new

Get trending papers in your email inbox!

Subscribe

Daily Papers

byAK and the research community

Oct 6

DADM: Dual Alignment of Domain and Modality for Face Anti-spoofing

With the availability of diverse sensor modalities (i.e., RGB, Depth, Infrared) and the success of multi-modal learning, multi-modal face anti-spoofing (FAS) has emerged as a prominent research focus. The intuition behind it is that leveraging multiple modalities can uncover more intrinsic spoofing traces. However, this approach presents more risk of misalignment. We identify two main types of misalignment: (1) Intra-domain modality misalignment, where the importance of each modality varies across different attacks. For instance, certain modalities (e.g., Depth) may be non-defensive against specific attacks (e.g., 3D mask), indicating that each modality has unique strengths and weaknesses in countering particular attacks. Consequently, simple fusion strategies may fall short. (2) Inter-domain modality misalignment, where the introduction of additional modalities exacerbates domain shifts, potentially overshadowing the benefits of complementary fusion. To tackle (1), we propose a alignment module between modalities based on mutual information, which adaptively enhances favorable modalities while suppressing unfavorable ones. To address (2), we employ a dual alignment optimization method that aligns both sub-domain hyperplanes and modality angle margins, thereby mitigating domain gaps. Our method, dubbed Dual Alignment of Domain and Modality (DADM), achieves state-of-the-art performance in extensive experiments across four challenging protocols demonstrating its robustness in multi-modal domain generalization scenarios. The codes will be released soon.

DADAO: Decoupled Accelerated Decentralized Asynchronous Optimization

This work introduces DADAO: the first decentralized, accelerated, asynchronous, primal, first-order algorithm to minimize a sum of L-smooth and mu-strongly convex functions distributed over a given network of size n. Our key insight is based on modeling the local gradient updates and gossip communication procedures with separate independent Poisson Point Processes. This allows us to decouple the computation and communication steps, which can be run in parallel, while making the whole approach completely asynchronous, leading to communication acceleration compared to synchronous approaches. Our new method employs primal gradients and does not use a multi-consensus inner loop nor other ad-hoc mechanisms such as Error Feedback, Gradient Tracking, or a Proximal operator. By relating the inverse of the smallest positive eigenvalue of the Laplacian matrix chi_1 and the maximal resistance chi_2leq chi_1 of the graph to a sufficient minimal communication rate between the nodes of the network, we show that our algorithm requires O(nfrac{L{mu}}log(1{epsilon})) local gradients and only O(nchi_1chi_2frac{L{mu}}log(1{epsilon})) communications to reach a precision epsilon, up to logarithmic terms. Thus, we simultaneously obtain an accelerated rate for both computations and communications, leading to an improvement over state-of-the-art works, our simulations further validating the strength of our relatively unconstrained method. We also propose a SDP relaxation to find the optimal gossip rate of each edge minimizing the total number of communications for a given graph, resulting in faster convergence compared to standard approaches relying on uniform communication weights. Our source code is released on a public repository.

Causality and Renormalization in Finite-Time-Path Out-of-Equilibrium $φ^3$ QFT

Our aim is to contribute to quantum field theory (QFT) formalisms useful for descriptions of short time phenomena, dominant especially in heavy ion collisions. We formulate out-of-equilibrium QFT within the finite-time-path formalism (FTP) and renormalization theory (RT). The potential conflict of FTP and RT is investigated in g phi^3 QFT, by using the retarded/advanced (R/A) basis of Green functions and dimensional renormalization (DR). For example, vertices immediately after (in time) divergent self-energy loops do not conserve energy, as integrals diverge. We "repair" them, while keeping d<4, to obtain energy conservation at those vertices. Already in the S-matrix theory, the renormalized, finite part of Feynman self-energy Sigma_{F}(p_0) does not vanish when |p_0|rightarrowinfty and cannot be split to retarded and advanced parts. In the Glaser--Epstein approach, the causality is repaired in the composite object G_F(p_0)Sigma_{F}(p_0). In the FTP approach, after repairing the vertices, the corresponding composite objects are G_R(p_0)Sigma_{R}(p_0) and Sigma_{A}(p_0)G_A(p_0). In the limit drightarrow 4, one obtains causal QFT. The tadpole contribution splits into diverging and finite parts. The diverging, constant component is eliminated by the renormalization condition langle 0|phi|0rangle =0 of the S-matrix theory. The finite, oscillating energy-nonconserving tadpole contributions vanish in the limit trightarrow infty .

