O
in ADP O
the DET O
Shanghai PROPN O
center NOUN O
( PUNCT O
Table NOUN O
1 NUM O
, PUNCT O
p NOUN O
= SYM O
2.5E-20 NUM O
) PUNCT O
, PUNCT O
indicating VERB O
there PRON O
is VERB O
a DET O
low ADJ O
level NOUN O
of ADP O
awareness NOUN O
of ADP O
HH PROPN B-AC
in ADP O
Shanghai PROPN O
. PUNCT O

HMD NOUN B-AC
- PUNCT O
Hyaline NOUN B-LF
membrane NOUN I-LF
disease NOUN I-LF
, PUNCT O
ANC NOUN B-AC
- PUNCT O
Antenatal ADJ B-LF
care NOUN I-LF
, PUNCT O
APH NOUN B-AC
- PUNCT O
Antepartum NOUN B-LF
Hemorrhage NOUN I-LF
, PUNCT O
COR NOUN O
- PUNCT O
Crude NOUN O
odd ADJ O
ratio NOUN O
, PUNCT O
AOR NOUN B-AC
- PUNCT O
Adjusted VERB B-LF
Odd ADJ I-LF
Ratio NOUN I-LF

N2RA NOUN B-AC
/ SYM O
RA NOUN O
; PUNCT O
N1+/RA NOUN B-AC
, PUNCT O
Notch1 PROPN B-LF
/ SYM O
Notch2 NOUN O
RA NOUN O
homozygous ADJ O
; PUNCT O
RA NOUN O
, PUNCT O
Arg PROPN O
( PUNCT O
N1R1974 NOUN O
/ SYM O
N2R1934 PROPN O
) PUNCT O
to ADP O
Ala PROPN O
substitution NOUN O
; PUNCT O
SMZL PROPN B-AC
, PUNCT O
splenic ADJ B-LF
marginal ADJ I-LF
zone NOUN I-LF
B PROPN I-LF
- PUNCT I-LF
cell NOUN I-LF
lymphoma NOUN I-LF
. PUNCT O

Sequence NOUN O
analysis NOUN O
of ADP O
random ADJ O
sheared VERB O
fragments NOUN O
[ PUNCT O
20 NUM O
] PUNCT O
, PUNCT O
BAC PROPN B-AC
( PUNCT O
bacterial ADJ B-LF
artificial ADJ I-LF
chromosome NOUN I-LF
) PUNCT O
end NOUN O
sequences NOUN O
( PUNCT O
BESs PROPN B-AC
) PUNCT O
[ PUNCT O
21 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
complete ADJ O
BAC PROPN B-AC
sequences NOUN O
from ADP O
100 NUM O
random ADJ O
regions NOUN O
[ PUNCT O
22 NUM O
] PUNCT O
showed VERB O
that SCONJ O
about ADV O
two NUM O
- PUNCT O
thirds NOUN O
of ADP O
the DET O
maize NOUN O
genome NOUN O
consists VERB O
of ADP O
transposable ADJ O
elements NOUN O
, PUNCT O
with ADP O
95 NUM O
% NOUN O
of ADP O
those PRON O
being AUX O
retrotransposons NOUN O
. PUNCT O

The DET O
first ADJ B-LF
dry ADJ I-LF
season NOUN I-LF
D1 PROPN B-AC
( PUNCT O
May PROPN O
2013 NUM O
– SYM O
October PROPN O
2013 NUM O
) PUNCT O
began VERB O
immediately ADV O
after ADP O
the DET O
releases NOUN O
, PUNCT O
followed VERB O
by ADP O
the DET O
first ADJ B-LF
wet ADJ I-LF
season NOUN I-LF
W1 PROPN B-AC
( PUNCT O
November PROPN O
2013 NUM O
– SYM O
April PROPN O
2014 NUM O
) PUNCT O
, PUNCT O
the DET O
second ADJ B-LF
dry ADJ I-LF
season NOUN I-LF
D2 PROPN B-AC
( PUNCT O
May PROPN O
2014 NUM O
– SYM O
Oct PROPN O
2014 NUM O
) PUNCT O
, PUNCT O
and CCONJ O
the DET O
second ADJ B-LF
wet ADJ I-LF
season NOUN I-LF
W2 PROPN B-AC
( PUNCT O
Nov PROPN O
2014 NUM O
– SYM O
Apr PROPN O
2015 NUM O
) PUNCT O
. PUNCT O

In ADP O
addition NOUN O
, PUNCT O
human ADJ O
functional ADJ B-LF
magnetic ADJ I-LF
resonance NOUN I-LF
imaging NOUN I-LF
( PUNCT O
fMRI NOUN B-AC
) PUNCT O
studies NOUN O
have AUX O
also ADV O
examined VERB O
whether SCONJ O
activity NOUN O
throughout ADP O
the DET O
brain NOUN O
reflects VERB O
reward NOUN O
PEs NOUN B-AC
[ PUNCT O
8–14 NUM O
] PUNCT O
. PUNCT O

We PRON O
undertook VERB O
a DET O
double ADJ O
- PUNCT O
blind ADJ O
randomised ADJ O
controlled ADJ O
trial NOUN O
of ADP O
small ADJ B-LF
- PUNCT I-LF
quantity NOUN I-LF
lipid NOUN I-LF
- PUNCT I-LF
based VERB I-LF
nutrient NOUN I-LF
supplements NOUN I-LF
( PUNCT O
SQ PROPN B-AC
- PUNCT B-AC
LNS PROPN B-AC
) PUNCT O
fortified VERB O
with ADP O
23 NUM O
micronutrients NOUN O
in ADP O
children NOUN O
aged ADJ O
6 NUM O
months NOUN B-LF
( PUNCT O
mo NOUN B-AC
) PUNCT O
to PART O
5 NUM O
years NOUN O
( PUNCT O
y NOUN O
) PUNCT O
presenting VERB O
with ADP O
an DET O
illness NOUN O
at ADP O
a DET O
rural ADJ O
primary ADJ O
healthcare NOUN O
centre NOUN O
in ADP O
The DET O
Gambia PROPN O
. PUNCT O

CHO PROPN B-AC
, PUNCT O
Chinese ADJ O
Hamster NOUN O
Ovary PROPN O
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
. PUNCT O

Screening NOUN O
was AUX O
performed VERB O
in ADP O
two NUM O
levels NOUN O
involving VERB O
two NUM O
reviewers NOUN O
( PUNCT O
NA NOUN O
and CCONJ O
LE PROPN O
) PUNCT O
, PUNCT O
working VERB O
independently ADV O
with ADP O
the DET O
established VERB O
eligibility NOUN O
criteria NOUN O
via ADP O
online ADJ O
systematic ADJ O
review NOUN O
software NOUN O
( PUNCT O
Distiller PROPN B-LF
Systematic PROPN I-LF
Review PROPN I-LF
( PUNCT O
DSR PROPN B-AC
) PUNCT O
Software PROPN O
; PUNCT O
Evidence PROPN O
Partners PROPN O
Inc PROPN O
, PUNCT O
Ottawa PROPN O
, PUNCT O
Canada PROPN O
) PUNCT O
. PUNCT O

An DET O
ontology NOUN O
helps VERB O
to PART O
clarify VERB O
a DET O
domain NOUN O
's PART O
semantics NOUN O
for ADP O
everyday ADJ O
use NOUN O
, PUNCT O
as SCONJ O
is AUX O
nicely ADV O
demonstrated VERB O
by ADP O
Gene PROPN B-LF
Ontology PROPN I-LF
( PUNCT O
GO PROPN B-AC
; PUNCT O
The DET O
Gene PROPN B-LF
Ontology PROPN I-LF
Consortium PROPN O
2000 NUM O
) PUNCT O
. PUNCT O

The DET O
carbohydrate NOUN O
composition NOUN O
of ADP O
the DET O
extracts NOUN O
was AUX O
analysed VERB O
using VERB O
polysaccharide NOUN B-LF
analysis NOUN I-LF
by ADP I-LF
carbohydrate NOUN I-LF
gel NOUN I-LF
electrophoresis NOUN I-LF
( PUNCT O
PACE PROPN B-AC
) PUNCT O
and CCONJ O
high ADJ O
- NOUN O
performance NOUN O
anion NOUN O
- NOUN O
exchange NOUN O
chromatography NOUN O
( PUNCT O
HPAEC PROPN O
) PUNCT O
. PUNCT O
Whether SCONJ O
there PRON O
were VERB O
any DET O
proteinaceous ADJ O
moieties NOUN O
linked VERB O
to ADP O
β NOUN O
- NOUN O
glucan NOUN O
was AUX O
also ADV O
examined VERB O
. PUNCT O

MC4R PROPN B-AC
, PUNCT O
melanocortin NOUN B-LF
4 NUM I-LF
receptor NOUN I-LF
gene NOUN O
; PUNCT O
PRSBMI PROPN B-AC
, PUNCT O
polygenic ADJ B-LF
risk NOUN I-LF
score NOUN I-LF
for ADP I-LF
BMI PROPN I-LF
. PUNCT O

OR CCONJ B-AC
, PUNCT O
odds NOUN B-LF
ratio NOUN I-LF
. PUNCT O

In ADP O
both CCONJ O
SEEG PROPN B-AC
( PUNCT O
Fig PROPN O
4A NUM O
and CCONJ O
4B NOUN O
) PUNCT O
and CCONJ O
MEG PROPN B-AC
( PUNCT O
Fig PROPN O
4C NUM O
and CCONJ O
4D NUM O
) PUNCT O
, PUNCT O
the DET O
connection NOUN O
density NOUN O
spectra NOUN O
revealed VERB O
an DET O
LF NOUN B-AC
α NOUN O
peak NOUN O
at ADP O
ratios NOUN O
1:2 NUM O
and CCONJ O
1:3 NUM O
, PUNCT O
which PRON O
indicates VERB O
significant ADJ O
CFS PROPN B-AC
coupling NOUN O
between ADP O
α NOUN O
with ADP O
β NOUN O
and CCONJ O
γ NOUN O
oscillations NOUN O
, PUNCT O
i.e. X O
, PUNCT O
α NOUN O
: NOUN O
β NOUN O
and CCONJ O
α NOUN O
: NOUN O
γ NOUN O
CFS PROPN B-AC
. PUNCT O
In ADP O
SEEG PROPN B-AC
, PUNCT O
the DET O
frequency NOUN O
range NOUN O
of ADP O
this DET O
peak NOUN O
was AUX O
approximately ADV O
6–12 NUM O
Hz NOUN O
and CCONJ O
in ADP O
MEG PROPN B-AC
, PUNCT O
7–15 NUM O
Hz NOUN O
. PUNCT O
This DET O
elevated ADJ O
amount NOUN O
of ADP O
significant ADJ O
interareal ADJ O
α NOUN O
: NOUN O
β NOUN O
and CCONJ O
α NOUN O
: NOUN O
γ NOUN O
CFS PROPN B-AC
was AUX O
also ADV O
reflected VERB O
as ADP O
a DET O
peak NOUN O
in ADP O
the DET O
corresponding ADJ O
graph NOUN B-LF
strength NOUN I-LF
( PUNCT O
GS PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
shows VERB O
that SCONJ O
these DET O
CFS PROPN B-AC
connections NOUN O
were AUX O
also ADV O
stronger ADJ O
in ADP O
terms NOUN O
of ADP O
the DET O
phase NOUN O
- PUNCT O
locking NOUN O
strength NOUN O
( PUNCT O
S3 PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

In ADP O
our PRON O
present ADJ O
study NOUN O
, PUNCT O
we PRON O
hypothesize VERB O
that SCONJ O
the DET O
protective ADJ O
role NOUN O
of ADP O
melatonin NOUN O
in ADP O
decreasing VERB O
M1 NOUN O
phenotype NOUN O
switching NOUN O
depends VERB O
on ADP O
uncoupling VERB B-LF
protein NOUN I-LF
2 NUM I-LF
( PUNCT O
UCP2 PROPN B-AC
) PUNCT O
pathway NOUN O
in ADP O
prorenin NOUN O
- PUNCT O
treated VERB O
microglia NOUN O
. PUNCT O

Persons NOUN O
with ADP O
both PRON O
CA- NOUN B-AC
and CCONJ O
HA PROPN B-AC
- PUNCT O
MRSA PROPN B-AC
in ADP O
repeated VERB O
samplings NOUN O
were AUX O
classified VERB O
as ADP O
having VERB O
a DET O
mixed VERB O
infection NOUN O
and CCONJ O
excluded VERB O
from ADP O
analyses NOUN O
of ADP O
CA- NOUN B-AC
and CCONJ O
HA PROPN B-AC
- PUNCT O
MRSA PROPN B-AC
but CCONJ O
included VERB O
in ADP O
the DET O
analysis NOUN O
of ADP O
all DET O
MRSA PROPN B-AC
. PUNCT O
Boundary ADJ O
data NOUN O
for ADP O
mapping VERB O
2011 NUM O
small ADJ O
geographies NOUN O
( PUNCT O
named VERB O
Lower PROPN B-LF
Layer PROPN I-LF
Super PROPN I-LF
Output PROPN I-LF
Areas PROPN I-LF
[ PUNCT O
LSOAs PROPN B-AC
] PUNCT O
) PUNCT O
in ADP O
catchment NOUN O
areas NOUN O
were AUX O
obtained VERB O
from ADP O
the DET O
Office PROPN O
for ADP O
National PROPN O
Statistics PROPN O
, PUNCT O
UK PROPN B-AC
[ PUNCT O
34 NUM O
] PUNCT O
. PUNCT O

As ADP O
a DET O
positive ADJ O
control NOUN O
, PUNCT O
we PRON O
examined VERB O
SMO PROPN O
colocalization NOUN O
with ADP O
nanobody NOUN B-LF
( PUNCT O
Nb NOUN B-AC
) PUNCT O
NbSmo2 NOUN O
, PUNCT O
which PRON O
binds VERB O
efficiently ADV O
and CCONJ O
specifically ADV O
to ADP O
the DET O
activated VERB O
conformation NOUN O
of ADP O
SMO PROPN O
( PUNCT O
Figs NOUN O
2A NOUN O
and CCONJ O
S2B PROPN O
and CCONJ O
S2C NOUN O
) PUNCT O
via ADP O
an DET O
intracellular ADJ O
epitope NOUN O
within ADP O
the DET O
seven NUM B-LF
- PUNCT I-LF
transmembrane NOUN I-LF
( PUNCT O
7TM NOUN B-AC
) PUNCT O
domain NOUN O
( PUNCT O
S2C NOUN O
– SYM O
S2E NOUN O
Fig PROPN O
) PUNCT O
. PUNCT O

CTNNB1 PROPN O
, PUNCT O
catenin NOUN O
beta-1 NOUN O
; PUNCT O
HCC PROPN B-AC
, PUNCT O
hepatocellular ADJ B-LF
carcinoma NOUN I-LF
; PUNCT O
IHC PROPN B-AC
, PUNCT O
immunoblotting NOUN O
analyses NOUN O
; PUNCT O
MT PROPN B-AC
, PUNCT O
mutant NOUN B-LF
; PUNCT O
PGM1 PROPN B-AC
, PUNCT O
phosphoglucomutase NOUN B-LF
1 NUM I-LF
; PUNCT O
TP53 PROPN O
, PUNCT O
Cellular ADJ O
tumor NOUN O
antigen NOUN O
p53 NOUN O
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

Other ADJ O
variables NOUN O
were AUX O
recorded VERB O
, PUNCT O
or CCONJ O
automatically ADV O
calculated VERB O
, PUNCT O
at ADP O
60 NUM O
- PUNCT O
sec NOUN O
intervals NOUN O
( PUNCT O
heart NOUN O
rate NOUN O
, PUNCT O
ETCO2 NOUN B-AC
, PUNCT O
central ADJ B-LF
venous ADJ I-LF
pressure NOUN I-LF
[ PUNCT O
CVP NOUN B-AC
] PUNCT O
, PUNCT O
systemic ADJ B-LF
vascular ADJ I-LF
resistance NOUN I-LF
[ PUNCT O
SVR PROPN B-AC
] PUNCT O
, PUNCT O
CO NOUN B-AC
, PUNCT O
stroke NOUN B-LF
volume NOUN I-LF
[ PUNCT O
SV NOUN B-AC
] PUNCT O
, PUNCT O
and CCONJ O
core NOUN O
temperature NOUN O
) PUNCT O
. PUNCT O

The DET O
AGT NOUN B-AC
– SYM O
Pex5p NOUN O
structure NOUN O
is AUX O
the DET O
second ADJ O
cargo NOUN O
protein NOUN O
– SYM O
Pex5p NOUN O
receptor NOUN O
complex NOUN O
determined VERB O
to ADP O
date NOUN O
, PUNCT O
the DET O
first ADJ O
being AUX O
sterol NOUN B-LF
carrier NOUN I-LF
protein NOUN I-LF
2 NUM I-LF
( PUNCT O
SCP2)–Pex5p NOUN B-AC
[ PUNCT O
15 NUM O
] PUNCT O
. PUNCT O

Members NOUN O
( PUNCT O
female ADJ O
and CCONJ O
male NOUN O
heads NOUN O
, PUNCT O
and CCONJ O
other ADJ O
married VERB O
male NOUN O
and CCONJ O
female ADJ O
in ADP O
the DET O
household NOUN O
) PUNCT O
from ADP O
all DET O
the DET O
three NUM O
categories NOUN O
of ADP O
households NOUN O
were AUX O
selected VERB O
purposefully ADV O
based VERB O
on ADP O
their PRON O
availability NOUN O
and CCONJ O
willingness NOUN O
to PART O
participate VERB O
in ADP O
individual ADJ O
in- PUNCT O
depth NOUN O
interviews NOUN O
( PUNCT O
IDIs NOUN B-AC
) PUNCT O
and CCONJ O
focus NOUN B-LF
group NOUN I-LF
discussions NOUN I-LF
( PUNCT O
FGDs NOUN B-AC
) PUNCT O
. PUNCT O

Because SCONJ O
the DET O
capacity NOUN O
to PART O
amplify VERB O
viral ADJ B-LF
RNA NOUN I-LF
( PUNCT O
vRNA NOUN B-AC
) PUNCT O
by ADP O
RT NOUN O
- PUNCT O
PCR NOUN O
from ADP O
the DET O
feces NOUN O
of ADP O
captive ADJ O
primates NOUN O
correlates VERB O
with ADP O
the DET O
amount NOUN O
of ADP O
virus NOUN O
in ADP O
plasma NOUN O
[ PUNCT O
61 NUM O
] PUNCT O
, PUNCT O
we PRON O
used VERB O
this PRON O
as ADP O
a DET O
proxy NOUN O
measure NOUN O
for ADP O
the DET O
systemic ADJ O
VL NOUN B-AC
of ADP O
wild ADJ O
chimpanzees NOUN O
( PUNCT O
see VERB O
Materials NOUN O
and CCONJ O
Methods NOUN O
for ADP O
more ADJ O
detail NOUN O
) PUNCT O
. PUNCT O

The DET O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT O
WHO PROPN B-AC
) PUNCT O
and CCONJ O
the DET O
United PROPN B-LF
Nations PROPN I-LF
Children PROPN I-LF
's PART I-LF
Fund PROPN I-LF
( PUNCT O
UNICEF PROPN B-AC
) PUNCT O
have AUX O
developed VERB O
a DET O
comprehensive ADJ O
strategy NOUN O
for ADP O
sustainable ADJ O
measles NOUN O
mortality NOUN O
reduction NOUN O
, PUNCT O
with ADP O
the DET O
goal NOUN O
of ADP O
a DET O
90 NUM O
% NOUN O
reduction NOUN O
in ADP O
global ADJ O
measles NOUN O
deaths NOUN O
( PUNCT O
compared VERB O
with ADP O
2000 NUM O
levels NOUN O
) PUNCT O
by ADP O
2010 NUM O
. PUNCT O

This DET O
study NOUN O
is AUX O
reported VERB O
as ADP O
per ADP O
Strengthening VERB B-LF
the DET I-LF
Reporting PROPN I-LF
of ADP I-LF
Observational PROPN I-LF
Studies PROPN I-LF
in ADP I-LF
Epidemiology PROPN I-LF
( PUNCT O
STROBE PROPN B-AC
) PUNCT O
guidelines NOUN O
( PUNCT O
S1 PROPN O
Checklist PROPN O
) PUNCT O
. PUNCT O

The DET O
predictive ADJ O
ability NOUN O
of ADP O
the DET O
model NOUN O
was AUX O
assessed VERB O
by ADP O
determining VERB O
the DET O
discrimination NOUN O
, PUNCT O
using VERB O
the DET O
area NOUN B-LF
under ADP I-LF
the DET I-LF
curve NOUN I-LF
of ADP I-LF
receiver NOUN I-LF
operator NOUN I-LF
characteristics NOUN I-LF
( PUNCT O
AUROC PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
its PRON O
calibration NOUN O
. PUNCT O

The DET O
quality NOUN O
terms NOUN O
come VERB O
from ADP O
the DET O
Phenotype PROPN B-LF
and CCONJ I-LF
Trait PROPN I-LF
Ontology PROPN I-LF
( PUNCT O
PATO PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
is AUX O
designed VERB O
to PART O
be AUX O
used VERB O
in ADP O
combination NOUN O
with ADP O
species ADJ O
- ADJ O
specific ADJ O
anatomical ADJ O
ontologies NOUN O
or CCONJ O
other ADJ O
cross ADJ O
- ADJ O
species ADJ O
entity NOUN O
ontologies NOUN O
( PUNCT O
see VERB O
, PUNCT O
for ADP O
example NOUN O
, PUNCT O
[ X O
11]–[13 X O
] PUNCT O
) PUNCT O
. PUNCT O

Sections NOUN O
( PUNCT O
5 NUM O
μm NOUN O
) PUNCT O
were AUX O
stained VERB O
with ADP O
hematoxylin NOUN B-LF
– PUNCT I-LF
eosin NOUN I-LF
( PUNCT O
HE PROPN B-AC
) PUNCT O
. PUNCT O
For ADP O
whole ADJ O
- PUNCT O
mount NOUN O
analysis NOUN O
, PUNCT O
mammary ADJ O
glands NOUN O
were AUX O
harvested VERB O
and CCONJ O
fixed VERB O
in ADP O
Carnoy PROPN O
’s PART O
solution NOUN O
( PUNCT O
6:3:1 NUM O
of ADP O
100 NUM O
% NOUN O
ethanol NOUN O
, PUNCT O
chloroform NOUN O
, PUNCT O
and CCONJ O
glacial ADJ O
acetic ADJ O
acid NOUN O
) PUNCT O
and CCONJ O
stained VERB O
with ADP O
Carmine PROPN O
alum NOUN O
. PUNCT O

Immunohistochemistry NOUN B-LF
( PUNCT O
IHC NOUN B-AC
) PUNCT O
detected VERB O
MET PROPN B-AC
expression NOUN O
in ADP O
the DET O
ducts NOUN O
of ADP O
METfl NOUN O
/ SYM O
fl NOUN O
and CCONJ O
MET-/- NOUN B-AC
mice NOUN O
. PUNCT O

In ADP O
GP PROPN O
visits NOUN O
for SCONJ O
the DET O
one NUM O
- PUNCT O
off NOUN O
Healthy PROPN B-LF
Kids PROPN I-LF
Check PROPN I-LF
( PUNCT O
HKC PROPN B-AC
) PUNCT O
prior ADV O
to PART O
school NOUN O
entry NOUN O
( PUNCT O
that PRON O
stopped VERB O
being AUX O
reimbursed VERB O
in ADP O
November PROPN O
2015 NUM O
, PUNCT O
and CCONJ O
was AUX O
rescinded VERB O
in ADP O
July PROPN O
2016 NUM O
) PUNCT O
, PUNCT O
there PRON O
were VERB O
several ADJ O
opportunities NOUN O
for SCONJ O
the DET O
family NOUN O
to PART O
discuss VERB O
WCC PROPN B-AC
activities NOUN O
. PUNCT O

Patients NOUN O
were AUX O
recruited VERB O
by ADP O
their PRON O
treating VERB O
clinicians NOUN O
to ADP O
CASCADE PROPN B-AC
, PUNCT O
a DET O
prospective ADJ B-LF
community NOUN I-LF
- PUNCT I-LF
based VERB I-LF
rapid ADJ I-LF
autopsy NOUN I-LF
program NOUN I-LF
[ X O
9 NUM O
] X O
conducted VERB O
in ADP O
association NOUN O
with ADP O
the DET O
Kathleen PROPN B-LF
Cuningham PROPN I-LF
Foundation PROPN I-LF
Consortium PROPN I-LF
for ADP I-LF
Research PROPN I-LF
into ADP I-LF
Familial PROPN I-LF
Breast PROPN I-LF
Cancer PROPN I-LF
( PUNCT O
kConFab PROPN B-AC
) PUNCT O
and CCONJ O
approved VERB O
by ADP O
the DET O
Human PROPN O
Research PROPN O
Ethics PROPN O
Committee PROPN O
of ADP O
the DET O
Peter PROPN O
MacCallum PROPN O
Cancer PROPN O
Centre PROPN O
, PUNCT O
Melbourne PROPN O
( PUNCT O
HREC PROPN O
approval NOUN O
numbers NOUN O
: PUNCT O
CASCADE PROPN B-AC
13/122 NUM O
, PUNCT O
kConFab PROPN B-AC
92/97 NUM O
and CCONJ O
11/102 NUM O
) PUNCT O
. PUNCT O

Of ADP O
this DET O
number NOUN O
, PUNCT O
nearly ADV O
82 NUM O
% NOUN O
had VERB O
Multidrug NOUN O
resistance NOUN O
- PUNCT O
TB PROPN B-AC
( PUNCT O
MDR PROPN O
- PUNCT O
TB PROPN B-AC
) PUNCT O
caused VERB O
by ADP O
MTBC PROPN B-AC
resistant ADJ O
to ADP O
both CCONJ O
rifampicin NOUN B-LF
( PUNCT O
RIF PROPN B-AC
) PUNCT O
and CCONJ O
isoniazid NOUN B-LF
( PUNCT O
INH PROPN B-AC
) PUNCT O
[ PUNCT O
2 NUM O
] PUNCT O
. PUNCT O

Data NOUN O
were AUX O
extracted VERB O
through ADP O
a DET O
standardized ADJ O
form NOUN O
, PUNCT O
which PRON O
was AUX O
in ADP O
accordance NOUN O
with ADP O
the DET O
Preferred PROPN B-LF
Reporting PROPN I-LF
Items PROPN I-LF
for ADP I-LF
Systematic PROPN I-LF
reviews PROPN I-LF
and CCONJ I-LF
Meta PROPN I-LF
- PROPN I-LF
Analyses PROPN I-LF
( PUNCT O
PRISMA PROPN B-AC
) PUNCT O
statement NOUN O
[ PUNCT O
16 NUM O
] PUNCT O
. PUNCT O

Twenty NUM O
- PUNCT O
nine NUM O
healthy ADJ O
, PUNCT O
moderately ADV O
- PUNCT O
active ADJ O
men NOUN O
( PUNCT O
mean NOUN O
± SYM O
SD NOUN B-AC
; PUNCT O
age NOUN O
24.5 NUM O
± SYM O
4.7 NUM O
y NOUN O
; PUNCT O
body NOUN O
mass NOUN O
74.9 NUM O
± SYM O
10.8 NUM O
kg NOUN O
; PUNCT O
height NOUN O
179.7 NUM O
± SYM O
6.5 NUM O
cm NOUN O
) PUNCT O
performed VERB O
either CCONJ O
resistance NOUN O
- PUNCT O
only ADV O
training NOUN O
( PUNCT O
RT NOUN B-AC
, PUNCT O
n NOUN O
= SYM O
9 NUM O
) PUNCT O
, PUNCT O
or CCONJ O
same ADJ O
- PUNCT O
day NOUN O
concurrent ADJ O
training NOUN O
whereby SCONJ O
high ADJ B-LF
- PUNCT I-LF
intensity NOUN I-LF
interval NOUN I-LF
training NOUN I-LF
was AUX O
performed VERB O
either CCONJ O
3 NUM O
hours NOUN O
before ADP O
( PUNCT O
HIIT+RT NOUN B-AC
, PUNCT O
n NOUN O
= SYM O
10 NUM O
) PUNCT O
or CCONJ O
after ADP O
resistance NOUN O
training NOUN O
( PUNCT O
RT+HIIT NOUN B-AC
, PUNCT O
n NOUN O
= SYM O
10 NUM O
) PUNCT O
, PUNCT O
for ADP O
3 NUM O
d.wk-1 NOUN B-AC
over ADP O
9 NUM O
weeks NOUN O
. PUNCT O

Both CCONJ O
CSR PROPN B-AC
and CCONJ O
SHM PROPN B-AC
are AUX O
initiated VERB O
by ADP O
and CCONJ O
critically ADV O
dependent ADJ O
upon SCONJ O
the DET O
expression NOUN O
of ADP O
the DET O
enzyme NOUN O
activation NOUN B-LF
- PUNCT I-LF
induced VERB I-LF
cytidine NOUN I-LF
deaminase NOUN I-LF
( PUNCT O
AID PROPN B-AC
) PUNCT O
[ PUNCT O
17 NUM O
] PUNCT O
. PUNCT O

The DET O
authors NOUN O
said VERB O
that SCONJ O
they PRON O
used VERB O
the DET O
Child PROPN B-LF
Feeding PROPN I-LF
Questionnaire PROPN I-LF
for ADP I-LF
adolescents NOUN I-LF
( PUNCT O
CFQ PROPN B-AC
- PUNCT B-AC
A PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
that SCONJ O
, PUNCT O
for ADP O
this DET O
study NOUN O
, PUNCT O
the DET O
questionnaire NOUN O
was AUX O
translated VERB O
into ADP O
German ADJ O
language NOUN O
. PUNCT O

cTN NOUN O
= PUNCT O
total ADJ O
nitrogen NOUN O
, PUNCT O
TP NOUN B-AC
= PUNCT O
total ADJ B-LF
phosphorus NOUN I-LF
, PUNCT O
TK NOUN B-AC
= PUNCT O
total ADJ B-LF
potassium NOUN I-LF
, PUNCT O
AN NOUN B-AC
= PUNCT O
available ADJ B-LF
nitrogen NOUN I-LF
, PUNCT O
AK NOUN B-AC
= PUNCT O
available ADJ B-LF
potassium NOUN I-LF
, PUNCT O
AP NOUN B-AC
= PUNCT O
available ADJ B-LF
phosphorus NOUN I-LF
, PUNCT O
SMC PROPN B-AC
= PUNCT O
soil NOUN B-LF
moisture NOUN I-LF
content NOUN I-LF
. PUNCT O

Abbreviations NOUN O
: PUNCT O
BMI PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
DI PROPN B-AC
, PUNCT O
Dietary PROPN B-LF
Index PROPN I-LF
; PUNCT O
EPIC PROPN B-AC
, PUNCT O
European PROPN B-LF
Prospective PROPN I-LF
Investigation PROPN I-LF
into ADP I-LF
Cancer PROPN I-LF
and CCONJ I-LF
Nutrition PROPN I-LF
; PUNCT O
FSAm PROPN B-AC
- PUNCT B-AC
NPS PROPN B-AC
, PUNCT O
Nutrient PROPN O
Profiling PROPN O
System PROPN O
of ADP O
the DET O
British PROPN O
Food PROPN O
Standards PROPN O
Agency PROPN O
( PUNCT O
modified VERB O
version NOUN O
) PUNCT O
; PUNCT O
HR NOUN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
. PUNCT O

The DET O
Field PROPN B-LF
Health PROPN I-LF
Services PROPN I-LF
Information PROPN I-LF
System PROPN I-LF
( PUNCT O
FHSIS PROPN B-AC
) PUNCT O
[ PUNCT O
43 NUM O
] PUNCT O
, PUNCT O
which PRON O
is AUX O
managed VERB O
by ADP O
the DET O
DOH PROPN B-AC
, PUNCT O
contains VERB O
the DET O
official ADJ O
health NOUN O
data NOUN O
of ADP O
the DET O
Philippine ADJ O
government NOUN O
. PUNCT O

To PART O
determine VERB O
which PRON O
parameter NOUN O
underlies VERB O
predominantly ADV O
the DET O
slowness NOUN O
of ADP O
the DET O
HRF NOUN B-AC
in ADP O
S1BF PROPN B-AC
, PUNCT O
we PRON O
generated VERB O
different ADJ O
HRFs NOUN B-AC
using VERB O
prior ADJ O
values NOUN O
of ADP O
the DET O
hemodynamic ADJ O
parameters NOUN O
, PUNCT O
with ADP O
the DET O
exception NOUN O
of ADP O
one NUM O
parameter NOUN O
, PUNCT O
which PRON O
was AUX O
set VERB O
to PART O
the DET O
value NOUN O
estimated VERB O
in ADP O
S1BF PROPN B-AC
( PUNCT O
Figure PROPN O
3B NUM O
) PUNCT O
. PUNCT O
This PRON O
allowed VERB O
us PRON O
to PART O
conclude VERB O
that SCONJ O
the DET O
strong ADJ O
decrease NOUN O
of ADP O
the DET O
autoregulation NOUN O
constant NOUN O
γ NOUN O
, PUNCT O
instantiating VERB O
a DET O
stable ADJ O
feedback NOUN O
of ADP O
changes NOUN O
in ADP O
cerebral ADJ B-LF
blood NOUN I-LF
flow NOUN I-LF
( PUNCT O
CBF PROPN B-AC
) PUNCT O
on ADP O
vasodilatatory ADJ O
effects NOUN O
( PUNCT O
see VERB O
Equation NOUN O
1 NUM O
) PUNCT O
, PUNCT O
is AUX O
the DET O
main ADJ O
cause NOUN O
of ADP O
the DET O
pathological ADJ O
hemodynamics NOUN O
observed VERB O
. PUNCT O

Subsequently ADV O
, PUNCT O
several ADJ O
additional ADJ O
compounds NOUN O
have VERB O
been AUX O
reported VERB O
to PART O
specifically ADV O
inhibit VERB O
the DET O
NLRP3 PROPN B-AC
inflammasome NOUN O
pathway NOUN O
, PUNCT O
but CCONJ O
the DET O
majority NOUN O
of ADP O
these DET O
agents NOUN O
have VERB O
weak ADJ O
activity NOUN O
against ADP O
the DET O
NLRP3 PROPN B-AC
inflammasome NOUN O
pathway NOUN O
( PUNCT O
μM PROPN O
IC50 NUM B-AC
concentrations NOUN O
) PUNCT O
and CCONJ O
may AUX O
target VERB O
nuclear ADJ B-LF
factor NOUN I-LF
κB PROPN I-LF
( PUNCT O
NF PROPN B-AC
- NOUN B-AC
κB PROPN B-AC
) PUNCT O
signaling NOUN O
and CCONJ O
other ADJ O
immune ADJ O
pathways NOUN O
( PUNCT O
reviewed VERB O
in ADP O
[ X O
10 NUM O
] PUNCT O
) PUNCT O
. PUNCT O

The DET O
mammograms NOUN O
were AUX O
processed VERB O
using VERB O
a DET O
volumetric ADJ B-LF
breast NOUN I-LF
density NOUN I-LF
( PUNCT O
VBD PROPN B-AC
) PUNCT O
measurement NOUN O
software NOUN O
( PUNCT O
Volpara PROPN O
) PUNCT O
to PART O
assess VERB O
compression NOUN O
force NOUN O
, PUNCT O
compression NOUN O
pressure NOUN O
, PUNCT O
compressed ADJ B-LF
breast NOUN I-LF
thickness NOUN I-LF
( PUNCT O
CBT PROPN B-AC
) PUNCT O
, PUNCT O
breast NOUN O
volume NOUN O
, PUNCT O
VBD PROPN B-AC
and CCONJ O
MGD PROPN B-AC
against ADP O
breast NOUN O
contact NOUN O
area NOUN O
. PUNCT O

b X O
CI NOUN B-AC
; PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
. PUNCT O

In ADP O
order NOUN O
to PART O
have AUX O
a DET O
better ADJ O
understanding NOUN O
of ADP O
how SCONJ O
these DET O
Hbs NOUN B-AC
are AUX O
affected VERB O
by ADP O
the DET O
symbiosis NOUN O
and CCONJ O
their PRON O
environment NOUN O
, PUNCT O
we PRON O
evaluated VERB O
hemoglobin NOUN B-LF
gene NOUN O
expression NOUN O
in ADP O
different ADJ O
juvenile ADJ O
clam NOUN O
tissues NOUN O
at ADP O
the DET O
RNA NOUN O
level NOUN O
, PUNCT O
comparing VERB O
two NUM O
groups NOUN O
of ADP O
clams NOUN O
living VERB O
in ADP O
two NUM O
different ADJ O
environments NOUN O
, PUNCT O
sulfide NOUN O
- PUNCT O
rich ADJ O
and CCONJ O
sulfide NOUN O
- PUNCT O
poor ADJ O
. PUNCT O

GT PROPN B-AC
uses VERB O
internet NOUN B-LF
protocol NOUN I-LF
( PUNCT O
IP NOUN B-AC
) PUNCT O
addresses NOUN O
from ADP O
server NOUN O
logs NOUN O
to PART O
assign VERB O
the DET O
origin NOUN O
of ADP O
web NOUN O
search NOUN O
queries NOUN O
. PUNCT O

ChIP NOUN B-AC
- PUNCT O
qPCR NOUN O
, PUNCT O
chromatin NOUN B-LF
immunoprecipitation NOUN I-LF
followed VERB O
by ADP O
quantitative ADJ O
PCR NOUN O
. PUNCT O

AA PROPN O
, PUNCT O
amino NOUN O
acid NOUN O
; PUNCT O
ACE2 PROPN B-AC
, PUNCT O
angiotensin NOUN B-LF
converting VERB I-LF
enzyme NOUN I-LF
2 NUM I-LF
; PUNCT O
COVID-19 PROPN B-AC
, PUNCT O
coronavirus NOUN B-LF
disease NOUN I-LF
2019 NUM I-LF
; PUNCT O
FP PROPN O
, PUNCT O
fusion NOUN O
peptide NOUN O
; PUNCT O
HR1 PROPN O
, PUNCT O
heptad NOUN O
repeat NOUN O
1 NUM O
; PUNCT O
NTD PROPN O
, PUNCT O
N NOUN O
- PUNCT O
terminal ADJ O
domain NOUN O
; PUNCT O
RBD PROPN B-AC
, PUNCT O
receptor NOUN B-LF
- PUNCT I-LF
binding VERB I-LF
domain NOUN I-LF
; PUNCT O
RBM PROPN O
, PUNCT O
receptor NOUN O
- PUNCT O
binding VERB O
motif NOUN O
; PUNCT O
S PROPN O
, PUNCT O
spike NOUN O
; PUNCT O
SARS PROPN B-AC
- PUNCT B-AC
CoV-2 PROPN B-AC
, PUNCT O
severe ADJ B-LF
acute ADJ I-LF
respiratory ADJ I-LF
syndrome NOUN I-LF
coronavirus NOUN I-LF
2 NUM I-LF
. PUNCT O

The DET O
open ADJ O
structure NOUN O
of ADP O
P. NOUN O
aeruginosa NOUN O
lipase NOUN O
was AUX O
obtained VERB O
from ADP O
the DET O
Protein PROPN B-LF
Data PROPN I-LF
Bank PROPN I-LF
( PUNCT O
PDB PROPN B-AC
) PUNCT O
. PUNCT O
This PRON O
was AUX O
solvated VERB O
in ADP O
explicit ADJ O
water NOUN O
and CCONJ O
energy NOUN O
minimized VERB O
. PUNCT O

SD NOUN B-AC
: PUNCT O
standard ADJ B-LF
deviation NOUN I-LF
. PUNCT O

IQR PROPN B-AC
, PUNCT O
Interquartile ADJ B-LF
range NOUN I-LF
; PUNCT O
SO2 PROPN O
, PUNCT O
oxygen NOUN O
saturation NOUN O
; PUNCT O
BPS PROPN O
, PUNCT O
blood NOUN O
pressure NOUN O
systolic NOUN O
; PUNCT O
BPD PROPN O
, PUNCT O
blood NOUN O
pressure NOUN O
diastolic NOUN O
; PUNCT O
PR NOUN O
, PUNCT O
pulse NOUN O
rate NOUN O
; PUNCT O
ED PROPN B-AC
, PUNCT O
emergency NOUN B-LF
department NOUN I-LF
; PUNCT O
COPD PROPN B-AC
, PUNCT O
chronic ADJ B-LF
obstructive ADJ I-LF
pulmonary ADJ I-LF
disease NOUN I-LF
; PUNCT O
WBC PROPN O
, PUNCT O
white ADJ O
blood NOUN O
cell NOUN O
count NOUN O
; PUNCT O
ProADM PROPN B-AC
, PUNCT O
pro ADJ O
- ADJ O
adrenomedullin NOUN O
; PUNCT O
ICU PROPN B-AC
, PUNCT O
intensive ADJ B-LF
care NOUN I-LF
unit NOUN I-LF
. PUNCT O

bpMRI NOUN B-AC
, PUNCT O
biparametric ADJ B-LF
magnetic ADJ I-LF
resonance NOUN I-LF
imaging NOUN I-LF
; PUNCT O
NPV NOUN B-AC
, PUNCT O
negative ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
; PUNCT O
PPV NOUN O
, PUNCT O
positive ADJ O
predictive ADJ O
value NOUN O
; PUNCT O
PSA PROPN B-AC
, PUNCT O
prostate NOUN B-LF
specific ADJ I-LF
antigen NOUN I-LF
. PUNCT O

Abbreviations NOUN O
: PUNCT O
BMI PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
WC PROPN O
, PUNCT O
waist NOUN O
circumference NOUN O
; PUNCT O
FBG PROPN O
, PUNCT O
fasting ADJ O
blood NOUN O
glucose NOUN O
; PUNCT O
SBP PROPN B-AC
, PUNCT O
systolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
; PUNCT O
AST PROPN B-AC
, PUNCT O
aspartate NOUN O
aminotransferase NOUN O
; PUNCT O
ALT PROPN O
, PUNCT O
alanine NOUN O
aminotransferase NOUN O
; PUNCT O
LDL PROPN B-AC
, PUNCT O
low ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
; PUNCT O
HDL PROPN B-AC
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
; PUNCT O
hs NOUN B-AC
- PUNCT B-AC
CRP PROPN B-AC
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
sensitivity NOUN I-LF
C NOUN I-LF
- PUNCT I-LF
reactive NOUN I-LF
protein NOUN I-LF
; PUNCT O
APRI PROPN B-AC
, PUNCT O
aspartate NOUN O
aminotransferase NOUN O
- PUNCT O
to ADP O
- PUNCT O
platelet NOUN O
ratio NOUN O
index NOUN O
. PUNCT O

Myofibroblasts NOUN O
are AUX O
characterized VERB O
by ADP O
excessive ADJ O
production NOUN O
of ADP O
ECM PROPN B-AC
components NOUN O
and CCONJ O
the DET O
alpha NOUN B-LF
- PUNCT I-LF
smooth ADJ I-LF
muscle NOUN I-LF
actin NOUN I-LF
( PUNCT O
αSMA PROPN B-AC
) PUNCT O
containing VERB O
stress NOUN O
fiber NOUN O
formation NOUN O
which PRON O
contributes VERB O
to ADP O
contraction NOUN O
of ADP O
the DET O
tissue NOUN O
[ PUNCT O
10 NUM O
] PUNCT O
. PUNCT O

To PART O
overcome VERB O
these DET O
difficulties NOUN O
, PUNCT O
we PRON O
recently ADV O
developed VERB O
a DET O
simple ADJ O
measure NOUN O
of ADP O
intra ADJ O
- PUNCT O
tumor NOUN O
genetic ADJ O
heterogeneity NOUN O
[ X O
30,31 NUM O
] PUNCT O
based VERB O
on ADP O
whole ADJ B-LF
- PUNCT I-LF
exome NOUN I-LF
sequencing NOUN I-LF
( PUNCT O
WES PROPN B-AC
) PUNCT O
of ADP O
tumor NOUN O
and CCONJ O
matched VERB O
normal ADJ O
DNA NOUN O
. PUNCT O
With SCONJ O
WES PROPN B-AC
expected VERB O
to PART O
play VERB O
a DET O
significant ADJ O
role NOUN O
soon ADV O
in ADP O
clinical ADJ O
oncology NOUN O
[ X O
8,32 NUM O
] PUNCT O
, PUNCT O
a DET O
measure NOUN O
of ADP O
heterogeneity NOUN O
based VERB O
on ADP O
this DET O
technology NOUN O
could AUX O
be AUX O
widely ADV O
used VERB O
in ADP O
practice NOUN O
. PUNCT O

Next ADV O
, PUNCT O
we PRON O
investigated VERB O
the DET O
effect NOUN O
of ADP O
high ADJ B-LF
- PUNCT I-LF
fat NOUN I-LF
diet NOUN I-LF
( PUNCT O
HFD PROPN B-AC
) PUNCT O
on ADP O
metabolic ADJ O
parameters NOUN O
of ADP O
TLR2 PROPN B-AC
KO PROPN B-AC
mice NOUN O
. PUNCT O

Edges NOUN O
of ADP O
the DET O
phylogeny NOUN O
were AUX O
arbitrarily ADV O
colored VERB O
for ADP O
illustrative ADJ O
purposes NOUN O
. PUNCT O
( PUNCT O
B NOUN O
) PUNCT O
The DET O
distribution NOUN O
of ADP O
gold ADJ B-LF
standard ADJ I-LF
viral ADJ I-LF
load NOUN I-LF
( PUNCT O
GSVL PROPN B-AC
) PUNCT O
over ADP O
evolutionary ADJ O
time NOUN O
( PUNCT O
as SCONJ O
quantified VERB O
by ADP O
root NOUN O
- PUNCT O
to ADP O
- PUNCT O
tip NOUN O
distance NOUN O
[ PUNCT O
i.e. X O
, PUNCT O
distance NOUN O
from ADP O
the DET O
common ADJ O
ancestor NOUN O
as SCONJ O
assessed VERB O
by ADP O
the DET O
phylogeny NOUN O
] PUNCT O
) PUNCT O
. PUNCT O

In ADP O
this DET O
study NOUN O
, PUNCT O
we PRON O
chose VERB O
the DET O
best ADJ O
cluster NOUN O
number NOUN O
( PUNCT O
K NOUN O
= SYM O
4 NUM O
) PUNCT O
using VERB O
subject ADJ O
matter NOUN O
expertise NOUN O
based VERB O
on ADP O
a DET O
combination NOUN O
of ADP O
factors NOUN O
( PUNCT O
log NOUN O
- PUNCT O
rank NOUN O
p NOUN O
< ADP O
0.05 NUM O
; PUNCT O
S1 PROPN O
Fig PROPN O
and CCONJ O
S2 PROPN O
Table PROPN O
): PUNCT O
( PUNCT O
i X O
) PUNCT O
significantly ADV O
distinguishable ADJ O
survival NOUN O
rate NOUN O
and CCONJ O
cardiovascular ADJ O
outcome NOUN O
by ADP O
Kaplan PROPN B-LF
– PUNCT I-LF
Meier PROPN I-LF
( PUNCT O
KM PROPN B-AC
) PUNCT O
estimator NOUN O
with ADP O
log NOUN O
- PUNCT O
rank NOUN O
test NOUN O
; PUNCT O
and CCONJ O
( PUNCT O
ii X O
) PUNCT O
the DET O
highest ADJ O
number NOUN O
of ADP O
clusters NOUN O
to PART O
identify VERB O
more ADJ O
new ADJ O
patient NOUN O
subgroups NOUN O
. PUNCT O

Other ADJ O
methodologies NOUN O
have AUX O
been AUX O
proposed VERB O
: PUNCT O
adaptive ADJ O
threshold NOUN O
that PRON O
allows VERB O
consideration NOUN O
of ADP O
the DET O
background NOUN O
activity NOUN O
or CCONJ O
more ADV O
sophisticated ADJ O
methods NOUN O
such ADJ O
as ADP O
fuzzy ADJ B-LF
C PROPN I-LF
mean NOUN I-LF
( PUNCT O
FCM PROPN B-AC
) PUNCT O
and CCONJ O
fuzzy ADJ B-LF
locally ADV I-LF
adaptive ADJ I-LF
Bayesian PROPN I-LF
( PUNCT O
FLAB PROPN B-AC
) PUNCT O
algorithms NOUN O
[ PUNCT O
4 NUM O
] PUNCT O
. PUNCT O

To ADP O
this DET O
end NOUN O
, PUNCT O
we PRON O
performed VERB O
RNA NOUN B-LF
interference NOUN I-LF
( PUNCT O
RNAi)-mediated NOUN B-AC
knockdowns NOUN O
of ADP O
Hh NOUN B-AC
and CCONJ O
Dpp NOUN B-AC
levels NOUN O
by ADP O
expressing VERB O
RNAi NOUN B-AC
lines NOUN O
under ADP O
the DET O
control NOUN O
of ADP O
GMR PROPN B-AC
- PUNCT O
Gal4 PROPN O
while SCONJ O
simultaneously ADV O
inducing VERB O
apoptosis NOUN O
using VERB O
UAS PROPN O
- PUNCT O
rpr NOUN O
. PUNCT O

2D ADJ B-LF
HeLa PROPN I-LF
dataset NOUN I-LF

Gene PROPN O
completeness NOUN O
was AUX O
assessed VERB O
by ADP O
comparing VERB O
sets NOUN O
of ADP O
core ADJ O
eukaryotic ADJ O
genes NOUN O
to ADP O
each DET O
reference NOUN O
assembly NOUN O
using VERB O
Core PROPN B-LF
Eukaryotic PROPN I-LF
Gene PROPN I-LF
Mapping PROPN I-LF
Approach PROPN I-LF
( PUNCT O
CEGMA PROPN B-AC
) PUNCT O
and CCONJ O
Benchmarking VERB B-LF
Universal PROPN I-LF
Single PROPN I-LF
- PUNCT I-LF
Copy PROPN I-LF
Orthologs PROPN I-LF
( PUNCT O
BUSCO PROPN B-AC
) PUNCT O
[ X O
44,45 NUM O
] PUNCT O
. PUNCT O

Human ADJ B-LF
Exonic ADJ I-LF
Evidence NOUN I-LF
- PUNCT I-LF
Based VERB I-LF
Oligonucleotide NOUN I-LF
( PUNCT O
HEEBO PROPN B-AC
) PUNCT O
microarrays NOUN O
( PUNCT O
Microarrays NOUN O
, PUNCT O
Nashville PROPN O
, PUNCT O
Tennessee PROPN O
) PUNCT O
were AUX O
used VERB O
to PART O
analyze VERB O
changes NOUN O
in ADP O
gene NOUN O
expression NOUN O
within ADP O
the DET O
PFC PROPN B-AC
. PUNCT O
Four NUM O
μg NOUN O
of ADP O
total ADJ O
RNA NOUN O
( PUNCT O
RIN NOUN O
> SYM O
5.0 NUM O
, PUNCT O
A260/280 NUM O
> SYM O
2.0 NUM O
) PUNCT O
from ADP O
PTSD PROPN B-AC
( PUNCT O
n NOUN O
= SYM O
6 NUM O
) PUNCT O
and CCONJ O
matched VERB O
control NOUN O
human ADJ O
samples NOUN O
( PUNCT O
n NOUN O
= SYM O
6 NUM O
) PUNCT O
were AUX O
reverse ADV O
transcribed VERB O
into ADP O
cDNA NOUN O
and CCONJ O
indirectly ADV O
labeled VERB O
with ADP O
highly ADV O
sensitive ADJ O
fluorescent ADJ O
technology NOUN O
( PUNCT O
Genisphere PROPN O
, PUNCT O
Hatfield PROPN O
, PUNCT O
Pennsylvania PROPN O
) PUNCT O
. PUNCT O

LA PROPN B-AC
: PUNCT O
left ADJ B-LF
atrium NOUN I-LF
. PUNCT O

Interestingly ADV O
, PUNCT O
the DET O
transcriptomic ADJ O
patterns NOUN O
of ADP O
the DET O
brain NOUN O
and CCONJ O
peripheral ADJ B-LF
blood NOUN I-LF
mononuclear ADJ I-LF
cells NOUN I-LF
( PUNCT O
PBMCs NOUN B-AC
) PUNCT O
overlap VERB O
, PUNCT O
about ADV O
80 NUM O
% NOUN O
[ PUNCT O
16 NUM O
] PUNCT O
. PUNCT O

6 X O
. PUNCT O
Discussion NOUN O
: PUNCT O
1 X O
) PUNCT O
Line NOUN O
217 NUM O
- SYM O
220 NUM O
: PUNCT O
typo NOUN O
and CCONJ O
consider VERB O
use NOUN O
of ADP O
standard ADJ O
reference NOUN O
for ADP O
“ PUNCT O
mean ADJ O
difference NOUN O
” PUNCT O
( PUNCT O
bias NOUN O
) PUNCT O
as ADP O
the DET O
quantified VERB O
degree NOUN O
of ADP O
agreement NOUN O
and CCONJ O
“ PUNCT O
limits NOUN B-LF
of ADP I-LF
agreement NOUN I-LF
” PUNCT O
( PUNCT O
precision NOUN O
) PUNCT O
as ADP O
SD NOUN B-AC
and CCONJ O
the DET O
95 NUM O
% NOUN O
LOAs NOUN B-AC
. PUNCT O
2 X O
) PUNCT O
Line NOUN O
240 NUM O
– PUNCT O
this PRON O
statement NOUN O
re ADP O
: PUNCT O
“ PUNCT O
… PUNCT O
although SCONJ O
this PRON O
was AUX O
not PART O
statistically ADV O
significant ADJ O
” PUNCT O
was AUX O
not PART O
clear ADJ O
to ADP O
me PRON O
. PUNCT O
3 X O
) PUNCT O
Line NOUN O
266 NUM O
- SYM O
270 NUM O
: PUNCT O
recommend VERB O
using VERB O
hypothermic ADJ O
and CCONJ O
febrile ADJ O
range NOUN O
temperatures NOUN O
. PUNCT O

In ADP O
2003 NUM O
and CCONJ O
2009 NUM O
, PUNCT O
Carmichael PROPN O
et PROPN O
al NOUN O
. PUNCT O
focused VERB O
on ADP O
both CCONJ O
conotruncal ADJ O
defects NOUN O
: PUNCT O
Tetralogy PROPN B-LF
Of ADP I-LF
Fallot PROPN I-LF
( PUNCT O
TOF PROPN B-AC
) PUNCT O
and CCONJ O
dextro ADJ O
- PUNCT O
Transposition PROPN O
of ADP O
Great PROPN O
Arteries PROPN O
( PUNCT O
dTGA)[9,27 NOUN O
] PUNCT O
. PUNCT O

A DET O
root NOUN B-LF
- PUNCT I-LF
mean NOUN I-LF
– PUNCT I-LF
squared VERB I-LF
deviation NOUN I-LF
( PUNCT O
RMSD PROPN B-AC
) PUNCT O
value NOUN O
, PUNCT O
or CCONJ O
any DET O
linear ADJ O
transformation NOUN O
of ADP O
this PRON O
, PUNCT O
often ADV O
remains VERB O
dependent ADJ O
on ADP O
the DET O
number NOUN O
of ADP O
aligned VERB O
residues NOUN O
. PUNCT O

Proportion NOUN O
of ADP O
patients NOUN O
meeting VERB O
at ADV O
least ADV O
one NUM O
of ADP O
nine NUM O
indicators NOUN O
of ADP O
high ADJ O
- PUNCT O
risk NOUN O
NSAID PROPN B-AC
and CCONJ O
anti ADJ O
- PUNCT O
platelet ADJ O
prescribing NOUN O
: PUNCT O
prescription NOUN O
of ADP O
a DET O
traditional ADJ O
oral ADJ O
NSAID PROPN B-AC
or CCONJ O
low ADJ O
- PUNCT O
dose NOUN O
aspirin NOUN O
in ADP O
patients NOUN O
with ADP O
a DET O
history NOUN O
of ADP O
peptic ADJ O
ulceration NOUN O
without ADP O
co NOUN O
- PUNCT O
prescription NOUN O
of ADP O
gastro NOUN O
- PUNCT O
protection;traditional NOUN O
oral ADJ O
NSAID PROPN B-AC
in ADP O
patients NOUN O
aged VERB O
75 NUM O
years NOUN O
or CCONJ O
over ADV O
without ADP O
co NOUN O
- PUNCT O
prescription NOUN O
of ADP O
gastro NOUN O
- PUNCT O
protection;traditional NOUN O
oral ADJ O
NSAID PROPN B-AC
and CCONJ O
aspirin NOUN O
in ADP O
patients NOUN O
aged VERB O
65 NUM O
years NOUN O
or CCONJ O
over ADV O
without ADP O
co NOUN O
- PUNCT O
prescription NOUN O
of ADP O
gastro NOUN O
- PUNCT O
protection;aspirin NOUN O
and CCONJ O
clopidogrel NOUN O
in ADP O
patients NOUN O
aged VERB O
65 NUM O
years NOUN O
or CCONJ O
over ADV O
without ADP O
co NOUN O
- PUNCT O
prescription NOUN O
of ADP O
gastro NOUN O
- PUNCT O
protection;warfarin NOUN O
and CCONJ O
traditional ADJ O
oral ADJ O
NSAID;warfarin PROPN B-AC
and CCONJ O
low ADJ O
- PUNCT O
dose NOUN O
aspirin NOUN O
or CCONJ O
clopidogrel NOUN O
without ADP O
co NOUN O
- PUNCT O
prescription NOUN O
of ADP O
gastro NOUN O
- PUNCT O
protection;oral NOUN O
NSAID PROPN B-AC
in ADP O
patients NOUN O
with ADP O
heart NOUN O
failure;oral NOUN O
NSAID PROPN B-AC
in ADP O
patients NOUN O
prescribed VERB O
both CCONJ O
a DET O
diuretic ADJ O
and CCONJ O
an DET O
angiotensin NOUN B-LF
- PUNCT I-LF
converting VERB I-LF
- PUNCT I-LF
enzyme NOUN I-LF
inhibitor NOUN I-LF
( PUNCT O
ACE PROPN B-AC
- PUNCT B-AC
I PROPN B-AC
) PUNCT O
or CCONJ O
angiotensin NOUN B-LF
receptor NOUN I-LF
blocker NOUN I-LF
( PUNCT O
ARB);oral PROPN B-AC
NSAID PROPN B-AC
in ADP O
patients NOUN O
with ADP O
chronic ADJ B-LF
kidney NOUN I-LF
disease NOUN I-LF
( PUNCT O
CKD PROPN B-AC
) PUNCT O
. PUNCT O

The DET O
Rho PROPN O
GTPases PROPN O
exhibit VERB O
guanine NOUN O
nucleotide NOUN O
– PUNCT O
binding VERB O
activity NOUN O
and CCONJ O
function VERB O
as ADP O
molecular ADJ O
switches NOUN O
, PUNCT O
cycling VERB O
between ADP O
an DET O
inactive ADJ O
GDP(guanosine NOUN B-LF
5′-bis NUM I-LF
phosphate)-bound VERB I-LF
form NOUN O
and CCONJ O
an DET O
active ADJ O
GTP PROPN B-AC
- PUNCT O
bound VERB O
form NOUN O
. PUNCT O

Interactions NOUN O
were AUX O
tested VERB O
between ADP O
variables NOUN O
in ADP O
the DET O
multivariable ADJ O
model NOUN O
, PUNCT O
and CCONJ O
all DET O
variables NOUN O
were AUX O
tested VERB O
for ADP O
their PRON O
inclusion NOUN O
and CCONJ O
interactions NOUN O
with ADP O
variables NOUN O
in ADP O
the DET O
final ADJ O
model NOUN O
. PUNCT O
95 NUM O
% NOUN O
confidence NOUN B-LF
intervals NOUN I-LF
( PUNCT O
CIs NOUN B-AC
) PUNCT O
for ADP O
the DET O
model NOUN O
fit NOUN O
were AUX O
calculated VERB O
from ADP O
the DET O
standard ADJ B-LF
error NOUN I-LF
( PUNCT O
SE NOUN B-AC
) PUNCT O
of ADP O
the DET O
fixed VERB O
effects NOUN O
. PUNCT O

For ADP O
PCA NOUN B-AC
model NOUN O
generation NOUN O
tissue NOUN O
type NOUN O
- PUNCT O
associated VERB O
spectra NOUN O
were AUX O
selected VERB O
with ADP O
the DET O
CytoSpec PROPN O
™ NUM O
software NOUN O
and CCONJ O
then ADV O
ROIs NOUN B-AC
( PUNCT O
regions NOUN B-LF
of ADP I-LF
interest NOUN I-LF
) PUNCT O
were AUX O
assigned VERB O
. PUNCT O

OR CCONJ B-AC
, PUNCT O
odds NOUN B-LF
ratio NOUN I-LF
. PUNCT O

Drosophila PROPN O
contains VERB O
a DET O
single ADJ O
myosin NOUN B-LF
heavy ADJ I-LF
chain NOUN I-LF
gene NOUN O
, PUNCT O
Mhc PROPN B-AC
. PUNCT O

Development NOUN O
of ADP O
an DET O
effective ADJ O
herpes NOUN B-LF
simplex NOUN I-LF
virus NOUN I-LF
type NOUN I-LF
2 NUM I-LF
( PUNCT O
HSV-2 PROPN B-AC
) PUNCT O
prophylactic ADJ O
vaccine NOUN O
is AUX O
a DET O
global ADJ O
priority NOUN O
to PART O
improve VERB O
sexual ADJ O
health NOUN O
[ X O
1,2 NUM O
] PUNCT O
. PUNCT O

A DET O
subset NOUN O
of ADP O
human ADJ O
cancers NOUN O
and CCONJ O
immortalized ADJ O
cell NOUN O
lines NOUN O
maintains VERB O
telomeres NOUN O
in ADP O
the DET O
absence NOUN O
of ADP O
telomerase NOUN O
activity NOUN O
using VERB O
the DET O
alternative ADJ B-LF
lengthening NOUN I-LF
of ADP I-LF
telomeres NOUN I-LF
( PUNCT O
ALT PROPN B-AC
) PUNCT O
pathway NOUN O
[ X O
1–3 NUM O
] PUNCT O
. PUNCT O

CKD PROPN B-AC
primitive ADJ O
diagnoses NOUN O
were AUX O
grouped VERB O
as ADP O
diabetic ADJ B-LF
nephropathy NOUN I-LF
( PUNCT O
DN PROPN B-AC
) PUNCT O
, PUNCT O
hypertensive ADJ B-LF
nephropathy NOUN I-LF
( PUNCT O
HTN PROPN B-AC
) PUNCT O
, PUNCT O
glomerulonephritis NOUN B-LF
( PUNCT O
GN PROPN B-AC
) PUNCT O
, PUNCT O
tubulo ADJ B-LF
- PUNCT I-LF
intersitial ADJ I-LF
nephritis NOUN I-LF
( PUNCT O
TIN PROPN B-AC
) PUNCT O
or CCONJ O
polycystic ADJ B-LF
kidney NOUN I-LF
disease NOUN I-LF
( PUNCT O
PKD PROPN B-AC
) PUNCT O
. PUNCT O
Diagnosis NOUN O
of ADP O
GN PROPN B-AC
was AUX O
biopsy NOUN O
- PUNCT O
proven VERB O
for ADP O
all DET O
patients NOUN O
. PUNCT O

Initially ADV O
, PUNCT O
tidal ADJ O
volume NOUN O
was AUX O
10 NUM O
mL NOUN O
x SYM O
kg-1 NOUN O
, PUNCT O
PEEP NOUN B-AC
5 NUM O
cm NOUN O
H2O NOUN O
, PUNCT O
respiratory ADJ O
rate NOUN O
25 NUM O
x SYM O
min-1 NOUN B-AC
and CCONJ O
inspired VERB B-LF
oxygen NOUN I-LF
fraction NOUN I-LF
( PUNCT O
FiO2 NOUN B-AC
) PUNCT O
0.3 NUM O
. PUNCT O

A DET O
NanoAnalyzer PROPN O
N30 PROPN O
instrument NOUN O
equipped VERB O
with ADP O
a DET O
dual ADJ O
488/640 NUM O
nm NOUN O
laser NOUN O
and CCONJ O
single ADJ B-LF
- PUNCT I-LF
photon NOUN I-LF
counting NOUN I-LF
avalanche NOUN I-LF
photodiodes NOUN I-LF
detectors NOUN I-LF
( PUNCT O
SPCM PROPN B-AC
APDs NOUN O
) PUNCT O
was AUX O
used VERB O
for ADP O
detection NOUN O
of ADP O
the DET O
EV PROPN B-AC
isolates NOUN O
. PUNCT O

EGFP PROPN O
, PUNCT O
enhanced ADJ O
green ADJ O
fluorescent ADJ O
protein NOUN O
; PUNCT O
iLID PROPN B-AC
, PUNCT O
improved ADJ B-LF
light NOUN I-LF
- PUNCT I-LF
induced VERB I-LF
dimer NOUN I-LF
; PUNCT O
MTOC PROPN B-AC
, PUNCT O
microtubule NOUN B-LF
organizing VERB I-LF
center NOUN I-LF
; PUNCT O
PACT PROPN B-AC
, PUNCT O
pericentrin NOUN B-LF
- PUNCT I-LF
AKAP-450 NOUN I-LF
containing VERB I-LF
targeting NOUN I-LF
; PUNCT O
SspB PROPN B-AC
, PUNCT O
Stringent ADJ B-LF
starvation NOUN I-LF
protein NOUN I-LF
B PROPN I-LF
; PUNCT O
UAS PROPN O
, PUNCT O
upstream ADJ O
activation NOUN O
sequence NOUN O
. PUNCT O

HA PROPN B-AC
, PUNCT O
haemagglutinin NOUN B-LF
; PUNCT O
HD PROPN B-AC
- PUNCT B-AC
MAP PROPN B-AC
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
microarray NOUN I-LF
patch NOUN I-LF
; PUNCT O
IM PROPN B-AC
, PUNCT O
intramuscular NOUN B-LF
. PUNCT O

Here ADV O
we PRON O
set VERB O
out ADP O
to PART O
find VERB O
an DET O
alternative ADJ O
sampling NOUN O
technique NOUN O
for ADP O
collecting VERB O
outdoor ADJ O
mosquitoes NOUN O
in ADP O
Lao PROPN O
PDR PROPN B-AC
. PUNCT O
In ADP O
the DET O
first ADJ O
experiment NOUN O
we PRON O
compared VERB O
the DET O
human NOUN B-LF
- PUNCT I-LF
baited VERB I-LF
double ADJ I-LF
net NOUN I-LF
trap NOUN O
( PUNCT O
HDN PROPN B-AC
) PUNCT O
, PUNCT O
CDC PROPN B-AC
light ADJ O
trap NOUN O
, PUNCT O
BG PROPN B-AC
Sentinel PROPN O
trap NOUN O
and CCONJ O
Suna PROPN O
trap NOUN O
. PUNCT O

At ADP O
the DET O
organelle NOUN O
level NOUN O
, PUNCT O
if SCONJ O
the DET O
lysosomal ADJ O
membrane NOUN O
is AUX O
mildly ADV O
damaged VERB O
by ADP O
insults NOUN O
like ADP O
lysosomotropic ADJ O
compounds NOUN O
, PUNCT O
such ADJ O
as ADP O
L NOUN B-LF
- PUNCT I-LF
leucyl NOUN I-LF
- PUNCT I-LF
L NOUN I-LF
- PUNCT I-LF
leucine NOUN I-LF
methyl NOUN I-LF
ester NOUN I-LF
( PUNCT O
LLOMe PROPN B-AC
) PUNCT O
or CCONJ O
iron NOUN O
- PUNCT O
dependent ADJ O
oxidative ADJ O
stress NOUN O
, PUNCT O
the DET O
endosomal ADJ B-LF
sorting VERB I-LF
complexes NOUN I-LF
required VERB I-LF
for ADP I-LF
transport NOUN I-LF
( PUNCT O
ESCRT PROPN B-AC
) PUNCT O
machinery NOUN O
can AUX O
be AUX O
recruited VERB O
to PART O
the DET O
lysosome NOUN O
surface NOUN O
to PART O
repair VERB O
the DET O
membrane NOUN O
[ X O
16–18 NUM O
] PUNCT O
. PUNCT O

As SCONJ O
T PROPN O
cell NOUN O
migration NOUN O
is AUX O
activated VERB O
by ADP O
several ADJ O
chemokines NOUN O
, PUNCT O
leading VERB O
to ADP O
different ADJ O
responses NOUN O
[ PUNCT O
11 NUM O
] PUNCT O
, PUNCT O
we PRON O
also ADV O
tested VERB O
the DET O
effect NOUN O
of ADP O
lactate NOUN O
on ADP O
chemokine NOUN B-LF
( PUNCT I-LF
C NOUN I-LF
- PUNCT I-LF
C NOUN I-LF
motif NOUN I-LF
) PUNCT I-LF
ligand NOUN I-LF
( PUNCT O
CCL)5 NOUN B-AC
- PUNCT O
induced VERB O
chemotaxis NOUN O
. PUNCT O

Key ADJ O
: PUNCT O
IHC PROPN B-AC
, PUNCT O
immunohistochemistry NOUN B-LF
; PUNCT O
INMB PROPN O
, PUNCT O
incremental ADJ O
net ADJ O
monetary ADJ O
benefit NOUN O
( PUNCT O
presented VERB O
per ADP O
proband NOUN O
) PUNCT O
; PUNCT O
QALY PROPN B-AC
, PUNCT O
quality NOUN B-LF
- PUNCT I-LF
adjusted VERB I-LF
life NOUN I-LF
years NOUN I-LF
; PUNCT O
WTP PROPN O
, PUNCT O
willingness NOUN O
- PUNCT O
to PART O
- PUNCT O
pay VERB O
; PUNCT O
S5 PROPN O
Appendix NOUN O
gives VERB O
details NOUN O
of ADP O
all DET O
parameter NOUN O
abbreviations NOUN O
. PUNCT O

For ADP O
each DET O
block NOUN O
group NOUN O
, PUNCT O
we PRON O
calculated VERB O
measures NOUN O
of ADP O
accessibility NOUN O
to ADP O
health NOUN O
facilities NOUN O
, PUNCT O
including VERB O
minimum ADJ O
distance NOUN O
from ADP O
the DET O
the DET O
geographic ADJ O
centers NOUN O
of ADP O
each DET O
block NOUN O
group NOUN O
to ADP O
hospitals NOUN O
[ PUNCT O
31 NUM O
] PUNCT O
, PUNCT O
pharmacies NOUN O
[ PUNCT O
31 NUM O
] PUNCT O
, PUNCT O
federally ADV B-LF
qualified ADJ I-LF
health NOUN I-LF
centers NOUN I-LF
( PUNCT O
FQHCs PROPN B-AC
) PUNCT O
[ PUNCT O
31 NUM O
] PUNCT O
, PUNCT O
buprenorphine NOUN O
prescribing VERB O
physicians NOUN O
, PUNCT O
and CCONJ O
Substance PROPN B-LF
Abuse PROPN I-LF
and CCONJ I-LF
Mental PROPN I-LF
Health PROPN I-LF
Services PROPN I-LF
Administration PROPN I-LF
( PUNCT O
SAMHSA PROPN B-AC
) PUNCT O
Opioid PROPN B-LF
Treatment PROPN I-LF
Programs PROPN I-LF
( PUNCT O
OTPs PROPN B-AC
) PUNCT O
[ PUNCT O
32 NUM O
] PUNCT O
; PUNCT O
and CCONJ O
the DET O
distance NOUN O
to ADP O
the DET O
closest ADJ O
fire NOUN O
department NOUN O
[ PUNCT O
33 NUM O
] PUNCT O
. PUNCT O

Briefly ADV O
, PUNCT O
we PRON O
acquired VERB O
the DET O
15N NUM O
backbone NOUN O
relaxation NOUN O
data NOUN O
T1 NOUN O
, PUNCT O
T2 NOUN O
, PUNCT O
and CCONJ O
[ X O
1H]-15N NOUN O
steady ADJ O
- PUNCT O
state NOUN O
heteronuclear ADJ O
Nuclear PROPN O
Overhauser PROPN O
Effect PROPN O
( PUNCT O
hNOE PROPN B-AC
) PUNCT O
( PUNCT O
S2 PROPN O
Fig PROPN O
) PUNCT O
, PUNCT O
as ADP O
well ADV O
as ADP O
Carr PROPN B-LF
– PUNCT I-LF
Purcell PROPN I-LF
– PUNCT I-LF
Meiboom PROPN I-LF
– PUNCT I-LF
Gill PROPN I-LF
( PUNCT O
CPMG PROPN B-AC
) PUNCT O
relaxation NOUN O
dispersion NOUN O
data NOUN O
for ADP O
the DET O
NTD PROPN B-AC
at ADP O
50 NUM O
μM NOUN O
in ADP O
5 NUM O
mM NOUN O
sodium NOUN O
phosphate NOUN O
buffer NOUN O
( PUNCT O
pH NOUN O
6.0 NUM O
) PUNCT O
. PUNCT O

The DET O
top ADJ O
- PUNCT O
view NOUN O
of ADP O
MLA PROPN B-AC
( PUNCT O
Fig NOUN O
4A NOUN O
) PUNCT O
shows VERB O
that SCONJ O
the DET O
MLA PROPN B-AC
- PUNCT O
protein NOUN O
interactions NOUN O
mimic VERB O
the DET O
substrate NOUN O
analogue NOUN O
barbiturate NOUN B-LF
( PUNCT O
BAR)-protein NOUN B-AC
interactions NOUN O
at ADP O
A NOUN O
and CCONJ O
B NOUN O
carbonyl NOUN O
- PUNCT O
binding VERB O
sites NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
alt NOUN O
, PUNCT O
alternate ADJ O
days NOUN O
; PUNCT O
AUC0–24ss NOUN B-AC
= PUNCT O
area NOUN O
under ADP O
the DET O
concentration NOUN O
time NOUN O
curve NOUN O
from ADP O
0–24 NUM O
hours NOUN O
at ADP O
steady ADJ O
state NOUN O
; PUNCT O
MDR PROPN B-AC
- PUNCT B-AC
TB PROPN B-AC
, PUNCT O
multidrug NOUN B-LF
- PUNCT I-LF
resistant ADJ I-LF
tuberculosis NOUN I-LF
. PUNCT O

AD PROPN B-AC
- PUNCT B-AC
CM PROPN B-AC
, PUNCT O
Alzheimer PROPN B-LF
disease NOUN I-LF
– PUNCT I-LF
signature NOUN I-LF
cerebral ADJ I-LF
glucose NOUN I-LF
metabolism NOUN I-LF
; PUNCT O
AD PROPN B-AC
- PUNCT B-AC
CT PROPN B-AC
, PUNCT O
Alzheimer PROPN B-LF
disease NOUN I-LF
– PUNCT I-LF
signature NOUN I-LF
cortical ADJ I-LF
thickness NOUN I-LF
; PUNCT O
B NOUN O
, PUNCT O
unstandardized ADJ O
regression NOUN O
coefficient NOUN O
; PUNCT O
SD NOUN B-AC
, PUNCT O
standard ADJ B-LF
drink NOUN I-LF
; PUNCT O
SUVR NOUN B-AC
, PUNCT O
standardized ADJ B-LF
uptake NOUN I-LF
value NOUN I-LF
ratio NOUN I-LF
; PUNCT O
WMH PROPN B-AC
, PUNCT O
white ADJ B-LF
matter NOUN I-LF
hyperintensity NOUN I-LF
. PUNCT O

Studies NOUN O
on ADP O
patients NOUN O
and CCONJ O
lamin NOUN O
A NOUN O
/ SYM O
C NOUN O
– PUNCT O
deficient ADJ O
mouse NOUN O
models NOUN O
indicate VERB O
that SCONJ O
loss NOUN O
of ADP O
function NOUN O
of ADP O
lamin NOUN O
A NOUN O
/ SYM O
C NOUN O
proteins NOUN O
also ADV O
develops VERB O
some PRON O
of ADP O
the DET O
laminopathies NOUN O
, PUNCT O
including VERB O
muscular ADJ O
dystrophy NOUN O
, PUNCT O
dilated VERB B-LF
cardiomyopathy NOUN I-LF
( PUNCT O
DCM PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
Charcot PROPN B-LF
– PUNCT I-LF
Marie PROPN I-LF
– PUNCT I-LF
Tooth PROPN I-LF
disorder NOUN I-LF
, PUNCT I-LF
type NOUN I-LF
2 NUM I-LF
( PUNCT O
CMT2 NOUN B-AC
) PUNCT O
[ PUNCT O
14,23,24 NUM O
] PUNCT O
. PUNCT O

This DET O
study NOUN O
is AUX O
reported VERB O
as ADP O
per ADP O
the DET O
Consolidated PROPN B-LF
Health PROPN I-LF
Economic PROPN I-LF
Evaluation PROPN I-LF
Reporting PROPN I-LF
Standards PROPN I-LF
( PUNCT O
CHEERS PROPN B-AC
) PUNCT O
guideline NOUN O
( PUNCT O
S1 PROPN O
Checklist PROPN O
) PUNCT O
. PUNCT O

To PART O
determine VERB O
lineage NOUN O
- PUNCT O
specific ADJ O
genes NOUN O
, PUNCT O
we PRON O
first ADV O
extracted VERB O
genes NOUN O
that DET O
are AUX O
differentially ADV O
expressed VERB O
between ADP O
that DET O
lineage NOUN O
and CCONJ O
at ADP O
least ADV O
one NUM O
of ADP O
the DET O
other ADJ O
2 NUM O
lineages NOUN O
( PUNCT O
fold ADJ O
change NOUN O
> SYM O
5 NUM O
, PUNCT O
false ADJ B-LF
discovery NOUN I-LF
rate NOUN I-LF
[ X O
FDR NOUN B-AC
] X O
= SYM O
0.01 NUM O
) PUNCT O
. PUNCT O

When SCONJ O
appropriate ADJ O
, PUNCT O
the DET O
following ADJ O
chemicals NOUN O
( PUNCT O
Applichem PROPN O
, PUNCT O
Darmstadt PROPN O
, PUNCT O
Germany PROPN O
, PUNCT O
and CCONJ O
Sigma PROPN O
- NOUN O
Aldrich PROPN O
) PUNCT O
were AUX O
added VERB O
to ADP O
the DET O
medium NOUN O
at ADP O
the DET O
indicated VERB O
final ADJ O
concentrations NOUN O
: PUNCT O
kanamycin NOUN O
( PUNCT O
50 NUM O
μg NOUN O
/ NOUN O
ml NOUN O
) PUNCT O
, PUNCT O
ampicillin NOUN O
( PUNCT O
100 NUM O
μg NOUN O
/ NOUN O
ml NOUN O
) PUNCT O
, PUNCT O
chloramphenicol NOUN O
( PUNCT O
30 NUM O
μg NOUN O
/ NOUN O
ml NOUN O
) PUNCT O
, PUNCT O
4′,6 NUM B-LF
- NOUN I-LF
diamidino-2 NOUN I-LF
- NOUN I-LF
phenylindole NOUN I-LF
( PUNCT O
DAPI PROPN B-AC
; PUNCT O
1 NUM O
μg NOUN O
/ NOUN O
ml NOUN O
) PUNCT O
, PUNCT O
IPTG NOUN B-AC
( PUNCT O
1–1,000 NUM O
μM NOUN O
) PUNCT O
, PUNCT O
glucose NOUN O
( PUNCT O
0.2 NUM O
% PUNCT O
) PUNCT O
, PUNCT O
L NOUN O
- NOUN O
arabinose NOUN O
( PUNCT O
0.1%–0.2 NUM O
% PUNCT O
) PUNCT O
, PUNCT O
and CCONJ O
glycerol NOUN O
( PUNCT O
0.2 NUM O
% PUNCT O
) PUNCT O
. PUNCT O

The DET O
first ADJ O
termed VERB O
Significance PROPN B-LF
Testing PROPN I-LF
for ADP I-LF
Aberrant ADJ I-LF
Copy NOUN I-LF
number NOUN I-LF
( PUNCT O
STAC PROPN B-AC
) PUNCT O
algorithm NOUN O
, PUNCT O
and CCONJ O
the DET O
second ADJ O
is AUX O
a DET O
systematic ADJ O
method NOUN O
termed VERB O
Genomic PROPN B-LF
Identification PROPN I-LF
of ADP I-LF
Significant PROPN I-LF
Targets PROPN I-LF
in ADP I-LF
Cancer PROPN I-LF
( PUNCT O
GISTIC PROPN B-AC
) PUNCT O
o PART O
identify VERB O
biologically ADV O
significant ADJ O
copy NOUN O
number NOUN O
aberrations NOUN O
in ADP O
these DET O
samples NOUN O
. PUNCT O

BW PROPN B-AC
body NOUN B-LF
weight NOUN I-LF
; PUNCT O
FPG PROPN O
Fasting NOUN O
plasma NOUN O
glucose NOUN O
; PUNCT O
IPGTT PROPN B-AC
intraperitoneal ADJ B-LF
glucose NOUN I-LF
tolerance NOUN I-LF
test NOUN I-LF
; PUNCT O
ITT PROPN B-AC
insulin NOUN B-LF
tolerance NOUN I-LF
test NOUN I-LF
; PUNCT O
TG NOUN B-AC
triglyceride NOUN B-LF
; PUNCT O
ALT PROPN B-AC
Alanine PROPN B-LF
Aminotransferase NOUN I-LF
. PUNCT O

Values NOUN O
represent VERB O
median NOUN O
( PUNCT O
IQR PROPN O
) PUNCT O
. PUNCT O
INR NOUN B-AC
: PUNCT O
international ADJ B-LF
normalized VERB I-LF
ratio NOUN I-LF
, PUNCT O
aPTT NOUN B-AC
: PUNCT O
activated VERB B-LF
partial ADJ I-LF
thromboplastin NOUN I-LF
time NOUN I-LF
. PUNCT O

The DET O
lack NOUN O
of ADP O
unbiased ADJ O
global ADJ O
data NOUN O
that PRON O
adequately ADV O
includes VERB O
young ADJ O
adults NOUN O
in ADP O
urban ADJ O
slum NOUN O
settings NOUN O
who PRON O
are AUX O
out ADP O
- PUNCT O
of ADP O
- PUNCT O
school NOUN O
, PUNCT O
away ADV O
from ADP O
home NOUN O
, PUNCT O
and CCONJ O
disconnected VERB O
from ADP O
health NOUN O
facilities NOUN O
has AUX O
led VERB O
to PART O
increased VERB O
interest NOUN O
in ADP O
respondent NOUN B-LF
- PUNCT I-LF
driven VERB I-LF
sampling NOUN I-LF
( PUNCT O
RDS PROPN B-AC
) PUNCT O
to PART O
reach VERB O
a DET O
larger ADJ O
number NOUN O
of ADP O
impoverished ADJ O
and CCONJ O
underserved ADJ O
youth NOUN O
who PRON O
are AUX O
often ADV O
missed VERB O
using VERB O
more ADV O
traditional ADJ O
sampling NOUN O
methodologies NOUN O
[ PUNCT O
14 NUM O
] PUNCT O
. PUNCT O

cDNA NOUN B-AC
encoding VERB O
candidate NOUN O
proteins NOUN O
identified VERB O
by ADP O
liquid NOUN B-LF
chromatography NOUN I-LF
– PUNCT I-LF
mass NOUN I-LF
spectrometry NOUN I-LF
( PUNCT O
LC PROPN B-AC
– PUNCT B-AC
MS PROPN B-AC
) PUNCT O
analysis NOUN O
( PUNCT O
described VERB O
elsewhere ADV O
[ X O
8 NUM O
] PUNCT O
) PUNCT O
were AUX O
cloned VERB O
from ADP O
a DET O
murine ADJ O
brain NOUN O
cDNA NOUN B-AC
library NOUN O
. PUNCT O
cDNA NOUN B-AC
constructs NOUN O
were AUX O
inserted VERB O
into ADP O
the DET O
pGEX6P-3 PROPN O
plasmid NOUN O
( PUNCT O
GE PROPN O
Healthcare PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
and CCONJ O
expressed VERB O
as ADP O
GST PROPN B-AC
- PUNCT O
fusion NOUN O
proteins NOUN O
in ADP O
High ADJ O
- PUNCT O
efficiency NOUN O
BL21(DE3 PROPN O
) PUNCT O
Competent PROPN O
Cell PROPN O
( PUNCT O
GMbiolab PROPN O
, PUNCT O
Taiwan PROPN O
) PUNCT O
. PUNCT O

The DET O
measures NOUN O
of ADP O
variation NOUN O
( PUNCT O
random NOUN O
- ADJ O
effects NOUN O
) PUNCT O
were AUX O
reported VERB O
using VERB O
Intra ADJ O
- ADJ O
cluster NOUN O
correlation NOUN O
( PUNCT O
ICC PROPN B-AC
) PUNCT O
, PUNCT O
Median ADJ B-LF
Odds NOUN I-LF
Ratio NOUN I-LF
( PUNCT O
MOR PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
Proportional PROPN B-LF
Change PROPN I-LF
in ADP I-LF
Variance PROPN I-LF
( PUNCT O
PCV PROPN B-AC
) PUNCT O
. PUNCT O
ICC PROPN B-AC
was AUX O
used VERB O
to PART O
explain VERB O
cluster NOUN O
variation NOUN O
while SCONJ O
MOR PROPN B-AC
is AUX O
a DET O
measure NOUN O
of ADP O
unexplained ADJ O
cluster NOUN O
heterogeneity NOUN O
[ PUNCT O
27 NUM O
] PUNCT O
. PUNCT O

However ADV O
there PRON O
is VERB O
an DET O
attractive ADJ O
, PUNCT O
facile ADJ O
method NOUN O
for ADP O
functionalising VERB O
titanium NOUN O
devices NOUN O
; PUNCT O
the DET O
use NOUN O
of ADP O
alkane NOUN B-LF
phosphonic ADJ I-LF
acids NOUN I-LF
( PUNCT O
APAs PROPN B-AC
) PUNCT O
which PRON O
have VERB O
a DET O
natural ADJ O
, PUNCT O
high ADJ O
affinity NOUN O
for ADP O
metal NOUN O
oxides NOUN O
[ X O
12 NUM O
] X O
including VERB O
titania NOUN O
( PUNCT O
TiO2 NOUN O
) PUNCT O
, PUNCT O
the DET O
natural ADJ O
coating NOUN O
of ADP O
titanium NOUN O
. PUNCT O

Overall ADV O
, PUNCT O
HCPs NOUN B-AC
were AUX O
knowledgeable ADJ O
about ADP O
STIs NOUN B-AC
, PUNCT O
saw VERB O
STIs NOUN B-AC
as ADP O
a DET O
priority NOUN O
, PUNCT O
reported VERB O
high ADJ O
STI NOUN B-AC
co NOUN O
- NOUN O
infection NOUN O
amongst ADP O
people NOUN B-LF
living VERB I-LF
with ADP I-LF
HIV PROPN I-LF
( PUNCT O
PLHIV PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
believed VERB O
STIs NOUN B-AC
in ADP O
PLHIV PROPN B-AC
facilitate VERB O
HIV PROPN O
transmission NOUN O
. PUNCT O

MPAS PROPN B-AC
Maternal PROPN B-LF
Postnatal ADJ I-LF
Attachment PROPN I-LF
Scale PROPN I-LF

This DET O
family NOUN O
of ADP O
promiscuous ADJ O
enzymes NOUN O
, PUNCT O
the DET O
wax NOUN O
ester NOUN O
synthase NOUN O
/ SYM O
acyl NOUN O
- PUNCT O
CoA PROPN O
: NOUN O
diacylglycerol NOUN B-LF
acyltransferases NOUN O
( PUNCT O
WS PROPN B-AC
/ SYM B-AC
DGAT PROPN B-AC
) PUNCT O
, PUNCT O
mediates VERB O
both CCONJ O
WE PROPN O
and CCONJ O
TAG PROPN B-AC
formation NOUN O
from ADP O
long ADJ O
- PUNCT O
chain NOUN O
acyl NOUN O
- PUNCT O
coenzyme NOUN O
A NOUN O
( PUNCT O
CoA PROPN O
) PUNCT O
molecules NOUN O
as ADP O
acyl NOUN O
donors NOUN O
and CCONJ O
long ADJ O
- PUNCT O
chain NOUN O
fatty ADJ O
alcohols NOUN O
or CCONJ O
diacylglycerols NOUN B-LF
( PUNCT O
DAGs PROPN B-AC
) PUNCT O
as ADP O
respective ADJ O
acyl NOUN O
acceptors NOUN O
in ADP O
bacteria NOUN O
. PUNCT O

The DET O
basic ADJ O
properties NOUN O
of ADP O
SSA PROPN B-AC
have AUX O
been AUX O
studied VERB O
in ADP O
great ADJ O
detail NOUN O
not PART O
only ADV O
in ADP O
A1 PROPN B-AC
but CCONJ O
also ADV O
in ADP O
the DET O
subcortical ADJ O
inferior ADJ B-LF
colliculus NOUN I-LF
( PUNCT O
IC PROPN B-AC
) PUNCT O
[ X O
14–16 NUM O
] PUNCT O
and CCONJ O
medial ADJ B-LF
geniculate ADJ I-LF
body NOUN I-LF
( PUNCT O
MGB PROPN B-AC
) PUNCT O
[ X O
17,18 NUM O
] PUNCT O
. PUNCT O

This DET O
study NOUN O
is AUX O
reported VERB O
per ADP O
the DET O
Consolidated PROPN B-LF
Standards PROPN I-LF
of ADP I-LF
Reporting PROPN I-LF
Trials PROPN I-LF
( PUNCT O
CONSORT PROPN B-AC
) PUNCT O
guideline NOUN O
( PUNCT O
S1 PROPN O
CONSORT PROPN B-AC
Checklist PROPN O
) PUNCT O
. PUNCT O

ART PROPN B-AC
, PUNCT O
antiretroviral ADJ B-LF
therapy NOUN I-LF
; PUNCT O
CHiP PROPN B-AC
, PUNCT O
community NOUN B-LF
HIV PROPN I-LF
- PUNCT I-LF
care NOUN I-LF
provider NOUN I-LF
. PUNCT O

The DET O
laboratory NOUN O
evaluation NOUN O
included VERB O
total ADJ B-LF
cholesterol NOUN I-LF
( PUNCT O
TC PROPN B-AC
) PUNCT O
, PUNCT O
triglycerides NOUN B-LF
( PUNCT O
TG NOUN B-AC
) PUNCT O
, PUNCT O
low ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
( PUNCT O
LDL PROPN B-AC
) PUNCT O
cholesterol NOUN O
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
( PUNCT O
HDL PROPN B-AC
) PUNCT O
cholesterol NOUN O
, PUNCT O
C NOUN B-LF
- PUNCT I-LF
reactive ADJ I-LF
protein NOUN I-LF
( PUNCT O
CRP PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
fasting VERB O
glucose NOUN O
and CCONJ O
haemoglobin NOUN B-LF
A1c NOUN I-LF
( PUNCT O
HbA1c NOUN B-AC
) PUNCT O
levels NOUN O
. PUNCT O

Access NOUN O
to ADP O
antiretroviral ADJ B-LF
therapy NOUN I-LF
has AUX O
increased VERB O
rapidly ADV O
since SCONJ O
2005 NUM O
and CCONJ O
globally ADV O
an DET O
estimated VERB O
21.7 NUM O
million NUM O
people NOUN O
are AUX O
receiving VERB O
antiretroviral ADJ B-LF
therapy NOUN I-LF
( PUNCT O
ART PROPN B-AC
) PUNCT O
in ADP O
which PRON O
the DET O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT O
WHO PROPN B-AC
) PUNCT O
African PROPN O
Region PROPN O
accounts VERB O
60 NUM O
% NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

Dulbecco PROPN O
’s PART O
Modified PROPN O
Eagle PROPN O
’s PART O
Medium PROPN O
( PUNCT O
DMEM PROPN B-AC
) PUNCT O
was AUX O
purchased VERB O
from ADP O
Nutricell PROPN O
( PUNCT O
Campinas PROPN O
, PUNCT O
SP PROPN O
, PUNCT O
Brazil PROPN O
) PUNCT O
and CCONJ O
3-(4,5 NUM B-LF
- PUNCT I-LF
dimethylthiazol-2 NOUN I-LF
- PUNCT I-LF
yl)-2,5 NUM I-LF
- PUNCT I-LF
diphenyltetrazolium NOUN I-LF
bromide NOUN I-LF
( PUNCT O
MTT PROPN B-AC
) PUNCT O
was AUX O
from ADP O
Calbiochem PROPN O
Corp. PROPN O
( PUNCT O
La PROPN O
Jolla PROPN O
, PUNCT O
CA PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
. PUNCT O

The DET O
primary ADJ O
endpoint NOUN O
was AUX O
the DET O
RFS PROPN B-AC
, PUNCT O
the DET O
exposure NOUN O
variable NOUN O
was AUX O
the DET O
PMI PROPN B-AC
, PUNCT O
and CCONJ O
the DET O
overall ADJ B-LF
survival NOUN I-LF
( PUNCT O
OS PROPN B-AC
) PUNCT O
and CCONJ O
cancer NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
survival NOUN I-LF
( PUNCT O
CSS PROPN B-AC
) PUNCT O
were AUX O
secondary ADJ O
endpoints NOUN O
. PUNCT O

CTD PROPN B-AC
, PUNCT O
C NOUN B-LF
- PUNCT I-LF
terminal ADJ I-LF
domain NOUN I-LF
; PUNCT O
HNH NOUN B-AC
, PUNCT O
HNH NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
nuclease NOUN I-LF
; PUNCT O
NUC PROPN B-AC
lobe NOUN B-AC
, PUNCT O
nuclease NOUN B-LF
lobe NOUN I-LF
; PUNCT O
PAM PROPN B-AC
, PUNCT O
protospacer NOUN B-LF
adjacent ADJ I-LF
motif NOUN I-LF
; PUNCT O
REC PROPN B-AC
lobe NOUN B-AC
, PUNCT O
α ADJ B-LF
- PUNCT I-LF
helical ADJ I-LF
recognition NOUN I-LF
lobe NOUN I-LF
; PUNCT O
RuvC NOUN B-AC
, PUNCT O
RuvC NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
nuclease NOUN I-LF
; PUNCT O
sgRNA NOUN B-AC
, PUNCT O
single ADJ B-LF
- PUNCT I-LF
guide NOUN I-LF
RNA NOUN I-LF
; PUNCT O
SpCas9 PROPN B-AC
, PUNCT O
Streptococcus PROPN B-LF
pyogenes NOUN I-LF
Cas9 PROPN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild NOUN B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

The DET O
auditory ADJ B-LF
nerves NOUN I-LF
( PUNCT O
AN PROPN B-AC
) PUNCT O
are AUX O
modeled VERB O
as ADP O
leaky ADJ O
integrate VERB O
- PUNCT O
and CCONJ O
- PUNCT O
fire VERB O
neurons NOUN O
with ADP O
stochastically ADV O
variable ADJ O
absolute ADJ O
and CCONJ O
relative ADJ O
refractory ADJ O
times NOUN O
, PUNCT O
latency NOUN O
and CCONJ O
jitter NOUN O
, PUNCT O
as ADP O
well ADV O
as ADP O
a DET O
neuronal ADJ O
membrane NOUN O
noise NOUN O
. PUNCT O

CVD NOUN B-AC
, PUNCT O
cardiovascular ADJ B-LF
disease NOUN I-LF
; PUNCT O
HR NOUN O
, PUNCT O
hazard NOUN O
ratio NOUN O
; PUNCT O
IR NOUN O
, PUNCT O
incidence NOUN O
rate NOUN O
. PUNCT O

TEM PROPN B-AC
, PUNCT O
transmission NOUN B-LF
electron NOUN I-LF
microscopy NOUN I-LF
; PUNCT O
Tf PROPN B-AC
- PUNCT B-AC
LPA PROPN B-AC
, PUNCT O
Top PROPN B-LF
- PUNCT I-LF
Fluor NOUN I-LF
lysophosphatidic NOUN I-LF
acid NOUN I-LF
. PUNCT O

Reliable ADJ O
estimates NOUN O
of ADP O
measures NOUN O
of ADP O
mortality NOUN O
from ADP O
severe ADJ B-LF
acute ADJ I-LF
respiratory ADJ I-LF
syndrome NOUN I-LF
coronavirus NOUN I-LF
2 NUM I-LF
( PUNCT O
SARS PROPN B-AC
- PUNCT B-AC
CoV-2 PROPN B-AC
) PUNCT O
infection NOUN O
are AUX O
needed VERB O
to PART O
understand VERB O
clinical ADJ O
prognosis NOUN O
, PUNCT O
to PART O
plan VERB O
healthcare NOUN O
capacity NOUN O
, PUNCT O
and CCONJ O
for ADP O
epidemic NOUN O
forecasting NOUN O
. PUNCT O

ESCC PROPN B-AC
, PUNCT O
esophageal ADJ B-LF
squamous ADJ I-LF
cell NOUN I-LF
carcinoma NOUN I-LF
; PUNCT O
HC PROPN O
, PUNCT O
healthy ADJ O
control NOUN O
; PUNCT O
HRA PROPN O
, PUNCT O
health NOUN O
risk NOUN O
appraisal NOUN O
; PUNCT O
HPSCC PROPN B-AC
, PUNCT O
hypopharyngeal ADJ B-LF
squamous ADJ I-LF
cell NOUN I-LF
carcinoma NOUN I-LF
; PUNCT O
SCC PROPN O
, PUNCT O
squamous ADJ O
cell NOUN O
carcinoma NOUN O
; PUNCT O
SD NOUN O
, PUNCT O
standard ADJ O
deviation NOUN O
. PUNCT O

TUN PROPN B-AC
and CCONJ O
EVN PROPN B-AC
are AUX O
both PRON O
involved ADJ O
in ADP O
protein NOUN O
N NOUN O
- PUNCT O
glycosylation NOUN O
in ADP O
the DET O
endoplasmic ADJ B-LF
reticulum NOUN I-LF
( PUNCT O
ER PROPN B-AC
) PUNCT O
and CCONJ O
encode VERB O
a DET O
putative ADJ O
uridine NOUN B-LF
diphosphate NOUN I-LF
( PUNCT O
UDP)-glycosyltransferase NOUN B-AC
superfamily NOUN O
protein NOUN O
and CCONJ O
a DET O
dolichol NOUN O
kinase NOUN O
, PUNCT O
respectively ADV O
. PUNCT O

Statistical ADJ O
heterogeneity NOUN B-LF
( PUNCT O
I2 NOUN B-AC
) PUNCT O
. PUNCT O

IL6 PROPN B-AC
makes VERB O
direct ADJ O
interaction NOUN O
with ADP O
NFkB PROPN O
( PUNCT O
complex NOUN O
) PUNCT O
, PUNCT O
P38 PROPN O
MAPK PROPN O
, PUNCT O
and CCONJ O
TNF PROPN O
. PUNCT O
Akt PROPN O
/ SYM O
PI3 PROPN O
K PROPN O
was AUX O
also ADV O
reported VERB O
in ADP O
our PRON O
previous ADJ O
findings NOUN O
, PUNCT O
for ADP O
which PRON O
it PRON O
was AUX O
an DET O
important ADJ O
member NOUN O
of ADP O
a DET O
network NOUN O
formed VERB O
by ADP O
genes NOUN O
of ADP O
metastatic ADJ B-LF
clear ADJ I-LF
cell NOUN I-LF
renal ADJ I-LF
cell NOUN I-LF
carcinoma NOUN I-LF
( PUNCT O
mccRCC PROPN B-AC
) PUNCT O
cell NOUN O
line NOUN O
Caki-1 PROPN O
[ PUNCT O
97 NUM O
] PUNCT O
. PUNCT O

Systemic ADJ O
inflammation NOUN O
is AUX O
often ADV O
reflected VERB O
by ADP O
increased VERB O
circulating VERB O
C NOUN B-LF
- PUNCT I-LF
reactive ADJ I-LF
protein NOUN I-LF
( PUNCT O
CRP PROPN B-AC
) PUNCT O
levels NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
AF PROPN B-AC
, PUNCT O
atrial ADJ B-LF
fibrillation NOUN I-LF
; PUNCT O
ECG PROPN B-AC
, PUNCT O
electrocardiogram NOUN B-LF
. PUNCT O

Abbreviation NOUN O
: PUNCT O
sBP NOUN B-AC
, PUNCT O
systolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
. PUNCT O

It PRON O
is AUX O
therefore ADV O
liable ADJ O
to PART O
capture VERB O
cases NOUN O
of ADP O
chronic ADJ B-LF
kidney NOUN I-LF
disease NOUN I-LF
( PUNCT O
CKD PROPN B-AC
) PUNCT O
with ADP O
relatively ADV O
mild ADJ O
creatinine NOUN O
elevations NOUN O
. PUNCT O

Further ADJ O
p53 NOUN O
epigenetic ADJ O
profiling NOUN O
was AUX O
done VERB O
by ADP O
Methylation NOUN B-LF
specific ADJ I-LF
PCR NOUN I-LF
( PUNCT O
MS PROPN B-AC
- PUNCT B-AC
PCR NOUN B-AC
) PUNCT O
and CCONJ O
western ADJ O
blotting NOUN O
by ADP O
using VERB O
p53 NOUN O
acetylation NOUN O
specific ADJ O
antibodies NOUN O
. PUNCT O

Weiner PROPN O
, PUNCT O
MD PROPN O
. PUNCT O
The DET O
primary ADJ O
goal NOUN O
of ADP O
ADNI PROPN B-AC
has AUX O
been AUX O
to ADP O
test VERB O
whether SCONJ O
serial ADJ O
magnetic ADJ B-LF
resonance NOUN I-LF
imaging NOUN I-LF
( PUNCT O
MRI PROPN B-AC
) PUNCT O
, PUNCT O
positron NOUN B-LF
emission NOUN I-LF
tomography NOUN I-LF
( PUNCT O
PET PROPN B-AC
) PUNCT O
, PUNCT O
other ADJ O
biological ADJ O
markers NOUN O
, PUNCT O
and CCONJ O
clinical ADJ O
and CCONJ O
neuropsychological ADJ O
assessment NOUN O
can AUX O
be AUX O
combined VERB O
to ADP O
measure VERB O
the DET O
progression NOUN O
of ADP O
mild ADJ B-LF
cognitive ADJ I-LF
impairment NOUN I-LF
( PUNCT O
MCI PROPN B-AC
) PUNCT O
and CCONJ O
early ADJ O
Alzheimer PROPN B-LF
’s PART I-LF
disease NOUN I-LF
( PUNCT O
AD PROPN B-AC
) PUNCT O
. PUNCT O
For ADP O
up ADP O
- PUNCT O
to ADP O
- PUNCT O
date NOUN O
information NOUN O
, PUNCT O
see VERB O
www.adni-info.org X O
. PUNCT O

England PROPN O
has VERB O
a DET O
national ADJ O
HIV PROPN B-LF
self NOUN I-LF
- PUNCT I-LF
sampling VERB I-LF
( PUNCT O
HIVSS PROPN B-AC
) PUNCT O
service NOUN O
, PUNCT O
where SCONJ O
an DET O
individual NOUN O
takes VERB O
a DET O
sample NOUN O
which PRON O
they PRON O
then ADV O
post VERB O
back ADV O
to ADP O
the DET O
laboratory NOUN O
where SCONJ O
it PRON O
is AUX O
processed VERB O
and CCONJ O
the DET O
patient NOUN O
is AUX O
contacted VERB O
with ADP O
the DET O
result NOUN O
[ X O
8 NUM O
, PUNCT O
9 NUM O
] PUNCT O
. PUNCT O

EGFR PROPN B-AC
: PUNCT O
epidermal ADJ B-LF
growth NOUN I-LF
factor NOUN I-LF
receptor NOUN I-LF
; PUNCT O
ICER PROPN B-AC
: PUNCT O
incremental ADJ B-LF
cost NOUN I-LF
- PUNCT I-LF
effectiveness NOUN I-LF
ratio NOUN I-LF
; PUNCT O
QALE PROPN B-AC
: PUNCT O
quality NOUN B-LF
- PUNCT I-LF
adjusted VERB I-LF
life NOUN I-LF
expectancy NOUN I-LF
; PUNCT O
QALY PROPN B-AC
: PUNCT O
quality NOUN B-LF
- PUNCT I-LF
adjusted VERB I-LF
life NOUN I-LF
year NOUN I-LF
; PUNCT O
TKI PROPN B-AC
: PUNCT O
tyrosine NOUN B-LF
kinase NOUN I-LF
inhibitor NOUN I-LF

Alb NOUN O
, PUNCT O
albumin NOUN O
; PUNCT O
APOA2 PROPN B-AC
, PUNCT O
apolipoprotein NOUN B-LF
A2 PROPN I-LF
; PUNCT O
Cont PROPN O
, PUNCT O
control NOUN O
; PUNCT O
E NOUN B-AC
- PUNCT B-AC
cad NOUN B-AC
, PUNCT O
E NOUN B-LF
- PUNCT I-LF
cadherin NOUN I-LF
; PUNCT O
EF1 PROPN B-AC
, PUNCT O
Human NOUN B-LF
elongation NOUN I-LF
factor-1 NOUN I-LF
alpha NOUN I-LF
promoter NOUN I-LF
; PUNCT O
FGF7 NOUN O
, PUNCT O
fibroblast NOUN B-LF
growth NOUN I-LF
factor NOUN I-LF
7 NUM I-LF
; PUNCT O
FGFR2 PROPN O
, PUNCT O
fibroblast NOUN O
growth NOUN O
factor NOUN O
receptor NOUN O
2 NUM O
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent NOUN I-LF
protein NOUN I-LF
; PUNCT O
HNF4α PROPN B-AC
, PUNCT O
hepatocyte NOUN B-LF
nuclear ADJ I-LF
factor NOUN I-LF
4 NUM I-LF
- PUNCT I-LF
alpha NOUN I-LF
; PUNCT O
IRS2 NOUN O
, PUNCT O
insulin NOUN B-LF
receptor NOUN I-LF
substrate NOUN I-LF
2 NUM I-LF
; PUNCT O
Lenti PROPN B-AC
- PUNCT B-AC
mIrs2 PROPN B-AC
, PUNCT O
murine NOUN B-LF
Irs2 PROPN I-LF
transgene NOUN I-LF
not PART I-LF
targeted VERB I-LF
by ADP I-LF
human ADJ I-LF
- PUNCT I-LF
gene NOUN I-LF
– PUNCT I-LF
silencing VERB I-LF
construct NOUN I-LF
; PUNCT O
mRNA NOUN B-AC
, PUNCT O
messenger NOUN B-LF
RNA NOUN I-LF
; PUNCT O
pAPOA2 PROPN B-AC
, PUNCT O
human ADJ O
APOA2 PROPN B-LF
promoter NOUN I-LF
; PUNCT O
pIRS2 PROPN B-AC
, PUNCT O
IRS2 NOUN B-LF
promoter NOUN I-LF
; PUNCT O
rFgf7 NOUN B-AC
, PUNCT O
recombinant ADJ B-LF
Fgf7 NOUN I-LF
; PUNCT O
rhFGF7 PROPN B-AC
, PUNCT O
recombinant ADJ B-LF
human ADJ I-LF
FGF7 NOUN I-LF
; PUNCT O
RT NOUN B-AC
- PUNCT B-AC
qPCR PROPN B-AC
, PUNCT O
reverse ADJ B-LF
transcriptase NOUN I-LF
- PUNCT I-LF
quantitative ADJ I-LF
PCR NOUN I-LF
; PUNCT O
RU PROPN B-AC
, PUNCT O
relative ADJ B-LF
unit NOUN I-LF
; PUNCT O
sh NOUN O
- PUNCT O
IRS2 NOUN O
, PUNCT O
shRNA NOUN B-AC
- PUNCT O
targeting VERB O
IRS2 NOUN O
; PUNCT O
sh NOUN B-AC
- PUNCT B-AC
luc NOUN B-AC
, PUNCT O
control NOUN B-LF
luciferase NOUN I-LF
; PUNCT O
shRNA NOUN B-AC
, PUNCT O
short ADJ B-LF
hairpin NOUN I-LF
RNA NOUN I-LF
; PUNCT O
sh NOUN O
- PUNCT O
scram NOUN O
, PUNCT O
scrambled ADJ O
shRNA NOUN B-AC
. PUNCT O

In ADP O
segments NOUN O
of ADP O
the DET O
thoracic ADJ O
aorta NOUN O
and CCONJ O
femoral ADJ O
artery NOUN O
contracted VERB O
with ADP O
256 NUM O
nM NOUN O
endothelin-1 NOUN O
, PUNCT O
the DET O
relaxing VERB O
effects NOUN O
of ADP O
Ach PROPN B-AC
were AUX O
reversed VERB O
by ADP O
100 NUM O
μM NOUN O
L NOUN B-LF
- PUNCT I-LF
NG NOUN I-LF
- PUNCT I-LF
nitro NOUN I-LF
arginine NOUN I-LF
methyl NOUN I-LF
ester NOUN I-LF
( PUNCT O
L NOUN B-AC
- PUNCT B-AC
NAME PROPN B-AC
) PUNCT O
( PUNCT O
a DET O
pharmacological ADJ O
inhibitor NOUN O
of ADP O
NOSs PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
this PRON O
did AUX O
not PART O
differ VERB O
significantly ADV O
between ADP O
preparations NOUN O
of ADP O
KI PROPN B-AC
and CCONJ O
WT PROPN B-AC
mice NOUN O
( PUNCT O
S5 PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

In ADP O
Ontario PROPN O
, PUNCT O
it PRON O
is AUX O
mandatory ADJ O
for ADP O
all DET O
long ADJ O
- PUNCT O
stay NOUN O
home NOUN O
care NOUN O
clients NOUN O
to PART O
be AUX O
assessed VERB O
with ADP O
a DET O
comprehensive ADJ O
clinical ADJ O
assessment NOUN O
tool NOUN O
, PUNCT O
the DET O
Resident PROPN B-LF
Assessment PROPN I-LF
Instrument PROPN I-LF
for ADP I-LF
Home PROPN I-LF
Care PROPN I-LF
( PUNCT O
RAI PROPN B-AC
- PUNCT B-AC
HC PROPN B-AC
) PUNCT O
, PUNCT O
on ADP O
a DET O
semiannual ADJ O
basis NOUN O
. PUNCT O

SCA3 PROPN B-AC
is AUX O
caused VERB O
by ADP O
an DET O
unstable ADJ O
cytosine NOUN B-LF
- PUNCT I-LF
adenine NOUN I-LF
- PUNCT I-LF
guanine NOUN I-LF
( PUNCT O
CAG PROPN B-AC
) PUNCT O
trinucleotide NOUN O
expansion NOUN O
mutation NOUN O
in ADP O
the DET O
ATXN3 PROPN O
gene NOUN O
leading VERB O
to ADP O
an DET O
expanded VERB O
polyQ NOUN O
tract NOUN O
within ADP O
the DET O
ataxin-3 NOUN B-LF
( PUNCT O
ATX-3 PROPN B-AC
) PUNCT O
protein NOUN O
[ PUNCT O
4 NUM O
] PUNCT O
. PUNCT O

Information NOUN O
in ADP O
the DET O
OHIP PROPN B-AC
Database PROPN O
is AUX O
recorded VERB O
using VERB O
physician NOUN O
billing NOUN O
claims NOUN O
; PUNCT O
information NOUN O
in ADP O
hospital NOUN O
databases NOUN O
is AUX O
recorded VERB O
using VERB O
the DET O
Canadian PROPN O
Coding PROPN O
Standards PROPN O
for ADP O
the DET O
International PROPN B-LF
Statistical PROPN I-LF
Classification PROPN I-LF
of ADP I-LF
Diseases PROPN I-LF
and CCONJ I-LF
Related PROPN I-LF
Health PROPN I-LF
Problems PROPN I-LF
, PUNCT O
10th ADJ O
revision NOUN O
( PUNCT O
ICD-10 PROPN B-AC
) PUNCT O
or CCONJ O
Diagnostic PROPN B-LF
and CCONJ I-LF
Statistical PROPN I-LF
Manual PROPN I-LF
of ADP I-LF
Mental PROPN I-LF
Disorders PROPN I-LF
, PUNCT O
4th ADJ O
edition NOUN O
( PUNCT O
DSM PROPN B-AC
- PUNCT O
IV PROPN O
) PUNCT O
. PUNCT O
The DET O
information NOUN O
in ADP O
these DET O
databases NOUN O
has AUX O
been AUX O
shown VERB O
to PART O
be AUX O
complete ADJ O
and CCONJ O
reliable ADJ O
; PUNCT O
sociodemographic ADJ O
data NOUN O
, PUNCT O
physician NOUN O
billing NOUN O
claims NOUN O
, PUNCT O
and CCONJ O
primary ADJ O
diagnoses NOUN O
in ADP O
hospital NOUN O
data NOUN O
sets NOUN O
have VERB O
excellent ADJ O
completeness NOUN O
and CCONJ O
accuracy NOUN O
[ PUNCT O
19 NUM O
] PUNCT O
. PUNCT O

After ADP O
collecting VERB O
5ml NUM O
of ADP O
venous ADJ O
blood NOUN O
sample NOUN O
in ADP O
EDTA PROPN B-AC
tube NOUN O
from ADP O
each DET O
study NOUN O
participants NOUN O
, PUNCT O
CBC PROPN O
results NOUN O
which PRON O
include VERB O
RBC NOUN O
parameters NOUN O
( PUNCT O
RBC NOUN O
count NOUN O
, PUNCT O
Hgb NOUN B-AC
, PUNCT O
mean ADJ B-LF
cell NOUN I-LF
hemoglobin NOUN I-LF
( PUNCT O
MCH PROPN B-AC
) PUNCT O
, PUNCT O
mean ADJ B-LF
cell NOUN I-LF
hemoglobin NOUN I-LF
concentration NOUN I-LF
( PUNCT O
MCHC PROPN B-AC
) PUNCT O
and CCONJ O
mean ADJ B-LF
cell NOUN I-LF
volume NOUN I-LF
( PUNCT O
MCV PROPN B-AC
) PUNCT O
) PUNCT O
, PUNCT O
WBC NOUN O
parameters NOUN O
( PUNCT O
WBC NOUN O
count NOUN O
, PUNCT O
absolute ADJ O
neutrophil NOUN O
count NOUN O
, PUNCT O
neutrophil NOUN O
percentage NOUN O
, PUNCT O
lymphocyte NOUN O
count NOUN O
, PUNCT O
lymphocyte NOUN O
percentage NOUN O
, PUNCT O
mixed ADJ O
count NOUN O
that PRON O
encompasses VERB O
eosinophil ADJ O
, PUNCT O
basophil ADJ O
and CCONJ O
monocyte NOUN O
and CCONJ O
mixed ADJ O
cell NOUN O
percentage NOUN O
) PUNCT O
and CCONJ O
platelet NOUN O
parameter NOUN O
( PUNCT O
platelet NOUN O
count NOUN O
and CCONJ O
mean ADJ O
platelet NOUN O
volume NOUN O
) PUNCT O
were AUX O
determined VERB O
using VERB O
sysmex PROPN O
KX21 PROPN O
hematology NOUN O
analyzer NOUN O
. PUNCT O

ART PROPN B-AC
, PUNCT O
assisted ADJ B-LF
reproductive ADJ I-LF
technology NOUN I-LF
; PUNCT O
SC PROPN B-AC
, PUNCT O
spontaneous ADJ B-LF
conception NOUN I-LF
. PUNCT O

Abbreviation NOUN O
: PUNCT O
IQR PROPN B-AC
, PUNCT O
interquartile ADJ B-LF
range NOUN I-LF

PPTs NOUN B-AC
: PUNCT O
pressure NOUN B-LF
pain NOUN I-LF
thresholds NOUN I-LF
; PUNCT O
TePs PROPN B-AC
: PUNCT O
tender NOUN B-LF
points NOUN I-LF
. PUNCT O

Here ADV O
, PUNCT O
we PRON O
explored VERB O
the DET O
role NOUN O
of ADP O
the DET O
hypoxia NOUN B-LF
- PUNCT I-LF
inducible ADJ I-LF
factors NOUN I-LF
( PUNCT O
HIFs NOUN B-AC
) PUNCT O
, PUNCT O
HIF-1α NOUN B-AC
( PUNCT O
encoded VERB O
by ADP O
HIF1A PROPN O
) PUNCT O
and CCONJ O
HIF-2α NOUN B-AC
( PUNCT O
encoded VERB O
by ADP O
EPAS1 PROPN O
) PUNCT O
. PUNCT O

SA NOUN B-AC
: PUNCT O
suture NOUN B-LF
anchor NOUN I-LF
, PUNCT O
TS NOUN B-AC
: PUNCT O
transosseous ADJ B-LF
suture NOUN I-LF
, PUNCT O
QTR NOUN B-AC
: PUNCT O
quadriceps NOUN B-LF
tendon NOUN I-LF
rupture NOUN I-LF
. PUNCT O

Compared VERB O
to PART O
baseline NOUN O
, NOUN O
women NOUN O
whose DET O
most ADV O
recent ADJ O
pregnancy NOUN O
occurred VERB O
during ADP O
the DET O
implementation NOUN O
period NOUN O
were AUX O
substantially ADV O
more ADV O
likely ADJ O
to PART O
receive VERB O
antenatal ADJ O
care NOUN O
( PUNCT O
71.8 NUM O
% NOUN O
versus ADP O
39.3 NUM O
% NOUN O
, NOUN O
prevalence NOUN B-LF
rate NOUN I-LF
ratio NOUN I-LF
[ PUNCT O
PRR NOUN B-AC
] PUNCT O
= X O
1.83 NUM O
[ PUNCT O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
( PUNCT O
CI NOUN B-AC
) PUNCT O
1.64–2.04 NUM O
] PUNCT O
) PUNCT O
and CCONJ O
specific ADJ O
interventions NOUN O
such ADJ O
as ADP O
urine NOUN O
testing NOUN O
( PUNCT O
42.4 NUM O
% NOUN O
versus ADP O
15.7 NUM O
% NOUN O
, NOUN O
PRR NOUN B-AC
= X O
2.69 NUM O
[ PUNCT O
95 NUM O
% NOUN O
CI NOUN B-AC
2.69–3.54 NUM O
] PUNCT O
) PUNCT O
, NOUN O
malaria NOUN O
screening NOUN O
( PUNCT O
55.9 NUM O
% NOUN O
versus ADP O
21.9 NUM O
% NOUN O
, NOUN O
PRR NOUN B-AC
= X O
2.88 NUM O
[ PUNCT O
95 NUM O
% NOUN O
CI NOUN B-AC
2.15–3.85 NUM O
] PUNCT O
) PUNCT O
, NOUN O
and CCONJ O
deworming NOUN O
( PUNCT O
58.2 NUM O
% NOUN O
versus ADP O
4.1 NUM O
% NOUN O
, NOUN O
PRR NOUN B-AC
= X O
14.18 NUM O
[ PUNCT O
95 NUM O
% NOUN O
CI NOUN B-AC
10.76–18.71 NUM O
] PUNCT O
. PUNCT O

One NUM O
of ADP O
the DET O
best ADJ O
surrogates NOUN O
of ADP O
chronic ADJ O
inflammation NOUN O
in ADP O
the DET O
pathogenesis NOUN O
of ADP O
tumor NOUN O
is AUX O
interleukin-6 NOUN B-LF
( PUNCT O
IL-6 PROPN B-AC
) PUNCT O
, PUNCT O
a DET O
pleiotropic ADJ O
inflammatory ADJ O
cytokine NOUN O
[ PUNCT O
8 NUM O
] PUNCT O
. PUNCT O

All DET O
reconstructed VERB O
sequences NOUN O
were AUX O
also ADV O
subjected VERB O
to ADP O
an DET O
alignment NOUN O
- PUNCT O
free ADJ O
approach NOUN O
using VERB O
feature NOUN B-LF
frequency NOUN I-LF
profiling NOUN I-LF
( PUNCT O
FFP PROPN B-AC
) PUNCT O
[ X O
53 NUM O
] PUNCT O
. PUNCT O

Clinical ADJ O
outcomes NOUN O
were AUX O
defined VERB O
as ADP O
rates NOUN O
of ADP O
admission NOUN O
to ADP O
intensive ADJ B-LF
care NOUN I-LF
unit NOUN I-LF
( PUNCT O
ICU PROPN B-AC
) PUNCT O
and CCONJ O
in ADP O
- PUNCT O
hospital NOUN O
mortality NOUN O
and CCONJ O
were AUX O
monitored VERB O
until ADP O
the DET O
10th ADJ O
June PROPN O
2020 NUM O
. PUNCT O

Apoptosis NOUN O
of ADP O
both PRON O
, PUNCT O
mitoNEET NOUN O
- PUNCT O
KD PROPN B-AC
and CCONJ O
control NOUN O
cells NOUN O
was AUX O
diminished VERB O
to ADP O
comparable ADJ O
levels NOUN O
by ADP O
using VERB O
the DET O
antioxidants NOUN O
Tiron PROPN O
and CCONJ O
glutathione NOUN B-LF
compound NOUN I-LF
glutathione NOUN I-LF
reduced VERB I-LF
ethyl NOUN I-LF
ester NOUN I-LF
( PUNCT O
GSH NOUN B-AC
- PUNCT B-AC
MEE PROPN B-AC
) PUNCT O
, PUNCT O
indicating VERB O
that SCONJ O
mitoNEET NOUN O
- PUNCT O
dependent ADJ O
apoptosis NOUN O
is AUX O
mediated VERB O
by ADP O
oxidative ADJ O
stress NOUN O
. PUNCT O

A DET O
milestone NOUN O
meta NOUN O
- NOUN O
analysis NOUN O
[ X O
11 X O
] X O
mentioned VERB O
the DET O
independent ADJ O
predictors NOUN O
of ADP O
CIN PROPN B-AC
included VERB O
chronic ADJ B-LF
kidney NOUN I-LF
disease NOUN I-LF
( PUNCT O
CKD PROPN B-AC
) PUNCT O
, PUNCT O
CKD PROPN B-AC
with ADP O
DM PROPN B-AC
, PUNCT O
and CCONJ O
use NOUN O
of ADP O
LOCM PROPN B-AC
. PUNCT O
However ADV O
, PUNCT O
CKD PROPN B-AC
with ADP O
DM PROPN B-AC
group NOUN O
had VERB O
a DET O
much ADV O
higher ADJ O
increase NOUN O
of ADP O
maximum ADJ O
serum NOUN B-LF
creatinine NOUN I-LF
( PUNCT O
SCr NOUN B-AC
) PUNCT O
, PUNCT O
than ADP O
CKD PROPN B-AC
without ADP O
DM PROPN B-AC
after ADP O
contrast NOUN O
exposure NOUN O
. PUNCT O

The DET O
mRNA NOUN O
expression NOUN O
of ADP O
the DET O
collagen NOUN B-LF
I NUM I-LF
, PUNCT O
collagen NOUN O
III NUM O
and CCONJ O
collagen NOUN O
VI NUM O
genes NOUN O
was AUX O
higher ADJ O
in ADP O
the DET O
diaphragm NOUN O
fibrogenic ADJ O
cells NOUN O
than ADP O
in ADP O
the DET O
quadriceps NOUN O
fibrogenic ADJ O
cells NOUN O
, PUNCT O
and CCONJ O
the DET O
mRNA NOUN O
expression NOUN O
of ADP O
the DET O
fibronectin NOUN O
gene NOUN O
was AUX O
similar ADJ O
( PUNCT O
Fig PROPN O
4C NUM O
) PUNCT O
. PUNCT O
Therefore ADV O
, PUNCT O
consistent ADJ O
with ADP O
more ADV O
severe ADJ O
fibrosis NOUN O
in ADP O
the DET O
ColI PROPN B-AC
- PROPN O
GFP PROPN O
/ SYM O
mdx5cv NOUN O
diaphragm NOUN O
, PUNCT O
the DET O
ColI PROPN B-AC
- PROPN O
GFP PROPN O
/ SYM O
mdx5cv NOUN O
diaphragm NOUN O
fibrogenic ADJ O
cells NOUN O
exert VERB O
a DET O
higher ADJ O
fibrogenic ADJ O
function NOUN O
than ADP O
the DET O
quadriceps NOUN O
fibrogenic ADJ O
cells NOUN O
despite SCONJ O
a DET O
low ADJ O
level NOUN O
of ADP O
α PROPN B-AC
- PROPN B-AC
SMA PROPN B-AC
expression NOUN O
by ADP O
the DET O
diaphragm NOUN O
fibrogenic ADJ O
cells NOUN O
. PUNCT O
α PROPN B-AC
- PROPN B-AC
SMA PROPN B-AC
is AUX O
not PART O
a DET O
marker NOUN O
for ADP O
the DET O
fibrogenic ADJ O
function NOUN O
of ADP O
fibrogenic ADJ O
cells NOUN O
in ADP O
dystrophic ADJ O
muscles NOUN O
. PUNCT O

Mouse ADJ O
IgG1 NOUN O
was AUX O
used VERB O
as ADP O
a DET O
control NOUN O
of ADP O
anti NOUN O
- PUNCT O
erbB1 NOUN O
. PUNCT O
Human ADJ O
fibroblasts NOUN O
and CCONJ O
human ADJ B-LF
umbilical ADJ I-LF
vein NOUN I-LF
endothelial ADJ I-LF
cells NOUN I-LF
( PUNCT O
HUVECs NOUN B-AC
) PUNCT O
were AUX O
cultured VERB O
in ADP O
96 NUM O
- PUNCT O
well NOUN O
plates NOUN O
. PUNCT O

Metabolomics NOUN O
technologies NOUN O
based VERB O
on ADP O
mass NOUN B-LF
spectrometry NOUN I-LF
( PUNCT O
MS PROPN B-AC
) PUNCT O
and CCONJ O
nuclear ADJ B-LF
magnetic ADJ I-LF
resonance NOUN I-LF
( PUNCT O
NMR PROPN B-AC
) PUNCT O
have AUX O
enabled VERB O
the DET O
systematic ADJ O
quantification NOUN O
of ADP O
hundreds NOUN O
of ADP O
metabolites NOUN O
( PUNCT O
the DET O
“ PUNCT O
metabolome NOUN O
” PUNCT O
) PUNCT O
from ADP O
a DET O
single ADJ O
biological ADJ O
sample NOUN O
. PUNCT O

Aspartate NOUN B-LF
aminotransferase NOUN I-LF
( PUNCT O
AST PROPN B-AC
) PUNCT O
and CCONJ O
alanine ADJ B-LF
aminotransferase NOUN I-LF
( PUNCT O
ALT PROPN B-AC
) PUNCT O
activities NOUN O
in ADP O
plasma NOUN O
were AUX O
determined VERB O
using VERB O
corresponding ADJ O
colorimetric ADJ O
assay NOUN O
kits NOUN O
supplied VERB O
by ADP O
Sigma PROPN O
- PUNCT O
Aldrich PROPN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
AFP PROPN B-AC
, PUNCT O
alpha NOUN B-LF
- PUNCT I-LF
fetoprotein NOUN I-LF
; PUNCT O
IQR PROPN O
, PUNCT O
interquartile ADJ O
range NOUN O
; PUNCT O
PEIT PROPN O
, PUNCT O
percutaneous ADJ O
ethanol NOUN O
injection NOUN O
therapy NOUN O
; PUNCT O
RFA PROPN O
, PUNCT O
radiofrequency ADJ O
ablation NOUN O
; PUNCT O
RT PROPN O
, PUNCT O
radiotherapy NOUN O
; PUNCT O
TACE PROPN O
, PUNCT O
transarterial ADJ O
chemoembolization NOUN O
. PUNCT O

Karyotype NOUN O
and CCONJ O
genome NOUN O
- PUNCT O
wide ADJ O
copy NOUN B-LF
number NOUN I-LF
variation NOUN I-LF
( PUNCT O
CNV PROPN B-AC
) PUNCT O
analyses NOUN O
demonstrated VERB O
that PRON O
genomic ADJ O
integrity NOUN O
was AUX O
maintained VERB O
in ADP O
YAP−/− NOUN B-AC
and CCONJ O
TAZ−/− NOUN B-AC
hESCs NOUN B-AC
after ADP O
more ADJ O
than ADP O
30 NUM O
passages NOUN O
( PUNCT O
Figs NOUN O
1F NOUN O
and CCONJ O
S1F NOUN O
) PUNCT O
. PUNCT O
Moreover ADV O
, PUNCT O
YAP−/− NOUN B-AC
and CCONJ O
TAZ−/− NOUN B-AC
hESCs NOUN B-AC
displayed VERB O
transcriptional ADJ O
profiles NOUN O
that PRON O
were AUX O
highly ADV O
similar ADJ O
to ADP O
wild ADJ B-LF
type NOUN I-LF
( PUNCT O
WT PROPN B-AC
) PUNCT O
hESCs NOUN B-AC
( PUNCT O
Fig NOUN O
1 NUM O
G NOUN O
) PUNCT O
. PUNCT O

HbA1c NOUN B-AC
, PUNCT O
hemoglobin NOUN B-LF
A1c NOUN I-LF
. PUNCT O

Figures NOUN O
for ADP O
the DET O
65 NUM O
+ NUM O
-y NOUN O
age NOUN O
group NOUN O
from ADP O
2004/2005 NUM O
onwards ADV O
were AUX O
taken VERB O
from ADP O
the DET O
Health PROPN B-LF
Protection PROPN I-LF
Agency PROPN I-LF
/ SYM I-LF
Department PROPN I-LF
of ADP I-LF
Health PROPN I-LF
( PUNCT O
HPA PROPN B-AC
/ SYM B-AC
DH PROPN B-AC
) PUNCT O
annual ADJ O
reports NOUN O
on ADP O
the DET O
influenza NOUN O
programme NOUN O
[ PUNCT O
18 NUM O
] PUNCT O
. PUNCT O

Then ADV O
, PUNCT O
heart NOUN B-LF
rate NOUN I-LF
( PUNCT O
HR NOUN B-AC
) PUNCT O
, PUNCT O
systolic ADJ O
arterial ADJ O
pressure NOUN O
( PUNCT O
SAP PROPN B-AC
) PUNCT O
, PUNCT O
diastolic ADJ B-LF
arterial ADJ I-LF
pressure NOUN I-LF
( PUNCT O
DAP PROPN B-AC
) PUNCT O
, PUNCT O
left ADJ B-LF
ventricular ADJ I-LF
systolic ADJ I-LF
pressure NOUN I-LF
( PUNCT O
LVSP PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
left ADJ B-LF
ventricular ADJ I-LF
end NOUN I-LF
- NOUN I-LF
diastolic ADJ I-LF
pressure NOUN I-LF
( PUNCT O
LVEDP PROPN B-AC
) PUNCT O
were AUX O
recorded VERB O
using VERB O
an DET O
Ultra PROPN O
- NOUN O
Miniature PROPN O
Pressure PROPN O
Catheter PROPN O
( PUNCT O
Scisense PROPN O
advancing VERB O
micro NOUN O
- NOUN O
sensor NOUN O
technology NOUN O
™ PUNCT O
, PUNCT O
USA PROPN O
/ SYM O
CAN PROPN O
) PUNCT O
under ADP O
mild ADJ O
anaesthesia NOUN O
( PUNCT O
1 NUM O
% NOUN O
isoflurane NOUN O
, PUNCT O
heart NOUN B-LF
rate NOUN I-LF
: PUNCT O
~500 NUM O
min–1 NOUN O
) PUNCT O
. PUNCT O

PSO NOUN B-AC
: PUNCT O
post NOUN B-LF
- PUNCT I-LF
outlier NOUN I-LF
; PUNCT O
N NOUN O
: PUNCT O
number NOUN O
of ADP O
included VERB O
studies NOUN O
; PUNCT O
n NOUN O
: PUNCT O
sample NOUN O
size NOUN O
; PUNCT O
Pc NOUN B-AC
: PUNCT O
Bonferroni NOUN O
- PUNCT O
corrected VERB O
P NOUN O
- PUNCT O
value NOUN O
; PUNCT O
Pci NOUN B-AC
: PUNCT O
Bonferroni NOUN B-LF
- PUNCT I-LF
corrected VERB I-LF
P NOUN I-LF
- PUNCT I-LF
value NOUN I-LF
for ADP I-LF
interaction NOUN I-LF
; PUNCT O
OR NOUN B-AC
: PUNCT O
odd ADJ O
ratio NOUN O
; PUNCT O
CI NOUN B-AC
: PUNCT O
confidence NOUN B-LF
interval NOUN I-LF

MSC PROPN B-AC
, PUNCT O
multi ADJ B-LF
- ADJ I-LF
tRNA ADJ I-LF
synthetase NOUN I-LF
complex NOUN I-LF
. PUNCT O

The DET O
objective NOUN O
of ADP O
this DET O
study NOUN O
was AUX O
to PART O
assess VERB O
the DET O
classification NOUN O
capability NOUN O
of ADP O
Breast PROPN B-LF
Imaging PROPN I-LF
Reporting PROPN I-LF
and CCONJ I-LF
Data PROPN I-LF
System PROPN I-LF
( PUNCT O
BI PROPN B-AC
- PUNCT B-AC
RADS PROPN B-AC
) PUNCT O
ultrasound NOUN O
feature NOUN O
descriptors NOUN O
targeting VERB O
established VERB O
commercial ADJ O
transcriptomic ADJ O
gene NOUN O
signatures NOUN O
that PRON O
guide VERB O
management NOUN O
of ADP O
breast NOUN O
cancer NOUN O
. PUNCT O

These DET O
findings NOUN O
support VERB O
the DET O
current ADJ O
World PROPN O
Health PROPN O
Organization/ PROPN O
United PROPN B-LF
Nations PROPN I-LF
Children PROPN I-LF
's PART I-LF
Emergency PROPN I-LF
Fund PROPN I-LF
( PUNCT O
UNICEF PROPN B-AC
) PUNCT O
system NOUN O
that PRON O
categorizes VERB O
shared ADJ O
sanitation NOUN O
as ADP O
unimproved ADJ O
. PUNCT O

Prior ADV O
to ADP O
stimulation NOUN O
, PUNCT O
cells NOUN O
were AUX O
washed VERB O
once ADV O
with ADP O
phosphate NOUN B-LF
- PUNCT I-LF
buffered VERB I-LF
saline NOUN I-LF
( PUNCT O
PBS PROPN B-AC
) PUNCT O
and CCONJ O
incubated VERB O
for ADP O
the DET O
indicated VERB O
time NOUN O
periods NOUN O
in ADP O
cell NOUN O
culture NOUN O
medium NOUN O
containing VERB O
the DET O
different ADJ O
agents NOUN O
at ADP O
the DET O
indicated VERB O
concentrations NOUN O
. PUNCT O

Body NOUN O
composition NOUN O
also ADV O
differed VERB O
, PUNCT O
with ADP O
dual ADJ B-LF
- NOUN I-LF
energy NOUN I-LF
X NOUN I-LF
- NOUN I-LF
ray NOUN I-LF
absorptiometry NOUN I-LF
( PUNCT O
DEXA PROPN B-AC
) PUNCT O
scans NOUN O
showing VERB O
a DET O
higher ADJ O
percent NOUN O
of ADP O
body NOUN O
fat NOUN O
in ADP O
Oct1-/- NOUN O
compared VERB O
to ADP O
Oct1+/+ NOUN O
mice NOUN O
( PUNCT O
p NOUN O
= SYM O
0.001 NUM O
) PUNCT O
( PUNCT O
Fig PROPN O
2C NUM O
) PUNCT O
. PUNCT O
Consistent ADJ O
with ADP O
the DET O
greater ADJ O
proportion NOUN O
of ADP O
body NOUN O
fat NOUN O
, PUNCT O
Oct1-/- NOUN O
mice NOUN O
had VERB O
greater ADJ O
epididymal ADJ O
fat NOUN O
pad NOUN O
weights NOUN O
and CCONJ O
reduced VERB O
liver NOUN O
weight NOUN O
compared VERB O
to ADP O
Oct1+/+ NOUN O
mice NOUN O
( PUNCT O
p NOUN O
< SYM O
0.0001 NUM O
) PUNCT O
( PUNCT O
Fig PROPN O
2D NUM O
and CCONJ O
S2E PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

Stigma NOUN O
and CCONJ O
high ADJ O
- PUNCT O
care NOUN O
needs NOUN O
can AUX O
present VERB O
barriers NOUN O
to ADP O
the DET O
provision NOUN O
of ADP O
high ADJ O
- PUNCT O
quality NOUN O
primary ADJ O
care NOUN O
for ADP O
people NOUN O
with ADP O
opioid NOUN B-LF
use NOUN I-LF
disorder NOUN I-LF
( PUNCT O
OUD PROPN B-AC
) PUNCT O
and CCONJ O
those PRON O
prescribed VERB O
opioids NOUN O
for ADP O
chronic ADJ O
pain NOUN O
. PUNCT O

The DET O
prevalence NOUN O
of ADP O
obesity NOUN O
, PUNCT O
the DET O
strongest ADJ O
known VERB O
risk NOUN O
factor NOUN O
for ADP O
type NOUN O
2 NUM O
diabetes NOUN O
, PUNCT O
has AUX O
increased VERB O
across ADP O
the DET O
world NOUN O
, PUNCT O
and CCONJ O
more ADV O
so ADV O
in ADP O
African ADJ O
women NOUN O
, PUNCT O
with ADP O
a DET O
recent ADJ O
meta NOUN O
- NOUN O
analysis NOUN O
showing VERB O
that SCONJ O
in ADP O
this DET O
group NOUN O
, PUNCT O
mean ADJ O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT O
BMI PROPN B-AC
) PUNCT O
increased VERB O
from ADP O
22 NUM O
kg NOUN O
/ SYM O
m2 NUM O
in ADP O
1980 NUM O
to ADP O
25 NUM O
kg NOUN O
/ SYM O
m2 NUM O
in ADP O
2014 NUM O
[ PUNCT O
3 NUM O
] PUNCT O
. PUNCT O

MALDI PROPN B-AC
- PUNCT B-AC
TOF PROPN B-AC
- PUNCT B-AC
MS PROPN B-AC
, PUNCT O
matrix NOUN B-LF
- PUNCT I-LF
assisted VERB I-LF
laser NOUN I-LF
desorption NOUN I-LF
/ SYM I-LF
ionization NOUN I-LF
time NOUN I-LF
- PUNCT I-LF
of ADP I-LF
- PUNCT I-LF
flight NOUN I-LF
mass NOUN I-LF
spectrometry NOUN I-LF
; PUNCT O
mamA NOUN B-AC
, PUNCT O
methylarginine NOUN B-LF
modification NOUN I-LF
; PUNCT O
mcmA NOUN B-AC
, PUNCT O
methylcysteine NOUN B-LF
modification NOUN I-LF
; PUNCT O
MCR PROPN B-AC
, PUNCT O
methyl NOUN B-LF
- PUNCT I-LF
coenzyme NOUN I-LF
M PROPN I-LF
reductase NOUN I-LF
; PUNCT O
McrA PROPN B-AC
, PUNCT O
alpha NOUN B-LF
subunit NOUN I-LF
of ADP I-LF
MCR PROPN I-LF
. PUNCT O

Abbreviation NOUN O
: PUNCT O
CI NOUN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
NA NOUN O
, PUNCT O
not PART O
available ADJ O
. PUNCT O

( PUNCT O
a X O
) PUNCT O
66 NUM O
propensity NOUN O
score NOUN O
- PUNCT O
matched VERB O
patients NOUN O
in ADP O
each PRON O
of ADP O
peg NOUN O
- PUNCT O
interferon NOUN B-LF
and CCONJ O
ribavirin NOUN O
( PUNCT O
PEG PROPN B-AC
- PUNCT B-AC
IFN PROPN B-AC
/ SYM B-AC
RBV PROPN B-AC
) PUNCT O
and CCONJ O
daclatasvir NOUN B-LF
plus CCONJ I-LF
asunaprevir NOUN I-LF
( PUNCT O
DCV PROPN B-AC
/ SYM B-AC
ASV PROPN B-AC
) PUNCT O
groups NOUN O
were AUX O
analyzed VERB O
. PUNCT O
( PUNCT O
b X O
) PUNCT O
Patients NOUN O
were AUX O
grouped VERB O
by ADP O
FIB4 PROPN O
index NOUN O
. PUNCT O

Data NOUN O
denote VERB O
mean ADJ O
± ADJ O
SEM NOUN O
, PUNCT O
Student NOUN O
t NOUN O
test NOUN O
( PUNCT O
D NOUN O
, PUNCT O
F NOUN O
) PUNCT O
, PUNCT O
* PUNCT O
p NOUN O
< ADP O
0.05 NUM O
, PUNCT O
* PUNCT O
* PUNCT O
* PUNCT O
p NOUN O
< ADP O
0.001 NUM O
, PUNCT O
* PUNCT O
* PUNCT O
* PUNCT O
* PUNCT O
p NOUN O
< ADP O
0.0001 NUM O
. PUNCT O
a.u NOUN O
. PUNCT O
, PUNCT O
arbitrary ADJ O
unit NOUN O
; PUNCT O
AZ PROPN B-AC
, PUNCT O
active ADJ B-LF
zone NOUN I-LF
; PUNCT O
Brp PROPN B-AC
, PUNCT O
Bruchpilot NOUN B-LF
; PUNCT O
cpx PROPN B-AC
, PUNCT O
complexin NOUN B-LF
; PUNCT O
Ctrl PROPN B-AC
, PUNCT O
control NOUN B-LF
; PUNCT O
eEJC PROPN B-AC
, PUNCT O
evoked VERB B-LF
EJC PROPN I-LF
; PUNCT O
EJC PROPN B-AC
, PUNCT O
excitatory ADJ B-LF
junction NOUN I-LF
current NOUN I-LF
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent NOUN I-LF
protein NOUN I-LF
; PUNCT O
HEK PROPN O
, PUNCT O
human ADJ O
embryonic ADJ O
kidney NOUN O
; PUNCT O
HRP PROPN B-AC
, PUNCT O
horseradish NOUN B-LF
peroxidase NOUN I-LF
; PUNCT O
mEJC PROPN B-AC
, PUNCT O
miniature ADJ B-LF
EJC PROPN I-LF
; PUNCT O
NMJ PROPN B-AC
, PUNCT O
neuromuscular ADJ B-LF
junction NOUN I-LF
; PUNCT O
NO PROPN B-AC
, PUNCT O
nitric NOUN B-LF
oxide NOUN I-LF
; PUNCT O
PLA PROPN B-AC
, PUNCT O
proximity NOUN B-LF
ligation NOUN I-LF
assay NOUN I-LF
; PUNCT O
QC PROPN B-AC
, PUNCT O
quantal ADJ B-LF
content NOUN I-LF
; PUNCT O
STED PROPN B-AC
, PUNCT O
stimulated ADJ B-LF
emission NOUN I-LF
depletion NOUN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

Interestingly ADV O
, PUNCT O
alanine NOUN B-LF
aminotransferase NOUN I-LF
( PUNCT O
ALT PROPN B-AC
) PUNCT O
, PUNCT O
aspartate NOUN B-LF
aminotransferase NOUN I-LF
( PUNCT O
AST PROPN B-AC
) PUNCT O
, PUNCT O
bilirubin NOUN O
, PUNCT O
total ADJ B-LF
cholesterol NOUN I-LF
( PUNCT O
TC PROPN B-AC
) PUNCT O
and CCONJ O
triglyceride NOUN B-LF
( PUNCT O
TG NOUN B-AC
) PUNCT O
profiles NOUN O
confirms VERB O
USG PROPN B-AC
images NOUN O
of ADP O
overweight ADJ O
, PUNCT O
obese ADJ O
patients NOUN O
. PUNCT O

ANC PROPN B-AC
, PUNCT O
anteriormost NOUN B-LF
NC PROPN I-LF
; PUNCT O
Ecad PROPN B-AC
, PUNCT O
Ecadherin NOUN B-LF
; PUNCT O
ERC PROPN B-AC
, PUNCT O
entrance NOUN B-LF
RC PROPN I-LF
; PUNCT O
ES9 PROPN B-AC
, PUNCT O
early ADJ B-LF
S9 NOUN I-LF
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
LS9 PROPN B-AC
, PUNCT O
late ADJ B-LF
S9 NOUN I-LF
; PUNCT O
MS9 PROPN B-AC
, PUNCT O
mid ADJ B-LF
S9 NOUN I-LF
; PUNCT O
NC PROPN B-AC
, PUNCT O
nurse NOUN B-LF
cell NOUN I-LF
; PUNCT O
Oo PROPN O
, PUNCT O
oocyte NOUN O
; PUNCT O
PNC PROPN B-AC
, PUNCT O
posteriormost NOUN B-LF
NC PROPN I-LF
; PUNCT O
RC PROPN B-AC
, PUNCT O
ring NOUN B-LF
canal NOUN I-LF
; PUNCT O
S PROPN O
, PUNCT O
stage NOUN O
. PUNCT O

Based VERB O
on ADP O
the DET O
HTS PROPN B-AC
data NOUN O
from ADP O
the DET O
Argonaute PROPN B-LF
( PUNCT O
AGO)-associated PROPN B-AC
sRNAs NOUN B-AC
, PUNCT O
many ADJ O
Pol PROPN B-AC
IV- PROPN O
, PUNCT O
RDR- PROPN B-AC
and CCONJ O
DCL PROPN B-AC
- PUNCT O
dependent ADJ O
PASRs NOUN B-AC
and CCONJ O
TASRs NOUN B-AC
were AUX O
preferentially ADV O
loaded VERB O
into ADP O
AGO4 PROPN O
silencing VERB O
complexes NOUN O
. PUNCT O

We PRON O
aimed VERB O
to PART O
develop VERB O
and CCONJ O
validate VERB O
vital ADJ O
sign NOUN O
based VERB O
Manchester PROPN B-LF
Triage PROPN I-LF
System PROPN I-LF
( PUNCT O
MTS PROPN B-AC
) PUNCT O
discriminators NOUN O
to PART O
improve VERB O
triage NOUN O
of ADP O
children NOUN O
at ADP O
the DET O
emergency NOUN O
department NOUN O
. PUNCT O

AA PROPN B-AC
, PUNCT O
aortic ADJ B-LF
arch NOUN I-LF
; PUNCT O
dpf PROPN B-AC
, PUNCT O
days NOUN B-LF
post ADP I-LF
fertilization NOUN I-LF
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent NOUN I-LF
protein NOUN I-LF
; PUNCT O
IF PROPN B-AC
, PUNCT O
mmunofluorescence NOUN O
; PUNCT O
kdrl PROPN B-AC
, PUNCT O
kinase NOUN B-LF
insert NOUN I-LF
domain NOUN I-LF
receptor NOUN I-LF
like ADP I-LF
. PUNCT O

To PART O
further ADV O
test VERB O
whether SCONJ O
directional ADJ O
migration NOUN O
of ADP O
antigen NOUN O
- VERB O
engaged VERB O
B NOUN O
cells NOUN O
to ADP O
the DET O
B NOUN B-AC
/ SYM B-AC
T NOUN B-AC
boundary NOUN O
occurred VERB O
in ADP O
response NOUN O
to ADP O
a DET O
CCR7 PROPN O
ligand NOUN O
gradient NOUN O
, PUNCT O
we PRON O
tracked VERB O
the DET O
migration NOUN O
of ADP O
carboxyfluorescein NOUN B-LF
diacetate NOUN I-LF
succinimidyl NOUN I-LF
ester NOUN I-LF
( PUNCT O
CFSE)–labeled VERB B-AC
CCR7−/− NOUN O
Ig NOUN B-AC
- VERB B-AC
tg NOUN B-AC
B NOUN O
cells NOUN O
in ADP O
wild ADJ O
- VERB O
type NOUN O
recipients NOUN O
1–4 NUM O
h NOUN O
after ADP O
antigen NOUN O
exposure NOUN O
. PUNCT O
5-(and-6)-(((4 NUM B-LF
- VERB I-LF
chloromethyl)benzoyl)amino)tetramethylrhodamine NOUN I-LF
( PUNCT O
CMTMR)–labeled NOUN B-AC
CCR7+/+ NOUN O
Ig NOUN B-AC
- VERB B-AC
tg NOUN B-AC
B NOUN O
cells NOUN O
were AUX O
co VERB O
- VERB O
transferred VERB O
with ADP O
the DET O
CCR7−/− NOUN O
cells NOUN O
as ADP O
an DET O
internal ADJ O
control NOUN O
. PUNCT O

The DET O
malaria NOUN O
genome NOUN O
sequencing NOUN O
consortium NOUN O
estimates VERB O
that SCONJ O
more ADJ O
than ADP O
60 NUM O
% NOUN O
of ADP O
the DET O
5,409 NUM O
predicted VERB O
open ADJ B-LF
reading NOUN I-LF
frames NOUN I-LF
( PUNCT O
ORFs PROPN B-AC
) PUNCT O
lack VERB O
sequence NOUN O
similarity NOUN O
to ADP O
genes NOUN O
from ADP O
any DET O
other ADJ O
known VERB O
organism NOUN O
( PUNCT O
Gardner PROPN O
et CCONJ O
al X O
. PUNCT O
2002 NUM O
) PUNCT O
. PUNCT O

All DET O
continuous ADJ O
social ADJ O
determinant ADJ O
exposure NOUN O
variables NOUN O
were AUX O
standardized VERB O
to PART O
a DET O
1 NUM O
– PUNCT O
standard ADJ B-LF
deviation NOUN I-LF
( PUNCT O
SD NOUN B-AC
) PUNCT O
change NOUN O
to PART O
allow VERB O
for ADP O
direct ADJ O
comparisons NOUN O
of ADP O
effect NOUN O
sizes NOUN O
across ADP O
social ADJ O
determinants NOUN O
. PUNCT O

Furthermore ADV O
, PUNCT O
MAX2 PROPN B-AC
directly ADV O
interacts VERB O
with ADP O
the DET O
BR PROPN B-AC
transcriptional ADJ O
effector NOUN O
bri1 PROPN B-LF
- PUNCT I-LF
EMS PROPN I-LF
- PUNCT I-LF
SUPPRESSOR PROPN I-LF
1 NUM I-LF
( PUNCT O
BES1 PROPN B-AC
) PUNCT O
, PUNCT O
leading VERB O
to ADP O
accelerated VERB O
BES1 PROPN B-AC
degradation NOUN O
[ PUNCT O
33 NUM O
] PUNCT O
. PUNCT O

We PRON O
predicted VERB O
that SCONJ O
novelty NOUN O
would AUX O
lead VERB O
to ADP O
a DET O
learning NOUN O
- PUNCT O
independent ADJ O
increase NOUN O
in ADP O
immediate ADJ B-LF
early ADJ I-LF
gene NOUN I-LF
( PUNCT O
IEG PROPN B-AC
) PUNCT O
mRNA NOUN O
expression NOUN O
in ADP O
the DET O
hippocampus NOUN O
related VERB O
to ADP O
the DET O
production NOUN O
of ADP O
plasticity NOUN O
- PUNCT O
related VERB O
proteins NOUN O
implicated VERB O
in ADP O
synaptic ADJ O
tagging NOUN O
and CCONJ O
capture NOUN O
[ X O
32 NUM O
] PUNCT O
and CCONJ O
the DET O
consequent ADJ O
consolidation NOUN O
of ADP O
hippocampal ADJ O
traces NOUN O
[ X O
29 NUM O
] PUNCT O
. PUNCT O

ACKR PROPN B-AC
, PUNCT O
atypical ADJ B-LF
chemokine NOUN I-LF
receptor NOUN I-LF
; PUNCT O
E PROPN O
, PUNCT O
embryonic ADJ O
day NOUN O
; PUNCT O
FSC PROPN O
, PUNCT O
forward ADJ O
scatter NOUN O
; PUNCT O
SSC PROPN O
, PUNCT O
side NOUN O
scatter NOUN O
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
type NOUN I-LF
; PUNCT O
YS PROPN B-AC
, PUNCT O
yolk NOUN B-LF
sac NOUN I-LF
. PUNCT O

Nitrogen NOUN O
- PUNCT O
fixing VERB O
root NOUN B-LF
nodule NOUN I-LF
symbiosis NOUN I-LF
( PUNCT O
RNS NOUN B-AC
) PUNCT O
occurs VERB O
in ADP O
two NUM O
major ADJ O
forms NOUN O
. PUNCT O

Lung NOUN B-LF
adenocarcinoma NOUN I-LF
( PUNCT O
LUAD PROPN B-AC
) PUNCT O
, PUNCT O
a DET O
main ADJ O
subtype NOUN O
of ADP O
NSCLC PROPN B-AC
, PUNCT O
accounts VERB O
for ADP O
approximately ADV O
40 NUM O
% NOUN O
of ADP O
lung NOUN O
cancer NOUN O
patients NOUN O
. PUNCT O

The DET O
oldest ADJ O
cholinergic ADJ O
hypothesis NOUN O
is AUX O
used VERB O
to PART O
elevate VERB O
the DET O
level NOUN O
of ADP O
cognitive ADJ O
impairment NOUN O
and CCONJ O
acetylcholinesterase NOUN B-LF
( PUNCT O
AChE PROPN B-AC
) PUNCT O
comprises VERB O
the DET O
major ADJ O
targeted VERB O
enzyme NOUN O
in ADP O
AD PROPN B-AC
. PUNCT O
Thus ADV O
, PUNCT O
acetylcholinesterase NOUN B-LF
inhibitors NOUN I-LF
( PUNCT O
AChEI PROPN B-AC
) PUNCT O
constitutes VERB O
the DET O
essential ADJ O
remedy NOUN O
for ADP O
the DET O
treatment NOUN O
of ADP O
AD PROPN B-AC
. PUNCT O
The DET O
study NOUN O
aims VERB O
to PART O
evaluate VERB O
the DET O
interactions NOUN O
between ADP O
natural ADJ O
molecules NOUN O
and CCONJ O
AChE PROPN B-AC
by ADP O
Surface PROPN B-LF
Plasmon PROPN I-LF
Resonance PROPN I-LF
( PUNCT O
SPR PROPN B-AC
) PUNCT O
. PUNCT O
The DET O
molecules NOUN O
like ADP O
alkaloids NOUN O
, PUNCT O
polyphenols NOUN O
and CCONJ O
substrates NOUN O
of ADP O
AChE PROPN B-AC
have AUX O
been AUX O
considered VERB O
for ADP O
the DET O
study NOUN O
with ADP O
a DET O
major ADJ O
emphasis NOUN O
on ADP O
affinity NOUN O
and CCONJ O
kinetics NOUN O
. PUNCT O

RIP PROPN B-AC
TG PROPN B-AC
and CCONJ O
WT PROPN B-AC
littermates NOUN O
fed VERB O
a DET O
chow NOUN B-LF
diet NOUN I-LF
( PUNCT O
CD PROPN B-AC
) PUNCT O
exhibited VERB O
similar ADJ O
body NOUN B-LF
weight NOUN I-LF
( PUNCT O
BW NOUN B-AC
) PUNCT O
, PUNCT O
glucose NOUN O
tolerance NOUN O
, PUNCT O
insulin NOUN O
sensitivity NOUN O
, PUNCT O
blood NOUN O
glucose NOUN O
, PUNCT O
blood NOUN O
insulin NOUN O
, PUNCT O
and CCONJ O
tissue NOUN O
morphology NOUN O
( PUNCT O
S3B NOUN O
– SYM O
S3H NOUN O
Fig PROPN O
) PUNCT O
. PUNCT O

No PROPN O
. PUNCT O
Mfr PROPN O
. PUNCT O
: PUNCT O
number NOUN O
of ADP O
manufactures NOUN O
; PUNCT O
DDD PROPN B-AC
: PUNCT O
Defined VERB B-LF
daily ADJ I-LF
dose NOUN I-LF
. PUNCT O

The DET O
pellet NOUN O
durability NOUN O
was AUX O
presented VERB O
as ADP O
a DET O
Pellet PROPN B-LF
Durability PROPN I-LF
Index PROPN I-LF
( PUNCT O
PDI PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
was AUX O
measured VERB O
using VERB O
the DET O
“ PUNCT O
Pfost PROPN O
” PUNCT O
method NOUN O
and CCONJ O
expressed VERB O
on ADP O
a DET O
percentage NOUN O
basis NOUN O
[ PUNCT O
29 NUM O
] PUNCT O
. PUNCT O

CRL PROPN O
, PUNCT O
control NOUN O
; PUNCT O
IF1 NOUN B-AC
, PUNCT O
ATPase NOUN B-LF
inhibitory ADJ I-LF
factor NOUN I-LF
1 NUM I-LF
; PUNCT O
IF1KO PROPN B-AC
, PUNCT O
IF1 NOUN B-LF
knockout NOUN I-LF
; PUNCT O
IF1TG PROPN B-AC
, PUNCT O
IF1 NOUN B-LF
overexpressing ADJ I-LF
transgenic ADJ I-LF
. PUNCT O

NMIBC PROPN B-AC
is AUX O
treated VERB O
by ADP O
transurethral ADJ B-LF
resection NOUN I-LF
of ADP I-LF
the DET I-LF
bladder NOUN I-LF
tumor NOUN I-LF
( PUNCT O
TURBT PROPN B-AC
) PUNCT O
, PUNCT O
followed VERB O
by ADP O
the DET O
administration NOUN O
of ADP O
adjuvant ADJ O
intravesical ADJ O
treatment NOUN O
with ADP O
bacillus NOUN B-LF
Calmette PROPN I-LF
- PUNCT I-LF
Guerin PROPN I-LF
( PUNCT O
BCG PROPN B-AC
) PUNCT O
or CCONJ O
chemotherapeutic ADJ O
agents NOUN O
, PUNCT O
such ADJ O
as ADP O
adriamycin NOUN B-LF
( PUNCT O
ADM PROPN B-AC
) PUNCT O
, PUNCT O
mitomycin NOUN B-LF
C PROPN I-LF
( PUNCT O
MMC PROPN B-AC
) PUNCT O
, PUNCT O
gemcitabine NOUN B-LF
( PUNCT O
GEM PROPN B-AC
) PUNCT O
, PUNCT O
or CCONJ O
docetaxel NOUN B-LF
( PUNCT O
DTX PROPN B-AC
) PUNCT O
[ PUNCT O
4 NUM O
, PUNCT O
5 NUM O
] PUNCT O
. PUNCT O

COVID-19 NOUN B-AC
, PUNCT O
coronavirus NOUN B-LF
disease NOUN I-LF
2019 NUM I-LF
. PUNCT O

The DET O
HT15 PROPN O
team NOUN O
used VERB O
brief ADJ O
messages NOUN O
delivered VERB O
by ADP O
short ADJ B-LF
message NOUN I-LF
service NOUN I-LF
( PUNCT O
SMS PROPN B-AC
) PUNCT O
to PART O
provide VERB O
study NOUN O
participants NOUN O
with ADP O
post ADJ O
- ADJ O
clinic ADJ O
visit NOUN O
support NOUN O
. PUNCT O

The DET O
recombinant ADJ O
plasmids NOUN O
were AUX O
used VERB O
as ADP O
templates NOUN O
for ADP O
RNA NOUN O
synthesis NOUN O
using VERB O
the DET O
T7 PROPN O
Megascript PROPN O
kit NOUN O
( PUNCT O
Ambion PROPN O
) PUNCT O
, PUNCT O
and CCONJ O
15 NUM O
μg NOUN O
of ADP O
double ADJ B-LF
- PUNCT I-LF
stranded ADJ I-LF
RNA NOUN I-LF
( PUNCT O
dsRNA NOUN B-AC
) PUNCT O
were AUX O
added VERB O
to ADP O
106 NUM O
cells NOUN O
in ADP O
all DET O
RNAi NOUN B-AC
experiments NOUN O
. PUNCT O

Clinical PROPN O
and CCONJ O
neuropsychological ADJ O
data NOUN O
were AUX O
reviewed VERB O
at ADP O
multidisciplinary ADJ O
consensus NOUN O
case NOUN O
conferences NOUN O
if SCONJ O
they PRON O
made VERB O
four NUM O
or CCONJ O
more ADJ O
errors NOUN O
on ADP O
the DET O
Blessed PROPN B-LF
Information PROPN I-LF
, PUNCT I-LF
Memory PROPN I-LF
, PUNCT I-LF
and CCONJ I-LF
Concentration PROPN I-LF
( PUNCT O
BIMC PROPN B-AC
) PUNCT O
test NOUN O
, PUNCT O
if SCONJ O
their PRON O
Clinical PROPN B-LF
Dementia PROPN I-LF
Rating PROPN I-LF
( PUNCT O
CDR PROPN B-AC
) PUNCT O
score NOUN O
was AUX O
equal ADJ O
to ADP O
or CCONJ O
greater ADJ O
than ADP O
0.5 NUM O
, PUNCT O
or CCONJ O
if SCONJ O
concerns NOUN O
were AUX O
raised VERB O
about ADP O
their PRON O
cognitive ADJ O
status NOUN O
by ADP O
a DET O
reliable ADJ O
informant NOUN O
. PUNCT O

Fatality NOUN O
rates NOUN O
were AUX O
analyzed VERB O
according VERB O
to ADP O
hospitalization NOUN O
, PUNCT O
intensive ADJ B-LF
care NOUN I-LF
unit NOUN I-LF
( PUNCT O
ICU PROPN B-AC
) PUNCT O
admission NOUN O
, PUNCT O
and CCONJ O
mechanical ADJ B-LF
ventilation NOUN I-LF
( PUNCT O
MV PROPN B-AC
) PUNCT O
requirement NOUN O
. PUNCT O

CFU PROPN B-AC
, PUNCT O
colony NOUN B-LF
forming VERB I-LF
unit NOUN I-LF
. PUNCT O

Indeed ADV O
, PUNCT O
increased VERB O
expression NOUN O
of ADP O
genes NOUN O
in ADP O
NF PROPN B-AC
- PUNCT B-AC
κB PROPN B-AC
pathway NOUN O
in ADP O
human ADJ O
patient NOUN O
peripheral ADJ B-LF
blood NOUN I-LF
mononuclear ADJ I-LF
cells NOUN I-LF
( PUNCT O
PBMCs PROPN B-AC
) PUNCT O
was AUX O
observed VERB O
in ADP O
single ADJ O
- PUNCT O
cell NOUN O
RNA NOUN O
sequencing NOUN O
[ PUNCT O
29 NUM O
] PUNCT O
. PUNCT O

In ADP O
stage NOUN O
one NUM O
, PUNCT O
after SCONJ O
the DET O
nine NUM O
administrative ADJ O
units NOUN O
were AUX O
stratified VERB O
into ADP O
12 NUM O
urban ADJ O
and CCONJ O
11 NUM O
rural ADJ O
strata NOUN O
, PUNCT O
Enumeration PROPN B-LF
Areas PROPN I-LF
( PUNCT O
EAs PROPN B-AC
) PUNCT O
were AUX O
selected VERB O
proportional ADJ O
to ADP O
the DET O
household NOUN O
size NOUN O
of ADP O
the DET O
cluster NOUN O
. PUNCT O

Chlorophyll NOUN B-LF
( PUNCT O
Chl PROPN B-AC
) PUNCT O
was AUX O
extracted VERB O
from ADP O
fresh ADJ O
leaf NOUN O
tissue NOUN O
treated VERB O
with ADP O
25 NUM O
mL NOUN O
of ADP O
ethanol NOUN O
/ NOUN O
acetone NOUN O
( PUNCT O
1/1 NUM O
, PUNCT O
v NOUN O
/ NOUN O
v NOUN O
) PUNCT O
for ADP O
24 NUM O
h NOUN O
in ADP O
the DET O
dark NOUN O
. PUNCT O

Another DET O
strength NOUN O
of ADP O
the DET O
kSORT PROPN B-AC
assay NOUN O
is AUX O
its PRON O
high ADJ O
positive ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
( PUNCT O
PPV NOUN B-AC
) NOUN O
( PUNCT O
93.21 NUM O
% NOUN O
) NOUN O
for ADP O
detecting VERB O
AR PROPN B-AC
in ADP O
a DET O
PB PROPN B-AC
sample NOUN O
. PUNCT O

Moreover ADV O
, PUNCT O
lactate NOUN B-LF
dehydrogenase NOUN I-LF
( PUNCT O
LDH PROPN B-AC
) PUNCT O
analysis NOUN O
of ADP O
co ADJ O
- ADJ O
culture ADJ O
supernatants NOUN O
indicated VERB O
that SCONJ O
cytochalasin NOUN O
D NOUN O
concentration NOUN O
employed VERB O
in ADP O
these DET O
studies NOUN O
was AUX O
not PART O
cytotoxic ADJ O
to ADP O
alveolar ADJ O
macrophages NOUN O
( PUNCT O
unpublished ADJ O
data NOUN O
) PUNCT O
. PUNCT O

During ADP O
the DET O
entry NOUN O
process NOUN O
, PUNCT O
the DET O
human ADJ B-LF
immunodeficiency NOUN I-LF
virus NOUN I-LF
type NOUN I-LF
1 NUM I-LF
( PUNCT O
HIV-1 PROPN B-AC
) PUNCT O
envelope NOUN B-LF
glycoprotein NOUN I-LF
( PUNCT O
Env PROPN B-AC
) PUNCT O
trimer NOUN O
undergoes VERB O
a DET O
sequence NOUN O
of ADP O
conformational ADJ O
changes NOUN O
triggered VERB O
by ADP O
both CCONJ O
CD4 NOUN O
and CCONJ O
coreceptor NOUN O
engagement NOUN O
. PUNCT O

To PART O
avoid VERB O
cases NOUN O
of ADP O
unclear ADJ O
orthology NOUN O
, PUNCT O
we PRON O
required VERB O
both DET O
genes NOUN O
to PART O
be AUX O
the DET O
only ADJ O
members NOUN O
of ADP O
their PRON O
respective ADJ O
COGs NOUN B-AC
( PUNCT O
conserved VERB B-LF
orthologous ADJ I-LF
groups NOUN I-LF
[ X O
36 NUM O
] X O
in ADP O
E. PROPN O
coli PROPN O
K12 PROPN O
( PUNCT O
see VERB O
Materials NOUN O
and CCONJ O
Methods NOUN O
) PUNCT O
. PUNCT O

OS PROPN B-AC
, PUNCT O
overall ADJ B-LF
survival NOUN I-LF
; PUNCT O
PFS PROPN B-AC
, PUNCT O
progression NOUN B-LF
- PUNCT I-LF
free ADJ I-LF
survival NOUN I-LF
. PUNCT O

In ADP O
this DET O
observational ADJ O
study NOUN O
we PRON O
included VERB O
all DET O
fourth ADJ O
- ADJ O
year NOUN O
undergraduate ADJ O
medical ADJ O
students NOUN O
from ADP O
a DET O
French ADJ O
medical ADJ O
school NOUN O
who PRON O
undertook VERB O
a DET O
CS PROPN B-AC
objective ADJ B-LF
structured VERB I-LF
clinical ADJ I-LF
examination ADJ I-LF
( PUNCT O
OSCE PROPN B-AC
) PUNCT O
and CCONJ O
who PRON O
answered VERB O
a DET O
post ADJ O
- ADJ O
examination ADJ O
survey NOUN O
. PUNCT O

DD PROPN B-AC
, PUNCT O
constant ADJ B-LF
darkness NOUN I-LF
. PUNCT O

In ADP O
145 NUM O
healthy ADJ O
, PUNCT O
term NOUN O
- PUNCT O
born VERB O
infants NOUN O
( PUNCT O
85 NUM O
boys NOUN O
) PUNCT O
, PUNCT O
we PRON O
measured VERB O
LTL NOUN B-AC
in ADP O
blood NOUN O
, PUNCT O
expressed VERB O
as ADP O
telomere NOUN B-LF
to ADP I-LF
single ADJ I-LF
- PUNCT I-LF
gene NOUN I-LF
copy NOUN I-LF
ratio NOUN I-LF
( PUNCT O
T NOUN B-AC
/ SYM B-AC
S NOUN B-AC
ratio NOUN B-AC
) PUNCT O
, PUNCT O
at ADP O
3 NUM O
months NOUN O
and CCONJ O
2 NUM O
years NOUN O
by ADP O
quantitative ADJ O
PCR NOUN O
technique NOUN O
. PUNCT O

These DET O
offline ADJ O
improvements NOUN O
were AUX O
linked VERB O
to ADP O
both PRON O
replay NOUN O
of ADP O
task NOUN O
- ADJ O
related VERB O
ensembles NOUN O
during ADP O
non ADJ B-LF
- ADJ I-LF
rapid ADJ I-LF
eye NOUN I-LF
movement NOUN I-LF
( PUNCT O
NREM PROPN B-AC
) PUNCT O
sleep NOUN O
and CCONJ O
temporal ADJ O
shifts NOUN O
that PRON O
more ADV O
tightly ADV O
bound VERB O
motor NOUN O
cortical ADJ O
ensembles NOUN O
to ADP O
movements NOUN O
; PUNCT O
such ADJ O
offline ADJ O
gains NOUN O
and CCONJ O
temporal ADJ O
shifts NOUN O
were AUX O
not PART O
evident ADJ O
with ADP O
sleep NOUN O
restriction NOUN O
. PUNCT O

With ADP O
this DET O
expanded VERB O
dataset NOUN O
, PUNCT O
we PRON O
are AUX O
able ADJ O
to PART O
put VERB O
the DET O
results NOUN O
from ADP O
Shaw PROPN O
et X O
al NOUN O
. PUNCT O
[ X O
27 NUM O
] X O
in ADP O
a DET O
larger ADJ O
context NOUN O
, PUNCT O
and CCONJ O
determine VERB O
whether SCONJ O
there PRON O
have AUX O
been AUX O
consistent ADJ O
changes NOUN O
in ADP O
grassland NOUN O
net NOUN B-LF
primary ADJ I-LF
production NOUN I-LF
( PUNCT O
NPP PROPN B-AC
) PUNCT O
that PRON O
could AUX O
directly ADV O
affect VERB O
the DET O
amount NOUN O
of ADP O
C PROPN O
stored VERB O
in ADP O
this DET O
ecosystem NOUN O
. PUNCT O

To ADP O
this DET O
end NOUN O
, PUNCT O
we PRON O
analyzed VERB O
Dvl PROPN B-AC
phosphorylation NOUN O
in ADP O
response NOUN O
to ADP O
Wnt5a PROPN O
treatment NOUN O
in ADP O
wild ADJ O
- PUNCT O
type NOUN O
versus ADP O
APP PROPN B-AC
/ SYM O
APLP2 PROPN O
double ADJ B-LF
knock ADJ I-LF
- PUNCT I-LF
out ADP I-LF
mouse NOUN B-LF
embryonic ADJ I-LF
fibroblast NOUN I-LF
( PUNCT O
dKO PROPN B-AC
MEFs PROPN B-AC
) PUNCT O
. PUNCT O

Microbial ADJ O
community NOUN O
analysis NOUN O
was AUX O
performed VERB O
using VERB O
the DET O
Human PROPN B-LF
Gut PROPN I-LF
Chip PROPN I-LF
( PUNCT O
HuGChip PROPN B-AC
) PUNCT O
( PUNCT O
GSE44752 PROPN O
) PUNCT O
as SCONJ O
described VERB O
[ PUNCT O
29 NUM O
] PUNCT O
. PUNCT O

Unexpectedly ADV O
, PUNCT O
we PRON O
found VERB O
that SCONJ O
Notch1 NOUN O
- PUNCT O
expressing VERB O
cells NOUN O
invariably ADV O
lacked VERB O
the DET O
expression NOUN O
of ADP O
ERα NOUN B-AC
and CCONJ O
PR NOUN B-AC
( PUNCT O
Fig NOUN O
. PUNCT O
2F NUM O
, PUNCT O
G NOUN O
) PUNCT O
, PUNCT O
and CCONJ O
we PRON O
confirmed VERB O
these DET O
results NOUN O
by ADP O
quantitative ADJ B-LF
Real ADJ I-LF
Time PROPN I-LF
Polymerase PROPN I-LF
Chain PROPN I-LF
Reaction PROPN I-LF
( PUNCT O
qRT NOUN B-AC
- PUNCT B-AC
PCR PROPN B-AC
) PUNCT O
in ADP O
sorted VERB O
GFP PROPN B-AC
- PUNCT O
labeled VERB O
cells NOUN O
( PUNCT O
S3B NOUN O
, PUNCT O
C NOUN O
Fig NOUN O
. PUNCT O
) PUNCT O
. PUNCT O

The DET O
lectin NOUN O
staining NOUN O
was AUX O
demonstrated VERB O
with ADP O
fluorescently ADV O
labeled VERB O
Concavalia PROPN O
ensiformis NOUN O
( PUNCT O
ConA PROPN B-AC
) PUNCT O
[ PUNCT O
18 NUM O
] PUNCT O
, PUNCT O
Lycopersicon NOUN B-LF
esculentum NOUN I-LF
lectin NOUN I-LF
( PUNCT O
LEL PROPN B-AC
) PUNCT O
[ PUNCT O
19 NUM O
] PUNCT O
, PUNCT O
Sambucus NOUN O
nigra NOUN O
( PUNCT O
SNL PROPN B-AC
) PUNCT O
[ PUNCT O
20 NUM O
] PUNCT O
, PUNCT O
Solanum NOUN O
tuberosum NOUN O
( PUNCT O
STA PROPN B-AC
) PUNCT O
[ PUNCT O
21 NUM O
] PUNCT O
and CCONJ O
wheat NOUN B-LF
germ NOUN I-LF
agglutinin NOUN I-LF
( PUNCT O
WGA PROPN B-AC
) PUNCT O
[ PUNCT O
22 NUM O
] PUNCT O
. PUNCT O

Light ADJ O
, PUNCT O
light ADJ O
- PUNCT O
intensity NOUN O
activity NOUN O
; PUNCT O
MVPA PROPN B-AC
, PUNCT O
moderate ADJ B-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
vigorous ADJ I-LF
physical ADJ I-LF
activity NOUN I-LF
; PUNCT O
Sed PROPN O
, PUNCT O
sedentary ADJ O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
ADL PROPN B-AC
, PUNCT O
activities NOUN B-LF
of ADP I-LF
daily ADJ I-LF
living NOUN I-LF
; PUNCT O
BMI PROPN O
, PUNCT O
body NOUN O
mass NOUN O
index NOUN O
; PUNCT O
CON PROPN O
, PUNCT O
Control NOUN O
; PUNCT O
CVD NOUN B-AC
, PUNCT O
Cardiovascular ADJ B-LF
disease NOUN I-LF
; PUNCT O
FLIP PROPN B-AC
, PUNCT O
Flooring PROPN B-LF
for ADP I-LF
Injury PROPN I-LF
Prevention PROPN I-LF
; PUNCT O
INT PROPN O
, PUNCT O
intervention NOUN O
; PUNCT O
TIA PROPN B-AC
, PUNCT O
transient ADJ B-LF
ischemic ADJ I-LF
attack NOUN I-LF
. PUNCT O

FEL PROPN B-AC
: PUNCT O
fixed VERB B-LF
- PUNCT I-LF
effects NOUN I-LF
likelihood NOUN I-LF
; PUNCT O
FUBAR PROPN B-AC
: PUNCT O
fast ADJ B-LF
unconstrained ADJ I-LF
Bayesian ADJ I-LF
approximation NOUN I-LF
; PUNCT O
IFEL PROPN B-AC
: PUNCT O
random ADJ B-LF
- PUNCT I-LF
effects NOUN I-LF
likelihood NOUN I-LF
; PUNCT O
MEME PROPN B-AC
: PUNCT O
mixed VERB B-LF
- PUNCT I-LF
effects NOUN I-LF
model NOUN I-LF
of ADP I-LF
evolution NOUN I-LF
; PUNCT O
REL PROPN B-AC
: PUNCT O
internal ADJ B-LF
branch NOUN I-LF
fixed VERB I-LF
- PUNCT I-LF
effects NOUN I-LF
likelihood NOUN I-LF
; PUNCT O
SLAC PROPN B-AC
: PUNCT O
single ADJ O
- PUNCT O
likelihood NOUN O
ancestor NOUN O
. PUNCT O

They PRON O
have VERB O
important ADJ O
roles NOUN O
in ADP O
receptor NOUN B-LF
tyrosine NOUN I-LF
kinase NOUN I-LF
( PUNCT O
RTK PROPN B-AC
) PUNCT O
and CCONJ O
Notch PROPN O
signalling NOUN O
, PUNCT O
highlighted VERB O
by ADP O
phenotypic ADJ O
resemblance NOUN O
of ADP O
ADAM PROPN B-AC
10/17 NUM O
knockouts NOUN O
with ADP O
those PRON O
of ADP O
Notch PROPN O
, PUNCT O
the DET O
epidermal ADJ B-LF
growth NOUN I-LF
factor NOUN I-LF
receptor NOUN I-LF
( PUNCT O
EGFR PROPN B-AC
) PUNCT O
and CCONJ O
EGFR PROPN B-AC
ligands NOUN O
[ PUNCT O
2],[3],[4],[5 NUM O
] PUNCT O
. PUNCT O

Charlson PROPN B-LF
Comorbidity PROPN I-LF
Index PROPN I-LF
( PUNCT O
CCI PROPN B-AC
) PUNCT O
[ X O
31 NUM O
] X O
was AUX O
used VERB O
to PART O
categorize VERB O
comorbidity NOUN O
of ADP O
the DET O
patients NOUN O
. PUNCT O

A DET O
population NOUN O
of ADP O
10,000 NUM O
living VERB O
cells NOUN O
was AUX O
captured VERB O
and CCONJ O
analyzed VERB O
, PUNCT O
and CCONJ O
all DET O
fluorescence NOUN B-LF
- PUNCT I-LF
activated VERB I-LF
cell NOUN I-LF
sorting NOUN I-LF
( PUNCT O
FACS PROPN B-AC
) PUNCT O
experiments NOUN O
was AUX O
performed VERB O
using VERB O
MOFLO PROPN O
ASTRIOS PROPN O
flow NOUN O
cytometer NOUN O
system NOUN O
( PUNCT O
BECKMAN PROPN O
COULTER PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
and CCONJ O
software NOUN O
Summit PROPN O
6.1 NUM O
. PUNCT O

SP NOUN B-AC
, PUNCT O
synaptopodin NOUN B-LF
. PUNCT O

Chronic ADJ O
kidney NOUN O
disease NOUN O
was AUX O
defined VERB O
as ADP O
an DET O
estimated VERB O
glomular ADJ O
filtration NOUN O
rate NOUN O
( PUNCT O
eGFR PROPN B-AC
) PUNCT O
< ADP O
60 NUM O
ml NOUN O
/ SYM O
min/1.73m2 NUM O
by ADP O
the PRON O
Modification PROPN O
of ADP O
Diet PROPN O
in ADP O
Renal PROPN O
Disease PROPN O
formula.[24 NOUN O
] PUNCT O
HF PROPN B-AC
with ADP O
preserved ADJ O
ejection NOUN O
fraction NOUN O
( PUNCT O
HFPEF PROPN B-AC
) PUNCT O
was AUX O
defined VERB O
as ADP O
HF PROPN B-AC
with ADP O
left ADJ B-LF
ventricular ADJ I-LF
ejection NOUN I-LF
fraction NOUN I-LF
( PUNCT O
LVEF PROPN B-AC
) PUNCT O
≥40%.[25 NUM O
] PUNCT O
The DET O
CHA2DS2 PROPN O
- PUNCT O
VASc PROPN O
score NOUN O
of ADP O
each DET O
patient NOUN O
at ADP O
diagnosis NOUN O
of ADP O
HF PROPN B-AC
was AUX O
calculated VERB O
( PUNCT O
C NOUN O
: PUNCT O
congestive ADJ O
heart NOUN B-LF
failure NOUN I-LF
[ PUNCT O
1 NUM O
point NOUN O
] PUNCT O
; PUNCT O
H NOUN O
: PUNCT O
hypertension NOUN O
[ PUNCT O
1 NUM O
point NOUN O
] PUNCT O
; PUNCT O
A2 X O
: PUNCT O
age NOUN O
65–74 NUM O
years NOUN O
[ PUNCT O
1 NUM O
point NOUN O
] PUNCT O
and CCONJ O
age NOUN O
≥75 NUM O
years NOUN O
[ PUNCT O
2 NUM O
points NOUN O
] PUNCT O
; PUNCT O
D NOUN O
: PUNCT O
diabetes NOUN O
mellitus NOUN O
[ PUNCT O
1 NUM O
point NOUN O
] PUNCT O
; PUNCT O
S NOUN O
: PUNCT O
prior ADJ O
stroke NOUN O
or CCONJ O
transient ADJ O
ischemic ADJ O
attack NOUN O
[ PUNCT O
2 NUM O
points NOUN O
] PUNCT O
; PUNCT O
V NOUN O
: PUNCT O
vascular ADJ O
disease NOUN O
, PUNCT O
defined VERB O
as ADP O
prior ADJ O
myocardial ADJ O
infarction NOUN O
or CCONJ O
peripheral ADJ O
vascular ADJ O
disease NOUN O
[ PUNCT O
1 NUM O
point NOUN O
] PUNCT O
; PUNCT O
and CCONJ O
Sc NOUN O
: PUNCT O
sex NOUN O
category NOUN O
= PUNCT O
female ADJ O
[ PUNCT O
1 NUM O
point]).[14 NOUN O
] PUNCT O
. PUNCT O

RMSEA PROPN B-AC
, PUNCT O
root NOUN B-LF
mean ADJ I-LF
square ADJ I-LF
error NOUN I-LF
of ADP I-LF
approximation NOUN I-LF
; PUNCT O
CI PROPN O
, PUNCT O
confidence NOUN O
interval NOUN O
; PUNCT O
CFI PROPN B-AC
, PUNCT O
comparative ADJ B-LF
fit NOUN I-LF
index NOUN I-LF
; PUNCT O
TLI PROPN B-AC
, PUNCT O
tucker PROPN B-LF
– PUNCT I-LF
lewis PROPN I-LF
index NOUN I-LF
; PUNCT O
SRMR PROPN B-AC
standardised ADJ O
root NOUN O
mean ADJ O
square ADJ O
residual NOUN O
. PUNCT O

MDCK PROPN B-AC
, PUNCT O
human ADJ O
embryonic ADJ O
kidney NOUN O
( PUNCT O
293 PROPN O
T PROPN O
) PUNCT O
, PUNCT O
human ADJ O
lung NOUN O
epithelial ADJ O
( PUNCT O
A549 PROPN O
) PUNCT O
, PUNCT O
and CCONJ O
African ADJ O
green ADJ O
monkey NOUN O
kidney NOUN O
( PUNCT O
Vero PROPN O
) PUNCT O
cells NOUN O
were AUX O
obtained VERB O
from ADP O
the DET O
American PROPN O
Type PROPN O
Culture PROPN O
Collection PROPN O
( PUNCT O
Manassas PROPN O
, PUNCT O
Virginia PROPN O
, PUNCT O
United PROPN O
States PROPN O
of ADP O
America PROPN O
) PUNCT O
and CCONJ O
maintained VERB O
in ADP O
the DET O
appropriate ADJ O
medium NOUN O
( PUNCT O
MDCK PROPN B-AC
cells NOUN O
: PUNCT O
Minimum PROPN B-LF
Essential PROPN I-LF
Medium PROPN I-LF
Eagle PROPN I-LF
with ADP O
Earle PROPN O
’s PART O
BBS PROPN O
( PUNCT O
MEME PROPN B-AC
) PUNCT O
, PUNCT O
Lonza PROPN O
, PUNCT O
Basel PROPN O
, PUNCT O
Switzerland PROPN O
; PUNCT O
293 PROPN O
T PROPN O
, PUNCT O
A549 PROPN O
, PUNCT O
and CCONJ O
Vero PROPN O
cells NOUN O
: PUNCT O
Dulbecco PROPN B-LF
’s PART I-LF
Modified PROPN I-LF
Eagle PROPN I-LF
Medium PROPN I-LF
( PUNCT O
DMEM PROPN B-AC
) PUNCT O
, PUNCT O
Gibco PROPN O
, PUNCT O
Waltham PROPN O
, PUNCT O
Massachusetts PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
supplemented VERB O
with ADP O
10 NUM O
% NOUN O
fetal ADJ O
bovine ADJ O
serum NOUN O
and CCONJ O
antibiotics NOUN O
at ADP O
37 NUM O
° NOUN O
C NOUN O
and CCONJ O
5 NUM O
% NOUN O
CO2 NOUN O
. PUNCT O

To PART O
test VERB O
the DET O
functional ADJ O
properties NOUN O
of ADP O
all DET O
selected VERB O
AGT PROPN B-AC
variants NOUN O
in ADP O
vivo ADJ O
, PUNCT O
we PRON O
employed VERB O
a DET O
protein NOUN O
import NOUN O
assay NOUN O
in ADP O
human ADJ O
fibroblasts NOUN O
, PUNCT O
using VERB O
enhanced ADJ B-LF
green ADJ I-LF
fluorescent ADJ I-LF
protein NOUN I-LF
( PUNCT O
EGFP)-tagged VERB B-AC
AGT PROPN B-AC
. PUNCT O
When SCONJ O
expressing VERB O
EGFP PROPN B-AC
- PUNCT O
AGT PROPN B-AC
without ADP O
further ADJ O
modification NOUN O
in ADP O
fibroblasts NOUN O
, PUNCT O
we PRON O
observed VERB O
that SCONJ O
more ADJ O
than ADP O
90 NUM O
% NOUN O
of ADP O
the DET O
cells NOUN O
exhibited VERB O
a DET O
punctuated VERB O
pattern NOUN O
of ADP O
peroxisomal ADJ O
localization NOUN O
( PUNCT O
Figure PROPN O
3 NUM O
) PUNCT O
. PUNCT O

Additionally ADV O
, PUNCT O
both PRON O
of ADP O
the DET O
antibodies NOUN O
displayed VERB O
lower ADJ O
clearance NOUN B-LF
values NOUN I-LF
( PUNCT O
CI NOUN B-AC
) PUNCT O
and CCONJ O
longer ADJ O
mean ADJ B-LF
residence NOUN I-LF
time NOUN I-LF
( PUNCT O
MRT NOUN B-AC
) PUNCT O
without ADP O
significant ADJ O
differences NOUN O
. PUNCT O

Secondary ADJ O
outcomes NOUN O
included VERB O
BP PROPN B-AC
score NOUN O
, PUNCT O
adenoma NOUN B-LF
detection NOUN I-LF
rate NOUN I-LF
( PUNCT O
ADR PROPN B-AC
) PUNCT O
, PUNCT O
polyp NOUN B-LF
detection NOUN I-LF
rate NOUN I-LF
( PUNCT O
PDR NOUN B-AC
) PUNCT O
, PUNCT O
insertion NOUN O
time NOUN O
, PUNCT O
withdrawal NOUN O
time NOUN O
, PUNCT O
adverse ADJ O
events NOUN O
, PUNCT O
> NUM O
80 NUM O
% NOUN O
purgative ADJ O
intake NOUN O
and CCONJ O
diet NOUN O
compliance NOUN O
. PUNCT O

d X O
Mean NOUN O
and CCONJ O
standard ADJ B-LF
deviation NOUN I-LF
( PUNCT O
SD NOUN B-AC
) PUNCT O
reported VERB O
for ADP O
continuous ADJ O
variable NOUN O
, PUNCT O
median ADJ O
and CCONJ O
inter ADJ O
- ADJ O
quartile ADJ O
range NOUN O
[ X O
IQR X O
] X O
reported VERB O
for ADP O
non ADJ O
- ADJ O
normally ADV O
distributed VERB O
continuous ADJ O
variable NOUN O

AZ PROPN B-AC
, PUNCT O
active ADJ B-LF
zone NOUN I-LF
; PUNCT O
Brp PROPN B-AC
, PUNCT O
Bruchpilot NOUN B-LF
; PUNCT O
cpx PROPN B-AC
, PUNCT O
complexin NOUN B-LF
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
HRP PROPN B-AC
, PUNCT O
horseradish NOUN B-LF
peroxidase NOUN I-LF
; PUNCT O
NMJ PROPN B-AC
, PUNCT O
neuromuscular ADJ B-LF
junction NOUN I-LF
; PUNCT O
PLA PROPN B-AC
, PUNCT O
proximity NOUN B-LF
ligation NOUN I-LF
assay NOUN I-LF
; PUNCT O
STED PROPN B-AC
, PUNCT O
stimulated ADJ B-LF
emission NOUN I-LF
depletion NOUN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

Immobilized ADJ B-LF
pH NOUN I-LF
gradient NOUN I-LF
( PUNCT O
IPG PROPN B-AC
) PUNCT O
strips NOUN O
( PUNCT O
pH NOUN O
3–10 NUM O
, PUNCT O
24 NUM O
cm NOUN O
) PUNCT O
were AUX O
rehydrated VERB O
and CCONJ O
the DET O
prepared VERB O
samples NOUN O
were AUX O
applied VERB O
with ADP O
cup NOUN O
loading NOUN O
. PUNCT O

Empirical ADJ O
studies NOUN O
and CCONJ O
population NOUN O
- PUNCT O
level NOUN O
policy NOUN O
simulations NOUN O
show VERB O
the DET O
importance NOUN O
of ADP O
voluntary ADJ B-LF
medical ADJ I-LF
male ADJ I-LF
circumcision NOUN I-LF
( PUNCT O
VMMC PROPN B-AC
) PUNCT O
in ADP O
generalized ADJ O
epidemics NOUN O
. PUNCT O

Diabetes PROPN O
is AUX O
a DET O
well ADV O
- PUNCT O
known VERB O
risk NOUN O
factor NOUN O
for ADP O
tuberculosis NOUN B-LF
( PUNCT O
TB PROPN B-AC
) PUNCT O
and CCONJ O
is AUX O
increasingly ADV O
prevalent ADJ O
in ADP O
low- ADJ O
and CCONJ O
middle ADJ O
- PUNCT O
income NOUN O
countries NOUN O
, PUNCT O
where SCONJ O
the DET O
burden NOUN O
of ADP O
TB PROPN B-AC
is AUX O
high ADJ O
. PUNCT O

Colony NOUN B-LF
- PUNCT I-LF
forming VERB I-LF
units NOUN I-LF
( PUNCT O
CFUs PROPN B-AC
) PUNCT O
were AUX O
plated VERB O
and CCONJ O
enumerated VERB O
as SCONJ O
described VERB O
above ADV O
. PUNCT O

All DET O
the DET O
sputa NOUN O
from ADP O
patients NOUN O
attending VERB O
routine ADJ O
TB PROPN B-AC
clinic NOUN O
at ADP O
CPGH PROPN O
that PRON O
tested VERB O
positive ADJ O
for ADP O
tuberculosis NOUN B-LF
using VERB O
fluorescent ADJ O
microscopy NOUN O
( PUNCT O
FM PROPN O
) PUNCT O
were AUX O
labeled VERB O
with ADP O
unique ADJ O
corresponding ADJ O
study NOUN O
number NOUN O
and CCONJ O
stored VERB O
in ADP O
the DET O
refrigerator NOUN O
at ADP O
4 NUM O
° NOUN O
C NOUN O
for ADP O
further ADJ O
analysis NOUN O
. PUNCT O

