milestone4.csv

Patent Number,Abstract,Claims
13144833,"Regimen for the treatment of rosacea include the application of an anti-redness composition to at least a portion of the cleansed area of skin afflicted with rosacea. The regimen may include the application of one or more of a polymetal complex, a composition containing metronidazole, and/or a protective composition. Kits containing components useful in performing such regimens are also described.","1. A treatment regimen comprising: cleansing at least a portion of an area of skin afflicted with rosacea with an antimicrobial or cleanser; applying an anti-redness composition to at least a portion of the cleansed area; and applying a protective composition to at least a portion of the cleansed, and moisturized area. 2. A treatment regimen as in claim 1 further comprising the step of applying a composition containing metronidazole to at least a portion of the afflicted area. 3. A treatment regimen as in claim 1 wherein the protective composition comprises a sunscreen. 4. A treatment regimen as in claim 1 wherein the protective composition comprises a compound selected from the group consisting of ZnO, Vitamin A, Vitamin D and combinations thereof. 5. A treatment regimen as in claim 1 further comprising applying a benzoyl peroxide containing composition to at least a portion of the cleansed, and moisturized area of skin. 6. A treatment regimen as in claim 1 further comprising applying a retinoid containing composition to at least a portion of the cleansed, moisturized area of skin. 7. A treatment regimen as in claim 1 further comprising applying an antibiotic containing composition to at least a portion of the cleansed, and moisturized area of skin. 8. The treatment method of claim 1 further comprising taking an oral antibiotic after applying the protective composition. 9. A kit comprising: a outer package enclosing individual containers containing a cleanser; an anti-redness composition; and a protective composition. 10. A treatment regimen comprising: cleansing at least a portion of an area of skin afflicted with rosacea with an antimicrobial or cleanser; applying a composition containing a polymetal complex to at least a portion of the cleansed area; and applying a protective composition to at least a portion of the cleansed and polymetal complex-treated area. 11. The treatment regimen as in claim 10, further comprising applying a composition containing metronidazole to at least a portion of the afflicted area. 12. The treatment regimen as in claim 10 further comprising applying to at least a portion of the afflicted area an additional ingredient selected from the group consisting of an anti-redness composition, an anti-parasitic compound, and combinations thereof. 13. The treatment regimen of claim 12, wherein the anti parasitic product is selected from the group consisting of benzyl benzoate, salicylic acid and combinations thereof. 14. The treatment regimen as in claim 10, wherein the polymetal complex comprises a Cu/Zn malonate complex. 15. The treatment regimen as in claim 10, wherein the protective composition comprises a sunscreen. 16. The treatment regimen as in claim 10, wherein the protective composition comprises a compound selected from the group consisting of ZnO, Vitamin A, Vitamin D and combinations thereof. 17. The treatment regimen as in claim 10, further comprising applying a benzoyl peroxide containing composition to at least a portion of the cleansed, and moisturized area of skin. 18. The treatment regimen as in claim 10, further comprising applying a retinoid containing composition to at least a portion of the cleansed, moisturized area of skin. 19. The treatment regimen as in claim 10, further comprising applying an antibiotic containing composition to at least a portion of the cleansed, and moisturized area of skin. 20. The treatment method of claim 10, further comprising taking an oral antibiotic after applying the protective composition. 21. A kit comprising: a cleanser; a composition containing a polymetal complex; and a protective composition. 22. The kit as in claim 21, further comprising a composition containing an additional ingredient selected from the group consisting of metronidazole, an anti-redness composition, an antibiotic, an anti-parasitic composition and combinations thereof. 23. The kit as in claim 21, wherein the composition containing a polymetal complex is a moisturizing composition. 24. The kit as in claim 21, wherein the protective composition is a sunscreen containing vitamins A and D. 25. A method of treating skin afflicted with rosacea comprising the step of applying a redness reducing amount of a composition containing a polymetal complex to at least a portion of the afflicted area. 26. The method of claim 25, wherein the polymetal complex is a Cu/Zn malonate complex. 27. The method of claim 25, wherein the composition containing a polymetal complex further includes a moisturizer. 28. The method of claim 25, further comprising the step of cleansing at least a portion of the afflicted area. 29. The method of claim 25, wherein the cleanser is an antimicrobial cleanser. 30. The method of claim 29 wherein the antimicrobial cleanser is selected from the group consisting of chlorhexidine gluconate, triclosan, zinc pyrithione, clindamycin phosphate, sodium sulphacetamide and combinations thereof. 31. The method of claim 25 further comprising applying a protective composition to at least a portion of the afflicted area. 32. The method of claim 31 wherein the protective composition comprises a sunscreen. 33. The method of claim 31 wherein the sunscreen comprises a compound selected from the group consisting of ZnO, Vitamin A, Vitamin D and combinations thereof. 34. The method of claim of claim 25 further comprising applying an anti-parasitic product to at least a portion of the afflicted area. 35. The method of claim 34 wherein the anti-parasitic product includes a compound selected from the group consisting of benzyl benzoate, salicyclic acid and combinations thereof. 36. The method of claim 25 further comprising applying an additional an anti-acne medication to at least a portion of the afflicted area. 37. The method of claim 36 wherein the anti-acne medication is selected from the group consisting of benzoyl peroxide, retinoids, tetracycline, clindamycin, erythromycin, and combinations thereof. 38. A method of treating skin afflicted with rosacea comprising sequentially applying a cleanser, an anti-redness composition, and a protective composition to at least a portion of the afflicted area. 39. The method of claim of claim 38 further comprising applying a composition containing metronidazole to at least a portion of the afflicted area. 40. The method of claim 38 further comprising applying an anti-acne medication to at least a portion of the afflicted area. 41. The method of claim 40 wherein the anti-acne, medication is selected from the group consisting of benzoyl peroxide, retinoids, tetracycline, clindamycin, erythromycin, and combinations thereof."
14006524,"A clamp arrangement includes a pair of brackets adapted to be clamped on opposing sides of the wooden post to encapsulate a fractured portion, each bracket is made from an integral sheet of metal cut and pressed to define a longitudinal hemispherical chamber and a pair of longitudinal flanges extended out from each, the longitudinal hemispherical chamber having an upper end wherein a lip is supported in the lateral extension by a multitude of pressed out ribs such that when the clamp arrangement is required to be driven into the ground about the wooden post, the lip provides a support location for an impact tool to drive the clamp arrangement into the ground.","1. A clamp arrangement for supporting a fractured portion of a wooden post wherein at least part of the clamp arrangement needs to be driven into the ground about the wooden post, said arrangement including: a pair of brackets adapted to be clamped on opposing sides of the wooden post to encapsulate said fractured portion; each bracket made from an integral sheet of metal cut and pressed to define a longitudinal hemispherical chamber of compatible diameter dimensions to the wooden post; a pair of longitudinal flanges extended out from each side at a circumferential circumference edge at an open end of the longitudinal hemispherical chamber, wherein each flange includes a plurality of holes so that when each bracket is brought together about the post the plurality of holes on the respective longitudinal flanges line up so that a fastening arrangement can pass through the holes to clamp each bracket together about the post; said longitudinal hemispherical chamber having an upper end, said upper end characterised in having a laterally extended lip, wherein the lip is supported in the lateral extension by a multitude of pressed out ribs emanating from an internal side at said upper end of the longitudinal hemispherical chamber such that when the clamp arrangement is required to be driven into the ground about the wooden post, the lip provides a support location for an impact tool to drive the clamp arrangement into the ground. 2. (canceled) 3. The clamp arrangement of claim 1 wherein the pressed out ribs on the internal side at the upper end of the longitudinal hemispherical chamber provide a series of levelled out peaks and intermittent troughs where the levelled out peaks are configured to abut up against the external surface of the post. 4. The clamp arrangement of claim 2 wherein the intermittent troughs between the levelled out peaks of the pressed out ribs provide a passage for air flow down through the bracket when fastened to the post. 5. The clamp arrangement of claim 1 wherein the longitudinal hemispherical chamber includes a configuration of pressed out interconnected diamond shaped protrusions that emboss out over the external surface of the longitudinal hemispherical chamber. 6. The clamp arrangement of claim 4, wherein the configuration of pressed out interconnected diamond shaped protrusions that emboss out over the external surface of the longitudinal hemispherical chamber have joined edges that are pressed out along the edge where the longitudinal flanges extend out from each side of the circumferential edge at the open end of the longitudinal hemispherical chamber. 7. The clamp arrangement of claim 4 wherein a multiplicity of pressed tabs are embossed out along a contact fold where the longitudinal flanges extend out from each side of the circumferential edge at the open end of the longitudinal hemispherical chamber. 8. The clamp arrangement of claim 1 wherein the holes along each of the longitudinal flanges include a raised rim or collar. 9. The clamp arrangement of claim 1 wherein the longitudinal hemispherical chamber includes additional holes on its surface wherein nails and so forth can be passed there through to provide additional fixation of the bracket to the wooden post. 10. The clamp arrangement of claim 1 wherein the impact tool is a hammer and/or a motor driveable ramming device including a jack hammer. 11. The clamp arrangement of claim 1 wherein an outside edge of each longitudinal flange includes a rounded shoulder. 12. The clamp arrangement of claim 1 wherein the bracket further includes an aperture to which wire and/or trellis connected to adjacent posts can be wrapped around or supported there from. 13. The clamp arrangement of claim 1 wherein the longitudinal flange extending out from each side of the circumferential edge at the open edge of the longitudinal hemispherical chamber at the ground engaging end is tapered. 14. The clamp arrangement of claim 1 wherein the integral sheet of metal is a single sheet of thickness between 1 mm to 3.2 mm"