A Modular Approach for Clinical SLMs Driven by Synthetic Data with Pre-Instruction Tuning, Model Merging, and Clinical-Tasks Alignment

High computation costs and latency of large language models such as GPT-4 have limited their deployment in clinical settings. Small language models (SLMs) offer a cost-effective alternative, but their limited capacity requires biomedical domain adaptation, which remains challenging. An additional bottleneck is the unavailability and high sensitivity of clinical data. To address these challenges, we propose a novel framework for adapting SLMs into high-performing clinical models. We introduce the MediPhi collection of 3.8B-parameter SLMs developed with our novel framework: pre-instruction tuning of experts on relevant medical and clinical corpora (PMC, Medical Guideline, MedWiki, etc.), model merging, and clinical-tasks alignment. To cover most clinical tasks, we extended the CLUE benchmark to CLUE+, doubling its size. Our expert models deliver relative improvements on this benchmark over the base model without any task-specific fine-tuning: 64.3% on medical entities, 49.5% on radiology reports, and 44% on ICD-10 coding (outperforming GPT-4-0125 by 14%). We unify the expert models into MediPhi via model merging, preserving gains across benchmarks. Furthermore, we built the MediFlow collection, a synthetic dataset of 2.5 million high-quality instructions on 14 medical NLP tasks, 98 fine-grained document types, and JSON format support. Alignment of MediPhi using supervised fine-tuning and direct preference optimization achieves further gains of 18.9% on average.

Aligning Language Models Using Follow-up Likelihood as Reward Signal

In natural human-to-human conversations, participants often receive feedback signals from one another based on their follow-up reactions. These reactions can include verbal responses, facial expressions, changes in emotional state, and other non-verbal cues. Similarly, in human-machine interactions, the machine can leverage the user's follow-up utterances as feedback signals to assess whether it has appropriately addressed the user's request. Therefore, we propose using the likelihood of follow-up utterances as rewards to differentiate preferred responses from less favored ones, without relying on human or commercial LLM-based preference annotations. Our proposed reward mechanism, ``Follow-up Likelihood as Reward" (FLR), matches the performance of strong reward models trained on large-scale human or GPT-4 annotated data on 8 pairwise-preference and 4 rating-based benchmarks. Building upon the FLR mechanism, we propose to automatically mine preference data from the online generations of a base policy model. The preference data are subsequently used to boost the helpfulness of the base model through direct alignment from preference (DAP) methods, such as direct preference optimization (DPO). Lastly, we demonstrate that fine-tuning the language model that provides follow-up likelihood with natural language feedback significantly enhances FLR's performance on reward modeling benchmarks and effectiveness in aligning the base policy model's helpfulness.

Weak-to-Strong 3D Object Detection with X-Ray Distillation

This paper addresses the critical challenges of sparsity and occlusion in LiDAR-based 3D object detection. Current methods often rely on supplementary modules or specific architectural designs, potentially limiting their applicability to new and evolving architectures. To our knowledge, we are the first to propose a versatile technique that seamlessly integrates into any existing framework for 3D Object Detection, marking the first instance of Weak-to-Strong generalization in 3D computer vision. We introduce a novel framework, X-Ray Distillation with Object-Complete Frames, suitable for both supervised and semi-supervised settings, that leverages the temporal aspect of point cloud sequences. This method extracts crucial information from both previous and subsequent LiDAR frames, creating Object-Complete frames that represent objects from multiple viewpoints, thus addressing occlusion and sparsity. Given the limitation of not being able to generate Object-Complete frames during online inference, we utilize Knowledge Distillation within a Teacher-Student framework. This technique encourages the strong Student model to emulate the behavior of the weaker Teacher, which processes simple and informative Object-Complete frames, effectively offering a comprehensive view of objects as if seen through X-ray vision. Our proposed methods surpass state-of-the-art in semi-supervised learning by 1-1.5 mAP and enhance the performance of five established supervised models by 1-2 mAP on standard autonomous driving datasets, even with default hyperparameters. Code for Object-Complete frames is available here: https://github.com/sakharok13/X-Ray-Teacher-Patching-Tools.