In ADP O
contrast NOUN O
, PUNCT O
an DET O
antibody NOUN O
that SCONJ O
recognizes VERB O
the DET O
dually ADV O
phosphorylated VERB O
form NOUN O
of ADP O
JNKs NOUN B-AC
( PUNCT O
pJNK PROPN O
T183Y185 NOUN O
) PUNCT O
prominently ADV O
stained VERB O
the DET O
growth NOUN O
cone NOUN O
( PUNCT O
Figures NOUN O
S3B NOUN O
and CCONJ O
quantitated VERB O
in ADP O
S2C NOUN O
) PUNCT O
. PUNCT O
Biochemical ADJ O
experiments NOUN O
showed VERB O
that SCONJ O
both DET O
phosphorylated VERB O
JNK PROPN B-AC
forms NOUN O
were AUX O
also ADV O
enriched VERB O
in ADP O
purified VERB O
neurites NOUN O
( PUNCT O
Figure PROPN O
3C NUM O
) PUNCT O
, PUNCT O
and CCONJ O
increased VERB O
concomitantly ADV O
with ADP O
differentiation NOUN O
( PUNCT O
Figure PROPN O
3D NUM O
) PUNCT O
. PUNCT O
Beyond ADP O
the DET O
ability NOUN O
of ADP O
these DET O
JNK PROPN B-AC
isoforms NOUN O
of ADP O
being AUX O
phosphorylated VERB O
in ADP O
the DET O
neurite NOUN O
, PUNCT O
we PRON O
also ADV O
directly ADV O
measured VERB O
JNK PROPN B-AC
activity NOUN O
in ADP O
single ADJ O
living VERB O
cells NOUN O
using VERB O
a DET O
fluorescence NOUN B-LF
resonance NOUN I-LF
energy NOUN I-LF
transfer NOUN I-LF
( PUNCT O
FRET)-based PROPN B-AC
reporter NOUN O
for ADP O
JNK PROPN B-AC
activation NOUN O
( PUNCT O
JNKAR PROPN B-AC
) PUNCT O
[ X O
26 NUM O
] PUNCT O
. PUNCT O

CFU PROPN O
, PUNCT O
colony NOUN O
- PUNCT O
forming VERB O
units NOUN O
; PUNCT O
TSS PROPN B-AC
, PUNCT O
total ADJ B-LF
suspended VERB I-LF
solids NOUN I-LF
. PUNCT O

Body PROPN B-LF
Mass PROPN I-LF
Index PROPN I-LF
( PUNCT O
BMI PROPN B-AC
) PUNCT O
was AUX O
calculated VERB O
in ADP O
kg NOUN O
/ SYM O
m2 NOUN O
. PUNCT O

2 X O
. X O
Does AUX O
SIRT1 PROPN B-AC
level NOUN O
decrease VERB O
after ADP O
TUG1 PROPN O
overexpression NOUN O
in ADP O
high ADJ B-LF
glucose NOUN I-LF
condition NOUN O
( PUNCT O
HG PROPN B-AC
+ SYM O
TUG1 PROPN O
) PUNCT O
? PUNCT O

In ADP O
addition NOUN O
, PUNCT O
VE PROPN B-AC
- NOUN B-AC
cadherin PROPN B-AC
is AUX O
a DET O
critical ADJ O
endothelial ADJ O
regulator NOUN O
of ADP O
transforming VERB B-LF
growth NOUN I-LF
factor NOUN I-LF
- NOUN I-LF
β NOUN I-LF
( PUNCT O
TGF NOUN B-AC
- NOUN B-AC
β NOUN B-AC
) PUNCT O
signaling NOUN O
[ X O
20 NUM O
] PUNCT O
. PUNCT O

Examples NOUN O
of ADP O
EWS PROPN B-AC
are AUX O
the DET O
Modified PROPN B-LF
Early PROPN I-LF
Warning PROPN I-LF
Score PROPN I-LF
( PUNCT O
MEWS PROPN B-AC
) PUNCT O
and CCONJ O
the DET O
National PROPN B-LF
Early PROPN I-LF
Warning PROPN I-LF
Score PROPN I-LF
( PUNCT O
NEWS PROPN B-AC
) PUNCT O
. PUNCT O
However ADV O
, PUNCT O
EWS PROPN B-AC
are AUX O
developed VERB O
to PART O
detect VERB O
inpatient ADJ O
clinical ADJ O
deterioration NOUN O
and CCONJ O
the DET O
predictive ADJ O
value NOUN O
of ADP O
EWS PROPN B-AC
for ADP O
mortality NOUN O
in ADP O
the DET O
ED PROPN B-AC
varies VERB O
[ PUNCT O
8 NUM O
, PUNCT O
9 NUM O
] PUNCT O
and CCONJ O
both CCONJ O
validation NOUN O
and CCONJ O
calibration NOUN O
are AUX O
inadequate ADJ O
or CCONJ O
lacking ADJ O
[ PUNCT O
10 NUM O
] PUNCT O
. PUNCT O

We PRON O
found VERB O
that SCONJ O
vsc1 NOUN O
mutants NOUN O
, PUNCT O
similar ADJ O
to ADP O
other ADJ O
lin-22 NOUN O
mutants NOUN O
generated VERB O
via ADP O
Clustered PROPN B-LF
Regularly ADV I-LF
Interspaced PROPN I-LF
Short PROPN I-LF
Palindromic PROPN I-LF
Repeats PROPN I-LF
/ SYM I-LF
CRISPR PROPN I-LF
- PUNCT I-LF
associated VERB I-LF
protein-9 NOUN I-LF
( PUNCT O
CRISPR PROPN B-AC
/ SYM B-AC
Cas9 PROPN B-AC
) PUNCT O
genome NOUN O
editing NOUN O
or CCONJ O
recovered VERB O
from ADP O
independent ADJ O
mutagenesis NOUN O
experiments NOUN O
also ADV O
showed VERB O
a DET O
significant ADJ O
increase NOUN O
in ADP O
PDE NOUN B-AC
number NOUN O
as SCONJ O
monitored VERB O
by ADP O
an DET O
increase NOUN O
in ADP O
dat-1∷GFP NOUN B-AC
foci NOUN O
[ X O
41 NUM O
] X O
( PUNCT O
Fig PROPN O
2B NUM O
and CCONJ O
S2A PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

Assumptions NOUN O
were AUX O
the DET O
following VERB O
: PUNCT O
intracluster ADJ B-LF
correlation NOUN I-LF
coefficient NOUN I-LF
( PUNCT O
ICC PROPN B-AC
) PUNCT O
due ADJ O
to PART O
clustering NOUN O
by ADP O
ward NOUN O
of ADP O
0.2 NUM O
within ADP O
each DET O
arm NOUN O
( PUNCT O
based VERB O
on ADP O
population NOUN O
level NOUN O
data NOUN O
from ADP O
a DET O
community NOUN O
- PUNCT O
based VERB O
sample NOUN O
in ADP O
Nepal PROPN O
[ PUNCT O
26 NUM O
] PUNCT O
) PUNCT O
, PUNCT O
2 NUM O
- PUNCT O
tailed ADJ O
5 NUM O
% NOUN O
significance NOUN O
level NOUN O
, PUNCT O
72 NUM O
clusters NOUN O
( PUNCT O
36 NUM O
per ADP O
arm NOUN O
) PUNCT O
with ADP O
8 NUM O
participants NOUN O
per ADP O
ward NOUN O
, PUNCT O
and CCONJ O
dropout NOUN O
of ADP O
up ADP O
to PART O
2 NUM O
per ADP O
ward NOUN O
. PUNCT O

We PRON O
calculated VERB O
the DET O
sensitivity NOUN O
, PUNCT O
specificity NOUN O
, PUNCT O
positive ADJ B-LF
likelihood NOUN I-LF
ratio NOUN I-LF
( PUNCT O
PLR PROPN B-AC
) PUNCT O
, PUNCT O
negative ADJ B-LF
likelihood NOUN I-LF
ratio NOUN I-LF
( PUNCT O
NLR PROPN B-AC
) PUNCT O
, PUNCT O
positive ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
( PUNCT O
PPV PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
negative ADJ B-LF
predictive ADJ I-LF
values NOUN I-LF
( PUNCT O
NPVs NOUN B-AC
) PUNCT O
for ADP O
each DET O
score NOUN O
. PUNCT O

DKO PROPN B-AC
, PUNCT O
double ADJ B-LF
knockout NOUN I-LF
; PUNCT O
LSK PROPN B-AC
, PUNCT O
Lin−Sca1+cKit+ NOUN O
; PUNCT O
RNA NOUN B-AC
- PUNCT B-AC
seq NOUN B-AC
, PUNCT O
RNA NOUN O
sequencing NOUN O
. PUNCT O

SIS PROPN B-AC
- PUNCT O
ECM PROPN B-AC
; PUNCT O
Small ADJ B-LF
intestinal ADJ I-LF
submucosa NOUN I-LF
extra ADJ B-LF
cellular ADJ I-LF
matrix NOUN I-LF
. PUNCT O
* PUNCT O
Decellularized VERB O
. PUNCT O

OR NOUN B-AC
, PUNCT O
Odds NOUN B-LF
Ratio NOUN I-LF
; PUNCT O
CI NOUN B-AC
, PUNCT O
Confidence NOUN B-LF
Interval NOUN I-LF
; PUNCT O
ref NOUN O
, PUNCT O
reference NOUN O
; PUNCT O
N NOUN O
, PUNCT O
number NOUN O
. PUNCT O

MYLK PROPN B-AC
encodes VERB O
the DET O
multi ADJ O
- ADJ O
functional ADJ O
myosin NOUN B-LF
light ADJ I-LF
chain NOUN I-LF
kinase NOUN I-LF
( PUNCT O
MLCK PROPN B-AC
) PUNCT O
which PRON O
is AUX O
involved ADJ O
in ADP O
diverse ADJ O
functions NOUN O
in ADP O
multiple ADJ O
types NOUN O
of ADP O
cancer NOUN O
. PUNCT O

To PART O
prepare VERB O
antibiotic ADJ O
disc NOUN O
we PRON O
followed VERB O
the DET O
procedure NOUN O
suggested VERB O
by ADP O
Clinical PROPN B-LF
Laboratory PROPN I-LF
Standard PROPN I-LF
Institute PROPN I-LF
( PUNCT O
CLSI PROPN B-AC
) PUNCT O
[ PUNCT O
14 NUM O
] PUNCT O
. PUNCT O

For ADP O
metabolic ADJ O
and CCONJ O
dietary ADJ O
factors NOUN O
, PUNCT O
external ADJ O
validation NOUN O
was AUX O
performed VERB O
by ADP O
evaluating VERB O
data NOUN O
of ADP O
the DET O
US PROPN O
National PROPN B-LF
Health PROPN I-LF
and CCONJ I-LF
Nutrition PROPN I-LF
Examination PROPN I-LF
Survey PROPN I-LF
( PUNCT O
NHANES PROPN B-AC
) PUNCT O
. PUNCT O

A DET O
further ADJ O
change NOUN O
that PRON O
is AUX O
likely ADJ O
to PART O
be AUX O
required VERB O
to PART O
allow VERB O
cells NOUN O
using VERB O
the DET O
ALT PROPN B-AC
pathway NOUN O
to PART O
escape VERB O
telomere NOUN O
crisis NOUN O
is AUX O
a DET O
deficiency NOUN O
in ADP O
the DET O
cyclic ADJ B-LF
GMP PROPN I-LF
- PUNCT I-LF
AMP PROPN I-LF
synthase NOUN I-LF
( PUNCT O
cGAS)–stimulator NOUN B-LF
of ADP I-LF
interferon NOUN I-LF
genes NOUN I-LF
( PUNCT O
STING PROPN B-AC
) PUNCT O
pathway NOUN O
. PUNCT O

LiST PROPN B-AC
, PUNCT O
Lives NOUN B-LF
Saved VERB I-LF
Tool NOUN I-LF
. PUNCT O

Approval NOUN O
for ADP O
the DET O
use NOUN O
of ADP O
anonymised ADJ O
data NOUN O
in ADP O
this DET O
study NOUN O
was AUX O
granted VERB O
by ADP O
an DET O
independent ADJ O
Information PROPN B-LF
Governance PROPN I-LF
Review PROPN I-LF
Panel PROPN I-LF
( PUNCT O
IGRP PROPN B-AC
) PUNCT O
, PUNCT O
with SCONJ O
membership NOUN O
comprised VERB O
of ADP O
senior ADJ O
representatives NOUN O
from ADP O
the DET O
British PROPN B-LF
Medical PROPN I-LF
Association PROPN I-LF
( PUNCT O
BMA PROPN B-AC
) PUNCT O
, PUNCT O
the DET O
National PROPN B-LF
Research PROPN I-LF
Ethics PROPN I-LF
Service PROPN I-LF
( PUNCT O
NRES PROPN B-AC
) PUNCT O
, PUNCT O
Public PROPN B-LF
Health PROPN I-LF
Wales PROPN I-LF
and CCONJ I-LF
NHS PROPN I-LF
Wales PROPN I-LF
Informatics PROPN I-LF
Service PROPN I-LF
( PUNCT O
NWIS PROPN B-AC
) PUNCT O
. PUNCT O

Therefore ADV O
the DET O
local ADJ O
authorities NOUN O
at ADP O
each DET O
level NOUN O
of ADP O
health NOUN O
sector NOUN O
or CCONJ O
the DET O
nongovernmental ADJ O
organizations NOUN O
working VERB O
to PART O
improve VERB O
maternal ADJ O
health NOUN O
need VERB O
to PART O
provide VERB O
training NOUN O
on ADP O
focused VERB O
antenatal ADJ B-LF
care NOUN I-LF
protocol NOUN O
for ADP O
ANC PROPN B-AC
providers NOUN O
. PUNCT O

Obesity PROPN O
has AUX O
been AUX O
consistently ADV O
associated VERB O
with ADP O
increased VERB O
risks NOUN O
of ADP O
certain ADJ O
chronic ADJ O
diseases NOUN O
, PUNCT O
such ADJ O
as ADP O
cardiovascular ADJ B-LF
disease NOUN I-LF
( PUNCT O
CVD NOUN B-AC
) PUNCT O
, PUNCT O
type NOUN B-LF
2 NUM I-LF
diabetes NOUN I-LF
( PUNCT O
T2D NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
cancer NOUN O
[ PUNCT O
1–4 NUM O
] PUNCT O
. PUNCT O

Important ADJ O
differences NOUN O
exist VERB O
in ADP O
the DET O
diagnosis NOUN O
of ADP O
malnutrition NOUN O
when SCONJ O
comparing VERB O
the DET O
2006 NUM O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT O
WHO PROPN B-AC
) PUNCT O
Child PROPN O
Growth PROPN O
Standards PROPN O
and CCONJ O
the DET O
1977 NUM O
National PROPN B-LF
Center PROPN I-LF
for ADP I-LF
Health PROPN I-LF
Statistics PROPN I-LF
( PUNCT O
NCHS PROPN B-AC
) PUNCT O
reference NOUN O
. PUNCT O

ART PROPN B-AC
, PUNCT O
antiretroviral ADJ B-LF
therapy NOUN I-LF
; PUNCT O
LTFU PROPN B-AC
, PUNCT O
loss NOUN B-LF
to ADP I-LF
follow NOUN I-LF
- PUNCT I-LF
up NOUN I-LF
; PUNCT O
MPR PROPN B-AC
, PUNCT O
medication NOUN B-LF
possession NOUN I-LF
ratio NOUN I-LF
. PUNCT O

1 NUM O
Applies VERB O
to ADP O
CARE PROPN B-AC
’s PART O
INHP PROPN B-AC
II PROPN B-AC
( PUNCT O
Integrated PROPN B-LF
Nutrition PROPN I-LF
and CCONJ I-LF
Health PROPN I-LF
Program–“Intervention PROPN I-LF
district NOUN O
” PUNCT O
) PUNCT O
. PUNCT O

ChR2 PROPN B-AC
, PUNCT O
channelrhodopsin NOUN B-LF
; PUNCT O
F PROPN B-AC
/ SYM B-AC
F0 PROPN B-AC
, PUNCT O
fluorescence NOUN B-LF
over ADP I-LF
background NOUN I-LF
; PUNCT O
FFT PROPN B-AC
, PUNCT O
fast ADJ B-LF
Fourier NOUN I-LF
transform NOUN I-LF
; PUNCT O
GCaMP6 PROPN B-AC
, PUNCT O
circular ADJ B-LF
permutated ADJ I-LF
green ADJ I-LF
florescent ADJ I-LF
protein NOUN I-LF
- PUNCT I-LF
Calmodulin NOUN I-LF
- PUNCT I-LF
M13 PROPN I-LF
peptide NOUN I-LF
6 NUM I-LF
; PUNCT O
H2B PROPN B-AC
, PUNCT O
Histone PROPN B-LF
2B NUM I-LF
; PUNCT O
NLS PROPN O
, PUNCT O
nuclear ADJ O
localization NOUN O
sequence NOUN O
; PUNCT O
SwiChR PROPN B-AC
, PUNCT O
mutated VERB B-LF
channelrhodopsin NOUN I-LF
; PUNCT O
YFP PROPN O
, PUNCT O
yellow ADJ O
fluorescent ADJ O
protein NOUN O
. PUNCT O

Note VERB O
: PUNCT O
polygon NOUN O
areas NOUN O
represent VERB O
95 NUM O
% NOUN O
CI NOUN B-AC
. PUNCT O
CI NOUN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
RR NOUN B-AC
, PUNCT O
relative ADJ B-LF
risk NOUN I-LF
. PUNCT O

Bioluminescence NOUN B-LF
resonance NOUN I-LF
energy NOUN I-LF
transfer NOUN I-LF
( PUNCT O
BRET PROPN B-AC
) PUNCT O
plasmids NOUN O
were AUX O
created VERB O
and CCONJ O
synthesized VERB O
by ADP O
Genscript PROPN O
( PUNCT O
Piscataway PROPN O
, PUNCT O
NJ PROPN O
) PUNCT O
for ADP O
the DET O
5 NUM B-AC
- PUNCT B-AC
HT2AR NOUN B-AC
, PUNCT O
5 NUM B-AC
- PUNCT B-AC
HT2CR NOUN B-AC
and CCONJ O
the DET O
β2 NOUN B-LF
- PUNCT I-LF
adrenergic NOUN I-LF
receptor NOUN I-LF
( PUNCT O
β2 NOUN B-AC
- PUNCT B-AC
AR NOUN B-AC
, PUNCT O
control NOUN O
for ADP O
specificity NOUN O
of ADP O
the DET O
BRET PROPN B-AC
interaction NOUN O
) PUNCT O
. PUNCT O

GSEA PROPN B-AC
identified VERB O
significant ADJ O
enrichment NOUN O
( PUNCT O
false ADJ B-LF
discovery NOUN I-LF
rate NOUN I-LF
[ X O
FDR NOUN B-AC
] X O
q NOUN O
- NOUN O
value NOUN O
< ADP O
0.01 NUM O
) PUNCT O
of ADP O
ten NUM O
expression NOUN O
signatures NOUN O
with ADP O
common ADJ O
biological ADJ O
function NOUN O
that PRON O
are AUX O
differentially ADV O
expressed VERB O
between ADP O
the DET O
unexposed ADJ O
and CCONJ O
exposed ADJ O
newborns NOUN O
. PUNCT O

Underlying VERB O
data NOUN O
can AUX O
be AUX O
found VERB O
in ADP O
S1 PROPN O
Data PROPN O
. PUNCT O
mu NOUN O
- PUNCT O
specific ADJ O
, PUNCT O
muscle NOUN O
- PUNCT O
specific ADJ O
; PUNCT O
RU486 NOUN B-AC
, PUNCT O
mifepristone NOUN B-LF
. PUNCT O

Control NOUN O
experiments NOUN O
established VERB O
that SCONJ O
strains NOUN O
with ADP O
lac ADJ O
and CCONJ O
cat NOUN B-AC
amplification NOUN O
( PUNCT O
as SCONJ O
shown VERB O
by ADP O
unstable ADJ O
phenotypes NOUN O
and CCONJ O
Southern ADJ O
blot NOUN O
analyses NOUN O
) PUNCT O
could AUX O
grow VERB O
on ADP O
rich ADJ O
Luria PROPN B-LF
- PUNCT I-LF
Bertani PROPN I-LF
- PUNCT I-LF
Herskowitz PROPN I-LF
medium NOUN I-LF
( PUNCT O
LBH PROPN B-AC
) PUNCT O
containing VERB O
100 NUM O
μg NOUN O
/ SYM O
ml NOUN O
chloramphenicol NOUN O
, PUNCT O
whereas SCONJ O
Lac+ NOUN O
point NOUN O
- PUNCT O
mutant ADJ O
cells NOUN O
, PUNCT O
and CCONJ O
those PRON O
amplified VERB O
at ADP O
lac ADJ O
but CCONJ O
not PART O
at ADP O
cat NOUN B-AC
, PUNCT O
did AUX O
not PART O
form VERB O
colonies NOUN O
at ADP O
this DET O
concentration NOUN O
. PUNCT O

The DET O
outer ADJ O
structure NOUN O
of ADP O
PS PROPN B-AC
is AUX O
more ADV O
ordered ADJ O
in ADP O
the DET O
outer ADJ O
regions NOUN O
[ PUNCT O
27 NUM O
] PUNCT O
, PUNCT O
which PRON O
might AUX O
be AUX O
the DET O
reason NOUN O
, PUNCT O
at ADP O
least ADJ O
in ADP O
part NOUN O
, PUNCT O
why SCONJ O
the DET O
hydrolyzed VERB B-LF
native ADJ I-LF
potato NOUN I-LF
starch NOUN I-LF
( PUNCT O
hNPS PROPN B-AC
) PUNCT O
without ADP O
pre ADJ O
- PUNCT O
HHP PROPN B-AC
treatment NOUN O
showed VERB O
greater ADJ O
resistance NOUN O
to ADP O
enzymatic ADJ O
hydrolysis NOUN O
compared VERB O
to ADP O
HHP PROPN B-AC
- PUNCT O
treated VERB O
starch NOUN O
. PUNCT O

ACT PROPN B-AC
, PUNCT O
antenatal ADJ B-LF
corticosteroid NOUN I-LF
therapy NOUN I-LF
; PUNCT O
PSM PROPN B-AC
, PUNCT O
propensity NOUN B-LF
score NOUN I-LF
matching NOUN I-LF
. PUNCT O

CI PROPN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
. PUNCT O

RTI NOUN B-AC
testing NOUN O
comprised VERB O
NG PROPN B-AC
and CCONJ O
CT PROPN B-AC
nucleic ADJ O
acid NOUN O
amplification NOUN O
testing NOUN O
with ADP O
NG PROPN B-AC
/ SYM O
CT PROPN B-AC
Xpert PROPN O
( PUNCT O
Cepheid PROPN O
Diagnostics PROPN O
, PUNCT O
Sunnyvale PROPN O
, PUNCT O
CA PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
, PUNCT O
TV NOUN B-AC
and CCONJ O
BV PROPN B-AC
rapid ADJ B-LF
diagnostic ADJ I-LF
tests NOUN I-LF
( PUNCT O
RDTs NOUN B-AC
) PUNCT O
for ADP O
genital ADJ O
tract NOUN O
specimens NOUN O
with ADP O
OSOM PROPN O
Trichomonas PROPN O
and CCONJ O
BV PROPN B-AC
Blue PROPN O
( PUNCT O
Sekisui PROPN O
Diagnostics PROPN O
, PUNCT O
Lexington PROPN O
, PUNCT O
MA PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
, PUNCT O
and CCONJ O
TP PROPN B-AC
with ADP O
Alere PROPN O
Determine PROPN O
Syphilis PROPN O
( PUNCT O
Alere PROPN O
Diagnostics PROPN O
, PUNCT O
San PROPN O
Diego PROPN O
, PUNCT O
CA PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
RDT NOUN B-AC
for ADP O
whole ADJ O
blood NOUN O
with ADP O
reflex NOUN O
Rapid PROPN O
Plasma PROPN O
Reagin PROPN O
titer NOUN O
testing NOUN O
of ADP O
plasma NOUN O
, PUNCT O
according VERB O
to ADP O
package NOUN O
instructions NOUN O
. PUNCT O

To PART O
determine VERB O
the DET O
origin NOUN O
of ADP O
the DET O
neoplastic ADJ O
cell NOUN O
in ADP O
central ADJ B-LF
nervous ADJ I-LF
system NOUN I-LF
( PUNCT O
CNS PROPN B-AC
) PUNCT O
hemangioblastomas NOUN O
in ADP O
von PROPN B-LF
Hippel PROPN I-LF
- PUNCT I-LF
Lindau PROPN I-LF
disease NOUN I-LF
( PUNCT O
VHL PROPN B-AC
) PUNCT O
and CCONJ O
its PRON O
role NOUN O
in ADP O
tumor NOUN O
formation NOUN O
and CCONJ O
distribution NOUN O
, PUNCT O
we PRON O
characterized VERB O
and CCONJ O
differentiated VERB O
neoplastic ADJ O
cells NOUN O
from ADP O
hemangioblastomas NOUN O
removed VERB O
from ADP O
VHL PROPN B-AC
patients NOUN O
. PUNCT O

Flies NOUN O
detect VERB O
volatile ADJ O
pheromones NOUN O
and CCONJ O
other ADJ O
odors NOUN O
important ADJ O
for ADP O
the DET O
initiation NOUN O
of ADP O
courtship NOUN O
and CCONJ O
aggression NOUN O
via ADP O
olfactory ADJ B-LF
receptors NOUN I-LF
( PUNCT O
ORs NOUN B-AC
) PUNCT O
expressed VERB O
in ADP O
ORNs PROPN B-AC
[ PUNCT O
12 NUM O
] PUNCT O
. PUNCT O

The DET O
functional ADJ B-LF
MRI NOUN I-LF
( PUNCT O
fMRI NOUN B-AC
) PUNCT O
data NOUN O
can AUX O
be AUX O
found VERB O
in ADP O
http://neurovault.org/collections/2503/. X O

Instead ADV O
, PUNCT O
we PRON O
took VERB O
advantage NOUN O
of ADP O
mice NOUN O
lacking VERB O
the DET O
adaptor NOUN O
molecule NOUN O
SH2 NOUN B-LF
domain NOUN I-LF
- PUNCT I-LF
containing VERB I-LF
leukocyte NOUN I-LF
protein-76 NOUN I-LF
( PUNCT O
SLP-76 NOUN B-AC
) PUNCT O
. PUNCT O

The DET O
World PROPN O
Health PROPN O
Organization PROPN O
( PUNCT O
WHO PROPN B-AC
) PUNCT O
recommends VERB O
giving VERB O
single ADJ O
( PUNCT O
400 NUM O
mg NOUN O
for ADP O
albendazole NOUN O
, PUNCT O
500 NUM O
mg NOUN O
for ADP O
mebendazole NOUN O
) PUNCT O
doses NOUN O
of ADP O
benzimidazoles NOUN O
to ADP O
pre NOUN B-LF
- ADJ I-LF
school NOUN I-LF
age NOUN I-LF
children NOUN I-LF
( PUNCT O
pre NOUN B-AC
- ADJ B-AC
SAC PROPN B-AC
) PUNCT O
and CCONJ O
school NOUN B-LF
age NOUN I-LF
children NOUN I-LF
( PUNCT O
SAC PROPN B-AC
) PUNCT O
in ADP O
endemic ADJ O
communities NOUN O
( PUNCT O
the DET O
latter ADJ O
defined VERB O
as ADP O
having VERB O
≥20 NUM O
% NOUN O
overall ADJ O
prevalence NOUN O
) PUNCT O
at ADP O
least ADJ O
annually ADV O
as ADP O
part NOUN O
of ADP O
the DET O
preventive ADJ B-LF
chemotherapy NOUN I-LF
and CCONJ I-LF
transmission NOUN I-LF
control NOUN I-LF
( PUNCT O
PCT PROPN B-AC
) PUNCT O
strategy NOUN O
delivered VERB O
by ADP O
mass PROPN B-LF
drug PROPN I-LF
administration NOUN I-LF
( PUNCT O
MDA PROPN B-AC
) PUNCT O
[ PUNCT O
3 NUM O
] PUNCT O
. PUNCT O

Diagnostics NOUN O
were AUX O
also ADV O
conducted VERB O
through ADP O
the DET O
use NOUN O
of ADP O
rapid ADJ B-LF
diagnostic ADJ I-LF
tests NOUN I-LF
( PUNCT O
RDTs PROPN B-AC
) PUNCT O
. PUNCT O

Activation NOUN O
of ADP O
the DET O
MIHR PROPN B-AC
( PUNCT O
green NOUN O
) PUNCT O
at ADP O
the DET O
oocyte NOUN O
surface NOUN O
releases VERB O
GαS PROPN O
to PART O
promote VERB O
an DET O
increase NOUN O
in ADP O
cytoplasmic ADJ O
cAMP NOUN B-AC
, PUNCT O
activating VERB O
PKA PROPN B-AC
. PUNCT O
Unknown ADJ O
PKA PROPN B-AC
substrates NOUN O
likely ADV O
trigger VERB O
in ADP O
parallel ADJ O
Cdk1 PROPN O
activation NOUN O
and CCONJ O
thus ADV O
GVBD PROPN B-AC
, PUNCT O
and CCONJ O
Mos1 PROPN O
synthesis NOUN O
to PART O
initiate VERB O
the DET O
MAPK PROPN O
cascade NOUN O
. PUNCT O
; PUNCT O
Br PROPN B-AC
- PUNCT B-AC
cAMP NOUN B-AC
, PUNCT O
bromoadenosine NOUN B-LF
3′,5′-cyclic NOUN I-LF
monophosphate NOUN I-LF
; PUNCT O
GST PROPN B-AC
, PUNCT O
Glutathione PROPN B-LF
- PUNCT I-LF
S PROPN I-LF
- PUNCT I-LF
Transferase PROPN I-LF
; PUNCT O
GVBD PROPN B-AC
, PUNCT O
germinal ADJ B-LF
vesicle NOUN I-LF
breakdown NOUN I-LF
; PUNCT O
MIH PROPN B-AC
, PUNCT O
maturation NOUN B-LF
- PUNCT I-LF
inducing VERB I-LF
hormone NOUN I-LF
; PUNCT O
MIHR PROPN B-AC
, PUNCT O
MIH PROPN B-LF
receptor NOUN I-LF
; PUNCT O
PKA PROPN B-AC
, PUNCT O
protein NOUN O
kinase NOUN O
A. NOUN O

As ADP O
part NOUN O
of ADP O
quality NOUN B-LF
control NOUN I-LF
( PUNCT O
QC PROPN B-AC
) PUNCT O
, NOUN O
the DET O
following ADJ O
were AUX O
excluded VERB O
: PUNCT O
SNP NOUN B-AC
markers NOUN O
with ADP O
unknown ADJ O
genomic ADJ O
position NOUN O
, NOUN O
located VERB O
on ADP O
sex NOUN O
chromosomes NOUN O
, NOUN O
monomorphic ADJ O
and CCONJ O
markers NOUN O
with ADP O
minor ADJ O
allele NOUN O
frequency NOUN O
( PUNCT O
MAF PROPN O
) PUNCT O
bellow NOUN O
0.05 NUM O
, NOUN O
call NOUN O
rate NOUN O
bellow NOUN O
90 NUM O
% NOUN O
, NOUN O
with ADP O
excess ADJ O
markers NOUN O
heterozygous ADJ O
genotypes NOUN O
and CCONJ O
those PRON O
who PRON O
had VERB O
a DET O
mean ADJ O
intensity NOUN O
of ADP O
the DET O
low ADJ O
cluster NOUN O
. PUNCT O

Typhimurium NOUN O
, PUNCT O
S. PROPN O
enterica NOUN O
serovar NOUN O
Typhimurium NOUN O
; PUNCT O
SCFA PROPN B-AC
, PUNCT O
short ADJ B-LF
- PUNCT I-LF
chain NOUN I-LF
fatty ADJ I-LF
acid NOUN I-LF
. PUNCT O

The DET O
terms NOUN O
Positive PROPN B-LF
Percent NOUN I-LF
Agreement PROPN I-LF
( PUNCT O
PPA PROPN B-AC
) PUNCT O
and CCONJ O
Negative PROPN B-LF
Percent NOUN I-LF
Agreement PROPN I-LF
( PUNCT O
NPA PROPN B-AC
) PUNCT O
should AUX O
be AUX O
used VERB O
in ADP O
place NOUN O
of ADP O
Sensitivity PROPN O
and CCONJ O
Specificity PROPN O
, PUNCT O
respectively ADV O
, PUNCT O
when SCONJ O
the DET O
comparator NOUN O
is AUX O
known VERB O
to PART O
contain VERB O
uncertainty NOUN O
. PUNCT O

The DET O
model NOUN O
's PART O
primary ADJ O
outcome NOUN O
measure NOUN O
is AUX O
the DET O
cost NOUN O
per ADP O
disability NOUN B-LF
adjusted VERB I-LF
life NOUN I-LF
year NOUN I-LF
( PUNCT O
DALY PROPN B-AC
) PUNCT O
averted VERB O
. PUNCT O

Mice NOUN O
were AUX O
exposed VERB O
to ADP O
blue ADJ O
and CCONJ O
green ADJ O
light NOUN O
stimuli NOUN O
and CCONJ O
after ADP O
30 NUM O
min NOUN O
SCN PROPN B-AC
and CCONJ O
VLPO PROPN B-AC
were AUX O
collected VERB O
for ADP O
gene NOUN O
expression NOUN O
analysis NOUN O
using VERB O
quantitative ADJ B-LF
PCR NOUN I-LF
( PUNCT O
qPCR NOUN B-AC
) PUNCT O
. PUNCT O
Consistent ADJ O
with ADP O
our PRON O
previous ADJ O
findings NOUN O
( PUNCT O
Fig NOUN O
4A NUM O
) PUNCT O
, PUNCT O
we PRON O
found VERB O
that SCONJ O
blue ADJ O
light NOUN O
produced VERB O
a DET O
larger ADJ O
Fos PROPN O
induction NOUN O
in ADP O
the DET O
SCN PROPN B-AC
than ADP O
green ADJ O
light NOUN O
. PUNCT O

C NOUN B-AC
- PUNCT B-AC
value NOUN B-AC
; PUNCT O
DNA NOUN B-LF
content NOUN I-LF
value NOUN I-LF
; PUNCT O
CW PROPN B-AC
, PUNCT O
critical ADJ B-LF
weight NOUN I-LF
; PUNCT O
L2 NOUN B-AC
, PUNCT O
second ADJ B-LF
instar NOUN I-LF
; PUNCT O
L3 PROPN B-AC
, PUNCT O
third ADJ B-LF
instar NOUN I-LF
; PUNCT O
PG PROPN B-AC
, PUNCT O
prothoracic ADJ B-LF
gland NOUN I-LF
; PUNCT O
TOR PROPN B-AC
, PUNCT O
target NOUN B-LF
of ADP I-LF
rapamycin NOUN I-LF
. PUNCT O

HT NOUN O
, PUNCT O
heterozygous ADJ O
; PUNCT O
ns NOUN B-AC
, PUNCT O
not PART B-LF
significant ADJ I-LF
; PUNCT O
P NOUN O
, PUNCT O
postnatal ADJ O
day NOUN O
; PUNCT O
WT NOUN B-AC
, PUNCT O
wild ADJ B-LF
type NOUN I-LF
. PUNCT O

fH NOUN B-AC
= VERB O
heart NOUN B-LF
rate NOUN I-LF
; PUNCT O
PI NOUN B-AC
= VERB O
pulse NOUN B-LF
interval NOUN I-LF
; PUNCT O
Ps NOUN B-AC
= VERB O
systolic ADJ O
pressure NOUN O
; PUNCT O
Pd NOUN B-AC
= VERB O
diastolic ADJ O
pressure NOUN O
; PUNCT O
Pm NOUN B-AC
= VERB O
mean ADJ B-LF
arterial ADJ I-LF
pressure NOUN I-LF
; PUNCT O
Pp NOUN B-AC
= VERB O
pulse NOUN B-LF
pressure NOUN I-LF
; PUNCT O
Gop NOUN B-AC
= VERB O
baroreflex ADJ B-LF
gain NOUN I-LF
at ADP I-LF
the DET I-LF
operating NOUN I-LF
point NOUN I-LF
; PUNCT O
BEI NOUN B-AC
= VERB O
baroreflex ADJ B-LF
effectiveness NOUN I-LF
index NOUN I-LF
; PUNCT O
τ NOUN O
= VERB O
pressure NOUN O
decay NOUN O
time NOUN O
constant ADJ O
; PUNCT O
τ NOUN O
/ SYM O
PI NOUN B-AC
= VERB O
ratio NOUN O
between ADP O
pressure NOUN O
decay NOUN O
time NOUN O
constant ADJ O
and CCONJ O
pulse NOUN B-LF
interval NOUN I-LF
; PUNCT O
OPF NOUN B-AC
= VERB O
oscillatory ADJ B-LF
power NOUN I-LF
fraction NOUN I-LF
. PUNCT O

This DET O
study NOUN O
is AUX O
a DET O
secondary ADJ O
data NOUN O
analysis NOUN O
of ADP O
the DET O
2015–16 NUM O
Myanmar PROPN B-LF
Demographic PROPN I-LF
and CCONJ I-LF
Health PROPN I-LF
Survey PROPN I-LF
( PUNCT O
MDHS PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
is AUX O
a DET O
cross ADJ O
- PUNCT O
sectional ADJ O
nationally ADV O
representative ADJ O
population NOUN O
- PUNCT O
based VERB O
survey NOUN O
. PUNCT O

In ADP O
this DET O
assay NOUN O
, PUNCT O
a DET O
premixed VERB O
Annexin PROPN O
V PROPN O
in ADP O
combination NOUN O
with ADP O
a DET O
dead ADJ O
cell NOUN O
marker NOUN O
, PUNCT O
7 NUM B-LF
- PUNCT I-LF
amino NOUN I-LF
actinomycin NOUN I-LF
( PUNCT O
7 NUM B-AC
- PUNCT B-AC
AAD PROPN B-AC
) PUNCT O
is AUX O
used VERB O
. PUNCT O

The DET O
source NOUN O
population NOUN O
were AUX O
all PRON O
records NOUN O
children NOUN O
aged ADJ O
6–59 NUM O
months NOUN O
with ADP O
SAM PROPN B-AC
admitted VERB O
to ADP O
Therapeutic PROPN B-LF
Feeding PROPN I-LF
Center PROPN I-LF
( PUNCT O
TFC PROPN B-AC
) PUNCT O
at ADP O
the DET O
UOGCSH PROPN B-AC
from ADP O
January1/2014 NUM O
to ADP O
December PROPN O
30/ NUM O
2016 NUM O
. PUNCT O

Human ADJ O
monocytes NOUN O
are AUX O
broadly ADV O
classified VERB O
into ADP O
three NUM O
phenotypically ADV O
and CCONJ O
functionally ADV O
distinct ADJ O
subsets NOUN O
, PUNCT O
based VERB O
on ADP O
CD14 PROPN O
and CCONJ O
CD16 PROPN O
expression NOUN O
; PUNCT O
which PRON O
likely ADV O
represent VERB O
different ADJ O
stages NOUN O
of ADP O
maturity NOUN O
and CCONJ O
differentiation NOUN O
[ PUNCT O
9 NUM O
] PUNCT O
. PUNCT O
‘ PUNCT O
Classical ADJ O
’ PUNCT O
CD14high NOUN O
/ SYM O
CD16- NOUN O
monocytes NOUN O
( PUNCT O
comprising VERB O
~80 NUM O
% NOUN O
of ADP O
peripheral ADJ O
blood NOUN O
monocytes NOUN O
) PUNCT O
express VERB O
high ADJ O
levels NOUN O
of ADP O
chemokine NOUN B-LF
( PUNCT I-LF
C PROPN I-LF
- PUNCT I-LF
C PROPN I-LF
motif NOUN I-LF
) PUNCT I-LF
receptor NOUN I-LF
( PUNCT O
CCR)2 PROPN B-AC
and CCONJ O
exhibit VERB O
strong ADJ O
phagocytic ADJ O
capacity NOUN O
. PUNCT O

ALS PROPN B-AC
, PUNCT O
amyotrophic ADJ B-LF
lateral ADJ I-LF
sclerosis NOUN I-LF
; PUNCT O
CI NOUN O
, PUNCT O
confidence NOUN O
interval NOUN O
; PUNCT O
HR NOUN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT O
LOS NOUN O
, PUNCT O
length NOUN O
of ADP O
stay NOUN O
; PUNCT O
NA NOUN O
, PUNCT O
not PART O
applicable ADJ O
; PUNCT O
NDD NOUN B-AC
, PUNCT O
neurodegenerative ADJ B-LF
disease NOUN I-LF
; PUNCT O
PD NOUN B-AC
, PUNCT O
Parkinson PROPN B-LF
disease NOUN I-LF
; PUNCT O
TBI PROPN B-AC
, PUNCT O
traumatic ADJ B-LF
brain NOUN I-LF
injury NOUN I-LF
. PUNCT O

SD NOUN B-AC
: PUNCT O
standard ADJ B-LF
deviation NOUN I-LF
. PUNCT O

DM NOUN B-AC
: PUNCT O
diabetes NOUN B-LF
mellitus NOUN I-LF
, PUNCT O
GERD NOUN B-AC
: PUNCT O
gastroesophageal ADJ O
reflux NOUN O
disease NOUN O

We PRON O
classified VERB O
each DET O
EOC PROPN B-AC
into ADP O
five NUM O
groups NOUN O
based VERB O
on ADP O
their PRON O
troponin NOUN O
pattern NOUN O
and CCONJ O
primary ADJ O
/ SYM O
secondary ADJ O
discharge NOUN O
diagnoses NOUN O
to PART O
maximally ADV O
align VERB O
with ADP O
the DET O
Fourth PROPN O
Universal PROPN O
Definition PROPN O
of ADP O
MI PROPN B-AC
. PUNCT O
Episodes NOUN B-LF
of ADP I-LF
care NOUN I-LF
rather ADV O
than ADP O
individual NOUN O
patient NOUN O
- PUNCT O
level NOUN O
analysis NOUN O
was AUX O
chosen VERB O
as SCONJ O
pattern NOUN O
characterisation NOUN O
of ADP O
hs NOUN O
- PUNCT O
cTnT NOUN O
allows VERB O
for ADP O
dynamic ADJ O
risk NOUN O
assessment NOUN O
which PRON O
is AUX O
expected VERB O
to PART O
vary VERB O
in ADP O
an DET O
individual NOUN O
over ADP O
time NOUN O
. PUNCT O

NCBI PROPN B-AC
, PUNCT O
National PROPN B-LF
Center PROPN I-LF
for ADP I-LF
Biotechnology PROPN I-LF
Information PROPN I-LF
; PUNCT O
TOM PROPN B-AC
, PUNCT O
translocase NOUN B-LF
of ADP I-LF
the DET I-LF
outer ADJ I-LF
membrane NOUN I-LF
; PUNCT O
TvTom PROPN O
, PUNCT O
T. NOUN O
vaginalis NOUN O
TOM PROPN B-AC
. PUNCT O

Carriers NOUN O
were AUX O
repeatedly ADV O
outcrossed VERB O
until SCONJ O
recombinants NOUN O
were AUX O
obtained VERB O
separating VERB O
pedigree NOUN O
M PROPN O
insertion NOUN O
03A-0033 NUM O
, PUNCT O
in ADP O
the DET O
mouse NOUN B-LF
carbonic ADJ I-LF
anhydrase NOUN I-LF
10 NUM I-LF
gene NOUN I-LF
( PUNCT O
Car10 PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
pedigree NOUN O
V NOUN O
insertion NOUN O
03A-0063 NUM O
, PUNCT O
in ADP O
the DET O
mouse NOUN O
myosin NOUN B-LF
heavy ADJ I-LF
chain NOUN I-LF
2 NUM I-LF
gene NOUN I-LF
( PUNCT O
Myh2 PROPN B-AC
) PUNCT O
( PUNCT O
Table PROPN O
S1 NOUN O
) PUNCT O
, PUNCT O
from ADP O
all DET O
other ADJ O
insertions NOUN O
and CCONJ O
the DET O
donor NOUN O
site NOUN O
( PUNCT O
unpublished ADJ O
data NOUN O
) PUNCT O
. PUNCT O

First ADV O
, PUNCT O
arguments NOUN O
and CCONJ O
frames NOUN O
were AUX O
developed VERB O
to PART O
challenge VERB O
the DET O
FCTC PROPN B-AC
, PUNCT O
including VERB O
: PUNCT O
claiming VERB O
there PRON O
would AUX O
be AUX O
damaging ADJ O
economic ADJ O
consequences NOUN O
; PUNCT O
depicting VERB O
tobacco NOUN O
control NOUN O
as ADP O
an DET O
agenda NOUN O
promoted VERB O
by ADP O
high ADJ O
- PUNCT O
income NOUN O
countries NOUN O
; PUNCT O
alleging VERB O
the DET O
treaty NOUN O
conflicted VERB O
with ADP O
trade NOUN O
agreements NOUN O
, PUNCT O
“ PUNCT O
good ADJ O
governance NOUN O
, PUNCT O
” PUNCT O
and CCONJ O
national ADJ O
sovereignty NOUN O
; PUNCT O
questioning VERB O
WHO PROPN B-AC
's PART O
mandate NOUN O
; PUNCT O
claiming VERB O
the DET O
FCTC PROPN B-AC
would AUX O
set VERB O
a DET O
precedent NOUN O
for ADP O
issues NOUN O
beyond ADP O
tobacco NOUN O
; PUNCT O
and CCONJ O
presenting VERB O
corporate ADJ B-LF
social ADJ I-LF
responsibility NOUN I-LF
( PUNCT O
CSR PROPN B-AC
) PUNCT O
as ADP O
an DET O
alternative NOUN O
. PUNCT O

Photoactivatable ADJ B-LF
and CCONJ I-LF
clickable ADJ I-LF
sphingosine NOUN I-LF
( PUNCT O
pacSph NOUN B-AC
, PUNCT O
S1 PROPN O
Fig PROPN O
) PUNCT O
is AUX O
a DET O
promising ADJ O
new ADJ O
addition NOUN O
to PART O
the DET O
tool NOUN O
set NOUN O
, PUNCT O
as SCONJ O
it PRON O
enables VERB O
to PART O
specifically ADV O
crosslink VERB O
sphingolipids NOUN O
to PART O
interacting VERB O
proteins NOUN O
via ADP O
the DET O
diazirine NOUN O
group NOUN O
and CCONJ O
provides VERB O
an DET O
additional ADJ O
click NOUN O
functionality NOUN O
to PART O
allow VERB O
for ADP O
detection NOUN O
by ADP O
adding VERB O
a DET O
fluorophore NOUN O
or CCONJ O
enrichment NOUN O
by ADP O
adding VERB O
a DET O
tag NOUN O
for ADP O
affinity NOUN O
purification NOUN O
[ PUNCT O
11 NUM O
, PUNCT O
15 NUM O
] PUNCT O
. PUNCT O

UUO PROPN B-AC
induced VERB O
monocyte NOUN O
renal ADJ O
infiltration NOUN O
, PUNCT O
tubular ADJ O
cell NOUN O
apoptosis NOUN O
, PUNCT O
tubular ADJ O
atrophy NOUN O
, PUNCT O
interstitial ADJ O
fibrosis NOUN O
and CCONJ O
overexpression NOUN O
of ADP O
TGFβ NOUN B-AC
, PUNCT O
Renin PROPN B-LF
mRNA NOUN I-LF
( PUNCT O
RENmRNA NOUN B-AC
) PUNCT O
, PUNCT O
increase NOUN O
of ADP O
Renin PROPN O
, PUNCT O
Angiotensin NOUN B-LF
II NUM I-LF
( PUNCT O
AII PROPN B-AC
) PUNCT O
and CCONJ O
aldosterone NOUN O
serum NOUN O
levels NOUN O
. PUNCT O

Among ADP O
the DET O
most ADV O
important ADJ O
chloroplast NOUN O
antioxidative ADJ O
enzymes NOUN O
are AUX O
Cu NOUN O
, PUNCT O
Zn NOUN O
- PUNCT O
superoxide NOUN B-LF
dismutase NOUN I-LF
( PUNCT O
Cu NOUN O
, PUNCT O
Zn NOUN O
- PUNCT O
SOD PROPN B-AC
) PUNCT O
, PUNCT O
ascorbate NOUN B-LF
peroxidase NOUN I-LF
( PUNCT O
APX PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
glutathione NOUN B-LF
reductase NOUN I-LF
( PUNCT O
GR NOUN B-AC
) PUNCT O
, PUNCT O
which PRON O
are AUX O
frequently ADV O
complemented VERB O
with ADP O
the DET O
extra ADJ O
chloroplast NOUN O
action NOUN O
of ADP O
catalase NOUN B-LF
( PUNCT O
CAT PROPN B-AC
) PUNCT O
, PUNCT O
when SCONJ O
H2O2 NOUN B-AC
diffuses VERB O
to ADP O
out ADP O
of ADP O
chloroplast NOUN O
. PUNCT O

For ADP O
example NOUN O
, PUNCT O
B. PROPN O
anthracis PROPN O
PGN PROPN B-AC
has VERB O
a DET O
stem NOUN O
peptide NOUN O
consisting VERB O
of ADP O
three NUM O
amino NOUN O
acids NOUN O
including VERB O
diaminopimelic NOUN B-LF
acid NOUN I-LF
( PUNCT O
DAP PROPN B-AC
) PUNCT O
[ X O
3 NUM O
] PUNCT O
, PUNCT O
while SCONJ O
S. PROPN O
aureus PROPN O
contains VERB O
a DET O
lysine NOUN O
residue NOUN O
in ADP O
the DET O
DAP PROPN B-AC
position NOUN O
and CCONJ O
has VERB O
a DET O
pentapeptide NOUN O
stem NOUN O
linked VERB O
by ADP O
a DET O
pentaglycyl NOUN O
bridge NOUN O
[ X O
8 NUM O
] PUNCT O
. PUNCT O

Compared VERB O
to PART O
vaginal ADJ O
delivery NOUN O
, PUNCT O
cesarean ADJ O
delivery NOUN O
was AUX O
associated VERB O
with ADP O
decreased VERB O
risk NOUN O
of ADP O
urinary ADJ O
incontinence NOUN O
, PUNCT O
odds NOUN B-LF
ratio NOUN I-LF
( PUNCT O
OR NOUN B-AC
) PUNCT O
0.56 NUM O
( PUNCT O
95 NUM O
% NOUN O
CI NOUN O
0.47 NUM O
to PART O
0.66 NUM O
; PUNCT O
n NOUN O
= SYM O
58,900 NUM O
; PUNCT O
8 NUM O
studies NOUN O
) PUNCT O
and CCONJ O
pelvic ADJ O
organ NOUN O
prolapse NOUN O
( PUNCT O
OR NOUN B-AC
0.29 NUM O
, PUNCT O
0.17 NUM O
to PART O
0.51 NUM O
; PUNCT O
n NOUN O
= SYM O
39,208 NUM O
; PUNCT O
2 NUM O
studies NOUN O
) PUNCT O
. PUNCT O

The DET O
term NOUN O
adaptive ADJ B-LF
neuro ADJ I-LF
- ADJ I-LF
fuzzy ADJ I-LF
inference NOUN I-LF
system NOUN I-LF
( PUNCT O
ANFIS PROPN B-AC
) PUNCT O
was AUX O
first ADV O
introduced VERB O
by ADP O
Jang PROPN O
in ADP O
1993 NUM O
. PUNCT O

Extracellular ADJ B-LF
signal NOUN I-LF
- PUNCT I-LF
regulated VERB I-LF
kinase NOUN I-LF
( PUNCT O
ERK PROPN B-AC
) PUNCT O
stands VERB O
out ADP O
as ADP O
important ADJ O
positive ADJ O
[ X O
2,3][4,5 NUM O
] X O
and CCONJ O
negative ADJ O
[ X O
6 X O
] X O
regulator NOUN O
of ADP O
the DET O
adipocyte NOUN O
differentiation NOUN O
process NOUN O
. PUNCT O

Sample NOUN O
size NOUN O
calculations NOUN O
for ADP O
reliability NOUN O
measures NOUN O
indicate VERB O
that SCONJ O
50–100 NUM O
persons NOUN O
are AUX O
recommended VERB O
when SCONJ O
two NUM O
raters NOUN O
are AUX O
used VERB O
, PUNCT O
and CCONJ O
aiming VERB O
for ADP O
the DET O
precision NOUN O
of ADP O
CIs NOUN B-AC
( PUNCT O
confidence NOUN B-LF
intervals NOUN I-LF
) PUNCT O
of ADP O
+ NOUN O
/- NOUN O
0.1 NUM O
and CCONJ O
0.2 NUM O
, PUNCT O
respectively ADV O
. PUNCT O

The DET O
recent ADJ O
whole ADJ O
- PUNCT O
genome NOUN O
scan NOUN O
for ADP O
breast NOUN O
cancer NOUN O
has AUX O
revealed VERB O
the DET O
FGFR2 PROPN B-AC
( PUNCT O
fibroblast NOUN B-LF
growth NOUN I-LF
factor NOUN I-LF
receptor NOUN I-LF
2 NUM I-LF
) PUNCT O
gene NOUN O
as ADP O
a DET O
locus NOUN O
associated VERB O
with ADP O
a DET O
small ADJ O
, PUNCT O
but CCONJ O
highly ADV O
significant ADJ O
, PUNCT O
increase NOUN O
in ADP O
the DET O
risk NOUN O
of ADP O
developing VERB O
breast NOUN O
cancer NOUN O
. PUNCT O

CSP PROPN B-AC
, PUNCT O
carotid ADJ B-LF
sinus NOUN I-LF
pressure NOUN I-LF
( PUNCT O
mmHg NOUN O
) PUNCT O
; PUNCT O
AP NOUN B-AC
, PUNCT O
arterial ADJ B-LF
pressure NOUN I-LF
( PUNCT O
mmHg NOUN O
) PUNCT O
; PUNCT O
SNA NOUN B-AC
, PUNCT O
sympathetic ADJ B-LF
nerve NOUN I-LF
activity NOUN I-LF
( PUNCT O
a.u NOUN O
. PUNCT O
) PUNCT O
; PUNCT O
HR NOUN B-AC
, PUNCT O
heart NOUN B-LF
rate NOUN I-LF
( PUNCT O
bpm NOUN O
) PUNCT O
; PUNCT O
SVR NOUN B-AC
, PUNCT O
systemic ADJ B-LF
vascular ADJ I-LF
resistance NOUN I-LF
( PUNCT O
mmHg•min NOUN O
/ SYM O
ml NOUN O
) PUNCT O
; PUNCT O
CO NOUN B-AC
, PUNCT O
cardiac ADJ B-LF
output NOUN I-LF
( PUNCT O
ml NOUN O
/ SYM O
min NOUN O
) PUNCT O
. PUNCT O

On ADP O
the DET O
contrary NOUN O
, PUNCT O
the DET O
single ADJ B-LF
- PUNCT I-LF
molecule NOUN I-LF
force NOUN I-LF
spectroscopy NOUN I-LF
( PUNCT O
SMFS PROPN B-AC
) PUNCT O
approach NOUN O
reported VERB O
here ADV O
describes VERB O
, PUNCT O
by ADP O
design NOUN O
, PUNCT O
the DET O
conformational ADJ O
equilibrium NOUN O
of ADP O
the DET O
monomeric ADJ O
form NOUN O
. PUNCT O

Relative ADJ O
kinase NOUN O
frequencies NOUN O
across ADP O
the DET O
48 NUM O
species NOUN O
were AUX O
calculated VERB O
for ADP O
the DET O
CDK NOUN B-AC
family NOUN O
, PUNCT O
and CCONJ O
motif NOUN O
enrichments NOUN O
were AUX O
calculated VERB O
for ADP O
its PRON O
cognate ADJ O
substrate NOUN O
motif NOUN O
( PUNCT O
S NOUN B-AC
/ SYM B-AC
T NOUN B-AC
- PUNCT O
P NOUN O
- PUNCT O
x NOUN O
- PUNCT O
K PROPN O
) PUNCT O
. PUNCT O
CDK NOUN B-AC
, PUNCT O
Cyclin NOUN B-LF
- PUNCT I-LF
Dependent PROPN I-LF
Kinase PROPN I-LF
. PUNCT O

For ADP O
the DET O
2 NUM O
COVID-19 PROPN B-AC
survivors NOUN O
not PART O
undergoing VERB O
cardiac ADJ B-LF
magnetic ADJ I-LF
resonance NOUN I-LF
imaging NOUN I-LF
, PUNCT O
one NUM O
was AUX O
implanted VERB O
with ADP O
CMR NOUN B-AC
- PUNCT O
noncompatible ADJ O
pacemaker NOUN O
and CCONJ O
the DET O
other ADJ O
refused VERB O
to ADP O
participate VERB O
due ADP O
to ADP O
claustrophobia NOUN O
. PUNCT O

Total ADJ O
RNA NOUN O
from ADP O
tumor NOUN O
cells NOUN O
was AUX O
isolated VERB O
by ADP O
an DET O
RNA NOUN O
extraction NOUN O
kit NOUN O
( PUNCT O
Qiagen PROPN O
) PUNCT O
and CCONJ O
cDNA NOUN O
synthesis NOUN O
and CCONJ O
real ADJ O
- PUNCT O
time NOUN O
( PUNCT O
RT)-PCR NOUN O
were AUX O
performed VERB O
using VERB O
the DET O
first ADJ O
strand NOUN O
cDNA NOUN O
synthesis NOUN O
kit NOUN O
( PUNCT O
Fermentas PROPN O
) PUNCT O
and CCONJ O
SYBR PROPN O
Green PROPN O
Master PROPN O
Mix PROPN O
kit NOUN O
( PUNCT O
Roche PROPN O
) PUNCT O
applying VERB O
specific ADJ O
primers NOUN O
( PUNCT O
Life PROPN O
Technologies PROPN O
) PUNCT O
for ADP O
human ADJ O
leucine NOUN B-LF
- PUNCT I-LF
rich ADJ I-LF
- PUNCT I-LF
repeat NOUN I-LF
- PUNCT I-LF
containing VERB I-LF
G NOUN I-LF
- PUNCT I-LF
protein NOUN I-LF
- PUNCT I-LF
coupled VERB I-LF
- PUNCT I-LF
receptor NOUN I-LF
5 NUM I-LF
( PUNCT O
Lgr5 PROPN B-AC
) PUNCT O
and CCONJ O
superoxide NOUN B-LF
dismutase NOUN I-LF
1 NUM I-LF
( PUNCT O
SOD1 PROPN B-AC
) PUNCT O
. PUNCT O

Face NOUN O
- VERB O
to PART O
- VERB O
face NOUN O
interviews NOUN O
were AUX O
carried VERB O
out ADP O
with ADP O
the DET O
heads NOUN O
of ADP O
premises NOUN O
, PUNCT O
health NOUN O
leaders NOUN O
or CCONJ O
responsible ADJ O
persons NOUN O
of ADP O
pest NOUN O
control NOUN O
or CCONJ O
any DET O
other ADJ O
occupant NOUN O
of ADP O
the DET O
premises NOUN O
who PRON O
knew VERB O
about ADP O
their PRON O
program NOUN O
of ADP O
EFE PROPN B-AC
. PUNCT O
The DET O
interviewers NOUN O
used VERB O
a DET O
pre VERB O
- VERB O
tested VERB O
questionnaire NOUN O
to PART O
obtain VERB O
information NOUN O
on ADP O
interviewees NOUN O
’ PART O
knowledge NOUN O
about ADP O
mosquitoes NOUN O
[ PUNCT O
27 NUM O
] PUNCT O
, PUNCT O
mosquito NOUN O
infestation NOUN O
in ADP O
their PRON O
premises NOUN O
and CCONJ O
management NOUN O
efforts NOUN O
, PUNCT O
guidance NOUN O
and CCONJ O
supervision NOUN O
of ADP O
PHC PROPN B-LF
System PROPN I-LF
( PUNCT O
PHCS PROPN B-AC
) PUNCT O
on ADP O
mosquito NOUN O
management NOUN O
. PUNCT O

The DET O
SID PROPN B-AC
and CCONJ O
SEDD PROPN B-AC
are AUX O
made VERB O
available ADJ O
through ADP O
the DET O
Agency PROPN B-LF
for ADP I-LF
Healthcare PROPN I-LF
Research PROPN I-LF
and CCONJ I-LF
Quality PROPN I-LF
’s PART O
( PUNCT O
AHRQ PROPN B-AC
) PUNCT O
Healthcare PROPN O
Cost PROPN O
and CCONJ O
Utilization PROPN O
Project PROPN O
, PUNCT O
and CCONJ O
include VERB O
administrative ADJ O
claims NOUN O
data NOUN O
submitted VERB O
by ADP O
all DET O
participating VERB O
hospitals NOUN O
in ADP O
New PROPN O
York PROPN O
State PROPN O
. PUNCT O

PM2.5 NUM B-AC
, PUNCT O
fine ADJ B-LF
particulate ADJ I-LF
matter NOUN I-LF
( PUNCT O
particulate ADJ O
matter NOUN O
with ADP O
a DET O
diameter NOUN O
of ADP O
< ADP O
2.5 NUM O
μm NOUN O
) PUNCT O

F PROPN B-AC
- PUNCT B-AC
BCA PROPN B-AC
, PUNCT O
Fsp1 PROPN O
- PUNCT O
Cre;Ctnnb1exon PROPN O
3 NUM O
fl/+ NOUN O
; PUNCT O
FSP1 PROPN B-AC
, PUNCT O
fibroblast NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
protein-1 NOUN I-LF
; PUNCT O
HE PROPN B-AC
, PUNCT O
hematoxylin NOUN B-LF
– SYM I-LF
eosin NOUN I-LF
; PUNCT O
WAT PROPN B-AC
, PUNCT O
white ADJ B-LF
adipose ADJ I-LF
tissue NOUN I-LF
. PUNCT O

The DET O
clinicopathological ADJ O
significance NOUN O
of ADP O
altered VERB O
SWI PROPN B-AC
/ SYM B-AC
SNF PROPN B-AC
complex NOUN O
has AUX O
not PART O
been AUX O
well ADV O
evaluated VERB O
in ADP O
gastric ADJ B-LF
cancer NOUN I-LF
( PUNCT O
GC PROPN B-AC
) PUNCT O
. PUNCT O
We PRON O
examined VERB O
SMARCA2 PROPN O
, PUNCT O
SMARCA4 PROPN O
, PUNCT O
SMARCB1 PROPN O
and CCONJ O
ARID1A PROPN O
expression NOUN O
by ADP O
immunohistochemistry NOUN O
in ADP O
1224 NUM O
surgically ADV O
resected VERB O
GCs NOUN B-AC
with ADP O
subtyping VERB O
into ADP O
Epstein PROPN B-LF
- ADJ I-LF
Barr PROPN I-LF
virus NOUN I-LF
( PUNCT O
EBV PROPN B-AC
) PUNCT O
, PUNCT O
microsatellite NOUN B-LF
instability NOUN I-LF
( PUNCT O
MSI PROPN B-AC
) PUNCT O
and CCONJ O
non ADJ O
- ADJ O
EBV PROPN B-AC
/ SYM O
MSI PROPN B-AC
Lauren PROPN O
histotypes NOUN O
. PUNCT O

SEEG PROPN B-AC
, PUNCT O
stereotactic ADJ B-LF
electroencephalography NOUN I-LF
. PUNCT O

It PRON O
is AUX O
also ADV O
the DET O
only ADJ O
scoring NOUN O
system NOUN O
that PRON O
takes VERB O
diffuse ADJ B-LF
axonal ADJ I-LF
injury NOUN I-LF
( PUNCT O
DAI PROPN B-AC
) PUNCT O
visible ADJ O
on ADP O
CT PROPN B-AC
into ADP O
consideration NOUN O
[ PUNCT O
9 NUM O
] PUNCT O
. PUNCT O

Ninety NUM O
- PUNCT O
six NUM O
patients NOUN O
undergoing VERB O
mechanical ADJ O
ventilation NOUN O
in ADP O
the DET O
surgical ADJ O
intensive ADJ B-LF
care NOUN I-LF
unit NOUN I-LF
( PUNCT O
ICU PROPN B-AC
) PUNCT O
were AUX O
enrolled VERB O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
BD PROPN O
, PUNCT O
Becton PROPN O
Dickinson PROPN O
; PUNCT O
BrdU PROPN B-AC
, PUNCT O
5 NUM B-LF
- PUNCT I-LF
bromodeoxyuridine NOUN I-LF
; PUNCT O
Cdc PROPN B-AC
, PUNCT O
cell NOUN B-LF
division NOUN I-LF
cycle NOUN I-LF
; PUNCT O
Cdk PROPN O
, PUNCT O
cell NOUN O
cycle NOUN O
dependent ADJ O
kinase NOUN O
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent NOUN I-LF
protein NOUN I-LF
; PUNCT O
hMTBP PROPN B-AC
, PUNCT O
human ADJ B-LF
MTBP PROPN I-LF
; PUNCT O
IgG PROPN O
, PUNCT O
immunoglobulin NOUN O
; PUNCT O
Mcm PROPN B-AC
, PUNCT O
minichromosome NOUN B-LF
maintenance NOUN I-LF
; PUNCT O
Med PROPN O
, PUNCT O
mediator NOUN O
of ADP O
transcription NOUN O
; PUNCT O
MTBP PROPN B-AC
, PUNCT O
Mdm2 NOUN B-LF
binding VERB I-LF
protein NOUN I-LF
; PUNCT O
Sld PROPN O
, PUNCT O
synthetic NOUN O
lethal ADJ O
with ADP O
Dpb11 PROPN B-AC
; PUNCT O
TICRR PROPN O
, PUNCT O
TopBP1 PROPN B-AC
interacting VERB O
checkpoint NOUN O
and CCONJ O
replication NOUN O
regulator NOUN O
; PUNCT O
TopBP1 PROPN B-AC
, PUNCT O
Topoisomerase NOUN O
II NUM O
binding VERB O
protein NOUN O
. PUNCT O

BPD NOUN B-AC
= PUNCT O
borderline ADJ B-LF
personality NOUN I-LF
disorder NOUN I-LF
, PUNCT O
SAD NOUN B-AC
= PUNCT O
social ADJ B-LF
anxiety NOUN I-LF
disorder NOUN I-LF
/ SYM O
anxious ADJ O
avoidant ADJ O
personality NOUN O
disorder NOUN O
, PUNCT O
HC NOUN B-AC
= PUNCT O
healthy ADJ B-LF
control NOUN I-LF
participants NOUN I-LF
, PUNCT O
DD NOUN B-AC
= PUNCT O
current ADJ O
major ADJ O
depressive ADJ O
episode NOUN O
or CCONJ O
dysthymia NOUN O
. PUNCT O

The DET O
digestion NOUN O
of ADP O
AX PROPN B-AC
using VERB O
a DET O
specific ADJ O
endoxylanase NOUN O
results VERB O
in ADP O
the DET O
release NOUN O
of ADP O
a DET O
range NOUN O
of ADP O
AXOS PROPN B-AC
, PUNCT O
the DET O
total ADJ O
amount NOUN O
of ADP O
which PRON O
( PUNCT O
TOTAL PROPN B-LF
AXOS PROPN I-LF
) PUNCT O
reflects VERB O
the DET O
content NOUN O
of ADP O
total ADJ O
AX PROPN B-AC
. PUNCT O
The DET O
Aegilops PROPN O
species NOUN O
had VERB O
lower ADJ O
TOTAL PROPN B-LF
AXOS PROPN I-LF
than ADP O
wheat NOUN O
during ADP O
drought NOUN O
stress NOUN O
( PUNCT O
Table PROPN O
4 NUM O
) PUNCT O
, PUNCT O
as SCONJ O
also ADV O
found VERB O
for ADP O
the DET O
TOT PROPN B-AC
- PUNCT O
pentosan NOUN O
content NOUN O
, PUNCT O
but CCONJ O
no DET O
differences NOUN O
were AUX O
observed VERB O
in ADP O
the DET O
TOTAL PROPN B-LF
AXOS PROPN I-LF
contents NOUN O
of ADP O
the DET O
addition NOUN O
lines NOUN O
( PUNCT O
Table PROPN O
3 NUM O
, PUNCT O
S4 NUM O
Fig PROPN O
) PUNCT O
. PUNCT O

GPAT2 PROPN O
knockdown NOUN O
was AUX O
routinely ADV O
assessed VERB O
by ADP O
quantitative ADJ B-LF
real ADJ I-LF
- PUNCT I-LF
time NOUN I-LF
PCR NOUN I-LF
( PUNCT O
qRT NOUN B-AC
- PUNCT B-AC
PCR NOUN B-AC
) PUNCT O
[ X O
8 NUM O
] X O
and CCONJ O
Western ADJ O
blot NOUN O
. PUNCT O

The DET O
accurate ADJ O
detection NOUN O
of ADP O
severe ADJ B-LF
acute ADJ I-LF
respiratory ADJ I-LF
syndrome NOUN I-LF
– PUNCT I-LF
coronavirus NOUN I-LF
2 NUM I-LF
( PUNCT O
SARS PROPN B-AC
- PUNCT B-AC
CoV-2 PROPN B-AC
) PUNCT O
is AUX O
essential ADJ O
for ADP O
the DET O
diagnosis NOUN O
of ADP O
coronavirus NOUN B-LF
disease NOUN I-LF
2019 NUM I-LF
( PUNCT O
COVID-19 PROPN B-AC
) PUNCT O
. PUNCT O

E10.5 NUM B-AC
, PUNCT O
embryonic ADJ B-LF
day NOUN I-LF
10.5 NUM I-LF
; PUNCT O
E11.5 NUM B-AC
, PUNCT O
embryonic ADJ B-LF
day NOUN I-LF
11.5 NUM I-LF
; PUNCT O
E12.5 NUM B-AC
, PUNCT O
embryonic ADJ B-LF
day NOUN I-LF
12.5 NUM I-LF
; PUNCT O
EP PROPN O
, PUNCT O
embryo NOUN O
proper ADJ O
; PUNCT O
IF PROPN B-AC
, PUNCT O
immunofluorescence NOUN B-LF
; PUNCT O
PECAM PROPN O
, PUNCT O
platelet NOUN O
endothelial ADJ O
cell NOUN O
adhesion NOUN O
molecule NOUN O
; PUNCT O
p NOUN O
- PUNCT O
RIPK3 NOUN O
, PUNCT O
phosphorylated VERB O
RIPK3 NOUN O
; PUNCT O
RIPK1 PROPN B-AC
, PUNCT O
receptor NOUN B-LF
interacting VERB I-LF
serine NOUN I-LF
/ SYM I-LF
threonine NOUN I-LF
kinase NOUN I-LF
1 NUM I-LF
; PUNCT O
YS PROPN O
, PUNCT O
yolk NOUN O
sac NOUN O
. PUNCT O

CaM PROPN B-AC
, PUNCT O
calmodulin NOUN B-LF
; PUNCT O
HDX NOUN B-AC
- PUNCT B-AC
MS PROPN B-AC
, PUNCT O
hydrogen NOUN B-LF
/ SYM I-LF
deuterium NOUN I-LF
exchange NOUN I-LF
mass NOUN I-LF
spectrometry NOUN I-LF
. PUNCT O

The DET O
most ADV O
recent ADJ O
data NOUN O
collected VERB O
during ADP O
the DET O
Demographic PROPN B-LF
and CCONJ I-LF
Health PROPN I-LF
Surveys PROPN I-LF
( PUNCT O
DHS PROPN B-AC
) PUNCT O
conducted VERB O
between ADP O
2010 NUM O
and CCONJ O
2018 NUM O
in ADP O
African ADJ O
countries NOUN O
was AUX O
used VERB O
. PUNCT O

Feedback NOUN O
pathways NOUN O
involving VERB O
enzymes NOUN O
such ADJ O
as ADP O
riboflavin NOUN O
kinase NOUN O
( PUNCT O
EC PROPN O
2.7.1.26 NUM O
) PUNCT O
and CCONJ O
FAD PROPN B-AC
( PUNCT O
flavin NOUN B-LF
adenine NOUN I-LF
dinucleotide NOUN I-LF
) PUNCT O
diphosphatase NOUN O
( PUNCT O
EC PROPN O
3.6.1.18 NUM O
) PUNCT O
probably ADV O
regulate VERB O
intracellular ADJ O
FMN PROPN B-AC
to PART O
titrate VERB O
endogenous ADJ O
flavoproteins NOUN O
and CCONJ O
miniSOG NOUN B-AC
[ PUNCT O
25 NUM O
] PUNCT O
. PUNCT O

The DET O
MAbs NOUN B-AC
2F5 NUM O
and CCONJ O
4E10 PROPN O
, PUNCT O
which PRON O
target VERB O
conserved VERB O
epitopes NOUN O
within ADP O
the DET O
membrane NOUN B-LF
- PUNCT I-LF
proximal ADJ I-LF
external ADJ I-LF
region NOUN I-LF
( PUNCT O
MPER PROPN B-AC
) PUNCT O
of ADP O
gp41 NOUN O
, PUNCT O
are AUX O
unusually ADV O
hydrophobic ADJ O
and CCONJ O
may AUX O
even ADV O
be AUX O
autoreactive ADJ O
[ PUNCT O
12,13 NUM O
] PUNCT O
. PUNCT O

Three NUM O
classes NOUN O
of ADP O
protocols NOUN O
for ADP O
DR PROPN B-AC
have AUX O
been AUX O
used VERB O
to PART O
extend VERB O
lifespan NOUN O
in ADP O
C. PROPN O
elegans NOUN O
: PUNCT O
“ PUNCT O
axenic ADJ O
” PUNCT O
or CCONJ O
“ PUNCT O
dietary ADJ O
deprivation NOUN O
” PUNCT O
dietary ADJ B-LF
restriction NOUN I-LF
with ADP O
no DET O
bacteria NOUN O
[ PUNCT O
16],[17],[5 NUM O
. PUNCT O
] PUNCT O
, PUNCT O
genetic ADJ O
reduction NOUN O
of ADP O
feeding NOUN O
rate NOUN O
( PUNCT O
e.g. X O
, PUNCT O
by ADP O
mutation NOUN O
in ADP O
the DET O
eat-2 NOUN O
gene NOUN O
[ PUNCT O
18 NUM O
] PUNCT O
) PUNCT O
, PUNCT O
or CCONJ O
optimized VERB O
bacterial ADJ O
dilution NOUN O
in ADP O
liquid NOUN O
media NOUN O
( PUNCT O
bDR PROPN B-AC
) PUNCT O
[ PUNCT O
19],[3],[8 NUM O
] PUNCT O
. PUNCT O

RNA2 NOUN O
also ADV O
encodes VERB O
protein NOUN O
2b NUM O
, PUNCT O
in ADP O
a DET O
second ADJ O
open ADJ B-LF
reading NOUN I-LF
frame NOUN I-LF
( PUNCT O
ORF PROPN B-AC
) PUNCT O
overlapping VERB O
that PRON O
for ADP O
protein NOUN O
2a NUM O
, PUNCT O
which PRON O
is AUX O
a DET O
suppressor NOUN O
of ADP O
the DET O
post ADJ O
- PUNCT O
transcriptional ADJ O
gene NOUN O
- PUNCT O
silencing VERB O
defense NOUN O
of ADP O
the DET O
host NOUN O
plant NOUN O
. PUNCT O

In ADP O
the DET O
presence NOUN O
of ADP O
Nrf2 PROPN B-AC
activators NOUN O
( PUNCT O
oxidative ADJ O
stress NOUN O
, PUNCT O
some DET O
chemicals NOUN O
including VERB O
phytochemicals NOUN O
) PUNCT O
, PUNCT O
the DET O
Nrf2 PROPN B-AC
dissociates VERB O
from ADP O
Keap1 PROPN O
and CCONJ O
translocates VERB O
in ADP O
to ADP O
the DET O
nucleus NOUN O
where SCONJ O
it PRON O
assembles VERB O
to ADP O
a DET O
cis ADJ O
- PUNCT O
acting VERB O
regulatory ADJ O
sequences NOUN O
called VERB O
antioxidant ADJ O
response NOUN O
element NOUN O
( PUNCT O
ARE PROPN O
) PUNCT O
or CCONJ O
electrophile ADJ B-LF
- PUNCT I-LF
response NOUN I-LF
element NOUN I-LF
( PUNCT O
EpRE PROPN B-AC
) PUNCT O
, PUNCT O
located VERB O
in ADP O
the DET O
promoter NOUN O
region NOUN O
of ADP O
genes NOUN O
encoding VERB O
various ADJ O
antioxidant ADJ O
and CCONJ O
phase NOUN O
2 NUM O
detoxifying VERB O
enzymes NOUN O
and CCONJ O
resulting VERB O
in ADP O
their PRON O
expression NOUN O
[ PUNCT O
8,10 NUM O
] PUNCT O
. PUNCT O

Open ADJ O
transforaminal ADJ B-LF
lumbar NOUN I-LF
interbody NOUN I-LF
fusion NOUN I-LF
( PUNCT O
TLIF PROPN B-AC
) PUNCT O
and CCONJ O
posterior ADJ B-LF
lumbar NOUN I-LF
interbody NOUN I-LF
fusion NOUN I-LF
( PUNCT O
PLIF PROPN B-AC
) PUNCT O
are AUX O
two NUM O
widely ADV O
used VERB O
techniques NOUN O
for ADP O
spinal ADJ O
fusion NOUN O
. PUNCT O

To PART O
generate VERB O
a DET O
comprehensive ADJ O
, PUNCT O
deeply ADV O
sampled VERB O
C. PROPN O
elegans PROPN O
proteome NOUN O
database NOUN O
that PRON O
can AUX O
be AUX O
used VERB O
for ADP O
quantitative ADJ O
proteome NOUN O
analysis NOUN O
, PUNCT O
we PRON O
applied VERB O
subcellular ADJ O
and CCONJ O
biochemical ADJ O
fractionation NOUN O
methods NOUN O
to ADP O
the DET O
worm NOUN O
proteins NOUN O
, PUNCT O
performed VERB O
tryptic NOUN O
digests NOUN O
, PUNCT O
separated VERB O
the DET O
resulting VERB O
peptides NOUN O
using VERB O
a DET O
variety NOUN O
of ADP O
techniques NOUN O
, PUNCT O
and CCONJ O
identified VERB O
the DET O
peptides NOUN O
by ADP O
mass NOUN B-LF
spectrometry NOUN I-LF
( PUNCT O
MS NOUN B-AC
) PUNCT O
. PUNCT O
This PRON O
resulted VERB O
in ADP O
a DET O
unique ADJ O
global ADJ O
view NOUN O
on ADP O
the DET O
expression NOUN O
status NOUN O
of ADP O
the DET O
C. PROPN O
elegans PROPN O
proteome NOUN O
. PUNCT O

To ADP O
our PRON O
knowledge NOUN O
, PUNCT O
this DET O
study NOUN O
is AUX O
the DET O
first ADJ O
to ADP O
apply VERB O
a DET O
multistage NOUN O
sampling NOUN O
- PUNCT O
based VERB O
approach NOUN O
to ADP O
generating VERB O
provincially ADV O
representative ADJ O
mortality NOUN O
rates NOUN O
for ADP O
HIV PROPN O
programs NOUN O
in ADP O
low- ADJ B-LF
and CCONJ I-LF
middle ADJ I-LF
- PUNCT I-LF
income NOUN I-LF
countries NOUN I-LF
( PUNCT O
LMICs PROPN B-AC
) PUNCT O
. PUNCT O

GLP-1R NOUN B-AC
, PUNCT O
glucagon NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
peptide-1 NOUN I-LF
receptor NOUN I-LF
. PUNCT O

Educational ADJ O
attainment NOUN O
was AUX O
also ADV O
defined VERB O
by ADP O
asking VERB O
“ PUNCT O
Which PRON O
of ADP O
the DET O
following ADJ O
qualifications NOUN O
do AUX O
you PRON O
have VERB O
? PUNCT O
” PUNCT O
for ADP O
which PRON O
participants NOUN O
could AUX O
select VERB O
more ADJ O
than ADP O
one NUM O
option NOUN O
, PUNCT O
including VERB O
“ PUNCT O
College PROPN O
or CCONJ O
University PROPN O
degree NOUN O
, PUNCT O
” PUNCT O
“ PUNCT O
A NOUN O
levels NOUN O
/ SYM O
AS PROPN O
levels NOUN O
or CCONJ O
equivalent NOUN O
, PUNCT O
” PUNCT O
“ PUNCT O
O PROPN O
levels NOUN O
/ SYM O
GCSEs NOUN B-AC
or CCONJ O
equivalent NOUN O
, PUNCT O
” PUNCT O
“ PUNCT O
CESs NOUN O
or CCONJ O
equivalent NOUN O
, PUNCT O
” PUNCT O
“ PUNCT O
NVQ PROPN O
or CCONJ O
HND PROPN O
or CCONJ O
HNC PROPN O
or CCONJ O
equivalent NOUN O
, PUNCT O
” PUNCT O
“ PUNCT O
Other ADJ O
professional ADJ O
qualifications NOUN O
, PUNCT O
e.g. X O
, PUNCT O
nursing NOUN O
, PUNCT O
teaching NOUN O
, PUNCT O
” PUNCT O
or CCONJ O
“ PUNCT O
None PROPN O
of ADP O
the DET O
above ADJ O
. PUNCT O
” PUNCT O
Participant NOUN O
responses NOUN O
were AUX O
coded VERB O
into ADP O
categorical ADJ O
variables NOUN O
for ADP O
degree NOUN O
holders NOUN O
, PUNCT O
as ADP O
well ADV O
as ADP O
for ADP O
those PRON O
who PRON O
had AUX O
completed VERB O
advanced ADJ O
- PUNCT O
level NOUN O
studies NOUN O
( PUNCT O
A NOUN O
- PUNCT O
level NOUN O
) PUNCT O
or CCONJ O
had AUX O
obtained VERB O
their PRON O
general ADJ B-LF
certificate NOUN I-LF
of ADP I-LF
secondary ADJ I-LF
education NOUN I-LF
( PUNCT O
GCSE PROPN B-AC
) PUNCT O
. PUNCT O

The DET O
underlying VERB O
data NOUN O
for ADP O
this DET O
figure NOUN O
can AUX O
be AUX O
found VERB O
in ADP O
S1 PROPN O
Data PROPN O
. PUNCT O
cko NOUN B-AC
, PUNCT O
conditional ADJ B-LF
knockout NOUN I-LF
; PUNCT O
HSA PROPN B-AC
, PUNCT O
human ADJ B-LF
alpha NOUN I-LF
- PUNCT I-LF
skeletal ADJ I-LF
actin NOUN I-LF
; PUNCT O
IL PROPN B-AC
, PUNCT O
interleukin NOUN B-LF
; PUNCT O
KO PROPN B-AC
, PUNCT O
knockout NOUN B-LF
; PUNCT O
Lmna PROPN O
, PUNCT O
lamin NOUN O
A PROPN O
/ SYM O
C PROPN O
gene NOUN O
; PUNCT O
LmnaHSA PROPN B-AC
- PUNCT B-AC
cko NOUN B-AC
, PUNCT O
skeletal ADJ B-LF
muscle NOUN I-LF
– PUNCT I-LF
specific ADJ I-LF
Lmna PROPN I-LF
- PUNCT I-LF
cko NOUN I-LF
mice NOUN I-LF
; PUNCT O
mo PROPN B-AC
, PUNCT O
months NOUN B-LF
old ADJ I-LF
. PUNCT O

We PRON O
applied VERB O
CFA PROPN B-AC
, PUNCT O
bifactor ADJ O
CFA PROPN B-AC
, PUNCT O
exploratory ADJ B-LF
structural ADJ I-LF
equation NOUN I-LF
modeling NOUN I-LF
( PUNCT O
ESEM PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
bifactor ADJ O
ESEM PROPN B-AC
to ADP O
the DET O
AFM-2 PROPN B-AC
( PUNCT O
Study NOUN O
1 NUM O
) PUNCT O
, PUNCT O
ATQ PROPN B-AC
- PUNCT B-AC
P PROPN B-AC
( PUNCT O
Study NOUN O
2 NUM O
) PUNCT O
, PUNCT O
and CCONJ O
PHQ-9 PROPN B-AC
( PUNCT O
Study NOUN O
4 NUM O
) PUNCT O
. PUNCT O

NTBC PROPN B-AC
, PUNCT O
nitisinone PROPN B-LF
. PUNCT O

The DET O
gross ADJ O
pictures NOUN O
of ADP O
the DET O
aorta NOUN O
after ADP O
laparotomy NOUN O
at ADP O
day-28 NUM O
explant NOUN O
showed VERB O
increased VERB O
external ADJ O
diameter NOUN O
and CCONJ O
significant ADJ O
inflammation NOUN O
in ADP O
the DET O
PPE PROPN O
group NOUN O
( PUNCT O
Fig NOUN O
4A NUM O
) PUNCT O
. PUNCT O
The DET O
outer ADJ O
diameter NOUN O
of ADP O
the DET O
aneurysmal ADJ O
aortas NOUN O
increased VERB O
significantly ADV O
above ADP O
~ NUM O
95 NUM O
% NOUN O
at ADP O
day-14 NUM O
and CCONJ O
up ADP O
to ADP O
~200 NUM O
% NOUN O
at ADP O
day-28 NUM O
in ADP O
the DET O
PPE PROPN O
treated VERB O
mice NOUN O
( PUNCT O
Fig NOUN O
4B NUM O
) PUNCT O
. PUNCT O
The DET O
histology NOUN O
at ADP O
14 NUM O
- PUNCT O
day NOUN O
explant NOUN O
confirmed VERB O
aneurysmal ADJ O
expansion NOUN O
and CCONJ O
significantly ADV O
degraded VERB O
elastic ADJ O
lamina NOUN O
in ADP O
PPE PROPN O
treated VERB O
group NOUN O
( PUNCT O
Fig NOUN O
4C NUM O
) PUNCT O
. PUNCT O
While SCONJ O
external ADJ O
diameter NOUN O
continued VERB O
to ADP O
increase VERB O
in ADP O
untreated ADJ O
group NOUN O
, PUNCT O
in ADP O
EL PROPN B-AC
- PUNCT B-AC
PGG PROPN B-AC
- PUNCT B-AC
NPs PROPN B-AC
group NOUN O
, PUNCT O
the DET O
external ADJ O
diameter NOUN O
significantly ADV O
decreased VERB O
below ADP O
~ NUM O
45 NUM O
% NOUN O
in ADP O
comparison NOUN O
to ADP O
PPE PROPN O
treated VERB O
group NOUN O
at ADP O
day-28 NUM O
( PUNCT O
Fig NOUN O
4B NUM O
) PUNCT O
. PUNCT O
These DET O
data NOUN O
suggest VERB O
that SCONJ O
site NOUN O
- PUNCT O
specific ADJ O
delivery NOUN O
of ADP O
PGG PROPN B-AC
with ADP O
nanoparticles NOUN B-LF
reverses VERB O
already ADV O
developed VERB O
aneurysm NOUN O
and CCONJ O
restores VERB O
arterial ADJ O
mechanics NOUN O
[ PUNCT O
12–15 NUM O
] PUNCT O
. PUNCT O

ACh NOUN B-AC
: PUNCT O
acetylcholine NOUN B-LF
, PUNCT O
BMM NOUN B-AC
: PUNCT O
bone NOUN B-LF
marrow NOUN I-LF
- PUNCT I-LF
derived VERB I-LF
macrophage NOUN I-LF
, PUNCT O
CIA NOUN B-AC
: PUNCT O
collagen NOUN B-LF
- PUNCT I-LF
induced VERB I-LF
arthritis NOUN I-LF
, PUNCT O
NA NOUN B-AC
: PUNCT O
noradrenaline NOUN B-LF
, PUNCT O
SEM NOUN B-AC
: PUNCT O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean NOUN I-LF
, PUNCT O
p.i NOUN O
. PUNCT O
: PUNCT O
post NOUN O
- PUNCT O
immunization NOUN O
, PUNCT O
TRAP NOUN B-AC
: PUNCT O
tartrate NOUN B-LF
- PUNCT I-LF
resistant ADJ I-LF
acid NOUN I-LF
phosphatase NOUN I-LF

AZT PROPN B-AC
, PUNCT O
azidothymidine NOUN B-LF
; PUNCT O
BPS PROPN O
, PUNCT O
iron NOUN O
starvation NOUN O
- PUNCT O
FeSO NOUN O
; PUNCT O
CCCP PROPN O
, PUNCT O
Carbonyl NOUN O
cyanide NOUN O
3 NUM O
- PUNCT O
chlorophenylhydrazone NOUN O
; PUNCT O
EGCG PROPN O
, PUNCT O
epigallocatechin NOUN O
gallate NOUN O
; PUNCT O
MDR PROPN B-AC
, PUNCT O
multidrug NOUN B-LF
- PUNCT I-LF
resistant ADJ I-LF
; PUNCT O
MIC PROPN B-AC
, PUNCT O
minimum ADJ B-LF
inhibitory ADJ I-LF
concentration NOUN I-LF
; PUNCT O
MMS PROPN O
, PUNCT O
methyl NOUN O
methanesulfonate NOUN O
; PUNCT O
PMS PROPN O
, PUNCT O
phenazine NOUN O
methosulfate NOUN O

Therefore ADV O
, PUNCT O
the DET O
aim NOUN O
of ADP O
this DET O
study NOUN O
was AUX O
to PART O
research VERB O
the DET O
antitumor ADJ O
effects NOUN O
of ADP O
the DET O
ginsenoside NOUN B-LF
Rk3 PROPN I-LF
on ADP O
esophageal ADJ O
cancer NOUN O
cell NOUN O
lines NOUN O
and CCONJ O
to PART O
investigate VERB O
the DET O
potential ADJ O
molecular ADJ O
mechanisms NOUN O
by ADP O
which PRON O
it PRON O
activates VERB O
apoptosis NOUN O
and CCONJ O
autophagy NOUN O
both CCONJ O
in ADP O
vitro ADJ O
and CCONJ O
in ADP O
vivo ADJ O
. PUNCT O

The DET O
6 NUM O
immune NOUN O
- PUNCT O
mediated VERB O
diseases NOUN O
are AUX O
Crohn PROPN B-LF
disease NOUN I-LF
( PUNCT O
CD PROPN B-AC
) PUNCT O
, PUNCT O
ulcerative ADJ B-LF
colitis NOUN I-LF
( PUNCT O
UC PROPN B-AC
) PUNCT O
, PUNCT O
type NOUN B-LF
1 NUM I-LF
diabetes NOUN I-LF
( PUNCT O
T1D PROPN B-AC
) PUNCT O
, PUNCT O
rheumatoid ADJ B-LF
arthritis NOUN I-LF
( PUNCT O
RA PROPN B-AC
) PUNCT O
, PUNCT O
celiac ADJ B-LF
disease NOUN I-LF
( PUNCT O
CeD PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
psoriasis NOUN O
( PUNCT O
PSOR PROPN B-AC
) PUNCT O
. PUNCT O
The DET O
levels NOUN O
of ADP O
−log10(p NOUN O
) PUNCT O
> SYM O
0 NUM O
, PUNCT O
−log10(p NOUN O
) PUNCT O
> SYM O
1 NUM O
, PUNCT O
and CCONJ O
−log10(p NOUN O
) PUNCT O
> SYM O
2 NUM O
correspond VERB O
to ADP O
p NOUN O
< SYM O
1 NUM O
, PUNCT O
p NOUN O
< SYM O
0.1 NUM O
, PUNCT O
and CCONJ O
p NOUN O
< SYM O
0.01 NUM O
, PUNCT O
respectively ADV O
. PUNCT O

Apc PROPN B-AC
, PUNCT O
adenomatous ADJ O
polyposis NOUN O
coli NOUN O
; PUNCT O
IL-22 NOUN B-AC
, PUNCT O
interleukin-22 NOUN B-LF
; PUNCT O
pSTAT3 NOUN B-AC
, PUNCT O
phosphorylated VERB B-LF
STAT3 PROPN I-LF
; PUNCT O
STAT3 PROPN B-AC
, PUNCT O
signal NOUN B-LF
transducer NOUN I-LF
and CCONJ I-LF
activator NOUN I-LF
of ADP I-LF
transcription NOUN I-LF
3 NUM I-LF
; PUNCT O
Tyr705 PROPN O
, PUNCT O
Tyrosine PROPN O
705 NUM O
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

Although SCONJ O
WHO PROPN O
recommends VERB O
viral ADJ B-LF
load NOUN I-LF
( PUNCT O
VL PROPN B-AC
) PUNCT O
monitoring NOUN O
for ADP O
those PRON O
on ADP O
antiretroviral ADJ B-LF
therapy NOUN I-LF
( PUNCT O
ART PROPN B-AC
) PUNCT O
, PUNCT O
availability NOUN O
in ADP O
low ADJ O
- PUNCT O
income NOUN O
countries NOUN O
remains VERB O
limited ADJ O
. PUNCT O

( PUNCT O
A PRON O
) PUNCT O
A PRON O
drift NOUN O
- PUNCT O
corrected VERB O
cryo NOUN B-AC
- PUNCT B-AC
EM PROPN B-AC
micrograph NOUN O
of ADP O
the DET O
dOrai PROPN B-AC
- PUNCT O
P288L PROPN O
channel NOUN O
. PUNCT O
( PUNCT O
B NOUN O
) PUNCT O
Ctffind PROPN O
showed VERB O
Thon NOUN O
rings NOUN O
in ADP O
the DET O
Fourier PROPN O
spectrum NOUN O
of ADP O
the DET O
image NOUN O
in ADP O
panel NOUN O
A. PUNCT O
( PUNCT O
C NOUN O
) PUNCT O
Selected VERB O
two NUM O
- PUNCT O
dimensional ADJ O
class NOUN O
averages NOUN O
of ADP O
the DET O
dOrai PROPN B-AC
- PUNCT O
P288L PROPN O
channel NOUN O
. PUNCT O
( PUNCT O
D NOUN O
) PUNCT O
The DET O
gold ADJ O
- PUNCT O
standard NOUN O
FSC PROPN O
coefficient NOUN O
curve NOUN O
of ADP O
the DET O
final ADJ O
reconstruction NOUN O
showed VERB O
an DET O
overall ADJ O
resolution NOUN O
of ADP O
5.7 NUM O
Å. PUNCT O
( PUNCT O
E NOUN O
) PUNCT O
Local ADJ O
resolution NOUN O
estimation NOUN O
by ADP O
ResMap PROPN O
( PUNCT O
http://resmap.sourceforge.net/ X O
) PUNCT O
. PUNCT O
cryo NOUN B-AC
- PUNCT B-AC
EM PROPN B-AC
, PUNCT O
cryo NOUN O
- PUNCT O
electron NOUN O
microscopy NOUN O
; PUNCT O
dOrai PROPN B-AC
, PUNCT O
Drosophila PROPN B-LF
melanogaster NOUN I-LF
Orai PROPN I-LF
; PUNCT O
FSC PROPN O
, PUNCT O
Fourier PROPN O
shell NOUN O
correlation NOUN O
. PUNCT O

AH NOUN B-AC
– PUNCT O
arterial ADJ B-LF
hypertension NOUN I-LF
, PUNCT O
BA PROPN B-AC
– PUNCT O
bronchial NOUN B-LF
asthma NOUN I-LF
, PUNCT O
CK NOUN B-AC
– PUNCT O
creatine NOUN B-LF
kinase NOUN I-LF
, PUNCT O
CHD PROPN B-AC
– PUNCT O
coronary ADJ B-LF
heart NOUN I-LF
disease NOUN I-LF
, PUNCT O
CHF PROPN B-AC
- NOUN O
congestive ADJ B-LF
heart NOUN I-LF
failure NOUN I-LF
, PUNCT O
CKD PROPN B-AC
– PUNCT O
chronic ADJ B-LF
kidney NOUN I-LF
disease NOUN I-LF
, PUNCT O
CRP- PROPN B-AC
C NOUN B-LF
- NOUN I-LF
reactive ADJ I-LF
protein NOUN I-LF
, PUNCT O
CT PROPN B-AC
computer NOUN B-LF
tomography NOUN I-LF
, PUNCT O
DBP PROPN B-AC
– PUNCT O
diastolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
, PUNCT O
DM PROPN B-AC
– PUNCT O
Diabetes PROPN B-LF
Mellitus PROPN I-LF
type NOUN I-LF
2 NUM I-LF
, PUNCT O
ESR PROPN B-AC
– PUNCT O
erythrocytes NOUN B-LF
sedimentation NOUN I-LF
rate NOUN I-LF
, PUNCT O
Hb NOUN B-AC
– PUNCT O
hemoglobin NOUN B-LF
, PUNCT O
HR NOUN B-AC
– PUNCT O
heart NOUN B-LF
rate NOUN I-LF
, PUNCT O
MI PROPN B-AC
– PUNCT O
myocardial NOUN B-LF
infarction NOUN I-LF
, PUNCT O
SBP PROPN B-AC
– PUNCT O
systolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
, PUNCT O
WBC PROPN B-AC
– PUNCT O
white NOUN B-LF
blood NOUN I-LF
count NOUN I-LF
. PUNCT O

Underlying VERB O
data NOUN O
can AUX O
be AUX O
found VERB O
at ADP O
https://osf.io/cbjq6/. X O
fMRI NOUN B-AC
, PUNCT O
functional ADJ B-LF
MRI NOUN I-LF
; PUNCT O
EVC PROPN B-AC
, PUNCT O
early ADJ B-LF
visual ADJ I-LF
cortex NOUN I-LF
; PUNCT O
std NOUN B-AC
, PUNCT O
standard ADJ B-LF
deviation NOUN I-LF
. PUNCT O

Abbreviations NOUN O
: PUNCT O
D PROPN B-AC
- PUNCT B-AC
dimer NOUN B-AC
, PUNCT O
Dimerized VERB B-LF
plasmin NOUN I-LF
fragment NOUN I-LF
D PROPN I-LF
; PUNCT O
CRP PROPN B-AC
, PUNCT O
C NOUN B-LF
- PUNCT I-LF
reactive ADJ I-LF
protein NOUN I-LF
; PUNCT O
PCT PROPN B-AC
, PUNCT O
procalcitonin NOUN B-LF
; PUNCT O
LDH PROPN B-AC
, PUNCT O
lactate NOUN B-LF
dehydrogenase NOUN I-LF
; PUNCT O
WBC PROPN B-AC
, PUNCT O
white ADJ B-LF
blood NOUN I-LF
cell NOUN I-LF
; PUNCT O
CK PROPN B-AC
, PUNCT O
creatinine NOUN B-LF
kinase NOUN I-LF
; PUNCT O
AST PROPN B-AC
, PUNCT O
aspartate NOUN B-LF
aminotransferase NOUN I-LF
; PUNCT O
CI NOUN O
, PUNCT O
confidential ADJ O
interval NOUN O
. PUNCT O

Hazard NOUN B-LF
ratios NOUN I-LF
( PUNCT O
HRs NOUN B-AC
) PUNCT O
with ADP O
95 NUM O
% NOUN O
CIs NOUN O
were AUX O
estimated VERB O
using VERB O
multivariable ADJ O
Cox PROPN O
regression NOUN O
to PART O
examine VERB O
mortality NOUN O
during ADP O
the DET O
study NOUN O
period NOUN O
. PUNCT O

In ADP O
line NOUN O
with ADP O
this DET O
observation NOUN O
, PUNCT O
we PRON O
found VERB O
that SCONJ O
simultaneous ADJ O
inhibition NOUN O
of ADP O
the DET O
2 NUM O
major ADJ O
receptors NOUN O
of ADP O
PGE2 PROPN B-AC
— PUNCT O
prostaglandin NOUN B-LF
E2 PROPN I-LF
receptor NOUN O
2 NUM O
( PUNCT O
EP2 PROPN O
) PUNCT O
and CCONJ O
EP4 PROPN O
— PUNCT O
on ADP O
moDCs NOUN B-AC
reduced VERB O
the DET O
ability NOUN O
of ADP O
SEAΔα-1 NOUN O
/ SYM O
ω-1 NOUN B-AC
– PUNCT O
stimulated VERB O
moDCs NOUN B-AC
to PART O
induce VERB O
a DET O
Th2 NOUN B-AC
response NOUN O
( PUNCT O
Fig PROPN O
2C NUM O
) PUNCT O
. PUNCT O
These DET O
results NOUN O
collectively ADV O
demonstrate VERB O
that SCONJ O
SEA PROPN B-AC
, PUNCT O
independently ADV O
of ADP O
ω-1 NOUN B-AC
, PUNCT O
promotes VERB O
PGE2 PROPN B-AC
synthesis NOUN O
by ADP O
moDCs NOUN B-AC
, PUNCT O
which PRON O
subsequently ADV O
, PUNCT O
in ADP O
an DET O
autocrine ADJ O
manner NOUN O
, PUNCT O
conditions VERB O
these DET O
cells NOUN O
to PART O
acquire VERB O
a DET O
Th2 NOUN B-AC
- PUNCT O
polarizing VERB O
phenotype NOUN O
. PUNCT O

SD PROPN B-AC
, PUNCT O
standard ADJ B-LF
deviation NOUN I-LF
; PUNCT O
BCS PROPN B-AC
, PUNCT O
body NOUN B-LF
condition NOUN I-LF
score NOUN I-LF
; PUNCT O
BOAS PROPN B-AC
, PUNCT O
brachycephalic ADJ B-LF
obstructive ADJ I-LF
airway NOUN I-LF
syndrome NOUN I-LF
; PUNCT O
NA PROPN O
, PUNCT O
data NOUN O
not PART O
available ADJ O
. PUNCT O

The DET O
nuclear ADJ O
signal NOUN O
obtained VERB O
from ADP O
the DET B-AC
resulting VERB O
image NOUN O
was AUX O
measured VERB O
to PART O
obtain VERB O
the DET B-AC
raw ADJ B-LF
integrated VERB I-LF
density NOUN I-LF
( PUNCT O
RID NOUN B-AC
) PUNCT O
. PUNCT O
The DET O
nuclear ADJ O
area NOUN O
was AUX O
obtained VERB O
from ADP O
the DET B-AC
mask NOUN O
. PUNCT O

Several ADJ O
markers NOUN O
have AUX O
been AUX O
individually ADV O
used VERB O
to PART O
identify VERB O
CMs PROPN B-AC
( PUNCT O
signal ADJ B-LF
regulatory ADJ I-LF
protein NOUN I-LF
alpha NOUN I-LF
[ X O
SIRPα PROPN B-AC
] PUNCT O
, PUNCT O
vascular ADJ B-LF
cell NOUN I-LF
adhesion NOUN I-LF
molecule NOUN I-LF
1 NUM I-LF
[ X O
VCAM-1 PROPN B-AC
] PUNCT O
, PUNCT O
Caveolin-3 NOUN B-LF
[ X O
Cav3 X B-AC
] PUNCT O
[ X O
11–13 NUM O
] PUNCT O
) PUNCT O
and CCONJ O
their PRON O
putative ADJ O
adult NOUN O
PRGs NOUN B-AC
( PUNCT O
stem NOUN B-LF
cells NOUN I-LF
antigen NOUN I-LF
1 NUM I-LF
[ X O
Sca-1 NOUN B-AC
] PUNCT O
[ X O
14,15 NUM O
] PUNCT O
, PUNCT O
proto ADJ O
- X O
oncogene ADJ O
receptor NOUN O
tyrosine NOUN O
kinase NOUN O
[ X O
c NOUN O
- X O
kit X O
] PUNCT O
[ X O
16 NUM O
] PUNCT O
) PUNCT O
, PUNCT O
FBs NOUN B-AC
( PUNCT O
discoidin NOUN B-LF
domain NOUN I-LF
receptor NOUN I-LF
family NOUN I-LF
member NOUN I-LF
2 NUM I-LF
[ X O
Ddr2 PROPN B-AC
] PUNCT O
, PUNCT O
thymus NOUN B-LF
cell NOUN I-LF
antigen NOUN I-LF
1 NUM I-LF
[ X O
Thy1 PROPN B-AC
] PUNCT O
[ X O
17,18 NUM O
] PUNCT O
) PUNCT O
, PUNCT O
SMCs NOUN B-AC
( PUNCT O
platelet NOUN B-LF
derived VERB I-LF
growth NOUN I-LF
factor NOUN I-LF
receptor NOUN I-LF
beta NOUN I-LF
[ X O
PDGFrβ PROPN B-AC
] PUNCT O
[ X O
19 NUM O
] PUNCT O
) PUNCT O
and CCONJ O
endothelial ADJ B-LF
cells NOUN I-LF
( PUNCT O
ECs PROPN B-AC
, PUNCT O
platelet NOUN B-LF
/ SYM I-LF
endothelial ADJ I-LF
cell NOUN I-LF
adhesion NOUN I-LF
molecule NOUN I-LF
1 NUM I-LF
[ X O
PECAM-1 PROPN B-AC
] PUNCT O
[ X O
20 NUM O
] PUNCT O
) PUNCT O
. PUNCT O

These DET O
enzymes NOUN O
catalyze VERB O
the DET O
hydroxylation NOUN O
of ADP O
proteins NOUN O
, PUNCT O
in ADP O
a DET O
manner NOUN O
that PRON O
is AUX O
dependent ADJ O
on ADP O
the DET O
availability NOUN O
of ADP O
molecular ADJ B-LF
oxygen NOUN I-LF
( PUNCT O
O2 NOUN B-AC
) PUNCT O
. PUNCT O

One NUM O
of ADP O
the DET O
most ADV O
studied ADJ O
mechanisms NOUN O
of ADP O
activation NOUN O
of ADP O
NRF2 PROPN B-AC
are AUX O
the DET O
redox NOUN O
stressors NOUN O
, PUNCT O
which PRON O
put VERB O
the DET O
Kelch PROPN B-LF
- PUNCT I-LF
like ADJ I-LF
ECH NOUN I-LF
- PUNCT I-LF
associated VERB I-LF
protein NOUN I-LF
1 NUM I-LF
( PUNCT O
KEAP1 PROPN B-AC
) PUNCT O
out ADP O
of ADP O
play NOUN O
. PUNCT O

B NOUN O
= PUNCT O
Regression NOUN O
coefficients NOUN O
, PUNCT O
OR NOUN B-AC
= PUNCT O
Odds NOUN B-LF
ratio NOUN I-LF
, PUNCT O
BPMH NOUN B-AC
= PUNCT O
Best ADJ B-LF
possible ADJ I-LF
medication NOUN I-LF
history NOUN I-LF

A DET O
health NOUN O
facility NOUN O
- ADJ O
based VERB O
cross ADJ O
- ADJ O
sectional ADJ O
study NOUN O
was AUX O
conducted VERB O
on ADP O
403 NUM O
neonates NOUN O
admitted VERB O
to ADP O
the DET O
neonatal ADJ B-LF
intensive ADJ I-LF
care NOUN I-LF
units NOUN I-LF
( PUNCT O
NICUs PROPN B-AC
) PUNCT O
from ADP O
January PROPN O
2015 NUM O
to ADP O
December PROPN O
2019 NUM O
. PUNCT O

Effective ADJ O
treatment NOUN O
is AUX O
complicated VERB O
by ADP O
multidrug NOUN B-LF
- PUNCT I-LF
resistant ADJ I-LF
TB PROPN B-AC
( PUNCT O
MDR PROPN B-AC
TB PROPN B-AC
) PUNCT O
strains NOUN O
that PRON O
respond VERB O
only ADV O
to ADP O
second ADJ O
- PUNCT O
line NOUN O
drugs NOUN O
. PUNCT O

In ADP O
concordance NOUN O
, PUNCT O
p38δFab PROPN O
- PUNCT O
KO PROPN O
presented VERB O
reduced VERB O
energy NOUN O
expenditure NOUN O
, PUNCT O
whole ADJ O
- PUNCT O
body NOUN O
temperature NOUN O
, PUNCT O
and CCONJ O
decreased VERB O
BAT PROPN B-AC
thermogenesis NOUN O
( PUNCT O
Fig PROPN O
6E NUM O
and CCONJ O
6F NUM O
) PUNCT O
as ADP O
well ADV O
as ADP O
lower ADJ O
expression NOUN O
levels NOUN O
of ADP O
Ucp1 PROPN O
and CCONJ O
Ppargc1β NOUN O
in ADP O
BAT PROPN B-AC
( PUNCT O
S10B NOUN O
Fig PROPN O
) PUNCT O
with ADP O
no DET O
differences NOUN O
in ADP O
protein NOUN B-LF
kinase NOUN I-LF
A PROPN I-LF
( PUNCT O
PKA PROPN B-AC
) PUNCT O
phosphorylation NOUN O
( PUNCT O
S10C PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

The DET O
IFN NOUN B-LF
- NOUN I-LF
α NOUN I-LF
/ SYM I-LF
β NOUN I-LF
receptor NOUN I-LF
( PUNCT O
IFNAR1 PROPN B-AC
) PUNCT O
signals NOUN O
through ADP O
the DET O
JAK PROPN B-AC
/ SYM O
STAT PROPN B-AC
pathway NOUN O
by ADP O
phosphorylation NOUN O
of ADP O
the DET O
Janus PROPN B-LF
kinase NOUN I-LF
( PUNCT O
JAK)1 PROPN B-AC
, PUNCT O
tyrosine NOUN O
kinase NOUN O
( PUNCT O
Tyk)2 PROPN O
, PUNCT O
and CCONJ O
signal NOUN B-LF
transducer NOUN I-LF
and CCONJ I-LF
activator NOUN I-LF
of ADP I-LF
transcription NOUN I-LF
( PUNCT O
STAT)1 NOUN B-AC
and CCONJ O
STAT2 PROPN O
, PUNCT O
which PRON O
subsequently ADV O
modulates VERB O
a DET O
diverse ADJ O
array NOUN O
of ADP O
genes NOUN O
. PUNCT O

The DET O
disease NOUN O
is AUX O
characterised VERB O
by ADP O
the DET O
deposition NOUN O
in ADP O
the DET O
brain NOUN O
of ADP O
extracellular ADJ O
plaques NOUN O
of ADP O
amyloid NOUN B-LF
- PUNCT I-LF
β NOUN I-LF
( PUNCT O
Aβ NOUN B-AC
) PUNCT O
which PRON O
is AUX O
derived VERB O
from ADP O
the DET O
proteolytic ADJ O
processing NOUN O
of ADP O
APP PROPN B-AC
[ PUNCT O
5 NUM O
] PUNCT O
, PUNCT O
along ADP O
with ADP O
intracellular ADJ O
neurofibrillary ADJ O
tangles NOUN O
of ADP O
hyperphosphorylated VERB O
tau NOUN O
protein NOUN O
[ PUNCT O
6 NUM O
] PUNCT O
. PUNCT O

KO PROPN B-AC
, PUNCT O
knock NOUN B-LF
- PUNCT I-LF
out NOUN I-LF
; PUNCT O
WT PROPN O
, PUNCT O
wild NOUN O
- PUNCT O
type NOUN O
. PUNCT O

We PRON O
used VERB O
Cox PROPN O
- PUNCT O
proportional ADJ O
models NOUN O
to PART O
estimate VERB O
minimally ADV O
and CCONJ O
fully ADV O
adjusted VERB O
hazard NOUN B-LF
ratios NOUN I-LF
( PUNCT O
HRs NOUN B-AC
) PUNCT O
with ADP O
95 NUM O
% NOUN O
CIs NOUN O
for ADP O
mortality NOUN O
following VERB O
MAM PROPN B-AC
and CCONJ O
SAM PROPN B-AC
by ADP O
WLZ PROPN B-AC
, PUNCT O
MUAC PROPN B-AC
, PUNCT O
and CCONJ O
oedema NOUN O
( PUNCT O
as ADP O
relevant ADJ O
) PUNCT O
combined VERB O
and CCONJ O
then ADV O
for ADP O
individual ADJ O
indicators NOUN O
[ PUNCT O
22 NUM O
] PUNCT O
. PUNCT O

CrPAM PROPN O
, PUNCT O
C. NOUN O
reinhardtii PROPN O
peptidylglycine NOUN O
α NOUN O
- VERB O
amidating VERB O
monooxygenase NOUN O
; PUNCT O
FMG1 PROPN B-AC
, PUNCT O
flagellar ADJ B-LF
membrane NOUN I-LF
glycoprotein NOUN I-LF
1 NUM I-LF
. PUNCT O

Type NOUN B-LF
2 NUM I-LF
diabetes NOUN I-LF
mellitus NOUN I-LF
( PUNCT O
T2DM NOUN B-AC
) PUNCT O
disproportionately ADV O
affects VERB O
individuals NOUN O
of ADP O
nonwhite ADJ O
ethnic ADJ O
origin NOUN O
. PUNCT O

CFS PROPN B-AC
, PUNCT O
cross ADJ B-LF
- ADJ I-LF
frequency NOUN I-LF
PS PROPN I-LF
; PUNCT O
HF PROPN B-AC
, PUNCT O
high ADJ B-LF
frequency NOUN I-LF
; PUNCT O
LF PROPN B-AC
, PUNCT O
low ADJ B-LF
frequency NOUN I-LF
; PUNCT O
MEG PROPN B-AC
, PUNCT O
magnetoencephalography NOUN B-LF
; PUNCT O
PAC PROPN B-AC
, PUNCT O
phase NOUN B-LF
– PUNCT I-LF
amplitude NOUN I-LF
coupling NOUN I-LF
; PUNCT O
PS PROPN B-AC
, PUNCT O
phase NOUN B-LF
synchrony NOUN I-LF
; PUNCT O
SEEG PROPN B-AC
, PUNCT O
stereoelectroencephalography NOUN B-LF
. PUNCT O

NSHD PROPN B-AC
: PUNCT O
Medical PROPN O
Research PROPN O
Council PROPN O
National PROPN B-LF
Survey PROPN I-LF
of ADP I-LF
Health PROPN I-LF
and CCONJ I-LF
Development PROPN I-LF
, PUNCT O
NCDS PROPN B-AC
National PROPN B-LF
Child PROPN I-LF
Development PROPN I-LF
Study PROPN I-LF
, PUNCT O
BCS PROPN B-AC
: PUNCT O
British PROPN B-LF
Cohort PROPN I-LF
Study PROPN I-LF
, PUNCT O
ALSPAC PROPN B-AC
: PUNCT O
Avon PROPN B-LF
Longitudinal PROPN I-LF
Study PROPN I-LF
of ADP I-LF
Parents PROPN I-LF
and CCONJ I-LF
Children PROPN I-LF
, PUNCT O
MCS PROPN B-AC
: PUNCT O
Millennium PROPN B-LF
Cohort PROPN I-LF
Study PROPN I-LF
. PUNCT O

Approaches NOUN O
using VERB O
HPV PROPN B-AC
DNA NOUN O
tests NOUN O
can AUX O
be AUX O
easily ADV O
adapted VERB O
to ADP O
resource NOUN O
- PUNCT O
limited VERB O
settings NOUN O
, PUNCT O
allow VERB O
for ADP O
self NOUN O
- PUNCT O
collected VERB O
samples NOUN O
, PUNCT O
and CCONJ O
are AUX O
less ADV O
observer NOUN O
dependent ADJ O
than ADP O
visual ADJ O
inspection NOUN O
methods NOUN O
, PUNCT O
which PRON O
have VERB O
variable ADJ O
sensitivity NOUN O
and CCONJ O
specificity NOUN O
among ADP O
women NOUN B-LF
living VERB I-LF
with ADP I-LF
HIV PROPN I-LF
( PUNCT O
WLHIV PROPN B-AC
) PUNCT O
[ PUNCT O
4–6 NUM O
] PUNCT O
. PUNCT O

Low ADJ O
heart NOUN B-LF
rate NOUN I-LF
variability NOUN I-LF
( PUNCT O
HRV NOUN B-AC
) PUNCT O
has AUX O
been AUX O
linked VERB O
to ADP O
increased VERB O
total ADJ O
mortality NOUN O
in ADP O
the DET O
general ADJ O
population NOUN O
; PUNCT O
however ADV O
, PUNCT O
the DET O
relationship NOUN O
between ADP O
low ADJ O
HRV NOUN B-AC
and CCONJ O
sudden ADJ B-LF
cardiac ADJ I-LF
death NOUN I-LF
( PUNCT O
SCD NOUN B-AC
) PUNCT O
is AUX O
less ADV O
well ADV O
- PUNCT O
characterized VERB O
. PUNCT O

We PRON O
aimed VERB O
to PART O
identify VERB O
the DET O
risk NOUN O
factors NOUN O
associated VERB O
with ADP O
colonic ADJ O
cytomegalovirus NOUN B-LF
( PUNCT O
CMV NOUN B-AC
) PUNCT O
infection NOUN O
in ADP O
ulcerative ADJ B-LF
colitis NOUN I-LF
( PUNCT O
UC PROPN B-AC
) PUNCT O
and CCONJ O
to PART O
compare VERB O
the DET O
clinical ADJ O
course NOUN O
between ADP O
antiviral ADJ O
therapy NOUN O
- NOUN O
treated VERB O
and CCONJ O
-untreated ADJ O
groups NOUN O
in ADP O
mucosal ADJ O
CMV NOUN B-AC
- NOUN O
polymerase NOUN B-LF
chain NOUN I-LF
reaction NOUN I-LF
( PUNCT O
PCR PROPN B-AC
) PUNCT O
-positive ADJ O
cases NOUN O
. PUNCT O

The DET O
Model PROPN B-LF
for ADP I-LF
End PROPN I-LF
Stage PROPN I-LF
Liver PROPN I-LF
Disease PROPN I-LF
( PUNCT O
MELD PROPN B-AC
) PUNCT O
has AUX O
been AUX O
used VERB O
as ADP O
the DET O
method NOUN O
of ADP O
liver NOUN O
graft NOUN O
allocation NOUN O
since SCONJ O
2002 NUM O
. PUNCT O

Crohn PROPN B-LF
’s PART I-LF
disease NOUN I-LF
[ X O
CD NOUN B-AC
] PUNCT O
and CCONJ O
ulcerative ADJ B-LF
colitis NOUN I-LF
[ X O
UC])[1 X B-AC
] PUNCT O
. PUNCT O

All DET O
biological ADJ O
processes NOUN O
in ADP O
apicomplexan ADJ O
parasites NOUN O
known VERB O
to PART O
require VERB O
PKG PROPN B-AC
are AUX O
also ADV O
thought VERB O
to PART O
rely VERB O
on ADP O
the DET O
release NOUN O
of ADP O
Ca2 NOUN O
+ NOUN O
from ADP O
intracellular ADJ O
stores NOUN O
[ PUNCT O
11],[31],[32],[35],[36 NUM O
] PUNCT O
, PUNCT O
which PRON O
in ADP O
turn NOUN O
activates VERB O
distinct ADJ O
stage NOUN O
- PUNCT O
specific ADJ O
effector NOUN O
pathways NOUN O
including VERB O
members NOUN O
of ADP O
a DET O
family NOUN O
of ADP O
plant NOUN O
- PUNCT O
like ADJ O
Ca2 NOUN B-LF
+ NOUN I-LF
-dependent ADJ I-LF
protein NOUN I-LF
kinases NOUN I-LF
( PUNCT O
CDPKs PROPN B-AC
) PUNCT O
[ PUNCT O
37 NUM O
] PUNCT O
. PUNCT O

To PART O
first ADV O
assay VERB O
this PRON O
, PUNCT O
TrkC PROPN B-AC
- PUNCT B-AC
KF PROPN B-AC
was AUX O
fused VERB O
to PART O
a DET O
Gal4 PROPN O
DNA NOUN B-LF
- PUNCT I-LF
binding VERB I-LF
domain NOUN I-LF
( PUNCT O
DBD PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
SHEP PROPN O
cells NOUN O
were AUX O
forced VERB O
to PART O
express VERB O
TrkC PROPN B-AC
- PUNCT B-AC
KF PROPN B-AC
- PUNCT O
Gal4DBD PROPN O
together ADV O
with ADP O
a DET O
construct NOUN O
encoding VERB O
a DET O
luciferase NOUN O
reporter NOUN O
gene NOUN O
under ADP O
the DET O
control NOUN O
of ADP O
the DET O
upstream ADJ B-LF
activating VERB I-LF
sequence NOUN I-LF
( PUNCT O
UAS)-GAL4 PROPN B-AC
promoter NOUN O
. PUNCT O

We PRON O
conducted VERB O
a DET O
retrospective ADJ O
chart NOUN O
review NOUN O
of ADP O
all DET O
male ADJ O
patients NOUN O
seen VERB O
in ADP O
the DET O
Pediatric PROPN O
Endocrinology PROPN O
Division PROPN O
at ADP O
Boston PROPN B-LF
Children PROPN I-LF
’s PART I-LF
Hospital PROPN I-LF
( PUNCT O
BCH PROPN B-AC
) PUNCT O
between ADP O
2001–2010 NUM O
with ADP O
an DET O
International PROPN B-LF
Statistical PROPN I-LF
Classification PROPN I-LF
of ADP I-LF
Diseases PROPN I-LF
9th ADJ I-LF
edition NOUN I-LF
( PUNCT O
ICD-9 NOUN B-AC
) PUNCT O
code NOUN O
for ADP O
PP PROPN B-AC
( PUNCT O
ICD-9 NOUN B-AC
259.1 NUM O
) PUNCT O
. PUNCT O

In ADP O
2013 NUM O
, PUNCT O
the DET O
benchmark NOUN O
CANONIC PROPN B-AC
Study PROPN O
by ADP O
the DET B-LF
European PROPN I-LF
Association PROPN I-LF
for ADP I-LF
the DET I-LF
Study PROPN I-LF
of ADP I-LF
the DET I-LF
Liver PROPN I-LF
- PUNCT O
Chronic PROPN B-LF
Liver PROPN I-LF
Failure PROPN I-LF
Consortium PROPN I-LF
( PUNCT O
EASL PROPN B-AC
CLIF PROPN B-AC
- PUNCT B-AC
C PROPN B-AC
) PUNCT O
introduced VERB O
the DET O
concept NOUN O
of ADP O
analyzing VERB O
each DET O
“ PUNCT O
acute ADJ B-LF
decompensation NOUN I-LF
( PUNCT O
AD NOUN B-AC
) PUNCT O
” PUNCT O
of ADP O
cirrhosis NOUN O
, PUNCT O
characterized VERB O
end NOUN O
- PUNCT O
organ NOUN O
insufficiency NOUN O
in ADP O
six NUM O
organ NOUN O
systems NOUN O
, PUNCT O
and CCONJ O
practically ADV O
and CCONJ O
clearly ADV O
defined VERB O
the DET O
clinical ADJ O
state NOUN O
of ADP O
“ PUNCT O
acute ADJ B-LF
- PUNCT I-LF
on ADP I-LF
- PUNCT I-LF
chronic ADJ I-LF
liver NOUN I-LF
failure NOUN I-LF
( PUNCT O
ACLF PROPN B-AC
) PUNCT O
” PUNCT O
[ PUNCT O
3 NUM O
] PUNCT O
. PUNCT O

AA PROPN O
, PUNCT O
CRY171A/280A PROPN O
; PUNCT O
CRY1 PROPN O
, PUNCT O
CRYPTOCHROME PROPN O
1 NUM O
; PUNCT O
JMJD5 PROPN B-AC
, PUNCT O
JmjC PROPN B-LF
domain NOUN I-LF
– PUNCT I-LF
containing VERB I-LF
protein NOUN I-LF
5 NUM I-LF
. PUNCT O

In ADP O
order NOUN O
to ADP O
confirm VERB O
that SCONJ O
MITF PROPN O
binds VERB O
to ADP O
these DET O
loci NOUN O
in ADP O
mouse NOUN O
melanocytes NOUN O
, PUNCT O
we PRON O
assessed VERB O
MITF PROPN O
occupancy NOUN O
using VERB O
chromatin NOUN B-LF
immunoprecipitation NOUN I-LF
quantitative ADJ I-LF
polymerase NOUN I-LF
chain NOUN I-LF
reaction NOUN I-LF
( PUNCT O
ChIP PROPN B-AC
- PUNCT B-AC
qPCR PROPN B-AC
) PUNCT O
for ADP O
three NUM O
of ADP O
the DET O
seven NUM O
ISGs NOUN B-AC
in ADP O
melan NOUN O
- PUNCT O
a NOUN O
cells NOUN O
. PUNCT O

FDR PROPN O
, PUNCT O
false ADJ O
discovery NOUN O
rate NOUN O
; PUNCT O
iEEG PROPN B-AC
, PUNCT O
intracranial ADJ O
electroencephalography NOUN O
; PUNCT O
ROI NOUN B-AC
, PUNCT O
region NOUN B-LF
of ADP I-LF
interest NOUN I-LF
; PUNCT O
SME NOUN B-AC
, PUNCT O
subsequent ADJ B-LF
memory NOUN I-LF
effect NOUN I-LF
. PUNCT O

Hormone NOUN O
biosynthetic ADJ O
mutants NOUN O
that PRON O
reduce VERB O
production NOUN O
of ADP O
the DET O
dafachronic ADJ B-LF
acids NOUN I-LF
( PUNCT O
DAs PROPN B-AC
) PUNCT O
have VERB O
a DET O
characteristic ADJ O
phenotypic ADJ O
profile NOUN O
. PUNCT O

LV NOUN O
/ SYM O
RVES NOUN O
/ SYM O
DVI- NOUN O
left ADJ O
/ SYM O
right ADJ O
ventricular ADJ O
end NOUN O
- PUNCT O
systolic ADJ O
/ SYM O
diastolic ADJ O
volume NOUN O
indexed VERB O
, PUNCT O
LV NOUN O
/ SYM O
RVEF- NOUN B-AC
left ADJ O
/ SYM O
right ADJ B-LF
ventricular ADJ I-LF
ejection NOUN I-LF
fraction NOUN I-LF
, PUNCT O
RVOTD NOUN O
/ SYM O
VI- NOUN O
right ADJ O
ventricular ADJ O
outflow NOUN O
tract NOUN O
diameter NOUN O
/ SYM O
volume NOUN O
indexed VERB O
. PUNCT O

The DET O
4 NUM O
blue ADJ O
arrows NOUN O
indicate VERB O
4 NUM O
of ADP O
the DET O
above ADJ O
8 NUM O
patients NOUN O
who PRON O
were AUX O
ctDNA PROPN B-AC
non NOUN O
- ADJ O
clearance NOUN O
, PUNCT O
and CCONJ O
the DET O
4 NUM O
yellow ADJ O
arrows NOUN O
indicate VERB O
the DET O
other ADJ O
4 NUM O
patients NOUN O
who PRON O
were AUX O
ctDNA PROPN B-AC
clearance NOUN O
. PUNCT O
( PUNCT O
B X O
) PUNCT O
The DET O
distribution NOUN O
of ADP O
patients NOUN O
with ADP O
acquired VERB O
mutations NOUN O
in ADP O
different ADJ O
clinicopathological ADJ O
groups NOUN O
( PUNCT O
n NOUN O
= SYM O
103 NUM O
) PUNCT O
. PUNCT O
cCR PROPN B-AC
, PUNCT O
clinical ADJ B-LF
complete ADJ I-LF
response NOUN I-LF
; PUNCT O
ctDNA PROPN B-AC
, PUNCT O
circulating VERB B-LF
tumor NOUN I-LF
DNA NOUN I-LF
; PUNCT O
MRI PROPN B-AC
, PUNCT O
magnetic ADJ B-LF
resonance NOUN I-LF
imaging NOUN I-LF
; PUNCT O
mrTRG PROPN B-AC
, PUNCT O
magnetic ADJ B-LF
resonance NOUN I-LF
imaging NOUN I-LF
tumor NOUN I-LF
regression NOUN I-LF
grade NOUN I-LF
; PUNCT O
nCRT PROPN B-AC
, PUNCT O
neoadjuvant ADJ B-LF
chemoradiotherapy NOUN I-LF
; PUNCT O
pCR NOUN B-AC
, PUNCT O
pathological ADJ B-LF
complete ADJ I-LF
response NOUN I-LF
; PUNCT O
pTRG PROPN B-AC
, PUNCT O
pathological ADJ B-LF
tumor NOUN I-LF
regression NOUN I-LF
grade NOUN I-LF
; PUNCT O
VAF PROPN B-AC
, PUNCT O
variant NOUN B-LF
allele NOUN I-LF
frequency NOUN I-LF
. PUNCT O

No DET O
volunteer NOUN O
had VERB O
a DET O
positive ADJ O
HIV PROPN O
enzyme NOUN B-LF
immunoassay NOUN I-LF
( PUNCT O
EIA PROPN B-AC
) PUNCT O
response NOUN O
during ADP O
the DET O
study NOUN O
. PUNCT O

MCI PROPN B-AC
, PUNCT O
mild ADJ B-LF
cognitive ADJ I-LF
impairment NOUN I-LF

We PRON O
stimulated VERB O
freshly ADV O
isolated VERB O
fetal ADJ O
liver NOUN O
cells NOUN O
with ADP O
Epo PROPN B-AC
and CCONJ O
examined VERB O
the DET O
resulting VERB O
p NOUN B-AC
- PUNCT B-AC
Stat5 NOUN B-AC
response NOUN O
in ADP O
each PRON O
of ADP O
the DET O
fetal ADJ O
liver NOUN O
subsets NOUN O
( PUNCT O
Figure NOUN O
S1A NOUN O
; PUNCT O
Figure NOUN O
1C NUM O
– SYM O
E NOUN O
) PUNCT O
. PUNCT O
We PRON O
measured VERB O
three NUM O
aspects NOUN O
of ADP O
the DET O
p NOUN B-AC
- PUNCT B-AC
Stat5 NOUN B-AC
fluorescence NOUN O
signal NOUN O
( PUNCT O
Figure NOUN O
1C NUM O
) PUNCT O
. PUNCT O
First ADV O
, PUNCT O
“ PUNCT O
total ADJ O
p NOUN B-AC
- PUNCT B-AC
Stat5 NOUN B-AC
” PUNCT O
corresponds VERB O
to ADP O
the DET O
p NOUN B-AC
- PUNCT B-AC
Stat5 NOUN B-AC
median ADJ B-LF
fluorescence NOUN I-LF
intensity NOUN I-LF
( PUNCT O
MFI PROPN B-AC
) PUNCT O
of ADP O
the DET O
entire ADJ O
subset NOUN O
population NOUN O
; PUNCT O
the DET O
total ADJ O
p NOUN B-AC
- PUNCT B-AC
Stat5 NOUN B-AC
MFI PROPN B-AC
of ADP O
all DET O
S3 PROPN O
subset NOUN O
cells NOUN O
in ADP O
the DET O
red ADJ O
histogram NOUN O
, PUNCT O
upper ADJ O
panel NOUN O
of ADP O
Figure NOUN O
1C NUM O
, PUNCT O
is AUX O
1,200 NUM O
fluorescence NOUN O
units NOUN O
. PUNCT O

BMDC PROPN B-AC
( PUNCT O
Kb PROPN O
haplotype NOUN O
) PUNCT O
were AUX O
cultured VERB O
from ADP O
WT PROPN O
and CCONJ O
TLR2−/− NOUN O
bone NOUN O
marrow NOUN O
for ADP O
7 NUM O
d NOUN O
as SCONJ O
described VERB O
previously ADV O
, PUNCT O
then ADV O
activated VERB O
by ADP O
incubating VERB O
with ADP O
100 NUM O
μg NOUN O
/ ADP O
ml NOUN O
GL26 NOUN O
cell NOUN O
extract NOUN O
for ADP O
24 NUM O
h NOUN O
( PUNCT O
at ADP O
37 NUM O
° NOUN O
C NOUN O
) PUNCT O
. PUNCT O
CD4 PROPN O
and CCONJ O
CD8 PROPN O
T NOUN O
cells NOUN O
were AUX O
isolated VERB O
using VERB O
a DET O
magnetic ADJ B-LF
activated VERB I-LF
cell NOUN I-LF
sorter NOUN I-LF
( PUNCT O
MACS PROPN B-AC
) PUNCT O
from ADP O
total ADJ O
splenocytes NOUN O
of ADP O
Balb(c NOUN O
) PUNCT O
mice NOUN O
( PUNCT O
Kd PROPN O
haplotype NOUN O
) PUNCT O
using VERB O
mouse NOUN O
CD4 PROPN O
( PUNCT O
L3T4 PROPN O
) PUNCT O
and CCONJ O
CD8a NOUN O
( PUNCT O
Ly-2 PROPN O
) PUNCT O
magnetic ADJ O
beads NOUN O
( PUNCT O
Miltenyi PROPN O
Biotec PROPN O
) PUNCT O
. PUNCT O

The DET O
current ADJ O
biomarkers NOUN O
for ADP O
diagnosis NOUN O
of ADP O
sepsis NOUN O
or CCONJ O
infections NOUN O
include VERB O
white ADJ B-LF
blood NOUN I-LF
cell NOUN I-LF
( PUNCT O
WBC PROPN B-AC
) PUNCT O
count NOUN O
, PUNCT O
lactic ADJ O
acid NOUN O
, PUNCT O
procalcitonin NOUN O
, PUNCT O
and CCONJ O
C NOUN B-LF
- NOUN I-LF
reactive ADJ I-LF
protein NOUN I-LF
( PUNCT O
CRP PROPN B-AC
) PUNCT O
[ PUNCT O
1–3 NUM O
] PUNCT O
. PUNCT O

The DET B-AC
majority NOUN O
of ADP O
known VERB O
virulence NOUN O
factors NOUN O
, PUNCT O
including VERB O
adhesins NOUN O
( PUNCT O
filamentous ADJ B-LF
hemagglutinin NOUN I-LF
[ PUNCT O
FHA PROPN B-AC
] PUNCT O
, PUNCT O
pertactin NOUN O
, PUNCT O
and CCONJ O
fimbriae NOUN O
) PUNCT O
and CCONJ O
toxins NOUN O
( PUNCT O
adenylate NOUN B-LF
cyclase NOUN I-LF
toxin NOUN I-LF
[ PUNCT O
ACT PROPN B-AC
] PUNCT O
and CCONJ O
dermonecrotic ADJ O
toxin NOUN O
) PUNCT O
are AUX O
expressed VERB O
by ADP O
both DET O
B. PROPN O
bronchiseptica NOUN O
and CCONJ O
B. PROPN O
pertussis NOUN O
. PUNCT O

Hazard NOUN B-LF
quotient NOUN I-LF
( PUNCT O
HQ NOUN B-AC
) PUNCT O
was AUX O
used VERB O
for ADP O
long ADJ O
- PUNCT O
term NOUN O
risk NOUN O
assessment NOUN O
. PUNCT O
HQ NOUN B-AC
( PUNCT O
% NOUN O
) PUNCT O
= SYM O
EDI NOUN B-AC
/ SYM O
ADI PROPN B-AC
× SYM O
100(7 NUM O
) PUNCT O
where SCONJ O
ADI PROPN B-AC
was AUX O
the DET O
acceptable ADJ B-LF
daily ADJ I-LF
intake NOUN I-LF
of ADP O
a DET O
pesticide NOUN O
. PUNCT O

This DET O
study NOUN O
was AUX O
prospectively ADV O
registered VERB O
in ADP O
International PROPN B-LF
Prospective PROPN I-LF
Register PROPN I-LF
of ADP I-LF
Systematic PROPN I-LF
Reviews PROPN I-LF
( PUNCT O
PROSPERO PROPN B-AC
; PUNCT O
CRD42017069087 NUM O
) PUNCT O
. PUNCT O

Patient PROPN B-LF
Reported PROPN I-LF
Outcomes NOUN I-LF
( PUNCT O
PRO PROPN B-AC
) PUNCT O
are AUX O
established VERB O
outcome NOUN O
parameters NOUN O
[ X O
54 NUM O
] PUNCT O
. PUNCT O

However ADV O
, PUNCT O
majority NOUN O
( PUNCT O
88 NUM O
% NOUN O
) PUNCT O
of ADP O
the DET O
HCC PROPN B-AC
samples NOUN O
used VERB O
in ADP O
their PRON O
study NOUN O
have VERB O
hepatitis NOUN B-LF
B NOUN I-LF
virus NOUN I-LF
( PUNCT O
HBV PROPN B-AC
) PUNCT O
infection NOUN O
and CCONJ O
the DET O
association NOUN O
between ADP O
Cu PROPN B-AC
/ SYM O
Zn PROPN B-AC
and CCONJ O
survival NOUN O
was AUX O
prominent ADJ O
only ADV O
among ADP O
hepatitis NOUN O
B NOUN O
negative ADJ O
patients NOUN O
. PUNCT O

Both DET O
studies NOUN O
were AUX O
approved VERB O
by ADP O
the DET O
Institutional PROPN O
Review PROPN O
Board PROPN O
Committee PROPN O
of ADP O
the DET O
Taiwan PROPN B-LF
Centers PROPN I-LF
for ADP I-LF
Disease PROPN I-LF
Control PROPN I-LF
( PUNCT O
CDC PROPN B-AC
) PUNCT O
. PUNCT O

Failure NOUN O
is AUX O
given VERB O
after ADP O
1 NUM O
and CCONJ O
2 NUM O
years NOUN O
of ADP O
ART PROPN B-AC
. PUNCT O
ART PROPN B-AC
, PUNCT O
antiretroviral ADJ B-LF
therapy NOUN I-LF
; PUNCT O
DTG PROPN B-AC
, PUNCT O
dolutegravir NOUN B-LF
; PUNCT O
NNRTI PROPN B-AC
, PUNCT O
non ADJ B-LF
- ADJ I-LF
nucleoside ADJ I-LF
reverse ADJ I-LF
transcriptase NOUN I-LF
inhibitor NOUN I-LF
. PUNCT O

ASC PROPN B-AC
, PUNCT O
apoptosis NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
speck NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
protein NOUN I-LF
; PUNCT O
BMDM PROPN B-AC
, PUNCT O
bone NOUN B-LF
marrow NOUN I-LF
– PUNCT I-LF
derived VERB I-LF
macrophage NOUN I-LF
; PUNCT O
CRISPR NOUN B-AC
- PUNCT B-AC
Cas9 PROPN B-AC
, PUNCT O
clustered VERB B-LF
regularly ADV I-LF
interspersed VERB I-LF
short ADJ I-LF
palindromic ADJ I-LF
repeats NOUN I-LF
– PUNCT I-LF
CRISPR NOUN I-LF
- PUNCT I-LF
associated VERB I-LF
protein NOUN I-LF
9 NUM I-LF
; PUNCT O
gRNA NOUN O
, PUNCT O
guide NOUN O
RNA NOUN O
; PUNCT O
PAM PROPN O
, PUNCT O
protospacer NOUN O
adjacent ADJ O
motif NOUN O
; PUNCT O
PCR PROPN O
, PUNCT O
polymerase NOUN O
chain NOUN O
reaction NOUN O
. PUNCT O

As SCONJ O
reported VERB O
by ADP O
Mendelian ADJ O
randomization NOUN O
studies NOUN O
, PUNCT O
a DET O
lifetime NOUN O
reduction NOUN O
of ADP O
low ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
cholesterol NOUN I-LF
( PUNCT O
LDL NOUN B-AC
- PUNCT B-AC
C NOUN B-AC
) PUNCT O
of ADP O
1 NUM O
mmol NOUN O
/ SYM O
l NOUN O
might AUX O
reduce VERB O
the DET O
potential ADJ O
risk NOUN O
of ADP O
atherosclerotic ADJ O
CVDs NOUN B-AC
by ADP O
over ADP O
50 NUM O
% NOUN O
[ PUNCT O
2 NUM O
] PUNCT O
. PUNCT O

We PRON O
used VERB O
the DET O
area NOUN B-LF
under ADP I-LF
the DET I-LF
curve NOUN I-LF
( PUNCT O
AUC PROPN B-AC
) PUNCT O
of ADP O
a DET O
receiver NOUN B-LF
operator NOUN I-LF
characteristics NOUN I-LF
( PUNCT O
ROC PROPN B-AC
) PUNCT O
graph NOUN O
to PART O
assess VERB O
the DET O
accuracy NOUN O
of ADP O
the DET O
PwD PROPN B-AC
, PUNCT O
BED PROPN B-AC
and CCONJ O
Lag PROPN O
assays NOUN O
to PART O
identify VERB O
HIV PROPN O
infection NOUN O
recency NOUN O
. PUNCT O

This DET O
study NOUN O
used VERB O
the DET O
Life PROPN B-LF
Support PROPN I-LF
Preferences PROPN I-LF
Questionnaire PROPN I-LF
( PUNCT O
LSPQ PROPN B-AC
) PUNCT O
to PART O
explore VERB O
whether SCONJ O
family NOUN O
carers NOUN O
’ PART O
choices NOUN O
show VERB O
agreement NOUN O
with ADP O
the DET O
end NOUN O
of ADP O
life NOUN O
care VERB O
preferences NOUN O
of ADP O
the DET O
person NOUN O
with ADP O
dementia NOUN O
for ADP O
whom PRON O
they PRON O
care VERB O
and CCONJ O
what DET O
factors NOUN O
influence VERB O
this PRON O
. PUNCT O

Up ADP O
to ADP O
5 NUM O
% NOUN O
Gross PROPN B-LF
Domestic PROPN I-LF
Product PROPN I-LF
( PUNCT O
GDP PROPN B-AC
) PUNCT O
economic ADJ O
loss NOUN O
is AUX O
attributed VERB O
to ADP O
Road NOUN O
traffic NOUN O
deaths NOUN O
and CCONJ O
injuries NOUN O
in ADP O
low ADJ O
and CCONJ O
middle NOUN O
- PUNCT O
income NOUN O
countries NOUN O
[ PUNCT O
9 NUM O
, PUNCT O
10 NUM O
] PUNCT O
. PUNCT O

Arp2/3 NOUN B-AC
, PUNCT O
actin NOUN B-LF
- PUNCT I-LF
related VERB I-LF
protein NOUN I-LF
2/3 NUM I-LF
; PUNCT O
WASp PROPN B-AC
, PUNCT O
Wiskott PROPN B-LF
– PUNCT I-LF
Aldrich PROPN I-LF
syndrome PROPN I-LF
protein NOUN I-LF
. PUNCT O

To PART O
examine VERB O
this PRON O
, PUNCT O
we PRON O
performed VERB O
glutathione NOUN B-LF
s NOUN I-LF
- NOUN I-LF
transferase NOUN I-LF
( PUNCT O
GST PROPN B-AC
) PUNCT O
pull VERB O
- NOUN O
down ADP O
experiments NOUN O
followed VERB O
by ADP O
western ADJ O
blot NOUN O
confirmation NOUN O
using VERB O
recombinant ADJ O
CsgF PROPN O
variant NOUN O
proteins NOUN O
that PRON O
are AUX O
fused VERB O
to ADP O
GST PROPN B-AC
C PROPN O
- NOUN O
terminally ADV O
. PUNCT O

While SCONJ O
analysing VERB O
the DET O
proportion NOUN O
of ADP O
axons NOUN O
that SCONJ O
are AUX O
myelinated VERB O
at ADP O
P40 NUM O
, PUNCT O
we PRON O
observed VERB O
, PUNCT O
paradoxically ADV O
, PUNCT O
that SCONJ O
despite SCONJ O
the DET O
reduced VERB O
initiation NOUN O
in ADP O
smaller ADJ O
diameter NOUN O
axons NOUN O
, PUNCT O
fully ADV O
compacted VERB O
myelin NOUN O
sheaths NOUN O
that SCONJ O
were AUX O
formed VERB O
in ADP O
Scribble PROPN O
cKO PROPN B-AC
optic ADJ O
nerve NOUN O
and CCONJ O
spinal ADJ O
cord NOUN O
( PUNCT O
Fig PROPN O
. PUNCT O
7B NUM O
, PUNCT O
E NOUN O
) PUNCT O
appeared VERB O
thicker ADJ O
than ADP O
those PRON O
in ADP O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
animals NOUN O
( PUNCT O
Fig PROPN O
. PUNCT O
7A NUM O
, PUNCT O
D NOUN O
) PUNCT O
. PUNCT O
Quantification NOUN O
of ADP O
the DET O
g NOUN O
- PUNCT O
ratio NOUN O
( PUNCT O
the DET O
ratio NOUN O
of ADP O
axon NOUN O
circumference NOUN O
to ADP O
myelin NOUN O
circumference NOUN O
) PUNCT O
confirmed VERB O
this DET O
, PUNCT O
being AUX O
decreased VERB O
in ADP O
Scribble PROPN O
cKO PROPN B-AC
optic ADJ O
nerve NOUN O
and CCONJ O
spinal ADJ O
cord NOUN O
relative ADJ O
to ADP O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
fibres NOUN O
( PUNCT O
Fig PROPN O
. PUNCT O
7 NUM O
G NOUN O
) PUNCT O
. PUNCT O
When SCONJ O
this DET O
ratio NOUN O
was AUX O
plotted VERB O
against ADP O
axon NOUN O
diameter NOUN O
, PUNCT O
lower ADJ O
values NOUN O
were AUX O
seen VERB O
for ADP O
all DET O
axon NOUN O
diameters NOUN O
and CCONJ O
the DET O
equations NOUN O
for ADP O
the DET O
best ADJ O
- PUNCT O
fit NOUN O
lines NOUN O
for ADP O
WT PROPN B-AC
and CCONJ O
cKO PROPN B-AC
datasets NOUN O
obtained VERB O
by ADP O
linear ADJ O
regression NOUN O
differed VERB O
significantly ADV O
in ADP O
both CCONJ O
optic ADJ O
nerve NOUN O
( PUNCT O
Fig PROPN O
. PUNCT O
7H NUM O
) PUNCT O
and CCONJ O
spinal ADJ O
cord NOUN O
( PUNCT O
Fig PROPN O
. PUNCT O
7I NUM O
) PUNCT O
. PUNCT O
The DET O
periodicity NOUN O
of ADP O
myelin NOUN O
lamellae NOUN O
was AUX O
unchanged ADJ O
in ADP O
both CCONJ O
optic ADJ O
nerve NOUN O
and CCONJ O
spinal ADJ O
cord NOUN O
( PUNCT O
S2 PROPN O
Fig PROPN O
) PUNCT O
, PUNCT O
indicating VERB O
that SCONJ O
the DET O
decreased VERB O
g NOUN O
- PUNCT O
ratios NOUN O
were AUX O
due ADJ O
to ADP O
the DET O
presence NOUN O
of ADP O
more ADJ O
myelin NOUN O
wraps NOUN O
, PUNCT O
not PART O
increased VERB O
spacing NOUN O
between ADP O
them PRON O
. PUNCT O

Mechanistically ADV O
, PUNCT O
the DET O
N NOUN O
- NOUN O
terminus NOUN O
of ADP O
CEP290 PROPN B-AC
directly ADV O
recruits VERB O
DAZ NOUN B-LF
interacting VERB I-LF
zinc NOUN I-LF
finger NOUN I-LF
protein NOUN I-LF
1 NUM I-LF
( PUNCT O
DZIP1 PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
then ADV O
recruits VERB O
Chibby PROPN B-LF
( PUNCT O
CBY PROPN B-AC
) PUNCT O
and CCONJ O
Rab8 PROPN O
to PART O
promote VERB O
early ADJ O
ciliary ADJ O
membrane NOUN O
formation NOUN O
. PUNCT O

This PRON O
is AUX O
consistent ADJ O
with ADP O
MHC PROPN B-AC
class NOUN O
I NUM O
evolving VERB O
faster ADV O
than ADP O
class NOUN O
II NUM O
because SCONJ O
of ADP O
pressure NOUN O
from ADP O
rapidly ADV O
evolving VERB O
intracellular ADJ O
pathogens NOUN O
such ADJ O
as ADP O
RNA NOUN O
viruses NOUN O
, PUNCT O
like ADP O
the DET O
human ADJ B-LF
immunodeficiency NOUN I-LF
viruses NOUN I-LF
( PUNCT O
HIV PROPN B-AC
) PUNCT O
. PUNCT O
In ADP O
fact NOUN O
, PUNCT O
the DET O
great ADJ O
apes NOUN O
( PUNCT O
chimpanzee NOUN O
, PUNCT O
bonobo NOUN O
, PUNCT O
gorilla NOUN O
, PUNCT O
and CCONJ O
orangutan NOUN O
) PUNCT O
are AUX O
the DET O
only ADJ O
living VERB O
species NOUN O
that PRON O
have VERB O
orthologs NOUN O
of ADP O
all DET O
three NUM O
polymorphic ADJ O
human ADJ O
MHC PROPN B-AC
class NOUN O
I NUM O
molecules NOUN O
, PUNCT O
HLA PROPN O
- PUNCT O
A PROPN O
, PUNCT O
-B PROPN O
, PUNCT O
and CCONJ O
-C PROPN O
[ PUNCT O
8 NUM O
] PUNCT O
. PUNCT O

Furthermore ADV O
, PUNCT O
Dermitzakis PROPN O
et PROPN O
al NOUN O
. PUNCT O
showed VERB O
that PRON O
conserved ADJ B-LF
nongenic ADJ I-LF
sequences NOUN I-LF
( PUNCT O
CNGs PROPN B-AC
) PUNCT O
, PUNCT O
ungapped ADJ O
100 NUM O
- PUNCT O
bp NOUN O
fragments NOUN O
with ADP O
at ADV O
least ADV O
70 NUM O
% NOUN O
identity NOUN O
between ADP O
human NOUN O
and CCONJ O
mouse NOUN O
that PRON O
are AUX O
presumed VERB O
factor NOUN O
- PUNCT O
binding VERB O
regions NOUN O
, PUNCT O
have VERB O
no DET O
significant ADJ O
preference NOUN O
for ADP O
promoter NOUN O
proximal ADJ O
regions NOUN O
[ X O
27,28 NUM O
] PUNCT O
. PUNCT O

The DET B-LF
ratio NOUN I-LF
of ADP I-LF
residual ADJ I-LF
volume NOUN I-LF
to ADP I-LF
total ADJ I-LF
lung NOUN I-LF
capacity NOUN I-LF
( PUNCT O
RV NOUN B-AC
/ SYM B-AC
TLC NOUN B-AC
) PUNCT O
is AUX O
a DET O
more ADV O
comprehensive ADJ O
parameter NOUN O
that PRON O
could AUX O
be AUX O
readily ADV O
calculated VERB O
based VERB O
on ADP O
the DET O
functional ADJ O
residual ADJ O
capacity NOUN O
. PUNCT O

We PRON O
estimated VERB O
the DET O
association NOUN O
of ADP O
AO PROPN B-AC
and CCONJ O
cardiovascular ADJ B-LF
risk NOUN I-LF
factors NOUN I-LF
( PUNCT O
CVRF PROPN B-AC
) PUNCT O
and CCONJ O
disease NOUN O
in ADP O
non ADJ O
- ADJ O
obese ADJ O
adult ADJ O
individuals NOUN O
from ADP O
Chile PROPN O
. PUNCT O

PSD PROPN B-AC
, PUNCT O
power NOUN B-LF
spectrum NOUN I-LF
density NOUN I-LF
; PUNCT O
ANOVA NOUN B-AC
, PUNCT O
analysis NOUN B-LF
of ADP I-LF
variance NOUN I-LF
; PUNCT O
SD NOUN B-AC
, PUNCT O
standard ADJ B-LF
deviations NOUN I-LF
. PUNCT O

OUD PROPN B-AC
, PUNCT O
opioid NOUN B-LF
use NOUN I-LF
disorder NOUN I-LF
. PUNCT O

Since SCONJ O
their PRON O
introduction NOUN O
in ADP O
2009 NUM O
, PUNCT O
the DET O
proportion NOUN O
of ADP O
direct ADJ B-LF
oral ADJ I-LF
anticoagulants NOUN I-LF
( PUNCT O
DOAC PROPN B-AC
) PUNCT O
is AUX O
increasing VERB O
constantly ADV O
[ PUNCT O
5 NUM O
] PUNCT O
. PUNCT O

It PRON O
has AUX O
been AUX O
reported VERB O
that SCONJ O
SJS PROPN B-AC
/ SYM O
TEN PROPN B-AC
lesions NOUN O
display VERB O
a DET O
mixed ADJ O
Th1/ NOUN B-AC
T PROPN B-LF
helper NOUN I-LF
type-2 NOUN I-LF
( PUNCT O
Th2 PROPN B-AC
) PUNCT O
pattern NOUN O
[ PUNCT O
38 NUM O
] PUNCT O
. PUNCT O

* PUNCT O
-refer VERB O
to ADP O
text NOUN O
for ADP O
detailed ADJ O
summary NOUN O
of ADP O
visual ADJ O
impairment/ NOUN O
blindness NOUN O
definitions NOUN O
PXF- NOUN B-AC
Pseudoexfoliation NOUN O
; PUNCT O
OHT NOUN B-AC
- PUNCT O
Ocular NOUN B-LF
hypertension NOUN I-LF
; PUNCT O
PXG NOUN B-AC
- PUNCT O
Pseudoexfoliation NOUN B-LF
glaucoma NOUN I-LF

Mostly ADV O
Upper ADJ B-LF
respiratory ADJ I-LF
tract NOUN I-LF
infection NOUN I-LF
( PUNCT O
URTI PROPN B-AC
) PUNCT O
, PUNCT O
Pneumonia NOUN O
and CCONJ O
acute ADJ O
watery ADJ O
diarrhea NOUN O
received VERB O
antibiotic ADJ O
prescription NOUN O
. PUNCT O

Toll NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
receptors NOUN I-LF
( PUNCT O
TLRs PROPN B-AC
) PUNCT O
are AUX O
a DET O
class NOUN O
of ADP O
proteins NOUN O
that PRON O
play VERB O
a DET O
key ADJ O
role NOUN O
in ADP O
the DET O
innate ADJ O
immune ADJ O
system NOUN O
. PUNCT O

Most ADJ O
circulating VERB O
vitamin NOUN O
D NOUN O
is AUX O
bound VERB O
to ADP O
vitamin NOUN B-LF
D NOUN I-LF
- VERB I-LF
binding VERB I-LF
protein NOUN I-LF
( PUNCT O
VDBP NOUN B-AC
) PUNCT O
( PUNCT O
85~90 NUM O
% PUNCT O
) PUNCT O
or CCONJ O
albumin NOUN O
( PUNCT O
10~15 NUM O
% PUNCT O
) PUNCT O
. PUNCT O

Small ADJ B-LF
ubiquitin NOUN I-LF
- ADV I-LF
like ADJ I-LF
modifiers NOUN I-LF
( PUNCT O
SUMOs PROPN B-AC
) PUNCT O
conjugate VERB O
to ADP O
proteins NOUN O
post ADV O
- ADV O
translationally ADV O
, PUNCT O
thereby ADV O
affecting VERB O
target NOUN O
localization NOUN O
, PUNCT O
activity NOUN O
and CCONJ O
stability NOUN O
. PUNCT O

6 NUM B-LF
- PUNCT I-LF
bromoindirubin-3`-oxime NOUN I-LF
( PUNCT O
BIO PROPN B-AC
) PUNCT O
was AUX O
purchased VERB O
from ADP O
Wako PROPN O
( PUNCT O
Japan PROPN O
) PUNCT O
. PUNCT O

Lipoprotein NOUN B-LF
- PUNCT I-LF
deficient ADJ I-LF
serum NOUN I-LF
( PUNCT O
LPDS PROPN B-AC
) PUNCT O
was AUX O
prepared VERB O
from ADP O
FBS PROPN B-AC
by ADP O
ultracentrifugation NOUN O
at ADP O
a DET O
density NOUN O
of ADP O
1.21 NUM O
kg NOUN O
/ SYM O
L. NOUN O

LFP PROPN B-AC
, PUNCT O
local ADJ B-LF
field NOUN I-LF
potential NOUN I-LF
; PUNCT O
MUA PROPN B-AC
, PUNCT O
multi ADJ B-LF
- ADJ I-LF
unit ADJ I-LF
activity NOUN I-LF
. PUNCT O

The DET O
topic NOUN O
of ADP O
the DET O
end NOUN B-LF
- PUNCT I-LF
of ADP I-LF
- PUNCT I-LF
life NOUN I-LF
( PUNCT O
EOL PROPN B-AC
) PUNCT O
healthcare NOUN O
costs NOUN O
for ADP O
cancer NOUN O
patients NOUN O
has AUX O
been AUX O
frequently ADV O
discussed VERB O
and CCONJ O
researched VERB O
primarily ADV O
using VERB O
health NOUN O
administrative ADJ O
data NOUN O
since SCONJ O
2000 NUM O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

This PRON O
is AUX O
a DET O
meta NOUN O
- NOUN O
research NOUN O
study NOUN O
investigating VERB O
the DET O
evolution NOUN O
of ADP O
the DET O
quality NOUN O
of ADP O
reporting NOUN O
and CCONJ O
key ADJ O
methods NOUN O
of ADP O
randomized VERB B-LF
controlled ADJ I-LF
trials NOUN I-LF
( PUNCT O
RCTs NOUN B-AC
) PUNCT O
using VERB O
meta NOUN O
- NOUN O
data NOUN O
from ADP O
a DET O
huge ADJ O
number NOUN O
of ADP O
published VERB O
RCTs NOUN B-AC
. PUNCT O
To PART O
handle VERB O
such DET O
an DET O
impressive ADJ O
number NOUN O
of ADP O
articles NOUN O
( PUNCT O
> PUNCT O
175,000 NUM O
) PUNCT O
, PUNCT O
the DET O
author NOUN O
relied VERB O
on ADP O
the DET O
use NOUN O
of ADP O
machine NOUN O
learning NOUN O
( PUNCT O
ML PROPN O
) PUNCT O
algorithms NOUN O
to PART O
extract VERB O
relevant ADJ O
data NOUN O
. PUNCT O

Humanity NOUN O
is AUX O
faced VERB O
with ADP O
an DET O
unprecedented ADJ O
challenge NOUN O
— PUNCT O
the DET O
severe ADJ B-LF
acute ADJ I-LF
respiratory ADJ I-LF
syndrome NOUN I-LF
coronavirus NOUN I-LF
2 NUM I-LF
( PUNCT O
SARS PROPN B-AC
- PUNCT B-AC
CoV-2 PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
causes VERB O
a DET O
severe ADJ O
respiratory ADJ O
illness NOUN O
— PUNCT O
coronavirus NOUN O
disease NOUN O
2019 NUM O
( PUNCT O
COVID-19 NOUN O
) PUNCT O
pandemic NOUN O
. PUNCT O

Tikur PROPN B-LF
Anbessa PROPN I-LF
Specialized PROPN I-LF
Hospital PROPN I-LF
( PUNCT O
TASH PROPN B-AC
) PUNCT O
is AUX O
a DET O
tertiary ADJ O
care NOUN O
teaching NOUN O
hospital NOUN O
in ADP O
Addis PROPN O
Ababa PROPN O
, PUNCT O
Ethiopia PROPN O
, PUNCT O
with ADP O
over ADP O
700 NUM O
beds NOUN O
. PUNCT O

The DET O
HPLC PROPN B-AC
- PUNCT O
reverse ADJ O
phase NOUN O
column NOUN O
was AUX O
calibrated VERB O
with ADP O
acetyl NOUN B-AC
- PUNCT B-AC
CoA NOUN B-AC
( PUNCT O
Sigma PROPN O
, PUNCT O
A2056 NUM O
) PUNCT O
and CCONJ O
coenzyme NOUN B-LF
A NOUN I-LF
( PUNCT O
Sigma PROPN O
, PUNCT O
C3144 NUM O
) PUNCT O
. PUNCT O

( PUNCT O
A X O
) PUNCT O
RFS PROPN B-AC
stratified VERB O
by ADP O
baseline ADJ O
ctDNA PROPN B-AC
MAF PROPN B-AC
quartiles NOUN O
; PUNCT O
MAF PROPN B-AC
cut NOUN O
- PUNCT O
offs NOUN O
: PUNCT O
Q1 NOUN O
≤ SYM O
0.15 NUM O
, PUNCT O
Q2 NOUN O
> SYM O
0.15 NUM O
and CCONJ O
≤ SYM O
1.04 NUM O
, PUNCT O
Q3 NOUN O
> SYM O
1.04 NUM O
and CCONJ O
≤ SYM O
7.2 NUM O
, PUNCT O
Q4 NOUN O
> SYM O
7.2 NUM O
. PUNCT O
( PUNCT O
B X O
) PUNCT O
Swimmer ADJ O
plot NOUN O
showing VERB O
serial ADJ O
ctDNA PROPN B-AC
detectability NOUN O
and CCONJ O
clinical ADJ O
outcomes NOUN O
for ADP O
patients NOUN O
in ADP O
cohort NOUN O
1 NUM O
and CCONJ O
2 NUM O
. PUNCT O
( PUNCT O
C X O
) PUNCT O
RFS PROPN B-AC
according VERB O
to ADP O
serial ADJ O
baseline ADJ O
and CCONJ O
postoperative ADJ O
ctDNA PROPN B-AC
status NOUN O
. PUNCT O
ctDNA PROPN B-AC
, PUNCT O
circulating VERB B-LF
tumor NOUN I-LF
DNA NOUN I-LF
; PUNCT O
MAF PROPN B-AC
, PUNCT O
mutant ADJ B-LF
allele NOUN I-LF
fraction NOUN I-LF
; PUNCT O
RFS PROPN B-AC
, PUNCT O
recurrence NOUN B-LF
- PUNCT I-LF
free ADJ I-LF
survival NOUN I-LF
. PUNCT O

Eugonadal ADJ O
men NOUN O
with ADP O
iron NOUN B-LF
- PUNCT I-LF
deficiency NOUN I-LF
anemia NOUN I-LF
( PUNCT O
IDA PROPN B-AC
) PUNCT O
who PRON O
received VERB O
intravenous ADJ O
iron NOUN O
therapy NOUN O
( PUNCT O
800~1200 NUM O
mg NOUN O
elemental ADJ O
iron NOUN O
) PUNCT O
for ADP O
12 NUM O
weeks NOUN O
exhibited VERB O
increased VERB O
levels NOUN O
of ADP O
testosterone NOUN O
, PUNCT O
luteinizing VERB B-LF
hormone NOUN I-LF
( PUNCT O
LH PROPN B-AC
) PUNCT O
, PUNCT O
follicle NOUN B-LF
- PUNCT I-LF
stimulating VERB I-LF
hormone NOUN I-LF
( PUNCT O
FSH PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
sperm NOUN O
parameters NOUN O
[ PUNCT O
8 NUM O
] PUNCT O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
BMI PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
DM1 NOUN B-AC
, PUNCT O
diabetes NOUN B-LF
type NOUN I-LF
1 NUM I-LF
; PUNCT O
DM2 NOUN B-AC
, PUNCT O
diabetes NOUN B-LF
type NOUN I-LF
2 NUM I-LF
; PUNCT O
GDM NOUN B-AC
, PUNCT O
gestational ADJ B-LF
diabetes NOUN I-LF
; PUNCT O
OR NOUN B-AC
, PUNCT O
odds NOUN B-LF
ratio NOUN I-LF
; PUNCT O
PE NOUN B-AC
, PUNCT O
preeclampsia NOUN B-LF
; PUNCT O
PGDM NOUN B-AC
, PUNCT O
pregestational ADJ O
diabetes NOUN O
; PUNCT O
PR NOUN B-AC
, PUNCT O
prevalence NOUN B-LF
ratio NOUN I-LF
; PUNCT O
RR PROPN B-AC
, PUNCT O
risk NOUN B-LF
ratio NOUN I-LF
. PUNCT O

HF PROPN B-AC
entry NOUN O
into ADP O
anagen PROPN O
requires VERB O
the DET O
activation NOUN O
of ADP O
HF PROPN B-AC
- PUNCT B-AC
SCs NOUN B-AC
and CCONJ O
of ADP O
progenitors NOUN O
located VERB O
in ADP O
the DET O
secondary ADJ O
hair NOUN B-LF
germ NOUN I-LF
( PUNCT O
HG PROPN B-AC
) PUNCT O
that PRON O
expand VERB O
to ADP O
give VERB O
rise NOUN O
to ADP O
a DET O
new ADJ O
anagen PROPN O
HF PROPN B-AC
[ X O
17]–[19 X O
] PUNCT O
. PUNCT O

DIC PROPN B-AC
, PUNCT O
decline NOUN B-LF
in ADP I-LF
intrinsic ADJ I-LF
capacity NOUN I-LF
; PUNCT O
ICD PROPN O
-0 NUM O
, PUNCT O
International PROPN O
Classification PROPN O
of ADP O
Diseases–10thRevision PROPN O
; PUNCT O
SD NOUN O
, PUNCT O
standard ADJ O
deviation NOUN O
. PUNCT O

synthetic ADJ B-LF
UniSp6 PROPN I-LF
RNA NOUN I-LF
spike NOUN I-LF
- PUNCT I-LF
in NOUN I-LF

RT NOUN B-AC
- PUNCT B-AC
qPCR NOUN B-AC
, PUNCT O
quantitative ADJ B-LF
real ADJ I-LF
- PUNCT I-LF
time NOUN I-LF
PCR NOUN I-LF
. PUNCT O

The DET O
National PROPN B-LF
Lung PROPN I-LF
Screening PROPN I-LF
Trial PROPN I-LF
( PUNCT O
NLST PROPN B-AC
) PUNCT O
showed VERB O
that SCONJ O
screening NOUN O
with ADP O
low ADJ O
- PUNCT O
dose NOUN O
computed VERB B-LF
tomography NOUN I-LF
( PUNCT O
CT NOUN B-AC
) PUNCT O
can AUX O
reduce VERB O
lung NOUN O
cancer NOUN O
mortality NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

pRNFL PROPN B-AC
: PUNCT O
peripapillary ADJ B-LF
retinal ADJ I-LF
nerve NOUN I-LF
fiber NOUN I-LF
layer NOUN I-LF
; PUNCT O
TML PROPN B-AC
: PUNCT O
total ADJ B-LF
macular ADJ I-LF
layer NOUN I-LF
; PUNCT O
mRNFL PROPN B-AC
: PUNCT O
macular ADJ B-LF
retinal ADJ I-LF
nerve NOUN I-LF
fiber NOUN I-LF
layer NOUN I-LF
; PUNCT O
mGCL PROPN B-AC
: PUNCT O
macular ADJ B-LF
ganglion NOUN I-LF
cell NOUN I-LF
layer NOUN I-LF
; PUNCT O
Temp NOUN O
- PUNCT O
sup NOUN O
: PUNCT O
temporal ADJ O
- PUNCT O
superior ADJ O
; PUNCT O
Temp NOUN O
- PUNCT O
inf NOUN O
: PUNCT O
temporal ADJ O
- PUNCT O
inferior ADJ O
; PUNCT O
Nas NOUN O
- PUNCT O
sup NOUN O
: PUNCT O
nasal ADJ O
- PUNCT O
superior ADJ O
; PUNCT O
Nas NOUN O
- PUNCT O
inf NOUN O
: PUNCT O
nasal ADJ O
- PUNCT O
inferior ADJ O
; PUNCT O
SIM PROPN B-AC
: PUNCT O
superior ADJ O
inner ADJ O
macula NOUN O
; PUNCT O
IIM PROPN B-AC
: PUNCT O
inferior ADJ O
inner ADJ O
macula NOUN O
; PUNCT O
SOM PROPN B-AC
: PUNCT O
superior ADJ O
outer ADJ O
macula NOUN O
; PUNCT O
IOM PROPN B-AC
: PUNCT O
inferior ADJ O
outer ADJ O
macula NOUN O
; PUNCT O
AUROC PROPN B-AC
: PUNCT O
area NOUN O
under ADP O
the DET O
receiver NOUN O
operating NOUN O
characteristic NOUN O
; PUNCT O
CI PROPN O
: PUNCT O
confidence NOUN O
interval NOUN O
. PUNCT O

CAA PROPN B-AC
, PUNCT O
casamino NOUN B-LF
acid NOUN I-LF
medium NOUN I-LF
; PUNCT O
CAS PROPN B-AC
, PUNCT O
casein NOUN B-LF
medium NOUN I-LF
; PUNCT O
CFU PROPN O
, PUNCT O
colony NOUN O
forming VERB O
units NOUN O
; PUNCT O
LB PROPN B-AC
, PUNCT O
Lysogeny PROPN B-LF
broth NOUN I-LF
; PUNCT O
OD600 PROPN B-AC
, PUNCT O
optical ADJ B-LF
density NOUN I-LF
at ADP I-LF
600 NUM I-LF
nm NOUN I-LF
. PUNCT O

Sections NOUN O
were AUX O
blocked VERB O
with ADP O
5 NUM O
% NOUN O
donkey NOUN O
- ADJ O
serum NOUN O
(= PUNCT O
host NOUN O
of ADP O
secondary ADJ O
antibody NOUN B-LF
, PUNCT O
Sigma PROPN O
) PUNCT O
for ADP O
30 NUM O
min NOUN O
at ADP O
room NOUN B-LF
temperature NOUN I-LF
( PUNCT O
RT PROPN B-AC
) PUNCT O
and CCONJ O
incubated VERB O
with ADP O
primary ADJ O
antibodies NOUN O
( PUNCT O
AB PROPN B-AC
) PUNCT O
for ADP O
insulin NOUN O
( PUNCT O
C27C9 NOUN O
) PUNCT O
or CCONJ O
glucagon NOUN O
( PUNCT O
D16G10 NOUN O
, PUNCT O
both PRON O
rabbit ADJ O
monoclonal ADJ O
AB PROPN B-AC
, PUNCT O
Cell PROPN O
Signaling PROPN O
, PUNCT O
Cambridge PROPN O
, PUNCT O
UK PROPN O
) PUNCT O
for ADP O
60 NUM O
min NOUN O
at ADP O
RT PROPN B-AC
. PUNCT O
Slides NOUN O
were AUX O
washed VERB O
thrice ADV O
and CCONJ O
incubated VERB O
with ADP O
secondary ADJ O
AB PROPN B-AC
( PUNCT O
711 NUM O
- ADJ O
035 NUM O
- ADJ O
152 NUM O
, PUNCT O
donkey NOUN O
anti ADJ O
- ADJ O
rabbit ADJ O
polyclonal ADJ O
AB PROPN B-AC
, PUNCT O
Dianova PROPN O
, PUNCT O
Hamburg PROPN O
, PUNCT O
Germany PROPN O
) PUNCT O
for ADP O
30 NUM O
min NOUN O
at ADP O
RT PROPN B-AC
. PUNCT O
Staining NOUN O
was AUX O
performed VERB O
with ADP O
DAB PROPN O
Peroxidase PROPN O
Substrate PROPN O
Kit PROPN O
( PUNCT O
Liquid PROPN O
DAB+Substrate PROPN O
Chromogen PROPN O
System PROPN O
, PUNCT O
Dako PROPN O
) PUNCT O
, PUNCT O
following VERB O
instructions NOUN O
of ADP O
the DET O
manufacturer NOUN O
. PUNCT O

TEM NOUN B-AC
, PUNCT O
transmission NOUN B-LF
electron NOUN I-LF
microscopy NOUN I-LF
. PUNCT O

We PRON O
reasoned VERB O
that SCONJ O
impaired ADJ O
snRNA NOUN O
3′ NUM O
end NOUN O
cleavage NOUN O
should AUX O
increase VERB O
the DET O
levels NOUN O
of ADP O
pre ADJ B-AC
- PUNCT B-AC
snRNAs NOUN B-AC
. PUNCT O
From ADP O
~ NUM O
500 NUM O
T NOUN O
- PUNCT O
DNA NOUN O
insertion NOUN O
lines NOUN O
, PUNCT O
we PRON O
identified VERB O
a DET O
mutant NOUN O
( PUNCT O
Salk_036641C NOUN O
) PUNCT O
containing VERB O
elevated ADJ O
levels NOUN O
of ADP O
pre ADJ O
- PUNCT O
U2.3 ADJ O
snRNA NOUN O
relative ADJ O
to ADP O
wild ADJ O
- PUNCT O
type NOUN O
plants NOUN O
( PUNCT O
WT PROPN B-AC
; PUNCT O
Columbia-0 PROPN B-LF
[ SYM O
Col PROPN B-AC
] PUNCT O
) PUNCT O
through ADP O
reverse ADJ B-LF
transcription NOUN I-LF
PCR PROPN I-LF
( PUNCT O
RT PROPN B-AC
- PUNCT B-AC
PCR PROPN B-AC
) PUNCT O
analyses NOUN O
( PUNCT O
Fig PROPN O
1A NOUN O
and CCONJ O
S1 PROPN O
Data PROPN O
) PUNCT O
. PUNCT O

The DET O
clade NOUN O
B PROPN O
New PROPN B-LF
World PROPN I-LF
arenaviruses NOUN I-LF
( PUNCT O
NWAs PROPN B-AC
) PUNCT O
, PUNCT O
including VERB O
Junín PROPN O
and CCONJ O
Machupo PROPN O
viruses NOUN O
— PUNCT O
the DET O
causative ADJ O
agents NOUN O
of ADP O
Argentine ADJ O
and CCONJ O
Bolivian ADJ O
hemorrhagic ADJ O
fever NOUN O
, PUNCT O
respectively ADV O
— PUNCT O
use VERB O
human ADJ O
but CCONJ O
not PART O
mouse NOUN O
( PUNCT O
Mus PROPN O
) PUNCT O
transferrin NOUN B-LF
receptor NOUN I-LF
1 NUM I-LF
( PUNCT O
TfR1 PROPN B-AC
) PUNCT O
for ADP O
cell NOUN O
entry NOUN O
[ PUNCT O
2 NUM O
] PUNCT O
, PUNCT O
whereas SCONJ O
the DET O
Old PROPN B-LF
World PROPN I-LF
arenaviruses NOUN I-LF
( PUNCT O
OWAs PROPN B-AC
) PUNCT O
Lassa PROPN O
virus NOUN O
and CCONJ O
lymphocytic ADJ B-LF
choriomeningitis NOUN I-LF
virus NOUN I-LF
( PUNCT O
LCMV PROPN B-AC
) PUNCT O
use VERB O
alpha NOUN O
- PUNCT O
dystroglycan NOUN O
[ PUNCT O
3 NUM O
] PUNCT O
. PUNCT O

Anc PROPN O
, PUNCT O
ancestral ADJ O
lys− NOUN O
strain NOUN O
; PUNCT O
ECM21 PROPN B-AC
, PUNCT O
extracellular ADJ B-LF
mutant NOUN I-LF
gene NOUN I-LF
21 NUM I-LF
; PUNCT O
Evo PROPN O
, PUNCT O
an DET O
evolved VERB O
lys− NOUN O
strain NOUN O
; PUNCT O
GSH PROPN B-AC
, PUNCT O
reduced VERB B-LF
glutathione NOUN I-LF
; PUNCT O
HPLC PROPN B-AC
, PUNCT O
High PROPN B-LF
- PUNCT I-LF
Performance PROPN I-LF
Liquid PROPN I-LF
Chromatography PROPN I-LF
; PUNCT O
lys− NOUN O
, PUNCT O
lysine NOUN O
- PUNCT O
requiring VERB O
mutant NOUN O
; PUNCT O
T2 PROPN O
, PUNCT O
doubling VERB O
time NOUN O
. PUNCT O

The DET O
incidence NOUN O
of ADP O
surgery NOUN O
- PUNCT O
related VERB O
AE PROPN B-AC
- PUNCT B-AC
IPF PROPN B-AC
or CCONJ O
acute ADJ B-LF
respiratory ADJ I-LF
distress NOUN I-LF
syndrome NOUN I-LF
( PUNCT O
ARDS PROPN B-AC
) PUNCT O
was AUX O
significantly ADV O
higher ADJ O
in ADP O
the DET O
LC PROPN B-AC
with ADP O
IPF PROPN B-AC
group NOUN O
than ADP O
in ADP O
the DET O
LC PROPN B-AC
without ADP O
IPF PROPN B-AC
group NOUN O
. PUNCT O

Here ADV O
we PRON O
use VERB O
all DET O
- PUNCT O
atom NOUN O
molecular ADJ B-LF
dynamics NOUN I-LF
( PUNCT O
MD NOUN B-AC
) PUNCT O
simulations NOUN O
to PART O
study VERB O
transport NOUN O
of ADP O
single ADJ O
cations NOUN O
through ADP O
the DET O
charge NOUN O
- PUNCT O
selective ADJ O
channel NOUN O
of ADP O
the DET O
nicotinic ADJ B-LF
acetylcholine NOUN I-LF
receptor NOUN I-LF
( PUNCT O
nAChR PROPN B-AC
) PUNCT O
from ADP O
the DET O
motor NOUN O
endplate NOUN O
. PUNCT O

Anthropometric ADJ O
and CCONJ O
metabolic ADJ O
risk NOUN O
factors NOUN O
for ADP O
all DET O
- PUNCT O
cause NOUN O
end NOUN B-LF
- PUNCT I-LF
stage NOUN I-LF
renal ADJ I-LF
disease NOUN I-LF
( PUNCT O
ESRD PROPN B-AC
) PUNCT O
may AUX O
vary VERB O
in ADP O
their PRON O
impact NOUN O
depending VERB O
on ADP O
the DET O
specific ADJ O
primary ADJ O
renal ADJ O
disease NOUN O
. PUNCT O

FAME PROPN B-AC
, PUNCT O
fatty ADJ B-LF
acid NOUN I-LF
methyl NOUN I-LF
ester NOUN I-LF
; PUNCT O
M PROPN O
/ PROPN O
LCFA PROPN B-AC
, PUNCT O
medium- ADJ O
and CCONJ O
long ADJ B-LF
- PUNCT I-LF
chain NOUN I-LF
fatty ADJ I-LF
acid NOUN I-LF
; PUNCT O
NEFA PROPN B-AC
, PUNCT O
nonesterified ADJ B-LF
fatty ADJ I-LF
acid NOUN I-LF
; PUNCT O
Pex PROPN O
, PUNCT O
peroxin NOUN O
; PUNCT O
TMRE PROPN B-AC
, PUNCT O
tetramethylrhodamine NOUN B-LF
ethyl NOUN I-LF
ester NOUN I-LF
. PUNCT O

Abnormal ADJ O
RVOT PROPN B-AC
was AUX O
defined VERB O
as ADP O
the DET O
presence NOUN O
of ADP O
RVOT PROPN B-AC
regional ADJ B-LF
wall NOUN I-LF
motion NOUN I-LF
abnormalities NOUN I-LF
( PUNCT O
RWMA PROPN B-AC
; PUNCT O
defined VERB O
as ADP O
akinesis NOUN O
, PUNCT O
dyskinesis NOUN O
) PUNCT O
or CCONJ O
an DET O
RVOT PROPN B-AC
diameter NOUN O
> ADP O
25mm[22 NUM O
] PUNCT O
. PUNCT O

MIHR PROPN B-AC
, PUNCT O
MIH PROPN B-LF
receptor NOUN I-LF
. PUNCT O

Lipid NOUN O
membranes NOUN O
were AUX O
prepared VERB O
from ADP O
cholesterol NOUN B-LF
( PUNCT O
CHOL PROPN B-AC
) PUNCT O
, PUNCT O
1 NUM B-LF
- PUNCT I-LF
palmitoyl-2 NOUN I-LF
- PUNCT I-LF
oleoyl NOUN I-LF
- PUNCT I-LF
sn NOUN I-LF
- PUNCT I-LF
glycero-3 NOUN I-LF
- PUNCT I-LF
phospho NOUN I-LF
- PUNCT I-LF
L NOUN I-LF
- PUNCT I-LF
serine NOUN I-LF
( PUNCT O
POPS PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
1,2 NUM B-LF
- PUNCT I-LF
dipalmitoyl NOUN I-LF
- PUNCT I-LF
sn NOUN I-LF
- PUNCT I-LF
glycero-3 NOUN I-LF
- PUNCT I-LF
phosphocholine NOUN I-LF
( PUNCT O
PC PROPN B-AC
) PUNCT O
at ADP O
1:7:2 NUM O
, PUNCT O
respectively ADV O
. PUNCT O

AhR PROPN B-AC
activation NOUN O
increases VERB O
detoxification NOUN O
to PART O
protect VERB O
the DET O
organism NOUN O
from ADP O
xenobiotic ADJ O
exposure NOUN O
by ADP O
influencing VERB O
the DET O
gene NOUN O
expression NOUN O
and CCONJ O
activity NOUN O
of ADP O
efflux ADJ O
transporters NOUN O
, PUNCT O
such ADJ O
as ADP O
the DET O
ABCG2 PROPN B-AC
transporter NOUN O
( PUNCT O
ATP NOUN B-LF
- PUNCT I-LF
binding VERB I-LF
cassette NOUN I-LF
subfamily NOUN I-LF
G PROPN I-LF
2 NUM I-LF
, PUNCT O
Breast PROPN B-LF
Cancer PROPN I-LF
Resistance PROPN I-LF
Protein PROPN I-LF
, PUNCT O
BCRP PROPN B-AC
) PUNCT O
[ PUNCT O
11,16–18 NUM O
] PUNCT O
. PUNCT O

Physical ADJ B-LF
activity NOUN I-LF
( PUNCT O
PA NOUN B-AC
) PUNCT O
and CCONJ O
diet NOUN O
are AUX O
the DET O
modifiable ADJ O
lifestyle NOUN O
behaviors NOUN O
that PRON O
play VERB O
significant ADJ O
roles NOUN O
in ADP O
achieving VERB O
and CCONJ O
maintaining VERB O
energy NOUN O
balance NOUN O
for ADP O
both CCONJ O
treatment NOUN O
and CCONJ O
prevention NOUN O
of ADP O
obesity NOUN O
[ PUNCT O
7,8 NUM O
] PUNCT O
. PUNCT O

Ark1 PROPN O
, PUNCT O
aurora NOUN O
- PUNCT O
related VERB O
kinase NOUN O
1 NUM O
; PUNCT O
Brca1 PROPN B-AC
, PUNCT O
breast NOUN B-LF
cancer NOUN I-LF
type NOUN I-LF
1 NUM I-LF
susceptibility NOUN I-LF
protein NOUN I-LF
; PUNCT O
Cep112 PROPN B-AC
, PUNCT O
centrosomal ADJ B-LF
protein NOUN I-LF
112 NUM I-LF
; PUNCT O
Gapdh PROPN O
, PUNCT O
glyceride NOUN O
3 NUM O
- PUNCT O
phosphate NOUN O
dehydrogenase NOUN O
; PUNCT O
siRNA NOUN O
, PUNCT O
small ADJ O
interfering VERB O
RNA NOUN O
. PUNCT O

We PRON O
evaluated VERB O
the DET O
assay NOUN O
precision NOUN O
, PUNCT O
according VERB O
to ADP O
the DET O
guideline NOUN O
of ADP O
The PRON B-LF
Clinical PROPN I-LF
& CCONJ I-LF
Laboratory PROPN I-LF
Standards PROPN I-LF
Institute PROPN I-LF
( PUNCT O
CLSI PROPN B-AC
) PUNCT O
documents NOUN O
EP15 PROPN O
- SYM O
A3 NOUN O
[ PUNCT O
21 NUM O
] PUNCT O
. PUNCT O

Understanding VERB O
geographic ADJ O
inequalities NOUN O
in ADP O
coverage NOUN O
of ADP O
drinking NOUN O
- PUNCT O
water NOUN B-LF
supply NOUN I-LF
and CCONJ I-LF
sanitation NOUN I-LF
( PUNCT O
WSS PROPN B-AC
) PUNCT O
will AUX O
help VERB O
track VERB O
progress NOUN O
towards ADP O
universal ADJ O
coverage NOUN O
of ADP O
water NOUN O
and CCONJ O
sanitation NOUN O
by ADP O
identifying VERB O
marginalized VERB O
populations NOUN O
, PUNCT O
thus ADV O
helping VERB O
to PART O
control VERB O
a DET O
large ADJ O
number NOUN O
of ADP O
infectious ADJ O
diseases NOUN O
. PUNCT O

Brca1 PROPN B-AC
, PUNCT O
breast NOUN B-LF
cancer NOUN I-LF
type NOUN I-LF
1 NUM I-LF
susceptibility NOUN I-LF
protein NOUN I-LF
; PUNCT O
Cep112 PROPN B-AC
, PUNCT O
centrosomal ADJ B-LF
protein NOUN I-LF
112 NUM I-LF
; PUNCT O
FAM PROPN B-AC
, PUNCT O
fluorescein NOUN B-LF
amidite NOUN I-LF
; PUNCT O
Ginir PROPN B-AC
, PUNCT O
Genomic PROPN B-LF
Instability PROPN I-LF
Inducing PROPN I-LF
RNA NOUN I-LF
; PUNCT O
IgG PROPN O
, PUNCT O
immunoglobulin NOUN O
G PROPN O
; PUNCT O
IP PROPN O
, PUNCT O
immunoprecipitation NOUN O
; PUNCT O
RIP PROPN B-AC
, PUNCT O
RNA NOUN B-LF
- PUNCT I-LF
immunoprecipitation NOUN I-LF
; PUNCT O
RNasin PROPN B-AC
, PUNCT O
RNase NOUN B-LF
inhibitor NOUN I-LF
; PUNCT O
RT PROPN B-AC
- PUNCT B-AC
PCR PROPN B-AC
, PUNCT O
reverse ADJ O
transcription NOUN O
polymerase NOUN B-LF
chain NOUN I-LF
reaction NOUN I-LF
; PUNCT O
snRNA NOUN B-AC
, PUNCT O
small ADJ B-LF
nuclear ADJ I-LF
RNA NOUN I-LF
. PUNCT O

COPD NOUN B-AC
= VERB O
chronic ADJ B-LF
obstructive ADJ I-LF
pulmonary ADJ I-LF
disease NOUN I-LF
; PUNCT O
e NOUN O
= VERB O
exacerbations NOUN O
. PUNCT O

Several ADJ O
U.S. PROPN O
based VERB O
studies NOUN O
report NOUN O
treatment NOUN O
rates NOUN O
with ADP O
pegylated NOUN B-LF
- PUNCT I-LF
interferon NOUN I-LF
( PUNCT O
PEG PROPN B-AC
- PUNCT B-AC
IFN PROPN B-AC
) PUNCT O
and CCONJ O
ribavirin NOUN B-LF
( PUNCT O
RBV PROPN B-AC
) PUNCT O
that SCONJ O
range VERB O
from ADP O
nine NUM O
to ADP O
36%.[3–7 NUM O
] PUNCT O
In ADP O
their PRON O
report NOUN O
the DET O
WHO PROPN B-AC
also ADV O
estimates VERB O
that SCONJ O
under ADP O
1 NUM O
% NOUN O
of ADP O
treatment NOUN O
eligible ADJ O
CHC PROPN B-AC
patients NOUN O
worldwide ADV O
have AUX O
received VERB O
antiviral ADJ O
therapy.[2 NOUN O
] PUNCT O

Next ADV O
, PUNCT O
the DET O
diabetic ADJ O
rats NOUN O
were AUX O
randomly ADV O
divided VERB O
into ADP O
three NUM O
groups NOUN O
: PUNCT O
diabetes NOUN B-LF
mellitus NOUN I-LF
( PUNCT O
DM PROPN B-AC
) PUNCT O
group NOUN O
( PUNCT O
n NOUN O
= SYM O
6 NUM O
) PUNCT O
, PUNCT O
Ad PROPN O
- PUNCT O
Sik1 PROPN O
group NOUN O
( PUNCT O
n NOUN O
= SYM O
8) NUM O
, PUNCT O
and CCONJ O
Ad PROPN B-AC
- PUNCT B-AC
GFP PROPN B-AC
group NOUN O
( PUNCT O
n NOUN O
= SYM O
6 NUM O
) PUNCT O
. PUNCT O

There PRON O
are VERB O
two NUM O
previously ADV O
reported VERB O
transcription NOUN O
factors NOUN O
that PRON O
utilize VERB O
Prox1 PROPN O
as ADP O
co NOUN O
- NOUN O
repressor NOUN O
via ADP O
direct ADJ O
interactions NOUN O
to ADP O
suppress VERB O
gene NOUN O
expression NOUN O
in ADP O
other ADJ O
systems NOUN O
, PUNCT O
NR5A2 PROPN B-AC
( PUNCT O
Nuclear PROPN B-LF
Receptor PROPN I-LF
5A2 PROPN I-LF
) PUNCT O
and CCONJ O
SF1 PROPN B-AC
( PUNCT O
Steroidogenic PROPN B-LF
Factor PROPN I-LF
1 NUM I-LF
) PUNCT O
, PUNCT O
both PRON O
belonging VERB O
to ADP O
the DET O
family NOUN O
of ADP O
orphan ADJ O
nuclear ADJ O
receptors NOUN O
[ X O
34]–[36 X O
] PUNCT O
. PUNCT O

Data NOUN O
on ADP O
age NOUN O
, PUNCT O
sex NOUN O
, PUNCT O
and CCONJ O
SNAP PROPN B-AC
participation NOUN O
status NOUN O
were AUX O
acquired VERB O
from ADP O
the DET O
National PROPN B-LF
Health PROPN I-LF
Interview PROPN I-LF
Survey PROPN I-LF
( PUNCT O
NHIS PROPN B-AC
) PUNCT O
, PUNCT O
2000–2009 NUM O
. PUNCT O

Orthologs NOUN O
contrast VERB O
to ADP O
paralogs NOUN O
, PUNCT O
i.e. X O
, PUNCT O
genes NOUN O
that PRON O
diverged VERB O
by ADP O
gene NOUN O
duplication NOUN O
, PUNCT O
and CCONJ O
xenologs NOUN O
, PUNCT O
i.e. X O
, PUNCT O
homologous ADJ O
genes NOUN O
whose DET O
history NOUN O
of ADP O
divergence NOUN O
includes VERB O
one NUM O
or CCONJ O
more ADJ O
horizontal ADJ B-LF
gene NOUN I-LF
transfer NOUN I-LF
( PUNCT O
HGT PROPN B-AC
) PUNCT O
events NOUN O
. PUNCT O

Heterogeneity NOUN B-LF
was AUX O
measured VERB O
by ADP O
I2 PROPN B-AC
statistics NOUN O
( PUNCT O
I2>50 NUM B-AC
% NOUN O
was AUX O
regarded VERB O
as ADP O
heterogeneity NOUN B-LF
) PUNCT O
and CCONJ O
Q PROPN O
statistics NOUN O
( PUNCT O
P<0.1 NOUN O
was AUX O
considered VERB O
heterogeneity NOUN B-LF
) PUNCT O
. PUNCT O

Representatives NOUN O
of ADP O
this DET O
cluster NOUN O
included VERB O
Tsukushi PROPN B-LF
( PUNCT O
Tsku PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
is AUX O
a DET O
recently ADV O
identified VERB O
hepatokine NOUN O
that PRON O
can AUX O
regulate VERB O
BAT NOUN B-AC
energy NOUN O
expenditure NOUN O
[ PUNCT O
32 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
Stearoyl PROPN B-LF
- PUNCT I-LF
Coenzyme PROPN I-LF
A PROPN I-LF
Desaturase PROPN I-LF
2 NUM I-LF
( PUNCT O
Scd2 PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
is AUX O
required VERB O
for ADP O
PPARg NOUN B-AC
expression NOUN O
in ADP O
3T3 NOUN O
- PUNCT O
L1 NOUN O
adipose ADJ O
cells NOUN O
[ PUNCT O
33 NUM O
] PUNCT O
. PUNCT O