14365653,"A system and method for device action and configuration based on user context detection from sensors in peripheral devices are disclosed. A particular embodiment includes: a peripheral device including one or more sensors to produce sensor data; and logic, at least a portion of which is partially implemented in hardware, the logic configured to determine a context from the sensor data and to perform at least one action based on the determined context, the at least one action including modifying a configuration in a mobile device for sending notifications to a user.","1-20. (canceled) 21. A mobile device comprising: logic, at least a portion of which is partially implemented in hardware, the logic configured to determine a context from sensor data and to perform at least one action based on the determined context, the at least one action including modifying a configuration in a mobile device for sending notifications to a user. 22. The mobile device as claimed in claim 21 wherein the sensor data being encoded with audio signals and received on a microphone line via a microphone conductor of an audio jack. 23. The mobile device as claimed in claim 21 including a sensor data receiver to receive sensor data produced by one or more sensors in a peripheral device and to provide the received sensor data to the logic for processing. 24. The mobile device as claimed in claim 23 wherein the sensor data receiver includes a wireless transceiver, the sensor data being received via a wireless data transmission. 25. The mobile device as claimed in claim 21 wherein the sensor data is of a type from the group consisting of: biometric data, heart rate data, temperature data, pressure data, acceleration data, galvanic skin response data, and global positioning system data. 26. The mobile device as claimed in claim 21 wherein the mobile device is a mobile phone. 27. A system comprising: a peripheral device including one or more sensors to produce sensor data; and logic, at least a portion of which is partially implemented in hardware, the logic configured to determine a context from the sensor data and to perform at least one action based on the determined context, the at least one action including modifying a configuration in a mobile device for sending notifications to a user. 28. The system as claimed in claim 27 wherein the sensor data being encoded with audio signals and received on a microphone line via a microphone conductor of an audio jack. 29. The system as claimed in claim 28 wherein the peripheral device including a microcontroller coupled to the one or more sensors to receive the sensor data generated by the one or more sensors, the microcontroller being further configured to encode the sensor data into an audio band signal, the peripheral device including an adder to combine the encoded data with audio signals on the microphone line, the adder being further configured to transfer the combined audio signals via the microphone conductor of the audio jack. 30. The system as claimed in claim 27 including a sensor data receiver to receive the sensor data produced by the one or more sensors in the peripheral device and to provide the received sensor data to the logic for processing. 31. The system as claimed in claim 30 wherein the peripheral device includes a wireless transceiver, the sensor data being sent via a wireless data transmission. 32. The system as claimed in claim 27 wherein the sensor data produced by the one or more sensors in the peripheral device is biometric data. 33. The system as claimed in claim 27 wherein the sensor data is of a type from the group consisting of: heart rate data, temperature data, pressure data, acceleration data, galvanic skin response data, and global positioning system data. 34. The system as claimed in claim 27 wherein the logic is implemented in a mobile phone. 35. The system as claimed in claim 27 wherein the peripheral device is from the group consisting of: a headset and an earbud accessory. 36. A non-transitory machine-useable storage medium embodying instructions which, when executed by a machine, cause the machine to: receive sensor data produced by one or more sensors in a peripheral device; transfer the sensor data to a mobile device for processing; determine a context from the sensor data; and perform at least one action based on the determined context, the at least one action including modifying a configuration in the mobile device for sending notifications to a user. 37. The machine-useable storage medium as claimed in claim 36 wherein the instructions being further configured to receive the sensor data on a microphone line via a microphone conductor of an audio jack. 38. The machine-useable storage medium as claimed in claim 36 wherein the instructions being further configured to receive the sensor data via a wireless data transmission. 39. The machine-useable storage medium as claimed in claim 36 wherein the sensor data produced by the one or more sensors in the peripheral device is biometric data. 40. The machine-useable storage medium as claimed in claim 36 wherein the sensor data is of a type from the group consisting of: heart rate data, temperature data, pressure data, acceleration data, galvanic skin response data, and global positioning system data."
14396367,"Systems and methods for managing datasets produced by alert-triggering search queries in data aggregation and analysis systems. An example method may comprise: executing, by one or more processing devices, a search query on a portion of searchable data associated with a time window to produce a dataset comprising one or more results; responsive to determining that at least a portion of the dataset satisfies a triggering condition defining an alert associated with the search query, generating an instance of the alert; associating, by a memory data structure, the instance of the alert with an identifier of the search query and a time parameter specifying the time window; receiving, from a client computing device, a request for the portion of the dataset; and responsive to determining that the portion of the dataset is not stored in the memory in a manner associating it with the instance of the alert, reproducing the portion of the dataset by re-executing the search query in view of the time parameter.","1. A method, comprising: executing, by one or more processing devices, a search query on a portion of searchable data associated with a time window to produce a dataset comprising one or more results; responsive to determining that at least a portion of the dataset satisfies a triggering condition defining an alert associated with the search query, generating an instance of the alert; associating, by a memory data structure, the instance of the alert with an identifier of the search query and a time parameter specifying the time window; receiving, from a client computing device, a request for the portion of the dataset; and responsive to determining that the portion of the dataset is not stored in the memory in a manner associating it with the instance of the alert, reproducing the portion of the dataset by re-executing the search query in view of the time parameter. 2. The method of claim 1, further comprising: storing, in a memory associated with the computer system, the portion of the dataset and an association of the stored portion of the dataset with the instance of the alert. 3. The method of claim 1, further comprising: implementing a file retention policy with respect to datasets stored in the memory, wherein the file retention policy requires deleting certain datasets responsive to evaluating corresponding file retention conditions. 4. The method of claim 1, further comprising: transmitting the copy of the portion of the dataset to the client computing device. 5. The method of claim 1, further comprising associating the instance of the alert with an identifier of the triggering condition. 6. The method of claim 1, wherein the searchable data includes time-stamped events having portions of raw machine data. 7. The method of claim 1, further comprising: transmitting, to the client computing device, a notification of the instance of the alert. 8. The method of claim 1, wherein the client computing device includes at least one of: a desktop computing device or a mobile computing device. 9. The method of claim 1, wherein executing the search query on the portion of searchable data includes applying a late binding schema to the data, the late binding schema associated with one or more extraction rules defining one or more fields. 10. The method of claim 1, wherein the portion of searchable data includes machine data generated by at least one of a server, a database, an application, or a network. 11. The method of claim 1, wherein the search query is execute in near real-time. 12. The method of claim 1, wherein the search query is executed on a schedule that is associated with the alert. 13. The method of claim 1, wherein the search query and triggering condition together evaluate portions of the searchable data falling within a rolling time window. 14. The method of claim 1, wherein the triggering condition requires that the portion of the dataset includes at least a predetermined number of results. 15. The method of claim 1, wherein the triggering condition comprises a secondary conditional search on the dataset produced by the search query. 16. The method of claim 1, further comprising: preforming at least one action associated with the alert, wherein the action includes: sending an electronic mail message, creating a Really Simple Syndication (RSS) feed, executing a script, or causing visual display of the alert instance. 17. A computer system comprising: a memory; and one or more processing devices, coupled to the memory, to: execute a search query on a portion of searchable data associated with a time window to produce a dataset comprising one or more results; responsive to determining that at least a portion of the dataset satisfies a triggering condition defining an alert associated with the search query, generate an instance of the alert; associate, by a memory data structure, the instance of the alert with an identifier of the search query and a time parameter specifying the time window; receive, from a client computing device, a request for the portion of the dataset; and responsive to determining that the portion of the dataset is not stored in the memory in a manner associating it with the instance of the alert, reproduce the portion of the dataset by re-executing the search query in view of the time parameter. 18. The computer system of claim 17, wherein the processing devices are further to: store, in a memory associated with the computer system, the portion of the dataset and an association of the stored portion of the dataset with the instance of the alert. 19. The computer system of claim 17, wherein the processing devices are further to: implement a file retention policy with respect to datasets stored in the memory, wherein the file retention policy requires deleting certain datasets responsive to evaluating corresponding file retention conditions. 20. The computer system of claim 17, wherein the processing devices are further to: transmit the copy of the portion of the dataset to the client computing device. 21. The computer system of claim 17, wherein the processing devices are further to: associate the instance of the alert with an identifier of the triggering condition. 22. The computer system of claim 17, wherein the searchable data includes time-stamped events having portions of raw machine data. 23. The computer system of claim 17, wherein the processing devices are further to: transmit, to the client computing device, a notification of the instance of the alert. 24. The computer system of claim 17, wherein executing the search query on the portion of searchable data includes applying a late binding schema to the data, the late binding schema associated with one or more extraction rules defining one or more fields. 25. A computer-readable non-transitory storage medium comprising executable instructions that, when executed by a computer system, cause the computer system to perform operations comprising: executing a search query on a portion of searchable data associated with a time window to produce a dataset comprising one or more results; responsive to determining that at least a portion of the dataset satisfies a triggering condition defining an alert associated with the search query, generating an instance of the alert; associating, by a memory data structure, the instance of the alert with an identifier of the search query and a time parameter specifying the time window; receiving, from a client computing device, a request for the portion of the dataset; and responsive to determining that the portion of the dataset is not stored in the memory in a manner associating it with the instance of the alert, reproducing the portion of the dataset by re-executing the search query in view of the time parameter. 26. The computer-readable non-transitory storage medium of claim 25, further comprising executable instructions causing the computer system to: store, in a memory associated with the computer system, the portion of the dataset and an association of the stored portion of the dataset with the instance of the alert. 27. The computer-readable non-transitory storage medium of claim 25, further comprising executable instructions causing the computer system to: implement a file retention policy with respect to datasets stored in the memory, wherein the file retention policy requires deleting certain datasets responsive to evaluating corresponding file retention conditions. 28. The computer-readable non-transitory storage medium of claim 25, further comprising executable instructions causing the computer system to: transmit the copy of the portion of the dataset to the client computing device. 29. The computer-readable non-transitory storage medium of claim 25, further comprising executable instructions causing the computer system to: associate the instance of the alert with an identifier of the triggering condition. 30. The computer-readable non-transitory storage medium of claim 25, further comprising executable instructions causing the computer system to: transmit, to the client computing device, a notification of the instance of the alert."