CapSpeech: Enabling Downstream Applications in Style-Captioned Text-to-Speech

Recent advancements in generative artificial intelligence have significantly transformed the field of style-captioned text-to-speech synthesis (CapTTS). However, adapting CapTTS to real-world applications remains challenging due to the lack of standardized, comprehensive datasets and limited research on downstream tasks built upon CapTTS. To address these gaps, we introduce CapSpeech, a new benchmark designed for a series of CapTTS-related tasks, including style-captioned text-to-speech synthesis with sound events (CapTTS-SE), accent-captioned TTS (AccCapTTS), emotion-captioned TTS (EmoCapTTS), and text-to-speech synthesis for chat agent (AgentTTS). CapSpeech comprises over 10 million machine-annotated audio-caption pairs and nearly 0.36 million human-annotated audio-caption pairs. In addition, we introduce two new datasets collected and recorded by a professional voice actor and experienced audio engineers, specifically for the AgentTTS and CapTTS-SE tasks. Alongside the datasets, we conduct comprehensive experiments using both autoregressive and non-autoregressive models on CapSpeech. Our results demonstrate high-fidelity and highly intelligible speech synthesis across a diverse range of speaking styles. To the best of our knowledge, CapSpeech is the largest available dataset offering comprehensive annotations for CapTTS-related tasks. The experiments and findings further provide valuable insights into the challenges of developing CapTTS systems.

Realism in Action: Anomaly-Aware Diagnosis of Brain Tumors from Medical Images Using YOLOv8 and DeiT

In the field of medical sciences, reliable detection and classification of brain tumors from images remains a formidable challenge due to the rarity of tumors within the population of patients. Therefore, the ability to detect tumors in anomaly scenarios is paramount for ensuring timely interventions and improved patient outcomes. This study addresses the issue by leveraging deep learning (DL) techniques to detect and classify brain tumors in challenging situations. The curated data set from the National Brain Mapping Lab (NBML) comprises 81 patients, including 30 Tumor cases and 51 Normal cases. The detection and classification pipelines are separated into two consecutive tasks. The detection phase involved comprehensive data analysis and pre-processing to modify the number of image samples and the number of patients of each class to anomaly distribution (9 Normal per 1 Tumor) to comply with real world scenarios. Next, in addition to common evaluation metrics for the testing, we employed a novel performance evaluation method called Patient to Patient (PTP), focusing on the realistic evaluation of the model. In the detection phase, we fine-tuned a YOLOv8n detection model to detect the tumor region. Subsequent testing and evaluation yielded competitive performance both in Common Evaluation Metrics and PTP metrics. Furthermore, using the Data Efficient Image Transformer (DeiT) module, we distilled a Vision Transformer (ViT) model from a fine-tuned ResNet152 as a teacher in the classification phase. This approach demonstrates promising strides in reliable tumor detection and classification, offering potential advancements in tumor diagnosis for real-world medical imaging scenarios.

Biomedical Large Languages Models Seem not to be Superior to Generalist Models on Unseen Medical Data

Large language models (LLMs) have shown potential in biomedical applications, leading to efforts to fine-tune them on domain-specific data. However, the effectiveness of this approach remains unclear. This study evaluates the performance of biomedically fine-tuned LLMs against their general-purpose counterparts on a variety of clinical tasks. We evaluated their performance on clinical case challenges from the New England Journal of Medicine (NEJM) and the Journal of the American Medical Association (JAMA) and on several clinical tasks (e.g., information extraction, document summarization, and clinical coding). Using benchmarks specifically chosen to be likely outside the fine-tuning datasets of biomedical models, we found that biomedical LLMs mostly perform inferior to their general-purpose counterparts, especially on tasks not focused on medical knowledge. While larger models showed similar performance on case tasks (e.g., OpenBioLLM-70B: 66.4% vs. Llama-3-70B-Instruct: 65% on JAMA cases), smaller biomedical models showed more pronounced underperformance (e.g., OpenBioLLM-8B: 30% vs. Llama-3-8B-Instruct: 64.3% on NEJM cases). Similar trends were observed across the CLUE (Clinical Language Understanding Evaluation) benchmark tasks, with general-purpose models often performing better on text generation, question answering, and coding tasks. Our results suggest that fine-tuning LLMs to biomedical data may not provide the expected benefits and may potentially lead to reduced performance, challenging prevailing assumptions about domain-specific adaptation of LLMs and highlighting the need for more rigorous evaluation frameworks in healthcare AI. Alternative approaches, such as retrieval-augmented generation, may be more effective in enhancing the biomedical capabilities of LLMs without compromising their general knowledge.