Class NOUN O
IV NUM O
md NOUN B-AC
neurons NOUN O
can AUX O
be AUX O
identified VERB O
with ADP O
ppkEGFP PROPN O
, PUNCT O
which PRON O
labels VERB O
one NUM O
intersegmental ADJ B-LF
nerve NOUN I-LF
( PUNCT O
ISN PROPN B-AC
) PUNCT O
and CCONJ O
two NUM O
segmental ADJ B-LF
nerve NOUN I-LF
( PUNCT O
SN PROPN B-AC
) PUNCT O
neurons NOUN O
in ADP O
each DET O
hemisegment NOUN O
[ PUNCT O
9],[12 NUM O
] PUNCT O
. PUNCT O

Ct NOUN B-AC
, PUNCT O
cycle NOUN B-LF
threshold NOUN I-LF
; PUNCT O
MuV PROPN B-AC
, PUNCT O
mumps NOUN B-LF
virus NOUN I-LF
; PUNCT O
RT NOUN B-AC
- PUNCT B-AC
qPCR PROPN B-AC
, PUNCT O
real ADJ B-LF
- PUNCT I-LF
time NOUN I-LF
quantitative ADJ I-LF
polymerase NOUN I-LF
chain NOUN I-LF
reaction NOUN I-LF
. PUNCT O

In ADP O
this DET O
study NOUN O
, PUNCT O
we PRON O
utilised VERB O
a DET O
large ADJ O
international ADJ O
registry NOUN O
[ X O
15 NUM O
] X O
of ADP O
intensive ADJ O
care NOUN O
admissions NOUN O
following VERB O
cardiac ADJ O
arrest NOUN O
and CCONJ O
applied VERB O
a DET O
variety NOUN O
of ADP O
ML NOUN B-AC
methods NOUN O
to ADP O
improve VERB O
the DET O
prediction NOUN O
of ADP O
outcomes NOUN O
, PUNCT O
and CCONJ O
compared VERB O
these DET O
methods NOUN O
with ADP O
logistic ADJ B-LF
regression NOUN I-LF
( PUNCT O
LR NOUN B-AC
) PUNCT O
in ADP O
addition NOUN O
to ADP O
existing VERB O
gold ADJ O
standard NOUN O
generic ADJ O
ICU PROPN B-AC
illness NOUN O
severity NOUN O
scores NOUN O
. PUNCT O

Nursing NOUN O
homes NOUN O
were AUX O
allocated VERB O
to ADP O
receive VERB O
either CCONJ O
the DET O
WHELD PROPN O
intervention NOUN O
or CCONJ O
TAU PROPN B-AC
using VERB O
secure ADJ O
web NOUN O
access NOUN O
to ADP O
the DET O
remote ADJ O
randomisation NOUN O
centre NOUN O
at ADP O
the DET O
North PROPN B-LF
Wales PROPN I-LF
Organisation PROPN I-LF
for ADP I-LF
Randomised PROPN I-LF
Trials PROPN I-LF
in ADP I-LF
Health PROPN I-LF
Clinical PROPN I-LF
Trial PROPN I-LF
Unit PROPN I-LF
( PUNCT O
NWORTH PROPN B-AC
CTU PROPN B-AC
) PUNCT O
at ADP O
Bangor PROPN O
University PROPN O
. PUNCT O

We PRON O
considered VERB O
positive ADJ O
cytology NOUN O
as ADP O
: PUNCT O
Atypical PROPN B-LF
Squamous PROPN I-LF
Cells PROPN I-LF
of ADP I-LF
Undetermined PROPN I-LF
Significance NOUN I-LF
( PUNCT O
ASC PROPN B-AC
- PUNCT B-AC
US PROPN B-AC
) PUNCT O
, PUNCT O
Atypical PROPN O
Squamous PROPN O
Cells PROPN O
can AUX O
not AUX O
exclude VERB O
a DET O
High ADJ B-LF
- PUNCT I-LF
grade NOUN I-LF
Squamous PROPN I-LF
Intraepithelial PROPN I-LF
Lesion PROPN I-LF
( PUNCT O
ASC PROPN B-AC
- PUNCT B-AC
H PROPN B-AC
) PUNCT O
, PUNCT O
Low ADJ B-LF
- PUNCT I-LF
grade NOUN I-LF
Squamous PROPN I-LF
Intraepithelial PROPN I-LF
Lesion PROPN I-LF
( PUNCT O
LSIL PROPN B-AC
) PUNCT O
, PUNCT O
High ADJ B-LF
- PUNCT I-LF
grade NOUN I-LF
Squamous PROPN I-LF
Intraepithelial PROPN I-LF
Lesion PROPN I-LF
( PUNCT O
HSIL PROPN B-AC
) PUNCT O
, PUNCT O
AGC PROPN B-AC
( PUNCT O
Atypical PROPN B-LF
Glandular PROPN I-LF
Cells PROPN I-LF
) PUNCT O
, PUNCT O
Atypical PROPN B-LF
Glandular PROPN I-LF
Cells PROPN I-LF
favour VERB O
neoplastic ADJ O
, PUNCT O
endocervical ADJ O
adenocarcinoma NOUN O
in ADP O
situ NOUN O
or CCONJ O
adenocarcinoma NOUN O
. PUNCT O

Oxidative ADJ O
stress NOUN O
was AUX O
induced VERB O
with ADP O
H2O2 NOUN B-AC
for ADP O
an DET O
hour NOUN O
which PRON O
was AUX O
followed VERB O
by ADP O
supplementation NOUN O
with ADP O
different ADJ O
ratios NOUN O
of ADP O
α NOUN B-AC
- PUNCT B-AC
TCP NOUN B-AC
and CCONJ O
tocotrienol NOUN B-LF
- PUNCT I-LF
rich ADJ I-LF
fraction NOUN I-LF
( PUNCT O
TRF NOUN B-AC
) PUNCT O
for ADP O
four NUM O
hours NOUN O
. PUNCT O

Abbreviations NOUN O
; PUNCT O
FLR PROPN B-AC
: PUNCT O
Focal ADJ B-LF
liver NOUN I-LF
reaction NOUN I-LF
; PUNCT O
PBT PROPN B-AC
: PUNCT O
Proton NOUN B-LF
beam NOUN I-LF
therapy NOUN I-LF
. PUNCT O

In ADP O
this DET O
study NOUN O
, PUNCT O
we PRON O
investigated VERB O
the DET O
distribution NOUN O
of ADP O
particular ADJ O
inhibitory ADJ O
GAG PROPN B-AC
chains NOUN O
and CCONJ O
CSPG PROPN B-AC
subtypes NOUN O
within ADP O
multifasciculated ADJ O
peripheral ADJ O
nerves NOUN O
and CCONJ O
their PRON O
susceptibility NOUN O
to ADP O
degradation NOUN O
and CCONJ O
inactivation NOUN O
by ADP O
a DET O
chondroitinase NOUN O
with ADP O
greater ADJ O
specificity NOUN O
than ADP O
the DET O
pan ADJ O
- PUNCT O
specific ADJ O
ChABC PROPN B-AC
. PUNCT O
Here ADV O
we PRON O
provide VERB O
evidence NOUN O
that SCONJ O
the DET O
endoneurial ADJ O
compartment NOUN O
contains VERB O
CSPGs NOUN B-AC
with ADP O
GAG PROPN B-AC
chains NOUN O
that SCONJ O
are AUX O
more ADV O
specifically ADV O
degraded VERB O
by ADP O
chondroitinase NOUN B-LF
C PROPN I-LF
( PUNCT O
ChC PROPN B-AC
) PUNCT O
and CCONJ O
that SCONJ O
ChC PROPN B-AC
selectively ADV O
enhances VERB O
the DET O
axon NOUN O
growth NOUN O
- PUNCT O
promoting VERB O
properties NOUN O
of ADP O
the DET O
endoneurial ADJ O
basal ADJ O
lamina NOUN O
. PUNCT O

Secondly ADV O
, PUNCT O
we PRON O
knocked VERB O
down ADP O
the DET O
expression NOUN O
of ADP O
snn NOUN O
in ADP O
RAW264.7 NUM O
cells NOUN O
using VERB O
siRNAs NOUN B-AC
( PUNCT O
small ADJ B-LF
interfering VERB I-LF
RNAs NOUN I-LF
) PUNCT O
( PUNCT O
S5A NOUN O
and CCONJ O
S5B PROPN O
Fig PROPN O
) PUNCT O
and CCONJ O
monitored VERB O
the DET O
formation NOUN O
of ADP O
acidic ADJ O
compartments NOUN O
with ADP O
Lysotracker PROPN O
. PUNCT O
snn NOUN O
si NOUN O
- PUNCT O
RNA NOUN O
- PUNCT O
treated VERB O
RAW PROPN O
264.7 NUM O
cells NOUN O
showed VERB O
abnormally ADV O
large ADJ O
acidic ADJ O
aggregates NOUN O
( PUNCT O
Fig PROPN O
5A–5C NUM O
) PUNCT O
mimicking VERB O
the DET O
hemo NOUN B-AC
A4 NOUN O
null NOUN O
phenotype NOUN O
observed VERB O
in ADP O
hemocytes NOUN O
( PUNCT O
Fig PROPN O
2A NUM O
” NOUN O
and CCONJ O
2L NUM O
” NOUN O
and CCONJ O
S1G PROPN O
– SYM O
S1 NOUN O
K NOUN O
Fig PROPN O
) PUNCT O
. PUNCT O

CVD NOUN B-AC
, PUNCT O
cardiovascular ADJ B-LF
disease NOUN I-LF
. PUNCT O

For ADP O
descriptive ADJ O
statistics NOUN O
, PUNCT O
continuous ADJ O
variables NOUN O
were AUX O
reported VERB O
as ADP O
medians NOUN O
( PUNCT O
interquartile ADJ B-LF
ranges NOUN I-LF
[ PUNCT O
IQRs NOUN B-AC
] PUNCT O
) PUNCT O
; PUNCT O
categorical ADJ O
variables NOUN O
were AUX O
reported VERB O
as ADP O
percentages NOUN O
. PUNCT O

Directly ADV B-LF
observed VERB I-LF
therapy NOUN I-LF
( PUNCT O
DOT NOUN B-AC
) PUNCT O
is AUX O
the DET O
preferred VERB O
strategy NOUN O
for ADP O
active ADJ O
TB PROPN B-AC
treatment NOUN O
but CCONJ O
requires VERB O
substantial ADJ O
resources NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
AD PROPN B-AC
, PUNCT O
Alzheimer PROPN B-LF
's PART I-LF
disease NOUN I-LF
; PUNCT O
EAE PROPN B-AC
, PUNCT O
experimental ADJ B-LF
autoimmune ADJ I-LF
encephalomyelitis NOUN I-LF
; PUNCT O
FCI PROPN B-AC
, PUNCT O
focal ADJ B-LF
cerebral ADJ I-LF
ischaemia NOUN I-LF
; PUNCT O
PD PROPN O
, PUNCT O
Parkinson PROPN O
's PART O
disease NOUN O
; PUNCT O
SCI PROPN B-AC
, PUNCT O
spinal ADJ O
cord NOUN O
injury NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
IDU PROPN B-AC
, PUNCT O
injection NOUN B-LF
drug NOUN I-LF
use NOUN I-LF
; PUNCT O
OAT PROPN B-AC
, PUNCT O
opioid NOUN B-LF
agonist ADJ I-LF
treatment NOUN I-LF
; PUNCT O
PRIMER PROPN B-AC
, PUNCT O
Preventing VERB B-LF
Injecting VERB I-LF
by ADP I-LF
Modifying VERB I-LF
Existing VERB I-LF
Responses NOUN I-LF

Experiments NOUN O
in ADP O
support NOUN O
of ADP O
this PRON O
showed VERB O
that SCONJ O
the DET O
amount NOUN O
of ADP O
wild ADJ O
- PUNCT O
type NOUN O
DSPP PROPN B-AC
( PUNCT O
IPV PROPN B-AC
) PUNCT O
secreted VERB O
by ADP O
human ADJ B-LF
embryonic ADJ I-LF
kidney NOUN I-LF
cell NOUN I-LF
line NOUN I-LF
293A NOUN I-LF
( PUNCT O
HEK293A PROPN B-AC
) PUNCT O
was AUX O
inversely ADV O
correlated VERB O
with ADP O
increasing VERB O
amounts NOUN O
of ADP O
coexpressed VERB O
mutant ADJ O
protein NOUN O
( PUNCT O
IPD PROPN B-AC
, PUNCT O
isoleucine NOUN B-LF
- PUNCT I-LF
serine NOUN I-LF
- PUNCT I-LF
valine NOUN I-LF
[ PUNCT O
ISV PROPN B-AC
] PUNCT O
, PUNCT O
or CCONJ O
isoleucine NOUN B-LF
- PUNCT I-LF
threonine NOUN I-LF
- PUNCT I-LF
valine NOUN I-LF
[ PUNCT O
ITV]-DSPP PROPN B-AC
) PUNCT O
[ PUNCT O
5 NUM O
] PUNCT O
. PUNCT O

To PART O
further ADV O
investigate VERB O
whether SCONJ O
AMPK PROPN B-AC
modulates VERB O
some DET O
aspect NOUN O
of ADP O
soma NOUN O
- PUNCT O
to ADP O
- PUNCT O
germline NOUN O
communication NOUN O
through ADP O
the DET O
deployment NOUN O
of ADP O
somatically ADV O
derived VERB O
small ADJ O
endogenous ADJ O
RNAs NOUN O
, PUNCT O
we PRON O
tested VERB O
whether SCONJ O
the DET O
double ADJ B-LF
- PUNCT I-LF
stranded ADJ I-LF
RNA NOUN I-LF
( PUNCT O
dsRNA NOUN B-AC
) PUNCT O
importer NOUN O
Systemic PROPN O
RNAi PROPN B-AC
Defective PROPN O
( PUNCT O
sid)-1 PROPN O
could AUX O
affect VERB O
the DET O
PD PROPN B-AC
sterility NOUN O
of ADP O
AMPK PROPN B-AC
mutants NOUN O
by ADP O
impairing VERB O
the DET O
uptake NOUN O
of ADP O
small ADJ O
dsRNAs NOUN B-AC
[ X O
41 NUM O
] PUNCT O
. PUNCT O

Scale NOUN O
bars NOUN O
represent VERB O
25 NUM O
μm NOUN O
. PUNCT O
ac NOUN B-AC
, PUNCT O
anterior ADJ B-LF
commissure NOUN I-LF
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
lvCB PROPN B-AC
, PUNCT O
larval ADJ O
central ADJ O
body NOUN O
; PUNCT O
NS PROPN B-AC
, PUNCT O
neural ADJ B-LF
stage NOUN I-LF
; PUNCT O
Rx NOUN B-AC
, PUNCT O
retinal ADJ O
homeobox NOUN O
. PUNCT O

Montelukast PROPN O
is AUX O
a DET O
leukotriene NOUN B-LF
receptor NOUN I-LF
antagonist NOUN I-LF
( PUNCT O
LTRA NOUN B-AC
) PUNCT O
, PUNCT O
which PRON O
possesses VERB O
anti ADJ O
- ADJ O
inflammatory ADJ O
effects NOUN O
, PUNCT O
especially ADV O
on ADP O
eosinophilic ADJ O
inflammation NOUN O
[ X O
17 NUM O
] X O
and CCONJ O
is AUX O
thought VERB O
to PART O
impact VERB O
on ADP O
airway NOUN O
remodeling NOUN O
. PUNCT O

HCA PROPN B-AC
, PUNCT O
hybrid ADJ B-LF
cellular ADJ I-LF
automata NOUN I-LF
; PUNCT O
RAF PROPN B-AC
, PUNCT O
rapidly ADV B-LF
accelerated VERB I-LF
fibrosarcoma NOUN I-LF
; PUNCT O
RAS PROPN B-AC
, PUNCT O
rat NOUN B-LF
sarcoma NOUN I-LF
. PUNCT O

GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
PAS PROPN B-AC
, PUNCT O
phagophore NOUN B-LF
assembly NOUN I-LF
site NOUN I-LF
; PUNCT O
WT PROPN O
, PUNCT O
wild ADJ O
- PUNCT O
type NOUN O
. PUNCT O

Alternative ADJ O
fragmentation NOUN O
sites NOUN O
tend VERB O
to PART O
map VERB O
between ADP O
predicted VERB O
genes NOUN O
in ADP O
intergenic ADJ O
regions NOUN O
rather ADV O
than ADP O
within ADP O
intragenic ADJ O
regions NOUN O
[ PUNCT O
Table PROPN O
S1 NUM O
; PUNCT O
we PRON O
use VERB O
inter ADJ O
- ADJ O
CDS PROPN B-AC
regions NOUN O
rather ADV O
than ADP O
intergenic ADJ O
regions NOUN O
since SCONJ O
CDS PROPN B-AC
( PUNCT O
coding NOUN B-LF
sequence NOUN I-LF
) PUNCT O
predictions NOUN O
are AUX O
more ADV O
reliable ADJ O
than ADP O
UTRs NOUN B-AC
( PUNCT O
untranslated VERB B-LF
regions NOUN I-LF
) PUNCT O
] PUNCT O
. PUNCT O

Each DET O
unit NOUN O
was AUX O
represented VERB O
by ADP O
a DET O
one NUM B-LF
- PUNCT I-LF
versus ADP I-LF
- PUNCT I-LF
all PRON I-LF
( PUNCT O
OVA NOUN B-AC
) PUNCT O
classifier NOUN O
that DET O
was AUX O
trained VERB O
by ADP O
logistic ADJ O
regression NOUN O
to PART O
report VERB O
the DET O
probability NOUN O
of ADP O
each DET O
stimulus NOUN O
given VERB O
a DET O
single ADJ O
- PUNCT O
trial NOUN O
spike NOUN O
train NOUN O
( PUNCT O
0–150 NUM O
ms NOUN O
after ADP O
stimulus NOUN O
onset NOUN O
, PUNCT O
binned VERB O
using VERB O
either CCONJ O
10 NUM O
ms NOUN O
bins NOUN O
or CCONJ O
a DET O
single ADJ O
fixed VERB O
time NOUN O
bin NOUN O
) PUNCT O
, PUNCT O
selected VERB O
randomly ADV O
from ADP O
recorded VERB O
spike NOUN O
trains NOUN O
for ADP O
that DET O
unit NOUN O
. PUNCT O

On ADP O
very ADV O
rare ADJ O
occasions NOUN O
, PUNCT O
OPV PROPN B-AC
may AUX O
cause VERB O
vaccine NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
paralytic ADJ I-LF
poliomyelitis NOUN I-LF
( PUNCT O
VAPP PROPN B-AC
) PUNCT O
, PUNCT O
at ADP O
a DET O
low ADJ O
rate NOUN O
of ADP O
about ADV O
1–2 NUM O
cases NOUN O
of ADP O
VAPP PROPN B-AC
per ADP O
million NUM O
primary ADJ O
immunisations NOUN O
[ PUNCT O
3 NUM O
] PUNCT O
. PUNCT O

Clinical ADJ O
disease NOUN O
activity NOUN O
was AUX O
documented VERB O
using VERB O
established VERB O
clinical ADJ O
parameters NOUN O
of ADP O
the DET O
Crohn PROPN B-LF
disease NOUN I-LF
activity NOUN I-LF
index NOUN I-LF
( PUNCT O
CDAI PROPN B-AC
) PUNCT O
in ADP O
CD PROPN B-AC
[ X O
15 NUM O
] X O
and CCONJ O
the DET O
colitis NOUN B-LF
activity NOUN I-LF
index NOUN I-LF
( PUNCT O
CAI PROPN B-AC
) PUNCT O
[ X O
16,17 NUM O
] X O
for ADP O
UC PROPN B-AC
patients NOUN O
. PUNCT O

All DET O
these DET O
metabolic ADJ O
disorders NOUN O
can AUX O
be AUX O
associated VERB O
with ADP O
hyperglycaemia NOUN O
and CCONJ O
underlying VERB O
insulin NOUN O
resistance NOUN O
, PUNCT O
and CCONJ O
thereby ADV O
with ADP O
the DET O
metabolic ADJ B-LF
syndrome NOUN I-LF
( PUNCT O
MetS PROPN B-AC
) PUNCT O
[ PUNCT O
23 NUM O
, PUNCT O
24 NUM O
] PUNCT O
. PUNCT O

Additionally ADV O
, PUNCT O
transcriptomes NOUN O
were AUX O
compared VERB O
to ADP O
their PRON O
corresponding ADJ O
genomic ADJ O
sequences NOUN O
as ADP O
a DET O
practical ADJ O
approach NOUN O
for ADP O
the DET O
detection NOUN O
of ADP O
RNA NOUN B-LF
- PUNCT I-LF
DNA NOUN I-LF
differences NOUN I-LF
( PUNCT O
RDDs NOUN B-AC
) PUNCT O
and CCONJ O
identification NOUN O
of ADP O
the DET O
canonical ADJ O
A NOUN O
- PUNCT O
to ADP O
- PUNCT O
I NOUN O
and CCONJ O
C NOUN O
- PUNCT O
to ADP O
- PUNCT O
U NOUN O
RNA NOUN O
editing NOUN O
sites NOUN O
in ADP O
diverse ADJ O
eukaryotes NOUN O
[ PUNCT O
6 NUM O
] PUNCT O
. PUNCT O

We PRON O
particularly ADV O
report VERB O
on ADP O
the DET O
functional ADJ O
significance NOUN O
of ADP O
CB1 PROPN B-AC
receptor NOUN O
interactions NOUN O
with ADP O
the DET O
Wiskott PROPN B-LF
- PUNCT I-LF
Aldrich PROPN I-LF
syndrome PROPN I-LF
protein NOUN I-LF
- PUNCT I-LF
family NOUN I-LF
verprolin NOUN I-LF
- PUNCT I-LF
homologous ADJ I-LF
protein NOUN I-LF
1 NUM I-LF
( PUNCT O
WAVE1)/SCAR1 PROPN B-AC
complex NOUN O
. PUNCT O

Agreement NOUN O
between ADP O
the DET O
PWD PROPN B-AC
and CCONJ O
their PRON O
family NOUN O
carer NOUN O
responses NOUN O
was AUX O
assessed VERB O
using VERB O
Kappa PROPN O
and CCONJ O
Prevalence PROPN B-LF
- PUNCT I-LF
Adjusted PROPN I-LF
Bias PROPN I-LF
- PUNCT I-LF
Adjusted PROPN I-LF
Kappa PROPN I-LF
( PUNCT O
PABAK PROPN B-AC
) PUNCT O
statistics NOUN O
. PUNCT O

The DET O
samples NOUN O
were AUX O
stored VERB O
at ADP O
-20 NUM O
° NOUN O
C NOUN O
and CCONJ O
analyzed VERB O
within ADP O
a DET O
maximum NOUN O
of ADP O
2 NUM O
years NOUN O
for ADP O
high ADJ B-LF
density NOUN I-LF
lipoprotein NOUN I-LF
( PUNCT O
HDL PROPN B-AC
) PUNCT O
cholesterol NOUN O
, PUNCT O
low ADJ O
density NOUN O
density NOUN O
lipoprotein NOUN O
( PUNCT O
LDL PROPN B-AC
) PUNCT O
cholesterol NOUN O
and CCONJ O
total ADJ O
cholesterol NOUN O
( PUNCT O
TC PROPN O
) PUNCT O
, PUNCT O
triacylglycerol NOUN O
( PUNCT O
TG PROPN O
) PUNCT O
and CCONJ O
glycated VERB O
hemaglobin NOUN O
( PUNCT O
HbA1c NOUN O
) PUNCT O
. PUNCT O

Drug NOUN O
- PUNCT O
drug NOUN O
interactions NOUN O
between ADP O
SB-415286 PROPN B-LF
or CCONJ O
LiCl PROPN B-AC
and CCONJ O
TRAIL PROPN B-AC
were AUX O
evaluated VERB O
in ADP O
AGS PROPN O
cells NOUN O
by ADP O
MTT PROPN O
assay NOUN O
. PUNCT O

In ADP O
conjunction NOUN O
with ADP O
serial ADJ B-LF
section NOUN I-LF
light NOUN I-LF
microscopy NOUN I-LF
( PUNCT O
ssLM NOUN B-AC
) PUNCT O
, PUNCT O
we PRON O
use VERB O
computational ADJ B-LF
molecular ADJ I-LF
phenotyping NOUN I-LF
( PUNCT O
CMP PROPN B-AC
, PUNCT O
see VERB O
Marc PROPN O
, PUNCT O
Murry PROPN O
, PUNCT O
and CCONJ O
Basinger PROPN O
[ PUNCT O
54 NUM O
] PUNCT O
and CCONJ O
Marc PROPN O
and CCONJ O
Jones PROPN O
[ PUNCT O
5 NUM O
] PUNCT O
) PUNCT O
. PUNCT O

CS NOUN B-AC
, PUNCT O
complex ADJ B-LF
spike NOUN I-LF
. PUNCT O

As ADP O
in ADP O
the DET O
above ADJ O
analysis NOUN O
of ADP O
gene NOUN O
expression NOUN O
, PUNCT O
we PRON O
measured VERB O
the DET O
percentage NOUN O
of ADP O
CTs NOUN B-AC
in ADP O
three NUM O
concentric ADJ O
nuclear ADJ O
shells NOUN O
of ADP O
equal ADJ O
area NOUN O
( PUNCT O
Figure PROPN O
4A NUM O
) PUNCT O
. PUNCT O
Unexpectedly ADV O
, PUNCT O
all DET O
chromosomes NOUN O
showed VERB O
a DET O
significant ADJ O
enrichment NOUN O
in ADP O
the DET O
central ADJ O
portion NOUN O
of ADP O
the DET O
nucleus NOUN O
when SCONJ O
compared VERB O
with ADP O
the DET O
middle ADJ O
or CCONJ O
outer ADJ O
shells NOUN O
, PUNCT O
regardless ADV O
of ADP O
cell NOUN O
type NOUN O
or CCONJ O
chromosome NOUN O
size NOUN O
/ SYM O
density NOUN O
( PUNCT O
analysis NOUN B-LF
of ADP I-LF
variance NOUN I-LF
( PUNCT O
ANOVA NOUN B-AC
) PUNCT O
, PUNCT O
p NOUN O
< ADP O
0.0001 NUM O
) PUNCT O
( PUNCT O
Figure PROPN O
4B NUM O
; PUNCT O
for ADP O
individual ADJ O
chromosomes NOUN O
, PUNCT O
see VERB O
Figure PROPN O
S4 NUM O
) PUNCT O
. PUNCT O

Controlling VERB O
the DET O
FDR NOUN B-AC
at ADP O
nominal ADJ O
level NOUN O
of ADP O
20 NUM O
% PUNCT O
, PUNCT O
we PRON O
selected VERB O
6 NUM O
associated VERB O
signals NOUN O
: PUNCT O
rs4879801 NOUN O
( PUNCT O
DNAI1 NOUN O
, PUNCT O
Dynein PROPN O
intermediate NOUN O
chain PROPN O
1 NUM O
, PUNCT O
axonemal NOUN O
) PUNCT O
, PUNCT O
rs1203638 NOUN O
( PUNCT O
PRDM2 NOUN B-AC
, PUNCT O
PR PROPN B-LF
domain NOUN I-LF
zinc NOUN I-LF
finger NOUN I-LF
protein NOUN I-LF
2 NUM I-LF
) PUNCT O
, PUNCT O
rs1626645 NOUN O
and CCONJ O
rs894324 NOUN O
( PUNCT O
ASB7 NOUN B-AC
region NOUN O
for ADP O
the DET O
last ADJ O
2 NUM O
, PUNCT O
Ankyrin PROPN B-LF
repeat NOUN I-LF
and CCONJ I-LF
SOCS PROPN I-LF
box NOUN I-LF
protein NOUN I-LF
7 NUM I-LF
) PUNCT O
, PUNCT O
rs4879795 NOUN O
( PUNCT O
DNAI1 NOUN O
) PUNCT O
, PUNCT O
and CCONJ O
rs10508884 NOUN O
( PUNCT O
CXCL12 PROPN O
) PUNCT O
( PUNCT O
Table NOUN O
4 NUM O
, PUNCT O
Fig PROPN O
5A NUM O
) PUNCT O
. PUNCT O
The DET O
value NOUN O
of ADP O
the DET O
genomic ADJ O
control NOUN O
was AUX O
close ADJ O
to ADP O
one NUM O
. PUNCT O

Incremental ADJ B-LF
cost NOUN I-LF
- PUNCT I-LF
effectiveness NOUN I-LF
ratios NOUN I-LF
( PUNCT O
ICERs NOUN B-AC
) PUNCT O
were AUX O
estimated VERB O
to ADP O
compare VERB O
the DET O
2 NUM O
intervention NOUN O
arms NOUN O
to ADP O
the DET O
SOC PROPN B-AC
arm NOUN O
. PUNCT O

During ADP O
our PRON O
ongoing ADJ O
quest NOUN O
for ADP O
physiological ADJ O
functions NOUN O
of ADP O
Smurfs PROPN B-AC
, PUNCT O
we PRON O
found VERB O
abnormal ADJ O
accumulation NOUN O
of ADP O
lipid NOUN O
droplets NOUN O
in ADP O
the DET O
livers NOUN O
of ADP O
9–12 NUM O
- PUNCT O
month NOUN O
- PUNCT O
old ADJ O
Smurf1 PROPN O
knockout NOUN B-LF
( PUNCT O
KO PROPN B-AC
) PUNCT O
mice NOUN O
and CCONJ O
other ADJ O
signs NOUN O
that PRON O
phenocopy VERB O
NAFLD PROPN B-AC
in ADP O
human ADJ O
patients NOUN O
. PUNCT O

Finally ADV O
, PUNCT O
the DET O
cells NOUN O
were AUX O
cultured VERB O
for ADP O
11 NUM O
days NOUN O
in ADP O
various ADJ O
hepatocyte NOUN O
culture NOUN O
medium NOUN O
with ADP O
20 NUM O
ng NOUN O
/ SYM O
ml NOUN O
oncostatin NOUN B-LF
M PROPN I-LF
( PUNCT O
OsM PROPN B-AC
) PUNCT O
. PUNCT O

At ADP O
baseline NOUN O
, PUNCT O
1.5 NUM O
% NOUN O
had VERB O
an DET O
estimated VERB B-LF
glomerular ADJ I-LF
filtration NOUN I-LF
rate NOUN I-LF
( PUNCT O
eGFR NOUN B-AC
) PUNCT O
< ADP O
70 NUM O
mL NOUN O
/ SYM O
min/1.73m2 NUM O
. PUNCT O

A NOUN B-AC
/ SYM B-AC
P NOUN B-AC
, PUNCT O
anterior ADJ B-LF
– PUNCT I-LF
posterior NOUN I-LF
; PUNCT O
BE PROPN B-AC
, PUNCT O
Boundary NOUN B-LF
enhancer NOUN I-LF
; PUNCT O
D NOUN B-AC
/ SYM B-AC
V NOUN B-AC
, PUNCT O
dorso NOUN B-LF
– PUNCT I-LF
ventral NOUN I-LF
; PUNCT O
Dpp PROPN B-AC
, PUNCT O
Decapentaplegic NOUN B-LF
; PUNCT O
Ds PROPN B-AC
, PUNCT O
Dachsous NOUN B-LF
; PUNCT O
FF PROPN B-AC
, PUNCT O
feed NOUN B-LF
- PUNCT I-LF
forward NOUN I-LF
; PUNCT O
Fj PROPN B-AC
, PUNCT O
Four NUM B-LF
- PUNCT I-LF
Jointed PROPN I-LF
; PUNCT O
Ft PROPN B-AC
, PUNCT O
Fat PROPN B-LF
; PUNCT O
PCP PROPN O
, PUNCT O
planar NOUN O
cell NOUN O
polarity NOUN O
; PUNCT O
QE PROPN B-AC
, PUNCT O
Quadrant NOUN B-LF
enhancer NOUN I-LF
; PUNCT O
Sd PROPN O
, PUNCT O
Scalloped VERB O
; PUNCT O
Vg PROPN B-AC
, PUNCT O
Vestigial NOUN B-LF
; PUNCT O
Wg PROPN B-AC
, PUNCT O
Wingless PROPN B-LF
; PUNCT O
Wts PROPN B-AC
, PUNCT O
Warts NOUN B-LF
; PUNCT O
Yki PROPN B-AC
, PUNCT O
Yorkie PROPN B-LF
. PUNCT O

All DET O
participants NOUN O
with ADP O
AF PROPN B-AC
qualified VERB O
for ADP O
anticoagulation NOUN O
and CCONJ O
were AUX O
more ADV O
likely ADJ O
to PART O
be AUX O
male ADJ O
( PUNCT O
57.7 NUM O
% PUNCT O
) PUNCT O
; PUNCT O
be AUX O
older ADJ O
; PUNCT O
have VERB O
an DET O
increased ADJ O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT O
BMI NOUN B-AC
) PUNCT O
; PUNCT O
and CCONJ O
have VERB O
a DET O
CHA2DS2 PROPN B-AC
- PUNCT B-AC
VASc PROPN B-AC
( PUNCT O
Congestive ADJ B-LF
heart NOUN I-LF
failure NOUN I-LF
, PUNCT I-LF
Hypertension NOUN I-LF
, PUNCT I-LF
Age NOUN I-LF
≥ ADP I-LF
75 NUM I-LF
years NOUN I-LF
, PUNCT I-LF
Diabetes NOUN I-LF
, PUNCT I-LF
previous ADJ I-LF
Stroke NOUN I-LF
, PUNCT I-LF
Vascular ADJ I-LF
disease NOUN I-LF
, PUNCT I-LF
Age NOUN I-LF
65–74 NUM I-LF
years NOUN I-LF
, PUNCT I-LF
Sex NOUN I-LF
category NOUN I-LF
) PUNCT O
score NOUN O
≥ ADP O
3 NUM O
. PUNCT O

We PRON O
identified VERB O
a DET O
brown ADJ O
adipose ADJ O
tissue NOUN O
– PUNCT O
enriched VERB O
lncRNA NOUN B-AC
, PUNCT O
lncBATE10 PROPN O
, PUNCT O
that PRON O
was AUX O
governed VERB O
by ADP O
the DET O
cAMP NOUN O
- PUNCT O
cAMP NOUN B-LF
response NOUN I-LF
element NOUN I-LF
- PUNCT I-LF
binding VERB I-LF
protein NOUN I-LF
( PUNCT O
Creb PROPN B-AC
) PUNCT O
axis NOUN O
and CCONJ O
required VERB O
for ADP O
a DET O
full ADJ O
brown ADJ O
fat NOUN O
differentiation NOUN O
and CCONJ O
white ADJ O
fat NOUN O
browning NOUN O
program NOUN O
. PUNCT O

Other ADJ O
secondary ADJ O
outcomes NOUN O
were AUX O
changes NOUN O
in ADP O
postprandial ADJ O
endothelial ADJ O
function NOUN O
( PUNCT O
FDR PROPN B-AC
, PUNCT O
peak ADJ O
FBF PROPN B-AC
, PUNCT O
and CCONJ O
duration NOUN O
of ADP O
RH NOUN B-AC
) PUNCT O
, PUNCT O
nutritional ADJ O
intake NOUN O
, PUNCT O
bodyweight NOUN O
, PUNCT O
body NOUN O
fat NOUN O
, PUNCT O
plasma NOUN O
levels NOUN O
of ADP O
glucose NOUN O
and CCONJ O
insulin NOUN O
in ADP O
the DET O
fasting ADJ O
and CCONJ O
postprandial ADJ O
states NOUN O
, PUNCT O
HbA1c NOUN B-AC
, PUNCT O
glycoalbumin NOUN O
, PUNCT O
triglyceride NOUN O
, PUNCT O
total NOUN O
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
( PUNCT O
HDL)- PROPN B-AC
and CCONJ O
low ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
( PUNCT O
LDL)-cholesterol NOUN B-AC
, PUNCT O
adiponectin NOUN O
, PUNCT O
ADMA PROPN B-AC
, PUNCT O
tissue NOUN B-LF
plasminogen NOUN I-LF
activator NOUN I-LF
inhibitor-1 NOUN I-LF
( PUNCT O
tPAI-1 PROPN B-AC
) PUNCT O
, PUNCT O
high ADJ O
- PUNCT O
sensitivity NOUN O
C NOUN O
- PUNCT O
reactive ADJ O
protein NOUN O
( PUNCT O
hs NOUN O
- PUNCT O
CRP PROPN O
) PUNCT O
, PUNCT O
and CCONJ O
urine NOUN O
levels NOUN O
of ADP O
8 NUM O
- PUNCT O
isoprostane NOUN O
. PUNCT O

BRT PROPN B-AC
, PUNCT O
boosted VERB B-LF
regression NOUN I-LF
tree NOUN I-LF
; PUNCT O
Chla PROPN O
, PUNCT O
chlorophyll NOUN O
- PUNCT O
a DET O
concentration NOUN O
; PUNCT O
Dist PROPN O
coast NOUN O
, PUNCT O
distance NOUN O
to ADP O
nearest ADJ O
coast NOUN O
; PUNCT O
Dist PROPN O
CoralTri PROPN O
, PUNCT O
distance NOUN O
to ADP O
the DET O
Coral PROPN O
Triangle PROPN O
; PUNCT O
Dist PROPN O
market NOUN O
, PUNCT O
distance NOUN O
to ADP O
nearest ADJ O
market NOUN O
; PUNCT O
Dist PROPN O
seamount NOUN O
, PUNCT O
distance NOUN O
to ADP O
nearest ADJ O
seamount NOUN O
with ADP O
a DET O
summit NOUN O
depth NOUN O
of ADP O
< ADP O
1,500 NUM O
m NOUN O
; PUNCT O
SST PROPN B-AC
, PUNCT O
sea NOUN B-LF
surface NOUN I-LF
temperature NOUN I-LF
. PUNCT O

RTP PROPN B-AC
, PUNCT O
Arabidopsis PROPN O
thaliana NOUN O
ribulose NOUN O
bisphosphate NOUN O
carboxylase NOUN O
small ADJ O
subunit NOUN O
transit NOUN O
peptide NOUN O
; PUNCT O
SaSSy PROPN B-AC
, PUNCT O
Santalum PROPN O
album NOUN O
santalene NOUN B-LF
synthase NOUN I-LF
; PUNCT O
FPS PROPN B-AC
, PUNCT O
A. NOUN O
thaliana NOUN O
farnesyl NOUN B-LF
diphosphate NOUN I-LF
synthase NOUN I-LF
; PUNCT O
HMGR PROPN B-AC
, PUNCT O
A. NOUN O
thaliana NOUN O
3 NUM B-LF
- PUNCT I-LF
hydroxy-3 NOUN I-LF
- PUNCT I-LF
methylglutaryl NOUN I-LF
- PUNCT I-LF
CoA NOUN I-LF
reductase NOUN I-LF
; PUNCT O
tHMGR PROPN B-AC
, PUNCT O
A. NOUN O
thaliana NOUN O
truncated VERB O
HMGR PROPN B-AC
. PUNCT O
SaCYP76F39v1 PROPN O
, PUNCT O
Santalum PROPN O
album NOUN O
santalene NOUN O
/ SYM O
bergamotene NOUN O
oxidase(CYP76F39v1 NOUN O
) PUNCT O
. PUNCT O

The DET O
presented VERB O
adjusted VERB O
values NOUN O
at ADP O
3 NUM O
, PUNCT O
6 NUM O
, PUNCT O
9 NUM O
and CCONJ O
12 NUM O
months NOUN O
and CCONJ O
their PRON O
confidence NOUN B-LF
intervals NOUN I-LF
( PUNCT O
CIs NOUN B-AC
) PUNCT O
are AUX O
similar ADJ O
to ADP O
the DET O
unadjusted ADJ O
values NOUN O
( PUNCT O
not PART O
presented VERB O
) PUNCT O
. PUNCT O

Underlying VERB O
data NOUN O
can AUX O
be AUX O
found VERB O
in ADP O
S1 PROPN O
Data PROPN O
. PUNCT O
exorh PROPN B-AC
, PUNCT O
exorhodopsin NOUN B-LF
; PUNCT O
hpf NOUN B-AC
, PUNCT O
hours NOUN B-LF
post NOUN I-LF
fertilization NOUN I-LF
; PUNCT O
post NOUN O
, PUNCT O
posterior NOUN O
; PUNCT O
PhR NOUN B-AC
, PUNCT O
photoreceptor NOUN B-LF
; PUNCT O
PT NOUN B-AC
, PUNCT O
parietopsin NOUN B-LF
. PUNCT O

Urine NOUN O
, PUNCT O
blood NOUN O
, PUNCT O
and CCONJ O
renal ADJ O
tissues NOUN O
were AUX O
collected VERB O
at ADP O
the DET O
end NOUN O
of ADP O
the DET O
experiment NOUN O
for ADP O
assessment NOUN O
of ADP O
kidney NOUN O
function NOUN O
tests NOUN O
( PUNCT O
serum NOUN O
creatinine NOUN O
and CCONJ O
urea NOUN O
) PUNCT O
, PUNCT O
urinary ADJ O
( PUNCT O
8 NUM B-LF
- NOUN I-LF
hydroxydeoxyguanosine NOUN I-LF
( PUNCT O
8 NUM B-AC
- NOUN B-AC
OHdG NOUN B-AC
) PUNCT O
, PUNCT O
calcium NOUN O
and CCONJ O
oxalate NOUN O
) PUNCT O
, PUNCT O
inflammatory ADJ O
and CCONJ O
oxdative ADJ O
stress NOUN O
biomarkers NOUN O
( PUNCT O
transforming VERB B-LF
growth NOUN I-LF
factor NOUN I-LF
beta NOUN I-LF
( PUNCT O
TGF PROPN B-AC
- NOUN B-AC
β PROPN B-AC
) PUNCT O
, PUNCT O
osteopontin NOUN B-LF
( PUNCT O
OPN PROPN B-AC
) PUNCT O
and CCONJ O
ratio NOUN O
of ADP O
reduced VERB O
glutathione NOUN O
to ADP O
oxidized VERB O
glutathione NOUN O
( PUNCT O
GSH PROPN B-AC
/ SYM B-AC
GSSG PROPN B-AC
) PUNCT O
) PUNCT O
in ADP O
renal ADJ O
tissue NOUN O
. PUNCT O

1H NOUN O
, PUNCT O
high ADJ O
; PUNCT O
L NOUN O
, PUNCT O
low ADJ O
; PUNCT O
NA PROPN O
, PUNCT O
not PART O
applicable ADJ O
; PUNCT O
RCT PROPN B-AC
, PUNCT O
randomized ADJ B-LF
controlled ADJ I-LF
trial NOUN I-LF
; PUNCT O
ROB PROPN B-AC
, PUNCT O
risk NOUN B-LF
of ADP I-LF
bias NOUN I-LF
; PUNCT O
U NOUN O
, PUNCT O
unclear ADJ O
. PUNCT O

The DET O
per ADP O
- PUNCT O
capita NOUN O
– PUNCT O
demand NOUN O
( PUNCT O
PCD NOUN O
) PUNCT O
expressed VERB O
in ADP O
liters NOUN B-LF
per ADP I-LF
capita NOUN I-LF
per ADP I-LF
day NOUN I-LF
( PUNCT O
lpcd NOUN B-AC
) PUNCT O
is AUX O
the DET O
coefficient NOUN O
used VERB O
for ADP O
modeling VERB O
water NOUN O
demands NOUN O
by ADP O
population NOUN O
dependent ADJ O
sectors NOUN O
. PUNCT O

The DET O
renin NOUN B-LF
- PUNCT I-LF
angiotensin NOUN I-LF
aldosterone NOUN I-LF
hormone NOUN I-LF
system NOUN I-LF
’s PART O
( PUNCT O
RAAS PROPN B-AC
) PUNCT O
main ADJ O
function NOUN O
is AUX O
to PART O
maintain VERB O
the DET O
homeostasis NOUN O
of ADP O
arterial ADJ O
pressure NOUN O
and CCONJ O
of ADP O
extracellular ADJ O
fluids NOUN O
[ PUNCT O
4 NUM O
] PUNCT O
. PUNCT O

ARV PROPN O
= VERB O
antiretroviral ADJ O
; PUNCT O
HTC PROPN B-AC
= VERB O
HIV PROPN B-LF
testing NOUN I-LF
and CCONJ I-LF
counseling NOUN I-LF
; PUNCT O
PMTCT PROPN B-AC
= VERB O
prevention NOUN B-LF
of ADP I-LF
mother NOUN I-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
child NOUN I-LF
transmission NOUN I-LF
; PUNCT O
VMMC PROPN B-AC
= VERB O
voluntary ADJ B-LF
medical ADJ I-LF
male ADJ I-LF
circumcision NOUN I-LF
. PUNCT O

G PROPN B-LF
protein NOUN I-LF
– PUNCT I-LF
coupled VERB I-LF
receptors NOUN I-LF
( PUNCT O
GPCRs PROPN B-AC
) PUNCT O
exist VERB O
in ADP O
multiple ADJ O
dynamic ADJ O
states NOUN O
( PUNCT O
e.g. X O
, PUNCT O
ligand NOUN O
- PUNCT O
bound VERB O
, PUNCT O
inactive ADJ O
, PUNCT O
G PROPN B-AC
protein NOUN B-AC
– PUNCT O
coupled VERB O
) PUNCT O
that PRON O
influence VERB O
G PROPN B-AC
protein NOUN B-AC
activation NOUN O
and CCONJ O
ultimately ADV O
response NOUN O
generation NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
AMR PROPN B-AC
, PUNCT O
antimicrobial ADJ B-LF
resistance NOUN I-LF
. PUNCT O

This DET O
study NOUN O
is AUX O
reported VERB O
per ADP O
the DET O
Strengthening VERB B-LF
the DET I-LF
Reporting PROPN I-LF
of ADP I-LF
Observational PROPN I-LF
Studies PROPN I-LF
in ADP I-LF
Epidemiology PROPN I-LF
( PUNCT O
STROBE PROPN B-AC
) PUNCT O
guidelines NOUN O
( PUNCT O
S4 NUM O
Appendix NOUN O
) PUNCT O
. PUNCT O

ACR PROPN B-AC
, PUNCT O
albumin NOUN B-LF
: PUNCT I-LF
creatinine NOUN I-LF
ratio NOUN I-LF
; PUNCT O
BP PROPN B-AC
, PUNCT O
blood NOUN B-LF
pressure NOUN I-LF
; PUNCT O
CHD PROPN B-AC
, PUNCT O
coronary ADJ B-LF
heart NOUN I-LF
disease NOUN I-LF
; PUNCT O
CKD PROPN B-AC
, PUNCT O
chronic ADJ B-LF
kidney NOUN I-LF
disease NOUN I-LF
; PUNCT O
eGFR NOUN B-AC
, PUNCT O
estimated VERB B-LF
glomerular ADJ I-LF
filtration NOUN I-LF
rate NOUN I-LF
; PUNCT O
ESRD NOUN B-AC
, PUNCT O
end NOUN B-LF
- PUNCT I-LF
stage NOUN I-LF
renal ADJ I-LF
disease NOUN I-LF
; PUNCT O
HbA1c NOUN B-AC
, PUNCT O
hemoglobin NOUN B-LF
A1c NOUN I-LF
; PUNCT O
HDL PROPN B-AC
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
; PUNCT O
JADE PROPN B-AC
, PUNCT O
Joint PROPN B-LF
Asia PROPN I-LF
Diabetes PROPN I-LF
Evaluation PROPN I-LF
; PUNCT O
JADE PROPN B-AC
- PUNCT B-AC
P PROPN B-AC
, PUNCT O
JADE PROPN B-LF
- PUNCT I-LF
Personalized VERB I-LF
; PUNCT O
LDL PROPN B-AC
, PUNCT O
low ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
; PUNCT O
MI PROPN O
, PUNCT O
myocardial ADJ O
infarction NOUN O
; PUNCT O
PVD PROPN B-AC
, PUNCT O
peripheral ADJ B-LF
vascular ADJ I-LF
disease NOUN I-LF
; PUNCT O
RASi PROPN B-AC
, PUNCT O
renin NOUN B-LF
- PUNCT I-LF
angiotensin NOUN I-LF
system NOUN I-LF
inhibitors NOUN I-LF
. PUNCT O

Coronavirus NOUN B-LF
disease NOUN I-LF
2019 NUM I-LF
( PUNCT O
COVID-19 NOUN B-AC
) PUNCT O
, PUNCT O
caused VERB O
by ADP O
severe ADJ B-LF
acute ADJ I-LF
respiratory ADJ I-LF
syndrome NOUN I-LF
coronavirus-2 NOUN I-LF
( PUNCT O
SARS PROPN B-AC
- PUNCT B-AC
CoV-2 PROPN B-AC
) PUNCT O
, PUNCT O
has AUX O
caused VERB O
a DET O
pandemic NOUN O
with ADP O
millions NOUN O
of ADP O
cases NOUN O
and CCONJ O
deaths NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

ChIP PROPN B-AC
- PUNCT B-AC
seq NOUN B-AC
, PUNCT O
chromatin NOUN B-LF
immunoprecipitation NOUN I-LF
sequencing NOUN I-LF
; PUNCT O
FOXO1 PROPN O
, PUNCT O
Forkhead PROPN O
Box PROPN O
O1 PROPN O
; PUNCT O
Fr PROPN B-AC
. PUNCT B-AC
C PROPN B-AC
, PUNCT O
proliferating VERB B-LF
B NOUN I-LF
cell NOUN I-LF
progenitor NOUN I-LF
; PUNCT O
Fr PROPN B-AC
. PUNCT B-AC
D PROPN B-AC
, PUNCT O
differentiating VERB B-LF
B NOUN I-LF
cell NOUN I-LF
progenitor NOUN I-LF
; PUNCT O
OR PROPN O
, PUNCT O
odds NOUN O
ratio NOUN O
; PUNCT O
scRNA NOUN B-AC
- PUNCT B-AC
seq NOUN B-AC
, PUNCT O
single ADJ B-LF
cell NOUN I-LF
RNA NOUN I-LF
sequencing NOUN I-LF
; PUNCT O
4 NUM B-AC
- PUNCT B-AC
OHT NOUN B-AC
, PUNCT O
4 NUM B-LF
- PUNCT I-LF
hydroxy NOUN I-LF
- PUNCT I-LF
tamoxifen NOUN I-LF
. PUNCT O

AURAH2 PROPN B-AC
, PUNCT O
The DET B-LF
Attitudes PROPN I-LF
to ADP I-LF
and CCONJ I-LF
Understanding PROPN I-LF
of ADP I-LF
Risk PROPN I-LF
of ADP I-LF
Acquisition PROPN I-LF
of ADP I-LF
HIV PROPN I-LF
2 NUM I-LF
; PUNCT O
CI PROPN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
GBMSM PROPN B-AC
, PUNCT O
gay ADJ B-LF
, PUNCT I-LF
bisexual ADJ I-LF
, PUNCT I-LF
and CCONJ I-LF
other ADJ I-LF
men NOUN I-LF
who PRON I-LF
have VERB I-LF
sex NOUN I-LF
with ADP I-LF
men NOUN I-LF
; PUNCT O
IR PROPN B-AC
, PUNCT O
incidence NOUN B-LF
rate NOUN I-LF
; PUNCT O
PY PROPN B-AC
, PUNCT O
person NOUN B-LF
- PUNCT I-LF
years NOUN I-LF
. PUNCT O

Briefly ADV O
, PUNCT O
DR1+DO PROPN B-AC
- PUNCT O
WT PROPN B-AC
and CCONJ O
DR1+DO PROPN B-AC
- PUNCT O
KO PROPN B-AC
mice NOUN O
received VERB O
a DET O
primary ADJ O
subcutaneous ADJ O
tail NOUN O
injection NOUN O
of ADP O
bovine ADJ B-LF
type NOUN I-LF
II NUM I-LF
collagen NOUN I-LF
( PUNCT O
bCII NOUN B-AC
) PUNCT O
protein NOUN O
followed VERB O
by ADP O
a DET O
second ADJ O
subcutaneous ADJ O
tail NOUN O
immunization NOUN O
21 NUM O
days NOUN O
later ADV O
( PUNCT O
Materials NOUN O
and CCONJ O
methods NOUN O
) PUNCT O
. PUNCT O

FITC PROPN O
, PUNCT O
fluorescein NOUN O
isothiocyanate NOUN O
; PUNCT O
G6PDH PROPN O
, PUNCT O
glucose-6 NUM O
- PUNCT O
phosphate NOUN O
dehydrogenase NOUN O
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
. PUNCT O

The DET O
STAT3 PROPN B-AC
- PUNCT B-AC
LPX PROPN B-AC
had VERB O
an DET O
average ADJ O
diameter NOUN O
of ADP O
3.50±0.29 NUM O
μm NOUN O
with ADP O
an DET O
average ADJ O
concentration NOUN O
of ADP O
2×109 NUM O
microbubbles NOUN B-LF
/ SYM O
mL NOUN O
and CCONJ O
a DET O
loading NOUN O
capacity NOUN O
of ADP O
50 NUM O
μg NOUN O
of ADP O
STAT3 PROPN B-AC
decoy NOUN O
per ADP O
1×109 NUM O
microbubbles NOUN B-LF
( PUNCT O
5 NUM O
- PUNCT O
fold ADJ O
higher ADJ O
than ADP O
STAT3 PROPN B-AC
- PUNCT B-AC
MB NOUN B-AC
) PUNCT O
. PUNCT O

Using VERB O
liquid NOUN B-LF
chromatography NOUN I-LF
high ADJ I-LF
- PUNCT I-LF
resolution NOUN I-LF
mass NOUN I-LF
spectrometry NOUN I-LF
( PUNCT O
LC NOUN B-AC
- PUNCT B-AC
HR NOUN B-AC
- PUNCT B-AC
MS PROPN B-AC
/ SYM B-AC
MS PROPN B-AC
) PUNCT O
analysis NOUN O
, PUNCT O
we PRON O
discovered VERB O
1,360 NUM O
differentially ADV O
expressed VERB O
proteins NOUN O
in ADP O
CLL PROPN B-AC
patients NOUN O
compared VERB O
to PART O
healthy ADJ O
donors NOUN O
, PUNCT O
several ADJ O
of ADP O
which PRON O
had AUX O
been AUX O
previously ADV O
reported VERB O
to PART O
be AUX O
associated VERB O
with ADP O
cancer NOUN O
, PUNCT O
yet CCONJ O
four NUM O
of ADP O
which PRON O
were AUX O
identified VERB O
as ADP O
being AUX O
associated VERB O
with ADP O
any DET O
cancer NOUN O
, PUNCT O
including VERB O
CLL PROPN B-AC
, PUNCT O
for ADP O
the DET O
first ADJ O
time NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
IRE1 PROPN B-AC
, PUNCT O
inositol NOUN B-LF
- PUNCT I-LF
requiring VERB I-LF
enzyme NOUN I-LF
1 NUM I-LF
; PUNCT O
eIF2 PROPN B-AC
, PUNCT O
eukaryotic ADJ B-LF
initiation NOUN I-LF
factor NOUN I-LF
2 NUM I-LF
; PUNCT O
CHOP PROPN B-AC
, PUNCT O
C NOUN B-LF
/ SYM I-LF
EBP NOUN I-LF
- PUNCT I-LF
homologous ADJ I-LF
protein NOUN I-LF
. PUNCT O

CI PROPN O
, PUNCT O
confidence NOUN O
interval NOUN O
; PUNCT O
HR PROPN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
. PUNCT O

HS PROPN B-AC
, PUNCT O
high ADJ B-LF
salt NOUN I-LF
; PUNCT O
LPS PROPN B-AC
, PUNCT O
lipopolysaccharide NOUN B-LF
; PUNCT O
MΦ PROPN B-AC
, PUNCT O
monocyte NOUN B-LF
/ SYM I-LF
macrophage NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
cell NOUN I-LF
; PUNCT O
[ X O
Na+]i X O
, PUNCT O
intracellular ADJ O
Na+ NOUN O
in ADP O
situ NOUN O
; PUNCT O
NS PROPN B-AC
, PUNCT O
normal ADJ B-LF
salt NOUN I-LF
. PUNCT O

The DET O
hypocholesterolaemic ADJ O
effect NOUN O
in ADP O
the DET O
liver NOUN O
was AUX O
associated VERB O
with ADP O
decreased VERB O
relative ADJ O
expression NOUN O
of ADP O
3 NUM O
- PUNCT O
hydroxy-3 NOUN O
- PUNCT O
methyl NOUN O
- PUNCT O
glutaryl NOUN O
- PUNCT O
coenzyme NOUN O
A NOUN O
reductase NOUN O
( PUNCT O
HMGCR PROPN O
, PUNCT O
a DET O
key ADJ O
enzyme NOUN O
involved VERB O
in ADP O
cholesterol NOUN O
synthesis NOUN O
) PUNCT O
and CCONJ O
stearoyl NOUN B-LF
- PUNCT I-LF
CoA PROPN I-LF
desaturase NOUN I-LF
1(SCD-1 PROPN B-AC
, PUNCT O
a DET O
key ADJ O
lipogenic ADJ O
enzyme NOUN O
) PUNCT O
( PUNCT O
Figs NOUN O
2 NUM O
and CCONJ O
3 NUM O
) PUNCT O
. PUNCT O

Data NOUN O
are AUX O
reported VERB O
as ADP O
median ADJ O
and CCONJ O
interquartile ADJ B-LF
range NOUN I-LF
( PUNCT O
IQR PROPN B-AC
) PUNCT O
or CCONJ O
mean NOUN O
± SYM O
standard ADJ O
deviation NOUN O
for ADP O
continuous ADJ O
variables NOUN O
and CCONJ O
as ADP O
proportions NOUN O
for ADP O
categorical ADJ O
variables NOUN O
. PUNCT O

This DET O
study NOUN O
examines VERB O
the DET O
relationship NOUN O
between ADP O
IgE PROPN B-AC
responses NOUN O
to ADP O
multiple ADJ O
allergen NOUN O
components NOUN O
in ADP O
component NOUN B-LF
- PUNCT I-LF
resolved VERB I-LF
diagnostics NOUN I-LF
( PUNCT O
CRD PROPN B-AC
) PUNCT O
and CCONJ O
their PRON O
associations NOUN O
with ADP O
asthma NOUN O
. PUNCT O

All DET O
media NOUN O
were AUX O
autoclaved VERB O
at ADP O
121 NUM O
° NOUN O
C NOUN O
for ADP O
21 NUM O
min NOUN O
, PUNCT O
and CCONJ O
once SCONJ O
the DET O
temperature NOUN O
of ADP O
the DET O
media NOUN O
was AUX O
lower ADJ O
than ADP O
50 NUM O
° NOUN O
C NOUN O
, PUNCT O
glutamine(Gln NOUN B-LF
) PUNCT O
, PUNCT O
acid NOUN B-LF
hydrolysed VERB I-LF
casein(CH NOUN I-LF
) PUNCT O
, PUNCT O
inositol NOUN O
, PUNCT O
kanamycin(Kan NOUN B-LF
) PUNCT O
, PUNCT O
gentamicin(Gen NOUN B-LF
) PUNCT O
, PUNCT O
cefotaxime(Cef NOUN B-LF
) PUNCT O
, PUNCT O
hygromycin NOUN B-LF
B(Hyg PROPN I-LF
) PUNCT O
, PUNCT O
Acetosyringone NOUN B-LF
( PUNCT O
As PROPN B-AC
) PUNCT O
, PUNCT O
2 NUM O
4 NUM O
- PUNCT O
D NOUN O
and CCONJ O
KT NOUN B-AC
were AUX O
added VERB O
after ADP O
filtering VERB O
. PUNCT O

The DET O
objectives NOUN O
of ADP O
this DET O
study NOUN O
were AUX O
to PART O
( PUNCT O
1 X O
) PUNCT O
simulate VERB O
the DET O
transmission NOUN O
dynamics NOUN O
of ADP O
SARS PROPN B-AC
- PUNCT B-AC
CoV-2 PROPN B-AC
using VERB O
publicly ADV O
available ADJ O
surveillance NOUN O
data NOUN O
and CCONJ O
( PUNCT O
2 X O
) PUNCT O
infer VERB O
estimates NOUN O
of ADP O
SARS PROPN B-AC
- PUNCT B-AC
CoV-2 PROPN B-AC
mortality NOUN O
adjusted VERB O
for ADP O
biases NOUN O
and CCONJ O
examine VERB O
the DET O
CFR PROPN B-AC
, PUNCT O
the DET O
symptomatic ADJ B-LF
case NOUN I-LF
– PUNCT I-LF
fatality NOUN I-LF
ratio NOUN I-LF
( PUNCT O
sCFR PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
the DET O
infection NOUN B-LF
– PUNCT I-LF
fatality NOUN I-LF
ratio NOUN I-LF
( PUNCT O
IFR PROPN B-AC
) PUNCT O
in ADP O
different ADJ O
geographic ADJ O
locations NOUN O
. PUNCT O

Statistical ADJ O
significance NOUN O
was AUX O
performed VERB O
by ADP O
chi NOUN O
- PUNCT O
square ADJ O
test NOUN O
. PUNCT O
( PUNCT O
F NOUN O
) PUNCT O
A NOUN O
proposed VERB O
model NOUN O
for ADP O
P. PROPN O
gingivalis PROPN O
- PUNCT O
induced VERB O
aggressive ADJ O
progression NOUN O
of ADP O
ESCC PROPN B-AC
. PUNCT O
ESCC PROPN B-AC
, PUNCT O
esophageal ADJ B-LF
squamous ADJ I-LF
cell NOUN I-LF
carcinoma NOUN I-LF
; PUNCT O
GARP PROPN B-AC
, PUNCT O
glycoprotein NOUN B-LF
A NOUN I-LF
repetitions NOUN I-LF
predominant ADJ I-LF
; PUNCT O
IHC PROPN B-AC
, PUNCT O
immunohistochemistry NOUN B-LF
; PUNCT O
LAP PROPN O
, PUNCT O
latency NOUN O
- PUNCT O
associated VERB O
protein NOUN O
; PUNCT O
Lats PROPN B-AC
, PUNCT O
large ADJ B-LF
tumor NOUN I-LF
suppressor NOUN I-LF
homolog NOUN I-LF
; PUNCT O
Merlin PROPN B-AC
, PUNCT O
moesin NOUN B-LF
- PUNCT I-LF
ezrin NOUN I-LF
- PUNCT I-LF
radixin NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
protein NOUN I-LF
; PUNCT O
pS PROPN O
, PUNCT O
phosphorylated VERB O
serine NOUN O
/ SYM O
threonine NOUN O
; PUNCT O
pSmad PROPN B-AC
, PUNCT O
phosphorylated VERB B-LF
Smad PROPN I-LF
; PUNCT O
SARA PROPN O
, PUNCT O
Smad PROPN O
anchor NOUN O
receptor NOUN O
activation NOUN O
; PUNCT O
Smad PROPN O
, PUNCT O
Drosophila PROPN O
mothers NOUN O
against ADP O
decapentaplegic ADJ O
homolog NOUN O
; PUNCT O
TAZ PROPN B-AC
, PUNCT O
Transcriptional ADJ B-LF
coactivator NOUN I-LF
with ADP I-LF
PDZ NOUN I-LF
- PUNCT I-LF
binding VERB I-LF
motif NOUN I-LF
; PUNCT O
TEAD1 PROPN B-AC
, PUNCT O
TEA PROPN B-LF
domain NOUN I-LF
transcription NOUN I-LF
factor1 NOUN I-LF
; PUNCT O
TGFβ PROPN B-AC
, PUNCT O
transforming VERB B-LF
growth NOUN I-LF
factor NOUN I-LF
- PUNCT I-LF
β NOUN I-LF
; PUNCT O
TNM PROPN B-AC
, PUNCT O
tumor NOUN B-LF
- PUNCT I-LF
node NOUN I-LF
metastasis NOUN I-LF
; PUNCT O
YAP PROPN B-AC
, PUNCT O
Yes PROPN B-LF
- PUNCT I-LF
associated VERB I-LF
protein NOUN I-LF
. PUNCT O

We PRON O
defined VERB O
A PROPN O
Body PROPN B-LF
Shape PROPN I-LF
Index PROPN I-LF
( PUNCT O
ABSI PROPN B-AC
) PUNCT O
according VERB O
to ADP O
the DET O
definition NOUN O
by ADP O
Krakauer PROPN O
N.Y. PROPN O
et NOUN O
al NOUN O
. NOUN O
[ X O
8 NUM O
] X O
based VERB O
on ADP O
WC PROPN B-AC
adjusted VERB O
for ADP O
height NOUN O
and CCONJ O
weight NOUN O
: PUNCT O
ABSI PROPN B-AC
= SYM O
WCBMI2/3Height1/2 NUM O

Residual ADJ B-LF
dipolar ADJ I-LF
couplings NOUN I-LF
( PUNCT O
RDCs PROPN B-AC
) PUNCT O
[ X O
33 NUM O
] PUNCT O
report VERB O
on ADP O
time NOUN O
and CCONJ O
ensemble NOUN O
- PUNCT O
averaged VERB O
conformations NOUN O
[ X O
34 NUM O
] PUNCT O
and CCONJ O
can AUX O
be AUX O
used VERB O
to PART O
understand VERB O
both CCONJ O
the DET O
structure NOUN O
and CCONJ O
dynamics NOUN O
of ADP O
disordered ADJ O
proteins NOUN O
[ X O
35 NUM O
] PUNCT O
. PUNCT O

Three NUM O
- PUNCT O
year NOUN O
cumulative ADJ O
mortality NOUN O
risk NOUN O
was AUX O
3.2 NUM O
% NOUN O
( PUNCT O
174/5,422 NUM O
) PUNCT O
in ADP O
the DET O
intervention NOUN O
arm NOUN O
and CCONJ O
4.1 NUM O
% NOUN O
( PUNCT O
225/5,426 NUM O
) PUNCT O
in ADP O
the DET O
control NOUN O
arm NOUN O
, PUNCT O
corresponding VERB O
to PART O
a DET O
21 NUM O
% NOUN O
reduction NOUN O
in ADP O
3 NUM O
- PUNCT O
year NOUN O
mortality NOUN O
in ADP O
communities NOUN O
that PRON O
received VERB O
the DET O
SEARCH PROPN B-AC
intervention NOUN O
( PUNCT O
aRR NOUN B-AC
0.79 NUM O
, PUNCT O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
( PUNCT O
CI NOUN B-AC
) PUNCT O
0.64 NUM O
to PART O
0.97 NUM O
, PUNCT O
p NOUN O
= SYM O
0.028 NUM O
) PUNCT O
( PUNCT O
Figs NOUN O
2 NUM O
and CCONJ O
3 NUM O
, PUNCT O
Table NOUN O
D NOUN O
in ADP O
S1 NOUN O
Tables NOUN O
) PUNCT O
. PUNCT O

We PRON O
used VERB O
interrupted VERB B-LF
time NOUN I-LF
series NOUN I-LF
( PUNCT O
ITS PROPN B-AC
) PUNCT O
analysis NOUN O
to PART O
examine VERB O
trends NOUN O
in ADP O
annual ADJ O
LARC ADJ B-AC
and CCONJ O
non ADJ B-LF
- ADJ I-LF
LARC ADJ I-LF
hormonal ADJ I-LF
contraception NOUN I-LF
( PUNCT O
NLHC PROPN B-AC
) PUNCT O
uptake NOUN O
and CCONJ O
abortion NOUN O
rates NOUN O
, PUNCT O
stratified VERB O
by ADP O
age NOUN O
and CCONJ O
deprivation NOUN O
groups NOUN O
, PUNCT O
before ADP O
and CCONJ O
after SCONJ O
the DET O
P4P PROPN B-AC
was AUX O
introduced VERB O
in ADP O
2009/2010 NUM O
. PUNCT O

The DET O
World PROPN O
Health PROPN O
Organization PROPN O
( PUNCT O
WHO PROPN O
) PUNCT O
provides VERB O
information NOUN O
( PUNCT O
in ADP O
several ADJ O
languages NOUN O
) PUNCT O
on ADP O
all DET O
aspects NOUN O
of ADP O
tuberculosis NOUN O
, PUNCT O
including VERB O
general ADJ O
information NOUN O
on ADP O
tuberculosis NOUN O
diagnostics NOUN O
and CCONJ O
specific ADJ O
information NOUN O
on ADP O
the DET O
roll NOUN O
out ADP O
of ADP O
the DET O
Xpert PROPN B-LF
MTB PROPN I-LF
/ SYM I-LF
RIF PROPN I-LF
test NOUN O
; PUNCT O
further ADJ O
information NOUN O
about ADP O
WHO PROPN O
's PART O
endorsement NOUN O
of ADP O
Xpert PROPN B-LF
MTB PROPN I-LF
/ SYM I-LF
RIF PROPN I-LF
is AUX O
included VERB O
in ADP O
a DET O
Strategic PROPN O
and CCONJ O
Technical PROPN O
Advisory PROPN O
Group PROPN O
for ADP O
Tuberculosis PROPN O
report NOUN O
; PUNCT O
the DET O
Global PROPN O
Tuberculosis PROPN O
Report PROPN O
2013 NUM O
provides VERB O
information NOUN O
about ADP O
tuberculosis NOUN O
around ADP O
the DET O
world NOUN O
, PUNCT O
including VERB O
in ADP O
India PROPN O

They PRON O
develop VERB O
from ADP O
a DET O
cylinder NOUN O
- PUNCT O
shaped ADJ O
invagination NOUN O
of ADP O
the DET O
dental ADJ O
lamina NOUN O
, PUNCT O
the DET O
so ADV O
- PUNCT O
called VERB O
dental ADJ O
epithelium NOUN O
[ X O
24–26 NUM O
] PUNCT O
, PUNCT O
where SCONJ O
tooth NOUN O
- PUNCT O
specific ADJ O
signaling NOUN O
centers NOUN O
, PUNCT O
called VERB O
primary ADJ B-LF
enamel NOUN I-LF
knots NOUN I-LF
( PUNCT O
PEKs PROPN B-AC
) PUNCT O
, PUNCT O
are AUX O
patterned VERB O
. PUNCT O

RAW264.7 NUM O
cells NOUN O
( PUNCT O
kindly ADV O
gifted VERB O
by ADP O
Ian PROPN O
Clarke PROPN O
, PUNCT O
University PROPN O
of ADP O
Southampton PROPN O
) PUNCT O
and CCONJ O
BHK-21 NOUN B-AC
cells NOUN O
( PUNCT O
obtained VERB O
from ADP O
the DET O
ATCC PROPN O
; PUNCT O
Manassas PROPN O
, PUNCT O
VA PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
were AUX O
maintained VERB O
in ADP O
high ADJ O
- PUNCT O
glucose ADJ O
Dulbecco PROPN B-LF
’s PART I-LF
Modified PROPN I-LF
Eagle PROPN I-LF
’s PART I-LF
Medium PROPN I-LF
( PUNCT O
DMEM PROPN B-AC
) PUNCT O
supplemented VERB O
with ADP O
10 NUM O
% NOUN O
( PUNCT O
v NOUN O
/ SYM O
v NOUN O
) PUNCT O
foetal ADJ O
bovine ADJ O
serum NOUN O
, PUNCT O
20 NUM O
mM NOUN O
HEPES PROPN O
buffer NOUN O
, PUNCT O
and CCONJ O
50 NUM O
U NOUN O
/ SYM O
ml NOUN O
penicillin NOUN O
and CCONJ O
streptomycin NOUN O
. PUNCT O

The DET O
nurses NOUN B-LF
’ PART I-LF
willingness NOUN I-LF
questionnaire NOUN I-LF
( PUNCT O
NWQ PROPN B-AC
) PUNCT O
was AUX O
used VERB O
to PART O
measure VERB O
the DET O
willingness NOUN O
of ADP O
nurses NOUN O
to PART O
perform VERB O
activities NOUN O
on ADP O
HIV PROPN B-AC
- PUNCT O
positive ADJ O
patients NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
DV NOUN O
= PUNCT O
dependent ADJ O
variable NOUN O
; PUNCT O
IV NOUN O
= PUNCT O
independent ADJ O
variable NOUN O
; PUNCT O
β NOUN O
= PUNCT O
standardised ADJ O
regression NOUN O
coefficient NOUN O
; PUNCT O
B NOUN O
= PUNCT O
unstandardized ADJ O
regression NOUN O
coefficient NOUN O
; PUNCT O
MVPA NOUN B-AC
= PUNCT O
moderate ADJ B-LF
to ADP I-LF
vigorous ADJ I-LF
physical ADJ I-LF
activity NOUN I-LF
; PUNCT O
6MWD NOUN B-AC
= PUNCT O
six NUM B-LF
- PUNCT I-LF
minute NOUN I-LF
walk NOUN I-LF
distance NOUN I-LF
, PUNCT O
normalised VERB O
to ADP O
height NOUN O
; PUNCT O
RCH PROPN O
= PUNCT O
The DET O
Royal PROPN O
Children PROPN O
’s PART O
Hospital PROPN O
, PUNCT O
Melbourne PROPN O
; PUNCT O
CHW PROPN O
= PUNCT O
Children PROPN O
’s PART O
Hospital PROPN O
Westmead PROPN O
, PUNCT O
Sydney PROPN O

Protein NOUN B-LF
energy NOUN I-LF
wasting NOUN I-LF
( PUNCT O
PEW NOUN B-AC
) PUNCT O
and CCONJ O
low ADJ O
physical ADJ O
activity NOUN O
could AUX O
impair VERB O
muscle NOUN O
quality NOUN O
and CCONJ O
contribute VERB O
to ADP O
muscle NOUN O
weakness NOUN O
beyond ADP O
muscle NOUN O
wasting NOUN O
in ADP O
these DET O
patients NOUN O
. PUNCT O

To PART O
address VERB O
the DET O
gap NOUN O
regarding VERB O
estimates NOUN O
on ADP O
the DET O
burden NOUN O
of ADP O
stroke NOUN O
in ADP O
Brazilian ADJ O
young ADJ O
population NOUN O
, PUNCT O
this DET O
study NOUN O
aimed VERB O
to PART O
analyze VERB O
stroke NOUN O
- PUNCT O
related VERB O
mortality NOUN O
and CCONJ O
incidence NOUN O
of ADP O
hospital NOUN O
admissions NOUN O
in ADP O
Brazilians NOUN O
aged VERB O
15 NUM O
to PART O
49 NUM O
years NOUN O
between ADP O
2008 NUM O
and CCONJ O
2012 NUM O
, PUNCT O
by ADP O
using VERB O
data NOUN O
provided VERB O
by ADP O
the DET O
Department PROPN B-LF
of ADP I-LF
Informatics PROPN I-LF
of ADP I-LF
the DET I-LF
National PROPN I-LF
Health PROPN I-LF
System PROPN I-LF
( PUNCT O
DATASUS PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
include VERB O
96.1 NUM O
% NOUN O
of ADP O
deaths NOUN O
reports NOUN O
in ADP O
the DET O
country NOUN O
[ X O
11 NUM O
] PUNCT O
and CCONJ O
is AUX O
maintained VERB O
by ADP O
the DET O
Brazilian ADJ O
Ministry PROPN O
of ADP O
Health PROPN O
. PUNCT O

Then ADV O
, PUNCT O
the DET O
DNA PROPN O
fragment NOUN O
containing VERB O
the DET O
mouse NOUN O
Ucp1 PROPN O
gene NOUN O
( PUNCT O
-3.87 NUM O
K NUM O
to PART O
+248 NUM O
( PUNCT O
upstream NOUN O
of ADP O
ATG PROPN O
) PUNCT O
) PUNCT O
, PUNCT O
an DET O
artificial ADJ O
intron NOUN O
, PUNCT O
the DET O
iRFP720 PROPN O
gene NOUN O
, PUNCT O
the DET O
bovine ADJ B-LF
growth NOUN I-LF
hormone NOUN I-LF
polyadenylation NOUN I-LF
signal NOUN I-LF
( PUNCT O
BGHpA PROPN B-AC
) PUNCT O
and CCONJ O
the DET O
mouse NOUN O
Ucp1 PROPN O
gene NOUN O
( PUNCT O
+249 NUM O
to PART O
+4.56 NUM O
K NUM O
) PUNCT O
were AUX O
inserted VERB O
sequentially ADV O
into ADP O
pBluescript PROPN O
II NUM O
KS PROPN O
( PUNCT O
- PUNCT O
) PUNCT O
vector NOUN O
. PUNCT O

Repetitive ADJ B-LF
Transcranial PROPN I-LF
Magnetic PROPN I-LF
Stimulation PROPN I-LF
[ PUNCT O
rTMS PROPN B-AC
] PUNCT O
is AUX O
increasingly ADV O
being AUX O
used VERB O
to PART O
treat VERB O
Major PROPN B-LF
Depressive PROPN I-LF
Disorder PROPN I-LF
[ PUNCT O
MDD PROPN B-AC
] PUNCT O
. PUNCT O
Given VERB O
that PRON O
not PART O
all DET O
patients NOUN O
respond VERB O
to PART O
rTMS PROPN B-AC
, PUNCT O
it PRON O
would AUX O
be AUX O
clinically ADV O
useful ADJ O
to PART O
have VERB O
reliable ADJ O
biomarkers NOUN O
that PRON O
predict VERB O
treatment NOUN O
response NOUN O
. PUNCT O

The DET O
author NOUN O
did AUX O
not PART O
find VERB O
safety NOUN O
problems NOUN O
reported VERB O
by ADP O
France PROPN O
, PUNCT O
Germany PROPN O
, PUNCT O
or CCONJ O
the DET O
United PROPN B-LF
Kingdom PROPN I-LF
( PUNCT O
UK PROPN B-AC
) PUNCT O
related VERB O
to ADP O
the DET O
five NUM O
devices NOUN O
rejected VERB O
by ADP O
the DET O
FDA PROPN B-AC
, PUNCT O
and CCONJ O
concluded VERB O
( PUNCT O
based VERB O
on ADP O
this DET O
extremely ADV O
limited ADJ O
sample NOUN O
) PUNCT O
that SCONJ O
the DET O
EU PROPN B-AC
regulatory ADJ O
system NOUN O
has VERB O
a DET O
lower ADJ O
burden NOUN O
of ADP O
proof NOUN O
for ADP O
approval NOUN O
and CCONJ O
faster ADJ O
approval NOUN O
time NOUN O
, PUNCT O
without ADP O
risk NOUN O
to ADP O
patient NOUN O
safety NOUN O
. PUNCT O

BW NOUN B-AC
= PUNCT O
body NOUN B-LF
weight NOUN I-LF
. PUNCT O

GalT PROPN B-AC
- PUNCT O
GFP PROPN B-AC
, PUNCT O
GalT PROPN B-AC
fused VERB O
with ADP O
GFP PROPN B-AC
; PUNCT O
Hrs PROPN B-AC
, PUNCT O
hepatocyte NOUN B-LF
growth NOUN I-LF
factor NOUN I-LF
- PUNCT I-LF
regulated VERB I-LF
tyrosine NOUN I-LF
kinase NOUN I-LF
substrate NOUN I-LF
; PUNCT O
Rab5 PROPN B-AC
, PUNCT O
Rabaptin PROPN O
5 NUM O
; PUNCT O
RNAi NOUN B-AC
, PUNCT O
RNA NOUN B-LF
interference NOUN I-LF
. PUNCT O

Similarly ADV O
, PUNCT O
using VERB O
Microsoft PROPN O
Office PROPN O
Excel PROPN O
the DET O
breed NOUN O
- PUNCT O
specific ADJ O
SNP NOUN B-LF
database NOUN I-LF
of ADP O
bovine ADJ O
pituitary ADJ O
gland NOUN O
were AUX O
further ADV O
trimmed VERB O
to ADP O
a DET O
highly ADV O
reliable ADJ O
breed NOUN O
- PUNCT O
specific ADJ O
SNP NOUN B-AC
- PUNCT B-AC
db NOUN B-AC
according VERB O
to ADP O
SNP NOUN B-AC
type NOUN O
, PUNCT O
de X O
novo X O
SNP NOUN B-AC
and CCONJ O
annotated VERB O
SNPs NOUN B-AC
, PUNCT O
respectively ADV O
. PUNCT O

PAD PROPN O
. PUNCT O
peripheral ADJ O
artery NOUN O
disease NOUN O
; PUNCT O
CVD NOUN O
. PUNCT O
cerebrovascular ADJ O
disease NOUN O
; PUNCT O
TIA PROPN O
. PUNCT O
transient ADJ O
ischemic ADJ O
attack NOUN O
; PUNCT O
CAD NOUN B-AC
. PUNCT O
coronary ADJ B-LF
artery NOUN I-LF
disease NOUN I-LF
; PUNCT O
LVEF PROPN B-AC
. PUNCT O
left ADJ B-LF
ventricle ADJ I-LF
ejection NOUN I-LF
fraction NOUN I-LF
; PUNCT O
IABP PROPN B-AC
. PUNCT O
intra ADJ B-LF
- ADJ I-LF
aortic ADJ I-LF
balloon NOUN I-LF
pump NOUN I-LF
; PUNCT O
LAAO PROPN O
. PUNCT O
left ADJ O
atrial ADJ O
appendage NOUN O
occlusion NOUN O
. PUNCT O

M NOUN O
, PUNCT O
Minus X O
; PUNCT O
map NOUN B-AC
, PUNCT O
mating NOUN B-LF
type NOUN I-LF
auxiliary ADJ I-LF
plus NOUN I-LF
; PUNCT O
mfm NOUN B-AC
, PUNCT O
mating NOUN B-LF
factor NOUN I-LF
minus NOUN I-LF
; PUNCT O
P NOUN O
, PUNCT O
Plus NOUN O
; PUNCT O
So PROPN B-AC
, PUNCT O
Schizosaccharomyces NOUN B-LF
octosporus NOUN I-LF
; PUNCT O
Sp PROPN B-AC
, PUNCT O
Schizosaccharomyces NOUN B-LF
pombe NOUN I-LF
. PUNCT O

In ADP O
addition NOUN O
, PUNCT O
an DET O
aliquot NOUN O
of ADP O
supernatant NOUN B-LF
was AUX O
incubated VERB O
with ADP O
VSV PROPN B-AC
- PUNCT O
NJ PROPN O
neutralizing VERB O
mAb NOUN B-AC
H6B9D5 PROPN O
prior ADV O
to PART O
testing VERB O
the DET O
remaining VERB O
infectivity NOUN O
[ PUNCT O
see VERB O
PFU PROPN B-AC
/ SYM O
ml PROPN O
SN PROPN B-AC
( SYM O
+ SYM O
VSV PROPN B-AC
- PUNCT O
NJ PROPN O
nAb PROPN B-AC
) PUNCT O
] PUNCT O
to PART O
discriminate VERB O
rLCMV NOUN B-AC
/ SYM B-AC
INDG PROPN B-AC
from ADP O
rLCMV NOUN B-AC
/ SYM B-AC
NJG PROPN B-AC
infectivity NOUN O
. PUNCT O

Few ADJ O
published VERB O
postoperative ADJ O
risk NOUN O
prediction NOUN O
models NOUN O
using VERB O
electronic ADJ B-LF
health NOUN I-LF
record NOUN I-LF
( PUNCT O
EHR PROPN B-AC
) PUNCT O
data NOUN O
exist VERB O
. PUNCT O

This PRON O
results VERB O
in ADP O
a DET O
Matthews PROPN B-LF
correlation NOUN I-LF
coefficient NOUN I-LF
( PUNCT O
MCC PROPN B-AC
) PUNCT O
of ADP O
0.983 NUM O
. PUNCT O

Here ADV O
, PUNCT O
we PRON O
demonstrate VERB O
an DET O
unexpected ADJ O
role NOUN O
of ADP O
LSM12 PROPN B-AC
and CCONJ O
its PRON O
downstream ADJ O
effector NOUN O
, PUNCT O
exchange NOUN B-LF
protein NOUN I-LF
directly ADV I-LF
activated VERB I-LF
by ADP I-LF
cyclic ADJ I-LF
AMP PROPN I-LF
1 NUM I-LF
( PUNCT O
EPAC1 PROPN B-AC
; PUNCT O
also ADV O
known VERB O
as ADP O
RAPGEF3 PROPN O
) PUNCT O
in ADP O
establishing VERB O
a DET O
robust ADJ O
nucleocytoplasmic NOUN O
gradient NOUN O
of ADP O
RAN PROPN O
- PUNCT O
GTP PROPN O
. PUNCT O
Consequently ADV O
, PUNCT O
LSM12 PROPN B-AC
- PUNCT O
EPAC1 PROPN B-AC
constitutes VERB O
an DET O
ATXN2 NOUN B-AC
- PUNCT O
independent ADJ O
neuroprotective ADJ O
pathway NOUN O
that PRON O
sustains VERB O
NCT PROPN B-AC
and CCONJ O
suppresses VERB O
the DET O
cellular ADJ O
pathogenesis NOUN O
of ADP O
poly(GR)-induced ADJ O
neurodegeneration NOUN O
. PUNCT O

FSEC PROPN B-AC
, PUNCT O
fluorescence NOUN B-LF
detection NOUN I-LF
size NOUN I-LF
exclusion NOUN I-LF
chromatography NOUN I-LF
. PUNCT O

CRC PROPN B-AC
, PUNCT O
colorectal ADJ B-LF
cancer NOUN I-LF
; PUNCT O
DM NOUN B-AC
, PUNCT O
diabetes NOUN B-LF
mellitus NOUN I-LF
; PUNCT O
FDR NOUN B-AC
, PUNCT O
first ADJ B-LF
- PUNCT I-LF
degree NOUN I-LF
relative NOUN I-LF
. PUNCT O

DO VERB B-AC
, PUNCT O
H2 PROPN O
- PUNCT O
O PROPN O
; PUNCT O
DR1 PROPN B-AC
, PUNCT O
HLA PROPN B-LF
- PUNCT I-LF
DR1 PROPN I-LF
; PUNCT O
KO NOUN B-AC
, PUNCT O
knockout NOUN B-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

The DET O
proteins NOUN O
were AUX O
then ADV O
assayed VERB O
for ADP O
dithiothreitol NOUN B-LF
( PUNCT O
DTT)- NOUN B-AC
and CCONJ O
Trx NOUN B-AC
- PUNCT O
dependent ADJ O
Met NOUN B-AC
- PUNCT B-AC
SO NOUN B-AC
reduction NOUN O
. PUNCT O

A DET O
helper ADJ O
plasmid NOUN O
FHR PROPN O
, PUNCT O
that PRON O
is AUX O
nonmobile ADJ O
and CCONJ O
thus ADV O
behaves VERB O
like ADP O
a DET O
chromosomal ADJ O
allele NOUN O
, PUNCT O
governs VERB O
the DET O
host NOUN O
cell NOUN O
donor NOUN O
ability NOUN O
for ADP O
a DET O
mobile ADJ O
plasmid NOUN O
C PROPN O
, PUNCT O
which PRON O
confers VERB O
chloramphenicol NOUN B-LF
( PUNCT O
Cm PROPN B-AC
) PUNCT O
resistance NOUN O
. PUNCT O

Mean ADJ B-LF
differences NOUN I-LF
( PUNCT O
MDs NOUN B-AC
) PUNCT O
with ADP O
95 NUM O
% NOUN O
CIs NOUN B-AC
were AUX O
calculated VERB O
for ADP O
continuous ADJ O
outcomes NOUN O
. PUNCT O

FDC PROPN B-AC
, PUNCT O
single ADJ B-LF
- PUNCT I-LF
pill NOUN I-LF
fixed ADJ I-LF
- PUNCT I-LF
dose NOUN I-LF
combination NOUN I-LF
. PUNCT O

( PUNCT O
A X O
) PUNCT O
Standard ADJ O
histology NOUN O
immunostaining NOUN O
for ADP O
high ADJ O
molecular ADJ O
weight NOUN O
cytokeratins NOUN O
and CCONJ O
p63 NOUN O
( PUNCT O
basal ADJ O
cell NOUN O
markers NOUN O
in ADP O
brown ADJ O
) PUNCT O
and CCONJ O
α NOUN O
- PUNCT O
methylacyl NOUN O
- PUNCT O
CoA NOUN O
racemase NOUN O
( PUNCT O
cancer NOUN O
cell NOUN O
marker NOUN O
in ADP O
red ADJ O
) PUNCT O
, PUNCT O
followed VERB O
by ADP O
hematoxylin NOUN B-LF
and CCONJ I-LF
eosin NOUN I-LF
( PUNCT O
H&E PROPN B-AC
) PUNCT O
counterstaining VERB O
to PART O
identify VERB O
high ADJ B-LF
- PUNCT I-LF
grade NOUN I-LF
prostatic ADJ I-LF
intraepithelial ADJ I-LF
neoplasia NOUN I-LF
( PUNCT O
HGPIN PROPN B-AC
) PUNCT O
and CCONJ O
intraductal ADJ B-LF
carcinoma NOUN I-LF
of ADP I-LF
the DET I-LF
prostate NOUN I-LF
( PUNCT O
IDC PROPN B-AC
- PUNCT B-AC
P PROPN B-AC
) PUNCT O
along ADP O
with ADP O
adjacent ADJ O
cancer NOUN O
. PUNCT O

Aβ NOUN B-AC
, PUNCT O
amyloid NOUN B-LF
- PUNCT I-LF
beta NOUN I-LF
; PUNCT O
B NOUN O
, PUNCT O
unstandardized ADJ O
regression NOUN O
coefficient NOUN O
; PUNCT O
OR NOUN O
, PUNCT O
odds NOUN O
ratio NOUN O
; PUNCT O
SD NOUN B-AC
, PUNCT O
standard ADJ B-LF
drink NOUN I-LF
; PUNCT O
SUVR PROPN B-AC
, PUNCT O
standardized ADJ B-LF
uptake NOUN I-LF
value NOUN I-LF
ratio NOUN I-LF
. PUNCT O

Abbreviation NOUN O
: PUNCT O
VL PROPN B-AC
, PUNCT O
viral ADJ B-LF
load NOUN I-LF
. PUNCT O

Dub NOUN B-AC
- PUNCT B-AC
seq NOUN B-AC
, PUNCT O
dual ADJ B-LF
- PUNCT I-LF
barcoded NOUN I-LF
shotgun NOUN I-LF
expression NOUN I-LF
library NOUN I-LF
sequencing NOUN I-LF
. PUNCT O

AMI PROPN B-AC
, PUNCT O
acute ADJ B-LF
myocardial ADJ I-LF
infarction NOUN I-LF
; PUNCT O
COPD PROPN B-AC
, PUNCT O
chronic ADJ B-LF
obstructive ADJ I-LF
pulmonary ADJ I-LF
disease NOUN I-LF
; PUNCT O
eGFR PROPN B-AC
, PUNCT O
estimated VERB B-LF
glomerular ADJ I-LF
filtration NOUN I-LF
rate NOUN I-LF
; PUNCT O
HR NOUN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT O
LVEF PROPN B-AC
, PUNCT O
left ADJ B-LF
ventricular ADJ I-LF
ejection NOUN I-LF
fraction NOUN I-LF
. PUNCT O

We PRON O
selected VERB O
the DET O
fourth ADJ O
sniff NOUN O
- PUNCT O
response NOUN O
during ADP O
ethyl NOUN O
butyrate NOUN O
presentation NOUN O
as ADP O
the DET O
basis NOUN O
for ADP O
our PRON O
movie NOUN O
( PUNCT O
between ADP O
vertical ADJ O
lines NOUN O
, PUNCT O
magnified VERB O
in SCONJ O
D NOUN O
) PUNCT O
. PUNCT O
Traces NOUN O
were AUX O
deconvolved VERB O
( PUNCT O
deconv NOUN O
) PUNCT O
with ADP O
a DET O
610 NUM O
ms NOUN O
off ADP O
- PUNCT O
time NOUN O
constant NOUN O
to PART O
yield VERB O
the DET O
red ADJ O
traces NOUN O
. PUNCT O
fps NOUN B-AC
: PUNCT O
frames NOUN B-LF
per ADP I-LF
second NOUN I-LF
. PUNCT O
( PUNCT O
D NOUN O
) PUNCT O
The DET O
temporal ADJ O
dynamics NOUN O
of ADP O
the DET O
S+ NOUN O
movie NOUN O
between ADP O
the DET O
anterior ADJ O
and CCONJ O
posterior ADJ O
ROI NOUN O
differ VERB O
( PUNCT O
red ADJ O
traces NOUN O
) PUNCT O
, PUNCT O
in SCONJ O
that SCONJ O
the DET O
anterior ADJ O
ROI NOUN O
turns VERB O
on ADP O
and CCONJ O
off ADP O
more ADV O
slowly ADV O
. PUNCT O

Hypoxia NOUN B-LF
/ SYM I-LF
normoxia NOUN I-LF
( PUNCT O
H NOUN B-AC
/ SYM B-AC
N NOUN B-AC
) PUNCT O
caused VERB O
50 NUM O
% NOUN O
drop NOUN O
in ADP O
cell NOUN O
viability NOUN O
of ADP O
AGS PROPN O
, PUNCT O
RIE1 PROPN O
and CCONJ O
Caco-2 PROPN O
cells NOUN O
but CCONJ O
PSTI NOUN B-AC
( PUNCT O
10 NUM O
μg NOUN O
/ SYM O
ml NOUN O
) PUNCT O
given VERB O
prior- ADJ O
or CCONJ O
during ADP O
- PUNCT O
hypoxic ADJ O
period NOUN O
improved VERB O
survival NOUN O
by ADP O
50 NUM O
% NOUN O
( PUNCT O
p<0.01 NUM O
) PUNCT O
. PUNCT O

To PART O
further ADV O
investigate VERB O
the DET O
role NOUN O
of ADP O
SNX3 PROPN O
in ADP O
early ADJ O
- PUNCT O
to ADP O
- PUNCT O
late ADJ O
endosome NOUN O
transport NOUN O
, PUNCT O
we PRON O
made VERB O
use NOUN O
of ADP O
vesicular ADJ B-LF
stomatitis NOUN I-LF
virus NOUN I-LF
( PUNCT O
VSV PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
infects VERB O
cells NOUN O
from ADP O
the DET O
endocytic ADJ O
pathway NOUN O
. PUNCT O

RT NOUN B-AC
= PUNCT O
Retention NOUN B-LF
Time NOUN I-LF
; PUNCT O
m NOUN B-AC
/ SYM B-AC
z NOUN B-AC
= PUNCT O
mass NOUN B-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
charge NOUN I-LF
ratio NOUN I-LF
; PUNCT O
ppm NOUN B-AC
= PUNCT O
part NOUN B-LF
per ADP I-LF
million NUM I-LF
; PUNCT O
AUC NOUN B-AC
= PUNCT O
Area NOUN B-LF
under ADP I-LF
the DET I-LF
Curve NOUN I-LF
; PUNCT O
ROC NOUN B-AC
= PUNCT O
receiver NOUN B-LF
operating NOUN I-LF
characteristics NOUN I-LF
; PUNCT O
Sp NOUN B-AC
= PUNCT O
specificity NOUN B-LF
; PUNCT O
Se NOUN B-AC
= PUNCT O
sensitivity NOUN B-LF
; PUNCT O
the DET O
optimal ADJ O
threshold NOUN O
used VERB O
for ADP O
specificity NOUN B-LF
and CCONJ O
sensitivity NOUN B-LF
is AUX O
the DET O
point NOUN O
closest ADJ O
to ADP O
the DET O
top ADJ O
- PUNCT O
left ADJ O
part NOUN O
of ADP O
the DET O
plot NOUN O
with ADP O
perfect ADJ O
sensitivity NOUN B-LF
or CCONJ O
specificity NOUN B-LF
. PUNCT O

REE X B-AC
: PUNCT O
resting VERB B-LF
energy NOUN I-LF
expenditure NOUN I-LF

EPL PROPN B-AC
, PUNCT O
external ADJ B-LF
plexiform ADJ I-LF
layer NOUN I-LF
; PUNCT O
LFP PROPN B-AC
, PUNCT O
local ADJ B-LF
field NOUN I-LF
potential NOUN I-LF
; PUNCT O
MCL PROPN B-AC
, PUNCT O
mitral ADJ B-LF
cell NOUN I-LF
layer NOUN I-LF
; PUNCT O
MTC PROPN B-AC
, PUNCT O
mitral ADJ B-LF
and CCONJ I-LF
tufted ADJ I-LF
cell NOUN I-LF
; PUNCT O
MUA PROPN B-AC
, PUNCT O
multiunit NOUN B-LF
activity NOUN I-LF
; PUNCT O
OB NOUN B-AC
, PUNCT O
olfactory NOUN B-LF
bulb NOUN I-LF
; PUNCT O
P NOUN O
, PUNCT O
postnatal ADJ O
day NOUN O
; PUNCT O
RR NOUN B-AC
, PUNCT O
respiration NOUN B-LF
- PUNCT I-LF
related VERB I-LF
rhythm NOUN I-LF
. PUNCT O

Abbreviations NOUN O
: PUNCT O
BC1 PROPN B-AC
first ADJ B-LF
breast NOUN I-LF
cancer NOUN I-LF
, PUNCT O
BC2 PROPN B-AC
second ADJ B-LF
breast NOUN I-LF
cancer NOUN I-LF
, PUNCT O
CBC PROPN B-AC
Contralateral ADJ B-LF
breast NOUN I-LF
cancer NOUN I-LF
, PUNCT O
EGFR PROPN B-AC
Epidermial ADJ O
growth NOUN O
factor NOUN O
receptor NOUN O
, PUNCT O
ER PROPN O
Estrogen PROPN O
receptor NOUN O
, PUNCT O
HIF PROPN B-AC
Hypoxia NOUN B-LF
- PUNCT I-LF
inducible ADJ I-LF
factor NOUN I-LF
. PUNCT O

Participants NOUN O
were AUX O
randomized VERB O
into ADP O
three NUM O
arms NOUN O
: PUNCT O
melarsoprol NOUN B-LF
- PUNCT I-LF
nifurtimox NOUN I-LF
( PUNCT O
M+N NOUN B-AC
) PUNCT O
, PUNCT O
melarsoprol NOUN B-LF
- PUNCT I-LF
eflornithine NOUN I-LF
( PUNCT O
M+E NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
nifurtimox NOUN B-LF
- PUNCT I-LF
eflornithine NOUN I-LF
( PUNCT O
N+E NOUN B-AC
) PUNCT O
. PUNCT O

MSP-119 PROPN B-AC
is AUX O
made VERB O
up ADP O
of ADP O
two NUM O
epidermal ADJ B-LF
growth NOUN I-LF
factor NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
modules NOUN I-LF
( PUNCT O
EGF-1 PROPN B-AC
and CCONJ O
EGF-2 NOUN B-AC
) PUNCT O
. PUNCT O

These DET O
responses NOUN O
involve VERB O
activation NOUN O
of ADP O
protein NOUN B-LF
kinase NOUN I-LF
R PROPN I-LF
( PUNCT O
PKR PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
leads VERB O
to ADP O
translational ADJ O
arrest NOUN O
[ X O
28 NUM O
] PUNCT O
and CCONJ O
formation NOUN O
of ADP O
stress NOUN O
granules NOUN O
[ X O
22,30 NUM O
] PUNCT O
. PUNCT O

Significance ADJ O
P NOUN O
values NOUN O
were AUX O
calculated VERB O
using VERB O
Tukey PROPN O
's PART O
multiple ADJ O
comparison NOUN O
test NOUN O
. PUNCT O
cont PROPN O
, PUNCT O
control NOUN O
; PUNCT O
Fgf7 PROPN B-AC
, PUNCT O
fibroblast NOUN B-LF
growth NOUN I-LF
factor NOUN I-LF
7 NUM I-LF
; PUNCT O
rhFGF7 PROPN B-AC
, PUNCT O
recombinant ADJ B-LF
human ADJ I-LF
FGF7 NOUN I-LF
; PUNCT O
RT NOUN B-AC
- PUNCT B-AC
qPCR NOUN B-AC
, PUNCT O
reverse ADJ B-LF
transcriptase NOUN I-LF
- PUNCT I-LF
quantitative ADJ I-LF
PCR NOUN I-LF
; PUNCT O
Spp1 NOUN B-AC
, PUNCT O
secreted VERB B-LF
phosphoprotein NOUN I-LF
1 NUM I-LF
. PUNCT O

Dendritic ADJ B-LF
cells NOUN I-LF
( PUNCT O
DCs PROPN B-AC
) PUNCT O
are AUX O
regarded VERB O
as ADP O
the DET O
most ADV O
potent ADJ O
antigen NOUN B-LF
presenting VERB I-LF
cells NOUN I-LF
( PUNCT O
APCs PROPN B-AC
) PUNCT O
for ADP O
induction NOUN O
of ADP O
( PUNCT O
cancer NOUN O
) PUNCT O
antigen NOUN O
- PUNCT O
specific ADJ O
CD8 PROPN O
+ NOUN O
T PROPN O
cell NOUN O
responses NOUN O
. PUNCT O

The DET O
Self PROPN B-LF
Reporting PROPN I-LF
Questionnaire-20 PROPN I-LF
( PUNCT O
SRQ-20 NOUN B-AC
) PUNCT O
is AUX O
a DET O
WHO PROPN O
- PUNCT O
endorsed VERB O
measure NOUN O
of ADP O
psychological ADJ O
distress NOUN O
[ PUNCT O
31 NUM O
] PUNCT O
. PUNCT O

α NOUN B-LF
- PUNCT I-LF
Galactosylceramide NOUN I-LF
( PUNCT O
αGC PROPN B-AC
) PUNCT O
was AUX O
purchased VERB O
from ADP O
Avanti PROPN O
Polar PROPN O
Lipids PROPN O
. PUNCT O

To PART O
test VERB O
this DET O
hypothesis NOUN O
, PUNCT O
rats NOUN O
were AUX O
fed VERB O
a DET O
control NOUN B-LF
diet NOUN I-LF
( PUNCT O
CD NOUN B-AC
) PUNCT O
or CCONJ O
high ADJ O
fat NOUN O
isocaloric ADJ O
diets NOUN O
containing VERB O
either CCONJ O
ω-3 NUM O
PUFA NOUN B-AC
( PUNCT O
FD NOUN B-AC
) PUNCT O
or CCONJ O
lard NOUN O
( PUNCT O
LD NOUN B-AC
) PUNCT O
for ADP O
6 NUM O
weeks NOUN O
. PUNCT O

ChIP PROPN B-AC
, PUNCT O
chromatin NOUN B-LF
immunoprecipitation NOUN I-LF
; PUNCT O
RT NOUN B-AC
- PUNCT B-AC
QPCR PROPN B-AC
, PUNCT O
quantitative ADJ B-LF
real ADJ I-LF
- PUNCT I-LF
time NOUN I-LF
PCR NOUN I-LF
. PUNCT O

AV PROPN B-AC
, PUNCT O
animal NOUN B-LF
– PUNCT I-LF
vegetal NOUN I-LF
; PUNCT O
hpf NOUN B-AC
, PUNCT O
hours NOUN B-LF
post X I-LF
fertilization NOUN I-LF
; PUNCT O
pSmad5 PROPN B-AC
, PUNCT O
phosphorylated VERB B-LF
Smad5 PROPN I-LF
; PUNCT O
WT PROPN O
, PUNCT O
wild ADJ O
- PUNCT O
type NOUN O
. PUNCT O

Current ADJ O
clinical ADJ O
trials NOUN O
involving VERB O
CAR PROPN B-AC
T PROPN O
cell NOUN O
therapy NOUN O
in ADP O
GC PROPN B-AC
patients NOUN O
are AUX O
targeting VERB O
HER2 PROPN B-AC
, PUNCT O
CEA PROPN B-AC
, PUNCT O
Mucin-1 PROPN O
, PUNCT O
and CCONJ O
epithelial ADJ B-LF
cell NOUN I-LF
adhesion NOUN I-LF
molecule NOUN I-LF
( PUNCT O
EpCAM PROPN B-AC
) PUNCT O
[ PUNCT O
17 NUM O
] PUNCT O
. PUNCT O

BHDS PROPN B-AC
: PUNCT O
Birt PROPN B-LF
- PUNCT I-LF
Hogg PROPN I-LF
- PUNCT I-LF
Dubé PROPN I-LF
syndrome NOUN I-LF
; PUNCT O
COPD PROPN B-AC
: PUNCT O
chronic ADJ B-LF
obstructive ADJ I-LF
pulmonary ADJ I-LF
disease NOUN I-LF
; PUNCT O
LAM PROPN B-AC
: PUNCT O
lymphangioleiomyomatosis NOUN B-LF
. PUNCT O

We PRON O
used VERB O
a DET O
conservative ADJ O
nonlinear ADJ O
risk NOUN O
relationship NOUN O
generated VERB O
using VERB O
both CCONJ O
ambient ADJ O
and CCONJ O
HAP PROPN B-AC
studies NOUN O
and CCONJ O
with ADP O
uncertainty NOUN B-LF
intervals NOUN I-LF
( PUNCT O
UIs NOUN B-AC
) PUNCT O
accounting VERB O
for ADP O
between ADP O
- PUNCT O
study NOUN O
heterogeneity NOUN O
in ADP O
risk NOUN O
estimates NOUN O
. PUNCT O

To PART O
inform VERB O
the DET O
current ADJ O
review NOUN O
of ADP O
this DET O
legislation NOUN O
, PUNCT O
this DET O
paper NOUN O
aims VERB O
to ADP O
explore VERB O
transnational ADJ B-LF
tobacco NOUN I-LF
company NOUN I-LF
( PUNCT O
TTC PROPN B-AC
) PUNCT O
interests NOUN O
in ADP O
SLT PROPN B-AC
and CCONJ O
pure ADJ O
nicotine NOUN O
in ADP O
Europe PROPN O
from ADP O
the DET O
1970s NOUN O
to ADP O
the DET O
present NOUN O
, PUNCT O
comparing VERB O
them PRON O
with ADP O
TTCs PROPN B-AC
' PART O
public ADJ O
claims NOUN O
of ADP O
support NOUN O
for ADP O
harm NOUN O
reduction NOUN O
. PUNCT O

MPA PROPN B-AC
, PUNCT O
marine NOUN B-LF
protected VERB I-LF
area NOUN I-LF
. PUNCT O

In ADP O
a DET O
sample NOUN O
of ADP O
1818 NUM O
participants NOUN O
( PUNCT O
52 NUM O
% NOUN O
female ADJ O
, PUNCT O
mean ADJ O
age NOUN O
54±12 NUM O
years NOUN O
) PUNCT O
global ADJ B-LF
longitudinal ADJ I-LF
peak NOUN I-LF
systolic NOUN I-LF
strain NOUN I-LF
( PUNCT O
GL PROPN B-AC
- PUNCT B-AC
PSS PROPN B-AC
, PUNCT O
n NOUN O
= SYM O
1218 NUM O
) PUNCT O
, PUNCT O
systolic NOUN O
( PUNCT O
GL PROPN B-AC
- PUNCT B-AC
SSR PROPN B-AC
, PUNCT O
n NOUN O
= SYM O
1506 NUM O
) PUNCT O
, PUNCT O
and CCONJ O
early ADJ O
( PUNCT O
GL PROPN B-AC
- PUNCT B-AC
EDSR PROPN B-AC
, PUNCT O
n NOUN O
= SYM O
1506 NUM O
) PUNCT O
and CCONJ O
late ADJ O
diastolic ADJ O
strain NOUN O
rates NOUN O
( PUNCT O
GL PROPN B-AC
- PUNCT B-AC
LDSR PROPN B-AC
, PUNCT O
n NOUN O
= SYM O
1500 NUM O
) PUNCT O
were AUX O
derived VERB O
from ADP O
2D ADJ O
speckle NOUN O
tracking NOUN O
analysis NOUN O
. PUNCT O

Here ADV O
we PRON O
distinguish VERB O
2 NUM O
types NOUN O
of ADP O
microcephaly NOUN O
: PUNCT O
morphological ADJ B-LF
microcephaly NOUN I-LF
( PUNCT O
MM PROPN B-AC
) PUNCT O
and CCONJ O
microcephaly NOUN O
with ADP O
structural ADJ O
CNS PROPN B-AC
defects NOUN O
( PUNCT O
hereafter ADV O
termed VERB O
microcephaly NOUN B-LF
with ADP I-LF
structural ADJ I-LF
brain NOUN I-LF
defects NOUN I-LF
[ PUNCT O
MWSD PROPN B-AC
] PUNCT O
) PUNCT O
, PUNCT O
originally ADV O
reported VERB O
as ADP O
‘ PUNCT O
suspected ADJ O
microcephaly NOUN O
’ PUNCT O
and CCONJ O
‘ PUNCT O
confirmed VERB O
microcephaly NOUN O
’ PUNCT O
, PUNCT O
respectively ADV O
. PUNCT O

We PRON O
used VERB O
the DET O
International PROPN B-LF
Classification PROPN I-LF
of ADP I-LF
Diseases PROPN I-LF
, PUNCT I-LF
Ninth PROPN I-LF
Revision PROPN I-LF
, PUNCT I-LF
Clinical PROPN I-LF
Modification PROPN I-LF
( PUNCT O
ICD-9 PROPN B-AC
- PUNCT B-AC
CM PROPN B-AC
) PUNCT O
to PART O
define VERB O
preoperative ADJ O
coexisting ADJ O
medical ADJ O
conditions NOUN O
and CCONJ O
postoperative ADJ O
complications NOUN O
. PUNCT O

This DET O
paper NOUN O
reports VERB O
on ADP O
findings NOUN O
from ADP O
cluster NOUN O
- PUNCT O
randomized VERB O
impact NOUN O
evaluations NOUN O
of ADP O
two NUM O
at ADP O
- PUNCT O
scale NOUN O
programs NOUN O
, PUNCT O
in ADP O
Bangladesh PROPN O
and CCONJ O
Viet PROPN O
Nam PROPN O
, PUNCT O
that PRON O
provided VERB O
intensified VERB O
interpersonal ADJ B-LF
counseling NOUN I-LF
( PUNCT O
IPC PROPN B-AC
) PUNCT O
to PART O
pregnant ADJ O
women NOUN O
and CCONJ O
mothers NOUN O
of ADP O
children NOUN O
up ADP O
to PART O
2 NUM O
y NOUN O
of ADP O
age NOUN O
, PUNCT O
combined VERB O
with ADP O
mass NOUN B-LF
media NOUN I-LF
( PUNCT O
MM PROPN B-AC
) PUNCT O
, PUNCT O
community NOUN B-LF
mobilization NOUN I-LF
( PUNCT O
CM PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
policy NOUN B-LF
advocacy NOUN I-LF
( PUNCT O
PA PROPN B-AC
) PUNCT O
intervention NOUN O
components NOUN O
, PUNCT O
to PART O
improve VERB O
breastfeeding NOUN O
practices NOUN O
[ PUNCT O
20 NUM O
] PUNCT O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
d NOUN B-AC
- NOUN B-AC
ManNAc PROPN B-AC
, PUNCT O
N NOUN B-LF
- NOUN I-LF
acetyl NOUN I-LF
- NOUN I-LF
d NOUN I-LF
- NOUN I-LF
mannosamine NOUN I-LF
; PUNCT O
d NOUN B-AC
- NOUN B-AC
ManNAcA PROPN B-AC
, PUNCT O
N NOUN B-LF
- NOUN I-LF
acetyl NOUN I-LF
- NOUN I-LF
d NOUN I-LF
- NOUN I-LF
mannosaminuronic NOUN I-LF
acid NOUN I-LF
; PUNCT O
ppm NOUN B-AC
, PUNCT O
parts NOUN B-LF
per ADP I-LF
million NUM I-LF
. PUNCT O

Protein NOUN B-LF
kinase NOUN I-LF
C PROPN I-LF
( PUNCT O
PKC PROPN B-AC
) PUNCT O
inhibitors NOUN O
( PUNCT O
Ro318425 PROPN O
, PUNCT O
Gö6983 PROPN O
, PUNCT O
Gö6976 PROPN O
) PUNCT O
targeting VERB O
classical ADJ O
and CCONJ O
atypical ADJ O
PKCs NOUN B-AC
, PUNCT O
and CCONJ O
the DET O
inhibitor NOUN O
PKC412 PROPN O
, PUNCT O
which PRON O
mainly ADV O
inhibits VERB O
classical ADJ O
PKCs NOUN B-AC
, PUNCT O
all PRON O
substantially ADV O
blocked VERB O
PKB PROPN B-AC
/ SYM B-AC
Akt PROPN B-AC
phosphorylation NOUN O
in ADP O
response NOUN O
to ADP O
thapsigargin NOUN O
and CCONJ O
phorbol NOUN B-LF
12 NUM I-LF
- PUNCT I-LF
myristate NOUN I-LF
13 NUM I-LF
- PUNCT I-LF
acetate NOUN I-LF
( PUNCT O
PMA PROPN B-AC
) PUNCT O
( PUNCT O
Figures NOUN O
3A NUM O
and CCONJ O
S2A NOUN O
) PUNCT O
. PUNCT O
Rottlerin PROPN O
, PUNCT O
with ADP O
a DET O
limited ADJ O
selectivity NOUN O
for ADP O
PKCδ PROPN O
, PUNCT O
had VERB O
no DET O
effect NOUN O
on ADP O
PKB PROPN B-AC
/ SYM B-AC
Akt PROPN B-AC
activation NOUN O
. PUNCT O

Fresh ADJ O
and CCONJ O
dried VERB O
plant NOUN O
extracts NOUN O
of ADP O
the DET O
various ADJ O
solvents NOUN O
( PUNCT O
aqueous NOUN O
, PUNCT O
acetone NOUN O
& CCONJ O
ethanol NOUN O
) PUNCT O
were AUX O
weighed VERB O
and CCONJ O
dissolved VERB O
in ADP O
dimethyl NOUN B-LF
sulfoxide NOUN I-LF
( PUNCT O
DMSO PROPN B-AC
) PUNCT O
. PUNCT O
They PRON O
were AUX O
then ADV O
all PRON O
sonicated VERB O
for ADP O
proper ADJ O
solubilization NOUN O
and CCONJ O
stored VERB O
at ADP O
-20 NUM O
° NOUN O
C NOUN O
. PUNCT O

Hemodynamics NOUN O
including VERB O
heart NOUN B-LF
rate NOUN I-LF
( PUNCT O
HR NOUN B-AC
) PUNCT O
, PUNCT O
AP PROPN B-AC
, PUNCT O
CO PROPN B-AC
, PUNCT O
LVAD NOUN B-AC
flow NOUN O
, PUNCT O
RAP PROPN B-AC
and CCONJ O
LAP PROPN B-AC
were AUX O
recorded VERB O
simultaneously ADV O
. PUNCT O

To PART O
determine VERB O
the DET O
expression NOUN O
of ADP O
SmInAct PROPN B-AC
at ADP O
the DET O
transcript NOUN O
level NOUN O
, PUNCT O
real ADJ O
- PUNCT O
time NOUN O
reverse ADJ B-LF
transcriptase NOUN I-LF
– PUNCT I-LF
polymerase NOUN I-LF
chain NOUN I-LF
reaction NOUN I-LF
( PUNCT O
RT PROPN B-AC
- PUNCT B-AC
PCR PROPN B-AC
) PUNCT O
was AUX O
performed VERB O
on ADP O
cDNA NOUN O
from ADP O
eggs NOUN O
, PUNCT O
adult ADJ O
male ADJ O
parasites NOUN O
, PUNCT O
and CCONJ O
adult ADJ O
female ADJ O
parasites NOUN O
from ADP O
mixed VERB O
- PUNCT O
sex NOUN O
infections NOUN O
. PUNCT O

We PRON O
also ADV O
detected VERB O
amplification NOUN O
of ADP O
both CCONJ O
enabled ADJ O
homolog NOUN O
( PUNCT O
ENAH PROPN B-AC
) PUNCT O
and CCONJ O
poly NOUN B-LF
[ PUNCT I-LF
ADP NOUN I-LF
- PUNCT I-LF
ribose NOUN I-LF
] PUNCT I-LF
polymerase NOUN I-LF
1 NUM I-LF
( PUNCT O
PARP1 PROPN B-AC
) PUNCT O
in ADP O
CH157 PROPN O
- PUNCT O
MN PROPN O
, PUNCT O
although SCONJ O
these DET O
genes NOUN O
have AUX O
not PART O
previously ADV O
been AUX O
implicated VERB O
in ADP O
meningiomas NOUN O
tumorigenesis NOUN O
[ PUNCT O
30 NUM O
, PUNCT O
31 NUM O
] PUNCT O
. PUNCT O

Phagocytosis NOUN O
of ADP O
C.albicans NOUN O
initializes VERB O
apoptosis NOUN O
in ADP O
monocytes NOUN O
( PUNCT O
phagocytosis NOUN B-LF
induced VERB I-LF
cell NOUN I-LF
death NOUN I-LF
, PUNCT O
PICD PROPN B-AC
) PUNCT O
. PUNCT O
PICD PROPN B-AC
is AUX O
reduced VERB O
in ADP O
neonatal ADJ O
cord NOUN O
blood NOUN O
monocytes NOUN O
( PUNCT O
CBMO PROPN B-AC
) PUNCT O
. PUNCT O

HSR PROPN B-AC
, PUNCT O
Health NOUN B-LF
Star NOUN I-LF
Rating NOUN I-LF
; PUNCT O
NZ PROPN B-AC
, PUNCT O
New PROPN B-LF
Zealand PROPN I-LF
. PUNCT O

DN PROPN B-AC
, PUNCT O
dominant NOUN B-LF
- PUNCT I-LF
negative ADJ I-LF
; PUNCT O
EC PROPN B-AC
, PUNCT O
endothelial ADJ B-LF
cell NOUN I-LF
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
hpf NOUN B-AC
, PUNCT O
hours NOUN B-LF
post X I-LF
fertilization NOUN I-LF
; PUNCT O
HS PROPN B-AC
, PUNCT O
heat NOUN B-LF
shock NOUN I-LF
; PUNCT O
n.s X O
. PUNCT O
, PUNCT O
nonsignificant ADJ O
; PUNCT O
TF PROPN B-AC
, PUNCT O
transferrin NOUN B-LF
; PUNCT O
TRITC PROPN B-AC
, PUNCT O
tetramethylrhodamine NOUN B-LF
; PUNCT O
WISH NOUN B-AC
, PUNCT O
whole ADJ B-LF
- PUNCT I-LF
mount NOUN I-LF
in ADP I-LF
situ NOUN I-LF
hybridization NOUN I-LF

Fat NOUN B-LF
- PUNCT I-LF
free ADJ I-LF
mass NOUN I-LF
( PUNCT O
FFM PROPN B-AC
) PUNCT O
was AUX O
calculated VERB O
as ADP O
the DET O
difference NOUN O
between ADP O
body NOUN O
mass NOUN O
and CCONJ O
fat NOUN O
mass NOUN O
. PUNCT O

OPCE PROPN B-AC
, PUNCT O
overall ADJ B-LF
patient NOUN I-LF
- PUNCT I-LF
centered VERB I-LF
primary ADJ I-LF
care NOUN I-LF
experience NOUN I-LF
; PUNCT O
PC PROPN B-AC
, PUNCT O
primary ADJ B-LF
care NOUN I-LF
; PUNCT O
SRH PROPN B-AC
, PUNCT O
self NOUN B-LF
- PUNCT I-LF
rated VERB I-LF
health NOUN I-LF
. PUNCT O

Spinal ADJ B-LF
anesthesia NOUN I-LF
( PUNCT O
SA PROPN B-AC
) PUNCT O
is AUX O
a DET O
form NOUN O
of ADP O
regional ADJ O
anesthesia NOUN O
( PUNCT O
RA PROPN O
) PUNCT O
used VERB O
frequently ADV O
in ADP O
various ADJ O
lower ADJ O
abdominal ADJ O
, PUNCT O
orthopedic ADJ O
, PUNCT O
and CCONJ O
obstetric ADJ O
operations NOUN O
, PUNCT O
including VERB O
cesarean ADJ B-LF
delivery NOUN I-LF
( PUNCT O
CD NOUN B-AC
) PUNCT O
[ PUNCT O
1–4 NUM O
] PUNCT O
. PUNCT O

There PRON O
is VERB O
a DET O
high ADJ O
level NOUN O
of ADP O
variability NOUN O
in ADP O
the DET O
reported VERB O
mortality NOUN O
of ADP O
PARDS NOUN B-AC
[ X O
28,29 NUM O
] PUNCT O
ranging VERB O
from ADP O
11.3 NUM O
% NOUN O
in ADP O
a DET O
study NOUN O
including VERB O
children NOUN O
with ADP O
acute ADJ B-LF
lung NOUN I-LF
injury NOUN I-LF
( PUNCT O
ALI PROPN B-AC
) PUNCT O
[ X O
30 NUM O
] PUNCT O
to ADP O
76.5 NUM O
% NOUN O
in ADP O
a DET O
study NOUN O
of ADP O
children NOUN O
who PRON O
have AUX O
undergone VERB O
haematopoietic ADJ O
stem NOUN O
cell NOUN O
transplant NOUN O
[ X O
31 NUM O
] PUNCT O
. PUNCT O

The DET O
aim NOUN O
of ADP O
this DET O
study NOUN O
was AUX O
to PART O
investigate VERB O
whether SCONJ O
extracellular ADJ O
vesicles NOUN O
( PUNCT O
EVs NOUN B-AC
) PUNCT O
produced VERB O
by ADP O
human ADJ O
renal ADJ B-LF
proximal ADJ I-LF
tubular ADJ I-LF
epithelial ADJ I-LF
cells NOUN I-LF
( PUNCT O
RPTECs PROPN B-AC
) PUNCT O
may AUX O
induce VERB O
mesenchymal ADJ O
- PUNCT O
epithelial ADJ O
transition NOUN O
of ADP O
bone NOUN O
marrow NOUN O
- PUNCT O
derived VERB O
mesenchymal ADJ B-LF
stromal ADJ I-LF
cells NOUN I-LF
( PUNCT O
MSCs PROPN B-AC
) PUNCT O
. PUNCT O

Adaptation NOUN O
was AUX O
less ADV O
evident ADJ O
for ADP O
the DET O
pelvis NOUN O
at ADP O
HF PROPN B-AC
. PUNCT O
For ADP O
each DET O
participant NOUN O
and CCONJ O
condition NOUN O
, PUNCT O
the DET O
values NOUN O
of ADP O
the DET O
amplitude NOUN O
of ADP O
the DET O
head NOUN O
and CCONJ O
pelvis NOUN O
PP NOUN B-AC
displacements NOUN O
over ADP O
the DET O
successive ADJ O
cycles NOUN O
were AUX O
fitted VERB O
with ADP O
an DET O
exponential ADJ O
function NOUN O
and CCONJ O
the DET O
time NOUN O
constant NOUN O
and CCONJ O
adaptation NOUN B-LF
index NOUN I-LF
( PUNCT O
AI PROPN B-AC
) PUNCT O
estimated VERB O
. PUNCT O

The DET O
primers NOUN O
used VERB O
were AUX O
as SCONJ O
follows VERB O
: PUNCT O
GAPDH NOUN O
( PUNCT O
forward NOUN O
, PUNCT O
5’-ATC NUM O
ACC PROPN O
ATC PROPN O
TTC PROPN O
CAG PROPN O
GAG PROPN O
CGA-3 PROPN O
’ NOUN O
; PUNCT O
reverse NOUN O
, PUNCT O
5’-TTC NOUN O
TCC PROPN O
ATG PROPN O
GTG PROPN O
GTG PROPN O
AAG PROPN O
ACG-3 PROPN O
’ NOUN O
) PUNCT O
, PUNCT O
collagen NOUN B-LF
1A1 NOUN I-LF
( PUNCT O
COL1A1 NOUN B-AC
; PUNCT O
forward NOUN O
, PUNCT O
5’-AAG NOUN O
GTG PROPN O
CTG PROPN O
ATG PROPN O
GCT PROPN O
CTC PROPN O
CT-3 PROPN O
’ NOUN O
; PUNCT O
reverse NOUN O
, PUNCT O
5’-CTG NOUN O
GGA PROPN O
CCA PROPN O
CTT PROPN O
TCA PROPN O
CCC PROPN O
TT-3 PROPN O
’ NOUN O
) PUNCT O
, PUNCT O
collagen NOUN B-LF
1A2 NUM I-LF
( PUNCT O
COL1A2 PROPN B-AC
; PUNCT O
forward NOUN O
, PUNCT O
5’-GAA NOUN O
AGA PROPN O
AGG PROPN O
GCT PROPN O
TCG PROPN O
TGG PROPN O
TC-3 PROPN O
’ NOUN O
; PUNCT O
reverse NOUN O
, PUNCT O
5’-CAG NOUN O
CAG PROPN O
TAC PROPN O
CAG PROPN O
CCT PROPN O
CTC PROPN O
CA-3 PROPN O
’ NOUN O
) PUNCT O
, PUNCT O
and CCONJ O
collagen NOUN B-LF
3A1 NUM I-LF
( PUNCT O
COL3A1 NOUN B-AC
; PUNCT O
forward NOUN O
, PUNCT O
5’-AGG NOUN O
TCC PROPN O
TGC PROPN O
GGG PROPN O
TAA PROPN O
CAC PROPN O
T-3 PROPN O
’ NOUN O
; PUNCT O
reverse NOUN O
, PUNCT O
5’-ACT NUM O
TTC PROPN O
ACC PROPN O
CTT PROPN O
GAC PROPN O
ACC PROPN O
CTG-3 PROPN O
’ NOUN O
) PUNCT O
. PUNCT O

In ADP O
order NOUN O
to ADP O
address VERB O
this PRON O
, PUNCT O
we PRON O
solved VERB O
the DET O
structure NOUN O
of ADP O
the DET O
Lifeact PROPN O
– PUNCT O
F PROPN B-AC
- NOUN B-AC
actin NOUN B-AC
complex NOUN O
using VERB O
cryo NOUN B-AC
- NOUN B-AC
EM PROPN B-AC
. PUNCT O
The DET O
3.5 NUM O
Å NOUN O
structure NOUN O
reveals VERB O
that SCONJ O
Lifeact PROPN O
binds VERB O
to ADP O
2 NUM O
consecutive ADJ O
actin NOUN O
subunits NOUN O
of ADP O
the DET O
same ADJ O
strand NOUN O
of ADP O
the DET O
filament NOUN O
and CCONJ O
displaces VERB O
the DET O
DNase PROPN B-LF
I NOUN I-LF
– PUNCT I-LF
binding VERB I-LF
loop NOUN I-LF
( PUNCT O
D NOUN B-AC
- NOUN B-AC
loop NOUN B-AC
) PUNCT O
upon SCONJ O
binding VERB O
. PUNCT O

HV PROPN B-AC
- PUNCT O
Hepatic NOUN B-LF
vein NOUN I-LF
, PUNCT O
ICL PROPN B-AC
- PUNCT O
inferior ADJ B-LF
caudate ADJ I-LF
lobe NOUN I-LF
, PUNCT O
MML PROPN B-AC
- PUNCT O
middle ADJ B-LF
median ADJ I-LF
lobe NOUN I-LF
, PUNCT O
LML PROPN B-AC
- PUNCT O
left ADJ B-LF
median ADJ I-LF
lobe NOUN I-LF
, PUNCT O
LLL PROPN B-AC
- PUNCT O
left ADJ B-LF
lateral ADJ I-LF
lobe NOUN I-LF
, PUNCT O
PV NOUN B-AC
- PUNCT O
portal ADJ B-LF
vein NOUN I-LF
, PUNCT O
RIL PROPN B-AC
- PUNCT O
right ADJ B-LF
inferior ADJ I-LF
lobe NOUN I-LF
, PUNCT O
RML PROPN B-AC
- PUNCT O
right ADJ B-LF
median ADJ I-LF
lobe NOUN I-LF
, PUNCT O
RSL PROPN B-AC
- PUNCT O
right ADJ B-LF
superior ADJ I-LF
lobe NOUN I-LF
, PUNCT O
SCL NOUN B-AC
- PUNCT O
superior ADJ B-LF
caudate ADJ I-LF
lobe NOUN I-LF
. PUNCT O

AA PROPN B-AC
, PUNCT O
arachidonic ADJ B-LF
acid NOUN I-LF
; PUNCT O
AEA PROPN B-AC
, PUNCT O
N NOUN B-LF
- PUNCT I-LF
arachidonoylethanolamide NOUN I-LF
; PUNCT O
PEA PROPN B-AC
, PUNCT O
palmitoylethanolamide NOUN B-LF
. PUNCT O

SNP NOUN B-AC
, PUNCT O
single ADJ B-LF
nucleotide NOUN I-LF
polymorphism NOUN I-LF
; PUNCT O
UTR NOUN B-AC
, PUNCT O
untranslated VERB B-LF
region NOUN I-LF
. PUNCT O

We PRON O
employed VERB O
a DET O
monoclonal ADJ B-LF
antibody NOUN I-LF
( PUNCT O
mAb NOUN B-AC
659 NUM O
) PUNCT O
specific ADJ O
for ADP O
the DET O
unique ADJ O
and CCONJ O
intact ADJ O
thrombin NOUN O
- PUNCT O
sensitive ADJ O
site NOUN O
in ADP O
OPN PROPN B-AC
using VERB O
an DET O
inhibition NOUN O
ELISA PROPN B-AC
. PUNCT O
We PRON O
found VERB O
significantly ADV O
higher ADJ O
levels NOUN O
of ADP O
OPN PROPN B-AC
in ADP O
33 NUM O
cervical ADJ O
cancer NOUN O
patients NOUN O
in ADP O
both CCONJ O
the DET O
plasma NOUN O
( PUNCT O
mean NOUN O
+ ADJ O
/- ADJ O
SD NOUN O
, PUNCT O
612 NUM O
+ ADJ O
/- ADJ O
106 NUM O
ng NOUN O
/ NOUN O
mL NOUN O
) PUNCT O
and CCONJ O
serum NOUN O
( PUNCT O
424 NUM O
+ ADJ O
/- ADJ O
121 NUM O
ng NOUN O
/ NOUN O
mL NOUN O
) PUNCT O
compared VERB O
to ADP O
healthy ADJ O
subjects NOUN O
[ PUNCT O
409 NUM O
+ ADJ O
/- ADJ O
56 NUM O
ng NOUN O
/ NOUN O
mL NOUN O
, PUNCT O
from ADP O
31 NUM O
plasma NOUN O
samples NOUN O
( PUNCT O
P NOUN O
< ADP O
0.0001 NUM O
) PUNCT O
, PUNCT O
and CCONJ O
314 NUM O
+ ADJ O
/- ADJ O
98 NUM O
ng NOUN O
/ NOUN O
mL NOUN O
, PUNCT O
from ADP O
32 NUM O
serum NOUN O
samples NOUN O
( PUNCT O
P NOUN O
= SYM O
0.0002 NUM O
) PUNCT O
, PUNCT O
respectively ADV O
] PUNCT O
. PUNCT O

Adverse ADJ B-LF
events NOUN I-LF
( PUNCT O
AEs NOUN B-AC
) PUNCT O
and CCONJ O
serious ADJ B-LF
adverse ADJ I-LF
events NOUN I-LF
( PUNCT O
SAEs NOUN B-AC
) PUNCT O
are AUX O
shown VERB O
, PUNCT O
regardless ADV O
of ADP O
study NOUN O
drug NOUN O
relationship NOUN O
, PUNCT O
by ADP O
preferred VERB O
term NOUN O
and CCONJ O
treatment NOUN O
group NOUN O
. PUNCT O

WT PROPN B-AC
, PUNCT O
wild NOUN B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

Both CCONJ O
healthy ADJ O
volunteers NOUN O
and CCONJ O
trauma NOUN O
patients NOUN O
were AUX O
enrolled VERB O
and CCONJ O
consented VERB O
under ADP O
an DET O
approved ADJ O
Virginia PROPN B-LF
Commonwealth PROPN I-LF
University PROPN I-LF
( PUNCT O
VCU PROPN B-AC
) PUNCT O
IRB PROPN B-AC
protocol NOUN O
. PUNCT O

ITT PROPN O
, PUNCT O
intention NOUN O
to PART O
treat VERB O
; PUNCT O
RE PROPN B-AC
, PUNCT O
reinforced VERB B-LF
education NOUN I-LF
; PUNCT O
SE PROPN B-AC
, PUNCT O
standard ADJ B-LF
education NOUN I-LF
; PUNCT O
BP PROPN B-AC
, PUNCT O
bowel NOUN B-LF
preparation NOUN I-LF
; PUNCT O
RCT NOUN B-AC
, PUNCT O
randomized ADJ B-LF
controlled ADJ I-LF
trial NOUN I-LF
; PUNCT O
SMS NOUN B-AC
, PUNCT O
short ADJ B-LF
message NOUN I-LF
service NOUN I-LF
; PUNCT O
NR NOUN O
, PUNCT O
not PART O
reported VERB O

Based VERB O
on ADP O
cell NOUN O
cycle NOUN O
– PUNCT O
dependent ADJ O
degradation NOUN O
of ADP O
chromatin NOUN B-LF
licensing NOUN I-LF
and CCONJ I-LF
DNA NOUN I-LF
replication NOUN I-LF
factor NOUN I-LF
1 NUM I-LF
( PUNCT O
CDT1 PROPN B-AC
) PUNCT O
and CCONJ O
geminin NOUN B-LF
DNA NOUN I-LF
replication NOUN I-LF
inhibitor NOUN I-LF
( PUNCT O
GEMININ PROPN B-AC
) PUNCT O
proteins NOUN O
, PUNCT O
cells NOUN O
show VERB O
no DET O
color NOUN O
in ADP O
early ADJ O
G1 PROPN O
, PUNCT O
red ADJ O
in ADP O
mid ADJ O
/ SYM O
late ADJ O
G1 PROPN O
, PUNCT O
and CCONJ O
green NOUN O
in ADP O
S NOUN O
/ SYM O
G2 NOUN O
/ SYM O
M NOUN O
( PUNCT O
S1A PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

All DET O
single ADJ B-LF
nucleotide NOUN I-LF
variants NOUN I-LF
( PUNCT O
SNVs NOUN B-AC
) PUNCT O
and CCONJ O
insertions NOUN O
and CCONJ O
deletions NOUN O
( PUNCT O
InDels NOUN B-AC
) PUNCT O
detected VERB O
through ADP O
bioinformatics NOUN O
analysis NOUN O
underwent VERB O
visual ADJ O
inspection NOUN O
using VERB O
the DET O
IGV PROPN B-AC
for ADP O
confirmation NOUN O
. PUNCT O

Secondly ADV O
, PUNCT O
we PRON O
employed VERB O
a DET O
correlation NOUN B-LF
- PUNCT I-LF
based VERB I-LF
feature NOUN I-LF
selection NOUN I-LF
( PUNCT O
CFS PROPN B-AC
) PUNCT O
algorithm NOUN O
[ PUNCT O
16]-a NUM O
WEKA PROPN O
[ PUNCT O
17 NUM O
] X O
tool NOUN O
. PUNCT O

Immunostained ADJ O
serial ADJ O
retinal ADJ O
sections NOUN O
were AUX O
each PRON O
divided VERB O
into ADP O
four NUM O
regions NOUN O
relative ADJ O
to ADP O
the DET O
optic ADJ O
nerve NOUN O
and CCONJ O
were AUX O
designated VERB O
far ADV B-LF
superior ADJ I-LF
( PUNCT O
FAR PROPN B-AC
SUP PROPN B-AC
) PUNCT O
, PUNCT O
superior ADJ B-LF
( PUNCT O
SUP PROPN B-AC
) PUNCT O
, PUNCT O
superior ADJ B-LF
optic ADJ I-LF
nerve NOUN I-LF
( PUNCT O
SUP PROPN B-AC
ON PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
inferior ADJ B-LF
optic ADJ I-LF
nerve NOUN I-LF
( PUNCT O
INF PROPN B-AC
ON PROPN B-AC
) PUNCT O
. PUNCT O
Each DET O
region NOUN O
was AUX O
assigned VERB O
a DET O
percent NOUN O
transduction NOUN O
score NOUN O
by ADP O
an DET O
independent ADJ O
observer NOUN O
that PRON O
was AUX O
based VERB O
on ADP O
the DET O
number NOUN O
of ADP O
GFP PROPN B-AC
- PUNCT O
positive ADJ O
cells NOUN O
within ADP O
the DET O
region NOUN O
. PUNCT O

Semi ADJ O
- PUNCT O
structured ADJ O
in ADP B-LF
- PUNCT I-LF
depth NOUN I-LF
interview NOUN I-LF
( PUNCT O
IDI NOUN B-AC
) PUNCT O
guiding VERB O
questions NOUN O
were AUX O
used VERB O
. PUNCT O

HRVT2 PROPN B-AC
- PUNCT B-AC
HFP PROPN B-AC
& CCONJ B-AC
HRVT2 PROPN B-AC
- PUNCT B-AC
HFP PROPN B-AC
- PUNCT B-AC
RSA PROPN B-AC
= VERB O
heart NOUN O
rate NOUN O
variability NOUN O
thresholds NOUN O
as SCONJ O
determined VERB O
from ADP O
the DET O
high ADJ O
frequency NOUN O
power NOUN O
and CCONJ O
from ADP O
the DET O
high ADJ O
frequency NOUN O
power NOUN O
component NOUN O
related VERB O
to ADP O
respiratory ADJ B-LF
sinus NOUN I-LF
arrhythmia NOUN I-LF
, PUNCT O
respectively ADV O
; PUNCT O
VT2 PROPN O
= VERB O
second ADJ O
Ventilatory ADJ O
threshold NOUN O
. PUNCT O

The DET O
aim NOUN O
of ADP O
the DET O
present ADJ O
randomised ADJ B-LF
controlled ADJ I-LF
trial NOUN I-LF
( PUNCT O
RCT PROPN B-AC
) PUNCT O
was AUX O
to PART O
determine VERB O
the DET O
impact NOUN O
of ADP O
such DET O
a DET O
patient NOUN O
- PUNCT O
centred VERB O
approach NOUN O
in ADP O
CMR PROPN B-AC
on ADP O
patients NOUN O
' PART O
lives NOUN O
, PUNCT O
including VERB O
HR NOUN B-AC
- PUNCT B-AC
QoL NOUN B-AC
and CCONJ O
health NOUN O
problems NOUN O
. PUNCT O

It PRON O
is AUX O
common ADJ O
for ADP O
chiropractors NOUN O
to PART O
recommend VERB O
“ PUNCT O
maintenance NOUN B-LF
care NOUN I-LF
( PUNCT O
MC PROPN B-AC
) PUNCT O
” PUNCT O
, PUNCT O
i.e. X O
preventive ADJ O
consultations NOUN O
/ SYM O
visits NOUN O
for ADP O
recurrent ADJ O
and CCONJ O
persistent ADJ O
musculoskeletal ADJ O
pain NOUN O
and CCONJ O
dysfunction NOUN O
[ PUNCT O
16 NUM O
] PUNCT O
. PUNCT O

CFT NOUN B-AC
, PUNCT O
clot NOUN B-LF
formation NOUN I-LF
time NOUN I-LF
; PUNCT O
CT PROPN B-AC
, PUNCT O
clotting NOUN B-LF
time NOUN I-LF
; PUNCT O
MCF PROPN B-AC
, PUNCT O
maximum ADJ B-LF
clot NOUN I-LF
firmness NOUN I-LF
; PUNCT O
ML NOUN B-AC
, PUNCT O
maximum ADJ B-LF
lysis NOUN I-LF

COPD NOUN B-AC
, PUNCT O
chronic ADJ B-LF
obstructive ADJ I-LF
pulmonary ADJ I-LF
disease NOUN I-LF
. PUNCT O

A DET O
hallmark NOUN O
of ADP O
such ADJ O
proteins NOUN O
is AUX O
the DET O
presence NOUN O
of ADP O
a DET O
130 NUM O
- PUNCT O
aa NOUN O
Su(var NOUN B-LF
) PUNCT I-LF
, PUNCT I-LF
Enhancer NOUN I-LF
of ADP I-LF
zeste NOUN I-LF
, PUNCT I-LF
Trithorax NOUN I-LF
( PUNCT O
SET PROPN B-AC
) PUNCT O
domain NOUN O
. PUNCT O

AF PROPN B-AC
, PUNCT O
atrial ADJ B-LF
fibrillation NOUN I-LF
; PUNCT O
KMD PROPN B-AC
, PUNCT O
Kardia PROPN B-LF
Mobile PROPN I-LF
Device PROPN I-LF
; PUNCT O
SLECG PROPN B-AC
, PUNCT O
single ADJ B-LF
- PUNCT I-LF
lead NOUN I-LF
ECG NOUN I-LF
. PUNCT O

Schisandra PROPN B-LF
chinensis NOUN I-LF
extracts NOUN I-LF
( PUNCT O
SEs NOUN B-AC
) PUNCT O
have AUX O
traditionally ADV O
been AUX O
used VERB O
as ADP O
an DET O
oriental ADJ O
medicine NOUN O
for ADP O
the DET O
treatment NOUN O
of ADP O
various ADJ O
human ADJ O
diseases NOUN O
, PUNCT O
however ADV O
, PUNCT O
their PRON O
further ADJ O
application NOUN O
in ADP O
the DET O
biocontrol NOUN O
of ADP O
plant NOUN O
disease NOUN O
remains VERB O
poorly ADV O
understood VERB O
. PUNCT O

The DET O
cDNA NOUN O
encoding VERB O
the DET O
chimp NOUN O
AR PROPN B-AC
LBD PROPN B-AC
( PUNCT O
residues NOUN O
663–919 NUM O
— PUNCT O
human ADJ O
numbering NOUN O
) PUNCT O
, PUNCT O
which PRON O
displays VERB O
100 NUM O
% NOUN O
identity NOUN O
to ADP O
the DET O
human ADJ O
form NOUN O
in ADP O
protein NOUN O
sequence NOUN O
, PUNCT O
was AUX O
cloned VERB O
into ADP O
a DET O
modified VERB O
pGEX-2 PROPN O
T PROPN O
vector NOUN O
( PUNCT O
Amersham PROPN O
Biosciences PROPN O
, PUNCT O
Piscataway PROPN O
, PUNCT O
New PROPN O
Jersey PROPN O
, PUNCT O
United PROPN O
States PROPN O
) PUNCT O
and CCONJ O
expressed VERB O
as ADP O
glutathione NOUN B-LF
S PROPN I-LF
- PROPN I-LF
transferase NOUN I-LF
( PUNCT O
GST PROPN B-AC
) PUNCT O
fusion NOUN O
protein NOUN O
in ADP O
the DET O
E. PROPN O
coli PROPN O
strain NOUN O
BL21 PROPN O
( PUNCT O
DE3 PROPN O
) PUNCT O
STAR PROPN O
in ADP O
the DET O
presence NOUN O
of ADP O
10 NUM O
μM NOUN O
DHT PROPN B-AC
. PUNCT O
Induction NOUN O
was AUX O
carried VERB O
out ADP O
with ADP O
30 NUM O
μM NOUN O
IPTG PROPN O
at ADP O
17 NUM O
° NOUN O
C NOUN O
for ADP O
16–18 NUM O
h. PUNCT O

Abbreviation NOUN O
: PUNCT O
NMVOC PROPN B-AC
, PUNCT O
non ADJ B-LF
- ADJ I-LF
methane ADJ I-LF
volatile ADJ I-LF
organic ADJ I-LF
compound NOUN I-LF
. PUNCT O

The DET O
terms NOUN O
used VERB O
were AUX O
“ PUNCT O
Killer PROPN B-LF
Immunoglobulin PROPN I-LF
- PUNCT I-LF
like ADJ I-LF
Receptor PROPN I-LF
” PUNCT O
, PUNCT O
‘ PUNCT O
KIR PROPN B-AC
” PUNCT O
, PUNCT O
“ PUNCT O
HIV PROPN B-AC
” PUNCT O
, PUNCT O
“ PUNCT O
Human PROPN B-LF
Immunodeficiency PROPN I-LF
Virus PROPN I-LF
” PUNCT O
, PUNCT O
“ PUNCT O
HESN PROPN B-AC
” PUNCT O
“ PUNCT O
HIV PROPN B-AC
- PUNCT O
exposed VERB O
seronegative NOUN O
” PUNCT O
as ADP O
medical ADJ O
subject NOUN O
headings NOUN O
and CCONJ O
text NOUN O
, PUNCT O
without ADP O
language NOUN O
restrictions NOUN O
. PUNCT O

The DET O
method NOUN O
of ADP O
creating VERB O
cancer NOUN B-LF
tissue NOUN I-LF
originated VERB I-LF
spheroid NOUN I-LF
cells NOUN I-LF
( PUNCT O
CTOS PROPN B-AC
) PUNCT O
is AUX O
the DET O
most ADV O
powerful ADJ O
technology NOUN O
to PART O
evaluate VERB O
such DET O
a DET O
mouse NOUN O
model NOUN O
[ PUNCT O
47 NUM O
] PUNCT O
. PUNCT O

Only ADV O
two NUM O
proteins NOUN O
, PUNCT O
S100 NOUN B-LF
calcium NOUN I-LF
binding VERB I-LF
protein NOUN I-LF
A9 PROPN I-LF
( PUNCT O
S100a9 PROPN B-AC
) PUNCT O
and CCONJ O
transthyretin NOUN B-LF
( PUNCT O
Ttr NOUN B-AC
) PUNCT O
which PRON O
are AUX O
involved ADJ O
in ADP O
calcium NOUN O
signaling NOUN O
and CCONJ O
the DET O
extracellular ADJ O
region NOUN O
, PUNCT O
respectively ADV O
, PUNCT O
were AUX O
commonly ADV O
regulated VERB O
by ADP O
three NUM O
different ADJ O
treatments NOUN O
. PUNCT O

In ADP O
contrast NOUN O
, PUNCT O
the DET O
hypothesis NOUN O
of ADP O
an DET O
unliganded ADJ O
AncNR PROPN B-AC
can AUX O
explain VERB O
the DET O
structure NOUN O
- PUNCT O
function NOUN O
relations NOUN O
of ADP O
only ADV O
a DET O
single ADJ O
NR NOUN O
as ADP O
due ADJ O
to PART O
descent NOUN O
from ADP O
the DET O
ancestral ADJ B-LF
NR NOUN I-LF
; PUNCT O
it PRON O
requires VERB O
the DET O
ancestral ADJ O
basis NOUN O
for ADP O
ligand NOUN O
- PUNCT O
independent ADJ O
activity NOUN O
to PART O
have AUX O
been AUX O
independently ADV O
lost VERB O
and CCONJ O
replaced VERB O
with ADP O
different ADJ O
underlying VERB O
mechanisms NOUN O
in ADP O
all DET O
other ADJ O
lineages NOUN O
of ADP O
ligand NOUN O
- PUNCT O
independent ADJ O
receptors NOUN O
and CCONJ O
the DET O
shared VERB O
mechanisms NOUN O
for ADP O
ligand NOUN O
- PUNCT O
dependent ADJ O
activation NOUN O
to PART O
have AUX O
been AUX O
gained VERB O
independently ADV O
in ADP O
the DET O
many ADJ O
lineages NOUN O
of ADP O
liganded ADJ O
receptors NOUN O
. PUNCT O

The DET B-AC
fracture NOUN O
is AUX O
viewed VERB O
as ADP O
a DET O
tube NOUN O
with ADP O
a DET O
rectangular ADJ O
cross NOUN O
- PUNCT O
section NOUN O
, PUNCT O
and CCONJ O
its PRON O
hfr NOUN B-AC
is AUX O
calculated VERB O
by ADP O
[ PUNCT O
26 NUM O
] PUNCT O
: PUNCT O
hfr NOUN B-AC
= X O
Nufr⋅λWdfr(25 NOUN O
) PUNCT O
where SCONJ O
dfr NOUN B-AC
is AUX O
the DET O
equivalent ADJ O
diameter NOUN O
of ADP O
the DET O
fracture NOUN O
tube NOUN O
, PUNCT O
and CCONJ O
Nufr PROPN O
is AUX O
the DET O
Nusselt PROPN O
number NOUN O
which PRON O
is AUX O
calculated VERB O
by ADP O
the DET O
Dittus PROPN O
- PUNCT O
Boelter PROPN O
Equation NOUN O
[ PUNCT O
26 NUM O
] PUNCT O
: PUNCT O
Nufr=0.023Refr0.8Pr0.3(26 NUM O
) PUNCT O
where SCONJ O
Refr X B-AC
is AUX O
the DET O
Reynolds PROPN B-LF
number NOUN I-LF
of ADP I-LF
flow NOUN I-LF
in ADP I-LF
the DET I-LF
fracture NOUN I-LF
, PUNCT O
which PRON O
is AUX O
given VERB O
by ADP O
: PUNCT O
Refr X B-AC
= X O
uwdfrνw(27 X O
) PUNCT O

An DET O
incremental ADJ O
cost NOUN O
- PUNCT O
utility NOUN O
analysis NOUN O
using VERB O
a DET O
Markov PROPN O
model NOUN O
was AUX O
performed VERB O
comparing VERB O
guaiac PROPN O
- PUNCT O
based VERB O
fecal ADJ B-LF
occult ADJ I-LF
blood NOUN I-LF
test NOUN I-LF
( PUNCT O
FOBT PROPN B-AC
) PUNCT O
or CCONJ O
fecal ADJ B-LF
immunochemical ADJ I-LF
test NOUN I-LF
( PUNCT O
FIT PROPN B-AC
) PUNCT O
annually ADV O
, PUNCT O
fecal ADJ O
DNA NOUN O
every DET O
3 NUM O
years NOUN O
, PUNCT O
flexible ADJ O
sigmoidoscopy NOUN O
or CCONJ O
computed VERB O
tomographic ADJ O
colonography NOUN O
every DET O
5 NUM O
years NOUN O
, PUNCT O
and CCONJ O
colonoscopy NOUN O
every DET O
10 NUM O
years NOUN O
. PUNCT O

Baseline ADJ O
clinical ADJ O
variables NOUN O
, PUNCT O
including VERB O
age NOUN O
, PUNCT O
gender NOUN O
, PUNCT O
CF PROPN B-AC
genotype NOUN O
, PUNCT O
pancreatic ADJ O
insufficiency NOUN O
, PUNCT O
CF PROPN B-AC
- PUNCT O
related VERB O
diabetes NOUN O
and/or CCONJ O
liver NOUN O
disease NOUN O
, PUNCT O
body NOUN B-LF
- PUNCT I-LF
mass NOUN I-LF
- PUNCT I-LF
index NOUN I-LF
( PUNCT O
BMI PROPN B-AC
) PUNCT O
at ADP O
the DET O
time NOUN O
of ADP O
the DET O
recorded VERB O
forced VERB B-LF
expiratory ADJ I-LF
volume NOUN I-LF
in ADP I-LF
the DET I-LF
first ADJ I-LF
second ADJ I-LF
( PUNCT O
FEV1 NOUN B-AC
[ X O
% NOUN O
predicted VERB O
] PUNCT O
) PUNCT O
in ADP O
the DET O
calendar NOUN O
year NOUN O
of ADP O
sputum NOUN O
collection NOUN O
, PUNCT O
the DET O
aforementioned ADJ O
FEV1 NOUN B-AC
% NOUN O
predicted VERB O
, PUNCT O
co NOUN O
- PUNCT O
pathogens NOUN O
( PUNCT O
Burkholderia PROPN O
cepacia PROPN O
complex NOUN O
, PUNCT O
Staphylococcus PROPN O
aureus NOUN O
, PUNCT O
Achromobacter PROPN O
and CCONJ O
Aspergillus PROPN O
species NOUN O
) PUNCT O
, PUNCT O
maintenance NOUN O
treatment NOUN O
( PUNCT O
azithromycin NOUN O
, PUNCT O
inhaled ADJ O
antibiotics NOUN O
and/or CCONJ O
mucolytic ADJ O
therapies NOUN O
) PUNCT O
, PUNCT O
as SCONJ O
well ADV O
as SCONJ O
treatment NOUN O
episodes NOUN O
requiring VERB O
intravenous ADJ B-LF
( PUNCT O
IV PROPN B-AC
) PUNCT O
antibiotics NOUN O
( PUNCT O
number NOUN O
of ADP O
episodes NOUN O
and CCONJ O
days NOUN O
of ADP O
hospitalisation NOUN O
) PUNCT O
and CCONJ O
the DET O
number NOUN O
of ADP O
outpatient NOUN O
visits NOUN O
in ADP O
the DET O
12 NUM O
- PUNCT O
months NOUN O
before ADP O
sputum NOUN O
collection NOUN O
were AUX O
recorded VERB O
as SCONJ O
described VERB O
previously ADV O
[ X O
13 NUM O
] PUNCT O
. PUNCT O

FEV1 PROPN B-AC
– PUNCT O
Forced VERB O
Expiratory ADJ O
Volume NOUN O
in ADP O
1st ADJ O
Second NOUN O
; PUNCT O
FVC PROPN B-AC
– PUNCT O
Forced VERB B-LF
Vital ADJ I-LF
Capacity NOUN I-LF
; PUNCT O
REE PROPN B-AC
– PUNCT O
Resting VERB B-LF
Energy NOUN I-LF
Expenditure NOUN I-LF
; PUNCT O
Kcal NOUN O
– PUNCT O
Kilocalories NOUN O
; PUNCT O
FFM PROPN B-AC
– PUNCT O
Fat NOUN B-LF
Free ADJ I-LF
Mass. NOUN I-LF

AD PROPN B-AC
, PUNCT O
aggregate ADJ B-LF
data NOUN I-LF
; PUNCT O
HR PROPN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT O
IPD PROPN B-AC
, PUNCT O
individual ADJ B-LF
participant NOUN I-LF
data NOUN I-LF
. PUNCT O

ADAR1 NOUN B-AC
, PUNCT O
adenosine NOUN B-LF
deaminase NOUN I-LF
acting VERB I-LF
on ADP I-LF
RNA NOUN I-LF
1 NUM I-LF
; PUNCT O
ADAR1KO PROPN B-AC
, PUNCT O
fully ADV B-LF
ADAR1 NOUN I-LF
- PUNCT I-LF
deficient ADJ I-LF
; PUNCT O
FL PROPN B-AC
- PUNCT B-AC
MAVS PROPN B-AC
, PUNCT O
full ADJ B-LF
- PUNCT I-LF
length NOUN I-LF
MAVS PROPN I-LF
; PUNCT O
IFN PROPN B-AC
, PUNCT O
interferon NOUN B-LF
; PUNCT O
IRF3 NOUN B-AC
, PUNCT O
IFN PROPN B-LF
regulatory ADJ I-LF
transcription NOUN I-LF
factor NOUN I-LF
3 NUM I-LF
; PUNCT O
MAVS PROPN B-AC
, PUNCT O
mitochondrial ADJ B-LF
antiviral ADJ I-LF
signaling NOUN I-LF
protein NOUN I-LF
; PUNCT O
MeV PROPN B-AC
, PUNCT O
measles NOUN B-LF
virus NOUN I-LF
; PUNCT O
MOI PROPN B-AC
, PUNCT O
multiplicity NOUN B-LF
of ADP I-LF
infection NOUN I-LF
; PUNCT O
N PROPN O
, PUNCT O
nucleoprotein NOUN O
; PUNCT O
p150KO PROPN B-AC
, PUNCT O
selectively ADV B-LF
ADAR1p150 NOUN I-LF
- PUNCT I-LF
deficient ADJ I-LF
; PUNCT O
pIRF3 PROPN O
, PUNCT O
phospho NOUN O
- PUNCT O
IRF3 NOUN B-AC
; PUNCT O
PKR NOUN B-AC
, PUNCT O
protein NOUN B-LF
kinase NOUN I-LF
R PROPN I-LF
; PUNCT O
pPKR PROPN O
, PUNCT O
phospho NOUN O
- PUNCT O
PKR NOUN B-AC
; PUNCT O
UI PROPN O
, PUNCT O
uninfected ADJ O
. PUNCT O

It PRON O
would AUX O
be AUX O
interesting ADJ O
to PART O
see VERB O
if SCONJ O
this DET O
low ADJ O
intrinsic ADJ O
DAP PROPN B-AC
- PUNCT O
PG NOUN B-AC
hydrolyzing NOUN O
activity NOUN O
could AUX O
be AUX O
stimulated VERB O
by ADP O
another DET O
hemolymph NOUN O
protein(s NOUN O
) PUNCT O
that PRON O
could AUX O
associate VERB O
with ADP O
PGRP NOUN B-AC
- PUNCT O
SA PROPN O
, PUNCT O
such ADJ O
as ADP O
Gram NOUN B-LF
- PUNCT I-LF
negative ADJ I-LF
bacteria NOUN I-LF
- PUNCT I-LF
binding VERB I-LF
protein NOUN I-LF
1 NUM I-LF
( PUNCT O
GNBP1 PROPN B-AC
) PUNCT O
( PUNCT O
see VERB O
below ADV O
) PUNCT O
. PUNCT O

The DET O
FAST PROPN O
- PUNCT O
MI PROPN O
Tunisia PROPN O
registry NOUN O
was AUX O
set VERB O
up ADP O
through ADP O
a DET O
close ADJ O
collaboration NOUN O
between ADP O
the DET O
Tunisian ADJ B-LF
Society PROPN I-LF
of ADP I-LF
Cardiology PROPN I-LF
and CCONJ I-LF
Cardiovascular PROPN I-LF
Surgery PROPN I-LF
( PUNCT O
TSCCS PROPN B-AC
) PUNCT O
and CCONJ O
the DET O
French PROPN B-LF
Society PROPN I-LF
of ADP I-LF
Cardiology PROPN I-LF
( PUNCT O
FSC PROPN B-AC
) PUNCT O
. PUNCT O
Participation NOUN O
in ADP O
this DET O
first ADJ O
Tunisian ADJ O
registry NOUN O
was AUX O
proposed VERB O
to ADP O
all DET O
Tunisian ADJ O
hospitals NOUN O
( PUNCT O
in ADP O
both CCONJ O
public ADJ O
and CCONJ O
private ADJ O
sectors NOUN O
) PUNCT O
. PUNCT O

As SCONJ O
CPXV203 PROPN O
N146 PROPN O
is AUX O
not PART O
solvent NOUN O
- PUNCT O
accessible ADJ O
, PUNCT O
its PRON O
lack NOUN O
of ADP O
glycosylation NOUN O
( PUNCT O
mass NOUN O
spec NOUN O
and CCONJ O
PNGase PROPN O
treatment NOUN O
, PUNCT O
unpublished ADJ O
data NOUN O
) PUNCT O
is AUX O
not PART O
surprising ADJ O
. PUNCT O
( PUNCT O
B NOUN O
) PUNCT O
Structure NOUN O
- PUNCT O
based VERB O
alignment NOUN O
( PUNCT O
Dali PROPN O
server NOUN O
) PUNCT O
of ADP O
CPXV203 PROPN O
with ADP O
various ADJ O
poxvirus NOUN O
CKBPs NOUN B-AC
: PUNCT O
ectromelia NOUN O
virus NOUN O
( PUNCT O
ECTV PROPN O
) PUNCT O
CrmD PROPN O
C PROPN O
- PUNCT O
terminal ADJ O
domain NOUN O
( PUNCT O
CrmD PROPN O
- PUNCT O
CTD PROPN O
) PUNCT O
[ PUNCT O
1 NUM O
] PUNCT O
, PUNCT O
vaccinia NOUN O
virus NOUN O
( PUNCT O
VACV PROPN O
) PUNCT O
A41 PROPN O
[ PUNCT O
2 NUM O
] PUNCT O
, PUNCT O
ECTV PROPN O
vCCI NOUN O
[ PUNCT O
3 NUM O
] PUNCT O
, PUNCT O
rabbitpox NOUN O
( PUNCT O
RPV PROPN O
) PUNCT O
vCCI NOUN O
[ PUNCT O
4 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
cowpox NOUN B-LF
virus NOUN I-LF
( PUNCT O
CPXV PROPN B-AC
) PUNCT O
vCCI NOUN O
[ PUNCT O
5 NUM O
] PUNCT O
. PUNCT O

Extracted VERB B-LF
ion NOUN I-LF
chromatograms NOUN I-LF
( PUNCT O
EICs NOUN B-AC
) PUNCT O
were AUX O
produced VERB O
for ADP O
each DET O
standard NOUN O
using VERB O
the DET O
ion NOUN O
series NOUN O
indicated VERB O
in ADP O
Table NOUN O
A NOUN O
in ADP O
S2 PROPN O
File PROPN O
and CCONJ O
a DET O
+ NOUN O
/- NOUN O
0.1 NUM O
m NOUN B-AC
/ SYM B-AC
z NOUN B-AC
tolerance NOUN O
. PUNCT O

Postpartum ADJ O
depressive ADJ O
symptom NOUN O
was AUX O
measured VERB O
using VERB O
the DET O
Edinburg PROPN B-LF
Postnatal PROPN I-LF
Depression PROPN I-LF
Scale PROPN I-LF
( PUNCT O
EPDS PROPN B-AC
) PUNCT O
[ PUNCT O
33 NUM O
] PUNCT O
. PUNCT O

KOR PROPN B-AC
left VERB B-LF
, PUNCT I-LF
KOR PROPN I-LF
activity NOUN I-LF
remained VERB I-LF
; PUNCT O
DOR PROPN B-AC
left VERB B-LF
, PUNCT I-LF
DOR PROPN I-LF
activity NOUN I-LF
remained VERB I-LF
; PUNCT O
MOR PROPN B-AC
left VERB B-LF
, PUNCT I-LF
MOR PROPN I-LF
activity NOUN I-LF
remained VERB I-LF
. PUNCT O

By ADP O
subtracting VERB O
the DET O
risk NOUN O
attributable ADJ O
to ADP O
main ADJ O
effects NOUN O
only ADV O
from ADP O
the DET O
total ADJ O
risk NOUN O
, PUNCT O
we PRON O
isolated VERB O
the DET O
absolute ADJ B-LF
risk NOUN I-LF
due ADJ I-LF
to ADP I-LF
interaction NOUN I-LF
( PUNCT O
ARI NOUN B-AC
) PUNCT O
in ADP O
the DET O
additive ADJ O
scale NOUN O
for ADP O
each DET O
intersectional ADJ O
stratum NOUN O
. PUNCT O

Serum ADJ O
β2 NOUN O
-microglobulin NOUN O
levels NOUN O
in ADP O
Coronavirus PROPN B-LF
Disease PROPN I-LF
2019 NUM I-LF
( PUNCT O
Covid-19 PROPN B-AC
): PUNCT O
another DET O
prognosticator NOUN O
of ADP O
disease NOUN O
severity NOUN O
? PUNCT O

At ADP O
the DET O
same ADJ O
time NOUN O
, PUNCT O
the DET O
uncertainty NOUN O
in ADP O
these DET O
projections NOUN O
is AUX O
accounted VERB O
for ADP O
in ADP O
the DET O
calculation NOUN O
of ADP O
standard ADJ B-LF
errors NOUN I-LF
( PUNCT O
SEs NOUN B-AC
) PUNCT O
and CCONJ O
test NOUN O
statistics NOUN O
. PUNCT O

Diagnostic ADJ O
imaging NOUN O
studies NOUN O
included VERB O
chest NOUN B-LF
radiograph NOUN I-LF
( PUNCT O
CR NOUN B-AC
) PUNCT O
and CCONJ O
spiral ADJ O
CT NOUN B-AC
. PUNCT O

Acute ADJ B-LF
respiratory ADJ I-LF
distress NOUN I-LF
syndrome NOUN I-LF
( PUNCT O
ARDS PROPN B-AC
) PUNCT O
is AUX O
a DET O
devastating ADJ O
clinical ADJ O
syndrome NOUN O
with ADP O
high ADJ O
mortality NOUN O
( PUNCT O
about ADV O
30%-50%)[1 NUM O
] PUNCT O
. PUNCT O

The DET O
Australian PROPN B-LF
Trial PROPN I-LF
in ADP I-LF
Acute PROPN I-LF
Hepatitis PROPN I-LF
C PROPN I-LF
( PUNCT O
ATAHC PROPN B-AC
) PUNCT O
was AUX O
a DET O
prospective ADJ O
, PUNCT O
non ADJ O
- ADJ O
randomised ADJ O
trial NOUN O
of ADP O
the DET O
natural ADJ O
history NOUN O
and CCONJ O
treatment NOUN O
of ADP O
recently ADV O
acquired VERB O
HCV PROPN B-AC
infection NOUN O
, PUNCT O
and CCONJ O
predominantly ADV O
recruited VERB O
PWID PROPN B-AC
[ PUNCT O
5 NUM O
] PUNCT O
. PUNCT O

This DET O
study NOUN O
is AUX O
reported VERB O
as SCONJ O
per ADP O
the DET O
reporting NOUN B-LF
of ADP I-LF
studies NOUN I-LF
conducted VERB I-LF
using VERB I-LF
observational ADJ I-LF
routinely ADV I-LF
collected VERB I-LF
health NOUN I-LF
data NOUN I-LF
statement NOUN I-LF
for ADP I-LF
pharmacoepidemiology NOUN I-LF
( PUNCT O
RECORD NOUN B-AC
- PUNCT B-AC
PE PROPN B-AC
) PUNCT O
guideline NOUN O
( PUNCT O
S1 PROPN O
Checklist PROPN O
) PUNCT O
. PUNCT O

ABOi PROPN B-AC
, PUNCT O
ABO PROPN B-LF
incompatible ADJ I-LF
; PUNCT O
KT PROPN B-AC
, PUNCT O
kidney NOUN B-LF
transplantation NOUN I-LF
; PUNCT O
ABOc PROPN B-AC
, PUNCT O
ABO PROPN B-LF
compatible ADJ I-LF
. PUNCT O

The DET O
galactose NOUN O
plates NOUN O
contained VERB O
1 NUM O
mg NOUN O
/ SYM O
l NOUN O
of ADP O
the DET O
respiration NOUN O
inhibitor NOUN O
Antimycin PROPN B-LF
A PROPN I-LF
( PUNCT O
AA PROPN B-AC
) PUNCT O
. PUNCT O

For ADP O
making VERB O
G NOUN B-LF
- NOUN I-LF
protein NOUN I-LF
coupled VERB I-LF
receptor NOUN I-LF
( PUNCT O
GPCR PROPN B-AC
) PUNCT O
transgenic ADJ O
reporters NOUN O
( PUNCT O
listed VERB O
in ADP O
S3 PROPN O
Table PROPN O
) PUNCT O
, PUNCT O
a DET O
PCR PROPN O
fusion NOUN O
approach NOUN O
was AUX O
used VERB O
[ X O
17 NUM O
] PUNCT O
. PUNCT O

Accordingly ADV O
, PUNCT O
we PRON O
need VERB O
to PART O
clarify VERB O
which DET O
risk NOUN O
factors NOUN O
promote VERB O
DD PROPN B-AC
to PART O
establish VERB O
preventive ADJ O
measures NOUN O
against ADP O
DD PROPN B-AC
. PUNCT O
In ADP O
the DET O
present ADJ O
study NOUN O
, PUNCT O
we PRON O
focused VERB O
on ADP O
metabolic ADJ B-LF
syndrome NOUN I-LF
( PUNCT O
MS PROPN B-AC
) PUNCT O
component NOUN O
, PUNCT O
such ADJ O
as ADP O
overweight NOUN B-LF
( PUNCT O
OW NOUN B-AC
) PUNCT O
, PUNCT O
hypertension NOUN B-LF
( PUNCT O
HT NOUN B-AC
) PUNCT O
, PUNCT O
dyslipidemia NOUN B-LF
( PUNCT O
DL NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
impaired ADJ B-LF
glucose NOUN I-LF
tolerance NOUN I-LF
( PUNCT O
IGT NOUN B-AC
) PUNCT O
, PUNCT O
because SCONJ O
MS PROPN B-AC
component NOUN O
has VERB O
some DET O
influence NOUN O
on ADP O
atherosclerosis NOUN O
[ PUNCT O
7 NUM O
] PUNCT O
and CCONJ O
accumulation NOUN O
of ADP O
MS PROPN B-AC
component NOUN O
increase VERB O
the DET O
risk NOUN O
of ADP O
atherosclerosis NOUN O
events NOUN O
[ PUNCT O
8 NUM O
] PUNCT O
. PUNCT O

Purified VERB O
RAG NOUN O
proteins NOUN O
can AUX O
, PUNCT O
however ADV O
, PUNCT O
transpose VERB O
a DET O
DNA NOUN O
sequence NOUN O
flanked VERB O
by ADP O
two NUM O
conserved VERB O
sequence NOUN O
elements NOUN O
( PUNCT O
recombination NOUN B-LF
signal NOUN I-LF
sequences NOUN I-LF
or CCONJ O
RSS NOUN B-AC
) PUNCT O
differing VERB O
in ADP O
length NOUN O
( PUNCT O
i.e. X O
, PUNCT O
a DET O
12 NUM O
- PUNCT O
RSS NOUN B-AC
and CCONJ O
a DET O
23 NUM O
- PUNCT O
RSS NOUN B-AC
) PUNCT O
into ADP O
an DET O
unrelated ADJ O
DNA NOUN O
target NOUN O
[ X O
5,6 NUM O
] PUNCT O
. PUNCT O

A X O
) PUNCT O
grain NOUN B-LF
yield NOUN I-LF
per ADP O
plant NOUN O
( PUNCT O
GY PROPN B-AC
) PUNCT O
, PUNCT O
B X O
) PUNCT O
thousand NUM O
kernel NOUN O
weight NOUN O
( PUNCT O
TKW PROPN B-AC
) PUNCT O
, PUNCT O
C X O
) PUNCT O
number NOUN B-LF
of ADP I-LF
kernels NOUN I-LF
per ADP I-LF
spike NOUN I-LF
( PUNCT O
NKS PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
D X O
) PUNCT O
number NOUN B-LF
of ADP I-LF
spikelets NOUN I-LF
per ADP I-LF
spike NOUN I-LF
( PUNCT O
NSS PROPN B-AC
) PUNCT O
. PUNCT O
Values NOUN O
are AUX O
the DET O
mean NOUN O
± NOUN O
SE NOUN O
of ADP O
four NUM O
replicates NOUN O
. PUNCT O

EN PROPN B-AC
: PUNCT O
Enteral ADJ B-LF
nutrition NOUN I-LF
; PUNCT O
IC PROPN O
: PUNCT O
Indirect ADJ O
calorimetry NOUN O
; PUNCT O
ICU PROPN B-AC
: PUNCT O
Intensive ADJ B-LF
care NOUN I-LF
unit NOUN I-LF
; PUNCT O
RRT NOUN O
: PUNCT O
Renal ADJ O
replacement NOUN O
therapy NOUN O
; PUNCT O
TPN NOUN B-AC
: PUNCT O
Total ADJ B-LF
parenteral ADJ I-LF
nutrition NOUN I-LF
. PUNCT O

The DET O
Abbreviated PROPN B-LF
Injury PROPN I-LF
Scale PROPN I-LF
( PUNCT O
AIS PROPN B-AC
) PUNCT O
of ADP O
body NOUN O
regions NOUN O
version NOUN O
2005 NUM O
and CCONJ O
the DET O
Injury PROPN B-LF
Severity PROPN I-LF
Score PROPN I-LF
( PUNCT O
ISS PROPN B-AC
) PUNCT O
were AUX O
used VERB O
as ADP O
surrogate ADJ O
measures NOUN O
of ADP O
injury NOUN O
severity NOUN O
. PUNCT O

OD PROPN B-AC
, PUNCT O
odds NOUN B-LF
ratios NOUN I-LF
; PUNCT O
95%CI NOUN O
, PUNCT O
relative ADJ O
95 NUM O
% NOUN O
confidence NOUN O
intervals NOUN O

Because SCONJ O
each DET O
mutant NOUN O
was AUX O
assayed VERB O
at ADP O
least ADV O
three NUM O
times NOUN O
, PUNCT O
the DET O
hyperoxia NOUN O
avoidance NOUN O
index NOUN O
could AUX O
be AUX O
used VERB O
for ADP O
standard ADJ O
statistical ADJ O
methods NOUN O
such ADJ O
as ADP O
analysis NOUN B-LF
of ADP I-LF
variance NOUN I-LF
( PUNCT O
ANOVA NOUN B-AC
) PUNCT O
. PUNCT O
In ADP O
a DET O
few ADJ O
cases NOUN O
, PUNCT O
the DET O
behavior NOUN O
of ADP O
animals NOUN O
in ADP O
the DET O
gradients NOUN O
showed VERB O
a DET O
significant ADJ O
shift NOUN O
in ADP O
the DET O
preferred VERB O
oxygen NOUN O
concentration NOUN O
that PRON O
was AUX O
not PART O
well ADV O
described VERB O
by ADP O
the DET O
hyperoxia NOUN O
avoidance NOUN O
index NOUN O
, PUNCT O
but CCONJ O
could AUX O
be AUX O
described VERB O
using VERB O
the DET O
median ADJ O
preferred VERB O
oxygen NOUN O
concentration NOUN O
. PUNCT O

The DET O
ratio NOUN O
of ADP O
percentage NOUN O
of ADP O
regulatory ADJ B-LF
T PROPN I-LF
cells NOUN I-LF
( PUNCT O
Treg NOUN B-AC
) PUNCT O
( PUNCT O
mainly ADV O
pTreg NOUN B-AC
cells NOUN O
[ PUNCT O
17 NUM O
] PUNCT O
) PUNCT O
to ADP O
percentage NOUN O
of ADP O
conventional ADJ O
T PROPN O
( PUNCT O
Tcon PROPN B-AC
) PUNCT O
cells NOUN O
of ADP O
Rag PROPN B-AC
- PUNCT B-AC
GFP PROPN B-AC
- PUNCT B-AC
neg PROPN B-AC
in ADP O
the DET O
thymus NOUN O
was AUX O
decreased VERB O
with ADP O
age NOUN O
( PUNCT O
Fig PROPN O
1D NUM O
, PUNCT O
left ADJ O
panel NOUN O
) PUNCT O
, PUNCT O
while SCONJ O
the DET O
absolute ADJ O
cell NOUN O
numbers NOUN O
of ADP O
both DET O
Rag PROPN B-AC
- PUNCT B-AC
GFP PROPN B-AC
- PUNCT B-AC
neg PROPN B-AC
populations NOUN O
( PUNCT O
Fig PROPN O
1D NUM O
, PUNCT O
right ADJ O
panel NOUN O
) PUNCT O
mirrored VERB O
the DET O
pattern NOUN O
observed VERB O
with ADP O
the DET O
Rag PROPN B-AC
- PUNCT O
GFP+ PROPN B-AC
population NOUN O
( PUNCT O
Fig PROPN O
1C NUM O
, PUNCT O
right ADJ O
panel NOUN O
) PUNCT O
. PUNCT O

DSS PROPN B-AC
, PUNCT O
dextran NOUN B-LF
sodium NOUN I-LF
sulfate NOUN I-LF
; PUNCT O
Rbpj PROPN B-AC
, PUNCT O
recombination NOUN B-LF
signal NOUN I-LF
binding VERB I-LF
protein NOUN I-LF
for ADP I-LF
immunoglobulin NOUN I-LF
kappa NOUN I-LF
J NOUN I-LF
region NOUN I-LF
; PUNCT O
TNBS PROPN O
, PUNCT O
2,4,6 NUM O
- PUNCT O
Trinitrobenzene NOUN O
sulfonic ADJ O
acid NOUN O
. PUNCT O

The DET O
MVA PROPN O
pathway NOUN O
begins VERB O
with ADP O
condensation NOUN O
of ADP O
acetyl NOUN O
- PUNCT O
CoA PROPN O
to ADP O
acetoacetyl NOUN O
- PUNCT O
CoA PROPN O
, PUNCT O
which PRON O
is AUX O
then ADV O
converted VERB O
to ADP O
isopentenyl NOUN B-LF
diphosphate NOUN I-LF
( PUNCT O
IPP PROPN B-AC
) PUNCT O
through ADP O
3 NUM B-LF
- PUNCT I-LF
hydroxy-3 NOUN I-LF
- PUNCT I-LF
methylglutaryl NOUN I-LF
- PUNCT I-LF
CoA PROPN I-LF
( PUNCT O
HMG PROPN B-AC
- PUNCT B-AC
CoA PROPN B-AC
) PUNCT O
and CCONJ O
mevalonate NOUN O
( PUNCT O
MVA PROPN O
) PUNCT O
. PUNCT O
IPP PROPN B-AC
acts VERB O
as ADP O
a DET O
precursor NOUN O
of ADP O
triterpenoids NOUN O
. PUNCT O

A DET O
group NOUN O
of ADP O
Ashkenazi ADJ O
Jewish ADJ O
centenarians NOUN O
( PUNCT O
n NOUN O
= SYM O
213 NUM O
) PUNCT O
, PUNCT O
their PRON O
offspring NOUN O
( PUNCT O
n NOUN O
= SYM O
216 NUM O
) PUNCT O
, PUNCT O
and CCONJ O
an DET O
age NOUN O
- PUNCT O
matched VERB O
Ashkenazi ADJ O
control NOUN O
group NOUN O
( PUNCT O
n NOUN O
= SYM O
258 NUM O
) PUNCT O
were AUX O
genotyped VERB O
for ADP O
66 NUM O
polymorphisms NOUN O
in ADP O
36 NUM O
candidate NOUN O
genes NOUN O
related VERB O
to ADP O
cardiovascular ADJ B-LF
disease NOUN I-LF
( PUNCT O
CVD NOUN B-AC
) PUNCT O
. PUNCT O
These DET O
genes NOUN O
were AUX O
tested VERB O
for ADP O
association NOUN O
with ADP O
serum NOUN O
lipoprotein NOUN O
levels NOUN O
and CCONJ O
particle NOUN O
sizes NOUN O
, PUNCT O
apolipoprotein NOUN O
A1 NOUN O
, PUNCT O
B PROPN O
, PUNCT O
and CCONJ O
C-3 PROPN O
levels NOUN O
and CCONJ O
with ADP O
outcomes NOUN O
of ADP O
hypertension NOUN O
, PUNCT O
insulin NOUN O
resistance NOUN O
, PUNCT O
and CCONJ O
mortality NOUN O
. PUNCT O

Lmod PROPN B-AC
, PUNCT O
leiomodin PROPN B-LF
; PUNCT O
RCI PROPN B-AC
, PUNCT O
random ADJ B-LF
coil NOUN I-LF
index NOUN I-LF
. PUNCT O

We PRON O
therefore ADV O
searched VERB O
relevant ADJ O
ChIP PROPN B-AC
data NOUN O
, PUNCT O
which PRON O
revealed VERB O
the DET O
existence NOUN O
of ADP O
a DET O
hotspot NOUN O
for ADP O
the DET O
binding NOUN O
of ADP O
pluripotency NOUN O
factors NOUN O
, PUNCT O
including VERB O
Oct4 PROPN O
, PUNCT O
Nanog PROPN O
, PUNCT O
Sox2 PROPN O
, PUNCT O
and CCONJ O
Klf4 PROPN O
, PUNCT O
in ADP O
a DET O
2 NUM O
kb NOUN O
region NOUN O
lying VERB O
1 NUM O
kb NOUN O
upstream ADV O
of ADP O
the DET O
Nodal ADJ O
transcription NOUN B-LF
start NOUN I-LF
site NOUN I-LF
( PUNCT O
TSS PROPN B-AC
) PUNCT O
( PUNCT O
Figure NOUN O
1A NOUN O
) PUNCT O
[ PUNCT O
22]–[26 X O
] PUNCT O
. PUNCT O

Reflexive ADJ O
visual ADJ O
responses NOUN O
were AUX O
assessed VERB O
using VERB O
an DET O
optokinetic ADJ B-LF
nystagmus NOUN I-LF
( PUNCT O
OKN PROPN B-AC
) PUNCT O
paradigm NOUN O
. PUNCT O

NLR PROPN B-AC
, PUNCT O
neutrophil NOUN B-LF
- ADJ I-LF
to ADP I-LF
- ADJ I-LF
lymphocyte NOUN I-LF
ratio NOUN I-LF
; PUNCT O
hs NOUN B-AC
- ADJ B-AC
CRP PROPN B-AC
, PUNCT O
high ADJ B-LF
sensitivity NOUN I-LF
C NOUN I-LF
- ADJ I-LF
reactive NOUN I-LF
protein NOUN I-LF
; PUNCT O
eGFR PROPN O
, PUNCT O
estimated VERB O
glomerular ADJ O
filtration NOUN O
rate NOUN O
according VERB O
to ADP O
the DET O
Modification PROPN O
of ADP O
Diet PROPN O
in ADP O
Renal PROPN O
Disease PROPN O
equation NOUN O
; PUNCT O
LDL PROPN O
, PUNCT O
low ADJ O
density NOUN O
lipoprotein;HDL NOUN O
, PUNCT O
high ADJ O
density NOUN O
lipoprotein NOUN O
; PUNCT O
NT NOUN B-AC
- ADJ B-AC
proBNP PROPN B-AC
, PUNCT O
n NOUN O
- ADJ O
terminal ADJ O
pro ADJ O
brain NOUN O
natriuretic ADJ O
peptide NOUN O
. PUNCT O

DWV PROPN B-AC
, PUNCT O
deformed VERB B-LF
wing NOUN I-LF
virus NOUN I-LF
. PUNCT O

As ADP O
such ADJ O
, PUNCT O
the DET O
developing VERB O
eye NOUN O
acts VERB O
as ADP O
a DET O
signaling VERB O
center NOUN O
nucleating VERB O
anterior ADJ O
segment NOUN O
morphogenesis NOUN O
, PUNCT O
with ADP O
paired VERB B-LF
- PUNCT I-LF
like ADJ I-LF
homeodomain NOUN I-LF
transcription NOUN I-LF
factor NOUN I-LF
2 NUM I-LF
( PUNCT O
PITX2 PROPN B-AC
) PUNCT O
being AUX O
the DET O
potential ADJ O
major ADJ O
downstream ADJ O
ATRA PROPN B-AC
effector NOUN O
in ADP O
periocular ADJ O
NCCs NOUN B-AC
[ X O
30,34–36 NUM O
] PUNCT O
. PUNCT O

The DET O
frequencies NOUN O
of ADP O
each DET O
animal NOUN B-LF
source NOUN I-LF
foods NOUN I-LF
the DET O
women NOUN O
ate VERB O
within ADP O
the DET O
days NOUN O
of ADP O
a DET O
week NOUN O
were AUX O
counted VERB O
to PART O
assess VERB O
animal NOUN B-LF
source NOUN I-LF
food NOUN I-LF
( PUNCT O
ASF PROPN B-AC
) PUNCT O
consumption NOUN O
. PUNCT O

DD PROPN B-AC
, PUNCT O
diversity NOUN B-LF
- PUNCT I-LF
dependent VERB I-LF
; PUNCT O
MLE PROPN B-AC
, PUNCT O
maximum ADJ B-LF
likelihood NOUN I-LF
estimate NOUN I-LF
; PUNCT O
PGLS PROPN B-AC
, PUNCT O
phylogenetic ADJ B-LF
generalized VERB I-LF
least ADJ I-LF
squares NOUN I-LF
. PUNCT O

Internal ADJ B-LF
standards NOUN I-LF
( PUNCT O
ISTD PROPN B-AC
) PUNCT O
WS NOUN B-AC
was AUX O
prepared VERB O
at ADP O
2000 NUM O
ng NOUN O
/ SYM O
mL NOUN O
by ADP O
adding VERB O
the DET O
required VERB O
volumes NOUN O
of ADP O
three NUM O
ISTD PROPN B-AC
stock NOUN O
solutions NOUN O
, PUNCT O
i.e. X O

Finally ADV O
, PUNCT O
we PRON O
also ADV O
consider VERB O
the DET O
more ADV O
canonical ADJ O
prediction NOUN O
that SCONJ O
the DET O
rTPJ PROPN B-AC
may AUX O
facilitate VERB O
choice NOUN O
of ADP O
delayed VERB O
rewards NOUN O
by ADP O
interacting VERB O
with ADP O
regions NOUN O
related VERB O
to ADP O
impulse NOUN O
control NOUN O
during ADP O
intertemporal ADJ O
choice NOUN O
, PUNCT O
such ADJ O
as ADP O
dorsolateral ADJ B-LF
prefrontal ADJ I-LF
cortex NOUN I-LF
( PUNCT O
DLPFC PROPN B-AC
) PUNCT O
[ X O
6,31 NUM O
] PUNCT O
. PUNCT O

The DET O
Sustainable PROPN O
Development PROPN O
Goals PROPN O
include VERB O
reducing VERB O
inequalities NOUN O
and CCONJ O
making VERB O
commitments NOUN O
to ADP O
universal ADJ B-LF
health NOUN I-LF
coverage NOUN I-LF
( PUNCT O
UHC PROPN B-AC
) PUNCT O
. PUNCT O

FEF25 NUM O
- SYM O
75 NUM O
% NOUN O
: PUNCT O
forced VERB O
expiratory ADJ O
flow NOUN O
at ADP O
25–75 NUM O
% NOUN O
of ADP O
FVC PROPN B-AC
. PUNCT O
FEV1 PROPN B-AC
: PUNCT O
1st ADJ B-LF
s NOUN I-LF
forced VERB I-LF
expiratory ADJ I-LF
volume NOUN I-LF
. PUNCT O

HSA PROPN B-AC
is AUX O
written VERB O
out ADP O
as ADP O
human ADJ B-LF
serum NOUN I-LF
albumin NOUN I-LF
. PUNCT O

CRB-65 PROPN B-AC
score NOUN B-AC
, PUNCT O
Confusion NOUN B-LF
/ SYM I-LF
Respiratory NOUN I-LF
rate NOUN I-LF
/ SYM I-LF
Blood NOUN I-LF
pressure NOUN I-LF
/ SYM I-LF
age NOUN I-LF
≥ NUM I-LF
65 NUM I-LF
years NOUN I-LF
score NOUN I-LF
; PUNCT O
qSOFA PROPN B-AC
score NOUN B-AC
, PUNCT O
quick ADJ O
Sequential PROPN O
Organ PROPN O
Failure PROPN O
Assessment PROPN O
score NOUN O
; PUNCT O
NEWS PROPN B-AC
, PUNCT O
National PROPN B-LF
Early PROPN I-LF
Warning PROPN I-LF
Score PROPN I-LF

Although SCONJ O
imatinib PROPN O
inhibits VERB O
different ADJ O
kinases NOUN O
in ADP O
various ADJ O
diseases NOUN O
( PUNCT O
BCR NOUN O
- PUNCT O
ABL PROPN O
in ADP O
CML PROPN B-AC
, PUNCT O
KIT PROPN O
or CCONJ O
PDGFR NOUN O
- PUNCT O
alpha NOUN O
in ADP O
gastrointestinal ADJ B-LF
stromal ADJ I-LF
tumors NOUN I-LF
[ PUNCT O
GISTs PROPN B-AC
] PUNCT O
, PUNCT O
and CCONJ O
PDGFR NOUN O
- PUNCT O
alpha NOUN O
in ADP O
hypereosinophilic ADJ B-LF
syndrome NOUN I-LF
[ PUNCT O
HES PROPN B-AC
] PUNCT O
) PUNCT O
( PUNCT O
reviewed VERB O
in ADP O
[ PUNCT O
14 NUM O
] PUNCT O
) PUNCT O
, PUNCT O
some DET O
tumors NOUN O
that PRON O
become VERB O
refractory ADJ O
to PART O
treatment NOUN O
with ADP O
imatinib PROPN O
appear VERB O
to PART O
have VERB O
analogous ADJ O
secondary ADJ O
mutations NOUN O
in ADP O
the DET O
kinase NOUN O
- PUNCT O
coding VERB O
domain NOUN O
of ADP O
the DET O
genes NOUN O
encoding VERB O
these DET O
three NUM O
enzymes NOUN O
. PUNCT O

To PART O
investigate VERB O
the DET O
correlation NOUN O
between ADP O
geographic ADJ O
filling NOUN O
delays NOUN O
in ADP O
the DET O
choriocapillaris NOUN O
using VERB O
indocyanine ADJ B-LF
green ADJ I-LF
angiography NOUN I-LF
( PUNCT O
ICGA PROPN B-AC
) PUNCT O
images NOUN O
and CCONJ O
dilated VERB O
vortex NOUN O
veins NOUN O
in ADP O
central ADJ B-LF
serous ADJ I-LF
chorioretinopathy NOUN I-LF
( PUNCT O
CSC PROPN B-AC
) PUNCT O
. PUNCT O

IUCN PROPN B-AC
, PUNCT O
International PROPN B-LF
Union PROPN I-LF
for ADP I-LF
Conservation PROPN I-LF
of ADP I-LF
Nature PROPN I-LF
. PUNCT O

Moreover ADV O
, PUNCT O
specific ADJ O
African ADJ O
trials NOUN O
have AUX O
indicated VERB O
that SCONJ O
the DET O
use NOUN O
of ADP O
insecticide NOUN B-LF
- PUNCT I-LF
treated VERB I-LF
nets NOUN I-LF
( PUNCT O
ITNs PROPN B-AC
) PUNCT O
or CCONJ O
indoor ADJ O
residual ADJ O
spraying NOUN O
can AUX O
reduce VERB O
mortality NOUN O
of ADP O
children NOUN O
under ADP O
five NUM O
in ADP O
Africa PROPN O
[ PUNCT O
6–9 NUM O
] PUNCT O
. PUNCT O

Chronic ADJ B-LF
low ADJ I-LF
back NOUN I-LF
pain NOUN I-LF
( PUNCT O
CLBP PROPN B-AC
) PUNCT O
is AUX O
widely ADV O
prevalent ADJ O
, PUNCT O
and CCONJ O
in ADP O
majority NOUN O
it PRON O
is AUX O
nonspecific ADJ O
( PUNCT O
no DET O
clear ADJ O
etiology NOUN O
) PUNCT O
in ADP O
nature NOUN O
. PUNCT O

These DET O
results NOUN O
were AUX O
consistent ADJ O
with ADP O
the DET O
ability NOUN O
of ADP O
CD5 PROPN O
- PUNCT O
2 NUM O
to PART O
inhibit VERB O
neutrophil NOUN O
migration NOUN O
into ADP O
inflamed ADJ O
tissue NOUN O
in ADP O
the DET O
MC38 PROPN O
colon NOUN O
carcinoma NOUN O
, PUNCT O
in ADP O
which PRON O
CD5 PROPN O
- PUNCT O
2 NUM O
inhibited VERB O
the DET O
number NOUN O
of ADP O
CD11b+/granulocyte NOUN O
( PUNCT O
Gr)1hi NOUN B-AC
in ADP O
the DET O
solid ADJ O
tumor NOUN O
tissue NOUN O
. PUNCT O

BMP PROPN B-AC
, PUNCT O
Bone PROPN B-LF
Morphogenetic PROPN I-LF
Protein PROPN I-LF
; PUNCT O
DV PROPN B-AC
, PUNCT O
dorsal ADJ B-LF
– SYM I-LF
ventral ADJ I-LF
; PUNCT O
scRNA NOUN B-AC
- PUNCT B-AC
seq NOUN B-AC
, PUNCT O
single ADJ B-LF
- PUNCT I-LF
cell NOUN I-LF
RNA NOUN I-LF
sequencing NOUN I-LF
. PUNCT O

Natural ADJ B-LF
killer NOUN I-LF
( PUNCT O
NK PROPN B-AC
) PUNCT O
cells NOUN O
kill VERB O
a DET O
target NOUN O
cell NOUN O
by ADP O
secreting VERB O
perforin NOUN O
into ADP O
the DET O
lytic ADJ O
immunological ADJ O
synapse NOUN O
, PUNCT O
a DET O
specialized ADJ O
interface NOUN O
formed VERB O
between ADP O
the DET O
NK PROPN B-AC
cell NOUN O
and CCONJ O
its PRON O
target NOUN O
. PUNCT O