14416282,"A scan driving circuit is provided. The scan driving circuit includes a pull-up control module, a pull-up module, a pull-down module, a pull-down maintenance module, a bootstrap capacitor, and a low-level constant source. The pull-up control module herein is respectively coupled to the pull-up module, the pull-down module, the pull-down maintenance module, and the bootstrap capacitor; the low-level constant source is respectively coupled to the pull-down maintenance module and the pull-down module. The present invention can avoid a leakage phenomenon well and improve reliability of the scan driving circuit.","1. A scan driving circuit for driving a scan line of cascaded stages, comprising: a pull-up control module utilized to receive a scanning signal of a previous stage, and to generate a scan level signal of the corresponding scan line according to the scanning signal of the previous stage; a pull-up module utilized to lift a scanning signal of a present stage of the corresponding scan line according to the scan level signal and a clock signal of the present stage; a pull-down module utilized to lower the scan level signal of the corresponding scan line according to a scanning signal of a next stage; a pull-down maintenance module utilized to maintain a low level of the scan level signal of the corresponding scan line; a bootstrap capacitor utilized to a high level of the scanning signal of the present stage of the scan line; a reset module utilized to reset the scan level signal of the present stage of the scan line; and a low-level constant source utilized to provide a pull-down low level; wherein the pull-up control module is respectively coupled to the pull-up module, the pull-down module, the pull-down maintenance module, and the bootstrap capacitor; the low-level constant source is respectively coupled to the pull-down maintenance module and the pull-down module; wherein the pull-up control module further comprises a first switch, the scanning signal of the previous stage being input to a control terminal of the first switch, the scanning signal of the previous stage being input to an input terminal the first switch, an output terminal of the first switch respectively coupled to the pull-up module, the pull-down module, the pull-down maintain module, and the bootstrap capacitor. 2. The scan driving circuit according to claim 1, wherein the pull-up module comprises a second switch, a control terminal of the second switch coupled to the output terminal of the first switch of the pull-up control module, the clock signal of the present stage being input to an input terminal of the second switch, an output terminal of the second switch outputting the scanning signal of the present stage. 3. The scan driving circuit according to claim 1, wherein the pull-down module comprises a third switch, the scanning signal of the next stage being input to a control terminal of the third switch, an input terminal of the third switch coupled to the output terminal of the first switch of the pull-up control module, an output terminal of the third switch coupled to the low-level constant source. 4. The scan driving circuit according to claim 1, wherein the pull-down maintenance module comprises a first pull-down maintenance unit, a second pull-down maintenance unit, a thirteenth switch, and a fourteenth switch; a control terminal of the thirteenth switch coupled to the output terminal of the first switch, an output terminal of the thirteenth switch coupled to a reference point K(N), an input terminal of the thirteenth switch coupled to a reference point P(N); the scanning signal of the previous stage being input to a control terminal of the fourteenth switch, an output terminal of the fourteenth switch coupled to the reference point K(N), an input terminal of the fourteenth switch coupled to the reference point P(N); the first pull-down maintenance unit comprising a ninth switch, a tenth switch, a sixth switch, an eighth switch, a sixteenth switch; a control terminal of the tenth switch coupled to the reference point K(N), an input terminal of the tenth switch coupled to the low-level constant source, an output terminal of the tenth switch coupled to the output terminal of the second switch; a control terminal of the ninth switch coupled to the reference point K(N), an input terminal of the ninth switch coupled to the low-level constant source, an output terminal of the ninth switch coupled to the output terminal of the first switch; a control terminal of the sixth switch coupled to a first pulse signal, an input terminal of the sixth switch coupled to the first pulse signal, an output terminal of the sixth switch coupled to the reference point K(N); a control terminal of the sixteenth switch coupled to a second pulse signal, an input terminal of the sixteenth switch coupled to the first pulse signal, an output terminal of the sixteenth switch coupled to the reference point K(N); a control terminal of the eighth switch coupled to the output terminal of the first switch, an input terminal of the eighth switch coupled to the low-level constant source, an output terminal of the eighth switch coupled to the reference point K(N); the second pull-down maintenance unit comprising an eleventh switch, a twelfth switch, a fifth switch, a fifteenth switch, and a seventh switch; a control terminal of the eleventh switch coupled to the reference point P(N), an input terminal of the eleventh switch coupled to the low-level constant source, an output terminal of the eleventh switch coupled to the output terminal of the second switch; a control terminal of the twelfth switch coupled to the reference point P(N), an input terminal of the twelfth switch coupled to the low-level constant source, an output terminal of the twelfth switch coupled to the output terminal of the first switch; a control terminal of the fifth switch coupled to the second pulse signal, an input terminal of the fifth switch coupled to the second pulse signal, an output terminal of the fifth switch coupled to the reference point P(N); a control terminal of the fifteenth switch coupled to the first pulse signal, an input terminal of the fifteenth switch coupled to the second pulse signal, an output terminal of the fifteenth switch coupled to the reference point P(N); a control terminal of the seventh switch coupled to the output terminal of the first switch, an input terminal of the seventh switch coupled to the low-level constant source, an output terminal of the seventh switch coupled to the reference point K(N). 5. The scan driving circuit according to claim 4, wherein an electric potential of the first pulse signal is opposite to that of the second pulse signal. 6. The scan driving circuit according to claim 4, wherein the first pull-down maintain further comprises an eighteenth switch, the scanning signal of the previous stage being input to a control terminal of the eighteenth switch, an input terminal of the eighteenth switch coupled to the low-level constant source, an output terminal of the eighteenth switch coupled to the reference point K(N); the second pull-down maintain further comprises an seventeenth switch, the scanning signal of the previous stage being input to a control terminal of the seventeenth switch, an input terminal of the seventeenth switch coupled to the low-level constant source, an output terminal of the seventeenth switch coupled to the reference point P(N). 7. The scan driving circuit according to claim 4, wherein the first pull-down maintain further comprises an eighteenth switch, the scanning signal of the previous stage being input to a control terminal of the eighteenth switch, an input terminal of the eighteenth switch coupled to the low-level constant source, an output terminal of the eighteenth switch coupled to the first pulse signal; the second pull-down maintain further comprises an seventeenth switch, the scanning signal of the previous stage being input to a control terminal of the seventeenth switch, an input terminal of the seventeenth switch coupled to the low-level constant source, an output terminal of the seventeenth switch coupled to the second pulse signal. 8. The scan driving circuit according to claim 7, wherein the first pull-down maintain further comprises a twentieth switch, a control terminal of the twentieth switch coupled to the reference point K(N), an input terminal of the twentieth switch coupled to the reference point K(N), an output terminal of the twentieth switch coupled to the first pulse signal; the second pull-down maintain further comprises a nineteenth switch, a control terminal of the nineteenth switch coupled to the reference point K(N), an input terminal of the nineteenth switch coupled to the reference point K(N), an output terminal of the nineteenth switch coupled to the second pulse signal. 9. The scan driving circuit according to claim 4, wherein the first pulse signal and the second pulse signal are high-frequency pulse signals or low-frequency potential signals. 10. A scan driving circuit for driving a plurality of scan lines of cascaded stages, comprising: a pull-up control module utilized to receive a scanning signal of a previous stage, and to generate a scan level signal of the corresponding scan line according to the scanning signal of the previous stage; a pull-up module utilized to lift a scanning signal of a present stage of the corresponding scan line according to the scan level signal and a clock signal of the present stage; a pull-down module utilized to lower the scan level signal of the corresponding scan line according to a scanning signal of a next stage; a pull-down maintenance module utilized to maintain a low level of the scan level signal of the corresponding scan line; a bootstrap capacitor utilized to a high level of the scanning signal of the present stage of the scan line; and a low-level constant source utilized to provide a pull-down low level; wherein the pull-up control module is respectively coupled to the pull-up module, the pull-down module, the pull-down maintenance module, and the bootstrap capacitor; the low-level constant source is respectively coupled to the pull-down maintenance module and the pull-down module. 11. The scan driving circuit according to claim 10, wherein the pull-up control module further comprises a first switch, the scanning signal of the previous stage being input to a control terminal of the first switch, the scanning signal of the previous stage being input to an input terminal the first switch, an output terminal of the first switch respectively coupled to the pull-up module, the pull-down module, the pull-down maintain module, and the bootstrap capacitor. 12. The scan driving circuit according to claim 11, wherein the pull-up module comprises a second switch, a control terminal of the second switch coupled to the output terminal of the first switch of the pull-up control module, the clock signal of the present stage being input to an input terminal of the second switch, an output terminal of the second switch outputting the scanning signal of the present stage. 