Your Agent May Misevolve: Emergent Risks in Self-evolving LLM Agents

Advances in Large Language Models (LLMs) have enabled a new class of self-evolving agents that autonomously improve through interaction with the environment, demonstrating strong capabilities. However, self-evolution also introduces novel risks overlooked by current safety research. In this work, we study the case where an agent's self-evolution deviates in unintended ways, leading to undesirable or even harmful outcomes. We refer to this as Misevolution. To provide a systematic investigation, we evaluate misevolution along four key evolutionary pathways: model, memory, tool, and workflow. Our empirical findings reveal that misevolution is a widespread risk, affecting agents built even on top-tier LLMs (e.g., Gemini-2.5-Pro). Different emergent risks are observed in the self-evolutionary process, such as the degradation of safety alignment after memory accumulation, or the unintended introduction of vulnerabilities in tool creation and reuse. To our knowledge, this is the first study to systematically conceptualize misevolution and provide empirical evidence of its occurrence, highlighting an urgent need for new safety paradigms for self-evolving agents. Finally, we discuss potential mitigation strategies to inspire further research on building safer and more trustworthy self-evolving agents. Our code and data are available at https://github.com/ShaoShuai0605/Misevolution . Warning: this paper includes examples that may be offensive or harmful in nature.

BrowseComp-ZH: Benchmarking Web Browsing Ability of Large Language Models in Chinese

As large language models (LLMs) evolve into tool-using agents, the ability to browse the web in real-time has become a critical yardstick for measuring their reasoning and retrieval competence. Existing benchmarks such as BrowseComp concentrate on English and overlook the linguistic, infrastructural, and censorship-related complexities of other major information ecosystems -- most notably Chinese. To address this gap, we introduce BrowseComp-ZH, a high-difficulty benchmark purpose-built to comprehensively evaluate LLM agents on the Chinese web. BrowseComp-ZH consists of 289 multi-hop questions spanning 11 diverse domains. Each question is reverse-engineered from a short, objective, and easily verifiable answer (e.g., a date, number, or proper noun). A two-stage quality control protocol is applied to strive for high question difficulty and answer uniqueness. We benchmark over 20 state-of-the-art language models and agentic search systems on our proposed BrowseComp-ZH. Despite their strong conversational and retrieval capabilities, most models struggle severely: a large number achieve accuracy rates below 10%, and only a handful exceed 20%. Even the best-performing system, OpenAI's DeepResearch, reaches just 42.9%. These results demonstrate the considerable difficulty of BrowseComp-ZH, where success demands not only effective retrieval strategies, but also sophisticated reasoning and information reconciliation -- capabilities that current models still struggle to master. Our dataset, construction guidelines, and benchmark results have been publicly released at https://github.com/PALIN2018/BrowseComp-ZH.

Benchmarking Large Language Models on CMExam -- A Comprehensive Chinese Medical Exam Dataset

Recent advancements in large language models (LLMs) have transformed the field of question answering (QA). However, evaluating LLMs in the medical field is challenging due to the lack of standardized and comprehensive datasets. To address this gap, we introduce CMExam, sourced from the Chinese National Medical Licensing Examination. CMExam consists of 60K+ multiple-choice questions for standardized and objective evaluations, as well as solution explanations for model reasoning evaluation in an open-ended manner. For in-depth analyses of LLMs, we invited medical professionals to label five additional question-wise annotations, including disease groups, clinical departments, medical disciplines, areas of competency, and question difficulty levels. Alongside the dataset, we further conducted thorough experiments with representative LLMs and QA algorithms on CMExam. The results show that GPT-4 had the best accuracy of 61.6% and a weighted F1 score of 0.617. These results highlight a great disparity when compared to human accuracy, which stood at 71.6%. For explanation tasks, while LLMs could generate relevant reasoning and demonstrate improved performance after finetuning, they fall short of a desired standard, indicating ample room for improvement. To the best of our knowledge, CMExam is the first Chinese medical exam dataset to provide comprehensive medical annotations. The experiments and findings of LLM evaluation also provide valuable insights into the challenges and potential solutions in developing Chinese medical QA systems and LLM evaluation pipelines. The dataset and relevant code are available at https://github.com/williamliujl/CMExam.