CFU PROPN B-AC
, PUNCT O
colony NOUN B-LF
- PUNCT I-LF
forming VERB I-LF
unit NOUN I-LF
; PUNCT O
KO PROPN O
, PUNCT O
knockout NOUN O
; PUNCT O
TCR PROPN B-AC
, PUNCT O
T NOUN B-LF
- PUNCT I-LF
cell NOUN I-LF
receptor NOUN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

The DET O
Multiple PROPN B-LF
Sclerosis PROPN I-LF
Impact PROPN I-LF
Scale–29 PROPN I-LF
( PUNCT O
MSIS-29 PROPN B-AC
) PUNCT O
questionnaire NOUN O
is AUX O
a DET O
PRO NOUN B-AC
that PRON O
assesses VERB O
quality NOUN O
of ADP O
life NOUN O
in ADP O
people NOUN O
with ADP O
multiple ADJ B-LF
sclerosis NOUN I-LF
( PUNCT O
MS PROPN B-AC
) PUNCT O
. PUNCT O

The DET O
incidence NOUN B-LF
rate NOUN I-LF
( PUNCT O
IR NOUN B-AC
) PUNCT O
of ADP O
PD PROPN B-AC
in ADP O
the DET O
GTZ PROPN B-AC
- PUNCT O
using VERB O
group NOUN O
( PUNCT O
6.4 NUM O
per ADP O
10,000 NUM O
patient NOUN O
years NOUN O
, PUNCT O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
[ X O
CI NOUN B-AC
] X O
5.5–7.4 NUM O
) PUNCT O
was AUX O
lower ADJ O
than ADP O
the DET O
IR NOUN B-AC
of ADP O
PD PROPN B-AC
in ADP O
the DET O
matched VERB O
comparison NOUN O
cohort NOUN O
( PUNCT O
8.8 NUM O
per ADP O
10,000 NUM O
patient NOUN O
years NOUN O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN B-AC
8.1–9.6 NUM O
) PUNCT O
. PUNCT O

SM NOUN B-AC
, PUNCT O
sphingomyelin NOUN B-LF
; PUNCT O
AA PROPN O
, PUNCT O
amino NOUN O
acid NOUN O
; PUNCT O
CHO PROPN O
, PUNCT O
carbohydrate NOUN O
; PUNCT O
NT PROPN O
, PUNCT O
nucleotide NOUN O
; PUNCT O
CF_Vit PROPN O
, PUNCT O
cofactors NOUN O
and CCONJ O
vitamins NOUN O
; PUNCT O
Xeno PROPN O
, PUNCT O
xenobiotic NOUN O
; PUNCT O
FA PROPN B-AC
, PUNCT O
fatty ADJ B-LF
acid NOUN I-LF
; PUNCT O
FDR NOUN B-AC
, PUNCT O
false ADJ B-LF
discovery NOUN I-LF
rate NOUN I-LF
; PUNCT O
FC PROPN B-AC
, PUNCT O
fold NOUN B-LF
change NOUN I-LF
; PUNCT O
CON PROPN B-AC
, PUNCT O
control NOUN B-LF
diet NOUN I-LF
; PUNCT O
CPB PROPN B-AC
, PUNCT O
cardiac ADJ B-LF
protection NOUN I-LF
blend NOUN I-LF
. PUNCT O

Bypassing VERB O
restricted ADJ O
presentation NOUN O
of ADP O
conventional ADJ O
antigens NOUN O
which PRON O
typically ADV O
activate VERB O
< NOUN O
0.01 NUM O
% NOUN O
of ADP O
T NOUN O
cells NOUN O
, PUNCT O
superantigens NOUN O
bind VERB O
directly ADV O
as ADP O
intact ADJ O
proteins NOUN O
to PART O
most ADJ O
major ADJ B-LF
histocompatibility NOUN I-LF
class NOUN I-LF
II PROPN I-LF
( PUNCT O
MHC PROPN B-AC
- PROPN B-AC
II PROPN B-AC
) PUNCT O
and CCONJ O
T NOUN B-LF
cell NOUN I-LF
receptor NOUN I-LF
( PUNCT O
TCR PROPN B-AC
) PUNCT O
molecules NOUN O
, PUNCT O
activating VERB O
up ADP O
to PART O
20 NUM O
% NOUN O
of ADP O
T NOUN O
cells NOUN O
[ X O
9]–[11 X O
] PUNCT O
. PUNCT O

BU PROPN B-AC
, PUNCT O
Boston PROPN B-LF
University PROPN I-LF
; PUNCT O
HU PROPN O
, PUNCT O
Harvard PROPN B-AC
Univeristy PROPN O
; PUNCT O
tMRCA PROPN B-AC
, PUNCT O
time NOUN B-LF
to ADP I-LF
the DET I-LF
most ADV I-LF
recent ADJ I-LF
common ADJ I-LF
ancestor NOUN I-LF
; PUNCT O
UM PROPN O
, PUNCT O
University PROPN B-LF
of ADP I-LF
Massachusetts PROPN I-LF
Amherst PROPN I-LF
; PUNCT O
UMass PROPN B-AC
, PUNCT O
University PROPN B-LF
of ADP I-LF
Massachusetts PROPN I-LF
Amherst PROPN I-LF
. PUNCT O

In ADP O
line NOUN O
with ADP O
this DET O
widely ADV O
accepted VERB O
notion NOUN O
, PUNCT O
two NUM O
independent ADJ O
ATM PROPN B-LF
inhibitors NOUN I-LF
( PUNCT O
ATMi PROPN B-AC
) PUNCT O
, PUNCT O
KU-60019 PROPN B-LF
( PUNCT O
ATMi-1 PROPN B-AC
) PUNCT O
and CCONJ O
KU-55933 NOUN B-LF
( PUNCT O
ATMi-2 NOUN B-AC
) PUNCT O
, PUNCT O
significantly ADV O
reduced VERB O
DNA NOUN O
repair NOUN O
in ADP O
general ADJ O
( PUNCT O
Fig PROPN O
2A NOUN O
) PUNCT O
and CCONJ O
HR NOUN B-AC
( PUNCT O
Fig PROPN O
1F NUM O
) PUNCT O
. PUNCT O
Interestingly ADV O
, PUNCT O
HITT PROPN B-AC
completely ADV O
lost VERB O
its PRON O
ability NOUN O
to PART O
regulate VERB O
HR NOUN B-AC
repair NOUN O
in ADP O
the DET O
presence NOUN O
of ADP O
ATMi PROPN B-AC
( PUNCT O
Figs NOUN O
1F NUM O
and CCONJ O
2A NOUN O
) PUNCT O
. PUNCT O
ATMi PROPN B-AC
had VERB O
no DET O
obvious ADJ O
impacts NOUN O
on ADP O
HITT PROPN B-AC
expression NOUN O
levels NOUN O
( PUNCT O
S2A PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

The DET O
LN PROPN B-AC
hemilineage NOUN O
produces VERB O
LNs NOUN B-AC
exclusively ADV O
for ADP O
the DET O
AL PROPN B-AC
, PUNCT O
while SCONJ O
the DET O
PN PROPN B-AC
hemilineage NOUN O
generates VERB O
not PART O
only ADV O
AL PROPN B-AC
PNs NOUN B-AC
but CCONJ O
also ADV O
PNs NOUN B-AC
of ADP O
the DET O
antennal ADJ B-LF
mechanosensory NOUN I-LF
and CCONJ I-LF
motor NOUN I-LF
center NOUN I-LF
( PUNCT O
AMMC PROPN B-AC
) PUNCT O
and CCONJ O
suboesophageal ADJ B-LF
ganglion NOUN I-LF
( PUNCT O
SOG PROPN B-AC
) PUNCT O
. PUNCT O
Furthermore ADV O
, PUNCT O
the DET O
paired VERB O
hemilineages NOUN O
yield VERB O
diverse ADJ O
PNs NOUN B-AC
and CCONJ O
LNs NOUN B-AC
concurrently ADV O
but CCONJ O
in ADP O
distinct ADJ O
temporal ADJ O
patterns NOUN O
. PUNCT O

Idiopathic ADJ B-LF
pulmonary ADJ I-LF
fibrosis NOUN I-LF
( PUNCT O
IPF PROPN B-AC
) PUNCT O
constitutes VERB O
the DET O
most ADV O
prevalent ADJ O
type NOUN O
of ADP O
idiopathic ADJ B-LF
interstitial ADJ I-LF
pneumonia NOUN I-LF
( PUNCT O
IIP PROPN B-AC
) PUNCT O
, PUNCT O
accounting VERB O
for ADP O
55 NUM O
% NOUN O
of ADP O
IIP PROPN B-AC
cases NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

ICD PROPN B-AC
, PUNCT O
International PROPN B-LF
Classification PROPN I-LF
of ADP I-LF
Diseases PROPN I-LF
. PUNCT O

Reported ADJ O
Positive ADJ B-LF
Predictive ADJ I-LF
Values NOUN I-LF
( PUNCT O
PPVs NOUN B-AC
) PUNCT O
for ADP O
BI PROPN O
- PROPN O
RADS PROPN O
4 NUM O
lesions NOUN O
are AUX O
low ADJ O
, PUNCT O
ranging VERB O
from ADP O
20–65.2 NUM O
% NOUN O
as SCONJ O
assessed VERB O
by ADP O
histopathology NOUN O
[ PUNCT O
6–9 NUM O
] PUNCT O
. PUNCT O

ACTs NOUN B-AC
were AUX O
purchased VERB O
with ADP O
support NOUN O
from ADP O
African PROPN O
Development PROPN O
Bank PROPN O
and CCONJ O
Global PROPN B-LF
Fund PROPN I-LF
to PART I-LF
Fight VERB I-LF
AIDS PROPN I-LF
, PUNCT I-LF
Tuberculosis PROPN I-LF
and CCONJ I-LF
Malaria PROPN I-LF
( PUNCT O
GFATM PROPN B-AC
) PUNCT O
. PUNCT O

Pulse NOUN B-LF
pressure NOUN I-LF
( PUNCT O
PP NOUN B-AC
) PUNCT O
was AUX O
calculated VERB O
by ADP O
measuring VERB O
the DET O
difference NOUN O
between ADP O
SBP PROPN B-AC
and CCONJ O
DBP NOUN B-AC
. PUNCT O

VKAs PROPN B-AC
carry VERB O
a DET O
considerable ADJ O
risk NOUN O
of ADP O
adverse ADJ O
thromboembolic ADJ O
and CCONJ O
bleeding NOUN O
events NOUN O
, PUNCT O
particularly ADV O
in ADP O
the DET O
case NOUN O
of ADP O
dose NOUN O
deviations NOUN O
when SCONJ O
international ADJ B-LF
normalized ADJ I-LF
ratio NOUN I-LF
( PUNCT O
INR PROPN B-AC
) PUNCT O
values NOUN O
are AUX O
outside ADP O
the DET O
target NOUN O
range NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

DAPI PROPN B-AC
, PUNCT O
4′,6 NUM B-LF
- PUNCT I-LF
diamidino-2 NOUN I-LF
- PUNCT I-LF
phenylindole NOUN I-LF
; PUNCT O
DIC PROPN O
, PUNCT O
differential ADJ O
interference NOUN O
contrast NOUN O
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent NOUN I-LF
protein NOUN I-LF
; PUNCT O
IDC PROPN B-AC
, PUNCT O
intraerythrocytic ADJ B-LF
developmental ADJ I-LF
cycle NOUN I-LF
; PUNCT O
iRBC PROPN B-AC
, PUNCT O
infected ADJ B-LF
red ADJ I-LF
blood NOUN I-LF
cell NOUN I-LF
. PUNCT O

Treadmill NOUN O
exercise NOUN O
test NOUN O
and CCONJ O
cardiac ADJ B-LF
magnetic ADJ I-LF
resonance NOUN I-LF
imaging NOUN I-LF
( PUNCT O
CMR PROPN B-AC
) PUNCT O
were AUX O
performed VERB O
according VERB O
to ADP O
initial ADJ O
screening NOUN O
results NOUN O
. PUNCT O

Our PRON O
previous ADJ O
reports NOUN O
from ADP O
this DET O
program NOUN O
have AUX O
verified VERB O
the DET O
independent ADJ O
prognostic ADJ O
importance NOUN O
of ADP O
NTproBNP PROPN B-AC
, PUNCT O
cTnT NOUN B-AC
- PUNCT B-AC
hs NOUN B-AC
, PUNCT O
CRP NOUN B-AC
- PUNCT B-AC
hs NOUN B-AC
, PUNCT O
interleukin NOUN B-LF
6 NUM I-LF
( PUNCT O
IL-6 PROPN B-AC
) PUNCT O
, PUNCT O
growth NOUN B-LF
differentiation NOUN I-LF
factor NOUN I-LF
15 NUM I-LF
( PUNCT O
GDF-15 PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
lipoprotein NOUN B-LF
associated VERB I-LF
phospholipase NOUN I-LF
A2 PROPN I-LF
( PUNCT O
Lp PROPN B-AC
- PUNCT B-AC
PLA2 PROPN B-AC
) PUNCT O
[ PUNCT O
14–17 NUM O
] PUNCT O
. PUNCT O

GLM PROPN B-AC
, PUNCT O
general ADJ B-LF
linear ADJ I-LF
model NOUN I-LF
; PUNCT O
EOG PROPN O
, PUNCT O
electrooculography NOUN O
; PUNCT O
freq NOUN O
, PUNCT O
frequency NOUN O
; PUNCT O
TF NOUN B-AC
, PUNCT O
time NOUN B-LF
- PUNCT I-LF
frequency NOUN I-LF
. PUNCT O

Pilot NOUN O
studies NOUN O
with ADP O
exhaustive ADJ O
sampling NOUN O
, PUNCT O
progressive ADJ O
means NOUN O
analysis NOUN O
, PUNCT O
and CCONJ O
the DET O
formula NOUN O
of ADP O
West PROPN O
et X O
al NOUN O
. PUNCT O
, PUNCT O
[ X O
166 NUM O
] PUNCT O
, PUNCT O
as ADP O
well ADV O
as ADP O
a PRON O
posteriori X O
power NOUN O
analysis NOUN O
, PUNCT O
using VERB O
data NOUN O
from ADP O
our PRON O
previous ADJ O
studies NOUN O
of ADP O
cell NOUN O
and CCONJ O
axon NOUN O
densities NOUN O
, PUNCT O
or CCONJ O
tract NOUN O
tracing NOUN O
of ADP O
pathways NOUN O
, PUNCT O
took VERB O
into ADP O
consideration NOUN O
all DET O
known VERB O
and CCONJ O
estimated VERB O
variables NOUN O
, PUNCT O
including VERB O
age NOUN O
, PUNCT O
sex NOUN O
, PUNCT O
postmortem ADJ B-LF
interval NOUN I-LF
( PUNCT O
PMI PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
other ADJ O
diagnoses NOUN O
. PUNCT O

ICU PROPN B-AC
, PUNCT O
Intensive PROPN B-LF
Care PROPN I-LF
Unit PROPN I-LF
; PUNCT O
LSC PROPN B-AC
, PUNCT O
Life NOUN B-LF
Supporting VERB I-LF
Care PROPN I-LF
; PUNCT O
LSC PROPN B-AC
- PUNCT B-AC
L PROPN B-AC
, PUNCT O
Life NOUN B-LF
Supporting VERB I-LF
Care PROPN I-LF
Limitation PROPN I-LF
; PUNCT O
SAPS PROPN B-AC
II NUM B-AC
, PUNCT O
Simplified PROPN B-LF
Acute PROPN I-LF
Physiology PROPN I-LF
Score PROPN I-LF
; PUNCT O
SOFA PROPN B-AC
, PUNCT O
Sequential PROPN B-LF
Organ PROPN I-LF
failure PROPN I-LF
Assessment PROPN I-LF
; PUNCT O
LOS PROPN B-AC
, PUNCT O
Length PROPN B-LF
of ADP I-LF
stay NOUN I-LF
; PUNCT O
IMCU PROPN B-AC
, PUNCT O
Intermediate PROPN B-LF
Care PROPN I-LF
Unit PROPN I-LF
. PUNCT O

Dashed ADJ O
vertical ADJ O
red ADJ O
lines NOUN O
indicate VERB O
the DET O
age NOUN O
at ADP O
which PRON O
individuals NOUN O
with ADP O
previously ADV O
negative ADJ O
FIT NOUN B-AC
screening NOUN O
reach VERB O
the DET O
detection NOUN O
rate NOUN O
and CCONJ O
NNS PROPN B-AC
of ADP O
those PRON O
previously ADV O
unscreened ADJ O
. PUNCT O
FIT NOUN B-AC
, PUNCT O
fecal ADJ B-LF
immunochemical ADJ I-LF
test NOUN I-LF
; PUNCT O
NNS PROPN B-AC
, PUNCT O
number NOUN B-LF
needed VERB I-LF
to PART I-LF
scope VERB I-LF
. PUNCT O

Abbreviations NOUN O
: PUNCT O
BP PROPN B-AC
, PUNCT O
blood NOUN B-LF
pressure NOUN I-LF
; PUNCT O
RR NOUN B-AC
, PUNCT O
relative ADJ B-LF
risk NOUN I-LF
. PUNCT O

Recently ADV O
, PUNCT O
ancient ADJ O
DNA NOUN O
studies NOUN O
from ADP O
extinct ADJ O
animal NOUN O
specimens NOUN O
, PUNCT O
e.g. X O
, PUNCT O
the DET O
Elephant PROPN O
bird NOUN O
and CCONJ O
the DET O
Tasmanian ADJ O
tiger NOUN O
have AUX O
been AUX O
carried VERB O
out ADP O
by ADP O
high ADJ B-LF
- PUNCT I-LF
throughput NOUN I-LF
, PUNCT I-LF
“ PUNCT I-LF
next ADJ I-LF
- PUNCT I-LF
generation NOUN I-LF
” PUNCT I-LF
DNA NOUN I-LF
sequencing NOUN I-LF
( PUNCT O
NGS PROPN B-AC
) PUNCT O
technologies NOUN O
. PUNCT O

At ADP O
many ADJ O
levels NOUN O
of ADP O
the DET O
neuraxis NOUN O
, PUNCT O
the DET O
dorsoventral ADJ O
pattern NOUN O
of ADP O
progenitor NOUN O
cells NOUN O
, PUNCT O
which PRON O
later ADV O
gives VERB O
rise NOUN O
to ADP O
motor NOUN O
, PUNCT O
sensory ADJ O
, PUNCT O
and CCONJ O
local ADJ O
circuit NOUN O
neurons NOUN O
, PUNCT O
is AUX O
initiated VERB O
by ADP O
the DET O
opponent NOUN O
signaling NOUN O
activities NOUN O
of ADP O
Sonic PROPN B-LF
hedgehog NOUN I-LF
( PUNCT O
Shh PROPN B-AC
) PUNCT O
and CCONJ O
bone NOUN O
morphogenetic ADJ O
proteins NOUN O
[ PUNCT O
2 NUM O
, PUNCT O
4 NUM O
, PUNCT O
5 NUM O
] PUNCT O
. PUNCT O

Cancer NOUN O
and CCONJ O
cardiovascular ADJ B-LF
disease NOUN I-LF
( PUNCT O
CVD NOUN B-AC
) PUNCT O
were AUX O
previously ADV O
considered VERB O
2 NUM O
different ADJ O
pathologies NOUN O
. PUNCT O

Before ADP O
hepatectomy NOUN O
, PUNCT O
each DET O
patient NOUN O
received VERB O
ultrasonography NOUN O
, PUNCT O
contrast NOUN O
- PUNCT O
enhanced VERB O
magnetic ADJ B-LF
resonance NOUN I-LF
( PUNCT O
MR PROPN B-AC
) PUNCT O
, PUNCT O
and/or CCONJ O
tri ADJ O
- PUNCT O
phase ADJ O
contrast NOUN O
enhanced VERB O
helical ADJ O
computed VERB B-LF
tomography NOUN I-LF
( PUNCT O
CT PROPN B-AC
) PUNCT O
for ADP O
the DET O
diagnosis NOUN O
of ADP O
CHCC PROPN B-AC
- PUNCT B-AC
CC PROPN B-AC
and CCONJ O
evaluation NOUN O
of ADP O
the DET O
tumor NOUN O
. PUNCT O

Polyethyleneimine NOUN B-LF
( PUNCT O
PEI PROPN B-AC
) PUNCT O
solution NOUN O
( PUNCT O
50 NUM O
% NOUN O
) PUNCT O
, PUNCT O
sodium NOUN O
borate NOUN O
, PUNCT O
boric NOUN O
acid NOUN O
, PUNCT O
and CCONJ O
all DET O
other ADJ O
chemicals NOUN O
( PUNCT O
unless SCONJ O
stated VERB O
otherwise ADV O
) PUNCT O
are AUX O
obtained VERB O
from ADP O
Sigma PROPN O
- PUNCT O
Aldrich PROPN O
( PUNCT O
Zwijndrecht PROPN O
, PUNCT O
The DET O
Netherlands PROPN O
) PUNCT O
. PUNCT O

We PRON O
performed VERB O
a DET O
contemporary ADJ O
systematic ADJ O
review NOUN O
of ADP O
the DET O
published VERB O
literature NOUN O
in ADP O
accordance NOUN O
with ADP O
the DET O
Preferred PROPN B-LF
Reporting PROPN I-LF
Items PROPN I-LF
for ADP I-LF
Systematic PROPN I-LF
Reviews PROPN I-LF
and CCONJ I-LF
Meta PROPN I-LF
- PROPN I-LF
Analyses PROPN I-LF
( PUNCT O
PRISMA PROPN B-AC
) PUNCT O
guidelines NOUN O
( PUNCT O
S1 PROPN O
File PROPN O
) PUNCT O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
LGN PROPN B-AC
, PUNCT O
lateral ADJ B-LF
geniculate ADJ I-LF
nucleus NOUN I-LF
; PUNCT O
RF PROPN B-AC
, PUNCT O
receptive ADJ B-LF
field NOUN I-LF
; PUNCT O
SD NOUN O
, PUNCT O
standard ADJ O
deviation NOUN O
. PUNCT O

Following VERB O
phosphorylation NOUN O
of ADP O
the DET O
scaffold NOUN O
protein NOUN O
LAT PROPN O
by ADP O
activated VERB O
ZAP70 PROPN O
, PUNCT O
different ADJ O
signaling NOUN O
modules NOUN O
including VERB O
phospholipase NOUN B-LF
Cγ(PLCγ NOUN I-LF
) PUNCT O
are AUX O
activated VERB O
and CCONJ O
this PRON O
culminates VERB O
in ADP O
T NOUN O
cell NOUN O
activation NOUN O
[ PUNCT O
10 NUM O
] PUNCT O
. PUNCT O

IC50 NOUN B-AC
, PUNCT O
half ADJ B-LF
- PUNCT I-LF
maximal ADJ I-LF
inhibitory ADJ I-LF
concentration NOUN I-LF
; PUNCT O
OD NOUN B-AC
, PUNCT O
optical ADJ B-LF
density NOUN I-LF
. PUNCT O

Starting VERB O
from ADP O
the DET O
N NOUN O
- NOUN O
terminus NOUN O
, PUNCT O
the DET O
names NOUN O
and CCONJ O
in ADP O
parenthesis NOUN O
the DET O
exact ADJ O
amino NOUN O
acid NOUN O
sequences NOUN O
of ADP O
each DET O
domain NOUN O
are AUX O
as SCONJ O
follows VERB O
: PUNCT O
FimH PROPN O
lectin NOUN O
( PUNCT O
1–158 NUM O
) PUNCT O
, PUNCT O
FimH PROPN O
pilin NOUN O
( PUNCT O
161–279 NUM O
and CCONJ O
1–12 NUM O
of ADP O
donated VERB O
strand NOUN O
by ADP O
FimG PROPN O
subunit NOUN O
) PUNCT O
, PUNCT O
FimG PROPN O
( PUNCT O
16–144 NUM O
and CCONJ O
1–12 NUM O
of ADP O
donated VERB O
strand NOUN O
by ADP O
FimF PROPN O
subunit NOUN O
) PUNCT O
, PUNCT O
and CCONJ O
FimF PROPN O
( PUNCT O
16–154 NUM O
and CCONJ O
1–12 NUM O
of ADP O
donated VERB O
strand NOUN O
by ADP O
the DET O
second ADJ O
FimF PROPN O
) PUNCT O
. PUNCT O
In ADP O
this DET O
article NOUN O
, PUNCT O
if SCONJ O
not PART O
specified VERB O
, PUNCT O
FimG PROPN O
and CCONJ O
FimF PROPN O
always ADV O
refer VERB O
to ADP O
the DET O
domains NOUN O
and CCONJ O
FimH PROPN O
to ADP O
the DET O
lectin NOUN B-LF
domain NOUN I-LF
( PUNCT O
Ld PROPN B-AC
) PUNCT O
and CCONJ O
pilin NOUN B-LF
domain NOUN I-LF
( PUNCT O
Pd PROPN B-AC
) PUNCT O
including VERB O
the DET O
linker NOUN O
chain NOUN O
. PUNCT O

Hch PROPN B-AC
is AUX O
defined VERB O
to ADP O
describe VERB O
the DET B-LF
maximum ADJ I-LF
perpendicular ADJ I-LF
distance NOUN I-LF
from ADP I-LF
the DET I-LF
vertex NOUN I-LF
of ADP I-LF
the DET I-LF
arc NOUN I-LF
to ADP I-LF
Lch PROPN I-LF
. PUNCT O

The DET O
diagnoses NOUN O
used VERB O
in ADP O
the DET O
National PROPN O
Health PROPN O
Insurance PROPN O
Research PROPN O
Database PROPN O
( PUNCT O
NHIRD PROPN B-AC
) PUNCT O
are AUX O
coded VERB O
according VERB O
to ADP O
the DET O
diagnostic ADJ O
criteria NOUN O
of ADP O
the DET O
International PROPN B-LF
Classifications PROPN I-LF
of ADP I-LF
Diseases PROPN I-LF
, PUNCT I-LF
Revision PROPN I-LF
9 NUM I-LF
, PUNCT I-LF
Clinical PROPN I-LF
Modification PROPN I-LF
( PUNCT O
ICD-9 PROPN B-AC
- PUNCT B-AC
CM PROPN B-AC
) PUNCT O
. PUNCT O
The DET O
data NOUN O
analysts NOUN O
were AUX O
staff NOUN O
of ADP O
Kaohsiung PROPN O
Medical PROPN O
Center PROPN O
, PUNCT O
a DET O
site NOUN O
of ADP O
the DET O
Collaboration PROPN O
Center PROPN O
of ADP O
Health PROPN O
Information PROPN O
Application PROPN O
, PUNCT O
Ministry PROPN O
of ADP O
Health PROPN O
and CCONJ O
Welfare PROPN O
. PUNCT O

There PRON O
are VERB O
now ADV O
several ADJ O
classes NOUN O
of ADP O
ion NOUN O
channels NOUN O
implicated VERB O
in ADP O
the DET O
eukaryotic ADJ O
mechanotransduction NOUN O
machinery NOUN O
, PUNCT O
including VERB O
Piezo NOUN O
1 NUM O
and CCONJ O
2 NUM O
channels NOUN O
[ PUNCT O
11 NUM O
] X O
and CCONJ O
transient ADJ B-LF
receptor NOUN I-LF
potential NOUN I-LF
channels NOUN O
, PUNCT O
referred VERB O
as ADP O
TRP PROPN B-AC
channels NOUN O
. PUNCT O

Moreover ADV O
, PUNCT O
detailed ADJ O
clinical ADJ O
data NOUN O
of ADP O
the DET O
children NOUN O
, PUNCT O
such ADJ O
as ADP O
world NOUN B-LF
health NOUN I-LF
organization NOUN I-LF
( PUNCT O
WHO PROPN B-AC
) PUNCT O
HIV PROPN B-AC
disease NOUN O
stage NOUN O
, PUNCT O
OI PROPN B-AC
, PUNCT O
type NOUN O
of ADP O
HAART PROPN B-AC
and CCONJ O
HAART PROPN B-AC
experience NOUN O
and CCONJ O
duration NOUN O
of ADP O
HAART PROPN B-AC
were AUX O
collected VERB O
by ADP O
reviewing VERB O
the DET O
medical ADJ O
record NOUN O
of ADP O
HIV PROPN B-AC
infected VERB O
children NOUN O
. PUNCT O

ML PROPN B-AC
, PUNCT O
maximum ADJ B-LF
likelihood NOUN I-LF
; PUNCT O
MLE PROPN B-AC
, PUNCT O
maximum ADJ B-LF
likelihood NOUN I-LF
estimate NOUN I-LF
; PUNCT O
PGLS PROPN B-AC
, PUNCT O
phylogenetic ADJ B-LF
generalized VERB I-LF
least ADJ I-LF
squares NOUN I-LF
; PUNCT O
pPC NOUN B-AC
, PUNCT O
phylogenetic ADJ B-LF
principal ADJ I-LF
component NOUN I-LF
. PUNCT O

CSF PROPN B-AC
- PUNCT B-AC
cNs NOUN O
express VERB O
the DET O
transient ADJ O
potential NOUN O
receptor NOUN O
channel NOUN O
3 NUM O
( PUNCT O
Trpp3 PROPN O
) PUNCT O
, PUNCT O
further ADV O
referred VERB O
to ADP O
as ADP O
Pkd2l1 PROPN B-AC
( PUNCT O
for ADP O
Polycystic ADJ B-LF
kidney NOUN I-LF
disease-2 NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
1)[8,12,15 NUM I-LF
] PUNCT O
. PUNCT O

This DET O
effect NOUN O
was AUX O
particularly ADV O
clear ADJ O
with ADP O
trimethylated VERB B-LF
K4 NOUN I-LF
( PUNCT O
trimethyl NOUN B-AC
- PUNCT B-AC
K4 NOUN B-AC
) PUNCT O
H3 NOUN O
, PUNCT O
where SCONJ O
appearance NOUN O
of ADP O
higher ADJ O
bands NOUN O
corresponded VERB O
with ADP O
complete ADJ O
loss NOUN O
of ADP O
lower ADJ O
bands NOUN O
of ADP O
the DET O
ladder NOUN O
( PUNCT O
Figure NOUN O
1C NUM O
, PUNCT O
panel NOUN O
iii NUM O
) PUNCT O
. PUNCT O

Importantly ADV O
, PUNCT O
concomitant ADJ O
transfection NOUN O
of ADP O
MEFCtl PROPN O
. PUNCT O
cells NOUN O
with ADP O
an DET O
siRNA NOUN O
- PUNCT O
resistant ADJ O
, PUNCT O
wild ADJ B-LF
type NOUN I-LF
( PUNCT O
WT PROPN B-AC
) PUNCT O
CK1δ NOUN O
expression NOUN O
vector NOUN O
partially ADV O
restored VERB O
Chk1 PROPN B-AC
activation NOUN O
in ADP O
response NOUN O
to ADP O
HU PROPN O
( PUNCT O
Fig PROPN O
6 NUM O
) PUNCT O
. PUNCT O

We PRON O
found VERB O
both CCONJ O
Dip2a PROPN O
KO PROPN B-AC
mice NOUN O
and CCONJ O
WT PROPN B-AC
littermates NOUN O
spent VERB O
more ADJ O
time NOUN O
in ADP O
the DET O
chamber NOUN O
with ADP O
S1 PROPN B-AC
( PUNCT O
Fig PROPN O
7H NOUN O
and CCONJ O
S8F PROPN O
Fig PROPN O
) PUNCT O
, PUNCT O
indicating VERB O
an DET O
equal ADJ O
predilection NOUN O
for ADP O
S1 PROPN B-AC
. PUNCT O
In ADP O
the DET O
social ADJ O
novelty NOUN O
test NOUN O
, PUNCT O
another DET O
unfamiliar ADJ O
mouse NOUN O
was AUX O
introduced VERB O
as ADP O
a DET O
novel ADJ O
social ADJ O
partner NOUN O
( PUNCT O
stranger NOUN B-LF
2 NUM I-LF
, PUNCT O
S2 NOUN B-AC
) PUNCT O
into ADP O
the DET O
aforementioned ADJ O
empty ADJ O
cage NOUN O
( PUNCT O
S8 PROPN O
G PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

FLOWERING VERB B-LF
LOCUS PROPN I-LF
T PROPN I-LF
( PUNCT O
FT PROPN B-AC
) PUNCT O
, PUNCT O
widely ADV O
conserved VERB O
in ADP O
angiosperms NOUN O
, PUNCT O
is AUX O
a DET O
major ADJ O
component NOUN O
of ADP O
the DET O
mobile ADJ O
florigen NOUN O
. PUNCT O

Navigating VERB B-LF
the DET I-LF
healthcare NOUN I-LF
system NOUN I-LF
( PUNCT O
NHS PROPN B-AC
) PUNCT O
( PUNCT O
6 NUM O
items NOUN O
) PUNCT O
, PUNCT O

Abbreviations NOUN O
: PUNCT O
N NOUN O
, PUNCT O
number NOUN O
; PUNCT O
HR NOUN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT O
CI NOUN O
, PUNCT O
confidence NOUN O
interval NOUN O

Although SCONJ O
under ADP B-LF
- PUNCT I-LF
five NUM I-LF
mortality NOUN I-LF
rates NOUN I-LF
( PUNCT O
U5MR NOUN B-AC
) PUNCT O
and CCONJ O
neonatal ADJ B-LF
mortality NOUN I-LF
rates NOUN I-LF
( PUNCT O
NMR NOUN B-AC
) PUNCT O
have AUX O
declined VERB O
globally ADV O
, PUNCT O
from ADP O
91 NUM O
and CCONJ O
36 NUM O
to ADP O
43 NUM O
and CCONJ O
19 NUM O
per ADP O
1,000 NUM O
live ADJ O
births NOUN O
between ADP O
2000 NUM O
and CCONJ O
2015 NUM O
respectively ADV O
, PUNCT O
the DET O
degree NOUN O
of ADP O
progress NOUN O
varies VERB O
across ADP O
countries NOUN O
and CCONJ O
regions NOUN O
. PUNCT O

Key ADJ B-LF
Informant PROPN I-LF
Interview PROPN I-LF
( PUNCT O
KII PROPN B-AC
) PUNCT O
Guide NOUN O
. PUNCT O

The DET O
CFP PROPN B-AC
and CCONJ O
YFP PROPN B-AC
genes NOUN O
were AUX O
obtained VERB O
by ADP O
introducing VERB O
specific ADJ O
mutations NOUN O
in ADP O
the DET O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
( PUNCT O
GFP PROPN B-AC
) PUNCT O
gene NOUN O
. PUNCT O

We PRON O
performed VERB O
1:1 NUM O
propensity NOUN B-LF
score NOUN I-LF
( PUNCT O
PS PROPN B-AC
) PUNCT O
matching NOUN O
to PART O
establish VERB O
control NOUN O
group NOUN O
without ADP O
colon NOUN O
polyps NOUN O
that PRON O
mitigated VERB O
the DET O
confounding VERB O
effects NOUN O
of ADP O
age NOUN O
and CCONJ O
sex NOUN O
. PUNCT O

sIgE PROPN B-AC
, PUNCT O
specific ADJ B-LF
immunoglobulin NOUN I-LF
E. NOUN I-LF

Patients NOUN O
were AUX O
stratified VERB O
into ADP O
previously ADV B-LF
known VERB I-LF
hepatocellular ADJ I-LF
carcinoma NOUN I-LF
( PUNCT O
kHCC NOUN B-AC
, PUNCT O
n NOUN O
= SYM O
141 NUM O
) PUNCT O
and CCONJ O
incidental ADJ B-LF
hepatocellular ADJ I-LF
carcinoma NOUN I-LF
( PUNCT O
iHCC NOUN B-AC
, PUNCT O
n NOUN O
= SYM O
27 NUM O
) PUNCT O
. PUNCT O

Spinal ADJ O
extracellular ADJ B-LF
signal NOUN I-LF
- NOUN I-LF
regulated VERB I-LF
kinase NOUN I-LF
( PUNCT O
ERK PROPN B-AC
) PUNCT O
and CCONJ O
c NOUN O
- NOUN O
Jun NOUN O
N NOUN O
- NOUN O
terminal ADJ O
kinase NOUN O
phosphorylation NOUN O
also ADV O
peak VERB O
in ADP O
dorsal ADJ O
horn NOUN O
astrocytes NOUN O
three NUM O
weeks NOUN O
after ADP O
partial ADJ O
sciatic ADJ O
nerve NOUN O
ligation NOUN O
[ PUNCT O
23 NUM O
] PUNCT O
. PUNCT O

Underlying VERB O
data NOUN O
can AUX O
be AUX O
found VERB O
in ADP O
S1 PROPN O
Data PROPN O
. PUNCT O
ω-1 NOUN B-AC
, PUNCT O
omega-1 NOUN B-LF
; PUNCT O
BMDC PROPN B-AC
, PUNCT O
bone NOUN B-LF
marrow NOUN I-LF
– PUNCT I-LF
derived VERB I-LF
DC PROPN I-LF
; PUNCT O
CD4 PROPN B-AC
, PUNCT O
cluster NOUN B-LF
of ADP I-LF
differentiation NOUN I-LF
4 NUM I-LF
; PUNCT O
IL-17A PROPN O
, PUNCT O
interleukin NOUN O
17A NUM O
; PUNCT O
SEA PROPN B-AC
, PUNCT O
soluble ADJ B-LF
egg NOUN I-LF
antigen NOUN I-LF
; PUNCT O
Th17 PROPN O
, PUNCT O
T NOUN O
helper NOUN O
17 NUM O
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

GSH PROPN B-AC
, PUNCT O
reduced ADJ B-LF
glutathione NOUN I-LF
; PUNCT O
GSX PROPN B-AC
, PUNCT O
glutathione NOUN B-LF
S NOUN I-LF
- PUNCT I-LF
conjugate NOUN I-LF
; PUNCT O
HPLC PROPN B-AC
, PUNCT O
High PROPN B-LF
- PUNCT I-LF
Performance PROPN I-LF
Liquid PROPN I-LF
Chromatography NOUN I-LF
; PUNCT O
LC PROPN B-AC
– PUNCT B-AC
MS PROPN B-AC
, PUNCT O
liquid NOUN B-LF
chromatography NOUN I-LF
– PUNCT I-LF
mass NOUN I-LF
spectrometry NOUN I-LF
; PUNCT O
met− NOUN O
, PUNCT O
methionine NOUN O
- PUNCT O
requiring VERB O
mutant NOUN O
; PUNCT O
TCEP PROPN B-AC
, PUNCT O
tris(2 NOUN B-LF
- PUNCT I-LF
carboxyethyl)phosphine NOUN I-LF
. PUNCT O

Previous ADJ O
network NOUN O
meta ADJ O
analyses NOUN O
on ADP O
hypoglycemic ADJ O
drugs NOUN O
were AUX O
focused VERB O
on ADP O
intermediate ADJ O
outcomes NOUN O
, PUNCT O
such ADJ O
as ADP O
glycated ADJ B-LF
hemoglobin NOUN I-LF
( PUNCT O
HbA1c NOUN B-AC
) PUNCT O
, PUNCT O
or CCONJ O
did AUX O
not PART O
compare VERB O
the DET O
effect NOUN O
of ADP O
the DET O
drugs NOUN O
on ADP O
mortality NOUN O
or CCONJ O
major ADJ B-LF
adverse ADJ I-LF
cardiovascular ADJ I-LF
events NOUN I-LF
( PUNCT O
MACE PROPN B-AC
) PUNCT O
in ADP O
the DET O
absence NOUN O
of ADP O
data NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

The DET O
reference NOUN O
and CCONJ O
intervention NOUN O
TFA PROPN O
intakes NOUN O
and CCONJ O
the DET O
relative ADJ O
risk NOUN O
of ADP O
IHD NOUN B-AC
per ADP O
% NOUN O
E NOUN O
of ADP O
TFA PROPN O
intake NOUN O
were AUX O
used VERB O
to ADP O
calculate VERB O
the DET O
potential ADJ B-LF
impact NOUN I-LF
fraction NOUN I-LF
( PUNCT O
PIF NOUN B-AC
) PUNCT O
for ADP O
estimation NOUN O
of ADP O
the DET O
proportional ADJ O
change NOUN O
in ADP O
IHD NOUN B-AC
incidence NOUN O
due ADJ O
to ADP O
the DET O
elimination NOUN O
of ADP O
iTFAs NOUN B-AC
( PUNCT O
Eq NOUN O
( PUNCT O
1 NUM O
) PUNCT O
) PUNCT O
. PUNCT O

It PRON O
has AUX O
been AUX O
shown VERB O
that SCONJ O
HGF PROPN B-AC
is AUX O
expressed VERB O
along ADP O
this DET O
anatomic ADJ O
pathway NOUN O
[ PUNCT O
23 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
mice NOUN O
with ADP O
absence NOUN O
of ADP O
the DET O
HGF PROPN B-AC
receptor NOUN O
c NOUN O
- PUNCT O
Met NOUN O
fail VERB O
to PART O
form VERB O
muscularized ADJ O
pleuroperitoneal ADJ B-LF
folds NOUN I-LF
( PUNCT O
PPFs NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
thus ADV O
have VERB O
amuscular ADJ O
diaphragms NOUN O
[ PUNCT O
24,25 NUM O
] PUNCT O
. PUNCT O

CI PROPN B-AC
, PUNCT O
competitive ADJ B-LF
index NOUN I-LF
. PUNCT O

Prognostic ADJ O
assessment NOUN O
in ADP O
patients NOUN O
with ADP O
hepatocellular ADJ B-LF
carcinoma NOUN I-LF
( PUNCT O
HCC PROPN B-AC
) PUNCT O
remains VERB O
controversial ADJ O
. PUNCT O

AMP PROPN B-AC
, PUNCT O
ampicillin NOUN B-LF
; PUNCT O
CHL PROPN B-AC
, PUNCT O
chloramphenicol NOUN B-LF
; PUNCT O
CIP PROPN B-AC
, PUNCT O
ciprofloxacin NOUN B-LF
; PUNCT O
CRO PROPN B-AC
, PUNCT O
ceftriaxone NOUN B-LF
; PUNCT O
DAP PROPN B-AC
, PUNCT O
daptomycin NOUN B-LF
; PUNCT O
DOX PROPN B-AC
, PUNCT O
doxycycline NOUN B-LF
; PUNCT O
FOF PROPN B-AC
, PUNCT O
fosfomycin NOUN B-LF
; PUNCT O
LVX PROPN O
, PUNCT O
levofloxacin NOUN O
; PUNCT O
LZD PROPN B-AC
, PUNCT O
linezolid NOUN B-LF
; PUNCT O
mut NOUN O
, PUNCT O
mutant NOUN O
; PUNCT O
NIT PROPN B-AC
, PUNCT O
nitrofurantoin NOUN B-LF
; PUNCT O
OD PROPN B-AC
, PUNCT O
optical ADJ B-LF
density NOUN I-LF
; PUNCT O
OXA PROPN B-AC
, PUNCT O
oxacillin NOUN B-LF
; PUNCT O
RIF PROPN B-AC
, PUNCT O
rifampicin NOUN B-LF
; PUNCT O
SPT PROPN B-AC
, PUNCT O
spectinomycin NOUN B-LF
; PUNCT O
TET PROPN O
, PUNCT O
tetracycline NOUN O
; PUNCT O
TGC PROPN B-AC
, PUNCT O
tigecycline NOUN B-LF
. PUNCT O

OxLDL NOUN B-AC
, PUNCT O
oxLDL NOUN O
/ SYM O
HDL PROPN B-AC
, PUNCT O
and CCONJ O
oxLDL NOUN O
/ SYM O
LDL NOUN B-AC
correlated VERB O
significantly ADV O
with ADP O
each DET O
other ADJ O
and CCONJ O
with ADP O
all DET O
conventional ADJ O
lipid NOUN O
biomarkers NOUN O
, PUNCT O
total ADJ B-LF
cholesterol NOUN I-LF
( PUNCT O
TC PROPN B-AC
) PUNCT O
, PUNCT O
triglycerides NOUN B-LF
( PUNCT O
TG PROPN B-AC
) PUNCT O
, PUNCT O
HDL PROPN B-AC
and CCONJ O
LDL NOUN B-AC
( PUNCT O
with ADP O
the DET O
exception NOUN O
that SCONJ O
oxLDL NOUN O
/ SYM O
LDL NOUN B-AC
did AUX O
not PART O
correlate VERB O
with ADP O
TC PROPN B-AC
) PUNCT O
. PUNCT O
HbA1c PROPN O
was AUX O
weakly ADV O
correlated VERB O
with ADP O
TG PROPN B-AC
and CCONJ O
negatively ADV O
correlated VERB O
with ADP O
HDL PROPN B-AC
. PUNCT O
CRP PROPN B-AC
was AUX O
also ADV O
negatively ADV O
correlated VERB O
with ADP O
HDL PROPN B-AC
. PUNCT O
IL6 PROPN B-AC
was AUX O
weakly ADV O
correlated VERB O
with ADP O
TC PROPN B-AC
and CCONJ O
negatively ADV O
correlated VERB O
with ADP O
TG PROPN B-AC
. PUNCT O
OxLDL NOUN B-AC
, PUNCT O
oxLDL NOUN O
/ SYM O
HDL PROPN B-AC
and CCONJ O
oxLDL NOUN O
/ SYM O
LDL NOUN B-AC
were AUX O
moderately ADV O
correlated VERB O
with ADP O
CRP PROPN B-AC
. PUNCT O
OxLDL NOUN B-AC
was AUX O
negatively ADV O
correlated VERB O
with ADP O
IL6 PROPN B-AC
. PUNCT O
CRP PROPN B-AC
was AUX O
moderately ADV O
correlated VERB O
with ADP O
IL6 PROPN B-AC
. PUNCT O
OxLDL NOUN B-AC
/ SYM O
HDL PROPN B-AC
and CCONJ O
CRP PROPN B-AC
were AUX O
negatively ADV O
correlated VERB O
with ADP O
age NOUN O
. PUNCT O

This DET O
model NOUN O
included VERB O
the DET O
4 NUM O
biomarkers NOUN O
NTproBNP PROPN B-AC
, PUNCT O
TIM-1 PROPN B-AC
, PUNCT O
osteopontin NOUN O
, PUNCT O
and CCONJ O
tissue NOUN B-LF
inhibitor NOUN I-LF
of ADP I-LF
metalloproteinase-1 NOUN I-LF
( PUNCT O
TIMP-1 PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
had VERB O
a DET O
c NOUN O
- NOUN O
index NOUN O
of ADP O
0.79 NUM O
. PUNCT O

AUC PROPN B-AC
, PUNCT O
area NOUN B-LF
under ADP I-LF
the DET I-LF
curve NOUN I-LF
; PUNCT O
D PROPN O
, PUNCT O
dioptres NOUN O
; PUNCT O
DGC PROPN B-AC
, PUNCT O
Dongguan PROPN B-LF
Guangming PROPN I-LF
Ophthalmic PROPN I-LF
Hospital PROPN I-LF
; PUNCT O
HKC PROPN B-AC
, PUNCT O
Xiuying PROPN B-LF
Optometry PROPN I-LF
Department PROPN I-LF
in ADP I-LF
Haikou PROPN I-LF
City PROPN I-LF
; PUNCT O
HPD PROPN B-AC
, PUNCT O
Huangpu PROPN B-LF
Optometry PROPN I-LF
Department PROPN I-LF
; PUNCT O
HZC PROPN B-AC
, PUNCT O
Optometry PROPN B-LF
Centre PROPN I-LF
in ADP I-LF
Huizhou PROPN I-LF
City PROPN I-LF
; PUNCT O
HZD PROPN B-AC
, PUNCT O
Haizhu PROPN B-LF
Optometry PROPN I-LF
Department PROPN I-LF
; PUNCT O
LHD PROPN B-AC
, PUNCT O
Haikou PROPN B-LF
Longhua PROPN I-LF
Optometry PROPN I-LF
Department PROPN I-LF
; PUNCT O
MAE PROPN B-AC
, PUNCT O
mean ADJ B-LF
absolute ADJ I-LF
error NOUN I-LF
; PUNCT O
PYD PROPN B-AC
, PUNCT O
Panyu PROPN B-LF
Optometry PROPN I-LF
Department PROPN I-LF
. PUNCT O

The DET O
measured VERB O
parameters NOUN O
included VERB O
body NOUN B-LF
mass NOUN I-LF
( PUNCT O
BM PROPN B-AC
) PUNCT O
, PUNCT O
fat NOUN O
- PUNCT O
free ADJ O
mass NOUN O
( PUNCT O
FFM PROPN B-AC
) PUNCT O
, PUNCT O
body NOUN B-LF
fat NOUN I-LF
( PUNCT O
BF PROPN B-AC
) PUNCT O
, PUNCT O
bone NOUN B-LF
mineral NOUN I-LF
content NOUN I-LF
( PUNCT O
BMC PROPN B-AC
) PUNCT O
, PUNCT O
bone NOUN B-LF
mineral NOUN I-LF
density NOUN I-LF
( PUNCT O
BMD PROPN B-AC
) PUNCT O
. PUNCT O
For ADP O
the DET O
whole ADJ O
- PUNCT O
body NOUN O
analysis NOUN O
, PUNCT O
the DET O
determined VERB O
TEM PROPN B-AC
was AUX O
: PUNCT O
BM PROPN B-AC
at ADP O
the DET O
level NOUN O
of ADP O
0.12 NUM O
kg NOUN O
in ADP O
females NOUN O
and CCONJ O
0.29 NUM O
kg NOUN O
in ADP O
males NOUN O
; PUNCT O
BF PROPN B-AC
0.25 NUM O
kg NOUN O
and CCONJ O
0.44 NUM O
% NOUN O
females NOUN O
, PUNCT O
0.52 NUM O
kg NOUN O
and CCONJ O
0.66 NUM O
% NOUN O
males NOUN O
; PUNCT O
FFM PROPN B-AC
0.24 NUM O
kg NOUN O
females NOUN O
and CCONJ O
0.42 NUM O
kg NOUN O
males NOUN O
; PUNCT O
BMC PROPN B-AC
0.02 NUM O
kg NOUN O
females NOUN O
and CCONJ O
males NOUN O
; PUNCT O
BMD PROPN B-AC
0.01g NUM O
/ SYM O
cm2 NUM O
females NOUN O
and CCONJ O
males NOUN O
. PUNCT O

In ADP O
order NOUN O
to PART O
avoid VERB O
exposure NOUN O
, PUNCT O
healthcare NOUN O
workers NOUN O
are AUX O
required VERB O
to PART O
wear VERB O
personal ADJ B-LF
protective ADJ I-LF
equipment NOUN I-LF
( PUNCT O
PPE PROPN B-AC
) PUNCT O
[ PUNCT O
5 NUM O
, PUNCT O
6 NUM O
] PUNCT O
, PUNCT O
of ADP O
which PRON O
, PUNCT O
the DET O
broad ADJ O
distribution NOUN O
and CCONJ O
availability NOUN O
is AUX O
often ADV O
a DET O
challenge NOUN O
especially ADV O
before ADP O
upcoming ADJ O
outbreaks NOUN O
. PUNCT O

Globally ADV O
, PUNCT O
the DET O
capacity NOUN O
of ADP O
available ADJ O
CD4 NOUN B-AC
instruments NOUN O
was AUX O
found VERB O
to PART O
be AUX O
sufficient ADJ O
to PART O
meet VERB O
the DET O
demand NOUN O
of ADP O
all DET O
people NOUN B-LF
living VERB I-LF
with ADP I-LF
HIV PROPN I-LF
/ SYM I-LF
AIDS PROPN I-LF
( PUNCT O
PLWHA PROPN B-AC
) PUNCT O
, PUNCT O
irrespective ADV O
of ADP O
treatment NOUN O
status NOUN O
; PUNCT O
however ADV O
, PUNCT O
capacity NOUN O
to PART O
measure VERB O
viral ADJ O
load NOUN O
was AUX O
inadequate ADJ O
to PART O
cover VERB O
needs NOUN O
in ADP O
most ADJ O
reporting VERB O
countries NOUN O
. PUNCT O

CI PROPN B-AC
- PUNCT B-AC
MPR PROPN B-AC
, PUNCT O
cation NOUN B-LF
- PUNCT I-LF
independent ADJ I-LF
mannose NOUN I-LF
6 NUM I-LF
- PUNCT I-LF
phosphate NOUN I-LF
receptor NOUN I-LF
; PUNCT O
PX PROPN B-AC
, PUNCT O
phox NOUN B-LF
- PUNCT I-LF
homology NOUN I-LF
; PUNCT O
SNX PROPN B-AC
, PUNCT O
Sorting PROPN B-LF
Nexin PROPN I-LF
family NOUN I-LF
. PUNCT O

GFR PROPN B-AC
= VERB O
glomerular ADJ B-LF
filtration NOUN I-LF
rate NOUN I-LF
; PUNCT O
other ADJ O
abbreviations NOUN O
as ADP O
in ADP O
Table NOUN O
2 NUM O
. PUNCT O

The DET O
exclusion NOUN O
criteria NOUN O
were AUX O
patients NOUN O
with ADP O
positive ADJ O
urinalysis NOUN O
and CCONJ O
urine NOUN O
culture NOUN O
, PUNCT O
patients NOUN O
who PRON O
had AUX O
been AUX O
exposed VERB O
to PART O
irradiation NOUN O
or CCONJ O
hormonal ADJ O
therapy NOUN O
in ADP O
the DET O
previous ADJ O
six NUM O
months NOUN O
, PUNCT O
patients NOUN O
with ADP O
neurological ADJ O
diseases NOUN O
, PUNCT O
patients NOUN O
using VERB O
anticholinergic ADJ O
drugs NOUN O
, PUNCT O
calcium NOUN O
antagonists NOUN O
, PUNCT O
b NOUN O
- PUNCT O
antagonists NOUN O
, PUNCT O
or CCONJ O
dopamine NOUN O
antagonists NOUN O
, PUNCT O
patients NOUN O
with ADP O
a DET O
grading NOUN O
≥ ADP O
grade NOUN O
III NUM O
according VERB O
to PART O
the DET O
pelvic ADJ B-LF
organ NOUN I-LF
prolapse NOUN I-LF
quantification NOUN I-LF
system NOUN O
( PUNCT O
POP PROPN B-AC
- PUNCT B-AC
Q PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
those PRON O
unable ADJ O
to PART O
satisfactorily ADV O
answer VERB O
the DET O
questionnaires NOUN O
and CCONJ O
with ADP O
severe ADJ O
depression NOUN O
. PUNCT O

OA PROPN B-AC
, PUNCT O
elevated ADJ B-LF
CO2 NOUN I-LF
; PUNCT O
T NOUN O
, PUNCT O
elevated ADJ O
temperature NOUN O
. PUNCT O

Proliferating ADJ B-LF
cell NOUN I-LF
nuclear ADJ I-LF
antigen NOUN I-LF
( PUNCT O
PCNA PROPN B-AC
) PUNCT O
was AUX O
used VERB O
as ADP O
a DET O
protein NOUN O
loading NOUN O
control NOUN O
and CCONJ O
was AUX O
detected VERB O
using VERB O
a DET O
mouse ADJ O
monoclonal ADJ O
antibody NOUN O
( PUNCT O
clone NOUN O
PC10 PROPN O
, PUNCT O
Calbiochem PROPN O
) PUNCT O
followed VERB O
by ADP O
a DET O
secondary ADJ O
sheep NOUN O
anti ADJ O
- ADJ O
mouse ADJ O
antibody NOUN O
conjugated VERB O
to ADP O
horseradish NOUN O
peroxidase NOUN O
. PUNCT O

In ADP O
Nayapara PROPN O
, PUNCT O
estimated VERB O
seroprotection NOUN O
among ADP O
1- NUM O
to PART O
6 NUM O
- PUNCT O
year NOUN O
- PUNCT O
olds NOUN O
was AUX O
high ADJ O
for ADP O
measles NOUN O
, PUNCT O
rubella NOUN O
, PUNCT O
diphtheria NOUN O
, PUNCT O
and CCONJ O
tetanus NOUN O
( PUNCT O
91%–98 NUM O
% PUNCT O
; PUNCT O
95 NUM O
% PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
[ X O
CI NOUN B-AC
] X O
87%–99 NUM O
% PUNCT O
) PUNCT O
; PUNCT O
children NOUN O
> NUM O
6 NUM O
years NOUN O
were AUX O
not PART O
assessed VERB O
. PUNCT O

FODMAP PROPN B-AC
= PUNCT O
Fermentable ADJ B-LF
Oligosaccharides NOUN I-LF
, PUNCT I-LF
Disaccharides NOUN I-LF
, PUNCT I-LF
Monosaccharides NOUN I-LF
and CCONJ I-LF
Polyols NOUN I-LF
; PUNCT O
IBS PROPN B-AC
= PUNCT O
Irritable ADJ B-LF
Bowel PROPN I-LF
Syndrome PROPN I-LF
; PUNCT O
IBS PROPN B-AC
- PUNCT O
D PROPN O
= PUNCT O
IBS PROPN B-AC
- PUNCT O
Diarrhoeal PROPN O
subtype NOUN O
; PUNCT O
IBS PROPN B-AC
- PUNCT O
C PROPN O
= PUNCT O
IBS PROPN B-AC
- PUNCT O
Constipation NOUN O
subtype NOUN O
; PUNCT O
IBS PROPN B-AC
- PUNCT O
M PROPN O
/ SYM O
A PROPN O
= PUNCT O
IBS PROPN B-AC
- PUNCT O
Mixed PROPN O
/ SYM O
Alternation PROPN O
subtype NOUN O
; PUNCT O
IBS PROPN B-AC
- PUNCT O
U PROPN O
= PUNCT O
IBS PROPN B-AC
- PUNCT O
Unsubtyped PROPN O
; PUNCT O
Suppl NOUN O
. PUNCT O
= PUNCT O
Supplementary ADJ O
material NOUN O
. PUNCT O

A DET O
total NOUN O
of ADP O
89 NUM O
patients NOUN O
with ADP O
detectable ADJ O
baseline NOUN O
mutations NOUN O
and CCONJ O
serial ADJ O
ctDNA PROPN B-AC
testing NOUN O
data NOUN O
were AUX O
included VERB O
in ADP O
the DET O
analysis NOUN O
. PUNCT O
ctDNA PROPN B-AC
, PUNCT O
circulating VERB B-LF
tumor NOUN I-LF
DNA NOUN I-LF
; PUNCT O
HR NOUN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT O
HR_feature NOUN B-AC
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
risk NOUN I-LF
feature NOUN I-LF
; PUNCT O
nCRT PROPN B-AC
, PUNCT O
neoadjuvant ADJ B-LF
chemoradiotherapy NOUN I-LF
; PUNCT O
RFS PROPN B-AC
, PUNCT O
recurrence NOUN B-LF
- PUNCT I-LF
free ADJ I-LF
survival NOUN I-LF
; PUNCT O
95 NUM B-AC
% NOUN B-AC
CI NOUN B-AC
, PUNCT O
95 NUM B-LF
% NOUN I-LF
confidence NOUN I-LF
interval NOUN I-LF
. PUNCT O

MLE PROPN B-AC
, PUNCT O
maximum ADJ B-LF
likelihood NOUN I-LF
estimate NOUN I-LF
. PUNCT O

d. X O
Likelihood NOUN B-LF
ratio NOUN I-LF
statistics NOUN I-LF
( PUNCT O
LRS NOUN B-AC
) PUNCT O
were AUX O
calculated VERB O
using VERB O
Map PROPN O
Manager PROPN O
QTXb20 PROPN O
. PUNCT O

During ADP O
the DET O
initiation NOUN O
of ADP O
autophagy NOUN O
, PUNCT O
several ADJ O
other ADJ O
key ADJ O
modulators NOUN O
of ADP O
the DET O
Becn-1 PROPN O
- PUNCT O
Vps34 PROPN O
- PUNCT O
Atg14L PROPN O
complex NOUN O
were AUX O
identified VERB O
, PUNCT O
including VERB O
Unc-51 PROPN B-LF
Like ADP I-LF
Autophagy PROPN I-LF
Activating PROPN I-LF
Kinase PROPN I-LF
1 NUM I-LF
( PUNCT O
ULK1 PROPN B-AC
) PUNCT O
and CCONJ O
Autophagy PROPN B-LF
And CCONJ I-LF
Beclin PROPN I-LF
1 NUM I-LF
Regulator PROPN I-LF
1 NUM I-LF
( PUNCT O
AMBRA1 PROPN B-AC
) PUNCT O
[ PUNCT O
21 NUM O
] PUNCT O
. PUNCT O

The DET O
Gensini PROPN B-LF
Gavito PROPN I-LF
Scale PROPN I-LF
( PUNCT O
GGS PROPN B-AC
) PUNCT O
is AUX O
specifically ADV O
validated VERB O
in ADP O
DRC PROPN O
, PUNCT O
and CCONJ O
was AUX O
used VERB O
to PART O
cross VERB O
- VERB O
validate VERB O
findings NOUN O
on ADP O
early ADJ O
child NOUN O
neurodevelopment NOUN O
, PUNCT O
cognitive ADJ O
ability NOUN O
and CCONJ O
motor NOUN O
development NOUN O
outcomes NOUN O
. PUNCT O

AF PROPN O
– PUNCT O
atrial ADJ O
fibrillation NOUN O
, PUNCT O
AH PROPN B-AC
– PUNCT O
arterial ADJ B-LF
hypertension NOUN I-LF
, PUNCT O
CHD PROPN B-AC
– PUNCT O
coronary ADJ B-LF
heart NOUN I-LF
diseases NOUN I-LF
, PUNCT O
CKD NOUN B-AC
– PUNCT O
chronic ADJ B-LF
kidney NOUN I-LF
disease NOUN I-LF
, PUNCT O
Hb NOUN B-AC
– PUNCT O
hemoglobin NOUN B-LF
. PUNCT O
* PUNCT O
p<0.050 NUM O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
AIC PROPN B-AC
, PUNCT O
Akaike PROPN B-LF
information NOUN I-LF
criterion NOUN I-LF
; PUNCT O
NB PROPN O
, PUNCT O
negative ADJ O
binomial NOUN O
; PUNCT O
Poi PROPN O
, PUNCT O
Poisson PROPN O
; PUNCT O
rhinov NOUN O
, PUNCT O
rhinovirus NOUN O
; PUNCT O
RSV PROPN B-AC
, PUNCT O
respiratory ADJ B-LF
syncytial ADJ I-LF
virus NOUN I-LF
; PUNCT O
temp NOUN O
, PUNCT O
temperature NOUN O

This DET O
analysis NOUN O
aimed VERB O
to PART O
examine VERB O
the DET O
association NOUN O
between ADP O
baseline ADJ O
PNI PROPN B-AC
index NOUN O
and CCONJ O
Overall PROPN B-LF
Survival PROPN I-LF
( PUNCT O
OS PROPN B-AC
) PUNCT O
in ADP O
patients NOUN O
with ADP O
HCC PROPN B-AC
treated VERB O
with ADP O
sorafenib PROPN O
. PUNCT O

ICER PROPN B-AC
= PUNCT O
Incremental ADJ B-LF
cost NOUN I-LF
- PUNCT I-LF
effectiveness NOUN I-LF
ratio NOUN I-LF
. PUNCT O
fFN PROPN B-AC
, PUNCT O
fetal ADJ B-LF
fibronectin NOUN I-LF
; PUNCT O
NMB PROPN B-AC
, PUNCT O
net ADJ B-LF
monetary ADJ I-LF
benefit NOUN I-LF
. PUNCT O

This DET O
experiment NOUN O
is AUX O
representative ADJ O
of ADP O
2 NUM O
independent ADJ O
replicates NOUN O
. PUNCT O
coIP PROPN B-AC
, PUNCT O
co NOUN B-LF
- NOUN I-LF
immunoprecipitation NOUN I-LF
; PUNCT O
IP PROPN O
, PUNCT O
immunoprecipitation NOUN O
. PUNCT O

The DET O
risk NOUN O
of ADP O
developing VERB O
osteoporosis NOUN O
was AUX O
higher ADJ O
in ADP O
the DET O
early ADJ O
H. PROPN O
pylori PROPN O
treatment NOUN O
cohort NOUN O
( PUNCT O
hazard NOUN O
ratio NOUN O
[ X O
HR NOUN O
] X O
= SYM O
1.52 NUM O
, PUNCT O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
[ X O
CI NOUN B-AC
] X O
= SYM O
1.23–1.89 NUM O
) PUNCT O
and CCONJ O
late ADJ O
H. PROPN O
pylori PROPN O
treatment NOUN O
cohort NOUN O
( PUNCT O
HR NOUN O
= SYM O
1.69 NUM O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN B-AC
= SYM O
1.39–2.05 NUM O
) PUNCT O
, PUNCT O
compared VERB O
with ADP O
the DET O
risk NOUN O
in ADP O
the DET O
control ADJ O
cohort NOUN O
. PUNCT O

In ADP O
our PRON O
model NOUN O
, PUNCT O
V1 PROPN O
received VERB O
input NOUN O
from ADP O
lateral ADJ B-LF
geniculate ADJ I-LF
nucleus NOUN I-LF
( PUNCT O
LGN PROPN B-AC
) PUNCT O
relay NOUN O
neurons NOUN O
, PUNCT O
here ADV O
represented VERB O
by ADP O
a DET O
direct ADJ O
current ADJ O
input NOUN O
. PUNCT O

PACE PROPN B-AC
- PUNCT B-AC
Lift NOUN B-AC
, PUNCT O
Pedometer NOUN B-LF
Accelerometer NOUN I-LF
Consultation PROPN I-LF
Evaluation PROPN I-LF
- PUNCT I-LF
Lift NOUN I-LF
; PUNCT O
PACE PROPN B-AC
- PUNCT B-AC
UP PROPN B-AC
, PUNCT O
Pedometer NOUN B-LF
And CCONJ I-LF
Consultation PROPN I-LF
Evaluation PROPN I-LF
- PUNCT I-LF
UP PROPN I-LF
. PUNCT O

AD PROPN B-AC
: PUNCT O
Aguadulce PROPN B-LF
; PUNCT O
LO PROPN B-AC
: PUNCT O
Luz PROPN O
d’Otono PROPN O
; PUNCT O
RM NOUN B-AC
: PUNCT O
Reina PROPN B-LF
Mora PROPN I-LF
. PUNCT O

The DET O
majority NOUN O
of ADP O
patients NOUN O
with ADP O
NAFLD PROPN B-AC
have VERB O
simple ADJ O
steatosis NOUN O
( PUNCT O
non ADJ B-LF
- ADJ I-LF
alcoholic ADJ I-LF
fatty ADJ I-LF
liver NOUN I-LF
, PUNCT O
NAFL PROPN B-AC
) PUNCT O
and CCONJ O
only ADV O
a DET O
minority NOUN O
have VERB O
non ADJ B-LF
- ADJ I-LF
alcoholic ADJ I-LF
steatohepatitis NOUN I-LF
( PUNCT O
NASH PROPN B-AC
) PUNCT O
, PUNCT O
with ADP O
or CCONJ O
without ADP O
fibrosis NOUN O
. PUNCT O

To PART O
satisfy VERB O
all DET O
these DET O
requirements NOUN O
while SCONJ O
maintaining VERB O
high ADJ O
scan NOUN O
time NOUN O
efficiency NOUN O
, PUNCT O
signal NOUN B-LF
- PUNCT I-LF
to PART I-LF
- PUNCT I-LF
noise NOUN I-LF
ratio NOUN I-LF
( PUNCT O
SNR NOUN B-AC
) PUNCT O
and CCONJ O
spatial ADJ O
resolution NOUN O
often ADV O
need VERB O
to PART O
be AUX O
compromised VERB O
when SCONJ O
imaging VERB O
on ADP O
1.5 NUM O
and CCONJ O
3 NUM O
T PROPN O
scanners NOUN O
. PUNCT O

Changes NOUN O
in ADP O
renal ADJ O
haemodynamics NOUN O
are AUX O
believed VERB O
to ADP O
be AUX O
primarily ADV O
related VERB O
to ADP O
the DET O
increased ADJ O
estimated VERB B-LF
glomerular ADJ I-LF
filtration NOUN I-LF
rate NOUN I-LF
( PUNCT O
eGFR NOUN B-AC
) PUNCT O
towards ADP O
the DET O
hyperfiltration NOUN O
state NOUN O
in ADP O
addition NOUN O
to ADP O
a DET O
presence NOUN O
of ADP O
increased ADJ O
filtration NOUN O
fraction NOUN O
[ PUNCT O
39,40 NUM O
] PUNCT O
. PUNCT O

The DET O
larvae NOUN O
have VERB O
fluorescent ADJ O
macrophages NOUN O
( PUNCT O
red ADJ O
) PUNCT O
and CCONJ O
were AUX O
injected VERB O
with ADP O
fluorescent ADJ O
S. PROPN O
aureus PROPN O
( PUNCT O
green ADJ O
) PUNCT O
and/or CCONJ O
fluorescently ADV O
labelled VERB O
M. PROPN O
luteus PROPN O
PGN PROPN B-AC
( PUNCT O
blue ADJ O
) PUNCT O
G NOUN O
- NOUN O
I NOUN O
Images NOUN O
of ADP O
infected ADJ O
larvae NOUN O
at ADP O
2 NUM O
hpi NOUN B-AC
showing VERB O
macrophages NOUN O
containing VERB O
S. PROPN O
aureus PROPN O
, PUNCT O
scale NOUN O
6.9 NUM O
μm NOUN O
, PUNCT O
greyscale NOUN O
insets NOUN O
depict VERB O
location NOUN O
of ADP O
fluorescence NOUN O
signal NOUN O
within ADP O
the DET O
hatched VERB O
box NOUN O
of ADP O
the DET O
main ADJ O
image NOUN O
, PUNCT O
for ADP O
ease NOUN O
of ADP O
visualisation NOUN O
( PUNCT O
G NOUN O
) PUNCT O
, PUNCT O
M. PROPN O
luteus PROPN O
peptidoglycan NOUN B-LF
scale NOUN O
6.9 NUM O
μm NOUN O
( PUNCT O
H NOUN O
) PUNCT O
, PUNCT O
or CCONJ O
both PRON O
scale NOUN O
10 NUM O
μm NOUN O
( PUNCT O
I NOUN O
) PUNCT O
, PUNCT O
J PROPN O
Area NOUN O
of ADP O
macrophage NOUN O
taken VERB O
up ADP O
by ADP O
S. PROPN O
aureus PROPN O
at ADP O
2 NUM O
hpi NOUN B-AC
( PUNCT O
n NOUN O
= SYM O
3 NUM O
, PUNCT O
14–21 NUM O
larvae NOUN O
per ADP O
group NOUN O
, PUNCT O
unpaired ADJ O
t NOUN O
- NOUN O
test NOUN O
) PUNCT O
K NOUN O
Area NOUN O
of ADP O
macrophage NOUN O
taken VERB O
up ADP O
by ADP O
M. PROPN O
luteus PROPN O
PGN PROPN B-AC
at ADP O
2hpi NUM O
( PUNCT O
n NOUN O
= SYM O
3 NUM O
, PUNCT O
11–21 NUM O
larvae NOUN O
per ADP O
group NOUN O
, PUNCT O
two NUM O
- NOUN O
tailed ADJ O
unpaired ADJ O
t NOUN O
- NOUN O
test NOUN O
, PUNCT O
* PUNCT O
* PUNCT O
* PUNCT O
p<0.0004 NUM O
) PUNCT O
. PUNCT O

There PRON O
were VERB O
increases NOUN O
in ADP O
both CCONJ O
lower ADJ O
and CCONJ O
upper ADJ O
normal ADJ O
limits NOUN O
for ADP O
blood NOUN O
neutrophil NOUN O
, PUNCT O
thyroid NOUN O
profile NOUN O
( PUNCT O
triiodothyronine NOUN B-LF
( PUNCT O
T3 NOUN B-AC
) PUNCT O
and CCONJ O
thyroxine NOUN B-LF
( PUNCT O
T4 NOUN B-AC
) PUNCT O
) PUNCT O
, PUNCT O
testosterone NOUN O
, PUNCT O
estradiol NOUN O
, PUNCT O
and CCONJ O
progesterone NOUN O
and CCONJ O
decreases NOUN O
for ADP O
RBC NOUN B-AC
, PUNCT O
hemoglobin NOUN O
( PUNCT O
Hb NOUN O
) PUNCT O
, PUNCT O
alanine NOUN B-LF
aminotransferase NOUN I-LF
( PUNCT O
ALT NOUN B-AC
) PUNCT O
and CCONJ O
creatinine NOUN B-LF
( PUNCT O
Cr NOUN B-AC
) PUNCT O
during ADP O
their PRON O
third ADJ O
trimesters NOUN O
. PUNCT O

High ADJ O
- NOUN O
molecular ADJ O
- NOUN O
weight NOUN O
PLA PROPN B-AC
is AUX O
mainly ADV O
synthesized VERB O
through ADP O
the DET O
ring NOUN B-LF
- NOUN I-LF
opening VERB I-LF
polymerization NOUN I-LF
( PUNCT O
ROP NOUN B-AC
) PUNCT O
of ADP O
D PROPN O
, PUNCT O
L NOUN O
- NOUN O
lactide NOUN O
or CCONJ O
L NOUN O
- NOUN O
lactide NOUN O
catalyzed VERB O
by ADP O
coordination NOUN O
compounds NOUN O
[ X O
1–4 NUM O
] PUNCT O
. PUNCT O

The DET O
automated VERB O
annotation NOUN O
programs NOUN O
failed VERB O
to PART O
identify VERB O
VRI PROPN B-AC
, PUNCT O
PDP1 PROPN B-AC
and CCONJ O
PER PROPN B-AC
among ADP O
the DET O
L. PROPN O
madurae PROPN O
transcripts NOUN B-LF
with ADP I-LF
coding VERB I-LF
regions NOUN I-LF
( PUNCT O
CDS PROPN B-AC
) PUNCT O
. PUNCT O
These DET O
results NOUN O
underscore VERB O
the DET O
value NOUN O
of ADP O
targeted VERB O
gene NOUN O
discovery NOUN O
in ADP O
combination NOUN O
with ADP O
the DET O
automated VERB O
bioinformatics NOUN O
tools NOUN O
to PART O
obtain VERB O
a DET O
complete ADJ O
annotation NOUN O
for ADP O
a DET O
de X O
novo X O
transcriptome NOUN O
. PUNCT O

Central ADJ B-LF
nervous ADJ I-LF
system NOUN I-LF
( PUNCT O
CNS PROPN B-AC
) PUNCT O
and CCONJ O
urinary ADJ O
tract NOUN O
abnormalities NOUN O
are AUX O
common ADJ O
human ADJ O
malformations NOUN O
, PUNCT O
but CCONJ O
their PRON O
variability NOUN O
and CCONJ O
genetic ADJ O
complexity NOUN O
make VERB O
it PRON O
difficult ADJ O
to PART O
identify VERB O
the DET O
responsible ADJ O
genes NOUN O
. PUNCT O

Human ADJ B-LF
endogenous ADJ I-LF
retroviruses NOUN I-LF
( PUNCT O
HERVs NOUN B-AC
) PUNCT O
are AUX O
remnants NOUN O
of ADP O
ancient ADJ O
infectious ADJ O
agents NOUN O
that PRON O
have AUX O
integrated VERB O
into ADP O
the DET O
human ADJ O
genome NOUN O
. PUNCT O

The DET O
in ADP O
vitro X O
study NOUN O
was AUX O
conducted VERB O
in ADP O
a DET O
2 NUM O
( PUNCT O
infection NOUN O
status NOUN O
; PUNCT O
non ADJ O
- ADJ O
infected ADJ B-LF
versus ADP O
infected ADJ B-LF
) PUNCT O
× SYM O
3 NUM O
( PUNCT O
diets NOUN O
; PUNCT O
control NOUN O
, PUNCT O
Mix1 NOUN B-AC
and CCONJ O
Mix2 NOUN B-AC
) PUNCT O
factorial ADJ O
design NOUN O
. PUNCT O

The DET O
raw ADJ O
images NOUN O
for ADP O
D PROPN O
can AUX O
be AUX O
found VERB O
in ADP O
S1 PROPN O
Raw PROPN O
Images PROPN O
. PUNCT O
dpi NOUN B-AC
, PUNCT O
days NOUN B-LF
post NOUN I-LF
- PUNCT I-LF
infection NOUN I-LF
; PUNCT O
ORF NOUN B-AC
, PUNCT O
open ADJ B-LF
reading NOUN I-LF
frame NOUN I-LF
; PUNCT O
RT NOUN B-AC
- PUNCT B-AC
PCR NOUN B-AC
, PUNCT O
reverse ADJ B-LF
transcription NOUN I-LF
PCR NOUN I-LF
; PUNCT O
SARS PROPN B-AC
- PUNCT B-AC
CoV-2 PROPN B-AC
, PUNCT O
Severe PROPN B-LF
Acute PROPN I-LF
Respiratory PROPN I-LF
Syndrome PROPN I-LF
Coronavirus PROPN I-LF
2 NUM I-LF
; PUNCT O
scRNA NOUN O
- PUNCT O
seq NOUN O
, PUNCT O
single ADJ O
- PUNCT O
cell NOUN O
RNA NOUN O
sequencing NOUN O
; PUNCT O
sgRNA NOUN B-AC
, PUNCT O
subgenomic ADJ B-LF
RNA NOUN I-LF
. PUNCT O

Bacteria NOUN O
contain VERB O
eight NUM O
lineages NOUN O
of ADP O
mobile ADJ O
group NOUN O
II NUM O
introns NOUN O
, PUNCT O
which PRON O
are AUX O
distinguished VERB O
by ADP O
different ADJ O
IEP PROPN B-AC
types NOUN O
( PUNCT O
bacterial ADJ O
A NOUN O
– SYM O
F PROPN O
, PUNCT O
mitochondrial ADJ B-LF
- PUNCT I-LF
like ADJ I-LF
( PUNCT O
ML PROPN B-AC
) PUNCT O
and CCONJ O
chloroplast NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
( PUNCT O
CL NOUN B-AC
) PUNCT O
) PUNCT O
and CCONJ O
distinct ADJ O
RNA NOUN O
structural ADJ O
subgroups NOUN O
( PUNCT O
IIA PROPN O
( PUNCT O
ML PROPN B-AC
) PUNCT O
, PUNCT O
IIB PROPN O
( PUNCT O
CL NOUN B-AC
and CCONJ O
bacterial ADJ O
lineages NOUN O
A NOUN O
, PUNCT O
B PROPN O
, PUNCT O
and CCONJ O
D PROPN O
– SYM O
F PROPN O
) PUNCT O
, PUNCT O
and CCONJ O
IIC PROPN O
( PUNCT O
bacterial ADJ O
lineage NOUN O
C NOUN O
) PUNCT O
) PUNCT O
[ PUNCT O
18 NUM O
] PUNCT O
. PUNCT O

WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
; PUNCT O
YFP PROPN B-AC
, PUNCT O
yellow ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
. PUNCT O

ANC PROPN B-AC
, PUNCT O
antenatal ADJ B-LF
care NOUN I-LF
. PUNCT O

Jumonji PROPN B-LF
domain NOUN I-LF
- PUNCT I-LF
containing VERB I-LF
6 NUM I-LF
( PUNCT O
JMJD6 PROPN B-AC
) PUNCT O
is AUX O
a DET O
member NOUN O
of ADP O
the DET O
Jumonji PROPN O
C PROPN O
domain NOUN O
- PUNCT O
containing VERB O
family NOUN O
of ADP O
proteins NOUN O
. PUNCT O

HOMA PROPN B-AC
- PUNCT B-AC
IR PROPN B-AC
, PUNCT O
homeostasis NOUN B-LF
model NOUN I-LF
assessment NOUN I-LF
of ADP I-LF
insulin NOUN I-LF
resistance NOUN I-LF
. PUNCT O

CRLM NOUN O
: PUNCT O
colorectal ADJ O
liver NOUN O
metastases NOUN O
; PUNCT O
iCCA NOUN B-AC
: PUNCT O
intrahepatic ADJ B-LF
cholangiocarcinoma NOUN I-LF
; PUNCT O
pCCA NOUN B-AC
: PUNCT O
perihilar ADJ B-LF
cholangiocarcinoma NOUN I-LF
; PUNCT O
HCC NOUN B-AC
: PUNCT O
hepatocellular ADJ B-LF
carcinoma NOUN I-LF
. PUNCT O

Intravoxel NOUN B-LF
incoherent ADJ I-LF
motion NOUN I-LF
( PUNCT O
IVIM PROPN B-AC
) PUNCT O
imaging NOUN O
concurrently ADV O
measures VERB O
diffusion NOUN O
and CCONJ O
perfusion NOUN O
parameters NOUN O
and CCONJ O
has VERB O
potential ADJ O
applications NOUN O
for ADP O
brain NOUN O
tumor NOUN O
classification NOUN O
. PUNCT O

We PRON O
also ADV O
used VERB O
multivariable ADJ B-LF
MR NOUN I-LF
( PUNCT O
MVMR PROPN B-AC
) PUNCT O
as ADP O
a DET O
sensitivity NOUN O
analysis NOUN O
to PART O
adjust VERB O
for ADP O
C NOUN B-LF
- PUNCT I-LF
reactive ADJ I-LF
protein NOUN I-LF
( PUNCT O
CRP PROPN B-AC
) PUNCT O
, PUNCT O
an DET O
archetypal ADJ O
inflammatory ADJ O
marker NOUN O
, PUNCT O
as ADP O
a DET O
general ADJ O
downstream ADJ O
marker NOUN O
of ADP O
systemic ADJ O
inflammation NOUN O
. PUNCT O

The DET O
zoonotic ADJ O
coronavirus NOUN O
Severe PROPN B-LF
Acute PROPN I-LF
Respiratory PROPN I-LF
Syndrome PROPN I-LF
Coronavirus PROPN I-LF
2 NUM I-LF
( PUNCT O
SARS PROPN B-AC
- PUNCT B-AC
CoV-2 PROPN B-AC
) PUNCT O
first ADV O
emerged VERB O
in ADP O
Wuhan PROPN O
, PUNCT O
Hubei PROPN O
Province PROPN O
, PUNCT O
China PROPN O
, PUNCT O
in ADP O
December PROPN O
2019 NUM O
and CCONJ O
was AUX O
soon ADV O
recognized VERB O
as ADP O
the DET O
etiological ADJ O
agent NOUN O
of ADP O
Coronavirus PROPN B-LF
Disease PROPN I-LF
2019 NUM I-LF
( PUNCT O
COVID-19 PROPN B-AC
) PUNCT O
. PUNCT O

IVW PROPN O
, PUNCT O
inverse NOUN O
- PUNCT O
variance NOUN O
weighted VERB O
; PUNCT O
MR PROPN B-AC
, PUNCT O
Mendelian ADJ B-LF
randomization NOUN I-LF
; PUNCT O
OR PROPN B-AC
, PUNCT O
odds NOUN B-LF
ratio NOUN I-LF
. PUNCT O

The DET O
following VERB O
formula NOUN O
was AUX O
used VERB O
to ADP O
obtain VERB O
an DET O
approximate ADJ O
odds NOUN B-LF
ratio NOUN I-LF
( PUNCT O
OR NOUN B-AC
) PUNCT O
of ADP O
the DET O
effect NOUN O
of ADP O
BMI PROPN B-AC
on ADP O
psoriasis NOUN O
, PUNCT O
as SCONJ O
previously ADV O
demonstrated VERB O
by ADP O
Perry PROPN O
and CCONJ O
colleagues NOUN O
[ X O
17 NUM O
] X O
: PUNCT O
OR NOUN B-AC
= SYM O
exp(1.81×[SD×SMD NOUN B-AC
] X O
) PUNCT O
such ADJ O
that SCONJ O
SD NOUN B-AC
is AUX O
the DET O
standard ADJ B-LF
deviation NOUN I-LF
increase NOUN O
in ADP O
BMI PROPN B-AC
per ADP O
SD NOUN B-AC
change NOUN O
in ADP O
the DET O
BMI PROPN B-AC
genetic ADJ O
instrument NOUN O
( PUNCT O
genetic ADJ B-LF
risk NOUN I-LF
score NOUN I-LF
[ X O
GRS PROPN B-AC
] X O
) PUNCT O
, PUNCT O
SMD NOUN B-AC
is AUX O
the DET O
standardized ADJ B-LF
mean ADJ I-LF
difference NOUN I-LF
, PUNCT O
and CCONJ O
1.81 NUM O
is AUX O
the DET O
scaling VERB O
factor NOUN O
used VERB O
to ADP O
convert VERB O
SMDs NOUN B-AC
to ADP O
ln(ORs NOUN B-AC
) PUNCT O
[ X O
18,19 X O
] X O
( PUNCT O
S1 PROPN O
Appendix NOUN O
Supporting NOUN O
Text PROPN O
A NOUN O
) PUNCT O
. PUNCT O

Top NOUN B-LF
of ADP I-LF
SF NOUN I-LF
or CCONJ I-LF
AS NOUN I-LF

To PART O
determine VERB O
the DET O
precise ADJ O
identity NOUN O
of ADP O
X1 NOUN O
fraction NOUN O
, PUNCT O
we PRON O
executed VERB O
mass NOUN B-LF
spectrometry NOUN I-LF
( PUNCT O
MS PROPN B-AC
) PUNCT O
analysis NOUN O
, PUNCT O
which PRON O
revealed VERB O
certain ADJ O
PEtn PROPN B-AC
- PUNCT B-AC
Cer PROPN B-AC
and CCONJ O
PtdSer PROPN B-AC
species NOUN O
, PUNCT O
as SCONJ O
expected VERB O
( PUNCT O
Fig PROPN O
1B NUM O
) PUNCT O
. PUNCT O
The DET O
most ADV O
prominent ADJ O
peak NOUN O
in ADP O
this DET O
fraction NOUN O
with ADP O
an DET O
m NOUN O
/ SYM O
z NOUN O
of ADP O
850.5 NUM O
, PUNCT O
however ADV O
, PUNCT O
did AUX O
not PART O
correspond VERB O
to ADP O
a DET O
PEtn PROPN B-AC
- PUNCT B-AC
Cer PROPN B-AC
or CCONJ O
PtdSer PROPN B-AC
species NOUN O
. PUNCT O

Accordingly ADV O
, PUNCT O
step NOUN B-LF
width NOUN I-LF
variability NOUN I-LF
( PUNCT O
SWV PROPN B-AC
) PUNCT O
and CCONJ O
step NOUN B-LF
length NOUN I-LF
variability NOUN I-LF
( PUNCT O
SLV NOUN B-AC
) PUNCT O
are AUX O
generally ADV O
considered VERB O
markers NOUN O
of ADP O
reduced VERB O
walking NOUN O
balance NOUN O
integrity NOUN O
. PUNCT O

The DET O
coronavirus NOUN B-LF
disease NOUN I-LF
2019 NUM I-LF
( PUNCT O
COVID-19 NOUN B-AC
) PUNCT O
has AUX O
become VERB O
a DET O
worst ADJ O
pandemic NOUN O
. PUNCT O

Water NOUN O
vapor NOUN O
prevents VERB O
temperature NOUN O
from ADP O
increasing VERB O
with ADP O
VOCs NOUN B-AC
adsorption NOUN O
equilibria NOUN O
; PUNCT O
when SCONJ O
the DET O
relative ADJ B-LF
humidity NOUN I-LF
( PUNCT O
RH NOUN B-AC
) PUNCT O
increases NOUN O
, PUNCT O
the DET O
adsorption NOUN O
of ADP O
VOCs NOUN B-AC
by ADP O
building NOUN O
materials NOUN O
decreases VERB O
, PUNCT O
but CCONJ O
it PRON O
increases NOUN O
with ADP O
polarity NOUN O
increases NOUN O
in ADP O
VOC NOUN O
molecules NOUN O
[ X O
6,7 NUM O
] PUNCT O
. PUNCT O

SDFR PROPN B-AC
rates NOUN O
increased VERB O
after ADP O
introduction NOUN O
of ADP O
treat NOUN O
- PUNCT O
to PART O
- PUNCT O
target NOUN O
( PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
[ PUNCT O
HR PROPN B-AC
] PUNCT O
2006–2010 NUM O
relative ADJ O
to PART O
1993–1996 NUM O
: PUNCT O
3.35 NUM O
[ PUNCT O
95 NUM O
% NOUN O
CI NOUN O
1.46 NUM O
to PART O
7.72 NUM O
; PUNCT O
p NOUN O
= SYM O
0.004 NUM O
] PUNCT O
; PUNCT O
HR PROPN B-AC
2011–2016 NUM O
: PUNCT O
4.57 NUM O
[ PUNCT O
95 NUM O
% NOUN O
CI NOUN O
1.80 NUM O
to PART O
11.6 NUM O
; PUNCT O
p NOUN O
= SYM O
0.001 NUM O
] PUNCT O
) PUNCT O
in ADP O
autoantibody NOUN O
- PUNCT O
positive ADJ O
RA NOUN B-AC
, PUNCT O
but CCONJ O
not PART O
in ADP O
autoantibody NOUN O
- PUNCT O
negative ADJ O
RA NOUN B-AC
. PUNCT O
In ADP O
autoantibody NOUN O
- PUNCT O
positive ADJ O
RA NOUN B-AC
, PUNCT O
mortality NOUN O
decreased VERB O
significantly ADV O
after ADP O
the DET O
introduction NOUN O
of ADP O
treat NOUN O
- PUNCT O
to PART O
- PUNCT O
target NOUN O
treatment NOUN O
adjustments NOUN O
( PUNCT O
HR PROPN B-AC
2006–2010 NUM O
: PUNCT O
0.56 NUM O
[ PUNCT O
95 NUM O
% NOUN O
CI NOUN O
0.34 NUM O
to PART O
0.92 NUM O
; PUNCT O
p NOUN O
= SYM O
0.023 NUM O
] PUNCT O
; PUNCT O
HR PROPN B-AC
2011–2016 NUM O
: PUNCT O
0.33 NUM O
[ PUNCT O
95 NUM O
% NOUN O
CI NOUN O
0.14 NUM O
to PART O
0.77 NUM O
; PUNCT O
p NOUN O
= SYM O
0.010 NUM O
] PUNCT O
) PUNCT O
, PUNCT O
but CCONJ O
not PART O
in ADP O
autoantibody NOUN O
- PUNCT O
negative ADJ O
RA NOUN B-AC
( PUNCT O
HR PROPN B-AC
2006–2010 NUM O
: PUNCT O
0.79 NUM O
[ PUNCT O
95 NUM O
% NOUN O
CI NOUN O
0.40 NUM O
to PART O
1.56 NUM O
; PUNCT O
p NOUN O
= SYM O
0.50 NUM O
] PUNCT O
; PUNCT O
HR PROPN B-AC
2011–2016 NUM O
: PUNCT O
0.36 NUM O
[ PUNCT O
95 NUM O
% NOUN O
CI NOUN O
0.10 NUM O
to PART O
1.34 NUM O
; PUNCT O
p NOUN O
= SYM O
0.13 NUM O
] PUNCT O
) PUNCT O
. PUNCT O

Ethical ADJ O
approval NOUN O
was AUX O
obtained VERB O
from ADP O
the DET O
Uganda PROPN B-LF
National PROPN I-LF
Council PROPN I-LF
of ADP I-LF
Science PROPN I-LF
and CCONJ I-LF
Technology PROPN I-LF
( PUNCT O
UNCST PROPN B-AC
) PUNCT O
on ADP O
20th NUM O
December PROPN O
2010 NUM O
and CCONJ O
an DET O
extension NOUN O
for ADP O
the DET O
study NOUN O
granted VERB O
on ADP O
11th ADJ O
November PROPN O
2011 NUM O
. PUNCT O

GPC PROPN B-AC
, PUNCT O
Global PROPN B-LF
Prokaryotic PROPN I-LF
Census PROPN I-LF
. PUNCT O

PRESENILIN PROPN B-LF
2 NUM I-LF
( PUNCT O
PSEN2 PROPN B-AC
) PUNCT O
is AUX O
one NUM O
of ADP O
the DET O
genes NOUN O
mutated VERB O
in ADP O
early ADJ B-LF
onset NOUN I-LF
familial ADJ I-LF
Alzheimer PROPN I-LF
’s PART I-LF
disease NOUN I-LF
( PUNCT O
EOfAD PROPN B-AC
) PUNCT O
. PUNCT O
PSEN2 PROPN B-AC
shares VERB O
significant ADJ O
amino NOUN O
acid NOUN O
sequence NOUN O
identity NOUN O
with ADP O
another DET O
EOfAD PROPN B-AC
- PUNCT O
related VERB O
gene NOUN O
PRESENILIN PROPN B-LF
1 NUM I-LF
( PUNCT O
PSEN1 PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
partial ADJ O
functional ADJ O
redundancy NOUN O
is AUX O
seen VERB O
between ADP O
these DET O
two NUM O
genes NOUN O
. PUNCT O

For ADP O
Cisplatin PROPN O
, PUNCT O
Docetaxel PROPN O
, PUNCT O
Doxorubicin PROPN O
, PUNCT O
and CCONJ O
Etoposide PROPN O
, PUNCT O
the DET O
best ADV O
performance NOUN O
was AUX O
attained VERB O
for ADP O
+ NOUN O
-5%c NOUN O
and CCONJ O
+ NOUN O
-10%c NOUN O
, PUNCT O
and CCONJ O
the DET O
best ADV O
- PUNCT O
performing VERB O
algorithms NOUN O
were AUX O
always ADV O
SVM PROPN B-AC
or CCONJ O
Random PROPN B-LF
Forests PROPN I-LF
( PUNCT O
RF PROPN B-AC
) PUNCT O
( PUNCT O
S1 PROPN O
– SYM O
S7 NUM O
Tables PROPN O
) PUNCT O
. PUNCT O

DOT PROPN B-AC
, PUNCT O
directly ADV B-LF
observed VERB I-LF
therapy NOUN I-LF
; PUNCT O
SAT PROPN B-AC
, PUNCT O
self NOUN B-LF
- PUNCT I-LF
administered VERB I-LF
therapy NOUN I-LF
; PUNCT O
TB PROPN B-AC
, PUNCT O
tuberculosis NOUN B-LF
. PUNCT O

To PART O
define VERB O
the DET O
aldesleukin NOUN O
dose NOUN O
response NOUN O
for ADP O
Tregs NOUN B-AC
and CCONJ O
to PART O
find VERB O
doses NOUN O
that PRON O
increase VERB O
Tregs NOUN B-AC
physiologically ADV O
for ADP O
treatment NOUN O
of ADP O
T1D PROPN B-AC
, PUNCT O
a DET O
statistical ADJ O
and CCONJ O
systematic ADJ O
approach NOUN O
was AUX O
taken VERB O
by ADP O
analysing VERB O
the DET O
pharmacokinetics NOUN O
and CCONJ O
pharmacodynamics NOUN O
of ADP O
single ADJ O
doses NOUN O
of ADP O
subcutaneous ADJ O
aldesleukin NOUN O
in ADP O
the DET O
Adaptive PROPN B-LF
Study PROPN I-LF
of ADP I-LF
IL-2 PROPN I-LF
Dose PROPN I-LF
on ADP I-LF
Regulatory PROPN I-LF
T PROPN I-LF
Cells PROPN I-LF
in ADP I-LF
Type PROPN I-LF
1 NUM I-LF
Diabetes PROPN I-LF
( PUNCT O
DILT1D PROPN B-AC
) PUNCT O
, PUNCT O
a DET O
single ADJ O
centre NOUN O
, PUNCT O
non ADJ O
- PUNCT O
randomised ADJ O
, PUNCT O
open ADJ O
label NOUN O
, PUNCT O
adaptive ADJ O
dose NOUN O
- PUNCT O
finding VERB O
trial NOUN O
with ADP O
40 NUM O
adult NOUN O
participants NOUN O
with ADP O
recently ADV O
diagnosed VERB O
T1D. NOUN B-AC

Standard ADJ B-LF
deviation NOUN I-LF
( PUNCT O
SD NOUN B-AC
) PUNCT O
in ADP O
parantheses NOUN O
. PUNCT O

Other ADJ O
abbreviations NOUN O
: PUNCT O
ISOpull PROPN B-AC
, PUNCT O
isometric ADJ B-LF
pulls NOUN I-LF
; PUNCT O
MVIC PROPN O
, PUNCT O
maximal ADJ O
voluntary ADJ O
isometric ADJ O
contraction NOUN O
; PUNCT O
reps NOUN O
, PUNCT O
repetitions NOUN O
; PUNCT O
RM PROPN B-AC
, PUNCT O
repetition NOUN B-LF
maximum ADJ I-LF
; PUNCT O
ROM PROPN B-AC
, PUNCT O
range NOUN B-LF
of ADP I-LF
motion NOUN I-LF
. PUNCT O

Abbreviations NOUN O
; PUNCT O
TD PROPN B-AC
- PUNCT B-AC
MET PROPN B-AC
, PUNCT O
metastatic ADJ B-LF
tumor NOUN I-LF
diameter NOUN I-LF
; PUNCT O
AVI PROPN B-AC
, PUNCT O
afferent ADJ B-LF
vascular ADJ I-LF
invasion NOUN I-LF
; PUNCT O
EVI PROPN B-AC
, PUNCT O
efferent ADJ B-LF
vascular ADJ I-LF
invasion NOUN I-LF
. PUNCT O

Therefore ADV O
, PUNCT O
the DET O
primary ADJ O
analyses NOUN O
employed VERB O
logistic NOUN O
regression NOUN O
to ADP O
estimate VERB O
adjusted VERB O
odds NOUN B-LF
ratios NOUN I-LF
( PUNCT O
ORs NOUN B-AC
) PUNCT O
and CCONJ O
95 NUM O
% NOUN O
confidence NOUN B-LF
intervals NOUN I-LF
( PUNCT O
CIs NOUN B-AC
) PUNCT O
for ADP O
the DET O
first ADJ O
event NOUN O
of ADP O
the DET O
outcomes NOUN O
of ADP O
interest NOUN O
( PUNCT O
as ADP O
a DET O
binary ADJ O
endpoint NOUN O
, PUNCT O
ignoring VERB O
the DET O
time NOUN O
- PUNCT O
to ADP O
- PUNCT O
event NOUN O
) PUNCT O
. PUNCT O

Somatic ADJ O
genetic ADJ O
CDKN2A PROPN O
, PUNCT O
TP53 PROPN O
, PUNCT O
and CCONJ O
DNA NOUN O
content NOUN O
abnormalities NOUN O
are AUX O
common ADJ O
in ADP O
many ADJ O
human ADJ O
cancers NOUN O
and CCONJ O
their PRON O
precursors NOUN O
, PUNCT O
including VERB O
esophageal ADJ B-LF
adenocarcinoma NOUN I-LF
( PUNCT O
EA PROPN B-AC
) PUNCT O
and CCONJ O
Barrett PROPN B-LF
's PART I-LF
esophagus NOUN I-LF
( PUNCT O
BE PROPN B-AC
) PUNCT O
, PUNCT O
conditions NOUN O
for ADP O
which PRON O
aspirin NOUN O
and CCONJ O
other ADJ O
nonsteroidal ADJ B-LF
anti ADJ I-LF
- ADJ I-LF
inflammatory ADJ I-LF
drugs NOUN I-LF
( PUNCT O
NSAIDs PROPN B-AC
) PUNCT O
have AUX O
been AUX O
proposed VERB O
as ADP O
possible ADJ O
chemopreventive ADJ O
agents NOUN O
; PUNCT O
however ADV O
, PUNCT O
little ADJ O
is AUX O
known VERB O
about ADP O
the DET O
ability NOUN O
of ADP O
a DET O
biomarker NOUN O
panel NOUN O
to ADP O
predict VERB O
progression NOUN O
to ADP O
cancer NOUN O
nor CCONJ O
how SCONJ O
NSAID PROPN B-AC
use NOUN O
may AUX O
modulate VERB O
progression NOUN O
. PUNCT O

The DET O
ARROW PROPN B-AC
trial NOUN O
's PART O
primary ADJ O
aim NOUN O
was AUX O
to ADP O
compare VERB O
two NUM O
monitoring NOUN O
strategies NOUN O
in ADP O
children NOUN O
starting VERB O
ART PROPN B-AC
. PUNCT O
Accordingly ADV O
, PUNCT O
children NOUN O
were AUX O
randomised VERB O
to ADP O
either CCONJ O
the DET O
“ PUNCT O
clinically ADV B-LF
driven VERB I-LF
monitoring NOUN I-LF
” PUNCT O
( PUNCT O
CDM PROPN B-AC
) PUNCT O
or CCONJ O
“ PUNCT O
laboratory ADJ B-LF
and CCONJ I-LF
clinical ADJ I-LF
monitoring NOUN I-LF
” PUNCT O
( PUNCT O
LCM PROPN B-AC
) PUNCT O
group NOUN O
. PUNCT O

For ADP O
continuous ADJ O
variables NOUN O
, PUNCT O
the DET O
mean NOUN O
and CCONJ O
standard ADJ B-LF
deviation NOUN I-LF
( PUNCT O
SD NOUN B-AC
) PUNCT O
of ADP O
WC PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT O
BMI PROPN B-AC
) PUNCT O
, PUNCT O
TG PROPN B-AC
, PUNCT O
HDL PROPN B-AC
- PUNCT B-AC
C PROPN B-AC
, PUNCT O
FBG PROPN B-AC
, PUNCT O
systolic ADJ O
BP PROPN B-AC
, PUNCT O
and CCONJ O
diastolic ADJ O
BP PROPN B-AC
for ADP O
HBsAg PROPN B-AC
positive ADJ O
subjects NOUN O
and CCONJ O
the DET O
controls NOUN O
were AUX O
extracted VERB O
. PUNCT O

These DET O
proteins NOUN O
bind VERB O
sequentially ADV O
to ADP O
the DET O
translocase NOUN B-LF
of ADP I-LF
the DET I-LF
outer ADJ I-LF
membrane NOUN I-LF
( PUNCT O
TOM PROPN B-AC
) PUNCT O
complex NOUN O
situated VERB O
in ADP O
the DET O
outer ADJ B-LF
mitochondrial ADJ I-LF
membrane NOUN I-LF
( PUNCT O
OMM PROPN B-AC
) PUNCT O
and CCONJ O
then ADV O
to ADP O
the DET O
translocase NOUN B-LF
of ADP I-LF
the DET I-LF
inner ADJ I-LF
membrane NOUN I-LF
23 NUM I-LF
( PUNCT O
TIM23 PROPN B-AC
) PUNCT O
complex NOUN O
. PUNCT O

Uncoupling VERB B-LF
protein NOUN I-LF
1 NUM I-LF
( PUNCT O
UCP1 PROPN B-AC
) PUNCT O
is AUX O
exclusively ADV O
expressed VERB O
in ADP O
BAT PROPN B-AC
and CCONJ O
is AUX O
localized VERB O
to ADP O
the DET O
inner ADJ O
membrane NOUN O
of ADP O
the DET O
mitochondria NOUN O
. PUNCT O

TPM PROPN B-AC
, PUNCT O
transcripts NOUN B-LF
per ADP I-LF
million NUM I-LF
. PUNCT O

The DET O
project NOUN O
aims VERB O
to PART O
resolve VERB O
the DET O
technical ADJ O
, PUNCT O
social ADJ O
and CCONJ O
economic ADJ O
bottlenecks NOUN O
for ADP O
PMF PROPN B-AC
. PUNCT O
It PRON O
takes VERB O
a DET O
product NOUN O
- PUNCT O
led VERB O
approach NOUN O
with ADP O
five NUM O
small ADJ B-LF
to PART I-LF
medium ADJ I-LF
enterprises NOUN I-LF
( PUNCT O
SMEs PROPN B-AC
) PUNCT O
involved VERB O
in ADP O
the DET O
production NOUN O
of ADP O
medical ADJ O
, PUNCT O
veterinary ADJ O
and CCONJ O
diagnostic ADJ O
products NOUN O
— PUNCT O
it PRON O
also ADV O
aims VERB O
to PART O
involve VERB O
all DET O
relevant ADJ O
stakeholders NOUN O
in ADP O
the DET O
process NOUN O
of ADP O
developing VERB O
these DET O
platforms NOUN O
, PUNCT O
including VERB O
scientists NOUN O
, PUNCT O
representatives NOUN O
of ADP O
PMF PROPN B-AC
businesses NOUN O
and CCONJ O
the DET O
public NOUN O
at ADP O
large ADJ O
. PUNCT O

Pre ADJ O
- ADJ O
procedural ADJ O
anticoagulation NOUN O
was AUX O
performed VERB O
with ADP O
either CCONJ O
warfarin NOUN O
or CCONJ O
non ADJ B-LF
- ADJ I-LF
vitamin ADJ I-LF
K NOUN I-LF
oral ADJ I-LF
anticoagulant NOUN I-LF
( PUNCT O
NOAC PROPN B-AC
) PUNCT O
. PUNCT O
Some DET O
patient NOUN O
was AUX O
not PART O
prescribed VERB O
with ADP O
anticoagulants NOUN O
. PUNCT O

After ADP O
solid ADJ O
organ NOUN O
transplantation NOUN O
, PUNCT O
the DET O
production NOUN O
of ADP O
donor NOUN B-LF
- NOUN I-LF
specific ADJ I-LF
allo NOUN I-LF
- NOUN I-LF
antibodies NOUN I-LF
( PUNCT O
DSA PROPN B-AC
) PUNCT O
is AUX O
involved VERB O
in ADP O
both CCONJ O
acute ADJ O
and CCONJ O
chronic ADJ O
allograft NOUN O
rejection NOUN O
[ PUNCT O
3 NUM O
, PUNCT O
4 NUM O
] PUNCT O
. PUNCT O

Preadipocyte ADJ O
expression NOUN O
of ADP O
the DET O
angiogenic ADJ O
genes NOUN O
vascular ADJ B-LF
endothelial ADJ I-LF
growth NOUN I-LF
factor NOUN I-LF
( PUNCT O
VEGF PROPN B-AC
) PUNCT O
and CCONJ O
nuclear ADJ B-LF
factor NOUN I-LF
of ADP I-LF
activated VERB I-LF
T PROPN I-LF
- PUNCT I-LF
cells NOUN I-LF
3 NUM I-LF
( PUNCT O
NFATC3 PROPN B-AC
) PUNCT O
was AUX O
measured VERB O
after ADP O
recombinant ADJ O
sFRP2 NOUN O
exposure NOUN O
. PUNCT O

On ADP O
the DET O
other ADJ O
hand NOUN O
, PUNCT O
proneural ADJ O
genes NOUN O
are AUX O
basic ADJ B-LF
helix NOUN I-LF
- PUNCT I-LF
loop NOUN I-LF
- PUNCT I-LF
helix NOUN I-LF
( PUNCT O
bHLH PROPN B-AC
) PUNCT O
transcription NOUN O
factors NOUN O
that PRON O
promote VERB O
cell NOUN O
cycle NOUN O
exit NOUN O
and CCONJ O
neural ADJ O
commitment NOUN O
[ PUNCT O
8 NUM O
] PUNCT O
. PUNCT O

( PUNCT O
A X O
) PUNCT O
Schematic NOUN O
of ADP O
the DET O
rAAV NOUN B-AC
expression NOUN O
cassette NOUN O
with ADP O
internal ADJ B-LF
tandem NOUN I-LF
repeats NOUN I-LF
( PUNCT O
ITR PROPN B-AC
) PUNCT O
, PUNCT O
the DET O
mGluR6 NOUN B-LF
enhancer NOUN I-LF
element NOUN I-LF
( PUNCT O
GRM6 PROPN B-AC
) PUNCT O
, PUNCT O
the DET O
sv40 NOUN B-LF
eukaryotic ADJ I-LF
promoter NOUN I-LF
sequence NOUN I-LF
( PUNCT O
psv40 NOUN B-AC
) PUNCT O
, PUNCT O
an DET O
internal ADJ B-LF
ribosomal ADJ I-LF
entry NOUN I-LF
site NOUN I-LF
( PUNCT O
IRES PROPN B-AC
) PUNCT O
, PUNCT O
woodchuck NOUN B-LF
posttranscriptional ADJ I-LF
regulatory ADJ I-LF
element NOUN I-LF
( PUNCT O
WPRE PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
bovine ADJ B-LF
growth NOUN I-LF
hormone NOUN I-LF
polyadenylation NOUN I-LF
sequence NOUN I-LF
( PUNCT O
BGHpA PROPN B-AC
) PUNCT O
. PUNCT O
( PUNCT O
B X O
) PUNCT O
Retinal ADJ O
whole ADJ O
mount NOUN O
transduced VERB O
by ADP O
intravitreal NOUN O
injection NOUN O
and CCONJ O
stained VERB O
with ADP O
an DET O
antibody NOUN O
against ADP O
TurboFP635 PROPN O
. PUNCT O

HF PROPN B-AC
health NOUN B-LF
facility NOUN I-LF
“ PUNCT O
-“unknown PUNCT O
third ADJ O
quartile NOUN O
. PUNCT O

The DET O
authors NOUN O
of ADP O
the DET O
current ADJ O
study NOUN O
investigated VERB O
and CCONJ O
compared VERB O
the DET O
effects NOUN O
of ADP O
three NUM O
general ADJ O
anesthetics NOUN O
, PUNCT O
isoflurane NOUN B-LF
( PUNCT O
Iso PROPN B-AC
) PUNCT O
, PUNCT O
medetomidine NOUN B-LF
/ SYM I-LF
midazolam NOUN I-LF
/ SYM I-LF
fentanyl NOUN I-LF
( PUNCT O
MMF PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
ketamine NOUN B-LF
/ SYM I-LF
xylazine NOUN I-LF
( PUNCT O
Keta NOUN B-AC
/ SYM B-AC
Xyl NOUN B-AC
) PUNCT O
, PUNCT O
on ADP O
neuronal ADJ O
activity NOUN O
of ADP O
the DET O
mouse NOUN O
hippocampus NOUN O
and CCONJ O
memory NOUN O
consolidation NOUN O
at ADP O
the DET O
behavioral ADJ O
level NOUN O
. PUNCT O

Online ADJ O
fNIRS PROPN B-AC
classification NOUN O
of ADP O
personal ADJ O
questions NOUN O
with ADP O
known VERB O
answers NOUN O
and CCONJ O
open ADJ O
questions NOUN O
using VERB O
linear ADJ O
support NOUN B-LF
vector NOUN I-LF
machine NOUN I-LF
( PUNCT O
SVM PROPN B-AC
) PUNCT O
resulted VERB O
in ADP O
an DET O
above ADP O
- PUNCT O
chance NOUN O
- PUNCT O
level NOUN O
correct ADJ O
response NOUN O
rate NOUN O
over ADP O
70 NUM O
% PUNCT O
. PUNCT O

Thoracic ADJ B-LF
ossification NOUN I-LF
of ADP I-LF
the DET I-LF
ligamentum NOUN I-LF
flavum NOUN I-LF
( PUNCT O
TOLF PROPN B-AC
) PUNCT O
is AUX O
characterized VERB O
by ADP O
ectopic ADJ O
bone NOUN O
formation NOUN O
in ADP O
the DET O
ligamentum NOUN O
flavum NOUN O
and CCONJ O
is AUX O
considered VERB O
to PART O
be AUX O
a DET O
leading VERB O
cause NOUN O
of ADP O
thoracic ADJ O
spinal ADJ O
canal NOUN O
stenosis NOUN O
and CCONJ O
myelopathy NOUN O
. PUNCT O

Insight NOUN O
in ADP O
hospitalizations NOUN O
in ADP O
long ADJ O
- PUNCT O
term NOUN O
childhood NOUN B-LF
cancer NOUN I-LF
survivors NOUN I-LF
( PUNCT O
CCS PROPN B-AC
) PUNCT O
is AUX O
useful ADJ O
to PART O
understand VERB O
the DET O
impact NOUN O
of ADP O
long ADJ O
- PUNCT O
term NOUN O
morbidity NOUN O
. PUNCT O

HR NOUN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
. PUNCT O

PRISMA PROPN B-AC
, PUNCT O
Preferred ADJ B-LF
Reporting NOUN I-LF
Items NOUN I-LF
for ADP I-LF
Systematic ADJ I-LF
Reviews NOUN I-LF
and CCONJ I-LF
Meta NOUN I-LF
- NOUN I-LF
Analysis NOUN I-LF
. PUNCT O

Abbreviation NOUN O
: PUNCT O
ARR PROPN B-AC
, PUNCT O
annual ADJ B-LF
rate NOUN I-LF
of ADP I-LF
reduction NOUN I-LF
; PUNCT O
LLT PROPN B-AC
, PUNCT O
Li PROPN B-LF
– PUNCT I-LF
Lee PROPN I-LF
– PUNCT I-LF
Tuljapurkar PROPN I-LF
; PUNCT O
UN PROPN B-AC
IGME PROPN B-AC
, PUNCT O
United PROPN B-LF
Nations PROPN I-LF
Inter PROPN I-LF
- PROPN I-LF
agency PROPN I-LF
Group PROPN I-LF
for ADP I-LF
Child PROPN I-LF
Mortality PROPN I-LF
Estimation PROPN I-LF
. PUNCT O

Severe ADJ O
alpha-1 NUM B-LF
- PUNCT I-LF
antitrypsin NOUN I-LF
deficiency NOUN I-LF
( PUNCT O
AATD PROPN B-AC
, PUNCT O
MIM PROPN O
# NOUN O
613490 NUM O
) PUNCT O
affects VERB O
approximately ADV O
1 NUM O
in ADP O
2000 NUM O
of ADP O
the DET O
Northern ADJ O
European ADJ O
population NOUN O
. PUNCT O

TTP NOUN B-AC
= PUNCT O
time NOUN B-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
peak NOUN I-LF
. PUNCT O

Computed ADJ B-LF
tomography NOUN I-LF
( PUNCT O
CT NOUN B-AC
) PUNCT O
scan NOUN O
is AUX O
widely ADV O
used VERB O
in ADP O
clinics NOUN O
for ADP O
AF PROPN B-AC
patients NOUN O
especially ADV O
when SCONJ O
undergoing VERB O
radiofrequency NOUN O
catheter NOUN O
ablation NOUN O
. PUNCT O

Clinical ADJ B-LF
medication NOUN I-LF
reviews NOUN I-LF
( PUNCT O
CMRs NOUN B-AC
) PUNCT O
are AUX O
increasingly ADV O
performed VERB O
in ADP O
older ADJ O
persons NOUN O
with ADP O
multimorbidity NOUN O
and CCONJ O
polypharmacy NOUN O
to PART O
reduce VERB O
drug NOUN B-LF
- PUNCT I-LF
related VERB I-LF
problems NOUN I-LF
( PUNCT O
DRPs NOUN B-AC
) PUNCT O
. PUNCT O

Cu PROPN B-AC
reduced VERB O
triglyceride NOUN B-LF
( PUNCT O
TG NOUN B-AC
) PUNCT O
storage NOUN O
and CCONJ O
secretion NOUN O
. PUNCT O

Repair NOUN O
of ADP O
DNA NOUN O
breaks NOUN O
by ADP O
single ADJ B-LF
- PUNCT I-LF
strand NOUN I-LF
annealing NOUN I-LF
( PUNCT O
SSA NOUN B-AC
) PUNCT O
is AUX O
a DET O
major ADJ O
mechanism NOUN O
for ADP O
the DET O
maintenance NOUN O
of ADP O
genomic ADJ O
integrity NOUN O
. PUNCT O

Among ADP O
the DET O
947,091 NUM O
patients NOUN O
who PRON O
underwent VERB O
PCIs NOUN B-AC
included VERB O
in ADP O
the DET O
analytic ADJ O
cohort NOUN O
, PUNCT O
the DET O
mean NOUN O
( PUNCT O
standard ADJ B-LF
deviation NOUN I-LF
[ PUNCT O
SD NOUN B-AC
] PUNCT O
) PUNCT O
of ADP O
their PRON O
age NOUN O
was AUX O
64.8 NUM O
( PUNCT O
12.2 NUM O
) PUNCT O
years NOUN O
, PUNCT O
and CCONJ O
636,078 NUM O
( PUNCT O
32.8 NUM O
% NOUN O
) PUNCT O
were AUX O
women NOUN O
( PUNCT O
S4 PROPN O
Table PROPN O
) PUNCT O
. PUNCT O

Many ADJ O
countries NOUN O
in ADP O
sub ADJ O
- PUNCT O
Saharan PROPN O
Africa PROPN O
use VERB O
sulfadoxine NOUN B-LF
- PUNCT I-LF
pyrimethamine NOUN I-LF
( PUNCT O
SP PROPN B-AC
) PUNCT O
for ADP O
the DET O
treatment NOUN O
of ADP O
clinical ADJ O
malaria NOUN O
in ADP O
pregnancy NOUN O
or CCONJ O
have AUX O
introduced VERB O
intermittent ADJ B-LF
preventive ADJ I-LF
treatment NOUN I-LF
in ADP I-LF
pregnancy NOUN I-LF
( PUNCT O
IPTp NOUN B-AC
) PUNCT O
with ADP O
SP PROPN B-AC
as ADP O
national ADJ O
policy NOUN O
[ PUNCT O
5 NUM O
] PUNCT O
. PUNCT O

Source NOUN O
data NOUN O
for ADP O
A PROPN O
- PUNCT O
C PROPN O
and CCONJ O
E PROPN O
- PUNCT O
H PROPN O
can AUX O
be AUX O
found VERB O
in ADP O
the DET O
supplemental ADJ O
data NOUN O
file NOUN O
( PUNCT O
S1 PROPN O
Data PROPN O
) PUNCT O
. PUNCT O
2C PROPN B-AC
, PUNCT O
2 NUM B-LF
- PUNCT I-LF
cell NOUN I-LF
; PUNCT O
Dppa2 PROPN O
, PUNCT O
developmental ADJ O
pluripotency NOUN O
associated VERB O
2 NUM O
; PUNCT O
Dux PROPN B-AC
, PUNCT O
double ADJ B-LF
homeobox NOUN I-LF
; PUNCT O
ESC PROPN B-AC
, PUNCT O
embryonic ADJ B-LF
stem NOUN I-LF
cell NOUN I-LF
; PUNCT O
IF PROPN B-AC
, PUNCT O
immunofluorescence NOUN B-LF
; PUNCT O
MERVL PROPN B-AC
, PUNCT O
murine NOUN O
endogenous ADJ O
retrovirus NOUN O
- PUNCT O
L NOUN O
; PUNCT O
NC PROPN O
, PUNCT O
negative ADJ O
control NOUN O
; PUNCT O
Pias4 PROPN O
, PUNCT O
protein NOUN O
inhibitor NOUN O
of ADP O
activated VERB O
STAT PROPN O
4 NUM O
; PUNCT O
PLA PROPN B-AC
, PUNCT O
proximity NOUN B-LF
ligation NOUN I-LF
assay NOUN I-LF
; PUNCT O
siRNA PROPN B-AC
, PUNCT O
small ADJ B-LF
interfering VERB I-LF
RNA NOUN I-LF
; PUNCT O
Sumo2 PROPN O
, PUNCT O
small ADJ O
ubiquitin NOUN O
- PUNCT O
like ADJ O
modifier NOUN O
2 NUM O
; PUNCT O
tdTomato PROPN B-AC
, PUNCT O
tandem ADJ B-LF
dimeric ADJ I-LF
Tomato PROPN I-LF
. PUNCT O

Abbreviations NOUN O
: PUNCT O
PCR PROPN B-AC
, PUNCT O
Polymerase PROPN B-LF
Chain PROPN I-LF
Reaction PROPN I-LF
; PUNCT O
IQR PROPN O
, PUNCT O
Inter PROPN O
Quartile PROPN O
Range PROPN O
. PUNCT O

The DET O
young ADJ O
root NOUN O
tissue NOUN O
of ADP O
rice NOUN O
plant NOUN O
( PUNCT O
Oryza NOUN O
sativa NOUN O
‘ PUNCT O
IR36 PROPN O
’ PUNCT O
) PUNCT O
was AUX O
treated VERB O
similarly ADV O
and CCONJ O
used VERB O
as ADP O
the DET O
reference NOUN O
standard NOUN O
( PUNCT O
1.01pg/2C NOUN O
) PUNCT O
[ X O
21 NUM O
] X O
The DET O
nuclei NOUN O
of ADP O
both DET O
the DET O
plants NOUN O
were AUX O
then ADV O
treated VERB O
with ADP O
50 NUM O
μg NOUN O
ml-1 NUM O
RNase NOUN O
A NOUN O
and CCONJ O
simultaneously ADV O
stained VERB O
with ADP O
50 NUM O
μg NOUN O
ml-1 NUM O
of ADP O
propidium NOUN B-LF
iodide NOUN I-LF
( PUNCT O
PI PROPN B-AC
) PUNCT O
prior ADV O
to ADP O
incubation NOUN O
on ADP O
ice NOUN O
for ADP O
10 NUM O
min NOUN O
. PUNCT O

By ADP O
comparing VERB O
lipid NOUN O
profiles NOUN O
of ADP O
phosphate NOUN O
- PUNCT O
starved VERB O
WT PROPN O
C. PROPN O
neoformans NOUN O
, PUNCT O
PHO4 NOUN O
( PUNCT O
pho4Δ NOUN O
) PUNCT O
and CCONJ O
BTA1 PROPN O
( PUNCT O
bta1Δ NOUN O
) PUNCT O
deletion NOUN O
mutants NOUN O
using VERB O
thin ADJ O
layer NOUN O
chromatography NOUN O
and CCONJ O
liquid NOUN O
chromatography NOUN O
mass NOUN O
spectrometry NOUN O
, PUNCT O
we PRON O
showed VERB O
that SCONJ O
phosphatidylcholine NOUN B-LF
( PUNCT O
PC NOUN B-AC
) PUNCT O
is AUX O
substituted VERB O
by ADP O
the DET O
phosphorus NOUN O
- PUNCT O
free ADJ O
betaine NOUN O
lipids NOUN O
diacylglyceryl NOUN B-LF
- PUNCT I-LF
N NOUN I-LF
, PUNCT I-LF
N NOUN I-LF
, PUNCT I-LF
N NOUN I-LF
- PUNCT I-LF
trimethylhomoserine NOUN I-LF
( PUNCT O
DGTS PROPN B-AC
) PUNCT O
and CCONJ O
diacylgyceryl NOUN B-LF
hydroxymethyl NOUN I-LF
- PUNCT I-LF
N NOUN I-LF
, PUNCT I-LF
N NOUN I-LF
, PUNCT I-LF
N NOUN I-LF
- PUNCT I-LF
trimethyl NOUN I-LF
- PUNCT I-LF
beta NOUN I-LF
- PUNCT I-LF
alanine NOUN I-LF
( PUNCT O
DGTA PROPN B-AC
) PUNCT O
in ADP O
a DET O
Pho4- NOUN O
and CCONJ O
Bta1 NOUN O
- PUNCT O
dependent ADJ O
manner NOUN O
, PUNCT O
and CCONJ O
that SCONJ O
BTA1 PROPN O
encodes VERB O
a DET O
functional ADJ O
DGTS PROPN B-AC
synthase NOUN O
. PUNCT O

The DET O
prediction NOUN B-LF
report NOUN I-LF
status NOUN O
is AUX O
stored VERB O
in ADP O
RSU PROPN O
- PUNCT O
PR PROPN B-AC
register NOUN O
as SCONJ O
shown VERB O
in ADP O
Table NOUN O
5 NUM O
. PUNCT O

In ADP O
intestinal ADJ O
tissue NOUN O
, PUNCT O
IL-22 NOUN B-AC
is AUX O
mainly ADV O
produced VERB O
by ADP O
ILC3 PROPN O
cells NOUN O
[ PUNCT O
59 NUM O
] PUNCT O
, PUNCT O
CD4 PROPN O
+ NOUN O
T PROPN O
cells NOUN O
[ PUNCT O
77 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
, PUNCT O
to ADP O
a DET O
lesser ADJ O
extent NOUN O
, PUNCT O
CD8 PROPN O
+ NOUN O
T PROPN O
cells NOUN O
, PUNCT O
T PROPN O
- PUNCT O
cell NOUN O
receptor NOUN O
( PUNCT O
TCR)γδ NOUN O
T PROPN O
cells NOUN O
, PUNCT O
neutrophils NOUN O
, PUNCT O
and CCONJ O
natural ADJ B-LF
killer NOUN I-LF
( PUNCT O
NK PROPN B-AC
) PUNCT O
cells NOUN O
[ PUNCT O
78,79 NUM O
] PUNCT O
. PUNCT O

HR NOUN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT O
CI PROPN O
, PUNCT O
confidence NOUN O
interval NOUN O
. PUNCT O

No DET O
personal ADJ O
medical ADJ O
history NOUN O
of ADP O
myocardial ADJ B-LF
infarction NOUN I-LF
( PUNCT O
MI NOUN B-AC
) PUNCT O
, PUNCT O
coronary ADJ B-LF
artery NOUN I-LF
disease NOUN I-LF
( PUNCT O
CAD PROPN B-AC
) PUNCT O
, PUNCT O
peripheral ADJ B-LF
arterial ADJ I-LF
disease NOUN I-LF
( PUNCT O
PAD PROPN B-AC
) PUNCT O
, PUNCT O
stroke NOUN O
, PUNCT O
cancer NOUN O
, PUNCT O
autoimmune ADJ O
/ SYM O
genetic ADJ O
disease NOUN O
, PUNCT O
endocrine ADJ O
disease NOUN O
, PUNCT O
diabetes NOUN O
mellitus NOUN O
, PUNCT O
psychiatric ADJ O
illness NOUN O
, PUNCT O
asthma NOUN O
, PUNCT O
or CCONJ O
chronic ADJ O
lung NOUN O
disease NOUN O
and CCONJ O
chronic ADJ O
infective ADJ O
disease NOUN O
. PUNCT O

Although SCONJ O
previous ADJ O
studies NOUN O
conducted VERB O
in ADP O
sub ADJ B-LF
- PUNCT I-LF
Saharan PROPN I-LF
Africa PROPN I-LF
( PUNCT O
SSA PROPN B-AC
) PUNCT O
have AUX O
made VERB O
mention NOUN O
of ADP O
similar ADJ O
barriers NOUN O
to ADP O
integrating VERB O
NCD PROPN B-AC
management NOUN O
, PUNCT O
majority NOUN O
of ADP O
the DET O
studies NOUN O
focused VERB O
on ADP O
other ADJ O
chronic ADJ O
diseases NOUN O
( PUNCT O
i.e. X O
cervical ADJ O
cancer NOUN O
, PUNCT O
mental ADJ O
health NOUN O
, PUNCT O
diabetes NOUN O
) PUNCT O
but CCONJ O
not PART O
hypertension NOUN O
, PUNCT O
which PRON O
is AUX O
characterized VERB O
as ADP O
a DET O
silent ADJ O
killer NOUN O
and CCONJ O
is AUX O
currently ADV O
the DET O
leading VERB O
risk NOUN O
factor NOUN O
for ADP O
CVD.[17–21 NUM B-AC
] PUNCT O
The DET O
identification NOUN O
of ADP O
barriers NOUN O
or CCONJ O
enablers NOUN O
by ADP O
themselves PRON O
are AUX O
also ADV O
not PART O
a DET O
new ADJ O
undertaking NOUN O
[ PUNCT O
22 NUM O
] PUNCT O
; PUNCT O
however ADV O
, PUNCT O
our PRON O
approach NOUN O
to ADP O
the DET O
assessment NOUN O
of ADP O
these DET O
barriers NOUN O
across ADP O
multiple ADJ O
clinical ADJ O
sites NOUN O
is AUX O
unique ADJ O
and CCONJ O
may AUX O
potentially ADV O
inform VERB O
the DET O
development NOUN O
of ADP O
interventions NOUN O
targeting VERB O
the DET O
capabilities NOUN O
, PUNCT O
opportunities NOUN O
, PUNCT O
and CCONJ O
motivations NOUN O
for ADP O
successful ADJ O
service NOUN O
delivery NOUN O
of ADP O
evidence NOUN O
- PUNCT O
based VERB O
hypertension NOUN O
interventions NOUN O
within ADP O
HIV PROPN B-AC
clinics NOUN O
. PUNCT O

Performance NOUN O
in ADP O
distinguishing VERB O
early ADJ O
stage NOUN O
PDAC PROPN B-AC
( PUNCT O
stage NOUN O
I NOUN O
– SYM O
II NOUN O
) PUNCT O
( PUNCT O
n NOUN O
= SYM O
80 NUM O
) PUNCT O
from ADP O
control NOUN O
samples NOUN O
( PUNCT O
n NOUN O
= SYM O
92 NUM O
) PUNCT O
( PUNCT O
A NOUN O
and CCONJ O
C NOUN O
) PUNCT O
and CCONJ O
benign ADJ O
samples NOUN O
( PUNCT O
n NOUN O
= SYM O
108 NUM O
) PUNCT O
( PUNCT O
B NOUN O
and CCONJ O
D NOUN O
) PUNCT O
. PUNCT O
ROC PROPN B-AC
curves NOUN O
of ADP O
CA19 PROPN O
- PUNCT O
9 NUM O
and CCONJ O
biomarker NOUN O
panel NOUN O
alone ADV O
and CCONJ O
in ADP O
combination NOUN O
( PUNCT O
A NOUN O
and CCONJ O
B NOUN O
) PUNCT O
; PUNCT O
summary NOUN O
of ADP O
the DET O
performances NOUN O
( PUNCT O
C NOUN O
and CCONJ O
D NOUN O
) PUNCT O
. PUNCT O
AUC PROPN B-AC
, PUNCT O
area NOUN B-LF
under ADP I-LF
the DET I-LF
receiver NOUN I-LF
operating NOUN I-LF
characteristic NOUN I-LF
curve NOUN I-LF
; PUNCT O
CI PROPN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
PDAC PROPN B-AC
, PUNCT O
pancreatic ADJ B-LF
ductal ADJ I-LF
adenocarcinoma NOUN I-LF
; PUNCT O
ROC PROPN B-AC
, PUNCT O
receiver NOUN B-LF
operating NOUN I-LF
characteristic NOUN I-LF
; PUNCT O
SN PROPN B-AC
, PUNCT O
sensitivity NOUN B-LF
; PUNCT O
SP PROPN B-AC
, PUNCT O
specificity NOUN B-LF
. PUNCT O

Total ADJ O
RNA PROPN O
quantity NOUN O
was AUX O
determined VERB O
by ADP O
the DET O
absorbance NOUN O
at ADP O
260 NUM O
nm NOUN O
using VERB O
a DET O
nanoVue NOUN O
spectrophotometer NOUN O
( PUNCT O
GE PROPN O
Healthcare PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
. PUNCT O
RNA PROPN O
Integrity PROPN O
was AUX O
ensured VERB O
by ADP O
obtaining VERB O
an DET O
RNA PROPN B-LF
Integrity PROPN I-LF
Number PROPN I-LF
— PUNCT O
RIN PROPN B-AC
> SYM O
8 NUM O
with ADP O
Agilent PROPN O
2100 NUM O
Bioanalyzer PROPN O
( PUNCT O
Agilent PROPN O
Technologies PROPN O
, PUNCT O
Germany PROPN O
) PUNCT O
[ PUNCT O
30 NUM O
] PUNCT O
. PUNCT O

Analyses NOUN O
of ADP O
human ADJ O
peripheral ADJ B-LF
blood NOUN I-LF
mononuclear ADJ I-LF
cells NOUN I-LF
( PUNCT O
PBMCs PROPN B-AC
) PUNCT O
can AUX O
be AUX O
done VERB O
on ADP O
freshly ADV O
collected VERB O
blood NOUN O
samples NOUN O
or CCONJ O
on ADP O
cryopreserved ADJ O
samples NOUN O
. PUNCT O

As SCONJ O
expected VERB O
from ADP O
randomization NOUN O
, PUNCT O
baseline NOUN O
characteristics NOUN O
were AUX O
similar ADJ O
between ADP O
arms NOUN O
, PUNCT O
with ADP O
the DET O
exception NOUN O
of ADP O
enrollment NOUN O
head NOUN O
circumference NOUN O
z NOUN O
- NOUN O
scores NOUN O
, PUNCT O
which PRON O
were AUX O
higher ADJ O
in ADP O
the DET O
nicotinamide NOUN O
group NOUN O
compared VERB O
to ADP O
placebo NOUN O
( PUNCT O
0.03 NUM O
versus ADP O
−0.09 NUM O
, PUNCT O
difference NOUN O
0.12 NUM O
, PUNCT O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
[ X O
CI NOUN B-AC
] X O
−0.249 NUM O
, PUNCT O
−0.01 NUM O
) PUNCT O
( PUNCT O
Table PROPN O
1 NUM O
) PUNCT O
. PUNCT O

ART PROPN B-AC
, PUNCT O
antiretroviral ADJ B-LF
therapy NOUN I-LF
; PUNCT O
RR PROPN B-AC
, PUNCT O
risk NOUN B-LF
ratio NOUN I-LF
. PUNCT O

Underdetection NOUN O
may AUX O
also ADV O
proceed VERB O
from ADP O
the DET O
imperfect ADJ O
characteristics NOUN O
of ADP O
RT PROPN B-AC
- PUNCT B-AC
PCR PROPN B-AC
( PUNCT O
reverse ADJ B-LF
transcription NOUN I-LF
- PUNCT I-LF
polymerase NOUN I-LF
chain NOUN I-LF
reaction NOUN I-LF
) PUNCT O
tests NOUN O
used VERB O
to PART O
identify VERB O
infected ADJ O
cases NOUN O
. PUNCT O

A DET O
Community NOUN B-LF
- PUNCT I-LF
Led VERB I-LF
Total PROPN I-LF
Sanitation PROPN I-LF
and CCONJ I-LF
Hygiene PROPN I-LF
program NOUN I-LF
( PUNCT O
CLTSH PROPN B-AC
) PUNCT O
has AUX O
been AUX O
put VERB O
into ADP O
practice NOUN O
in ADP O
all DET O
rural ADJ O
Kebeles PROPN O
since SCONJ O
2013 NUM O
. PUNCT O

The DET O
progress NOUN O
of ADP O
the DET O
reaction NOUN O
was AUX O
followed VERB O
by ADP O
high ADJ B-LF
- PUNCT I-LF
performance NOUN I-LF
liquid NOUN I-LF
chromatography NOUN I-LF
( PUNCT O
HPLC PROPN B-AC
) PUNCT O
analyses NOUN O
. PUNCT O

CaM PROPN B-AC
, PUNCT O
calmodulin NOUN B-LF
; PUNCT O
SR NOUN B-AC
- PUNCT B-AC
CD PROPN B-AC
, PUNCT O
synchrotron NOUN B-LF
radiation NOUN I-LF
circular ADJ I-LF
dichroism NOUN I-LF
. PUNCT O

Error- NOUN O
and CCONJ O
feedback NOUN B-LF
- PUNCT I-LF
related VERB I-LF
potentials NOUN I-LF
( PUNCT O
error NOUN B-LF
- PUNCT I-LF
related VERB I-LF
negativity NOUN I-LF
[ X O
ERN PROPN B-AC
] X O
and CCONJ O
feedback NOUN O
potentials NOUN O
[ X O
FRPs PROPN B-AC
] X O
) PUNCT O
recorded VERB O
over ADP O
the DET O
medial ADJ O
part NOUN O
of ADP O
the DET O
frontal ADJ O
lobe NOUN O
in ADP O
electroencephalography NOUN B-LF
( PUNCT O
EEG PROPN B-AC
) PUNCT O
[ X O
5–7 NUM O
] X O
, PUNCT O
electrocorticography NOUN B-LF
( PUNCT O
ECoG PROPN B-AC
) PUNCT O
[ X O
8 NUM O
] X O
, PUNCT O
and CCONJ O
local ADJ B-LF
field NOUN I-LF
potential NOUN I-LF
( PUNCT O
LFP PROPN B-AC
) PUNCT O
[ X O
9 NUM O
] X O
differentiate VERB O
outcome NOUN O
valences NOUN O
. PUNCT O

To PART O
evaluate VERB O
plasma NOUN O
membrane NOUN O
integrity NOUN O
, PUNCT O
cells NOUN O
were AUX O
grown VERB O
in ADP O
a DET O
48 NUM O
- PUNCT O
well NOUN O
microplate NOUN O
, PUNCT O
and CCONJ O
a DET O
commercial ADJ O
kit NOUN O
by ADP O
the DET O
decrease NOUN O
of ADP O
OD NOUN O
at ADP O
340 NUM O
nm NOUN O
( PUNCT O
Wiener PROPN O
lab NOUN O
) PUNCT O
was AUX O
used VERB O
to PART O
measure VERB O
the DET O
release NOUN O
of ADP O
the DET O
cytoplasmic ADJ O
enzyme NOUN O
lactate NOUN B-LF
dehydrogenase NOUN I-LF
( PUNCT O
LDH PROPN B-AC
) PUNCT O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
LLoQ PROPN O
, PUNCT O
lower ADJ O
limit NOUN O
of ADP O
quantification NOUN O
; PUNCT O
PP PROPN B-AC
, PUNCT O
per ADP B-LF
- PUNCT I-LF
protocol NOUN I-LF
; PUNCT O
P3 PROPN B-AC
, PUNCT O
placebo NOUN B-LF
group NOUN I-LF
3 NUM I-LF
; PUNCT O
q NOUN O
, PUNCT O
quodque NOUN O
; PUNCT O
SC PROPN B-AC
, PUNCT O
subcutaneous ADJ B-LF
; PUNCT O
T1 PROPN B-AC
, PUNCT O
treatment NOUN B-LF
group NOUN I-LF
1 NUM I-LF
; PUNCT O
T2 PROPN B-AC
, PUNCT O
treatment NOUN B-LF
group NOUN I-LF
2 NUM I-LF
; PUNCT O
T3 PROPN B-AC
, PUNCT O
treatment NOUN B-LF
group NOUN I-LF
3 NUM I-LF
; PUNCT O
T4 PROPN B-AC
, PUNCT O
treatment NOUN B-LF
group NOUN I-LF
4 NUM I-LF
; PUNCT O
T5 PROPN B-AC
, PUNCT O
treatment NOUN B-LF
group NOUN I-LF
5 NUM I-LF
. PUNCT O

CDS PROPN B-AC
, PUNCT O
coding VERB B-LF
DNA NOUN I-LF
sequence NOUN I-LF
; PUNCT O
NGS PROPN O
, PUNCT O
next ADJ O
- PUNCT O
generation NOUN O
sequencing NOUN O
; PUNCT O
RPF PROPN B-AC
, PUNCT O
ribosome NOUN B-LF
- PUNCT I-LF
protected VERB I-LF
mRNA NOUN I-LF
fragment NOUN I-LF
; PUNCT O
RPKM PROPN B-AC
, PUNCT O
reads NOUN B-LF
per ADP I-LF
kilobase NOUN I-LF
of ADP I-LF
transcript NOUN I-LF
per ADP I-LF
million NUM I-LF
mapped VERB I-LF
reads NOUN I-LF
; PUNCT O
uORF PROPN B-AC
, PUNCT O
upstream ADJ B-LF
open ADJ I-LF
reading NOUN I-LF
frame NOUN I-LF
; PUNCT O
UTR PROPN B-AC
, PUNCT O
untranslated ADJ B-LF
region NOUN I-LF
. PUNCT O

SMA PROPN B-LF
type NOUN I-LF
III NUM I-LF
– PUNCT O
In ADP O
our PRON O
cohort NOUN O
of ADP O
SMA3 PROPN B-AC
, PUNCT O
FVC PROPN B-AC
and CCONJ O
FEV1 PROPN B-AC
were AUX O
within ADP O
predicted VERB O
values NOUN O
, PUNCT O
with ADP O
slightly ADV O
lower ADJ O
values NOUN O
of ADP O
PCF PROPN B-AC
, PUNCT O
and CCONJ O
normal ADJ O
ventilatory ADJ O
and CCONJ O
thoraco ADJ O
- PUNCT O
abdominal ADJ O
patterns NOUN O
. PUNCT O

We PRON O
recently ADV O
identified VERB O
the DET O
cystein NOUN B-LF
- ADJ I-LF
rich ADJ I-LF
inter ADJ I-LF
- ADJ I-LF
domain ADJ I-LF
region NOUN I-LF
1α NUM I-LF
( PUNCT O
CIDR1α NOUN B-AC
) PUNCT O
of ADP O
the DET O
Plasmodium PROPN O
falciparum NOUN O
membrane NOUN O
protein NOUN O
1 NUM O
as ADP O
a DET O
polyclonal ADJ O
B NOUN O
cell NOUN O
activator NOUN O
that PRON O
preferentially ADV O
activates VERB O
the DET O
memory NOUN O
compartment NOUN O
, PUNCT O
where SCONJ O
EBV PROPN B-AC
is AUX O
known VERB O
to PART O
persist VERB O
. PUNCT O

Intra ADJ O
- PUNCT O
class NOUN O
correlation NOUN O
coefficients NOUN O
( PUNCT O
ICC NOUN B-AC
) PUNCT O
for ADP O
surface NOUN O
( PUNCT O
in ADP O
mm2 NUM O
) PUNCT O
and CCONJ O
depth NOUN O
( PUNCT O
in ADP O
mm NOUN O
) PUNCT O
between ADP O
flat ADJ O
panel NOUN O
computed VERB O
tomography NOUN O
arthrography NOUN O
( PUNCT O
FPCT NOUN B-AC
- PUNCT B-AC
A NOUN B-AC
) PUNCT O
, PUNCT O
magnetic ADJ B-LF
resonance NOUN I-LF
arthrography NOUN I-LF
( PUNCT O
MR NOUN B-AC
- PUNCT B-AC
A NOUN B-AC
) PUNCT O
and CCONJ O
cast VERB O
specimens NOUN O
. PUNCT O

Importantly ADV O
, PUNCT O
the DET O
simulations NOUN O
only ADV O
consider VERB O
base NOUN O
substitutions NOUN O
, PUNCT O
not PART O
insertions NOUN B-LF
or CCONJ I-LF
deletions NOUN I-LF
( PUNCT O
indels NOUN B-AC
) PUNCT O
. PUNCT O

Changes NOUN O
in ADP O
blood NOUN B-LF
oxygen NOUN I-LF
level NOUN I-LF
– PUNCT I-LF
dependent ADJ I-LF
( PUNCT O
BOLD PROPN B-AC
) PUNCT O
responses NOUN O
elicited VERB O
by ADP O
congruent ADJ O
audiovisual ADJ O
stimuli NOUN O
( PUNCT O
AV PROPN O
) PUNCT O
have AUX O
been AUX O
compared VERB O
to ADP O
auditory ADJ O
- PUNCT O
only ADV O
( PUNCT O
AO NOUN O
) PUNCT O
, PUNCT O
visual ADJ O
- PUNCT O
only ADV O
( PUNCT O
VO NOUN O
) PUNCT O
, PUNCT O
their PRON O
sum NOUN O
( PUNCT O
AO NOUN O
+ SYM O
VO NOUN O
) PUNCT O
, PUNCT O
or CCONJ O
their PRON O
conjunction NOUN O
( PUNCT O
AO NOUN O
∩ SYM O
VO NOUN O
) PUNCT O
. PUNCT O
Greater ADJ O
activation NOUN O
for ADP O
the DET O
congruent ADJ O
audiovisual ADJ O
condition NOUN O
( PUNCT O
AV PROPN O
) PUNCT O
compared VERB O
to ADP O
others NOUN O
has AUX O
been AUX O
interpreted VERB O
as ADP O
a DET O
signature NOUN O
of ADP O
audiovisual ADJ O
speech NOUN O
integration NOUN O
. PUNCT O

To PART O
test VERB O
the DET O
hypothesis NOUN O
that SCONJ O
IPs NOUN B-AC
and CCONJ O
other ADJ O
metabolites NOUN O
modulate VERB O
the DET O
translocation NOUN O
of ADP O
dNTPs NOUN B-AC
through ADP O
CA PROPN O
oligomers NOUN O
, PUNCT O
we PRON O
have AUX O
employed VERB O
a DET O
multipronged ADJ O
approach NOUN O
combining VERB O
all DET O
- PUNCT O
atom NOUN O
molecular ADJ B-LF
dynamics NOUN I-LF
( PUNCT O
MD PROPN B-AC
) PUNCT O
simulations NOUN O
[ PUNCT O
19 NUM O
] PUNCT O
, PUNCT O
atomic ADJ B-LF
force NOUN I-LF
microscopy NOUN I-LF
( PUNCT O
AFM PROPN B-AC
) PUNCT O
, PUNCT O
transmission NOUN B-LF
electron NOUN I-LF
microscopy NOUN I-LF
( PUNCT O
TEM PROPN B-AC
) PUNCT O
, PUNCT O
confocal ADJ O
microscopy NOUN O
, PUNCT O
and CCONJ O
virus NOUN O
infectivity NOUN O
assays NOUN O
. PUNCT O

HCP PROPN B-AC
, PUNCT O
healthcare NOUN B-LF
professional NOUN I-LF
. PUNCT O

AUC PROPN B-AC
, PUNCT O
area NOUN O
under ADP O
the DET O
receiver NOUN O
operating VERB O
characteristic ADJ O
curve NOUN O
; PUNCT O
TG NOUN B-AC
, PUNCT O
trigeminal ADJ B-LF
ganglion NOUN I-LF
. PUNCT O

DRG PROPN B-AC
, PUNCT O
dorsal ADJ B-LF
root NOUN I-LF
ganglia NOUN I-LF
; PUNCT O
S.C. PROPN O
, PUNCT O
spinal ADJ O
cord NOUN O
. PUNCT O

GFP PROPN B-AC
= PUNCT O
the DET B-LF
peel NOUN I-LF
of ADP I-LF
green ADJ I-LF
fruit NOUN I-LF
; PUNCT O
GFS PROPN B-AC
= PUNCT O
the DET B-LF
sarcocarp NOUN I-LF
of ADP I-LF
green ADJ I-LF
fruit NOUN I-LF
; PUNCT O
FP PROPN B-AC
= PUNCT O
the DET B-LF
peel NOUN I-LF
of ADP I-LF
red ADJ I-LF
fruit NOUN I-LF
; PUNCT O
FS PROPN B-AC
= PUNCT O
the DET B-LF
sarcocarp NOUN I-LF
of ADP I-LF
red ADJ I-LF
fruit NOUN I-LF
. PUNCT O

The DET O
obtained VERB O
molecular ADJ O
structure NOUN O
suggests VERB O
that SCONJ O
, PUNCT O
like ADP O
its PRON O
A. PROPN O
thaliana PROPN O
ortholog NOUN O
, PUNCT O
KDM1 PROPN O
represents VERB O
a DET O
tetrameric ADJ O
KV NOUN O
channel NOUN O
with ADP O
a DET O
non ADJ O
- PUNCT O
domain NOUN O
- PUNCT O
swapped VERB O
subunit NOUN O
arrangement NOUN O
of ADP O
its PRON O
voltage NOUN B-LF
- PUNCT I-LF
sensing VERB I-LF
domains NOUN I-LF
( PUNCT O
VSDs NOUN B-AC
; PUNCT O
S1 NOUN O
to ADP O
S4 PROPN O
) PUNCT O
and CCONJ O
a DET O
central ADJ O
pore NOUN B-LF
domain NOUN I-LF
( PUNCT O
PD NOUN B-AC
; PUNCT O
S5 PROPN O
- PUNCT O
P PROPN O
- PUNCT O
S6 PROPN O
) PUNCT O
, PUNCT O
followed VERB O
by ADP O
a DET O
“ PUNCT O
C NOUN O
- PUNCT O
linker NOUN O
” PUNCT O
helix NOUN O
and CCONJ O
a DET O
pseudo ADJ O
cyclic ADJ O
nucleotide NOUN O
- PUNCT O
binding VERB O
domain NOUN O
[ PUNCT O
20 NUM O
] PUNCT O
. PUNCT O

GCL PROPN O
, PUNCT O
ganglion NOUN O
cell NOUN O
layer NOUN O
; PUNCT O
INL PROPN B-AC
, PUNCT O
inner ADJ B-LF
nuclear ADJ I-LF
layer NOUN I-LF
; PUNCT O
ONL PROPN B-AC
, PUNCT O
outer ADJ B-LF
nuclear ADJ I-LF
layer NOUN I-LF
; PUNCT O
ON PROPN O
, PUNCT O
optic ADJ O
nerve NOUN O
; PUNCT O
PZ PROPN O
, PUNCT O
proliferative ADJ O
zone NOUN O
. PUNCT O

There PRON O
were VERB O
no DET O
significant ADJ O
differences NOUN O
in ADP O
outcome NOUN O
between ADP O
the DET O
azithromycin NOUN O
group NOUN O
( PUNCT O
n NOUN O
= SYM O
1,096 NUM O
) PUNCT O
and CCONJ O
the DET O
placebo NOUN O
group NOUN O
( PUNCT O
n NOUN O
= SYM O
1,087 NUM O
) PUNCT O
in ADP O
respect NOUN O
of ADP O
preterm ADJ O
birth NOUN O
( PUNCT O
16.8 NUM O
% NOUN O
versus ADP O
17.4 NUM O
% NOUN O
) PUNCT O
, PUNCT O
odds NOUN B-LF
ratio NOUN I-LF
( PUNCT O
OR PROPN B-AC
) PUNCT O
0.96 NUM O
, PUNCT O
95 NUM O
% NOUN O
confidence NOUN O
interval NOUN O
( PUNCT O
0.76–1.21 NUM O
) PUNCT O
; PUNCT O
mean ADJ O
gestational ADJ O
age NOUN O
at ADP O
delivery NOUN O
( PUNCT O
38.5 NUM O
versus ADP O
38.4 NUM O
weeks NOUN O
) PUNCT O
, PUNCT O
mean ADJ O
difference NOUN O
0.16 NUM O
( PUNCT O
−0.08 NUM O
to PART O
0.40 NUM O
) PUNCT O
; PUNCT O
mean ADJ O
birthweight NOUN O
( PUNCT O
3.03 NUM O
versus ADP O
2.99 NUM O
kg NOUN O
) PUNCT O
, PUNCT O
mean ADJ O
difference NOUN O
0.04 NUM O
( PUNCT O
−0.005 NUM O
to PART O
0.08 NUM O
) PUNCT O
; PUNCT O
perinatal ADJ O
deaths NOUN O
( PUNCT O
4.3 NUM O
% NOUN O
versus ADP O
5.0 NUM O
% NOUN O
) PUNCT O
, PUNCT O
OR PROPN B-AC
0.85 NUM O
( PUNCT O
0.53–1.38 NUM O
) PUNCT O
; PUNCT O
or CCONJ O
maternal ADJ O
malarial ADJ O
parasitaemia NOUN O
( PUNCT O
11.5 NUM O
% NOUN O
versus ADP O
10.1 NUM O
% NOUN O
) PUNCT O
, PUNCT O
OR PROPN B-AC
1.11 NUM O
( PUNCT O
0.84–1.49 NUM O
) PUNCT O
and CCONJ O
anaemia NOUN O
( PUNCT O
44.1 NUM O
% NOUN O
versus ADP O
41.3 NUM O
% NOUN O
) PUNCT O
at ADP O
28–32 NUM O
weeks NOUN O
, PUNCT O
OR PROPN B-AC
1.07 NUM O
( PUNCT O
0.88–1.30 NUM O
) PUNCT O
. PUNCT O

Environmental ADJ B-LF
enrichment NOUN I-LF
significantly ADV O
increased VERB O
spatial ADJ O
coherence NOUN O
of ADP O
pyramidal ADJ O
cells NOUN O
to ADP O
0.256 NUM O
± SYM O
0.029 NUM O
( PUNCT O
p NOUN O
= SYM O
0.001 NUM O
, PUNCT O
Wald PROPN O
Chi NOUN O
- PUNCT O
Square PROPN O
8.637 NUM O
, PUNCT O
Cohen PROPN O
’s PART O
d NOUN O
0.41 NUM O
; PUNCT O
MAM PROPN O
- PUNCT O
E PROPN O
compared VERB O
to ADP O
MAM PROPN O
unenriched ADJ O
) PUNCT O
, PUNCT O
consistent ADJ O
with ADP O
our PRON O
prior ADJ O
findings NOUN O
that SCONJ O
EE PROPN B-AC
significantly ADV O
improves VERB O
spatial ADJ O
learning NOUN O
and CCONJ O
memory NOUN O
. PUNCT O

BMDM PROPN B-AC
, PUNCT O
bone NOUN B-LF
marrow NOUN I-LF
– PUNCT I-LF
derived VERB I-LF
MΦ PROPN I-LF
; PUNCT O
CFU PROPN O
, PUNCT O
colony NOUN O
forming VERB O
unit NOUN O
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
HS PROPN B-AC
, PUNCT O
high ADJ B-LF
salt NOUN I-LF
; PUNCT O
LPS PROPN B-AC
, PUNCT O
lipopolysaccharide NOUN B-LF
; PUNCT O
mLC3 PROPN B-AC
, PUNCT O
microtubule NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
protein NOUN I-LF
1 NUM I-LF
light NOUN I-LF
chain NOUN I-LF
3 NUM I-LF
; PUNCT O
MΦ PROPN B-AC
, PUNCT O
monocyte NOUN B-LF
/ SYM I-LF
macrophage NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
cell NOUN I-LF
; PUNCT O
NFAT5 PROPN B-AC
, PUNCT O
nuclear ADJ B-LF
factor NOUN I-LF
of ADP I-LF
activated VERB I-LF
T PROPN I-LF
cells NOUN I-LF
5 NUM I-LF
; PUNCT O
Nos2 PROPN O
, PUNCT O
nitric NOUN O
oxide NOUN O
synthase NOUN O
2 NUM O
; PUNCT O
NS PROPN B-AC
, PUNCT O
normal ADJ B-LF
salt NOUN I-LF
; PUNCT O
ns PROPN B-AC
, PUNCT O
nonsilencing NOUN B-LF
; PUNCT O
n.s PROPN O
. PUNCT O
, PUNCT O
not PART O
significant ADJ O
; PUNCT O
RFP PROPN B-AC
, PUNCT O
red ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
siRNA PROPN B-AC
, PUNCT O
small ADJ B-LF
interfering VERB I-LF
RNA NOUN I-LF
; PUNCT O
Slc8 PROPN O
, PUNCT O
solute NOUN O
carrier NOUN O
family NOUN O
8 NUM O
. PUNCT O

We PRON O
have AUX O
also ADV O
developed VERB O
matrix NOUN B-LF
- PUNCT I-LF
assisted VERB I-LF
laser NOUN I-LF
desorption NOUN I-LF
/ SYM I-LF
ionisation NOUN I-LF
mass NOUN I-LF
spectrometry NOUN I-LF
( PUNCT O
MALDI PROPN B-AC
- PUNCT B-AC
MS PROPN B-AC
) PUNCT O
assays NOUN O
for ADP O
high ADJ O
- PUNCT O
throughput NOUN O
epigenotyping NOUN O
of ADP O
the DET O
analysed VERB O
regions NOUN O
. PUNCT O

LRR PROPN B-AC
, PUNCT O
leucine NOUN B-LF
- PUNCT I-LF
rich ADJ I-LF
repeat NOUN I-LF
. PUNCT O

The DET O
suspension NOUN B-LF
glycan NOUN I-LF
array NOUN I-LF
( PUNCT O
SGA PROPN B-AC
) PUNCT O
is AUX O
a DET O
multiplex ADJ O
analysis NOUN O
system NOUN O
permitting VERB O
the DET O
simultaneous ADJ O
analysis NOUN O
of ADP O
multiple ADJ O
different ADJ O
biomolecules NOUN O
and CCONJ O
includes VERB O
( PUNCT O
i X O
) PUNCT O
the DET O
production NOUN O
of ADP O
glycopolymers NOUN O
composed VERB O
of ADP O
a DET O
polyacrylamide NOUN O
carrier NOUN O
provided VERB O
with ADP O
end NOUN O
biotin NOUN O
groups NOUN O
and CCONJ O
side NOUN O
- PUNCT O
pendant NOUN O
glycan NOUN O
residues NOUN O
chemically ADV O
synthesized VERB O
or CCONJ O
purchased VERB O
, PUNCT O
( PUNCT O
ii X O
) PUNCT O
the DET O
coupling NOUN O
of ADP O
these DET O
glycopolymers NOUN O
to ADP O
fluorescent ADJ O
microbeads NOUN O
, PUNCT O
( PUNCT O
iii X O
) PUNCT O
the DET O
incubation NOUN O
of ADP O
these DET O
beads NOUN O
with ADP O
serum NOUN O
samples NOUN O
, PUNCT O
and CCONJ O
( PUNCT O
iv X O
) PUNCT O
the DET O
measurement NOUN O
of ADP O
the DET O
AGA PROPN B-AC
hybridized VERB O
to ADP O
the DET O
glycopolymers NOUN O
( PUNCT O
“ PUNCT O
binding VERB O
” PUNCT O
) PUNCT O
using VERB O
fluorescently ADV O
labelled VERB O
reporter NOUN O
molecules NOUN O
( PUNCT O
secondary ADJ O
antibodies NOUN O
) PUNCT O
specific ADJ O
for ADP O
each DET O
AGA PROPN B-AC
with ADP O
subsequent ADJ O
data NOUN O
analysis NOUN O
. PUNCT O

Methylation NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
PCR NOUN I-LF
, PUNCT O
while SCONJ O
robust ADJ O
, PUNCT O
is AUX O
extremely ADV O
sensitive ADJ O
and CCONJ O
can AUX O
detect VERB O
methylated VERB O
sequences NOUN O
in ADP O
the DET O
presence NOUN O
of ADP O
large ADJ O
amounts NOUN O
of ADP O
unmethylated VERB O
DNA NOUN O
. PUNCT O
We PRON O
used VERB O
sodium NOUN O
bisulfite NOUN O
DNA NOUN O
sequencing NOUN O
to PART O
confirm VERB O
that SCONJ O
the DET O
MSP PROPN B-AC
primer NOUN O
sets NOUN O
used VERB O
in ADP O
these DET O
studies NOUN O
amplified VERB O
the DET O
appropriate ADJ O
target NOUN O
sequences NOUN O
and CCONJ O
that SCONJ O
these DET O
sites NOUN O
were AUX O
bona ADJ O
fide ADJ O
hypermethylated ADJ O
CpG NOUN O
islands NOUN O
. PUNCT O

C PROPN O
, PUNCT O
CFP PROPN B-AC
tag NOUN O
; PUNCT O
CC1 PROPN B-AC
, PUNCT O
coiled NOUN B-LF
- PUNCT I-LF
coil NOUN I-LF
1 NUM I-LF
; PUNCT O
CFP PROPN B-AC
, PUNCT O
cyan NOUN B-LF
fluorescent NOUN I-LF
protein NOUN I-LF
; PUNCT O
EF NOUN B-AC
- PUNCT B-AC
SAM PROPN B-AC
, PUNCT O
EF NOUN B-LF
- PUNCT I-LF
hand NOUN I-LF
and CCONJ I-LF
sterile ADJ I-LF
alpha NOUN I-LF
motif NOUN I-LF
domain NOUN I-LF
; PUNCT O
K PROPN O
, PUNCT O
lysine NOUN O
- PUNCT O
rich ADJ O
region NOUN O
; PUNCT O
NT PROPN B-AC
, PUNCT O
N PROPN B-LF
terminus NOUN I-LF
; PUNCT O
PM PROPN B-AC
, PUNCT O
plasma NOUN B-LF
membrane NOUN I-LF
; PUNCT O
SC PROPN B-AC
, PUNCT O
STIM1 PROPN B-LF
- PUNCT I-LF
CC1 PROPN I-LF
construct NOUN I-LF
; PUNCT O
SOAR PROPN B-AC
, PUNCT O
STIM PROPN B-LF
- PUNCT I-LF
Orai NOUN I-LF
– PUNCT I-LF
activating VERB I-LF
region NOUN I-LF
; PUNCT O
SOAR1L PROPN O
, PUNCT O
STIM1(343–491 NUM O
) PUNCT O
; PUNCT O
STIM PROPN B-AC
, PUNCT O
stromal NOUN B-LF
interaction NOUN I-LF
molecule NOUN I-LF
; PUNCT O
sα1–4 NOUN O
: PUNCT O
α NOUN O
helix NOUN O
1 NUM O
to PART O
4 NUM O
of ADP O
SOAR PROPN B-AC
region NOUN O
; PUNCT O
TM PROPN B-AC
, PUNCT O
transmembrane NOUN B-LF
region NOUN I-LF
; PUNCT O
Y PROPN O
, PUNCT O
YFP PROPN B-AC
tag NOUN O
; PUNCT O
YFP PROPN B-AC
, PUNCT O
yellow ADJ B-LF
fluorescent NOUN I-LF
protein NOUN I-LF
. PUNCT O

HDV PROPN B-AC
, PUNCT O
Hepatitis PROPN B-LF
Delta PROPN I-LF
Virus PROPN I-LF
. PUNCT O

Herein ADV O
, PUNCT O
we PRON O
build VERB O
up ADP O
a DET O
unique ADJ O
system NOUN O
, PUNCT O
namely ADV O
liquid NOUN B-LF
chromatography NOUN I-LF
gel NOUN B-LF
electrophoresis NOUN I-LF
inductively ADV B-LF
coupled VERB I-LF
plasma NOUN I-LF
mass NOUN I-LF
spectrometry NOUN I-LF
( PUNCT O
LC PROPN B-AC
- PUNCT O
GE PROPN B-AC
- PUNCT O
ICP NOUN B-AC
- PUNCT B-AC
MS PROPN B-AC
) PUNCT O
, PUNCT O
allowing VERB O
34 NUM O
proteins NOUN O
directly ADV O
bound VERB O
by ADP O
silver NOUN O
ions NOUN O
to PART O
be AUX O
identified VERB O
in ADP O
Escherichia PROPN O
coli PROPN O
. PUNCT O

In ADP O
mammals NOUN O
( PUNCT O
upper ADJ O
pathway NOUN O
) PUNCT O
, PUNCT O
electrons NOUN O
from ADP O
NADPH PROPN O
are AUX O
transferred VERB O
to ADP O
an DET O
oxidoreductase NOUN O
flavoenzyme NOUN O
, PUNCT O
either CCONJ O
thioredoxin NOUN B-LF
reductase NOUN I-LF
( PUNCT O
TrxR PROPN B-AC
) PUNCT O
or CCONJ O
glutathione NOUN B-LF
reductase NOUN I-LF
( PUNCT O
GR PROPN B-AC
) PUNCT O
. PUNCT O
Electrons NOUN O
are AUX O
then ADV O
transferred VERB O
from ADP O
the DET O
oxidoreductase NOUN O
flavoenzyme NOUN O
to ADP O
the DET O
appropriate ADJ O
electron NOUN O
carrier NOUN O
, PUNCT O
either CCONJ O
oxidized VERB O
thioredoxin NOUN B-LF
( PUNCT O
Trx PROPN B-AC
- PUNCT O
S2 PROPN O
) PUNCT O
or CCONJ O
glutathione NOUN B-LF
disulfide NOUN I-LF
( PUNCT O
GSSG PROPN B-AC
) PUNCT O
converting VERB O
them PRON O
to ADP O
reduced VERB O
thioredoxin NOUN B-LF
( PUNCT O
Trx-[SH]2 PROPN B-AC
) PUNCT O
or CCONJ O
glutathione NOUN B-LF
( PUNCT O
GSH PROPN B-AC
) PUNCT O
, PUNCT O
respectively ADV O
. PUNCT O

Tuberculosis NOUN B-LF
( PUNCT O
TB PROPN B-AC
) PUNCT O
remains VERB O
as ADP O
one NUM O
of ADP O
the DET O
main ADJ O
causes NOUN O
of ADP O
deaths NOUN O
among ADP O
people NOUN B-LF
living VERB I-LF
with ADP I-LF
HIV PROPN I-LF
( PUNCT O
PLHIV PROPN B-AC
) PUNCT O
. PUNCT O

We PRON O
observed VERB O
32 NUM O
sequence NOUN B-LF
types NOUN I-LF
( PUNCT O
STs NOUN B-AC
) PUNCT O
among ADP O
the DET O
132 NUM O
Bordetella PROPN O
isolates NOUN O
. PUNCT O

BC PROPN B-AC
, PUNCT O
breast NOUN B-LF
cancer NOUN I-LF
; PUNCT O
CI PROPN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
HDL NOUN B-AC
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
; PUNCT O
IVW NOUN O
, PUNCT O
inverse NOUN O
- PUNCT O
variance NOUN O
weighted VERB O
; PUNCT O
LDL NOUN B-AC
, PUNCT O
low ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
; PUNCT O
MR NOUN B-AC
, PUNCT O
Mendelian ADJ B-LF
randomization NOUN I-LF
; PUNCT O
MVP PROPN B-AC
, PUNCT O
Million PROPN B-LF
Veteran PROPN I-LF
Program PROPN I-LF
; PUNCT O
OR NOUN B-AC
, PUNCT O
odds NOUN B-LF
ratio NOUN I-LF
; PUNCT O
TC NOUN B-AC
, PUNCT O
total ADJ B-LF
cholesterol NOUN I-LF
; PUNCT O
TG NOUN B-AC
, PUNCT O
triglyceride NOUN B-LF
. PUNCT O

PMI PROPN B-AC
, PUNCT O
President PROPN B-LF
’s PART I-LF
Malaria PROPN I-LF
Initiative PROPN I-LF
. PUNCT O

However ADV O
, PUNCT O
no DET O
labeled VERB O
cells NOUN O
were AUX O
observed VERB O
in ADP O
TRPV1 PROPN B-AC
knock VERB B-LF
- PUNCT I-LF
out NOUN I-LF
( PUNCT O
KO PROPN B-AC
) PUNCT O
mice NOUN O
( PUNCT O
Fig PROPN O
1B NUM O
) PUNCT O
. PUNCT O
Additionally ADV O
, PUNCT O
western ADJ O
blot NOUN O
analysis NOUN O
showed VERB O
a DET O
TRPV1 PROPN B-AC
- PUNCT O
positive ADJ O
signal NOUN O
in ADP O
lysates NOUN O
from ADP O
the DET O
ARC PROPN B-AC
of ADP O
control NOUN O
but CCONJ O
not PART O
TRPV1 PROPN B-AC
KO PROPN B-AC
mice NOUN O
( PUNCT O
Fig PROPN O
1C NUM O
) PUNCT O
. PUNCT O
Importantly ADV O
, PUNCT O
immunostaining NOUN O
, PUNCT O
quantitative ADJ B-LF
polymerase NOUN I-LF
chain NOUN I-LF
reaction NOUN I-LF
( PUNCT O
qPCR PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
western ADJ O
blot NOUN O
analysis NOUN O
showed VERB O
no DET O
expression NOUN O
of ADP O
TRPV1 PROPN B-AC
receptors NOUN O
around ADP O
the DET O
ARC PROPN B-AC
( PUNCT O
S4B PROPN O
, PUNCT O
S4C PROPN O
and CCONJ O
S4D PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

CAM PROPN B-AC
, PUNCT O
CamK2a PROPN B-LF
; PUNCT O
NS PROPN O
, PUNCT O
not PART O
significant ADJ O
; PUNCT O
P PROPN O
, PUNCT O
postnatal ADJ O
day NOUN O
; PUNCT O
USP PROPN B-AC
, PUNCT O
ubiquitin NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
protease NOUN I-LF
; PUNCT O
USV PROPN B-AC
, PUNCT O
ultrasonic ADJ B-LF
vocalization NOUN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ O
- PUNCT O
type NOUN O
. PUNCT O

A DET O
significant ADJ O
minority NOUN O
( PUNCT O
around ADV O
3 NUM O
% NOUN O
) PUNCT O
of ADP O
EC PROPN B-AC
are AUX O
caused VERB O
by ADP O
an DET O
inherited VERB O
genetic ADJ O
predisposition NOUN O
called VERB O
Lynch PROPN B-LF
syndrome NOUN I-LF
( PUNCT O
LS PROPN B-AC
) PUNCT O
. PUNCT O

SES PROPN B-AC
, PUNCT O
socioeconomic ADJ B-LF
status NOUN I-LF
. PUNCT O

BC PROPN B-AC
, PUNCT O
betweenness NOUN B-LF
centrality NOUN I-LF
. PUNCT O

Please INTJ O
see VERB O
page NOUN O
12 NUM O
, PUNCT O
Methods NOUN O
/ SYM O
Outcome NOUN O
measures NOUN O
: PUNCT O
Lines NOUN O
243 NUM O
- PUNCT O
246 NUM O
“ PUNCT O
The DET O
primary ADJ O
outcome NOUN O
of ADP O
interest NOUN O
was AUX O
ICU PROPN B-AC
- PUNCT B-AC
LOS PROPN B-AC
. PUNCT O
Secondary ADJ O
outcomes NOUN O
included VERB O
PaO2 NOUN B-AC
, PUNCT O
the DET O
ratio NOUN O
of ADP O
the DET O
partial ADJ B-LF
pressure NOUN I-LF
of ADP I-LF
arterial ADJ I-LF
oxygen NOUN I-LF
and CCONJ O
fraction NOUN B-LF
of ADP I-LF
inspired ADJ I-LF
oxygen NOUN I-LF
( PUNCT O
PaO2 NOUN B-AC
/ SYM O
FiO2 NOUN B-AC
) PUNCT O
, PUNCT O
PaCO2 NOUN B-AC
, PUNCT O
airway NOUN O
clearance NOUN O
, PUNCT O
the DET O
incidence NOUN O
of ADP O
pneumonia NOUN O
, PUNCT O
respiratory ADJ O
rate NOUN O
, PUNCT O
and CCONJ O
pulmonary ADJ O
atelectasis NOUN O
. PUNCT O
” PUNCT O

GLP-1 NOUN B-AC
, PUNCT O
glucagon NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
peptide NOUN I-LF
1 NUM I-LF
; PUNCT O
PYY3 NOUN B-AC
- PUNCT B-AC
36 NUM B-AC
, PUNCT O
peptide NOUN B-LF
YY3 NOUN I-LF
- PUNCT I-LF
36 NUM I-LF
. PUNCT O

Abbreviations NOUN O
: PUNCT O
cCBT PROPN B-AC
, PUNCT O
computerised ADJ B-LF
cognitive ADJ I-LF
- PUNCT I-LF
behaviour NOUN I-LF
therapy NOUN I-LF
; PUNCT O
OCD PROPN B-AC
, PUNCT O
obsessive ADJ B-LF
- PUNCT I-LF
compulsive ADJ I-LF
disorder NOUN I-LF
. PUNCT O

IR PROPN B-AC
, PUNCT O
ionotropic ADJ B-LF
receptor NOUN I-LF
; PUNCT O
qPCR NOUN B-AC
, PUNCT O
quantitative ADJ B-LF
PCR NOUN I-LF
. PUNCT O

BP PROPN B-AC
, PUNCT O
blood NOUN B-LF
pressure NOUN I-LF
; PUNCT O
CARDIoGRAMplusC4D PROPN B-AC
, PUNCT O
Coronary PROPN B-LF
ARtery PROPN I-LF
DIsease PROPN I-LF
Genome PROPN I-LF
wide ADJ I-LF
Replication PROPN I-LF
and CCONJ I-LF
Meta PROPN I-LF
- PUNCT I-LF
analysis PROPN I-LF
( PUNCT I-LF
CARDIoGRAM PROPN I-LF
) PUNCT I-LF
plus CCONJ I-LF
The DET I-LF
Coronary PROPN I-LF
Artery PROPN I-LF
Disease PROPN I-LF
( PUNCT I-LF
C4D PROPN I-LF
) PUNCT I-LF
Genetics PROPN I-LF
consortium NOUN I-LF
; PUNCT O
FDR PROPN B-AC
, PUNCT O
false ADJ B-LF
discovery NOUN I-LF
rate NOUN I-LF
; PUNCT O
GLGC PROPN B-AC
, PUNCT O
Global PROPN B-LF
Lipids PROPN I-LF
Genetic PROPN I-LF
Consortium PROPN I-LF
; PUNCT O
GRS PROPN B-AC
, PUNCT O
polygenic ADJ B-LF
risk NOUN I-LF
score NOUN I-LF
; PUNCT O
GUGC PROPN B-AC
, PUNCT O
Global PROPN O
Urate PROPN O
Genetic PROPN O
Consortium PROPN O
; PUNCT O
GWAS PROPN B-AC
, PUNCT O
genome NOUN B-LF
- PUNCT I-LF
wide ADJ I-LF
association NOUN I-LF
study NOUN I-LF
; PUNCT O
ICBP PROPN B-AC
, PUNCT O
International PROPN B-LF
Consortium PROPN I-LF
for ADP I-LF
Blood PROPN I-LF
Pressure PROPN I-LF
; PUNCT O
ISGC PROPN B-AC
, PUNCT O
Ischaemic PROPN B-LF
stroke NOUN I-LF
Genetic PROPN I-LF
Consortium PROPN I-LF
; PUNCT O
MR PROPN B-AC
IVW PROPN B-AC
, PUNCT O
inverse ADJ B-LF
variance NOUN I-LF
weighted VERB I-LF
mendelian ADJ I-LF
randomization NOUN I-LF
; PUNCT O
MR PROPN B-AC
- PUNCT B-AC
MoE PROPN B-AC
, PUNCT O
a DET B-LF
mixture NOUN I-LF
- PUNCT I-LF
of ADP I-LF
- PUNCT I-LF
experts NOUN I-LF
machine NOUN I-LF
learning NOUN I-LF
framework NOUN I-LF
of ADP I-LF
mendelian ADJ I-LF
randomization NOUN I-LF
; PUNCT O
PheWAS PROPN B-AC
, PUNCT O
phenome NOUN B-LF
- PUNCT I-LF
wide ADJ I-LF
association NOUN I-LF
study NOUN I-LF
; PUNCT O
PP PROPN B-AC
, PUNCT O
posterior ADJ B-LF
probability NOUN I-LF
; PUNCT O
TreeWAS PROPN B-AC
, PUNCT O
tree NOUN B-LF
- PUNCT I-LF
structured ADJ I-LF
phenotypic ADJ I-LF
model NOUN I-LF
. PUNCT O

Alternatively ADV O
, PUNCT O
we PRON O
transiently ADV O
expressed VERB O
35S PROPN O
: PROPN O
FTIP1 PROPN B-AC
: PROPN O
GFP PROPN B-AC
with ADP O
various ADJ O
fluorescent ADJ O
protein NOUN O
- PUNCT O
tagged VERB O
organelle NOUN O
markers NOUN O
in ADP O
N. PROPN O
benthamiana PROPN O
leaf NOUN O
epidermal ADJ O
cells NOUN O
and CCONJ O
found VERB O
that SCONJ O
FTIP1 PROPN B-AC
: PROPN O
GFP PROPN B-AC
was AUX O
mostly ADV O
colocalized VERB O
with ADP O
an DET O
endoplasmic ADJ B-LF
reticulum NOUN I-LF
( PUNCT O
ER PROPN B-AC
) PUNCT O
marker NOUN O
( PUNCT O
Figure NOUN O
3B NUM O
, PUNCT O
C NOUN O
; PUNCT O
Figure NOUN O
S6 NOUN O
) PUNCT O
[ PUNCT O
17 NUM O
] PUNCT O
. PUNCT O

Robust ADJ O
LTP NOUN B-AC
of ADP O
excitatory ADJ O
synaptic ADJ O
transmission NOUN O
could AUX O
be AUX O
evoked VERB O
by ADP O
high ADJ B-LF
- PUNCT I-LF
frequency NOUN I-LF
stimulations NOUN I-LF
( PUNCT O
HFS PROPN B-AC
: PUNCT O
four NUM O
trains NOUN O
of ADP O
100 NUM O
stimuli NOUN O
at ADP O
100 NUM O
Hz NOUN O
) PUNCT O
in ADP O
WT PROPN B-AC
animals NOUN O
. PUNCT O

A PROPN O
, PUNCT O
aphidicolin NOUN O
; PUNCT O
DRAQ5 PROPN O
, PUNCT O
deep ADJ O
red ADJ O
anthraquinone NOUN O
5 NUM O
; PUNCT O
hdac1 PROPN B-AC
, PUNCT O
histone NOUN B-LF
- PUNCT I-LF
deacetylase NOUN I-LF
1 NUM I-LF
; PUNCT O
hpf NOUN B-AC
, PUNCT O
hours NOUN B-LF
post ADP I-LF
fertilization NOUN I-LF
; PUNCT O
HU PROPN O
, PUNCT O
hydroxyurea NOUN O
; PUNCT O
n.s PROPN O
. PUNCT O
, PUNCT O
not PART O
significant ADJ O
; PUNCT O
PSE PROPN B-AC
, PUNCT O
pseudostratified ADJ B-LF
epithelium NOUN I-LF
. PUNCT O

N1+/-;N2+/- NOUN B-AC
, PUNCT O
Notch1 PROPN B-LF
/ SYM O
Notch2 PROPN B-LF
RA NOUN O
hemizygous ADJ O
; PUNCT O
N2RA PROPN B-AC
/ SYM O
RA NOUN O
, PUNCT O
Notch2 PROPN B-LF
RA NOUN O
homozygous ADJ O
; PUNCT O
P0 NOUN O
- PUNCT O
1 NUM O
, PUNCT O
postnatal ADJ O
day NOUN O
0–1 NUM O
; PUNCT O
RA NOUN O
, PUNCT O
Arg PROPN O
( PUNCT O
N1R1974 PROPN O
/ SYM O
N2R1934 PROPN O
) PUNCT O
to ADP O
Ala PROPN O
substitution NOUN O
; PUNCT O
wt NOUN O
, PUNCT O
wild ADJ O
- PUNCT O
type NOUN O
. PUNCT O

R NOUN O
: PUNCT O
Reproductive ADJ O
number NOUN O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN B-AC
, PUNCT O
95 NUM O
% NOUN O
Confidence NOUN B-LF
Interval NOUN I-LF
. PUNCT O

Molecular ADJ O
confirmation NOUN O
of ADP O
the DET O
role NOUN O
of ADP O
Fyn PROPN O
and CCONJ O
c NOUN O
- PUNCT O
Cbl NOUN O
in ADP O
the DET O
effects NOUN O
of ADP O
MeHg PROPN B-AC
on ADP O
levels NOUN O
of ADP O
PDGFRα PROPN B-AC
was AUX O
obtained VERB O
by ADP O
expression NOUN O
of ADP O
dominant ADJ O
negative ADJ O
c NOUN O
- PUNCT O
Cbl NOUN O
, PUNCT O
or CCONJ O
small ADJ O
inhibitory ADJ B-LF
RNA NOUN I-LF
( PUNCT O
RNAi NOUN B-AC
) PUNCT O
for ADP O
Fyn PROPN O
or CCONJ O
Cbl NOUN O
, PUNCT O
in ADP O
MeHg PROPN B-AC
- PUNCT O
exposed VERB O
O-2A NOUN B-AC
/ SYM B-AC
OPCs NOUN O
. PUNCT O
Expression NOUN O
of ADP O
the DET O
dominant ADJ O
- PUNCT O
negative ADJ O
( PUNCT O
DN PROPN O
) PUNCT O
70z NOUN O
mutant NOUN O
of ADP O
c NOUN O
- PUNCT O
Cbl NOUN O
[ X O
106–108 NUM O
] X O
in ADP O
O-2A NOUN B-AC
/ SYM B-AC
OPCs NOUN O
prevented VERB O
MeHg PROPN B-AC
- PUNCT O
induced VERB O
reductions NOUN O
in ADP O
levels NOUN O
of ADP O
PDGFRα PROPN B-AC
( PUNCT O
Figure NOUN O
6A NUM O
) PUNCT O
. PUNCT O
Reduction NOUN O
in ADP O
levels NOUN O
of ADP O
Fyn PROPN O
protein NOUN O
by ADP O
introduction NOUN O
of ADP O
Fyn PROPN O
- PUNCT O
specific ADJ O
small ADJ B-LF
interfering ADJ I-LF
RNA NOUN I-LF
( PUNCT O
siRNA NOUN B-AC
) PUNCT O
constructs NOUN O
( PUNCT O
Figure NOUN O
6B NUM O
) PUNCT O
also ADV O
protected VERB O
against ADP O
MeHg PROPN B-AC
- PUNCT O
induced VERB O
reductions NOUN O
in ADP O
levels NOUN O
of ADP O
PDGFRα PROPN B-AC
( PUNCT O
Figure NOUN O
6C NUM O
) PUNCT O
, PUNCT O
as SCONJ O
predicted VERB O
by ADP O
the DET O
hypothesis NOUN O
that SCONJ O
MeHg PROPN B-AC
- PUNCT O
induced VERB O
activation NOUN O
of ADP O
Fyn PROPN O
mechanistically ADV O
precedes VERB O
reductions NOUN O
in ADP O
receptor NOUN O
levels NOUN O
. PUNCT O

Data PROPN O
are AUX O
included VERB O
in ADP O
S2 PROPN O
Data PROPN O
. PUNCT O
4HNE NOUN B-AC
, PUNCT O
4 NUM B-LF
- PUNCT I-LF
hydroxynonenal NOUN I-LF
; PUNCT O
BMDM PROPN B-AC
, PUNCT O
bone NOUN B-LF
marrow NOUN I-LF
– PUNCT I-LF
derived VERB I-LF
macrophage NOUN I-LF
; PUNCT O
LPS PROPN B-AC
, PUNCT O
lipopolysaccharides NOUN B-LF
; PUNCT O
RT NOUN B-AC
- PUNCT B-AC
qPCR NOUN B-AC
, PUNCT O
reverse ADJ B-LF
transcriptase NOUN I-LF
quantitative ADJ I-LF
PCR NOUN I-LF
. PUNCT O

Matching PROPN O
Methods NOUN O
: PUNCT O
What PRON O
the DET O
aim NOUN O
of ADP O
taking VERB O
into ADP O
account NOUN O
the DET O
" PUNCT O
similar ADJ O
defined VERB B-LF
daily ADJ I-LF
dose NOUN I-LF
( PUNCT O
DDD)-prescription NOUN B-AC
of ADP O
the DET O
studied VERB O
drug NOUN O
" PUNCT O
for ADP O
identifying VERB O
controls NOUN O
? PUNCT O

Next PROPN B-LF
Generation PROPN I-LF
Sequencing PROPN I-LF
( PUNCT O
NGS PROPN B-AC
) PUNCT O
libraries NOUN O
were AUX O
prepared VERB O
and CCONJ O
polymerase NOUN B-LF
chain NOUN I-LF
reaction NOUN I-LF
( PUNCT O
PCR)/reverse NOUN B-AC
transcription NOUN O
- PUNCT O
PCR NOUN B-AC
( PUNCT O
RT NOUN B-AC
- PUNCT B-AC
PCR NOUN B-AC
) PUNCT O
were AUX O
performed VERB O
within ADP O
7 NUM O
days NOUN O
. PUNCT O

Small ADJ B-LF
bowel NOUN I-LF
adenocarcinoma NOUN I-LF
( PUNCT O
SBA PROPN B-AC
) PUNCT O
is AUX O
a DET O
malignant ADJ O
tumor NOUN O
of ADP O
the DET O
small ADJ O
intestine NOUN O
mucosa NOUN O
that PRON O
is AUX O
mostly ADV O
located VERB O
around ADP O
the DET O
duodenal ADJ O
papilla NOUN O
. PUNCT O

CAD NOUN B-AC
= PUNCT O
coronary ADJ B-LF
artery NOUN I-LF
disease NOUN I-LF
, PUNCT O
HR NOUN B-AC
= PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
, PUNCT O
95%CI NOUN B-AC
= PUNCT O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
, PUNCT O
MI NOUN B-AC
= PUNCT O
myocardial ADJ B-LF
infarction NOUN I-LF
, PUNCT O
HF NOUN B-AC
= PUNCT O
heart NOUN B-LF
failure NOUN I-LF
. PUNCT O

Mean ADJ O
age NOUN O
of ADP O
participants NOUN O
was AUX O
56.3 NUM O
years NOUN O
( PUNCT O
Standard PROPN B-LF
Deviation PROPN I-LF
( PUNCT O
SD PROPN B-AC
) PUNCT O
= SYM O
11.5 NUM O
) PUNCT O
, PUNCT O
which PRON O
ranges VERB O
between ADP O
30–86 NUM O
years NOUN O
. PUNCT O

PE PROPN B-AC
is AUX O
also ADV O
frequently ADV O
co ADJ O
- ADJ O
morbid ADJ O
with ADP O
other ADJ O
conditions NOUN O
such ADJ O
as ADP O
intra ADJ B-LF
- ADJ I-LF
uterine ADJ I-LF
growth NOUN I-LF
restriction NOUN I-LF
( PUNCT O
IUGR PROPN B-AC
) PUNCT O
or CCONJ O
small ADJ B-LF
- ADJ I-LF
for ADP I-LF
- ADJ I-LF
gestational ADJ I-LF
age NOUN I-LF
( PUNCT O
SGA PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
symptoms NOUN O
can AUX O
often ADV O
“ PUNCT O
mimic VERB O
” PUNCT O
, PUNCT O
or CCONJ O
overlap VERB O
, PUNCT O
with ADP O
those PRON O
of ADP O
other ADJ O
syndromes NOUN O
such ADJ O
as ADP O
HELPP PROPN O
syndrome NOUN O
— PUNCT O
making VERB O
diagnosis NOUN O
a DET O
distinctly ADV O
non ADJ O
- ADJ O
trivial ADJ O
matter NOUN O
[ PUNCT O
13 NUM O
] PUNCT O
. PUNCT O

Several ADJ O
professional ADJ O
societies NOUN O
, PUNCT O
including VERB O
AAGL PROPN B-AC
( PUNCT O
Elevating PROPN B-LF
Gynecologic PROPN I-LF
Surgery PROPN I-LF
, PUNCT I-LF
founded VERB I-LF
as ADP I-LF
American PROPN I-LF
Association PROPN I-LF
of ADP I-LF
Gynecologic PROPN I-LF
Laparoscopists PROPN I-LF
) PUNCT O
and CCONJ O
American PROPN B-LF
College PROPN I-LF
of ADP I-LF
Obstetricians PROPN I-LF
and CCONJ I-LF
Gynecologists PROPN I-LF
( PUNCT O
ACOG PROPN B-AC
) PUNCT O
, PUNCT O
subsequently ADV O
followed VERB O
up ADP O
with ADP O
practice NOUN O
guidelines NOUN O
and CCONJ O
committee NOUN O
opinions NOUN O
to PART O
address VERB O
this DET O
issue NOUN O
, PUNCT O
along ADP O
with ADP O
updates NOUN O
in ADP O
the DET O
literature NOUN O
[ PUNCT O
9 NUM O
, PUNCT O
10 NUM O
] PUNCT O
. PUNCT O

Conditional ADJ O
logistic ADJ O
regression NOUN O
was AUX O
used VERB O
, PUNCT O
adjusting VERB O
for ADP O
major ADJ O
risk NOUN O
factors NOUN O
for ADP O
GDM PROPN B-AC
. PUNCT O
After ADP O
adjusting VERB O
for ADP O
covariates NOUN O
, PUNCT O
individual ADJ O
n-3 NOUN O
eicosapentaenoic NOUN B-LF
acid NOUN I-LF
( PUNCT O
EPA PROPN B-AC
) PUNCT O
, PUNCT O
docosapentaenoic NOUN B-LF
acid NOUN I-LF
( PUNCT O
DPA PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
docosahexaenoic NOUN B-LF
acid NOUN I-LF
( PUNCT O
DHA PROPN B-AC
) PUNCT O
were AUX O
inversely ADV O
correlated VERB O
with ADP O
insulin NOUN O
- PUNCT O
resistance NOUN O
markers NOUN O
, PUNCT O
whereas SCONJ O
individual ADJ O
n-6 NOUN O
dihomo NOUN B-LF
- PUNCT I-LF
gamma NOUN I-LF
- PUNCT I-LF
linolenic NOUN I-LF
acid NOUN I-LF
( PUNCT O
DGLA PROPN B-AC
) PUNCT O
was AUX O
positively ADV O
correlated VERB O
with ADP O
insulin NOUN O
- PUNCT O
resistance NOUN O
markers NOUN O
. PUNCT O

DNL PROPN B-AC
, PUNCT O
de X B-LF
novo X I-LF
lipogenesis NOUN I-LF
. PUNCT O

The DET O
air NOUN O
pollution NOUN O
data NOUN O
was AUX O
obtained VERB O
from ADP O
UK PROPN O
’s PART O
Department PROPN B-LF
for ADP I-LF
Environment PROPN I-LF
, PUNCT I-LF
Food PROPN I-LF
and CCONJ I-LF
Rural PROPN I-LF
Affairs PROPN I-LF
( PUNCT O
DEFRA PROPN B-AC
) PUNCT O
and CCONJ O
is AUX O
freely ADV O
available ADJ O
from ADP O
their PRON O
website NOUN O
at ADP O
https://uk-air.defra.gov.uk/data/pcm-data X O
. PUNCT O

ADAR1 PROPN B-AC
still ADV O
edits VERB O
some PRON O
of ADP O
it PRON O
( PUNCT O
blue ADJ O
) PUNCT O
, PUNCT O
but CCONJ O
unedited ADJ O
dsRNA PROPN B-AC
activates VERB O
innate ADJ O
immunity NOUN O
( PUNCT O
red ADJ O
) PUNCT O
. PUNCT O
( PUNCT O
C PROPN O
) PUNCT O
Schematic ADJ O
representation NOUN O
of ADP O
the DET O
generation NOUN O
of ADP O
immunogenic ADJ O
duplex NOUN O
RNA NOUN O
( PUNCT O
panhandle NOUN O
structures NOUN O
) PUNCT O
during ADP O
viral ADJ O
infection NOUN O
and CCONJ O
the DET O
impact NOUN O
of ADP O
ADAR1 PROPN B-AC
on ADP O
PKR- PROPN B-AC
and CCONJ O
MDA-5 PROPN B-AC
- PUNCT O
mediated VERB O
innate ADJ O
immunity NOUN O
activation NOUN O
by ADP O
these DET O
RNAs NOUN O
. PUNCT O
ADAR1 PROPN B-AC
, PUNCT O
adenosine NOUN B-LF
deaminase NOUN I-LF
acting VERB I-LF
on ADP I-LF
RNA NOUN I-LF
1 NUM I-LF
; PUNCT O
DI PROPN B-AC
, PUNCT O
defective ADJ B-LF
interfering VERB I-LF
; PUNCT O
dsRNA PROPN B-AC
, PUNCT O
double ADJ O
- PUNCT O
stranded ADJ O
RNA NOUN O
; PUNCT O
IFN PROPN B-AC
, PUNCT O
interferon NOUN B-LF
; PUNCT O
MDA-5 PROPN B-AC
, PUNCT O
melanoma NOUN B-LF
differentiation NOUN I-LF
– PUNCT I-LF
associated VERB I-LF
gene NOUN I-LF
5 NUM I-LF
; PUNCT O
MeV PROPN B-AC
- PUNCT B-AC
CKO PROPN B-AC
, PUNCT O
MeV PROPN B-LF
unable ADJ I-LF
to PART I-LF
express VERB I-LF
C PROPN I-LF
protein NOUN I-LF
; PUNCT O
PKR PROPN B-AC
, PUNCT O
protein NOUN B-LF
kinase NOUN I-LF
R. NOUN I-LF