13. The scan driving circuit according to claim 11, wherein the pull-down module comprises a third switch, the scanning signal of the next stage being input to a control terminal of the third switch, an input terminal of the third switch coupled to the output terminal of the first switch of the pull-up control module, an output terminal of the third switch coupled to the low-level constant source. 14. The scan driving circuit according to claim 11, wherein the pull-down maintenance module comprises a first pull-down maintenance unit, a second pull-down maintenance unit, a thirteenth switch, and a fourteenth switch; a control terminal of the thirteenth switch coupled to the output terminal of the first switch, an output terminal of the thirteenth switch coupled to a reference point K(N), an input terminal of the thirteenth switch coupled to a reference point P(N); the scanning signal of the previous stage being input to a control terminal of the fourteenth switch, an output terminal of the fourteenth switch coupled to the reference point K(N), an input terminal of the fourteenth switch coupled to the reference point P(N); the first pull-down maintenance unit comprising a ninth switch, a tenth switch, a sixth switch, an eighth switch, a sixteenth switch; a control terminal of the tenth switch coupled to the reference point K(N), an input terminal of the tenth switch coupled to the low-level constant source, an output terminal of the tenth switch coupled to the output terminal of the second switch; a control terminal of the ninth switch coupled to the reference point K(N), an input terminal of the ninth switch coupled to the low-level constant source, an output terminal of the ninth switch coupled to the output terminal of the first switch; a control terminal of the sixth switch coupled to a first pulse signal, an input terminal of the sixth switch coupled to the first pulse signal, an output terminal of the sixth switch coupled to the reference point K(N); a control terminal of the sixteenth switch coupled to a second pulse signal, an input terminal of the sixteenth switch coupled to the first pulse signal, an output terminal of the sixteenth switch coupled to the reference point K(N); a control terminal of the eighth switch coupled to the output terminal of the first switch, an input terminal of the eighth switch coupled to the low-level constant source, an output terminal of the eighth switch coupled to the reference point K(N); the second pull-down maintenance unit comprising an eleventh switch, a twelfth switch, a fifth switch, a fifteenth switch, and a seventh switch; a control terminal of the eleventh switch coupled to the reference point P(N), an input terminal of the eleventh switch coupled to the low-level constant source, an output terminal of the eleventh switch coupled to the output terminal of the second switch; a control terminal of the twelfth switch coupled to the reference point P(N), an input terminal of the twelfth switch coupled to the low-level constant source, an output terminal of the twelfth switch coupled to the output terminal of the first switch; a control terminal of the fifth switch coupled to the second pulse signal, an input terminal of the fifth switch coupled to the second pulse signal, an output terminal of the fifth switch coupled to the reference point P(N); a control terminal of the fifteenth switch coupled to the first pulse signal, an input terminal of the fifteenth switch coupled to the second pulse signal, an output terminal of the fifteenth switch coupled to the reference point P(N); a control terminal of the seventh switch coupled to the output terminal of the first switch, an input terminal of the seventh switch coupled to the low-level constant source, an output terminal of the seventh switch coupled to the reference point K(N). 15. The scan driving circuit according to claim 14, wherein an electric potential of the first pulse signal is opposite to that of the second pulse signal. 16. The scan driving circuit according to claim 14, wherein the first pull-down maintain further comprises an eighteenth switch, the scanning signal of the previous stage being input to a control terminal of the eighteenth switch, an input terminal of the eighteenth switch coupled to the low-level constant source, an output terminal of the eighteenth switch coupled to the reference point K(N); the second pull-down maintain further comprises an seventeenth switch, the scanning signal of the previous stage being input to a control terminal of the seventeenth switch, an input terminal of the seventeenth switch coupled to the low-level constant source, an output terminal of the seventeenth switch coupled to the reference point P(N). 17. The scan driving circuit according to claim 14, wherein the first pull-down maintain further comprises an eighteenth switch, the scanning signal of the previous stage being input to a control terminal of the eighteenth switch, an input terminal of the eighteenth switch coupled to the low-level constant source, an output terminal of the eighteenth switch coupled to the first pulse signal; the second pull-down maintain further comprises an seventeenth switch, the scanning signal of the previous stage being input to a control terminal of the seventeenth switch, an input terminal of the seventeenth switch coupled to the low-level constant source, an output terminal of the seventeenth switch coupled to the second pulse signal. 18. The scan driving circuit according to claim 17, wherein the first pull-down maintain further comprises a twentieth switch, a control terminal of the twentieth switch coupled to the reference point K(N), an input terminal of the twentieth switch coupled to the reference point K(N), an output terminal of the twentieth switch coupled to the first pulse signal; the second pull-down maintain further comprises a nineteenth switch, a control terminal of the nineteenth switch coupled to the reference point K(N), an input terminal of the nineteenth switch coupled to the reference point K(N), an output terminal of the nineteenth switch coupled to the second pulse signal. 19. The scan driving circuit according to claim 14, wherein the first pulse signal and the second pulse signal are high-frequency pulse signals or low-frequency potential signals. 20. The scan driving circuit according to claim 10, wherein the scan driving circuit further comprises: a reset module utilized to reset the scan level signal of the present stage of the scan line."
14774293,"The present invention relates to an antibody construct comprising a first human binding domain specific for the extracellular part of the influenza envelope protein M2 (M2e) and a second domain specific for CD3. Moreover, the invention provides a nucleic acid molecule encoding the antibody construct, a vector comprising said nucleic acid molecule and a host cell transformed or transfected with said nucleic acid molecule or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a pharmaceutical composition comprising said antibody construct, a medical use/method of treatment relating to said antibody construct, and a kit comprising said antibody construct.","1. An antibody construct comprising: (a) a first human binding domain specific for the extracellular part of the influenza envelope protein M2 (M2e), characterized by a CDR-H1 as depicted in SEQ ID NO: 1, a CDR-H2 as depicted in SEQ ID NO: 2, a CDR-H3 as depicted in SEQ ID NO: 3, a CDR-L1 as depicted in SEQ ID NO: 4, a CDR-L2 as depicted in SEQ ID NO: 5, and a CDR-L3 as depicted in SEQ ID NO: 6; and (b) a second binding domain specific for CD3. 2. The antibody construct according to claim 1, wherein the first binding domain comprises a VH region selected from the group consisting of VH regions as depicted in SEQ ID NO: 8, 16, 24, 32, 40, 48, 56, 64, and 72. 3. The antibody construct according to claim 1 or 2, wherein the first binding domain comprises a VL region selected from the group consisting of VL regions as depicted in SEQ ID NO: 10, 18, 26, 34, 42, 50, 58, 66, and 74. 4. The antibody construct according to any one of the preceding claims, wherein the first binding domain comprises a VH region and a VL region selected from the group consisting of pairs of a VH region and a VL region as depicted in SEQ ID NO: 8+10, SEQ ID NO: 16+18, SEQ ID NO: 24+26, SEQ ID NO: 32+34, SEQ ID NO: 40+42, SEQ ID NO: 48+50, SEQ ID NO: 56+58, SEQ ID NO: 64+66 and SEQ ID NO: 72+74. 5. The antibody construct according to any one of the preceding claims, wherein the antibody construct is in a format selected from the group consisting of (scFv)2, scFv-single domain mAb, diabodies and oligomers thereof. 6. The antibody construct according to claim 5, wherein the first binding domain comprises an amino acid sequence selected from the group consisting of SEQ ID NO: 12, 20, 28, 36, 44, 52, 60, 68, and 76. 7. The antibody construct according to any one of the preceding claims, wherein the second binding domain is capable of binding to human and Callithrix jacchus, Saguinus Oedipus or Saimiri sciureus CD3 epsilon. 8. The antibody construct according claim 7, having the amino acid sequence selected from the group consisting of SEQ ID NO: 14, 22, 30, 38, 46, 54, 62, 70 and 78. 9. A nucleic acid molecule having a sequence which encodes an antibody construct as defined in any one of claims 1 to 8. 10. A vector comprising a nucleic acid molecule as defined in claim 9. 11. A host cell transformed or transfected with the nucleic acid molecule as defined in claim 9 or with the vector as defined in claim 10. 12. A process for the production of an antibody construct according to any one of claims 1 to 8, said process comprising culturing a host cell as defined in claim 11 under conditions allowing the expression of the antibody construct as defined in any one of claims 1 to 8 and recovering the produced antibody construct from the culture. 13. A pharmaceutical composition comprising an antibody construct according to any one of claims 1 to 8, or produced according to the process of claim 12. 14. The antibody construct according to any one of claims 1 to 8, or produced according to the process of claim 12 for use in the treatment, amelioration or future prevention of an infection with influenza A virus. 15. A method for the treatment, amelioration or future prevention of an infection with influenza A virus, comprising the step of administering to a subject in need thereof the antibody construct according to any one of claims 1 to 8, or produced according to the process of claim 12. 16. The method according to claim 15, further comprising the step of administering a reactive oxygen scavenger. 17. A pharmaceutical composition comprising a bispecific antibody construct according to any one of claims 1 to 8, or produced according to the process of claim 12 and a reactive oxygen scavenger for the amelioration or treatment of an influenza A virus infection. 18. A kit comprising an antibody construct according to any one of claims 1 to 8, or produced according to the process of claim 12, a vector as defined in claim 10, and/or a host cell as defined in claim 11."