SimpleSpeech 2: Towards Simple and Efficient Text-to-Speech with Flow-based Scalar Latent Transformer Diffusion Models

Scaling Text-to-speech (TTS) to large-scale datasets has been demonstrated as an effective method for improving the diversity and naturalness of synthesized speech. At the high level, previous large-scale TTS models can be categorized into either Auto-regressive (AR) based (e.g., VALL-E) or Non-auto-regressive (NAR) based models (e.g., NaturalSpeech 2/3). Although these works demonstrate good performance, they still have potential weaknesses. For instance, AR-based models are plagued by unstable generation quality and slow generation speed; meanwhile, some NAR-based models need phoneme-level duration alignment information, thereby increasing the complexity of data pre-processing, model design, and loss design. In this work, we build upon our previous publication by implementing a simple and efficient non-autoregressive (NAR) TTS framework, termed SimpleSpeech 2. SimpleSpeech 2 effectively combines the strengths of both autoregressive (AR) and non-autoregressive (NAR) methods, offering the following key advantages: (1) simplified data preparation; (2) straightforward model and loss design; and (3) stable, high-quality generation performance with fast inference speed. Compared to our previous publication, we present ({\romannumeral1}) a detailed analysis of the influence of speech tokenizer and noisy label for TTS performance; ({\romannumeral2}) four distinct types of sentence duration predictors; ({\romannumeral3}) a novel flow-based scalar latent transformer diffusion model. With these improvement, we show a significant improvement in generation performance and generation speed compared to our previous work and other state-of-the-art (SOTA) large-scale TTS models. Furthermore, we show that SimpleSpeech 2 can be seamlessly extended to multilingual TTS by training it on multilingual speech datasets. Demos are available on: {https://dongchaoyang.top/SimpleSpeech2\_demo/}.

FinTruthQA: A Benchmark Dataset for Evaluating the Quality of Financial Information Disclosure

Accurate and transparent financial information disclosure is essential in accounting and finance, fostering trust and enabling informed investment decisions that drive economic development. Among many information disclosure platforms, the Chinese stock exchanges' investor interactive platform provides a novel and interactive way for listed firms to disclose information of interest to investors through an online question-and-answer (Q&A) format. However, it is common for listed firms to respond to questions with limited or no substantive information, and automatically evaluating the quality of financial information disclosure on large amounts of Q&A pairs is challenging. In this study, our interdisciplinary team of AI and finance professionals proposed FinTruthQA, a benchmark designed to evaluate advanced natural language processing (NLP) techniques for the automatic quality assessment of information disclosure in financial Q&A data. It comprises 6,000 real-world financial Q&A entries and each Q&A was manually annotated based on four key evaluation criteria. We benchmarked various NLP techniques on FinTruthQA, including large language models(LLMs). Experiments showed that existing NLP models have strong predictive ability for question identification and question relevance tasks, but are suboptimal for answer readability and answer relevance tasks. By establishing this benchmark, we provide a robust foundation for the automatic evaluation of information disclosure, demonstrating how AI can be leveraged for social good by promoting transparency, fairness, and investor protection in financial disclosure practices. FinTruthQA can be used by auditors, regulators, and financial analysts for real-time monitoring and data-driven decision-making, as well as by researchers for advanced studies in accounting and finance, ultimately fostering greater trust and efficiency in the financial markets.