Hunter PROPN O
and CCONJ O
colleagues NOUN O
[ X O
4 X O
] X O
reported VERB O
highly ADV O
variable ADJ O
frequencies NOUN O
of ADP O
disomes NOUN O
for ADP O
different ADJ O
chromosomes NOUN B-LF
, PUNCT O
ranging VERB O
from ADP O
0 NUM O
% PUNCT O
( PUNCT O
chromosome NOUN B-LF
[ X O
Chr NOUN B-AC
] X O
VI NOUN O
) PUNCT O
to ADP O
27.2 NUM O
% PUNCT O
( PUNCT O
Chr NOUN B-AC
II NUM O
) PUNCT O
with ADP O
a DET O
mean ADJ O
of ADP O
12.2 NUM O
% PUNCT O
, PUNCT O
corresponding VERB O
to ADP O
1.95 NUM O
disomes NOUN O
per ADP O
cell NOUN O
( PUNCT O
mean ADJ O
number NOUN O
of ADP O
disomes NOUN O
= PUNCT O
16 NUM O
× SYM O
mean ADJ O
frequency NOUN O
of ADP O
nondisjunction NOUN O
) PUNCT O
. PUNCT O

CEDIF PROPN B-AC
, PUNCT O
central ADJ B-LF
dogma NOUN I-LF
information NOUN I-LF
flow NOUN I-LF
; PUNCT O
CT PROPN B-AC
, PUNCT O
constant ADJ B-LF
time NOUN I-LF
; PUNCT O
R.E. PROPN O
, PUNCT O
relative ADJ O
expression NOUN O
; PUNCT O
RNA NOUN B-AC
- PROPN B-AC
Seq PROPN B-AC
, PUNCT O
RNA NOUN B-LF
sequencing NOUN I-LF
; PUNCT O
STRING PROPN B-AC
, PUNCT O
Search PROPN B-LF
Tool PROPN I-LF
for ADP I-LF
the DET I-LF
Retrieval PROPN I-LF
of ADP I-LF
Interacting PROPN I-LF
Genes PROPN I-LF
/ SYM I-LF
Proteins NOUN I-LF
; PUNCT O
UPR PROPN B-AC
, PUNCT O
Unfolded PROPN B-LF
Protein PROPN I-LF
Response PROPN I-LF
; PUNCT O
XBP1 PROPN O
, PUNCT O
X PROPN O
- PROPN O
box PROPN O
Binding PROPN O
Protein PROPN O
1 NUM O
; PUNCT O
ZT PROPN B-AC
, PUNCT O
Zeitgeber PROPN B-LF
time NOUN I-LF
. PUNCT O

For ADP O
example NOUN O
, PUNCT O
a DET O
point NOUN O
mutation NOUN O
introducing VERB O
a DET O
uORF NOUN B-AC
in ADP O
the DET O
5′ NUM O
UTR NOUN B-AC
of ADP O
CDKN2A PROPN B-AC
decreases VERB O
cyclin NOUN B-LF
- PUNCT I-LF
dependent ADJ I-LF
kinase NOUN I-LF
inhibitor NOUN I-LF
2A NOUN I-LF
( PUNCT O
CDKN2A PROPN B-AC
) PUNCT O
protein NOUN O
level NOUN O
and CCONJ O
causes VERB O
melanoma NOUN O
[ PUNCT O
50 NUM O
, PUNCT O
51 NUM O
] PUNCT O
. PUNCT O

Data NOUN O
are AUX O
available ADJ O
at ADP O
https://github.com/ZhixuanXu/Nonadaptive-alternative-TSSs X B-AC
. PUNCT O
BRE PROPN B-AC
, PUNCT O
TFIIB NOUN B-LF
recognition NOUN I-LF
element NOUN I-LF
; PUNCT O
DPE PROPN B-AC
, PUNCT O
downstream ADJ B-LF
promoter NOUN I-LF
element NOUN I-LF
; PUNCT O
INR PROPN B-AC
, PUNCT O
initiator NOUN B-LF
; PUNCT O
nt NOUN O
, PUNCT O
nucleotide NOUN O
; PUNCT O
TATA PROPN O
, PUNCT O
TATA PROPN O
box NOUN O
; PUNCT O
TSS PROPN B-AC
, PUNCT O
transcription NOUN B-LF
start NOUN I-LF
site NOUN I-LF
. PUNCT O

EF PROPN B-AC
, PUNCT O
ejection NOUN B-LF
fraction NOUN I-LF
; PUNCT O
CVA PROPN B-AC
, PUNCT O
cerebrovascular ADJ B-LF
accident NOUN I-LF
; PUNCT O
NYHA PROPN B-AC
, PUNCT O
New PROPN B-LF
York PROPN I-LF
Heart PROPN I-LF
Association PROPN I-LF
; PUNCT O
CRP PROPN B-AC
, PUNCT O
C NOUN B-LF
- ADJ I-LF
reactive ADJ I-LF
protein NOUN I-LF
, PUNCT O
BUN PROPN O
, PUNCT O
blood NOUN O
urea NOUN O
nitrogen NOUN O
; PUNCT O
PVD NOUN B-AC
, PUNCT O
peripheral ADJ B-LF
vascular ADJ I-LF
disease NOUN I-LF
; PUNCT O
25(OH)D NOUN B-AC
, PUNCT O
25 NUM B-LF
- ADJ I-LF
hydroxy NOUN I-LF
vitamin NOUN I-LF
D NOUN I-LF

Likelihood NOUN B-LF
Ratio NOUN I-LF
( PUNCT O
LR PROPN B-AC
) PUNCT O
test NOUN O
, PUNCT O
Intra ADJ O
- PUNCT O
class NOUN O
Correlation PROPN O
Coefficient PROPN O
( PUNCT O
ICC PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
Median ADJ O
Odds NOUN O
Ratio NOUN O
( PUNCT O
MOR PROPN O
) PUNCT O
were AUX O
computed VERB O
to PART O
measure VERB O
the DET O
variation NOUN O
of ADP O
anemia NOUN O
across ADP O
clusters NOUN O
. PUNCT O

AKD PROPN B-AC
, PUNCT O
acute ADJ B-LF
kidney NOUN I-LF
disease NOUN I-LF
; PUNCT O
AKI PROPN B-AC
, PUNCT O
acute ADJ B-LF
kidney NOUN I-LF
injury NOUN I-LF
; PUNCT O
CKD PROPN B-AC
, PUNCT O
chronic ADJ B-LF
kidney NOUN I-LF
disease NOUN I-LF
; PUNCT O
NKD PROPN B-AC
, PUNCT O
no DET B-LF
kidney NOUN I-LF
disease NOUN I-LF
. PUNCT O

Rat ADJ O
primary ADJ O
dermal ADJ O
fibroblasts NOUN O
were AUX O
purchased VERB O
from ADP O
the DET O
European PROPN B-LF
Collection PROPN I-LF
of ADP I-LF
Authenticated PROPN I-LF
Cell PROPN I-LF
Cultures PROPN I-LF
( PUNCT O
ECACC PROPN B-AC
) PUNCT O
( PUNCT O
catalogue NOUN O
number NOUN O
06090769 NUM O
) PUNCT O
. PUNCT O

Our PRON O
results NOUN O
from ADP O
Nigeria PROPN O
share VERB O
similarities NOUN O
and CCONJ O
differences NOUN O
with ADP O
results NOUN O
from ADP O
oxygen NOUN O
improvement NOUN O
programs NOUN O
in ADP O
other ADJ O
low- ADJ B-LF
and CCONJ I-LF
middle ADJ I-LF
- PUNCT I-LF
income NOUN I-LF
countries NOUN I-LF
( PUNCT O
LMICs PROPN B-AC
) PUNCT O
[ PUNCT O
3 NUM O
, PUNCT O
6 NUM O
] PUNCT O
. PUNCT O

Pairwise ADJ O
structure NOUN O
alignment NOUN O
programs NOUN O
fall VERB O
into ADP O
three NUM O
broad ADJ O
classes NOUN O
: PUNCT O
the DET O
first ADJ O
class NOUN O
, PUNCT O
to PART O
which PRON O
Matt PROPN O
belongs VERB O
, PUNCT O
are AUX O
aligned VERB B-LF
fragment NOUN I-LF
pair NOUN I-LF
( PUNCT O
AFP PROPN B-AC
) PUNCT O
chaining NOUN O
methods NOUN O
[ X O
13,14 NUM O
] X O
which PRON O
do VERB O
an DET O
all PRON O
- PUNCT O
against ADP O
- PUNCT O
all PRON O
best ADJ O
transformation NOUN O
of ADP O
short ADJ O
protein NOUN O
fragments NOUN O
from ADP O
one NUM O
protein NOUN O
structure NOUN O
onto ADP O
another PRON O
, PUNCT O
and CCONJ O
assemble VERB O
these PRON O
in ADP O
a DET O
geometrically ADV O
consistent ADJ O
fashion NOUN O
. PUNCT O

BMI PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
. PUNCT O

Arch PROPN B-AC
, PUNCT O
archaerhodopsin-3 NOUN B-LF
; PUNCT O
En1 PROPN B-AC
, PUNCT O
engrailed-1 NOUN B-LF
; PUNCT O
tdT PROPN B-AC
, PUNCT O
tdTomato PROPN B-LF
. PUNCT O

AP PROPN B-AC
, PUNCT O
alkaline ADJ B-LF
phosphatase NOUN I-LF
; PUNCT O
ICTP PROPN B-AC
, PUNCT O
C NOUN B-LF
- PUNCT I-LF
telopeptide NOUN I-LF
of ADP I-LF
type-1 NOUN I-LF
collagen NOUN I-LF
; PUNCT O
OPG PROPN B-AC
, PUNCT O
osteoprotegerin NOUN B-LF
; PUNCT O
PTH PROPN B-AC
, PUNCT O
parathyroid NOUN B-LF
hormone NOUN I-LF
; PUNCT O
sRANKL PROPN O
, PUNCT O
soluble ADJ O
receptor NOUN O
activator NOUN O
of ADP O
nuclear ADJ O
factor NOUN O
kappa NOUN O
B PROPN O
ligand NOUN O
; PUNCT O
TP1NP PROPN B-AC
, PUNCT O
total ADJ B-LF
procollagen NOUN I-LF
type-1 NOUN I-LF
intact ADJ I-LF
N NOUN I-LF
- PUNCT I-LF
terminal ADJ I-LF
propeptide NOUN I-LF
; PUNCT O
TRAP5b PROPN B-AC
, PUNCT O
tartrate NOUN B-LF
- PUNCT I-LF
resistant ADJ I-LF
acid NOUN I-LF
phosphatase NOUN I-LF
type NOUN I-LF
5b NUM I-LF
. PUNCT O

A. X O
Correlation NOUN O
between ADP O
RDW PROPN B-AC
and CCONJ O
TNM PROPN O
stage NOUN O
of ADP O
NSCLC PROPN B-AC
. PUNCT O
RDW PROPN B-AC
red ADJ B-LF
blood NOUN I-LF
cell NOUN I-LF
distribution NOUN I-LF
width NOUN I-LF
; PUNCT O
NSCLC PROPN B-AC
non ADJ B-LF
- ADJ I-LF
small ADJ I-LF
cell NOUN I-LF
lung NOUN I-LF
cancer NOUN I-LF
. PUNCT O

Nevertheless ADV O
, PUNCT O
the DET O
characteristics NOUN O
of ADP O
positively ADV B-LF
selected VERB I-LF
genes NOUN I-LF
( PUNCT O
PSGs PROPN B-AC
) PUNCT O
, PUNCT O
have AUX O
not PART O
been AUX O
well ADV O
investigated VERB O
. PUNCT O

GIG PROPN B-AC
is AUX O
a NOUN O
member NOUN O
of ADP O
the DET O
BTB PROPN B-AC
( PUNCT O
Bric PROPN B-LF
- NOUN I-LF
a NOUN I-LF
- NOUN I-LF
brac PROPN I-LF
, PUNCT I-LF
Tramtrack PROPN I-LF
and CCONJ I-LF
Broad)/Kelch PROPN I-LF
superfamily NOUN O
[ PUNCT O
4 NUM O
] PUNCT O
. PUNCT O

See VERB O
Text NOUN O
S3 PROPN O
for ADP O
definitions NOUN O
and CCONJ O
calculations NOUN O
of ADP O
odds NOUN B-LF
ratios NOUN I-LF
( PUNCT O
OR NOUN B-AC
1 NUM O
, PUNCT O
OR NOUN B-AC
2 NUM O
, PUNCT O
and CCONJ O
OR NOUN B-AC
3 NUM O
) PUNCT O
. PUNCT O

In ADP O
this DET O
manner NOUN O
, PUNCT O
we PRON O
defined VERB O
five NUM O
time NOUN B-LF
classes NOUN I-LF
( PUNCT O
TC NOUN B-AC
) PUNCT O
and CCONJ O
color NOUN O
- PUNCT O
coded VERB O
them PRON O
as SCONJ O
follows VERB O
: PUNCT O
TC1 NOUN O
in ADP O
purple NOUN O
: PUNCT O
65–75 NUM O
h NOUN O
after ADP B-LF
egg NOUN I-LF
laying NOUN I-LF
( PUNCT O
AEL NOUN B-AC
) PUNCT O
; PUNCT O
TC2 PROPN O
in ADP O
green NOUN O
: PUNCT O
75–85 NUM O
h NOUN O
AEL NOUN B-AC
; PUNCT O
TC3 PROPN O
in ADP O
orange NOUN O
: PUNCT O
85–95 NUM O
h NOUN O
AEL NOUN B-AC
; PUNCT O
TC4 PROPN O
in ADP O
blue NOUN O
: PUNCT O
95–105 NUM O
h NOUN O
AEL NOUN B-AC
; PUNCT O
TC5 PROPN O
in ADP O
red NOUN O
: PUNCT O
105–120 NUM O
h NOUN O
AEL NOUN B-AC
( PUNCT O
Figure NOUN O
2A NUM O
) PUNCT O
. PUNCT O
Note VERB O
that SCONJ O
timing NOUN O
refers VERB O
to ADP O
hours NOUN O
after ADP B-LF
egg NOUN I-LF
laying NOUN I-LF
and CCONJ O
not PART O
to ADP O
hours NOUN O
after ADP O
hatching NOUN O
; PUNCT O
a DET O
larva NOUN O
of ADP O
70 NUM O
h NOUN O
AEL NOUN B-AC
would AUX O
be AUX O
46 NUM O
- PUNCT O
h NOUN O
- PUNCT O
old ADJ O
after ADP O
hatching NOUN O
. PUNCT O

We PRON O
also ADV O
compared VERB O
the DET O
diagnostic ADJ B-LF
odds NOUN I-LF
ratio NOUN I-LF
( PUNCT O
DOR PROPN B-AC
) PUNCT O
, PUNCT O
heterogeneity NOUN O
in ADP O
DOR PROPN B-AC
, PUNCT O
and CCONJ O
false ADJ B-LF
positive ADJ I-LF
rate NOUN I-LF
( PUNCT O
FPR NOUN B-AC
) PUNCT O
for ADP O
each DET O
signature NOUN O
using VERB O
bivariate ADJ O
meta NOUN O
- NOUN O
analysis NOUN O
. PUNCT O

While SCONJ O
inhibitors NOUN O
of ADP O
both CCONJ O
histone NOUN B-LF
deacetylase NOUN I-LF
( PUNCT O
HDAC PROPN B-AC
) PUNCT O
and CCONJ O
lysine NOUN O
- PUNCT O
specific ADJ O
demethylase-1 NOUN O
( PUNCT O
LSD1 PROPN B-AC
) PUNCT O
subunits NOUN O
of ADP O
the DET O
NuRD PROPN B-AC
complex NOUN O
demonstrate VERB O
single ADJ O
agent NOUN O
activity NOUN O
in ADP O
preclinical ADJ O
models NOUN O
, PUNCT O
combination NOUN O
strategies NOUN O
have AUX O
not PART O
been AUX O
investigated VERB O
. PUNCT O

Unadjusted ADJ O
associations NOUN O
of ADP O
central ADJ O
( PUNCT O
A NOUN O
- PUNCT O
C NOUN O
) PUNCT O
and CCONJ O
peripheral ADJ O
( PUNCT O
D NOUN O
) PUNCT O
pulse NOUN B-LF
wave NOUN I-LF
velocity NOUN I-LF
( PUNCT O
PWV PROPN B-AC
) PUNCT O
measures NOUN O
with ADP O
NT PROPN B-AC
- PUNCT B-AC
proBNP PROPN B-AC
. PUNCT O

Pheochromocytomas NOUN O
can AUX O
arise VERB O
as ADP O
a DET O
result NOUN O
of ADP O
mutations NOUN O
in ADP O
the DET O
following ADJ O
disease NOUN O
- PUNCT O
associated VERB O
genes NOUN O
: PUNCT O
RET PROPN O
in ADP O
multiple ADJ B-LF
endocrine ADJ I-LF
neoplasia NOUN I-LF
type NOUN I-LF
2 NUM I-LF
( PUNCT O
MEN2 PROPN B-AC
) PUNCT O
; PUNCT O
VHL PROPN B-AC
in ADP O
von PROPN B-LF
Hippel PROPN I-LF
- PUNCT I-LF
Lindau PROPN I-LF
disease NOUN I-LF
( PUNCT O
VHL PROPN B-AC
) PUNCT O
; PUNCT O
NF1 PROPN B-AC
in ADP O
neurofibromatosis NOUN B-LF
type NOUN I-LF
1 NUM I-LF
( PUNCT O
NF1 PROPN B-AC
) PUNCT O
; PUNCT O
and CCONJ O
succinate NOUN B-LF
dehydrogenase NOUN I-LF
( PUNCT O
SDH PROPN B-AC
) PUNCT O
subunits NOUN O
B NOUN O
, PUNCT O
C PROPN O
, PUNCT O
or CCONJ O
D NOUN O
in ADP O
familial ADJ O
paraganglioma NOUN O
syndromes NOUN O
type NOUN O
4 NUM O
( PUNCT O
PGL4 PROPN O
) PUNCT O
, PUNCT O
type NOUN O
3 NUM O
( PUNCT O
PGL3 PROPN O
) PUNCT O
, PUNCT O
and CCONJ O
type NOUN O
1 NUM O
( PUNCT O
PGL1 PROPN O
) PUNCT O
, PUNCT O
respectively ADV O
[ PUNCT O
2 NUM O
] PUNCT O
. PUNCT O

Here ADV O
, PUNCT O
we PRON O
have AUX O
carefully ADV O
analyzed VERB O
the DET O
transcription NOUN O
profiles NOUN O
of ADP O
three NUM O
highly ADV O
purified ADJ O
subpopulations NOUN O
within ADP O
the DET O
mouse NOUN O
adult NOUN O
bone NOUN O
marrow NOUN O
lineage−/c NOUN O
- PUNCT O
kit+/Sca1 NOUN O
+ NOUN O
( PUNCT O
KLS PROPN O
) PUNCT O
fraction NOUN O
: PUNCT O
LT PROPN B-AC
- PUNCT O
HSC PROPN B-AC
( PUNCT O
defined VERB O
as ADP O
Thy1.1lo NOUN O
/ SYM O
Flk2− NOUN O
KLS PROPN O
) PUNCT O
, PUNCT O
short ADJ B-LF
- PUNCT I-LF
term NOUN I-LF
( PUNCT O
ST)-HSC PROPN B-AC
( PUNCT O
Thy1.1lo NOUN O
/ SYM O
Flk2 PROPN O
+ NOUN O
KLS PROPN O
) PUNCT O
, PUNCT O
and CCONJ O
multipotent ADJ O
progenitors NOUN O
( PUNCT O
MPP PROPN B-AC
) PUNCT O
( PUNCT O
Thy1.1−/Flk2 NOUN O
+ NOUN O
KLS PROPN O
) PUNCT O
[ PUNCT O
16 NUM O
] PUNCT O
. PUNCT O

Normal ADJ O
( PUNCT O
NF PROPN B-AC
) PUNCT O
and CCONJ O
cancer NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
fibroblasts NOUN I-LF
( PUNCT O
CAFs PROPN B-AC
) PUNCT O
were AUX O
isolated VERB O
previously ADV O
[ X O
1 X O
] X O
from ADP O
female ADJ O
patients NOUN O
with ADP O
ER NOUN B-AC
positive ADJ O
, PUNCT O
HER–2 PROPN B-AC
negative ADJ O
, PUNCT O
grade NOUN O
2 NUM O
ductal ADJ O
NST PROPN O
cancers NOUN O
with ADP O
no DET O
lymph NOUN O
node NOUN O
involvement NOUN O
. PUNCT O

Therefore ADV O
, PUNCT O
the DET O
objective NOUN O
of ADP O
this DET O
study NOUN O
was AUX O
to PART O
simultaneously ADV O
treat VERB O
LCB PROPN B-AC
containing VERB O
a DET O
mix NOUN O
of ADP O
pine NOUN B-LF
bark NOUN I-LF
( PUNCT O
PB PROPN B-AC
) PUNCT O
, PUNCT O
chopped VERB B-LF
paper NOUN I-LF
napkins NOUN I-LF
( PUNCT O
CPN PROPN B-AC
) PUNCT O
and CCONJ O
brewing NOUN B-LF
yeast NOUN I-LF
hydrolysate NOUN I-LF
( PUNCT O
BYH PROPN B-AC
) PUNCT O
and CCONJ O
LDPEoxo PROPN B-AC
employing VERB O
P. PROPN O
ostreatus NOUN O
at ADP O
microcosm NOUN O
scale NOUN O
to PART O
obtain VERB O
oxidized VERB O
LCB PROPN B-AC
and CCONJ O
biotransformed VERB O
plastic NOUN O
as ADP O
RM PROPN B-AC
to PART O
produce VERB O
biochar NOUN O
enriched VERB O
with ADP O
PSB PROPN B-AC
. PUNCT O
Its PRON O
potential ADJ O
use NOUN O
was AUX O
evaluated VERB O
as ADP O
a DET O
biofertilizer NOUN O
in ADP O
Allium PROPN O
cepa PROPN O
at ADP O
seedbed NOUN O
scale NOUN O
. PUNCT O

To PART O
quantify VERB O
how SCONJ O
predictive ADJ O
variations NOUN O
in ADP O
the DET O
genomic ADJ O
states NOUN O
are AUX O
of ADP O
differential ADJ O
gene NOUN O
expression NOUN O
at ADP O
the DET O
transcriptomic ADJ O
level NOUN O
, PUNCT O
we PRON O
compare VERB O
Gene PROPN B-LF
Ontology PROPN I-LF
( PUNCT O
GO PROPN B-AC
) PUNCT O
[ X O
62,63 NUM O
] X O
terms NOUN O
associated VERB O
with ADP O
high ADJ O
consequence NOUN O
genetic ADJ O
sequence NOUN O
variants NOUN O
( PUNCT O
“ PUNCT O
low ADJ O
, PUNCT O
” PUNCT O
“ PUNCT O
moderate ADJ O
, PUNCT O
” PUNCT O
and CCONJ O
“ PUNCT O
high ADJ O
” PUNCT O
IMPACT NOUN O
scores NOUN O
) PUNCT O
and CCONJ O
GO PROPN B-AC
terms NOUN O
associated VERB O
with ADP O
significantly ADV O
differentially ADV B-LF
expressed VERB I-LF
genes NOUN I-LF
( PUNCT O
DEGs PROPN B-AC
; PUNCT O
adjusted VERB O
p NOUN O
< ADP O
0.05 NUM O
) PUNCT O
. PUNCT O

According VERB O
to PART O
the DET O
diagnosis NOUN B-LF
and CCONJ I-LF
disease NOUN I-LF
characteristics NOUN I-LF
for ADP I-LF
multiple ADJ I-LF
sclerosis NOUN I-LF
common ADJ I-LF
data NOUN I-LF
elements NOUN I-LF
from ADP I-LF
the DET I-LF
National PROPN I-LF
Institute PROPN I-LF
of ADP I-LF
Neurological PROPN I-LF
Disorders PROPN I-LF
and CCONJ I-LF
Stroke PROPN I-LF
( PUNCT O
MS PROPN B-AC
CDEs NOUN B-AC
) PUNCT O
catalog NOUN O
, PUNCT O
more ADJ O
than ADP O
1600 NUM O
distinct ADJ O
CDEs NOUN B-AC
have AUX O
been AUX O
developed VERB O
to PART O
document VERB O
MS PROPN B-AC
in ADP O
clinical ADJ O
trials NOUN O
funded VERB O
by ADP O
NINDS PROPN B-AC
, PUNCT O
of ADP O
which PRON O
about ADV O
20 NUM O
items NOUN O
are AUX O
declared VERB O
as ADP O
core NOUN O
or CCONJ O
highly ADV O
recommended VERB O
, PUNCT O
depending VERB O
on ADP O
the DET O
study NOUN O
type NOUN O
[ PUNCT O
55 NUM O
] PUNCT O
. PUNCT O

Given VERB O
that SCONJ O
drug NOUN B-LF
- PUNCT I-LF
resistant ADJ I-LF
TB PROPN I-LF
( PUNCT O
DR PROPN B-AC
- PUNCT B-AC
TB PROPN B-AC
) PUNCT O
is AUX O
a DET O
key ADJ O
driving VERB O
factor NOUN O
behind ADP O
TB PROPN B-AC
mortality NOUN O
globally ADV O
, PUNCT O
implementation NOUN O
of ADP O
comprehensive ADJ O
, PUNCT O
rapid ADJ O
drug NOUN B-LF
susceptibility NOUN I-LF
testing NOUN I-LF
( PUNCT O
DST NOUN B-AC
) PUNCT O
is AUX O
critical ADJ O
in ADP O
all DET O
settings NOUN O
. PUNCT O

As ADV O
many ADJ O
as ADP O
half NOUN O
of ADP O
cirrhotic ADJ O
patients NOUN O
showed VERB O
signs NOUN O
of ADP O
diastolic ADJ O
dysfunction NOUN O
within ADP O
the DET O
first ADJ O
week NOUN O
after ADP O
liver NOUN B-LF
transplantation NOUN I-LF
( PUNCT O
LT NOUN B-AC
) PUNCT O
[ X O
6,7 NUM O
] PUNCT O
. PUNCT O

Basic ADJ B-LF
Local PROPN I-LF
Alignment PROPN I-LF
Search PROPN I-LF
Tool PROPN I-LF
( PUNCT O
Blast PROPN B-AC
, PUNCT O
Blastp PROPN O
[ PUNCT O
41 NUM O
] PUNCT O
) PUNCT O
was AUX O
employed VERB O
to PART O
detect VERB O
the DET O
sequences NOUN O
that PRON O
were AUX O
mapped VERB O
against ADP O
the DET O
non ADJ O
- ADJ O
redundant ADJ O
NCBI PROPN B-AC
protein NOUN O
database NOUN O
for ADP O
the DET O
best ADJ O
Blast PROPN B-AC
hits NOUN O
. PUNCT O

These DET O
events NOUN O
are AUX O
reminiscent ADJ O
of ADP O
the DET O
Salmonella PROPN O
system NOUN O
in ADP O
which PRON O
at ADP O
high ADJ O
multiplicity NOUN B-LF
of ADP I-LF
infection NOUN I-LF
( PUNCT O
MOI PROPN B-AC
) PUNCT O
, PUNCT O
there PRON O
is AUX O
residual ADJ O
IL-1β NOUN B-AC
secretion NOUN O
that PRON O
is AUX O
induced VERB O
independently ADV O
of ADP O
cytosolic ADJ O
flagellin NOUN O
and CCONJ O
, PUNCT O
presumably ADV O
, PUNCT O
of ADP O
Ipaf PROPN O
[ PUNCT O
12 NUM O
] PUNCT O
. PUNCT O

In ADP O
contrast NOUN O
to ADP O
colon NOUN O
cancer NOUN O
, PUNCT O
current ADJ O
guidelines NOUN O
recommend VERB O
preoperative ADJ B-LF
chemo NOUN I-LF
- PUNCT I-LF
radiotherapy NOUN I-LF
( PUNCT O
preCRT PROPN B-AC
) PUNCT O
for ADP O
patients NOUN O
with ADP O
advanced ADJ O
rectal ADJ O
cancer.[3 NOUN O
, PUNCT O
5 NUM O
] PUNCT O
Previous ADJ O
studies NOUN O
evaluating VERB O
the DET O
optimal ADJ O
timing NOUN O
of ADP O
AC PROPN B-AC
specifically ADV O
in ADP O
rectal ADJ O
cancer NOUN O
suggested VERB O
a DET O
period NOUN O
of ADP O
8 NUM O
weeks NOUN O
after ADP O
surgery NOUN O
, PUNCT O
similar ADJ O
to ADP O
colon NOUN O
cancer NOUN O
; PUNCT O
however ADV O
, PUNCT O
preCRT PROPN B-AC
was AUX O
not PART O
considered.[28 NUM O
, PUNCT O
29 NUM O
] PUNCT O
Currently ADV O
, PUNCT O
there PRON O
is VERB O
insufficient ADJ O
evidence NOUN O
to ADP O
support VERB O
to ADP O
AC PROPN B-AC
initiation NOUN O
within ADP O
8 NUM O
weeks NOUN O
after ADP O
surgery NOUN O
for ADP O
patients NOUN O
who PRON O
received VERB O
preCRT PROPN B-AC
. PUNCT O

BMI PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
MR PROPN B-AC
, PUNCT O
mendelian ADJ B-LF
randomisation NOUN I-LF
. PUNCT O

In ADP O
literature NOUN O
, PUNCT O
presentation NOUN O
and CCONJ O
outcome NOUN O
of ADP O
PCP PROPN B-AC
differs VERB O
between ADP O
patients NOUN O
with ADP O
human ADJ B-LF
immunodeficiency NOUN I-LF
virus NOUN I-LF
( PUNCT O
HIV PROPN B-AC
) PUNCT O
infection NOUN O
and CCONJ O
renal ADJ B-LF
transplant NOUN I-LF
recipients NOUN I-LF
( PUNCT O
RTRs NOUN B-AC
) PUNCT O
. PUNCT O

Lovastatin NOUN O
, PUNCT O
fluvastatin NOUN O
sodium NOUN O
, PUNCT O
simvastatin NOUN O
, PUNCT O
atorvastatin NOUN O
, PUNCT O
CoQ10 PROPN B-AC
, PUNCT O
and CCONJ O
mevalonic ADJ O
acid NOUN O
( PUNCT O
MVA PROPN B-AC
) PUNCT O
were AUX O
purchased VERB O
from ADP O
Cayman PROPN O
Chemical PROPN O
( PUNCT O
Ann PROPN O
Arbor PROPN O
, PUNCT O
MI PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
. PUNCT O
2 NUM O
- PUNCT O
Deoxy NOUN O
- PUNCT O
D NOUN O
- PUNCT O
glucose NOUN O
( PUNCT O
2 NUM O
- PUNCT O
DG PROPN O
) PUNCT O
, PUNCT O
carbonyl NOUN B-LF
cyanide NOUN I-LF
4-(trifluoromethoxy NOUN I-LF
) PUNCT I-LF
phenylhydrazone NOUN I-LF
( PUNCT O
FCCP PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
oligomycin NOUN O
A PROPN O
were AUX O
purchased VERB O
from ADP O
MedChem PROPN O
Express PROPN O
( PUNCT O
Monmouth PROPN O
Junction PROPN O
, PUNCT O
NJ PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
. PUNCT O
Cholesterol NOUN O
- PUNCT O
Water PROPN O
Soluble PROPN O
, PUNCT O
FPP PROPN B-AC
, PUNCT O
geranylgeranyl NOUN B-LF
pyrophosphate NOUN I-LF
( PUNCT O
GGPP PROPN B-AC
) PUNCT O
, PUNCT O
trichloroacetic NOUN B-LF
acid NOUN I-LF
( PUNCT O
TCA PROPN B-AC
) PUNCT O
, PUNCT O
CHX PROPN B-AC
, PUNCT O
MG132 PROPN O
, PUNCT O
DNase NOUN O
- PUNCT O
free ADJ O
RNase PROPN O
A PROPN O
, PUNCT O
triton NOUN O
X-100 PROPN O
, PUNCT O
crystal NOUN O
violet NOUN O
, PUNCT O
and CCONJ O
sulforhodamine NOUN B-LF
B PROPN I-LF
( PUNCT O
SRB PROPN B-AC
) PUNCT O
were AUX O
obtained VERB O
from ADP O
Sigma PROPN O
Aldrich PROPN O
( PUNCT O
St. PROPN O
Louis PROPN O
, PUNCT O
MO PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
. PUNCT O
Antibody NOUN O
sources NOUN O
were AUX O
as SCONJ O
follows VERB O
: PUNCT O
HMGCR PROPN B-AC
( PUNCT O
BD PROPN O
Biosciences PROPN O
, PUNCT O
San PROPN O
Jose PROPN O
, PUNCT O
CA PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
; PUNCT O
PKM2 PROPN B-AC
( PUNCT O
Cell PROPN O
Signaling PROPN O
, PUNCT O
Danvers PROPN O
, PUNCT O
MA PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
; PUNCT O
Hsp90 PROPN O
( PUNCT O
Abcam PROPN O
, PUNCT O
Cambridge PROPN O
, PUNCT O
Cambridgeshire PROPN O
, PUNCT O
UK PROPN O
) PUNCT O
, PUNCT O
β NOUN O
- PUNCT O
actin NOUN O
( PUNCT O
Sigma PROPN O
- PUNCT O
Aldrich PROPN O
, PUNCT O
St. PROPN O
Louis PROPN O
, PUNCT O
MO PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
; PUNCT O
horseradish NOUN O
peroxidase NOUN O
- PUNCT O
conjugated VERB O
secondary ADJ O
antibodies NOUN O
( PUNCT O
Jackson PROPN O
Laboratory PROPN O
, PUNCT O
Bar PROPN O
Harbor PROPN O
, PUNCT O
ME PROPN O
, PUNCT O
USA PROPN O
) PUNCT O
. PUNCT O

ACE PROPN B-AC
, PUNCT O
adverse ADJ B-LF
childhood NOUN I-LF
experience NOUN I-LF
; PUNCT O
GCSE PROPN B-AC
, PUNCT O
General PROPN B-LF
Certificate PROPN I-LF
of ADP I-LF
Secondary PROPN I-LF
Education PROPN I-LF
. PUNCT O

The DET O
Joint PROPN B-LF
United PROPN I-LF
Nations PROPN I-LF
Programme PROPN I-LF
on ADP I-LF
HIV PROPN I-LF
and CCONJ I-LF
AIDS PROPN I-LF
( PUNCT O
UNAIDS PROPN B-AC
) PUNCT O
90 NUM O
- SYM O
90 NUM O
- SYM O
90 NUM O
targets NOUN O
have AUX O
reinforced VERB O
the DET O
importance NOUN O
of ADP O
functioning VERB O
laboratory NOUN O
services NOUN O
to PART O
ensure VERB O
prompt ADJ O
diagnosis NOUN O
and CCONJ O
to PART O
assess VERB O
treatment NOUN O
efficacy NOUN O
. PUNCT O

MS PROPN B-AC
, PUNCT O
mass NOUN B-LF
spectrometry NOUN I-LF
; PUNCT O
M1 PROPN B-AC
, PUNCT O
matrix NOUN B-LF
protein NOUN I-LF
1 NUM I-LF
; PUNCT O
Udorn PROPN B-AC
, PUNCT O
A PROPN B-LF
/ SYM I-LF
Udorn/1972(H3N2 NOUN I-LF
) PUNCT I-LF
filamentous ADJ I-LF
virus NOUN I-LF

Interrupted ADJ O
time NOUN O
series NOUN O
analysis NOUN O
showed VERB O
that SCONJ O
increases NOUN O
in ADP O
store NOUN O
- PUNCT O
level NOUN O
sales NOUN O
of ADP O
fruits NOUN O
and CCONJ O
vegetables NOUN O
were AUX O
greater ADJ O
in ADP O
intervention NOUN O
stores NOUN O
than SCONJ O
predicted VERB O
at ADP O
3 NUM O
( PUNCT O
1.71 NUM O
standard ADJ B-LF
deviations NOUN I-LF
( PUNCT O
SDs NOUN B-AC
) PUNCT O
( PUNCT O
95 NUM O
% NOUN O
CI NOUN O
0.45 NUM O
, PUNCT O
2.96 NUM O
) PUNCT O
, PUNCT O
P NOUN O
= SYM O
0.01 NUM O
) PUNCT O
and CCONJ O
6 NUM O
months NOUN O
follow NOUN O
- PUNCT O
up NOUN O
( PUNCT O
2.42 NUM O
SDs NOUN B-AC
( PUNCT O
0.22 NUM O
, PUNCT O
4.62 NUM O
) PUNCT O
, PUNCT O
P NOUN O
= SYM O
0.03 NUM O
) PUNCT O
, PUNCT O
equivalent ADJ O
to ADP O
approximately ADV O
6,170 NUM O
and CCONJ O
approximately ADV O
9,820 NUM O
extra ADJ O
portions NOUN O
per ADP O
store NOUN O
, PUNCT O
per ADP O
week NOUN O
, PUNCT O
respectively ADV O
. PUNCT O

Urine ADJ O
samples NOUN O
were AUX O
centrifuged VERB O
at ADP O
3000x NUM O
g NOUN O
for ADP O
10 NUM O
min NOUN O
and CCONJ O
kept VERB O
at ADP O
-70 NUM O
° NOUN O
C NOUN O
until SCONJ O
used VERB O
. PUNCT O
uNGAL NOUN B-AC
and CCONJ O
urinary ADJ O
IL-18 NOUN B-AC
, PUNCT O
IL-6 NOUN B-AC
and CCONJ O
tumour NOUN B-LF
necrosis NOUN I-LF
factor NOUN I-LF
α NOUN I-LF
( PUNCT O
TNF NOUN B-AC
- PUNCT B-AC
α NOUN B-AC
) PUNCT O
were AUX O
measured VERB O
by ADP O
enzyme NOUN O
- PUNCT O
linked VERB O
immunosorbent ADJ O
assay NOUN O
kits NOUN O
( PUNCT O
Raybiotech PROPN O
, PUNCT O
Norcross PROPN O
, PUNCT O
GA PROPN O
, PUNCT O
USA PROPN O
for ADP O
urinary ADJ O
IL-18 NOUN B-AC
and CCONJ O
R&D PROPN O
Systems PROPN O
, PUNCT O
Minneapolis PROPN O
, PUNCT O
MN PROPN O
, PUNCT O
USA PROPN O
for ADP O
the DET O
others NOUN O
) PUNCT O
. PUNCT O

CS NOUN B-AC
, PUNCT O
complex ADJ B-LF
spike NOUN I-LF
. PUNCT O

p.4 X O
- X O
5 X O
: PUNCT O
In ADP O
terms NOUN O
of ADP O
a DET O
lack NOUN O
of ADP O
evidence NOUN O
about ADP O
integrated VERB O
representations NOUN O
for ADP O
verbal ADJ O
and CCONJ O
visual ADJ O
forms NOUN O
of ADP O
people NOUN O
: PUNCT O
( PUNCT O
a DET O
) PUNCT O
if SCONJ O
we PRON O
assume VERB O
that PRON O
this DET O
is AUX O
part NOUN O
of ADP O
general ADJ O
semantics NOUN O
then ADV O
there PRON O
is AUX O
converging VERB O
evidence NOUN O
for ADP O
multimodal ADJ O
semantic ADJ O
representations NOUN O
in ADP O
semantic ADJ B-LF
dementia NOUN I-LF
, PUNCT O
fMRI NOUN B-AC
, PUNCT O
TMS PROPN B-AC
, PUNCT O
computational ADJ O
models NOUN O
, PUNCT O
etc X O
. PUNCT O
( PUNCT O
for ADP O
an DET O
overview NOUN O
, PUNCT O
see VERB O
Lambon PROPN O
Ralph PROPN O
et X O
al NOUN O
NRN PROPN O
2017 NUM O
) PUNCT O
– PUNCT O
with ADP O
, PUNCT O
for ADP O
example NOUN O
, PUNCT O
Visser PROPN O
et X O
al NOUN O
( PUNCT O
2011 NUM O
) PUNCT O
showing VERB O
that PRON O
the DET O
same ADJ O
vATL NOUN O
region NOUN O
as SCONJ O
observed VERB O
in ADP O
the DET O
SEEG PROPN B-AC
in ADP O
this DET O
study NOUN O
is AUX O
activated VERB O
by ADP O
pictures NOUN O
, PUNCT O
sounds NOUN O
and CCONJ O
spokjen NOUN O
names NOUN O
; PUNCT O
( PUNCT O
b X O
) PUNCT O
SD PROPN B-AC
patients NOUN O
show VERB O
especially ADV O
poor ADJ O
performance NOUN O
for ADP O
semantic ADJ O
knowledge NOUN O
probed VERB O
at ADV O
the DET O
specific ADJ O
level NOUN O
including VERB O
people NOUN O
and CCONJ O
show VERB O
strong ADJ O
item NOUN O
associations NOUN O
when SCONJ O
knowledge NOUN O
for ADP O
a DET O
concept NOUN O
is AUX O
probed VERB O
using VERB O
words NOUN O
or CCONJ O
pictures NOUN O
( PUNCT O
indicating VERB O
degradation NOUN O
of ADP O
a DET O
shared VERB O
representation NOUN O
) PUNCT O
; PUNCT O
( PUNCT O
c X O
) PUNCT O
at ADV O
least ADV O
one NUM O
fMRI NOUN B-AC
study NOUN O
has AUX O
probed VERB O
people NOUN O
knowledge NOUN O
with ADP O
pictures NOUN O
and CCONJ O
words NOUN O
( PUNCT O
Rice PROPN O
et X O
al NOUN O
2017 NUM O
Proc PROPN O
Roy PROPN O
Soc PROPN O
) PUNCT O
which PRON O
found VERB O
bilateral ADJ O
vATL NOUN O
regions NOUN O
that PRON O
responded VERB O
to ADP O
both CCONJ O
the DET O
spoken VERB O
names NOUN O
and CCONJ O
pictures NOUN O
of ADP O
familiar ADJ O
people NOUN O
, PUNCT O
landmarks NOUN O
and CCONJ O
animals NOUN O
. PUNCT O

The DET O
split ADJ B-LF
luciferase NOUN I-LF
complementation NOUN I-LF
( PUNCT O
SLC PROPN B-AC
) PUNCT O
data NOUN O
analysis NOUN O
is AUX O
described VERB O
in ADP O
the DET O
Supporting VERB O
information NOUN O
( PUNCT O
S1 PROPN O
Materials NOUN O
and CCONJ O
Methods NOUN O
) PUNCT O
. PUNCT O

DENV PROPN B-AC
, PUNCT O
dengue PROPN B-LF
virus NOUN I-LF
; PUNCT O
GAPDH PROPN B-AC
, PUNCT O
glyceraldehyde NOUN B-LF
3 NUM I-LF
- PUNCT I-LF
phosphate NOUN I-LF
dehydrogenase NOUN I-LF
; PUNCT O
HeLa PROPN B-AC
, PUNCT O
human ADJ B-LF
epithelial NOUN I-LF
- PUNCT I-LF
derived VERB I-LF
cell NOUN I-LF
line NOUN I-LF
; PUNCT O
hpi PROPN B-AC
, PUNCT O
hours NOUN B-LF
post NOUN I-LF
infection NOUN I-LF
; PUNCT O
MOI PROPN B-AC
, PUNCT O
multiplicity NOUN B-LF
of ADP I-LF
infection NOUN I-LF
; PUNCT O
PFU PROPN B-AC
, PUNCT O
plaque NOUN B-LF
- PUNCT I-LF
forming VERB I-LF
units NOUN I-LF
; PUNCT O
PV PROPN B-AC
, PUNCT O
poliovirus NOUN B-LF
; PUNCT O
RT NOUN B-AC
- PUNCT B-AC
qPCR PROPN B-AC
, PUNCT O
reverse ADJ B-LF
transcription NOUN I-LF
quantitative ADJ I-LF
PCR NOUN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
; PUNCT O
ZIKV PROPN B-AC
, PUNCT O
Zika PROPN B-LF
virus NOUN I-LF
. PUNCT O

Intervention NOUN O
abbreviations NOUN O
: PUNCT O
LKM PROPN O
, PUNCT O
Loving PROPN O
– PUNCT O
Kindness PROPN O
Meditation PROPN O
; PUNCT O
MAPs PROPN O
; PUNCT O
Mindful PROPN O
Awareness PROPN O
Practices PROPN O
; PUNCT O
MBAP PROPN O
, PUNCT O
Mindfulness PROPN O
– PUNCT O
Based PROPN O
Art PROPN O
Processing PROPN O
; PUNCT O
MBCT PROPN O
, PUNCT O
Mindfulness PROPN O
– PUNCT O
Based PROPN O
Cognitive PROPN O
Therapy PROPN O
; PUNCT O
MBSR PROPN B-AC
, PUNCT O
Mindfulness PROPN B-LF
– PUNCT I-LF
Based PROPN I-LF
Stress PROPN I-LF
Reduction PROPN I-LF
; PUNCT O
MiCBT PROPN O
, PUNCT O
Mindfulness PROPN O
– PUNCT O
Integrated PROPN O
Cognitive PROPN O
Behaviour PROPN O
Therapy PROPN O
. PUNCT O

Based VERB O
on ADP O
criteria NOUN O
established VERB O
by ADP O
Oken PROPN O
et PROPN O
al NOUN O
. PUNCT O
[ PUNCT O
23 NUM O
] PUNCT O
, PUNCT O
we PRON O
defined VERB O
SGA PROPN B-AC
, PUNCT O
LGA PROPN B-AC
, PUNCT O
and CCONJ O
appropriate ADJ B-LF
for ADP I-LF
gestational ADJ I-LF
age NOUN I-LF
( PUNCT O
AGA NOUN B-AC
) PUNCT O
by ADP O
birth NOUN O
weight NOUN O
percentiles NOUN O
for ADP O
gestational ADJ O
age NOUN O
of ADP O
≤10th ADJ O
, PUNCT O
≥90th ADJ O
, PUNCT O
and CCONJ O
> NUM O
10th ADJ O
to PART O
< ADJ O
90th ADJ O
, PUNCT O
respectively ADV O
. PUNCT O

We PRON O
identify VERB O
approximately ADV O
230 NUM O
chromosomal ADJ O
clusters NOUN O
of ADP O
candidate NOUN O
antagonistic ADJ O
single ADJ B-LF
nucleotide NOUN I-LF
polymorphisms NOUN I-LF
( PUNCT O
SNPs PROPN B-AC
) PUNCT O
. PUNCT O

KEAP1 PROPN B-AC
is AUX O
located VERB O
at ADP O
19p13.2 NUM O
and CCONJ O
has VERB O
three NUM O
major ADJ O
domains NOUN O
: PUNCT O
an DET O
N NOUN O
- ADJ O
terminal ADJ O
broad ADJ B-LF
complex NOUN I-LF
, PUNCT I-LF
tramtrack NOUN I-LF
, PUNCT I-LF
and CCONJ I-LF
bric NOUN I-LF
- ADJ I-LF
a DET I-LF
- ADJ I-LF
brac NOUN I-LF
( PUNCT O
BTB PROPN B-AC
) PUNCT O
domain NOUN O
; PUNCT O
a DET O
central ADJ O
intervening VERB B-LF
region NOUN I-LF
( PUNCT O
IVR PROPN B-AC
) PUNCT O
; PUNCT O
and CCONJ O
a DET O
series NOUN O
of ADP O
six NUM O
C NOUN O
- ADJ O
terminal ADJ O
Kelch PROPN O
repeats NOUN O
[ X O
21 NUM O
] X O
( PUNCT O
Figure PROPN O
1 NUM O
) PUNCT O
. PUNCT O

We PRON O
therefore ADV O
undertook VERB O
a DET O
second ADJ O
cycle NOUN O
of ADP O
SAXS PROPN B-AC
modeling NOUN O
by ADP O
incorporating VERB O
the DET O
structural ADJ O
data NOUN O
deduced VERB O
from ADP O
HDX NOUN B-AC
- PUNCT B-AC
MS NOUN B-AC
and CCONJ O
far ADJ B-LF
- PUNCT I-LF
ultraviolet ADJ I-LF
( PUNCT O
far ADJ B-AC
- PUNCT B-AC
UV NOUN B-AC
) PUNCT O
SR NOUN B-AC
- PUNCT B-AC
CD NOUN B-AC
data NOUN O
. PUNCT O

AMsh PROPN B-AC
, PUNCT O
amphid NOUN B-LF
sheath NOUN I-LF
; PUNCT O
D1 NOUN B-AC
, PUNCT O
day NOUN B-LF
1 NUM I-LF
; PUNCT O
D2 NOUN B-AC
, PUNCT O
day NOUN B-LF
2 NUM I-LF
; PUNCT O
LRO NOUN B-AC
, PUNCT O
lysosome NOUN B-LF
- PUNCT I-LF
related VERB I-LF
organelle NOUN I-LF
; PUNCT O
RNAi NOUN B-AC
, PUNCT O
RNA NOUN B-LF
interference NOUN I-LF
; PUNCT O
SD NOUN O
, PUNCT O
standard ADJ O
deviation NOUN O
; PUNCT O
TEM PROPN B-AC
, PUNCT O
transmission NOUN B-LF
electron NOUN I-LF
microscopy NOUN I-LF
; PUNCT O
WT PROPN O
, PUNCT O
wild ADJ O
- PUNCT O
type NOUN O
. PUNCT O

A. X O
Selected VERB O
fatty ADJ O
acid NOUN O
composition NOUN O
of ADP O
epididymal ADJ B-LF
white ADJ I-LF
adipose ADJ I-LF
tissue NOUN I-LF
( PUNCT O
EWAT PROPN B-AC
, PUNCT O
left ADV O
) PUNCT O
or CCONJ O
inguinal ADJ B-LF
white ADJ I-LF
adipose ADJ I-LF
tissue NOUN I-LF
( PUNCT O
IWAT PROPN B-AC
, PUNCT O
right ADV O
) PUNCT O
from ADP O
mice NOUN O
fed VERB O
the DET O
indicated VERB O
diets NOUN O
. PUNCT O

SD PROPN O
: PUNCT O
standard ADJ O
deviation NOUN O
, PUNCT O
OHGA PROPN B-AC
: PUNCT O
oral ADJ B-LF
hypoglycemic ADJ I-LF
agents NOUN I-LF
, PUNCT O
ARBs PROPN O
: PUNCT O
Angiotension NOUN O
II NUM O
receptor NOUN O
blockers NOUN O

sway NOUN B-LF
path NOUN I-LF
length NOUN I-LF
of ADP I-LF
COP PROPN I-LF
( PUNCT O
SP PROPN B-AC
) PUNCT O
[ X O
mm]–defines VERB O
the DET O
total ADJ O
length NOUN O
of ADP O
path NOUN O
marked VERB O
by ADP O
the DET O
COP PROPN B-AC
; PUNCT O
the DET O
sum NOUN O
of ADP O
distances NOUN O
between ADP O
the DET O
locations NOUN O
of ADP O
the DET O
COP PROPN B-AC
constitutes VERB O
the DET O
path NOUN O
length NOUN O
; PUNCT O

Consistent ADJ O
with ADP O
Dunn PROPN O
and CCONJ O
colleagues NOUN O
[ PUNCT O
64 NUM O
] PUNCT O
, PUNCT O
the DET O
phase NOUN O
of ADP O
mapped VERB O
RPF NOUN B-AC
reads NOUN O
along ADP O
CDS PROPN B-AC
was AUX O
compromised VERB O
, PUNCT O
owing VERB O
to ADP O
the DET O
cutting VERB O
bias NOUN O
of ADP O
micrococcal NOUN B-LF
nuclease NOUN I-LF
( PUNCT O
MNase NOUN B-AC
) PUNCT O
( PUNCT O
S4 PROPN O
Fig PROPN O
and CCONJ O
S5 PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

MC PROPN B-AC
, PUNCT O
matching VERB B-LF
competition NOUN I-LF
. PUNCT O

The DET O
average NOUN O
of ADP O
three NUM O
experiments NOUN O
is AUX O
shown VERB O
( PUNCT O
± PUNCT O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean NOUN I-LF
[ X O
SEM X B-AC
] PUNCT O
) PUNCT O
. PUNCT O

These DET O
participants NOUN O
provided VERB O
additional ADJ O
informed ADJ O
consent NOUN O
during ADP O
screening NOUN O
and CCONJ O
received VERB O
HD NOUN B-AC
- PUNCT B-AC
MAPs NOUN B-AC
delivering VERB O
15 NUM O
μg NOUN O
( PUNCT O
MAP NOUN B-AC
- PUNCT O
FA-15 NOUN B-AC
- PUNCT O
bio NOUN O
) PUNCT O
or CCONJ O
uncoated VERB O
HD NOUN B-AC
- PUNCT B-AC
MAPs NOUN B-AC
( PUNCT O
MAP NOUN B-AC
- PUNCT O
FA-0 NOUN B-AC
- PUNCT O
bio NOUN O
) PUNCT O
applied VERB O
to ADP O
the DET O
forearm NOUN B-LF
. PUNCT O

Such DET O
an DET O
effect NOUN O
diverges VERB O
from ADP O
the DET O
empirical ADJ O
fMRI NOUN B-AC
variability NOUN O
time NOUN O
series NOUN O
, PUNCT O
which PRON O
is AUX O
not PART O
flat ADJ O
but CCONJ O
rather ADV O
follows VERB O
a DET O
trajectory NOUN O
similar ADJ O
to ADP O
the DET O
task NOUN O
- PUNCT O
related VERB O
response NOUN O
itself PRON O
( PUNCT O
Fig PROPN O
7B NUM O
) PUNCT O
. PUNCT O
However ADV O
, PUNCT O
changes NOUN O
in ADP O
both CCONJ O
amplitude NOUN O
and CCONJ O
temporal ADJ O
jitter NOUN O
can AUX O
yield VERB O
simulated VERB O
time NOUN O
- PUNCT O
point NOUN O
variability NOUN O
time NOUN O
series NOUN O
that PRON O
are AUX O
similar ADJ O
to ADP O
the DET O
fMRI NOUN B-AC
variability NOUN O
time NOUN O
series NOUN O
, PUNCT O
depending VERB O
on ADP O
the DET O
shape NOUN O
of ADP O
the DET O
simulated VERB O
impulse NOUN B-LF
response NOUN I-LF
function NOUN I-LF
( PUNCT O
IRF PROPN B-AC
) PUNCT O
used VERB O
( PUNCT O
Fig PROPN O
6C NUM O
, PUNCT O
6D NUM O
, PUNCT O
6 NUM O
G NOUN O
and CCONJ O
6H NOUN O
) PUNCT O
. PUNCT O
Second ADJ O
, PUNCT O
the DET O
sources NOUN O
of ADP O
noise NOUN O
varied VERB O
in ADP O
how SCONJ O
they PRON O
affected VERB O
the DET O
mean ADJ O
amplitude NOUN O
of ADP O
the DET O
response NOUN O
. PUNCT O

GC NOUN B-AC
= PUNCT O
geriatric ADJ B-LF
comanagement NOUN I-LF

The DET O
tumor NOUN O
suppressor NOUN O
function NOUN O
of ADP O
the DET O
3 NUM O
- PUNCT O
phosphoinositide NOUN O
phosphatase NOUN O
PTEN PROPN O
[ PUNCT O
20,21 NUM O
] PUNCT O
, PUNCT O
the DET O
frequent ADJ O
somatic ADJ O
mutation NOUN O
of ADP O
phosphatidylinositol NOUN B-LF
( PUNCT O
PI PROPN B-AC
) PUNCT O
3 NUM O
- PUNCT O
kinase NOUN O
in ADP O
human ADJ O
cancers NOUN O
[ PUNCT O
23 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
the DET O
discovery NOUN O
of ADP O
a DET O
germline ADJ O
Akt2 PROPN O
loss NOUN O
- PUNCT O
of ADP O
- PUNCT O
function NOUN O
mutation NOUN O
in ADP O
a DET O
family NOUN O
with ADP O
autosomal ADJ O
dominant ADJ O
insulin NOUN O
- PUNCT O
resistant ADJ O
diabetes NOUN O
[ PUNCT O
58 NUM O
] PUNCT O
underscore VERB O
the DET O
central ADJ O
role NOUN O
of ADP O
this DET O
pathway NOUN O
in ADP O
human ADJ O
disease NOUN O
. PUNCT O

2,3,7,8 NUM O
- PUNCT O
tetrachlorodibenzo NOUN O
- PUNCT O
p NOUN O
, PUNCT O
p NOUN O
- PUNCT O
dioxin NOUN O
( PUNCT O
C12H4Cl4O2 PROPN O
; PUNCT O
p NOUN O
- PUNCT O
dioxin NOUN O
, PUNCT O
TCDD PROPN B-AC
) PUNCT O
has VERB O
a DET O
Log PROPN O
P NOUN O
of ADP O
5.42 NUM O
, PUNCT O
a DET O
vdWD NOUN B-AC
of ADP O
0.735 NUM O
nm NOUN O
and CCONJ O
a DET O
Log PROPN B-LF
P NOUN I-LF
/ SYM I-LF
vdWD NOUN I-LF
of ADP O
7.38 NUM O
nm-1 NUM O
( PUNCT O
Table PROPN O
4 NUM O
) PUNCT O
. PUNCT O
p NOUN O
- PUNCT O
dioxin NOUN O
has VERB O
a DET O
calc NOUN O
Lexternal PROPN O
structure NOUN O
/ SYM O
Hpolar NOUN O
group NOUN O
ratio NOUN O
of ADP O
11.86 NUM O
, PUNCT O
and CCONJ O
a DET O
nl NOUN O
calc NOUN O
Lexternal PROPN O
structure NOUN O
/ SYM O
Hpolar NOUN O
group NOUN O
quotient NOUN O
of ADP O
4.31 NUM O
. PUNCT O
8 NUM O
- PUNCT O
OH-2,3,7 NUM O
- PUNCT O
TriCDD NOUN O
has VERB O
a DET O
calc NOUN O
Lexternal PROPN O
structure NOUN O
/ SYM O
Hpolar NOUN O
group NOUN O
ratio NOUN O
of ADP O
5.25 NUM O
, PUNCT O
and CCONJ O
a DET O
nl NOUN O
calc NOUN O
Lexternal PROPN O
structure NOUN O
/ SYM O
Hpolar NOUN O
group NOUN O
quotient NOUN O
of ADP O
1.91 NUM O
8 NUM O
- PUNCT O
O NOUN O
- PUNCT O
glucoronide-2,3,7 NOUN O
- PUNCT O
TriCDD NOUN O
has VERB O
a DET O
calc NOUN O
Lexternal PROPN O
structure NOUN O
/ SYM O
Hpolar NOUN O
group NOUN O
ratio NOUN O
of ADP O
1.15 NUM O
, PUNCT O
and CCONJ O
a DET O
nl NOUN O
calc NOUN O
Lexternal PROPN O
structure NOUN O
/ SYM O
Hpolar NOUN O
group NOUN O
quotient NOUN O
of ADP O
0.419 NUM O
. PUNCT O

CFH PROPN O
mutations NOUN O
have AUX O
been AUX O
described VERB O
in ADP O
association NOUN O
with ADP O
atypical ADJ B-LF
haemolytic ADJ I-LF
uraemic ADJ I-LF
syndrome NOUN I-LF
( PUNCT O
aHUS PROPN B-AC
) PUNCT O
. PUNCT O
The DET O
majority NOUN O
of ADP O
the DET O
mutations NOUN O
are AUX O
missense ADJ O
changes NOUN O
that PRON O
cluster VERB O
in ADP O
the DET O
C PROPN O
- PUNCT O
terminal ADJ O
region NOUN O
and CCONJ O
impair VERB O
the DET O
ability NOUN O
of ADP O
factor NOUN O
H PROPN O
to PART O
regulate VERB O
surface NOUN O
- PUNCT O
bound VERB O
C3b NOUN O
. PUNCT O

PD-1 PROPN B-AC
, PUNCT O
Programmed ADJ B-LF
cell NOUN I-LF
death NOUN I-LF
protein NOUN I-LF
1 NUM I-LF
; PUNCT O
PD PROPN B-AC
- PUNCT B-AC
L1 PROPN B-AC
, PUNCT O
PD-1 PROPN B-LF
ligand NOUN I-LF
1 NUM O
; PUNCT O
RM PROPN O
, PUNCT O
repeated VERB O
measures NOUN O
; PUNCT O
TCR PROPN B-AC
, PUNCT O
T PROPN B-LF
cell NOUN I-LF
receptor NOUN I-LF
. PUNCT O

Four NUM O
different ADJ O
centrifugation NOUN B-LF
protocols NOUN I-LF
were AUX O
evaluated VERB O
using VERB O
urine NOUN O
samples NOUN O
with ADP O
preservative NOUN O
of ADP O
cancer NOUN O
patients NOUN O
and CCONJ O
HVs NOUN B-AC
. PUNCT O
A X O
: PUNCT O
Total ADJ O
DNA NOUN O
concentrations NOUN O
analyzed VERB O
with ADP O
Qubit PROPN O
fluorometer NOUN O
and CCONJ O
ddPCR NOUN B-AC
. PUNCT O
B NOUN O
: PUNCT O
Amount NOUN O
of ADP O
cfDNA NOUN B-AC
and CCONJ O
gDNA NOUN B-AC
determined VERB O
with ADP O
the DET O
FragmentAnalyzer PROPN O
. PUNCT O
cfDNA NOUN B-AC
= PUNCT O
circulating VERB B-LF
cell NOUN I-LF
- PUNCT I-LF
free ADJ I-LF
DNA NOUN I-LF
, PUNCT O
CP PROPN B-AC
I NOUN O
= PUNCT O
4,000 NUM O
g NOUN O
10min NUM O
, PUNCT O
CP PROPN B-AC
II PROPN O
= PUNCT O
3,000 NUM O
g NOUN O
15min NUM O
, PUNCT O
CP PROPN B-AC
III PROPN O
= PUNCT O
2,680 NUM O
g NOUN O
10min NUM O
, PUNCT O
CP PROPN B-AC
IV NOUN O
= PUNCT O
750 NUM O
g NOUN O
10min NUM O
, PUNCT O
ddPCR NOUN B-AC
= PUNCT O
digital ADJ B-LF
droplet NOUN I-LF
PCR NOUN I-LF
, PUNCT O
gDNA NOUN B-AC
= PUNCT O
genomic ADJ B-LF
DNA NOUN I-LF
, PUNCT O
HV NOUN B-AC
= PUNCT O
healthy ADJ B-LF
volunteer NOUN I-LF
. PUNCT O

Expected VERB O
genetic ADJ B-LF
advance NOUN I-LF
σ2p(GA)=K×σ2p×h2B NOUN B-AC

We PRON O
will AUX O
define VERB O
each PRON O
of ADP O
the DET O
performance NOUN O
measures NOUN O
in ADP O
turn NOUN O
, PUNCT O
after ADP O
first ADV O
defining VERB O
true ADJ B-LF
positives NOUN I-LF
( PUNCT O
TP NOUN B-AC
) PUNCT O
, PUNCT O
true ADJ B-LF
negatives NOUN I-LF
( PUNCT O
TN PROPN B-AC
) PUNCT O
, PUNCT O
false ADJ B-LF
positives NOUN I-LF
( PUNCT O
FP NOUN B-AC
) PUNCT O
and CCONJ O
false ADJ B-LF
negatives NOUN I-LF
( PUNCT O
FN NOUN B-AC
) PUNCT O
, PUNCT O
respectively ADV O
. PUNCT O

Addition NOUN O
of ADP O
antioxidative ADJ O
superoxide NOUN O
scavenger NOUN O
Tiron PROPN O
( PUNCT O
10 NUM O
mM NOUN O
) PUNCT O
decreased VERB O
H NOUN B-AC
/ SYM B-AC
R NOUN B-AC
- PUNCT O
induced VERB O
apoptosis NOUN O
of ADP O
control NOUN O
cells NOUN O
to ADP O
60 NUM O
% NOUN O
( PUNCT O
Fig PROPN O
1E NUM O
and CCONJ O
1F NOUN O
) PUNCT O
as ADP O
well ADV O
as ADP O
apoptosis NOUN O
of ADP O
mitoNEET NOUN O
- PUNCT O
KD NOUN B-AC
cells NOUN O
to ADP O
the DET O
same ADJ O
level NOUN O
indicating VERB O
that PRON O
mitoNEET NOUN O
- PUNCT O
counteracted VERB O
apoptosis NOUN O
was AUX O
caused VERB O
by ADP O
superoxide NOUN O
radicals NOUN O
and CCONJ O
was AUX O
consequently ADV O
related VERB O
to ADP O
reactive ADJ B-LF
oxygen NOUN I-LF
species NOUN I-LF
( PUNCT O
ROS PROPN B-AC
) PUNCT O
. PUNCT O
To PART O
assess VERB O
the DET O
role NOUN O
of ADP O
glutathione NOUN B-LF
redox NOUN O
system NOUN O
in ADP O
our PRON O
H NOUN B-AC
/ SYM B-AC
R NOUN B-AC
model NOUN O
, PUNCT O
we PRON O
used VERB O
glutathione NOUN B-LF
reduced VERB O
ethyl NOUN O
ester NOUN O
( PUNCT O
GSH PROPN B-AC
- PUNCT B-AC
MEE PROPN B-AC
) PUNCT O
( PUNCT O
Fig PROPN O
1E NUM O
and CCONJ O
1 NUM O
G NOUN O
) PUNCT O
, PUNCT O
an DET O
esterified VERB O
glutathione NOUN B-LF
compound NOUN O
that PRON O
is AUX O
readily ADV O
transported VERB O
into ADP O
the DET O
cell NOUN O
and CCONJ O
increases VERB O
intracellularly ADV O
the DET O
bioavailability NOUN O
of ADP O
glutathione NOUN B-LF
[ PUNCT O
27 NUM O
] PUNCT O
. PUNCT O

TB NOUN B-AC
, PUNCT O
tuberculosis NOUN B-LF
. PUNCT O

Among ADP O
patients NOUN O
aged VERB O
60 NUM O
to PART O
69 NUM O
in ADP O
G2 PROPN O
, PUNCT O
those PRON O
without ADP O
previous ADJ O
CVD NOUN B-AC
were AUX O
predicted VERB O
to PART O
live VERB O
a DET O
further ADJ O
22.1 NUM O
years NOUN O
( PUNCT O
16.1 NUM O
quality NOUN B-LF
- PUNCT I-LF
adjusted VERB I-LF
life NOUN I-LF
years NOUN I-LF
[ PUNCT O
QALYs NOUN B-AC
] PUNCT O
) PUNCT O
and CCONJ O
those PRON O
with ADP O
CVD NOUN B-AC
a DET O
further ADJ O
18.6 NUM O
years NOUN O
( PUNCT O
11.8 NUM O
QALYs NOUN B-AC
) PUNCT O
. PUNCT O

The DET O
routine ADJ O
clinical ADJ O
DTI NOUN O
was AUX O
a DET O
single ADJ O
- ADJ O
shot NOUN O
multi ADJ O
- ADJ O
level ADJ O
echo NOUN O
planar NOUN O
sequence NOUN O
with ADP O
40 NUM O
slices NOUN O
( PUNCT O
repetition NOUN B-LF
time NOUN I-LF
( PUNCT O
TR NOUN B-AC
) PUNCT O
8000 NUM O
msec NOUN O
, PUNCT O
echo NOUN B-LF
time NOUN I-LF
( PUNCT O
TE PROPN B-AC
) PUNCT O
88 NUM O
msec NOUN O
, PUNCT O
inversion NOUN O
Time NOUN O
( PUNCT O
IT PROPN O
): PUNCT O
-1 NUM O
msec NOUN O
, PUNCT O
field NOUN B-LF
of ADP I-LF
view NOUN I-LF
( PUNCT O
FOV PROPN B-AC
) PUNCT O
25 NUM O
x SYM O
30 NUM O
cm NOUN O
, PUNCT O
30 NUM O
gradient NOUN O
directions NOUN O
at ADP O
b NOUN O
values NOUN O
of ADP O
1000 NUM O
mm2 NOUN O
/ NOUN O
s NOUN O
, PUNCT O
5 NUM O
gradient NOUN O
directions NOUN O
at ADP O
b NOUN O
= SYM O
0 NUM O
mm2 NOUN O
/ NOUN O
s NOUN O
, PUNCT O
voxel NOUN O
sizes NOUN O
: PUNCT O
2.00 NUM O
, PUNCT O
2.00 NUM O
, PUNCT O
2.00 NUM O
) PUNCT O
. PUNCT O

The DET O
incidence NOUN O
density NOUN O
sampling NOUN O
design NOUN O
assures VERB O
equal ADJ O
time NOUN O
during ADP O
which PRON O
case NOUN O
and CCONJ O
control NOUN O
subjects NOUN O
are AUX O
at ADP O
risk NOUN O
for ADP O
the DET O
exposures NOUN O
of ADP O
interest NOUN O
and CCONJ O
generates VERB O
odds NOUN B-LF
ratios NOUN I-LF
( PUNCT O
ORs NOUN B-AC
) PUNCT O
interpretable ADJ O
as ADP O
unbiased ADJ O
estimates NOUN O
of ADP O
incidence NOUN O
rate NOUN O
ratios NOUN O
[ PUNCT O
21 NUM O
] PUNCT O
. PUNCT O

Wolfram PROPN B-LF
syndrome NOUN I-LF
( PUNCT O
WS PROPN B-AC
) PUNCT O
is AUX O
a DET O
genetic ADJ O
disorder NOUN O
characterized VERB O
by ADP O
diabetes NOUN O
insipidus NOUN O
, PUNCT O
diabetes NOUN O
mellitus NOUN O
, PUNCT O
optic ADJ O
atrophy NOUN O
, PUNCT O
deafness NOUN O
, PUNCT O
and CCONJ O
brain NOUN O
atrophy NOUN O
. PUNCT O

Blood NOUN O
spots NOUN O
were AUX O
obtained VERB O
at ADP O
screening NOUN O
and CCONJ O
stored VERB O
on ADP O
filter NOUN O
paper NOUN O
for ADP O
polymerase NOUN B-LF
chain NOUN I-LF
reaction NOUN I-LF
( PUNCT O
PCR PROPN B-AC
) PUNCT O
genotyping NOUN O
. PUNCT O

However ADV O
, PUNCT O
in ADP O
cases NOUN O
on ADP O
noncomplementers NOUN O
( PUNCT O
e.g. X O
, PUNCT O
Hs PROPN B-AC
- PUNCT O
CDC14A PROPN O
) PUNCT O
, PUNCT O
only ADV O
two NUM O
yeast NOUN O
spores NOUN O
( PUNCT O
carrying VERB O
the DET O
wild ADJ O
- PUNCT O
type NOUN O
yeast NOUN O
allele NOUN O
) PUNCT O
survive VERB O
on ADP O
YPD PROPN O
and CCONJ O
fail VERB O
to PART O
grow VERB O
on ADP O
YPD PROPN O
+ SYM O
G418 PROPN O
but CCONJ O
grow VERB O
on ADP O
5 NUM O
- PUNCT O
FOA PROPN O
, PUNCT O
indicating VERB O
plasmid NOUN O
loss NOUN O
. PUNCT O
( PUNCT O
C NOUN O
) PUNCT O
Each DET O
confirmed VERB O
humanized ADJ O
haploid ADJ O
yeast NOUN O
strain NOUN O
was AUX O
assayed VERB O
for ADP O
growth NOUN O
defects NOUN O
to PART O
quantify VERB O
the DET O
replaceability NOUN O
. PUNCT O
5 NUM O
- PUNCT O
FOA PROPN O
, PUNCT O
5 NUM O
- PUNCT O
flouroorotic ADJ O
acid NOUN O
; PUNCT O
CDC14A PROPN O
, PUNCT O
human ADJ O
dual ADJ O
specificity NOUN O
protein NOUN O
phosphatase NOUN O
CDC14A PROPN O
gene NOUN O
; PUNCT O
hetKO PROPN B-AC
, PUNCT O
heterozygous ADJ B-LF
diploid NOUN I-LF
knockout NOUN I-LF
, PUNCT O
Hs PROPN B-AC
, PUNCT O
H. PROPN O
sapiens ADJ O
; PUNCT O
SD PROPN O
, PUNCT O
synthetic ADJ O
defined VERB O
; PUNCT O
Ura PROPN O
, PUNCT O
uracil NOUN O
; PUNCT O
YIPF5 PROPN O
, PUNCT O
human ADJ O
YIPF5 PROPN O
gene NOUN O
; PUNCT O
YPD PROPN O
, PUNCT O
yeast NOUN O
extract NOUN O
peptone NOUN O
dextrose NOUN O
. PUNCT O

Despite SCONJ O
evidence NOUN O
of ADP O
ANC PROPN B-AC
attendance NOUN O
and CCONJ O
administration NOUN O
of ADP O
intermittent ADJ B-LF
preventive ADJ I-LF
treatment NOUN I-LF
with ADP I-LF
sulfadoxine NOUN I-LF
- PUNCT I-LF
pyrimethamine NOUN I-LF
( PUNCT O
IPTp PROPN B-AC
- PUNCT B-AC
SP PROPN B-AC
) PUNCT O
dosage NOUN O
during ADP O
these DET O
visits NOUN O
, PUNCT O
malaria NOUN O
positivity NOUN O
rate NOUN O
was AUX O
still ADV O
high ADJ O
among ADP O
pregnant ADJ O
women NOUN O
and CCONJ O
children NOUN O
below ADP O
five NUM O
years NOUN O
in ADP O
these DET O
two NUM O
rural ADJ O
counties NOUN O
. PUNCT O

The DET O
STOP PROPN O
TB PROPN B-AC
Partnership PROPN O
is AUX O
an DET O
international ADJ O
initiative NOUN O
involving VERB O
several ADJ O
agencies NOUN O
seeking VERB O
to PART O
combat VERB O
the DET O
rise NOUN O
of ADP O
tuberculosis NOUN B-LF

Thus ADV O
, PUNCT O
we PRON O
expressed VERB O
carnitine NOUN O
palmitoyltransferase NOUN O
1AM PROPN O
( PUNCT O
CPT1AM PROPN B-AC
) PUNCT O
, PUNCT O
a DET O
permanently ADV B-LF
active ADJ I-LF
mutant ADJ I-LF
form NOUN I-LF
of ADP I-LF
CPT1A PROPN I-LF
( PUNCT O
the DET O
rate NOUN O
- PUNCT O
limiting VERB O
enzyme NOUN O
in ADP O
FAO PROPN B-AC
) PUNCT O
, PUNCT O
in ADP O
a DET O
rat NOUN O
brown ADJ O
adipocyte NOUN O
( PUNCT O
rBA PROPN B-AC
) PUNCT O
cell NOUN O
line NOUN O
through ADP O
adenoviral ADJ O
infection NOUN O
. PUNCT O

AUD PROPN B-AC
, PUNCT O
Australian ADJ B-LF
dollar NOUN I-LF
; PUNCT O
IHD PROPN B-AC
, PUNCT O
ischemic ADJ B-LF
heart NOUN I-LF
disease NOUN I-LF
; PUNCT O
SEIFA PROPN B-AC
, PUNCT O
Socio ADJ B-LF
- PUNCT I-LF
Economic ADJ I-LF
Indexes NOUN I-LF
for ADP I-LF
Areas PROPN I-LF
. PUNCT O

We PRON O
chose VERB O
models NOUN O
with ADP O
small ADJ O
numbers NOUN O
of ADP O
features NOUN O
, PUNCT O
with ADP O
performance NOUN O
at ADP O
or CCONJ O
no DET O
more ADJ O
than ADP O
1 NUM O
standard ADJ O
error NOUN O
away ADV O
from ADP O
best ADJ O
test NOUN O
performance NOUN O
, PUNCT O
and CCONJ O
with ADP O
interpretable ADJ O
outcomes NOUN O
— PUNCT O
for ADP O
example NOUN O
, PUNCT O
scores NOUN O
generated VERB O
by ADP O
a DET O
boosted VERB O
decision NOUN O
tree NOUN O
or CCONJ O
logistic ADJ B-LF
regression NOUN I-LF
( PUNCT O
LR PROPN B-AC
) PUNCT O
approach NOUN O
. PUNCT O

Two NUM O
quantitative ADJ B-LF
PCR NOUN I-LF
( PUNCT O
qPCR NOUN B-AC
) PUNCT O
assays NOUN O
were AUX O
developed VERB O
for ADP O
ultra ADJ O
- PUNCT O
sensitive ADJ O
detection NOUN O
of ADP O
Plasmodium PROPN O
falciparum NOUN O
, PUNCT O
targeting VERB O
the DET O
high ADJ O
- PUNCT O
copy NOUN O
telomere NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
repetitive ADJ I-LF
element NOUN I-LF
2 NUM I-LF
( PUNCT O
TARE-2 PROPN B-AC
, PUNCT O
∼250 NUM O
copies NOUN O
/ SYM O
genome NOUN O
) PUNCT O
and CCONJ O
the DET O
var NOUN O
gene NOUN O
acidic ADJ O
terminal ADJ O
sequence NOUN O
( PUNCT O
varATS NOUN B-AC
, PUNCT O
59 NUM O
copies NOUN O
/ SYM O
genome NOUN O
) PUNCT O
. PUNCT O

NZ PROPN B-AC
cohort NOUN O
( PUNCT O
n NOUN O
= SYM O
376 NUM O
) PUNCT O
consisted VERB O
of ADP O
94 NUM O
% NOUN O
Caucasians PROPN O
while SCONJ O
the DET O
US PROPN B-AC
cohort NOUN O
consisted VERB O
of ADP O
African PROPN B-LF
Americans PROPN I-LF
( PUNCT O
AA PROPN B-AC
) PUNCT O
, PUNCT O
n NOUN O
= SYM O
202 NUM O
, PUNCT O
and CCONJ O
European PROPN B-LF
Americans PROPN I-LF
( PUNCT O
EA PROPN B-AC
) PUNCT O
, PUNCT O
n NOUN O
= SYM O
232 NUM O
. PUNCT O

Yet CCONJ O
, PUNCT O
beneath ADP O
all DET O
these DET O
data NOUN O
were AUX O
important ADJ O
limitations NOUN O
that PRON O
undermined VERB O
the DET O
evidence NOUN O
: PUNCT O
inevitable ADJ O
measurement NOUN O
errors NOUN O
due ADJ O
to PART O
dietary ADJ O
assessment NOUN O
via ADP O
subjective ADJ O
report NOUN O
, PUNCT O
differences NOUN O
in ADP O
exposure NOUN O
assessment NOUN O
window NOUN O
, PUNCT O
predominantly ADV O
white ADJ O
study NOUN O
populations NOUN O
, PUNCT O
and CCONJ O
inability NOUN O
to PART O
disentangle VERB O
potentially ADV O
distinct ADJ O
health NOUN O
effects NOUN O
of ADP O
individual ADJ O
PUFAs PROPN B-AC
. PUNCT O
Indeed ADV O
, PUNCT O
except SCONJ O
for ADP O
the DET O
essential ADJ O
fatty NOUN O
acids NOUN O
alpha NOUN B-LF
- PUNCT I-LF
linolenic ADJ I-LF
acid NOUN I-LF
( PUNCT O
ALA PROPN B-AC
) PUNCT O
and CCONJ O
LA PROPN B-AC
, PUNCT O
levels NOUN O
of ADP O
circulating VERB O
long ADJ O
- PUNCT O
chain NOUN O
PUFA PROPN B-AC
derivatives NOUN O
are AUX O
functions NOUN O
of ADP O
both CCONJ O
exogenous ADJ O
( PUNCT O
via ADP O
dietary ADJ O
intake NOUN O
) PUNCT O
and CCONJ O
endogenous ADJ O
( PUNCT O
via ADP O
lipogenesis NOUN O
) PUNCT O
origins NOUN O
, PUNCT O
with ADP O
unique ADJ O
biochemical ADJ O
properties NOUN O
and CCONJ O
metabolic ADJ O
effects NOUN O
[ PUNCT O
23 NUM O
] PUNCT O
. PUNCT O

* PUNCT O
CI NOUN B-AC
: PUNCT O
Confidence NOUN B-LF
interval NOUN I-LF

AtbR PROPN B-AC
clones NOUN B-AC
, PUNCT O
antibiotic ADJ B-LF
resistant ADJ I-LF
clones NOUN I-LF
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
proteins NOUN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

To PART O
more ADV O
fully ADV O
explore VERB O
biomarkers NOUN O
associated VERB O
with ADP O
HIV PROPN O
reactivation NOUN O
after ADP O
the DET O
interruption NOUN O
of ADP O
ART PROPN B-AC
, PUNCT O
we PRON O
also ADV O
accessed VERB O
peripheral ADJ B-LF
blood NOUN I-LF
mononuclear ADJ I-LF
cells NOUN I-LF
( PUNCT O
PBMCs PROPN B-AC
) PUNCT O
from ADP O
a DET O
previously ADV O
described VERB O
case NOUN O
of ADP O
an DET O
HIV PROPN O
- PUNCT O
infected VERB O
adult NOUN O
who PRON O
underwent VERB O
an DET O
allogenic ADJ O
hematopoietic ADJ O
stem NOUN O
- PUNCT O
cell NOUN O
transplantation NOUN O
( PUNCT O
HSCT PROPN B-AC
Participant PROPN O
B PROPN O
) PUNCT O
[ PUNCT O
16 NUM O
] PUNCT O
. PUNCT O

Considering VERB O
the DET O
fact NOUN O
that SCONJ O
nandrolone NOUN B-LF
decanoate NOUN I-LF
( PUNCT O
ND PROPN B-AC
) PUNCT O
is AUX O
one NUM O
of ADP O
the DET O
most ADV O
commonly ADV O
used VERB O
AAS PROPN B-AC
, PUNCT O
the DET O
aim NOUN O
of ADP O
this DET O
study NOUN O
was AUX O
to PART O
evaluate VERB O
the DET O
effects NOUN O
of ADP O
chronic ADJ O
ND PROPN B-AC
administration NOUN O
and CCONJ O
exercise NOUN O
( PUNCT O
swimming NOUN O
protocol NOUN O
) PUNCT O
on ADP O
behavioral ADJ O
changes NOUN O
in ADP O
rats NOUN O
by ADP O
means NOUN O
of ADP O
specific ADJ O
behavioral ADJ O
tests NOUN O
, PUNCT O
as ADP O
well ADV O
as ADP O
on ADP O
hippocampal ADJ O
PV NOUN B-AC
content NOUN O
. PUNCT O

Cdk PROPN B-AC
, PUNCT O
cyclin NOUN B-LF
- PUNCT I-LF
dependent ADJ I-LF
kinase NOUN I-LF
; PUNCT O
CycD PROPN B-AC
, PUNCT O
Cyclin NOUN B-LF
D PROPN I-LF
; PUNCT O
E2F NOUN B-AC
, PUNCT O
E2F NOUN B-LF
transcription NOUN I-LF
factor NOUN I-LF
; PUNCT O
FAIRE PROPN B-AC
, PUNCT O
formaldehyde NOUN B-LF
- PUNCT I-LF
assisted VERB I-LF
isolation NOUN I-LF
of ADP I-LF
regulatory ADJ I-LF
elements NOUN I-LF
; PUNCT O
FAIRE PROPN B-AC
- PUNCT B-AC
seq NOUN B-AC
, PUNCT O
FAIRE PROPN B-LF
sequencing NOUN I-LF
; PUNCT O
MA PROPN O
plot NOUN O
, PUNCT O
scatter NOUN O
plot NOUN O
onto ADP O
M NOUN O
( PUNCT O
log NOUN O
ratio NOUN O
) PUNCT O
and CCONJ O
A NOUN O
( PUNCT O
mean ADJ O
average NOUN O
) PUNCT O
scales NOUN O
; PUNCT O
RNA NOUN B-AC
- PUNCT B-AC
seq NOUN B-AC
, PUNCT O
RNA NOUN B-LF
sequencing NOUN I-LF
. PUNCT O

Circulating VERB O
levels NOUN O
of ADP O
platelet NOUN B-LF
factor NOUN I-LF
4 NUM I-LF
( PUNCT O
PF4 PROPN B-AC
) PUNCT O
were AUX O
substantially ADV O
elevated ADJ O
in ADP O
COVID-19 PROPN B-AC
patients NOUN O
when SCONJ O
compared VERB O
to ADP O
both CCONJ O
hospitalised ADJ O
( PUNCT O
HoC PROPN O
) PUNCT O
and CCONJ O
healthy ADJ O
controls NOUN O
( PUNCT O
HeC PROPN O
) PUNCT O
( PUNCT O
p NOUN O
= SYM O
0.012 NUM O
and CCONJ O
p NOUN O
= SYM O
0.0033 NUM O
, PUNCT O
respectively ADV O
; PUNCT O
Fig NOUN O
3A NUM O
) PUNCT O
. PUNCT O
Nonetheless ADV O
, PUNCT O
circulating VERB O
PF4 PROPN B-AC
levels NOUN O
could AUX O
not PART O
differentiate VERB O
between ADP O
severe ADJ O
and CCONJ O
nonsevere ADJ O
COVID-19 PROPN B-AC
patient NOUN O
cohorts NOUN O
( PUNCT O
p NOUN O
= SYM O
0.85 NUM O
) PUNCT O
. PUNCT O

ApoE NOUN O
= PUNCT O
apolipoprotein NOUN O
E NOUN O
; PUNCT O
CTRL NOUN B-AC
= PUNCT O
control NOUN O
; PUNCT O
HF NOUN B-AC
= PUNCT O
high ADJ B-LF
- NOUN I-LF
fat NOUN I-LF
; PUNCT O
WT NOUN B-AC
= PUNCT O
wild NOUN B-LF
- NOUN I-LF
type NOUN I-LF
. PUNCT O

Lactate NOUN B-LF
Dehydrogenase NOUN I-LF
L NOUN O
- NOUN O
P PROPN O
( PUNCT O
LDH PROPN B-AC
) PUNCT O
activity NOUN O
was AUX O
measured VERB O
by ADP O
its PRON O
conversion NOUN O
of ADP O
L NOUN O
- NOUN O
lactate NOUN O
to ADP O
pyruvate NOUN O
in ADP O
the DET O
presence NOUN O
of ADP O
nicotinamide NOUN O
adenine NOUN O
dinucleotide NOUN O
based VERB O
on ADP O
the DET O
method NOUN O
of ADP O
Amador PROPN O
et X O
al NOUN O
. PUNCT O
[ PUNCT O
20 NUM O
] PUNCT O
. PUNCT O

Human ADJ O
semen NOUN O
has VERB O
the DET O
potential NOUN O
to PART O
modulate VERB O
the DET O
epithelial ADJ O
mucosal ADJ O
tissues NOUN O
it PRON O
contacts VERB O
, PUNCT O
as SCONJ O
seminal ADJ B-LF
plasma NOUN I-LF
( PUNCT O
SP PROPN B-AC
) PUNCT O
is AUX O
recognized VERB O
to PART O
contain VERB O
both CCONJ O
pro- ADJ O
and CCONJ O
anti ADJ O
- ADJ O
barrier NOUN O
components NOUN O
, PUNCT O
yet CCONJ O
its PRON O
effects NOUN O
on ADP O
epithelial ADJ O
barrier NOUN O
function NOUN O
are AUX O
largely ADV O
unknown ADJ O
. PUNCT O

One NUM O
potential ADJ O
link NOUN O
between ADP O
RP PROPN B-AC
expression NOUN O
and CCONJ O
S NOUN O
- PUNCT O
phase NOUN O
is AUX O
the DET O
ultradian ADJ O
yeast NOUN B-LF
metabolic ADJ I-LF
cycle NOUN I-LF
( PUNCT O
YMC PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
can AUX O
be AUX O
synchronized VERB O
in ADP O
bulk ADJ O
cultures NOUN O
through ADP O
nutrient NOUN O
deprivation NOUN O
and CCONJ O
has AUX O
recently ADV O
been AUX O
reported VERB O
in ADP O
asynchronous ADJ O
, PUNCT O
nutrient NOUN O
- PUNCT O
replete ADJ O
cultures NOUN O
[ X O
59–62 NUM O
] PUNCT O
. PUNCT O

In ADP O
the DET O
human ADJ O
neocortex NOUN O
, PUNCT O
single ADJ O
excitatory ADJ O
pyramidal ADJ O
cells NOUN O
can AUX O
elicit VERB O
very ADV B-LF
large ADJ I-LF
glutamatergic ADJ I-LF
EPSPs NOUN I-LF
( PUNCT O
VLEs NOUN B-AC
) PUNCT O
in ADP O
inhibitory ADJ O
GABAergic ADJ O
interneurons NOUN O
capable ADJ O
of ADP O
triggering VERB O
their PRON O
firing NOUN O
with ADP O
short ADJ O
( PUNCT O
3–5 NUM O
ms NOUN O
) PUNCT O
delay NOUN O
. PUNCT O

BCR NOUN B-AC
, PUNCT O
biochemical ADJ B-LF
recurrence NOUN I-LF
. PUNCT O

Finally ADV O
, PUNCT O
combination NOUN O
therapy NOUN O
increased VERB O
the DET O
expression NOUN O
of ADP O
mammalian ADJ B-LF
target NOUN I-LF
of ADP I-LF
rapamycin NOUN I-LF
( PUNCT O
mTOR NOUN B-AC
) PUNCT O
, PUNCT O
the DET O
negative ADJ O
regulator NOUN O
of ADP O
functional ADJ O
autophagy NOUN O
, PUNCT O
in ADP O
both DET O
cell NOUN O
lines NOUN O
. PUNCT O

EBV PROPN B-AC
, PUNCT O
Epstein PROPN B-LF
– PUNCT I-LF
Barr PROPN I-LF
virus NOUN I-LF
; PUNCT O
KSHV PROPN B-AC
, PUNCT O
Kaposi PROPN B-LF
’s PART I-LF
sarcoma NOUN I-LF
- PUNCT I-LF
associated VERB I-LF
herpesvirus NOUN I-LF
; PUNCT O
NMD PROPN B-AC
, PUNCT O
nonsense NOUN B-LF
- PUNCT I-LF
mediated VERB I-LF
decay NOUN I-LF
; PUNCT O
qRT NOUN B-AC
- PUNCT B-AC
PCR NOUN B-AC
, PUNCT O
quantitative ADJ B-LF
reverse ADJ I-LF
transcription NOUN I-LF
PCR NOUN I-LF
; PUNCT O
siRNA NOUN B-AC
, PUNCT O
small ADJ B-LF
interfering VERB I-LF
RNA NOUN I-LF
. PUNCT O

IGFBP-1 PROPN B-AC
, PUNCT O
insulin NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
growth NOUN I-LF
factor NOUN I-LF
binding VERB I-LF
protein NOUN I-LF
1 NUM I-LF
; PUNCT O
PCSK9 PROPN B-AC
, PUNCT O
proprotein NOUN B-LF
convertase NOUN I-LF
subtilisin NOUN I-LF
/ SYM I-LF
kexin NOUN I-LF
type NOUN I-LF
9 NUM I-LF
; PUNCT O
PD PROPN B-AC
, PUNCT O
Parkinson PROPN B-LF
’s PART I-LF
disease NOUN I-LF
; PUNCT O
RFU PROPN B-AC
, PUNCT O
relative ADJ B-LF
fluorescence NOUN I-LF
unit NOUN I-LF
. PUNCT O

The DET O
final ADJ O
models NOUN O
considered VERB O
the DET O
following ADJ O
variables NOUN O
: PUNCT O
Clinical ADJ O
presentation NOUN O
( PUNCT O
STEMI PROPN B-AC
or CCONJ O
NSTE PROPN B-AC
- ADJ B-AC
ACS PROPN B-AC
) PUNCT O
, PUNCT O
age NOUN O
, PUNCT O
gender NOUN O
, PUNCT O
weight NOUN O
, PUNCT O
presence NOUN O
of ADP O
diabetes NOUN O
mellitus NOUN O
, PUNCT O
presence NOUN O
of ADP O
arterial ADJ O
hypertension NOUN O
, PUNCT O
presence NOUN O
of ADP O
hyperlipidaemia NOUN O
, PUNCT O
familiar ADJ O
history NOUN O
of ADP O
coronary ADJ B-LF
heart NOUN I-LF
disease NOUN I-LF
( PUNCT O
CHD PROPN B-AC
) PUNCT O
, PUNCT O
current ADJ O
or CCONJ O
prior ADJ O
smoking NOUN O
, PUNCT O
history NOUN O
of ADP O
chronic ADJ B-LF
obstructive ADJ I-LF
pulmonary ADJ I-LF
disease NOUN I-LF
( PUNCT O
COPD PROPN B-AC
) PUNCT O
, PUNCT O
site NOUN O
of ADP O
antiplatelet ADJ O
loading NOUN O
therapy NOUN O
, PUNCT O
presence NOUN O
of ADP O
atrial ADJ O
fibrillation NOUN O
, PUNCT O
active ADJ O
bleeding NOUN O
at ADP O
admission NOUN O
, PUNCT O
history NOUN O
of ADP O
stroke NOUN O
or CCONJ O
transient ADJ B-LF
ischemic ADJ I-LF
attack NOUN I-LF
( PUNCT O
TIA PROPN B-AC
) PUNCT O
, PUNCT O
history NOUN O
of ADP O
intracranial ADJ O
haemorrhage NOUN O
, PUNCT O
planned VERB O
operation NOUN O
and CCONJ O
peri ADJ O
- ADJ O
interventional ADJ O
anticoagulation ADJ O
treatment NOUN O
regimen NOUN O
regimen NOUN O
( PUNCT O
only ADV O
at ADP O
discharge NOUN O
) PUNCT O
. PUNCT O

AF PROPN B-AC
: PUNCT O
atrial ADJ B-LF
fibrillation NOUN I-LF
; PUNCT O
AFL PROPN B-AC
: PUNCT O
atrial ADJ B-LF
flutter NOUN I-LF
; PUNCT O
NOAC PROPN B-AC
: PUNCT O
non ADJ O
- ADJ O
vitamin ADJ O
K PROPN O
oral ADJ O
anticoagulant NOUN O
; PUNCT O
TEE PROPN B-AC
: PUNCT O
trans ADJ B-LF
- ADJ I-LF
esophageal ADJ I-LF
echocardiography NOUN I-LF
. PUNCT O

Vascular ADJ B-LF
smooth ADJ I-LF
muscle NOUN I-LF
cells NOUN I-LF
( PUNCT O
VSMCs NOUN B-AC
) PUNCT O
are AUX O
essential ADJ O
regulators NOUN O
of ADP O
vascular ADJ O
function NOUN O
[ X O
1,2 NUM O
] PUNCT O
. PUNCT O

FL PROPN O
- PUNCT O
p53 NOUN O
, PUNCT O
full ADJ O
- PUNCT O
length NOUN O
p53 NOUN O
; PUNCT O
PTC PROPN B-AC
, PUNCT O
premature ADJ B-LF
termination NOUN I-LF
codon NOUN I-LF
; PUNCT O
RNA NOUN B-AC
- PUNCT B-AC
seq NOUN B-AC
, PUNCT O
RNA NOUN B-LF
sequencing NOUN I-LF
; PUNCT O
TR NOUN O
- PUNCT O
p53 NOUN O
, PUNCT O
truncated VERB O
p53 NOUN O
. PUNCT O

Immunosenescence NOUN O
with ADP O
exhaustion NOUN O
of ADP O
plasmacytoid ADJ O
dendritic ADJ O
cells NOUN O
, PUNCT O
natural ADJ B-LF
killer NOUN I-LF
( PUNCT O
NK PROPN B-AC
) PUNCT O
cells NOUN O
and CCONJ O
cytotoxic ADJ O
CD8 PROPN O
+ NOUN O
T PROPN O
cells NOUN O
, PUNCT O
which PRON O
form VERB O
the DET O
frontline NOUN O
of ADP O
cellular ADJ O
innate ADJ O
and CCONJ O
adaptive ADJ O
anti ADJ O
- ADJ O
viral ADJ O
immune ADJ O
defense NOUN O
, PUNCT O
would AUX O
seem VERB O
a DET O
plausible ADJ O
explanation NOUN O
of ADP O
the DET O
inadequacy NOUN O
of ADP O
the DET O
aging VERB O
immune ADJ O
system NOUN O
to PART O
clear VERB O
this DET O
virus NOUN O
efficiently ADV O
[ PUNCT O
16–19 NUM O
] PUNCT O
. PUNCT O

Both DET O
ORs NOUN B-AC
and CCONJ O
MDs NOUN B-AC
are AUX O
reported VERB O
with ADP O
95 NUM O
% NOUN O
confidence NOUN B-LF
intervals NOUN I-LF
( PUNCT O
CIs NOUN B-AC
) PUNCT O
. PUNCT O

Whereas SCONJ O
NaR PROPN B-AC
shares VERB O
with ADP O
NR PROPN B-AC
the DET O
ability NOUN O
to PART O
be AUX O
utilized VERB O
by ADP O
bna1 NOUN O
npt1 NOUN O
and CCONJ O
bna1 NOUN O
nrk1 NOUN O
mutants NOUN O
, PUNCT O
the DET O
Qns1 PROPN O
requirement NOUN O
for ADP O
NaR PROPN B-AC
indicates VERB O
that SCONJ O
NaR PROPN B-AC
metabolites NOUN O
must AUX O
flow VERB O
through ADP O
nicotinic ADJ B-LF
acid NOUN I-LF
mononucleotide NOUN I-LF
( PUNCT O
NaMN PROPN B-AC
) PUNCT O
and CCONJ O
nicotinic ADJ B-LF
acid NOUN I-LF
adenine NOUN I-LF
dinucleotide NOUN I-LF
( PUNCT O
NaAD PROPN B-AC
) PUNCT O
as SCONJ O
schematized VERB O
in ADP O
Figure PROPN O
7 NUM O
. PUNCT O

Indicated VERB O
are AUX O
the DET O
cerebral ADJ B-LF
cortex NOUN I-LF
( PUNCT O
CX NOUN B-AC
) PUNCT O
, PUNCT O
the DET O
hippocampus NOUN B-LF
( PUNCT O
HP NOUN B-AC
) PUNCT O
, PUNCT O
the DET O
thalamus NOUN B-LF
( PUNCT O
TH NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
the DET O
putamen NOUN B-LF
( PUNCT O
PU NOUN B-AC
) PUNCT O
. PUNCT O

Potential ADJ O
risk NOUN O
factors NOUN O
for ADP O
neonatal ADJ O
mortality NOUN O
were AUX O
grouped VERB O
into ADP O
the DET O
following ADJ O
categories NOUN O
: PUNCT O
( PUNCT O
i X O
) PUNCT O
Infants NOUN O
’ PART O
individual ADJ O
characteristics NOUN O
: PUNCT O
sex NOUN O
( PUNCT O
male ADJ O
and CCONJ O
female ADJ O
) PUNCT O
, PUNCT O
gestational ADJ O
age NOUN O
( PUNCT O
< PUNCT O
34 NUM O
, PUNCT O
34–36 NUM O
, PUNCT O
and CCONJ O
≥37 NUM O
weeks NOUN O
) PUNCT O
, PUNCT O
multiple ADJ O
gestations NOUN O
( PUNCT O
yes INTJ O
and CCONJ O
no DET O
) PUNCT O
, PUNCT O
and CCONJ O
birth NOUN O
rank NOUN O
( PUNCT O
1st ADJ O
, PUNCT O
2nd ADJ O
to ADP O
4th ADJ O
, PUNCT O
and CCONJ O
5th ADJ O
or CCONJ O
higher ADJ O
) PUNCT O
; PUNCT O
( PUNCT O
ii X O
) PUNCT O
Maternal ADJ O
characteristics NOUN O
: PUNCT O
birth NOUN O
interval NOUN O
( PUNCT O
≤2 NUM O
and CCONJ O
2–4 NUM O
years NOUN O
) PUNCT O
, PUNCT O
maternal ADJ O
age NOUN O
( PUNCT O
< PUNCT O
18 NUM O
, PUNCT O
18–24 NUM O
, PUNCT O
25–29 NUM O
, PUNCT O
30–34 NUM O
, PUNCT O
and CCONJ O
≥35 NUM O
years NOUN O
) PUNCT O
, PUNCT O
maternal ADJ O
mid ADJ B-LF
- PUNCT I-LF
upper ADJ I-LF
arm NOUN I-LF
circumference NOUN I-LF
( PUNCT O
MUAC PROPN B-AC
) PUNCT O
( PUNCT O
< PUNCT O
22 NUM O
and CCONJ O
≥22 NUM O
cm NOUN O
) PUNCT O
, PUNCT O
history NOUN O
of ADP O
previous ADJ O
child NOUN O
death NOUN O
( PUNCT O
yes INTJ O
and CCONJ O
no DET O
) PUNCT O
; PUNCT O
( PUNCT O
iii X O
) PUNCT O
Antenatal ADJ O
factors NOUN O
: PUNCT O
antenatal ADJ O
complications NOUN O
( PUNCT O
pregnancy NOUN O
complications NOUN O
such ADJ O
as ADP O
high ADJ O
grade NOUN O
fever NOUN O
, PUNCT O
excessive ADJ O
bleeding NOUN O
, PUNCT O
convulsion NOUN O
, PUNCT O
swelling NOUN O
of ADP O
face NOUN O
or CCONJ O
feet NOUN O
, PUNCT O
foul ADJ O
smelling VERB O
discharge NOUN O
or CCONJ O
others NOUN O
) PUNCT O
, PUNCT O
number NOUN O
of ADP O
antenatal ADJ O
care NOUN O
seeking VERB O
visits NOUN O
( PUNCT O
no DET O
antenatal ADJ O
visit NOUN O
, PUNCT O
1–3 NUM O
, PUNCT O
and CCONJ O
≥4 NUM O
visits NOUN O
) PUNCT O
, PUNCT O
receiving VERB O
a DET O
tetanus NOUN O
toxoid NOUN O
injection NOUN O
( PUNCT O
yes INTJ O
and CCONJ O
no DET O
) PUNCT O
, PUNCT O
and CCONJ O
tobacco NOUN O
consumption NOUN O
during ADP O
pregnancy NOUN O
( PUNCT O
yes INTJ O
and CCONJ O
no DET O
) PUNCT O
; PUNCT O
( PUNCT O
iv X O
) PUNCT O
Intrapartum ADJ O
factors NOUN O
: PUNCT O
delivery NOUN O
complications NOUN O
such ADJ O
as ADP O
excessive ADJ O
bleeding NOUN O
, PUNCT O
convulsions NOUN O
, PUNCT O
retained VERB O
placenta NOUN O
, PUNCT O
abnormal ADJ O
presentation NOUN O
, PUNCT O
prolonged ADJ O
labor NOUN O
, PUNCT O
premature ADJ O
water NOUN O
breaking NOUN O
, PUNCT O
or CCONJ O
others NOUN O
( PUNCT O
yes INTJ O
and CCONJ O
no DET O
) PUNCT O
, PUNCT O
place NOUN O
of ADP O
delivery NOUN O
( PUNCT O
hospital NOUN O
and CCONJ O
home NOUN O
delivery NOUN O
) PUNCT O
, PUNCT O
delivery NOUN O
assistance NOUN O
( PUNCT O
by ADP O
skilled ADJ O
birth NOUN O
attendants NOUN O
, PUNCT O
[ PUNCT O
doctors NOUN O
and CCONJ O
nurses NOUN O
were AUX O
included VERB O
as ADP O
skilled ADJ O
birth NOUN O
attendants NOUN O
] PUNCT O
; PUNCT O
yes INTJ O
and CCONJ O
no DET O
) PUNCT O
, PUNCT O
and CCONJ O
season NOUN O
of ADP O
delivery NOUN O
( PUNCT O
winter NOUN O
or CCONJ O
not PART O
winter NOUN O
) PUNCT O
; PUNCT O
and CCONJ O
finally ADV O
( PUNCT O
v X O
) PUNCT O
Socio ADJ O
- PUNCT O
economic ADJ O
and CCONJ O
household NOUN O
factors NOUN O
: PUNCT O
maternal ADJ O
education NOUN O
( PUNCT O
no DET O
formal ADJ O
education NOUN O
, PUNCT O
primary ADJ O
, PUNCT O
and CCONJ O
secondary ADJ O
or CCONJ O
above ADV O
) PUNCT O
, PUNCT O
women NOUN O
work VERB O
for ADP O
cash NOUN O
( PUNCT O
yes INTJ O
and CCONJ O
no DET O
) PUNCT O
, PUNCT O
women NOUN O
’s PART O
decision NOUN O
- PUNCT O
making VERB O
power NOUN O
about ADP O
treatment NOUN O
of ADP O
children NOUN O
( PUNCT O
yes INTJ O
and CCONJ O
no DET O
) PUNCT O
, PUNCT O
paternal ADJ O
education NOUN O
( PUNCT O
no DET O
formal ADJ O
education NOUN O
, PUNCT O
primary ADJ O
, PUNCT O
and CCONJ O
secondary ADJ O
or CCONJ O
above ADV O
) PUNCT O
, PUNCT O
and CCONJ O
household NOUN O
economic ADJ O
status NOUN O
( PUNCT O
poorest ADJ O
, PUNCT O
poorer ADJ O
, PUNCT O
middle ADJ O
, PUNCT O
richer ADJ O
, PUNCT O
and CCONJ O
richest ADJ O
) PUNCT O
( PUNCT O
Fig NOUN O
1 NUM O
) PUNCT O
. PUNCT O

We PRON O
performed VERB O
external ADJ O
evaluation NOUN O
of ADP O
the DET O
models NOUN O
by ADP O
evaluating VERB O
performance NOUN O
on ADP O
the DET O
National PROPN B-LF
Institutes PROPN I-LF
of ADP I-LF
Health PROPN I-LF
( PUNCT O
NIH PROPN B-AC
) PUNCT O
ChestX PROPN O
- NOUN O
ray14 NOUN O
set NOUN O
( PUNCT O
available ADJ O
at ADP O
https://nihcc.app.box.com/v/ChestXray-NIHCC X O
) PUNCT O
, PUNCT O
a DET O
publically ADV O
available ADJ O
dataset NOUN O
of ADP O
over ADP O
112,000 NUM O
frontal ADJ O
chest NOUN O
radiographs NOUN O
accompanied VERB O
by ADP O
labels NOUN O
extracted VERB O
from ADP O
accompanying VERB O
radiology NOUN O
reports NOUN O
using VERB O
natural ADJ O
language NOUN O
processing NOUN O
. PUNCT O

Intravenous ADJ O
fluids NOUN O
, PUNCT O
vasopressors NOUN O
, PUNCT O
and CCONJ O
inotropic ADJ O
support NOUN O
( PUNCT O
norepinephrine NOUN O
and/or CCONJ O
epinephrine NOUN O
) PUNCT O
were AUX O
administered VERB O
to PART O
achieve VERB O
and CCONJ O
maintain VERB O
an DET O
adequate ADJ O
cerebral ADJ B-LF
perfusion NOUN I-LF
pressure NOUN I-LF
( PUNCT O
CPP NOUN B-AC
> ADP O
60 NUM O
mm NOUN O
Hg NOUN O
) PUNCT O
. PUNCT O

Seven NUM O
of ADP O
15 NUM O
clinical ADJ O
trial NOUN O
participants NOUN O
treated VERB O
with ADP O
a DET O
nucleoside NOUN O
analogue NOUN O
( PUNCT O
fialuridine PROPN B-LF
[ X O
FIAU PROPN B-AC
] PUNCT O
) PUNCT O
developed VERB O
acute ADJ O
liver NOUN O
failure NOUN O
. PUNCT O

The DET O
effect NOUN O
of ADP O
temperature NOUN O
on ADP O
protease NOUN O
activity NOUN O
was AUX O
analysed VERB O
by ADP O
incubating VERB O
reaction NOUN O
mixture NOUN O
containing VERB O
partially ADV B-LF
purified VERB I-LF
extract NOUN I-LF
( PUNCT O
PPE PROPN B-AC
) PUNCT O
and CCONJ O
buffered VERB O
casein NOUN O
for ADP O
an PRON O
at ADP O
20 NUM O
° NOUN B-AC
C NOUN B-AC
, PUNCT O
30 NUM O
° NOUN B-AC
C,40 NUM O
° NOUN B-AC
C NOUN B-AC
, PUNCT O
50 NUM O
° NOUN B-AC
C NOUN B-AC
, PUNCT O
60 NUM O
° NOUN B-AC
C NOUN B-AC
, PUNCT O
70 NUM O
° NOUN B-AC
C NOUN B-AC
, PUNCT O
80 NUM O
° NOUN B-AC
C NOUN B-AC
, PUNCT O
90 NUM O
° NOUN B-AC
C NOUN B-AC
and CCONJ O
100 NUM O
° NOUN B-AC
C NOUN B-AC
. PUNCT O

The DET O
WHO PROPN B-AC
/ SYM O
UNICEF PROPN B-AC
’s PART O
Joint PROPN B-LF
Monitoring PROPN I-LF
Programme PROPN I-LF
( PUNCT O
JMP PROPN B-AC
) PUNCT O
tracked VERB O
progress NOUN O
toward ADP O
MDG PROPN B-AC
targets NOUN O
via ADP O
the DET O
drinking NOUN O
water NOUN O
and CCONJ O
sanitation NOUN O
ladders NOUN O
( PUNCT O
see VERB O
Box NOUN O
1 NUM O
) PUNCT O
. PUNCT O

Ag.pTfh PROPN B-AC
, PUNCT O
antigen NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
peripheral ADJ I-LF
T NOUN I-LF
follicular ADJ I-LF
helper NOUN I-LF
; PUNCT O
HC PROPN B-AC
, PUNCT O
healthy ADJ B-LF
control NOUN I-LF
; PUNCT O
PBMC PROPN B-AC
, PUNCT O
peripheral ADJ B-LF
blood NOUN I-LF
mononuclear ADJ I-LF
cell NOUN I-LF
; PUNCT O
VNR PROPN B-AC
, PUNCT O
vaccine NOUN B-LF
nonresponder NOUN I-LF
; PUNCT O
VR PROPN B-AC
, PUNCT O
vaccine NOUN B-LF
responder NOUN I-LF
. PUNCT O

bERCD PROPN O
( PUNCT O
elective ADJ O
repeat ADJ O
cesarean ADJ O
delivery NOUN O
) PUNCT O
, PUNCT O
VBAC PROPN B-AC
( PUNCT O
vaginal ADJ B-LF
birth NOUN I-LF
after ADP I-LF
cesarean ADJ I-LF
) PUNCT O
, PUNCT O
URCD PROPN B-AC
( PUNCT O
unplanned ADJ B-LF
repeat ADJ I-LF
cesarean ADJ I-LF
delivery NOUN I-LF
) PUNCT O

HEK PROPN B-AC
, PUNCT O
human ADJ B-LF
embryonic ADJ I-LF
kidney NOUN I-LF
. PUNCT O

We PRON O
isolated VERB O
the DET O
precursor NOUN O
cell NOUN O
type NOUN O
of ADP O
DSCs NOUN B-AC
, PUNCT O
endometrial ADJ B-LF
stromal ADJ I-LF
fibroblasts NOUN I-LF
( PUNCT O
ESFs PROPN B-AC
) PUNCT O
, PUNCT O
from ADP O
the DET O
opossum NOUN O
Monodelphis PROPN O
domestica NOUN O
. PUNCT O

Length NOUN B-LF
of ADP I-LF
stay NOUN I-LF
( PUNCT O
LoS PROPN B-AC
) PUNCT O
, PUNCT O
resource NOUN B-LF
utilization NOUN I-LF
( PUNCT O
RU PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
predicted VERB O
diagnostic ADJ O
accuracy NOUN O
of ADP O
the DET O
1 NUM O
- PUNCT O
h NOUN O
algorithm NOUN O
compared VERB O
to ADP O
standard NOUN B-LF
of ADP I-LF
care NOUN I-LF
( PUNCT O
SoC PROPN B-AC
) PUNCT O
in ADP O
the DET O
ED PROPN B-AC
were AUX O
estimated VERB O
. PUNCT O

In ADP O
contrast NOUN O
to PART O
other ADJ O
studies NOUN O
which PRON O
showed VERB O
that SCONJ O
bedridden ADJ O
patients NOUN O
are AUX O
associated VERB O
with ADP O
lost VERB B-LF
to PART I-LF
follow VERB I-LF
up ADP I-LF
[ X O
15,32 NUM O
] PUNCT O
, PUNCT O
in ADP O
this DET O
study NOUN O
being AUX O
bed NOUN O
ridden VERB O
patient NOUN O
is AUX O
not PART O
associated VERB O
with ADP O
LTFU PROPN B-AC
. PUNCT O
This PRON O
might AUX O
be AUX O
because SCONJ O
of ADP O
in ADP O
this DET O
study NOUN O
there PRON O
were VERB O
small ADJ O
number NOUN O
of ADP O
bedridden ADJ O
patients NOUN O
( PUNCT O
very ADV O
small ADJ O
sample NOUN O
size NOUN O
) PUNCT O
which PRON O
may AUX O
result VERB O
a DET O
biased VERB O
statistical ADJ O
estimation NOUN O
. PUNCT O

Please INTJ O
add VERB O
the DET O
following ADJ O
statement NOUN O
, PUNCT O
or CCONJ O
similar ADJ O
, PUNCT O
to ADP O
the DET O
Methods NOUN O
: PUNCT O
" PUNCT O
This DET O
study NOUN O
is AUX O
reported VERB O
as ADP O
per ADP O
the DET O
Strengthening VERB B-LF
the DET I-LF
Reporting PROPN I-LF
of ADP I-LF
Observational PROPN I-LF
Studies PROPN I-LF
in ADP I-LF
Epidemiology PROPN I-LF
( PUNCT O
STROBE PROPN B-AC
) PUNCT O
guideline NOUN O
( PUNCT O
S1 PROPN O
Checklist PROPN O
) PUNCT O
. PUNCT O
" PUNCT O

However ADV O
, PUNCT O
the DET O
incidence NOUN O
and CCONJ O
mortality NOUN O
related VERB O
to ADP O
these DET O
conditions NOUN O
in ADP O
patients NOUN O
infected VERB O
with ADP O
hepatitis PROPN B-LF
C PROPN I-LF
virus NOUN I-LF
( PUNCT O
HCV PROPN B-AC
) PUNCT O
are AUX O
unclear ADJ O
, PUNCT O
as SCONJ O
is AUX O
whether SCONJ O
antiviral ADJ O
therapy NOUN O
could AUX O
change VERB O
their PRON O
infection NOUN O
risk NOUN O
. PUNCT O

Plasmodium NOUN B-LF
falciparum NOUN I-LF
strain NOUN I-LF
FCR3 NOUN I-LF

PSG PROPN B-AC
, PUNCT O
polysomnography NOUN B-LF
. PUNCT O

Directly ADV B-LF
observed VERB I-LF
treatment NOUN I-LF
, PUNCT I-LF
short ADJ I-LF
- PUNCT I-LF
course NOUN I-LF
( PUNCT O
DOTS PROPN B-AC
) PUNCT O
TB PROPN B-AC
treatment NOUN O
services NOUN O
are AUX O
given VERB O
in ADP O
all DET O
the DET O
health NOUN O
facilities NOUN O
. PUNCT O

The DET O
endoplasmic NOUN B-LF
reticulum NOUN I-LF
( PUNCT O
ER NOUN B-AC
) PUNCT O
is AUX O
responsible ADJ O
for ADP O
production NOUN O
and CCONJ O
folding NOUN O
of ADP O
secreted VERB O
proteins NOUN O
. PUNCT O

The DET O
resulting VERB O
equilibrium NOUN B-LF
dissociation NOUN I-LF
constants NOUN I-LF
KD NOUN B-AC
, PUNCT O
kinetic ADJ O
association NOUN O
kon NOUN O
and CCONJ O
dissociation NOUN O
koff NOUN O
rates NOUN O
are AUX O
given VERB O
in ADP O
Table PROPN O
2 NUM O
. PUNCT O

For ADP O
the DET O
competition NOUN O
assays NOUN O
between ADP O
N2 PROPN O
and CCONJ O
JU1648 PROPN O
, PUNCT O
we PRON O
used VERB O
a DET O
generalized ADJ B-LF
linear ADJ I-LF
model NOUN I-LF
( PUNCT O
GLM PROPN B-AC
) PUNCT O
to PART O
assess VERB O
the DET O
variation NOUN O
of ADP O
nath-10(haw6805 NOUN O
) PUNCT O
allele NOUN O
frequency NOUN O
over ADP O
time NOUN O
and CCONJ O
across ADP O
growth NOUN O
conditions NOUN O
. PUNCT O

KV PROPN B-AC
, PUNCT O
Kupffer PROPN B-LF
’s PART I-LF
vesicle NOUN I-LF
; PUNCT O
α NOUN B-AC
- NOUN B-AC
Tubulin NOUN B-AC
, PUNCT O
acetylated VERB B-LF
tubulin NOUN I-LF
. PUNCT O

The DET O
longer ADJ O
of ADP O
the DET O
two NUM O
most ADV O
highly ADV O
conserved ADJ O
elements NOUN O
at ADP O
Or42a PROPN O
, PUNCT O
42a4 PROPN O
, PUNCT O
contains VERB O
an DET O
inverted ADJ O
repeat NOUN O
: PUNCT O
AGTGTAAAAGTTTACACTT NOUN O
. PUNCT O
We PRON O
were AUX O
surprised ADJ O
to ADP O
find VERB O
that SCONJ O
mutation NOUN O
of ADP O
this DET O
element NOUN O
led VERB O
to ADP O
a DET O
2 ADJ O
- PUNCT O
fold ADJ O
increase NOUN O
in ADP O
the DET O
number NOUN O
of ADP O
labeled VERB O
maxillary ADJ O
palp NOUN O
cells NOUN O
, PUNCT O
from ADP O
18.2 NUM O
± SYM O
1.8 NUM O
( PUNCT O
n NOUN O
= SYM O
9 NUM O
maxillary ADJ O
palps NOUN O
) PUNCT O
to ADP O
33.2 NUM O
± SYM O
3.7 NUM O
( PUNCT O
n NOUN O
= SYM O
9 NUM O
maxillary ADJ O
palps NOUN O
quantified VERB O
from ADP O
two NUM O
independent ADJ O
lines NOUN O
; PUNCT O
n NOUN O
= SYM O
8 NUM O
independent ADJ O
lines NOUN O
examined VERB O
, PUNCT O
n NOUN O
> SYM O
20 NUM O
maxillary ADJ O
palps NOUN O
examined VERB O
/ SYM O
line NOUN O
) PUNCT O
( PUNCT O
Figure PROPN O
3A–3C NUM O
) PUNCT O
. PUNCT O
The DET O
simplest ADJ O
interpretation NOUN O
of ADP O
this DET O
result NOUN O
is AUX O
that SCONJ O
42a4 PROPN O
is AUX O
a DET O
negative ADJ O
regulatory ADJ O
element NOUN O
that SCONJ O
represses VERB O
Or42a PROPN O
in ADP O
a DET O
subset NOUN O
of ADP O
ORNs PROPN B-AC
. PUNCT O
To PART O
test VERB O
this DET O
interpretation NOUN O
, PUNCT O
we PRON O
first ADV O
carried VERB O
out ADP O
a DET O
double ADJ O
- PUNCT O
label NOUN O
experiment NOUN O
using VERB O
probes NOUN O
for ADP O
the DET O
endogenous ADJ O
Or42a PROPN O
mRNA NOUN O
and CCONJ O
for ADP O
the DET O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
( PUNCT O
GFP PROPN B-AC
) PUNCT O
that SCONJ O
is AUX O
driven VERB O
by ADP O
the DET O
mutant ADJ O
promoter NOUN O
via ADP O
GAL4 PROPN O
. PUNCT O
We PRON O
found VERB O
that SCONJ O
all DET O
Or42a+ PROPN O
cells NOUN O
express VERB O
GFP PROPN B-AC
, PUNCT O
but CCONJ O
that SCONJ O
GFP PROPN B-AC
is AUX O
also ADV O
expressed VERB O
in ADP O
an DET O
additional ADJ O
subset NOUN O
of ADP O
cells NOUN O
( PUNCT O
Figure PROPN O
3D NUM O
) PUNCT O
. PUNCT O

A DET O
GWAS NOUN B-AC
for ADP O
CAD PROPN B-AC
conducted VERB O
in ADP O
the DET O
Chinese ADJ O
Han PROPN O
population NOUN O
had AUX O
identified VERB O
a DET O
variant NOUN O
, PUNCT O
rs6903956 NOUN O
, PUNCT O
within ADP O
intron NOUN O
1 NUM O
of ADP O
the DET O
C6orf105 PROPN O
gene NOUN O
( PUNCT O
also ADV O
known VERB O
as ADP O
the DET O
androgen NOUN B-LF
dependent ADJ I-LF
tissue NOUN I-LF
factor NOUN I-LF
pathway NOUN I-LF
inhibitor NOUN I-LF
regulating VERB I-LF
protein NOUN I-LF
or CCONJ O
ADTRP PROPN B-AC
) PUNCT O
on ADP O
chromosome NOUN O
6p24.1 NUM O
. PUNCT O

RT NOUN B-AC
: PUNCT O
radiation NOUN B-LF
. PUNCT O

Motor NOUN B-LF
thresholds NOUN I-LF
( PUNCT O
MTs NOUN B-AC
) PUNCT O
were AUX O
measured VERB O
at ADP O
the DET O
relaxed ADJ O
first ADJ B-LF
dorsal ADJ I-LF
interosseous ADJ I-LF
( PUNCT O
FDI PROPN B-AC
) PUNCT O
muscle NOUN O
of ADP O
the DET O
right ADJ O
hand NOUN O
using VERB O
single ADJ O
- PUNCT O
pulse NOUN O
TMS NOUN O
[ X O
20,46,71 NUM O
] PUNCT O
. PUNCT O

Two NUM O
proteins NOUN O
of ADP O
interest NOUN O
X NOUN O
and CCONJ O
Y NOUN O
are AUX O
fused VERB O
to ADP O
the DET O
N NOUN B-LF
- PUNCT I-LF
terminal NOUN I-LF
half NOUN I-LF
of ADP I-LF
ubiquitin NOUN I-LF
and CCONJ O
to ADP O
the DET O
C NOUN B-LF
- PUNCT I-LF
terminal NOUN I-LF
half NOUN I-LF
of ADP I-LF
ubiquitin NOUN I-LF
extended VERB O
by ADP O
the DET O
RUra3 PROPN O
reporter NOUN O
, PUNCT O
Nub PROPN B-AC
and CCONJ O
Cub PROPN B-AC
- PUNCT O
RUra3 PROPN O
, PUNCT O
respectively ADV O
. PUNCT O

QEESI PROPN B-AC
, PUNCT O
Quick PROPN O
Environmental PROPN O
Exposure PROPN O
and CCONJ O
Sensitivity PROPN O
Inventory PROPN O
; PUNCT O
MCS PROPN B-AC
, PUNCT O
multiple ADJ B-LF
chemical NOUN I-LF
sensitivity NOUN I-LF

Plasma NOUN O
HIV PROPN O
- PUNCT O
RNA NOUN O
viral ADJ B-LF
load NOUN I-LF
( PUNCT O
VL PROPN B-AC
) PUNCT O
testing NOUN O
for ADP O
the DET O
early ADJ O
diagnosis NOUN O
of ADP O
paediatric ADJ O
HIV PROPN O
infection NOUN O
was AUX O
performed VERB O
using VERB O
a DET O
quantitative ADJ O
real ADJ O
- PUNCT O
time NOUN O
RT NOUN O
- PUNCT O
PCR NOUN O
technique NOUN O
targeted VERB O
at ADP O
the DET O
HIV-1 PROPN O
LTR PROPN O
gene NOUN O
as SCONJ O
previously ADV O
validated VERB O
[ PUNCT O
25 NUM O
] PUNCT O
. PUNCT O

SSAO PROPN B-AC
, PUNCT O
semicarbazide NOUN B-LF
- PUNCT I-LF
sensitive ADJ I-LF
amine NOUN I-LF
oxidase NOUN I-LF
. PUNCT O

Three NUM O
hundred NUM O
and CCONJ O
fifteen NUM O
Diversity PROPN O
Array PROPN O
Technology PROPN O
( PUNCT O
DArT PROPN O
) PUNCT O
markers NOUN O
and CCONJ O
84 NUM O
Simple PROPN O
Sequence PROPN O
Repeat PROPN O
( PUNCT O
SSR PROPN O
) PUNCT O
markers NOUN O
and CCONJ O
phenotypic ADJ O
data NOUN O
were AUX O
subjected VERB O
to PART O
MapQTL5.0 PROPN O
[ X O
18 NUM O
] X O
to PART O
identify VERB O
Quantitative PROPN B-LF
Traits PROPN I-LF
Loci/ PROPN I-LF
locus NOUN I-LF
( PUNCT O
QTL PROPN B-AC
) PUNCT O
linked VERB O
with ADP O
plant NOUN O
height NOUN O
at ADP O
maturity NOUN O
, PUNCT O
germination NOUN O
percentage NOUN O
in ADP O
salinity NOUN O
stress NOUN O
, PUNCT O
biomass NOUN O
yield NOUN O
at ADP O
seedling NOUN O
emergence NOUN O
and CCONJ O
first ADJ O
leaf NOUN O
full ADJ O
expansion NOUN O
growth NOUN O
stages NOUN O
. PUNCT O

During ADP O
five NUM O
years NOUN O
, PUNCT O
adverse ADJ O
events NOUN O
, PUNCT O
survival NOUN O
rates NOUN O
for ADP O
grafts NOUN O
and CCONJ O
patients NOUN O
, PUNCT O
and CCONJ O
incidence NOUN O
of ADP O
biopsy NOUN B-LF
- PUNCT I-LF
proven VERB I-LF
acute ADJ I-LF
rejection NOUN I-LF
( PUNCT O
BPAR PROPN B-AC
) PUNCT O
and CCONJ O
dnDSA NOUN B-AC
production NOUN O
for ADP O
the DET O
two NUM O
groups NOUN O
were AUX O
monitored VERB O
and CCONJ O
compared VERB O
. PUNCT O

KO PROPN B-AC
, PUNCT O
knockout NOUN B-LF
; PUNCT O
KO PROPN B-AC
- PUNCT O
B PROPN O
, PUNCT O
knockout NOUN B-LF
, PUNCT O
C57BL/6 PROPN O
; PUNCT O
KO PROPN B-AC
- PUNCT O
H PROPN O
, PUNCT O
knockout NOUN B-LF
, PUNCT O
hybrid NOUN O
; PUNCT O
L NOUN O
, PUNCT O
left ADJ O
; PUNCT O
ns NOUN O
, PUNCT O
not PART O
significant ADJ O
; PUNCT O
O NOUN O
, PUNCT O
opposite ADJ O
; PUNCT O
R NOUN O
, PUNCT O
right ADJ O
; PUNCT O
T NOUN O
, PUNCT O
target NOUN O
quadrant NOUN O
; PUNCT O
WT NOUN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

Extracellular ADJ O
application NOUN O
of ADP O
a DET O
selective ADJ O
Group PROPN O
I NUM O
mGluR NOUN O
agonist NOUN O
( PUNCT O
S)-3,5 NOUN O
- PUNCT O
Dihydroxyphenylglycine NOUN O
( PUNCT O
DHPG PROPN B-AC
) PUNCT O
( PUNCT O
10 NUM O
μM NOUN O
) PUNCT O
for ADP O
3 NUM O
min NOUN O
induced VERB O
a DET O
rapid ADJ O
reduction NOUN O
of ADP O
GlyR NOUN B-AC
- PUNCT O
IPSCs NOUN B-AC
( PUNCT O
Fig NOUN O
1A NUM O
) PUNCT O
. PUNCT O
This DET O
synaptic ADJ O
depression NOUN O
was AUX O
specific ADJ O
to ADP O
glycinergic ADJ O
responses NOUN O
because SCONJ O
the DET O
same ADJ O
DHPG PROPN B-AC
treatment NOUN O
generated VERB O
no DET O
changes NOUN O
in ADP O
the DET O
amplitudes NOUN O
of ADP O
γ NOUN O
- PUNCT O
Aminobutyric ADJ O
acid NOUN O
type NOUN O
A PROPN O
( PUNCT O
GABAA)-receptor NOUN O
– PUNCT O
mediated VERB O
IPSCs NOUN B-AC
( PUNCT O
Fig NOUN O
1B NUM O
) PUNCT O
. PUNCT O
Group PROPN O
I NUM O
mGluRs NOUN O
consist VERB O
of ADP O
two NUM O
subtypes NOUN O
: PUNCT O
mGluR1 NOUN O
and CCONJ O
mGluR5 NOUN B-AC
. PUNCT O
To PART O
determine VERB O
which DET O
subtype NOUN O
was AUX O
responsible ADJ O
for ADP O
DHPG PROPN B-AC
action NOUN O
, PUNCT O
we PRON O
pretreated VERB O
the DET O
slices NOUN O
with ADP O
selective ADJ O
mGluR1 NOUN O
antagonist NOUN O
CPCCOEt PROPN O
or CCONJ O
mGluR5 NOUN B-AC
antagonist NOUN O
6 NUM B-LF
- PUNCT I-LF
Methyl-2-(phenylethynyl NOUN I-LF
) PUNCT I-LF
pyridine NOUN I-LF
( PUNCT O
MPEP PROPN B-AC
) PUNCT O
before ADP O
DHPG PROPN B-AC
application NOUN O
. PUNCT O

The DET O
pr NOUN B-AC
locus NOUN O
encodes VERB O
an DET O
enzyme NOUN O
, PUNCT O
which PRON O
, PUNCT O
along ADP O
with ADP O
Punch PROPN B-LF
( PUNCT O
Pu PROPN B-AC
) PUNCT O
and CCONJ O
Sepiapterin NOUN B-LF
reductase NOUN I-LF
( PUNCT O
Sptr PROPN B-AC
) PUNCT O
, PUNCT O
functions VERB O
in ADP O
the DET O
synthesis NOUN O
of ADP O
the DET O
enzymatic ADJ O
cofactor NOUN O
tetrahydrobiopterin NOUN B-LF
( PUNCT O
BH4 PROPN B-AC
) PUNCT O
. PUNCT O

Primary ADJ B-LF
sclerosing ADJ I-LF
cholangitis NOUN I-LF
( PUNCT O
PSC PROPN B-AC
) PUNCT O
is AUX O
a DET O
chronic ADJ O
inflammatory ADJ O
disease NOUN O
of ADP O
intra- ADJ O
and CCONJ O
extrahepatic ADJ O
bile NOUN O
ducts NOUN O
with ADP O
characteristic ADJ O
strictures NOUN O
and CCONJ O
bile NOUN O
duct NOUN O
obstruction NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

NADPH NOUN B-AC
oxidases NOUN O
are AUX O
plasma NOUN B-LF
membrane NOUN I-LF
( PUNCT O
PM)-bound NOUN B-AC
enzymes NOUN O
with ADP O
six NUM O
trans NOUN O
- NOUN O
membrane NOUN O
domains NOUN O
, PUNCT O
an DET O
N NOUN O
- NOUN O
terminal NOUN O
region NOUN O
that PRON O
contains VERB O
EF NOUN O
- NOUN O
hands NOUN O
, PUNCT O
and CCONJ O
a DET O
C NOUN O
- NOUN O
terminal NOUN O
oxidase NOUN O
domain NOUN O
responsible ADJ O
for ADP O
oxidizing VERB O
O2 NOUN O
to PART O
produce VERB O
superoxide NOUN O
radicals NOUN O
in ADP O
the DET O
apoplast NOUN O
( PUNCT O
reviewed VERB O
in ADP O
[ X O
13],[14 NUM O
] PUNCT O
) PUNCT O
. PUNCT O

FEF25 NUM O
- SYM O
75 NUM O
% NOUN O
: PUNCT O
forced VERB O
expiratory ADJ O
flow NOUN O
at ADP O
25–75 NUM O
% NOUN O
of ADP O
FVC PROPN B-AC
. PUNCT O
FEV1 PROPN B-AC
: PUNCT O
1st ADJ B-LF
s NOUN I-LF
forced VERB I-LF
expiratory ADJ I-LF
volume NOUN I-LF
. PUNCT O

AACE PROPN O
: PUNCT O
American PROPN O
College PROPN O
of ADP O
Endocrinology PROPN O
; PUNCT O
AHA PROPN B-AC
/ SYM B-AC
NHLBI PROPN B-AC
: PUNCT O
American PROPN B-LF
Heart PROPN I-LF
Association PROPN I-LF
and CCONJ I-LF
National PROPN I-LF
Heart PROPN I-LF
Lung PROPN I-LF
and CCONJ I-LF
Blood PROPN I-LF
Institute PROPN I-LF
; PUNCT O
IDF PROPN B-AC
: PUNCT O
International PROPN B-LF
Diabetes PROPN I-LF
Federation PROPN I-LF
; PUNCT O
JIS PROPN B-AC
: PUNCT O
Joint PROPN B-LF
Interim PROPN I-LF
Statement PROPN I-LF
; PUNCT O
NCEP PROPN O
- PUNCT O
ATPIII PROPN O
: PUNCT O
National PROPN O
Cholesterol PROPN O
Education PROPN O
Program PROPN O
Adult PROPN O
Treatment PROPN O
Panel PROPN O
III NUM O
; PUNCT O
WHO PROPN B-AC
: PUNCT O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
; PUNCT O
DM NOUN B-AC
: PUNCT O
diabetes NOUN B-LF
mellitus NOUN I-LF
; PUNCT O
T2DM NOUN B-AC
: PUNCT O
Type NOUN B-LF
2 NUM I-LF
Diabetes PROPN I-LF
mellitus NOUN I-LF
; PUNCT O
HDL NOUN B-AC
- PUNCT O
c NOUN O
: PUNCT O
high ADJ B-LF
density NOUN I-LF
lipoprotein NOUN I-LF
; PUNCT O
BMI NOUN B-AC
: PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
BP NOUN B-AC
: PUNCT O
bloodpPressure NOUN O
; PUNCT O
WC NOUN B-AC
: PUNCT O
waist NOUN B-LF
circumference NOUN I-LF
; PUNCT O
FG NOUN B-AC
: PUNCT O
fasting VERB B-LF
glucose NOUN I-LF
; PUNCT O
HBP NOUN B-AC
: PUNCT O
high ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
. PUNCT O

Receiver NOUN B-LF
operating NOUN I-LF
characteristic NOUN I-LF
( PUNCT O
ROC PROPN B-AC
) PUNCT O
curve NOUN O
was AUX O
plotted VERB O
by ADP O
“ PUNCT O
pROC NOUN O
” PUNCT O
package NOUN O
of ADP O
R PROPN O
[ X O
26 NUM O
] PUNCT O
. PUNCT O

Celiac PROPN B-LF
disease NOUN I-LF
( PUNCT O
CD NOUN B-AC
) PUNCT O
is AUX O
a DET O
chronic ADJ O
immune ADJ O
- PUNCT O
mediated VERB O
disorder NOUN O
triggered VERB O
by ADP O
the DET O
ingestion NOUN O
of ADP O
gluten NOUN O
in ADP O
genetically ADV O
susceptible ADJ O
individuals NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

DC PROPN B-AC
, PUNCT O
dendritic ADJ B-LF
cell NOUN I-LF
. PUNCT O

FCS PROPN B-AC
, PUNCT O
fluorescence NOUN B-LF
correlation NOUN I-LF
spectroscopy NOUN I-LF
. PUNCT O

Examples NOUN O
are AUX O
the DET O
Ecopath PROPN B-LF
With ADP I-LF
Ecosim PROPN I-LF
( PUNCT O
EwE PROPN B-AC
) PUNCT O
[ PUNCT O
14 NUM O
] PUNCT O
and CCONJ O
Atlantis PROPN O
[ PUNCT O
15 NUM O
] PUNCT O
models NOUN O
. PUNCT O

To PART O
examine VERB O
the DET O
relationship NOUN O
between ADP O
optical ADJ B-LF
coherence NOUN I-LF
tomography NOUN I-LF
( PUNCT O
OCT PROPN B-AC
) PUNCT O
images NOUN O
and CCONJ O
clinical ADJ O
course NOUN O
in ADP O
eyes NOUN O
with ADP O
branch NOUN B-LF
retinal ADJ I-LF
vein NOUN I-LF
occlusion NOUN I-LF
( PUNCT O
BRVO PROPN B-AC
) PUNCT O
treated VERB O
with ADP O
intravitreal ADJ B-LF
ranibizumab NOUN I-LF
injection NOUN O
( PUNCT O
IVR PROPN B-AC
) PUNCT O
. PUNCT O

CHI PROPN B-AC
, PUNCT O
community NOUN O
health NOUN O
index NOUN O
; PUNCT O
ISD PROPN B-AC
, PUNCT O
Information PROPN B-LF
Services PROPN I-LF
Division PROPN I-LF
; PUNCT O
NRS PROPN B-AC
, PUNCT O
National PROPN B-LF
Records PROPN I-LF
of ADP I-LF
Scotland PROPN I-LF
; PUNCT O
SMR02 PROPN B-AC
, PUNCT O
Scottish PROPN B-LF
Morbidity PROPN I-LF
Record PROPN I-LF
Maternity PROPN I-LF
Inpatient PROPN I-LF
and CCONJ I-LF
Day PROPN I-LF
Case PROPN I-LF
dataset NOUN I-LF
; PUNCT O
VBAC PROPN B-AC
, PUNCT O
vaginal ADJ B-LF
birth NOUN I-LF
after ADP I-LF
previous ADJ I-LF
cesarean NOUN I-LF
. PUNCT O

Dbx1 NOUN B-AC
, PUNCT O
developing VERB B-LF
brain NOUN I-LF
homeobox NOUN I-LF
1 NUM I-LF
; PUNCT O
preBötC NOUN B-AC
, PUNCT O
pre ADJ B-LF
- ADJ I-LF
Bötzinger ADJ I-LF
complex NOUN I-LF
; PUNCT O
Trp PROPN B-AC
, PUNCT O
transient ADJ B-LF
receptor NOUN I-LF
potential NOUN I-LF
. PUNCT O

Aussie PROPN B-AC
- PUNCT B-AC
FIT PROPN B-AC
builds VERB O
on ADP O
the DET O
FFIT PROPN B-AC
program NOUN O
, PUNCT O
the DET O
development NOUN O
and CCONJ O
evaluation NOUN O
of ADP O
which PRON O
was AUX O
undertaken VERB O
by ADP O
a DET O
research NOUN O
team NOUN O
led VERB O
by ADP O
the DET O
University PROPN O
of ADP O
Glasgow PROPN O
with ADP O
funding NOUN O
from ADP O
various ADJ O
grants NOUN O
including VERB O
a DET O
Medical PROPN B-LF
Research PROPN I-LF
Council PROPN I-LF
( PUNCT O
MRC PROPN B-AC
) PUNCT O
grant NOUN O
( PUNCT O
reference NOUN O
number NOUN O
MC_UU_12017/3 NUM O
) PUNCT O
, PUNCT O
a DET O
Chief PROPN B-LF
Scientist PROPN I-LF
Office PROPN I-LF
( PUNCT O
CSO PROPN B-AC
) PUNCT O
grant NOUN O
( PUNCT O
reference NOUN O
number NOUN O
CZG/2/504 NUM O
) PUNCT O
, PUNCT O
and CCONJ O
a DET O
National PROPN B-LF
Institute PROPN I-LF
for ADP I-LF
Health PROPN I-LF
Research PROPN I-LF
grant NOUN O
( PUNCT O
NIHR PROPN B-AC
) PUNCT O
( PUNCT O
reference NOUN O
number NOUN O
09/3010/06 NUM O
) PUNCT O
. PUNCT O

The DET O
volume NOUN B-LF
variations NOUN I-LF
of ADP I-LF
the DET I-LF
chest NOUN I-LF
wall NOUN I-LF
( PUNCT O
ΔVCW NOUN B-AC
) PUNCT O
and CCONJ O
its PRON O
compartments NOUN O
, PUNCT O
namely ADV O
pulmonary ADJ O
ribcage NOUN O
( PUNCT O
ΔVRC NOUN B-AC
, PUNCT B-AC
P NOUN B-AC
) PUNCT O
, PUNCT O
abdominal ADJ O
ribcage NOUN O
( PUNCT O
ΔVRC NOUN B-AC
, PUNCT B-AC
A NOUN B-AC
) PUNCT O
and CCONJ O
abdomen NOUN O
( PUNCT O
ΔVAB NOUN B-AC
) PUNCT O
were AUX O
measured VERB O
by ADP O
opto ADJ B-LF
- PUNCT I-LF
electronic ADJ I-LF
plethysmography NOUN I-LF
( PUNCT O
OEP PROPN B-AC
, PUNCT O
BTS PROPN O
, PUNCT O
Milan PROPN O
, PUNCT O
Italy)[47,48 NUM O
] PUNCT O
during ADP O
at ADV O
least ADV O
5 NUM O
minutes NOUN O
of ADP O
spontaneous ADJ O
QB NOUN B-AC
before ADV O
in ADP O
seated ADJ O
and CCONJ O
then ADV O
other ADJ O
5 NUM O
minutes NOUN O
in ADP O
supine ADJ O
position NOUN O
with ADP O
the DET O
child NOUN O
awake ADJ O
( PUNCT O
Brazelton PROPN O
stage NOUN O
4)[49 NUM O
] PUNCT O
while SCONJ O
watching VERB O
a DET O
cartoon NOUN O
( PUNCT O
Fig PROPN O
1 NUM O
) PUNCT O
. PUNCT O

BMI PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
. PUNCT O

Many ADJ O
regulatory ADJ O
neuropeptides NOUN O
and CCONJ O
neuropeptide NOUN O
receptors NOUN O
and CCONJ O
other ADJ O
crucial ADJ O
genes NOUN O
pertaining VERB O
to ADP O
molting NOUN O
have AUX O
been AUX O
identified VERB O
, PUNCT O
including VERB O
molt NOUN O
- PUNCT O
inhibiting VERB O
hormone NOUN O
( PUNCT O
MIH PROPN O
) PUNCT O
, PUNCT O
crustacean ADJ O
hyperglycemic ADJ O
hormone NOUN O
( PUNCT O
CHH PROPN B-AC
) PUNCT O
, PUNCT O
retinoid NOUN O
X NOUN O
receptor NOUN O
and CCONJ O
ecdysteroid NOUN B-LF
receptor NOUN I-LF
( PUNCT O
EcR PROPN B-AC
) PUNCT O
[ PUNCT O
4–8 NUM O
] PUNCT O
, PUNCT O
cuticle NOUN O
- PUNCT O
related VERB O
enzymes NOUN O
( PUNCT O
chitinases NOUN O
, PUNCT O
chitin NOUN O
deacetylase NOUN O
, PUNCT O
and CCONJ O
chitin NOUN O
synthase NOUN O
) PUNCT O
[ PUNCT O
9–11 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
structural ADJ O
proteins NOUN O
of ADP O
the DET O
cuticle NOUN O
[ PUNCT O
12 NUM O
, PUNCT O
13 NUM O
] PUNCT O
. PUNCT O

Right INTJ O
, PUNCT O
average ADJ O
time NOUN O
- PUNCT O
point NOUN O
variability NOUN O
for ADP O
the DET O
different ADJ O
temporal ADJ O
jitter NOUN O
levels NOUN O
. PUNCT O
( PUNCT O
E NOUN O
- PUNCT O
H NOUN O
) PUNCT O
Same ADJ O
as ADP O
( PUNCT O
A NOUN O
– SYM O
D NOUN O
) PUNCT O
, PUNCT O
for ADP O
second ADJ O
simulation NOUN O
, PUNCT O
using VERB O
a DET O
different ADJ O
IRF PROPN B-AC
. PUNCT O
arb NOUN O
. PUNCT O
, PUNCT O
arbitrary ADJ O
; PUNCT O
IRF PROPN B-AC
, PUNCT O
impulse NOUN B-LF
response NOUN I-LF
function NOUN I-LF
; PUNCT O
std NOUN B-AC
, PUNCT O
standard ADJ B-LF
deviation NOUN I-LF
. PUNCT O

IB5 PROPN B-AC
, PUNCT O
intrabody NOUN B-LF
5 NUM I-LF
; PUNCT O
MEF PROPN B-AC
, PUNCT O
Mouse PROPN B-LF
Embryonic PROPN I-LF
Fibroblast PROPN I-LF
; PUNCT O
PKM2 PROPN O
, PUNCT O
pyruvate NOUN O
kinase NOUN O
isoform NOUN O
M2 PROPN O
; PUNCT O
scFv PROPN B-AC
, PUNCT O
single ADJ B-LF
- PUNCT I-LF
chain NOUN I-LF
variable NOUN I-LF
fragment NOUN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF

The DET O
novel ADJ O
findings NOUN O
in ADP O
the DET O
study NOUN O
was AUX O
the DET O
identification NOUN O
of ADP O
13 NUM O
additional ADJ O
proteins NOUN O
with ADP O
an DET O
independent ADJ O
association NOUN O
to ADP O
CV PROPN B-AC
mortality NOUN O
in ADP O
patients NOUN O
with ADP O
chronic ADJ O
CHD PROPN B-AC
, PUNCT O
i.e. X O
, PUNCT O
TIM-1 PROPN B-AC
, PUNCT O
REN PROPN O
, PUNCT O
OPG PROPN B-AC
, PUNCT O
sST2 PROPN B-AC
, PUNCT O
TRAIL PROPN B-AC
- PUNCT B-AC
R2 PROPN B-AC
, PUNCT O
CA-125 PROPN B-AC
, PUNCT O
BNP PROPN B-AC
, PUNCT O
HGF PROPN B-AC
, PUNCT O
SPON-1 PROPN O
, PUNCT O
FGF-23 PROPN B-AC
, PUNCT O
CHI3L1 PROPN B-AC
, PUNCT O
TNF PROPN B-AC
- PUNCT B-AC
R1 PROPN B-AC
, PUNCT O
and CCONJ O
AM PROPN B-AC
. PUNCT O
The DET O
results NOUN O
indicate VERB O
that SCONJ O
myocardial ADJ O
strain NOUN O
– PUNCT O
dysfunction NOUN O
– PUNCT O
hypertrophy NOUN O
– PUNCT O
fibrosis NOUN O
( PUNCT O
NTproBNP PROPN B-AC
, PUNCT O
BNP PROPN B-AC
, PUNCT O
sST-2 PROPN O
, PUNCT O
SPON-1 PROPN O
, PUNCT O
and CCONJ O
CA-125 PROPN B-AC
) PUNCT O
, PUNCT O
myocyte NOUN O
death NOUN O
and CCONJ O
apoptosis NOUN O
( PUNCT O
cTnT PROPN B-AC
- PUNCT B-AC
hs PROPN B-AC
, PUNCT O
TNF PROPN B-AC
- PUNCT B-AC
R1 PROPN B-AC
, PUNCT O
and CCONJ O
TRAIL PROPN B-AC
- PUNCT B-AC
R2 PROPN B-AC
) PUNCT O
, PUNCT O
kidney NOUN O
injury NOUN O
( PUNCT O
Cys PROPN B-AC
- PUNCT B-AC
C PROPN B-AC
, PUNCT O
FGF-23 PROPN B-AC
, PUNCT O
and CCONJ O
TIM-1 PROPN B-AC
) PUNCT O
, PUNCT O
hemodynamic ADJ O
stress NOUN O
, PUNCT O
renin NOUN B-LF
– PUNCT I-LF
angiotensin NOUN I-LF
system NOUN I-LF
( PUNCT O
RAS PROPN B-AC
) PUNCT O
activation NOUN O
( PUNCT O
REN PROPN O
and CCONJ O
AM PROPN B-AC
) PUNCT O
, PUNCT O
oxidative ADJ O
stress NOUN O
and CCONJ O
inflammation NOUN O
( PUNCT O
GDF-15 PROPN B-AC
, PUNCT O
IL-6 PROPN B-AC
, PUNCT O
OPG PROPN B-AC
, PUNCT O
and CCONJ O
CHI3L1 PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
angiogenesis NOUN O
and CCONJ O
vascular ADJ O
cell NOUN O
proliferation NOUN O
( PUNCT O
HGF PROPN B-AC
) PUNCT O
are AUX O
important ADJ O
mechanisms NOUN O
associated VERB O
with ADP O
CV PROPN B-AC
death NOUN O
in ADP O
patients NOUN O
with ADP O
chronic ADJ O
CHD PROPN B-AC
( PUNCT O
Fig PROPN O
5 NUM O
) PUNCT O
. PUNCT O

HIV PROPN O
infection NOUN O
, PUNCT O
in ADP O
particular ADJ O
, PUNCT O
is AUX O
known VERB O
to ADP O
be AUX O
associated VERB O
with ADP O
higher ADJ O
risk NOUN O
of ADP O
TB PROPN B-AC
and CCONJ O
increases VERB O
the DET O
lifetime NOUN O
risk NOUN O
of ADP O
progression NOUN O
from ADP O
Mycobacterium NOUN O
tuberculosis NOUN B-LF
infection NOUN O
to ADP O
active ADJ O
disease NOUN O
[ PUNCT O
22 NUM O
] PUNCT O
. PUNCT O

National PROPN B-LF
Inpatient PROPN I-LF
Sample PROPN I-LF
( PUNCT O
NIS PROPN B-AC
) PUNCT O
data NOUN O
from ADP O
1998–2016 NUM O
. PUNCT O

STEMI PROPN O
, PUNCT O
ST NOUN O
- PUNCT O
segment NOUN O
elevation NOUN O
myocardial ADJ O
infarction NOUN O
; PUNCT O
CABG PROPN O
, PUNCT O
coronary ADJ O
artery NOUN O
bypass NOUN O
graft NOUN O
; PUNCT O
IRA PROPN B-AC
, PUNCT O
infarct NOUN B-LF
- PUNCT I-LF
related VERB I-LF
artery NOUN I-LF
; PUNCT O
PCI PROPN B-AC
, PUNCT O
percutaneous ADJ B-LF
coronary ADJ I-LF
intervention NOUN I-LF
; PUNCT O
LVEF PROPN B-AC
, PUNCT O
left VERB B-LF
ventricular ADJ I-LF
ejection NOUN I-LF
fraction NOUN I-LF
; PUNCT O
CAG PROPN O
, PUNCT O
coronary ADJ O
angiography NOUN O
; PUNCT O
POBA PROPN O
, PUNCT O
plain ADJ O
old ADJ O
balloon NOUN O
angioplasty NOUN O
. PUNCT O

The DET O
purpose NOUN O
of ADP O
this DET O
review NOUN O
was AUX O
to PART O
summarize VERB O
the DET O
published VERB O
literature NOUN O
on ADP O
the DET O
association NOUN O
of ADP O
childhood NOUN O
, PUNCT O
adulthood NOUN O
and CCONJ O
life NOUN O
course NOUN O
socio ADJ B-LF
- ADJ I-LF
economic ADJ I-LF
status NOUN I-LF
( PUNCT O
SES PROPN B-AC
) PUNCT O
with ADP O
obesity NOUN O
between ADP O
January PROPN O
1990 NUM O
and CCONJ O
June PROPN O
2015 NUM O
. PUNCT O

The DET O
Alzheimer PROPN B-LF
's PART I-LF
Disease PROPN I-LF
Anti PROPN I-LF
- PROPN I-LF
inflammatory ADJ I-LF
Prevention PROPN I-LF
Trial PROPN I-LF
( PUNCT O
ADAPT PROPN B-AC
) PUNCT O
was AUX O
designed VERB O
to PART O
evaluate VERB O
the DET O
conventional ADJ O
NSAID PROPN B-AC
naproxen NOUN O
sodium NOUN O
and CCONJ O
the DET O
selective ADJ O
COX-2 NOUN B-AC
inhibitor NOUN O
celecoxib NOUN O
for ADP O
primary ADJ O
prevention NOUN O
of ADP O
Alzheimer PROPN B-LF
's PART I-LF
dementia NOUN I-LF
( PUNCT O
AD NOUN B-AC
) PUNCT O
. PUNCT O
On ADP O
17 NUM O
December PROPN O
2004 NUM O
, PUNCT O
after SCONJ O
the DET O
Adenoma PROPN O
Prevention PROPN O
with ADP O
Celecoxib PROPN O
( PUNCT O
APC PROPN B-AC
) PUNCT O
trial NOUN O
reported VERB O
increased VERB O
cardiovascular ADJ O
risks NOUN O
with ADP O
celecoxib NOUN O
, PUNCT O
the DET O
ADAPT PROPN B-AC
Steering PROPN O
Committee PROPN O
suspended VERB O
treatment NOUN O
and CCONJ O
enrollment NOUN O
. PUNCT O

The DET O
updated VERB O
Position PROPN O
Statement PROPN O
[ X O
3 NUM O
] X O
by ADP O
the DET O
American PROPN B-LF
Diabetes PROPN I-LF
Association PROPN I-LF
( PUNCT O
ADA PROPN B-AC
) PUNCT O
and CCONJ O
the DET O
European PROPN B-LF
Association PROPN I-LF
for ADP I-LF
the DET I-LF
Study PROPN I-LF
of ADP I-LF
Diabetes PROPN I-LF
( PUNCT O
EASD PROPN B-AC
) PUNCT O
endorsed VERB O
the DET O
addition NOUN O
of ADP O
one NUM O
of ADP O
the DET O
following ADJ O
glucose NOUN O
- PUNCT O
lowering VERB O
medications NOUN O
as ADP O
a DET O
third ADJ O
- PUNCT O
line NOUN O
option NOUN O
when SCONJ O
optimal ADJ O
glycemic ADJ O
control NOUN O
is AUX O
not PART O
achieved VERB O
after ADP O
3 NUM O
months NOUN O
of ADP O
dual ADJ O
therapy NOUN O
: PUNCT O
thiazolidinedione NOUN B-LF
( PUNCT O
TZD PROPN B-AC
) PUNCT O
, PUNCT O
dipeptidyl NOUN O
peptidase‐4 NOUN O
inhibitors NOUN O
( PUNCT O
DPP4i PROPN B-AC
) PUNCT O
, PUNCT O
sodium‐glucose NOUN B-LF
co‐transporter‐2 NOUN I-LF
( PUNCT O
SGLT2 PROPN B-AC
) PUNCT O
inhibitors NOUN O
, PUNCT O
glucagon‐like NOUN B-LF
peptide‐1 NOUN I-LF
receptor NOUN I-LF
agonists NOUN I-LF
( PUNCT O
GLP1 PROPN B-AC
- PUNCT B-AC
RAs PROPN O
) PUNCT O
, PUNCT O
or CCONJ O
basal ADJ O
insulin NOUN O
regimen NOUN O
. PUNCT O

This DET O
result NOUN O
suggests VERB O
that SCONJ O
trace NOUN B-LF
quantities NOUN I-LF
of ADP I-LF
organic ADJ I-LF
matter NOUN I-LF
( PUNCT O
TQOM PROPN B-AC
; PUNCT O
phthalates NOUN O
, PUNCT O
SPNES PROPN B-AC
, PUNCT O
amine NOUN O
compounds NOUN O
, PUNCT O
and CCONJ O
hydrocarbon NOUN O
) PUNCT O
in ADP O
the DET O
air NOUN O
are AUX O
absorbed VERB O
in ADP O
concrete ADJ O
structures NOUN O
by ADP O
the DET O
concrete ADJ O
respiratory ADJ O
action NOUN O
. PUNCT O

Among ADP O
PWID PROPN O
in ADP O
New PROPN B-LF
South PROPN I-LF
Wales PROPN I-LF
( PUNCT O
NSW PROPN B-AC
) PUNCT O
prisons NOUN O
, PUNCT O
Australia PROPN O
, PUNCT O
the DET O
length NOUN B-LF
of ADP I-LF
stay NOUN I-LF
( PUNCT O
LOS NOUN B-AC
) PUNCT O
before ADP O
being AUX O
released VERB O
, PUNCT O
is AUX O
typically ADV O
short ADJ O
( PUNCT O
average ADJ O
7–9 NUM O
months NOUN O
) PUNCT O
. PUNCT O

One NUM O
main ADJ O
source NOUN O
of ADP O
airborne ADJ O
particulate NOUN B-LF
matter NOUN I-LF
( PUNCT O
PM NOUN B-AC
) PUNCT O
in ADP O
urban ADJ O
regions NOUN O
are AUX O
motor NOUN O
vehicle NOUN O
emissions NOUN O
, PUNCT O
which PRON O
can AUX O
also ADV O
contain VERB O
various ADJ O
metals NOUN O
and CCONJ O
toxic ADJ O
compounds NOUN O
such ADJ O
as ADP O
mutagenic ADJ O
polyaromatic ADJ O
hydrocarbons NOUN O
( PUNCT O
PAH NOUN O
) PUNCT O
[ PUNCT O
2 NUM O
] PUNCT O
. PUNCT O

Statins NOUN O
showed VERB O
mixed ADJ O
results NOUN O
in ADP O
heart NOUN B-LF
failure NOUN I-LF
( PUNCT O
HF PROPN B-AC
) PUNCT O
patients NOUN O
. PUNCT O

Globally ADV O
, PUNCT O
about ADV O
800,000 NUM O
people NOUN O
die VERB O
from ADP O
suicide NOUN O
every DET O
year NOUN O
and CCONJ O
79 NUM O
% NOUN O
of ADP O
these DET O
deaths NOUN O
occur VERB O
in ADP O
low- ADJ B-LF
and CCONJ I-LF
middle ADJ I-LF
- PUNCT I-LF
income NOUN I-LF
countries NOUN I-LF
( PUNCT O
LMICs PROPN B-AC
) PUNCT O
[ PUNCT O
5 NUM O
] PUNCT O
. PUNCT O

An DET O
adapted ADJ O
protocol NOUN O
was AUX O
applied VERB O
following VERB O
the DET O
Tobacco PROPN B-LF
Smoke PROPN I-LF
Particles PROPN I-LF
and CCONJ I-LF
Indoor PROPN I-LF
Air PROPN I-LF
Quality PROPN I-LF
( PUNCT O
ToPIQ PROPN B-AC
) PUNCT O
studies NOUN O
[ PUNCT O
31 NUM O
] PUNCT O
. PUNCT O

G. PROPN O
) PUNCT O
undertook VERB O
a DET O
detailed ADJ O
hand NOUN O
search NOUN O
focusing VERB O
on ADP O
the DET O
Cochrane PROPN O
Database PROPN O
of ADP O
Systematic PROPN O
Reviews PROPN O
and CCONJ O
the DET O
Database PROPN B-LF
of ADP I-LF
Abstracts PROPN I-LF
of ADP I-LF
Reviews PROPN I-LF
of ADP I-LF
Effects PROPN I-LF
( PUNCT O
DARE PROPN B-AC
) PUNCT O
to PART O
identify VERB O
systematic ADJ O
reviews NOUN O
that PRON O
had AUX O
evaluated VERB O
adverse ADJ O
effects NOUN O
as ADP O
a DET O
primary ADJ O
outcome NOUN O
. PUNCT O

In ADP O
the DET O
standard ADJ O
- PUNCT O
of ADP O
- PUNCT O
care NOUN O
arm NOUN O
, PUNCT O
CHWs PROPN B-AC
visited VERB O
women NOUN O
enrolled VERB O
in ADP O
prevention NOUN B-LF
of ADP I-LF
mother NOUN I-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
child NOUN I-LF
HIV PROPN I-LF
transmission NOUN I-LF
( PUNCT O
PMTCT PROPN B-AC
) PUNCT O
care NOUN O
and CCONJ O
provided VERB O
information NOUN O
and CCONJ O
counseling NOUN O
. PUNCT O

ART PROPN B-AC
, PUNCT O
antiretroviral ADJ B-LF
therapy NOUN I-LF
; PUNCT O
CD4 PROPN B-AC
, PUNCT O
cluster NOUN B-LF
of ADP I-LF
differentiation NOUN I-LF
4 NUM I-LF
; PUNCT O
RUSF PROPN B-AC
, PUNCT O
ready ADJ B-LF
- PUNCT I-LF
to PART I-LF
- PUNCT I-LF
use VERB I-LF
supplementary ADJ I-LF
food NOUN I-LF
. PUNCT O

For ADP O
each DET O
model NOUN O
, PUNCT O
bivariable ADJ O
analysis NOUN O
with ADP O
( PUNCT O
crude ADJ B-LF
odds NOUN I-LF
ratio NOUN I-LF
[ PUNCT O
COR NOUN B-AC
] PUNCT O
) PUNCT O
and CCONJ O
multivariable ADJ O
analysis NOUN O
( PUNCT O
adjusted VERB B-LF
odds NOUN I-LF
ratio NOUN I-LF
[ PUNCT O
AOR NOUN B-AC
] PUNCT O
) PUNCT O
was AUX O
used VERB O
. PUNCT O

However ADV O
, PUNCT O
association NOUN O
between ADP O
NLR PROPN B-AC
elevation NOUN O
and CCONJ O
survival NOUN O
outcome NOUN O
in ADP O
patients NOUN O
with ADP O
colorectal ADJ B-LF
liver NOUN I-LF
metastasis NOUN I-LF
( PUNCT O
CRLM PROPN B-AC
) PUNCT O
remains VERB O
controversial ADJ O
. PUNCT O

IMD PROPN B-AC
, PUNCT O
index NOUN B-LF
of ADP I-LF
multiple ADJ I-LF
deprivation NOUN I-LF
; PUNCT O
SDS PROPN B-AC
, PUNCT O
standard ADJ B-LF
deviation NOUN I-LF
score NOUN I-LF
. PUNCT O

As ADP O
a DET O
quantitative ADJ O
indicator NOUN O
of ADP O
hepatocellular ADJ O
damage NOUN O
, PUNCT O
circulating VERB O
levels NOUN O
of ADP O
alanine ADJ B-LF
aminotransferase NOUN I-LF
( PUNCT O
ALT PROPN B-AC
) PUNCT O
were AUX O
measured VERB O
. PUNCT O

GDP PROPN B-AC
, PUNCT O
gross ADJ B-LF
domestic ADJ I-LF
product NOUN I-LF
. PUNCT O

ADME NOUN B-AC
( PUNCT O
absorption NOUN B-LF
, PUNCT I-LF
distribution NOUN I-LF
, PUNCT I-LF
metabolism NOUN I-LF
, PUNCT I-LF
excretion NOUN I-LF
) PUNCT O
and CCONJ O
toxicity NOUN O
properties NOUN O
of ADP O
the DET O
obtained VERB O
compounds NOUN O
were AUX O
carried VERB O
out ADP O
to PART O
evaluate VERB O
the DET O
pharmacological ADJ O
properties NOUN O
of ADP O
these DET O
selected VERB O
compounds NOUN O
. PUNCT O

Cohesins NOUN O
mutated VERB O
in ADP O
the DET O
Hinge PROPN O
or CCONJ O
Loop1 PROPN O
regions NOUN O
of ADP O
Smc1 PROPN O
bind VERB O
chromatin NOUN O
by ADP O
a DET O
mechanism NOUN O
similar ADJ O
to PART O
wild ADJ O
- PUNCT O
type NOUN O
cohesin NOUN O
, PUNCT O
but CCONJ O
fail VERB O
to PART O
enrich VERB O
at ADP O
cohesin NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
regions NOUN I-LF
( PUNCT O
CARs NOUN B-AC
) PUNCT O
and CCONJ O
pericentric ADJ O
regions NOUN O
. PUNCT O

In ADP O
line NOUN O
with ADP O
our PRON O
results NOUN O
, PUNCT O
animal NOUN O
studies NOUN O
and CCONJ O
studies NOUN O
with ADP O
smaller ADJ O
subsets NOUN O
of ADP O
patients NOUN O
with ADP O
suspected VERB O
pulmonary ADJ B-LF
emboli NOUN I-LF
have AUX O
reported VERB O
an DET O
increased VERB O
sensitivity NOUN O
of ADP O
DECT NOUN B-AC
vessel NOUN O
reconstructions NOUN O
for ADP O
diagnosis NOUN O
of ADP O
PE NOUN B-AC
, PUNCT O
in ADP O
particular ADJ O
for ADP O
peripheral ADJ O
emboli NOUN O
[ PUNCT O
8 NUM O
, PUNCT O
11 NUM O
, PUNCT O
12 NUM O
, PUNCT O
21 NUM O
, PUNCT O
22 NUM O
] PUNCT O
. PUNCT O

Unweighted ADJ O
UniFrac PROPN O
distance NOUN O
metrics NOUN O
[ X O
45 NUM O
] X O
were AUX O
generated VERB O
and CCONJ O
principle ADJ B-LF
coordinate NOUN I-LF
analysis NOUN I-LF
( PUNCT O
PCoA NOUN B-AC
) PUNCT O
was AUX O
used VERB O
to PART O
visualize VERB O
the DET O
metrics NOUN O
. PUNCT O

Funisitis NOUN O
( PUNCT O
inflammation NOUN O
in ADP O
UC PROPN B-AC
) PUNCT O
defined VERB O
in ADP O
the DET O
presence NOUN O
of ADP O
neutrophil NOUN O
infiltration NOUN O
into ADP O
the DET O
umbilical ADJ O
vessels NOUN O
with ADP O
or CCONJ O
without ADP O
the DET O
involvement NOUN O
of ADP O
Wharton PROPN B-LF
’s PART I-LF
Jelly PROPN I-LF
( PUNCT O
WJ PROPN B-AC
) PUNCT O
in ADP O
fetus NOUN O
is AUX O
known VERB O
to PART O
be AUX O
the DET O
histologic ADJ O
hallmark NOUN O
of ADP O
systemic ADJ O
fetal ADJ O
inflammation NOUN O
, PUNCT O
fetal ADJ B-LF
inflammatory ADJ I-LF
response NOUN I-LF
syndrome NOUN I-LF
( PUNCT O
FIRS PROPN B-AC
) PUNCT O
[ PUNCT O
6–8 NUM O
] PUNCT O
. PUNCT O

The DET O
registers NOUN O
used VERB O
in ADP O
the DET O
current ADJ O
study NOUN O
are AUX O
listed VERB O
as ADP O
follows VERB O
: PUNCT O
The DET O
Medical PROPN O
Birth PROPN O
Register PROPN O
covers VERB O
nearly ADV O
all DET O
deliveries NOUN O
in ADP O
Sweden PROPN O
since SCONJ O
1973 NUM O
[ PUNCT O
9 NUM O
] PUNCT O
; PUNCT O
The DET O
Total PROPN O
Population PROPN O
Register PROPN O
was AUX O
established VERB O
in ADP O
1968 NUM O
and CCONJ O
contains VERB O
data NOUN O
on ADP O
sex NOUN O
, PUNCT O
birth NOUN O
, PUNCT O
death NOUN O
, PUNCT O
migration NOUN O
, PUNCT O
and CCONJ O
family NOUN O
relationship NOUN O
for ADP O
Swedish ADJ O
residents NOUN O
who PRON O
were AUX O
born VERB O
since SCONJ O
1932 NUM O
[ PUNCT O
10 NUM O
] PUNCT O
; PUNCT O
The DET O
Multi PROPN O
- PROPN O
Generation PROPN O
Register PROPN O
, PUNCT O
as ADP O
part NOUN O
of ADP O
the DET O
Total PROPN O
Population PROPN O
Register PROPN O
, PUNCT O
links VERB O
individuals NOUN O
born VERB O
since SCONJ O
1932 NUM O
and CCONJ O
registered VERB O
as ADP O
living VERB O
in ADP O
Sweden PROPN O
since SCONJ O
1961 NUM O
to ADP O
their PRON O
biological ADJ O
parents NOUN O
[ PUNCT O
11 NUM O
] PUNCT O
; PUNCT O
The DET O
longitudinal ADJ B-LF
integration NOUN I-LF
database NOUN I-LF
for ADP I-LF
health NOUN I-LF
insurance NOUN I-LF
and CCONJ I-LF
labor NOUN I-LF
market NOUN I-LF
studies NOUN I-LF
( PUNCT O
LISA PROPN B-AC
) PUNCT O
launched VERB O
in ADP O
1990 NUM O
and CCONJ O
contains VERB O
annually ADV O
updated VERB O
data NOUN O
on ADP O
socioeconomic ADJ B-LF
status NOUN I-LF
( PUNCT O
SES PROPN B-AC
) PUNCT O
such ADJ O
as ADP O
education NOUN O
, PUNCT O
civil ADJ O
status NOUN O
, PUNCT O
unemployment NOUN O
, PUNCT O
social ADJ O
benefits NOUN O
, PUNCT O
family NOUN O
income NOUN O
, PUNCT O
and CCONJ O
many ADJ O
other ADJ O
variables NOUN O
for ADP O
all DET O
Swedish ADJ O
residents NOUN O
aged VERB O
16 NUM O
years NOUN O
or CCONJ O
older ADJ O
[ PUNCT O
12 NUM O
] PUNCT O
; PUNCT O
The DET O
National PROPN O
Patient PROPN O
Register PROPN O
covers VERB O
inpatient NOUN O
care NOUN O
since SCONJ O
1964 NUM O
( PUNCT O
psychiatric ADJ O
care NOUN O
since SCONJ O
1973 NUM O
) PUNCT O
and CCONJ O
outpatient NOUN O
visits NOUN O
to ADP O
specialty NOUN O
care NOUN O
since SCONJ O
2001 NUM O
, PUNCT O
with ADP O
a DET O
PPV NOUN B-AC
of ADP O
85 NUM O
% NOUN O
to ADP O
95 NUM O
% NOUN O
for ADP O
most ADJ O
disorders NOUN O
[ PUNCT O
13 NUM O
] PUNCT O
; PUNCT O
The DET O
Prescribed PROPN O
Drug PROPN O
Register PROPN O
contains VERB O
data NOUN O
on ADP O
all DET O
prescribed VERB O
medications NOUN O
dispensed VERB O
at ADP O
pharmacies NOUN O
in ADP O
Sweden PROPN O
since SCONJ O
July PROPN O
2005 NUM O
[ PUNCT O
14 NUM O
] PUNCT O
; PUNCT O
Active ADJ O
ingredients NOUN O
of ADP O
medications NOUN O
are AUX O
coded VERB O
according VERB O
to ADP O
the DET O
anatomical ADJ B-LF
therapeutic ADJ I-LF
chemical NOUN I-LF
( PUNCT O
ATC PROPN B-AC
) PUNCT O
classification NOUN O
system NOUN O
[ PUNCT O
14 NUM O
] PUNCT O
; PUNCT O
The DET O
National PROPN O
Crime PROPN O
Register PROPN O
provides VERB O
data NOUN O
on ADP O
violent ADJ O
and CCONJ O
nonviolent ADJ O
crime NOUN O
convictions NOUN O
since SCONJ O
1973 NUM O
[ PUNCT O
15 NUM O
] PUNCT O
. PUNCT O

‡Reported VERB O
by ADP O
women NOUN O
through ADP O
audio ADJ B-LF
computer NOUN I-LF
- PUNCT I-LF
assisted VERB I-LF
self NOUN I-LF
- PUNCT I-LF
interview NOUN I-LF
( PUNCT O
ACASI PROPN B-AC
) PUNCT O
4 NUM O
weeks NOUN O
after ADP O
enrolment NOUN O
. PUNCT O

Using VERB O
insulin NOUN O
- PUNCT O
resistant ADJ O
mice NOUN O
deficient ADJ O
for ADP O
insulin NOUN B-LF
receptor NOUN I-LF
substrate NOUN I-LF
2 NUM I-LF
( PUNCT O
Irs2 PROPN B-AC
) PUNCT O
, PUNCT O
we PRON O
highlight VERB O
dramatic ADJ O
impairment NOUN O
of ADP O
proregenerative ADJ O
fibroblast NOUN B-LF
growth NOUN I-LF
factor NOUN I-LF
7 NUM I-LF
( PUNCT O
Fgf7 PROPN B-AC
) PUNCT O
signaling NOUN O
between ADP O
stromal ADJ O
niche NOUN O
cells NOUN O
and CCONJ O
LPCs NOUN B-AC
during ADP O
chronic ADJ O
injury NOUN O
. PUNCT O

Estimating VERB O
kidney NOUN O
glomerular ADJ B-LF
filtration NOUN I-LF
rate NOUN I-LF
( PUNCT O
GFR NOUN B-AC
) PUNCT O
is AUX O
of ADP O
utmost ADJ O
importance NOUN O
in ADP O
many ADJ O
clinical ADJ O
conditions NOUN O
. PUNCT O

Transfusion NOUN O
- PUNCT O
transmissible ADJ O
viral ADJ O
infections NOUN O
, PUNCT O
such ADJ O
as ADP O
hepatitis NOUN B-LF
C PROPN I-LF
virus NOUN I-LF
( PUNCT O
HCV PROPN B-AC
) PUNCT O
, PUNCT O
hepatitis NOUN B-LF
B PROPN I-LF
virus NOUN I-LF
( PUNCT O
HBV PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
human ADJ B-LF
immunodeficiency NOUN I-LF
virus NOUN I-LF
( PUNCT O
HIV PROPN B-AC
) PUNCT O
, PUNCT O
remain VERB O
a DET O
major ADJ O
public ADJ O
health NOUN O
problem NOUN O
in ADP O
developing VERB O
countries NOUN O
. PUNCT O

The DET O
alpha NOUN O
- PUNCT O
herpesvirinae NOUN O
subfamily NOUN O
includes VERB O
pseudorabies NOUN B-LF
virus NOUN I-LF
( PUNCT O
PRV PROPN B-AC
) PUNCT O
, PUNCT O
varicella NOUN O
- PUNCT O
zoster NOUN O
virus NOUN O
, PUNCT O
and CCONJ O
herpes NOUN B-LF
simplex NOUN I-LF
virus NOUN I-LF
type NOUN I-LF
1 NUM I-LF
and CCONJ O
type NOUN O
2 NUM O
( PUNCT O
HSV-1 NOUN B-AC
and CCONJ O
HSV-2 PROPN O
) PUNCT O
. PUNCT O

In ADP O
2016 NUM O
the DET O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT O
WHO PROPN B-AC
) PUNCT O
released VERB O
their PRON O
first ADJ O
global ADJ B-LF
health NOUN I-LF
sector NOUN I-LF
strategy NOUN I-LF
( PUNCT O
GHSS PROPN B-AC
) PUNCT O
on ADP O
viral ADJ O
hepatitis[1 NOUN O
] PUNCT O
. PUNCT O

BMDM PROPN B-AC
, PUNCT O
bone NOUN B-LF
marrow NOUN I-LF
– PUNCT I-LF
derived VERB I-LF
macrophage NOUN I-LF
; PUNCT O
DEX PROPN O
, PUNCT O
dexamethasone NOUN O
; PUNCT O
FACS PROPN O
, PUNCT O
fluorescence NOUN O
- PUNCT O
activated VERB O
cell NOUN O
sorting NOUN O
. PUNCT O

Nasopharyngeal ADJ B-LF
carcinoma NOUN I-LF
( PUNCT O
NPC PROPN B-AC
) PUNCT O
is AUX O
a DET O
rare ADJ O
disease NOUN O
in ADP O
most ADJ O
parts NOUN O
of ADP O
the DET O
world NOUN O
. PUNCT O

Expression NOUN O
values NOUN O
for ADP O
each DET O
lncRNA NOUN B-AC
are AUX O
normalized VERB O
to ADP O
that PRON O
of ADP O
the DET O
gene NOUN O
encoding VERB O
actin NOUN O
. PUNCT O
( PUNCT O
D NOUN O
) PUNCT O
Large ADJ O
overlap NOUN O
in ADP O
differentially ADV O
expressed VERB O
lncRNAs NOUN B-AC
between ADP O
GBMs PROPN B-AC
and CCONJ O
LGGs NOUN B-AC
. PUNCT O
GBM NOUN B-AC
, PUNCT O
glioblastoma NOUN B-LF
multiforme ADJ I-LF
; PUNCT O
LGG NOUN B-AC
, PUNCT O
lower ADJ B-LF
grade NOUN I-LF
glioma NOUN I-LF
; PUNCT O
lncRNA NOUN B-AC
, PUNCT O
long ADJ B-LF
noncoding VERB I-LF
RNA NOUN I-LF
. PUNCT O

Line556 NOUN O
: PUNCT O
“ PUNCT O
B. NOUN O
proteoclastus NOUN O
in ADP O
the DET O
M2I PROPN B-AC
group NOUN O
in ADP O
in ADP O
vivo ADJ O
increased VERB O
, PUNCT O
This PRON O
indicates VERB O
low ADJ O
concentrations NOUN O
of ADP O
PSM PROPN B-AC
“ PUNCT O
--- PUNCT O
I PRON O
think VERB O
Control PROPN B-LF
non ADJ I-LF
- ADJ I-LF
infected ADJ I-LF
( PUNCT O
CN PROPN B-AC
) PUNCT O
and CCONJ O
Control PROPN B-LF
infected ADJ I-LF
( PUNCT O
CI PROPN B-AC
) PUNCT O
low ADJ O
concentrations NOUN O
of ADP O
PSM PROPN B-AC
more ADJ O
than ADP O
M2I PROPN B-AC
, PUNCT O
please INTJ O
check VERB O

A DET O
relationship NOUN O
between ADP O
anxiety NOUN O
- PUNCT O
like ADJ O
behaviour NOUN O
and CCONJ O
dysbiosis NOUN O
was AUX O
demonstrated VERB O
by ADP O
administering VERB O
a DET O
fecal ADJ B-LF
microbiota NOUN I-LF
transplant NOUN I-LF
( PUNCT O
FMT PROPN B-AC
) PUNCT O
at ADP O
the DET O
time NOUN O
of ADP O
injury NOUN O
and CCONJ O
for ADP O
two NUM O
consecutive ADJ O
days NOUN O
after ADP O
SCI PROPN B-AC
. PUNCT O
The DET O
FMT PROPN B-AC
attenuated VERB O
gut NOUN O
dysbiosis NOUN O
and CCONJ O
alleviated VERB O
SCI PROPN B-AC
- PUNCT O
induced VERB O
anxiety NOUN O
- PUNCT O
like ADJ O
behaviour NOUN O
. PUNCT O

Our PRON O
preliminary ADJ O
study NOUN O
on ADP O
a DET O
Ptprz PROPN O
- PUNCT O
knockout NOUN B-LF
( PUNCT O
KO PROPN B-AC
) PUNCT O
mouse NOUN O
cohort NOUN O
that PRON O
was AUX O
backcrossed VERB O
for ADP O
four NUM O
generations NOUN O
( PUNCT O
93.7 NUM O
% NOUN O
homogeneity NOUN O
with ADP O
the DET O
C57BL6J PROPN O
genetic ADJ O
background NOUN O
) PUNCT O
revealed VERB O
altered VERB O
responsiveness NOUN O
to ADP O
novelty NOUN O
and CCONJ O
METH NOUN B-AC
, PUNCT O
and CCONJ O
we PRON O
presented VERB O
these DET O
results NOUN O
at ADP O
the DET O
annual ADJ O
meeting NOUN O
of ADP O
the DET O
Society PROPN O
of ADP O
Neuroscience[14 PROPN O
] PUNCT O
: PUNCT O
The DET O
knockout NOUN B-LF
line NOUN O
was AUX O
originally ADV O
generated VERB O
by ADP O
gene NOUN O
targeting NOUN O
in ADP O
129X1 PROPN O
/ SYM O
SvJ PROPN O
ES PROPN O
cells NOUN O
[ PUNCT O
15 NUM O
] PUNCT O
. PUNCT O

In ADP O
fission NOUN O
yeast NOUN O
, PUNCT O
the DET O
anaphase NOUN B-LF
- PUNCT I-LF
promoting VERB I-LF
complex NOUN I-LF
/ SYM I-LF
cyclosome NOUN I-LF
( PUNCT O
APC PROPN B-AC
/ SYM B-AC
C PROPN B-AC
) PUNCT O
and CCONJ O
the DET O
septation NOUN B-LF
initiation NOUN I-LF
network NOUN I-LF
( PUNCT O
SIN PROPN B-AC
) PUNCT O
, PUNCT O
a DET O
spindle NOUN B-LF
pole NOUN I-LF
body NOUN I-LF
( PUNCT O
SPB)–associated PROPN B-AC
GTPase NOUN O
- PUNCT O
driven VERB O
signaling NOUN O
cascade NOUN O
, PUNCT O
function VERB O
sequentially ADV O
to PART O
ensure VERB O
proper ADJ O
coordination NOUN O
of ADP O
mitosis NOUN O
and CCONJ O
cytokinesis NOUN O
. PUNCT O

mGFR PROPN B-AC
, PUNCT O
measured VERB B-LF
glomerular ADJ I-LF
filtration NOUN I-LF
rate NOUN I-LF
in ADP O
mL NOUN O
/ SYM O
min/1.73m2 NUM O
; PUNCT O
SD NOUN O
, PUNCT O
standard ADJ O
deviation NOUN O
; PUNCT O
IQR NOUN B-AC
, PUNCT O
interquartile ADJ B-LF
range NOUN I-LF
; PUNCT O
UACR PROPN O
, PUNCT O
urinary ADJ O
albumin NOUN O
- PUNCT O
creatinine NOUN O
ratio NOUN O
; PUNCT O
HLA PROPN O
, PUNCT O
Human PROPN O
leukocyte NOUN O
antigen NOUN O
. PUNCT O

MIC PROPN B-AC
, PUNCT O
minimum ADJ B-LF
inhibitory ADJ I-LF
concentration NOUN I-LF
. PUNCT O

Although SCONJ O
this DET O
post ADJ B-LF
- ADJ I-LF
translational ADJ I-LF
oscillator NOUN I-LF
( PUNCT O
PTO PROPN B-AC
) PUNCT O
is AUX O
sufficient ADJ O
for ADP O
generating VERB O
rhythms NOUN O
in ADP O
vitro ADJ O
, PUNCT O
the DET O
cyanobacterial ADJ O
circadian ADJ O
system NOUN O
in ADP O
vivo ADJ O
also ADV O
includes VERB O
a DET O
transcriptional ADJ B-LF
/ SYM I-LF
translational ADJ I-LF
feedback NOUN I-LF
loop NOUN I-LF
( PUNCT O
TTFL PROPN B-AC
) PUNCT O
. PUNCT O
The DET O
precise ADJ O
roles NOUN O
of ADP O
the DET O
PTO PROPN B-AC
and CCONJ O
the DET O
TTFL PROPN B-AC
and CCONJ O
their PRON O
interdependence NOUN O
in ADP O
forming VERB O
the DET O
complete ADJ O
clock NOUN O
system NOUN O
in ADP O
vivo ADJ O
are AUX O
unclear ADJ O
. PUNCT O

We PRON O
analyzed VERB O
primary ADJ O
pure ADJ O
unilateral ADJ O
LCIS PROPN B-AC
( PUNCT O
International PROPN B-LF
Classification PROPN I-LF
of ADP I-LF
Diseases PROPN I-LF
for ADP I-LF
Oncology PROPN I-LF
, PUNCT I-LF
3rd ADJ I-LF
edition NOUN I-LF
[ X O
ICD PROPN B-AC
- PUNCT B-AC
O-3 NUM B-AC
] X O
histology NOUN O
codes NOUN O
8520)female NUM O
patients NOUN O
diagnosed VERB O
between ADP O
January PROPN O
1 NUM O
, PUNCT O
1998 NUM O
and CCONJ O
December PROPN O
31 NUM O
, PUNCT O
2007 NUM O
with ADP O
no DET O
cancer NOUN O
history NOUN O
that PRON O
were AUX O
reported VERB O
in ADP O
the DET O
SEER PROPN B-AC
18 NUM O
Registries PROPN O
. PUNCT O

The DET O
locus NOUN O
pairs NOUN O
selected VERB O
by ADP O
the DET O
two NUM O
methods NOUN O
for ADP O
each DET O
given VERB O
trait NOUN O
were AUX O
considered VERB O
to PART O
be AUX O
equivalent ADJ O
if SCONJ O
the DET O
same ADJ O
two NUM O
chromosomes NOUN O
were AUX O
identified VERB O
and CCONJ O
the DET O
respective ADJ O
chromosomal ADJ O
locations NOUN O
of ADP O
the DET O
loci NOUN O
were AUX O
within ADP O
50 NUM O
kilobases NOUN B-LF
( PUNCT O
kb NOUN B-AC
) PUNCT O
of ADP O
each DET O
other ADJ O
. PUNCT O

Such ADJ O
cortical ADJ B-LF
tracking NOUN I-LF
of ADP I-LF
speech NOUN I-LF
( PUNCT O
CTS NOUN B-AC
) PUNCT O
is AUX O
thought VERB O
to PART O
be AUX O
essential ADJ O
for ADP O
speech NOUN O
comprehension NOUN O
[ X O
33,35,37,39,41–43 NUM O
] PUNCT O
. PUNCT O

Immunoglobulin NOUN B-LF
( PUNCT O
Ig NOUN B-AC
) PUNCT O
genes NOUN O
are AUX O
further ADV O
diversified VERB O
after ADP O
V(D)J NOUN O
rearrangement NOUN O
by ADP O
gene NOUN O
conversion NOUN O
, PUNCT O
hypermutation NOUN O
, PUNCT O
or CCONJ O
a DET O
combination NOUN O
of ADP O
the DET O
two NUM O
. PUNCT O

In ADP O
keeping VERB O
with ADP O
our PRON O
in ADP O
vitro ADJ O
kinase NOUN O
assays NOUN O
, PUNCT O
we PRON O
found VERB O
that PRON O
PAK4S474E PROPN O
robustly ADV O
induced VERB O
β NOUN O
- PUNCT O
catenin NOUN O
phosphorylation NOUN O
at ADP O
Ser675 NOUN O
in ADP O
cells NOUN O
( PUNCT O
Fig PROPN O
6A NUM O
) PUNCT O
. PUNCT O
By ADP O
contrast NOUN O
, PUNCT O
we PRON O
observed VERB O
no DET O
increase NOUN O
in ADP O
phosphorylation NOUN O
upon SCONJ O
coexpression NOUN O
with ADP O
PAK4M4 PROPN O
/ SYM O
S474E PROPN O
or CCONJ O
with ADP O
kinase NOUN B-LF
- PUNCT I-LF
inactive ADJ I-LF
mutant ADJ I-LF
( PUNCT O
KD PROPN B-AC
) PUNCT O
PAK4 PROPN O
( PUNCT O
PAK4D440N PROPN O
/ SYM O
S474E PROPN O
) PUNCT O
. PUNCT O
To PART O
examine VERB O
substrate NOUN O
phosphorylation NOUN O
in ADP O
an DET O
endogenous ADJ O
setting NOUN O
, PUNCT O
we PRON O
performed VERB O
experiments NOUN O
in ADP O
Panc1 PROPN O
pancreatic ADJ O
cancer NOUN O
cells NOUN O
that PRON O
express VERB O
PAK4 PROPN O
to ADP O
high ADJ O
levels NOUN O
[ PUNCT O
52 NUM O
] PUNCT O
. PUNCT O

Recruitment NOUN O
of ADP O
participants NOUN O
into ADP O
randomised ADJ B-LF
controlled VERB I-LF
trials NOUN I-LF
( PUNCT O
RCTs NOUN B-AC
) PUNCT O
is AUX O
critical ADJ O
for ADP O
successful ADJ O
trial NOUN O
conduct NOUN O
. PUNCT O

They PRON O
showed VERB O
significantly ADV O
elevated VERB O
mean ADJ O
values NOUN O
of ADP O
triglycerides NOUN O
compared VERB O
with ADP O
subjects NOUN O
without ADP O
the DET O
metabolic ADJ O
syndrome NOUN O
, PUNCT O
but CCONJ O
decreased VERB O
values NOUN O
of ADP O
high ADJ B-LF
density NOUN I-LF
lipid NOUN I-LF
cholesterol NOUN I-LF
( PUNCT O
HDLC PROPN B-AC
) PUNCT O
. PUNCT O
Although SCONJ O
levels NOUN O
of ADP O
total ADJ O
cholesterol NOUN O
were AUX O
higher ADJ O
and CCONJ O
consumption NOUN O
of ADP O
total ADJ O
portions NOUN O
of ADP O
fruit NOUN O
and CCONJ O
vegetables NOUN O
were AUX O
lower ADJ O
in ADP O
subjects NOUN O
with ADP O
the DET O
metabolic ADJ O
syndrome NOUN O
than ADP O
those PRON O
without ADP O
, PUNCT O
the DET O
differences NOUN O
were AUX O
not PART O
statistically ADV O
significant ADJ O
. PUNCT O

Finally ADV O
, PUNCT O
50 NUM O
μg NOUN B-AC
/ SYM O
mL NOUN O
of ADP O
propidium NOUN B-LF
iodide NOUN I-LF
( PUNCT O
PI NOUN B-AC
) PUNCT O
was AUX O
added VERB O
for ADP O
20 NUM O
minutes NOUN O
on ADP O
ice NOUN O
. PUNCT O

Forced VERB B-LF
expiratory ADJ I-LF
volume NOUN I-LF
in ADP I-LF
1 NUM I-LF
sec NOUN I-LF
( PUNCT O
FEV1 NOUN B-AC
) PUNCT O
( PUNCT O
% PUNCT O
predicted VERB O
) PUNCT O
and CCONJ O
FEV1 NOUN B-AC
/ SYM O
forced VERB B-LF
vital ADJ I-LF
capacity NOUN I-LF
( PUNCT O
FVC PROPN B-AC
) PUNCT O
ratio NOUN O
were AUX O
significantly ADV O
lower ADJ O
in ADP O
subjects NOUN O
with ADP O
severe ADJ O
compared VERB O
to ADP O
mild ADJ O
/ SYM O
moderate ADJ O
asthma NOUN O
. PUNCT O

Heart NOUN B-LF
failure NOUN I-LF
with ADP I-LF
reduced ADJ I-LF
ejection NOUN I-LF
fraction NOUN I-LF
( PUNCT O
HFrEF PROPN B-AC
; PUNCT O
left ADJ O
ventricular ADJ O
ejection NOUN O
fraction NOUN O
< ADP O
45 NUM O
% PUNCT O
) PUNCT O
is AUX O
a DET O
potential ADJ O
end NOUN O
- NOUN O
stage NOUN O
of ADP O
various ADJ O
cardiac ADJ O
diseases NOUN O
and CCONJ O
represents VERB O
an DET O
enormous ADJ O
public ADJ O
health NOUN O
and CCONJ O
socioeconomic ADJ O
burden NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

To PART O
examine VERB O
the DET O
resolution NOUN O
at ADP O
which PRON O
illness NOUN O
might AUX O
be AUX O
confidently ADV O
identified VERB O
, PUNCT O
we PRON O
developed VERB O
a DET O
computational ADJ O
approach NOUN O
called VERB O
“ PUNCT O
Change PROPN B-LF
- PUNCT I-LF
of ADP I-LF
- PUNCT I-LF
Heart NOUN I-LF
” PUNCT O
or CCONJ O
COH PROPN B-AC
to PART O
identify VERB O
periods NOUN O
with ADP O
abnormal ADJ O
HR NOUN B-AC
patterns NOUN O
. PUNCT O

BMI PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
TNFi PROPN B-AC
, PUNCT O
tumour NOUN O
necrosis NOUN O
factor NOUN O
inhibitor NOUN O
. PUNCT O

DIMM PROPN B-AC
, PUNCT O
dual ADJ B-LF
input NOUN I-LF
Mother PROPN I-LF
Machine PROPN I-LF
. PUNCT O