14777214,"The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition genes implicated in many diseases.","1. An oligonucleotide that hybridizes to a non-coding region in or upstream of a promoter for a target gene, wherein the oligonucleotide comprises: a length of 20-34 bases; at least one CG pair; at least 40% C and G content; no more than five consecutive bases of the same nucleotide; and at least one secondary structure for said oligonucleotide. 2. The oligonucleotide of claim 1, wherein said oligonucleotide comprises a C and G content of at least 50%. 3. The oligonucleotide of claim 1, wherein said oligonucleotide comprises a C and G content from about 50 to 80%. 4. The oligonucleotide of claim 1, wherein said oligonucleotide comprises at least two CG pairs. 5. The oligonucleotide of claim 1, wherein said oligonucleotide hybridizes within a CG region, CpG island region, nuclease hypersensitive site, or CIS regulatory region. 6. The oligonucleotide of claim 1, wherein said non-coding region is located within a CG region, CpG island, nuclease hypersensitive site, or CIS regulatory region. 7. The oligonucleotide of claim 1, wherein said oligonucleotide is a reverse and full complement of a sense strand of said non-coding region of the target gene. 8. The oligonucleotide of claim 1, wherein said oligonucleotide is unique to the nucleotide sequence of the non-coding region. 9. The oligonucleotide of claim 1, wherein the nucleotide sequence of the non-coding region is not duplicated in a genome comprising the target gene. 10. The oligonucleotide of claim 1, wherein the nucleotide sequence of the non-coding region comprises less than 80% homology to other nucleotide sequences in a genome with a target gene. 11. The oligonucleotide of claim 1, wherein the nucleotide sequence of the non-coding region comprises less than 50% homology to other nucleotide sequences in a genome with a target gene. 12. The oligonucleotide of claim 1, wherein said oligonucleotide comprises at least four bases in a linear section of the secondary structure. 13. The oligonucleotide of claim 1, wherein said oligonucleotide comprises at least five bases in a linear section of the secondary structure. 14. The oligonucleotide of claim 1, wherein said oligonucleotide comprises at least one CG pair within the first 40% of the bases of said oligonucleotide. 15. The oligonucleotide of claim 1, wherein said oligonucleotide comprises at least one CG pair within the first 50% of the bases of said oligonucleotide. 16. The oligonucleotide of claim 1, wherein said oligonucleotide further comprises at least one CG pair that is prior to or in the nonlinear section of the secondary structure. 17. The oligonucleotide of claim 1, wherein said oligonucleotide comprises a linear section before a secondary structure, no oligonucleotides that extend beyond the secondary structure, and at least one CG pair within the linear section or the secondary structure. 18. The oligonucleotide of claim 1, wherein said oligonucleotide has a linear section before a secondary structure and no oligonucleotides that extend beyond the secondary structure 19. The oligonucleotide of claim 1, wherein said oligonucleotide does not comprise a single G or T base after the nonlinear section of the secondary structure. 20. The oligonucleotide of claim 1, wherein said secondary structure comprises at least one hairpin loop. 21. The oligonucleotide of claim 1, wherein said secondary structure comprises at least two hairpin loops. 22. The oligonucleotide of claim 19 or 20, wherein said secondary structure comprises at least three nucleotide bridges in the nonlinear section of the secondary structure. 23. The oligonucleotide of claim 1, wherein said oligonucleotide comprises a theoretical ΔG between −0.1 to −7. 24. The oligonucleotide of claim 23, wherein said theoretical ΔG is between −1 to −5. 25. The oligonucleotide of claim 1, wherein said oligonucleotide comprises a theoretical ΔTm between 30-70 degrees Celsius. 26. The oligonucleotide of claim 1, wherein said oligonucleotide begins at the 5′ end with the bases selected from CG, CGG, CGC, CGT, CGA, GCG, CCC, CCG, GTC, TCC, TCG, ACG, CAC, CAG, GAG, AGA, GAC, GAA, AGC, or GCC. 27. The oligonucleotide of claim 1, wherein said oligonucleotide ends at the 3′ end with the bases selected from CG, GCG, GGC, CGG, GCC, CGC, CCG, ACG, TCG, GGG, TGC, CCC, GTG, or CTC. 28. The oligonucleotide of claim 1, wherein said non-coding region is located less than 7000 bases upstream of the coding region of the target gene. 29. The oligonucleotide of claim 1, wherein said non-coding region is located less than 5000 bases upstream of the coding region of the target gene. 30. The oligonucleotide of claim 1, wherein said non-coding region is located less than 3000 bases upstream of the coding region of the target gene. 31. The oligonucleotide of claim 1, wherein said non-coding region is located less than 1000 bases upstream of the coding region of the target gene. 32. The oligonucleotide of claim 1, wherein said non-coding region is located less than 500 bases up- or downstream of a transcription factor binding site or translocation site of target gene. 33. The oligonucleotide of claim 1, wherein said non-coding region is located less than 100 bases up- or downstream of a transcription factor binding site or translocation site of target gene. 34. The oligonucleotide of claim 1, wherein said oligonucleotide does not comprise a CpG Coley motif. 35. The oligonucleotide of claim 1, wherein said oligonucleotide does not form a triplex structure. 36. The oligonucleotide of claim 1, wherein said oligonucleotide does not form a G-quadruplex structure. 37. The oligonucleotide of claim 1, wherein said oligonucleotide is a single stranded DNA. 38. The oligonucleotide of claim 1, wherein said oligonucleotide hybridizes to an Sp1 motif or transcription factor binding site. 39. The oligonucleotide of claim 1, wherein said target gene is selected from Survivin, Beclin-1, STAT3, HIF1A, IL-8, KRAS, MTTP, ApoC III, ApoB, IL-17, MMP2, FAP, P-selectin, IL-6, IL-23, AKT, CRAF, Beta-catenin, PCSK9, MEK1, MEK2, CD4, WNT1, Clusterin, NRAS, EZH2, HDAC1, PD-1, TNFα, MIF1, TTR, HBV, HAMP, ERBB2, PARP1, ITGA4, APP, FGFR1, CD68, ALK, MSI2, JAK2, CCND1, or selected from Table 2. 40. The oligonucleotide of claim 1, wherein said oligonucleotide is selected from the group consisting of any of the sequences disclosed in Table 3. 41. The oligonucleotides of claim 1, wherein said oligonucleotide hybridizes to a hot zone of a target gene. 42. The oligonucleotide of claim 1, wherein at least one of the cytosine bases in said oligonucleotide is 5-methylcytosine. 43. The oligonucleotide of claim 1, wherein at least one of the cytosine bases in said CG pair is 5-methylcytosine. 44. The oligonucleotide of claim 1, wherein all of said cytosine bases in said oligonucleotide are 5-methylcytosine. 45. The oligonucleotide of claim 1, wherein said hybridization of said oligonucleotide to the non-coding region modulates the target gene. 46. The oligonucleotide of claim 1, wherein said hybridization of said oligonucleotide to the non-coding region of the target gene modulates expression or transcription of said target gene. 47. The oligonucleotide of claim 1, wherein said hybridization of said oligonucleotide to the non-coding region of the target gene modulates a cell signaling pathway. 48. The oligonucleotide of claim 1, wherein said hybridization of said oligonucleotide to the non-coding region of said target gene produces phenotypic changes in a mammal. 49. The oligonucleotide of claim 1, wherein said hybridization of said oligonucleotide to the non-coding region of said target gene influences a non-gene target due to a chromosomal rearrangement. 50. The oligonucleotide of claim 1, wherein said target gene is on a chromosome of a cell, and wherein said hybridization of said oligonucleotide to said non-coding region reduces proliferation of said cell. 51. The oligonucleotide of claim 1, wherein said target gene is an oncogene. 52. A composition comprising an oligonucleotide according to any one of claims 1-51 and a pharmaceutically acceptable carrier. 53. The composition of claim 52, wherein the pharmaceutically acceptable carrier is a liposome. 54. The composition of claim 53, wherein the liposome is an amphoteric liposome. 55. The composition of claim 53, wherein the liposome comprises a neutral lipid. 56. The composition of claim 53, wherein the liposome comprises a mixture of neutral lipids and lipids with amphoteric properties, wherein the mixture of lipid components comprises anionic and cationic properties and at least one such component is pH responsive. 57. The composition according to any one of claims 52-56, wherein the composition further comprises an additional therapeutic agent. 58. The composition of claim 57, wherein the additional therapeutic agent is a second oligonucleotide, chemotherapeutic agent, immunotherapeutic agent, or radiotherapy. 59. The composition of claim 52, wherein said composition has two (2) therapeutic agents. 60. The composition of claim 59, wherein one therapeutic agent treats a cancer disease and the other therapeutic agent treats a non-cancer disease. 61. A method of inhibiting protein expressing in a cell with a target gene comprising introducing into said cell an oligonucleotide according to any one of claims 1-51 or composition according to any one of claims 52-60. 62. A method of mediating target-specific RNA in a mammalian cell in vitro, comprising contacting said mammalian cell in vitro with an oligonucleotide according to any one of claims 1-51 or composition according to any one of claims 52-60. 63. A method of mediating protein down regulation in a mammalian cell in vitro, comprising contacting said mammalian cell in vitro with an oligonucleotide according to any one of claims 1-51 or composition according to any one of claims 52-60. 64. A method of treating a patient having a disease characterized by the presence or undesired production of a protein implicated in said disease, comprising administering to said patient a pharmaceutically effective amount of an oligonucleotide according to any one of claims 1-51 or composition according to any one of claims 52-60. 65. A method of treating a patient having a disease characterized by the presence or undesired production of a protein implicated in said disease, comprising administering to said patient a pharmaceutically effective amount between 1 mg/m2 and 500 mg/m2 of an oligonucleotide according to any one of claims 1-51 or composition according to any one of claims 52-60. 66. A method of treating a mammal having a disease characterized by the presence or undesired production of a protein implicated in disease, comprising administering to said mammal a pharmaceutically effective amount of an oligonucleotide according to any one of claims 1-51 or composition according to the description and the compositions in any of claims 52-60. 