:Resource:Target
https://rdf.guidetopharmacology.org/GRAC/target3072
Plasmodium falciparum histone deacetylase 1
Plasmodium falciparum histone deacetylase 1
:Resource:SyntheticOrganicLigand
https://rdf.guidetopharmacology.org/GRAC/ligand7504
nexturastat A
JZWXMCPARMXZQV-UHFFFAOYSA-N
InChI=1S/C19H23N3O3/c1-2-3-13-22(19(24)20-17-7-5-4-6-8-17)14-15-9-11-16(12-10-15)18(23)21-25/h4-12,25H,2-3,13-14H2,1H3,(H,20,24)(H,21,23)
CCCCN(C(=O)Nc1ccccc1)Cc1ccc(cc1)C(=O)NO
CCCCN(C(=O)Nc1ccccc1)Cc1ccc(cc1)C(=O)NO
Nexturastat A is a potent and selective HDAC6 inhibitor
<Reference id=24597/>.
4-{[butyl(phenylcarbamoyl)amino]methyl}-N-hydroxybenzamide
S7473
f
nexturastat A
:Resource:SyntheticOrganicLigand
https://rdf.guidetopharmacology.org/GRAC/ligand7502
resminostat
FECGNJPYVFEKOD-VMPITWQZSA-N
InChI=1S/C16H19N3O4S/c1-18(2)11-13-3-6-15(7-4-13)24(22,23)19-10-9-14(12-19)5-8-16(20)17-21/h3-10,12,21H,11H2,1-2H3,(H,17,20)/b8-5+
ONC(=O)C=Cc1ccn(c1)S(=O)(=O)c1ccc(cc1)CN(C)C
ONC(=O)/C=C/c1ccn(c1)S(=O)(=O)c1ccc(cc1)CN(C)C
Resminostat is an HDAC inhibitor with selectivity for HDACs 1, 3 and
6, with significantly lower affinity for HDAC8 <Reference id=24592/>.
(E)-3-[1-[4-(dimethylaminomethyl)phenyl]sulfonylpyrrol-3-yl]-N-hydroxyprop-2-enamide
BYK408740
f
resminostat
:Resource:SyntheticOrganicLigand
https://rdf.guidetopharmacology.org/GRAC/ligand7500
RGFP966
BLVQHYHDYFTPDV-VCABWLAWSA-N
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O=C(Nc1ccc(cc1N)F)C=Cc1cnn(c1)CC=Cc1ccccc1
O=C(Nc1ccc(cc1N)F)/C=C/c1cnn(c1)C/C=C/c1ccccc1
RGFP966 is a selective inhibitor of histone deacetylase 3 (HDAC3)
<Reference id=24589/>. In rodent studies, RGFP966-induced inhibition of HDAC3
appears to enhance memory processes involved in extinction of drug-seeking behaviour
<Reference id=24589/>.
(2E)-N-(2-amino-4-fluorophenyl)-3-{1-[(2E)-3-phenylprop-2-en-1-yl]-1H-pyrazol-4-yl}prop-2-enamide
RGFP-966
f
RGFP966
:Resource:SyntheticOrganicLigand
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belinostat
NCNRHFGMJRPRSK-MDZDMXLPSA-N
InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
ONC(=O)C=Cc1cccc(c1)S(=O)(=O)Nc1ccccc1
ONC(=O)/C=C/c1cccc(c1)S(=O)(=O)Nc1ccccc1
Belinostat is a pan-histone deacetylase (HDAC) inhibitor
<Reference id=24578/><Reference id=23750/>.
(E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide
Beleodaq®
t
belinostat
:Resource:SyntheticOrganicLigand
https://rdf.guidetopharmacology.org/GRAC/ligand7489
panobinostat
FPOHNWQLNRZRFC-ZHACJKMWSA-N
InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
ONC(=O)C=Cc1ccc(cc1)CNCCc1c(C)[nH]c2c1cccc2
ONC(=O)/C=C/c1ccc(cc1)CNCCc1c(C)[nH]c2c1cccc2
Panobinostat is a non-selective histone deacetylase (HDAC) inhibitor
<Reference id=24577/><Reference id=24578/>. The compound also has
antimalarial activity. <br><br>The <b>Malaria</b> tab on
this ligand page provides additional curator comments of relevance to the Guide to
MALARIA PHARMACOLOGY.
(E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide
LBH589
t
panobinostat
:Resource:SyntheticOrganicLigand
https://rdf.guidetopharmacology.org/GRAC/ligand7010
ricolinostat
QGZYDVAGYRLSKP-UHFFFAOYSA-N
InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)
ONC(=O)CCCCCCNC(=O)c1cnc(nc1)N(c1ccccc1)c1ccccc1
ONC(=O)CCCCCCNC(=O)c1cnc(nc1)N(c1ccccc1)c1ccccc1
Rocilinostat is an investigational HDAC6 inhibitor <Reference
id=24127/>. But note that it exhibits only ~10-fold enzymic selectivity against
the class I isoform, HDAC1.
N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide
ACY-1215
f
ricolinostat
:Resource:SyntheticOrganicLigand
https://rdf.guidetopharmacology.org/GRAC/ligand7007
entinostat
INVTYAOGFAGBOE-UHFFFAOYSA-N
InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
O=C(OCc1cccnc1)NCc1ccc(cc1)C(=O)Nc1ccccc1N
O=C(OCc1cccnc1)NCc1ccc(cc1)C(=O)Nc1ccccc1N
Entinostat (MS-275) inhibits Class I histone deacetylases (HDACs 1,
2, 3 & 8), but has been shown to be somewhat selective for HDAC1 <Reference
id=23898/><Reference id=23750/>. Studies in rodent models of inflammation
suggest that inhibition by entinostat may be clinically useful <Reference
id=23899/><Reference id=23900/><Reference id=23901/><Reference
id=23902/>, perhaps more so than broader acting Class I HDAC inhibitors such as
vorinostat (SAHA) <Reference id=23902/>.
pyridin-3-ylmethyl
N-({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)carbamate
SNDX-275
f
entinostat
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3.5.1.- Histone deacetylases (HDACs)
3.5.1.- Histone deacetylases (HDACs)
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Chromatin modifying enzymes (<i>Plasmodium</i> spp.)
Chromatin modifying enzymes (<i>Plasmodium</i>
spp.)
:Resource
http://identifiers.org/pubmed/20139990
:Resource
http://identifiers.org/pubmed/22262760
:Resource
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:Resource
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:Resource
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:Resource
http://identifiers.org/pubmed/32815366
:Resource
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:Resource
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:Resource
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:Resource:Target
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histone deacetylase 8
histone deacetylase 8
:Resource:Target
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histone deacetylase 3
histone deacetylase 3
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histone deacetylase 2
histone deacetylase 2
:Resource:Target
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histone deacetylase 9
histone deacetylase 9
:Resource:Target
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histone deacetylase 6
histone deacetylase 6
:Resource:Target
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histone deacetylase 1
histone deacetylase 1
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histone deacetylase 4
histone deacetylase 4
:Resource
http://identifiers.org/pubmed/26199860
:Resource:Target
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histone deacetylase 7
histone deacetylase 7
:Resource:Target
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histone deacetylase 5
histone deacetylase 5
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