1 X O
. PUNCT O
The DET O
topic NOUN O
of ADP O
the DET O
manuscript NOUN O
is AUX O
“ PUNCT O
Prostate PROPN B-LF
- PUNCT I-LF
Specific PROPN I-LF
Antigen PROPN I-LF
Dynamics PROPN O
After ADP O
Carbon PROPN B-LF
Ion NOUN I-LF
Radiotherapy PROPN I-LF
for ADP O
Prostate PROPN O
Cancer PROPN O
. PUNCT O
” PUNCT O
If SCONJ O
the DET O
authors NOUN O
were AUX O
not PART O
able ADJ O
to ADP O
confirm VERB O
whether SCONJ O
the DET O
PSA NOUN B-AC
dynamics NOUN O
was AUX O
due ADJ O
to ADP O
the DET O
effect NOUN O
of ADP O
CIRT PROPN B-AC
, PUNCT O
ADT PROPN B-AC
or CCONJ O
both PRON O
, PUNCT O
the DET O
issue NOUN O
of ADP O
this DET O
investigation NOUN O
should AUX O
be AUX O
“ PUNCT O
Prostate PROPN B-LF
- PUNCT I-LF
Specific PROPN I-LF
Antigen PROPN I-LF
Dynamics PROPN O
After ADP O
Neoadjuvant PROPN O
ADT PROPN B-AC
and CCONJ O
CIRT PROPN B-AC
for ADP O
Prostate PROPN O
Cancer PROPN O
. PUNCT O
” PUNCT O
Precisely ADV O
, PUNCT O
the DET O
study NOUN O
demonstrated VERB O
the DET O
prostate NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
antigen NOUN I-LF
dynamics NOUN O
after ADP O
neoadjuvant ADJ O
androgen NOUN B-LF
- PUNCT I-LF
deprivation NOUN I-LF
therapy NOUN I-LF
combined VERB O
with ADP O
carbon NOUN B-LF
ion NOUN I-LF
radiotherapy NOUN I-LF
for ADP O
intermediate ADJ O
risk NOUN O
prostate NOUN O
cancer NOUN O
patients NOUN O
. PUNCT O

Patients NOUN O
with ADP O
a DET O
clinical ADJ O
suspect NOUN O
of ADP O
ACD PROPN B-AC
or CCONJ O
SNAS PROPN B-AC
that PRON O
met VERB O
inclusion NOUN O
and CCONJ O
exclusion NOUN O
criteria NOUN O
were AUX O
patch NOUN O
tested VERB O
with ADP O
the DET O
Società PROPN B-LF
Italiana PROPN I-LF
Dermatologia PROPN I-LF
Allergologica PROPN I-LF
Professionale PROPN I-LF
ed PROPN I-LF
Ambientale PROPN I-LF
( PUNCT O
SIDAPA PROPN B-AC
) PUNCT O
baseline NOUN O
series NOUN O
( PUNCT O
Lofarma PROPN O
S.p PROPN O
. PUNCT O
A. PROPN O
, PUNCT O
Milano PROPN O
, PUNCT O
Italy PROPN O
) PUNCT O
, PUNCT O
that PRON O
assess VERB O
Ni PROPN B-AC
sensitivity NOUN O
with ADP O
a DET O
5 NUM O
% NOUN O
Nickel PROPN B-LF
Sulfate PROPN O
solution NOUN O
. PUNCT O

NK PROPN B-AC
, PUNCT O
natural ADJ B-LF
killer NOUN I-LF
; PUNCT O
7KC PROPN B-AC
, PUNCT O
7 NUM B-LF
- PUNCT I-LF
ketocholesterol NOUN I-LF
. PUNCT O

ROI NOUN B-AC
, PUNCT O
return NOUN B-LF
on ADP I-LF
investment NOUN I-LF
. PUNCT O

Abbreviations NOUN O
: PUNCT O
ACTOMgSO4 PROPN B-AC
, PUNCT O
Australasian PROPN B-LF
Collaborative PROPN I-LF
Trial PROPN I-LF
of ADP I-LF
Magnesium PROPN I-LF
Sulphate PROPN I-LF
; PUNCT O
BEAM PROPN B-AC
, PUNCT O
Beneficial PROPN B-LF
Effects PROPN I-LF
of ADP I-LF
Antenatal PROPN I-LF
Magnesium PROPN I-LF
Sulfate PROPN I-LF
; PUNCT O
MAGNET PROPN B-AC
, PUNCT O
Magnesium PROPN B-LF
and CCONJ I-LF
Neurologic PROPN I-LF
Endpoints PROPN I-LF
Trial PROPN I-LF
; PUNCT O
MAGPIE PROPN B-AC
, PUNCT O
MAGnesium PROPN B-LF
sulphate NOUN I-LF
for ADP I-LF
Prevention PROPN I-LF
of ADP I-LF
Eclampsia PROPN I-LF
; PUNCT O
PREMAG PROPN B-AC
, PUNCT O
PREterm PROPN O
brain NOUN O
protection NOUN O
by ADP O
MAGnesium PROPN O
. PUNCT O

To PART O
test VERB O
this DET O
possibility NOUN O
, PUNCT O
we PRON O
grew VERB O
eDR5::LUC NOUN B-AC
plants NOUN O
on ADP O
media NOUN O
containing VERB O
N-1 NOUN B-LF
- PUNCT I-LF
naphthylphthalamic ADJ I-LF
acid NOUN I-LF
( PUNCT O
NPA PROPN B-AC
) PUNCT O
, PUNCT O
an DET O
inhibitor NOUN O
of ADP O
the DET O
auxin NOUN O
transport NOUN O
machinery NOUN O
. PUNCT O

Underlying VERB O
numerical ADJ O
values NOUN O
can AUX O
be AUX O
found VERB O
in ADP O
S16 PROPN O
Data PROPN O
. PUNCT O
nEZ PROPN B-AC
, PUNCT O
nonepileptogenic ADJ B-LF
zone NOUN I-LF
; PUNCT O
RZ PROPN B-AC
, PUNCT O
resected VERB B-LF
zone NOUN I-LF
; PUNCT O
SOZ PROPN B-AC
, PUNCT O
seizure NOUN B-LF
- PUNCT I-LF
onset NOUN I-LF
zone NOUN I-LF
. PUNCT O

We PRON O
showed VERB O
that SCONJ O
PDGF PROPN B-AC
signaling NOUN O
primarily ADV O
activates VERB O
the DET O
Phosphoinositide NOUN B-LF
3 NUM I-LF
- PUNCT I-LF
kinase PROPN I-LF
( PUNCT O
PI3K)–Protein PROPN B-LF
kinase PROPN I-LF
B PROPN I-LF
( PUNCT O
AKT PROPN B-AC
) PUNCT O
pathway NOUN O
in ADP O
lens NOUN O
development NOUN O
and CCONJ O
the DET O
direct ADJ O
binding NOUN O
of ADP O
PI3 PROPN B-AC
K PROPN B-AC
to ADP O
PDGFRα PROPN B-AC
is AUX O
required VERB O
for ADP O
preventing VERB O
the DET O
depletion NOUN O
of ADP O
lens NOUN O
epithelial ADJ O
cells NOUN O
. PUNCT O

We PRON O
quantified VERB O
radial ADJ O
sorting VERB O
defects NOUN O
in ADP O
sciatic ADJ O
nerves NOUN O
at ADP O
postnatal ADJ B-LF
day NOUN I-LF
16 NUM I-LF
( PUNCT O
P16 PROPN B-AC
) PUNCT O
because SCONJ O
Lama2−/− NOUN O
mice NOUN O
in ADP O
the DET O
C57 PROPN O
/ SYM O
BL6 PROPN O
background NOUN O
die VERB O
around ADP O
P21 PROPN O
. PUNCT O

ACEI PROPN B-AC
, PUNCT O
angiotensin NOUN B-LF
- PUNCT I-LF
converting VERB I-LF
enzyme NOUN I-LF
inhibitor NOUN I-LF
; PUNCT O
ARB PROPN B-AC
, PUNCT O
angiotensin NOUN B-LF
II NUM I-LF
receptor NOUN I-LF
blocker NOUN I-LF
. PUNCT O

Total ADJ B-LF
knee NOUN I-LF
arthroplasty NOUN I-LF
( PUNCT O
TKA NOUN B-AC
) PUNCT O
is AUX O
often ADV O
performed VERB O
in ADP O
the DET O
late ADJ O
stage NOUN O
of ADP O
knee NOUN O
arthritis NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

SD NOUN O
: PUNCT O
Standard ADJ O
deviation NOUN O
, PUNCT O
LVIDd NOUN O
: PUNCT O
Left ADJ O
ventricular ADJ O
internal ADJ O
diameter NOUN O
in ADP O
diastole NOUN O
, PUNCT O
LVPWd NOUN O
: PUNCT O
Posterior ADJ O
wall NOUN O
thickness NOUN O
in ADP O
diastole NOUN O
, PUNCT O
IVSd NOUN O
: PUNCT O
Septum NOUN O
wall NOUN O
thickness NOUN O
in ADP O
diastole NOUN O
, PUNCT O
LVMI NOUN B-AC
: PUNCT O
Left ADJ B-LF
ventricular ADJ I-LF
mass NOUN I-LF
index NOUN I-LF
, PUNCT O
LAVI PROPN B-AC
: PUNCT O
Left ADJ B-LF
atrium NOUN I-LF
volume NOUN I-LF
index NOUN I-LF
. PUNCT O

In ADP O
the DET O
tested VERB O
samples NOUN O
of ADP O
6,017 NUM O
PMC PROPN B-AC
articles NOUN O
, PUNCT O
the DET O
accuracy NOUN O
, PUNCT O
positive ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
( PUNCT O
PPV NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
negative ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
( PUNCT O
NPV NOUN B-AC
) PUNCT O
of ADP O
all DET O
5 NUM O
algorithms NOUN O
was AUX O
≥88 NUM O
% NOUN O
( PUNCT O
Fig PROPN O
2 NUM O
) PUNCT O
. PUNCT O

We PRON O
then ADV O
integrated VERB O
these DET O
AD PROPN B-AC
- PUNCT O
associated VERB O
SNPs NOUN B-AC
into ADP O
a DET O
Cox PROPN O
proportional ADJ O
hazard NOUN O
model NOUN O
using VERB O
genotype NOUN O
data NOUN O
from ADP O
a DET O
subset NOUN O
of ADP O
6,409 NUM O
AD PROPN B-AC
patients NOUN O
and CCONJ O
9,386 NUM O
older ADJ O
controls NOUN O
from ADP O
Phase PROPN O
1 NUM O
of ADP O
the DET O
Alzheimer PROPN B-LF
’s PART I-LF
Disease PROPN I-LF
Genetics PROPN I-LF
Consortium PROPN I-LF
( PUNCT O
ADGC PROPN B-AC
) PUNCT O
, PUNCT O
providing VERB O
a DET O
polygenic ADJ B-LF
hazard NOUN I-LF
score NOUN I-LF
( PUNCT O
PHS PROPN B-AC
) PUNCT O
for ADP O
each DET O
participant NOUN O
. PUNCT O

While SCONJ O
some DET O
Hh PROPN B-AC
co VERB O
- PUNCT O
fractionates NOUN O
with ADP O
residual ADJ O
Lpp PROPN B-AC
, PUNCT O
most ADJ O
is AUX O
present ADJ O
in ADP O
dense ADJ O
fractions NOUN O
that PRON O
do AUX O
not PART O
contain VERB O
apoLII NOUN B-AC
, PUNCT O
a DET O
scaffolding NOUN O
protein NOUN O
of ADP O
Lpp PROPN B-AC
( PUNCT O
Figure PROPN O
2C NUM O
) PUNCT O
. PUNCT O
Reduced VERB O
sterol NOUN O
levels NOUN O
can AUX O
not PART O
account VERB O
for ADP O
the DET O
appearance NOUN O
of ADP O
high ADJ O
- PUNCT O
density NOUN O
Hh PROPN B-AC
, PUNCT O
because SCONJ O
dietary ADJ O
sterol NOUN O
depletion NOUN O
does AUX O
not PART O
produce VERB O
this DET O
phenotype NOUN O
( PUNCT O
Figure PROPN O
S3E NUM O
, PUNCT O
F NUM O
) PUNCT O
. PUNCT O
In ADP O
addition NOUN O
to ADP O
Lpp PROPN B-AC
, PUNCT O
Drosophila PROPN O
hemolymph NOUN O
contains VERB O
two NUM O
minor ADJ O
lipoproteins NOUN O
of ADP O
higher ADJ O
density NOUN O
, PUNCT O
Lipid PROPN B-LF
Transfer PROPN I-LF
Particle PROPN I-LF
( PUNCT O
LTP PROPN B-AC
) PUNCT O
and CCONJ O
Crossveinless PROPN B-LF
- PUNCT I-LF
d PROPN I-LF
( PUNCT O
Cv PROPN B-AC
- PUNCT B-AC
d PROPN B-AC
) PUNCT O
[ PUNCT O
26 NUM O
] PUNCT O
. PUNCT O

The DET O
serum NOUN O
iohexol NOUN O
concentration NOUN O
was AUX O
measured VERB O
by ADP O
High PROPN B-LF
Performance PROPN I-LF
Liquid PROPN I-LF
Chromatography PROPN I-LF
( PUNCT O
HPLC PROPN B-AC
) PUNCT O
. PUNCT O
External ADJ O
quality NOUN O
control NOUN O
was AUX O
provided VERB O
by ADP O
Equalis PROPN O
( PUNCT O
Uppsala PROPN O
, PUNCT O
Sweden PROPN O
) PUNCT O
every DET O
3 NUM O
months NOUN O
. PUNCT O

Note VERB O
: PUNCT O
Multistate ADJ O
models NOUN O
of ADP O
104,719 NUM O
patients NOUN O
on ADP O
first ADJ O
- PUNCT O
line NOUN O
ART PROPN B-AC
. PUNCT O
ART PROPN B-AC
, PUNCT O
antiretroviral ADJ B-LF
treatment NOUN I-LF
; PUNCT O
ITT PROPN O
, PUNCT O
intention NOUN O
- PUNCT O
to PART O
- PUNCT O
treat VERB O
; PUNCT O
LTFU PROPN B-AC
, PUNCT O
loss NOUN B-LF
to PART I-LF
follow VERB I-LF
- PUNCT I-LF
up ADP I-LF
; PUNCT O
OT PROPN O
, PUNCT O
on ADP O
- PUNCT O
treatment NOUN O
; PUNCT O
VL PROPN B-AC
, PUNCT O
viral ADJ O
load NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
NA PROPN O
, PUNCT O
not PART O
applicable ADJ O
; PUNCT O
SEHER PROPN B-AC
, PUNCT O
Strengthening VERB B-LF
Evidence NOUN I-LF
base NOUN I-LF
on ADP I-LF
scHool NOUN I-LF
- PUNCT I-LF
based VERB I-LF
intErventions NOUN I-LF
for ADP I-LF
pRomoting VERB I-LF
adolescent ADJ I-LF
health NOUN I-LF
; PUNCT O
SM PROPN B-AC
, PUNCT O
SEHER PROPN B-LF
Mitra PROPN I-LF
; PUNCT O
TSM PROPN B-AC
, PUNCT O
Teacher NOUN B-LF
as ADP I-LF
SEHER PROPN I-LF
Mitra PROPN I-LF

LTFU PROPN B-AC
, PUNCT O
loss NOUN B-LF
to ADP I-LF
follow NOUN I-LF
- PUNCT I-LF
up ADP I-LF
; PUNCT O
TS PROPN B-AC
, PUNCT O
treatment NOUN B-LF
success NOUN I-LF
. PUNCT O

CPXV203 PROPN O
/ SYM O
Kb NOUN O
mutations NOUN O
that PRON O
significantly ADV O
increased VERB O
surface NOUN O
Kb NOUN O
expression NOUN O
also ADV O
exhibited VERB O
a DET O
decrease NOUN O
in ADP O
total ADJ O
Kb NOUN O
( PUNCT O
lysate NOUN O
) PUNCT O
, PUNCT O
indicative ADJ O
of ADP O
the DET O
release NOUN O
of ADP O
MHCI PROPN B-AC
retention NOUN O
[ X O
28 NUM O
] PUNCT O
. PUNCT O
( PUNCT O
E NOUN O
) PUNCT O
Kinetic ADJ O
analysis NOUN O
( PUNCT O
SPR PROPN B-AC
) PUNCT O
of ADP O
alanine ADJ O
mutation NOUN O
of ADP O
α3 NOUN O
interface NOUN O
histidines NOUN O
( PUNCT O
CPXV203 PROPN O
H75 PROPN O
and CCONJ O
H80 PROPN O
) PUNCT O
summarized VERB O
by ADP O
on NOUN B-LF
- PUNCT I-LF
rate NOUN I-LF
( PUNCT O
ka NOUN B-AC
, PUNCT O
( PUNCT O
+ PUNCT O
) PUNCT O
-axis NOUN O
) PUNCT O
and CCONJ O
half ADJ O
- PUNCT O
life NOUN O
( PUNCT O
half ADJ O
- PUNCT O
life NOUN O
, PUNCT O
( PUNCT O
−)-axis NOUN O
) PUNCT O
. PUNCT O
( PUNCT O
F NOUN O
) PUNCT O
Summary NOUN O
of ADP O
mutagenic ADJ O
analysis NOUN O
( PUNCT O
functional ADJ O
and CCONJ O
biosensor ADJ O
) PUNCT O
mapped VERB O
to ADP O
CPXV203 PROPN O
/ SYM O
MHCI PROPN B-AC
structure NOUN O
( PUNCT O
same ADJ O
colors NOUN O
as ADP O
Figure NOUN O
3A NUM O
) PUNCT O
shown VERB O
as ADP O
cartoon NOUN O
loops NOUN O
except SCONJ O
for ADP O
the DET O
peptide NOUN O
( PUNCT O
spheres NOUN O
) PUNCT O
. PUNCT O

In ADP O
a DET O
subset NOUN O
of ADP O
ROS PROPN B-AC
, PUNCT O
MAP PROPN B-AC
, PUNCT O
and CCONJ O
MARS PROPN B-AC
participants NOUN O
, PUNCT O
serum ADJ O
thyroid NOUN B-LF
stimulating VERB I-LF
hormone NOUN I-LF
( PUNCT O
TSH PROPN B-AC
) PUNCT O
levels NOUN O
were AUX O
assessed VERB O
by ADP O
immunoassay NOUN O
by ADP O
Quest PROPN O
Diagnostics PROPN O
( PUNCT O
Madison PROPN O
, PUNCT O
NJ PROPN O
, PUNCT O
US PROPN O
) PUNCT O
. PUNCT O

ADQoL PROPN B-AC
, PUNCT O
Atopic PROPN B-LF
Dermatitis PROPN I-LF
Quality PROPN I-LF
of ADP I-LF
Life PROPN I-LF
; PUNCT O
CHU-9D PROPN O
, PUNCT O
Child PROPN O
Health PROPN O
Utility PROPN O
9 NUM O
Dimensions NOUN O
; PUNCT O
DFI PROPN B-AC
, PUNCT O
Dermatitis PROPN B-LF
Family PROPN I-LF
Impact PROPN I-LF
; PUNCT O
N NOUN O
/ SYM O
A NOUN O
, PUNCT O
not PART O
applicable ADJ O
; PUNCT O
SD NOUN B-AC
, PUNCT O
standard ADJ B-LF
deviation NOUN I-LF
. PUNCT O

Based VERB O
on ADP O
the DET O
immunoprecipitation NOUN O
sequencing NOUN O
data NOUN O
( PUNCT O
S14A PROPN O
Fig PROPN O
, PUNCT O
S5 PROPN O
Table PROPN O
) PUNCT O
, PUNCT O
together ADV O
with ADP O
target NOUN O
prediction NOUN O
( PUNCT O
S14B PROPN O
Fig PROPN O
) PUNCT O
, PUNCT O
luciferase NOUN O
reporter NOUN O
assay NOUN O
( PUNCT O
S14C PROPN O
Fig PROPN O
) PUNCT O
, PUNCT O
and CCONJ O
QRT NOUN B-AC
- PUNCT B-AC
PCR NOUN B-AC
analysis NOUN O
( PUNCT O
S14D PROPN O
Fig PROPN O
) PUNCT O
, PUNCT O
we PRON O
found VERB O
that SCONJ O
inhibin NOUN B-LF
subunit NOUN I-LF
beta NOUN I-LF
A NOUN I-LF
( PUNCT O
Inhba PROPN B-AC
) PUNCT O
and CCONJ O
DNA NOUN B-LF
methyltransferase NOUN I-LF
3 NUM I-LF
alpha NOUN I-LF
( PUNCT O
Dnmt3a PROPN B-AC
) PUNCT O
act VERB O
as ADP O
direct ADJ O
targets NOUN O
of ADP O
miR-26a NOUN O
. PUNCT O

Mean ADJ O
LVMI PROPN B-AC
was AUX O
82.7 NUM O
± SYM O
30.6 NUM O
and CCONJ O
145 NUM O
patients NOUN O
had VERB O
late ADJ B-LF
gadolinium NOUN I-LF
enhancement NOUN I-LF
( PUNCT O
LGE PROPN B-AC
) PUNCT O
. PUNCT O
Patients NOUN O
with ADP O
beta NOUN B-LF
- PUNCT I-LF
myosin NOUN I-LF
heavy ADJ I-LF
chain NOUN I-LF
( PUNCT O
MYH7 PROPN B-AC
) PUNCT O
mutations NOUN O
had VERB O
higher ADJ O
LV PROPN B-AC
ejection NOUN O
fraction NOUN O
( PUNCT O
68.8 NUM O
vs ADP O
59.1 NUM O
, PUNCT O
p<0.001 NUM O
) PUNCT O
than ADP O
those PRON O
with ADP O
cardiac ADJ B-LF
myosin NOUN I-LF
binding VERB I-LF
protein NOUN I-LF
C PROPN I-LF
( PUNCT O
MYBPC3 PROPN B-AC
) PUNCT O
mutations NOUN O
. PUNCT O

Malnutrition NOUN O
was AUX O
defined VERB O
for ADP O
patients NOUN O
< ADP O
5 NUM O
years NOUN O
old ADJ O
as ADP O
a DET O
mid ADJ O
- NOUN O
upper ADJ O
arm NOUN O
circumference NOUN O
< ADP O
115 NUM O
mm NOUN O
, PUNCT O
in ADP O
patients NOUN O
aged VERB O
≥5 NUM O
years NOUN O
to ADP O
≤19 NUM O
years NOUN O
using VERB O
the DET O
World PROPN O
Health PROPN O
Organization PROPN O
age- NOUN O
and CCONJ O
sex NOUN O
- NOUN O
specific ADJ O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT O
BMI)-for NOUN B-AC
- NOUN O
age NOUN O
z NOUN O
- NOUN O
scores NOUN O
[ PUNCT O
24 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
for ADP O
adults NOUN O
> NUM O
19 NUM O
years NOUN O
old ADJ O
as ADP O
a DET O
BMI NOUN B-AC
< ADP O
18.5 NUM O
kg NOUN O
/ SYM O
m2 NOUN O
. PUNCT O

d X O
SCNT PROPN B-AC
: PUNCT O
somatic ADJ B-LF
cell NOUN I-LF
nuclear ADJ I-LF
transfer NOUN I-LF
. PUNCT O

This DET O
dysbiosis NOUN O
translated VERB O
into ADP O
420 NUM O
different ADJ O
operational ADJ B-LF
taxonomic ADJ I-LF
units NOUN I-LF
( PUNCT O
OTUs NOUN B-AC
) PUNCT O
. PUNCT O

IVH PROPN B-AC
, PUNCT O
intraventricular ADJ B-LF
haemorrhage NOUN I-LF
; PUNCT O
ICH PROPN O
, PUNCT O
intracerebral ADJ O
haemorrhage NOUN O
; PUNCT O
PVH NOUN O
, PUNCT O
periventricular ADJ O
haemorrhage NOUN O
; PUNCT O
PVL PROPN B-AC
, PUNCT O
periventricular ADJ B-LF
leukomalacia NOUN I-LF
. PUNCT O

The DET O
goal NOUN O
of ADP O
this DET O
study NOUN O
is AUX O
to ADP O
address VERB O
these DET O
2 NUM O
challenges NOUN O
related VERB O
to ADP O
neural ADJ O
encoding NOUN O
in ADP O
the DET O
cortex NOUN O
by ADP O
focusing VERB O
on ADP O
a DET O
subject NOUN O
that PRON O
has AUX O
already ADV O
been AUX O
well ADV O
- PUNCT O
studied VERB O
: PUNCT O
the DET O
encoding NOUN O
of ADP O
rodent ADJ O
socialization NOUN O
by ADP O
neurons NOUN O
in ADP O
the DET O
medial ADJ B-LF
prefrontal ADJ I-LF
cortex NOUN I-LF
( PUNCT O
mPFC PROPN B-AC
) PUNCT O
[ X O
17–20 NUM O
] PUNCT O
. PUNCT O

DWV PROPN B-AC
, PUNCT O
deformed VERB B-LF
wing NOUN I-LF
virus NOUN I-LF
; PUNCT O
IRES PROPN B-AC
, PUNCT O
internal ADJ B-LF
ribosome NOUN I-LF
entry NOUN I-LF
site NOUN I-LF
; PUNCT O
LP PROPN B-AC
, PUNCT O
leader NOUN B-LF
protein NOUN I-LF
; PUNCT O
NGS PROPN B-AC
, PUNCT O
next ADJ B-LF
- PUNCT I-LF
generation NOUN I-LF
sequencing NOUN I-LF
; PUNCT O
Prot PROPN O
, PUNCT O
viral ADJ O
protease NOUN O
; PUNCT O
RdRpol PROPN B-AC
, PUNCT O
RNA NOUN B-LF
- PUNCT I-LF
dependent ADJ I-LF
RNA NOUN I-LF
polymerase NOUN I-LF
; PUNCT O
RNAi PROPN B-AC
, PUNCT O
RNA NOUN B-LF
interference NOUN I-LF
; PUNCT O
small ADJ O
interfering VERB O
RNA NOUN O
; PUNCT O
VP PROPN B-AC
, PUNCT O
structural ADJ B-LF
viral ADJ I-LF
protein NOUN I-LF
. PUNCT O

Here ADV O
, PUNCT O
we PRON O
report VERB O
that SCONJ O
αSacetyl NOUN B-AC
is AUX O
more ADV O
effective ADJ O
at ADP O
inducing VERB O
intracellular ADJ O
aggregation NOUN O
in ADP O
primary ADJ O
neurons NOUN O
than ADP O
unmodified ADJ B-LF
αS NOUN I-LF
( PUNCT O
αSun PROPN B-AC
) PUNCT O
. PUNCT O

LN NOUN B-AC
, PUNCT O
Lymph NOUN B-LF
node NOUN I-LF
; PUNCT O
PT NOUN B-AC
, PUNCT O
Primary ADJ B-LF
tumor NOUN I-LF
; PUNCT O
ER NOUN B-AC
, PUNCT O
estrogen NOUN B-LF
receptor NOUN I-LF
; PUNCT O
PR NOUN B-AC
, PUNCT O
progesterone NOUN B-LF
receptor NOUN I-LF
; PUNCT O

We PRON O
fitted VERB O
weighted VERB O
Cox PROPN O
proportional ADJ O
hazards NOUN O
models NOUN O
using VERB O
the DET O
inverse ADJ B-LF
probability NOUN I-LF
of ADP I-LF
treatment NOUN I-LF
weighting NOUN I-LF
( PUNCT O
IPTW PROPN B-AC
) PUNCT O
[ PUNCT O
10 NUM O
] PUNCT O
. PUNCT O

COPD PROPN B-AC
, PUNCT O
chronic ADJ B-LF
obstructive ADJ I-LF
pulmonary ADJ I-LF
disease NOUN I-LF
; PUNCT O
PPV23 PROPN B-AC
, PUNCT O
23 NUM B-LF
- PUNCT I-LF
valent NOUN I-LF
pneumococcal NOUN I-LF
polysaccharide NOUN I-LF
vaccine NOUN I-LF
. PUNCT O

PACE PROPN B-AC
- PUNCT B-AC
Lift NOUN B-AC
, PUNCT O
Pedometer NOUN B-LF
Accelerometer NOUN I-LF
Consultation PROPN I-LF
Evaluation PROPN I-LF
- PUNCT I-LF
Lift NOUN I-LF
; PUNCT O
PACE PROPN B-AC
- PUNCT B-AC
UP PROPN B-AC
, PUNCT O
Pedometer NOUN B-LF
And CCONJ I-LF
Consultation PROPN I-LF
Evaluation PROPN I-LF
- PUNCT I-LF
UP PROPN I-LF
. PUNCT O

The DET O
method NOUN O
of ADP O
determination NOUN O
of ADP O
8 NUM B-LF
- PUNCT I-LF
isoprostanes NOUN I-LF
( PUNCT O
8 NUM B-AC
- PUNCT B-AC
EPI NOUN B-AC
) PUNCT O
in ADP O
biological ADJ O
samples NOUN O
has AUX O
been AUX O
described VERB O
and CCONJ O
accepted VERB O
( PUNCT O
BIOXYTECH PROPN O
8 NUM O
- PUNCT O
Isoprostane NOUN O
Assay PROPN O
, PUNCT O
Cat PROPN O
. PUNCT O

If SCONJ O
a DET O
fraction NOUN O
of ADP O
ISWI PROPN O
is AUX O
PARylated VERB B-AC
in ADP O
vivo ADJ O
, PUNCT O
we PRON O
might AUX O
expect VERB O
this DET O
level NOUN O
to PART O
increase VERB O
when SCONJ O
the DET O
activity NOUN O
of ADP O
PARP PROPN B-AC
is AUX O
not PART O
counterbalanced VERB O
by ADP O
the DET O
action NOUN O
of ADP O
PARG PROPN B-AC
, PUNCT O
the DET O
poly ADJ B-LF
- PUNCT I-LF
ADP NOUN I-LF
- PUNCT I-LF
ribose NOUN I-LF
glycohydrolase NOUN I-LF
that PRON O
reverses VERB O
the DET O
enzymatic ADJ O
activity NOUN O
of ADP O
PARP PROPN B-AC
[ PUNCT O
17,18 NUM O
] PUNCT O
. PUNCT O

Indeed ADV O
, PUNCT O
many ADJ O
people NOUN O
living VERB O
in ADP O
the DET O
US PROPN O
and CCONJ O
Europe PROPN O
( PUNCT O
in ADP O
particular ADJ O
, PUNCT O
elderly ADJ O
people NOUN O
, PUNCT O
breastfed VERB O
infants NOUN O
, PUNCT O
people NOUN O
with ADP O
dark ADJ O
skin NOUN O
, PUNCT O
and CCONJ O
obese ADJ O
individuals NOUN O
) PUNCT O
have VERB O
serum NOUN O
( PUNCT O
circulating VERB O
) PUNCT O
25 NUM B-LF
- PUNCT I-LF
hydroxy NOUN I-LF
- PUNCT I-LF
vitamin NOUN I-LF
D NOUN I-LF
( PUNCT O
25OHD NOUN B-AC
) PUNCT O
levels NOUN O
below ADP O
50 NUM O
nmol NOUN O
/ SYM O
l NOUN O
, PUNCT O
the DET O
threshold NOUN O
for ADP O
vitamin NOUN O
D NOUN O
deficiency NOUN O
. PUNCT O

An DET O
anti ADJ O
- PUNCT O
PKG PROPN B-AC
- PUNCT B-AC
I NOUN B-AC
antibody NOUN O
[ X O
18 NUM O
] PUNCT O
yielded VERB O
specific ADJ O
staining NOUN O
in ADP O
wild ADJ O
- PUNCT O
type NOUN O
dorsal ADJ B-LF
root NOUN I-LF
ganglia NOUN I-LF
( PUNCT O
DRG PROPN B-AC
) PUNCT O
, PUNCT O
but CCONJ O
not PART O
in ADP O
those PRON O
from ADP O
global ADJ O
PKG PROPN B-AC
- PUNCT B-AC
I−/− SYM O
mice NOUN O
[ X O
19 NUM O
] PUNCT O
, PUNCT O
thereby ADV O
revealing VERB O
Cre NOUN O
/ SYM O
loxP NOUN O
- PUNCT O
mediated VERB O
deletion NOUN O
of ADP O
PKG PROPN B-AC
- PUNCT B-AC
I NOUN B-AC
in ADP O
DRG PROPN B-AC
of ADP O
SNS PROPN O
- PUNCT O
PKG PROPN B-AC
- PUNCT B-AC
I−/− SYM O
mice NOUN O
( PUNCT O
Figure NOUN O
1A NUM O
) PUNCT O
. PUNCT O
Quantitative ADJ O
size NOUN O
- PUNCT O
frequency NOUN O
analysis NOUN O
revealed VERB O
that SCONJ O
a DET O
majority NOUN O
of ADP O
DRG PROPN B-AC
neurons NOUN O
expressing VERB O
PKG PROPN B-AC
- PUNCT B-AC
I NOUN B-AC
in ADP O
wild ADJ O
- PUNCT O
type NOUN O
mice NOUN O
are AUX O
small ADJ O
- PUNCT O
diameter NOUN O
neurons NOUN O
, PUNCT O
which PRON O
show VERB O
a DET O
near ADV O
complete ADJ O
loss NOUN O
of ADP O
PKG PROPN B-AC
- PUNCT B-AC
I NOUN B-AC
expression NOUN O
in ADP O
SNS PROPN O
- PUNCT O
PKG PROPN B-AC
- PUNCT B-AC
I−/− SYM O
mice NOUN O
( PUNCT O
Figure NOUN O
1B NUM O
; PUNCT O
p<0.001 NUM O
) PUNCT O
. PUNCT O

The DET O
first ADJ O
- PUNCT O
stage NOUN O
sampling NOUN O
frame NOUN O
consists VERB O
of ADP O
a DET O
list NOUN O
of ADP O
primary ADJ B-LF
sampling NOUN I-LF
units NOUN I-LF
( PUNCT O
PSUs PROPN B-AC
) PUNCT O
or CCONJ O
enumeration NOUN O
areas NOUN O
( PUNCT O
EAs NOUN B-AC
) PUNCT O
that PRON O
covered VERB O
the DET O
entire ADJ O
country NOUN O
and CCONJ O
usually ADV O
were AUX O
obtained VERB O
from ADP O
the DET O
latest ADJ O
national ADJ O
census NOUN O
— PUNCT O
when SCONJ O
available ADJ O
. PUNCT O

Furthermore ADV O
, PUNCT O
galectin NOUN B-LF
( PUNCT O
Gal)-9 NUM B-AC
was AUX O
found VERB O
elevated ADJ O
in ADP O
AH PROPN B-AC
[ X O
17 NUM O
] PUNCT O
. PUNCT O

Moreover ADV O
, PUNCT O
the DET O
minor ADJ B-LF
allele NOUN I-LF
frequency NOUN I-LF
( PUNCT O
MAF NOUN B-AC
) PUNCT O
of ADP O
the DET O
SNPs NOUN B-AC
detected VERB O
by ADP O
NGS PROPN O
was AUX O
extracted VERB O
from ADP O
Single PROPN B-LF
Nucleotide PROPN I-LF
Polymorphism PROPN I-LF
Database PROPN I-LF
( PUNCT O
dbSNP PROPN B-AC
) PUNCT O
and/or CCONJ O
The DET B-LF
Exome PROPN I-LF
Aggregation PROPN I-LF
Consortium PROPN I-LF
( PUNCT O
ExAC PROPN B-AC
) PUNCT O
. PUNCT O

NPV NOUN B-AC
= PUNCT O
negative ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
. PUNCT O

GSH PROPN B-AC
depletion NOUN O
obtained VERB O
by ADP O
buthionine NOUN B-LF
sulfoximine NOUN I-LF
( PUNCT O
BSO PROPN B-AC
) PUNCT O
, PUNCT O
the DET O
irreversible ADJ O
inhibitor NOUN O
of ADP O
rGCS PROPN B-AC
, PUNCT O
is AUX O
the DET O
most ADV O
frequently ADV O
used VERB O
. PUNCT O

Our PRON O
study NOUN O
complied VERB O
with ADP O
the DET O
Declaration PROPN O
of ADP O
Helsinki PROPN O
adopted VERB O
by ADP O
the DET O
World PROPN B-LF
Medical PROPN I-LF
Association PROPN I-LF
( PUNCT O
WMA PROPN B-AC
) PUNCT O
in ADP O
1964 NUM O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
CCR PROPN B-AC
, PUNCT O
case NOUN B-LF
- ADJ I-LF
carrier NOUN I-LF
ratio NOUN I-LF
; PUNCT O
IPD PROPN B-AC
, PUNCT O
invasive ADJ B-LF
pneumococcal NOUN I-LF
disease NOUN I-LF
; PUNCT O
NVT PROPN B-AC
, PUNCT O
non ADJ O
- ADJ O
vaccine ADJ O
serotype NOUN O
group NOUN O
( PUNCT O
non ADJ O
- ADJ O
PCV13 ADJ B-AC
serotypes NOUN O
and CCONJ O
serotype NOUN O
3 NUM O
) PUNCT O
; PUNCT O
UI NOUN B-AC
, PUNCT O
uncertainty NOUN B-LF
interval NOUN I-LF
. PUNCT O

Third ADJ O
- PUNCT O
order NOUN O
femoral ADJ O
arteries NOUN O
( PUNCT O
internal ADJ O
diameter NOUN O
< ADP O
300μm NUM O
) PUNCT O
were AUX O
isolated VERB O
and CCONJ O
placed VERB O
in ADP O
physiologic ADJ B-LF
buffer NOUN I-LF
solution NOUN I-LF
( PUNCT O
PBS PROPN B-AC
) PUNCT O
. PUNCT O
A DET O
segment NOUN O
of ADP O
approximately ADV O
2 NUM O
mm NOUN O
in ADP O
length NOUN O
was AUX O
cut VERB O
and CCONJ O
threaded VERB O
with ADP O
two NUM O
40 NUM O
- PUNCT O
μm NOUN O
diameter NOUN O
stainless ADJ O
steel NOUN O
wires NOUN O
. PUNCT O

For ADP O
the DET O
entire ADJ O
study NOUN O
population NOUN O
( PUNCT O
ages NOUN O
0–64 NUM O
) PUNCT O
, PUNCT O
rate NOUN B-LF
ratios NOUN I-LF
( PUNCT O
RRs NOUN B-AC
) PUNCT O
were AUX O
calculated VERB O
by ADP O
counting VERB O
occurrences NOUN O
of ADP O
the DET O
outcomes NOUN O
of ADP O
interest NOUN O
during ADP O
the DET O
5 NUM O
- PUNCT O
day NOUN O
county NOUN O
- PUNCT O
wide ADJ O
exposed VERB O
periods NOUN O
P1 NOUN O
( PUNCT O
October PROPN O
22–26 NUM O
; PUNCT O
highest ADJ O
exposures NOUN O
) PUNCT O
, PUNCT O
P2 PROPN O
( PUNCT O
October PROPN O
27–31 NUM O
; PUNCT O
lower ADJ O
exposures NOUN O
and CCONJ O
lagged ADJ O
or CCONJ O
cumulative ADJ O
effects NOUN O
) PUNCT O
, PUNCT O
and CCONJ O
P3 PROPN O
( PUNCT O
November PROPN O
1–5 NUM O
; PUNCT O
lagged ADJ O
effects NOUN O
and CCONJ O
cumulative ADJ O
effects NOUN O
) PUNCT O
and CCONJ O
comparing VERB O
them PRON O
with ADP O
occurrences NOUN O
of ADP O
the DET O
same ADJ O
outcome NOUN O
during ADP O
six NUM O
5 NUM O
- PUNCT O
day NOUN O
comparison NOUN O
periods NOUN O
, PUNCT O
matched VERB O
on ADP O
day NOUN O
of ADP O
week NOUN O
( PUNCT O
5 NUM O
- PUNCT O
day NOUN O
periods NOUN O
starting VERB O
3 NUM O
, PUNCT O
4 NUM O
, PUNCT O
5 NUM O
, PUNCT O
6 NUM O
, PUNCT O
8 NUM O
, PUNCT O
and CCONJ O
9 NUM O
weeks NOUN O
before ADP O
each DET O
exposed VERB O
period NOUN O
; PUNCT O
weeks NOUN O
1 NUM O
and CCONJ O
2 NUM O
were AUX O
excluded VERB O
because SCONJ O
, PUNCT O
for ADP O
P2 PROPN O
and CCONJ O
P3 PROPN O
, PUNCT O
they PRON O
would AUX O
have AUX O
overlapped VERB O
with ADP O
P1 NOUN O
, PUNCT O
and CCONJ O
week NOUN O
7 NUM O
was AUX O
excluded VERB O
to ADP O
prevent VERB O
comparing VERB O
P1 NOUN O
to ADP O
the DET O
Labor PROPN O
Day PROPN O
holiday NOUN O
) PUNCT O
. PUNCT O

The DET O
three NUM O
combinations NOUN O
— PUNCT O
amodiaquine NOUN B-LF
( PUNCT O
AQ NOUN B-AC
) PUNCT O
and CCONJ O
sulfadoxine NOUN B-LF
- PUNCT I-LF
pyrimethamine NOUN I-LF
( PUNCT O
SP PROPN B-AC
) PUNCT O
; PUNCT O
AQ NOUN B-AC
and CCONJ O
artesunate NOUN B-LF
( PUNCT O
AS PROPN B-AC
) PUNCT O
; PUNCT O
and CCONJ O
artemether NOUN B-LF
- PUNCT I-LF
lumefantrine NOUN I-LF
( PUNCT O
AL)—were PROPN B-AC
used VERB O
to PART O
treat VERB O
Tanzanian ADJ O
children NOUN O
. PUNCT O

The DET O
aim NOUN O
of ADP O
the DET O
present ADJ O
study NOUN O
was AUX O
to PART O
assess VERB O
if SCONJ O
the DET O
last ADJ O
two NUM O
doses NOUN O
of ADP O
AQ PROPN B-AC
were AUX O
truly ADV O
administered VERB O
as SCONJ O
prescribed VERB O
by ADP O
the DET O
parents NOUN O
at ADP O
home NOUN O
based VERB O
on ADP O
drug NOUN O
level NOUN O
measurement NOUN O
and CCONJ O
PK NOUN B-LF
modelling NOUN O
, PUNCT O
which PRON O
is AUX O
a DET O
good ADJ O
proxy NOUN O
of ADP O
medication NOUN O
adherence NOUN O
and CCONJ O
an DET O
assessment NOUN O
of ADP O
the DET O
feasibility NOUN O
of ADP O
self NOUN O
- PUNCT O
administred VERB O
malaria NOUN O
preventive ADJ O
treatments NOUN O
. PUNCT O

In ADP O
all DET O
vertebrates NOUN O
, PUNCT O
the DET O
MLR PROPN B-AC
acts VERB O
as ADP O
a DET O
motor NOUN O
command NOUN O
center NOUN O
that PRON O
controls VERB O
locomotion NOUN O
via ADP O
descending VERB O
projections NOUN O
to ADP O
brainstem NOUN O
reticulospinal ADJ B-LF
( PUNCT O
RS PROPN B-AC
) PUNCT O
neurons NOUN O
[ PUNCT O
14–22 NUM O
] PUNCT O
. PUNCT O

Estimates NOUN O
were AUX O
reported VERB O
in ADP O
adjusted ADJ O
odds NOUN O
ratios NOUN O
with ADP O
95 NUM O
% NOUN O
confidence NOUN B-LF
intervals NOUN I-LF
( PUNCT O
CI NOUN B-AC
) PUNCT O
and CCONJ O
a DET O
significant ADJ O
association NOUN O
was AUX O
declared VERB O
at ADP O
p NOUN O
- PUNCT O
value NOUN O
of ADP O
less ADJ O
than ADP O
0.05 NUM O
. PUNCT O

Engagement NOUN O
of ADP O
PRRs NOUN B-AC
such ADJ O
as ADP O
Toll PROPN B-LF
- PUNCT I-LF
like ADJ I-LF
receptors NOUN I-LF
( PUNCT O
TLRs NOUN B-AC
) PUNCT O
and CCONJ O
C NOUN B-LF
- PUNCT I-LF
type NOUN I-LF
lectin NOUN I-LF
receptors NOUN I-LF
( PUNCT O
CLRs NOUN B-AC
) PUNCT O
leads VERB O
to ADP O
DC PROPN B-AC
activation NOUN O
, PUNCT O
characterized VERB O
with ADP O
up ADV O
- PUNCT O
regulated VERB O
capacities NOUN O
in ADP O
antigen NOUN O
presentation NOUN O
, PUNCT O
migration NOUN O
, PUNCT O
and CCONJ O
cytokine NOUN O
production NOUN O
. PUNCT O

Although SCONJ O
we PRON O
do AUX O
frequently ADV O
observe VERB O
H3K4me3 NOUN O
occupancy NOUN O
at ADP O
transcription NOUN B-LF
start NOUN I-LF
sites NOUN I-LF
( PUNCT O
TSSs PROPN B-AC
) PUNCT O
flanking VERB O
PH NOUN O
sites NOUN O
, PUNCT O
this PRON O
is AUX O
almost ADV O
exclusively ADV O
observed VERB O
at ADP O
the DET O
boundary NOUN O
of ADP O
large ADJ O
H3K27me3 NOUN O
domains NOUN O
( PUNCT O
see VERB O
Text NOUN O
S1 NOUN O
) PUNCT O
. PUNCT O

OSCN- PROPN O
, PUNCT O
hypothiocyanite NOUN O
; PUNCT O
OI- PROPN O
, PUNCT O
hypoiodite NOUN O
; PUNCT O
IAV PROPN B-AC
, PUNCT O
influenza NOUN B-LF
A NOUN I-LF
virus NOUN I-LF
; PUNCT O
IBV PROPN B-AC
, PUNCT O
influenza NOUN B-LF
B NOUN I-LF
virus NOUN I-LF
. PUNCT O

The DET O
Drosophila PROPN O
protein NOUN O
Cortex PROPN O
( PUNCT O
Cort PROPN O
) PUNCT O
is AUX O
a DET O
female ADJ O
, PUNCT O
meiosis NOUN O
- PUNCT O
specific ADJ O
activator NOUN O
of ADP O
the DET O
Anaphase PROPN B-LF
Promoting VERB I-LF
Complex PROPN I-LF
/ SYM I-LF
Cyclosome PROPN I-LF
( PUNCT O
APC PROPN B-AC
/ SYM B-AC
C PROPN B-AC
) PUNCT O
, PUNCT O
an DET O
E3 PROPN O
ubiquitin NOUN O
ligase NOUN O
. PUNCT O

The DET O
aims NOUN O
of ADP O
the DET O
Prenatal PROPN B-LF
Repeat PROPN I-LF
Corticosteroid PROPN I-LF
International PROPN I-LF
IPD PROPN I-LF
- PUNCT I-LF
MA PROPN I-LF
Study PROPN I-LF
: PUNCT I-LF
assessing VERB I-LF
the DET I-LF
effects NOUN I-LF
using VERB I-LF
the DET I-LF
best ADJ I-LF
level NOUN I-LF
of ADP I-LF
Evidence PROPN I-LF
( PUNCT O
PRECISE PROPN B-AC
) PUNCT O
individual ADJ B-LF
participant NOUN I-LF
data NOUN I-LF
meta NOUN B-LF
- PUNCT I-LF
analysis NOUN I-LF
( PUNCT O
IPD PROPN B-AC
- PUNCT O
MA PROPN B-AC
) PUNCT O
were AUX O
to ADP O
assess VERB O
the DET O
effect NOUN O
of ADP O
repeat NOUN O
prenatal ADJ O
corticosteroids NOUN O
when SCONJ O
given VERB O
to ADP O
women NOUN O
at ADP O
high ADJ O
, PUNCT O
ongoing ADJ O
risk NOUN O
of ADP O
preterm ADJ O
birth NOUN O
on ADP O
important ADJ O
clinical ADJ O
outcomes NOUN O
and CCONJ O
whether SCONJ O
treatment NOUN O
effects NOUN O
varied VERB O
depending VERB O
on ADP O
participant NOUN O
and CCONJ O
treatment NOUN O
factors NOUN O
. PUNCT O

PMI PROPN B-AC
, PUNCT O
prioritized VERB B-LF
memory NOUN I-LF
item NOUN I-LF
. PUNCT O

In ADP O
2012 NUM O
, PUNCT O
the DET O
Ministry PROPN B-LF
of ADP I-LF
Health PROPN I-LF
( PUNCT O
MOH PROPN B-AC
) PUNCT O
in ADP O
Zambia PROPN O
started VERB O
a DET O
national ADJ O
multi ADJ O
- ADJ O
disciplinary ADJ O
mentorship NOUN O
program NOUN O
. PUNCT O

Ten NUM O
communities NOUN O
included VERB O
algae NOUN O
only ADV O
( PUNCT O
A NOUN O
) PUNCT O
, PUNCT O
10 NUM O
comprised VERB O
algae NOUN O
+ CCONJ O
grazers NOUN O
( PUNCT O
AG NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
10 NUM O
included VERB O
algae NOUN O
+ CCONJ O
grazers NOUN O
+ CCONJ O
predators NOUN O
( PUNCT O
AGP NOUN B-AC
) PUNCT O
. PUNCT O
We PRON O
sampled VERB O
net ADJ O
ecosystem NOUN O
oxygen NOUN O
production NOUN O
( PUNCT O
NEP PROPN B-AC
) PUNCT O
, PUNCT O
ecosystem NOUN B-LF
respiration NOUN I-LF
( PUNCT O
ER NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
total ADJ O
phytoplankton NOUN O
biomass NOUN O
( PUNCT O
MB NOUN O
) PUNCT O
weekly ADV O
for ADP O
8 NUM O
weeks NOUN O
. PUNCT O

HR NOUN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT O
CI PROPN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
ID NOUN B-AC
, PUNCT O
intellectual ADJ B-LF
disability NOUN I-LF
; PUNCT O
HT PROPN O
, PUNCT O
hypothyroidism NOUN O
; PUNCT O
NHT NOUN O
, PUNCT O
no DET O
hypothyroidism NOUN O
; PUNCT O
INC PROPN O
, PUNCT O
household NOUN O
income NOUN O
. PUNCT O

The DET O
other ADJ O
two NUM O
studies NOUN O
determined VERB O
that SCONJ O
NRF2 PROPN B-AC
was AUX O
a DET O
good ADJ O
biomarker NOUN O
for ADP O
predicting VERB O
response NOUN O
to ADP O
EGFR PROPN B-AC
- PUNCT B-AC
TKI PROPN B-AC
( PUNCT O
Epidermal ADJ B-LF
growth NOUN I-LF
factor NOUN I-LF
receptor NOUN I-LF
tyrosine NOUN I-LF
kinase NOUN I-LF
inhibitor NOUN I-LF
) PUNCT O
in ADP O
patients NOUN O
with ADP O
EGFR PROPN O
gene NOUN O
mutations NOUN O
. PUNCT O

In ADP O
an DET O
attempt NOUN O
to PART O
control VERB O
an DET O
epidemic NOUN O
of ADP O
ovine ADJ B-LF
Johne PROPN I-LF
’s PART I-LF
disease NOUN I-LF
( PUNCT O
OJD PROPN B-AC
) PUNCT O
in ADP O
New PROPN B-LF
South PROPN I-LF
Wales PROPN I-LF
( PUNCT O
NSW PROPN B-AC
) PUNCT O
, PUNCT O
a DET O
government NOUN O
/ SYM O
industry NOUN O
sponsored VERB O
voluntary ADJ O
vaccination NOUN O
/ SYM O
on ADP O
- PUNCT O
farm NOUN O
management NOUN O
program NOUN O
commenced VERB O
in ADP O
2000 NUM O
. PUNCT O

In ADP O
humans NOUN O
, PUNCT O
contrary ADJ O
to ADP O
natural ADJ B-LF
killer NOUN I-LF
T PROPN I-LF
( PUNCT O
NKT PROPN B-AC
) PUNCT O
cells NOUN O
, PUNCT O
MAIT PROPN B-AC
cells NOUN O
display VERB O
a DET O
naïve ADJ O
phenotype NOUN O
in ADP O
the DET O
thymus NOUN O
as ADP O
well ADV O
as ADP O
in ADP O
cord NOUN O
blood NOUN O
where SCONJ O
they PRON O
are AUX O
in ADP O
low ADJ O
numbers NOUN O
. PUNCT O

PM2.5 NOUN B-AC
, PUNCT O
fine ADJ B-LF
particulate NOUN I-LF
matter NOUN I-LF
( PUNCT O
particulate NOUN O
matter NOUN O
with ADP O
a DET O
diameter NOUN O
of ADP O
< ADP O
2.5 NUM O
μm NOUN O
) PUNCT O
; PUNCT O
SD NOUN B-AC
, PUNCT O
standard ADJ B-LF
deviation NOUN I-LF

Intra ADJ B-LF
- ADJ I-LF
cluster NOUN I-LF
correlation NOUN I-LF
coefficients NOUN I-LF
( PUNCT O
ICCs NOUN B-AC
) PUNCT O
were AUX O
calculated VERB O
for ADP O
each DET O
outcome NOUN O
. PUNCT O

ICU PROPN B-AC
, PUNCT O
Intensive PROPN B-LF
Care PROPN I-LF
Unit PROPN I-LF
; PUNCT O
IMCU PROPN B-AC
, PUNCT O
Intermediate PROPN B-LF
Care PROPN I-LF
Unit PROPN I-LF
; PUNCT O
LSC PROPN B-AC
, PUNCT O
Life PROPN B-LF
Supporting PROPN I-LF
Care PROPN I-LF
; PUNCT O
LSC PROPN B-AC
- PUNCT B-AC
L PROPN B-AC
, PUNCT O
Life PROPN B-LF
Supporting PROPN I-LF
Care PROPN I-LF
Limitation PROPN I-LF
; PUNCT O
SAPS PROPN B-AC
II NUM B-AC
, PUNCT O
Simplified PROPN B-LF
Acute PROPN I-LF
Physiology PROPN I-LF
Score PROPN I-LF
; PUNCT O
SOFA PROPN B-AC
, PUNCT O
Sequential PROPN B-LF
Organ PROPN I-LF
failure PROPN I-LF
Assessment PROPN I-LF
; PUNCT O
LOS PROPN B-AC
, PUNCT O
Length NOUN B-LF
of ADP I-LF
stay NOUN I-LF
. PUNCT O

OCT-4 PROPN O
, PUNCT O
octamer NOUN O
- PUNCT O
binding VERB O
transcription NOUN O
factor-4 NOUN O
; PUNCT O
Sox-2 PROPN B-AC
, PUNCT O
SRY PROPN B-LF
( PUNCT I-LF
sex NOUN I-LF
determining VERB I-LF
region NOUN I-LF
Y)-box NOUN I-LF
2 NUM I-LF
; PUNCT O
Nanog PROPN B-AC
, PUNCT O
Nanog PROPN B-LF
homeobox NOUN I-LF
; PUNCT O
TRA-1 PROPN B-AC
- PUNCT B-AC
60 NUM B-AC
, PUNCT O
podocalyxin NOUN B-LF
; PUNCT O
ZO-1 PROPN B-AC
, PUNCT O
zonula NOUN O
occludens NOUN O
1 NUM O
; PUNCT O
RPE65 PROPN B-AC
, PUNCT O
Retinal ADJ O
pigment NOUN O
epithelium NOUN O
- PUNCT O
specific ADJ O
65 NUM O
kDa NOUN O
protein NOUN O
; PUNCT O
Na PROPN O
+ SYM O
/K SYM O
+ SYM O
ATPase PROPN O
, PUNCT O
sodium NOUN O
- PUNCT O
potassium NOUN O
adenosine NOUN O
triphosphatase NOUN O
; PUNCT O
RPE PROPN B-AC
cell NOUN O
, PUNCT O
retinal ADJ O
pigment NOUN O
epithelial ADJ O
cell NOUN O

ω NOUN B-LF
- NOUN I-LF
conotoxin NOUN I-LF
MVIIC PROPN I-LF

Black ADJ O
dots NOUN O
indicate VERB O
that SCONJ O
the DET O
estimate NOUN O
had VERB O
a DET O
p NOUN O
- PUNCT O
value NOUN O
< ADP O
0.05 NUM O
; PUNCT O
white ADJ O
dots NOUN O
indicate VERB O
a DET O
p NOUN O
- PUNCT O
value NOUN O
≥ ADP O
0.05 NUM O
. PUNCT O
8 NUM O
- PUNCT O
OHDG PROPN O
: PUNCT O
8 NUM O
- PUNCT O
hydroxy-2′-deoxyguanosine NOUN O
; PUNCT O
B PROPN O
, PUNCT O
baseline NOUN O
; PUNCT O
BPA PROPN B-AC
, PUNCT O
bisphenol NOUN B-LF
A NOUN I-LF
; PUNCT O
DEHP PROPN B-AC
, PUNCT O
di(2 NOUN B-LF
- PUNCT I-LF
ethylhexyl NOUN I-LF
) PUNCT I-LF
phthalate NOUN I-LF
; PUNCT O
DOP PROPN B-AC
, PUNCT O
di NOUN B-LF
- PUNCT I-LF
n NOUN I-LF
- PUNCT I-LF
octyl NOUN I-LF
phthalate NOUN I-LF
; PUNCT O
HMW PROPN B-AC
, PUNCT O
high ADJ B-LF
molecular ADJ I-LF
weight NOUN I-LF
phthalates NOUN O
; PUNCT O
LMW PROPN B-AC
, PUNCT O
low ADJ B-LF
molecular ADJ I-LF
weight NOUN I-LF
phthalates NOUN O
; PUNCT O
PA PROPN B-AC
, PUNCT O
phthalic ADJ B-LF
acid NOUN I-LF
; PUNCT O
Y[number NOUN O
] PUNCT O
, PUNCT O
year NOUN O
[ X O
number NOUN O
] PUNCT O
. PUNCT O

We PRON O
also ADV O
analyzed VERB O
how SCONJ O
obesity NOUN O
related VERB O
to ADP O
LFAT NOUN B-AC
measured VERB O
by ADP O
1H NOUN B-AC
- PUNCT B-AC
MRS NOUN B-AC
in ADP O
79 NUM O
Finns PROPN O
and CCONJ O
118 NUM O
Chinese PROPN O
with ADP O
type NOUN B-LF
2 NUM I-LF
diabetes NOUN I-LF
( PUNCT O
T2D NOUN B-AC
) PUNCT O
. PUNCT O

ART PROPN B-AC
, PUNCT O
antiretroviral ADJ B-LF
therapy NOUN I-LF
; PUNCT O
BMI PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
Hb NOUN B-AC
, PUNCT O
haemoglobin NOUN B-LF
concentration NOUN I-LF
; PUNCT O
LAM PROPN B-AC
, PUNCT O
lipoarabinomannan NOUN B-LF
assay NOUN I-LF
; PUNCT O
MTB NOUN B-AC
, PUNCT O
Mycobacterium NOUN B-LF
tuberculosis NOUN I-LF
; PUNCT O
TB PROPN B-AC
, PUNCT O
tuberculosis NOUN B-LF
. PUNCT O

Table NOUN O
2 NUM O
shows VERB O
the DET O
identified VERB O
loci NOUN O
with ADP O
a DET O
logarithm NOUN B-LF
of ADP I-LF
the DET I-LF
odds NOUN I-LF
( PUNCT O
LOD PROPN B-AC
) PUNCT O
score NOUN O
> SYM O
2 NUM O
in ADP O
the DET O
total ADJ O
cohort NOUN O
, PUNCT O
and CCONJ O
in ADP O
sex NOUN O
/ SYM O
twin NOUN O
specific ADJ O
analyses NOUN O
. PUNCT O

Substrate NOUN O
glycerol NOUN O
and CCONJ O
the DET O
products NOUN O
PDO NOUN B-AC
, PUNCT O
butyric ADJ O
acid NOUN O
, PUNCT O
acetic ADJ O
acid NOUN O
, PUNCT O
lactic ADJ O
acid NOUN O
, PUNCT O
and CCONJ O
butanol NOUN O
were AUX O
quantified VERB O
using VERB O
ultra ADJ B-LF
- ADJ I-LF
fast ADJ I-LF
liquid NOUN I-LF
chromatography NOUN I-LF
( PUNCT O
UFLC PROPN B-AC
) PUNCT O
with ADP O
a DET O
refractive ADJ O
index NOUN O
detector NOUN O
( PUNCT O
Shimadzu PROPN O
RID PROPN O
10A PROPN O
) PUNCT O
at ADP O
60 NUM O
° NOUN O
C NOUN O
and CCONJ O
AMINEX PROPN O
HPX PROPN O
— PUNCT O
87H NUM O
column NOUN O
( PUNCT O
Biorad PROPN O
) PUNCT O
at ADP O
63 NUM O
° NOUN O
C NOUN O
, PUNCT O
a DET O
solution NOUN O
of ADP O
3 NUM O
mM NOUN O
of ADP O
sulfuric ADJ O
acid NOUN O
as ADP O
the DET O
phase NOUN O
mobile NOUN O
, PUNCT O
and CCONJ O
0.5 NUM O
mL NOUN O
/ SYM O
min NOUN O
flow NOUN O
during ADP O
45 NUM O
minutes NOUN O
of ADP O
run NOUN O
time NOUN O
. PUNCT O

This DET O
palmitoylation NOUN O
site NOUN O
is AUX O
located VERB O
within ADP O
the DET O
isoform NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
targeting NOUN I-LF
and CCONJ I-LF
interaction NOUN I-LF
domain NOUN I-LF
( PUNCT O
ISTID PROPN B-AC
) PUNCT O
of ADP O
Nmnat2 PROPN O
. PUNCT O

Therefore ADV O
, PUNCT O
the DET O
findings NOUN O
of ADP O
the DET O
previous ADJ O
study NOUN O
[ PUNCT O
31 NUM O
] PUNCT O
do AUX O
not PART O
allow VERB O
the DET O
general ADJ O
conclusion NOUN O
that PRON O
M1 PROPN B-AC
plasticity NOUN O
is AUX O
normal ADJ O
in ADP O
ET PROPN B-AC
. PUNCT O
Another DET O
study NOUN O
that PRON O
applied VERB O
continuous ADJ O
theta NOUN O
- PUNCT O
burst NOUN O
stimulation NOUN O
, PUNCT O
a DET O
protocol NOUN O
that PRON O
in ADP O
healthy ADJ O
subjects NOUN O
leads VERB O
to ADP O
a DET O
long ADJ B-LF
- PUNCT I-LF
term NOUN I-LF
depression NOUN I-LF
( PUNCT O
LTD)-like PROPN B-AC
decrease NOUN O
in ADP O
MEP PROPN B-AC
amplitude NOUN O
[ PUNCT O
34 NUM O
] PUNCT O
, PUNCT O
demonstrated VERB O
a DET O
lack NOUN O
of ADP O
this DET O
type NOUN O
of ADP O
LTD NOUN B-AC
- PUNCT O
like ADJ O
plasticity NOUN O
in ADP O
ET PROPN B-AC
patients NOUN O
[ PUNCT O
35 NUM O
] PUNCT O
. PUNCT O

In ADP O
this DET O
study NOUN O
, PUNCT O
we PRON O
identify VERB O
the DET O
transcription NOUN O
factor NOUN O
Promyelocytic PROPN B-LF
Leukemia PROPN I-LF
Zinc PROPN I-LF
Finger PROPN I-LF
( PUNCT O
PLZF PROPN B-AC
) PUNCT O
as ADP O
a DET O
critical ADJ O
regulator NOUN O
of ADP O
this DET O
process NOUN O
in ADP O
the DET O
chick NOUN O
spinal NOUN O
cord NOUN O
. PUNCT O

CD NOUN B-AC
, PUNCT O
cluster NOUN B-LF
of ADP I-LF
differentiation NOUN I-LF
; PUNCT O
CSC PROPN B-AC
, PUNCT O
cancer NOUN B-LF
stem NOUN I-LF
cell NOUN I-LF
; PUNCT O
GD2 PROPN B-AC
: PUNCT O
disialoganglioside NOUN B-LF
; PUNCT O
NB PROPN B-AC
, PUNCT O
neuroblastoma NOUN B-LF
; PUNCT O
NK PROPN B-AC
, PUNCT O
natural ADJ B-LF
killer NOUN I-LF
; PUNCT O
pDC NOUN B-AC
, PUNCT O
plasmacytoid NOUN B-LF
dendritic ADJ I-LF
cell NOUN I-LF
; PUNCT O
TLR PROPN B-AC
, PUNCT O
toll NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
receptor NOUN I-LF
. PUNCT O

Focusing VERB O
on ADP O
the DET O
endometrium NOUN O
during ADP O
the DET O
implantation NOUN O
phase NOUN O
, PUNCT O
the DET O
mesenchymal NOUN B-LF
- PUNCT I-LF
epithelial NOUN I-LF
transition NOUN I-LF
( PUNCT O
MET PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
is AUX O
the DET O
reverse ADJ O
process NOUN O
to ADP O
the DET O
EMT NOUN B-AC
, PUNCT O
is AUX O
induced VERB O
in ADP O
the DET O
endometrium NOUN O
and CCONJ O
promotes VERB O
the DET O
acceptance NOUN O
of ADP O
embryos NOUN O
to ADP O
the DET O
uterus NOUN O
[ PUNCT O
20 NUM O
, PUNCT O
21 NUM O
] PUNCT O
. PUNCT O

We PRON O
examined VERB O
all DET B-LF
- ADJ I-LF
cause NOUN I-LF
mortality NOUN I-LF
( PUNCT O
ACM PROPN B-AC
) PUNCT O
, PUNCT O
drug NOUN B-LF
- ADJ I-LF
related VERB I-LF
poisoning NOUN I-LF
( PUNCT O
DRP NOUN B-AC
) PUNCT O
mortality NOUN O
, PUNCT O
and CCONJ O
mortality NOUN O
not PART O
attributable ADJ O
to ADP O
DRP NOUN B-AC
( PUNCT O
non ADJ O
- ADJ O
DRP NOUN B-AC
) PUNCT O
. PUNCT O
Models NOUN O
included VERB O
potential ADJ O
confounding VERB O
factors NOUN O
. PUNCT O

This PRON O
was AUX O
a DET O
cross ADJ O
- PUNCT O
sectional ADJ O
study NOUN O
which PRON O
used VERB O
data NOUN O
from ADP O
the DET O
2015 NUM O
Mozambique PROPN O
Global PROPN B-LF
School PROPN I-LF
- PUNCT I-LF
based VERB I-LF
Health PROPN I-LF
Survey PROPN I-LF
( PUNCT O
GSHS PROPN B-AC
) PUNCT O
collected VERB O
using VERB O
a DET O
clustered VERB O
sample NOUN O
design NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
AA PROPN B-AC
, PUNCT O
artesunate NOUN B-LF
- PUNCT I-LF
amodiaquine NOUN I-LF
; PUNCT O
AL PROPN B-AC
, PUNCT O
artemether NOUN B-LF
- PUNCT I-LF
lumefantrine NOUN I-LF
; PUNCT O
AM PROPN B-AC
, PUNCT O
artesunate NOUN B-LF
- PUNCT I-LF
mefloquine NOUN I-LF
; PUNCT O
DP PROPN B-AC
, PUNCT O
dihydroartemisinin NOUN B-LF
- PUNCT I-LF
piperaquine NOUN I-LF
; PUNCT O
Hb NOUN B-AC
, PUNCT O
haemoglobin NOUN B-LF
; PUNCT O
IQR NOUN B-AC
, PUNCT O
interquartile ADJ B-LF
range NOUN I-LF
; PUNCT O
n NOUN O
, PUNCT O
number NOUN O
; PUNCT O
SD NOUN O
, PUNCT O
standard ADJ O
deviation NOUN O
. PUNCT O

This DET O
context NOUN O
of ADP O
T PROPN O
cells NOUN O
within ADP O
the DET O
tumor NOUN O
, PUNCT O
tumor NOUN B-LF
- PUNCT I-LF
infiltrating VERB I-LF
lymphocytes NOUN I-LF
( PUNCT O
TILs PROPN B-AC
) PUNCT O
, PUNCT O
as ADP O
well ADV O
as ADP O
immune ADJ O
cells NOUN O
in ADP O
the DET O
surrounding VERB O
stroma NOUN O
, PUNCT O
which PRON O
can AUX O
include VERB O
a DET O
pathologic ADJ O
feature NOUN O
called VERB O
“ PUNCT O
Crohn’s PROPN B-LF
- PUNCT I-LF
like ADJ I-LF
Lymphoid PROPN I-LF
Reaction PROPN I-LF
” PUNCT O
( PUNCT O
CLR PROPN B-AC
) PUNCT O
, PUNCT O
include VERB O
a DET O
mix NOUN O
of ADP O
T PROPN O
cells NOUN O
and CCONJ O
B NOUN O
cells NOUN O
. PUNCT O

( PUNCT O
A X O
, PUNCT O
B X O
) PUNCT O
Fitness NOUN O
advantage NOUN O
of ADP O
lys−orgS− NOUN B-AC
over ADP O
lys− NOUN O
requires VERB O
low ADJ O
organosulfur NOUN B-LF
and CCONJ O
autophagy NOUN O
. PUNCT O

Data NOUN O
are AUX O
representative ADJ O
of ADP O
two NUM O
independent ADJ O
experiments NOUN O
. PUNCT O
aTreg PROPN B-AC
, PUNCT O
activated VERB B-LF
Treg PROPN I-LF
; PUNCT O
IL PROPN B-AC
, PUNCT O
interleukin NOUN B-LF
; PUNCT O
Ki-67 NOUN B-AC
, PUNCT O
antigen NOUN B-LF
identified VERB I-LF
by ADP I-LF
monoclonal ADJ I-LF
antibody NOUN I-LF
Ki PROPN I-LF
67 NUM I-LF
; PUNCT O
rTreg NOUN B-AC
, PUNCT O
resting VERB B-LF
Treg PROPN I-LF
. PUNCT O

CanR PROPN O
, PUNCT O
canavanine NOUN O
- PUNCT O
resistant ADJ O
; PUNCT O
dsDNA NOUN B-AC
, PUNCT O
double ADV B-LF
- PUNCT I-LF
stranded VERB I-LF
DNA NOUN I-LF
. PUNCT O

The DET O
supernatant NOUN O
were AUX O
obtained VERB O
for ADP O
total ADJ B-LF
cholesterol NOUN I-LF
( ADP O
TC PROPN B-AC
) PUNCT O
and CCONJ O
triglyceride NOUN B-LF
( ADP O
TG NOUN B-AC
) PUNCT O
analysis NOUN O
( ADP O
individually ADV O
20~30 NUM O
μL NOUN O
) PUNCT O
. PUNCT O
Aliquots NOUN O
of ADP O
plasma NOUN O
samples NOUN O
( ADP O
> ADP O
25 NUM O
μL NOUN O
) PUNCT O
were AUX O
obtained VERB O
for ADP O
insulin NOUN O
, PUNCT O
leptin NOUN O
, PUNCT O
and CCONJ O
adiponectin NOUN O
. PUNCT O

FPP NOUN B-AC
, PUNCT O
farnesyl NOUN B-LF
pyrophosphate NOUN I-LF
; PUNCT O
PI PROPN B-AC
, PUNCT O
propidium NOUN B-LF
iodide NOUN I-LF
. PUNCT O

Bleeding VERB B-LF
on ADP I-LF
probing VERB I-LF
( PUNCT O
BOP NOUN B-AC
) PUNCT O
is AUX O
a DET O
diagnostic ADJ O
criterion NOUN O
of ADP O
gingival ADJ O
inflammation NOUN O
. PUNCT O

Down PROPN B-LF
syndrome PROPN I-LF
( PUNCT O
DS PROPN B-AC
) PUNCT O
is AUX O
the DET O
most ADV O
common ADJ O
genetic ADJ O
cause NOUN O
of ADP O
intellectual ADJ O
disability NOUN O
, PUNCT O
and CCONJ O
arises VERB O
from ADP O
the DET O
presence NOUN O
of ADP O
an DET O
extra ADJ O
copy NOUN O
of ADP O
human ADJ B-LF
chromosome NOUN I-LF
21 NUM I-LF
( PUNCT O
Hsa21 NOUN B-AC
) PUNCT O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

Underlying VERB O
data NOUN O
are AUX O
provided VERB O
in ADP O
S1 PROPN O
Data PROPN O
. PUNCT O
( PUNCT O
G PROPN O
) PUNCT O
Transverse ADJ O
sections NOUN O
of ADP O
the DET O
NT PROPN B-AC
transfected VERB O
at ADP O
E2 NOUN O
with ADP O
ΔMaml1 PROPN B-AC
and CCONJ O
harvested VERB O
at ADP O
E3 PROPN O
. PUNCT O
Adjacent ADJ O
sections NOUN O
were AUX O
used VERB O
to ADP O
visualize VERB O
electroporation NOUN O
efficiency NOUN O
with ADP O
GFP PROPN B-AC
expression NOUN O
and CCONJ O
to ADP O
reveal VERB O
hΔMaml1 NOUN O
expression NOUN O
by ADP O
in ADP O
situ NOUN O
hybridization NOUN O
. PUNCT O
+ NOUN O
indicates VERB O
the DET O
electroporated VERB O
side NOUN O
of ADP O
the DET O
NT PROPN B-AC
. PUNCT O
Scale NOUN O
bar NOUN O
represents VERB O
50 NUM O
μm NOUN O
( PUNCT O
A PROPN O
– SYM O
B PROPN O
, PUNCT O
D PROPN O
, PUNCT O
F PROPN O
– SYM O
G PROPN O
) PUNCT O
or CCONJ O
25 NUM O
μm NOUN O
( PUNCT O
C PROPN O
, PUNCT O
E PROPN O
) PUNCT O
. PUNCT O
ΔMaml1 PROPN B-AC
, PUNCT O
dominant ADJ B-LF
- PUNCT I-LF
negative ADJ I-LF
Mastermind PROPN I-LF
- PUNCT I-LF
like PROPN I-LF
1 NUM I-LF
; PUNCT O
E PROPN O
, PUNCT O
embryonic ADJ O
day NOUN O
; PUNCT O
EdU PROPN B-AC
, PUNCT O
5 NUM B-LF
- PUNCT I-LF
ethynyl-2′-deoxyuridine NOUN I-LF
; PUNCT O
GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
H2B PROPN B-AC
- PUNCT O
iRFP PROPN B-AC
, PUNCT O
Histone NOUN B-LF
2B NUM I-LF
fused VERB O
to ADP O
infrared ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
hae NOUN B-AC
, PUNCT O
hour NOUN B-LF
after ADP I-LF
electroporation NOUN I-LF
; PUNCT O
Hes5 PROPN B-AC
, PUNCT O
Hairy PROPN B-LF
and CCONJ I-LF
Enhancer PROPN I-LF
of ADP I-LF
Split PROPN I-LF
5 NUM I-LF
; PUNCT O
HuCD PROPN B-AC
, PUNCT O
neuron NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
RNA NOUN I-LF
- PUNCT I-LF
binding VERB I-LF
proteins NOUN I-LF
HuC PROPN I-LF
and CCONJ I-LF
HuD PROPN I-LF
; PUNCT O
iRFP PROPN B-AC
, PUNCT O
infrared ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
Neurog2 PROPN B-AC
, PUNCT O
Neurogenin PROPN B-LF
2 NUM I-LF
; PUNCT O
ns NOUN O
, PUNCT O
nonsignificant ADJ O
; PUNCT O
NT PROPN B-AC
, PUNCT O
neural ADJ B-LF
tube NOUN I-LF
; PUNCT O
Pax6 PROPN B-AC
, PUNCT O
Paired ADJ B-LF
box NOUN I-LF
gene NOUN I-LF
6 NUM I-LF
; PUNCT O
VNP PROPN B-AC
, PUNCT O
Venus PROPN B-LF
- PUNCT I-LF
NLS PROPN I-LF
- PUNCT I-LF
PEST PROPN I-LF
. PUNCT O

PubMed PROPN O
was AUX O
searched VERB O
by ADP O
combining VERB O
two NUM O
separate ADJ O
queries NOUN O
composed VERB O
of ADP O
medical ADJ B-LF
subject NOUN I-LF
heading NOUN I-LF
( PUNCT O
MeSH PROPN B-AC
) PUNCT O
and CCONJ O
text NOUN B-LF
word NOUN I-LF
( PUNCT O
tw NOUN B-AC
) PUNCT O
keywords NOUN O
for ADP O
the DET O
exposure NOUN O
and CCONJ O
outcome NOUN O
of ADP O
interest NOUN O
. PUNCT O

The DET O
number NOUN O
of ADP O
ADL PROPN B-AC
and CCONJ O
IADL PROPN B-AC
dependencies NOUN O
were AUX O
summed VERB O
up ADP O
separately ADV O
to PART O
indicate VERB O
the DET O
self NOUN O
- PUNCT O
care NOUN O
impairment NOUN O
scores NOUN O
for ADP O
the DET O
PWD PROPN B-AC
. PUNCT O
The DET O
memory NOUN O
and CCONJ O
behavior NOUN O
problems NOUN O
of ADP O
PWD PROPN B-AC
were AUX O
measured VERB O
by ADP O
the DET B-LF
Revised PROPN I-LF
Memory PROPN I-LF
and CCONJ I-LF
Behaviour PROPN I-LF
Problems PROPN I-LF
Checklist PROPN I-LF
( PUNCT O
RMBPC PROPN B-AC
) PUNCT O
[ PUNCT O
27 NUM O
] PUNCT O
. PUNCT O

Molecular ADJ O
tests NOUN O
for ADP O
IDH1 NOUN B-AC
- NOUN B-AC
2 NUM B-AC
wild ADJ O
type NOUN O
( PUNCT O
isocitrate NOUN B-LF
dehydrogenase NOUN I-LF
type NOUN I-LF
1 NUM I-LF
and CCONJ I-LF
2 NUM I-LF
) PUNCT O
, PUNCT O
MGMT NOUN B-AC
( PUNCT O
O6 NOUN B-LF
- NOUN I-LF
Methylguanine NOUN I-LF
- NOUN I-LF
DNA NOUN I-LF
methyl NOUN I-LF
transferase NOUN I-LF
) PUNCT O
non ADJ O
- NOUN O
methylated VERB O
, PUNCT O
but CCONJ O
not PART O
1p/19q NOUN O
co NOUN O
- NOUN O
deletion NOUN O
were AUX O
included VERB O
( PUNCT O
Fig PROPN O
1 NUM O
) PUNCT O
. PUNCT O

Finally ADV O
, PUNCT O
the DET O
column NOUN O
- ADJ O
wise ADJ O
sum NOUN O
is AUX O
computed VERB O
using VERB O
the DET O
R NOUN O
matrix NOUN O
, PUNCT O
and CCONJ O
a DET O
threshold NOUN O
is AUX O
applied VERB O
to PART O
determine VERB O
the DET O
outer ADJ B-LF
pericarp NOUN I-LF
diameter NOUN I-LF
( PUNCT O
OPD NOUN B-AC
) PUNCT O
. PUNCT O
This DET O
approach NOUN O
allows VERB O
the DET O
estimation NOUN O
of ADP O
an DET O
average ADJ O
OPD NOUN B-AC
across ADP O
all DET O
the DET O
radial ADJ O
points NOUN O
of ADP O
the DET O
stamp NOUN O
, PUNCT O
which PRON O
can AUX O
be AUX O
extremely ADV O
useful ADJ O
when SCONJ O
non ADJ O
- ADJ O
symmetric ADJ O
fruit NOUN O
stamps NOUN O
are AUX O
measured VERB O
. PUNCT O

Tissue NOUN O
culture NOUN O
infectious ADJ O
dose NOUN O
50 NUM O
% NOUN O
( PUNCT O
TCID50 PROPN O
) PUNCT O
was AUX O
determined VERB O
by ADP O
end NOUN B-LF
- ADJ I-LF
point NOUN I-LF
dilution NOUN I-LF
assays NOUN I-LF
( PUNCT O
EPDA PROPN B-AC
) PUNCT O
. PUNCT O
Serial ADJ O
10 NUM O
- ADJ O
fold ADJ O
dilutions NOUN O
of ADP O
virus NOUN O
stocks NOUN O
and CCONJ O
experimental ADJ O
samples NOUN O
were AUX O
prepared VERB O
in ADP O
complete ADJ O
DMEM PROPN B-AC
cell NOUN O
culture NOUN O
medium NOUN O
. PUNCT O

The DET O
RWC PROPN B-AC
analysis NOUN O
was AUX O
performed VERB O
on ADP O
10 NUM O
days NOUN B-LF
after ADP I-LF
sowing NOUN I-LF
( PUNCT O
DAS NOUN B-AC
) PUNCT O
under ADP O
control NOUN B-LF
growth NOUN I-LF
( PUNCT O
CG PROPN B-AC
) PUNCT O
, PUNCT O
25 NUM O
DAS NOUN B-AC
under ADP O
drought NOUN O
stress NOUN O
and CCONJ O
on ADP O
38 NUM O
DAS NOUN B-AC
under ADP O
re NOUN O
- NOUN O
watering NOUN O
. PUNCT O

The DET O
human ADJ O
GAIT PROPN O
complex NOUN O
is AUX O
heterotetrameric NOUN O
containing VERB O
glutamyl NOUN B-LF
- NOUN I-LF
prolyl NOUN I-LF
- NOUN I-LF
tRNA NOUN I-LF
synthetase NOUN I-LF
( PUNCT O
EPRS PROPN B-AC
) PUNCT O
, PUNCT O
ribosomal ADJ O
protein NOUN O
L13a NOUN O
, PUNCT O
NS1 NOUN O
- NOUN O
associated VERB O
protein–1 NOUN O
, PUNCT O
and CCONJ O
glyceraldehyde NOUN B-LF
3 NUM I-LF
- NOUN I-LF
phosphate NOUN I-LF
dehydrogenase NOUN I-LF
( PUNCT O
GAPDH PROPN B-AC
) PUNCT O
[ PUNCT O
11],[12 NUM O
] PUNCT O
. PUNCT O

GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
. PUNCT O

CAPs NOUN B-AC
= PUNCT O
Compound ADJ B-LF
action NOUN I-LF
potential ADJ I-LF
recordings NOUN O
immediately ADV O
post ADV O
- ADJ O
operatively ADV O
. PUNCT O

Summary NOUN O
statistics NOUN O
for ADP O
16 NUM O
CVD NOUN B-AC
outcomes NOUN O
from ADP O
the DET O
Medical PROPN B-LF
Research PROPN I-LF
Council PROPN I-LF
Integrative PROPN I-LF
Epidemiology PROPN I-LF
Unit PROPN I-LF
( PUNCT O
MRC PROPN B-AC
- PUNCT B-AC
IEU PROPN B-AC
) PUNCT O
UKB PROPN B-AC
GWAS PROPN B-AC
Pipeline PROPN O
[ X O
41 NUM O
] X O
( PUNCT O
generated VERB O
using VERB O
the DET O
PHEnome PROPN B-LF
Scan PROPN I-LF
Analysis PROPN I-LF
Tool PROPN I-LF
( PUNCT O
PHESANT PROPN B-AC
) PUNCT O
[ X O
42 NUM O
] X O
) PUNCT O
and CCONJ O
the DET O
Neale PROPN O
Lab PROPN O
UKB PROPN B-AC
GWAS PROPN B-AC
[ X O
36 NUM O
] X O
are AUX O
listed VERB O
in ADP O
S1 PROPN O
Table PROPN O
. PUNCT O

The DET B-LF
Federal PROPN I-LF
Office PROPN I-LF
of ADP I-LF
Public PROPN I-LF
Health PROPN I-LF
( PUNCT O
FOPH PROPN B-AC
) PUNCT O
will AUX O
define VERB O
which DET O
QIs NOUN B-AC
will AUX O
be AUX O
collected VERB O
at ADP O
the DET O
national ADJ O
level NOUN O
in ADP O
near ADJ O
future NOUN O
. PUNCT O

Blocking NOUN O
and CCONJ O
antibody NOUN O
application NOUN O
were AUX O
as ADP O
above ADV O
except SCONJ O
the DET O
reaction NOUN O
product NOUN O
was AUX O
visualized VERB O
with ADP O
a DET O
diaminobenzidine NOUN B-LF
( PUNCT O
DAB PROPN B-AC
) PUNCT O
peroxidase NOUN O
substrate NOUN O
( PUNCT O
Vector PROPN O
Laboratories PROPN O
, PUNCT O
Burlingame PROPN O
, PUNCT O
CA PROPN O
) PUNCT O
, PUNCT O
counterstained VERB O
with ADP O
1 NUM O
% NOUN O
Cresyl PROPN O
Violet PROPN O
( PUNCT O
Sigma PROPN O
, PUNCT O
St. PROPN O
Louis PROPN O
, PUNCT O
MO PROPN O
) PUNCT O
, PUNCT O
and CCONJ O
cover NOUN O
- PUNCT O
slipped VERB O
with ADP O
Permount PROPN O
( PUNCT O
Fisher PROPN O
Scientific PROPN O
, PUNCT O
Waltham PROPN O
, PUNCT O
MA PROPN O
) PUNCT O
. PUNCT O

Laser PROPN B-LF
Doppler PROPN I-LF
flare NOUN I-LF
imaging NOUN I-LF
( PUNCT O
LDIFlare PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
quantitative ADJ B-LF
thermal ADJ I-LF
testing NOUN I-LF
( PUNCT O
QTT PROPN B-AC
) PUNCT O
are AUX O
non ADJ O
- ADJ O
invasive ADJ O
small ADJ O
fiber NOUN O
testing NOUN O
modalities NOUN O
, PUNCT O
measuring VERB O
small ADJ O
nerve NOUN O
fiber NOUN O
function NOUN O
, PUNCT O
enabling VERB O
objective ADJ O
confirmation NOUN O
of ADP O
small ADJ O
fiber NOUN O
neuropathy NOUN O
. PUNCT O

Macrophages NOUN O
were AUX O
pretreated VERB O
with ADP O
buffer NOUN O
, PUNCT O
neutralizing VERB O
antibodies NOUN O
against ADP O
TLR2 NOUN O
( PUNCT O
1 NUM O
μg NOUN O
/ ADP O
ml NOUN O
) PUNCT O
, PUNCT O
TAPI PROPN O
( PUNCT O
10 NUM O
μg NOUN O
/ ADP O
ml NOUN O
) PUNCT O
, PUNCT O
Bay PROPN O
( PUNCT O
100 NUM O
μM NOUN O
) PUNCT O
, PUNCT O
PD98059 NOUN O
( PUNCT O
20 NUM O
μM NOUN O
) PUNCT O
, PUNCT O
or CCONJ O
SB203580 NOUN O
( PUNCT O
10 NUM O
μM NOUN O
) PUNCT O
for ADP O
30 NUM O
min NOUN O
, PUNCT O
and CCONJ O
stimulated VERB O
for ADP O
2 NUM O
h NOUN O
with ADP O
eRNA NOUN B-AC
( PUNCT O
10 NUM O
μg NOUN O
/ ADP O
ml)/Pam2CSK4 NOUN O
( PUNCT O
Pam PROPN B-AC
, PUNCT O
0.1 NUM O
ng NOUN O
/ ADP O
ml NOUN O
) PUNCT O
, PUNCT O
which PRON O
were AUX O
preincubated VERB O
for ADP O
1 NUM O
h NOUN O
at ADP O
37 NUM O
° NOUN O
C NOUN O
. PUNCT O

CR PROPN B-AC
: PUNCT O
Crown NOUN B-LF
root NOUN I-LF
, PUNCT O
CK PROPN B-AC
: PUNCT O
Cytokinin PROPN B-LF
, PUNCT O
GA PROPN B-AC
: PUNCT O
Gibberellin NOUN B-LF
, PUNCT O
IAA PROPN B-AC
: PUNCT O
Auxin PROPN B-LF
, PUNCT O
QC PROPN O
: PUNCT O
Quiescent NOUN O
center NOUN O
. PUNCT O

The DET O
overlapped ADJ O
pathways NOUN O
derived VERB O
from ADP O
the DET O
Kyoto PROPN B-LF
Encyclopedia PROPN I-LF
of ADP I-LF
Genes PROPN I-LF
and CCONJ I-LF
Genomes PROPN I-LF
( PUNCT O
KEGG PROPN B-AC
) PUNCT O
and CCONJ O
Reactome PROPN O
databases NOUN O
, PUNCT O
comprising VERB O
TGFβ NOUN B-AC
signaling NOUN O
, PUNCT O
Hippo PROPN O
signaling NOUN O
, PUNCT O
and CCONJ O
phosphatidylinositol NOUN B-LF
3 NUM I-LF
kinase NOUN I-LF
( PUNCT O
PI3K)/v PROPN B-LF
- PUNCT I-LF
akt NOUN I-LF
murine NOUN I-LF
thymoma NOUN I-LF
viral ADJ I-LF
oncogene NOUN I-LF
homolog NOUN I-LF
1 NUM I-LF
( PUNCT O
Akt PROPN B-AC
) PUNCT O
signaling NOUN O
( PUNCT O
Fig PROPN O
2C NUM O
) PUNCT O
. PUNCT O
Next ADV O
, PUNCT O
we PRON O
explored VERB O
the DET O
role NOUN O
of ADP O
TGFβ NOUN B-AC
/ SYM O
Smad NOUN O
signaling NOUN O
in ADP O
P. PROPN O
gingivalis PROPN O
- PUNCT O
induced VERB O
aggressiveness NOUN O
of ADP O
ESCC PROPN B-AC
. PUNCT O
Total ADJ O
and CCONJ O
active ADJ O
TGFβ1 PROPN O
secreted VERB O
by ADP O
P. PROPN O
gingivalis PROPN O
- PUNCT O
treated VERB O
NE6 PROPN O
- PUNCT O
T PROPN O
and CCONJ O
KYSE30 PROPN O
cells NOUN O
was AUX O
significantly ADV O
augmented VERB O
compared VERB O
with ADP O
untreated ADJ O
control NOUN O
cells NOUN O
( PUNCT O
Fig PROPN O
2D NUM O
) PUNCT O
. PUNCT O
Additionally ADV O
, PUNCT O
P. PROPN O
gingivalis PROPN O
increased VERB O
the DET O
activation NOUN O
of ADP O
a DET O
TGFβ NOUN B-AC
- PUNCT O
responsive ADJ O
Smad NOUN B-LF
- PUNCT I-LF
binding VERB I-LF
element NOUN I-LF
( PUNCT O
SBE PROPN B-AC
) PUNCT O
luciferase NOUN O
reporter NOUN O
in ADP O
NE6 PROPN O
- PUNCT O
T PROPN O
and CCONJ O
KYSE30 PROPN O
cells NOUN O
at ADP O
24 NUM O
h NOUN O
postinfection NOUN O
. PUNCT O

EuroFIT PROPN B-AC
, PUNCT O
European ADJ B-LF
Fans NOUN I-LF
in ADP I-LF
Training NOUN I-LF
. PUNCT O

Excess ADJ O
weight NOUN O
, PUNCT O
a DET O
risk NOUN O
factor NOUN O
for ADP O
hypertension NOUN O
, PUNCT O
diabetes NOUN O
, PUNCT O
and CCONJ O
a DET O
range NOUN O
of ADP O
other ADJ O
noncommunicable ADJ B-LF
diseases NOUN I-LF
( PUNCT O
NCDs PROPN B-AC
) PUNCT O
, PUNCT O
has VERB O
serious ADJ O
implications NOUN O
for ADP O
economic ADJ O
growth NOUN O
in ADP O
transitioning VERB O
countries NOUN O
[ PUNCT O
12 NUM O
] PUNCT O
. PUNCT O

In ADP O
addition NOUN O
, PUNCT O
Arabidopsis PROPN O
has VERB O
three NUM O
Su(z)12 NOUN B-AC
homologues NOUN O
, PUNCT O
EMBRYONIC PROPN B-LF
FLOWER PROPN I-LF
2 NUM I-LF
( PUNCT O
EMF2 PROPN B-AC
) PUNCT O
, PUNCT O
VERNALIZATION PROPN B-LF
2 NUM I-LF
( PUNCT O
VRN2 PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
FERTILIZATION PROPN B-LF
INDEPENDENT PROPN I-LF
SEED PROPN I-LF
( PUNCT O
FIS2 PROPN B-AC
) PUNCT O
; PUNCT O
one NUM O
Esc PROPN O
homologue NOUN O
, PUNCT O
FERTILIZATION PROPN B-LF
INDEPENDENT PROPN I-LF
ENDOSPERM PROPN I-LF
( PUNCT O
FIE PROPN B-AC
) PUNCT O
; PUNCT O
and CCONJ O
five NUM O
p55 NOUN B-AC
homologues NOUN O
, PUNCT O
MULTIPLE PROPN B-LF
SUPPRESSOR PROPN I-LF
OF ADP I-LF
IRA PROPN I-LF
1–5 NUM I-LF
( PUNCT O
MSI1–5 PROPN B-AC
) PUNCT O
. PUNCT O

Protein NOUN O
levels NOUN O
of ADP O
Bbs PROPN O
proteins NOUN O
and CCONJ O
synaptic ADJ O
markers NOUN O
were AUX O
estimated VERB O
by ADP O
label NOUN O
- NOUN O
free ADJ O
LC PROPN O
- NOUN O
MS PROPN O
analyses NOUN O
from ADP O
following VERB O
biochemical ADJ O
fractions NOUN O
of ADP O
the DET O
rat NOUN O
hippocampi NOUN O
: PUNCT O
cytosolic ADJ O
, PUNCT O
detergent NOUN B-LF
- NOUN I-LF
soluble ADJ I-LF
synaptosomal ADJ I-LF
preparation NOUN O
( PUNCT O
DSS PROPN B-AC
, PUNCT O
pre ADV O
- NOUN O
synapse NOUN O
enriched VERB O
) PUNCT O
, PUNCT O
and CCONJ O
postsynaptic ADJ B-LF
density NOUN I-LF
preparation NOUN O
( PUNCT O
PSD PROPN B-AC
) PUNCT O
. PUNCT O
Protein NOUN O
levels NOUN O
of ADP O
the DET O
presynaptic ADJ O
( PUNCT O
VGLU1 PROPN B-AC
, PUNCT O
SYP PROPN B-AC
) PUNCT O
and CCONJ O
postsynaptic ADJ O
( PUNCT O
NMDAR1 PROPN O
, PUNCT O
PSD95 PROPN O
) PUNCT O
protein NOUN O
markers NOUN O
are AUX O
enriched VERB O
in ADP O
DSS PROPN B-AC
and CCONJ O
PSD PROPN B-AC
preparations NOUN O
, PUNCT O
respectively ADV O
. PUNCT O
( PUNCT O
B X O
) PUNCT O
The DET O
protein NOUN O
abundances NOUN O
illustrated VERB O
in ADP O
the DET O
heat NOUN O
map NOUN O
are AUX O
obtained VERB O
from ADP O
the DET O
total ADJ O
MS1 PROPN O
peptide NOUN O
intensities NOUN O
scaled VERB O
to ADP O
the DET O
mean NOUN O
of ADP O
all DET O
the DET O
samples NOUN O
. PUNCT O

Single ADJ B-LF
- PUNCT I-LF
wavelength NOUN I-LF
anomalous ADJ I-LF
dispersion NOUN I-LF
( PUNCT O
SAD PROPN B-AC
) PUNCT O
data NOUN O
from ADP O
ethylmercury NOUN O
phosphate NOUN O
– PUNCT O
soaked VERB O
crystals NOUN O
were AUX O
collected VERB O
using VERB O
the DET O
same ADJ O
parameters NOUN O
as ADP O
native ADJ O
data NOUN O
, PUNCT O
yielding VERB O
the DET O
same ADJ O
space NOUN O
group NOUN O
with ADP O
data NOUN O
processed VERB O
to ADP O
2.3 NUM O
Å. PUNCT O

By ADP O
comparison NOUN O
of ADP O
the DET O
predicted VERB O
and CCONJ O
experimentally ADV O
determined VERB O
pIC50 NOUN O
values NOUN O
, PUNCT O
the DET O
statistical ADJ O
parameters NOUN O
R2 NOUN O
( PUNCT O
correlation NOUN O
coefficient NOUN O
) PUNCT O
, PUNCT O
SD NOUN B-AC
( PUNCT O
standard ADJ B-LF
deviation NOUN I-LF
of ADP I-LF
regression NOUN I-LF
) PUNCT O
and CCONJ O
Root PROPN O
Mean PROPN O
Square PROPN O
Deviation PROPN O
( PUNCT O
RMSD NOUN O
) PUNCT O
were AUX O
calculated VERB O
to PART O
evaluate VERB O
the DET O
overall ADJ O
significance NOUN O
of ADP O
the DET O
model NOUN O
. PUNCT O

IM PROPN B-AC
, PUNCT O
intermodulation NOUN B-LF
; PUNCT O
MSPCres PROPN B-AC
, PUNCT O
multispectral ADJ O
phase NOUN O
coherency NOUN O
( PUNCT O
response NOUN O
) PUNCT O
. PUNCT O

Gender NOUN O
- PUNCT O
linked VERB O
impact NOUN O
of ADP O
epicardial ADJ B-LF
adipose ADJ I-LF
tissue NOUN I-LF
volume NOUN I-LF
( PUNCT O
EATV PROPN B-AC
) PUNCT O
in ADP O
patients NOUN O
undergoing VERB O
coronary ADJ B-LF
artery NOUN I-LF
bypass NOUN I-LF
grafting NOUN I-LF
( PUNCT O
CABG PROPN B-AC
) PUNCT O
remains VERB O
unknown ADJ O
. PUNCT O

To PART O
reflect VERB O
ascertainment NOUN O
bias NOUN O
, PUNCT O
we PRON O
draw VERB O
markers NOUN O
from ADP O
the DET O
set NOUN O
of ADP O
SNPs NOUN B-AC
having VERB O
minor ADJ B-LF
allele NOUN I-LF
frequency NOUN I-LF
( PUNCT O
MAF NOUN B-AC
) PUNCT O
larger ADJ O
than ADP O
1 NUM O
% PUNCT O
. PUNCT O

Cardiopulmonary ADJ B-LF
exercise NOUN I-LF
test NOUN I-LF
( PUNCT O
CPET PROPN B-AC
) PUNCT O
presents VERB O
indisputable ADJ O
clinical ADJ O
applicability NOUN O
for ADP O
the DET O
diagnosis NOUN O
of ADP O
exercise NOUN O
intolerance NOUN O
and CCONJ O
its PRON O
causes NOUN O
, PUNCT O
as ADV O
well ADV O
to PART O
quantify VERB O
cardiorespiratory ADJ B-LF
fitness NOUN I-LF
( PUNCT O
CRF NOUN B-AC
) PUNCT O
[ PUNCT O
1 NUM O
, PUNCT O
2 NUM O
] PUNCT O
. PUNCT O

Among ADP O
them PRON O
, PUNCT O
the DET O
advanced ADJ O
glycation NOUN O
endproducts NOUN O
( PUNCT O
AGEs NOUN O
) PUNCT O
Nε NOUN B-LF
- PUNCT I-LF
carboxymethyllysine NOUN I-LF
( PUNCT O
CML PROPN B-AC
) PUNCT O
, PUNCT O
pyrraline NOUN B-LF
( PUNCT O
Pyr PROPN B-AC
) PUNCT O
, PUNCT O
methylglyoxal NOUN B-LF
- PUNCT I-LF
derived VERB I-LF
hydroimidazolone NOUN I-LF
1 NUM I-LF
( PUNCT O
MG PROPN B-AC
- PUNCT B-AC
H1 PROPN B-AC
) PUNCT O
and CCONJ O
Nε NOUN B-LF
- PUNCT I-LF
carboxyethyllysine NOUN I-LF
( PUNCT O
CEL PROPN B-AC
) PUNCT O
are AUX O
the DET O
quantitatively ADV O
dominating VERB O
compounds NOUN O
during ADP O
later ADJ O
reaction NOUN O
stages NOUN O
. PUNCT O

Part NOUN O
B NOUN O
participants NOUN O
were AUX O
vaccinated VERB O
with ADP O
A PROPN O
/ NOUN O
Singapore PROPN O
/ NOUN O
GP1908/2015 NUM O
H1N1 NOUN O
at ADP O
15 NUM O
, PUNCT O
10 NUM O
, PUNCT O
5 NUM O
, PUNCT O
or CCONJ O
2.5 NUM O
μg NOUN O
HA NOUN B-AC
/ NOUN O
dose NOUN O
delivered VERB O
by ADP O
HD PROPN B-AC
- PUNCT B-AC
MAPs NOUN B-AC
applied VERB O
to ADP O
the DET O
volar ADJ O
forearm NOUN B-LF
( PUNCT O
MAP PROPN B-AC
- PUNCT O
FA-15 PROPN B-AC
, PUNCT O
MAP PROPN B-AC
- PUNCT O
FA-10 PROPN B-AC
, PUNCT O
MAP PROPN B-AC
- PUNCT O
FA-5 PROPN B-AC
, PUNCT O
MAP PROPN B-AC
- PUNCT O
FA-2.5 NUM B-AC
) PUNCT O
, PUNCT O
uncoated VERB O
HD PROPN B-AC
- PUNCT B-AC
MAPs NOUN B-AC
( PUNCT O
MAP PROPN B-AC
- PUNCT O
FA-0 PROPN B-AC
) PUNCT O
, PUNCT O
A PROPN O
/ NOUN O
Singapore PROPN O
/ NOUN O
GP1908/2015 NUM O
H1N1 NOUN O
at ADP O
15 NUM O
μg NOUN O
HA NOUN B-AC
/ NOUN O
dose NOUN O
delivered VERB O
by ADP O
HD PROPN B-AC
- PUNCT B-AC
MAP PROPN B-AC
applied VERB O
to ADP O
the DET O
upper ADJ B-LF
arm NOUN I-LF
( PUNCT O
MAP PROPN B-AC
- PUNCT O
UA-15 PROPN B-AC
) PUNCT O
, PUNCT O
or CCONJ O
injected VERB O
IM PROPN B-AC
as ADP O
a DET O
component NOUN O
of ADP O
the DET O
Afluria PROPN O
quadrivalent ADJ O
vaccine NOUN O
( PUNCT O
IM PROPN B-AC
- PUNCT O
QIV-15 PROPN B-AC
) PUNCT O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
aHR NOUN B-AC
, PUNCT O
adjusted VERB B-LF
HR NOUN I-LF
; PUNCT O
ART PROPN B-AC
, PUNCT O
antiretroviral ADJ B-LF
treatment NOUN I-LF
; PUNCT O
CD4 NOUN O
, PUNCT O
CD4 NOUN O
+ NUM O
T NOUN O
- PUNCT O
lymphocyte NOUN O
count NOUN O
; PUNCT O
cells NOUN O
/ SYM O
μL NOUN O
, PUNCT O
cells NOUN O
per ADP O
microliter NOUN O
; PUNCT O
HR NOUN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT O
NA NOUN B-AC
, PUNCT O
not PART B-LF
available ADJ I-LF

We PRON O
have AUX O
previously ADV O
reported VERB O
that SCONJ O
Ace PROPN B-AC
potentiated VERB O
ATP NOUN O
stimulated VERB O
chloride NOUN O
secretion NOUN O
in ADP O
T84 NOUN O
cells NOUN O
via ADP O
stimulation NOUN O
of ADP O
calcium NOUN B-LF
- PUNCT I-LF
activated VERB I-LF
chloride NOUN I-LF
channel NOUN I-LF
( PUNCT O
CaCC PROPN B-AC
) PUNCT O
[ PUNCT O
7 NUM O
] PUNCT O
. PUNCT O

These DET O
activities NOUN O
were AUX O
recorded VERB O
both CCONJ O
in ADP O
the DET O
extensor NOUN B-LF
carpi NOUN I-LF
radialis NOUN I-LF
( PUNCT O
ECR NOUN B-AC
) PUNCT O
and CCONJ O
flexor NOUN B-LF
carpi NOUN I-LF
radialis NOUN I-LF
( PUNCT O
FCR NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
did AUX O
not PART O
seem VERB O
to PART O
have VERB O
any DET O
relationship NOUN O
with ADP O
the DET O
illusions NOUN O
. PUNCT O

Pi NOUN B-AC
, PUNCT O
phosphate NOUN B-LF
. PUNCT O

MITI PROPN B-AC
= PUNCT O
Motivational ADJ B-LF
Interviewing NOUN I-LF
Treatment PROPN I-LF
Integrity PROPN I-LF
Code PROPN I-LF

Following VERB O
the DET O
ideas NOUN O
of ADP O
Fosang PROPN O
et PROPN O
al NOUN O
. PUNCT O
and CCONJ O
Dallmeijer PROPN O
et PROPN O
al NOUN O
. PUNCT O
, PUNCT O
who PRON O
used VERB O
a DET O
similar ADJ O
approach NOUN O
in ADP O
individuals NOUN O
with ADP O
cerebral ADJ O
palsy NOUN O
, PUNCT O
we PRON O
wanted VERB O
to PART O
compare VERB O
the DET O
maximum ADJ B-LF
isometric ADJ I-LF
joint ADJ I-LF
moments NOUN I-LF
( PUNCT O
MIM PROPN B-AC
) PUNCT O
of ADP O
people NOUN O
with ADP O
TFA PROPN B-AC
with ADP O
the DET O
corresponding ADJ O
joint ADJ O
moments NOUN O
during ADP O
walking VERB O
as SCONJ O
determined VERB O
by ADP O
conventional ADJ B-LF
clinical ADJ I-LF
gait NOUN I-LF
analysis NOUN I-LF
( PUNCT O
CGA PROPN B-AC
) PUNCT O
[ PUNCT O
27–29 NUM O
] PUNCT O
. PUNCT O

In ADP O
healthy ADJ O
pancreatic ADJ O
β NOUN O
- PUNCT O
cells NOUN O
insulin NOUN O
is AUX O
secreted VERB O
when SCONJ O
elevated VERB O
glucose NOUN O
availability NOUN O
increases VERB O
mitochondrial ADJ O
energy NOUN O
metabolism NOUN O
, PUNCT O
hyperpolarizing VERB O
the DET O
mitochondrial ADJ B-LF
membrane NOUN I-LF
potential NOUN I-LF
( PUNCT O
ΔψM NOUN B-AC
) PUNCT O
, PUNCT O
raising VERB O
the DET O
cytoplasmic ADJ O
ATP NOUN O
/ SYM O
ADP NOUN O
ratio NOUN O
, PUNCT O
closing VERB O
ATP NOUN B-LF
- PUNCT I-LF
sensitive ADJ I-LF
K+-channels NOUN I-LF
( PUNCT O
KATP NOUN B-AC
) PUNCT O
, PUNCT O
depolarizing VERB O
the DET O
plasma NOUN B-LF
membrane NOUN I-LF
potential NOUN I-LF
( PUNCT O
ΔψP NOUN B-AC
) PUNCT O
, PUNCT O
activating VERB O
Ca2 NOUN O
+ NOUN O
entry NOUN O
and CCONJ O
triggering VERB O
exocytosis NOUN O
. PUNCT O

FHS PROPN B-AC
, PUNCT O
Family PROPN B-LF
Health PROPN I-LF
Strategy PROPN I-LF
; PUNCT O
HR PROPN O
, PUNCT O
hazard NOUN O
ratio NOUN O
; PUNCT O
IPTW PROPN O
, PUNCT O
inverse ADJ O
probability NOUN O
treatment NOUN O
weighting NOUN O
. PUNCT O

BMI NOUN B-AC
: PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
, PUNCT O
CRP NOUN B-AC
: PUNCT O
C NOUN B-LF
- PUNCT I-LF
reactive ADJ I-LF
protein NOUN I-LF

CC PROPN B-LF
chemokine NOUN I-LF
receptor NOUN I-LF
type NOUN I-LF
2 NUM I-LF
( PUNCT O
CCR2 PROPN B-AC
) PUNCT O
mediates VERB O
muscle NOUN O
recruitment NOUN O
of ADP O
monocytes NOUN B-LF
/ SYM O
macrophages NOUN B-LF
( PUNCT O
MOs NOUN B-AC
/ SYM O
MPs NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
the DET O
CCR2 PROPN B-AC
- PUNCT O
mediated VERB O
inflammation NOUN O
is AUX O
essential ADJ O
to ADP O
the DET O
acute ADJ O
skeletal ADJ O
muscle NOUN O
injury NOUN O
repair NOUN O
[ PUNCT O
24 NUM O
, PUNCT O
55–61 NUM O
] PUNCT O
. PUNCT O

The DET O
inflorescence NOUN B-LF
type NOUN I-LF
( PUNCT O
IT NOUN B-AC
) PUNCT O
was AUX O
uniparous ADJ O
in ADP O
51 NUM O
( PUNCT O
41.4 NUM O
% PUNCT O
) PUNCT O
genotypes NOUN O
, PUNCT O
biparous ADJ O
in ADP O
52 NUM O
( PUNCT O
42.3 NUM O
% PUNCT O
) PUNCT O
and CCONJ O
multiparous ADJ O
in ADP O
20 NUM O
( PUNCT O
16.3 NUM O
% PUNCT O
) PUNCT O
. PUNCT O

EEG NOUN B-AC
, PUNCT O
electroencephalography NOUN B-LF
. PUNCT O

Then ADV O
the DET O
therapeutic ADJ O
effects NOUN O
of ADP O
SP PROPN B-AC
- NOUN B-AC
GNP PROPN B-AC
and CCONJ O
pure ADJ O
SP PROPN B-AC
solution NOUN O
on ADP O
6 NUM B-AC
- NOUN B-AC
OHDA PROPN B-AC
induced VERB O
hemiparkinsonian ADJ O
rats NOUN O
were AUX O
assessed VERB O
by ADP O
quantifying VERB O
rotational ADJ O
behavior NOUN O
and CCONJ O
the DET O
levels NOUN O
of ADP O
tyrosine NOUN B-LF
hydroxylase NOUN I-LF
( PUNCT O
TH NOUN B-AC
) PUNCT O
, PUNCT O
phosphorylated VERB B-LF
c NOUN I-LF
- NOUN I-LF
Jun PROPN I-LF
protein NOUN I-LF
( PUNCT O
p NOUN B-AC
- NOUN B-AC
c NOUN B-AC
- NOUN B-AC
Jun PROPN B-AC
) PUNCT O
and CCONJ O
Caspase-3 NOUN B-LF
( PUNCT O
Cas-3 NOUN B-AC
) PUNCT O
expressed VERB O
in ADP O
substantia X B-LF
nigra NOUN I-LF
( PUNCT O
SN PROPN B-AC
) PUNCT O
region NOUN O
. PUNCT O

( PUNCT O
a X O
) PUNCT O
Sustained ADJ O
exposure NOUN O
to ADP O
AA PROPN B-AC
is AUX O
harmful ADJ O
for ADP O
proximal ADJ B-LF
tubular ADJ I-LF
epithelial ADJ I-LF
cells NOUN I-LF
( PUNCT O
PTEC PROPN B-AC
) PUNCT O
leading VERB O
to ADP O
incomplete ADJ O
proliferation NOUN O
of ADP O
PTEC PROPN B-AC
resulting VERB O
in ADP O
apoptosis NOUN O
inhibition NOUN O
. PUNCT O

DF PROPN O
, PUNCT O
degrees NOUN O
of ADP O
freedom NOUN O
; PUNCT O
FREQ PROPN O
, PUNCT O
amplitude NOUN O
frequency NOUN O
; PUNCT O
MTL PROPN B-AC
, PUNCT O
medial ADJ B-LF
temporal ADJ I-LF
lobe NOUN I-LF
; PUNCT O
OFC PROPN B-AC
, PUNCT O
orbitofrontal ADJ B-LF
cortex NOUN I-LF
; PUNCT O
PAC PROPN B-AC
, PUNCT O
phase NOUN B-LF
- PUNCT I-LF
amplitude NOUN I-LF
coupling NOUN I-LF
. PUNCT O

CV NOUN B-AC
= PUNCT O
Cardiovascular ADJ B-LF

( PUNCT O
A NOUN O
, PUNCT O
B NOUN O
) PUNCT O
Nociceptive ADJ O
hypersensitivity NOUN O
in ADP O
the DET O
intraplantar ADJ O
formalin NOUN O
test NOUN O
( PUNCT O
phase NOUN O
II NUM O
) PUNCT O
is AUX O
significantly ADV O
reduced VERB O
upon SCONJ O
intrathecal ADJ O
delivery NOUN O
of ADP O
an DET O
IP3R PROPN O
blocker NOUN O
( PUNCT O
2 NUM O
- PUNCT O
APB PROPN O
) PUNCT O
or CCONJ O
an DET O
inhibitor NOUN O
of ADP O
MLC PROPN B-AC
phosphorylation NOUN O
( PUNCT O
ML-7 PROPN O
) PUNCT O
in ADP O
wild ADJ O
- PUNCT O
type NOUN O
mice NOUN O
( PUNCT O
A NOUN O
) PUNCT O
. PUNCT O
SNS PROPN O
- PUNCT O
PKG PROPN B-AC
- PUNCT B-AC
I−/− NOUN O
mice NOUN O
show VERB O
significantly ADV O
reduced VERB O
formalin NOUN O
responses NOUN O
than ADP O
PKG PROPN O
- PUNCT O
Ifl PROPN O
/ SYM O
fl PROPN O
littermates NOUN O
( PUNCT O
B NOUN O
) PUNCT O
. PUNCT O
( PUNCT O
C X O
) PUNCT O
Comparison NOUN O
of ADP O
response NOUN O
frequency NOUN O
to ADP O
von PROPN O
Frey PROPN O
hairs NOUN O
in ADP O
SNS PROPN O
- PUNCT O
PKG PROPN B-AC
- PUNCT B-AC
I−/− NOUN O
mice NOUN O
( PUNCT O
n NOUN O
= SYM O
10 NUM O
; PUNCT O
red ADJ O
squares NOUN O
) PUNCT O
and CCONJ O
PKG PROPN O
- PUNCT O
Ifl PROPN O
/ SYM O
fl PROPN O
mice NOUN O
( PUNCT O
n NOUN O
= SYM O
10 NUM O
; PUNCT O
black ADJ O
squares NOUN O
) PUNCT O
prior ADV O
to ADP O
and CCONJ O
at ADP O
12 NUM O
h NOUN O
and CCONJ O
24 NUM O
h NOUN O
following VERB O
unilateral ADJ O
hindpaw NOUN O
inflammation NOUN O
caused VERB O
by ADP O
intraplantar ADJ O
injection NOUN O
of ADP O
Complete PROPN B-LF
Freund PROPN I-LF
's PART I-LF
adjuvant NOUN I-LF
( PUNCT O
CFA PROPN B-AC
) PUNCT O
. PUNCT O
Note VERB O
that SCONJ O
leftward ADJ O
deviations NOUN O
in ADP O
stimulus NOUN O
- PUNCT O
response NOUN O
curves NOUN O
in ADP O
the DET O
inflamed VERB O
state NOUN O
over ADP O
the DET O
basal ADJ O
state NOUN O
are AUX O
much ADV O
less ADV O
pronounced ADJ O
in ADP O
SNS PROPN O
- PUNCT O
PKG PROPN B-AC
- PUNCT B-AC
I−/− NOUN O
mice NOUN O
as SCONJ O
compared VERB O
with ADP O
their PRON O
control NOUN O
PKG PROPN O
- PUNCT O
Ifl PROPN O
/ SYM O
fl PROPN O
littermates NOUN O
. PUNCT O
( PUNCT O
D NOUN O
, PUNCT O
E NOUN O
) PUNCT O
Magnitude NOUN O
and CCONJ O
time NOUN O
- PUNCT O
course NOUN O
of ADP O
mechanical ADJ O
hypersensitivity NOUN O
to ADP O
plantar ADJ O
von PROPN O
Frey PROPN O
hair NOUN O
application NOUN O
( PUNCT O
panel NOUN O
D NOUN O
) PUNCT O
and CCONJ O
thermal ADJ O
hyperalgesia NOUN O
to ADP O
radiant ADJ O
heat NOUN O
( PUNCT O
panel NOUN O
E NOUN O
) PUNCT O
following VERB O
unilateral ADJ O
hindpaw NOUN O
inflammation NOUN O
caused VERB O
by ADP O
intraplantar ADJ O
injection NOUN O
of ADP O
Complete PROPN B-LF
Freund PROPN I-LF
's PART I-LF
adjuvant NOUN I-LF
( PUNCT O
CFA PROPN B-AC
) PUNCT O
to ADP O
SNS PROPN O
- PUNCT O
PKG PROPN B-AC
- PUNCT B-AC
I−/− NOUN O
and CCONJ O
PKG PROPN O
- PUNCT O
Ifl PROPN O
/ SYM O
fl PROPN O
mice NOUN O
are AUX O
shown VERB O
. PUNCT O
* PUNCT O
p<0.05 NUM O
as SCONJ O
compared VERB O
to ADP O
PKG PROPN O
- PUNCT O
Ifl PROPN O
/ SYM O
fl PROPN O
mice NOUN O
, PUNCT O
† PUNCT O
p<0.05 NUM O
in ADP O
PKG PROPN O
- PUNCT O
Ifl PROPN O
/ SYM O
fl PROPN O
mice NOUN O
or CCONJ O
in ADP O
SNS PROPN O
- PUNCT O
PKG PROPN B-AC
- PUNCT B-AC
I−/− NOUN O
mice NOUN O
as SCONJ O
compared VERB O
to ADP O
their PRON O
own ADJ O
basal ADJ O
values NOUN O
, PUNCT O
and CCONJ O
ANOVA NOUN O
of ADP O
random ADJ O
measures NOUN O
followed VERB O
by ADP O
post X O
hoc X O
Fisher PROPN O
's PART O
test NOUN O
. PUNCT O
( PUNCT O
F NOUN O
) PUNCT O
Analysis NOUN O
of ADP O
excitability NOUN O
of ADP O
peripheral ADJ O
nociceptors NOUN O
in ADP O
PKG PROPN O
- PUNCT O
Ifl PROPN O
/ SYM O
fl PROPN O
mice NOUN O
and CCONJ O
SNS PROPN O
- PUNCT O
PKG PROPN B-AC
- PUNCT B-AC
I−/− NOUN O
mice NOUN O
. PUNCT O

HHT PROPN B-AC
= PUNCT O
Hereditary ADJ B-LF
Hemorrhagic PROPN I-LF
Telangiectasia PROPN I-LF

Table NOUN O
2 NUM O
and CCONJ O
3 NUM O
: PUNCT O
CaCx NOUN B-AC
should AUX O
read VERB O
: PUNCT O
cervical ADJ B-LF
cancer NOUN I-LF

CDA PROPN B-AC
, PUNCT O
complete ADJ B-LF
diagnostic ADJ I-LF
autopsy NOUN I-LF
; PUNCT O
MIA PROPN B-AC
, PUNCT O
minimally ADV B-LF
invasive ADJ I-LF
autopsy NOUN I-LF
. PUNCT O

Clinical ADJ O
information NOUN O
was AUX O
provided VERB O
by ADP O
the DET O
Asan PROPN B-LF
BiomedicaL PROPN I-LF
Research PROPN I-LF
Environment PROPN I-LF
( PUNCT O
ABLE PROPN B-AC
) PUNCT O
system NOUN O
. PUNCT O

We PRON O
addressed VERB O
the DET O
issue NOUN O
in ADP O
an DET O
individual ADJ O
- NOUN O
participant ADJ O
meta NOUN O
- NOUN O
analysis NOUN O
of ADP O
5,008 NUM O
people NOUN O
not PART O
being AUX O
treated VERB O
for ADP O
hypertension NOUN O
randomly ADV O
recruited VERB O
from ADP O
five NUM O
populations NOUN O
and CCONJ O
enrolled VERB O
in ADP O
the DET O
International PROPN B-LF
Database PROPN I-LF
of ADP I-LF
Home PROPN I-LF
Blood PROPN I-LF
Pressure PROPN I-LF
in ADP I-LF
Relation PROPN I-LF
to ADP I-LF
Cardiovascular PROPN I-LF
Outcome PROPN I-LF
( PUNCT O
IDHOCO PROPN B-AC
) PUNCT O
[ PUNCT O
8],[9 NUM O
] PUNCT O
. PUNCT O

In ADP O
this DET O
study NOUN O
, PUNCT O
we PRON O
utilized VERB O
our PRON O
automated VERB O
algorithm NOUN O
to PART O
examine VERB O
the DET O
relationship NOUN O
between ADP O
vessel NOUN O
density NOUN O
, PUNCT O
estimated VERB O
via ADP O
automated VERB O
analysis NOUN O
, PUNCT O
and CCONJ O
best ADV B-LF
corrected VERB I-LF
visual ADJ I-LF
acuity NOUN I-LF
( PUNCT O
BCVA PROPN B-AC
) PUNCT O
and CCONJ O
CRT NOUN B-AC
at ADP O
the DET O
baseline NOUN O
visit NOUN O
of ADP O
patients NOUN O
enrolled VERB O
in ADP O
the DET O
RECOVERY PROPN O
trial NOUN O
[ PUNCT O
22 NUM O
] PUNCT O
. PUNCT O

This DET O
paper NOUN O
describes VERB O
the DET O
recommendations NOUN O
of ADP O
The DET O
Strengthening VERB B-LF
the DET I-LF
Reporting PROPN I-LF
of ADP I-LF
Observational PROPN I-LF
Studies PROPN I-LF
in ADP I-LF
Epidemiology PROPN I-LF
( PUNCT O
STROBE PROPN B-AC
) PUNCT O
Initiative PROPN O
on ADP O
what PRON O
should AUX O
be AUX O
included VERB O
in ADP O
an DET O
accurate ADJ O
and CCONJ O
complete ADJ O
report NOUN O
of ADP O
an DET O
observational ADJ O
study NOUN O
. PUNCT O

The DET O
identification NOUN O
of ADP O
mutations NOUN O
in ADP O
important ADJ O
coronary ADJ O
artery NOUN O
disease NOUN O
associated VERB O
genes NOUN O
has AUX O
led VERB O
to PART O
the DET O
development NOUN O
of ADP O
new ADJ O
drugs NOUN O
and CCONJ O
the DET O
approach NOUN O
of ADP O
Mendelian ADJ B-LF
randomization NOUN I-LF
( PUNCT O
MR NOUN B-AC
) PUNCT O
is AUX O
widely ADV O
used VERB O
to PART O
predict VERB O
the DET O
effect NOUN O
of ADP O
interventions NOUN O
on ADP O
biomarkers NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
, PUNCT O
to PART O
validate VERB O
drug NOUN O
targets NOUN O
and CCONJ O
to PART O
predict VERB O
the DET O
effect NOUN O
of ADP O
drug NOUN O
combinations NOUN O
[ PUNCT O
2 NUM O
] PUNCT O
. PUNCT O

Granulomatosis NOUN B-LF
with ADP I-LF
polyangiitis NOUN I-LF
( PUNCT O
GPA PROPN B-AC
) PUNCT O
is AUX O
an DET O
autoimmune ADJ O
disease NOUN O
affecting VERB O
mainly ADV O
small ADJ O
blood NOUN O
vessels NOUN O
. PUNCT O

Upon SCONJ O
ligand NOUN O
binding VERB O
, PUNCT O
the DET O
Notch PROPN B-LF
intracellular ADJ I-LF
domain NOUN I-LF
( PUNCT O
NICD PROPN B-AC
) PUNCT O
travels VERB O
to ADP O
the DET O
nucleus NOUN O
, PUNCT O
binds VERB O
to ADP O
RBPJ PROPN B-AC
( PUNCT O
recombination NOUN B-LF
signal NOUN I-LF
binding VERB I-LF
protein NOUN I-LF
for ADP I-LF
immunoglobulin NOUN I-LF
kappa NOUN I-LF
J NOUN I-LF
region NOUN I-LF
) PUNCT O
, PUNCT O
and CCONJ O
mediates VERB O
gene NOUN O
transcription NOUN O
[ PUNCT O
19 NUM O
] PUNCT O
. PUNCT O

This DET O
study NOUN O
was AUX O
conducted VERB O
to PART O
directly ADV O
inform VERB O
the DET O
deliberations NOUN O
of ADP O
the DET O
Advisory PROPN B-LF
Committee PROPN I-LF
on ADP I-LF
Immunization PROPN I-LF
Practices PROPN I-LF
( PUNCT O
ACIP PROPN B-AC
) PUNCT O
to PART O
guide VERB O
HPV PROPN B-AC
vaccination NOUN O
policy NOUN O
for ADP O
women NOUN O
and CCONJ O
men NOUN O
in ADP O
the DET O
United PROPN O
States PROPN O
. PUNCT O

Error NOUN O
bars NOUN O
represent VERB O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean NOUN I-LF
( PUNCT O
SEM PROPN B-AC
) PUNCT O
. PUNCT O
Data NOUN O
were AUX O
examined VERB O
for ADP O
normal ADJ O
distribution NOUN O
and CCONJ O
variance NOUN O
to PART O
determine VERB O
if SCONJ O
any DET O
datasets NOUN O
needed VERB O
further ADJ O
analysis NOUN O
. PUNCT O

The DET O
N NOUN O
- PUNCT O
terminal NOUN O
Gly NOUN O
and CCONJ O
the DET O
GCN4 NOUN O
sequence NOUN O
in ADP O
αTM1a1 PROPN O
- PUNCT O
14Zip PROPN O
are AUX O
shown VERB O
in ADP O
small ADJ O
letters NOUN O
. PUNCT O
2D NOUN O
, PUNCT O
two NUM O
- PUNCT O
dimensional ADJ O
; PUNCT O
HSQC PROPN B-AC
, PUNCT O
heteronuclear ADJ B-LF
single ADJ I-LF
- PUNCT I-LF
quantum ADJ I-LF
coherence NOUN I-LF
; PUNCT O
Lmod NOUN B-AC
, PUNCT O
leiomodin NOUN B-LF
. PUNCT O

NS5A PROPN O
also ADV O
attenuates VERB O
IFN PROPN B-AC
action NOUN O
by ADP O
inducing VERB O
expression NOUN O
and CCONJ O
secretion NOUN O
of ADP O
interleukin NOUN B-LF
( PUNCT O
IL)-8 NUM B-AC
, PUNCT O
a DET O
pro ADJ O
- PUNCT O
inflammatory ADJ O
chemokine NOUN O
that PRON O
interferes VERB O
with ADP O
IFN PROPN B-AC
through ADP O
alterations NOUN O
in ADP O
IFN PROPN B-LF
- PUNCT I-LF
stimulated VERB I-LF
genes NOUN I-LF
( PUNCT O
ISG PROPN B-AC
) PUNCT O
[ PUNCT O
7 NUM O
] PUNCT O
. PUNCT O

In ADP O
cystic ADJ B-LF
fibrosis NOUN I-LF
( PUNCT O
CF PROPN B-AC
) PUNCT O
, PUNCT O
lung NOUN O
damage NOUN O
is AUX O
mediated VERB O
by ADP O
a DET O
cycle NOUN O
of ADP O
obstruction NOUN O
, PUNCT O
infection NOUN O
, PUNCT O
and CCONJ O
inflammation NOUN O
. PUNCT O

Our PRON O
analysis NOUN O
of ADP O
distributive ADJ B-LF
conjugal ADJ I-LF
transfer NOUN I-LF
( PUNCT O
DCT PROPN B-AC
) PUNCT O
in ADP O
M. PROPN O
smegmatis PROPN O
has VERB O
practical ADJ O
and CCONJ O
conceptual ADJ O
ramifications NOUN O
. PUNCT O

After SCONJ O
further ADJ O
adjustments NOUN O
were AUX O
made VERB O
for ADP O
the DET O
indices NOUN O
of ADP O
waist NOUN B-LF
circumference NOUN I-LF
( PUNCT O
WC NOUN B-AC
) PUNCT O
, PUNCT O
fasting VERB B-LF
blood NOUN I-LF
glucose NOUN I-LF
( PUNCT O
FBG NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
blood NOUN O
lipids NOUN O
( PUNCT O
TG NOUN B-AC
and CCONJ O
HDL NOUN B-AC
- PUNCT B-AC
C NOUN B-AC
) PUNCT O
alone ADV O
or CCONJ O
in ADP O
combination NOUN O
, PUNCT O
the DET O
correlations NOUN O
were AUX O
slightly ADV O
attenuated VERB O
, PUNCT O
but CCONJ O
remained VERB O
statistically ADV O
significant ADJ O
( PUNCT O
all DET O
P NOUN O
trend<0.001 NUM O
) PUNCT O
. PUNCT O

Odds NOUN B-LF
ratios NOUN I-LF
( PUNCT O
OR NOUN B-AC
) PUNCT O
, PUNCT O
sensitivity NOUN O
, PUNCT O
specificity NOUN O
, PUNCT O
positive ADJ B-LF
and CCONJ I-LF
negative ADJ I-LF
predictive ADJ I-LF
values NOUN I-LF
( PUNCT O
PPV NOUN B-AC
and CCONJ B-AC
NPV PROPN B-AC
) PUNCT O
, PUNCT O
positive ADJ O
and CCONJ O
negative ADJ O
likelihood NOUN O
ratios NOUN O
, PUNCT O
and CCONJ O
area NOUN O
under ADP O
the DET O
receiver NOUN B-LF
operator NOUN I-LF
characteristic ADJ I-LF
( PUNCT O
AUROC PROPN B-AC
) PUNCT O
curve NOUN O
are AUX O
reported VERB O
. PUNCT O

AFASS PROPN B-AC
— PUNCT O
affordable ADJ O
, PUNCT O
feasible ADJ O
, PUNCT O
acceptable ADJ O
sustainable ADJ O
and CCONJ O
safe ADJ O
, PUNCT O
ART- PROPN B-AC
antiretroviral ADJ B-LF
therapy NOUN I-LF
, PUNCT O
HAART PROPN B-AC
— PUNCT O
highly ADV B-LF
active ADJ I-LF
antiretroviral ADJ I-LF
treatment NOUN I-LF
, PUNCT O
NVP PROPN B-AC
— PUNCT O
Nevirapine PROPN B-LF
, PUNCT O
ZDV PROPN B-AC
— PUNCT O
Zidovudine PROPN B-LF
, PUNCT O
3TC- PROPN B-AC
Lamuvudine PROPN B-LF

Our PRON O
first ADJ O
management NOUN O
reference NOUN O
point NOUN O
for ADP O
reserve NOUN O
coverage NOUN O
policy NOUN O
decisions NOUN O
( PUNCT O
the DET O
“ PUNCT O
maximum ADJ O
biodiversity NOUN O
benefit NOUN O
without ADP O
fisheries NOUN O
costs NOUN O
” PUNCT O
) PUNCT O
was AUX O
based VERB O
on ADP O
the DET O
assumption NOUN O
that SCONJ O
even ADV O
regularly ADV O
assessed VERB O
and CCONJ O
controlled VERB O
fisheries NOUN O
in ADP O
developed VERB O
countries NOUN O
are AUX O
difficult ADJ O
to ADP O
maintain VERB O
close ADV O
to ADP O
MSY PROPN B-AC
or CCONJ O
maximum ADJ B-LF
economic ADJ I-LF
yield NOUN I-LF
( PUNCT O
MEY PROPN B-AC
) PUNCT O
[ PUNCT O
28,54 NUM O
] PUNCT O
. PUNCT O

Multivariable ADV O
- PUNCT O
adjusted VERB O
Poisson PROPN O
regression NOUN O
was AUX O
used VERB O
to PART O
identify VERB O
factors NOUN O
associated VERB O
with ADP O
hospitalization NOUN O
rates NOUN O
, PUNCT O
including VERB O
demographics NOUN O
, PUNCT O
blood NOUN O
pressure NOUN O
, PUNCT O
estimated VERB B-LF
glomerular ADJ I-LF
filtration NOUN I-LF
rate NOUN I-LF
( PUNCT O
eGFR NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
proteinuria NOUN O
. PUNCT O

ADAR1 PROPN B-AC
, PUNCT O
adenosine NOUN B-LF
deaminase NOUN I-LF
acting VERB I-LF
on ADP I-LF
RNA NOUN I-LF
1 NUM I-LF
; PUNCT O
AGS1 PROPN O
, PUNCT O
Aicardi PROPN O
- PUNCT O
Goutières PROPN O
Syndrome PROPN O
type NOUN O
1 NUM O
; PUNCT O
AGS2 PROPN O
, PUNCT O
Aicardi PROPN O
- PUNCT O
Goutières PROPN O
Syndrome PROPN O
type NOUN O
2 NUM O
; PUNCT O
AGS4 PROPN O
, PUNCT O
Aicardi PROPN O
- PUNCT O
Goutières PROPN O
Syndrome PROPN O
type NOUN O
4 NUM O
; PUNCT O
AGS5 PROPN O
, PUNCT O
Aicardi PROPN O
- PUNCT O
Goutières PROPN O
Syndrome PROPN O
type NOUN O
5 NUM O
; PUNCT O
RNAseq PROPN B-AC
, PUNCT O
RNA NOUN B-LF
sequencing NOUN I-LF
; PUNCT O
UTR PROPN B-AC
, PUNCT O
untranslated ADJ B-LF
region NOUN I-LF
; PUNCT O
VOPP1 PROPN B-AC
, PUNCT O
vesicular ADJ B-LF
, PUNCT I-LF
overexpressed VERB I-LF
in ADP I-LF
cancer NOUN I-LF
, PUNCT I-LF
prosurvival ADJ I-LF
protein NOUN I-LF
1 NUM I-LF
. PUNCT O

Psychological ADJ O
interventions NOUN O
were AUX O
defined VERB O
as ADP O
interventions NOUN O
incorporating VERB O
a DET O
structured ADJ O
and CCONJ O
explicitly ADV O
psychological ADJ O
approach NOUN O
, PUNCT O
such ADJ O
as ADP O
cognitive ADJ B-LF
behavior NOUN I-LF
therapy NOUN I-LF
( PUNCT O
CBT PROPN B-AC
) PUNCT O
or CCONJ O
interpersonal ADJ B-LF
therapy NOUN I-LF
( PUNCT O
IPT PROPN B-AC
) PUNCT O
. PUNCT O

Principal ADJ B-LF
component NOUN I-LF
analysis NOUN I-LF
( PUNCT O
PCA PROPN B-AC
) PUNCT O
clustering NOUN O
and CCONJ O
variance NOUN O
explained VERB O
. PUNCT O

LD NOUN B-AC
, PUNCT O
long ADJ B-LF
- PUNCT I-LF
day NOUN I-LF
; PUNCT O
SD PROPN B-AC
, PUNCT O
short ADJ B-LF
- PUNCT I-LF
day NOUN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

The DET O
authors NOUN O
used VERB O
two NUM O
sets NOUN O
of ADP O
lipidomics NOUN O
data NOUN O
( PUNCT O
" PUNCT O
1061 NUM O
participants NOUN O
of ADP O
the DET O
FINRISK PROPN O
2012 NUM O
population NOUN O
cohort NOUN O
" PUNCT O
and CCONJ O
" PUNCT O
250 NUM O
randomly ADV O
chosen VERB O
participants NOUN O
of ADP O
the DET O
Malmö PROPN O
Diet PROPN O
and CCONJ O
Cancer PROPN O
Cardiovascular PROPN O
Cohort PROPN O
" PUNCT O
) PUNCT O
to PART O
build VERB O
and CCONJ O
test VERB O
the DET O
regression NOUN O
model NOUN O
for ADP O
predicting VERB O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT O
BMI PROPN B-AC
) PUNCT O
, PUNCT O
waist NOUN B-LF
circumference NOUN I-LF
( PUNCT O
WC PROPN B-AC
) PUNCT O
, PUNCT O
waist NOUN B-LF
- PUNCT I-LF
hip NOUN I-LF
ratio NOUN I-LF
( PUNCT O
WHR NOUN B-AC
) PUNCT O
and CCONJ O
body NOUN B-LF
fat NOUN I-LF
percentage NOUN I-LF
( PUNCT O
BFP PROPN B-AC
) PUNCT O
with ADP O
consideration NOUN O
of ADP O
gender NOUN O
and CCONJ O
age NOUN O
. PUNCT O

The DET O
main ADJ O
mRNA NOUN B-LF
decapping NOUN I-LF
2 NUM I-LF
( PUNCT O
Dcp2 NOUN B-AC
) PUNCT O
mediates VERB O
the DET O
decapping NOUN O
of ADP O
almost ADV O
all PRON O
major ADJ O
ATG NOUN O
mRNAs NOUN O
, PUNCT O
whereas SCONJ O
the DET O
RNA NOUN O
exoribonuclease NOUN B-LF
1 NUM I-LF
( PUNCT O
Xrn1 NOUN B-AC
) PUNCT O
is AUX O
responsible ADJ O
for ADP O
the DET O
degradation NOUN O
of ADP O
some PRON O
of ADP O
them PRON O
. PUNCT O

LAA% NOUN B-AC
: PUNCT O
percentage NOUN O
of ADP O
lung NOUN O
field NOUN O
occupied VERB O
by ADP O
low ADJ B-LF
attenuation NOUN I-LF
areas NOUN I-LF
; PUNCT O
LAA_n NOUN B-AC
: PUNCT O
number NOUN B-LF
of ADP I-LF
LAA PROPN I-LF
cluster NOUN I-LF
. PUNCT O

Furthermore ADV O
, PUNCT O
no DET O
modification NOUN O
of ADP O
morphology NOUN O
was AUX O
observed VERB O
with ADP O
the DET O
wild ADJ B-LF
- NOUN I-LF
type NOUN I-LF
α NOUN B-AC
- NOUN B-AC
syn NOUN B-AC
protein NOUN O
( PUNCT O
WT PROPN B-AC
) PUNCT O
and CCONJ O
the DET O
E46 PROPN O
K PROPN O
mutant NOUN O
. PUNCT O

SA PROPN O
, PUNCT O
sphinganine NOUN O
; PUNCT O
SO NOUN O
, PUNCT O
sphingosine NOUN O
; PUNCT O
TG NOUN B-AC
, PUNCT O
triglycerides NOUN B-LF

By ADP O
harnessing VERB O
specific ADJ O
chemical ADJ O
signatures NOUN O
, PUNCT O
Magnetic PROPN B-LF
Resonance PROPN I-LF
Spectroscopy PROPN I-LF
( PUNCT O
MRS PROPN B-AC
) PUNCT O
techniques NOUN O
detecting VERB O
weak ADJ O
but CCONJ O
cell NOUN O
- ADJ O
specific ADJ O
metabolic ADJ O
signals NOUN O
could AUX O
open VERB O
a DET O
unique ADJ O
window NOUN O
to ADP O
performing VERB O
similar ADJ O
observations NOUN O
in ADP O
a DET O
non ADJ O
- ADJ O
invasive ADJ O
, PUNCT O
in ADP O
vivo ADJ O
fashion NOUN O
[ X O
7–11 NUM O
] PUNCT O
. PUNCT O

SD NOUN B-AC
: PUNCT O
standard ADJ B-LF
deviation NOUN I-LF
. PUNCT O

AKI PROPN B-AC
, PUNCT O
acute ADJ B-LF
kidney NOUN I-LF
injury NOUN I-LF
; PUNCT O
ALI PROPN B-AC
, PUNCT O
acute ADJ B-LF
lung NOUN I-LF
injury NOUN I-LF
; PUNCT O
DIC PROPN B-AC
, PUNCT O
disseminated VERB B-LF
intravascular ADJ I-LF
coagulation NOUN I-LF
; PUNCT O
LOS PROPN B-AC
, PUNCT O
length NOUN B-LF
of ADP I-LF
stay NOUN I-LF
; PUNCT O
MODS PROPN B-AC
, PUNCT O
multi ADJ B-LF
- ADJ I-LF
organ ADJ I-LF
dysfunction NOUN I-LF
syndrome NOUN I-LF
; PUNCT O
MV PROPN B-AC
, PUNCT O
mechanical ADJ B-LF
ventilation NOUN I-LF
; PUNCT O
PICU PROPN B-AC
, PUNCT O
pediatric ADJ B-LF
intensive ADJ I-LF
care NOUN I-LF
unit NOUN I-LF
; PUNCT O
RRT PROPN B-AC
, PUNCT O
renal ADJ B-LF
replacement NOUN I-LF
therapy NOUN I-LF
. PUNCT O

In ADP O
order NOUN O
to ADP O
fate NOUN O
map VERB O
candidate NOUN O
neural ADJ O
stem NOUN O
cells NOUN O
close ADJ O
to ADP O
the DET O
central ADJ O
canal NOUN O
, PUNCT O
we PRON O
generated VERB O
two NUM O
transgenic ADJ O
mouse NOUN O
lines NOUN O
expressing VERB O
tamoxifen NOUN B-LF
- PUNCT I-LF
dependent ADJ I-LF
Cre PROPN I-LF
recombinase NOUN I-LF
( PUNCT O
CreER PROPN B-AC
) PUNCT O
under ADP O
the DET O
control NOUN O
of ADP O
FoxJ1 PROPN O
( PUNCT O
HFH4 PROPN O
) PUNCT O
or CCONJ O
Nestin PROPN O
regulatory ADJ O
sequences NOUN O
. PUNCT O

Abbreviation NOUN O
: PUNCT O
OR PROPN B-AC
, PUNCT O
odds NOUN B-LF
ratio NOUN I-LF
; PUNCT O
CI NOUN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
. PUNCT O

A DET O
set NOUN O
of ADP O
400 NUM O
test NOUN O
peptides NOUN O
of ADP O
the DET O
general ADJ O
form NOUN O
X PROPN O
- PUNCT O
Z PROPN O
- PUNCT O
Gly PROPN O
- PUNCT O
Pro PROPN O
were AUX O
docked VERB O
to ADP O
a DET O
subset NOUN O
of ADP O
cyclophilin NOUN O
isoforms NOUN O
( PUNCT O
Protein PROPN B-LF
Data PROPN I-LF
Bank PROPN I-LF
[ X O
PDB PROPN B-AC
] PUNCT O
codes NOUN O
: PUNCT O
PPIA PROPN O
, PUNCT O
1AK4 PROPN O
: PUNCT O
PPIL2 PROPN O
, PUNCT O
1ZKC PROPN O
; PUNCT O
PPIC PROPN O
, PUNCT O
2ESL PROPN O
; PUNCT O
PPWD1 PROPN O
, PUNCT O
2A2N PROPN O
; PUNCT O
and CCONJ O
NKTR PROPN O
, PUNCT O
2HE9 NUM O
) PUNCT O
using VERB O
ICM PROPN O
software NOUN O
( PUNCT O
Molsoft PROPN O
LLC PROPN O
) PUNCT O
. PUNCT O
Monte PROPN O
Carlo PROPN O
simulations NOUN O
were AUX O
performed VERB O
to ADP O
sample VERB O
conformational ADJ O
space NOUN O
for ADP O
each DET O
combination NOUN O
of ADP O
cyclophilin NOUN O
isoform NOUN O
and CCONJ O
test NOUN O
peptide NOUN O
, PUNCT O
allowing VERB O
flexibility NOUN O
of ADP O
the DET O
tetrapeptide NOUN O
and CCONJ O
the DET O
sidechains NOUN O
of ADP O
the DET O
gatekeepers NOUN O
at ADP O
positions NOUN O
comparable ADJ O
to ADP O
PPIA PROPN O
Thr73 PROPN O
, PUNCT O
Lys82 PROPN O
, PUNCT O
and CCONJ O
Ala103 PROPN O
, PUNCT O
and CCONJ O
keeping VERB O
the DET O
rest NOUN O
of ADP O
the DET O
protein NOUN O
receptor NOUN O
rigid ADJ O
[ X O
64 NUM O
] PUNCT O
. PUNCT O

From ADP O
these DET O
subgroup NOUN O
analyses NOUN O
only ADV O
the DET O
odds NOUN B-LF
ratio NOUN I-LF
( PUNCT O
OR NOUN B-AC
) PUNCT O
of ADP O
the DET O
HEMS NOUN B-AC
( PUNCT O
relative ADJ O
to ADP O
GEMS PROPN B-AC
) PUNCT O
was AUX O
reported VERB O
, PUNCT O
with ADP O
95 NUM O
% NOUN O
CI NOUN B-AC
. PUNCT O

cBMI NOUN B-AC
, PUNCT O
corrected VERB B-LF
body NOUN I-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
DBP PROPN B-AC
, PUNCT O
diastolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
; PUNCT O
ECW PROPN B-AC
, PUNCT O
extracellular ADJ B-LF
water NOUN I-LF
; PUNCT O
eGFR NOUN B-AC
, PUNCT O
estimated VERB B-LF
glomerular ADJ I-LF
filtration NOUN I-LF
rate NOUN I-LF
; PUNCT O
HbA1C PROPN B-AC
, PUNCT O
hemoglobin NOUN B-LF
A1C NOUN I-LF
; PUNCT O
HDL PROPN B-AC
- PUNCT B-AC
C PROPN B-AC
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
cholesterol NOUN I-LF
; PUNCT O
hs NOUN B-AC
- PUNCT B-AC
CRP PROPN B-AC
high ADJ O
- PUNCT O
sensitivity NOUN O
C PROPN O
reactive ADJ O
protein NOUN O
; PUNCT O
iPTH PROPN B-AC
, PUNCT O
intact ADJ B-LF
parathyroid ADJ I-LF
hormone NOUN I-LF
; PUNCT O
LAD PROPN B-AC
, PUNCT O
left ADJ B-LF
atrial ADJ I-LF
dimension NOUN I-LF
; PUNCT O
LAVI PROPN B-AC
, PUNCT O
left ADJ B-LF
atrial ADJ I-LF
volume NOUN I-LF
index NOUN I-LF
; PUNCT O
LDL PROPN B-AC
- PUNCT B-AC
C PROPN B-AC
, PUNCT O
low ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
cholesterol NOUN I-LF
; PUNCT O
LVEDD PROPN B-AC
, PUNCT O
left ADJ B-LF
ventricular ADJ I-LF
end NOUN I-LF
- PUNCT I-LF
diastolic ADJ I-LF
dimension NOUN I-LF
; PUNCT O
LVEF PROPN B-AC
, PUNCT O
left ADJ B-LF
ventricular ADJ I-LF
ejection NOUN I-LF
fraction NOUN I-LF
; PUNCT O
LVEDV PROPN B-AC
, PUNCT O
left ADJ B-LF
ventricular ADJ I-LF
end NOUN I-LF
- PUNCT I-LF
diastolic ADJ I-LF
volume NOUN I-LF
; PUNCT O
LVH PROPN B-AC
, PUNCT O
left ADJ B-LF
ventricular ADJ I-LF
hypertrophy NOUN I-LF
; PUNCT O
LVMI PROPN B-AC
, PUNCT O
left ADJ B-LF
ventricular ADJ I-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
NT NOUN B-AC
- PUNCT B-AC
proBNP PROPN B-AC
, PUNCT O
N NOUN B-LF
- PUNCT I-LF
terminal ADJ I-LF
prohormone NOUN I-LF
of ADP I-LF
B NOUN I-LF
- PUNCT I-LF
type NOUN I-LF
natriuretic ADJ I-LF
peptide NOUN I-LF
; PUNCT O
OH PROPN B-AC
, PUNCT O
overhydration NOUN B-LF
; PUNCT O
RWT PROPN B-AC
, PUNCT O
relative ADJ B-LF
wall NOUN I-LF
thickness NOUN I-LF
; PUNCT O
SBP NOUN B-AC
, PUNCT O
systolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
; PUNCT O
TBW PROPN B-AC
, PUNCT O
total ADJ B-LF
body NOUN I-LF
water NOUN I-LF
. PUNCT O

TB PROPN B-AC
: PUNCT O
tuberculosis NOUN B-LF
, PUNCT O
QFT PROPN B-AC
: PUNCT O
QuantiFERON PROPN B-LF
- PUNCT I-LF
TB PROPN I-LF
Gold PROPN I-LF
In PROPN I-LF
- PUNCT I-LF
Tube PROPN I-LF
, PUNCT O
TST NOUN B-AC
: PUNCT O
Tuberculin PROPN B-LF
Skin PROPN I-LF
Test PROPN I-LF
. PUNCT O

The DET O
following ADJ O
TaqManAssay PROPN O
- PUNCT O
on ADP O
- PUNCT O
Demand NOUN O
primer NOUN O
sets NOUN O
for ADP O
mouse NOUN O
gene NOUN O
expression NOUN O
analysis NOUN O
were AUX O
purchased VERB O
from ADP O
Invitrogen PROPN O
: PUNCT O
AnxA6 PROPN O
( PUNCT O
mAnxA6 PROPN O
, PUNCT O
Mm00478966_m1 NOUN O
) PUNCT O
, PUNCT O
carnitine NOUN B-LF
palmitoyltransferase NOUN I-LF
1A PROPN I-LF
( PUNCT O
CPT1α PROPN B-AC
; PUNCT O
mCpt1a NOUN O
liver NOUN O
, PUNCT O
Mm00550438_m1 NOUN O
) PUNCT O
, PUNCT O
fatty NOUN O
acid NOUN O
synthase NOUN O
( PUNCT O
mFasn PROPN O
, PUNCT O
Mm00662319_m1 NOUN O
) PUNCT O
, PUNCT O
fibroblast NOUN O
growth NOUN O
factor NOUN O
21 NUM O
( PUNCT O
Fgf21 PROPN O
; PUNCT O
mFgf21 PROPN O
, PUNCT O
Mm00840165_g1 NOUN O
) PUNCT O
, PUNCT O
glucose-6 NOUN O
phosphatase NOUN O
( PUNCT O
G6P PROPN B-AC
) PUNCT O
catalytic ADJ O
( PUNCT O
mG6pc PROPN O
, PUNCT O
Mm00839363_m1 NOUN O
) PUNCT O
, PUNCT O
solute NOUN O
carrier NOUN O
family NOUN O
2 NUM O
( PUNCT O
facilitated VERB O
glucose NOUN O
transporter NOUN O
) PUNCT O
, PUNCT O
member NOUN O
2 NUM O
( PUNCT O
SLC2A2 PROPN O
, PUNCT O
GLUT2 PROPN O
; PUNCT O
mSlc2a2 PROPN O
, PUNCT O
mGlut2 PROPN O
, PUNCT O
Mm00446224_m1 NOUN O
) PUNCT O
, PUNCT O
insulin NOUN O
induced VERB O
gene NOUN O
1 NUM O
( PUNCT O
Insig1 PROPN O
; PUNCT O
mInsig1 PROPN O
, PUNCT O
Mm00463389_m1 NOUN O
) PUNCT O
, PUNCT O
hydroxyacyl NOUN O
- PUNCT O
Coenzyme NOUN O
A PROPN O
dehydrogenase/3 NOUN O
- PUNCT O
ketoacyl NOUN O
- PUNCT O
Coenzyme NOUN O
A PROPN O
thiolase NOUN O
/ SYM O
enoyl NOUN O
- PUNCT O
Coenzyme NOUN O
A PROPN O
hydratase NOUN O
( PUNCT O
trifunctional ADJ O
protein NOUN O
) PUNCT O
, PUNCT O
α NOUN O
( PUNCT O
mHadha X O
, PUNCT O
Mm00805228_m1 NOUN O
) PUNCT O
and CCONJ O
β NOUN O
subunit NOUN O
( PUNCT O
mHadhb NOUN O
, PUNCT O
Mm00523880_g1 NOUN O
, PUNCT O
LDLR NOUN O
( PUNCT O
mLdlr NOUN O
, PUNCT O
Mm00440169_m1 NOUN O
) PUNCT O
, PUNCT O
pyruvate NOUN O
dehydrogenase NOUN O
lipoamide NOUN O
kinase NOUN O
isozyme NOUN O
4 NUM O
( PUNCT O
mPdk4 NOUN O
, PUNCT O
Mm00443325_m1 NOUN O
) PUNCT O
, PUNCT O
TATA PROPN O
- PUNCT O
box NOUN O
binding VERB O
protein NOUN O
( PUNCT O
Tbp NOUN O
; PUNCT O
mTbp NOUN O
( PUNCT O
Mm00446973_m1 NOUN O
) PUNCT O
. PUNCT O

To PART O
explore VERB O
the DET O
underlying VERB O
mechanism NOUN O
for ADP O
the DET O
rescue NOUN O
effect NOUN O
of ADP O
E2 PROPN B-AC
treatment NOUN O
in ADP O
response NOUN O
to ADP O
TCF7L2DN NOUN B-AC
- PUNCT O
mediated VERB O
functional ADJ O
knockdown NOUN O
; PUNCT O
we PRON O
tested VERB O
the DET O
in ADP O
vitro X O
effect NOUN O
of ADP O
E2 PROPN B-AC
in ADP O
MPH NOUN B-AC
. PUNCT O
We PRON O
found VERB O
that SCONJ O
6 NUM O
- PUNCT O
hour NOUN O
E2 PROPN B-AC
treatment NOUN O
stimulated VERB O
β NOUN B-AC
- PUNCT B-AC
cat NOUN B-AC
Ser675 NOUN O
phosphorylation NOUN O
( PUNCT O
Fig PROPN O
4A NUM O
) PUNCT O
, PUNCT O
and CCONJ O
the DET O
stimulation NOUN O
increased VERB O
along ADP O
with ADP O
the DET O
treatment NOUN O
time NOUN O
within ADP O
the DET O
120 NUM O
- PUNCT O
minute NOUN O
experimental ADJ O
time NOUN O
( PUNCT O
Fig PROPN O
4B NUM O
) PUNCT O
. PUNCT O
E2 PROPN B-AC
treatment NOUN O
also ADV O
transiently ADV O
increased VERB O
cAMP NOUN B-LF
response NOUN I-LF
element NOUN I-LF
- PUNCT I-LF
binding VERB I-LF
protein NOUN I-LF
( PUNCT O
CREB PROPN B-AC
) PUNCT O
phosphorylation NOUN O
( PUNCT O
Ser133 PROPN O
) PUNCT O
( PUNCT O
at ADP O
15 NUM O
minutes NOUN O
, PUNCT O
S6 PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

As ADP O
in ADP O
the DET O
case NOUN O
of ADP O
anterior ADJ B-LF
- PUNCT I-LF
posterior ADJ I-LF
( PUNCT O
AP PROPN B-AC
) PUNCT O
patterning NOUN O
, PUNCT O
where SCONJ O
apparently ADV O
species NOUN O
- PUNCT O
specific ADJ O
upstream ADJ O
processes NOUN O
activate VERB O
HOX NOUN O
genes NOUN O
in ADP O
a DET O
conserved VERB O
order NOUN O
along ADP O
the DET O
AP PROPN B-AC
axis NOUN O
[ PUNCT O
22 NUM O
] PUNCT O
, PUNCT O
distinct ADJ O
pathways NOUN O
have AUX O
been AUX O
implicated VERB O
in ADP O
DV PROPN B-AC
patterning NOUN O
of ADP O
the DET O
neuroectoderm NOUN O
. PUNCT O

The DET O
expression NOUN O
of ADP O
PGC-1α NOUN O
and CCONJ O
FOXO1 PROPN O
further ADV O
enhanced ADJ O
by ADP O
day NOUN O
6 NUM O
, PUNCT O
furthermore ADV O
, PUNCT O
PGC-1β NOUN O
, PUNCT O
another DET O
key ADJ O
mitotropic ADJ O
regulator NOUN O
[ X O
24–26 NUM O
] X O
boosted VERB O
upon SCONJ O
AICAR+MTX PROPN B-AC
treatment NOUN O
( PUNCT O
Fig PROPN O
3C NUM O
) PUNCT O
. PUNCT O
Consequently ADV O
, PUNCT O
on ADP O
day NOUN O
6 NUM O
enhanced ADJ O
expression NOUN O
of ADP O
ATP5g1 NOUN O
and CCONJ O
IDH2 PROPN B-AC
in ADP O
the DET O
AICAR+MTX PROPN B-AC
treated VERB O
cells NOUN O
was AUX O
exacerbated VERB O
, PUNCT O
moreover ADV O
, PUNCT O
other ADJ O
TCA PROPN O
cycle NOUN O
enzymes NOUN O
, PUNCT O
fumarase NOUN O
and CCONJ O
aconitase-2 NOUN B-LF
( PUNCT O
ACO2 PROPN B-AC
) PUNCT O
were AUX O
also ADV O
induced VERB O
( PUNCT O
Fig PROPN O
3C NUM O
) PUNCT O
. PUNCT O

At ADP O
least ADV O
eight NUM O
genotypes NOUN O
of ADP O
Hepatitis PROPN B-LF
B PROPN I-LF
virus NOUN I-LF
( PUNCT O
HBV PROPN B-AC
) PUNCT O
have AUX O
been AUX O
identified VERB O
. PUNCT O

This DET O
subset NOUN O
includes VERB O
molecules NOUN O
such ADJ O
as ADP O
vascular ADJ B-LF
endothelial ADJ I-LF
cadherin NOUN I-LF
( PUNCT O
VE PROPN B-AC
- PUNCT B-AC
Cadherin PROPN B-AC
) PUNCT O
, PUNCT O
platelet NOUN B-LF
endothelial ADJ I-LF
cell NOUN I-LF
adhesion NOUN I-LF
molecule NOUN I-LF
( PUNCT O
PECAM-1 PROPN B-AC
) PUNCT O
( PUNCT O
cluster NOUN B-LF
of ADP I-LF
differentiation NOUN I-LF
[ X O
CD]31 X B-AC
) PUNCT O
, PUNCT O
CD99 NOUN O
, PUNCT O
endothelial ADJ B-LF
cell NOUN I-LF
- PUNCT I-LF
selective ADJ I-LF
adhesion NOUN I-LF
molecule NOUN I-LF
( PUNCT O
ESAM PROPN B-AC
) PUNCT O
, PUNCT O
intercellular ADJ O
adhesion NOUN O
molecule NOUN O
1 NUM O
and CCONJ O
2 NUM O
( PUNCT O
ICAM-1 PROPN O
and CCONJ O
-2 NUM O
) PUNCT O
, PUNCT O
and CCONJ O
the DET O
junctional ADJ O
adhesion NOUN O
molecule NOUN O
( PUNCT O
JAM PROPN O
) PUNCT O
family NOUN O
of ADP O
proteins NOUN O
( PUNCT O
JAM PROPN O
- PUNCT O
A PROPN O
, PUNCT O
B PROPN O
, PUNCT O
and CCONJ O
C PROPN O
) PUNCT O
[ X O
2,6 NUM O
] PUNCT O
. PUNCT O

Urine NOUN O
specimens NOUN O
were AUX O
submitted VERB O
for ADP O
immediate ADJ O
analysis NOUN O
of ADP O
urine NOUN O
pH NOUN O
, PUNCT O
urine NOUN B-LF
specific ADJ I-LF
gravity NOUN I-LF
( PUNCT O
USG PROPN B-AC
) PUNCT O
, PUNCT O
routine ADJ O
dipstick NOUN O
analysis NOUN O
, PUNCT O
semi ADJ O
- ADJ O
quantitative ADJ O
urine NOUN O
sediment NOUN O
analysis NOUN O
, PUNCT O
and CCONJ O
calculation NOUN O
of ADP O
urine NOUN B-LF
protein NOUN I-LF
: PUNCT I-LF
creatinine NOUN I-LF
( PUNCT O
UPC PROPN B-AC
) PUNCT O
ratio NOUN O
. PUNCT O

In ADP O
this DET O
paper NOUN O
, PUNCT O
we PRON O
develop VERB O
an DET O
individual NOUN B-LF
- PUNCT I-LF
based VERB I-LF
model NOUN I-LF
( PUNCT O
IBM PROPN B-AC
) PUNCT O
to PART O
study VERB O
potential ADJ O
mechanisms NOUN O
for ADP O
coexistence NOUN O
of ADP O
multiple ADJ O
epitope NOUN O
- PUNCT O
specific ADJ O
T PROPN O
cell NOUN O
populations NOUN O
. PUNCT O

Acta2 PROPN B-AC
, PUNCT O
smooth ADJ B-LF
muscle NOUN I-LF
actin NOUN I-LF
alpha NOUN I-LF
2 NUM I-LF
; PUNCT O
Col1ɑ1 PROPN B-AC
, PUNCT O
collagen NOUN B-LF
type NOUN I-LF
I NOUN I-LF
ɑ NOUN I-LF
1 NUM I-LF
; PUNCT O
Col1ɑ2 NOUN O
, PUNCT O
collagen NOUN O
type NOUN O
I NOUN O
ɑ NOUN O
2 NUM O
; PUNCT O
Emcn PROPN B-AC
, PUNCT O
endomucin NOUN B-LF
; PUNCT O
Epi PROPN O
, PUNCT O
epicardium NOUN O
; PUNCT O
Lox PROPN B-AC
, PUNCT O
lysyl NOUN B-LF
oxidase NOUN I-LF
; PUNCT O
LV PROPN O
, PUNCT O
left ADJ O
ventricular ADJ O
; PUNCT O
MI PROPN B-AC
, PUNCT O
myocardial ADJ B-LF
infarction NOUN I-LF
; PUNCT O
Myo PROPN O
, PUNCT O
myocardium NOUN O
; PUNCT O
NS PROPN O
, PUNCT O
non ADJ O
- PUNCT O
significant ADJ O
; PUNCT O
p4ha1 PROPN O
, PUNCT O
prolyl NOUN O
4 NUM O
- PUNCT O
hydroxylase NOUN O
subunit NOUN O
alpha-1 NOUN O
; PUNCT O
plod2 PROPN O
, PUNCT O
procollagen NOUN O
- PUNCT O
lysine,2 NOUN O
- PUNCT O
oxoglutarate NOUN O
5 NUM O
- PUNCT O
dioxygenase NOUN O
2 NUM O
; PUNCT O
Plod2b PROPN O
, PUNCT O
procollagen NOUN O
- PUNCT O
lysine,2 NOUN O
- PUNCT O
oxoglutarate NOUN O
5 NUM O
- PUNCT O
dioxygenase NOUN O
2b NUM O
; PUNCT O
qRT NOUN B-AC
- PUNCT B-AC
PCR NOUN B-AC
, PUNCT O
real ADJ B-LF
- PUNCT I-LF
time NOUN I-LF
quantitative ADJ I-LF
reverse ADJ I-LF
transcription NOUN I-LF
PCR NOUN I-LF
; PUNCT O
Tagln PROPN B-AC
, PUNCT O
transgelin NOUN B-LF
; PUNCT O
TAZ PROPN B-AC
, PUNCT O
transcriptional ADJ B-LF
coactivator NOUN I-LF
with ADP I-LF
PDZ NOUN I-LF
- PUNCT I-LF
binding VERB I-LF
motif NOUN I-LF
; PUNCT O
Timp1 PROPN B-AC
, PUNCT O
tissue NOUN B-LF
inhibitor NOUN I-LF
matrix NOUN I-LF
metalloproteinase NOUN I-LF
1 NUM I-LF
; PUNCT O
Vcam1 PROPN B-AC
, PUNCT O
vascular ADJ B-LF
cell NOUN I-LF
adhesion NOUN I-LF
molecule NOUN I-LF
1 NUM I-LF
; PUNCT O
Vegf PROPN O
, PUNCT O
vascular ADJ O
endothelial ADJ O
growth NOUN O
factor NOUN O
; PUNCT O
YAP PROPN B-AC
, PUNCT O
yes NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
protein NOUN I-LF
; PUNCT O
YAP PROPN B-AC
/ SYM B-AC
TAZ PROPN B-AC
- PUNCT B-AC
dKO PROPN B-AC
, PUNCT O
YAP PROPN B-LF
/ SYM I-LF
TAZ PROPN I-LF
double ADJ I-LF
knockout NOUN I-LF
. PUNCT O

BG PROPN B-AC
, PUNCT O
Bergmann PROPN B-LF
glia NOUN I-LF
; PUNCT O
E PROPN O
, PUNCT O
embryonic ADJ O
day NOUN O
; PUNCT O
GLA PROPN B-AC
, PUNCT O
granular ADJ B-LF
layer NOUN I-LF
astrocyte NOUN I-LF
; PUNCT O
GLAp PROPN B-AC
, PUNCT O
granular ADJ B-LF
layer NOUN I-LF
astrocyte NOUN I-LF
precursor NOUN I-LF
; PUNCT O
HetC PROPN B-AC
, PUNCT O
heterogeneous ADJ B-LF
clone NOUN I-LF
; PUNCT O
HomC PROPN B-AC
, PUNCT O
homogeneous ADJ B-LF
clone NOUN I-LF
; PUNCT O
MP PROPN B-AC
, PUNCT O
multiple ADJ O
progenitor NOUN O
; PUNCT O
P PROPN O
, PUNCT O
postnatal ADJ O
day NOUN O
; PUNCT O
PCLp PROPN B-AC
, PUNCT O
Purkinje PROPN B-LF
cell NOUN I-LF
layer NOUN I-LF
precursor NOUN I-LF
; PUNCT O
PWM PROPN B-AC
, PUNCT O
prospective ADJ B-LF
white ADJ I-LF
matter NOUN I-LF
; PUNCT O
WMA PROPN B-AC
, PUNCT O
white ADJ B-LF
matter NOUN I-LF
astrocyte NOUN I-LF
. PUNCT O

Abbreviations NOUN O
: PUNCT O
adjOR NOUN B-AC
, PUNCT O
adjusted ADJ B-LF
odds NOUN I-LF
ratio NOUN I-LF
; PUNCT O
CI NOUN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
ref NOUN O
, PUNCT O
reference NOUN O

NA PROPN B-AC
agents NOUN O
have VERB O
a DET O
high ADJ O
rate NOUN O
of ADP O
success NOUN O
in ADP O
suppressing VERB O
detectable ADJ O
viraemia NOUN O
, PUNCT O
but CCONJ O
do AUX O
not PART O
tackle VERB O
the DET O
liver NOUN O
reservoir NOUN O
of ADP O
virus NOUN O
( PUNCT O
in ADP O
the DET O
form NOUN O
of ADP O
covalently ADV B-LF
closed ADJ I-LF
circular ADJ I-LF
DNA NOUN I-LF
( PUNCT O
cccDNA NOUN B-AC
) PUNCT O
in ADP O
the DET O
nucleus NOUN O
of ADP O
infected ADJ O
hepatocytes NOUN O
[ PUNCT O
14 NUM O
] PUNCT O
) PUNCT O
, PUNCT O
so SCONJ O
most ADJ O
individuals NOUN O
are AUX O
committed VERB O
to ADP O
long ADJ O
- PUNCT O
term NOUN O
treatment NOUN O
. PUNCT O

Stress NOUN O
myocardial ADJ O
perfusion NOUN O
positron NOUN B-LF
emission NOUN I-LF
tomography NOUN I-LF
( PUNCT O
PET NOUN B-AC
) PUNCT O
allows VERB O
for ADP O
measurement NOUN O
of ADP O
absolute ADJ O
myocardial ADJ B-LF
blood NOUN I-LF
flow NOUN I-LF
( PUNCT O
MBF NOUN B-AC
) PUNCT O
and CCONJ O
quantification NOUN O
of ADP O
global ADJ O
left VERB O
ventricular ADJ O
coronary ADJ B-LF
flow NOUN I-LF
reserve NOUN I-LF
( PUNCT O
CFR NOUN B-AC
) PUNCT O
. PUNCT O
A DET O
CFR NOUN B-AC
< ADP O
2.0 NUM O
is AUX O
considered VERB O
impaired ADJ O
coronary ADJ O
vascular ADJ O
function NOUN O
, PUNCT O
and CCONJ O
it PRON O
is AUX O
associated VERB O
with ADP O
increased VERB O
cardiovascular ADJ O
risk NOUN O
. PUNCT O

The DET O
region NOUN O
of ADP O
Southeast PROPN B-LF
Tibet PROPN I-LF
shrublands NOUN I-LF
and CCONJ I-LF
meadows NOUN I-LF
( PUNCT O
STSM PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
accounted VERB O
for ADP O
43.4 NUM O
% NOUN O
of ADP O
the DET O
total ADJ O
area NOUN O
in ADP O
the DET O
Hengduan PROPN O
Mountain PROPN O
Hotspot PROPN O
, PUNCT O
was AUX O
at ADP O
a DET O
relatively ADV O
lower ADJ O
risk NOUN O
. PUNCT O

DAA NOUN B-AC
, PUNCT O
direct ADJ B-LF
anterior ADJ I-LF
approach NOUN I-LF
; PUNCT O
CAs PROPN B-AC
, PUNCT O
conventional ADJ B-LF
approaches NOUN I-LF
; PUNCT O
SD NOUN O
, PUNCT O
standard ADJ O
deviation NOUN O
; PUNCT O
MD NOUN B-AC
, PUNCT O
mean NOUN B-LF
difference NOUN I-LF
; PUNCT O
CI NOUN B-AC
, PUNCT O
confidence NOUN O
interval NOUN O
. PUNCT O

The DET O
activities NOUN O
of ADP O
antioxidant ADJ O
enzymes NOUN O
ascorbate NOUN B-LF
peroxidase NOUN I-LF
( PUNCT O
APX PROPN B-AC
) PUNCT O
, PUNCT O
guaiacol NOUN B-LF
peroxidase NOUN I-LF
( PUNCT O
GaPX NOUN B-AC
) PUNCT O
, PUNCT O
catalases NOUN B-LF
( PUNCT O
CAT NOUN B-AC
) PUNCT O
and CCONJ O
polyphenol NOUN B-LF
oxidases NOUN I-LF
( PUNCT O
PPO NOUN B-AC
) PUNCT O
were AUX O
measured VERB O
as ADP O
parameters NOUN O
of ADP O
antioxidant ADJ O
defence NOUN O
. PUNCT O

For ADP O
calculations NOUN O
of ADP O
total ADJ O
effectiveness NOUN O
among ADP O
vaccinees NOUN O
, PUNCT O
both PRON O
a DET O
mITT PROPN B-AC
approach NOUN O
and CCONJ O
an DET O
according VERB B-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
protocol NOUN I-LF
( PUNCT O
ATP PROPN B-AC
) PUNCT O
approach NOUN O
were AUX O
used VERB O
. PUNCT O

Values NOUN O
for ADP O
graphs NOUN O
( PUNCT O
B NOUN O
) PUNCT O
and CCONJ O
( PUNCT O
C NOUN O
) PUNCT O
are AUX O
listed VERB O
in ADP O
S1 PROPN O
Data PROPN O
. PUNCT O
ccd PROPN O
, PUNCT O
carotenoid NOUN O
cleavage NOUN O
dioxygenase NOUN O
; PUNCT O
d14 NOUN O
, PUNCT O
dwarf NOUN O
14 NUM O
; PUNCT O
EV PROPN B-AC
, PUNCT O
empty ADJ B-LF
vector NOUN I-LF
; PUNCT O
IAA PROPN B-AC
, PUNCT O
indole-3 NOUN B-LF
- PUNCT I-LF
acetic ADJ I-LF
acid NOUN I-LF
; PUNCT O
JA PROPN O
, PUNCT O
jasmonate NOUN O
; PUNCT O
JA PROPN B-AC
- PUNCT B-AC
Ile PROPN B-AC
, PUNCT O
jasmonic ADJ B-LF
acid NOUN I-LF
- PUNCT I-LF
isoleucine NOUN I-LF
; PUNCT O
kai2 PROPN O
, PUNCT O
karrikin NOUN O
insensitive ADJ O
2 NUM O
; PUNCT O
max2 NOUN O
, PUNCT O
more ADJ O
axillary ADJ O
growth NOUN O
2 NUM O
; PUNCT O
n.s PROPN O
. PUNCT O
not PART O
significant ADJ O
. PUNCT O

GFAP PROPN B-AC
, PUNCT O
a DET O
type NOUN O
III NUM O
intermediate ADJ B-LF
filament NOUN I-LF
( PUNCT O
IF PROPN B-AC
) PUNCT O
protein NOUN O
responsible ADJ O
for ADP O
the DET O
cytoskeletal ADJ O
structure NOUN O
of ADP O
glial ADJ O
cells NOUN O
, PUNCT O
is AUX O
critical ADJ O
in ADP O
maintaining VERB O
the DET O
IF PROPN B-AC
network NOUN O
of ADP O
activated ADJ O
astrocytes NOUN O
, PUNCT O
with ADP O
processes NOUN O
that PRON O
develop VERB O
thickened ADJ O
and CCONJ O
elongated ADJ O
shapes NOUN O
[ PUNCT O
9 NUM O
] PUNCT O
. PUNCT O

Briefly ADV O
, PUNCT O
in ADP O
three NUM O
separate ADJ O
trials NOUN O
, PUNCT O
using VERB O
two NUM O
- ADJ O
fold ADJ O
dilutions NOUN O
, PUNCT O
different ADJ O
concentrations NOUN O
of ADP O
HYD PROPN B-AC
, PUNCT O
DFMO PROPN B-AC
, PUNCT O
DA PROPN B-AC
, PUNCT O
CLF PROPN B-AC
, PUNCT O
and CCONJ O
ATV PROPN B-AC
were AUX O
prepared VERB O
in ADP O
the DET O
culture NOUN O
medium NOUN O
and CCONJ O
added VERB O
in ADP O
96 NUM O
- ADJ O
well NOUN O
plates NOUN O
in ADP O
triplicate NOUN O
with ADP O
1 NUM O
% NOUN O
parasitemia NOUN O
for ADP O
T. PROPN O
equi PROPN O
, PUNCT O
B. PROPN O
caballi PROPN O
and CCONJ O
B. PROPN O
divergens PROPN O
at ADP O
5 NUM O
% NOUN O
hematocrit NOUN B-LF
( PUNCT O
HCT PROPN B-AC
) PUNCT O
while SCONJ O
for ADP O
B. PROPN O
bigemina NOUN O
and CCONJ O
B. PROPN O
bovis NOUN O
using VERB O
2.5 NUM O
% NOUN O
HCT PROPN B-AC
. PUNCT O
Afterward ADV O
, PUNCT O
parasite NOUN O
cultures NOUN O
were AUX O
incubated VERB O
for ADP O
4 NUM O
consecutive ADJ O
days NOUN O
without ADP O
changing VERB O
medium NOUN O
at ADP O
37 NUM O
° NOUN O
C NOUN O
humidified VERB O
multi ADJ O
- ADJ O
gas ADJ O
incubator NOUN O
in ADP O
5 NUM O
% NOUN O
CO2 NOUN O
, PUNCT O
5 NUM O
% NOUN O
O2 NOUN O
, PUNCT O
and CCONJ O
90 NUM O
% NOUN O
N2 NOUN O
atmosphere NOUN O
. PUNCT O

Cells NOUN O
were AUX O
then ADV O
washed VERB O
in ADP O
1× NUM O
Perm PROPN O
/ SYM O
Wash PROPN O
buffer NOUN O
( PUNCT O
BD PROPN O
Pharmingen PROPN O
) PUNCT O
and CCONJ O
stained VERB O
with ADP O
interferon NOUN B-LF
gamma NOUN I-LF
( PUNCT O
IFN PROPN B-AC
- PUNCT B-AC
γ)-allophycocyanin NOUN O
or CCONJ O
tumor NOUN B-LF
necrosis NOUN I-LF
factor NOUN I-LF
alpha NOUN I-LF
( PUNCT O
TNF PROPN B-AC
- PUNCT B-AC
α)-allophycocyanin NOUN O
in ADP O
1× NUM O
Perm PROPN O
/ SYM O
Wash PROPN O
buffer NOUN O
for ADP O
45 NUM O
min NOUN O
at ADP O
4 NUM O
° NOUN O
C NOUN O
in ADP O
the DET O
dark NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
ARI PROPN B-AC
, PUNCT O
acute ADJ B-LF
respiratory ADJ I-LF
infection NOUN I-LF
; PUNCT O
CHW PROPN B-AC
, PUNCT O
community NOUN B-LF
health NOUN I-LF
worker NOUN I-LF
; PUNCT O
CI PROPN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
DHS PROPN B-AC
, PUNCT O
Demographic PROPN B-LF
and CCONJ I-LF
Health PROPN I-LF
Survey PROPN I-LF
; PUNCT O
GEE PROPN B-AC
, PUNCT O
generalized ADJ B-LF
estimating NOUN I-LF
equation NOUN I-LF
; PUNCT O
IMCI PROPN B-AC
, PUNCT O
Integrated PROPN B-LF
Management PROPN I-LF
of ADP I-LF
Childhood PROPN I-LF
Illness PROPN I-LF
; PUNCT O
PR PROPN B-AC
, PUNCT O
prevalance NOUN O
ratio NOUN O
. PUNCT O

Glycerophosphodiesterase NOUN B-LF
5 NUM I-LF
( PUNCT O
GDE5 PROPN B-AC
) PUNCT O
selectively ADV O
hydrolyses VERB O
glycerophosphocholine NOUN O
to ADP O
choline NOUN O
and CCONJ O
is AUX O
highly ADV O
expressed VERB O
in ADP O
type NOUN O
II NUM O
fiber NOUN O
- PUNCT O
rich ADJ O
skeletal ADJ O
muscles NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
M NOUN O
, PUNCT O
number NOUN O
of ADP O
occurrences NOUN O
of ADP O
adverse ADJ O
events NOUN O
; PUNCT O
NA PROPN B-AC
, PUNCT O
not PART B-LF
applicable ADJ I-LF

MPAP PROPN B-AC
was AUX O
estimated VERB O
as SCONJ O
the DET O
mean ADJ O
systolic ADJ O
right ADJ O
ventricle NOUN O
– PUNCT O
to ADP O
– PUNCT O
right ADJ O
atrium NOUN O
pressure NOUN O
gradient NOUN O
by ADP O
tracing VERB O
the DET O
TR NOUN B-AC
time NOUN B-LF
- PUNCT I-LF
velocity NOUN I-LF
integral NOUN I-LF
( PUNCT O
VTI PROPN B-AC
) PUNCT O
as SCONJ O
previously ADV O
validated VERB O
[ X O
11,20 NUM O
] PUNCT O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
ACE PROPN B-AC
- PUNCT B-AC
I PROPN B-AC
, PUNCT O
angiotensin NOUN B-LF
- PUNCT I-LF
converting VERB I-LF
enzyme NOUN I-LF
inhibitor NOUN I-LF
; PUNCT O
HR PROPN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT O
PY PROPN O
, PUNCT O
person NOUN O
- PUNCT O
year NOUN O
. PUNCT O

The DET O
diffusing VERB B-LF
capacity NOUN I-LF
of ADP I-LF
the DET I-LF
lungs NOUN I-LF
for ADP I-LF
carbon NOUN I-LF
monoxide NOUN I-LF
( PUNCT O
DLCO PROPN B-AC
) PUNCT O
was AUX O
significantly ADV O
lower ADJ O
in ADP O
the DET O
LC PROPN B-AC
with ADP O
IPF PROPN B-AC
group NOUN O
than ADP O
in ADP O
the DET O
LC PROPN B-AC
without ADP O
IPF PROPN B-AC
group NOUN O
( PUNCT O
83.7±20.8 NUM O
vs. ADP O
104.3±24.7 NUM O
; PUNCT O
P<0.001 NUM O
) PUNCT O
. PUNCT O

IPV NOUN B-AC
, PUNCT O
intimate ADJ B-LF
partner NOUN I-LF
violence NOUN I-LF
. PUNCT O

Those DET O
situations NOUN O
were AUX O
categorized VERB O
as ADP O
significant ADJ O
public ADJ O
health NOUN O
problems NOUN O
based VERB O
on ADP O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT O
WHO PROPN B-AC
) PUNCT O
criteria NOUN O
. PUNCT O

MI ADJ B-AC
provokes VERB O
a DET O
profound ADJ O
coordinated ADJ O
inflammatory ADJ O
response NOUN O
, PUNCT O
a DET O
process NOUN O
mediated VERB O
by ADP O
inflammatory ADJ O
bone NOUN B-LF
marrow NOUN I-LF
( PUNCT O
BM NOUN B-AC
) PUNCT O
and CCONJ O
peripheral ADJ B-LF
blood NOUN I-LF
( PUNCT O
PB NOUN B-AC
) PUNCT O
cells NOUN O
, PUNCT O
which PRON O
has AUX O
been AUX O
linked VERB O
to ADP O
the DET O
development NOUN O
of ADP O
end NOUN O
stage NOUN O
heart NOUN B-LF
failure NOUN I-LF
( PUNCT O
HF NOUN B-AC
) PUNCT O
, PUNCT O
a DET O
highly ADV O
frequent ADJ O
complication NOUN O
post X O
- ADJ O
MI ADJ B-AC
[ X O
1 NUM O
] PUNCT O
. PUNCT O

For ADP O
physical ADJ O
abuse NOUN O
, PUNCT O
significant ADJ O
associations NOUN O
were AUX O
also ADV O
observed VERB O
with ADP O
post ADJ B-LF
- ADJ I-LF
traumatic ADJ I-LF
stress NOUN I-LF
disorder NOUN I-LF
( PUNCT O
PTSD PROPN B-AC
) PUNCT O
and CCONJ O
panic NOUN O
disorder NOUN O
diagnoses NOUN O
( PUNCT O
Table NOUN O
S2 NUM O
) PUNCT O
. PUNCT O

It PRON O
has VERB O
been AUX O
shown VERB O
that SCONJ O
male NOUN B-LF
involvement NOUN I-LF
( PUNCT O
MI PROPN B-AC
) PUNCT O
in ADP O
ANC PROPN B-AC
and CCONJ O
PMTCT PROPN B-AC
can AUX O
increase VERB O
adherence NOUN O
to PART O
PMTCT PROPN B-AC
strategies NOUN O
, PUNCT O
and CCONJ O
thus ADV O
has VERB O
positive ADJ O
effects NOUN O
on ADP O
rates NOUN O
of ADP O
MTCT PROPN B-AC
and CCONJ O
infant NOUN O
survival NOUN O
[ PUNCT O
9 NUM O
, PUNCT O
28 NUM O
, PUNCT O
29 NUM O
] PUNCT O
, PUNCT O
however ADV O
, PUNCT O
the DET O
success NOUN O
of ADP O
implementing VERB O
programs NOUN O
aiming VERB O
to PART O
improve VERB O
MI PROPN B-AC
seems VERB O
to PART O
vary VERB O
in ADP O
different ADJ O
contexts NOUN O
[ PUNCT O
14 NUM O
] PUNCT O
. PUNCT O

Using VERB O
an DET O
internal ADJ O
validation NOUN O
set NOUN O
( PUNCT O
n NOUN O
= SYM O
1,993 NUM O
) PUNCT O
, PUNCT O
we PRON O
selected VERB O
the DET O
2 NUM O
top ADV O
- PUNCT O
performing VERB O
models NOUN O
; PUNCT O
these DET O
models NOUN O
were AUX O
then ADV O
evaluated VERB O
on ADP O
a DET O
held VERB O
- PUNCT O
out ADP O
internal ADJ O
test NOUN O
set NOUN O
based VERB O
on ADP O
area NOUN B-LF
under ADP I-LF
the DET I-LF
receiver NOUN I-LF
operating NOUN I-LF
characteristic NOUN I-LF
curve NOUN I-LF
( PUNCT O
AUC PROPN B-AC
) PUNCT O
, PUNCT O
sensitivity NOUN O
, PUNCT O
specificity NOUN O
, PUNCT O
and CCONJ O
positive ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
( PUNCT O
PPV NOUN B-AC
) PUNCT O
. PUNCT O
The DET O
final ADJ O
internal ADJ O
test NOUN O
was AUX O
performed VERB O
initially ADV O
on ADP O
a DET O
subset NOUN O
with SCONJ O
small ADJ O
pneumothorax NOUN O
excluded VERB O
( PUNCT O
as ADP O
in ADP O
training NOUN O
; PUNCT O
n NOUN O
= SYM O
1,701 NUM O
) PUNCT O
, PUNCT O
then ADV O
on ADP O
the DET O
full ADJ O
test NOUN O
set NOUN O
( PUNCT O
n NOUN O
= SYM O
1,990 NUM O
) PUNCT O
, PUNCT O
with SCONJ O
small ADJ O
pneumothorax NOUN O
included VERB O
as ADP O
positive ADJ O
. PUNCT O

Key ADJ O
drug NOUN O
resistance NOUN O
mutations NOUN O
were AUX O
defined VERB O
as ADP O
those PRON O
listed VERB O
by ADP O
the DET O
International PROPN B-LF
AIDS PROPN I-LF
Society PROPN I-LF
- PUNCT I-LF
USA PROPN I-LF
( PUNCT O
IAS PROPN B-AC
- PUNCT B-AC
USA PROPN B-AC
) PUNCT O
Drug PROPN O
Resistance PROPN O
Mutations PROPN O
Group PROPN O
[ PUNCT O
9 NUM O
] PUNCT O
. PUNCT O

We PRON O
performed VERB O
a DET O
GWAS NOUN B-AC
to PART O
identify VERB O
genetic ADJ O
loci NOUN O
influencing VERB O
liver NOUN O
function NOUN O
, PUNCT O
as SCONJ O
measured VERB O
by ADP O
concentrations NOUN O
of ADP O
alkaline ADJ B-LF
phosphatase NOUN I-LF
( PUNCT O
ALP PROPN B-AC
) PUNCT O
, PUNCT O
alanine NOUN O
transaminase NOUN O
( PUNCT O
ALT PROPN B-AC
) PUNCT O
, PUNCT O
gamma NOUN B-LF
- PUNCT I-LF
glutamyl NOUN I-LF
transferase NOUN I-LF
( PUNCT O
GGT PROPN B-AC
) PUNCT O
and CCONJ O
total ADJ B-LF
bilirubin NOUN I-LF
( PUNCT O
BIL NOUN B-AC
) PUNCT O
in ADP O
in ADP O
Korean ADJ O
study NOUN O
participants NOUN O
. PUNCT O

In ADP O
- PUNCT O
hospital NOUN O
mortality NOUN O
was AUX O
recorded VERB O
among ADP O
24.5 NUM O
% NOUN O
, PUNCT O
where SCONJ O
67.5 NUM O
% NOUN O
of ADP O
them PRON O
had VERB O
diagnosis NOUN O
of ADP O
STEMI PROPN B-AC
. PUNCT O
Very ADV O
few ADJ O
( PUNCT O
3.9 NUM O
% NOUN O
) PUNCT O
patients NOUN O
were AUX O
referred VERB O
for ADP O
surgical ADJ O
intervention NOUN O
of ADP O
coronary ADJ B-LF
artery NOUN I-LF
bypass NOUN I-LF
grafting NOUN I-LF
( PUNCT O
CABG PROPN B-AC
) PUNCT O
. PUNCT O
The DET O
most ADV O
common ADJ O
ACS PROPN B-AC
- PUNCT O
related VERB O
complication NOUN O
was AUX O
heart NOUN O
failure NOUN O
which PRON O
was AUX O
observed VERB O
in ADP O
about ADV O
42.4 NUM O
% NOUN O
of ADP O
the DET O
patients NOUN O
. PUNCT O

ApoA1 PROPN O
= VERB O
apolipoprotein NOUN O
A1 NUM O
; PUNCT O
CI NOUN B-AC
= VERB O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
Known ADJ O
CAD NOUN B-AC
= VERB O
previously ADV O
known VERB O
coronary ADJ B-LF
artery NOUN I-LF
disease NOUN I-LF
; PUNCT O
SBP PROPN B-AC
= VERB O
systolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
. PUNCT O

Lower ADJ O
panel NOUN O
: PUNCT O
primers NOUN O
and CCONJ O
plasmids NOUN O
for ADP O
allelic ADJ O
exchange NOUN O
as ADP O
well ADV O
as ADP O
resulting VERB O
strains NOUN O
. PUNCT O
fliC NOUN B-AC
, PUNCT O
flagellin NOUN B-LF
. PUNCT O

ADAR1 NOUN B-AC
, PUNCT O
adenosine NOUN B-LF
deaminase NOUN I-LF
acting VERB I-LF
on ADP I-LF
RNA NOUN I-LF
1 NUM I-LF
; PUNCT O
ADAR1KO PROPN B-AC
, PUNCT O
fully ADV B-LF
ADAR1 NOUN I-LF
- PUNCT I-LF
deficient ADJ I-LF
; PUNCT O
Cas9 PROPN B-AC
, PUNCT O
CRISPR PROPN B-LF
- PUNCT I-LF
associated VERB I-LF
9 NUM I-LF
; PUNCT O
chr1 PROPN O
, PUNCT O
human ADJ O
chromosome NOUN O
1 NUM O
; PUNCT O
CRISPR PROPN B-AC
, PUNCT O
clustered VERB B-LF
regularly ADV I-LF
interspaced VERB I-LF
short ADJ I-LF
palindromic ADJ I-LF
repeat NOUN I-LF
; PUNCT O
gRNA NOUN O
, PUNCT O
guide NOUN O
RNA NOUN O
; PUNCT O
IFN PROPN B-AC
, PUNCT O
interferon NOUN B-LF
; PUNCT O
IFN PROPN B-AC
A PROPN B-AC
/ SYM B-AC
D PROPN B-AC
, PUNCT O
recombinant ADJ B-LF
type NOUN I-LF
- PUNCT I-LF
I NOUN I-LF
IFN PROPN I-LF
- PUNCT I-LF
alpha NOUN I-LF
; PUNCT O
p150KO PROPN B-AC
, PUNCT O
selectively ADV B-LF
ADAR1p150 NOUN I-LF
- PUNCT I-LF
deficient ADJ I-LF
; PUNCT O
PAM PROPN O
, PUNCT O
protospacer NOUN O
adjacent ADJ O
motif NOUN O
. PUNCT O

Because SCONJ O
voluminous ADJ O
epicardial ADJ O
adipose ADJ O
tissue NOUN O
is AUX O
a DET O
risk NOUN O
factor NOUN O
for ADP O
coronary ADJ O
events NOUN O
, PUNCT O
there PRON O
is AUX O
a DET O
possibility NOUN O
that SCONJ O
the DET O
pericoronary ADJ B-LF
adipose ADJ I-LF
tissue NOUN I-LF
( PUNCT O
PCAT PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
is AUX O
a DET O
part NOUN O
of ADP O
epicardial ADJ O
adipose ADJ O
tissue NOUN O
, PUNCT O
acts VERB O
as ADP O
a DET O
risk NOUN O
factor NOUN O
by ADP O
supplying VERB O
oxLDL NOUN B-AC
to ADP O
the DET O
coronary ADJ O
arterial ADJ O
wall NOUN O
. PUNCT O

URI NOUN B-AC
: PUNCT O
Upper ADJ B-LF
respiratory ADJ I-LF
infection NOUN I-LF

Purified VERB O
recombinant ADJ O
PDO PROPN B-AC
from ADP O
P. PROPN O
aerophilum PROPN O
( PUNCT O
PaPDO PROPN B-AC
) PUNCT O
was AUX O
reacted VERB O
with ADP O
the DET O
fluorescent ADJ O
thiol NOUN O
- PUNCT O
reactive ADJ O
label NOUN O
7 NUM B-LF
- PUNCT I-LF
diethylamino-3-(4′-maleimidylphenyl)-4 NOUN I-LF
- PUNCT I-LF
methylcoumarin NOUN I-LF
( PUNCT O
CPM PROPN B-AC
) PUNCT O
under ADP O
denaturing VERB O
conditions NOUN O
in ADP O
the DET O
presence NOUN O
or CCONJ O
absence NOUN O
of ADP O
the DET O
reductant ADJ O
tris(2 NOUN B-LF
- PUNCT I-LF
carboxyethyl)phosphine NOUN I-LF
hydrochloride NOUN I-LF
( PUNCT O
TCEP PROPN B-AC
) PUNCT O
. PUNCT O
The DET O
denaturing VERB O
conditions NOUN O
ensure VERB O
that SCONJ O
all DET O
cysteines NOUN O
are AUX O
accessible ADJ O
to ADP O
the DET O
modifying VERB O
reagent NOUN O
. PUNCT O