67. A method of treating a plant having a disease characterized by the presence or undesired production of a protein implicated in disease, comprising introducing to said plant an effective amount of an oligonucleotide according to any one of claims 1-51 or composition according to the description and the compositions in any of claims 52-60. 68. A method of administration of a therapeutic disclosed herein and a oligonucleotide according to any one of claims 1-51 or a composition according to any one of claim 52-60, wherein said administration is through a route selected from oral, vapor, inhalation, dermal, subdermal, subcutaneous, parental, parenterally, ear, nose, nasally, bucally, eye, otic, ophthalmically, rectal, vaginal, suppository or implant, implanted reservoir, dermal, dermal skin patch, injection, or sub-lingual. 69. A method or kit for a diagnosis and treatment of a disease comprising the steps of administering to a patient a pharmaceutically effective amount of an oligonucleotides accordingly to any one of claims 1-51 or a composition according to any one of claims 52-60, wherein the patient is characterized by the presence of, or undesired production of, a protein implicated in said disease, and the method further comprising evaluating said patient for the presence of, or undesired production of said protein. 70. An single stranded DNA oligonucleotide that hybridizes to coding or non-coding region of a target gene, wherein the oligonucleotide comprises: a length of 12-50 bases; at least 30% C and G content; and no more than seven consecutive bases of the same nucleotide. 71. The oligonucleotide of claim 70, wherein the nucleotide sequence of the non-coding region comprises less than 80% homology to other nucleotide sequences in a genome with a target gene. 72. The oligonucleotide of claim 70, wherein said oligonucleotide comprises at least one CG pair within the first 40% of the bases of said oligonucleotide. 73. The oligonucleotide of claim 70 further comprising a secondary structure. 74. The oligonucleotide of claim 70, wherein said oligonucleotide comprises a theoretical ΔG between −0.1 to −7. 75. The oligonucleotide of claim 70, wherein said oligonucleotide comprises a theoretical ΔTm between 30-70 degrees Celsius. 76. The oligonucleotide of claim 70, wherein said non-coding region is located less than 7000 bases upstream of the coding region of the target gene. 77. The oligonucleotide of claim 70, wherein said non-coding region is located less than 500 bases up- or downstream of a transcription factor binding site or translocation site of target gene. 78. The oligonucleotide of claim 70, wherein said non-coding region is located with a CG region, nuclease hypersensitive site, or CpG island of the genome comprising the target gene. 79. The oligonucleotide of claim 70, further comprises at least one CG pair and optionally at least one of the cytosine bases in said CG pair is 5-methylcytosine. 80. The oligonucleotide of claim 70, wherein said target gene is on a chromosome of a cell, and wherein said hybridization of said oligonucleotide reduces proliferation of said cell. 81. A composition comprising an oligonucleotide according to any one of claims 70-80 and a pharmaceutically acceptable carrier. 82. The composition of claim 81, wherein the pharmaceutically acceptable carrier is a liposome. 83. The composition according to any one of claim 81 or 82 wherein the composition further comprises an additional therapeutic agent. 84. A method of inhibiting or silencing gene transcription in a cell with a target gene comprising introducing into said cell an oligonucleotide according to any one of claims 70-80 or composition according to any one of claims 81-83. 85. A method of mediating target-specific RNA in a mammalian cell in vitro, comprising contacting said mammalian cell in vitro with an oligonucleotide according to any one of claims 70-80 or composition according to any one of claims 81-83."
14781534,"A spacer for insulated glazing units having at least one polymeric main body with a wall thickness d having a first pane contact surface and a second pane contact surface running parallel thereto, one first glazing interior surface, one second glazing interior surface, one outer surface, one first hollow chamber, and one second hollow chamber. A groove for receiving a pane runs parallel to the first pane contact surface and the second pane contact surface between the first glazing interior surface and the second glazing interior surface. The first hollow chamber adjoins the first glazing interior surface and the second hollow chamber adjoins the second glazing interior surface. The lateral flanks of the groove are formed by the walls of the first hollow chamber and the second hollow chamber, and the wall thickness d′ in the region of the lateral flanks is less than the wall thickness d of the polymeric main body.","1. A spacer for insulated glazing units, the spacer comprising at least one polymeric main body comprising a first pane contact surface and a second pane contact surface running parallel thereto, a first glazing interior surface, a second glazing interior surface, an outer surface, a first hollow chamber, and a second hollow chamber, wherein a groove configured for receiving a pane runs parallel to the first pane contact surface and the second pane contact surface between the first glazing interior surface and the second glazing interior surface, the first hollow chamber adjoins the first glazing interior surface and the second hollow chamber adjoins the second glazing interior surface, the lateral flanks of the groove are formed by walls of the first hollow chamber and the second hollow chamber, and a wall thickness d′ in the region of the lateral flanks is less than a wall thickness d of the polymeric main body. 2. The spacer for insulated glazing units according to claim 1, wherein the lateral flanks of the groove include an insert. 3. The spacer for insulated glazing units according to claim 1, wherein for the wall thickness d′ in the region of the lateral flanks d′ is <0.7 d. 4. The spacer for insulated glazing units according to claim 1, wherein an insulating foil is applied on the outer surface of the polymeric main body, the insulating foil comprises at least one polymeric layer as well as at least one metallic or ceramic layer which is alternatingly arranged with the at least one polymeric layer. 5. The spacer for insulated glazing units according to claim 1, wherein the polymeric main body contains a desiccant. 6. The spacer for insulated glazing units according to claim 1, wherein the first glazing interior surface or the second glazing interior surface has at least one opening that connects the first and second hollow chambers to the interpane spaces. 7. The spacer for insulated glazing units according to claim 1, wherein the polymeric main body contains polyethylene, polycarbonates, polypropylene, polystyrene, polybutadiene, polynitriles, polyesters, polyurethanes, polymethyl methacrylates, polyacrylates, polyamides, polyethylene terephthalate, polybutylene terephthalate, preferably acrylonitrile butadiene styrene, acrylonitrile styrene acrylester, acrylonitrile butadiene styrene/polycarbonate, styrene acrylonitrile, PET/PC, PBT/PC, or copolymers or mixtures thereof. 8. An insulated glazing unit comprising at least one first pane, one second pane, and one third pane, and one peripheral spacer surrounding the panes, the peripheral spacer being the spacer according to claim 1, wherein the first pane contacts the first pane contact surface, the second pane contacts the second pane contact surface, and the third pane is inserted into the groove of the spacer. 9. The insulated glazing unit according to claim 8, wherein a gasket is mounted between the first pane and the first pane contact surface or the second pane and the second pane contact surface. 10. The insulated glazing unit according to claim 8, wherein the first pane, the second pane, or the third pane contain glass or polymers or a combination of glass and polymers. 11. The insulated glazing unit according to claim 8, wherein the third pane of the insulated glazing unit is not prestressed. 12. A method for producing the insulated glazing unit according to claim 8, wherein at least the third pane is inserted into the groove of the spacer, the first pane is abutted against the first pane contact surface of the spacer, the second pane is abutted against the second pane contact surface of the spacer, and the pane arrangement of the panes and the spacer is pressed together. 13. The method according to claim 12, wherein, first, the spacer is preformed into a rectangle open on one side, the third pane is pushed into the groove of the spacer, and the remaining edge of the pane is closed with a spacer. 14. The method according to claim 12, wherein the interpane spaces between the first pane and the third pane as well as between the second pane and the third pane are filled with a protective gas. 15. A method of using the spacer according to claim 1 in multipane glazing units. 16. The spacer according to claim 2, wherein the insert comprises an elastomer. 17. The spacer according to claim 16, wherein the elastomer comprises ethylene propylene diene rubber. 18. The spacer according to claim 3, wherein d′ is <0.5 d. 19. The spacer according to claim 4, wherein the at least one metallic or ceramic layer comprises at least two metallic or ceramic layers. 20. The spacer according to claim 5, wherein the desiccant is silica gels, molecular sieves, CaCl2, Na2SO4, activated carbon, silicates, bentonites, zeolites, or mixtures thereof. 21. The spacer according to claim 6, wherein the at least one opening is a plurality of openings. 22. The insulated glazing unit according to claim 9, wherein the gasket comprises a polymer. 23. The insulated glazing unit according to claim 22, wherein the polymer is a silane-modified polymer. 24. The insulated glazing unit according to claim 9, wherein the gasket comprises organic polysulfides, silicones, room temperature vulcanizing silicone rubber, high temperature vulcanizing silicone rubber, peroxide vulcanizing silicone rubber, addition vulcanizing silicone rubber, polyurethanes, butyl rubber, polyacrylates, or a combination thereof. 25. The insulated glass unit according to claim 10, wherein the glass or polymers or a combination of glass and polymers comprises quartz glass, borosilicate glass, soda lime glass, polymethyl methacrylate, or mixtures thereof. 26. The method of claim 15, wherein the multipane glazing units are insulated glazing units. 27. The method of claim 26, wherein the insulated glazing units are triple insulated glazing units."