PRIMER: JWST/MIRI reveals the evolution of star-forming structures in galaxies at z<2.5

The stellar structures of star-forming galaxies (SFGs) undergo significant size growth during their mass assembly and must pass through a compaction phase as they evolve into quiescent galaxies (QGs). To shed light on the mechanisms behind this structural evolution, we study the morphology of the star-forming components of 665 SFGs at 0<z<2.5 measured using JWST/MIRI observation and compare them with the morphology of their stellar components taken from the literature. The stellar and star-forming components of most SFGs (66%) have extended disk-like structures that are aligned with each other and are of the same size. The star-forming components of these galaxies follow a mass-size relation, similar to that followed by their stellar components. At the highest mass, the optical S\'ersic index of these SFGs increases to 2.5, suggesting the presence of a dominant stellar bulge. Because their star-forming components remain disk-like, these bulges cannot have formed by secular in-situ growth. We identify a second population of galaxies lying below the MIR mass-size relation, with compact star-forming components embedded in extended stellar components (EC galaxy). These galaxies are overall rare (15%) but become more dominant (30%) at high mass (>10^{10.5}M_odot). The compact star-forming components of these galaxies are also concentrated and slightly spheroidal, suggesting that this compaction phase can build dense bulge in-situ. Finally, we identify a third population of SFGs (19%), with both compact stellar and star-forming components. The density of their stellar cores resemble those of QGs and are compatible with being the descendants of EC galaxy. Overall, the structural evolution of SFGs is mainly dominated by a secular inside-out growth, which can, however, be interrupted by violent compaction phase(s) that can build dominant stellar bulges like those in massive SFGs or QGs.

Vision-Language Models Meet Meteorology: Developing Models for Extreme Weather Events Detection with Heatmaps

Real-time detection and prediction of extreme weather protect human lives and infrastructure. Traditional methods rely on numerical threshold setting and manual interpretation of weather heatmaps with Geographic Information Systems (GIS), which can be slow and error-prone. Our research redefines Extreme Weather Events Detection (EWED) by framing it as a Visual Question Answering (VQA) problem, thereby introducing a more precise and automated solution. Leveraging Vision-Language Models (VLM) to simultaneously process visual and textual data, we offer an effective aid to enhance the analysis process of weather heatmaps. Our initial assessment of general-purpose VLMs (e.g., GPT-4-Vision) on EWED revealed poor performance, characterized by low accuracy and frequent hallucinations due to inadequate color differentiation and insufficient meteorological knowledge. To address these challenges, we introduce ClimateIQA, the first meteorological VQA dataset, which includes 8,760 wind gust heatmaps and 254,040 question-answer pairs covering four question types, both generated from the latest climate reanalysis data. We also propose Sparse Position and Outline Tracking (SPOT), an innovative technique that leverages OpenCV and K-Means clustering to capture and depict color contours in heatmaps, providing ClimateIQA with more accurate color spatial location information. Finally, we present Climate-Zoo, the first meteorological VLM collection, which adapts VLMs to meteorological applications using the ClimateIQA dataset. Experiment results demonstrate that models from Climate-Zoo substantially outperform state-of-the-art general VLMs, achieving an accuracy increase from 0% to over 90% in EWED verification. The datasets and models in this study are publicly available for future climate science research: https://github.com/AlexJJJChen/Climate-Zoo.

StarCoder 2 and The Stack v2: The Next Generation

The BigCode project, an open-scientific collaboration focused on the responsible development of Large Language Models for Code (Code LLMs), introduces StarCoder2. In partnership with Software Heritage (SWH), we build The Stack v2 on top of the digital commons of their source code archive. Alongside the SWH repositories spanning 619 programming languages, we carefully select other high-quality data sources, such as GitHub pull requests, Kaggle notebooks, and code documentation. This results in a training set that is 4x larger than the first StarCoder dataset. We train StarCoder2 models with 3B, 7B, and 15B parameters on 3.3 to 4.3 trillion tokens and thoroughly evaluate them on a comprehensive set of Code LLM benchmarks. We find that our small model, StarCoder2-3B, outperforms other Code LLMs of similar size on most benchmarks, and also outperforms StarCoderBase-15B. Our large model, StarCoder2- 15B, significantly outperforms other models of comparable size. In addition, it matches or outperforms CodeLlama-34B, a model more than twice its size. Although DeepSeekCoder- 33B is the best-performing model at code completion for high-resource languages, we find that StarCoder2-15B outperforms it on math and code reasoning benchmarks, as well as several low-resource languages. We make the model weights available under an OpenRAIL license and ensure full transparency regarding the training data by releasing the SoftWare Heritage persistent IDentifiers (SWHIDs) of the source code data.