It PRON O
has AUX O
been AUX O
well ADV O
known VERB O
that SCONJ O
the DET O
Protein PROPN B-LF
Kinase PROPN I-LF
C PROPN I-LF
( PUNCT O
PKC PROPN B-AC
) PUNCT O
can AUX O
regulate VERB O
the DET O
PI3K NOUN B-AC
/ SYM O
AKT NOUN O
pathway NOUN O
both CCONJ O
positively ADV O
[ X O
7 NUM O
] PUNCT O
and CCONJ O
negatively ADV O
[ X O
8 NUM O
] PUNCT O
, PUNCT O
depending VERB O
on ADP O
the DET O
isoform NOUN O
. PUNCT O

The DET O
Edinburgh PROPN O
Mouse PROPN O
Atlas PROPN O
Project PROPN O
also ADV O
provides VERB O
tools NOUN O
to PART O
map VERB O
in ADP B-LF
situ NOUN I-LF
hybridization NOUN I-LF
( PUNCT O
ISH NOUN B-AC
) PUNCT O
images NOUN O
directly ADV O
into ADP O
a DET O
three NUM B-LF
- ADJ I-LF
dimensional ADJ I-LF
( PUNCT O
3D ADJ B-AC
) PUNCT O
atlas NOUN O
[ PUNCT O
7 NUM O
] PUNCT O
. PUNCT O

The DET O
yield NOUN O
of ADP O
cervical ADJ B-LF
intraepithelial ADJ I-LF
neoplasia NOUN I-LF
grade NOUN I-LF
3 NUM I-LF
( PUNCT O
CIN3 NOUN B-AC
) PUNCT O
was AUX O
the DET O
same ADJ O
between ADP O
arms NOUN O
( PUNCT O
Table NOUN O
5 NUM O
) PUNCT O
. PUNCT O

BSS PROPN B-AC
: PUNCT O
Bristol PROPN B-LF
stool NOUN I-LF
scale NOUN I-LF
; PUNCT O
IQR PROPN O
: PUNCT O
interquartile ADJ O
range NOUN O
. PUNCT O

To ADP O
this DET O
end NOUN O
, PUNCT O
we PRON O
crossed VERB O
mTor PROPN O
and CCONJ O
regulatory ADJ B-LF
associated VERB I-LF
protein NOUN I-LF
of ADP I-LF
MTORc1 PROPN I-LF
( PUNCT O
Rptor PROPN B-AC
) PUNCT O
floxed ADJ O
mouse NOUN O
strains NOUN O
onto ADP O
Tsc1 PROPN O
floxed ADJ O
: PUNCT O
Cd11c PROPN O
- PUNCT O
Cre PROPN B-AC
mice NOUN O
, PUNCT O
thereby ADV O
generating VERB O
TSC1 PROPN B-AC
/ SYM O
mTORDC PROPN O
- PUNCT O
DKO PROPN O
and CCONJ O
TSC1 PROPN B-AC
/ SYM O
RaptorDC PROPN O
- PUNCT O
DKO PROPN O
mice NOUN O
, PUNCT O
respectively ADV O
. PUNCT O

Commercially ADV O
available ADJ O
Enzyme PROPN B-LF
- PUNCT I-LF
Linked PROPN I-LF
ImmunoSorbent PROPN I-LF
Assays NOUN I-LF
( PUNCT O
ELISAs PROPN B-AC
) PUNCT O
were AUX O
used VERB O
to PART O
measure VERB O
the DET O
concentration NOUN O
of ADP O
CSF PROPN B-AC
APP PROPN B-AC
, PUNCT O
NCAM-1 PROPN B-AC
, PUNCT O
L1CAM PROPN B-AC
. PUNCT O
Sandwich PROPN O
Duoset PROPN O
ELISA PROPN B-AC
development NOUN O
systems NOUN O
( PUNCT O
R&D PROPN O
Systems PROPN O
, PUNCT O
catalog NOUN O
# NOUN O
DY-850 NOUN O
, PUNCT O
and CCONJ O
DY-2408 PROPN O
respectively ADV O
; PUNCT O
Minneapolis PROPN O
, PUNCT O
MN PROPN O
) PUNCT O
were AUX O
used VERB O
to PART O
measure VERB O
APP PROPN B-AC
and CCONJ O
NCAM-1 PROPN B-AC
as SCONJ O
previously ADV O
described VERB O
[ PUNCT O
28 NUM O
] PUNCT O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
CCHHS PROPN B-AC
, PUNCT O
Cook PROPN B-LF
County PROPN I-LF
Health PROPN I-LF
& CCONJ I-LF
Hospitals PROPN I-LF
System PROPN I-LF
; PUNCT O
CTL PROPN B-AC
, PUNCT O
Clinical PROPN B-LF
Transition PROPN I-LF
Liaison PROPN I-LF
; PUNCT O
FQHC PROPN B-AC
, PUNCT O
federally ADV B-LF
qualified ADJ I-LF
health NOUN I-LF
center NOUN I-LF
; PUNCT O
PLWH PROPN B-AC
, PUNCT O
people NOUN B-LF
living VERB I-LF
with ADP I-LF
HIV PROPN I-LF
; PUNCT O
SHRT PROPN B-AC
, PUNCT O
Special PROPN B-LF
Health PROPN I-LF
Resources PROPN I-LF
for ADP I-LF
Texas PROPN I-LF
; PUNCT O
UPMC PROPN B-AC
, PUNCT O
University PROPN B-LF
of ADP I-LF
Pittsburgh PROPN I-LF
Medical PROPN I-LF
Center PROPN I-LF
. PUNCT O

The DET O
Tyramide PROPN B-LF
Signal PROPN I-LF
Amplification PROPN I-LF
( PUNCT O
TSA PROPN B-AC
) PUNCT O
kit NOUN O
( PUNCT O
Molecular ADJ O
probes NOUN O
) PUNCT O
was AUX O
used VERB O
to PART O
detect VERB O
HRP NOUN B-AC
activity NOUN O
as ADP O
per ADP O
manufacturer NOUN O
’s PART O
instructions NOUN O
. PUNCT O

Epstein PROPN B-LF
– PUNCT I-LF
Barr PROPN I-LF
virus NOUN I-LF
( PUNCT O
EBV PROPN B-AC
) PUNCT O
provides VERB O
a DET O
good ADJ O
candidate NOUN O
to PART O
address VERB O
these DET O
issues NOUN O
. PUNCT O

The DET O
2013 NUM O
Global PROPN B-LF
Burden PROPN I-LF
of ADP I-LF
Disease PROPN I-LF
( PUNCT O
GBD PROPN B-AC
2013 NUM O
) PUNCT O
estimated VERB O
DALYs NOUN B-AC
for ADP O
a DET O
number NOUN O
of ADP O
syndromes NOUN O
other ADJ O
than ADP O
HAIs PROPN B-AC
[ PUNCT O
28 NUM O
] PUNCT O
. PUNCT O

COR PROPN B-AC
, PUNCT O
crude ADJ B-LF
odds NOUN I-LF
ratio NOUN I-LF
; PUNCT O
AOR PROPN B-AC
, PUNCT O
adjusted VERB B-LF
odds NOUN I-LF
ratio NOUN I-LF
; PUNCT O
CI PROPN O
, PUNCT O
confidence NOUN O
interval NOUN O

We PRON O
also ADV O
evaluated VERB O
group NOUN O
differences NOUN O
, PUNCT O
defined VERB O
as ADP O
the DET O
differences NOUN O
in ADP O
Δchanges NOUN O
in ADP O
the DET O
Mediterranean ADJ O
group NOUN O
compared VERB O
with ADP O
Δchanges NOUN O
in ADP O
the DET O
low ADJ O
- PUNCT O
fat NOUN O
group NOUN O
, PUNCT O
which PRON O
included VERB O
the DET O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
( PUNCT O
CI NOUN B-AC
) PUNCT O
. PUNCT O

CS PROPN B-AC
, PUNCT O
complex ADJ B-LF
spikes NOUN I-LF
; PUNCT O
MI PROPN B-AC
, PUNCT O
mutual ADJ B-LF
information NOUN I-LF
; PUNCT O
SDF PROPN B-AC
, PUNCT O
spike NOUN B-LF
density NOUN I-LF
function NOUN I-LF
. PUNCT O

Previous ADJ O
resting ADJ O
- PUNCT O
state NOUN O
functional ADJ B-LF
MRI NOUN I-LF
( PUNCT O
fMRI NOUN B-AC
) PUNCT O
studies NOUN O
that PRON O
have AUX O
focused VERB O
on ADP O
time NOUN O
of ADP O
day NOUN O
have AUX O
yielded VERB O
inconsistent ADJ O
results NOUN O
, PUNCT O
potentially ADV O
because SCONJ O
of ADP O
small ADJ O
sample NOUN O
sizes NOUN O
[ PUNCT O
14,19–23 NUM O
] PUNCT O
. PUNCT O

Sex NOUN O
determination NOUN O
in ADP O
mammals NOUN O
is AUX O
controlled VERB O
by ADP O
the DET O
presence NOUN O
or CCONJ O
absence NOUN O
of ADP O
the DET O
Y PROPN O
- PUNCT O
linked VERB O
gene NOUN O
SRY PROPN B-AC
. PUNCT O
In ADP O
the DET O
developing VERB O
male NOUN O
( PUNCT O
XY PROPN O
) PUNCT O
gonad NOUN O
, PUNCT O
sex NOUN B-LF
- PUNCT I-LF
determining VERB I-LF
region NOUN I-LF
of ADP I-LF
the DET I-LF
Y PROPN I-LF
( PUNCT O
SRY PROPN B-AC
) PUNCT O
protein NOUN O
acts VERB O
to PART O
up ADV O
- PUNCT O
regulate VERB O
expression NOUN O
of ADP O
the DET O
related ADJ O
gene NOUN O
, PUNCT O
SOX9 PROPN O
, PUNCT O
a DET O
transcriptional ADJ O
regulator NOUN O
that PRON O
in ADP O
turn NOUN O
initiates VERB O
a DET O
downstream ADJ O
pathway NOUN O
of ADP O
testis NOUN O
development NOUN O
, PUNCT O
whilst SCONJ O
also ADV O
suppressing VERB O
ovary ADJ O
development NOUN O
. PUNCT O

MEDLINE PROPN O
, PUNCT O
Web PROPN O
of ADP O
Science PROPN O
, PUNCT O
Embase PROPN O
, PUNCT O
and CCONJ O
Cochrane PROPN O
Data PROPN O
of ADP O
Systematic PROPN O
Reviews PROPN O
were AUX O
searched VERB O
in ADP O
accordance NOUN O
with ADP O
the DET O
Preferred PROPN B-LF
Reporting PROPN I-LF
Items PROPN I-LF
for ADP I-LF
Systematic PROPN I-LF
Reviews PROPN I-LF
and CCONJ I-LF
Meta PROPN I-LF
- PROPN I-LF
Analyses PROPN I-LF
( PUNCT O
PRISMA PROPN B-AC
) PUNCT O
statement NOUN O
( PUNCT O
S1 PROPN O
Checklist PROPN O
) PUNCT O
. PUNCT O

PMMA NOUN B-AC
= PUNCT O
polymethyl ADJ B-LF
methacrylate NOUN I-LF
, PUNCT O
SD NOUN B-AC
= PUNCT O
standard ADJ B-LF
deviation NOUN I-LF
. PUNCT O

aHR NOUN O
, PUNCT O
adjusted ADJ O
hazard NOUN O
ratio NOUN O
; PUNCT O
cHR PROPN O
, PUNCT O
crude ADJ O
hazard NOUN O
ratio NOUN O
; PUNCT O
CVD NOUN B-AC
, PUNCT O
cardiovascular ADJ B-LF
disease NOUN I-LF
; PUNCT O
HELLP PROPN B-AC
, PUNCT O
hemolysis NOUN B-LF
, PUNCT I-LF
elevated ADJ I-LF
liver NOUN I-LF
enzymes NOUN I-LF
, PUNCT I-LF
and CCONJ I-LF
low ADJ I-LF
platelet NOUN I-LF
. PUNCT O

Another DET O
study NOUN O
with ADP O
Madin PROPN B-LF
- PUNCT I-LF
Darby PROPN I-LF
canine ADJ I-LF
kidney NOUN I-LF
II NUM I-LF
cells NOUN I-LF
overexpressing VERB O
bABCG2 NOUN B-AC
( PUNCT O
MDCKII PROPN B-AC
- PUNCT O
bABCG2 NOUN B-AC
) PUNCT O
also ADV O
demonstrated VERB O
a DET O
TCDD- NOUN B-AC
and CCONJ O
prochloraz NOUN O
- PUNCT O
mediated VERB O
activation NOUN O
of ADP O
AhR PROPN B-AC
induced VERB O
bABCG2 NOUN B-AC
mRNA NOUN O
expression NOUN O
and CCONJ O
efflux NOUN O
activity NOUN O
[ PUNCT O
29 NUM O
] PUNCT O
. PUNCT O

CR PROPN B-AC
, PUNCT O
Critically ADV B-LF
Endangered VERB I-LF
; PUNCT O
EN PROPN B-AC
, PUNCT O
Endangered VERB B-LF
; PUNCT O
LC PROPN B-AC
, PUNCT O
Least ADJ B-LF
Concern NOUN I-LF
; PUNCT O
NPA PROPN B-AC
, PUNCT O
Non PROPN B-LF
- PROPN I-LF
Protected VERB I-LF
Areas NOUN I-LF
; PUNCT O
NT PROPN B-AC
, PUNCT O
Near ADV B-LF
Threatened VERB I-LF
; PUNCT O
RA PROPN B-AC
, PUNCT O
Restricted VERB B-LF
Areas NOUN I-LF
; PUNCT O
SPA PROPN B-AC
, PUNCT O
Strictly ADV B-LF
Protected VERB I-LF
Areas NOUN I-LF
; PUNCT O
VU PROPN B-AC
, PUNCT O
Vulnerable ADJ B-LF
. PUNCT O

For ADP O
the DET O
transcriptional ADJ O
activation NOUN O
of ADP O
anti ADJ B-LF
- PUNCT I-LF
oxidant ADJ I-LF
response NOUN I-LF
element NOUN I-LF
( PUNCT O
ARE PROPN B-AC
) PUNCT O
, PUNCT O
the DET O
pARE PROPN O
- PUNCT O
Luc PROPN O
( PUNCT O
Promega PROPN O
, PUNCT O
Fitchburg PROPN O
, PUNCT O
WI PROPN O
) PUNCT O
DNA NOUN O
construct NOUN O
was AUX O
employed VERB O
here ADV O
. PUNCT O

Similarly ADV O
, PUNCT O
genetic ADJ O
and CCONJ O
Ab PROPN O
- ADJ O
mediated VERB O
blockade NOUN O
of ADP O
IL-10 PROPN B-AC
signaling NOUN O
decreases VERB O
the DET O
mortality NOUN O
rate NOUN O
and CCONJ O
brain NOUN O
virus NOUN O
load NOUN O
in ADP O
murine ADJ O
West PROPN B-LF
Nile PROPN I-LF
Virus PROPN I-LF
( PUNCT O
WNV)-infection NOUN B-AC
[ PUNCT O
31 NUM O
] PUNCT O
. PUNCT O

A DET O
score NOUN O
significantly ADV O
higher ADJ O
than ADP O
0 NUM O
indicates VERB O
a DET O
neural ADJ O
pattern NOUN O
distinct ADJ O
to ADP O
that DET O
memory NOUN O
is AUX O
present ADJ O
in ADP O
the DET O
vmPFC PROPN B-AC
. PUNCT O
RSA PROPN B-AC
, PUNCT O
representational ADJ B-LF
similarity NOUN I-LF
analysis NOUN I-LF
; PUNCT O
vmPFC PROPN B-AC
, PUNCT O
ventromedial ADJ B-LF
prefrontal ADJ I-LF
cortex NOUN I-LF
. PUNCT O

hlh-30 NOUN B-AC
, PUNCT O
basic ADJ B-LF
helix NOUN I-LF
– PUNCT I-LF
loop NOUN I-LF
– PUNCT I-LF
helix NOUN I-LF
transcription NOUN I-LF
factor NOUN I-LF
30 NUM I-LF
; PUNCT O
hlh-30(lf NOUN B-AC
) PUNCT O
, PUNCT O
loss NOUN O
- PUNCT O
of ADP O
- PUNCT O
function NOUN O
tm1978 NOUN B-AC
mutation NOUN O
hlh-30 NOUN B-AC
; PUNCT O
L1 PROPN B-AC
, PUNCT O
first ADJ B-LF
larval ADJ I-LF
stage NOUN I-LF
. PUNCT O

MA PROPN B-AC
, PUNCT O
motion NOUN B-LF
average NOUN I-LF
; PUNCT O
SPS PROPN B-AC
, PUNCT O
single ADJ B-LF
pattern NOUN I-LF
stabilization NOUN I-LF
; PUNCT O
TPMP PROPN B-AC
, PUNCT O
transparent ADJ B-LF
panorama NOUN I-LF
motion NOUN I-LF
paradigm NOUN I-LF
; PUNCT O
YTA PROPN O
, PUNCT O
yaw NOUN O
torque NOUN O
amplitude NOUN O
. PUNCT O

Statistical ADJ O
analyses NOUN O
were AUX O
performed VERB O
using VERB O
SAS PROPN O
version NOUN O
9.2 NUM O
( PUNCT O
SAS PROPN O
Institute PROPN O
, PUNCT O
Cary PROPN O
, PUNCT O
NC PROPN O
) PUNCT O
. PUNCT O
We PRON O
used VERB O
principal ADJ B-LF
component NOUN I-LF
analysis NOUN I-LF
( PUNCT O
PCA PROPN B-AC
) PUNCT O
as ADP O
a DET O
data NOUN O
reduction NOUN O
technique NOUN O
to PART O
capture VERB O
the DET O
maximum ADJ O
variation NOUN O
patterns NOUN O
in ADP O
the DET O
29 NUM O
cytokine NOUN O
levels NOUN O
measured VERB O
at ADP O
day NOUN O
one NUM O
in ADP O
few ADJ O
linearly ADV O
independent ADJ O
components.[10 NOUN O
] PUNCT O
PCA PROPN B-AC
summarizes VERB O
variation NOUN O
in ADP O
data NOUN O
without ADP O
any DET O
prior ADJ O
assumptions NOUN O
about ADP O
whether SCONJ O
the DET O
samples NOUN O
come VERB O
from ADP O
different ADJ O
treatment NOUN O
groups NOUN O
or CCONJ O
have VERB O
phenotypic ADJ O
differences NOUN O
, PUNCT O
thus ADV O
avoids VERB O
introducing VERB O
inherent ADJ O
bias.[10 NOUN O
] PUNCT O
PCA PROPN B-AC
was AUX O
carried VERB O
out ADP O
on ADP O
the DET O
correlation NOUN O
matrix NOUN O
of ADP O
the DET O
29 NUM O
cytokine NOUN O
measures NOUN O
at ADP O
baseline NOUN O
using VERB O
the DET O
“ PUNCT O
PRINCOMP PROPN O
” PUNCT O
procedure NOUN O
of ADP O
SAS PROPN O
. PUNCT O
The DET O
analysis NOUN O
generated VERB O
principal ADJ O
components NOUN O
with ADP O
a DET O
set NOUN O
of ADP O
eigenvalues NOUN O
and CCONJ O
eigenvectors NOUN O
. PUNCT O

ER NOUN B-AC
, PUNCT O
endoplasmic ADJ O
retitculum NOUN O
; PUNCT O
SA PROPN B-AC
, PUNCT O
spine NOUN B-LF
apparatus NOUN I-LF
; PUNCT O
SERCA PROPN B-AC
, PUNCT O
sarco NOUN B-LF
/ SYM I-LF
ER NOUN I-LF
calcium NOUN I-LF
- PUNCT I-LF
ATPase NOUN I-LF
. PUNCT O

DO VERB B-AC
, PUNCT O
H2 NOUN O
- PUNCT O
O NOUN O
; PUNCT O
KO PROPN B-AC
, PUNCT O
knockout NOUN B-LF
; PUNCT O
MOG PROPN B-AC
, PUNCT O
myelin NOUN B-LF
oligodendrocyte NOUN I-LF
glycoprotein NOUN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

For ADP O
the DET O
case NOUN O
of ADP O
coronavirus NOUN B-LF
disease NOUN I-LF
2019 NUM I-LF
( PUNCT O
COVID-19 NOUN B-AC
) PUNCT O
, PUNCT O
the DET O
presence NOUN O
of ADP O
an DET O
incubation NOUN O
period NOUN O
, PUNCT O
during ADP O
which PRON O
infected ADJ O
individuals NOUN O
carry VERB O
on ADP O
their PRON O
usual ADJ O
activities NOUN O
( PUNCT O
including VERB O
travel NOUN O
) PUNCT O
, PUNCT O
was AUX O
a DET O
major ADJ O
challenge NOUN O
for ADP O
screening NOUN O
controls NOUN O
at ADP O
airports NOUN O
[ PUNCT O
8 NUM O
] PUNCT O
. PUNCT O

EPO PROPN B-AC
, PUNCT O
erythropoietin NOUN B-LF
; PUNCT O
FGF23 PROPN B-AC
, PUNCT O
fibroblast NOUN B-LF
growth NOUN I-LF
factor NOUN I-LF
23 NUM I-LF
; PUNCT O
sTfR PROPN B-AC
, PUNCT O
soluble ADJ B-LF
transferrin NOUN I-LF
receptor NOUN I-LF
; PUNCT O
TSAT PROPN B-AC
, PUNCT O
transferrin NOUN B-LF
saturation NOUN I-LF
. PUNCT O

Several ADJ O
studies NOUN O
suggest VERB O
that SCONJ O
migration NOUN O
is AUX O
associated VERB O
with ADP O
increased VERB O
hypothalamic ADJ B-LF
– PUNCT I-LF
pituitary ADJ I-LF
– PUNCT I-LF
adrenal ADJ I-LF
( PUNCT O
HPA PROPN B-AC
) PUNCT O
axis NOUN O
function NOUN O
( PUNCT O
Meier PROPN O
and CCONJ O
Fivizzani PROPN O
1975 NUM O
; PUNCT O
Ramenofsky PROPN O
et X O
al X O
. PUNCT O
1999 NUM O
; PUNCT O
Wingfield PROPN O
2003 NUM O
; PUNCT O
Landys PROPN O
et X O
al X O
. PUNCT O
2004 NUM O
) PUNCT O
. PUNCT O

Diagnostic ADJ O
imaging NOUN O
includes VERB O
the DET O
use NOUN O
of ADP O
conventional ADJ O
and CCONJ O
diffusion NOUN O
- PUNCT O
based VERB O
MRI NOUN B-AC
, PUNCT O
with SCONJ O
the DET O
later ADJ O
capable ADJ O
of ADP O
identifying VERB O
ischemic ADJ O
HIE PROPN B-AC
lesions NOUN O
in ADP O
the DET O
acute ADJ O
phase NOUN O
, PUNCT O
several ADJ O
days NOUN O
earlier ADV O
than ADP O
the DET O
former ADJ O
. PUNCT O
[ X O
10,11 X O
] X O
Diffusion NOUN O
MRI NOUN B-AC
, PUNCT O
including VERB O
diffusion NOUN B-LF
- PUNCT I-LF
weighted VERB I-LF
imaging NOUN I-LF
( PUNCT O
DWI PROPN B-AC
) PUNCT O
and CCONJ O
quantitative ADJ O
apparent ADJ B-LF
diffusion NOUN I-LF
coefficient NOUN I-LF
( PUNCT O
ADC PROPN B-AC
) PUNCT O
mapping NOUN O
, PUNCT O
may AUX O
also ADV O
provide VERB O
additional ADJ O
early ADJ O
diagnostic ADJ O
and CCONJ O
prognostic ADJ O
information NOUN O
; PUNCT O
several ADJ O
studies NOUN O
report VERB O
an DET O
association NOUN O
between ADP O
reduced VERB O
ADC PROPN B-AC
values NOUN O
in ADP O
the DET O
posterior ADJ B-LF
limb NOUN I-LF
of ADP I-LF
the DET I-LF
internal ADJ I-LF
capsule NOUN I-LF
( PUNCT O
PLIC PROPN B-AC
) PUNCT O
as ADP O
well ADV O
as ADP O
an DET O
association NOUN O
between ADP O
reduced VERB O
ADC PROPN B-AC
values NOUN O
in ADP O
the DET O
basal ADJ B-LF
ganglia NOUN I-LF
and CCONJ I-LF
thalami NOUN I-LF
( PUNCT O
BGT PROPN B-AC
) PUNCT O
and CCONJ O
neurological ADJ O
sequelae NOUN O
. PUNCT O
[ X O
12–21 NUM O
] X O

RAP NOUN B-AC
, PUNCT O
rapamycin NOUN B-LF
. PUNCT O

Non ADJ O
- PUNCT O
proteolytic ADJ O
ubiquitination NOUN O
of ADP O
peroxisome NOUN B-LF
proliferator NOUN I-LF
- PUNCT I-LF
activated VERB I-LF
receptor NOUN I-LF
γ NOUN I-LF
( PUNCT O
PPARγ PROPN B-AC
) PUNCT O
by ADP O
the DET O
E3 NOUN B-AC
ligase NOUN O
Smurf1 PROPN O
suppresses VERB O
its PRON O
transcriptional ADJ O
activity NOUN O
and CCONJ O
plays VERB O
a DET O
critical ADJ O
role NOUN O
in ADP O
preventing VERB O
abnormal ADJ O
accumulation NOUN O
of ADP O
fatty ADJ O
acid NOUN O
in ADP O
the DET O
liver NOUN O
. PUNCT O

The DET O
2 NUM O
human ADJ O
oncogenic ADJ O
gammaherpesviruses NOUN O
Epstein PROPN B-LF
– PUNCT I-LF
Barr PROPN I-LF
virus PROPN I-LF
( PUNCT O
EBV PROPN B-AC
) PUNCT O
and CCONJ O
Kaposi PROPN B-LF
’s PART I-LF
sarcoma NOUN I-LF
- PUNCT I-LF
associated VERB I-LF
herpesvirus NOUN I-LF
( PUNCT O
KSHV PROPN B-AC
) PUNCT O
are AUX O
carried VERB O
by ADP O
a DET O
large ADJ O
proportion NOUN O
of ADP O
the DET O
adult NOUN O
population NOUN O
worldwide ADV O
and CCONJ O
pose VERB O
a DET O
significant ADJ O
risk NOUN O
of ADP O
infection NOUN O
- PUNCT O
associated VERB O
morbidity NOUN O
and CCONJ O
mortality NOUN O
, PUNCT O
especially ADV O
in ADP O
immunocompromised ADJ O
hosts NOUN O
[ X O
1–3 NUM O
] PUNCT O
. PUNCT O

The DET O
aim NOUN O
of ADP O
the DET O
study NOUN O
was AUX O
to PART O
investigate VERB O
the DET O
effect NOUN O
of ADP O
prenatal ADJ O
exposure NOUN O
factors NOUN O
, PUNCT O
including VERB O
socio ADJ O
- ADJ O
demographic ADJ O
, PUNCT O
behavioural ADJ O
, PUNCT O
dietary ADJ O
, PUNCT O
physical ADJ O
activity NOUN O
, PUNCT O
clinical ADJ O
and CCONJ O
environmental ADJ O
on ADP O
birth NOUN O
outcomes NOUN O
through ADP O
the DET O
mediation NOUN O
of ADP O
Favourable PROPN B-LF
Fetal PROPN I-LF
Growth PROPN I-LF
Conditions PROPN I-LF
( PUNCT O
FFGC PROPN B-AC
) PUNCT O
. PUNCT O

ALT PROPN B-AC
, PUNCT O
alanine NOUN B-LF
aminotransferase NOUN I-LF
; PUNCT O
APTT PROPN B-AC
, PUNCT O
activated VERB B-LF
partial ADJ I-LF
thromboplastin NOUN I-LF
time NOUN I-LF
; PUNCT O
AST PROPN B-AC
, PUNCT O
aspartate NOUN B-LF
aminotransferase NOUN I-LF
; PUNCT O
CKD PROPN O
, PUNCT O
chronic ADJ O
kidney NOUN O
disease NOUN O
; PUNCT O
COPD NOUN B-AC
, PUNCT O
chronic ADJ O
obstructive ADJ O
pulmonary ADJ O
disease NOUN O
; PUNCT O
PT NOUN B-AC
, PUNCT O
prothrombin NOUN B-LF
time NOUN I-LF
; PUNCT O
RR NOUN B-AC
, PUNCT O
respiratory ADJ B-LF
rate NOUN I-LF
; PUNCT O
T NOUN O
, PUNCT O
temperature NOUN O

In ADP O
a DET O
modeling VERB O
study NOUN O
, PUNCT O
Cora PROPN O
Bernard PROPN O
and CCONJ O
colleagues NOUN O
examine VERB O
the DET O
cost NOUN O
- NOUN O
effectiveness NOUN O
of ADP O
opioid ADJ B-LF
agonist NOUN I-LF
therapy NOUN I-LF
( PUNCT O
OAT PROPN B-AC
) PUNCT O
, PUNCT O
needle NOUN O
- NOUN O
syringe NOUN O
exchange NOUN O
programs NOUN O
( PUNCT O
NSP PROPN B-AC
) PUNCT O
, PUNCT O
screening NOUN O
and CCONJ O
intensive ADJ O
antiretroviral ADJ O
therapy NOUN O
programs NOUN O
( PUNCT O
Test PROPN B-AC
& CCONJ B-AC
Treat VERB B-AC
) PUNCT O
, PUNCT O
and CCONJ O
oral ADJ O
HIV PROPN O
pre NOUN B-LF
- NOUN I-LF
exposure NOUN I-LF
prophylaxis NOUN I-LF
( PUNCT O
PrEP PROPN B-AC
) PUNCT O
for ADP O
prevention NOUN O
of ADP O
HIV PROPN O
in ADP O
people NOUN O
who PRON O
inject VERB O
drugs NOUN O
. PUNCT O

Genetic ADJ B-LF
distance NOUN I-LF
was AUX O
estimated VERB O
between ADP O
a DET O
pair NOUN O
of ADP O
inbred ADJ O
lines NOUN O
from ADP O
6081 NUM O
markers NOUN O
using VERB O
Roger PROPN O
’s PART O
genetic ADJ B-LF
distance NOUN I-LF
( PUNCT O
GD PROPN B-AC
) PUNCT O
in ADP O
powerMaker PROPN O
version NOUN O
3.25 NUM O
[ PUNCT O
40 NUM O
] PUNCT O
. PUNCT O

PHA PROPN B-AC
: PUNCT O
Phytohemagglutinin NOUN B-LF
; PUNCT O
uRBC NOUN O
: PUNCT O
Uninfected ADJ O
erythrocytes NOUN O
; PUNCT O
PNG PROPN B-AC
: PUNCT O
Papua PROPN B-LF
New PROPN I-LF
Guinea PROPN I-LF
; PUNCT O
N NOUN O
: PUNCT O
Non ADJ O
- ADJ O
malaria ADJ O
infected ADJ O
women NOUN O
; PUNCT O
AUS PROPN B-AC
: PUNCT O
Australia PROPN B-LF

Statistical ADJ O
analysis NOUN O
performed VERB O
with ADP O
ANOVA PROPN O
. PUNCT O
CI NOUN B-AC
: PUNCT O
Cavitation NOUN B-LF
Index PROPN I-LF
; PUNCT O
Gem NOUN B-AC
5 NUM B-AC
μM NOUN B-AC
: PUNCT O
Gemcitabine NOUN B-LF
at ADP I-LF
a DET I-LF
concentration NOUN I-LF
of ADP I-LF
5 NUM I-LF
μM NOUN I-LF

The DET O
RalBD PROPN B-AC
( PUNCT O
aa NOUN O
397–518 NUM O
of ADP O
human ADJ O
RalBP1 PROPN O
) PUNCT O
was AUX O
subcloned VERB O
into ADP O
pGEX4T-1 PROPN O
( PUNCT O
Amersham PROPN O
Biosciences PROPN O
) PUNCT O
and CCONJ O
pEGFP PROPN O
- PUNCT O
C1 PROPN O
. PUNCT O
For ADP O
short ADJ B-LF
hairpin NOUN I-LF
RNA NOUN I-LF
( PUNCT O
shRNA NOUN B-AC
) PUNCT O
knockdown NOUN O
of ADP O
RalBP1 PROPN O
, PUNCT O
pSUPER PROPN O
RalBP1 PROPN O
was AUX O
generated VERB O
by ADP O
annealing VERB O
oligonucleotides NOUN O
containing VERB O
nt NOUN O
666–684 NUM O
of ADP O
rat NOUN O
RalBP1 PROPN O
cDNA NOUN O
( PUNCT O
U28830 PROPN O
; PUNCT O
critical ADJ O
19 NUM O
nt NOUN O
, PUNCT O
GCACGGCATGAAATGTGAA PROPN O
) PUNCT O
and CCONJ O
subcloning VERB O
into ADP O
pSUPER.gfp/neo NOUN O
( PUNCT O
OligoEngine PROPN O
) PUNCT O
. PUNCT O
pSUPER PROPN O
RalA PROPN O
was AUX O
generated VERB O
using VERB O
oligonucleotides NOUN O
containing VERB O
nt NOUN O
402–420 NUM O
of ADP O
rat NOUN O
RalA PROPN O
cDNA NOUN O
( PUNCT O
NM_031093 NOUN O
; PUNCT O
AAGGCAGGTTTCTGTAGAA PROPN O
) PUNCT O
. PUNCT O
pSuper PROPN O
RalA PROPN O
scrambled VERB O
was AUX O
generated VERB O
using VERB O
oligonucleotides NOUN O
containing VERB O
the DET O
following VERB O
sequence NOUN O
( PUNCT O
GAACGAGTGTCTGTAAGTA PROPN O
) PUNCT O
. PUNCT O
shRNA NOUN B-AC
- PUNCT O
resistant ADJ O
RalA PROPN O
rescue NOUN O
construct NOUN O
was AUX O
generated VERB O
by ADP O
introducing VERB O
point NOUN O
mutations NOUN O
into ADP O
pcDNA3.1 NOUN O
- PUNCT O
HA PROPN O
RalA PROPN O
WT PROPN B-AC
using VERB O
QuickChange PROPN O
kit NOUN O
. PUNCT O

More ADJ O
processed VERB O
AR42J PROPN O
revealed VERB O
higher ADJ O
efficacy NOUN O
in ADP O
siRNA NOUN O
transfection NOUN O
indicated VERB O
by ADP O
reduced VERB O
expression NOUN O
of ADP O
Glo NOUN B-AC
- PUNCT B-AC
I NOUN B-AC
in ADP O
qRT NOUN B-AC
- PUNCT B-AC
PCR NOUN B-AC
. PUNCT O
CN NOUN B-AC
: PUNCT O
cerulein NOUN B-LF
, PUNCT O
Dexa PROPN B-AC
: PUNCT O
dexamethasone NOUN B-LF
, PUNCT O
Glo NOUN B-AC
- PUNCT B-AC
I NOUN B-AC
: PUNCT O
Glyoxalase NOUN B-LF
- PUNCT I-LF
I. PUNCT I-LF

In ADP O
newly ADV O
diagnosed VERB O
people NOUN B-LF
with ADP I-LF
Parkinson PROPN I-LF
’s PART I-LF
( PUNCT O
PwP PROPN B-AC
) PUNCT O
, PUNCT O
the DET O
response NOUN O
to PART O
a DET O
single ADJ O
drug NOUN O
intake NOUN O
may AUX O
last VERB O
for ADP O
several ADJ O
hours NOUN O
, PUNCT O
whereas SCONJ O
with ADP O
the DET O
progression NOUN O
of ADP O
the DET O
disease NOUN O
the DET O
drug NOUN O
’s PART O
effect NOUN O
is AUX O
shortened VERB O
( PUNCT O
4 NUM O
hours NOUN O
or CCONJ O
less ADJ O
) PUNCT O
, PUNCT O
and CCONJ O
patients NOUN O
need VERB O
to PART O
decrease VERB O
intervals NOUN O
between ADP O
doses NOUN O
and/or CCONJ O
increase VERB O
the DET O
dosages NOUN O
[ X O
5,6 NUM O
] X O
” PUNCT O
. PUNCT O

Shown VERB O
is AUX O
( PUNCT O
a DET O
) PUNCT O
a DET O
Jitter NOUN O
plot NOUN O
illustrating VERB O
the DET O
distribution NOUN O
of ADP O
individual ADJ O
propensity NOUN O
scores NOUN O
and CCONJ O
( PUNCT O
b X O
) PUNCT O
a DET O
line NOUN O
plot NOUN O
displaying VERB O
the DET O
absolute ADJ O
standardized ADJ B-LF
mean NOUN I-LF
differences NOUN I-LF
( PUNCT O
SMD NOUN B-AC
) PUNCT O
of ADP O
each DET O
matching VERB O
covariate NOUN O
. PUNCT O

UCP-1 NOUN B-AC
immunostaining NOUN O
in ADP O
sections NOUN O
of ADP O
inguinal ADJ O
white ADJ O
adipose ADJ O
tissue NOUN O
( PUNCT O
ingWAT NOUN O
) PUNCT O
obtained VERB O
from ADP O
mice NOUN O
after ADP O
treatment NOUN O
with ADP O
vehicle NOUN O
, PUNCT O
rosiglitazone NOUN B-LF
( PUNCT O
RSG PROPN B-AC
, PUNCT O
4 NUM O
mg NOUN O
/ SYM O
kg NOUN O
/ SYM O
d NOUN O
) PUNCT O
, PUNCT O
or CCONJ O
QG-16 PROPN O
( PUNCT O
40 NUM O
mg NOUN O
/ SYM O
kg NOUN O
/ SYM O
d NOUN O
) PUNCT O
for ADP O
two NUM O
weeks NOUN O
. PUNCT O

Since SCONJ O
time NOUN B-LF
to ADP I-LF
progression NOUN I-LF
( PUNCT O
TTP PROPN B-AC
) PUNCT O
was AUX O
uncensored ADJ O
, PUNCT O
we PRON O
were AUX O
able ADJ O
to ADP O
use VERB O
( PUNCT O
multivariate ADJ O
) PUNCT O
linear ADJ O
regression NOUN O
models NOUN O
to ADP O
relate VERB O
TTP PROPN B-AC
to ADP O
the DET O
molecular ADJ O
and CCONJ O
clinical ADJ O
variables NOUN O
. PUNCT O

Because SCONJ O
Dilp-2 NOUN B-AC
is AUX O
normally ADV O
expressed VERB O
in ADP O
the DET O
IPCs NOUN B-AC
[ X O
42,43 NUM O
] X O
and CCONJ O
not PART O
BBB PROPN B-AC
( PUNCT O
blood NOUN B-LF
– PUNCT I-LF
brain NOUN I-LF
barrier NOUN I-LF
) PUNCT O
glia NOUN O
, PUNCT O
this PRON O
suggests VERB O
that SCONJ O
Dilp-2 NOUN B-AC
is AUX O
required VERB O
in ADP O
IPCs NOUN B-AC
for ADP O
neuroblast ADJ O
reactivation NOUN O
in ADP O
the DET O
brain NOUN O
. PUNCT O

Recrudescent ADJ O
infections NOUN O
( PUNCT O
estimated VERB O
by ADP O
the DET O
PCR NOUN O
- PUNCT O
corrected VERB O
failure NOUN O
rate NOUN O
, PUNCT O
not PART O
shown VERB O
) PUNCT O
were AUX O
assumed VERB O
to PART O
reappear VERB O
uniformly ADV O
throughout ADP O
the DET O
observation NOUN O
period NOUN O
. PUNCT O
( PUNCT O
B NOUN O
) PUNCT O
Example NOUN O
simulations NOUN O
of ADP O
placental ADJ O
prevalence NOUN O
by ADP O
week NOUN O
of ADP O
gestation NOUN O
in ADP O
the DET O
absence NOUN O
of ADP O
intervention NOUN O
, PUNCT O
and CCONJ O
where SCONJ O
sulphadoxine NOUN B-LF
- PUNCT I-LF
pyrimethamine NOUN I-LF
is AUX O
given VERB O
at ADP O
17 NUM O
, PUNCT O
25 NUM O
, PUNCT O
and CCONJ O
32 NUM O
wk NOUN O
gestation NOUN O
at ADP O
the DET O
different ADJ O
levels NOUN O
of ADP O
resistance NOUN O
. PUNCT O
( PUNCT O
C NOUN O
) PUNCT O
How SCONJ O
efficacy NOUN O
of ADP O
IPTp PROPN B-AC
- PUNCT B-AC
SP PROPN B-AC
against ADP O
LBW PROPN B-AC
is AUX O
assumed VERB O
to PART O
vary VERB O
by ADP O
resistance NOUN O
category NOUN O
and CCONJ O
transmission NOUN O
intensity NOUN O
( PUNCT O
based VERB O
on ADP O
changes NOUN O
in ADP O
the DET O
estimated VERB O
average ADJ O
time NOUN O
spent VERB O
infected VERB O
) PUNCT O
. PUNCT O

g X O
SFA NOUN B-AC
, PUNCT O
Saturated ADJ B-LF
fatty ADJ I-LF
acids NOUN I-LF
. PUNCT O

The DET O
objective NOUN O
of ADP O
this DET O
study NOUN O
is AUX O
to PART O
determine VERB O
the DET O
publication NOUN O
rate NOUN O
of ADP O
efficacy NOUN O
trials NOUN O
submitted VERB O
to PART O
the DET O
Food PROPN B-LF
and CCONJ I-LF
Drug PROPN I-LF
Administration PROPN I-LF
( PUNCT O
FDA PROPN B-AC
) PUNCT O
in ADP O
approved VERB O
New PROPN B-LF
Drug PROPN I-LF
Applications PROPN I-LF
( PUNCT O
NDAs PROPN B-AC
) PUNCT O
and CCONJ O
to PART O
compare VERB O
the DET O
trial NOUN O
characteristics NOUN O
as SCONJ O
reported VERB O
by ADP O
the DET O
FDA PROPN B-AC
with ADP O
those PRON O
reported VERB O
in ADP O
publications NOUN O
. PUNCT O

High ADJ O
expectations NOUN O
have AUX O
recently ADV O
been AUX O
placed VERB O
on ADP O
the DET O
development NOUN O
and CCONJ O
validation NOUN O
of ADP O
a DET O
minimally ADV B-LF
invasive ADJ I-LF
autopsy NOUN I-LF
( PUNCT O
MIA PROPN B-AC
) PUNCT O
tool NOUN O
[ PUNCT O
6 NUM O
] PUNCT O
, PUNCT O
an DET O
approach NOUN O
based VERB O
on ADP O
postmortem ADJ O
sampling NOUN O
of ADP O
key ADJ O
organs NOUN O
using VERB O
needle NOUN O
biopsies NOUN O
. PUNCT O

AMPK PROPN B-AC
, PUNCT O
AMP PROPN B-LF
- PUNCT I-LF
activated VERB I-LF
protein NOUN I-LF
kinase NOUN I-LF
; PUNCT O
KO PROPN B-AC
, PUNCT O
knockout NOUN B-LF
; PUNCT O
mTOR PROPN B-AC
, PUNCT O
mammalian ADJ B-LF
target NOUN I-LF
- PUNCT I-LF
of ADP I-LF
- PUNCT I-LF
rapamycin NOUN I-LF
; PUNCT O
ULK1 PROPN B-AC
, PUNCT O
unc-51 NOUN O
- PUNCT O
like ADJ O
autophagy NOUN O
activating VERB O
kinase NOUN O
1 NUM O
. PUNCT O

AOR PROPN B-AC
, PUNCT O
adjusted VERB B-LF
odds NOUN I-LF
ratio NOUN I-LF
; PUNCT O
OR PROPN O
, PUNCT O
odds NOUN O
ratio NOUN O
; PUNCT O
UBL PROPN B-AC
, PUNCT O
Unite PROPN B-LF
for ADP I-LF
a DET I-LF
Better PROPN I-LF
Life PROPN I-LF
. PUNCT O

Two NUM O
fundamental ADJ O
mechanisms NOUN O
, PUNCT O
namely ADV O
the DET O
homologous ADJ B-LF
recombination NOUN I-LF
( PUNCT O
HR NOUN B-AC
) PUNCT O
and CCONJ O
the DET O
non ADJ O
- PUNCT O
homologous ADJ O
- PUNCT O
end NOUN O
joining NOUN O
( PUNCT O
NHEJ PROPN B-AC
) PUNCT O
pathways NOUN O
are AUX O
involved VERB O
in ADP O
repair NOUN O
of ADP O
DSBs NOUN B-AC
[ PUNCT O
17,18 NUM O
] PUNCT O
. PUNCT O

CSF PROPN B-AC
- PUNCT B-AC
cN NOUN B-AC
, PUNCT O
cerebrospinal ADJ B-LF
fluid NOUN I-LF
- PUNCT I-LF
contacting VERB I-LF
neuron NOUN I-LF
; PUNCT O
hpf NOUN B-AC
, PUNCT O
hours NOUN B-LF
post ADP I-LF
fertilization NOUN I-LF
. PUNCT O

Thus ADV O
, PUNCT O
even ADV O
non ADJ O
- ADJ O
obstructive ADJ O
kidney NOUN O
stones NOUN O
in ADP O
cats NOUN O
affect VERB O
the DET O
rate NOUN O
of ADP O
chronic ADJ B-LF
kidney NOUN I-LF
disease NOUN I-LF
( PUNCT O
CKD PROPN B-AC
) PUNCT O
progression NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

TMA NOUN B-AC
= PUNCT O
Thrombotic ADJ B-LF
microangiopathy NOUN I-LF
; PUNCT O
eGFR NOUN B-AC
= PUNCT O
estimated VERB B-LF
glomerular ADJ I-LF
filtration NOUN I-LF
rate NOUN I-LF
; PUNCT O
SE NOUN O
= PUNCT O
standard ADJ O
error NOUN O
. PUNCT O

DEG PROPN B-AC
, PUNCT O
differentially ADV B-LF
expressed VERB I-LF
gene NOUN I-LF
; PUNCT O
GO PROPN B-AC
, PUNCT O
gene NOUN B-LF
ontology NOUN I-LF
. PUNCT O

CD4 PROPN B-AC
, PUNCT O
cluster NOUN B-LF
of ADP I-LF
differentiation NOUN I-LF
4 NUM I-LF
; PUNCT O
CD25 PROPN B-AC
, PUNCT O
cluster NOUN B-LF
of ADP I-LF
differentiation NOUN I-LF
25 NUM I-LF
; PUNCT O
FACS PROPN O
, PUNCT O
fluorescence NOUN O
- PUNCT O
activated VERB O
cell NOUN O
sorting NOUN O
; PUNCT O
Foxp3 PROPN B-AC
, PUNCT O
forkhead NOUN B-LF
box NOUN I-LF
P3 NOUN I-LF
; PUNCT O
GMFI PROPN B-AC
, PUNCT O
geometric ADJ B-LF
mean NOUN I-LF
fluorescence NOUN I-LF
intensity NOUN I-LF
; PUNCT O
IL-4Rα PROPN B-AC
, PUNCT O
interleukin-4 NOUN O
receptor NOUN O
alpha NOUN O
; PUNCT O
iTreg PROPN B-AC
, PUNCT O
induced VERB B-LF
Treg PROPN I-LF
; PUNCT O
NS PROPN B-AC
, PUNCT O
not PART B-LF
significant ADJ I-LF
; PUNCT O
rIL-4 PROPN B-AC
, PUNCT O
recombinant ADJ O
interleukin-4 NOUN O
; PUNCT O
TCR PROPN O
, PUNCT O
T NOUN O
- PUNCT O
cell NOUN O
receptor NOUN O
; PUNCT O
TGFβ PROPN O
, PUNCT O
transforming VERB O
growth NOUN O
factor NOUN O
beta NOUN O
; PUNCT O
Treg PROPN B-AC
, PUNCT O
regulatory ADJ B-LF
T. NOUN I-LF

Lateral ADJ O
flow NOUN O
urine NOUN O
lipoarabinomannan NOUN B-LF
( PUNCT O
LAM PROPN B-AC
) PUNCT O
tests NOUN O
could AUX O
offer VERB O
important ADJ O
new ADJ O
opportunities NOUN O
for ADP O
the DET O
early ADJ O
detection NOUN O
of ADP O
tuberculosis NOUN B-LF
( PUNCT O
TB PROPN B-AC
) PUNCT O
. PUNCT O
The DET O
currently ADV O
licensed VERB O
LAM PROPN B-AC
test NOUN O
, PUNCT O
Alere PROPN O
Determine PROPN O
TB PROPN B-AC
LAM PROPN B-AC
Ag PROPN O
( PUNCT O
‘ PUNCT O
LF PROPN O
- PUNCT O
LAM PROPN B-AC
’ PUNCT O
) PUNCT O
, PUNCT O
performs VERB O
best ADV O
in ADP O
the DET O
sickest ADJ O
people NOUN B-LF
living VERB I-LF
with ADP I-LF
HIV PROPN I-LF
( PUNCT O
PLHIV PROPN B-AC
) PUNCT O
. PUNCT O
However ADV O
, PUNCT O
the DET O
technology NOUN O
continues VERB O
to PART O
improve VERB O
, PUNCT O
with ADP O
newer ADJ O
LAM PROPN B-AC
tests NOUN O
, PUNCT O
such ADJ O
as ADP O
Fujifilm PROPN O
SILVAMP PROPN O
TB PROPN B-AC
LAM PROPN B-AC
( PUNCT O
‘ PUNCT O
SILVAMP PROPN O
- PUNCT O
LAM PROPN B-AC
’ PUNCT O
) PUNCT O
showing VERB O
improved ADJ O
sensitivity NOUN O
, PUNCT O
including VERB O
amongst ADP O
HIV PROPN O
- PUNCT O
negative ADJ O
patients NOUN O
. PUNCT O

The DET O
outbreak NOUN O
of ADP O
COVID-19 PROPN B-AC
was AUX O
first ADV O
begun VERB O
in ADP O
Wuhan PROPN O
, PUNCT O
Hubei PROPN O
state NOUN O
of ADP O
China PROPN O
and CCONJ O
was AUX O
first ADV O
reported VERB O
by ADP O
the DET O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT O
WHO PROPN B-AC
) PUNCT O
on ADP O
the DET O
31st NOUN O
December PROPN O
2019 NUM O
and CCONJ O
announced VERB O
as ADP O
a DET O
global ADJ O
pandemic NOUN O
on ADP O
30th NUM O
January PROPN O
2020 NUM O
[ PUNCT O
2 NUM O
] PUNCT O
. PUNCT O

We PRON O
therefore ADV O
chose VERB O
to PART O
identify VERB O
important ADJ O
explanatory ADJ O
variables NOUN O
directly ADV O
in ADP O
a DET O
geographically ADV B-LF
weighted VERB I-LF
regression NOUN I-LF
( PUNCT O
GWR PROPN B-AC
) PUNCT O
model NOUN O
. PUNCT O

Psychosocial ADJ O
factors NOUN O
most ADV O
strongly ADV O
associated VERB O
with ADP O
serious ADJ O
injury NOUN O
were AUX O
being AUX O
bullied VERB O
( PUNCT O
odds NOUN B-LF
ratio NOUN I-LF
[ X O
OR PROPN B-AC
] X O
2.45 NUM O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN O
1.93 NUM O
to PART O
3.13 NUM O
, PUNCT O
p NOUN O
< NOUN O
0.001 NUM O
) PUNCT O
, PUNCT O
drug NOUN O
use NOUN O
( PUNCT O
OR PROPN B-AC
2.08 NUM O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN O
1.73 NUM O
to PART O
2.49 NUM O
, PUNCT O
p NOUN O
< NOUN O
0.001 NUM O
) PUNCT O
, PUNCT O
attempting VERB O
suicide NOUN O
( PUNCT O
OR PROPN B-AC
1.78 NUM O
, PUNCT O
CI NOUN O
1.55 NUM O
to PART O
2.04 NUM O
, PUNCT O
p NOUN O
< NOUN O
0.001 NUM O
) PUNCT O
, PUNCT O
being AUX O
too ADV O
worried ADJ O
to PART O
sleep VERB O
( PUNCT O
OR PROPN B-AC
1.80 NUM O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN O
1.54 NUM O
to PART O
2.10 NUM O
, PUNCT O
p NOUN O
< NOUN O
0.001 NUM O
) PUNCT O
, PUNCT O
feeling VERB O
lonely ADJ O
( PUNCT O
OR PROPN B-AC
1.61 NUM O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN O
1.37 NUM O
to PART O
1.89 NUM O
, PUNCT O
p NOUN O
< NOUN O
0.001 NUM O
) PUNCT O
, PUNCT O
and CCONJ O
going VERB O
hungry ADJ O
( PUNCT O
OR PROPN B-AC
1.61 NUM O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN O
1.30 NUM O
to PART O
2.01 NUM O
, PUNCT O
p NOUN O
< NOUN O
0.001 NUM O
) PUNCT O
. PUNCT O

Then ADV O
, PUNCT O
in ADP O
1996 NUM O
, PUNCT O
antiretroviral ADJ B-LF
therapy NOUN I-LF
( PUNCT O
ART PROPN B-AC
) PUNCT O
became VERB O
available ADJ O
, PUNCT O
and CCONJ O
for ADP O
people NOUN O
living VERB O
in ADP O
affluent ADJ O
countries NOUN O
, PUNCT O
HIV PROPN O
/ SYM O
AIDS PROPN O
became VERB O
a DET O
chronic ADJ O
condition NOUN O
. PUNCT O

MS PROPN B-AC
, PUNCT O
mass NOUN B-LF
spectrometry NOUN I-LF
; PUNCT O
RNAi NOUN B-AC
, PUNCT O
RNA NOUN B-LF
interference NOUN I-LF
. PUNCT O

We PRON O
tested VERB O
the DET O
hypothesis NOUN O
that SCONJ O
the DET O
odds NOUN O
of ADP O
malaria NOUN O
infection NOUN O
are AUX O
lower ADJ O
in ADP O
modern ADJ O
, PUNCT O
improved ADJ O
housing NOUN O
compared VERB O
to ADP O
traditional ADJ O
housing NOUN O
in ADP O
sub PROPN B-LF
- PROPN I-LF
Saharan PROPN I-LF
Africa PROPN I-LF
( PUNCT O
SSA PROPN B-AC
) PUNCT O
. PUNCT O

Plasma NOUN O
creatine NOUN B-LF
kinase NOUN I-LF
( PUNCT O
CK PROPN B-AC
) PUNCT O
levels NOUN O
were AUX O
measured VERB O
on ADP O
test NOUN O
days NOUN O
and CCONJ O
after ADP O
three NUM O
weeks NOUN O
of ADP O
training NOUN O
as ADP O
a DET O
marker NOUN O
of ADP O
exercise NOUN O
- PUNCT O
induced VERB O
muscle NOUN O
damage NOUN O
. PUNCT O

The DET O
CI PROPN B-AC
is AUX O
derived VERB O
from ADP O
the DET O
concentration NOUN B-LF
curve NOUN I-LF
( PUNCT O
CC PROPN B-AC
) PUNCT O
which PRON O
plots VERB O
the DET O
cumulative ADJ O
percentage NOUN O
of ADP O
the DET O
health NOUN O
variable NOUN O
against ADP O
the DET O
cumulative ADJ O
percentage NOUN O
of ADP O
the DET O
population NOUN O
ranked VERB O
by ADP O
the DET O
living NOUN O
standards NOUN O
measure NOUN O
[ PUNCT O
12 NUM O
] PUNCT O
and CCONJ O
the DET O
CI PROPN B-AC
is AUX O
measured VERB O
as ADP O
twice DET O
the DET O
area NOUN O
between ADP O
the DET O
CC PROPN B-AC
and CCONJ O
the DET O
45 NUM O
degree NOUN O
line NOUN O
[ PUNCT O
12 NUM O
] PUNCT O
. PUNCT O

In ADP O
LD NOUN B-AC
conditions NOUN O
, PUNCT O
control NOUN O
flies NOUN O
expressing VERB O
membrane NOUN O
- ADJ O
tethered VERB O
μO NOUN O
- ADJ O
MrVIA PROPN O
in ADP O
the DET O
LNVs PROPN B-AC
exhibit VERB O
significantly ADV O
greater ADJ O
anti ADJ O
- ADJ O
PDF ADJ B-AC
immunofluorescence NOUN O
in ADP O
the DET O
sLNV NOUN B-AC
dorsomedial ADJ O
terminals NOUN O
at ADP O
zeitgeber NOUN B-LF
time NOUN I-LF
( PUNCT O
ZT)2 PROPN B-AC
and CCONJ O
ZT6 NOUN O
, PUNCT O
in ADP O
comparison NOUN O
to ADP O
the DET O
night NOUN O
at ADP O
ZT14 PROPN O
and CCONJ O
ZT18 NOUN O
( PUNCT O
p NOUN O
< SYM O
0.001 NUM O
; PUNCT O
Figure NOUN O
7C NUM O
) PUNCT O
. PUNCT O
In ADP O
contrast NOUN O
, PUNCT O
PDF ADJ B-AC
accumulation NOUN O
in ADP O
the DET O
sLNV NOUN B-AC
dorsomedial ADJ O
terminals NOUN O
of ADP O
experimental ADJ O
flies NOUN O
expressing VERB O
membrane NOUN O
- ADJ O
tethered VERB O
δ NOUN O
- ADJ O
ACTX NOUN O
- ADJ O
Hv1a PROPN O
in ADP O
the DET O
LNVs PROPN B-AC
cycles NOUN O
with ADP O
advanced ADJ O
phase NOUN O
, PUNCT O
peaking VERB O
late ADJ O
night NOUN O
, PUNCT O
rather ADV O
than ADP O
early ADV O
in ADP O
the DET O
morning NOUN O
, PUNCT O
with ADP O
peak ADJ O
anti ADJ O
- ADJ O
PDF ADJ B-AC
immunofluorescence NOUN O
at ADP O
around ADV O
ZT22 PROPN O
( PUNCT O
p NOUN O
< SYM O
0.001 NUM O
) PUNCT O
. PUNCT O

The DET B-LF
seismic ADJ I-LF
moment NOUN I-LF
M0 NOUN B-AC
was AUX O
obtained VERB O
using VERB O
Eq NOUN O
( PUNCT O
1 NUM O
) PUNCT O
, PUNCT O
and CCONJ O
then ADV O
, PUNCT O
the DET B-LF
moment NOUN I-LF
magnitude NOUN I-LF
MW NOUN O
was AUX O
calculated VERB O
based VERB O
on ADP O
the DET O
empirical ADJ O
relationship NOUN O
between ADP O
the DET B-LF
seismic ADJ I-LF
moment NOUN I-LF
M0 NOUN B-AC
and CCONJ O
the DET B-LF
moment NOUN I-LF
magnitude NOUN I-LF
MW NOUN O
[ SYM O
25,6 NUM O
] PUNCT O
: PUNCT O
Mw=23lgM0−6.07.(2 NUM B-AC
) PUNCT O

When SCONJ O
we PRON O
assessed VERB O
the DET O
presence NOUN O
of ADP O
inflammation NOUN O
in ADP O
the DET O
CNS PROPN B-AC
of ADP O
Nlrx1−/− NOUN O
2D2 NUM O
spEAE NOUN B-AC
mice NOUN O
, PUNCT O
we PRON O
found VERB O
that SCONJ O
the DET O
lack NOUN O
of ADP O
NLRX1 PROPN B-AC
did AUX O
not PART O
affect VERB O
the DET O
expression NOUN O
of ADP O
glial NOUN B-LF
fibrillary NOUN I-LF
acidic ADJ I-LF
protein NOUN I-LF
( PUNCT O
GFAP PROPN B-AC
) PUNCT O
, PUNCT O
ionized VERB B-LF
calcium NOUN I-LF
binding VERB I-LF
adaptor NOUN I-LF
molecule NOUN I-LF
1(Iba1 PROPN I-LF
) PUNCT O
, PUNCT O
and CCONJ O
myelin NOUN B-LF
basic ADJ I-LF
protein NOUN I-LF
( PUNCT O
MBP PROPN B-AC
) PUNCT O
in ADP O
the DET O
spinal ADJ O
cords NOUN O
of ADP O
healthy ADJ O
Nlrx1−/− NOUN O
2D2 NUM O
mice NOUN O
( PUNCT O
S1A PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

( PUNCT O
A NOUN O
, PUNCT O
D NOUN O
, PUNCT O
G NOUN O
, PUNCT O
J NOUN O
) PUNCT O
Neutrophil NOUN O
( PUNCT O
GR1 NOUN O
+ NOUN O
cells NOUN O
) PUNCT O
quantifications NOUN O
( PUNCT O
expressed VERB O
as ADP O
number NOUN O
of ADP O
cells NOUN O
per ADP O
ten NUM O
microscopic ADJ O
fields NOUN O
at ADP O
40X NUM O
) PUNCT O
in ADP O
the DET O
FI PROPN B-AC
( PUNCT O
A NOUN O
) PUNCT O
, PUNCT O
NTX PROPN B-AC
( PUNCT O
D NOUN O
) PUNCT O
, PUNCT O
CTX PROPN B-AC
( PUNCT O
G NOUN O
) PUNCT O
and CCONJ O
BaCl2 PROPN B-AC
( PUNCT O
J NOUN O
) PUNCT O
. PUNCT O
( PUNCT O
B NOUN O
, PUNCT O
E NOUN O
, PUNCT O
H NOUN O
, PUNCT O
K NOUN O
) PUNCT O
Macrophage NOUN O
( PUNCT O
F4/80 NOUN O
+ NOUN O
cells NOUN O
) PUNCT O
quantifications NOUN O
( PUNCT O
expressed VERB O
as ADP O
number NOUN O
of ADP O
cells NOUN O
per ADP O
field NOUN O
) PUNCT O
in ADP O
the DET O
FI PROPN B-AC
( PUNCT O
B NOUN O
) PUNCT O
, PUNCT O
NTX PROPN B-AC
( PUNCT O
E NOUN O
) PUNCT O
, PUNCT O
CTX PROPN B-AC
( PUNCT O
H NOUN O
) PUNCT O
and CCONJ O
BaCl2 PROPN B-AC
( PUNCT O
K NOUN O
) PUNCT O
. PUNCT O
Data NOUN O
are AUX O
represented VERB O
as ADP O
means±s.d NOUN O
. PUNCT O
* PUNCT O
p NOUN O
< SYM O
0.05 NUM O
; PUNCT O
* PUNCT O
* PUNCT O
p NOUN O
< SYM O
0.01 NUM O
; PUNCT O
* PUNCT O
* PUNCT O
* PUNCT O
p NOUN O
< SYM O
0.001 NUM O
; PUNCT O
no DET O
star NOUN O
, PUNCT O
statistically ADV O
non ADJ O
significant ADJ O
. PUNCT O
( PUNCT O
C PROPN O
, PUNCT O
F PROPN O
, PUNCT O
I PROPN O
, PUNCT O
L PROPN O
) PUNCT O
Luminex PROPN O
( PUNCT O
multiplex NOUN O
assay NOUN O
) PUNCT O
measuring VERB O
the DET O
levels NOUN O
of ADP O
cytokines NOUN O
in ADP O
pg NOUN O
/ SYM O
g NOUN O
of ADP O
muscle NOUN O
tissue NOUN O
, PUNCT O
18h NUM O
, PUNCT O
4 NUM O
days NOUN O
, PUNCT O
12 NUM O
days NOUN O
and CCONJ O
1 NUM O
month NOUN O
post NOUN O
- NOUN O
injury NOUN O
in ADP O
the DET O
freeze NOUN B-LF
injury NOUN I-LF
model NOUN O
( PUNCT O
C PROPN O
) PUNCT O
, PUNCT O
the DET O
NTX PROPN B-AC
( PUNCT O
F PROPN O
) PUNCT O
, PUNCT O
the DET O
CTX PROPN B-AC
( PUNCT O
I PROPN O
) PUNCT O
, PUNCT O
and CCONJ O
the DET O
BaCl2 PROPN B-AC
( PUNCT O
L PROPN O
) PUNCT O
. PUNCT O
Selected VERB O
cytokines NOUN O
( PUNCT O
IL6 PROPN O
; PUNCT O
IL10 PROPN O
; PUNCT O
MCP1 PROPN O
; PUNCT O
MIP1a PROPN O
and CCONJ O
MIG PROPN B-AC
) PUNCT O
are AUX O
displayed VERB O
for ADP O
each DET O
injury NOUN O
model NOUN O
. PUNCT O

The DET O
regulatory ADJ O
regions NOUN O
of ADP O
these DET O
inducible ADJ O
genes NOUN O
encode VERB O
the DET O
electrophile ADJ B-LF
- PUNCT I-LF
response NOUN I-LF
element NOUN I-LF
( PUNCT O
EpRE PROPN B-AC
) PUNCT O
. PUNCT O
This DET O
study NOUN O
tested VERB O
the DET O
EpRE PROPN B-AC
induction NOUN O
ability NOUN O
of ADP O
Maerua PROPN O
subcordata NOUN O
( PUNCT O
fruit NOUN O
, PUNCT O
leaf NOUN O
, PUNCT O
root NOUN O
, PUNCT O
seed NOUN O
) PUNCT O
methanol NOUN O
extracts NOUN O
and CCONJ O
selected VERB O
candidate NOUN O
constituents NOUN O
thereof ADV O
, PUNCT O
identified VERB O
by ADP O
liquid NOUN O
chromatography NOUN O
coupled VERB O
with ADP O
multistage ADJ O
mass NOUN O
spectroscopy NOUN O
, PUNCT O
employing VERB O
an DET O
EpRE PROPN B-AC
luciferase NOUN O
reporter NOUN O
gene NOUN O
assay NOUN O
using VERB O
hepa-1c1c7 NOUN O
mouse NOUN O
hepatoma NOUN O
cells NOUN O
. PUNCT O

We PRON O
identified VERB O
X NOUN O
- NOUN O
rays NOUN O
, PUNCT O
computerized VERB B-LF
tomography NOUN I-LF
( PUNCT O
CT PROPN B-AC
) PUNCT O
scans NOUN O
, PUNCT O
single ADJ B-LF
photon NOUN I-LF
emission NOUN I-LF
computerized VERB I-LF
tomography NOUN I-LF
( PUNCT O
SPECT PROPN B-AC
) PUNCT O
, PUNCT O
ultrasound NOUN O
, PUNCT O
magnetic ADJ B-LF
resonance NOUN I-LF
imaging NOUN I-LF
( PUNCT O
MRI PROPN B-AC
) PUNCT O
, PUNCT O
nuclear ADJ O
imaging NOUN O
and CCONJ O
endoscopy NOUN O
. PUNCT O

Abbreviation NOUN O
: PUNCT O
ISIS PROPN B-AC
, PUNCT O
Islamic PROPN B-LF
State PROPN I-LF
of ADP I-LF
Iraq PROPN I-LF
and CCONJ I-LF
Syria PROPN I-LF
. PUNCT O

Abbreviations NOUN O
: PUNCT O
LEA PROPN B-AC
, PUNCT O
lower ADJ B-LF
extremity NOUN I-LF
amputation NOUN I-LF
; PUNCT O
DFU PROPN B-AC
, PUNCT O
diabetic ADJ B-LF
foot NOUN I-LF
ulcer NOUN I-LF
. PUNCT O

Moreover ADV O
, PUNCT O
the DET O
importance NOUN O
of ADP O
the DET O
two NUM O
NUE NOUN B-AC
components NOUN O
, PUNCT O
NUpE PROPN B-AC
and CCONJ O
N PROPN B-LF
utilisation NOUN I-LF
efficiency NOUN I-LF
( PUNCT O
NUtE PROPN B-AC
) PUNCT O
are AUX O
variable ADJ O
, PUNCT O
mostly ADV O
depending VERB O
on ADP O
the DET O
amount NOUN O
of ADP O
the DET O
available ADJ O
N. NOUN O

The DET O
Autism PROPN B-LF
Diagnostic PROPN I-LF
Observation PROPN I-LF
Schedule PROPN I-LF
— PUNCT O
ADOS PROPN B-AC
[ X O
25 NUM O
] X O
was AUX O
used VERB O
to PART O
confirm VERB O
diagnoses NOUN O
. PUNCT O

Typical ADJ O
relative ADJ O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean NOUN I-LF
( PUNCT O
SEM PROPN B-AC
) PUNCT O
= PUNCT O
20 NUM O
% PUNCT O
. PUNCT O

A DET O
systematic ADJ O
search NOUN O
of ADP O
relevant ADJ O
articles NOUN O
in ADP O
Pubmed PROPN O
, PUNCT O
Wanfang PROPN O
, PUNCT O
Chinese PROPN B-LF
Scientific PROPN I-LF
Journals PROPN I-LF
Fulltext PROPN I-LF
Database PROPN I-LF
( PUNCT O
CQVIP PROPN B-AC
) PUNCT O
, PUNCT O
China PROPN B-LF
National PROPN I-LF
Knowledge PROPN I-LF
Infrastructure PROPN I-LF
( PUNCT O
CNKI PROPN B-AC
) PUNCT O
and CCONJ O
China PROPN B-LF
Biology PROPN I-LF
Medicine PROPN I-LF
disc NOUN I-LF
( PUNCT O
CBMdisc PROPN B-AC
) PUNCT O
was AUX O
undertaken VERB O
by ADP O
two NUM O
researchers NOUN O
on ADP O
September PROPN O
1,2017 NUM O
. PUNCT O

Disinfection NOUN B-LF
by NOUN I-LF
- PUNCT I-LF
products NOUN I-LF
( PUNCT O
DBPs PROPN B-AC
) PUNCT O
formation NOUN O
in ADP O
the DET O
treatment NOUN O
of ADP O
drinking NOUN O
water NOUN O
could AUX O
cause VERB O
long ADJ O
- PUNCT O
term NOUN O
adverse ADJ O
health NOUN O
effects NOUN O
on ADP O
humans NOUN O
. PUNCT O

Baltimore PROPN B-LF
Longitudinal PROPN I-LF
Study PROPN I-LF
of ADP I-LF
Aging PROPN I-LF
( PUNCT O
BLSA PROPN B-AC
) PUNCT O
data NOUN O
are AUX O
available ADJ O
to ADP O
researchers NOUN O
and CCONJ O
can AUX O
be AUX O
requested VERB O
at ADP O
https://www.blsa.nih.gov/researchers X O
. PUNCT O

The DET O
standard ADJ O
deviation NOUN O
of ADP O
WB PROPN B-AC
asymmetry NOUN O
, PUNCT O
which PRON O
was AUX O
9.83 NUM O
% NOUN O
was AUX O
considered VERB O
as ADP O
the DET O
Index PROPN B-LF
of ADP I-LF
Asymmetry PROPN I-LF
( PUNCT O
AI PROPN B-AC
) PUNCT O
[ PUNCT O
16 NUM O
] PUNCT O
. PUNCT O

HR NOUN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT O
95 NUM O
% NOUN O
CI NOUN O
, PUNCT O
95 NUM O
% NOUN O
confidence NOUN O
interval NOUN O
; PUNCT O
HDL PROPN B-AC
- PUNCT B-AC
C PROPN B-AC
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
cholesterol NOUN I-LF
; PUNCT O
LDL NOUN B-AC
- PUNCT B-AC
C PROPN B-AC
, PUNCT O
low ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
cholesterol NOUN I-LF
; PUNCT O
TC PROPN B-AC
, PUNCT O
total ADJ B-LF
cholesterol NOUN I-LF
; PUNCT O
TG NOUN B-AC
, PUNCT O
triglyceride NOUN B-LF
; PUNCT O
MPR PROPN B-AC
, PUNCT O
medication NOUN B-LF
possession NOUN I-LF
ratio NOUN I-LF
. PUNCT O

The DET O
surface NOUN B-LF
under ADP I-LF
the DET I-LF
cumulative ADJ I-LF
ranking NOUN I-LF
curve NOUN I-LF
( PUNCT O
SUCRA PROPN B-AC
) PUNCT O
represents VERB O
the DET O
ranking NOUN O
of ADP O
devices NOUN O
. PUNCT O

To PART O
study VERB O
how SCONJ O
zygotic ADJ O
transcriptional ADJ O
program NOUN O
is AUX O
regulated VERB O
, PUNCT O
we PRON O
first ADV O
generated VERB O
a DET O
2C::tandem NOUN B-LF
dimeric ADJ I-LF
Tomato PROPN I-LF
( PUNCT O
tdTomato PROPN B-AC
) PUNCT O
reporter NOUN O
ESC NOUN B-AC
line NOUN O
with ADP O
transgenic ADJ O
expression NOUN O
of ADP O
red ADJ O
fluorescence NOUN O
protein NOUN O
tdTomato PROPN B-AC
under ADP O
the DET O
control NOUN O
of ADP O
MERVL PROPN B-AC
5′UTR PROPN O
[ PUNCT O
5 NUM O
] PUNCT O
. PUNCT O

Spatial ADJ O
distribution NOUN O
of ADP O
young ADJ O
X NOUN O
- PUNCT O
linked VERB O
male NOUN O
- PUNCT O
biased VERB O
genes NOUN O
. PUNCT O
“ PUNCT O
Coordinate ADJ O
” PUNCT O
column NOUN O
shows VERB O
the DET O
position NOUN O
for ADP O
the DET O
middle ADJ O
point NOUN O
of ADP O
each DET O
gene NOUN O
. PUNCT O
“ PUNCT O
CT PROPN B-AC
” PUNCT O
marks VERB O
whether SCONJ O
a DET O
gene NOUN O
is AUX O
a DET O
Cancer PROPN B-LF
/ SYM I-LF
Testis PROPN I-LF
gene NOUN O
or CCONJ O
not PART O
according VERB O
to ADP O
the DET O
CTdatabase PROPN O
76 NUM O
. PUNCT O

Abbreviation NOUN O
: PUNCT O
CoA NOUN B-AC
, PUNCT O
coenzyme NOUN B-LF
A. NOUN I-LF

Furthermore ADV O
, PUNCT O
the DET O
Diagnostic PROPN B-LF
and CCONJ I-LF
Statistical PROPN I-LF
Manual PROPN I-LF
of ADP I-LF
Mental PROPN I-LF
Disorders-5 PROPN I-LF
( PUNCT O
DSM-5 PROPN B-AC
) PUNCT O
is AUX O
commonly ADV O
used VERB O
to PART O
diagnose VERB O
ADHD PROPN B-AC
categorically ADV O
. PUNCT O

By ADP O
employing VERB O
specialized ADJ O
cloning NOUN O
techniques NOUN O
and CCONJ O
vectors NOUN O
, PUNCT O
paired VERB O
- PUNCT O
end NOUN O
diTags NOUN O
( PUNCT O
PETs NOUN B-AC
) PUNCT O
from ADP O
ends NOUN O
of ADP O
transcripts NOUN O
and CCONJ O
this DET O
gene NOUN B-LF
identification NOUN I-LF
signature NOUN I-LF
( PUNCT O
GIS PROPN B-AC
) PUNCT O
can AUX O
be AUX O
sequenced VERB O
and CCONJ O
mapped VERB O
precisely ADV O
to ADP O
the DET O
genome NOUN O
[ PUNCT O
17 NUM O
] PUNCT O
. PUNCT O

VE PROPN B-AC
against ADP O
all DET O
other ADJ O
clinical ADJ O
end NOUN O
points NOUN O
was AUX O
estimated VERB O
as ADP O
a DET O
relative ADJ B-LF
risk NOUN I-LF
( PUNCT O
RR NOUN B-AC
) PUNCT O
reduction NOUN O
with ADP O
Fisher PROPN O
's PART O
exact ADJ O
p NOUN O
- PUNCT O
values NOUN O
. PUNCT O

HOMA PROPN B-AC
- PUNCT B-AC
IR PROPN B-AC
= PUNCT O
homeostasis NOUN B-LF
model NOUN I-LF
assessment NOUN I-LF
insulin NOUN I-LF
resistance NOUN I-LF

Accumulating VERB O
evidence NOUN O
has AUX O
shown VERB O
that SCONJ O
exposure NOUN O
to ADP O
environmental ADJ B-LF
tobacco NOUN I-LF
smoke NOUN I-LF
( PUNCT O
ETS PROPN B-AC
) PUNCT O
is AUX O
associated VERB O
with ADP O
cardiovascular ADJ B-LF
diseases NOUN I-LF
( PUNCT O
CVDs NOUN B-AC
) PUNCT O
However ADV O
, PUNCT O
few ADJ O
studies NOUN O
have AUX O
assessed VERB O
both DET O
exposure NOUN O
to ADP O
ETS PROPN B-AC
and CCONJ O
high ADV O
- PUNCT O
perceived ADJ O
work NOUN O
stress NOUN O
on ADP O
hyperlipidemia NOUN O
. PUNCT O

DWI NOUN B-AC
= PUNCT O
diffusion NOUN B-LF
- PUNCT I-LF
weighted VERB I-LF
imaging NOUN I-LF
, PUNCT O
PPV NOUN O
= PUNCT O
positive ADJ O
predictive ADJ O
value NOUN O
, PUNCT O
NPV NOUN O
= PUNCT O
negative ADJ O
predictive ADJ O
value NOUN O

Lastly ADV O
, PUNCT O
components NOUN O
of ADP O
the DET O
APC PROPN B-AC
, PUNCT O
a DET O
major ADJ O
multi ADJ O
- ADJ O
subunit ADJ O
regulator NOUN O
of ADP O
the DET O
cell NOUN O
cycle NOUN O
, PUNCT O
are AUX O
lost VERB O
in ADP O
both DET O
lineages NOUN O
( PUNCT O
i.e. X O
, PUNCT O
CDC26 PROPN O
and CCONJ O
Meiotic PROPN B-LF
Nuclear PROPN I-LF
Divisions PROPN I-LF
2 NUM I-LF
[ PUNCT O
MND2 PROPN B-AC
] PUNCT O
) PUNCT O
or CCONJ O
just ADV O
the DET O
FEL PROPN B-AC
( PUNCT O
i.e. X O
, PUNCT O
APC2 PROPN O
, PUNCT O
APC4 PROPN O
, PUNCT O
APC5 PROPN O
, PUNCT O
and CCONJ O
Spore PROPN B-LF
Wall PROPN I-LF
Maturation PROPN I-LF
1 NUM I-LF
[ PUNCT O
SWM1 PROPN B-AC
] PUNCT O
) PUNCT O
. PUNCT O

Here ADV O
, PUNCT O
we PRON O
used VERB O
a DET O
rat NOUN O
model NOUN O
of ADP O
ischemic ADJ B-LF
- PUNCT I-LF
reperfusion NOUN I-LF
nerve NOUN I-LF
injury NOUN I-LF
( PUNCT O
IRI PROPN B-AC
) PUNCT O
to PART O
investigate VERB O
possible ADJ O
effects NOUN O
of ADP O
hepatocyte NOUN B-LF
growth NOUN I-LF
factor NOUN I-LF
( PUNCT O
HGF PROPN B-AC
) PUNCT O
against ADP O
ischemic ADJ O
neuropathy NOUN O
. PUNCT O

CeMM PROPN B-AC
, PUNCT O
C. PROPN O
elegans PROPN O
maintenance NOUN O
medium NOUN O
; PUNCT O
FFA PROPN O
, PUNCT O
linolenate NOUN O
; PUNCT O
hlh-30 NOUN B-AC
, PUNCT O
basic ADJ B-LF
helix NOUN I-LF
– PUNCT I-LF
loop NOUN I-LF
– PUNCT I-LF
helix NOUN I-LF
transcription NOUN I-LF
factor NOUN I-LF
30 NUM I-LF
; PUNCT O
hlh-30(lf NOUN B-AC
) PUNCT O
, PUNCT O
loss NOUN O
- PUNCT O
of ADP O
- PUNCT O
function NOUN O
tm1978 NOUN B-AC
mutation NOUN O
hlh-30 NOUN B-AC
; PUNCT O
LPC PROPN B-AC
, PUNCT O
lyso NOUN B-LF
phosphatidyl NOUN I-LF
choline NOUN I-LF
; PUNCT O
SEM NOUN B-AC
, PUNCT O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean NOUN I-LF
; PUNCT O
TCA PROPN B-AC
, PUNCT O
tricarboxylic ADJ B-LF
acid NOUN I-LF
cycle NOUN I-LF
; PUNCT O
α NOUN B-AC
- PUNCT B-AC
FFA PROPN B-AC
, PUNCT O
α NOUN B-LF
- PUNCT I-LF
linolenate NOUN I-LF
; PUNCT O
γ NOUN B-AC
- PUNCT B-AC
FFA PROPN B-AC
, PUNCT O
γ NOUN B-LF
- PUNCT I-LF
linolenate NOUN I-LF
. PUNCT O

CKD PROPN B-AC
, PUNCT O
chronic ADJ B-LF
kidney NOUN I-LF
disease NOUN I-LF
; PUNCT O
creat NOUN B-AC
- PUNCT B-AC
cys NOUN B-AC
, PUNCT O
creatinine NOUN B-LF
and CCONJ I-LF
cystatin NOUN I-LF
C NOUN I-LF
; PUNCT O
cys NOUN B-AC
, PUNCT O
cystatin NOUN B-LF
C NOUN I-LF
; PUNCT O
DM NOUN O
, PUNCT O
diabetes NOUN O
mellitus NOUN O
; PUNCT O
eGFR NOUN B-AC
, PUNCT O
estimated VERB B-LF
glomerular ADJ I-LF
filtration NOUN I-LF
rate NOUN I-LF
; PUNCT O
GFR PROPN B-AC
, PUNCT O
glomerular ADJ B-LF
filtration NOUN I-LF
rate NOUN I-LF
; PUNCT O
GP PROPN B-AC
, PUNCT O
general ADJ B-LF
practitioner NOUN I-LF
; PUNCT O
HT NOUN O
, PUNCT O
hypertension NOUN O
; PUNCT O
NICE PROPN B-AC
, PUNCT O
National PROPN B-LF
Institute PROPN I-LF
for ADP I-LF
Health PROPN I-LF
and CCONJ I-LF
Care PROPN I-LF
Excellence PROPN I-LF
; PUNCT O
uACR NOUN B-AC
, PUNCT O
urine NOUN B-LF
albumin NOUN I-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
creatinine NOUN I-LF
ratio NOUN I-LF
. PUNCT O

Consistently ADV O
, PUNCT O
Nearest PROPN B-LF
Neighbor PROPN I-LF
Distance PROPN I-LF
( PUNCT O
NND PROPN B-AC
) PUNCT O
analysis NOUN O
( PUNCT O
S2 PROPN O
Table PROPN O
) PUNCT O
of ADP O
E12 PROPN O
- PUNCT O
P30 NOUN O
HetCs NOUN B-AC
showed VERB O
a DET O
significant ADJ O
degree NOUN O
of ADP O
clustering NOUN O
in ADP O
both CCONJ O
double ADJ O
and CCONJ O
triple ADJ O
clones NOUN O
, PUNCT O
as SCONJ O
disclosed VERB O
by ADP O
their PRON O
different ADJ O
distributions NOUN O
as SCONJ O
compared VERB O
to ADP O
random ADJ O
distributions NOUN O
( PUNCT O
Fig PROPN O
5A NUM O
) PUNCT O
. PUNCT O
Interestingly ADV O
, PUNCT O
the DET O
cortical ADJ O
component NOUN O
( PUNCT O
BG PROPN B-AC
and CCONJ O
GLAs PROPN B-AC
) PUNCT O
was AUX O
comparable ADJ O
in ADP O
triple ADJ O
and CCONJ O
double ADJ O
clones NOUN O
, PUNCT O
suggesting VERB O
similar ADJ O
modalities NOUN O
of ADP O
cortical ADJ O
colonization NOUN O
and CCONJ O
reflecting VERB O
a DET O
separate ADJ O
allocation NOUN O
of ADP O
WMAs NOUN B-AC
. PUNCT O

ALD PROPN B-AC
, PUNCT O
alcoholic ADJ B-LF
liver NOUN I-LF
disease NOUN I-LF
; PUNCT O
HBV PROPN B-AC
, PUNCT O
hepatitis NOUN B-LF
B NOUN I-LF
virus NOUN I-LF
; PUNCT O
HCC PROPN B-AC
, PUNCT O
hepatocellular ADJ B-LF
carcinoma NOUN I-LF
; PUNCT O
HCV PROPN B-AC
, PUNCT O
hepatitis NOUN B-LF
C NOUN I-LF
virus NOUN I-LF
; PUNCT O
NAFLD PROPN B-AC
, PUNCT O
non ADJ O
- ADJ O
alcoholic ADJ O
fatty ADJ O
liver NOUN O
disease NOUN O
. PUNCT O

AIP PROPN B-AC
Atherogenic ADJ B-LF
index NOUN I-LF
of ADP I-LF
plasma NOUN I-LF
, PUNCT O
β NOUN B-AC
- PUNCT B-AC
TM NOUN B-AC
thalassemia NOUN O
major ADJ O
, PUNCT O
hcy NOUN O
homocysteine NOUN O
, PUNCT O
HDL NOUN B-AC
- PUNCT B-AC
C NOUN B-AC
high ADJ B-LF
density NOUN I-LF
lipoprotein NOUN I-LF
- PUNCT I-LF
cholesterol NOUN I-LF
, PUNCT O
LDL NOUN B-AC
- PUNCT B-AC
C NOUN B-AC
low ADJ B-LF
density NOUN I-LF
lipoprotein NOUN I-LF
- PUNCT I-LF
cholesterol NOUN I-LF
, PUNCT O
MDA PROPN B-AC
malondialdehyde NOUN B-LF
, PUNCT O
oxLDL NOUN O
oxidized VERB O
low ADJ O
density NOUN O
lipoprotein NOUN O
, PUNCT O
TAC PROPN B-AC
total ADJ B-LF
antioxidant ADJ I-LF
capacity NOUN I-LF
, PUNCT O
TC PROPN B-AC
total ADJ B-LF
cholesterol NOUN I-LF
, PUNCT O
TG NOUN B-AC
triglycerides NOUN B-LF
, PUNCT O
total ADJ O
NOx PROPN O
total ADJ O
nitric NOUN O
oxide NOUN O
. PUNCT O

Sexual ADJ O
identity NOUN O
is AUX O
governed VERB O
by ADP O
sex NOUN O
chromosomes NOUN O
in ADP O
plants NOUN O
and CCONJ O
animals NOUN O
, PUNCT O
and CCONJ O
by ADP O
mating NOUN B-LF
type NOUN I-LF
( PUNCT O
MAT PROPN B-AC
) PUNCT O
loci NOUN O
in ADP O
fungi NOUN O
. PUNCT O

CDS PROPN B-AC
, PUNCT O
coding VERB B-LF
DNA NOUN I-LF
sequence NOUN I-LF
; PUNCT O
RPKM PROPN B-AC
, PUNCT O
reads NOUN B-LF
per ADP I-LF
kilobase NOUN I-LF
of ADP I-LF
transcript NOUN I-LF
per ADP I-LF
million NUM I-LF
mapped VERB I-LF
reads NOUN I-LF
; PUNCT O
TE NOUN B-AC
, PUNCT O
translational ADJ B-LF
efficiency NOUN I-LF
; PUNCT O
UTR NOUN B-AC
, PUNCT O
untranslated VERB B-LF
region NOUN I-LF
. PUNCT O

Mass ADJ O
spectrometric ADJ O
analysis NOUN O
of ADP O
TlpD PROPN B-AC
was AUX O
performed VERB O
as ADP O
a DET O
service NOUN O
by ADP O
Dr. PROPN O
Larry PROPN O
David PROPN O
at ADP O
Oregon PROPN B-LF
Health PROPN I-LF
and CCONJ I-LF
Science PROPN I-LF
University PROPN I-LF
’s PART O
( PUNCT O
OHSU PROPN B-AC
) PUNCT O
Proteomics PROPN O
Shared PROPN O
Resource PROPN O
Facility PROPN O
. PUNCT O

The DET O
following ADJ O
clinical ADJ O
features NOUN O
and CCONJ O
biochemistry NOUN O
were AUX O
collected VERB O
for ADP O
analysis NOUN O
: PUNCT O
age NOUN O
, PUNCT O
sex NOUN O
, PUNCT O
diabetes NOUN B-LF
mellitus NOUN I-LF
( PUNCT O
DM PROPN B-AC
) PUNCT O
status NOUN O
, PUNCT O
Barcelona PROPN B-LF
Clinic PROPN I-LF
Liver PROPN I-LF
Cancer PROPN I-LF
( PUNCT O
BCLC PROPN B-AC
) PUNCT O
stage NOUN O
, PUNCT O
Child PROPN O
- PUNCT O
Pugh PROPN O
score NOUN O
, PUNCT O
serum ADJ O
AFP NOUN B-AC
, PUNCT O
alanine NOUN B-LF
aminotransferase NOUN I-LF
( PUNCT O
ALT PROPN B-AC
) PUNCT O
, PUNCT O
aspartate NOUN B-LF
aminotransferase NOUN I-LF
( PUNCT O
AST PROPN B-AC
) PUNCT O
, PUNCT O
creatinine NOUN O
, PUNCT O
albumin NOUN O
, PUNCT O
total ADJ O
bilirubin NOUN O
levels NOUN O
, PUNCT O
platelet NOUN O
count NOUN O
, PUNCT O
and CCONJ O
prothrombin NOUN O
time NOUN O
( PUNCT O
measured VERB O
by ADP O
international ADJ B-LF
normalized ADJ I-LF
ratio NOUN I-LF
[ PUNCT O
INR PROPN B-AC
] PUNCT O
) PUNCT O
. PUNCT O

Five NUM O
of ADP O
these DET O
herds NOUN O
, PUNCT O
namely ADV O
Castle PROPN O
- ADJ O
Carbondale PROPN O
( PUNCT O
CC PROPN B-AC
) PUNCT O
, PUNCT O
Beauvais PROPN O
Lake PROPN O
( PUNCT O
BL PROPN B-AC
) PUNCT O
, PUNCT O
Livingstone PROPN O
( PUNCT O
L PROPN O
) PUNCT O
, PUNCT O
Whaleback PROPN O
( PUNCT O
WH PROPN B-AC
) PUNCT O
and CCONJ O
Porcupine PROPN B-LF
Hills PROPN I-LF
( PUNCT O
PH PROPN B-AC
) PUNCT O
, PUNCT O
were AUX O
in ADP O
areas NOUN O
of ADP O
high ADJ O
cattle NOUN O
density NOUN O
( PUNCT O
‘ PUNCT O
exposed ADJ O
’ PUNCT O
herds NOUN O
) PUNCT O
, PUNCT O
while SCONJ O
the DET O
other ADJ O
five NUM O
, PUNCT O
namely ADV O
Jasper PROPN B-LF
National PROPN I-LF
Park PROPN I-LF
( PUNCT O
JNP PROPN B-AC
) PUNCT O
, PUNCT O
Ya PROPN B-LF
Ha PROPN I-LF
Tinda PROPN I-LF
( PUNCT O
YHT PROPN B-AC
) PUNCT O
, PUNCT O
Banff PROPN B-LF
National PROPN I-LF
Park PROPN I-LF
( PUNCT O
BNP PROPN B-AC
) PUNCT O
, PUNCT O
Crowsnest PROPN B-LF
Pass PROPN I-LF
( PUNCT O
CP PROPN B-AC
) PUNCT O
, PUNCT O
Waterton PROPN B-LF
National PROPN I-LF
Park PROPN I-LF
( PUNCT O
WNP PROPN B-AC
) PUNCT O
, PUNCT O
had VERB O
no PRON O
or CCONJ O
limited ADJ O
contact NOUN O
with ADP O
cattle NOUN O
( PUNCT O
‘ PUNCT O
non ADJ O
- ADJ O
exposed ADJ O
herds NOUN O
) PUNCT O
( PUNCT O
Table PROPN O
1 NUM O
) PUNCT O
. PUNCT O

Undernutrition NOUN O
in ADP O
children NOUN O
remains VERB O
a DET O
major ADJ O
global ADJ O
health NOUN O
issue NOUN O
and CCONJ O
the DET O
prevalence NOUN O
of ADP O
undernutrition NOUN O
in ADP O
children NOUN O
under ADP O
age NOUN O
five NUM O
in ADP O
the DET O
Democratic PROPN B-LF
Republic PROPN I-LF
of ADP I-LF
the DET I-LF
Congo PROPN I-LF
( PUNCT O
DRC PROPN B-AC
) PUNCT O
is AUX O
among ADP O
the DET O
highest ADJ O
in ADP O
the DET O
world NOUN O
. PUNCT O

The DET O
ts NOUN B-AC
: NOUN O
tv NOUN B-AC
ratio NOUN O
is AUX O
not PART O
significantly ADV O
different ADJ O
from ADP O
1:2 NUM O
, PUNCT O
as ADV O
would AUX O
be AUX O
expected VERB O
under ADP O
a DET O
uniform ADJ O
mutation NOUN O
rate NOUN O
( PUNCT O
because SCONJ O
there PRON O
are VERB O
twice DET O
as ADV O
many ADJ O
possible ADJ O
transversions NOUN B-LF
) PUNCT O
. PUNCT O

All DET O
proteins NOUN O
in ADP O
Escherichia PROPN O
coli PROPN O
were AUX O
expressed VERB O
in ADP O
BL21 PROPN O
- NOUN O
CodonPlus PROPN O
- NOUN O
RP PROPN O
competent ADJ O
cells NOUN O
strain NOUN O
by ADP O
adding VERB O
1 NUM O
mM NOUN O
of ADP O
Isopropyl-1 NOUN B-LF
- NOUN I-LF
thio NOUN I-LF
- NOUN I-LF
β NOUN I-LF
- NOUN I-LF
D NOUN I-LF
- NOUN I-LF
galactopyranoside NOUN I-LF
( PUNCT O
IPTG PROPN B-AC
) PUNCT O
and CCONJ O
incubating VERB O
the DET O
culture NOUN O
at ADP O
200 NUM O
rpm NOUN O
, PUNCT O
18 NUM O
° NOUN O
C NOUN O
for ADP O
6 NUM O
hours NOUN O
. PUNCT O

Underlying VERB O
data NOUN O
are AUX O
provided VERB O
in ADP O
S1 PROPN O
Data PROPN O
. PUNCT O
αSMA PROPN B-AC
; PUNCT O
α NOUN O
smooth ADJ O
muscle NOUN O
actin NOUN O
; PUNCT O
DAPI PROPN B-AC
, PUNCT O
4′,6 NUM B-LF
- PUNCT I-LF
diamidino-2 NOUN I-LF
- PUNCT I-LF
phenylindole NOUN I-LF
; PUNCT O
n.s X O
. PUNCT O
, PUNCT O
not PART O
significant ADJ O
; PUNCT O
TGFβ1 NOUN B-AC
, PUNCT O
transforming VERB B-LF
growth NOUN I-LF
factor NOUN I-LF
β1 NOUN I-LF
. PUNCT O

Abbreviations NOUN O
: PUNCT O
CI PROPN B-AC
, PUNCT O
Confidence NOUN B-LF
Interval NOUN I-LF
; PUNCT O
ED PROPN B-AC
, PUNCT O
Emergency PROPN B-LF
Department PROPN I-LF
; PUNCT O
MCC PROPN O
, PUNCT O
Mean PROPN O
Cumulative ADJ O
Count NOUN O
. PUNCT O

Examples NOUN O
of ADP O
the DET O
latter ADJ O
case NOUN O
are AUX O
so ADV O
- PUNCT O
called VERB O
“ PUNCT O
survivors NOUN O
” PUNCT O
of ADP O
telomerase NOUN O
deletion NOUN O
in ADP O
Saccharomyces PROPN O
cerevisiae NOUN O
and CCONJ O
alternative ADJ B-LF
lengthening NOUN I-LF
of ADP I-LF
telomeres NOUN I-LF
( PUNCT O
ALT PROPN B-AC
) PUNCT O
cells NOUN O
in ADP O
mammals NOUN O
[ PUNCT O
3,4 NUM O
] PUNCT O
. PUNCT O

AFC PROPN B-AC
, PUNCT O
allele NOUN B-LF
frequency NOUN I-LF
change NOUN I-LF
; PUNCT O
ASFC PROPN O
, PUNCT O
allele NOUN O
- PUNCT O
specific ADJ O
frequency NOUN O
change NOUN O
; PUNCT O
HSD PROPN B-AC
, PUNCT O
honest ADJ B-LF
significant ADJ I-LF
difference NOUN I-LF
; PUNCT O
RFS PROPN B-AC
, PUNCT O
replicate NOUN B-LF
frequency NOUN I-LF
spectrum NOUN I-LF
; PUNCT O
QT PROPN B-AC
, PUNCT O
quantitative ADJ O
trait NOUN O
. PUNCT O

More ADJ O
than ADP O
29 NUM O
million NUM O
that PRON O
is AUX O
an DET O
estimated VERB O
5 NUM O
% PUNCT O
, PUNCT O
under NOUN O
- PUNCT O
five NUM O
children NOUN O
suffer VERB O
from ADP O
severe ADJ B-LF
acute ADJ I-LF
malnutrition NOUN I-LF
( PUNCT O
SAM PROPN B-AC
) PUNCT O
globally ADV O
, PUNCT O
with ADP O
a DET O
nine NUM O
times NOUN O
higher ADJ O
risk NOUN O
of ADP O
mortality NOUN O
than ADP O
that PRON O
of ADP O
well ADV O
- PUNCT O
nourished ADJ O
children NOUN O
. PUNCT O

We PRON O
employed VERB O
three NUM O
haplotype NOUN O
partitioning NOUN O
methods NOUN O
which PRON O
are AUX O
confidence NOUN B-LF
interval NOUN I-LF
test NOUN I-LF
( PUNCT O
CIT PROPN B-AC
) PUNCT O
, PUNCT O
four NUM B-LF
gamete NOUN I-LF
test NOUN I-LF
( PUNCT O
FGT PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
solid ADJ B-LF
spine NOUN I-LF
of ADP I-LF
linkage NOUN I-LF
disequilibrium NOUN I-LF
( PUNCT O
SSLD PROPN B-AC
) PUNCT O
. PUNCT O
P NOUN O
- NOUN O
values NOUN O
after ADP O
stringent ADJ O
Bonferroni PROPN O
correction NOUN O
for ADP O
multiple ADJ O
testing NOUN O
were AUX O
measured VERB O
to PART O
assess VERB O
the DET O
strength NOUN O
of ADP O
association NOUN O
between ADP O
the DET O
genetic ADJ O
variants NOUN O
and CCONJ O
RA PROPN B-AC
susceptibility NOUN O
. PUNCT O

Colorectal ADJ B-LF
cancer NOUN I-LF
( PUNCT O
CRC PROPN B-AC
) PUNCT O
is AUX O
the DET O
third ADV O
most ADV O
common ADJ O
cancer NOUN O
and CCONJ O
the DET O
fourth ADV O
leading VERB O
cause NOUN O
of ADP O
cancer NOUN O
- PUNCT O
related VERB O
mortality NOUN O
worldwide ADV O
[ PUNCT O
1 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
locally ADV B-LF
advanced VERB I-LF
rectal ADJ I-LF
cancer NOUN I-LF
( PUNCT O
LARC PROPN B-AC
) PUNCT O
constitutes VERB O
up ADP O
to PART O
15 NUM O
% NOUN O
of ADP O
all DET O
CRC PROPN B-AC
cases NOUN O
[ PUNCT O
2 NUM O
] PUNCT O
. PUNCT O

NASH PROPN B-AC
= PUNCT O
Nonalcoholic ADJ B-LF
Steatohepatitis NOUN I-LF
, PUNCT O
NFS PROPN B-AC
= PUNCT O
NAFLD PROPN B-LF
Fibrosis PROPN I-LF
Score PROPN I-LF
, PUNCT O
VCTE PROPN B-AC
= PUNCT O
Vibration PROPN B-LF
Controlled PROPN I-LF
Transient PROPN I-LF
Elastography PROPN I-LF

Add VERB O
- PUNCT O
on ADP O
therapy NOUN O
refers VERB O
to ADP O
LABA PROPN B-AC
, PUNCT O
LTRA PROPN B-AC
, PUNCT O
theophylline NOUN O
, PUNCT O
or CCONJ O
LAMA PROPN B-AC
. PUNCT O
ICS PROPN B-AC
, PUNCT O
inhaled VERB B-LF
corticosteroid NOUN I-LF
; PUNCT O
LABA PROPN B-AC
, PUNCT O
long ADV O
- PUNCT O
acting VERB O
β2 NOUN O
- PUNCT O
agonist NOUN O
; PUNCT O
LAMA PROPN B-AC
, PUNCT O
long ADV B-LF
- PUNCT I-LF
acting VERB I-LF
muscarinic NOUN I-LF
antagonist NOUN I-LF
; PUNCT O
LTRA PROPN B-AC
, PUNCT O
leukotriene NOUN B-LF
receptor NOUN I-LF
antagonist NOUN I-LF
. PUNCT O

Seven NUM O
serum NOUN O
groups NOUN O
were AUX O
assayed VERB O
for ADP O
growth NOUN O
by ADP O
72 NUM O
- PUNCT O
hr NOUN O
incubation NOUN O
and CCONJ O
SYBR PROPN O
assay NOUN O
as SCONJ O
previously ADV O
described VERB O
: PUNCT O
10 NUM O
% NOUN O
SHS NOUN B-AC
, PUNCT O
10 NUM O
% NOUN O
SHS NOUN B-AC
+ SYM O
DHAPPQ PROPN B-AC
( PUNCT O
as SCONJ O
previously ADV O
described VERB O
) PUNCT O
, PUNCT O
10 NUM O
% NOUN O
SHS NOUN B-AC
+ SYM O
10 NUM O
% NOUN O
water NOUN O
, PUNCT O
20 NUM O
% NOUN O
SHS NOUN B-AC
, PUNCT O
10 NUM O
% NOUN O
SHS NOUN B-AC
+ SYM O
10 NUM O
% NOUN O
Kenyan ADJ O
Adult NOUN O
serum NOUN O
, PUNCT O
10 NUM O
% NOUN O
SHS NOUN B-AC
+ SYM O
10 NUM O
% NOUN O
Kenyan ADJ O
Pediatric ADJ O
serum NOUN O
, PUNCT O
and CCONJ O
10 NUM O
% NOUN O
SHS NOUN B-AC
+ SYM O
10 NUM O
% NOUN O
US PROPN B-LF
Adult NOUN I-LF
serum NOUN O
. PUNCT O

ERK5 PROPN O
, PUNCT O
extracellular ADJ O
signal NOUN O
– PUNCT O
regulated VERB O
kinase PROPN O
5 NUM O
; PUNCT O
ERM PROPN B-AC
, PUNCT O
Ezrin PROPN O
( PUNCT O
Thr567)/Radixin PROPN O
( PUNCT O
Thr564)/Moesin PROPN O
( PUNCT O
Thr558 NOUN O
) PUNCT O
; PUNCT O
HR PROPN O
, PUNCT O
hazard NOUN O
ratio NOUN O
; PUNCT O
IB PROPN B-AC
, PUNCT O
immunoblot NOUN B-LF
; PUNCT O
KO PROPN B-AC
, PUNCT O
knockout NOUN B-LF
; PUNCT O
NS PROPN O
, PUNCT O
not PART O
significant ADJ O
; PUNCT O
NSG PROPN B-AC
, PUNCT O
NOD NOUN B-LF
scid NOUN I-LF
gamma NOUN I-LF
; PUNCT O
OE PROPN B-AC
, PUNCT O
overexpressing NOUN B-LF
; PUNCT O
PDCD10 PROPN B-AC
, PUNCT O
programmed VERB B-LF
cell NOUN I-LF
death NOUN I-LF
protein NOUN I-LF
10 NUM I-LF
; PUNCT O
p NOUN O
- PUNCT O
ERM PROPN B-AC
, PUNCT O
phosphorylation NOUN O
of ADP O
ERM PROPN B-AC
; PUNCT O
RhoA PROPN B-AC
, PUNCT O
Ras PROPN B-LF
homolog NOUN I-LF
family NOUN I-LF
member NOUN I-LF
A PROPN I-LF
; PUNCT O
ROCK1 PROPN O
, PUNCT O
Rho PROPN O
- PUNCT O
associated VERB O
coiled NOUN O
- PUNCT O
coil NOUN O
kinase PROPN O
1 NUM O
; PUNCT O
shRNA PROPN B-AC
, PUNCT O
short ADJ B-LF
hairpin NOUN I-LF
RNA NOUN I-LF
; PUNCT O
TRIM59 PROPN O
, PUNCT O
tripartite NOUN O
motif NOUN O
59 NUM O
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

We PRON O
propose VERB O
Historical PROPN B-LF
Information PROPN I-LF
for ADP I-LF
Class PROPN I-LF
Stability PROPN I-LF
Prediction PROPN I-LF
( PUNCT O
HICSP PROPN B-AC
) PUNCT O
, PUNCT O
an DET O
approach NOUN O
to PART O
exploit VERB O
change NOUN O
history NOUN O
information NOUN O
to PART O
predict VERB O
the DET O
instable ADJ O
classes NOUN O
based VERB O
on ADP O
its PRON O
correlation NOUN O
with ADP O
change NOUN O
propagation NOUN O
factors NOUN O
. PUNCT O

We PRON O
determined VERB O
the DET O
NSAIDs PROPN B-AC
recommended VERB O
by ADP O
the DET O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT O
WHO PROPN B-AC
) PUNCT O
in ADP O
its PRON O
Model PROPN O
List PROPN O
of ADP O
Essential PROPN O
Medicines PROPN O
[ PUNCT O
15 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
by ADP O
individual ADJ O
countries NOUN O
with ADP O
published VERB O
national ADJ O
EMLs NOUN B-AC
[ PUNCT O
16 NUM O
] PUNCT O
. PUNCT O

For ADP O
example NOUN O
, PUNCT O
other ADJ O
hypertensive ADJ O
animal NOUN O
models NOUN O
such ADJ O
as ADP O
endothelial ADJ O
NOS PROPN B-AC
( PUNCT O
eNOS PROPN B-AC
) PUNCT O
knock NOUN B-LF
- PUNCT I-LF
out NOUN I-LF
( PUNCT O
KO PROPN B-AC
) PUNCT O
mice NOUN O
do AUX O
not PART O
have VERB O
cardiac ADJ O
hypertrophy NOUN O
[ PUNCT O
38 NUM O
, PUNCT O
39 NUM O
] PUNCT O
. PUNCT O

To PART O
assess VERB O
our PRON O
proposed VERB O
new ADJ O
method NOUN O
, PUNCT O
we PRON O
performed VERB O
simulation NOUN O
analyses NOUN O
to PART O
compare VERB O
the DET O
relative ADJ O
performances NOUN O
of ADP O
( PUNCT O
1 X O
) PUNCT O
conventional ADJ O
haplotype NOUN O
- PUNCT O
based VERB O
analysis NOUN O
using VERB O
original ADJ O
haplotype NOUN O
, PUNCT O
( PUNCT O
2 X O
) PUNCT O
single ADJ O
- PUNCT O
locus NOUN O
allele NOUN O
- PUNCT O
based VERB O
analysis NOUN O
, PUNCT O
( PUNCT O
3 X O
) PUNCT O
original ADJ O
haplotype NOUN O
cladistic ADJ O
analysis NOUN O
( PUNCT O
CLADHC PROPN B-AC
) PUNCT O
by ADP O
Durrant PROPN O
et X O
al NOUN O
. PUNCT O
, PUNCT O
and CCONJ O
( PUNCT O
4 X O
) PUNCT O
our PRON O
weighted VERB O
haplotype NOUN B-LF
cladistic ADJ I-LF
analysis NOUN I-LF
method NOUN I-LF
, PUNCT O
under ADP O
different ADJ O
scenarios NOUN O
. PUNCT O

In ADP O
S. PROPN O
album NOUN O
plants NOUN O
, PUNCT O
santalenes NOUN O
and CCONJ O
bergamotene NOUN O
can AUX O
be AUX O
generated VERB O
from ADP O
farnesyl NOUN B-LF
diphosphate NOUN I-LF
( PUNCT O
FPP PROPN B-AC
) PUNCT O
in ADP O
the DET O
MVA PROPN B-AC
pathway NOUN O
via ADP O
the DET O
activity NOUN O
of ADP O
santalene NOUN B-LF
synthase NOUN I-LF
( PUNCT O
SaSSy PROPN B-AC
) PUNCT O
[ X O
23,24 NUM O
] PUNCT O
. PUNCT O

Compared VERB O
to ADP O
a DET O
cohort NOUN O
of ADP O
The PROPN B-LF
Cancer PROPN I-LF
Genome PROPN I-LF
Atlas PROPN I-LF
( PUNCT O
TCGA PROPN B-AC
) PUNCT O
patients NOUN O
with ADP O
HER2 PROPN O
- PUNCT O
positive ADJ O
non ADJ O
- PUNCT O
IBC PROPN B-AC
, PUNCT O
HER2 PROPN O
- PUNCT O
positive ADJ O
IBC PROPN B-AC
patients NOUN O
had VERB O
significantly ADV O
higher ADJ O
mutational ADJ O
and CCONJ O
neoantigenic ADJ O
burden NOUN O
, PUNCT O
more ADV O
frequent ADJ O
gain NOUN O
- PUNCT O
of ADP O
- PUNCT O
function NOUN O
TP53 NOUN O
mutations NOUN O
and CCONJ O
a DET O
recurrent ADJ O
11q13.5 NUM O
amplification NOUN O
overlapping VERB O
PAK1 NOUN O
. PUNCT O
Planned ADJ O
exploratory ADJ O
analysis NOUN O
revealed VERB O
that SCONJ O
trastuzumab NOUN O
- PUNCT O
naïve ADJ O
patients NOUN O
with ADP O
tumours NOUN O
harbouring VERB O
somatic ADJ O
activation NOUN O
of ADP O
PI3K PROPN O
/ SYM O
Akt NOUN O
signalling NOUN O
had VERB O
significantly ADV O
shorter ADJ O
PFS PROPN B-AC
compared VERB O
to ADP O
those PRON O
without ADP O
( PUNCT O
p NOUN O
= SYM O
0.03 NUM O
) PUNCT O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
ALCAM PROPN B-AC
, PUNCT O
activated VERB B-LF
leukocyte NOUN I-LF
cell NOUN I-LF
adhesion NOUN I-LF
molecule NOUN I-LF
; PUNCT O
At PROPN O
, PUNCT O
atria NOUN O
; PUNCT O
CM PROPN B-AC
, PUNCT O
cardiomyocyte NOUN B-LF
; PUNCT O
E PROPN O
, PUNCT O
embryonic ADJ O
day NOUN O
; PUNCT O
EC PROPN B-AC
, PUNCT O
endothelial ADJ B-LF
cell NOUN I-LF
; PUNCT O
EndoC PROPN B-AC
, PUNCT O
endocardial ADJ B-LF
cell NOUN I-LF
; PUNCT O
EPDC PROPN B-AC
, PUNCT O
epicardial ADJ B-LF
- PUNCT I-LF
derived VERB I-LF
cell NOUN I-LF
; PUNCT O
EpiC PROPN B-AC
, PUNCT O
epicardial ADJ B-LF
cell NOUN I-LF
; PUNCT O
FB PROPN B-AC
, PUNCT O
fibroblast NOUN B-LF
; PUNCT O
Gp38 PROPN B-AC
, PUNCT O
glycoprotein NOUN B-LF
38 NUM I-LF
; PUNCT O
GV PROPN B-AC
- PUNCT B-AC
AVJ PROPN B-AC
, PUNCT O
great ADJ B-LF
vessels NOUN I-LF
and CCONJ I-LF
atrioventricular ADJ I-LF
junction NOUN I-LF
; PUNCT O
HSA PROPN B-AC
, PUNCT O
heat NOUN B-LF
stable ADJ I-LF
antigen NOUN I-LF
; PUNCT O
MCAM PROPN B-AC
, PUNCT O
melanoma NOUN B-LF
cell NOUN I-LF
adhesion NOUN I-LF
molecule NOUN I-LF
; PUNCT O
PECAM-1 PROPN B-AC
, PUNCT O
platelet NOUN B-LF
/ SYM I-LF
endothelial ADJ I-LF
cell NOUN I-LF
adhesion NOUN I-LF
molecule NOUN I-LF
1 NUM I-LF
; PUNCT O
PDGFrα PROPN B-AC
, PUNCT O
platelet NOUN B-LF
derived VERB I-LF
growth NOUN I-LF
factor NOUN I-LF
receptor NOUN I-LF
alpha NOUN I-LF
; PUNCT O
Sca-1 PROPN B-AC
, PUNCT O
stem NOUN B-LF
cells NOUN I-LF
antigen NOUN I-LF
1 NUM I-LF
; PUNCT O
SMC PROPN B-AC
, PUNCT O
smooth ADJ B-LF
muscle NOUN I-LF
cell NOUN I-LF
; PUNCT O
Thy1 PROPN B-AC
, PUNCT O
thymus NOUN B-LF
cell NOUN I-LF
antigen NOUN I-LF
1 NUM I-LF
; PUNCT O
Tnnt NOUN B-AC
, PUNCT O
troponin NOUN B-LF
T NOUN I-LF
; PUNCT O
Vt NOUN O
, PUNCT O
ventricle ADJ O

Due ADP O
to ADP O
the DET O
Poisson PROPN O
- PUNCT O
like ADJ O
distribution NOUN O
of ADP O
the DET O
dizziness NOUN O
episodes NOUN O
, PUNCT O
these DET O
data NOUN O
were AUX O
contrasted VERB O
between ADP O
groups NOUN O
with ADP O
negative ADJ O
binomial ADJ O
regression NOUN O
adjusting VERB O
for ADP O
length NOUN O
of ADP O
follow NOUN O
- PUNCT O
up NOUN O
and CCONJ O
the DET O
outcome NOUN O
presented VERB O
as ADP O
a DET O
relative ADJ B-LF
risk NOUN I-LF
( PUNCT O
RR NOUN B-AC
) PUNCT O
( PUNCT O
95 NUM O
% NOUN O
CI NOUN O
) PUNCT O
. PUNCT O
Non ADJ O
- PUNCT O
normally ADV O
distributed ADJ O
continuous ADJ O
variables NOUN O
were AUX O
presented VERB O
as ADP O
median NOUN O
( PUNCT O
interquartile ADJ O
range NOUN O
) PUNCT O
in ADP O
addition NOUN O
to ADP O
mean NOUN O
( PUNCT O
SD NOUN O
) PUNCT O
. PUNCT O
Between ADP O
- PUNCT O
group NOUN O
comparisons NOUN O
of ADP O
retest NOUN O
performance NOUN O
for ADP O
the DET O
continuously ADV O
scored VERB O
primary ADJ O
and CCONJ O
secondary ADJ O
outcome NOUN O
measures NOUN O
were AUX O
made VERB O
using VERB O
generalized ADJ O
linear ADJ O
models NOUN O
controlling VERB O
for ADP O
baseline ADJ O
performance NOUN O
. PUNCT O

BMI PROPN B-AC
: PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
. PUNCT O

To PART O
do VERB O
so ADV O
, PUNCT O
we PRON O
expressed VERB O
green ADJ B-LF
fluorescent NOUN I-LF
protein NOUN I-LF
( PUNCT O
GFP PROPN B-AC
) PUNCT O
[ X O
14 NUM O
] X O
or CCONJ O
tdTomato NOUN B-LF
( PUNCT O
tdT NOUN B-AC
) PUNCT O
[ X O
15 NUM O
] X O
under ADP O
control NOUN O
of ADP O
the DET O
ureA NOUN O
promoter NOUN O
at ADP O
the DET O
rdxA NOUN O
chromosomal ADJ O
locus NOUN O
, PUNCT O
generating VERB O
Hp NOUN B-AC
GFP PROPN B-AC
and CCONJ O
Hp NOUN B-AC
tdT NOUN B-AC
, PUNCT O
respectively ADV O
( PUNCT O
S1A PROPN O
and CCONJ O
S1B PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

Along ADP O
with ADP O
other ADJ O
diagnostic ADJ O
tools NOUN O
, PUNCT O
programmed VERB B-LF
ventricular ADJ I-LF
stimulation NOUN I-LF
( PUNCT O
PVS PROPN B-AC
) PUNCT O
might AUX O
also ADV O
contribute VERB O
to ADP O
an DET O
improved VERB O
risk NOUN O
assessment NOUN O
in ADP O
patients NOUN O
with ADP O
NIDCM PROPN B-AC
. PUNCT O
PVS PROPN B-AC
demonstrated VERB O
clinical ADJ O
relevance NOUN O
in ADP O
the DET O
risk NOUN O
stratification NOUN O
of ADP O
patients NOUN O
with ADP O
ischemic ADJ O
cardiomyopathy NOUN O
[ PUNCT O
17 NUM O
, PUNCT O
18 NUM O
] PUNCT O
. PUNCT O

Sasaki PROPN O
et PROPN O
al NOUN O
. PUNCT O
described VERB O
the DET O
application NOUN O
of ADP O
an DET O
acetaldehyde NOUN B-LF
breath NOUN I-LF
test NOUN I-LF
( PUNCT O
ABT PROPN B-AC
) PUNCT O
to ADP O
distinguish VERB O
between ADP O
ESD PROPN B-AC
treated VERB O
SCC PROPN O
patients NOUN O
and CCONJ O
a DET O
health NOUN O
control NOUN O
group NOUN O
based VERB O
on ADP O
a DET O
cut VERB O
- PUNCT O
off ADP O
value NOUN O
from ADP O
the DET O
previously ADV O
published VERB O
acetaldehyde NOUN O
- PUNCT O
to ADP O
- PUNCT O
ethanol NOUN O
( PUNCT O
A NOUN O
/ SYM O
E NOUN O
) PUNCT O
ratio NOUN O
. PUNCT O

The DET O
paired VERB O
- PUNCT O
end NOUN O
reads NOUN O
generated VERB O
from ADP O
the DET O
anti ADJ O
- PUNCT O
CENH3 ADJ B-AC
ChIP NOUN B-AC
- PUNCT B-AC
seq NOUN B-AC
dataset NOUN O
are AUX O
available ADJ O
under ADP O
the DET O
Gene PROPN B-LF
Expression PROPN I-LF
Omnibus PROPN I-LF
( PUNCT O
GEO PROPN B-AC
) PUNCT O
database NOUN O
( PUNCT O
GSE124242 NOUN O
) PUNCT O
. PUNCT O

Temporal ADJ O
transcriptome NOUN O
profiling NOUN O
at ADP O
different ADJ O
repopulation NOUN O
stages NOUN O
revealed VERB O
that PRON O
adult ADJ O
newborn ADJ O
microglia NOUN O
gradually ADV O
regain VERB O
steady ADJ O
- NOUN O
state NOUN O
maturity NOUN O
from ADP O
an DET O
immature ADJ O
state NOUN O
that PRON O
is AUX O
reminiscent ADJ O
of ADP O
the DET O
neonatal ADJ O
stage NOUN O
and CCONJ O
follow VERB O
a DET O
series NOUN O
of ADP O
maturation NOUN O
programs NOUN O
, PUNCT O
including VERB O
nuclear ADJ B-LF
factor NOUN I-LF
kappa NOUN I-LF
- NOUN I-LF
light NOUN I-LF
- NOUN I-LF
chain NOUN I-LF
- NOUN I-LF
enhancer NOUN I-LF
of ADP I-LF
activated ADJ I-LF
B PROPN I-LF
cells NOUN I-LF
( PUNCT O
NF PROPN B-AC
- NOUN B-AC
κB PROPN B-AC
) PUNCT O
activation NOUN O
, PUNCT O
interferon NOUN O
immune ADJ O
activation NOUN O
, PUNCT O
and CCONJ O
apoptosis NOUN O
. PUNCT O

Autosomal ADJ B-LF
recessive ADJ I-LF
cerebellar ADJ I-LF
ataxias NOUN I-LF
( PUNCT O
ARCAs PROPN B-AC
) PUNCT O
are AUX O
a DET O
large ADJ O
group NOUN O
of ADP O
neurodegenerative ADJ O
disorders NOUN O
that PRON O
manifest VERB O
mainly ADV O
in ADP O
children NOUN O
and CCONJ O
young ADJ O
adults NOUN O
. PUNCT O

It PRON O
is AUX O
central ADJ O
to PART O
efforts NOUN O
to PART O
control VERB O
and CCONJ O
eradicate VERB O
malaria NOUN O
, PUNCT O
and CCONJ O
currently ADV O
estimated VERB O
by ADP O
the DET O
entomological ADJ B-LF
inoculation NOUN I-LF
rate NOUN I-LF
( PUNCT O
EIR PROPN B-AC
) PUNCT O
usually ADV O
interpreted VERB O
as ADP O
the DET O
number NOUN O
of ADP O
infective ADJ O
bites NOUN O
received VERB O
by ADP O
an DET O
individual NOUN O
per ADP O
unit NOUN O
of ADP O
time NOUN O
[ PUNCT O
4 NUM O
] PUNCT O
. PUNCT O

For ADP O
anatomical ADJ O
localization NOUN O
, PUNCT O
the DET O
placement NOUN O
of ADP O
the DET O
MRI NOUN O
fields NOUN O
- PUNCT O
of ADP O
- PUNCT O
view NOUN O
and CCONJ O
slice NOUN O
packages NOUN O
were AUX O
identified VERB O
by ADP O
making VERB O
use NOUN O
of ADP O
1H NOUN O
Rapid PROPN B-LF
Acquisition PROPN I-LF
with ADP I-LF
Relaxation PROPN I-LF
Enhancement PROPN I-LF
( PUNCT O
RARE PROPN B-AC
) PUNCT O
sequences NOUN O
[ PUNCT O
53 NUM O
] PUNCT O
. PUNCT O

Hepatocellular ADJ B-LF
carcinoma NOUN I-LF
( PUNCT O
HCC PROPN B-AC
) PUNCT O
is AUX O
the DET O
most ADV O
common ADJ O
type NOUN O
of ADP O
primary ADJ O
liver NOUN O
cancer NOUN O
in ADP O
adults NOUN O
. PUNCT O

The DET O
incidence NOUN O
Zik(n NOUN O
) PUNCT O
of ADP O
new ADJ O
infections NOUN O
in ADP O
age NOUN O
group NOUN O
i NOUN O
and CCONJ O
risk NOUN O
group NOUN O
k NOUN O
at ADP O
week NOUN O
n NOUN O
is(5)Note X O
that SCONJ O
the DET O
general ADJ B-LF
practitioner NOUN I-LF
( PUNCT O
GP PROPN B-AC
) PUNCT O
consultation NOUN O
and CCONJ O
swabbing NOUN O
data NOUN O
are AUX O
only ADV O
available ADJ O
in ADP O
five NUM O
age NOUN O
groups NOUN O
. PUNCT O

Cox PROPN O
proportional ADJ O
hazards NOUN O
regression NOUN O
was AUX O
used VERB O
to PART O
estimate VERB O
hazard NOUN B-LF
ratios NOUN I-LF
[ PUNCT O
HRs NOUN B-AC
] X O
and CCONJ O
95 NUM O
% NOUN O
confidence NOUN B-LF
intervals NOUN I-LF
[ PUNCT O
CIs NOUN B-AC
] X O
for ADP O
the DET O
association NOUN O
between ADP O
small ADJ O
and CCONJ O
large ADJ O
gestation NOUN O
weight NOUN O
and CCONJ O
mortality NOUN O
over ADP O
time NOUN O
, PUNCT O
using VERB O
attained VERB O
age NOUN O
( PUNCT O
1 NUM O
- PUNCT O
day NOUN O
intervals NOUN O
) PUNCT O
as ADP O
the DET O
underlying VERB O
time NOUN O
scale NOUN O
in ADP O
all DET O
analyses NOUN O
. PUNCT O

Pulmonary ADJ O
hypertension NOUN O
( PUNCT O
assessed VERB O
with ADP O
echocardiography NOUN O
) PUNCT O
also ADV O
can AUX O
indicate VERB O
increased VERB O
risk NOUN O
of ADP O
death NOUN O
for ADP O
patients NOUN O
with ADP O
end ADJ B-LF
- ADJ I-LF
stage NOUN I-LF
renal ADJ I-LF
disease NOUN I-LF
( PUNCT O
ESRD PROPN B-AC
) PUNCT O
[ PUNCT O
21 NUM O
] PUNCT O
. PUNCT O

Where SCONJ O
breech NOUN O
presentation NOUN O
was AUX O
detected VERB O
, PUNCT O
an DET O
external ADJ B-LF
cephalic NOUN I-LF
version NOUN I-LF
( PUNCT O
ECV PROPN B-AC
) PUNCT O
was AUX O
routinely ADV O
offered VERB O
. PUNCT O

The DET O
association NOUN O
was AUX O
interpreted VERB O
using VERB O
the DET O
adjusted VERB B-LF
odds NOUN I-LF
ratio NOUN I-LF
( PUNCT O
AOR PROPN B-AC
) PUNCT O
and CCONJ O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
( PUNCT O
CI NOUN B-AC
) PUNCT O
’ PUNCT O
. PUNCT O

CD4 NOUN B-AC
, PUNCT O
cluster NOUN B-LF
of ADP I-LF
differentiation NOUN I-LF
4 NUM I-LF
. PUNCT O

SD PROPN O
, PUNCT O
standard ADJ O
deviation NOUN O
; PUNCT O
TAF PROPN B-AC
, PUNCT O
tenofovir NOUN B-LF
alafenamide NOUN I-LF
; PUNCT O
TDF PROPN B-AC
, PUNCT O
tenofovir NOUN B-LF
disoproxil NOUN I-LF
fumarate NOUN I-LF
. PUNCT O
* PUNCT O
p<0.05 NUM O
, PUNCT O
†p<0.001 NUM O
. PUNCT O

FRET PROPN O
, PUNCT O
Förster PROPN O
Resonance PROPN O
Energy PROPN O
Transfer PROPN O
; PUNCT O
gH NOUN B-AC
/ SYM B-AC
gL NOUN B-AC
, PUNCT O
glycoproteins NOUN B-LF
H NOUN I-LF
and CCONJ I-LF
L NOUN I-LF
; PUNCT O
LBD PROPN B-AC
, PUNCT O
ligand NOUN B-LF
- PUNCT I-LF
binding VERB I-LF
domain NOUN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

Heart NOUN B-LF
rate NOUN I-LF
( PUNCT O
HR NOUN B-AC
) PUNCT O
, PUNCT O
velocity NOUN O
, PUNCT O
left ADJ B-LF
ventricle NOUN I-LF
( PUNCT O
LV PROPN B-AC
) PUNCT O
mass NOUN O
, PUNCT O
LV PROPN B-LF
internal ADJ I-LF
diameter NOUN I-LF
at ADP I-LF
end NOUN I-LF
- PUNCT I-LF
diastole NOUN I-LF
( PUNCT O
LVID PROPN B-AC
, PUNCT B-AC
d NOUN B-AC
) PUNCT O
, PUNCT O
LV PROPN B-LF
posterior ADJ I-LF
wall NOUN I-LF
thickness NOUN I-LF
at ADP I-LF
end NOUN I-LF
- PUNCT I-LF
diastole NOUN I-LF
( PUNCT O
LVPW PROPN B-AC
, PUNCT B-AC
d NOUN B-AC
) PUNCT O
, PUNCT O
LV PROPN B-LF
anterior ADJ I-LF
wall NOUN I-LF
thickness NOUN I-LF
at ADP I-LF
end NOUN I-LF
- PUNCT I-LF
diastole NOUN I-LF
( PUNCT O
LVAW PROPN B-AC
, PUNCT B-AC
d NOUN B-AC
) PUNCT O
, PUNCT O
ejection NOUN B-LF
fraction NOUN I-LF
( PUNCT O
EF PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
fractional ADJ B-LF
shortening NOUN I-LF
( PUNCT O
FS PROPN B-AC
) PUNCT O
of ADP O
the DET O
LV PROPN B-AC
were AUX O
measured VERB O
. PUNCT O

Odds NOUN B-LF
ratios NOUN I-LF
( PUNCT O
OR NOUN B-AC
) PUNCT O
were AUX O
computed VERB O
to PART O
determine VERB O
of ADP O
associations NOUN O
between ADP O
variables NOUN O
at ADP O
95 NUM O
% NOUN O
Confidence NOUN B-LF
Intervals NOUN I-LF
( PUNCT O
CIs NOUN B-AC
) PUNCT O
. PUNCT O

For ADP O
this DET O
study NOUN O
, PUNCT O
we PRON O
excluded VERB O
the DET O
respondents NOUN O
where SCONJ O
the DET O
outcome NOUN O
variable NOUN O
( PUNCT O
place NOUN O
of ADP O
delivery NOUN O
) PUNCT O
was AUX O
missed VERB O
and CCONJ O
for ADP O
the DET O
spatial ADJ O
analysis NOUN O
, PUNCT O
we PRON O
excluded VERB O
those DET O
women NOUN O
in ADP O
the DET O
Enumeration PROPN B-LF
Areas PROPN I-LF
( PUNCT O
EAs PROPN B-AC
) PUNCT O
with ADP O
zero NUM O
latitudes NOUN O
and CCONJ O
longitude NOUN O
. PUNCT O

The DET O
waist NOUN B-LF
circumference NOUN I-LF
( PUNCT O
WC NOUN B-AC
, PUNCT O
cm NOUN O
) PUNCT O
was AUX O
measured VERB O
midway ADV O
between ADP O
the DET O
costal ADJ O
margin NOUN O
and CCONJ O
the DET O
iliac ADJ O
crest NOUN O
at ADP O
the DET O
end NOUN O
of ADP O
a DET O
normal ADJ O
expiration NOUN O
. PUNCT O

The DET O
sample NOUN O
size NOUN O
calculation NOUN O
assumed VERB O
that SCONJ O
40 NUM O
% PUNCT O
of ADP O
participants NOUN O
would AUX O
have VERB O
well ADV O
- PUNCT O
controlled VERB O
HbA1c NOUN B-AC
( PUNCT O
< PUNCT O
7 NUM O
% PUNCT O
) PUNCT O
at ADP O
EOS PROPN B-AC
in ADP O
the DET O
control NOUN O
group NOUN O
, PUNCT O
with ADP O
an DET O
intraclass NOUN B-LF
correlation NOUN I-LF
coefficient NOUN I-LF
( PUNCT O
ICC NOUN B-AC
) PUNCT O
of ADP O
0.15 NUM O
. PUNCT O

KO PROPN B-AC
, PUNCT O
knockout NOUN B-LF
; PUNCT O
SG PROPN B-AC
, PUNCT O
slow ADJ B-LF
gamma NOUN I-LF
. PUNCT O

Peripheral ADJ B-LF
Blood NOUN I-LF
mononuclear ADJ I-LF
cells NOUN I-LF
( PUNCT O
PBMC PROPN B-AC
) PUNCT O
were AUX O
isolated VERB O
using VERB O
Ficoll PROPN O
- PUNCT O
Paque PROPN O
density NOUN O
gradient NOUN O
centrifugation NOUN O
and CCONJ O
samples NOUN O
were AUX O
stored VERB O
in ADP O
fetal ADJ O
bovine ADJ O
serum NOUN O
( PUNCT O
FBS PROPN O
) PUNCT O
( PUNCT O
Biowest PROPN O
) PUNCT O
supplemented VERB O
with ADP O
10 NUM O
% NOUN O
DMSO PROPN O
( PUNCT O
Sigma PROPN O
- PUNCT O
Aldrich PROPN O
) PUNCT O
at ADP O
-150 NUM O
° NOUN O
C NOUN O
. PUNCT O

While SCONJ O
, PUNCT O
since SCONJ O
the DET O
beginning NOUN O
of ADP O
Highly ADV O
Active PROPN O
Antiretroviral PROPN O
Therapy(HAART PROPN B-AC
) PUNCT O
has VERB O
made VERB O
great ADJ O
progress NOUN O
in ADP O
improving VERB O
the DET O
longevity NOUN O
and CCONJ O
quality NOUN O
of ADP O
life NOUN O
of ADP O
people NOUN B-LF
living VERB I-LF
with ADP I-LF
HIV PROPN I-LF
( PUNCT O
PLWHIV PROPN B-AC
) PUNCT O
, PUNCT O
treatment NOUN O
is AUX O
not PART O
risk NOUN O
- PUNCT O
free ADJ O
or CCONJ O
has VERB O
side NOUN O
effects NOUN O
. PUNCT O

In ADP O
addition NOUN O
, PUNCT O
we PRON O
engineered VERB O
a DET O
retrovirus NOUN O
to PART O
express VERB O
the DET O
oligomerization NOUN B-LF
domain NOUN I-LF
of ADP I-LF
p53 NOUN I-LF
( PUNCT O
DDp53 NOUN B-AC
) PUNCT O
, PUNCT O
which PRON O
also ADV O
inhibits VERB O
p53 NOUN O
activity NOUN O
[ X O
26 NUM O
] PUNCT O
. PUNCT O

DiI PROPN B-AC
, PUNCT O
1,19 NUM B-LF
- PUNCT I-LF
dioctadecyl-3,3,39,39 NOUN I-LF
- PUNCT I-LF
tetramethylindocarbocyanine NOUN I-LF
perchlorate NOUN I-LF
; PUNCT O
WGA PROPN B-AC
, PUNCT O
wheat NOUN B-LF
germ NOUN I-LF
agglutinin NOUN I-LF
. PUNCT O

Each DET O
imperfect ADJ O
tandem NOUN O
repeat NOUN O
encodes VERB O
50–53 NUM O
amino NOUN O
acid NOUN O
residues NOUN O
and CCONJ O
contains VERB O
three NUM O
α NOUN O
- PUNCT O
helices NOUN O
, PUNCT O
the DET O
second ADJ O
and CCONJ O
third ADJ O
of ADP O
which PRON O
form VERB O
a DET O
helix NOUN B-LF
- PUNCT I-LF
turn NOUN I-LF
- PUNCT I-LF
helix NOUN I-LF
( PUNCT O
HTH PROPN B-AC
) PUNCT O
motif NOUN O
[ PUNCT O
7 NUM O
] PUNCT O
. PUNCT O

Today NOUN O
's PART O
TB PROPN B-AC
treatment NOUN O
, PUNCT O
which PRON O
dates VERB O
back ADV O
to ADP O
the DET O
1970s NOUN O
, PUNCT O
is AUX O
long ADJ O
and CCONJ O
burdensome ADJ O
, PUNCT O
requiring VERB O
at ADV O
least ADV O
6 NUM O
mo NOUN O
of ADP O
multidrug NOUN O
chemotherapy NOUN O
, PUNCT O
typically ADV O
consisting VERB O
of ADP O
rifampicin NOUN B-LF
( PUNCT O
RFP PROPN B-AC
) PUNCT O
, PUNCT O
isoniazid NOUN B-LF
( PUNCT O
INH PROPN B-AC
) PUNCT O
, PUNCT O
ethambutol NOUN B-LF
( PUNCT O
EB PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
pyrazinamide NOUN B-LF
( PUNCT O
PZA PROPN B-AC
) PUNCT O
given VERB O
under ADP O
clinically ADV O
observed ADJ O
conditions NOUN O
. PUNCT O

ICS PROPN B-AC
, PUNCT O
inhaled VERB B-LF
corticosteroid NOUN I-LF

The DET O
diagnosis NOUN O
of ADP O
HCC PROPN B-AC
was AUX O
confirmed VERB O
based VERB O
on ADP O
HCC PROPN B-AC
management NOUN O
guidelines NOUN O
from ADP O
EASL PROPN B-AC
or CCONJ O
AASLD.[2 PROPN B-AC
, PUNCT O
3 NUM O
] PUNCT O
Performance NOUN O
status NOUN O
was AUX O
determined VERB O
when SCONJ O
HCC PROPN B-AC
diagnosis NOUN O
was AUX O
made.[14 VERB O
] PUNCT O
Total ADJ B-LF
tumor NOUN I-LF
volume NOUN I-LF
( PUNCT O
TTV PROPN B-AC
) PUNCT O
was AUX O
calculated VERB O
based VERB O
on ADP O
tumor NOUN O
diameter.[15 NOUN O
] PUNCT O
Patients NOUN O
were AUX O
censored VERB O
at ADP O
time NOUN O
of ADP O
liver NOUN O
transplantation NOUN O
if SCONJ O
they PRON O
received VERB O
transplantation NOUN O
as ADP O
salvage NOUN O
therapy NOUN O
. PUNCT O

The DET O
letters NOUN O
indicate VERB O
the DET O
corresponding ADJ O
values NOUN O
for ADP O
the DET O
samples NOUN O
in ADP O
panels NOUN O
( PUNCT O
A NOUN O
– SYM O
D NOUN O
) PUNCT O
for ADP O
comparison NOUN O
. PUNCT O
( PUNCT O
F X O
) PUNCT O
The DET O
distribution NOUN O
of ADP O
quasi ADJ B-LF
- ADJ I-LF
phaseable ADJ I-LF
( PUNCT O
QP PROPN B-AC
) PUNCT O
samples NOUN O
among ADP O
the DET O
35 NUM O
most ADV O
prevalent ADJ O
species NOUN O
, PUNCT O
arranged VERB O
by ADP O
descending VERB O
prevalence NOUN O
; PUNCT O
the DET O
distribution NOUN O
across ADP O
hosts NOUN O
is AUX O
shown VERB O
in ADP O
S7 PROPN O
Fig NOUN O
. PUNCT O

In ADP O
this DET O
study NOUN O
, PUNCT O
we PRON O
consider VERB O
3 NUM O
factors NOUN O
that PRON O
could AUX O
plausibly ADV O
modulate VERB O
the DET O
risk NOUN O
reduction NOUN O
effectiveness NOUN O
of ADP O
weight NOUN O
loss NOUN O
: PUNCT O
initial ADJ O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT O
BMI PROPN B-AC
, PUNCT O
defined VERB O
as ADP O
weight NOUN O
in ADP O
kilograms NOUN O
divided VERB O
by ADP O
squared VERB O
height NOUN O
in ADP O
meters NOUN O
) PUNCT O
, PUNCT O
family NOUN O
history NOUN O
( PUNCT O
whether SCONJ O
a DET O
mother NOUN O
, PUNCT O
father NOUN O
, PUNCT O
or CCONJ O
sibling NOUN O
has VERB O
diabetes NOUN O
) PUNCT O
, PUNCT O
and CCONJ O
genetic ADJ O
risk NOUN O
according VERB O
to ADP O
a DET O
polygenic ADJ O
risk NOUN O
score NOUN O
constructed VERB O
from ADP O
over ADP O
100,000 NUM O
DNA NOUN O
sequence NOUN O
polymorphisms NOUN O
based VERB O
on ADP O
their PRON O
association NOUN O
with ADP O
type NOUN O
2 NUM O
diabetes NOUN O
in ADP O
a DET O
recent ADJ O
genome NOUN O
- PUNCT O
wide ADJ O
association NOUN O
study NOUN O
[ PUNCT O
14 NUM O
] PUNCT O
. PUNCT O

Non ADJ B-LF
- ADJ I-LF
alcoholic ADJ I-LF
fatty ADJ I-LF
liver NOUN I-LF
disease NOUN I-LF
( PUNCT O
NAFLD PROPN B-AC
) PUNCT O
is AUX O
increasingly ADV O
common ADJ O
in ADP O
the DET O
adult NOUN O
population NOUN O
. PUNCT O

For ADP O
the DET O
logit NOUN O
and CCONJ O
negative ADJ O
binomial ADJ O
models NOUN O
, PUNCT O
the DET O
interaction NOUN O
terms NOUN O
are AUX O
not PART O
relative ADJ B-LF
risks NOUN I-LF
( PUNCT O
RRs NOUN B-AC
) PUNCT O
or CCONJ O
odds NOUN B-LF
ratios NOUN I-LF
( PUNCT O
ORs NOUN B-AC
) PUNCT O
per X O
se X O
, PUNCT O
but CCONJ O
rather ADV O
are AUX O
the DET O
post ADJ O
- NOUN O
intervention NOUN O
ratios NOUN O
divided VERB O
by ADP O
the DET O
pre ADJ O
- NOUN O
intervention NOUN O
ratios NOUN O
: PUNCT O
a DET O
result NOUN O
less ADJ O
than ADP O
one NUM O
indicates VERB O
positive ADJ O
intervention NOUN O
effectiveness NOUN O
. PUNCT O

The DET O
key ADJ O
enzymes NOUN O
in ADP O
the DET O
MVA PROPN O
pathway NOUN O
mainly ADV O
include VERB O
HMGS PROPN B-AC
( PUNCT O
3 NUM B-LF
- NOUN I-LF
hydroxy-3 NOUN I-LF
- NOUN I-LF
methylglutaryl NOUN I-LF
CoA NOUN I-LF
synthase NOUN I-LF
) PUNCT O
, PUNCT O
HMGR PROPN B-AC
( PUNCT O
3 NUM B-LF
- NOUN I-LF
hydroxy-3 NOUN I-LF
- NOUN I-LF
methyl NOUN I-LF
glutaryl NOUN I-LF
CoA NOUN I-LF
reductase NOUN I-LF
) PUNCT O
, PUNCT O
MK PROPN B-AC
( PUNCT O
mevalonate NOUN B-LF
kinase NOUN I-LF
) PUNCT O
, PUNCT O
FPPS PROPN B-AC
( PUNCT O
farnesyl NOUN B-LF
diphosphate NOUN I-LF
synthase NOUN I-LF
) PUNCT O
and CCONJ O
SS PROPN B-AC
( PUNCT O
squalene NOUN B-LF
synthase NOUN I-LF
) PUNCT O
( PUNCT O
Fig NOUN O
6 NUM O
) PUNCT O
. PUNCT O

Prognostic ADJ O
factors NOUN O
were AUX O
identified VERB O
using VERB O
the DET O
least ADJ B-LF
absolute ADJ I-LF
shrinkage NOUN I-LF
and CCONJ I-LF
selection NOUN I-LF
operator NOUN I-LF
( PUNCT O
LASSO)-based PROPN B-AC
normal ADJ B-LF
tissue NOUN I-LF
complication NOUN I-LF
probability NOUN I-LF
( PUNCT O
NTCP PROPN B-AC
) PUNCT O
model NOUN O
. PUNCT O

For ADP O
susceptible ADJ O
patients NOUN O
, PUNCT O
1 NUM O
day NOUN O
in ADP O
the DET O
same ADJ O
ward NOUN O
with ADP O
another DET O
patient NOUN O
with ADP O
hospital NOUN O
- PUNCT O
acquired VERB O
SARS PROPN B-AC
- PUNCT B-AC
CoV-2 PROPN B-AC
was AUX O
associated VERB O
with ADP O
an DET O
additional ADJ O
7.5 NUM O
infections NOUN O
per ADP O
1,000 NUM O
susceptible ADJ O
patients NOUN O
( PUNCT O
95 NUM O
% NOUN O
credible ADJ B-LF
interval NOUN I-LF
( PUNCT O
CrI PROPN B-AC
) PUNCT O
5.5 NUM O
to PART O
9.5/1,000 NUM O
susceptible ADJ O
patients NOUN O
/ SYM O
day NOUN O
) PUNCT O
per ADP O
day NOUN O
. PUNCT O

We PRON O
assessed VERB O
the DET O
quality NOUN O
of ADP O
evidence NOUN O
for ADP O
each DET O
outcome NOUN O
using VERB O
Grading PROPN B-LF
of ADP I-LF
Recommendations PROPN I-LF
Assessment PROPN I-LF
, PUNCT I-LF
Development PROPN I-LF
and CCONJ I-LF
Evaluation PROPN I-LF
( PUNCT O
GRADE PROPN B-AC
) PUNCT O
criteria NOUN O
, PUNCT O
and CCONJ O
these DET O
results NOUN O
can AUX O
be AUX O
found VERB O
in ADP O
S1 PROPN O
Table PROPN O
[ PUNCT O
22 NUM O
] PUNCT O
. PUNCT O

Dyslipidemia NOUN O
was AUX O
defined VERB O
as ADP O
a DET O
total ADJ B-LF
cholesterol NOUN I-LF
( PUNCT O
TC PROPN B-AC
) PUNCT O
level NOUN O
≥220 NUM O
mg NOUN O
/ SYM O
dL NOUN O
, PUNCT O
low ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
- PUNCT I-LF
cholesterol NOUN I-LF
( PUNCT O
LDL NOUN B-AC
- PUNCT B-AC
C PROPN B-AC
) PUNCT O
level NOUN O
≥140 NUM O
mg NOUN O
/ SYM O
dL NOUN O
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
- PUNCT I-LF
cholesterol NOUN I-LF
( PUNCT O
HDL PROPN B-AC
- PUNCT B-AC
C PROPN B-AC
) PUNCT O
level NOUN O
< ADJ O
40 NUM O
mg NOUN O
/ SYM O
dL NOUN O
, PUNCT O
or CCONJ O
the DET O
current ADJ O
use NOUN O
of ADP O
lipid NOUN O
- PUNCT O
lowering VERB O
agents NOUN O
. PUNCT O

Studies NOUN O
that PRON O
reported VERB O
a DET O
treatment NOUN O
success NOUN O
rate NOUN O
over ADP O
70 NUM O
% NOUN O
showed VERB O
a DET O
trend NOUN O
toward ADP O
a DET O
better ADJ O
improvement NOUN O
in ADP O
the DET O
PCS PROPN B-AC
( PUNCT O
A NOUN O
) PUNCT O
and CCONJ O
a DET O
significantly ADV O
better ADJ O
improvement NOUN O
in ADP O
the DET O
MCS PROPN B-AC
( PUNCT O
B NOUN O
) PUNCT O
. PUNCT O
CI NOUN O
: PUNCT O
confidence NOUN O
intervals NOUN O
; PUNCT O
MCS PROPN B-AC
: PUNCT O
mental ADJ B-LF
component NOUN I-LF
summary NOUN I-LF
score NOUN I-LF
; PUNCT O
PCS PROPN B-AC
: PUNCT O
physical ADJ B-LF
component NOUN I-LF
summary NOUN I-LF
score NOUN I-LF
; PUNCT O
RFCA NOUN B-AC
: PUNCT O
radiofrequency NOUN B-LF
catheter NOUN I-LF
ablation NOUN I-LF
. PUNCT O

This DET O
table NOUN O
lists VERB O
the DET O
human ADJ O
qPCR NOUN B-AC
primers NOUN O
. PUNCT O
qPCR NOUN B-AC
, PUNCT O
quantitative ADJ B-LF
PCR NOUN I-LF
. PUNCT O

Tracheobronchial ADJ O
basal ADJ O
cells NOUN O
proliferating VERB O
on ADP O
plastic NOUN O
were AUX O
infected VERB O
with SCONJ O
Lenti PROPN O
- PUNCT O
SOX2 PROPN O
or CCONJ O
empty ADJ O
vector NOUN O
, PUNCT O
with SCONJ O
mean NOUN O
expression NOUN O
± SYM O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean NOUN I-LF
( PUNCT O
SEM PROPN B-AC
) PUNCT O
from ADP O
three NUM O
biological ADJ O
replicate NOUN O
experiments NOUN O
shown VERB O
. PUNCT O

ENSANUT PROPN B-AC
, PUNCT O
Encuesta PROPN B-LF
Nacional PROPN I-LF
de ADP I-LF
Salud PROPN I-LF
y CCONJ I-LF
Nutrición PROPN I-LF
; PUNCT O
SE PROPN B-AC
, PUNCT O
standard ADJ B-LF
error NOUN I-LF
; PUNCT O
SSB PROPN B-AC
, PUNCT O
sugar NOUN B-LF
- PUNCT I-LF
sweetened VERB I-LF
beverage NOUN I-LF
. PUNCT O

Dˊ NOUN B-AC
( PUNCT O
normalized VERB B-LF
deviation NOUN I-LF
) PUNCT O
is AUX O
used VERB O
to PART O
measure VERB O
the DET O
LD NOUN B-AC
between ADP O
a DET O
pair NOUN O
of ADP O
SNPs NOUN B-AC
. PUNCT O
CI NOUN O
is AUX O
used VERB O
to PART O
assess VERB O
the DET O
reliability NOUN O
of ADP O
the DET O
estimate NOUN O
of ADP O
Dˊ. NOUN B-AC
Strong ADJ O
LD NOUN B-AC
is AUX O
defined VERB O
as SCONJ O
the DET O
upper ADJ O
limit NOUN O
of ADP O
the DET O
90 NUM O
% NOUN O
CI NOUN O
is AUX O
( PUNCT O
0.98 NUM O
) PUNCT O
, PUNCT O
and CCONJ O
the DET O
lower ADJ O
limit NOUN O
is AUX O
( PUNCT O
0.7 NUM O
) PUNCT O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
MRSA PROPN B-AC
: PUNCT O
methicillin NOUN O
- PUNCT O
resistant ADJ O
Staphylococcus PROPN O
aureus NOUN O
, PUNCT O
CI NOUN B-AC
: PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
. PUNCT O

Then ADV O
, PUNCT O
construct NOUN O
validity NOUN O
of ADP O
the DET O
single ADJ O
factor NOUN O
CBI PROPN B-AC
was AUX O
assessed VERB O
using VERB O
Confirmatory PROPN B-LF
Factor PROPN I-LF
Analysis PROPN I-LF
( PUNCT O
CFA PROPN B-AC
) PUNCT O
. PUNCT O
Since SCONJ O
one NUM O
factor NOUN O
CBI PROPN B-AC
was AUX O
not PART O
confirmed VERB O
, PUNCT O
construct NOUN O
validity NOUN O
was AUX O
examined VERB O
using VERB O
Exploratory PROPN B-LF
Factor PROPN I-LF
Analysis PROPN I-LF
( PUNCT O
EFA PROPN B-AC
) PUNCT O
. PUNCT O
The DET O
final ADJ O
number NOUN O
of ADP O
factors NOUN O
was AUX O
confirmed VERB O
using VERB O
CFA PROPN B-AC
. PUNCT O

An DET O
abnormal ADJ O
presence NOUN O
of ADP O
these DET O
proteins NOUN O
would AUX O
be AUX O
a DET O
better ADJ O
marker NOUN O
of ADP O
kidney NOUN O
lesions NOUN O
and CCONJ O
would AUX O
precede VERB O
glomerular ADJ B-LF
filtration NOUN I-LF
rate NOUN I-LF
( PUNCT O
GFR PROPN B-AC
) PUNCT O
decrease NOUN O
and CCONJ O
serum NOUN B-LF
creatinine NOUN I-LF
( PUNCT O
sCr NOUN B-AC
) PUNCT O
increase NOUN O
. PUNCT O

At ADP O
2 NUM O
days NOUN B-LF
after ADP I-LF
pollination NOUN I-LF
( PUNCT O
DAP PROPN B-AC
) PUNCT O
, PUNCT O
when SCONJ O
the DET O
majority NOUN O
of ADP O
wild ADJ O
- ADJ O
type NOUN O
embryos NOUN O
had AUX O
undergone VERB O
two NUM O
or CCONJ O
three NUM O
cell NOUN O
divisions NOUN O
( PUNCT O
two- NUM O
to ADP O
four NUM O
- ADJ O
cell NOUN O
embryo NOUN O
proper ADJ O
) PUNCT O
, PUNCT O
the DET O
majority NOUN O
of ADP O
mutant ADJ O
embryos NOUN O
had AUX O
divided VERB O
only ADV O
once ADV O
or CCONJ O
not PART O
at ADP O
all DET O
( PUNCT O
Figure PROPN O
S7A NOUN O
and CCONJ O
S7C NOUN O
– SYM O
E NOUN O
) PUNCT O
. PUNCT O
Endosperm NOUN O
development NOUN O
was AUX O
delayed VERB O
in ADP O
comparison NOUN O
to ADP O
the DET O
wild ADJ O
type NOUN O
( PUNCT O
Figure PROPN O
S7C NOUN O
– SYM O
E NOUN O
) PUNCT O
. PUNCT O
At ADP O
3 NUM O
DAP PROPN B-AC
, PUNCT O
a DET O
proportion NOUN O
of ADP O
unfertilized ADJ O
ovules NOUN O
and CCONJ O
seeds NOUN O
( PUNCT O
likely ADV O
arrested VERB O
around ADP O
the DET O
zygote NOUN O
stage NOUN O
) PUNCT O
had AUX O
started VERB O
degeneration NOUN O
and CCONJ O
collapsed VERB O
( PUNCT O
Figure PROPN O
6E NUM O
, PUNCT O
Figure PROPN O
S7B NOUN O
and CCONJ O
S7F NOUN O
) PUNCT O
. PUNCT O
Only ADV O
about ADV O
10 NUM O
% NOUN O
of ADP O
embryos NOUN O
with ADP O
a DET O
developmental ADJ O
delay NOUN O
developed VERB O
into ADP O
a DET O
two- NUM O
or CCONJ O
four NUM O
- ADJ O
cell NOUN O
embryo NOUN O
, PUNCT O
while SCONJ O
the DET O
majority NOUN O
of ADP O
wild ADJ O
- ADJ O
type NOUN O
embryos NOUN O
had AUX O
reached VERB O
the DET O
octant ADJ O
or CCONJ O
early ADJ O
globular ADJ O
stage NOUN O
( PUNCT O
Figure PROPN O
S7B NOUN O
) PUNCT O
. PUNCT O
At ADP O
4 NUM O
DAP PROPN B-AC
, PUNCT O
the DET O
majority NOUN O
of ADP O
arrested VERB O
seeds NOUN O
had AUX O
collapsed VERB O
and CCONJ O
only ADV O
infrequently ADV O
, PUNCT O
in ADP O
about ADV O
1 NUM O
% NOUN O
of ADP O
all DET O
ovules NOUN O
and CCONJ O
seeds NOUN O
( PUNCT O
N NOUN O
= SYM O
149 NUM O
) PUNCT O
, PUNCT O
arrest NOUN O
at ADP O
the DET O
mid ADJ O
- ADJ O
globular ADJ O
stage NOUN O
was AUX O
observed VERB O
( PUNCT O
Figure PROPN O
6 NUM O
G NOUN O
) PUNCT O
. PUNCT O

One NUM O
key ADJ O
example NOUN O
of ADP O
effectiveness NOUN O
was AUX O
the DET O
European ADJ O
DE PROPN B-AC
- PUNCT B-AC
PLAN PROPN B-AC
( PUNCT O
Diabetes NOUN B-LF
in ADP I-LF
Europe PROPN I-LF
– PUNCT I-LF
Prevention PROPN I-LF
using VERB I-LF
lifestyle NOUN I-LF
, PUNCT I-LF
physical ADJ I-LF
activity NOUN I-LF
and CCONJ I-LF
nutritional ADJ I-LF
intervention NOUN I-LF
) PUNCT O
project NOUN O
applied VERB O
in ADP O
Catalonia PROPN O
( PUNCT O
DE PROPN B-AC
- PUNCT B-AC
PLAN PROPN B-AC
- PUNCT O
CAT PROPN O
) PUNCT O
. PUNCT O
Diabetes NOUN O
incidence NOUN O
was AUX O
reduced VERB O
by ADP O
36.5 NUM O
% NOUN O
at ADP O
the DET O
4 NUM O
- PUNCT O
year NOUN O
follow NOUN O
- PUNCT O
up NOUN O
in ADP O
333 NUM O
participants NOUN O
carrying VERB O
out ADP O
the DET O
intensive ADJ O
lifestyle NOUN O
intervention NOUN O
compared VERB O
to ADP O
the DET O
standard ADJ O
care NOUN O
regime NOUN O
[ PUNCT O
10 NUM O
] PUNCT O
. PUNCT O

TE PROPN B-AC
, PUNCT O
translational ADJ B-LF
efficiency NOUN I-LF
; PUNCT O
uORF PROPN B-AC
, PUNCT O
upstream ADJ B-LF
open ADJ I-LF
reading NOUN I-LF
frame NOUN I-LF
. PUNCT O

Finally ADV O
, PUNCT O
we PRON O
performed VERB O
association NOUN O
analysis NOUN O
of ADP O
both DET O
imputed ADJ O
data NOUN O
sets NOUN O
for ADP O
the DET O
Low ADJ B-LF
- PUNCT I-LF
Density NOUN I-LF
lipoprotein NOUN I-LF
concentration NOUN I-LF
( PUNCT O
LDL NOUN B-AC
- PUNCT B-AC
C NOUN B-AC
) PUNCT O
phenotype NOUN O
relevant ADJ O
for ADP O
premature ADJ O
cardio ADJ O
atherosclerotic ADJ O
disease NOUN O
. PUNCT O

Since SCONJ O
then ADV O
, PUNCT O
numerous ADJ O
other ADJ O
VOCs NOUN B-AC
have AUX O
been AUX O
identified VERB O
through ADP O
genomic ADJ O
sequencing NOUN O
of ADP O
positive ADJ O
cases NOUN O
worldwide ADV O
; PUNCT O
most ADV O
notably ADV O
with ADP O
in ADP O
the DET O
UK PROPN O
with ADP O
COVID-19 PROPN B-LF
Genomics PROPN I-LF
UK PROPN I-LF
Consortium PROPN I-LF
( PUNCT O
COG PROPN B-AC
- PUNCT B-AC
UK PROPN B-AC
) PUNCT O
[ PUNCT O
18 NUM O
] PUNCT O
. PUNCT O

Regulation NOUN O
of ADP O
miRNAs NOUN B-AC
were AUX O
interlinked VERB O
with ADP O
upstream ADJ O
regulators NOUN O
such ADJ O
as ADP O
Argonaut PROPN O
2 NUM O
( PUNCT O
AGO2 PROPN O
) PUNCT O
, PUNCT O
Double PROPN B-LF
- PUNCT I-LF
Stranded PROPN I-LF
RNA PROPN I-LF
- PUNCT I-LF
Specific PROPN I-LF
Endoribonuclease NOUN I-LF
( PUNCT O
DICER1 PROPN B-AC
) PUNCT O
, PUNCT O
Sjogren PROPN B-LF
syndrome PROPN I-LF
antigen NOUN I-LF
B PROPN I-LF
( PUNCT O
SSB PROPN B-AC
) PUNCT O
, PUNCT O
neurofibromatosis NOUN B-LF
2 NUM I-LF
( PUNCT O
NF2 PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
peroxisome NOUN B-LF
proliferator NOUN I-LF
activated VERB I-LF
receptor NOUN I-LF
alpha NOUN I-LF
( PUNCT O
PPARA PROPN B-AC
) PUNCT O
, PUNCT O
activated VERB O
during ADP O
stage NOUN O
- PUNCT O
specific ADJ O
disease NOUN O
progression NOUN O
. PUNCT O

Further ADV O
, PUNCT O
some DET O
meta NOUN O
- PUNCT O
heuristic NOUN O
based VERB O
techniques NOUN O
, PUNCT O
for ADP O
example NOUN O
, PUNCT O
Whale PROPN B-LF
Optimization PROPN I-LF
Algorithm PROPN I-LF
( PUNCT O
WOA PROPN B-AC
) PUNCT O
[ X O
25 NUM O
] PUNCT O
, PUNCT O
Moth PROPN B-LF
- PUNCT I-LF
Flame PROPN I-LF
Optimization PROPN I-LF
Algorithm PROPN I-LF
( PUNCT O
MFO PROPN B-AC
) PUNCT O
[ X O
26 NUM O
] PUNCT O
, PUNCT O
Glowworm PROPN O
Swarm PROPN O
Optimization PROPN O
Algorithm PROPN O
( PUNCT O
GSO PROPN B-AC
) PUNCT O
[ X O
27 NUM O
] PUNCT O
, PUNCT O
Jaya PROPN B-LF
Algorithm PROPN I-LF
( PUNCT O
JA PROPN B-AC
) PUNCT O
[ X O
28 NUM O
] PUNCT O
, PUNCT O
Artificial PROPN B-LF
Bee PROPN I-LF
Colony PROPN I-LF
Algorithm PROPN I-LF
( PUNCT O
ABC PROPN B-AC
) PUNCT O
[ X O
29 NUM O
] PUNCT O
were AUX O
employed VERB O
to PART O
solve VERB O
OPF PROPN B-AC
problem NOUN O
effectively ADV O
and CCONJ O
accurately ADV O
. PUNCT O

Plasma NOUN O
free ADJ B-LF
fatty ADJ I-LF
acid NOUN I-LF
( PUNCT O
FFA PROPN B-AC
) PUNCT O
levels NOUN O
( PUNCT O
in ADP O
μmol NOUN O
/ SYM O
L NOUN O
) PUNCT O
were AUX O
determined VERB O
enzymatically ADV O
( PUNCT O
NEFAC PROPN O
kit NOUN O
, PUNCT O
WAKO PROPN O
Chemicals PROPN O
, PUNCT O
Neuss PROPN O
, PUNCT O
Germany PROPN O
) PUNCT O
. PUNCT O

We PRON O
report VERB O
here ADV O
the DET O
discovery NOUN O
of ADP O
a DET O
novel ADJ O
lantibiotic NOUN O
for ADP O
the DET O
treatment NOUN O
of ADP O
C. NOUN B-LF
difficile ADJ I-LF
infection NOUN I-LF
( PUNCT O
CDI PROPN B-AC
) PUNCT O
. PUNCT O
The DET O
leads NOUN O
were AUX O
selected VERB O
from ADP O
a DET O
library NOUN O
of ADP O
over ADP O
300 NUM O
multiple ADJ O
substitution NOUN O
variants NOUN O
of ADP O
the DET O
lantibiotic NOUN O
Mutacin PROPN B-LF
1140 NUM I-LF
( PUNCT O
MU1140 PROPN B-AC
) PUNCT O
. PUNCT O

We PRON O
therefore ADV O
sought VERB O
to PART O
investigate VERB O
this DET O
question NOUN O
in ADP O
a DET O
large ADJ O
case NOUN O
- PUNCT O
cohort NOUN O
study NOUN O
nested VERB O
within ADP O
the DET O
European PROPN B-LF
Prospective PROPN I-LF
Investigation PROPN I-LF
into ADP I-LF
Cancer PROPN I-LF
and CCONJ I-LF
Nutrition PROPN I-LF
( PUNCT O
EPIC PROPN B-AC
) PUNCT O
study NOUN O
. PUNCT O

BMAL1 PROPN O
, PUNCT O
brain NOUN O
and CCONJ O
muscle NOUN O
ARNT NOUN O
- PUNCT O
like ADJ O
protein NOUN O
1 NUM O
; PUNCT O
CLOCK PROPN B-AC
, PUNCT O
circadian ADJ B-LF
locomotor ADJ I-LF
output NOUN I-LF
cycles NOUN I-LF
protein NOUN I-LF
kaput NOUN I-LF
; PUNCT O
JMJD5 PROPN B-AC
, PUNCT O
JmjC PROPN B-LF
domain NOUN I-LF
– PUNCT I-LF
containing VERB I-LF
protein NOUN I-LF
5 NUM I-LF
. PUNCT O

Queensland PROPN O
includes VERB O
443 NUM O
postal ADJ O
areas NOUN O
( PUNCT O
Australian PROPN O
Bureau PROPN O
of ADP O
Statistics PROPN O
, PUNCT O
postal ADJ O
areas NOUN O
Australian PROPN B-LF
Statistical PROPN I-LF
Geography PROPN I-LF
Standard PROPN I-LF
[ PUNCT O
ASGS PROPN B-AC
] X O
Edition PROPN O
2016 NUM O
) PUNCT O
. PUNCT O

Pro NOUN B-LF
- NOUN I-LF
myeloperoxidase NOUN I-LF
( PUNCT O
pro NOUN B-AC
- NOUN B-AC
MPO PROPN B-AC
) PUNCT O
, PUNCT O
an DET O
enzymatically ADV O
active ADJ O
precursor NOUN O
of ADP O
myeloperoxidase NOUN B-LF
( PUNCT O
MPO PROPN B-AC
) PUNCT O
, PUNCT O
is AUX O
known VERB O
to PART O
be AUX O
secreted VERB O
from ADP O
cultured ADJ O
bone NOUN O
marrow NOUN O
and CCONJ O
promyelocytic ADJ O
leukemia NOUN O
cells NOUN O
, PUNCT O
but CCONJ O
evidence NOUN O
for ADP O
the DET O
presence NOUN O
of ADP O
pro NOUN B-AC
- NOUN B-AC
MPO PROPN B-AC
in ADP O
circulation NOUN O
is AUX O
lacking VERB O
. PUNCT O

HT PROPN B-AC
: PUNCT O
hypertensive ADJ B-LF
. PUNCT O

By ADP O
reviewing VERB O
the DET O
slides NOUN O
through ADP O
H&E PROPN B-AC
and CCONJ O
CRP NOUN B-AC
immunostaining NOUN O
, PUNCT O
we PRON O
categorized VERB O
the DET O
patients NOUN O
into ADP O
( PUNCT O
1 NUM O
) PUNCT O
AAA NOUN B-AC
- PUNCT B-AC
high ADJ B-AC
mCRP NOUN B-AC
( PUNCT O
abdominal ADJ B-LF
aortic ADJ I-LF
aneurysm NOUN I-LF
with ADP O
high ADJ O
[ PUNCT O
moderate ADJ O
- PUNCT O
to ADP O
- PUNCT O
strong ADJ O
( PUNCT O
intensity NOUN O
: PUNCT O
2 X O
+ PUNCT O
, PUNCT O
3 X O
+ PUNCT O
) PUNCT O
] PUNCT O
and CCONJ O
diffuse ADJ O
CRP NOUN B-AC
immunopositivity NOUN O
) PUNCT O
, PUNCT O
( PUNCT O
2 X O
) PUNCT O
AAA NOUN B-AC
- PUNCT B-AC
low ADJ B-AC
mCRP NOUN B-AC
( PUNCT O
abdominal ADJ B-LF
aortic ADJ I-LF
aneurysm NOUN I-LF
with ADP O
low ADJ O
[ PUNCT O
negative ADJ O
- PUNCT O
to ADP O
- PUNCT O
weak ADJ O
( PUNCT O
intensity NOUN O
: PUNCT O
0 NUM O
, PUNCT O
1 NUM O
+ PUNCT O
) PUNCT O
] PUNCT O
, PUNCT O
focal ADJ O
, PUNCT O
and CCONJ O
junctional ADJ O
CRP NOUN B-AC
immunopositivity NOUN O
) PUNCT O
, PUNCT O
and CCONJ O
( PUNCT O
3 X O
) PUNCT O
AAD PROPN B-AC
groups NOUN O
. PUNCT O

Tumors NOUN O
, PUNCT O
in ADP O
turn NOUN O
, PUNCT O
inhibit VERB O
this DET O
anti ADJ O
- PUNCT O
tumor NOUN O
activity NOUN O
by ADP O
producing VERB O
immunosuppressive ADJ O
cytokines NOUN O
, PUNCT O
such ADJ O
as ADP O
IL-10 NOUN B-AC
and CCONJ O
TNF NOUN B-AC
- PUNCT O
β NOUN O
, PUNCT O
and CCONJ O
inducing VERB O
immunosuppressive ADJ O
cells NOUN O
, PUNCT O
such ADJ O
as ADP O
Tregs NOUN B-AC
, PUNCT O
tumor NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
macrophages NOUN I-LF
( PUNCT O
TAMs PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
myeloid NOUN B-LF
- PUNCT I-LF
derived VERB I-LF
suppressor NOUN I-LF
cells NOUN I-LF
( PUNCT O
MDSC PROPN B-AC
) PUNCT O
[ X O
21–24 NUM O
] PUNCT O
. PUNCT O

Yet CCONJ O
, PUNCT O
the DET O
diversity NOUN O
of ADP O
α NOUN O
- ADJ O
arrestin ADJ O
targets NOUN O
studied VERB O
is AUX O
restricted VERB O
to ADP O
a DET O
small ADJ O
subset NOUN O
of ADP O
plasma NOUN B-LF
membrane NOUN I-LF
( PUNCT O
PM PROPN B-AC
) PUNCT O
proteins NOUN O
. PUNCT O

The DET O
majority NOUN O
of ADP O
the DET O
HYPEST PROPN O
participants NOUN O
( PUNCT O
n NOUN O
= SYM O
1,482 NUM O
) PUNCT O
possess VERB O
a DET O
documented VERB O
history NOUN O
of ADP O
multiple ADJ O
systolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
( PUNCT O
SBP PROPN B-AC
) PUNCT O
and CCONJ O
diastolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
( PUNCT O
DBP PROPN B-AC
) PUNCT O
readings NOUN O
. PUNCT O

EGF PROPN O
, PUNCT O
epidermal ADJ O
growth NOUN O
factor NOUN O
; PUNCT O
EGFR PROPN B-AC
, PUNCT O
epidermal ADJ B-LF
growth NOUN I-LF
factor NOUN I-LF
receptor NOUN I-LF
; PUNCT O
FCHSD2 PROPN B-AC
, PUNCT O
FCH PROPN B-LF
/ SYM I-LF
F PROPN I-LF
- PUNCT I-LF
BAR PROPN I-LF
and CCONJ I-LF
Double PROPN I-LF
SH3 PROPN I-LF
Domain PROPN I-LF
- PUNCT I-LF
Containing PROPN I-LF
Protein PROPN I-LF
; PUNCT O
KD PROPN B-AC
, PUNCT O
knockdown NOUN B-LF
; PUNCT O
LAMP1 PROPN B-AC
, PUNCT O
lysosome NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
membrane NOUN I-LF
glycoprotein NOUN I-LF
1 NUM I-LF
; PUNCT O
siCtrl PROPN O
, PUNCT O
control NOUN O
siRNA NOUN B-AC
; PUNCT O
siRNA NOUN B-AC
, PUNCT O
small ADJ B-LF
interfering VERB I-LF
RNA NOUN I-LF
. PUNCT O

There PRON O
was VERB O
no DET O
evidence NOUN O
of ADP O
heterogeneity NOUN O
of ADP O
individual ADJ O
single ADJ B-LF
nucleotide NOUN I-LF
polymorphism NOUN I-LF
( PUNCT O
SNP PROPN B-AC
) PUNCT O
allele NOUN O
frequencies NOUN O
between ADP O
case NOUN O
groups NOUN O
or CCONJ O
control NOUN O
groups NOUN O
( PUNCT O
all PRON O
p NOUN O
> ADP O
0.01 NUM O
) PUNCT O
. PUNCT O

We PRON O
found VERB O
that SCONJ O
damaged VERB B-LF
DNA NOUN I-LF
binding VERB I-LF
protein NOUN I-LF
1 NUM I-LF
( PUNCT O
DDB1 PROPN B-AC
) PUNCT O
, PUNCT O
viral ADJ B-LF
protein NOUN I-LF
R NOUN I-LF
binding VERB I-LF
protein NOUN I-LF
( PUNCT O
VPRBP PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
cullin NOUN B-LF
4A NOUN I-LF
( PUNCT O
CUL4A)—components PROPN B-AC
of ADP O
a DET O
CUL4A PROPN B-AC
E3 PROPN O
ubiquitin NOUN O
ligase NOUN O
complex NOUN O
, PUNCT O
DDB1 PROPN B-AC
- PUNCT O
CUL4AVPRBP PROPN O
— PUNCT O
were AUX O
able ADJ O
to PART O
associate VERB O
with ADP O
Vpr PROPN B-AC
. PUNCT O

CKIP-1 PROPN O
loss NOUN O
of ADP O
function NOUN O
and CCONJ O
Smurf1 PROPN B-AC
overexpression NOUN B-LF
( PUNCT O
OE NOUN B-AC
) PUNCT O
each PRON O
result VERB O
in ADP O
reduced VERB O
BMP NOUN B-AC
signaling NOUN O
output NOUN O
and CCONJ O
reduced VERB O
paired VERB B-LF
box NOUN I-LF
7 NUM I-LF
( PUNCT O
Pax7 PROPN B-AC
) PUNCT O
expression NOUN O
in ADP O
the DET O
neural ADJ O
plate NOUN O
border NOUN O
domain NOUN O
. PUNCT O

We PRON O
report VERB O
2 NUM O
types NOUN O
of ADP O
analysis NOUN O
, PUNCT O
one NUM O
on ADP O
the DET O
intention NOUN B-LF
to ADP I-LF
treat VERB I-LF
( PUNCT O
ITT PROPN B-AC
) PUNCT O
population NOUN O
, PUNCT O
i.e. X O
, PUNCT O
all DET O
participants NOUN O
randomised VERB O
at ADP O
baseline NOUN O
, PUNCT O
and CCONJ O
the DET O
other ADJ O
on ADP O
the DET O
PP PROPN B-AC
population NOUN O
, PUNCT O
i.e. X O
, PUNCT O
including VERB O
only ADV O
those DET O
FG PROPN B-AC
participants NOUN O
who PRON O
adhered VERB O
to ADP O
the DET O
a DET O
priori X O
PP PROPN B-AC
attendance NOUN O
rate NOUN O
of ADP O
a DET O
minimum NOUN O
of ADP O
50 NUM O
% NOUN O
of ADP O
training NOUN O
sessions NOUN O
[ PUNCT O
16 NUM O
] PUNCT O
. PUNCT O

This DET O
prospective ADJ O
, PUNCT O
pragmatic ADJ O
randomized ADJ O
controlled ADJ O
trial NOUN O
compares VERB O
an DET O
intervention NOUN B-LF
group NOUN I-LF
( PUNCT O
IG PROPN B-AC
) PUNCT O
of ADP O
participants NOUN O
in ADP O
TBHC PROPN B-AC
to ADP O
a DET O
control NOUN B-LF
group NOUN I-LF
( PUNCT O
CG NOUN B-AC
) PUNCT O
without ADP O
TBHC PROPN B-AC
. PUNCT O
Endpoints NOUN O
were AUX O
assessed VERB O
two NUM O
years NOUN O
after ADP O
enrolment NOUN O
. PUNCT O

MNE PROPN O
, PUNCT O
mean ADJ O
normalised VERB O
expression NOUN O
; PUNCT O
ABW PROPN B-AC
, PUNCT O
Average ADJ B-LF
birth NOUN I-LF
weight NOUN I-LF
; PUNCT O
LBW PROPN B-AC
, PUNCT O
Low ADJ B-LF
birth NOUN I-LF
weight NOUN I-LF
; PUNCT O
* PUNCT O
P<0.05 NUM O
from ADP O
ABW PROPN B-AC
. PUNCT O

Endothelial ADJ B-LF
cells NOUN I-LF
( PUNCT O
ECs NOUN B-AC
) PUNCT O
[ X O
26 NUM O
] X O
, PUNCT O
leukocytes NOUN O
[ X O
27 NUM O
] X O
and CCONJ O
HSCs NOUN B-AC
[ X O
28 NUM O
] X O
are AUX O
reported VERB O
to ADP O
contribute VERB O
to ADP O
Hh NOUN B-AC
ligand NOUN O
production NOUN O
in ADP O
cirrhotic ADJ O
liver NOUN O
disease NOUN O
. PUNCT O

Randomisation NOUN O
was AUX O
at ADP O
a DET O
1:2:2 NUM O
allocation NOUN O
ratio NOUN O
to ADP O
( PUNCT O
i X O
) PUNCT O
image NOUN O
- PUNCT O
read VERB O
LBC PROPN B-AC
screening NOUN O
with ADP O
HPV PROPN B-AC
triage NOUN O
testing NOUN O
of ADP O
low ADJ O
- PUNCT O
grade NOUN O
cytology NOUN O
( PUNCT O
‘ PUNCT O
LBC PROPN B-AC
screening NOUN O
’ PUNCT O
) PUNCT O
; PUNCT O
( PUNCT O
ii X O
) PUNCT O
HPV PROPN B-AC
screening NOUN O
with ADP O
partial ADJ O
genotyping NOUN O
and CCONJ O
direct ADJ O
referral NOUN O
of ADP O
women NOUN O
with ADP O
detected VERB O
HPV16/18 NUM O
to ADP O
colposcopy NOUN O
and CCONJ O
with ADP O
LBC PROPN B-AC
triage NOUN O
for ADP O
other ADJ O
‘ PUNCT O
high ADJ O
risk NOUN O
’ PUNCT O
( PUNCT O
OHR PROPN O
) PUNCT O
oncogenic ADJ O
types NOUN O
( PUNCT O
‘ PUNCT O
HPV+LBC PROPN B-AC
triage NOUN O
’ PUNCT O
; PUNCT O
equivalent ADJ O
to ADP O
the DET O
new ADJ O
screening NOUN O
recommendations NOUN O
in ADP O
Australia PROPN O
) PUNCT O
; PUNCT O
or CCONJ O
( PUNCT O
iii X O
) PUNCT O
HPV PROPN B-AC
screening NOUN O
with ADP O
partial ADJ O
genotyping NOUN O
and CCONJ O
direct ADJ O
referral NOUN O
of ADP O
women NOUN O
with ADP O
detected VERB O
HPV16/18 NUM O
to ADP O
colposcopy NOUN O
and CCONJ O
with ADP O
dual ADJ B-LF
- PUNCT I-LF
stained VERB I-LF
cytology NOUN O
triage NOUN O
testing NOUN O
for ADP O
other ADJ O
oncogenic ADJ O
types NOUN O
( PUNCT O
‘ PUNCT O
HPV+DS PROPN B-AC
triage NOUN O
’ PUNCT O
) PUNCT O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
CQI PROPN B-AC
, PUNCT O
continuous ADJ B-LF
quality NOUN I-LF
improvement NOUN I-LF
; PUNCT O
RD NOUN O
, PUNCT O
risk NOUN O
difference NOUN O
; PUNCT O
RR NOUN B-AC
, PUNCT O
relative ADJ B-LF
risk NOUN I-LF
; PUNCT O
VL PROPN B-AC
, PUNCT O
HIV PROPN B-LF
viral ADJ I-LF
load NOUN I-LF

VPA NOUN B-AC
= PUNCT O
Vigorous ADJ B-LF
physical ADJ I-LF
activity NOUN I-LF
. PUNCT O

For ADP O
this PRON O
, PUNCT O
the DET O
ectodomain NOUN O
of ADP O
AMA1 PROPN B-AC
forms VERB O
adhesive ADJ O
interactions NOUN O
with ADP O
rhoptry PROPN B-LF
neck NOUN I-LF
protein NOUN I-LF
2 NUM I-LF
( PUNCT O
RON2 PROPN B-AC
) PUNCT O
, PUNCT O
another DET O
parasite NOUN O
protein NOUN O
, PUNCT O
which PRON O
is AUX O
secreted VERB O
from ADP O
a DET O
third ADJ O
set NOUN O
of ADP O
secretory ADJ O
organelles NOUN O
called VERB O
rhoptries NOUN O
into ADP O
the DET O
erythrocyte NOUN O
membrane NOUN O
[ X O
18–21 NUM O
] PUNCT O
. PUNCT O

Indeed ADV O
, PUNCT O
all DET O
patients NOUN O
receiving VERB O
animal NOUN O
polyclonal ADJ O
IgGs NOUN O
without ADP O
other ADJ O
immunosuppression NOUN B-LF
( PUNCT O
IS NOUN B-AC
) PUNCT O
develop VERB O
severe ADJ O
symptoms NOUN O
of ADP O
immune ADJ O
- PUNCT O
complex ADJ O
disease NOUN O
( PUNCT O
serum NOUN O
sickness NOUN O
disease NOUN O
) PUNCT O
[ PUNCT O
6 NUM O
] PUNCT O
. PUNCT O

GFP PROPN B-AC
- PUNCT O
α NOUN B-AC
- PUNCT B-AC
Ada PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
fused VERB O
with ADP O
α NOUN B-LF
- PUNCT I-LF
Adaptin PROPN I-LF
; PUNCT O
imac NOUN B-AC
, PUNCT O
immaculate ADJ B-LF
connections NOUN I-LF
; PUNCT O
RNAi NOUN B-AC
, PUNCT O
RNA NOUN B-LF
interference NOUN I-LF
; PUNCT O
Venus PROPN O
- PUNCT O
Prd1 PROPN O
, PUNCT O
Venus PROPN O
- PUNCT O
Pruning NOUN O
defect NOUN O
1 NUM O
. PUNCT O

We PRON O
used VERB O
mathematical ADJ O
modeling NOUN O
to ADP O
predict VERB O
the DET O
impact NOUN O
of ADP O
the DET O
scale NOUN O
- PUNCT O
up NOUN O
of ADP O
DTG PROPN B-AC
- PUNCT O
based VERB O
ART PROPN B-AC
on ADP O
NNRTI PROPN B-AC
pretreatment NOUN B-LF
drug NOUN I-LF
resistance NOUN I-LF
( PUNCT O
PDR NOUN B-AC
) PUNCT O
in ADP O
South PROPN O
Africa PROPN O
, PUNCT O
2020 NUM O
to ADP O
2040 NUM O
. PUNCT O

chaperone NOUN B-LF
protein NOUN I-LF
DnaK PROPN I-LF

Bioassay NOUN O
of ADP O
the DET O
field NOUN O
population NOUN O
of ADP O
N. PROPN O
lugens PROPN O
collected VERB O
from ADP O
Guangxi PROPN O
, PUNCT O
China PROPN O
( PUNCT O
called VERB O
GX PROPN O
- PUNCT O
P PROPN O
) PUNCT O
in ADP O
2011 NUM O
showed VERB O
that SCONJ O
it PRON O
had VERB O
a DET O
50 NUM B-LF
% NOUN I-LF
lethal ADJ I-LF
concentration NOUN I-LF
( PUNCT O
LC50 NUM B-AC
) PUNCT O
of ADP O
30.98 NUM O
mg NOUN O
/ SYM O
l NOUN O
( PUNCT O
S1 PROPN O
Table PROPN O
) PUNCT O
. PUNCT O

The DET O
antioxidant ADJ O
activities NOUN O
of ADP O
the DET O
extracts NOUN O
were AUX O
evaluated VERB O
using VERB O
assays NOUN O
to PART O
assess VERB O
DPPH NOUN B-AC
( PUNCT O
1,1 NUM B-LF
- PUNCT I-LF
diphenyl-2 NOUN I-LF
- PUNCT I-LF
picryl NOUN I-LF
- PUNCT I-LF
hydrazyl NOUN I-LF
) PUNCT O
and CCONJ O
hydroxyl NOUN O
radical NOUN O
scavenging NOUN O
activities NOUN O
, PUNCT O
metal NOUN O
- PUNCT O
chelating VERB O
activity NOUN O
and CCONJ O
reducing VERB O
power NOUN O
of ADP O
the DET O
extracts NOUN O
. PUNCT O

RBPs NOUN B-AC
are AUX O
members NOUN O
of ADP O
the DET O
intracellular ADJ O
lipid NOUN O
binding VERB O
proteins NOUN O
that PRON O
display VERB O
a DET O
high ADJ O
binding VERB O
affinity NOUN O
to ADP O
all PRON B-LF
- NOUN I-LF
trans NOUN I-LF
- NOUN I-LF
retinol NOUN I-LF
( PUNCT O
ROL PROPN B-AC
) PUNCT O
[ PUNCT O
12–14 NUM O
] PUNCT O
. PUNCT O

Phosphoglycerate NOUN B-LF
kinase NOUN I-LF
1 NUM O
( PUNCT O
PGK1 PROPN B-AC
) PUNCT O
catalyzes VERB O
the DET O
reversible ADJ O
transfer NOUN O
of ADP O
a DET O
phosphoryl NOUN O
group NOUN O
from ADP O
1 NUM B-LF
, PUNCT I-LF
3 NUM I-LF
- PUNCT I-LF
bisphosphoglycerate NOUN I-LF
( PUNCT O
1 NUM B-AC
, PUNCT B-AC
3 NUM B-AC
- PUNCT B-AC
BPG NOUN B-AC
) PUNCT O
to ADP O
ADP PROPN O
, PUNCT O
producing VERB O
3 NUM B-LF
- PUNCT I-LF
phosphoglycerate NOUN I-LF
( PUNCT O
3 NUM B-AC
- PUNCT B-AC
PG NOUN B-AC
) PUNCT O
and CCONJ O
ATP PROPN O
. PUNCT O
PGK1 PROPN B-AC
plays VERB O
a DET O
key ADJ O
role NOUN O
in ADP O
coordinating VERB O
glycolytic ADJ O
energy NOUN O
production NOUN O
with ADP O
one NUM O
- PUNCT O
carbon NOUN O
metabolism NOUN O
, PUNCT O
serine NOUN O
biosynthesis NOUN O
, PUNCT O
and CCONJ O
cellular ADJ O
redox NOUN O
regulation NOUN O
. PUNCT O

In ADP O
the DET O
mothers NOUN O
, PUNCT O
earlier ADJ O
menarche NOUN O
was AUX O
associated VERB O
with ADP O
shorter ADJ O
adult NOUN O
height NOUN O
( PUNCT O
by ADP O
0.64 NUM O
cm NOUN O
/ SYM O
y NOUN O
) PUNCT O
, PUNCT O
increased VERB O
weight NOUN O
( PUNCT O
0.92 NUM O
kg NOUN O
/ SYM O
y NOUN O
) PUNCT O
, PUNCT O
and CCONJ O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT O
BMI NOUN B-AC
, PUNCT O
0.51 NUM O
kg NOUN O
/ SYM O
m2 NOUN O
/ SYM O
y NOUN O
; PUNCT O
all PRON O
p NOUN O
< ADP O
0.001 NUM O
) PUNCT O
. PUNCT O

It PRON O
accounts VERB O
for ADP O
a DET O
total NOUN O
of ADP O
1,010 NUM O
open ADJ B-LF
reading NOUN I-LF
frames NOUN I-LF
( PUNCT O
ORFs NOUN B-AC
) PUNCT O
, PUNCT O
or CCONJ O
about ADV O
one PRON O
- PUNCT O
third NOUN O
of ADP O
the DET O
functionally ADV O
assigned VERB O
ORFs NOUN B-AC
. PUNCT O
It PRON O
is AUX O
composed VERB O
of ADP O
906 NUM O
metabolic ADJ O
ORFs NOUN B-AC
enabling VERB O
932 NUM O
biochemical ADJ O
reactions NOUN O
( PUNCT O
including VERB O
transporters NOUN O
) PUNCT O
among ADP O
625 NUM O
metabolites NOUN O
, PUNCT O
as ADP O
well ADV O
as ADP O
104 NUM O
TFs NOUN B-AC
regulating VERB O
the DET O
expression NOUN O
of ADP O
479 NUM O
of ADP O
the DET O
1,010 NUM O
ORFs NOUN B-AC
. PUNCT O
The DET O
reconstructed VERB O
TRN PROPN B-AC
is AUX O
implemented VERB O
with ADP O
a DET O
Boolean ADJ O
logic NOUN O
formalism NOUN O
, PUNCT O
which PRON O
allows VERB O
one PRON O
to PART O
compute VERB O
the DET O
“ PUNCT O
off ADV O
/ SYM O
on ADP O
” PUNCT O
expression NOUN O
status NOUN O
of ADP O
genes NOUN O
based VERB O
on ADP O
the DET O
“ PUNCT O
inactive ADJ O
/ SYM O
active ADJ O
” PUNCT O
state NOUN O
of ADP O
particular ADJ O
TFs NOUN B-AC
and/or CCONJ O
the DET O
absence NOUN O
/ SYM O
presence NOUN O
of ADP O
particular ADJ O
environmental ADJ O
constituents NOUN O
. PUNCT O

Polymerase NOUN B-LF
chain NOUN I-LF
reaction NOUN I-LF
( PUNCT O
PCR PROPN B-AC
) PUNCT O
testing NOUN O
has AUX O
identified VERB O
many ADJ O
different ADJ O
viral ADJ O
causes NOUN O
of ADP O
pediatric ADJ O
SARI PROPN B-AC
[ X O
3–6 NUM O
] PUNCT O
. PUNCT O

SHORT PROPN B-LF
- PUNCT I-LF
ROOT NOUN I-LF
( PUNCT O
SHR PROPN B-AC
) PUNCT O
is AUX O
a DET O
putative ADJ O
transcription NOUN O
factor NOUN O
of ADP O
the DET O
GRAS PROPN O
family NOUN O
and CCONJ O
is AUX O
a DET O
key ADJ O
component NOUN O
in ADP O
a DET O
developmental ADJ O
pathway NOUN O
regulating VERB O
the DET O
specification NOUN O
of ADP O
the DET O
root NOUN O
stem NOUN O
cell NOUN O
niche NOUN O
as ADP O
well ADV O
as ADP O
the DET O
radial ADJ O
patterning NOUN O
of ADP O
the DET O
root NOUN O
in ADP O
Arabidopsis PROPN O
[ PUNCT O
6 NUM O
– SYM O
8 NUM O
] PUNCT O
. PUNCT O

Then ADV O
we PRON O
measured VERB O
the DET O
evoked VERB O
EPSCs NOUN O
( PUNCT O
eEPSCs NOUN B-AC
) PUNCT O
in ADP O
pyramidal ADJ O
neurons NOUN O
( PUNCT O
Fig PROPN O
2H NUM O
) PUNCT O
. PUNCT O
We PRON O
confirmed VERB O
that SCONJ O
the DET O
evoked VERB O
currents NOUN O
were AUX O
truly ADV O
AMPAR- NOUN B-AC
and CCONJ O
N NOUN B-LF
- PUNCT I-LF
methyl NOUN I-LF
- PUNCT I-LF
D NOUN I-LF
- PUNCT I-LF
aspartic ADJ I-LF
acid NOUN I-LF
receptor NOUN I-LF
( PUNCT O
NMDAR)-mediated PROPN B-AC
currents NOUN O
by ADP O
using VERB O
AMPAR- NOUN B-AC
and CCONJ O
NMDAR PROPN B-AC
- PUNCT O
specific ADJ O
antagonists NOUN O
6 NUM B-LF
- PUNCT I-LF
cyano-7 NOUN I-LF
- PUNCT I-LF
nitroquinoxaline-2,3 NOUN I-LF
- PUNCT I-LF
dione NOUN I-LF
( PUNCT O
CNQX PROPN B-AC
) PUNCT O
and CCONJ O
DL-2 PROPN B-LF
- PUNCT I-LF
Amino-5 NOUN I-LF
- PUNCT I-LF
phosphonopentanoic NOUN I-LF
acid NOUN I-LF
( PUNCT O
DL PROPN B-AC
- PUNCT B-AC
AP5 PROPN B-AC
) PUNCT O
, PUNCT O
respectively ADV O
( PUNCT O
S5A PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

The DET O
thickness NOUN O
of ADP O
retinal ADJ O
layers NOUN O
{ PUNCT O
retinal ADJ B-LF
nerve NOUN I-LF
fiber NOUN I-LF
layer NOUN I-LF
( PUNCT O
RNFL PROPN B-AC
) PUNCT O
, PUNCT O
ganglion NOUN B-LF
cell NOUN I-LF
layer NOUN I-LF
plus CCONJ I-LF
inner ADJ I-LF
plexiform ADJ I-LF
layer NOUN I-LF
( PUNCT O
GCLIPL PROPN B-AC
) PUNCT O
, PUNCT O
RNFL PROPN B-AC
plus CCONJ O
GCLIPL PROPN B-AC
( PUNCT O
ganglion NOUN B-LF
cell NOUN I-LF
complex NOUN I-LF
, PUNCT O
GCC PROPN B-AC
) PUNCT O
, PUNCT O
total ADJ O
retina NOUN O
, PUNCT O
total ADJ O
retina NOUN O
minus CCONJ O
GCC PROPN B-AC
( PUNCT O
outer ADJ O
retina NOUN O
) PUNCT O
} PUNCT O
were AUX O
measured VERB O
by ADP O
macular ADJ O
scans NOUN O
( PUNCT O
RS-3000 PROPN O
, PUNCT O
NIDEK PROPN O
) PUNCT O
in ADP O
202 NUM O
eyes NOUN O
of ADP O
202 NUM O
normal ADJ O
Asian ADJ O
subjects NOUN O
aged VERB O
20 NUM O
to PART O
60 NUM O
years NOUN O
. PUNCT O