14782846,"A multilayer sheet includes a first resin layer, a second resin layer, a particle-containing layer disposed at least between the first and second resin layers and including plural particles and gaps formed between the particles, and an intermediate layer disposed at least one selected from between the first resin layer and the particle-containing layer or between the second resin layer and the particle-containing layer, including a copolymer having a weight average molecular weight (Mw) of 300,000 or more and a molecular weight distribution, expressed as a ratio of the weight average molecular weight (Mw) to a number average molecular weight (Mn), of 6.0 or less and a structural moiety derived from a crosslinking agent adapted to crosslink the copolymer, and having a crosslinking density of from more than 0 mol/m3 to 450 mol/m3.","1. A multilayer sheet, comprising: a first resin layer; a second resin layer; a particle-containing layer disposed at least between the first resin layer and the second resin layer, the particle-containing layer comprising a plurality of particles and gaps formed between the particles; and an intermediate layer disposed at at least one selected from (i) between the first resin layer and the particle-containing layer or (ii) between the second resin layer and the particle-containing layer, the intermediate layer comprising a copolymer having a weight average molecular weight (Mw) of 300,000 or more and having a molecular weight distribution (Mw/Mn), expressed as a ratio of a weight average molecular weight (Mw) to a number average molecular weight (Mn), of 6.0 or less, and a structural moiety derived from a crosslinking agent adapted to crosslink the copolymer, and the intermediate layer having a crosslinking density of from more than 0 mol/m3 to 450 mol/m3. 2. The multilayer sheet according to claim 1, wherein the copolymer is a (meth)acrylic copolymer comprising: a structural unit A derived from a (meth)acrylate; and a structural unit B derived from a monomer having at least one functional group selected from a hydroxy group, a carboxy group, a phosphate group, a cyano group, an epoxy group, or an amino group. 3. The multilayer sheet according to claim 1, wherein each of the first resin layer and the second resin layer independently comprises at least one selected from a carbonate resin, a (meth)acrylic resin, an ester resin, a styrene resin, a vinyl chloride resin, a fluorine resin, an olefin resin, a cellulose acetate resin, a silicone resin, an amide resin, an epoxy resin, an acrylonitrile resin, a urethane resin, an imide resin, or a polyether sulfone. 4. The multilayer sheet according to claim 1, wherein the particles have an average particle diameter of from 5 nm to 300 nm. 5. The multilayer sheet according to claim 1, wherein the particles are hollow particles. 6. The multilayer sheet according to claim 1, wherein the intermediate layer has a storage modulus of from 60,000 Pa to 280,000 Pa. 7. The multilayer sheet according to claim 2, wherein a content of the structural unit A in the (meth)acrylic copolymer is from 50% by mole to 99% by mole with respect to a total mole number of monomer-derived structural units in the (meth)acrylic copolymer. 8. The multilayer sheet according to claim 2, wherein a content of the structural unit B in the (meth)acrylic copolymer is from 1% by mole to 50% by mole with respect to a total mole number of monomer-derived structural units in the (meth)acrylic copolymer. 9. The multilayer sheet according to claim 1, wherein at least one layer selected from the first resin layer or the second resin layer is a prism layer or a lens layer."
14783947,"A switching valve for an internal combustion engine, which has an adjustable compression ratio, namely to control a hydraulic oil flow particularly for an eccentric adjustment mechanism, having a control piston, which can be shifted by a switching mechanism similar to a ballpoint pen mechanism, wherein the control piston controls the hydraulic oil flow dependent on the switch position thereof, wherein the switching mechanism comprises at least one actuation element and a detent element, and wherein at least the control piston, the actuation element and the detent element are nested in each other so that they are implemented in a concentrically overlapping manner, at least in sections, when viewed in the shifting direction of the control piston.","1. A switching valve for an internal combustion engine having an adjustable compression ratio, the switching valve is configured to control a hydraulic oil flow an eccentric adjustment mechanism, the switching valve comprising: a control piston configured to be shifted by a switching mechanism wherein the control piston controls the hydraulic oil flow dependent on a switch position thereof, and wherein the switching mechanism includes at least one actuation element and a detent element, wherein at least the control piston, the actuation element and the detent element are nested in each other so that they are implemented in a concentrically overlapping manner, at least in sections, when viewed in a shifting direction of the control piston. 2. The switching valve of claim 1, wherein the control piston concentrically surrounds the actuation element and the detent element, at least in sections, on a radially outer side. 3. The switching valve of claim 2, wherein the actuation element concentrically surrounds the detent element, at least in sections, on the radially outer side. 4. The switching valve of claim 1, wherein the switching mechanism further includes a spring element serving as a restoring element, which concentrically surrounds the actuation element and the detent element, at least in sections, on the radially outer side. 5. The switching valve of claim 4, wherein the spring element extends into a circumferential groove of the control piston and is supported at the control piston. 6. The switching valve of claim 5, wherein the spring element concentrically surrounds a radially inner delimiting wall of the groove, at least in sections, on the radially outer side and that a radially outer delimiting wall of the groove concentrically surrounds the spring element, at least in sections, on a radially outer side. 7. The switching valve of claim 1, wherein the switching mechanism further includes a turning element positioned ahead of or behind the actuation element, when seen in the shifting direction of the control piston. 8. The switching valve of claim 7, wherein the control piston concentrically surrounds the turning element on a radially outer side. 9. The switching valve of claim 7, wherein the turning element concentrically surrounds the detent element, at least in sections, on the radially outer side. 10. The switching valve of claim 7, wherein the actuation element presses against the turning element or that the turning element presses against the actuation element. 11. The switching valve of claim 7, wherein the turning element is configured to be shifted translationally by the actuation element, wherein, when at least one protrusion of the turning element has been moved out of a groove of the detent element, the turning element can be turned with respect to the detent element. 12. The switching valve of claim 7, wherein the control piston connects first ports and separates second ports, when in a first switch position, and that the control piston separates the first ports and connects the second ports, when in a second switch position, such that, in the first switch position, a fluid line coupled with one of the first ports and leading to a first hydraulic chamber of the eccentric adjustment mechanism is coupled with a fluid line for emptying the first hydraulic chamber, which fluid line is coupled with the other of the first ports, and that, in the second switch position, a fluid line coupled with one of the second ports and leading to a second hydraulic chamber of the eccentric adjustment mechanism is coupled with a fluid line for emptying the second hydraulic chamber, which fluid line is coupled with the other of the second ports, wherein one of the other of the first ports and the other of the second ports via which the respective hydraulic chamber can be emptied is provided by a pressure chamber in which, for the actuation of the actuation element, a pressure pulse can be built so that the respective hydraulic chamber is emptied into the pressure chamber that serves to actuate the actuation element. the other of the first ports and the other of the second ports 13. The switching valve of claim 12, wherein both the other of the first ports and the other of the second ports via which the hydraulic chambers can be emptied, are connected with the pressure chamber that serves to actuate the actuation element, so that each of the two hydraulic chambers is respectively emptied against the oil pressure prevailing in the pressure chamber. 14. A method for a switching valve of an internal combustion engine, preferably a switching valve, the internal combustion engine has an adjustable compression ratio, the switching valve configured to control a hydraulic oil flow for an eccentric adjustment mechanism, wherein the switching valve includes a control piston configured to be shifted by a switching mechanism, wherein the hydraulic oil flow is controlled in dependence on a switch position of the control piston, and the switching mechanism includes an actuation element and a detent element, the method comprising at least the following steps: determining the switch position of the switching valve via the control piston, the control piston connects first ports and separates second ports, when in a first switch position, and the control piston separates the first ports and connects the second ports, when in a second switch position, such that, in the first switch position, a fluid line coupled with one of the first ports and leading to a first hydraulic chamber of the eccentric adjustment mechanism is coupled with a fluid line for emptying the first hydraulic chamber, which fluid line is coupled with the other of the first ports, and that, in the second switch position, a fluid line coupled with one of the second ports and leading to a second hydraulic chamber of the eccentric adjustment mechanism is coupled with a fluid line for emptying the second hydraulic chamber, which fluid line is coupled with the other of the second ports, wherein both of the other of the first ports and the other of the second ports via which the respective hydraulic chamber is emptied is provided by a pressure chamber; switching the switching valve between the first switch position and the second switch position by actuating the actuation element by building up an actuation pulse in the pressure chamber; and emptying the respective hydraulic chamber into the pressure chamber that serves to actuate the actuation element. 15. The method of claim 14, wherein both the other of the first ports and the other of the second ports, via which the hydraulic chambers are emptied, are connected with the pressure chamber that serves to actuate the actuation element, so that each of the two hydraulic chambers is respectively emptied against the oil pressure prevailing in the pressure chamber. 16. The method of claim 14, wherein, as the switching valve is transitioned from the first switch position into the second switch position by actuation of the actuation element, the actuation element is pressed against a turning element or the turning element is pressed against the actuation element, wherein the switching mechanism includes the turning element, wherein, as seen in a shifting direction of the control piston, the turning element is positioned ahead of or behind the actuation element, so that the turning element is shifted translationally via the actuation element, wherein the turning element is turned relative to the detent element when at least one projection of the turning element is moved out of a groove of the detent element. 17. The method of claim 14, wherein the actuation element is shifted by the control piston upon a movement of the control piston in dependence on an oil pressure. 18. An internal combustion engine having an adjustable compression ratio, the internal combustion engine comprising: at least one cylinder; and a crankshaft which is engaged by at least one connecting rod, wherein the at least one connecting rod has a crank pin bearing eye that connects the at least one connecting rod with the crankshaft, a piston pin bearing eye that connects the at least one connecting rod with a piston of a cylinder and an eccentric adjustment mechanism that adjusts an effective connecting rod length of the respective at least one connecting rods, wherein the eccentric adjustment mechanism of the respective at least one connecting rods, includes eccentric rods which are subjected to a hydraulic pressure prevailing in hydraulic chambers cooperating with the eccentric rods, and wherein the hydraulic pressure prevailing in the hydraulic chambers of the respective connecting rod is configured to be adjusted via a switching valve of the respective connecting rod, wherein the switching valve of the respective connecting rod is designed as defined in claim 1."