The X-ray Integral Field Unit at the end of the Athena reformulation phase

The Athena mission entered a redefinition phase in July 2022, driven by the imperative to reduce the mission cost at completion for the European Space Agency below an acceptable target, while maintaining the flagship nature of its science return. This notably called for a complete redesign of the X-ray Integral Field Unit (X-IFU) cryogenic architecture towards a simpler active cooling chain. Passive cooling via successive radiative panels at spacecraft level is now used to provide a 50 K thermal environment to an X-IFU owned cryostat. 4.5 K cooling is achieved via a single remote active cryocooler unit, while a multi-stage Adiabatic Demagnetization Refrigerator ensures heat lift down to the 50 mK required by the detectors. Amidst these changes, the core concept of the readout chain remains robust, employing Transition Edge Sensor microcalorimeters and a SQUID-based Time-Division Multiplexing scheme. Noteworthy is the introduction of a slower pixel. This enables an increase in the multiplexing factor (from 34 to 48) without compromising the instrument energy resolution, hence keeping significant system margins to the new 4 eV resolution requirement. This allows reducing the number of channels by more than a factor two, and thus the resource demands on the system, while keeping a 4' field of view (compared to 5' before). In this article, we will give an overview of this new architecture, before detailing its anticipated performances. Finally, we will present the new X-IFU schedule, with its short term focus on demonstration activities towards a mission adoption in early 2027.

MedGemma Technical Report

Artificial intelligence (AI) has significant potential in healthcare applications, but its training and deployment faces challenges due to healthcare's diverse data, complex tasks, and the need to preserve privacy. Foundation models that perform well on medical tasks and require less task-specific tuning data are critical to accelerate the development of healthcare AI applications. We introduce MedGemma, a collection of medical vision-language foundation models based on Gemma 3 4B and 27B. MedGemma demonstrates advanced medical understanding and reasoning on images and text, significantly exceeding the performance of similar-sized generative models and approaching the performance of task-specific models, while maintaining the general capabilities of the Gemma 3 base models. For out-of-distribution tasks, MedGemma achieves 2.6-10% improvement on medical multimodal question answering, 15.5-18.1% improvement on chest X-ray finding classification, and 10.8% improvement on agentic evaluations compared to the base models. Fine-tuning MedGemma further improves performance in subdomains, reducing errors in electronic health record information retrieval by 50% and reaching comparable performance to existing specialized state-of-the-art methods for pneumothorax classification and histopathology patch classification. We additionally introduce MedSigLIP, a medically-tuned vision encoder derived from SigLIP. MedSigLIP powers the visual understanding capabilities of MedGemma and as an encoder achieves comparable or better performance than specialized medical image encoders. Taken together, the MedGemma collection provides a strong foundation of medical image and text capabilities, with potential to significantly accelerate medical research and development of downstream applications. The MedGemma collection, including tutorials and model weights, can be found at https://goo.gle/medgemma.

MedShapeNet -- A Large-Scale Dataset of 3D Medical Shapes for Computer Vision

Prior to the deep learning era, shape was commonly used to describe the objects. Nowadays, state-of-the-art (SOTA) algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from numerous shape-related publications in premier vision conferences as well as the growing popularity of ShapeNet (about 51,300 models) and Princeton ModelNet (127,915 models). For the medical domain, we present a large collection of anatomical shapes (e.g., bones, organs, vessels) and 3D models of surgical instrument, called MedShapeNet, created to facilitate the translation of data-driven vision algorithms to medical applications and to adapt SOTA vision algorithms to medical problems. As a unique feature, we directly model the majority of shapes on the imaging data of real patients. As of today, MedShapeNet includes 23 dataset with more than 100,000 shapes that are paired with annotations (ground truth). Our data is freely accessible via a web interface and a Python application programming interface (API) and can be used for discriminative, reconstructive, and variational benchmarks as well as various applications in virtual, augmented, or mixed reality, and 3D printing. Exemplary, we present use cases in the fields of classification of brain tumors, facial and skull reconstructions, multi-class anatomy completion, education, and 3D printing. In future, we will extend the data and improve the interfaces. The project pages are: https://medshapenet.ikim.nrw/ and https://github.com/Jianningli/medshapenet-feedback