We PRON O
and CCONJ O
others NOUN O
have AUX O
used VERB O
human ADJ B-LF
pluripotent ADJ I-LF
stem NOUN I-LF
cells NOUN I-LF
( PUNCT O
hPSCs PROPN B-AC
) PUNCT O
to PART O
demonstrate VERB O
that SCONJ O
BMP4 PROPN B-AC
treatment NOUN O
of ADP O
geometrically ADV O
confined VERB O
hPSC PROPN B-AC
colonies NOUN O
recapitulate VERB O
aspects NOUN O
of ADP O
human ADJ O
peri NOUN O
- NOUN O
gastrulation NOUN O
– PUNCT O
like ADJ O
organized VERB O
fate NOUN O
patterning NOUN O
[ PUNCT O
24–26 NUM O
] PUNCT O
. PUNCT O

c X O
RA NOUN B-AC
/ SYM O
CLA NOUN B-AC
, PUNCT O
Rumenic ADJ B-LF
acid NOUN I-LF
/ SYM O
Conjugated VERB B-LF
linoleic ADJ I-LF
acid NOUN I-LF
. PUNCT O

The DET O
mean ADJ O
age NOUN O
of ADP O
mothers NOUN O
when SCONJ O
the DET O
study NOUN O
children NOUN O
were AUX O
born VERB O
was AUX O
29.6 NUM O
years NOUN O
( PUNCT O
standard ADJ B-LF
deviation NOUN I-LF
[ PUNCT O
SD NOUN B-AC
] PUNCT O
, PUNCT O
5.7 NUM O
) PUNCT O
and CCONJ O
the DET O
median ADJ O
age NOUN O
was AUX O
30 NUM O
years NOUN O
( PUNCT O
interquartile ADJ B-LF
range NOUN I-LF
[ PUNCT O
IQR NOUN B-AC
] PUNCT O
, PUNCT O
26–34 NUM O
; PUNCT O
range NOUN O
, PUNCT O
13–56 NUM O
) PUNCT O
. PUNCT O

CD4+CD25+FoxP3 NOUN O
+ NOUN O
IL-10 NOUN O
– VERB O
producing VERB O
natural ADJ O
T NOUN B-LF
regulatory ADJ I-LF
cells NOUN I-LF
( PUNCT O
Tregs NOUN B-AC
) PUNCT O
have AUX O
been AUX O
elegantly ADV O
shown VERB O
to PART O
control VERB O
parasite NOUN O
survival NOUN O
[ PUNCT O
44,45 NUM O
] PUNCT O
. PUNCT O

More ADJ O
than ADP O
15 NUM O
% NOUN O
of ADP O
patients NOUN O
presenting VERB O
with ADP O
mixed ADJ O
infection NOUN O
of ADP O
P. PROPN O
falciparum NOUN O
and CCONJ O
P. PROPN O
vivax NOUN O
had VERB O
P. PROPN O
vivax NOUN O
parasitaemia NOUN O
within ADP O
42 NUM O
days NOUN O
, PUNCT O
supporting VERB O
the DET O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT O
WHO PROPN B-AC
) PUNCT O
recommendation NOUN O
for ADP O
the DET O
use NOUN O
of ADP O
primaquine NOUN O
radical NOUN O
cure NOUN O
in ADP O
these DET O
patients NOUN O
. PUNCT O

A X O
) PUNCT O
LC3II PROPN O
B X O
) PUNCT O
LC3I PROPN O
protein NOUN O
content NOUN O
, PUNCT O
C X O
) PUNCT O
LC3II PROPN O
/ SYM O
LC3I PROPN O
Ratio NOUN O
and CCONJ O
D X O
) PUNCT O
P62 NOUN O
protein NOUN O
content NOUN O
from ADP O
PGC-1α NOUN B-AC
knockout NOUN B-LF
( PUNCT O
KO PROPN B-AC
) PUNCT O
and CCONJ O
littermate NOUN O
wildtype NOUN B-LF
( PUNCT O
WT PROPN B-AC
) PUNCT O
control NOUN O
mice NOUN O
at ADP O
rest NOUN O
( PUNCT O
REST NOUN B-AC
) PUNCT O
, PUNCT O
3h NUM O
and CCONJ O
6h NUM O
after ADP O
a DET O
single ADJ O
treadmill NOUN O
exercise NOUN O
bout NOUN O
at ADP O
either CCONJ O
low ADJ O
intensity NOUN O
( PUNCT O
LI PROPN B-AC
) PUNCT O
or CCONJ O
moderate ADJ O
intensity NOUN O
( PUNCT O
MI PROPN B-AC
) PUNCT O
. PUNCT O
Values NOUN O
are AUX O
mean ADJ O
±SE NOUN O
, PUNCT O
n NOUN O
= SYM O
8 NUM O
. PUNCT O
* PUNCT O
Significantly ADV O
different ADJ O
from ADP O
REST NOUN B-AC
within ADP O
given VERB O
genotype NOUN O
( PUNCT O
p<0.05 NUM O
) PUNCT O
. PUNCT O
¤ PUNCT O
Significantly ADV O
different ADJ O
from ADP O
LI PROPN B-AC
within ADP O
given VERB O
genotype NOUN O
( PUNCT O
p<0.05 NUM O
) PUNCT O
. PUNCT O
# PUNCT O
Significantly ADV O
different ADJ O
from ADP O
WT PROPN B-AC
within ADP O
given VERB O
group NOUN O
( PUNCT O
p<0.05 NUM O
) PUNCT O
. PUNCT O

Flow NOUN O
cytometry NOUN O
analysis NOUN O
of ADP O
uterine ADJ O
implantation NOUN O
sites NOUN O
following VERB O
removal NOUN O
of ADP O
the DET O
placenta NOUN O
/ SYM O
embryo NOUN O
demonstrated VERB O
that SCONJ O
the DET O
percentage NOUN O
of ADP O
BM PROPN B-AC
- NOUN O
derived VERB O
GFP+ PROPN B-AC
cells NOUN O
in ADP O
the DET O
implantation NOUN O
site NOUN O
increased VERB O
as ADP O
pregnancy NOUN O
progressed VERB O
to ADP O
mid NOUN O
- NOUN O
gestation NOUN O
; PUNCT O
it PRON O
increased VERB O
significantly ADV O
on ADP O
the DET O
day NOUN O
of ADP O
implantation NOUN O
( PUNCT O
E5.5 NUM O
) PUNCT O
( PUNCT O
15.8 NUM O
% NOUN O
) PUNCT O
as ADP O
compared VERB O
with ADP O
the DET O
nonpregnant ADJ O
state NOUN O
( PUNCT O
9.2 NUM O
% NOUN O
) PUNCT O
, PUNCT O
peaking VERB O
on ADP O
E9.5 NUM O
( PUNCT O
24.1 NUM O
% NOUN O
) PUNCT O
, PUNCT O
followed VERB O
by ADP O
a DET O
gradual ADJ O
decrease NOUN O
on ADP O
E13.5 NOUN O
( PUNCT O
16.7 NUM O
% NOUN O
) PUNCT O
and CCONJ O
peripartum NOUN O
( PUNCT O
E17.5 NUM O
) PUNCT O
( PUNCT O
13.1 NUM O
% NOUN O
) PUNCT O
( PUNCT O
Fig PROPN O
1D NUM O
and CCONJ O
1F NOUN O
) PUNCT O
. PUNCT O
As SCONJ O
the DET O
observed VERB O
increase NOUN O
in ADP O
GFP+ PROPN B-AC
cells NOUN O
in ADP O
the DET O
decidua NOUN O
during ADP O
pregnancy NOUN O
could AUX O
be AUX O
due ADJ O
to ADP O
local ADJ O
proliferation NOUN O
of ADP O
BMDCs NOUN B-AC
and CCONJ O
not PART O
only ADV O
to ADP O
increased VERB O
recruitment NOUN O
, PUNCT O
we PRON O
assessed VERB O
cell NOUN O
proliferation NOUN O
using VERB O
proliferating VERB B-LF
cell NOUN I-LF
nuclear ADJ I-LF
antigen NOUN I-LF
( PUNCT O
PCNA PROPN B-AC
) PUNCT O
staining NOUN O
. PUNCT O

The DET O
diagnosis NOUN O
of ADP O
sepsis NOUN O
was AUX O
made VERB O
according VERB O
to ADP O
the DET O
criteria NOUN O
of ADP O
the DET O
American PROPN B-LF
College PROPN I-LF
of ADP I-LF
Chest PROPN I-LF
Physicians PROPN I-LF
/ SYM O
Society PROPN B-LF
of ADP I-LF
Critical PROPN I-LF
Care PROPN I-LF
Medicine PROPN I-LF
( PUNCT O
ACCP PROPN B-AC
- PUNCT O
SCCM PROPN B-AC
) PUNCT O
consensus NOUN O
conference NOUN O
committee NOUN O
[ PUNCT O
15 NUM O
, PUNCT O
16 NUM O
] PUNCT O
and CCONJ O
MOF PROPN B-AC
was AUX O
defined VERB O
as ADP O
simultaneous ADJ O
failure NOUN O
of ADP O
least ADV O
two NUM O
organs NOUN O
. PUNCT O

New ADJ O
appearance NOUN O
of ADP O
contrast NOUN B-LF
enhancement NOUN I-LF
( PUNCT O
CE NOUN B-AC
) PUNCT O
in ADP O
magnetic ADJ B-LF
resonance NOUN I-LF
imaging NOUN I-LF
( PUNCT O
MRI PROPN B-AC
) PUNCT O
follow NOUN O
- PUNCT O
up NOUN O
is AUX O
currently ADV O
the DET O
established VERB O
imaging NOUN O
feature NOUN O
related VERB O
to ADP O
MT NOUN B-AC
[ X O
7,8 NUM O
] PUNCT O
, PUNCT O
especially ADV O
if SCONJ O
no DET O
recent ADJ O
therapy NOUN O
has AUX O
been AUX O
administered VERB O
. PUNCT O

Data NOUN O
are AUX O
indicated VERB O
as ADP O
mean ADJ O
concentrations NOUN O
of ADP O
biogenic ADJ O
amines NOUN O
( PUNCT O
dopamine NOUN B-LF
, PUNCT O
DA PROPN B-AC
; PUNCT O
norepinephrine NOUN B-LF
, PUNCT O
NE PROPN B-AC
; PUNCT O
5 NUM O
- PUNCT O
hydroxytryptamine NOUN O
, PUNCT O
5 NUM B-AC
- PUNCT B-AC
HT NOUN B-AC
) PUNCT O
and CCONJ O
metabolites NOUN O
( PUNCT O
3 NUM B-LF
- PUNCT I-LF
4 NUM I-LF
- PUNCT I-LF
Dihydroxyphenylacetic NOUN I-LF
acid NOUN I-LF
, PUNCT O
DOPAC PROPN B-AC
; PUNCT O
homovanillic ADJ B-LF
acid NOUN I-LF
, PUNCT O
HVA PROPN B-AC
; PUNCT O
3 NUM B-LF
- PUNCT I-LF
methoxy-4 NOUN I-LF
hydroxyphenylethyleneglycol NOUN I-LF
, PUNCT O
MHPG PROPN B-AC
; PUNCT O
5 NUM O
- PUNCT O
hydroxyindoleacetic ADJ O
acid NOUN O
, PUNCT O
5 NUM B-AC
- PUNCT B-AC
HIAA NOUN B-AC
) PUNCT O
±ES NOUN O
. PUNCT O

In ADP O
order NOUN O
to PART O
improve VERB O
the DET O
contrast NOUN O
of ADP O
the DET O
soft ADJ O
tissues NOUN O
, PUNCT O
the DET O
sample NOUN O
was AUX O
stained VERB O
with ADP O
0.3 NUM O
% NOUN O
phosphotungstic ADJ B-LF
acid NOUN I-LF
solution NOUN O
( PUNCT O
PTA PROPN B-AC
; PUNCT O
Sigma PROPN O
Aldrich PROPN O
) PUNCT O
in ADP O
70 NUM O
% NOUN O
ethanol NOUN O
for ADP O
6.5 NUM O
days NOUN O
. PUNCT O

In ADP O
Drosophila PROPN O
, PUNCT O
the DET O
Hh PROPN O
signal NOUN O
is AUX O
transduced VERB O
through ADP O
a DET O
receptor NOUN O
system NOUN O
at ADP O
the DET O
plasma NOUN O
membrane NOUN O
, PUNCT O
which PRON O
includes VERB O
the DET O
receptor NOUN O
complex NOUN O
Patched PROPN B-LF
- PUNCT I-LF
Interference PROPN I-LF
Hh PROPN I-LF
( PUNCT O
Ptc NOUN B-AC
- PUNCT B-AC
Ihog PROPN B-AC
) PUNCT O
and CCONJ O
the DET O
signal NOUN O
transducer NOUN O
Smo PROPN B-AC
[ X O
4–6 NUM O
] PUNCT O
. PUNCT O

PCa NOUN B-AC
, PUNCT O
prostate NOUN B-LF
cancer NOUN I-LF
. PUNCT O

Active ADJ O
Case NOUN O
Finding NOUN O
for ADP O
Tuberculosis NOUN B-LF
through ADP O
TOUCH NOUN O
Agents NOUN O
in ADP O
Selected VERB O
High ADJ O
TB NOUN B-AC
Burden NOUN O
Wards NOUN O
of ADP O
Kolkata PROPN O
, PUNCT O
India PROPN O
: PUNCT O
A DET O
Mixed ADJ O
Methods NOUN O
Study NOUN O
on ADP O
Outcomes NOUN O
and CCONJ O
Implementation NOUN O
Challenges NOUN O
. PUNCT O

The DET O
59 NUM O
microorganisms NOUN O
were AUX O
automatically ADV O
mapped VERB O
between ADP O
datasets NOUN O
of ADP O
MKD PROPN B-AC
and CCONJ O
Pfam PROPN B-AC
using VERB O
the DET O
National PROPN B-LF
Center PROPN I-LF
for ADP I-LF
Biotechnology PROPN I-LF
Information PROPN I-LF
's PART O
( PUNCT O
NCBI PROPN B-AC
) PUNCT O
taxons NOUN O
as ADP O
a DET O
reference NOUN O
, PUNCT O
followed VERB O
by ADP O
manual ADJ O
examination NOUN O
by ADP O
experts NOUN O
( PUNCT O
Figure PROPN O
1 NUM O
) PUNCT O
. PUNCT O

For ADP O
example NOUN O
, PUNCT O
P63 PROPN O
regulates VERB O
growth NOUN O
, PUNCT O
invasion NOUN O
and CCONJ O
metastasis NOUN O
of ADP O
esophageal ADJ B-LF
squamous ADJ I-LF
cell NOUN I-LF
carcinoma NOUN I-LF
( PUNCT O
ESCC PROPN B-AC
) PUNCT O
cells NOUN O
[ PUNCT O
7 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
Sox2 PROPN O
functions VERB O
as ADP O
an DET O
amplified ADJ O
lineage NOUN O
- PUNCT O
survival NOUN O
oncogene NOUN O
in ADP O
ESCC PROPN B-AC
[ PUNCT O
8 NUM O
] PUNCT O
. PUNCT O

PCR NOUN B-AC
, PUNCT O
polymerase NOUN B-LF
chain NOUN I-LF
reaction NOUN I-LF
. PUNCT O

We PRON O
calculated VERB O
the DET O
mean ADJ O
BMI NOUN B-AC
, PUNCT O
mean ADJ O
waist NOUN B-LF
circumference NOUN I-LF
( PUNCT O
WC PROPN B-AC
) PUNCT O
and CCONJ O
odds NOUN B-LF
ratios NOUN I-LF
( PUNCT O
ORs NOUN B-AC
) PUNCT O
for ADP O
BMI NOUN B-AC
comparing VERB O
the DET O
lowest ADJ O
life NOUN O
course NOUN O
SES PROPN B-AC
category NOUN O
with ADP O
the DET O
highest ADJ O
life NOUN O
course NOUN O
SES PROPN B-AC
category NOUN O
for ADP O
each DET O
study NOUN O
. PUNCT O

X NOUN O
- NOUN O
ray NOUN O
diffraction NOUN O
studies NOUN O
guided VERB O
by ADP O
nuclear ADJ B-LF
magnetic ADJ I-LF
resonance NOUN I-LF
( PUNCT O
NMR PROPN B-AC
) PUNCT O
experiments NOUN O
reveal VERB O
the DET O
crystal NOUN O
structures NOUN O
of ADP O
the DET O
Munc13–1 PROPN O
C NOUN O
2A NOUN O
- NOUN O
domain NOUN O
homodimer NOUN O
and CCONJ O
the DET O
Munc13–1 PROPN O
C NOUN O
2A NOUN O
- NOUN O
domain NOUN O
/ SYM O
RIM PROPN O
ZF PROPN B-AC
heterodimer NOUN O
at ADP O
1.44 NUM O
Å NOUN O
and CCONJ O
1.78 NUM O
Å NOUN O
resolution NOUN O
, PUNCT O
respectively ADV O
. PUNCT O

In ADP O
the DET O
first ADJ O
stage NOUN O
, PUNCT O
we PRON O
analyzed VERB O
Y PROPN B-LF
- ADJ I-LF
chromosome NOUN I-LF
short ADJ I-LF
tandem NOUN I-LF
repeat NOUN I-LF
( PUNCT O
Y PROPN B-AC
- ADJ B-AC
STR PROPN B-AC
) PUNCT O
and CCONJ O
mtDNA NOUN B-AC
hyper ADJ B-LF
variable NOUN I-LF
segment NOUN I-LF
1 NUM I-LF
( PUNCT O
HVS1 NOUN B-AC
) PUNCT O
sequence NOUN O
data NOUN O
from ADP O
two NUM O
groups NOUN O
of ADP O
Indian ADJ O
tribes NOUN O
, PUNCT O
comprised VERB O
of ADP O
five NUM O
populations NOUN O
each PRON O
, PUNCT O
belonging VERB O
to ADP O
a DET O
broad ADJ O
linguistic ADJ O
family NOUN O
and CCONJ O
with ADP O
similar ADJ O
socio ADJ O
- ADJ O
economic ADJ O
status NOUN O
. PUNCT O

Small ADJ B-LF
for ADP I-LF
gestational ADJ I-LF
age NOUN I-LF
( PUNCT O
SGA PROPN B-AC
) PUNCT O
was AUX O
defined VERB O
as ADP O
a DET O
BW NOUN B-AC
less ADJ O
than ADP O
the DET O
10th ADJ O
percentile NOUN O
of ADP O
the DET O
standard ADJ O
BW NOUN B-AC
for ADP O
gestational ADJ O
age NOUN O
published VERB O
by ADP O
the DET O
Japan PROPN O
Pediatric PROPN O
Society PROPN O
[ PUNCT O
12 NUM O
] PUNCT O
. PUNCT O

CI NOUN B-AC
: PUNCT O
Confidence NOUN B-LF
interval NOUN I-LF

KCMC PROPN B-AC
= PUNCT O
Kilimanjaro PROPN B-LF
Christian PROPN I-LF
Medical PROPN I-LF
Center PROPN I-LF
. PUNCT O
Data NOUN O
were AUX O
analyzed VERB O
with ADP O
Pearson PROPN O
Chi PROPN O
Square PROPN O
and CCONJ O
student NOUN O
t NOUN O
tests NOUN O
where SCONJ O
appropriate ADJ O
. PUNCT O

The DET O
genotype NOUN O
AA NOUN O
of ADP O
the DET O
rs4730153 NOUN O
SNP NOUN O
was AUX O
significantly ADV O
associated VERB O
with ADP O
fasting VERB O
glucose NOUN O
, PUNCT O
fasting VERB O
insulin NOUN O
and CCONJ O
HOMA NOUN B-AC
- PUNCT B-AC
IR PROPN B-AC
( PUNCT O
Homeostasis NOUN O
model NOUN O
assessment NOUN O
- PUNCT O
insulin NOUN B-LF
resistance NOUN I-LF
) PUNCT O
after ADP O
adjustment NOUN O
for ADP O
gender NOUN O
, PUNCT O
age NOUN O
, PUNCT O
BMI NOUN B-AC
and CCONJ O
waist NOUN O
circumference NOUN O
. PUNCT O

PER NOUN B-AC
oscillations NOUN O
in ADP O
the DET O
fifth ADJ O
s NOUN B-AC
- PUNCT B-AC
LNv NOUN B-AC
were AUX O
therefore ADV O
expected VERB O
to PART O
peak VERB O
around ADP O
circadian ADJ O
time NOUN O
( PUNCT O
CT)57–58 NUM O
in ADP O
the DET O
third ADJ O
day NOUN O
of ADP O
LL PROPN B-AC
if SCONJ O
the DET O
EO NOUN B-AC
oscillator NOUN O
runs VERB O
with ADP O
a DET O
22.8 NUM O
- PUNCT O
h NOUN O
period NOUN B-LF
( PUNCT O
see VERB O
Table PROPN O
2 NUM O
) PUNCT O
. PUNCT O

A DET O
fraction NOUN O
of ADP O
EpiCs PROPN B-AC
undergo VERB O
epithelial ADJ B-LF
- ADJ I-LF
to ADP I-LF
- ADJ I-LF
mesenchymal ADJ I-LF
transition NOUN I-LF
( PUNCT O
EMT PROPN B-AC
) PUNCT O
, PUNCT O
giving VERB O
rise NOUN O
to ADP O
epicardial ADJ B-LF
- ADJ I-LF
derived VERB I-LF
cells NOUN I-LF
( PUNCT O
EPDCs PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
migrate VERB O
into ADP O
the DET O
myocardium NOUN O
and CCONJ O
generate VERB O
peri ADJ O
- ADJ O
vascular ADJ O
smooth ADJ B-LF
muscle NOUN I-LF
cells NOUN I-LF
( PUNCT O
SMCs PROPN B-AC
) PUNCT O
[ X O
4 NUM O
] PUNCT O
and CCONJ O
fibroblasts NOUN B-LF
( PUNCT O
FBs NOUN B-AC
) PUNCT O
[ X O
5,6 NUM O
] PUNCT O
. PUNCT O

LAIV PROPN B-AC
, PUNCT O
live ADJ B-LF
attenuated VERB I-LF
influenza NOUN I-LF
vaccine NOUN I-LF
. PUNCT O

NK PROPN B-AC
, PUNCT O
natural ADJ B-LF
killer NOUN I-LF
; PUNCT O
PBMC PROPN B-AC
, PUNCT O
peripheral ADJ B-LF
blood NOUN I-LF
mononuclear ADJ I-LF
cell NOUN I-LF
. PUNCT O

The DET O
dashed ADJ O
line NOUN O
represents VERB O
the DET O
level NOUN O
of ADP O
inoculation NOUN O
at ADP O
t NOUN O
= SYM O
0 NUM O
h NOUN O
( PUNCT O
104 NUM O
CFUs NOUN B-AC
per ADP O
mL NOUN O
) PUNCT O
. PUNCT O
ApWJL PROPN B-AC
, PUNCT O
A. NOUN O
pomorumWJL NOUN O
; PUNCT O
CFU PROPN B-AC
, PUNCT O
colony NOUN B-LF
- PUNCT I-LF
forming VERB I-LF
unit NOUN I-LF
; PUNCT O
EAAFly PROPN B-AC
, PUNCT O
fly NOUN B-LF
essential ADJ I-LF
amino NOUN I-LF
acid NOUN I-LF
; PUNCT O
HD PROPN B-AC
, PUNCT O
Holidic PROPN B-LF
Diet PROPN I-LF
; PUNCT O
LpNC8 PROPN B-AC
, PUNCT O
L. NOUN O
plantarumNC8 NOUN O
; PUNCT O
NALs PROPN B-AC
, PUNCT O
nucleic ADJ O
acids NOUN O
and CCONJ O
lipids NOUN O
; PUNCT O
NEAAFLY PROPN O
, PUNCT O
fly NOUN O
nonessential ADJ O
amino NOUN O
acid NOUN O
; PUNCT O
ODMax PROPN B-AC
, PUNCT O
maximal ADJ B-LF
optical ADJ I-LF
density NOUN I-LF
. PUNCT O

BZD PROPN B-AC
, PUNCT O
benzodiazepine NOUN B-LF
or CCONJ I-LF
benzodiazepine NOUN I-LF
- PUNCT I-LF
related VERB I-LF
drug NOUN I-LF
. PUNCT O

Patients NOUN O
with ADP O
DCB PROPN B-AC
displayed VERB O
a DET O
higher ADJ O
proportion NOUN O
of ADP O
tumor NOUN B-LF
- PUNCT I-LF
infiltrating VERB I-LF
T PROPN I-LF
lymphocytes NOUN I-LF
( PUNCT O
TIL PROPN B-AC
) PUNCT O
( PUNCT O
n NOUN O
= SYM O
24 NUM O
, PUNCT O
Mann PROPN O
- PUNCT O
Whitney PROPN O
p NOUN O
= SYM O
0.047 NUM O
) PUNCT O
. PUNCT O

The DET O
highest ADJ O
homology NOUN O
is AUX O
with ADP O
a DET O
16/17 NUM O
- PUNCT O
base NOUN B-LF
pair NOUN I-LF
( PUNCT O
bp NOUN B-AC
) PUNCT O
match NOUN O
to ADP O
OL2 NOUN O
, PUNCT O
and CCONJ O
it PRON O
occurs VERB O
within ADP O
the DET O
open ADJ O
reading NOUN O
frame NOUN O
of ADP O
rlpB NOUN O
, PUNCT O
a DET O
gene NOUN O
coding VERB O
for ADP O
an DET O
inner ADJ O
membrane NOUN O
lipoprotein NOUN O
. PUNCT O

We PRON O
previously ADV O
showed VERB O
that SCONJ O
bone NOUN B-LF
marrow NOUN I-LF
- PUNCT I-LF
derived VERB I-LF
macrophages NOUN I-LF
( PUNCT O
BMMs PROPN B-AC
) PUNCT O
from ADP O
sg NOUN B-AC
/ SYM B-AC
sg NOUN B-AC
mice NOUN O
displayed VERB O
significantly ADV O
reduced VERB O
mRNA NOUN B-AC
expression NOUN O
of ADP O
Ch25h NOUN B-AC
and CCONJ O
deficient ADJ O
phagocytosis NOUN O
[ PUNCT O
23 NUM O
] PUNCT O
. PUNCT O

BI PROPN B-AC
, PUNCT O
Barthel PROPN B-LF
Index NOUN I-LF
; PUNCT O
IS PROPN B-AC
, PUNCT O
ischaemic ADJ B-LF
stroke NOUN I-LF
. PUNCT O

We PRON O
assessed VERB O
risk NOUN O
of ADP O
bias NOUN O
for ADP O
each DET O
key ADJ O
outcome NOUN O
using VERB O
the DET O
Grading PROPN B-LF
of ADP I-LF
Recommendations PROPN I-LF
Assessment PROPN I-LF
, PUNCT I-LF
Development PROPN I-LF
and CCONJ I-LF
Evaluation PROPN I-LF
( PUNCT O
GRADE PROPN B-AC
) PUNCT O
approach NOUN O
[ PUNCT O
28 NUM O
] PUNCT O
and CCONJ O
created VERB O
‘ PUNCT O
Summary PROPN O
of ADP O
findings NOUN O
’ PUNCT O
tables NOUN O
using VERB O
GRADEpro PROPN O
Guideline PROPN O
Development PROPN O
Tool PROPN O
[ PUNCT O
29 NUM O
] PUNCT O
. PUNCT O

Here ADV O
we PRON O
compared VERB O
the DET O
expression NOUN O
profile NOUN O
of ADP O
lncRNAs NOUN B-AC
in ADP O
cold ADJ O
acclimated VERB O
zebrafish NOUN B-LF
embryonic ADJ I-LF
fibroblast NOUN I-LF
cells NOUN I-LF
( PUNCT O
ZF4 PROPN B-AC
) PUNCT O
cultured VERB O
at ADP O
18 NUM O
° NOUN O
C NOUN O
for ADP O
30 NUM O
days NOUN O
with ADP O
that PRON O
of ADP O
cells NOUN O
cultured VERB O
at ADP O
28 NUM O
° NOUN O
C NOUN O
as ADP O
control NOUN O
by ADP O
high ADJ O
- PUNCT O
throughput NOUN O
sequencing NOUN O
. PUNCT O

Multidrug NOUN B-LF
- PUNCT I-LF
resistant ADJ I-LF
tuberculosis NOUN I-LF
( PUNCT O
MDR PROPN B-AC
- PUNCT B-AC
TB PROPN B-AC
) PUNCT O
is AUX O
an DET O
important ADJ O
global ADJ O
health NOUN O
problem NOUN O
, PUNCT O
and CCONJ O
a DET O
control NOUN O
strategy NOUN O
known VERB O
as ADP O
DOTS PROPN O
- PUNCT O
Plus PROPN O
has AUX O
existed VERB O
since SCONJ O
1999 NUM O
. PUNCT O

transcription NOUN B-LF
termination NOUN I-LF
/ SYM I-LF
antitermination NOUN I-LF
protein NOUN I-LF
nusG NOUN I-LF

Minc NOUN B-AC
= PUNCT O
motor NOUN B-LF
incongruence NOUN I-LF
. PUNCT O

Abbreviations NOUN O
: PUNCT O
GLP-1 PROPN B-AC
, PUNCT O
glucagon NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
peptide NOUN I-LF
1 NUM I-LF
; PUNCT O
n NOUN O
/ SYM O
a NOUN O
, PUNCT O
not PART O
applicable ADJ O
; PUNCT O
PYY3 NOUN B-AC
- PUNCT B-AC
36 NUM B-AC
, PUNCT O
peptide NOUN B-LF
YY3 NOUN I-LF
- PUNCT I-LF
36 NUM I-LF
. PUNCT O

The DET O
objective NOUN O
of ADP O
the DET O
present ADJ O
study NOUN O
was AUX O
to PART O
evaluate VERB O
the DET O
efficacy NOUN O
of ADP O
the DET O
Attempted PROPN B-LF
Suicide PROPN I-LF
Short PROPN I-LF
Intervention PROPN I-LF
Program PROPN I-LF
( PUNCT O
ASSIP PROPN B-AC
) PUNCT O
in ADP O
reducing VERB O
suicidal ADJ O
behavior NOUN O
. PUNCT O

In ADP O
addition NOUN O
, PUNCT O
in ADP O
498 NUM O
( PUNCT O
37.4 NUM O
% NOUN O
) PUNCT O
patients NOUN O
who PRON O
had VERB O
available ADJ O
b ADJ B-LF
- ADJ I-LF
type NOUN I-LF
natriuretic ADJ I-LF
peptide NOUN I-LF
( PUNCT O
BNP PROPN B-AC
) PUNCT O
measurements NOUN O
, PUNCT O
the DET O
added VERB O
value NOUN O
of ADP O
CSI PROPN B-AC
on ADP O
the DET O
top NOUN O
of ADP O
the DET O
Brest PROPN O
score NOUN O
and CCONJ O
BNP PROPN B-AC
was AUX O
assessed VERB O
. PUNCT O

We PRON O
compared VERB O
the DET O
activities NOUN O
of ADP O
wild ADJ B-LF
type NOUN I-LF
eNOS PROPN I-LF
( PUNCT O
WT PROPN B-AC
eNOS PROPN B-AC
) PUNCT O
and CCONJ O
S1179D NOUN B-AC
eNOS PROPN B-AC
by ADP O
measuring VERB O
the DET O
L-[C14]arginine NOUN O
to ADP O
L-[C14]citrulline NOUN O
conversion NOUN O
rate NOUN O
. PUNCT O

A DET O
literature NOUN O
review NOUN O
reveals VERB O
two NUM O
studies NOUN O
only ADV O
: PUNCT O
One NUM O
focusing VERB O
on ADP O
prostasomes NOUN O
from ADP O
seminal ADJ O
fluid NOUN O
isolated VERB O
by ADP O
sequential ADJ B-LF
ultracentrifugation NOUN I-LF
( PUNCT O
SUC PROPN B-AC
) PUNCT O
, PUNCT O
size NOUN B-LF
exclusion NOUN I-LF
chromatography NOUN I-LF
( PUNCT O
SEC PROPN B-AC
) PUNCT O
and CCONJ O
sucrose NOUN B-LF
gradient NOUN I-LF
( PUNCT O
SG NOUN B-AC
) PUNCT O
followed VERB O
by ADP O
lipid NOUN O
analysis NOUN O
by ADP O
LC PROPN B-AC
- PUNCT B-AC
MS PROPN B-AC
[ PUNCT O
35 NUM O
] PUNCT O
. PUNCT O

The DET O
flagellation NOUN O
levels NOUN O
of ADP O
the DET O
FliK PROPN O
mutants NOUN O
were AUX O
not PART O
significantly ADV O
different ADJ O
, PUNCT O
with ADP O
an DET O
average NOUN O
of ADP O
3.8 NUM O
± SYM O
1.5 NUM O
flagella NOUN O
per ADP O
cell NOUN O
( PUNCT O
averaged VERB O
across ADP O
all DET O
FliK PROPN O
mutants NOUN O
) PUNCT O
compared VERB O
to ADP O
3.6 NUM O
± SYM O
1.3 NUM O
flagella NOUN O
per ADP O
cell NOUN O
for ADP O
the DET O
wild ADJ B-LF
type NOUN I-LF
( PUNCT O
wt NOUN B-AC
) PUNCT O
, PUNCT O
except SCONJ O
for ADP O
the DET O
shorter ADJ O
FliK PROPN O
variants NOUN O
FliK310 PROPN O
and CCONJ O
FliK377 PROPN O
( PUNCT O
Fig PROPN O
1D NUM O
, PUNCT O
S2 NOUN O
Fig PROPN O
, PUNCT O
S1 NOUN O
Data PROPN O
) PUNCT O
. PUNCT O

As SCONJ O
shown VERB O
in ADP O
Fig NOUN O
1B NUM O
, PUNCT O
the DET O
structure NOUN O
of ADP O
CSL PROPN B-AC
consists VERB O
of ADP O
three NUM O
domains NOUN O
: PUNCT O
NTD PROPN B-AC
( PUNCT O
N NOUN B-LF
- NOUN I-LF
terminal NOUN I-LF
domain NOUN I-LF
) PUNCT O
, PUNCT O
BTD PROPN B-AC
( PUNCT O
β NOUN B-LF
- NOUN I-LF
trefoil NOUN I-LF
domain NOUN I-LF
) PUNCT O
, PUNCT O
and CCONJ O
CTD NOUN B-AC
( PUNCT O
C NOUN B-LF
- NOUN I-LF
terminal NOUN I-LF
domain NOUN I-LF
) PUNCT O
[ PUNCT O
11 NUM O
] PUNCT O
. PUNCT O

For ADP O
continuous ADJ O
measurements NOUN O
of ADP O
Bax PROPN O
insertion NOUN O
in ADP O
OMVs NOUN B-AC
, PUNCT O
we PRON O
adapted VERB O
a DET O
fluorometric ADJ O
method NOUN O
[ X O
26 NUM O
] X O
that PRON O
takes VERB O
advantage NOUN O
of ADP O
the DET O
increased VERB O
fluorescence NOUN O
of ADP O
Bax PROPN O
labeled VERB O
with ADP O
NBD NOUN B-AC
[ X O
N NOUN B-LF
, PUNCT I-LF
N′-dimethyl NOUN I-LF
- PUNCT I-LF
N-(iodoacetyl)-N′-(7 NOUN I-LF
- PUNCT I-LF
nitrobenz-2 NOUN I-LF
- PUNCT I-LF
oxa-1,3 NOUN I-LF
- PUNCT I-LF
diazol-4yl)ethylenediamine NOUN I-LF
] X O
that PRON O
occurs VERB O
upon SCONJ O
membrane NOUN O
insertion NOUN O
. PUNCT O

Another DET O
limitation NOUN O
is AUX O
that SCONJ O
the DET O
Child PROPN B-LF
Feeding PROPN I-LF
Questionnaire PROPN I-LF
for ADP I-LF
adolescents NOUN I-LF
( PUNCT O
CFQ PROPN B-AC
- PUNCT B-AC
A PROPN B-AC
) PUNCT O
was AUX O
only ADV O
translated VERB O
into ADP O
German ADJ O
language NOUN O
for ADP O
this DET O
study NOUN O
. PUNCT O

HW PROPN B-AC
, PUNCT O
health NOUN B-LF
warning NOUN I-LF
; PUNCT O
NFt PROPN B-AC
, PUNCT O
Nutrition PROPN B-LF
Facts PROPN I-LF
table NOUN I-LF
; PUNCT O
NS PROPN B-AC
, PUNCT O
nutri NOUN B-LF
- PUNCT I-LF
score NOUN I-LF
; PUNCT O
NW PROPN B-AC
, PUNCT O
nutrient NOUN B-LF
warning NOUN I-LF
; PUNCT O
RCT PROPN B-AC
, PUNCT O
randomised ADJ B-LF
controlled ADJ I-LF
trial NOUN I-LF
; PUNCT O
TLS PROPN B-AC
, PUNCT O
traffic NOUN B-LF
light NOUN I-LF
labelling NOUN I-LF
system NOUN I-LF
. PUNCT O

Most ADV O
often ADV O
, PUNCT O
studies NOUN O
in ADP O
this DET O
area NOUN O
focus VERB O
on ADP O
the DET O
effects NOUN O
of ADP O
OMT PROPN B-AC
on ADP O
patients NOUN O
suffering VERB O
from ADP O
COPD PROPN B-AC
( PUNCT O
Chronic ADJ B-LF
Obstructive ADJ I-LF
Pulmonary PROPN I-LF
Disease PROPN I-LF
) PUNCT O
[ PUNCT O
1,4–6 NUM O
] PUNCT O
. PUNCT O

The DET O
proteases NOUN O
( PUNCT O
secretases NOUN O
) PUNCT O
that PRON O
cleave VERB O
amyloid NOUN B-LF
- PUNCT I-LF
β NOUN I-LF
( PUNCT O
Aβ NOUN B-AC
) PUNCT O
peptide NOUN O
from ADP O
the DET O
amyloid NOUN B-LF
precursor NOUN I-LF
protein NOUN I-LF
( PUNCT O
APP NOUN B-AC
) PUNCT O
have AUX O
been AUX O
the DET O
focus NOUN O
of ADP O
considerable ADJ O
investigation NOUN O
in ADP O
the DET O
development NOUN O
of ADP O
treatments NOUN O
for ADP O
Alzheimer PROPN O
disease NOUN O
. PUNCT O

Additionally ADV O
, PUNCT O
we PRON O
generated VERB O
Girdin PROPN B-AC
knockout NOUN O
cells NOUN O
by ADP O
clustered VERB B-LF
regularly ADV I-LF
interspaced VERB I-LF
short ADJ I-LF
palindromic ADJ I-LF
repeat NOUN I-LF
/ SYM I-LF
CRISPR NOUN I-LF
- PUNCT I-LF
associated VERB I-LF
9 NUM I-LF
( PUNCT O
CRISPR NOUN B-AC
/ SYM B-AC
Cas9)-mediated NOUN O
genome NOUN O
editing NOUN O
( PUNCT O
S1D PROPN O
– SYM O
S1F PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

1 NUM O
N NOUN O
/ SYM O
A NOUN O
, PUNCT O
not PART O
applicable ADJ O
; PUNCT O
NG PROPN B-AC
, PUNCT O
naso ADJ O
- NOUN O
gastric ADJ O
; PUNCT O
NJ PROPN B-AC
, PUNCT O
naso ADJ O
- NOUN O
jejeunal NOUN O
; PUNCT O
NNS PROPN B-AC
, PUNCT O
no DET O
nutrition NOUN O
support NOUN O
; PUNCT O
PAB PROPN O
, PUNCT O
prophylactic ADJ O
anti NOUN O
- NOUN O
biotics NOUN O
; PUNCT O
SAP PROPN O
, PUNCT O
severe ADJ O
acute ADJ O
pancreatitis NOUN O
; PUNCT O
TPN PROPN B-AC
, PUNCT O
total ADJ B-LF
parenteral ADJ I-LF
nutrition NOUN I-LF
. PUNCT O

Abbreviation NOUN O
: PUNCT O
BMI PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
CI PROPN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF

Acetyl NOUN O
- PUNCT O
CoA PROPN O
, PUNCT O
acetyl NOUN O
coenzyme NOUN O
A NOUN O
; PUNCT O
LOS PROPN B-AC
, PUNCT O
lipooligosaccharide NOUN B-LF
; PUNCT O
OAA PROPN B-AC
, PUNCT O
oxaloacetate NOUN B-LF
; PUNCT O
PEP PROPN B-AC
, PUNCT O
phosphoenolpyruvic NOUN B-LF
acid NOUN I-LF
; PUNCT O
PPP PROPN B-AC
, PUNCT O
pentose NOUN B-LF
phosphate NOUN I-LF
pathway NOUN I-LF
. PUNCT O

RTL PROPN B-AC
was AUX O
measured VERB O
by ADP O
monochrome NOUN B-LF
multiplex NOUN I-LF
quantitative ADJ I-LF
polymerase NOUN I-LF
chain NOUN I-LF
reaction NOUN I-LF
( PUNCT O
MMQPCR PROPN B-AC
) PUNCT O
[ X O
24 NUM O
] X O
using VERB O
a DET O
non ADJ O
- PUNCT O
homologous ADJ O
primer NOUN O
set VERB O
for ADP O
the DET O
telomere NOUN O
repeats NOUN O
and CCONJ O
a DET O
GC NOUN O
- PUNCT O
clamp NOUN O
primer NOUN O
set VERB O
for ADP O
the DET O
single ADJ B-LF
copy NOUN I-LF
gene NOUN I-LF
( PUNCT O
SCG PROPN B-AC
) PUNCT O
albumin NOUN O
. PUNCT O

We PRON O
used VERB O
principal ADJ B-LF
component NOUN I-LF
analysis NOUN I-LF
( PUNCT O
PCA NOUN B-AC
) PUNCT O
to PART O
cluster VERB O
animals NOUN O
based VERB O
on ADP O
protein NOUN O
expression NOUN O
profiles NOUN O
and CCONJ O
to PART O
identify VERB O
key ADJ O
proteins NOUN O
driving VERB O
this DET O
clustering NOUN O
. PUNCT O

Guided VERB O
by ADP O
EUCAST PROPN B-AC
, PUNCT O
isolates NOUN O
showing VERB O
reduced VERB O
susceptibility NOUN O
to ADP O
cefoxitin NOUN O
( PUNCT O
MIC NOUN B-AC
> NUM O
8 NUM O
μg NOUN O
/ X O
ml NOUN O
) PUNCT O
were AUX O
identified VERB O
as ADP O
a DET O
potential ADJ O
AmpC PROPN B-LF
beta NOUN I-LF
- PUNCT I-LF
lactamase NOUN I-LF
producer NOUN O
. PUNCT O

Among ADP O
the DET O
factors NOUN O
implicated VERB O
in ADP O
the DET O
development NOUN O
of ADP O
a DET O
reactive ADJ O
stroma NOUN O
, PUNCT O
in ADP O
particular ADJ O
the DET O
recruitment NOUN O
and CCONJ O
phenotypic ADJ O
character NOUN O
of ADP O
CAFs PROPN B-AC
, PUNCT O
are AUX O
members NOUN O
of ADP O
the DET O
transforming VERB O
growth NOUN O
factor NOUN O
- PUNCT O
β NOUN O
and CCONJ O
the DET O
platelet NOUN B-LF
- PUNCT I-LF
derived VERB I-LF
growth NOUN I-LF
factor NOUN I-LF
( PUNCT O
PDGF PROPN B-AC
) PUNCT O
families NOUN O
[ X O
4,6,12 NUM O
] PUNCT O
. PUNCT O

The DET O
objectives NOUN O
of ADP O
the DET O
current ADJ O
crossover NOUN O
study NOUN O
of ADP O
subjects NOUN O
with ADP O
MetS PROPN B-AC
were AUX O
to ADP O
determine VERB O
how SCONJ O
an DET O
AX- PROPN B-AC
and CCONJ O
RS PROPN B-AC
- PUNCT O
enriched VERB O
diet NOUN O
, PUNCT O
hereafter ADV O
referred VERB O
to ADP O
as ADP O
a DET O
healthy ADJ B-LF
- PUNCT I-LF
carbohydrate NOUN I-LF
diet NOUN I-LF
( PUNCT O
HCD PROPN B-AC
) PUNCT O
, PUNCT O
alters VERB O
the DET O
microbiome NOUN O
and CCONJ O
SCFA PROPN O
concentrations NOUN O
in ADP O
faeces NOUN O
compared VERB O
with ADP O
a DET O
low ADJ O
- PUNCT O
fibre NOUN O
Western ADJ B-LF
- PUNCT I-LF
style NOUN I-LF
diet NOUN I-LF
( PUNCT O
WSD PROPN B-AC
) PUNCT O
. PUNCT O
We PRON O
hypothesised VERB O
that SCONJ O
AX PROPN B-AC
and CCONJ O
RS PROPN B-AC
would AUX O
beneficially ADV O
change VERB O
the DET O
intestinal ADJ O
microbiota NOUN O
and CCONJ O
enhance VERB O
colonic ADJ O
SCFA PROPN O
production NOUN O
in ADP O
general ADJ O
and CCONJ O
butyrate VERB O
in ADP O
particular ADJ O
compared VERB O
with ADP O
the DET O
WSD PROPN B-AC
. PUNCT O

Acid NOUN B-LF
soluble ADJ I-LF
matrix NOUN I-LF
( PUNCT O
ASM PROPN B-AC
) PUNCT O
and CCONJ O
acid NOUN B-LF
insoluble ADJ I-LF
matrix NOUN I-LF
( PUNCT O
AIM PROPN B-AC
) PUNCT O
fractions NOUN O
of ADP O
the DET O
skeleton NOUN O
stained VERB O
by ADP O
silver NOUN O
staining NOUN O
. PUNCT O

This DET O
problem NOUN O
is AUX O
particularly ADV O
acute ADJ O
in ADP O
sub ADJ B-LF
- ADJ I-LF
Saharan PROPN I-LF
Africa PROPN I-LF
( PUNCT O
SSA PROPN B-AC
) PUNCT O
, PUNCT O
where SCONJ O
most ADJ O
of ADP O
the DET O
world NOUN O
’s PART O
HIV PROPN O
– PUNCT O
positive ADJ O
women NOUN O
live VERB O
[ X O
7 NUM O
] PUNCT O
and CCONJ O
where SCONJ O
GBV PROPN B-AC
prevalence NOUN O
is AUX O
highest ADJ O
[ X O
8 NUM O
] PUNCT O
. PUNCT O

The DET O
program NOUN O
, PUNCT O
which PRON O
was AUX O
financed VERB O
by ADP O
anticipated ADJ O
carbon NOUN O
credits NOUN O
[ PUNCT O
25 NUM O
] PUNCT O
, PUNCT O
was AUX O
implemented VERB O
by ADP O
the DET O
UK PROPN O
- PUNCT O
based VERB O
social ADJ O
enterprise NOUN O
DelAgua PROPN O
Health PROPN O
in ADP O
collaboration NOUN O
with ADP O
the DET O
Rwanda PROPN O
Ministry PROPN B-LF
of ADP I-LF
Health PROPN I-LF
( PUNCT O
MOH PROPN B-AC
) PUNCT O
and CCONJ O
targeted VERB O
households NOUN O
in ADP O
Ubudehe PROPN O
categories NOUN O
1 NUM O
and CCONJ O
2 NUM O
— PUNCT O
roughly ADV O
the DET O
government NOUN O
- PUNCT O
designated VERB O
poorest ADJ O
25 NUM O
% NOUN O
of ADP O
households NOUN O
in ADP O
the DET O
province NOUN O
[ PUNCT O
26 NUM O
] PUNCT O
. PUNCT O

Gestational ADJ B-LF
diabetes NOUN I-LF
mellitus NOUN I-LF
( PUNCT O
GDM PROPN B-AC
) PUNCT O
is AUX O
defined VERB O
as ADP O
glucose NOUN O
intolerance NOUN O
that PRON O
begins VERB O
or CCONJ O
is AUX O
first ADV O
recognized VERB O
during ADP O
pregnancy NOUN O
. PUNCT O

CLR PROPN B-AC
, PUNCT O
composite ADJ B-LF
likelihood NOUN I-LF
ratio NOUN I-LF
; PUNCT O
CRE PROPN B-AC
, PUNCT O
cis ADJ B-LF
- PUNCT I-LF
regulatory ADJ I-LF
element NOUN I-LF
; PUNCT O
SNP PROPN O
, PUNCT O
single ADJ O
- PUNCT O
nucleotide NOUN O
polymorphism NOUN O

HLA PROPN O
- NOUN O
DR1 PROPN B-AC
( PUNCT O
DRB1 NOUN B-LF
* NOUN I-LF
0101 NOUN I-LF
) PUNCT O
binding VERB O
epitopes NOUN O
were AUX O
predicted VERB O
using VERB O
the DET O
genomic ADJ O
sequences NOUN O
of ADP O
vaccinia NOUN O
virus NOUN O
strain NOUN O
MVA PROPN B-AC
[ X O
39 NUM O
] PUNCT O
. PUNCT O

As ADP O
an DET O
endogenously ADV O
occurring VERB O
population NOUN O
of ADP O
NPs NOUN B-AC
, PUNCT O
human ADJ B-LF
central ADJ I-LF
nervous ADJ I-LF
system NOUN I-LF
stem NOUN I-LF
cells NOUN I-LF
grown VERB I-LF
as ADP I-LF
neurospheres NOUN I-LF
( PUNCT O
hCNS NOUN B-AC
- PUNCT B-AC
SCns NOUN B-AC
) PUNCT O
were AUX O
utilized VERB O
as ADP O
a DET O
natural ADJ O
benchmark NOUN O
for ADP O
derived VERB O
NPs NOUN B-AC
. PUNCT O
We PRON O
developed VERB O
an DET O
approach NOUN O
called VERB O
REAP PROPN B-AC
( PUNCT O
Regression NOUN B-LF
- PUNCT I-LF
based VERB I-LF
Exon PROPN I-LF
Array PROPN I-LF
Protocol PROPN I-LF
) PUNCT O
, PUNCT O
which PRON O
is AUX O
based VERB O
on ADP O
robust ADJ O
regression NOUN O
that PRON O
analyzed VERB O
signal NOUN O
estimates NOUN O
from ADP O
Affymetrix PROPN O
exon NOUN O
array NOUN O
data NOUN O
to PART O
identify VERB O
AS NOUN B-AC
exons NOUN O
. PUNCT O

Head NOUN B-LF
and CCONJ I-LF
neck NOUN I-LF
squamous ADJ I-LF
cell NOUN I-LF
carcinoma NOUN I-LF
( PUNCT O
HNSCC PROPN B-AC
) PUNCT O
is AUX O
a DET O
global ADJ O
disease NOUN O
and CCONJ O
mortality NOUN O
burden NOUN O
, PUNCT O
necessitating VERB O
the DET O
elucidation NOUN O
of ADP O
its PRON O
molecular ADJ O
progression NOUN O
for ADP O
effective ADJ O
disease NOUN O
management NOUN O
. PUNCT O

Activation NOUN O
of ADP O
the DET O
AMP NOUN B-LF
- PUNCT I-LF
activated VERB I-LF
protein NOUN I-LF
kinase NOUN I-LF
( PUNCT O
AMPK PROPN B-AC
) PUNCT O
is AUX O
an DET O
attractive ADJ O
approach NOUN O
for ADP O
the DET O
treatment NOUN O
of ADP O
type NOUN O
2 NUM O
diabetes NOUN O
. PUNCT O

How SCONJ O
naturalistic ADJ O
vibrations NOUN O
, PUNCT O
and CCONJ O
by ADP O
extension NOUN O
texture NOUN O
, PUNCT O
are AUX O
encoded VERB O
in ADP O
the DET O
responses NOUN O
of ADP O
neurons NOUN O
in ADP O
primary ADJ B-LF
somatosensory NOUN I-LF
cortex NOUN I-LF
( PUNCT O
S1 NOUN B-AC
) PUNCT O
is AUX O
unknown ADJ O
. PUNCT O

COPD PROPN B-AC
: PUNCT O
Chronic ADJ B-LF
Obstructive ADJ I-LF
Pulmonary ADJ I-LF
Disease NOUN I-LF
. PUNCT O

OMT PROPN B-AC
— PUNCT O
Osteopathic ADJ O
Manual PROPN O
Therapy NOUN O
; PUNCT O
STT PROPN B-AC
— PUNCT O
soft ADJ B-LF
tissue NOUN I-LF
therapy NOUN I-LF
; PUNCT O
FVC PROPN B-AC
— PUNCT O
Forced VERB B-LF
Vital ADJ I-LF
Capacity PROPN I-LF
; PUNCT O
FEV1 PROPN B-AC
— PUNCT O
Forced VERB B-LF
Expiratory NOUN I-LF
Volume NOUN I-LF
in ADP I-LF
1 NUM I-LF
second NOUN I-LF
; PUNCT O
PEF PROPN B-AC
— PUNCT O
Peak NOUN B-LF
Expiratory NOUN I-LF
Flow NOUN I-LF

Abbreviations NOUN O
: PUNCT O
sec PROPN O
. PUNCT O
, PUNCT O
secondary ADJ O
; PUNCT O
TBI PROPN B-AC
, PUNCT O
traumatic ADJ B-LF
brain NOUN I-LF
injury NOUN I-LF
. PUNCT O

Cells NOUN O
were AUX O
sorted VERB O
by ADP O
FACS PROPN O
Aria PROPN O
III NUM O
Flow PROPN O
Sorter PROPN O
in ADP O
CMBI PROPN O
high ADJ O
throughput NOUN O
single ADJ O
- PUNCT O
cell NOUN O
analysis NOUN O
facility NOUN O
( PUNCT O
HTSCAF PROPN O
) PUNCT O
for ADP O
yellow ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
( PUNCT O
YFP PROPN B-AC
) PUNCT O
expression NOUN O
. PUNCT O

Infections NOUN O
with ADP O
lymphocytic ADJ B-LF
choriomeningitis NOUN I-LF
virus NOUN I-LF
( PUNCT O
LCMV PROPN B-AC
) PUNCT O
provide VERB O
potent ADJ O
stimuli NOUN O
for ADP O
Th1 NOUN O
- PUNCT O
cell NOUN O
polarization NOUN O
[ PUNCT O
12 NUM O
] PUNCT O
. PUNCT O

CES PROPN B-AC
, PUNCT O
chromatin NOUN B-LF
entry NOUN I-LF
site NOUN I-LF
; PUNCT O
MRE PROPN B-AC
, PUNCT O
MSL PROPN B-LF
recognition NOUN I-LF
element NOUN I-LF
; PUNCT O
MSL PROPN B-AC
, PUNCT O
male NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
lethal ADJ I-LF
; PUNCT O
pion NOUN B-AC
- PUNCT B-AC
X NOUN B-AC
site NOUN B-AC
, PUNCT O
pioneering VERB B-LF
site NOUN I-LF
on ADP I-LF
the DET I-LF
X. PUNCT I-LF

The DET O
increased VERB O
global ADJ O
incidence NOUN O
and CCONJ O
prevalence NOUN O
of ADP O
diabetes NOUN O
, PUNCT O
hypertension NOUN O
, PUNCT O
obesity NOUN O
and CCONJ O
other ADJ O
risk NOUN O
factors NOUN O
for ADP O
kidney NOUN O
disease NOUN O
is AUX O
associated VERB O
with ADP O
an DET O
increased VERB O
incidence NOUN O
of ADP O
end NOUN B-LF
- ADJ I-LF
stage NOUN I-LF
renal ADJ I-LF
disease NOUN I-LF
( PUNCT O
ESRD).[1 NOUN B-AC
] PUNCT O
The DET O
golden ADJ O
standard ADJ O
treatment NOUN O
for ADP O
patients NOUN O
with ADP O
ESRD PROPN B-AC
is AUX O
kidney NOUN O
transplantation NOUN O
, PUNCT O
but CCONJ O
unfortunately ADV O
, PUNCT O
this DET O
field NOUN O
is AUX O
still ADV O
suffering VERB O
from ADP O
the DET O
lack NOUN O
of ADP O
donor NOUN O
organs.[2 NOUN O
] PUNCT O
Luckily ADV O
, PUNCT O
during ADP O
the DET O
last ADJ O
decades NOUN O
, PUNCT O
live ADJ O
kidney NOUN O
donation NOUN O
has AUX O
proven VERB O
to ADP O
successfully ADV O
expand VERB O
the DET O
donor NOUN O
pool NOUN O
; PUNCT O
unfortunately ADV O
, PUNCT O
it PRON O
still ADV O
can AUX O
not PART O
meet VERB O
the DET O
demand NOUN O
for ADP O
donor NOUN O
kidneys.[2 PUNCT O
] PUNCT O
This PRON O
, PUNCT O
together ADV O
with ADP O
the DET O
excellent ADJ O
results NOUN O
of ADP O
live ADJ O
donor NOUN O
kidney NOUN O
transplantation NOUN O
, PUNCT O
leads VERB O
to ADP O
an DET O
increase NOUN O
in ADP O
the DET O
acceptance NOUN O
of ADP O
live ADJ O
donors NOUN O
with ADP O
so ADV O
called VERB O
‘ PUNCT O
extended ADJ O
donor NOUN O
criteria NOUN O
’ PUNCT O
, PUNCT O
i.e. X O
, PUNCT O
older ADJ O
donors NOUN O
, PUNCT O
overweight ADJ O
/ SYM O
obese ADJ O
donors NOUN O
, PUNCT O
donor NOUN O
kidneys NOUN O
with ADP O
vascular ADJ O
multiplicity NOUN O
, PUNCT O
donors NOUN O
with ADP O
comorbidities NOUN O
, PUNCT O
women NOUN O
of ADP O
childbearing NOUN O
age NOUN O
, PUNCT O
and CCONJ O
even ADV O
minors NOUN O
as ADP O
potential ADJ O
donors.[3 NOUN O
] PUNCT O
In ADP O
general ADJ O
, PUNCT O
live ADJ O
kidney NOUN O
donors NOUN O
are AUX O
in ADP O
good ADJ O
health NOUN O
, PUNCT O
and CCONJ O
therefore ADV O
it PRON O
is AUX O
critical ADJ O
that SCONJ O
these DET O
potential ADJ O
donors NOUN O
do AUX O
not PART O
become VERB O
kidney NOUN O
patients NOUN O
themselves PRON O
. PUNCT O

In ADP O
addition NOUN O
, PUNCT O
down ADJ O
- NOUN O
regulation NOUN O
of ADP O
mitochondrial ADJ O
uncoupling NOUN B-LF
protein NOUN I-LF
2 NUM I-LF
( PUNCT O
Ucp2 NOUN B-AC
) PUNCT O
was AUX O
observed VERB O
in ADP O
brown ADJ O
adipose NOUN O
in ADP O
Oct1-/- NOUN O
mice NOUN O
( PUNCT O
S5 PROPN O
G PROPN O
Fig PROPN O
) PUNCT O
, PUNCT O
which PRON O
may AUX O
associate VERB O
with ADP O
the DET O
reduced VERB O
energy NOUN O
expenditure NOUN O
. PUNCT O

The DET O
aim NOUN O
of ADP O
this DET O
study NOUN O
was AUX O
to PART O
validate VERB O
and CCONJ O
correlate VERB O
the DET O
performance NOUN O
of ADP O
cobas NOUN O
HCV PROPN B-AC
with ADP O
the DET O
established VERB O
CAP PROPN B-AC
/ SYM B-AC
CTM PROPN B-AC
in ADP O
a DET O
large ADJ O
patient NOUN O
population NOUN O
with ADP O
HCV PROPN B-AC
genotypes NOUN B-LF
( PUNCT O
GT PROPN B-AC
) PUNCT O
1 NUM O
and CCONJ O
3 NUM O
treated VERB O
with ADP O
DAAs PROPN B-AC
. PUNCT O

The DET O
pyloric ADJ O
rhythm NOUN O
is AUX O
triphasic ADJ O
and CCONJ O
consists VERB O
of ADP O
the DET O
alternating VERB O
activities NOUN O
of ADP O
the DET O
PD PROPN B-AC
neurons NOUN O
and CCONJ O
the DET O
lateral ADJ B-LF
pyloric ADJ I-LF
( PUNCT O
LP NOUN B-AC
) PUNCT O
and CCONJ O
pyloric ADJ B-LF
constrictor NOUN I-LF
( PUNCT O
PY PROPN B-AC
) PUNCT O
neurons NOUN O
. PUNCT O

Approximately ADV O
half NOUN O
of ADP O
all DET O
cases NOUN O
of ADP O
CKD PROPN B-AC
in ADP O
children NOUN O
in ADP O
high ADJ O
income NOUN O
countries NOUN O
are AUX O
due ADJ O
to ADP O
congenital ADJ B-LF
anomalies NOUN I-LF
of ADP I-LF
the DET I-LF
kidney NOUN I-LF
and CCONJ I-LF
urinary ADJ I-LF
tract NOUN I-LF
( PUNCT O
CAKUT PROPN B-AC
) PUNCT O
[ PUNCT O
4,5 NUM O
] PUNCT O
. PUNCT O

The DET O
main ADJ O
purpose NOUN O
for ADP O
the DET O
second ADJ O
phase NOUN O
is AUX O
the DET O
generation NOUN O
of ADP O
the DET O
approximate ADJ B-LF
Pareto ADJ I-LF
- NOUN I-LF
optimal ADJ I-LF
solutions NOUN I-LF
XE NOUN B-AC
. PUNCT O
The DET O
pseudo NOUN O
- NOUN O
code NOUN O
of ADP O
the DET O
PLS NOUN B-AC
is AUX O
shown VERB O
in ADP O
algorithm NOUN O
2 NUM O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
CI NOUN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
IQR PROPN O
, PUNCT O
interquartile ADJ O
range NOUN O
; PUNCT O
SD NOUN O
, PUNCT O
standard ADJ O
deviation NOUN O
; PUNCT O
SE NOUN B-AC
, PUNCT O
sleep NOUN B-LF
efficiency NOUN I-LF
; PUNCT O
SOL NOUN B-AC
, PUNCT O
sleep NOUN B-LF
onset NOUN I-LF
latency NOUN I-LF
; PUNCT O
TIB NOUN B-AC
, PUNCT O
time NOUN B-LF
in ADP I-LF
bed NOUN I-LF
; PUNCT O
TST NOUN B-AC
, PUNCT O
total ADJ B-LF
sleep NOUN I-LF
time NOUN I-LF
; PUNCT O
WASO NOUN B-AC
, PUNCT O
wake VERB B-LF
after ADP I-LF
sleep NOUN I-LF
onset NOUN I-LF
. PUNCT O

The DET O
data NOUN O
underlying VERB O
( PUNCT O
G NOUN O
, PUNCT O
H NOUN O
) PUNCT O
can AUX O
be AUX O
found VERB O
in ADP O
S7 PROPN O
Source PROPN O
Data PROPN O
. PUNCT O
aPS PROPN B-AC
, PUNCT O
anterior ADJ B-LF
primitive ADJ I-LF
streak NOUN I-LF
; PUNCT O
DE PROPN O
, PUNCT O
definitive ADJ O
endoderm NOUN O
; PUNCT O
EB NOUN B-AC
, PUNCT O
early ADJ B-LF
bud NOUN I-LF
; PUNCT O
LPM PROPN O
/ SYM O
Ex PROPN O
- PUNCT O
meso NOUN O
, PUNCT O
lateral ADJ O
plate NOUN O
mesoderm NOUN O
and CCONJ O
extraembryonic ADJ O
mesoderm NOUN O
, PUNCT O
mesenchyme NOUN O
; PUNCT O
LS PROPN O
, PUNCT O
late ADJ O
streak NOUN O
; PUNCT O
MS PROPN O
, PUNCT O
mid NOUN O
- PUNCT O
streak NOUN O
; PUNCT O
Nascent PROPN O
meso NOUN O
, PUNCT O
nascent ADJ O
mesoderm NOUN O
; PUNCT O
OB PROPN B-AC
, PUNCT O
no DET B-LF
bud NOUN I-LF
; PUNCT O
PGC PROPN O
, PUNCT O
primordial ADJ O
germs NOUN O
cells NOUN O
; PUNCT O
PS PROPN O
, PUNCT O
primitive ADJ O
streak NOUN O
; PUNCT O
scRNA NOUN O
- PUNCT O
seq NOUN O
, PUNCT O
single ADJ O
- PUNCT O
cell NOUN O
RNA NOUN O
sequencing NOUN O
; PUNCT O
UMAP PROPN B-AC
, PUNCT O
Uniform PROPN B-LF
Manifold PROPN I-LF
Approximation PROPN I-LF
Projection PROPN I-LF
. PUNCT O

The DET O
increased VERB O
risk NOUN O
of ADP O
CVD NOUN B-AC
in ADP O
cancer NOUN O
survivors NOUN O
is AUX O
in ADP O
part NOUN O
associated VERB O
with ADP O
cancer NOUN B-LF
therapy NOUN I-LF
– PUNCT I-LF
related VERB I-LF
cardiac ADJ I-LF
dysfunction NOUN I-LF
( PUNCT O
CTRCD NOUN B-AC
) PUNCT O
[ PUNCT O
4 NUM O
] PUNCT O
, PUNCT O
including VERB O
radiotherapy NOUN O
[ PUNCT O
5 NUM O
] PUNCT O
, PUNCT O
cytotoxic ADJ O
chemotherapy NOUN O
[ PUNCT O
6 NUM O
] PUNCT O
, PUNCT O
targeted VERB O
therapies NOUN O
[ PUNCT O
7–9 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
immunotherapy NOUN O
[ PUNCT O
10–12 NUM O
] PUNCT O
. PUNCT O

Co NOUN O
- PUNCT O
administration NOUN O
of ADP O
efavirenz PROPN O
with ADP O
nucleoside NOUN B-LF
reverse ADJ I-LF
transcriptase NOUN I-LF
inhibitors NOUN I-LF
( PUNCT O
NRTI PROPN B-AC
) PUNCT O
, PUNCT O
namely ADV O
tenofovir NOUN O
disoproxil NOUN O
fumarate NOUN O
and CCONJ O
lamivudine NOUN O
, PUNCT O
or CCONJ O
alternatively ADV O
, PUNCT O
emtricitabine NOUN O
, PUNCT O
is VERB O
currently ADV O
the DET O
preferred ADJ O
first ADJ O
- PUNCT O
line NOUN O
regimen NOUN O
of ADP O
combination NOUN B-LF
antiretroviral ADJ I-LF
therapy NOUN I-LF
( PUNCT O
cART PROPN B-AC
) PUNCT O
. PUNCT O
Although SCONJ O
efavirenz PROPN O
has AUX O
been AUX O
used VERB O
in ADP O
clinical ADJ O
practice NOUN O
for ADP O
almost ADV O
two NUM O
decades NOUN O
, PUNCT O
there PRON O
is VERB O
still ADV O
a DET O
great ADJ O
need NOUN O
for ADP O
deeper ADJ O
knowledge NOUN O
regarding VERB O
the DET O
safety NOUN O
of ADP O
efavirenz PROPN O
- PUNCT O
containing VERB O
treatment NOUN O
regimens NOUN O
[ PUNCT O
2 NUM O
] PUNCT O
. PUNCT O

A X O
, PUNCT O
B NOUN O
; PUNCT O
To PART O
assess VERB O
differentiation NOUN O
of ADP O
OPCs NOUN B-AC
derived VERB O
from ADP O
neonatal ADJ O
rat NOUN O
pups NOUN O
into ADP O
oligodendrocytes NOUN O
, PUNCT O
cells NOUN O
were AUX O
immunolabelled VERB O
with ADP O
antibodies NOUN O
against ADP O
O4 PROPN O
( PUNCT O
red ADJ O
) PUNCT O
and CCONJ O
myelin NOUN B-LF
basic ADJ I-LF
protein NOUN I-LF
( PUNCT O
MBP NOUN B-AC
, PUNCT O
green ADJ O
) PUNCT O
. PUNCT O

HR NOUN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT O
CIs NOUN B-AC
, PUNCT O
confidential ADJ O
intervals NOUN O
; PUNCT O
ER NOUN B-AC
, PUNCT O
estrogen NOUN B-LF
receptor NOUN I-LF
; PUNCT O
PR NOUN B-AC
, PUNCT O
progesterone NOUN B-LF
receptor NOUN I-LF
; PUNCT O
HER-2 NOUN O
, PUNCT O
human ADJ O
epidermal ADJ O
growth NOUN O
factor NOUN O
receptor-2 NOUN O
; PUNCT O
HG NOUN B-AC
, PUNCT O
histologic ADJ B-LF
grade NOUN I-LF
; PUNCT O
LVI PROPN B-AC
, PUNCT O
lymph NOUN O
- PUNCT O
vascular NOUN O
invasion NOUN O
. PUNCT O

6 X O
. PUNCT O
Discussion NOUN O
: PUNCT O
1 X O
) PUNCT O
Line NOUN O
217 NUM O
- SYM O
220 NUM O
: PUNCT O
typo NOUN O
and CCONJ O
consider VERB O
use NOUN O
of ADP O
standard ADJ O
reference NOUN O
for ADP O
“ PUNCT O
mean ADJ O
difference NOUN O
” PUNCT O
( PUNCT O
bias NOUN O
) PUNCT O
as ADP O
the DET O
quantified VERB O
degree NOUN O
of ADP O
agreement NOUN O
and CCONJ O
“ PUNCT O
limits NOUN B-LF
of ADP I-LF
agreement NOUN I-LF
” PUNCT O
( PUNCT O
precision NOUN O
) PUNCT O
as ADP O
SD NOUN B-AC
and CCONJ O
the DET O
95 NUM O
% NOUN O
LOAs NOUN B-AC
. PUNCT O
2 X O
) PUNCT O
Line NOUN O
240 NUM O
– PUNCT O
this PRON O
statement NOUN O
re ADP O
: PUNCT O
“ PUNCT O
… PUNCT O
although SCONJ O
this PRON O
was AUX O
not PART O
statistically ADV O
significant ADJ O
” PUNCT O
was AUX O
not PART O
clear ADJ O
to ADP O
me PRON O
. PUNCT O
3 X O
) PUNCT O
Line NOUN O
266 NUM O
- SYM O
270 NUM O
: PUNCT O
recommend VERB O
using VERB O
hypothermic ADJ O
and CCONJ O
febrile ADJ O
range NOUN O
temperatures NOUN O
. PUNCT O

5HTTLPR PROPN B-AC
, PUNCT O
5HTT NOUN B-LF
- PUNCT I-LF
linked VERB I-LF
polymorphic ADJ I-LF
region NOUN I-LF
. PUNCT O

BMI PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
CI PROPN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
GDM NOUN B-AC
, PUNCT O
gestational ADJ B-LF
diabetes NOUN I-LF
mellitus NOUN I-LF
; PUNCT O
HbA1c NOUN B-AC
, PUNCT O
glycated VERB B-LF
hemoglobin NOUN I-LF
. PUNCT O

The DET O
acute ADJ O
- NOUN O
phase NOUN O
increase NOUN O
in ADP O
serum ADJ O
C NOUN B-LF
- NOUN I-LF
reactive ADJ I-LF
protein NOUN I-LF
( PUNCT O
CRP NOUN B-AC
) PUNCT O
is AUX O
used VERB O
to PART O
diagnose VERB O
and CCONJ O
monitor VERB O
infectious ADJ O
and CCONJ O
inflammatory ADJ O
diseases NOUN O
. PUNCT O

Previous ADJ O
work NOUN O
demonstrated VERB O
minimal ADJ O
rates NOUN O
of ADP O
inappropriate ADJ O
PCIs NOUN B-AC
in ADP O
patients NOUN O
being AUX O
treated VERB O
for ADP O
an DET O
acute ADJ B-LF
coronary ADJ I-LF
syndrome NOUN I-LF
( PUNCT O
ACS PROPN B-AC
) PUNCT O
, PUNCT O
but CCONJ O
almost ADV O
1 NUM O
in ADP O
8 NUM O
procedures NOUN O
in ADP O
the DET O
setting NOUN O
of ADP O
stable ADJ O
coronary ADJ O
artery NOUN O
disease NOUN O
( PUNCT O
CAD PROPN O
) PUNCT O
were AUX O
inappropriate ADJ O
and CCONJ O
nearly ADV O
1 NUM O
in ADP O
6 NUM O
PCIs NOUN B-AC
were AUX O
unmappable ADJ O
due ADP O
to ADP O
missing VERB O
data NOUN O
. PUNCT O
[ X O
4 NUM O
] X O

Phloem NOUN O
differentiation NOUN O
is AUX O
regulated VERB O
by ADP O
transcription NOUN O
factors NOUN O
, PUNCT O
including VERB O
ALTERED VERB B-LF
PHLOEM PROPN I-LF
DEVELOPMENT NOUN I-LF
( PUNCT O
APL PROPN B-AC
) PUNCT O
and CCONJ O
OCTOPUS NOUN B-LF
( PUNCT O
OPS NOUN B-AC
) PUNCT O
[ PUNCT O
15,16 NUM O
] PUNCT O
. PUNCT O

During ADP O
the DET O
consultation NOUN O
, PUNCT O
clinical ADJ O
signs NOUN O
of ADP O
a DET O
relevant ADJ O
focused VERB O
examination NOUN O
were AUX O
also ADV O
recorded VERB O
( PUNCT O
vital ADJ O
and CCONJ O
danger NOUN O
signs NOUN O
, PUNCT O
temperature NOUN O
, PUNCT O
respiratory ADJ O
rate NOUN O
, PUNCT O
malnutrition NOUN O
assessment NOUN O
, PUNCT O
etc X O
. PUNCT O
) PUNCT O
along ADP O
with ADP O
laboratory NOUN O
tests NOUN O
recommended VERB O
by ADP O
the DET O
app NOUN O
( PUNCT O
mRDT NOUN B-AC
, PUNCT O
C NOUN B-LF
- PUNCT I-LF
reactive ADJ I-LF
protein NOUN I-LF
[ PUNCT O
CRP PROPN B-AC
] PUNCT O
, PUNCT O
hemoglobin NOUN O
, PUNCT O
urinary ADJ O
dipstick NOUN O
, PUNCT O
etc X O
. PUNCT O
) PUNCT O
. PUNCT O

HFE PROPN O
wild ADJ B-LF
type NOUN I-LF
( PUNCT O
WT PROPN B-AC
) PUNCT O
, PUNCT O
( PUNCT O
ii X O
) PUNCT O
females NOUN O
vs. ADP O
males NOUN O
. PUNCT O

The DET O
Kidney PROPN B-LF
Failure PROPN I-LF
Risk PROPN I-LF
Equation PROPN I-LF
( PUNCT O
KFRE PROPN B-AC
) PUNCT O
uses VERB O
the DET O
4 NUM O
variables NOUN O
of ADP O
age NOUN O
, PUNCT O
sex NOUN O
, PUNCT O
urine NOUN O
albumin NOUN B-LF
- PUNCT I-LF
to PART I-LF
- PUNCT I-LF
creatinine NOUN I-LF
ratio NOUN I-LF
( PUNCT O
ACR PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
estimated VERB B-LF
glomerular ADJ I-LF
filtration NOUN I-LF
rate NOUN I-LF
( PUNCT O
eGFR PROPN B-AC
) PUNCT O
in ADP O
individuals NOUN O
with ADP O
chronic ADJ B-LF
kidney NOUN I-LF
disease NOUN I-LF
( PUNCT O
CKD PROPN B-AC
) PUNCT O
to PART O
predict VERB O
the DET O
risk NOUN O
of ADP O
end NOUN B-LF
stage NOUN I-LF
renal ADJ I-LF
disease NOUN I-LF
( PUNCT O
ESRD PROPN B-AC
) PUNCT O
, PUNCT O
i.e. X O
, PUNCT O
the DET O
need NOUN O
for ADP O
dialysis NOUN O
or CCONJ O
a DET O
kidney NOUN O
transplant NOUN O
, PUNCT O
within ADP O
2 NUM O
and CCONJ O
5 NUM O
years NOUN O
. PUNCT O

The DET O
gene NOUN O
expression NOUN O
level NOUN O
changes NOUN O
under ADP O
Zinc NOUN B-LF
deficiency NOUN I-LF
( PUNCT O
ZnD PROPN B-AC
) PUNCT O
, PUNCT O
iron NOUN B-LF
deficiency NOUN I-LF
( PUNCT O
FeD NOUN B-AC
) PUNCT O
, PUNCT O
excess ADJ B-LF
Zn NOUN I-LF
( PUNCT O
ZnE NOUN B-AC
) PUNCT O
and CCONJ O
cadmium NOUN B-LF
exposure NOUN I-LF
( PUNCT O
CdE NOUN B-AC
) PUNCT O
compared VERB O
to ADP O
the DET O
normal ADJ O
condition NOUN O
were AUX O
analyzed VERB O
. PUNCT O
( PUNCT O
a X O
) PUNCT O
The DET O
BrGLYI PROPN O
gene NOUN O
expression NOUN O
level NOUN O
, PUNCT O
( PUNCT O
b X O
) PUNCT O
The DET O
BrGLYII PROPN O
gene NOUN O
expression NOUN O
level NOUN O
. PUNCT O

As ADP O
an DET O
orthogonal ADJ O
unbiased ADJ O
high ADJ O
- PUNCT O
throughput NOUN O
approach NOUN O
, PUNCT O
competitive ADJ O
Fluorescence PROPN B-LF
Polarization PROPN I-LF
( PUNCT O
FP PROPN B-AC
) PUNCT O
method NOUN O
has AUX O
also ADV O
been AUX O
used VERB O
to PART O
monitor VERB O
the DET O
interactions NOUN O
of ADP O
the DET O
same ADJ O
PDZ PROPN B-AC
domains NOUN O
with ADP O
PTEN_11 NOUN O
( PUNCT O
Fig PROPN O
3B NUM O
) PUNCT O
. PUNCT O
For ADP O
the DET O
tested VERB O
PDZ PROPN B-AC
/ SYM O
PBM NOUN B-AC
pairs NOUN O
, PUNCT O
the DET O
apparent ADJ O
affinities NOUN O
were AUX O
obtained VERB O
by ADP O
fitting VERB O
the DET O
polarization NOUN O
data NOUN O
considering VERB O
a DET O
competitive ADJ O
binding VERB O
model NOUN O
[ PUNCT O
42 NUM O
] PUNCT O
. PUNCT O

Yunnan PROPN O
province NOUN O
itself PRON O
has VERB O
a DET O
large ADJ O
population NOUN O
of ADP O
people NOUN B-LF
who PRON I-LF
inject VERB I-LF
drugs NOUN I-LF
( PUNCT O
PWID PROPN B-AC
) PUNCT O
[ PUNCT O
15 NUM O
, PUNCT O
16 NUM O
] PUNCT O
. PUNCT O
possibly ADV O
due ADJ O
to ADP O
Yunnan PROPN O
’s PART O
position NOUN O
along ADP O
key ADJ O
heroin NOUN O
trafficking NOUN O
routes NOUN O
into ADP O
China PROPN O
[ PUNCT O
17 NUM O
, PUNCT O
18 NUM O
] PUNCT O
. PUNCT O

ICD PROPN B-AC
, PUNCT O
International PROPN B-LF
Classification PROPN I-LF
of ADP I-LF
Diseases PROPN I-LF
; PUNCT O
MS PROPN B-AC
, PUNCT O
multiple ADJ B-LF
sclerosis NOUN I-LF
; PUNCT O
RR PROPN B-AC
, PUNCT O
risk NOUN B-LF
ratio NOUN I-LF
. PUNCT O

IR PROPN O
, PUNCT O
infrared NOUN O
; PUNCT O
RGC PROPN B-AC
, PUNCT O
retinal ADJ B-LF
ganglion NOUN I-LF
cell NOUN I-LF
; PUNCT O
V PROPN B-AC
- PUNCT B-AC
DSGC PROPN B-AC
, PUNCT O
ventral ADJ B-LF
- PUNCT I-LF
preferring VERB I-LF
direction NOUN I-LF
selective ADJ I-LF
ganglion NOUN I-LF
cell NOUN I-LF
; PUNCT O
Vm PROPN O
, PUNCT O
membrane NOUN O
potential NOUN O
; PUNCT O
VME PROPN B-AC
, PUNCT O
visual ADJ B-LF
motion NOUN I-LF
experience NOUN I-LF
; PUNCT O
YFP PROPN O
, PUNCT O
yellow ADJ O
fluorescent ADJ O
protein NOUN O
. PUNCT O

And CCONJ O
the DET O
results NOUN O
of ADP O
western ADJ O
blot NOUN O
showed VERB O
that SCONJ O
Klf5 NOUN B-AC
expression NOUN O
in ADP O
ruptured VERB O
AAA PROPN B-AC
( PUNCT O
4 NUM O
cases NOUN O
) PUNCT O
was AUX O
significantly ADV O
lower ADJ O
than ADP O
that SCONJ O
in ADP O
unruptured ADJ O
AAA PROPN B-AC
( PUNCT O
22 NUM O
cases NOUN O
) PUNCT O
, PUNCT O
even ADV O
though SCONJ O
its PRON O
expression NOUN O
was AUX O
higher ADJ O
than ADP O
that SCONJ O
in ADP O
normal ADJ O
abdominal ADJ O
aorta NOUN O
( PUNCT O
8 NUM O
cases NOUN O
) PUNCT O
( PUNCT O
Fig PROPN O
1A NUM O
and CCONJ O
1B NUM O
) PUNCT O
. PUNCT O
Furthermore ADV O
, PUNCT O
confocal ADJ O
microscopy NOUN O
images NOUN O
were AUX O
obtained VERB O
by ADP O
immunofluorescence NOUN O
staining NOUN O
with ADP O
VSMC PROPN B-AC
marker NOUN O
( PUNCT O
smooth ADJ B-LF
muscle NOUN I-LF
α NOUN I-LF
- PUNCT I-LF
actin NOUN I-LF
, PUNCT O
SMA PROPN B-AC
) PUNCT O
and CCONJ O
Klf5 NOUN B-AC
, PUNCT O
and CCONJ O
showed VERB O
that SCONJ O
Klf5 NOUN B-AC
was AUX O
co VERB O
- PUNCT O
localized VERB O
with ADP O
VSMC PROPN B-AC
marker NOUN O
in ADP O
unruptured ADJ O
AAA PROPN B-AC
( PUNCT O
Fig PROPN O
1C NUM O
) PUNCT O
. PUNCT O
Moreover ADV O
, PUNCT O
Klf5 NOUN B-AC
- PUNCT O
positive ADJ O
VSMCs NOUN B-AC
were AUX O
hardly ADV O
observed VERB O
in ADP O
ruptured VERB O
AAA PROPN B-AC
, PUNCT O
while SCONJ O
the DET O
percentages NOUN O
of ADP O
Klf5 NOUN B-AC
- PUNCT O
positive ADJ O
VSMCs NOUN B-AC
were AUX O
significantly ADV O
higher ADJ O
in ADP O
unruptured ADJ O
AAA PROPN B-AC
than ADP O
in ADP O
the DET O
normal ADJ O
aorta NOUN O
( PUNCT O
10.3 NUM O
% NOUN O
± ADP O
2.2 NUM O
% NOUN O
versus ADP O
2.4 NUM O
% NOUN O
± ADP O
0.89 NUM O
% NOUN O
; NOUN O
Fig PROPN O
1C NUM O
and CCONJ O
1D NOUN O
) PUNCT O
. PUNCT O

Subsequently ADV O
, PUNCT O
a DET O
multivariate ADJ O
Bayesian ADJ B-LF
network NOUN I-LF
( PUNCT O
BN PROPN B-AC
, PUNCT O
using VERB O
the DET O
R PROPN O
package NOUN O
bnlearn PROPN O
) PUNCT O
[ X O
15 NUM O
] PUNCT O
was AUX O
constructed VERB O
to PART O
explore VERB O
the DET O
structural ADJ O
relationships NOUN O
between ADP O
variables NOUN O
; PUNCT O
BN PROPN B-AC
analysis NOUN O
determines VERB O
an DET O
optimal ADJ O
statistical ADJ O
description NOUN O
of ADP O
all DET O
the DET O
data NOUN O
as SCONJ O
it PRON O
considers VERB O
many ADJ O
possible ADJ O
model NOUN O
structures NOUN O
[ X O
16 NUM O
] PUNCT O
. PUNCT O

The DET O
connection NOUN O
between ADP O
the DET O
basal ADJ B-LF
ganglia NOUN I-LF
( PUNCT O
BG PROPN B-AC
) PUNCT O
and CCONJ O
one NUM O
of ADP O
its PRON O
major ADJ O
downstream ADJ O
targets NOUN O
, PUNCT O
the DET O
thalamus NOUN O
, PUNCT O
has AUX O
received VERB O
increased VERB O
attention NOUN O
recently ADV O
[ X O
1 NUM O
; PUNCT O
2 NUM O
; PUNCT O
3 NUM O
, PUNCT O
4 NUM O
; PUNCT O
5 NUM O
] X O
due ADP O
to ADP O
its PRON O
role NOUN O
as ADP O
a DET O
key ADJ O
pathway NOUN O
by ADP O
which PRON O
the DET O
BG PROPN B-AC
can AUX O
influence VERB O
cortical ADJ O
function NOUN O
. PUNCT O

Preeclampsia NOUN B-LF
( PUNCT O
PE NOUN B-AC
) PUNCT O
is AUX O
the DET O
most ADV O
frequently ADV O
encountered VERB O
severe ADJ O
complication NOUN O
during ADP O
pregnancy NOUN O
with ADP O
a DET O
clinical ADJ O
spectrum NOUN O
ranging VERB O
from ADP O
relatively ADV O
mild ADJ O
to ADP O
life NOUN O
- PUNCT O
threatening VERB O
[ PUNCT O
1 NUM O
, PUNCT O
2 NUM O
] PUNCT O
. PUNCT O

Difference NOUN B-LF
- PUNCT I-LF
in ADP I-LF
- PUNCT I-LF
differences NOUN I-LF
estimates NOUN I-LF
( PUNCT O
DDEs NOUN B-AC
) PUNCT O
of ADP O
impact NOUN O
were AUX O
calculated VERB O
, PUNCT O
adjusting VERB O
for ADP O
clustering NOUN O
. PUNCT O

We PRON O
gathered VERB O
male NOUN O
and CCONJ O
female ADJ O
RNA NOUN B-LF
sequencing NOUN I-LF
( PUNCT O
RNA NOUN B-AC
- ADJ B-AC
seq NOUN B-AC
) PUNCT O
data NOUN O
from ADP O
D. PROPN O
melanica PROPN O
and CCONJ O
D. PROPN O
robusta PROPN O
heads NOUN O
to PART O
test VERB O
whether SCONJ O
expression NOUN O
levels NOUN O
of ADP O
the DET O
newly ADV O
formed VERB O
neo ADJ O
- ADJ O
X ADJ O
chromosomes NOUN O
are AUX O
similar ADJ O
between ADP O
males NOUN O
and CCONJ O
females NOUN O
( PUNCT O
that ADV O
is AUX O
, PUNCT O
whether SCONJ O
they PRON O
have AUX O
evolved VERB O
dosage NOUN O
compensation NOUN O
) PUNCT O
. PUNCT O

In ADP O
our PRON O
initial ADJ O
analysis NOUN O
we PRON O
compared VERB O
a DET O
random ADJ B-LF
forest NOUN I-LF
( PUNCT O
RF NOUN B-AC
) PUNCT O
, PUNCT O
support NOUN B-LF
vector NOUN I-LF
machine NOUN I-LF
( PUNCT O
SVM PROPN B-AC
) PUNCT O
, PUNCT O
logistic ADJ B-LF
regression NOUN I-LF
( PUNCT O
LR NOUN B-AC
) PUNCT O
, PUNCT O
simple ADJ O
decision NOUN B-LF
tree NOUN I-LF
( PUNCT O
DT NOUN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
artificial ADJ O
neural ADJ O
network NOUN O
( PUNCT O
ANN PROPN O
) PUNCT O
model NOUN O
on ADP O
the DET O
entire ADJ O
feature NOUN O
set NOUN O
. PUNCT O

GS PROPN B-AC
was AUX O
pulled VERB O
down ADP O
with ADP O
GST PROPN O
- PUNCT O
glycogenin NOUN B-LF
— PUNCT O
GST PROPN O
- PUNCT O
GN(297–333)—fusion NOUN B-AC
protein NOUN O
before ADP O
and CCONJ O
after ADP O
α NOUN O
- PUNCT O
amylase NOUN O
digestion NOUN O
of ADP O
glycogen NOUN O
in ADP O
skeletal ADJ O
muscle NOUN O
extracts NOUN O
from ADP O
wild ADJ O
type NOUN O
( PUNCT O
RGL PROPN O
WT PROPN B-AC
) PUNCT O
and CCONJ O
RGL PROPN B-LF
knock ADJ I-LF
- PUNCT I-LF
in ADP I-LF
homozygous ADJ O
( PUNCT O
RGL PROPN B-AC
kin NOUN B-AC
hom NOUN O
) PUNCT O
mice NOUN O
. PUNCT O
( PUNCT O
A X O
) PUNCT O
GST PROPN O
- PUNCT O
GN(297–333 NUM B-AC
) PUNCT O
pulls VERB O
down ADP O
almost ADV O
all PRON O
GS PROPN B-AC
, PUNCT O
but CCONJ O
( PUNCT O
B NOUN O
) PUNCT O
neither CCONJ O
the DET O
WT PROPN B-AC
nor CCONJ O
the DET O
truncated VERB O
RGL PROPN O
( PUNCT O
RGL PROPN O
trunc NOUN O
) PUNCT O
was AUX O
pulled VERB O
down ADP O
by ADP O
GST PROPN O
- PUNCT O
GN(297–333 NUM B-AC
) PUNCT O
. PUNCT O

To PART O
assess VERB O
disease NOUN O
activity NOUN O
and CCONJ O
allow VERB O
comparison NOUN O
between ADP O
UC PROPN B-AC
( PUNCT O
Modified PROPN B-LF
Truelove PROPN I-LF
and CCONJ I-LF
Witts PROPN I-LF
activity NOUN I-LF
index NOUN I-LF
, PUNCT O
MTWAI PROPN B-AC
) PUNCT O
and CCONJ O
CD PROPN B-AC
( PUNCT O
Crohn PROPN O
’s PART O
disease NOUN O
activity NOUN O
index NOUN O
, PUNCT O
CDAI PROPN B-AC
) PUNCT O
, PUNCT O
disease NOUN O
activity NOUN O
measures NOUN O
were AUX O
normalized VERB O
to ADP O
a DET O
value NOUN O
between ADP O
0 NUM O
and CCONJ O
100 NUM O
and CCONJ O
expressed VERB O
as ADP O
an DET O
activity NOUN O
index NOUN O
. PUNCT O

BMI PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
creat NOUN B-AC
, PUNCT O
creatinine NOUN B-LF
; PUNCT O
cys NOUN B-AC
, PUNCT O
cystatin NOUN B-LF
C NOUN I-LF
; PUNCT O
creat NOUN B-AC
- PUNCT B-AC
cys NOUN B-AC
, PUNCT O
creatinine NOUN B-LF
and CCONJ I-LF
cystatin NOUN I-LF
C NOUN I-LF
; PUNCT O
CVD NOUN B-AC
, PUNCT O
cardiovascular ADJ B-LF
disease NOUN I-LF
; PUNCT O
DBP PROPN B-AC
, PUNCT O
diastolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
; PUNCT O
eGFR PROPN B-AC
, PUNCT O
estimated VERB B-LF
glomerular ADJ I-LF
filtration NOUN I-LF
rate NOUN I-LF
; PUNCT O
hsCRP PROPN B-AC
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
sensitivity NOUN I-LF
C NOUN I-LF
- PUNCT I-LF
reactive ADJ I-LF
protein NOUN I-LF
; PUNCT O
SBP PROPN B-AC
, PUNCT O
systolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
; PUNCT O
uACR PROPN B-AC
, PUNCT O
urine NOUN B-LF
albumin NOUN I-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
creatinine NOUN I-LF
ratio NOUN I-LF
. PUNCT O

Using VERB O
a DET O
single ADJ O
- PUNCT O
center NOUN O
prospective ADJ O
study NOUN O
design NOUN O
, PUNCT O
consecutive ADJ O
patients NOUN O
≥ VERB O
18 NUM O
years NOUN O
with ADP O
a DET O
diagnosis NOUN O
of ADP O
acute ADJ O
ischemic ADJ O
stroke NOUN O
/ SYM O
TIA NOUN B-AC
, PUNCT O
intracerebral ADJ B-LF
hemorrhage NOUN I-LF
( PUNCT O
ICH PROPN B-AC
) PUNCT O
, PUNCT O
or CCONJ O
subarachnoid ADJ B-LF
hemorrhage NOUN I-LF
( PUNCT O
SAH PROPN B-AC
) PUNCT O
were AUX O
consented VERB O
and CCONJ O
enrolled VERB O
in ADP O
the DET O
Northwestern PROPN O
University PROPN O
Brain PROPN O
Attack PROPN O
Registry PROPN O
. PUNCT O

The DET O
Reproductive PROPN B-LF
Life PROPN I-LF
Plan PROPN I-LF
( PUNCT O
RLP PROPN B-AC
) PUNCT O
is AUX O
a DET O
clinical ADJ O
tool NOUN O
to PART O
help VERB O
clients NOUN O
find VERB O
strategies NOUN O
to PART O
achieve VERB O
their PRON O
reproductive ADJ O
goals NOUN O
. PUNCT O

Dual ADJ B-AC
- PUNCT B-AC
LUC PROPN B-AC
, PUNCT O
transient ADJ B-LF
transcription NOUN I-LF
dual ADJ I-LF
- PUNCT I-LF
luciferase NOUN I-LF
assay NOUN I-LF
; PUNCT O
EBP1 PROPN B-AC
, PUNCT O
ErbB3 PROPN O
, PUNCT O
binding VERB O
protein NOUN O
1 NUM O
; PUNCT O
LUC PROPN O
, PUNCT O
luciferase NOUN O
; PUNCT O
REN PROPN O
, PUNCT O
Renilla PROPN O
luciferase NOUN O
; PUNCT O
RALF1 PROPN O
, PUNCT O
rapid ADJ O
alkalinization NOUN O
factor NOUN O
1 NUM O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
DS PROPN B-AC
, PUNCT O
diameter NOUN B-LF
stenosis NOUN I-LF
; PUNCT O
FFR PROPN B-AC
, PUNCT O
fractional ADJ B-LF
flow NOUN I-LF
reserve NOUN I-LF
; PUNCT O
LAD NOUN B-AC
, PUNCT O
left ADJ B-LF
anterior ADJ I-LF
descending NOUN I-LF
; PUNCT O
LCX NOUN B-AC
, PUNCT O
left ADJ B-LF
circumflex NOUN I-LF
; PUNCT O
MLD NOUN B-AC
, PUNCT O
minimal ADJ B-LF
lumen NOUN I-LF
diameter NOUN I-LF
; PUNCT O
RCA PROPN B-AC
, PUNCT O
right ADJ B-LF
coronary ADJ I-LF
artery NOUN I-LF
; PUNCT O
RLD NOUN B-AC
, PUNCT O
reference NOUN B-LF
lumen NOUN I-LF
diameter NOUN I-LF
. PUNCT O

Here ADV O
, PUNCT O
we PRON O
investigated VERB O
the DET O
role NOUN O
of ADP O
gut NOUN O
hormones NOUN O
, PUNCT O
pro ADJ O
- ADJ O
inflammatory ADJ O
cytokines NOUN O
and CCONJ O
single ADJ B-LF
nucleotide NOUN I-LF
polymorphisms NOUN I-LF
( PUNCT O
SNPs NOUN B-AC
) PUNCT O
associated VERB O
with ADP O
TLR NOUN B-AC
4p14 NUM O
in ADP O
H. PROPN O
pylori PROPN O
disease NOUN O
in ADP O
30 NUM O
subjects NOUN O
with ADP O
non ADJ B-LF
- ADJ I-LF
ulcer NOUN I-LF
dyspepsia NOUN I-LF
( PUNCT O
NUD PROPN B-AC
) PUNCT O
, PUNCT O
40 NUM O
with ADP O
peptic ADJ B-LF
ulcer NOUN I-LF
disease NOUN I-LF
( PUNCT O
PUD PROPN B-AC
) PUNCT O
and CCONJ O
15 NUM O
with ADP O
gastric ADJ B-LF
cancer NOUN I-LF
( PUNCT O
GC PROPN B-AC
) PUNCT O
subjects NOUN O
positive ADJ O
and CCONJ O
negative ADJ O
for ADP O
H. PROPN O
pylori PROPN O
infection NOUN O
. PUNCT O

AMI PROPN B-AC
, PUNCT O
acute ADJ B-LF
myocardial ADJ I-LF
infarction NOUN I-LF
; PUNCT O
CI PROPN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
IRR PROPN B-AC
, PUNCT O
incidence NOUN B-LF
rate NOUN I-LF
ratio NOUN I-LF
. PUNCT O

This DET O
study NOUN O
is AUX O
reported VERB O
following VERB O
the DET O
Strengthening VERB B-LF
the DET I-LF
Reporting PROPN I-LF
of ADP I-LF
Observational PROPN I-LF
Studies PROPN I-LF
in ADP I-LF
Epidemiology PROPN I-LF
( PUNCT O
STROBE PROPN B-AC
) PUNCT O
guidelines NOUN O
( PUNCT O
S1 PROPN O
STROBE PROPN B-AC
Checklist PROPN O
) PUNCT O
. PUNCT O

PGE2 PROPN B-AC
signaling NOUN O
is AUX O
of ADP O
particular ADJ O
interest NOUN O
given VERB O
that SCONJ O
( PUNCT O
1 X O
) PUNCT O
PGE2 PROPN B-AC
is AUX O
able ADJ O
to PART O
induce VERB O
decidualization NOUN O
via ADP O
cAMP NOUN B-AC
signaling NOUN O
in ADP O
human ADJ O
and CCONJ O
rodent ADJ O
ESFs PROPN B-AC
[ PUNCT O
12,14 NUM O
] PUNCT O
, PUNCT O
( PUNCT O
2 X O
) PUNCT O
the DET O
PGE2 PROPN B-AC
receptor NOUN O
PTGER4 PROPN O
is AUX O
widely ADV O
expressed VERB O
in ADP O
ESFs PROPN B-AC
in ADP O
mammals NOUN O
[ PUNCT O
16 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
( PUNCT O
3 X O
) PUNCT O
the DET O
recent ADJ O
finding NOUN O
that SCONJ O
prostaglandin NOUN B-LF
synthase NOUN I-LF
( PUNCT O
PTGS PROPN B-AC
, PUNCT O
also ADV O
known VERB O
as ADP O
“ PUNCT O
COX2 PROPN O
” PUNCT O
) PUNCT O
and CCONJ O
prostaglandin NOUN B-LF
E PROPN I-LF
synthase NOUN I-LF
( PUNCT O
PTGES PROPN B-AC
) PUNCT O
are AUX O
both PRON O
expressed VERB O
in ADP O
the DET O
opossum ADJ O
uterus NOUN O
after ADP O
embryo NOUN O
attachment NOUN O
[ PUNCT O
5 NUM O
] PUNCT O
. PUNCT O

While SCONJ O
LEP PROPN B-AC
in ADP O
this DET O
study NOUN O
perceived VERB O
psychological ADJ O
interventions NOUN O
as ADP O
contributing VERB O
to ADP O
their PRON O
well NOUN O
- PUNCT O
being NOUN O
, PUNCT O
a DET O
view NOUN O
in ADP O
line NOUN O
with ADP O
some DET O
other ADJ O
members NOUN O
of ADP O
LE PROPN B-AC
[ PUNCT O
6 NUM O
, PUNCT O
88 NUM O
] PUNCT O
, PUNCT O
it PRON O
is AUX O
not PART O
an DET O
opinion NOUN O
universally ADV O
held VERB O
within ADP O
the DET O
law NOUN B-LF
enforcement NOUN I-LF
literature NOUN O
. PUNCT O

Coomassie NOUN O
staining NOUN O
was AUX O
used VERB O
for ADP O
loading NOUN O
control NOUN O
. PUNCT O
( PUNCT O
D X O
and CCONJ O
E X O
) PUNCT O
Pearson PROPN O
regression NOUN O
analysis NOUN O
of ADP O
FMOD PROPN B-AC
mRNA NOUN O
and CCONJ O
( PUNCT O
D X O
) PUNCT O
left ADJ O
ventricular ADJ O
weight NOUN O
( PUNCT O
LVW)/tibia NOUN O
length NOUN O
, PUNCT O
or CCONJ O
( PUNCT O
E X O
) PUNCT O
lung NOUN O
weight NOUN O
( PUNCT O
LW)/tibia NOUN O
length NOUN O
in ADP O
sham- NOUN O
and CCONJ O
AB NOUN B-AC
- PUNCT O
operated VERB O
mice NOUN O
, PUNCT O
n NOUN O
= SYM O
87 NUM O
. PUNCT O
( PUNCT O
F X O
) PUNCT O
FMOD PROPN B-AC
, PUNCT O
lumican NOUN B-LF
( PUNCT O
LUM PROPN B-AC
) PUNCT O
, PUNCT O
biglycan NOUN B-LF
( PUNCT O
BGN PROPN B-AC
) PUNCT O
and CCONJ O
decorin NOUN B-LF
( PUNCT O
DCN PROPN B-AC
) PUNCT O
mRNA NOUN O
normalized VERB O
to ADP O
RPL32 PROPN O
in ADP O
LVs NOUN B-AC
of ADP O
mice NOUN O
24h-18w NUM O
post ADJ O
- PUNCT O
AB NOUN B-AC
, PUNCT O
relative ADJ O
to ADP O
the DET O
average NOUN O
of ADP O
sham NOUN O
- PUNCT O
operated VERB O
controls NOUN O
, PUNCT O
n NOUN O
sham NOUN O
= SYM O
3–10 NUM O
, PUNCT O
n NOUN O
AB NOUN B-AC
= SYM O
7–10 NUM O
. PUNCT O

iESR PROPN B-AC
, PUNCT O
induced VERB B-LF
- PUNCT I-LF
Environmental ADJ I-LF
Stress PROPN I-LF
Response PROPN I-LF
; PUNCT O
RP PROPN B-AC
, PUNCT O
ribosomal ADJ B-LF
protein NOUN I-LF
. PUNCT O

The DET O
cytokine NOUN O
profiles NOUN O
of ADP O
individual ADJ O
samples NOUN O
were AUX O
analyzed VERB O
with ADP O
t NOUN B-LF
- ADJ I-LF
distributed VERB I-LF
stochastic ADJ I-LF
neighbor NOUN I-LF
embedding NOUN I-LF
( PUNCT O
tSNE PROPN B-AC
) PUNCT O
[ X O
30 NUM O
] X O
implemented VERB O
in ADP O
R PROPN O
( PUNCT O
version NOUN O
3.2.3 NUM O
) PUNCT O
. PUNCT O

Fifty NUM O
- NOUN O
three NUM O
of ADP O
these DET O
subjects NOUN O
underwent VERB O
dual ADJ B-LF
energy NOUN I-LF
X NOUN I-LF
- NOUN I-LF
ray NOUN I-LF
absorptiometry NOUN I-LF
( PUNCT O
DXA PROPN B-AC
) PUNCT O
measurements NOUN O
of ADP O
adipose ADJ O
tissue NOUN O
mass NOUN O
and CCONJ O
distribution NOUN O
. PUNCT O

Microbial ADJ O
products NOUN O
are AUX O
largely ADV O
recognized VERB O
by ADP O
germ NOUN O
- PUNCT O
line NOUN O
encoded VERB O
innate ADJ O
immune ADJ O
sensors NOUN O
like ADJ O
toll NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
receptors NOUN I-LF
( PUNCT O
TLRs PROPN B-AC
) PUNCT O
. PUNCT O

On ADP O
- PUNCT O
track NOUN O
cognitive ADJ O
development NOUN O
was AUX O
associated VERB O
with ADP O
improved ADJ O
housing NOUN O
( PUNCT O
odds NOUN B-LF
ratio NOUN I-LF
[ PUNCT O
OR NOUN B-AC
] X O
= SYM O
1.15 NUM O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN O
1.06 NUM O
to PART O
1.24 NUM O
, PUNCT O
p NOUN O
< NOUN O
0.001 NUM O
) PUNCT O
, PUNCT O
improved ADJ O
drinking NOUN O
water NOUN O
( PUNCT O
OR NOUN B-AC
= SYM O
1.07 NUM O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN O
1.00 NUM O
to PART O
1.14 NUM O
, PUNCT O
p NOUN O
= SYM O
0.046 NUM O
) PUNCT O
, PUNCT O
improved ADJ O
sanitation NOUN O
facilities NOUN O
( PUNCT O
OR NOUN B-AC
= SYM O
1.15 NUM O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN O
1.03 NUM O
to PART O
1.28 NUM O
, PUNCT O
p NOUN O
= SYM O
0.014 NUM O
) PUNCT O
, PUNCT O
and CCONJ O
sufficient ADJ O
living NOUN O
area NOUN O
( PUNCT O
OR NOUN B-AC
= SYM O
1.06 NUM O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN O
1.01 NUM O
to PART O
1.10 NUM O
, PUNCT O
p NOUN O
= SYM O
0.018 NUM O
) PUNCT O
. PUNCT O

The DET O
amount NOUN O
of ADP O
nicked VERB O
product NOUN O
( PUNCT O
n NOUN O
) PUNCT O
and CCONJ O
linear ADJ O
product NOUN O
( PUNCT O
black ADJ O
triangle NOUN O
) PUNCT O
was AUX O
quantified VERB O
as ADP O
a DET O
fraction NOUN O
of ADP O
the DET O
total ADJ O
starting VERB O
closed VERB B-LF
circular ADJ I-LF
substrate NOUN I-LF
( PUNCT O
cc NOUN B-AC
) PUNCT O
. PUNCT O
( PUNCT O
B X O
) PUNCT O
Average NOUN O
of ADP O
three NUM O
separate ADJ O
experiments NOUN O
is AUX O
plotted VERB O
. PUNCT O

CI PROPN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
. PUNCT O

To ADP O
date NOUN O
, PUNCT O
many ADJ O
studies NOUN O
have AUX O
been AUX O
performed VERB O
, PUNCT O
and CCONJ O
thousands NOUN O
of ADP O
differentially ADV B-LF
expressed VERB I-LF
genes NOUN I-LF
( PUNCT O
DEGs NOUN B-AC
) PUNCT O
have AUX O
been AUX O
screened VERB O
. PUNCT O

However ADV O
, PUNCT O
as ADP O
an DET O
unsupervised ADJ O
topic NOUN O
model NOUN O
that PRON O
can AUX O
reflect VERB O
the DET O
continuous ADJ O
and CCONJ O
dynamic ADJ O
evolutional ADJ O
characteristics NOUN O
of ADP O
documents NOUN O
, PUNCT O
the DET O
dynamic ADJ B-LF
topic NOUN I-LF
model NOUN I-LF
( PUNCT O
DTM PROPN B-AC
) PUNCT O
is AUX O
also ADV O
adopted VERB O
by ADP O
many ADJ O
researchers NOUN O
. PUNCT O

White ADJ O
arrows NOUN O
indicate VERB O
conidia NOUN O
of ADP O
interest NOUN O
at ADP O
key ADJ O
points NOUN O
in ADP O
the DET O
transfer NOUN O
process NOUN O
. PUNCT O
cwh NOUN B-AC
, PUNCT O
A. NOUN O
fumigatus NOUN O
α NOUN O
- PUNCT O
glucosidase NOUN O
1 NUM O
; PUNCT O
gel NOUN B-AC
, PUNCT O
A. NOUN B-LF
fumigatus NOUN I-LF
β-1,3 NOUN I-LF
- PUNCT I-LF
glucanosyltransferase NOUN I-LF
. PUNCT O

Multivariate ADJ O
Cox PROPN O
proportional ADJ O
hazard NOUN O
analysis NOUN O
was AUX O
used VERB O
to PART O
estimate VERB O
the DET O
hazard NOUN B-LF
ratio NOUN I-LF
( PUNCT O
HR NOUN B-AC
) PUNCT O
of ADP O
CHD NOUN B-AC
and CCONJ O
mortality NOUN O
, PUNCT O
and CCONJ O
the DET O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
( PUNCT O
CI NOUN B-AC
) PUNCT O
among ADP O
H. PROPN B-AC
pylori NOUN B-AC
eradication NOUN O
, PUNCT O
non ADJ O
- ADJ O
H. PROPN B-AC
pylori NOUN B-AC
eradication NOUN O
, PUNCT O
early ADJ O
H. PROPN B-AC
pylori NOUN B-AC
eradication NOUN O
and CCONJ O
non ADJ O
- ADJ O
early ADJ O
H. PROPN B-AC
pylori NOUN B-AC
eradication NOUN O
groups NOUN O
. PUNCT O

GPi PROPN B-AC
, PUNCT O
globus NOUN B-LF
pallidus NOUN I-LF
- PUNCT I-LF
internus NOUN I-LF
; PUNCT O
VLa PROPN B-AC
, PUNCT O
ventrolateral ADJ B-LF
anterior ADJ I-LF
nucleus NOUN I-LF
. PUNCT O

Box NOUN O
and CCONJ O
whisker NOUN O
plots NOUN O
of ADP O
mRNA NOUN O
abundances NOUN O
of ADP O
PRA PROPN B-AC
and CCONJ O
PRB PROPN B-AC
, PUNCT O
ERα PROPN O
, PUNCT O
ERβ PROPN O
, PUNCT O
IL-8 NOUN B-AC
, PUNCT O
COX-2 NOUN B-AC
, PUNCT O
MnSOD PROPN B-AC
, PUNCT O
β2 NOUN B-LF
- ADJ I-LF
microglobulin NOUN I-LF
( PUNCT O
β2μ NOUN B-AC
) PUNCT O
, PUNCT O
connexin-43 NOUN B-LF
( PUNCT O
CX-43 NOUN B-AC
) PUNCT O
, PUNCT O
OTR PROPN B-AC
, PUNCT O
and CCONJ O
the DET O
homeobox NOUN O
gene NOUN O
HoxA10 PROPN O
in ADP O
labouring ADJ O
( PUNCT O
L NOUN O
) PUNCT O
and CCONJ O
non ADJ O
- ADJ O
labouring ADJ O
( PUNCT O
N NOUN O
) PUNCT O
women NOUN O
. PUNCT O

We PRON O
studied VERB O
two NUM O
population NOUN O
- PUNCT O
based VERB O
birth NOUN O
cohorts NOUN O
from ADP O
the DET O
UK PROPN O
: PUNCT O
the DET O
Avon PROPN B-LF
Longitudinal PROPN I-LF
Study PROPN I-LF
of ADP I-LF
Parents PROPN I-LF
and CCONJ I-LF
Children PROPN I-LF
( PUNCT O
ALSPAC PROPN B-AC
) PUNCT O
[ PUNCT O
35 NUM O
] PUNCT O
and CCONJ O
the DET O
Manchester PROPN B-LF
Asthma PROPN I-LF
and CCONJ I-LF
Allergy PROPN I-LF
Study PROPN I-LF
( PUNCT O
MAAS PROPN B-AC
) PUNCT O
[ PUNCT O
36 NUM O
] PUNCT O
. PUNCT O

Primer NOUN O
pairs NOUN O
for ADP O
plasminogen NOUN B-LF
activator NOUN I-LF
inhibitor NOUN I-LF
( PUNCT O
PAI)-1 PROPN B-AC
, PUNCT O
DNA NOUN O
methyltransferase NOUN O
( PUNCT O
DNMT PROPN O
) PUNCT O
-1 NUM O
, PUNCT O
-3a NOUN O
and CCONJ O
-3b NOUN O
, PUNCT O
fatty ADJ B-LF
acid NOUN I-LF
synthase NOUN I-LF
( PUNCT O
FAS PROPN B-AC
) PUNCT O
and CCONJ O
sphingosine NOUN B-LF
kinase NOUN I-LF
( PUNCT O
SPHK)-1 PROPN B-AC
were AUX O
designed VERB O
( PUNCT O
Table PROPN O
1 NUM O
) PUNCT O
. PUNCT O

GFP PROPN O
, PUNCT O
green ADJ O
fluorescent ADJ O
protein NOUN O
; PUNCT O
PA PROPN B-AC
, PUNCT O
protein NOUN B-LF
aggregate NOUN I-LF
; PUNCT O
TLFM PROPN B-AC
, PUNCT O
time NOUN B-LF
- PUNCT I-LF
lapse NOUN I-LF
fluorescence NOUN I-LF
microscopy NOUN I-LF
. PUNCT O

To PART O
identify VERB O
additional ADJ O
published VERB O
and CCONJ O
unpublished ADJ O
data NOUN O
, PUNCT O
we PRON O
contacted VERB O
experts NOUN O
in ADP O
the DET O
field NOUN O
of ADP O
pediatric ADJ O
MDR PROPN B-AC
- PROPN B-AC
TB PROPN B-AC
. PUNCT O
We PRON O
also ADV O
requested VERB O
data NOUN O
through ADP O
other ADJ O
routes NOUN O
, PUNCT O
including VERB O
at ADP O
national ADJ O
and CCONJ O
international ADJ O
conferences NOUN O
and CCONJ O
training NOUN O
events NOUN O
, PUNCT O
and CCONJ O
through ADP O
international ADJ O
and CCONJ O
in ADP O
- PROPN O
country NOUN O
organizations NOUN O
working VERB O
in ADP O
pediatric ADJ O
MDR PROPN B-AC
- PROPN B-AC
TB PROPN B-AC
, PUNCT O
including VERB O
the DET O
Sentinel PROPN O
Project PROPN O
on ADP O
Pediatric PROPN O
Drug PROPN O
- PROPN O
Resistant PROPN O
Tuberculosis PROPN B-LF
, PUNCT O
the DET O
WHO PROPN B-AC
Childhood PROPN O
TB PROPN B-AC
Sub PROPN O
- PROPN O
Group PROPN O
, PUNCT O
Médecins PROPN B-LF
Sans PROPN I-LF
Frontières PROPN I-LF
( PUNCT O
MSF PROPN B-AC
) PUNCT O
, PUNCT O
the DET O
United PROPN O
States PROPN O
Centers PROPN O
for ADP O
Disease PROPN O
Control PROPN O
and CCONJ O
Prevention PROPN O
( PUNCT O
CDC PROPN O
) PUNCT O
and CCONJ O
European PROPN B-LF
Centre PROPN I-LF
for ADP I-LF
Disease PROPN I-LF
Prevention PROPN I-LF
and CCONJ I-LF
Control PROPN I-LF
( PUNCT O
ECDC PROPN B-AC
) PUNCT O
, PUNCT O
The DET O
Union PROPN O
, PUNCT O
and CCONJ O
the DET O
National PROPN B-LF
Institutes PROPN I-LF
of ADP I-LF
Health PROPN I-LF
( PUNCT O
NIH PROPN B-AC
) PUNCT O
. PUNCT O

Additionally ADV O
, PUNCT O
textbooks NOUN O
addressing VERB O
the DET O
methodology NOUN O
of ADP O
clinical ADJ O
trials NOUN O
and CCONJ O
International PROPN B-LF
Conference PROPN I-LF
on ADP I-LF
Harmonisation PROPN I-LF
of ADP I-LF
Technical PROPN I-LF
Requirements PROPN I-LF
for ADP I-LF
Registration PROPN I-LF
of ADP I-LF
Pharmaceuticals PROPN I-LF
for ADP I-LF
Human PROPN I-LF
Use PROPN I-LF
( PUNCT O
ICH PROPN B-AC
) PUNCT O
tripartite ADJ O
guidelines NOUN O
for ADP O
clinical ADJ O
trials NOUN O
were AUX O
also ADV O
consulted VERB O
. PUNCT O

Effects NOUN O
of ADP O
norepinephrine NOUN B-LF
bitartrate NOUN I-LF
( PUNCT O
NB PROPN B-AC
) PUNCT O
treatment NOUN O
at ADP O
2 NUM O
dpf NOUN B-AC
for ADP O
24 NUM O
h NOUN O
on ADP O
the DET O
heartbeat NOUN O
( PUNCT O
A NOUN O
; PUNCT O
139.3±2.8 NUM O
/ SYM O
min NOUN O
in ADP O
control NOUN O
group NOUN O
, PUNCT O
166.3±2.1 NUM O
/ SYM O
min NOUN O
in ADP O
NT PROPN O
- PUNCT O
treated VERB O
group NOUN O
) PUNCT O
and CCONJ O
the DET O
average ADJ O
velocity NOUN O
of ADP O
midbrain NOUN O
blood NOUN O
flow NOUN O
( PUNCT O
B NOUN O
; PUNCT O
0.26±0.02 NUM O
mm NOUN O
/ SYM O
s NOUN O
in ADP O
control NOUN O
group NOUN O
, PUNCT O
0.38±0.04 NUM O
mm NOUN O
/ SYM O
s NOUN O
in ADP O
NT PROPN O
- PUNCT O
treated VERB O
group NOUN O
) PUNCT O
measured VERB O
at ADP O
3 NUM O
dpf NOUN B-AC
. PUNCT O

We PRON O
chose VERB O
to PART O
use VERB O
mesenchymal ADJ B-LF
stem NOUN I-LF
cells NOUN I-LF
( PUNCT O
MSCs PROPN B-AC
) PUNCT O
because SCONJ O
they PRON O
can AUX O
be AUX O
isolated VERB O
directly ADV O
from ADP O
transgenic ADJ O
mouse NOUN O
models NOUN O
of ADP O
interest NOUN O
and CCONJ O
are AUX O
highly ADV O
adipogenic ADJ O
[ PUNCT O
18 NUM O
] PUNCT O
. PUNCT O

BM PROPN B-AC
, PUNCT O
bone NOUN B-LF
marrow NOUN I-LF
. PUNCT O

We PRON O
examined VERB O
associations NOUN O
between ADP O
TBI PROPN B-AC
history NOUN O
and CCONJ O
MH PROPN B-AC
service NOUN O
utilization NOUN O
in ADP O
a DET O
subsample NOUN O
of ADP O
returning VERB O
veterans NOUN O
who PRON O
were AUX O
newly ADV O
diagnosed VERB O
with ADP O
posttraumatic ADJ B-LF
stress NOUN I-LF
disorder NOUN I-LF
( PUNCT O
PTSD PROPN B-AC
) PUNCT O
, PUNCT O
depression NOUN O
, PUNCT O
and/or CCONJ O
anxiety NOUN O
in ADP O
the DET O
2010 NUM O
fiscal ADJ O
year NOUN O
( PUNCT O
N NOUN O
= SYM O
55,458 NUM O
) PUNCT O
. PUNCT O

We PRON O
called VERB O
it PRON O
" PUNCT O
Innovative PROPN B-LF
Mobile PROPN I-LF
- PUNCT I-LF
phone PROPN I-LF
Technology PROPN I-LF
for ADP I-LF
Community PROPN I-LF
Health PROPN I-LF
Operations PROPN I-LF
" PUNCT O
( PUNCT O
ImTeCHO PROPN B-AC
) PUNCT O
[ X O
22,23 NUM O
] PUNCT O
. PUNCT O

ATCC PROPN B-AC
, PUNCT O
American PROPN B-LF
Type PROPN I-LF
Culture PROPN I-LF
Collection PROPN I-LF
; PUNCT O
NanA PROPN B-AC
, PUNCT O
N NOUN B-LF
- NOUN I-LF
acetylneuraminate NOUN I-LF
lyase NOUN I-LF
. PUNCT O

Fat PROPN B-LF
Free PROPN I-LF
Mass NOUN I-LF
equation NOUN O
: PUNCT O
FFM NOUN B-AC
= SYM O
Fat PROPN B-LF
Free PROPN I-LF
Mass NOUN I-LF
; PUNCT O
kg NOUN O
= SYM O
kilograms NOUN O
. PUNCT O

Langerhans PROPN B-LF
cell NOUN I-LF
histiocytosis NOUN I-LF
( PUNCT O
LCH PROPN B-AC
) PUNCT O
is AUX O
a DET O
rare ADJ O
clonal ADJ O
granulomatous ADJ O
disease NOUN O
that PRON O
affects VERB O
mainly ADV O
children NOUN O
. PUNCT O

The DET O
postoperative ADJ B-LF
IP PROPN B-AC
VEGF PROPN B-AC
- PUNCT B-AC
A PROPN B-AC
in ADP O
the DET O
major NOUN O
group NOUN O
was AUX O
significantly ADV O
elevated ADJ O
as ADP O
compared VERB O
to ADP O
the DET O
minor ADJ O
group NOUN O
( PUNCT O
median ADJ O
IP PROPN B-AC
VEGF PROPN B-AC
- PUNCT B-AC
A PROPN B-AC
× SYM O
106 NUM O
platelets NOUN O
: PUNCT O
POST PROPN B-AC
OP NOUN B-AC
major NOUN O
, PUNCT O
1.938 NUM O
pg NOUN O
; PUNCT O
POST PROPN B-AC
OP NOUN B-AC
minor ADJ O
, PUNCT O
0.786 NUM O
pg NOUN O
; PUNCT O
P<0.001 NUM O
) PUNCT O
. PUNCT O

BSI PROPN B-AC
, PUNCT O
bloodstream NOUN B-LF
infection NOUN I-LF
; PUNCT O
UTI NOUN B-AC
, PUNCT O
urinary ADJ B-LF
tract NOUN I-LF
infection NOUN I-LF
. PUNCT O

Seasonal ADJ O
modulation NOUN O
may AUX O
account VERB O
for ADP O
the DET O
observation NOUN O
that SCONJ O
some DET O
individuals NOUN O
with ADP O
mild ADJ B-LF
cognitive ADJ I-LF
impairment NOUN I-LF
( PUNCT O
MCI PROPN B-AC
) PUNCT O
subsequently ADV O
revert VERB O
to ADP O
normal ADJ O
cognition NOUN O
, PUNCT O
and CCONJ O
may AUX O
be AUX O
an DET O
important ADJ O
source NOUN O
of ADP O
diagnostic ADJ O
misclassification NOUN O
both CCONJ O
in ADP O
clinical ADJ O
trials NOUN O
and CCONJ O
in ADP O
clinical ADJ O
practice NOUN O
. PUNCT O

Underlying VERB O
data NOUN O
can AUX O
be AUX O
found VERB O
in ADP O
S1 PROPN O
Data PROPN O
. PUNCT O
5 NUM B-AC
- PUNCT B-AC
HT NOUN B-AC
, PUNCT O
serotonin NOUN B-LF
; PUNCT O
CV PROPN O
, PUNCT O
circumvallate NOUN O
; PUNCT O
HFD PROPN B-AC
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
fat NOUN I-LF
diet NOUN I-LF
; PUNCT O
KCNQ1 PROPN B-AC
, PUNCT O
potassium NOUN B-LF
voltage NOUN I-LF
- PUNCT I-LF
gated VERB I-LF
channel NOUN I-LF
subfamily NOUN I-LF
Q NOUN I-LF
member NOUN I-LF
1 NUM I-LF
; PUNCT O
Ki67 PROPN B-AC
, PUNCT O
Antigen NOUN B-LF
KI-67 PROPN I-LF
; PUNCT O
KO PROPN O
, PUNCT O
knockout NOUN O
; PUNCT O
NTPDase2 PROPN B-AC
, PUNCT O
ectonucleoside NOUN B-LF
triphosphate NOUN I-LF
diphosphohydrolase NOUN I-LF
2 NUM I-LF
; PUNCT O
PBS PROPN B-AC
, PUNCT O
phosphate NOUN B-LF
buffered VERB I-LF
saline NOUN I-LF
; PUNCT O
PLCβ2 PROPN B-AC
, PUNCT O
phospholipase NOUN B-LF
C NOUN I-LF
beta NOUN I-LF
2 NUM I-LF
; PUNCT O
SEM PROPN B-AC
, PUNCT O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean NOUN I-LF
; PUNCT O
TNFα PROPN B-AC
, PUNCT O
tumor NOUN B-LF
necrosis NOUN I-LF
factor NOUN I-LF
α NOUN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

To PART O
determine VERB O
BPD PROPN B-AC
diagnoses NOUN O
, PUNCT O
interviewers NOUN O
further ADV O
administered VERB O
the DET O
International PROPN O
Personality PROPN O
Disorder PROPN O
Examination PROPN O
[ PUNCT O
IPDE PROPN O
, PUNCT O
45 NUM O
] PUNCT O
and CCONJ O
the DET O
Zanarini PROPN O
Rating PROPN O
Scale PROPN O
for ADP O
Borderline PROPN B-LF
Personality PROPN I-LF
Disorder PROPN I-LF
[ PUNCT O
ZAN PROPN O
- PUNCT O
BPD PROPN B-AC
, PUNCT O
46 NUM O
] PUNCT O
. PUNCT O

The DET O
mannoside NOUN O
caps NOUN O
of ADP O
ManLAM PROPN O
in ADP O
MTB PROPN B-AC
may AUX O
be AUX O
further ADV O
substituted VERB O
with ADP O
a DET O
unique ADJ O
methylthio NOUN B-LF
- NOUN I-LF
D NOUN I-LF
- NOUN I-LF
xylose NOUN I-LF
( PUNCT O
MTX PROPN B-AC
) PUNCT O
residue NOUN O
[ PUNCT O
17 NUM O
] PUNCT O
. PUNCT O

Resistance NOUN O
to ADP O
tumor NOUN B-LF
necrosis NOUN I-LF
factor NOUN I-LF
- PUNCT I-LF
related VERB I-LF
apoptosis NOUN I-LF
- PUNCT I-LF
inducing VERB I-LF
ligand NOUN I-LF
( PUNCT O
TRAIL)-induced PROPN B-AC
apoptosis NOUN O
has AUX O
been AUX O
reported VERB O
in ADP O
some DET O
cancer NOUN O
cells NOUN O
, PUNCT O
including VERB O
AGS PROPN O
human ADJ O
gastric ADJ O
adenocarcinoma NOUN O
cells NOUN O
. PUNCT O

BV NOUN B-AC
, PUNCT O
biliverdin NOUN B-LF
; PUNCT O
OD NOUN O
, PUNCT O
optical ADJ O
density NOUN O
; PUNCT O
SEM NOUN B-AC
, PUNCT O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean NOUN I-LF
; PUNCT O
WT NOUN B-AC
, PUNCT O
wild ADJ B-LF
type NOUN I-LF
. PUNCT O

BPD NOUN B-AC
: PUNCT O
bronchopulmonary ADJ B-LF
dysplasia NOUN I-LF
; PUNCT O
CLD NOUN B-AC
: PUNCT O
chronic ADJ B-LF
lung NOUN I-LF
disease NOUN I-LF
; PUNCT O
CVL NOUN B-AC
: PUNCT O
central ADJ B-LF
venous ADJ I-LF
line NOUN I-LF
; PUNCT O
NEC NOUN B-AC
: PUNCT O
necrotizing VERB B-LF
enterocolitis NOUN I-LF
; PUNCT O
PDA NOUN B-AC
: PUNCT O
patent NOUN B-LF
ductus NOUN I-LF
arteriosus NOUN I-LF
; PUNCT O
SD NOUN B-AC
: PUNCT O
standard ADJ B-LF
deviation NOUN I-LF
; PUNCT O
WGA PROPN B-AC
: PUNCT O
weeks NOUN B-LF
of ADP I-LF
gestational ADJ I-LF
age NOUN I-LF
. PUNCT O

In ADP O
response NOUN O
to ADP O
the DET O
Earth PROPN O
’s PART O
predictable ADJ O
light NOUN B-LF
- PUNCT I-LF
dark ADJ I-LF
( PUNCT O
LD NOUN B-AC
) PUNCT O
cycles NOUN O
, PUNCT O
many ADJ O
organisms NOUN O
have AUX O
evolved VERB O
a DET O
circadian ADJ O
clock NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

In ADP O
contrast NOUN O
to ADP O
ESBL PROPN O
, PUNCT O
AmpC PROPN B-LF
beta NOUN I-LF
- NOUN I-LF
lactamase NOUN I-LF
activity NOUN O
is AUX O
not PART O
affected VERB O
by ADP O
ESBLs PROPN B-AC
inhibitors NOUN O
[ PUNCT O
11 NUM O
] PUNCT O
. PUNCT O

GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT O
UAS PROPN B-AC
, PUNCT O
upstream ADJ B-LF
activating VERB I-LF
sequence NOUN I-LF
. PUNCT O

HEK293 PROPN O
FT NOUN O
cells NOUN O
were AUX O
plated VERB O
on ADP O
poly ADJ O
- PUNCT O
d ADJ O
- PUNCT O
lysine NOUN O
coated VERB O
glass NOUN O
coverslips NOUN O
in ADP O
6 NUM O
well NOUN O
plates NOUN O
and CCONJ O
transfected VERB O
with ADP O
0.5 NUM O
g NOUN O
eYFP NOUN O
CAAX PROPN O
per ADP O
well NOUN O
using VERB O
polyethylenimine NOUN B-LF
( PUNCT O
PEI NOUN B-AC
) PUNCT O
at ADP O
a DET O
ratio NOUN O
of ADP O
1 NUM O
g NOUN O
DNA NOUN O
to ADP O
6 NUM O
g NOUN O
PEI NOUN B-AC
. PUNCT O
Prior ADV O
to ADP O
imaging NOUN O
, PUNCT O
cells NOUN O
were AUX O
treated VERB O
for ADP O
12 NUM O
h NOUN O
with ADP O
the DET O
NO PROPN B-AC
donor NOUN O
DETA PROPN O
- PUNCT O
NONOate PROPN O
or CCONJ O
a DET O
combination NOUN O
of ADP O
the DET O
farnesyl NOUN O
transferase NOUN O
inhibitor NOUN O
L-744,832 PROPN O
( PUNCT O
20 NUM O
μM NOUN O
) PUNCT O
and CCONJ O
the DET O
geranylgeranyltransferase NOUN O
I NOUN O
inhibitor NOUN O
GGTI-298 PROPN O
( PUNCT O
20 NUM O
μM NOUN O
) PUNCT O
. PUNCT O
Cells NOUN O
were AUX O
then ADV O
washed VERB O
3 NUM O
times NOUN O
with ADP O
PBS PROPN O
and CCONJ O
fixed VERB O
for ADP O
15 NUM O
min NOUN O
with ADP O
4 NUM O
% NOUN O
paraformaldehyde NOUN O
. PUNCT O

3D PROPN O
- PUNCT O
Fast PROPN O
Gray PROPN O
Matter PROPN O
Acquisition PROPN O
with ADP O
Phase PROPN O
Sensitive PROPN O
Inversion PROPN O
Recovery PROPN O
( PUNCT O
3D PROPN B-AC
- PUNCT B-AC
FGAPSIR PROPN B-AC
) PUNCT O
real ADV O
- PUNCT O
corrected VERB O
( PUNCT O
a DET O
) PUNCT O
and CCONJ O
second ADJ O
magnitude NOUN O
( PUNCT O
b NOUN O
) PUNCT O
images NOUN O
reformatted VERB O
in ADP O
the DET O
sagittal ADJ O
plane NOUN O
showing VERB O
a DET O
single ADJ O
left ADJ O
posterior ADJ O
cervical ADJ O
spinal ADJ O
cord NOUN O
lesion NOUN O
( PUNCT O
arrow NOUN O
) PUNCT O
, PUNCT O
whereas SCONJ O
no DET O
lesion NOUN O
was AUX O
detected VERB O
on ADP O
both CCONJ O
3D PROPN O
- PUNCT O
Short PROPN B-LF
- PUNCT I-LF
Tau PROPN I-LF
Inversion PROPN I-LF
Recovery PROPN I-LF
( PUNCT O
STIR PROPN B-AC
) PUNCT O
reformatted VERB O
in ADP O
the DET O
sagittal ADJ O
plane NOUN O
( PUNCT O
c NOUN O
) PUNCT O
or CCONJ O
sagittal ADJ O
T2 NOUN O
- PUNCT O
weighted VERB O
imaging NOUN O
( PUNCT O
d NOUN O
) PUNCT O
. PUNCT O
3D PROPN B-AC
- PUNCT B-AC
FGAPSIR PROPN B-AC
real ADV O
- PUNCT O
corrected VERB O
image NOUN O
reformatted VERB O
in ADP O
the DET O
axial ADJ O
plane NOUN O
( PUNCT O
e NOUN O
) PUNCT O
confirming VERB O
and CCONJ O
precisely ADV O
localizing VERB O
the DET O
lesion NOUN O
, PUNCT O
whereas SCONJ O
no DET O
lesion NOUN O
was AUX O
detected VERB O
on ADP O
3D PROPN O
- PUNCT O
STIR PROPN B-AC
reformatted VERB O
in ADP O
the DET O
axial ADJ O
plane NOUN O
( PUNCT O
f NOUN O
) PUNCT O
. PUNCT O

When SCONJ O
a DET O
log ADJ O
- ADJ O
linear ADJ O
model NOUN O
was AUX O
used VERB O
, PUNCT O
relative ADJ O
risk NOUN O
of ADP O
cancer NOUN O
per ADP O
10 NUM O
mGy NOUN O
of ADP O
in ADP O
utero NOUN O
dose NOUN O
was AUX O
0.99 NUM O
( PUNCT O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
( PUNCT O
CI NOUN B-AC
) PUNCT O
= SYM O
0.96 NUM O
to PART O
1.01 NUM O
) PUNCT O
based VERB O
on ADP O
incidence NOUN O
data NOUN O
and CCONJ O
0.98 NUM O
( PUNCT O
CI NOUN B-AC
= SYM O
0.94 NUM O
to PART O
1.01 NUM O
) PUNCT O
based VERB O
on ADP O
mortality NOUN O
data NOUN O
. PUNCT O

CI NOUN O
= PUNCT O
confidence NOUN O
interval NOUN O
; PUNCT O
hs NOUN O
- PUNCT O
cTnT NOUN O
= PUNCT O
high ADJ O
sensitivity NOUN O
cardiac ADJ O
Troponin NOUN O
- PUNCT O
T PROPN O
; PUNCT O
MACE NOUN B-AC
= PUNCT O
major ADJ B-LF
adverse ADJ I-LF
cardiac ADJ I-LF
events NOUN I-LF
; PUNCT O
ng NOUN O
/ SYM O
L NOUN O
= PUNCT O
nanograms NOUN O
per ADP O
liter NOUN O
; PUNCT O
OR NOUN O
= PUNCT O
odds NOUN O
ratio NOUN O
. PUNCT O

Trabecular ADJ B-LF
thickness NOUN I-LF
( PUNCT O
Tb NOUN B-AC
. PUNCT B-AC
Th NOUN B-AC
; PUNCT O
mm NOUN O
) PUNCT O
( PUNCT O
Fig NOUN O
2Ba NUM O
) PUNCT O
. PUNCT O

DS PROPN B-AC
, PUNCT O
dorsal ADJ B-LF
striatum NOUN I-LF
; PUNCT O
FR NOUN O
, PUNCT O
firing NOUN O
rate NOUN O
; PUNCT O
OFC PROPN B-AC
, PUNCT O
orbitofrontal ADJ B-LF
cortex NOUN I-LF
; PUNCT O
STE NOUN B-AC
, PUNCT O
standard ADJ B-LF
error NOUN I-LF
; PUNCT O
VS NOUN B-AC
, PUNCT O
ventral ADJ B-LF
striatum NOUN I-LF
. PUNCT O

CI PROPN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
FF PROPN B-AC
, PUNCT O
fresh ADV B-LF
frozen VERB I-LF
; PUNCT O
HR PROPN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT O
ICO PROPN B-AC
, PUNCT O
Catalan PROPN B-LF
Institute PROPN I-LF
of ADP I-LF
Oncology PROPN I-LF
; PUNCT O
TCR PROPN B-AC
, PUNCT O
T NOUN B-LF
- PUNCT I-LF
cell NOUN I-LF
receptor NOUN I-LF
. PUNCT O

In ADP O
fully ADV O
adjusted VERB O
models NOUN O
, PUNCT O
the DET O
As PROPN O
- PUNCT O
At+ PROPN O
( PUNCT O
β NOUN O
= SYM O
77.4 NUM O
μm NOUN O
, PUNCT O
95 NUM O
% NOUN O
confidence NOUN B-LF
intervals NOUN I-LF
[ PUNCT O
CI NOUN B-AC
] PUNCT O
, PUNCT O
10.3–144.5 NUM O
μm NOUN O
, PUNCT O
p NOUN O
= SYM O
0.02 NUM O
) PUNCT O
and CCONJ O
both DET O
asthmatic ADJ O
groups NOUN O
, PUNCT O
As+At- PROPN O
( PUNCT O
β NOUN O
= SYM O
64.2 NUM O
μm NOUN O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN B-AC
6.0–122.3 NUM O
μm NOUN O
, PUNCT O
p NOUN O
= SYM O
0.03 NUM O
) PUNCT O
and CCONJ O
As+At+ PROPN O
( PUNCT O
β NOUN O
= SYM O
85.8 NUM O
μm NOUN O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN B-AC
, PUNCT O
24.2–147.4 NUM O
μm NOUN O
, PUNCT O
p NOUN O
= SYM O
0.007 NUM O
) PUNCT O
had VERB O
significantly ADV O
thicker ADJ O
RCB NOUN B-AC
compared VERB O
to ADP O
the DET O
As PROPN O
- PUNCT O
At- PROPN O
participants NOUN O
. PUNCT O

Control ADJ O
human ADJ O
fibroblasts NOUN O
were AUX O
cultured VERB O
for ADP O
48 NUM O
hours NOUN O
on ADP O
glass NOUN O
coverslips NOUN O
then ADV O
treated VERB O
with ADP O
normal ADJ O
growth NOUN O
medium NOUN O
or CCONJ O
medium NOUN O
containing VERB O
2 NUM O
μg NOUN O
/ SYM O
ml NOUN O
brefeldin NOUN B-LF
A PROPN I-LF
( PUNCT O
BFA PROPN B-AC
) PUNCT O
for ADP O
120 NUM O
seconds NOUN O
. PUNCT O

Every DET O
year NOUN O
worldwide ADV O
, PUNCT O
4.8 NUM O
to ADP O
15.3 NUM O
per ADP O
million NUM O
persons NOUN O
with ADP O
autosomal ADJ B-LF
dominant ADJ I-LF
polycystic ADJ I-LF
kidney NOUN I-LF
disease NOUN I-LF
( PUNCT O
ADPKD PROPN B-AC
) PUNCT O
progress VERB O
to ADP O
end ADJ B-LF
- ADJ I-LF
stage NOUN I-LF
renal ADJ I-LF
disease NOUN I-LF
( PUNCT O
ESRD PROPN B-AC
) PUNCT O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

The DET O
homogenates NOUN O
were AUX O
used VERB O
for ADP O
the DET O
estimation NOUN O
of ADP O
superoxide NOUN B-LF
dismutase NOUN I-LF
( PUNCT O
SOD PROPN B-AC
) PUNCT O
, PUNCT O
total ADJ O
antioxidant ADJ O
capacity NOUN O
( PUNCT O
MDA PROPN B-AC
) PUNCT O
, PUNCT O
MCP1 PROPN B-AC
, PUNCT O
TNF PROPN O
- PUNCT O
α PROPN O
, PUNCT O
HSP70 PROPN B-AC
, PUNCT O
Bax PROPN B-AC
, PUNCT O
PLCγ PROPN B-AC
and CCONJ O
ERK1/2protein NOUN O
expression NOUN O
by ADP O
enzyme NOUN B-LF
- PUNCT I-LF
linked VERB I-LF
immunosorbent NOUN I-LF
assay NOUN I-LF
( PUNCT O
ELISA PROPN B-AC
) PUNCT O
( PUNCT O
R&D PROPN O
Sys PROPN O
. PUNCT O
, PUNCT O
USA PROPN O
) PUNCT O
according VERB O
to ADP O
the DET O
manufacturer NOUN O
’s PART O
protocol NOUN O
. PUNCT O

Liver NOUN B-LF
function NOUN I-LF
tests NOUN I-LF
( PUNCT O
LFTs NOUN B-AC
) PUNCT O
are AUX O
commonly ADV O
used VERB O
in ADP O
clinic NOUN O
approaching VERB O
hepatobiliary ADJ O
disease NOUN O
. PUNCT O

The DET O
amino ADJ O
acid NOUN O
sequence NOUN O
of ADP O
Vibrio PROPN B-LF
harveyi PROPN I-LF
β NOUN I-LF
- NOUN I-LF
N NOUN I-LF
- NOUN I-LF
acetylglucosaminidase NOUN I-LF
, PUNCT O
VhGlcNAcase PROPN B-AC
( PUNCT O
SwissProt PROPN O
: PUNCT O
D9ISE0 PROPN O
) PUNCT O
was AUX O
retrieved VERB O
from ADP O
the DET O
Uniprot PROPN O
database NOUN O
. PUNCT O

FS PROPN B-AC
( PUNCT O
50 NUM O
μM NOUN O
, PUNCT O
5 NUM O
min)-induced NOUN O
phosphorylation NOUN O
of ADP O
CPEB3a PROPN O
was AUX O
prevented VERB O
by ADP O
pre NOUN O
- PUNCT O
treatment NOUN O
with ADP O
H89 NOUN O
( PUNCT O
10 NUM O
μM NOUN O
) PUNCT O
or CCONJ O
RP NOUN O
- PUNCT O
cAMPS NOUN O
( PUNCT O
100 NUM O
μM NOUN O
) PUNCT O
. PUNCT O
Treatment NOUN O
with ADP O
okadaic NOUN B-LF
acid NOUN I-LF
( PUNCT O
OA PROPN B-AC
) PUNCT O
( PUNCT O
0.3 NUM O
μM NOUN O
) PUNCT O
, PUNCT O
a DET O
PP1 NOUN O
/ SYM O
PP2A PROPN O
/ SYM O
PP2B NOUN O
inhibitor NOUN O
[ PUNCT O
43 NUM O
] PUNCT O
, PUNCT O
led VERB O
to ADP O
a DET O
significant ADJ O
increase NOUN O
in ADP O
phosphorylated VERB O
CPEB3 NOUN O
, PUNCT O
which PRON O
was AUX O
further ADV O
increased VERB O
when SCONJ O
combined VERB O
with ADP O
FS PROPN B-AC
treatment NOUN O
( PUNCT O
5 NUM O
min NOUN O
) PUNCT O
( PUNCT O
Fig PROPN O
5C NUM O
and CCONJ O
5D NUM O
, PUNCT O
p<0.05 NUM O
) PUNCT O
. PUNCT O

Random ADJ B-LF
barcode NOUN I-LF
transposon NOUN I-LF
site NOUN I-LF
sequencing NOUN I-LF
( PUNCT O
RB PROPN B-AC
- PUNCT B-AC
TnSeq PROPN B-AC
) PUNCT O
allows VERB O
genome NOUN O
- PUNCT O
wide ADJ O
insertion NOUN O
mutagenesis NOUN O
leading VERB O
to ADP O
LOF PROPN B-AC
mutations NOUN O
[ PUNCT O
64 NUM O
] PUNCT O
; PUNCT O
a DET O
pooled VERB O
CRISPR NOUN B-LF
interference NOUN I-LF
( PUNCT O
CRISPRi PROPN B-AC
) PUNCT O
approach NOUN O
, PUNCT O
which PRON O
allows VERB O
partial ADJ O
inhibition NOUN O
of ADP O
gene NOUN O
function NOUN O
via ADP O
transcriptional ADJ O
inhibition NOUN O
[ PUNCT O
65 NUM O
] PUNCT O
; PUNCT O
and CCONJ O
dual ADJ B-LF
- PUNCT I-LF
barcoded ADJ I-LF
shotgun NOUN I-LF
expression NOUN I-LF
library NOUN I-LF
sequencing NOUN I-LF
( PUNCT O
Dub PROPN B-AC
- PUNCT B-AC
seq NOUN B-AC
) PUNCT O
[ PUNCT O
66 NUM O
] PUNCT O
, PUNCT O
which PRON O
queries VERB O
the DET O
effects NOUN O
of ADP O
gene NOUN O
overexpression NOUN O
. PUNCT O

The DET O
vectors NOUN O
of ADP O
Aβ NOUN B-AC
1–40 NUM O
scrambled ADJ B-LF
sequence NOUN O
( PUNCT O
SCR NOUN B-AC
) PUNCT O
and CCONJ O
Aβ NOUN B-AC
1–40 NUM O
scrambled ADJ B-LF
sequence NOUN O
1–16 NUM O
( PUNCT O
NSCR PROPN B-AC
) PUNCT O
in ADP O
pET-30a(+ NOUN O
) PUNCT O
were AUX O
purchased VERB O
from ADP O
GenScript PROPN O
and CCONJ O
the DET O
peptides NOUN O
were AUX O
expressed VERB O
in ADP O
Escherichia PROPN O
coli NOUN O
and CCONJ O
then ADV O
purified VERB O
by ADP O
HPLC PROPN O
as SCONJ O
described VERB O
previously ADV O
[ PUNCT O
47 NUM O
] PUNCT O
. PUNCT O

( PUNCT O
A X O
) PUNCT O
Standard ADJ O
histology NOUN O
immunostaining NOUN O
for ADP O
high ADJ O
molecular ADJ O
weight NOUN O
cytokeratins NOUN O
and CCONJ O
p63 NOUN O
( PUNCT O
basal ADJ O
cell NOUN O
markers NOUN O
in ADP O
brown ADJ O
) PUNCT O
and CCONJ O
α NOUN O
- PUNCT O
methylacyl NOUN O
- PUNCT O
CoA NOUN O
racemase NOUN O
( PUNCT O
cancer NOUN O
cell NOUN O
marker NOUN O
in ADP O
red ADJ O
) PUNCT O
, PUNCT O
followed VERB O
by ADP O
hematoxylin NOUN B-LF
and CCONJ I-LF
eosin NOUN I-LF
( PUNCT O
H&E PROPN B-AC
) PUNCT O
counterstaining VERB O
to PART O
identify VERB O
intraductal ADJ B-LF
carcinoma NOUN I-LF
of ADP I-LF
the DET I-LF
prostate NOUN I-LF
( PUNCT O
IDC PROPN B-AC
- PUNCT B-AC
P PROPN B-AC
) PUNCT O
along ADP O
with ADP O
adjacent ADJ O
cancer NOUN O
and CCONJ O
prostate NOUN O
cancer NOUN O
without ADP O
IDC PROPN B-AC
- PUNCT B-AC
P. PUNCT O

Institutions NOUN O
such ADJ O
as ADP O
the DET O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT O
WHO PROPN B-AC
) PUNCT O
, PUNCT O
United PROPN B-LF
Nations PROPN I-LF
International PROPN I-LF
Children PROPN I-LF
’s PART I-LF
Emergency PROPN I-LF
Fund PROPN I-LF
( PUNCT O
UNICEF PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
the DET O
World PROPN O
Bank PROPN O
now ADV O
advocate VERB O
filling VERB O
this DET O
gap NOUN O
via ADP O
collection NOUN O
and CCONJ O
sharing NOUN O
of ADP O
program NOUN O
cost NOUN O
data NOUN O
from ADP O
evaluations NOUN O
of ADP O
ECD PROPN B-AC
interventions NOUN O
in ADP O
LMIC PROPN B-AC
settings NOUN O
[ PUNCT O
9 NUM O
] PUNCT O
. PUNCT O

On ADP O
multivariate ADJ O
analysis NOUN O
, PUNCT O
≥2 NUM O
TACE PROPN B-AC
procedures NOUN O
within ADP O
6 NUM O
months NOUN O
( PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
[ X O
HR NOUN B-AC
] X O
= SYM O
1.898 NUM O
) PUNCT O
, PUNCT O
and CCONJ O
the DET O
des ADJ O
- PUNCT O
gamma NOUN O
carboxyprothrombin NOUN O
level NOUN O
( PUNCT O
HR NOUN B-AC
= SYM O
1.000 NUM O
) PUNCT O
independently ADV O
predicted VERB O
the DET O
progression NOUN O
to ADP O
Barcelona PROPN B-LF
Clinic PROPN I-LF
Liver PROPN I-LF
Cancer PROPN I-LF
( PUNCT O
BCLC PROPN B-AC
) PUNCT O
stage NOUN O
C PROPN O
in ADP O
patients NOUN O
with ADP O
BCLC PROPN B-AC
stage NOUN O
0 NUM O
- PUNCT O
B NOUN O
HCC PROPN B-AC
( PUNCT O
both PRON O
P<0.05 NUM O
) PUNCT O
. PUNCT O

Odds NOUN B-LF
ratios NOUN I-LF
( PUNCT O
ORs NOUN B-AC
) PUNCT O
were AUX O
estimated VERB O
with ADP O
logistic ADJ O
regression NOUN O
. PUNCT O

* PUNCT O
ROSC PROPN B-AC
indicates VERB O
return NOUN B-LF
of ADP I-LF
spontaneous ADJ I-LF
circulation NOUN I-LF
. PUNCT O

Finally ADV O
, PUNCT O
our PRON O
study NOUN O
aims VERB O
to PART O
resolve VERB O
conflicting VERB O
evidence NOUN O
on ADP O
the DET O
impact NOUN O
of ADP O
gender NOUN O
, PUNCT O
age NOUN O
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT O
BMI PROPN B-AC
) PUNCT O
, PUNCT O
daytime ADJ B-LF
sleepiness NOUN I-LF
( PUNCT O
DS PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
comorbid ADJ O
CV PROPN B-AC
disease NOUN O
on ADP O
the DET O
strength NOUN O
of ADP O
association NOUN O
between ADP O
OSA PROPN B-AC
and CCONJ O
development NOUN O
of ADP O
CV PROPN B-AC
outcomes NOUN O
. PUNCT O

BMI PROPN B-AC
= PUNCT O
Body NOUN B-LF
Mass NOUN I-LF
Index NOUN I-LF
, PUNCT O
WC PROPN B-AC
= PUNCT O
Waist NOUN B-LF
Circumference NOUN I-LF
, PUNCT O
BP NOUN O
= PUNCT O
Blood NOUN O
Pressure NOUN O
, PUNCT O
Sys PROPN O
= PUNCT O
Systolic NOUN O
, PUNCT O
Dia NOUN O
= PUNCT O
Diastolic NOUN O
, PUNCT O
HbA1c NOUN B-AC
= PUNCT O
Glycated VERB B-LF
Hemoglobin NOUN I-LF
A1c NOUN O
, PUNCT O
FPG PROPN B-AC
= PUNCT O
Fasting NOUN B-LF
Plasma NOUN I-LF
Glucose NOUN I-LF
, PUNCT O
TC PROPN B-AC
= PUNCT O
Total ADJ B-LF
Cholesterol NOUN I-LF
, PUNCT O
TG NOUN B-AC
= PUNCT O
Triglycerides NOUN B-LF
, PUNCT O
HDL PROPN B-AC
- PUNCT B-AC
Chol PROPN B-AC
= PUNCT O
High ADJ O
Density NOUN O
Liporpotein NOUN O
Cholesterol NOUN O
, PUNCT O
LDL PROPN O
- PUNCT O
C PROPN O
= PUNCT O
Low ADJ O
Density NOUN O
Lipoprotein NOUN O
Cholesterol NOUN O
, PUNCT O
LTL PROPN B-AC
= PUNCT O
Leukocyte NOUN B-LF
Telomere PROPN I-LF
Length PROPN I-LF
, PUNCT O
hTERT NOUN B-AC
= PUNCT O
Human PROPN B-LF
Telomerase PROPN I-LF
Reverse PROPN I-LF
Transcriptase PROPN I-LF
. PUNCT O

Moreover ADV O
their PRON O
endocytic ADJ O
capacities NOUN O
make VERB O
them PRON O
effective ADJ O
scavengers NOUN O
for ADP O
molecules NOUN O
such ADJ O
as ADP O
albumin NOUN O
, PUNCT O
acetylated VERB B-LF
low ADJ I-LF
- NOUN I-LF
density NOUN I-LF
lipoproteins NOUN I-LF
( PUNCT O
Ac NOUN B-AC
- NOUN B-AC
LDL PROPN B-AC
) PUNCT O
and CCONJ O
antigens NOUN O
in ADP O
the DET O
bloodstream NOUN O
[ PUNCT O
1 NUM O
, PUNCT O
2 NUM O
] PUNCT O
. PUNCT O

Discriminant PROPN B-LF
Function PROPN I-LF
Analysis PROPN I-LF
( PUNCT O
DFA PROPN B-AC
) PUNCT O
, PUNCT O
also ADV O
known VERB O
as ADP O
Linear PROPN B-LF
Discriminant PROPN I-LF
Analysis PROPN I-LF
( PUNCT O
LDA PROPN B-AC
) PUNCT O
, PUNCT O
is AUX O
a DET O
statistical ADJ O
analysis NOUN O
which PRON O
works VERB O
to PART O
attain VERB O
the DET O
maximum ADJ O
discrimination NOUN O
between ADP O
classes NOUN O
. PUNCT O

C X B-AC
- PUNCT B-AC
statistic NOUN B-AC
, PUNCT O
concordance NOUN B-LF
statistic NOUN I-LF
. PUNCT O

APR PROPN B-AC
, PUNCT O
apical ADJ B-LF
polar ADJ I-LF
ring NOUN I-LF
; PUNCT O
HA PROPN O
, PUNCT O
hemagglutinin NOUN O
; PUNCT O
SAS6L PROPN B-AC
, PUNCT O
SAS6 NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
. PUNCT O

As ADP O
a DET O
consequence NOUN O
of ADP O
their PRON O
dimer ADJ O
polarity NOUN O
, PUNCT O
they PRON O
contain VERB O
plus ADJ O
and CCONJ O
minus ADJ O
ends NOUN O
, PUNCT O
with ADP O
plus ADJ O
ends NOUN O
representing VERB O
the DET O
growing NOUN O
ends NOUN O
that PRON O
associate VERB O
with ADP O
microtubule NOUN O
plus ADJ O
- PUNCT O
end NOUN O
tracking NOUN O
proteins NOUN O
( PUNCT O
+ PUNCT O
TIPs PROPN O
) PUNCT O
( PUNCT O
end NOUN B-LF
- PUNCT I-LF
binding VERB I-LF
protein NOUN I-LF
3 NUM I-LF
[ PUNCT O
EB3 PROPN B-AC
] PUNCT O
, PUNCT O
among ADP O
others NOUN O
) PUNCT O
[ PUNCT O
15 NUM O
] PUNCT O
. PUNCT O

RA PROPN B-AC
, PUNCT O
robust ADJ B-LF
nucleus NOUN I-LF
of ADP I-LF
the DET I-LF
arcopallium NOUN I-LF
. PUNCT O

BSA PROPN B-AC
, PUNCT O
bovine ADJ B-LF
serum NOUN I-LF
albumin NOUN I-LF
; PUNCT O
Fc PROPN B-AC
, PUNCT O
fragment NOUN B-LF
crystallizable ADJ I-LF
; PUNCT O
PMN PROPN B-AC
, PUNCT O
polymorphonuclear ADJ B-LF
cell NOUN I-LF
. PUNCT O

In ADP O
this DET O
study NOUN O
, PUNCT O
we PRON O
identified VERB O
the DET O
PY PROPN B-AC
- ADJ B-AC
NLS PROPN B-AC
located VERB O
in ADP O
the DET O
N NOUN O
- ADJ O
terminal ADJ O
region NOUN O
of ADP O
Gli PROPN O
proteins NOUN O
as ADP O
a DET O
ciliary NOUN B-LF
localization NOUN I-LF
signal NOUN I-LF
( PUNCT O
CLS PROPN B-AC
) PUNCT O
whose DET O
mutation NOUN O
diminished VERB O
Gli PROPN O
ciliary NOUN O
localization NOUN O
. PUNCT O

RR PROPN B-AC
, PUNCT O
risk NOUN B-LF
ratio NOUN I-LF
; PUNCT O
VL PROPN B-AC
, PUNCT O
viral ADJ B-LF
load NOUN I-LF
. PUNCT O

GaTP PROPN B-AC
: PUNCT O
Gallium(III NOUN B-LF
) PUNCT I-LF
meso NOUN I-LF
tetraphenylporphyrine NOUN I-LF
chloride NOUN I-LF
; PUNCT O
GaNP PROPN B-AC
: PUNCT O
nanoparticle NOUN O
encapsulating VERB O
GaTP PROPN B-AC
; PUNCT O
GaF PROPN B-AC
: PUNCT O
folate NOUN O
- PUNCT O
conjugated VERB O
nanoparticles NOUN O
encapsulating VERB O
GaTP PROPN B-AC
; PUNCT O
GaM PROPN B-AC
: PUNCT O
mannose NOUN O
- PUNCT O
conjugated VERB O
nanoparticles NOUN O
encapsulating VERB O
GaTP PROPN B-AC
; PUNCT O
RifD PROPN B-AC
: PUNCT O
dendrimer NOUN O
nanoparticle NOUN O
encapsulating VERB O
rifampin NOUN O
; PUNCT O
and CCONJ O
RifNP PROPN O
: PUNCT O
P118 NOUN O
nanoparticle NOUN O
encapsulating VERB O
rifampin NOUN O
. PUNCT O

Plastins NOUN O
are AUX O
a DET O
family NOUN O
of ADP O
three NUM O
tissue NOUN O
- PUNCT O
specific ADJ O
actin NOUN B-LF
- PUNCT I-LF
binding VERB I-LF
proteins NOUN I-LF
( PUNCT O
ABPs PROPN B-AC
) PUNCT O
. PUNCT O

Delong PROPN O
test NOUN O
showed VERB O
that SCONJ O
the DET O
combined VERB O
model NOUN O
had VERB O
the DET O
best ADJ O
diagnostic ADJ O
performance NOUN O
: PUNCT O
area NOUN B-LF
under ADP I-LF
the DET I-LF
curve NOUN I-LF
( PUNCT O
AUC NOUN B-AC
) PUNCT O
, PUNCT O
0.972 NUM O
( PUNCT O
95 NUM O
% NOUN O
CI NOUN O
[ NUM O
0.947–0.997 NUM O
] PUNCT O
) PUNCT O
in ADP O
the DET O
training NOUN O
cohort NOUN O
and CCONJ O
0.979 NUM O
( PUNCT O
95 NUM O
% NOUN O
CI NOUN O
[ NUM O
0.952–1 NUM O
] PUNCT O
) PUNCT O
in ADP O
the DET O
validation NOUN O
cohort NOUN O
. PUNCT O

Imaging NOUN O
allows VERB O
for ADP O
differentiation NOUN O
between ADP O
hemorrhagic ADJ O
and CCONJ O
ischemic ADJ O
stroke NOUN O
, PUNCT O
reveals VERB O
extend NOUN O
of ADP O
the DET O
ischemia NOUN O
and CCONJ O
allows VERB O
reliable ADJ O
patient NOUN O
selection NOUN O
for ADP O
intra ADJ B-LF
- PUNCT I-LF
arterial ADJ I-LF
therapy NOUN I-LF
( PUNCT O
IAT PROPN B-AC
) PUNCT O
treatment NOUN O
( PUNCT O
clot NOUN O
formation NOUN O
and CCONJ O
location NOUN O
, PUNCT O
stenosis NOUN O
and CCONJ O
infarct NOUN O
- PUNCT O
area NOUN O
) PUNCT O
. PUNCT O
[ X O
3 X O
] X O
As SCONJ O
IAT PROPN B-AC
recently ADV O
has AUX O
been AUX O
shown VERB O
to PART O
be AUX O
beneficial ADJ O
in ADP O
acute ADJ O
ischemic ADJ O
stroke NOUN O
caused VERB O
by ADP O
proximal ADJ O
intracranial ADJ O
anterior ADJ O
circulation NOUN O
occlusion NOUN O
, PUNCT O
the DET O
role NOUN O
of ADP O
imaging NOUN O
is AUX O
even ADV O
more ADV O
essential ADJ O
. PUNCT O
[ X O
4–8 X O
] X O

Chronic ADJ O
obstructive ADJ O
pulmonary ADJ O
disease NOUN O
= PUNCT O
chronic ADJ O
pulmonary ADJ O
obstructive ADJ O
disease NOUN O
or CCONJ O
bronchial ADJ O
asthma NOUN O
; PUNCT O
IQR PROPN O
= PUNCT O
interquartile ADJ O
range NOUN O
; PUNCT O
ICU PROPN B-AC
= PUNCT O
intensive ADJ B-LF
care NOUN I-LF
unit NOUN I-LF
; PUNCT O
BMI PROPN O
= PUNCT O
body NOUN O
mass NOUN O
index NOUN O
; PUNCT O
PaO2 PROPN O
/ SYM O
FiO2 PROPN O
= PUNCT O
arterial ADJ O
pressure NOUN O
of ADP O
oxygen NOUN O
/ SYM O
fraction NOUN O
of ADP O
inspired VERB O
oxygen NOUN O
; PUNCT O
Duration NOUN O
of ADP O
Mechanical ADJ O
ventilation NOUN O
= PUNCT O
time NOUN O
from ADP O
intubation NOUN O
to ADP O
extubation NOUN O
/ SYM O
decannulation NOUN O
or CCONJ O
pressure NOUN O
support NOUN O
of ADP O
or CCONJ O
below ADP O
5 NUM O
cm NOUN O
H2O NOUN O
for ADP O
at ADV O
least ADV O
24h NUM O
; PUNCT O
ECMO PROPN B-AC
= PUNCT O
extracorporeal ADJ B-LF
membrane NOUN I-LF
oxygenation NOUN I-LF
; PUNCT O
CVVHD PROPN O
= PUNCT O
continuous ADJ O
venous ADJ O
- PUNCT O
venous ADJ O
hemodialysis NOUN O

G NOUN B-LF
- PUNCT I-LF
protein NOUN I-LF
- PUNCT I-LF
couple NOUN I-LF
receptor NOUN I-LF
, PUNCT I-LF
family NOUN I-LF
C PROPN I-LF
, PUNCT I-LF
group NOUN I-LF
5 NUM I-LF
member NOUN I-LF
A PROPN I-LF
( PUNCT O
GPRC5A PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
was AUX O
identified VERB O
as ADP O
an DET O
all PRON O
- PUNCT O
trans ADJ O
- PUNCT O
retinoic ADJ O
acid NOUN O
- PUNCT O
inducible ADJ O
protein NOUN O
, PUNCT O
is AUX O
a DET O
member NOUN O
of ADP O
class NOUN O
c NUM O
orphan NOUN O
GPCRs PROPN B-AC
. PUNCT O
GPRC5A PROPN B-AC
, PUNCT O
also ADV O
known VERB O
as ADP O
RAI3 PROPN B-AC
or CCONJ O
RAIG1 PROPN B-AC
, PUNCT O
can AUX O
activate VERB O
numerous ADJ O
signal NOUN O
transduction NOUN O
cascades NOUN O
, PUNCT O
including VERB O
the DET O
NF PROPN O
- PUNCT O
κB PROPN O
, PUNCT O
cAMP PROPN O
- PUNCT O
Gs PROPN O
α PROPN O
, PUNCT O
FAK PROPN O
/ SYM O
Scr PROPN O
, PUNCT O
and CCONJ O
STAT3 PROPN O
signaling NOUN O
pathways NOUN O
[ PUNCT O
5 NUM O
] PUNCT O
. PUNCT O

Cobalt NOUN B-LF
( PUNCT I-LF
III NUM I-LF
) PUNCT I-LF
protoporphyrin NOUN I-LF
- PUNCT I-LF
IX NOUN I-LF
- PUNCT I-LF
chloride NOUN I-LF
( PUNCT O
CoPP PROPN B-AC
) PUNCT O
or CCONJ O
tin NOUN O
protoporphyrin NOUN O
- PUNCT O
IX NOUN O
( PUNCT O
SnPP)-treated PROPN B-AC
BM PROPN B-AC
- PUNCT B-AC
DCs NOUN B-AC
from ADP O
BALB PROPN O
/ X O
c NOUN O
mice NOUN O
were AUX O
stimulated VERB O
with ADP O
or CCONJ O
without ADP O
LPS PROPN O
( PUNCT O
1 NUM O
μg NOUN O
/ X O
ml NOUN O
) PUNCT O
for ADP O
24 NUM O
hours NOUN O
. PUNCT O

SD NOUN B-AC
: PUNCT O
standard ADJ B-LF
deviation NOUN I-LF

ASO PROPN B-AC
01–15 NUM O
targets VERB O
the DET O
exonic ADJ O
portion NOUN O
of ADP O
the DET O
3′ NUM O
splice NOUN O
site NOUN O
, PUNCT O
whereas SCONJ O
ASOs NOUN B-AC
11–25 NUM O
, PUNCT O
16–30 NUM O
, PUNCT O
21–35 NUM O
, PUNCT O
and CCONJ O
26–40 NUM O
target VERB O
a DET O
central ADJ O
region NOUN O
that PRON O
comprises VERB O
a DET O
transformer NOUN B-LF
2 NUM I-LF
beta NOUN I-LF
1 NUM I-LF
protein NOUN I-LF
( PUNCT O
Tra2β1)-binding NOUN B-AC
motif NOUN O
in ADP O
SMN PROPN B-AC
exon NOUN O
7 NUM O
[ PUNCT O
38 NUM O
] PUNCT O
. PUNCT O

The DET O
adjusted VERB B-LF
hazard NOUN I-LF
ratios NOUN I-LF
( PUNCT O
aHRs NOUN B-AC
) PUNCT O
and CCONJ O
95 NUM O
% NOUN O
confidence NOUN B-LF
intervals NOUN I-LF
( PUNCT O
CIs NOUN B-AC
) PUNCT O
and CCONJ O
98 NUM O
% NOUN O
CIs NOUN B-AC
of ADP O
incident NOUN O
fragility NOUN O
fracture NOUN O
and CCONJ O
osteoporosis NOUN O
/ SYM O
fragility NOUN O
fracture NOUN O
were AUX O
estimated VERB O
using VERB O
the DET O
multivariable ADJ O
Cox PROPN O
proportional ADJ O
hazard NOUN O
model NOUN O
after ADP O
adjusting VERB O
for ADP O
age NOUN O
, PUNCT O
sex NOUN O
, PUNCT O
occupation NOUN O
, PUNCT O
drug NOUN O
use NOUN O
, PUNCT O
and CCONJ O
comorbidities NOUN O
. PUNCT O

Note VERB O
that SCONJ O
TPGmax NOUN O
and CCONJ O
TPGmean NOUN O
are AUX O
estimated VERB O
based VERB O
on ADP O
the DET O
equation NOUN O
for ADP O
the DET O
transvalvular ADJ B-LF
pressure NOUN I-LF
gradient NOUN I-LF
( PUNCT O
TPG NOUN B-AC
= SYM O
4 NUM O
× SYM O
velcoity2 NOUN O
) PUNCT O
. PUNCT O

Previous ADJ O
studies NOUN O
have AUX O
emphasized VERB O
that SCONJ O
drivers NOUN O
of ADP O
high ADJ O
- PUNCT O
order NOUN O
thalamic ADJ O
nuclei NOUN O
, PUNCT O
such ADJ O
as ADP O
the DET O
MD PROPN B-AC
or CCONJ O
the DET O
ventral ADJ B-LF
anterior ADJ I-LF
nucleus NOUN I-LF
( PUNCT O
VA PROPN B-AC
) PUNCT O
, PUNCT O
originate VERB O
from ADP O
large ADJ O
layer NOUN O
5 NUM O
cortical ADJ O
neurons NOUN O
( PUNCT O
e.g. X O
, PUNCT O
[ X O
22,24,36 NUM O
] PUNCT O
; PUNCT O
reviewed VERB O
in ADP O
[ X O
37,38 NUM O
] PUNCT O
) PUNCT O
. PUNCT O

Front ADJ B-LF
- PUNCT I-LF
of ADP I-LF
- PUNCT I-LF
pack NOUN I-LF
( PUNCT O
FOP PROPN B-AC
) PUNCT O
nutrition NOUN O
labels NOUN O
have AUX O
received VERB O
growing VERB O
attention NOUN O
from ADP O
policy NOUN O
makers NOUN O
worldwide ADV O
, PUNCT O
as SCONJ O
they PRON O
are AUX O
considered VERB O
promising ADJ O
tools NOUN O
in ADP O
public ADJ O
health NOUN O
nutrition NOUN O
[ PUNCT O
1,2 NUM O
] PUNCT O
. PUNCT O

The DET O
lethality NOUN O
can AUX O
be AUX O
rescued VERB O
by ADP O
concurrent ADJ O
knockout NOUN O
of ADP O
interferon NOUN B-LF
induced VERB I-LF
with ADP I-LF
helicase PROPN I-LF
C PROPN I-LF
domain NOUN I-LF
1 NUM I-LF
( PUNCT O
IFIH1 PROPN B-AC
, PUNCT O
also ADV O
called VERB O
MDA5 PROPN O
) PUNCT O
, PUNCT O
a DET O
cytosolic ADJ O
sensor NOUN O
that PRON O
recognizes VERB O
viral ADJ O
dsRNA NOUN B-AC
and CCONJ O
induces VERB O
the DET O
type NOUN O
I NUM O
IFN PROPN B-AC
- PUNCT O
mediated VERB O
antiviral ADJ O
immunity NOUN O
[ X O
25,26 NUM O
] PUNCT O
. PUNCT O

HD NOUN B-AC
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
Pf PROPN B-AC
infection NOUN O
; PUNCT O
LD PROPN B-AC
, PUNCT O
low ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
Pf PROPN B-AC
infection NOUN O
; PUNCT O
RR NOUN B-AC
, PUNCT O
risk NOUN B-LF
ratio NOUN I-LF
; PUNCT O
RRadj PROPN O
, PUNCT O
adjusted VERB O
RR NOUN B-AC
. PUNCT O
sd NOUN O
- PUNCT O
mRDT NOUN B-AC
, PUNCT O
standard ADJ O
malaria NOUN O
RDT NOUN O
; PUNCT O
us PROPN O
- PUNCT O
qPCR PROPN B-AC
, PUNCT O
quantitative ADJ O
PCR NOUN O
. PUNCT O

ART PROPN B-AC
, PUNCT O
antiretroviral ADJ B-LF
therapy NOUN I-LF
; PUNCT O
HIV PROPN O
- PUNCT O
ve PROPN O
, PUNCT O
HIV PROPN O
negative ADJ O
; PUNCT O
SOC PROPN B-AC
, PUNCT O
standard NOUN B-LF
of ADP I-LF
care NOUN I-LF
; PUNCT O
ST PROPN O
, PUNCT O
self NOUN O
- PUNCT O
test NOUN O
; PUNCT O
VMMC PROPN B-AC
, PUNCT O
voluntary ADJ B-LF
medical ADJ I-LF
male ADJ I-LF
circumcision NOUN I-LF
. PUNCT O

Anti ADJ O
- PUNCT O
miR-17 NOUN B-AC
- PUNCT B-AC
5p NOUN B-AC
also ADV O
lowered VERB O
luciferase NOUN O
activities NOUN O
of ADP O
constructs NOUN O
harboring VERB O
four NUM O
out ADP O
of ADP O
six NUM O
PTEN PROPN B-AC
3’UTR NOUN O
binding VERB O
sites NOUN O
predicted VERB O
for ADP O
miR-17 NOUN B-AC
- PUNCT B-AC
3p NOUN B-AC
( PUNCT O
Fig NOUN O
13B NUM O
) PUNCT O
. PUNCT O
These DET O
results NOUN O
implied VERB O
that SCONJ O
artificial ADJ O
anti ADJ O
- PUNCT O
miR-17 NOUN B-AC
- PUNCT B-AC
5p NOUN B-AC
DNA NOUN O
- PUNCT O
LNA NOUN B-AC
against ADP O
miR-17 NOUN B-AC
- PUNCT B-AC
5p NOUN B-AC
guide NOUN O
strand NOUN O
could AUX O
exert VERB O
functions NOUN O
of ADP O
an DET O
miRNA NOUN B-AC
by ADP O
mimicking VERB O
the DET O
passenger NOUN B-LF
strand NOUN I-LF
of ADP I-LF
miR-17 NOUN I-LF
- PUNCT B-AC
5p NOUN B-AC
, PUNCT O
and CCONJ O
could AUX O
interact VERB O
with ADP O
some PRON O
of ADP O
the DET O
miR-17 NOUN B-AC
- PUNCT B-AC
3p NOUN B-AC
binding VERB O
sites NOUN O
in ADP O
the DET O
3’UTR NOUN O
of ADP O
PDCD4 PROPN B-AC
and CCONJ O
PTEN PROPN B-AC
mRNAs NOUN O
. PUNCT O

We PRON O
found VERB O
that SCONJ O
the DET O
pharmacological ADJ O
inhibition NOUN O
of ADP O
p65 NOUN O
NF PROPN B-AC
- NOUN B-AC
κB NOUN B-AC
activation NOUN O
via ADP O
the DET O
specific ADJ O
inhibitor NOUN O
caffeic ADJ B-LF
acid NOUN I-LF
phenethyl NOUN I-LF
ester NOUN I-LF
( PUNCT O
CAPE PROPN B-AC
) PUNCT O
did AUX O
not PART O
affect VERB O
the DET O
increased VERB O
activity NOUN O
of ADP O
p38 NOUN O
MAPK NOUN B-AC
or CCONJ O
PKCζ NOUN B-AC
caused VERB O
by ADP O
CCL20 PROPN B-AC
overexpression NOUN O
( PUNCT O
Fig NOUN O
5B NUM O
, PUNCT O
S5A NOUN O
Fig NOUN O
) PUNCT O
, PUNCT O
which PRON O
suggested VERB O
that SCONJ O
p65 NOUN O
probably ADV O
was AUX O
the DET O
downstream ADJ O
effector NOUN O
of ADP O
p38 NOUN O
MAPK NOUN B-AC
or CCONJ O
PKCζ NOUN B-AC
when SCONJ O
transducing VERB O
CCL20 PROPN B-AC
stimuli NOUN O
. PUNCT O

CHA2DS2 PROPN B-AC
- PUNCT B-AC
VASc PROPN B-AC
, PUNCT O
Congestive ADJ B-LF
heart NOUN I-LF
failure NOUN I-LF
, PUNCT I-LF
Hypertension NOUN I-LF
, PUNCT I-LF
Age NOUN I-LF
≥ SYM I-LF
75 NUM I-LF
years NOUN I-LF
, PUNCT I-LF
Diabetes NOUN I-LF
, PUNCT I-LF
previous ADJ I-LF
Stroke NOUN I-LF
, PUNCT I-LF
Vascular ADJ I-LF
disease NOUN I-LF
, PUNCT I-LF
Age NOUN I-LF
65–74 NUM I-LF
years NOUN I-LF
, PUNCT I-LF
Sex NOUN I-LF
category NOUN I-LF
. PUNCT O

PCell PROPN B-AC
, PUNCT O
pyramidal ADJ B-LF
cell NOUN I-LF
. PUNCT O

VPP PROPN B-AC
: PUNCT O
valine NOUN B-LF
– SYM I-LF
proline NOUN I-LF
– SYM I-LF
proline NOUN I-LF
. PUNCT O

Therefore ADV O
, PUNCT O
it PRON O
is AUX O
crucial ADJ O
to PART O
determine VERB O
the DET O
post ADJ B-LF
- ADJ I-LF
mortem ADJ I-LF
interval NOUN I-LF
( PUNCT O
PMI NOUN B-AC
) PUNCT O
as ADP O
precisely ADV O
as ADP O
possible ADJ O
. PUNCT O

Concomitantly ADV O
, PUNCT O
the DET O
Talin PROPN O
concentration NOUN O
at ADP O
attachment NOUN O
sites NOUN O
increases VERB O
5 ADV O
- ADV O
fold ADV O
as SCONJ O
quantified VERB O
by ADP O
fluorescence NOUN B-LF
correlation NOUN I-LF
spectroscopy NOUN I-LF
( PUNCT O
FCS PROPN B-AC
) PUNCT O
, PUNCT O
suggesting VERB O
that SCONJ O
only ADV O
a DET O
small ADJ O
proportion NOUN O
of ADP O
Talin PROPN O
molecules NOUN O
are AUX O
mechanically ADV O
engaged VERB O
at ADP O
any DET O
given VERB O
time NOUN O
. PUNCT O

The DET O
control NOUN O
of ADP O
PMk PROPN B-AC
was AUX O
represented VERB O
as ADP O
the DET O
root NOUN B-LF
- PUNCT I-LF
mean NOUN I-LF
- PUNCT I-LF
square NOUN I-LF
( PUNCT O
RMS PROPN B-AC
) PUNCT O
of ADP O
the DET O
PAk PROPN B-AC
time NOUN O
- PUNCT O
series NOUN O
with ADP O
respect NOUN O
to ADP O
trial NOUN O
duration NOUN O
( PUNCT O
t NOUN O
) PUNCT O
( PUNCT O
PAkRMS PROPN O
) PUNCT O
( PUNCT O
Eq NOUN O
1 NUM O
) PUNCT O
. PUNCT O

Non PROPN B-LF
- PUNCT I-LF
Invasive PROPN I-LF
Ventilation PROPN I-LF
( PUNCT O
NIV PROPN B-AC
) PUNCT O
reduces VERB O
in ADP O
- PUNCT O
hospital NOUN O
mortality NOUN O
in ADP O
selected VERB O
patients NOUN O
with ADP O
acute ADJ B-LF
respiratory ADJ I-LF
failure NOUN I-LF
( PUNCT O
ARF PROPN B-AC
) PUNCT O
[ X O
1–4 NUM O
] PUNCT O
. PUNCT O

Then ADV O
, PUNCT O
these DET O
binomial ADJ O
pulses NOUN O
were AUX O
tested VERB O
in ADP O
combination NOUN O
with ADP O
the DET O
“ PUNCT O
Sum PROPN B-LF
- PUNCT I-LF
Of ADP I-LF
- PUNCT I-LF
Square PROPN I-LF
” PUNCT O
( PUNCT O
SOS PROPN B-AC
) PUNCT O
technique NOUN O
, PUNCT O
in ADP O
order NOUN O
to PART O
suppress VERB O
banding NOUN O
artifacts NOUN O
. PUNCT O

We PRON O
found VERB O
that SCONJ O
the DET O
presence NOUN O
of ADP O
ctDNA NOUN B-AC
at ADP O
baseline NOUN O
was AUX O
an DET O
independent ADJ O
marker NOUN O
of ADP O
poor ADJ O
prognosis NOUN O
, PUNCT O
with ADP O
a DET O
median ADJ O
overall ADJ O
survival NOUN O
of ADP O
13.6 NUM O
versus ADP O
21.5 NUM O
mo NOUN O
( PUNCT O
adjusted VERB O
hazard NOUN B-LF
ratio NOUN I-LF
[ X O
HR NOUN B-AC
] X O
1.82 NUM O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN O
1.01–3.55 NUM O
, PUNCT O
p NOUN O
= SYM O
0.045 NUM O
) PUNCT O
and CCONJ O
a DET O
median ADJ O
progression NOUN O
- PUNCT O
free ADJ O
survival NOUN O
of ADP O
4.9 NUM O
versus ADP O
10.4 NUM O
mo NOUN O
( PUNCT O
adjusted VERB O
HR NOUN B-AC
2.14 NUM O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN O
1.30–3.67 NUM O
, PUNCT O
p NOUN O
= SYM O
0.002 NUM O
) PUNCT O
. PUNCT O

In ADP O
2005 NUM O
, PUNCT O
the DET O
Yellow PROPN O
Fever PROPN O
Initiative PROPN O
— PUNCT O
a DET O
collaboration NOUN O
between ADP O
the DET O
World PROPN O
Health PROPN O
Organization PROPN O
( PUNCT O
WHO PROPN O
) PUNCT O
and CCONJ O
the DET O
United PROPN O
Nations PROPN O
Children PROPN O
Fund PROPN O
supported VERB O
by ADP O
the DET O
Global PROPN B-LF
Alliance PROPN I-LF
for ADP I-LF
Vaccines PROPN I-LF
and CCONJ I-LF
Immunization PROPN I-LF
( PUNCT O
GAVI PROPN B-AC
Alliance)—was PROPN O
launched VERB O
to PART O
create VERB O
a DET O
vaccine NOUN O
stockpile NOUN O
for ADP O
use NOUN O
in ADP O
epidemics NOUN O
and CCONJ O
to PART O
implement VERB O
preventive ADJ O
mass NOUN O
vaccination NOUN O
campaigns NOUN O
in ADP O
the DET O
12 NUM O
most ADV O
affected VERB O
countries NOUN O
in ADP O
West PROPN O
Africa PROPN O
. PUNCT O

The DET O
ventilation NOUN B-LF
rate NOUN I-LF
( PUNCT O
VR NOUN B-AC
) PUNCT O
could AUX O
be AUX O
set VERB O
by ADP O
altering VERB O
the DET O
motor NOUN O
voltage NOUN O
. PUNCT O

A DET O
Cochrane PROPN O
systematic ADJ O
review NOUN O
suggests VERB O
that SCONJ O
multi ADJ O
- ADJ O
faceted ADJ O
interventions NOUN O
are AUX O
the DET O
best ADJ O
way NOUN O
to PART O
reduce VERB O
inappropriate ADJ O
prescriptions NOUN O
[ X O
8 NUM O
] PUNCT O
in ADP O
combining VERB O
educational ADJ O
interventions NOUN O
for ADP O
General PROPN B-LF
Practitioners PROPN I-LF
( PUNCT O
GPs PROPN B-AC
) PUNCT O
and CCONJ O
practical ADJ O
tools NOUN O
easily ADV O
usable ADJ O
in ADP O
primary ADJ O
care NOUN O
[ X O
9,10 NUM O
] PUNCT O
. PUNCT O

Among ADP O
patients NOUN O
with ADP O
stage NOUN O
II NUM O
esophageal ADJ O
cancer NOUN O
, PUNCT O
definitive ADJ O
CCRT PROPN B-AC
was AUX O
associated VERB O
with ADP O
a DET O
significantly ADV O
higher ADJ O
recurrence NOUN O
rate NOUN O
relative ADJ O
to ADP O
surgery NOUN O
with ADP O
combined VERB O
therapy NOUN O
( PUNCT O
odd ADJ O
ratios NOUN O
[ PUNCT O
OR NOUN B-AC
] PUNCT O
: PUNCT O
1.46 NUM O
, PUNCT O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
[ PUNCT O
CI NOUN B-AC
] PUNCT O
: PUNCT O
1.07–1.98 NUM O
, PUNCT O
p NOUN O
= SYM O
0.018 NUM O
) PUNCT O
, PUNCT O
although SCONJ O
no DET O
significant ADJ O
difference NOUN O
was AUX O
observed VERB O
among ADP O
patients NOUN O
with ADP O
stage NOUN O
III NUM O
disease NOUN O
( PUNCT O
OR NOUN B-AC
: PUNCT O
1.21 NUM O
, PUNCT O
95 NUM O
% NOUN O
CI NOUN B-AC
: PUNCT O
0.90–1.64 NUM O
, PUNCT O
p NOUN O
= SYM O
0.214 NUM O
) PUNCT O
( PUNCT O
Table PROPN O
4 NUM O
) PUNCT O
. PUNCT O

PVI PROPN B-AC
was AUX O
performed VERB O
in ADP O
all DET O
studies NOUN O
and CCONJ O
an DET O
additional ADJ O
linear ADJ O
or CCONJ O
complex ADJ B-LF
fractionated ADJ I-LF
atrial ADJ I-LF
electrogram NOUN I-LF
( PUNCT O
CFAE PROPN B-AC
) PUNCT O
ablation NOUN O
was AUX O
performed VERB O
in ADP O
4 NUM O
studies NOUN O
. PUNCT O

However ADV O
, PUNCT O
the DET O
expressions NOUN O
of ADP O
epithelial ADJ B-LF
- NOUN I-LF
mesenchymal ADJ I-LF
transition NOUN I-LF
( PUNCT O
EMT PROPN B-AC
) PUNCT O
marker NOUN O
genes NOUN O
, PUNCT O
such ADJ O
as ADP O
N NOUN O
- NOUN O
cadherin NOUN O
and CCONJ O
E NOUN O
- NOUN O
cadherin NOUN O
, PUNCT O
were AUX O
not PART O
changed VERB O
in ADP O
the DET O
kidneys NOUN O
after ADP O
UUO PROPN B-AC
. PUNCT O
Masson PROPN O
’s PART O
trichrome NOUN O
staining NOUN O
and CCONJ O
fluorescence NOUN O
immunostaining NOUN O
showed VERB O
that SCONJ O
piceatannol NOUN O
administration NOUN O
attenuated VERB O
collagen NOUN O
deposition NOUN O
in ADP O
UUO PROPN B-AC
kidneys NOUN O
. PUNCT O

The DET O
human ADJ O
upper ADJ B-LF
respiratory ADJ I-LF
tract NOUN I-LF
( PUNCT O
URT PROPN B-AC
) PUNCT O
is AUX O
repeatedly ADV O
exposed VERB O
to ADP O
a DET O
large ADJ O
variety NOUN O
of ADP O
inhaled VERB O
microbes NOUN O
; PUNCT O
accordingly ADV O
, PUNCT O
upper ADJ B-LF
respiratory ADJ I-LF
tract NOUN I-LF
infections NOUN I-LF
( PUNCT O
URTI PROPN B-AC
) PUNCT O
constitute VERB O
the DET O
most ADV O
common ADJ O
reason NOUN O
for ADP O
emergency NOUN O
room NOUN O
visits NOUN O
in ADP O
primary ADJ O
health NOUN O
care NOUN O
[ PUNCT O
1 NUM O
, PUNCT O
2 NUM O
] PUNCT O
. PUNCT O

Please INTJ O
add VERB O
the DET O
following ADJ O
statement NOUN O
, PUNCT O
or CCONJ O
similar ADJ O
, PUNCT O
to ADP O
the DET O
Methods NOUN O
: PUNCT O
" PUNCT O
This DET O
study NOUN O
is AUX O
reported VERB O
as ADP O
per ADP O
the DET O
Strengthening VERB B-LF
the DET I-LF
Reporting PROPN I-LF
of ADP I-LF
Observational PROPN I-LF
Studies PROPN I-LF
in ADP I-LF
Epidemiology PROPN I-LF
( PUNCT O
STROBE PROPN B-AC
) PUNCT O
guideline NOUN O
( PUNCT O
S1 PROPN O
Checklist PROPN O
) PUNCT O
. PUNCT O
" PUNCT O
The DET O
STROBE PROPN B-AC
guideline NOUN O
can AUX O
be AUX O
found VERB O
here ADV O
: PUNCT O
http://www.equator-network.org/reporting-guidelines/strobe/ X O

Higher ADJ O
levels NOUN O
of ADP O
glucose NOUN B-LF
infusion NOUN I-LF
rate NOUN I-LF
( PUNCT O
GIR PROPN B-AC
) PUNCT O
were AUX O
found VERB O
in ADP O
the DET O
UA PROPN B-AC
- PUNCT O
treated VERB O
mice NOUN O
than ADP O
controls NOUN O
during ADP O
the DET O
clamp NOUN O
( PUNCT O
Fig PROPN O
1 NUM O
M NUM O
) PUNCT O
. PUNCT O
This DET O
increase NOUN O
in ADP O
GIR PROPN B-AC
was AUX O
caused VERB O
by ADP O
elevated ADJ O
whole ADJ O
- PUNCT O
body NOUN O
glucose NOUN O
uptake NOUN O
as ADP O
well ADV O
as ADP O
the DET O
decreased VERB O
endogenous ADJ O
hepatic ADJ O
glucose NOUN O
production NOUN O
during ADP O
the DET O
clamp NOUN O
( PUNCT O
Fig PROPN O
1N NUM O
and CCONJ O
1O NUM O
) PUNCT O
. PUNCT O
Consistently ADV O
, PUNCT O
UA PROPN B-AC
- PUNCT O
treated VERB O
mice NOUN O
showed VERB O
higher ADJ O
levels NOUN O
of ADP O
insulin NOUN O
- PUNCT O
stimulated VERB O
glucose NOUN O
uptake NOUN O
in ADP O
gastrocnemius NOUN O
muscle NOUN O
, PUNCT O
BAT PROPN B-AC
, PUNCT O
and CCONJ O
WAT PROPN B-AC
than ADP O
controls NOUN O
during ADP O
the DET O
clamp NOUN O
( PUNCT O
Fig PROPN O
1P NUM O
) PUNCT O
. PUNCT O
Note VERB O
that SCONJ O
similar ADJ O
levels NOUN O
of ADP O
glucose NOUN O
were AUX O
observed VERB O
between ADP O
control NOUN O
and CCONJ O
UA PROPN B-AC
- PUNCT O
treated VERB O
mice NOUN O
under ADP O
normal ADJ O
diet NOUN O
feeding NOUN O
( PUNCT O
S1E PROPN O
Fig PROPN O
) PUNCT O
, PUNCT O
consistent ADJ O
with ADP O
their PRON O
comparable ADJ O
body NOUN O
weight NOUN O
. PUNCT O

Participants NOUN O
were AUX O
from ADP O
the DET O
‘ PUNCT O
Change NOUN B-LF
in ADP I-LF
alcohol NOUN I-LF
outlet NOUN I-LF
density NOUN I-LF
and CCONJ I-LF
alcohol NOUN I-LF
- PUNCT I-LF
related VERB I-LF
harm NOUN I-LF
to ADP I-LF
population NOUN I-LF
health NOUN I-LF
’ PUNCT O
( PUNCT O
CHALICE PROPN B-AC
) PUNCT O
study NOUN O
[ PUNCT O
10 NUM O
] PUNCT O
. PUNCT O

The DET O
mice NOUN O
were AUX O
killed VERB O
in ADP O
humane ADJ O
fashion NOUN O
via ADP O
CO2 NOUN O
asphyxiation NOUN O
and CCONJ O
cervical ADJ O
dislocation NOUN O
according VERB O
to ADP O
the DET O
American PROPN B-LF
Veterinary PROPN I-LF
Medical PROPN I-LF
Association PROPN I-LF
( PUNCT O
AVMA PROPN B-AC
) PUNCT O
Guidelines PROPN O
. PUNCT O

Somatic ADJ O
embryogenesis NOUN O
( PUNCT O
number NOUN O
/ SYM O
g NOUN O
FW NOUN B-AC
): PUNCT O
Number NOUN O
of ADP O
somatic ADJ O
embryogenesis NOUN O
/ SYM O
fresh ADJ B-LF
weight NOUN I-LF
of ADP O
initial ADJ O
inoculation NOUN O
during ADP O
pre NOUN O
- NOUN O
culture NOUN O

DALY PROPN B-AC
, PUNCT O
disability NOUN B-LF
- PUNCT I-LF
adjusted VERB I-LF
life NOUN I-LF
year NOUN I-LF
; PUNCT O
NMB PROPN O
, PUNCT O
net ADJ O
monetary ADJ O
benefit NOUN O
; PUNCT O
PMC PROPN B-AC
, PUNCT O
polyvalent ADJ B-LF
meningococcal NOUN I-LF
conjugate NOUN I-LF
; PUNCT O
PMP PROPN B-AC
, PUNCT O
polyvalent ADJ B-LF
meningococcal NOUN I-LF
polysaccharide NOUN I-LF
. PUNCT O