14784626,"This server for distributing messages quickly detects a performance decline in a downstream server by using a method for keeping, for each distribution-destination server, a threshold such as a connection number and a time interval separate from a response timeout, and determining that performance has declined when the threshold is exceeded. In addition, the present invention improves system availability by identifying a server group in which performance has declined on the basis of a correlation pertaining to inter-server cooperative processing, when a distribution server exhibits a decline in performance, and by the distribution server distributing a message to a server not exhibiting a decline in performance.","1. A message system comprising: a message server that receives a message from a message transmitting apparatus and delivers the message to a message receiving apparatus; and data store servers in that each data sore servers stores one or both of the message and relevant information related to the message, wherein the message server includes: a function of managing a status of the each data store server; a function of detecting a decline in performance of the data store server before a response timeout with the data store server occurs; a function of setting a data store server, except for the data store server determined as the decline in the performance, as a storage destination; a function of generating one or both of control information related to storage of the message and the relevant information; and a function of transmitting, to the data store server, one or both of the message and the relevant information and the control information, and wherein the data store server includes: a function of multiply-holding the same data between the plurality of data store servers; a function of performing cooperative processing between the data store servers in order for the multiply holding; and a function of holding one or both of the transmitted message and the transmitted relevant information. 2. The message system according to claim 1, wherein the message server includes a function of acquiring one or both of correlation information of cooperative processing between the data store servers and consultation information based on information exchanged between the data store servers, and wherein the message server has a function of changing a storage destination based on the data store server determined as the decline in the performance and one or both of the correlation information and the consultation information. 3. The message system according to claim 2, wherein the message server includes: a function of determining groups of mutually independent data store servers; and a function of, when the data store server determined as the decline in the performance is detected, setting a data store server belonging to a group separate from the data store server as a storage destination. 4. The message system according to claim 2, wherein the message server includes a function of managing multiplicity of data, and wherein the message server includes a function of changing processing of the message server according to the multiplicity of data. 5. The message system according to claim 2, wherein the message server includes a function of changing a resource limit when the data store server determined as the decline in the performance is detected. 6. The message system according to claim 2, wherein the message server includes a function of operating and managing queues of the data store servers as one queue in an entire system, wherein the message server includes a function of managing one queue of the entire system and the queues of the plurality of data store servers in association with one another, and wherein the message server includes a function of, when a message is stored in one queue of the entire system, searching and selecting a queue of a data store server corresponding thereto. 7. The message system according to claim 1, wherein the message server includes a function of determining an elapsed time from a transmission of a request to the data store server, and detecting a decline in performance of the data store server by exceeding a threshold value. 8. The message system according to claim 1, wherein the message server includes a function of detecting the decline in the performance of the data store server by exceeding a threshold value of the number of simultaneously executed processes or the number of connections so as to transmit a request to the data store server. 9. The message system according to claim 1, wherein the message server includes a function of detecting the decline in the performance of the data store server by exceeding a threshold value of the number of messages waiting for a transmission of a request to the data store server. 10. The message system according to claim 3, wherein the message server includes a function of determining a group of a data store server that is in a service stop, based on one or both of the correlation information and the consultation information, and switching to a group that is not in the service stop. 11. The message system according to claim 3, wherein the plurality of data store servers, which belong to different groups, are arranged in the same apparatus, and wherein an order of setting a queue held within the group as a master is set differently from other groups."
14784716,"There is provided an inorganic fine particle composite body (M) in which a composite resin (A), in which a polysiloxane segment (a1) having a specific structure and a vinyl-based polymer segment (a2) are bonded to each other, and inorganic fine particles (m) are bonded to each other at the polysiloxane segment (a1) through a siloxane bond. There are provided a composition and a hard coat material, containing the inorganic fine particle composite body (M). In addition, there is provided a cured product obtained by curing the composition containing the inorganic fine particle composite body (M) and a laminate containing the cured product.","1. An inorganic fine particle composite body (M), wherein a composite resin (A), in which a polysiloxane segment (a1) having a structural unit represented by General Formula (1) and/or General Formula (2) and a silanol group and/or a hydrolyzable silyl group and a vinyl-based polymer segment (a2) are bonded to each other by a bond represented by General Formula (4), and inorganic fine particles (m) are bonded to each other at the polysiloxane segment (a1) through a siloxane bond: wherein, in General Formulas (1) and (2), each of R1, R2, and R3 independently represents —R4—CH═CH2, —R4—C(CH3)═CH2, —R4—O—CO—C(CH3)═CH2, —R4—O—CO—CH═CH2, a group having a polymerizable double bond selected from the group consisting of groups represented by the following Formula (3) (wherein R4 represents a single bond or an alkylene group having 1 to 6 carbon atoms), an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an aryl group, an aralkyl group having 7 to 12 carbon atoms, or an epoxy group; wherein, in General Formula (3), n is an integer of 1 to 5, and Structure Q represents any one of —CH═CH2 and —C(CH3)═CH2; and wherein, in General Formula (4), the carbon atom constitutes a part of the vinyl-based polymer segment (a2), and the silicon atom bonded only to the oxygen atom constitutes a part of the polysiloxane segment (a1). 2. The inorganic fine particle composite body (M) according to claim 1, wherein the composite resin (A) has a group having a polymerizable double bond. 3. The inorganic fine particle composite body (M) according to claim 1, wherein the composite resin (A) has an epoxy group. 4. The inorganic fine particle composite body (M) according to claim 1, wherein the inorganic fine particles (m) are silica. 5. A method for producing an inorganic fine particle composite body (M), comprising: Step 1 of synthesizing a vinyl-based polymer segment (a2) having a silanol group and/or a hydrolyzable silyl group which is directly bonded to a carbon atom; Step 2 of mixing a silane compound containing a silanol group and/or a hydrolyzable silyl group and inorganic fine particles (m); and Step 3 of condensing the silane compound containing a silanol group and/or a hydrolyzable silyl group. 6. An inorganic fine particle composite body (M), which is obtained by the production method according to claim 5. 7. A composition comprising: the inorganic fine particle composite body (M) according to claim 1. 8. A hard coat material comprising: the composition according to claim 7. 9. A heat resistant material comprising: the composition according to claim 7. 10. A cured product, which is obtained by curing the composition according to claim 7. 11. A laminate comprising: the cured product according to claim 10. 12. A composition comprising: the inorganic fine particle composite body (M) according to claim 2. 13. A composition comprising: the inorganic fine particle composite body (M) according to claim 3. 14. A composition comprising: the inorganic fine particle composite body (M) according to claim 4. 15. A composition comprising: the inorganic fine particle composite body (M) according to claim 6. 16. A hard coat material comprising: the composition according to claim 12. 17. A hard coat material comprising: the composition according to claim 3. 18. A heat resistant material comprising: the composition according to claim 12. 19. A cured product, which is obtained by curing the composition according to claim 12. 20. A laminate comprising: the cured product according to claim 19."
14785458,"Disclosed is a mobile device for executing a radio application (RA) along with a radio interface. The mobile device for executing a radio application includes: a communication service layer (CSL) operated in an application processor or a radio processor for providing at least one of an application administration service, an access control service and a dataflow service; a radio control framework (RCF) operated in the application processor or the radio processor for providing the operational environment of the radio application in linking with the communication service layer; and a multi radio interface (MURI) for enabling the communication service layer to interact with the radio control framework.","1. A terminal apparatus which executes a radio application (RA) and includes an application processor (AP) and a radio processor (RP), the terminal apparatus comprising: a communication service layer (CSL) operating on the AP or the RP, and providing at least one of an administrative service, an access control service, and a data flow service for the RA; a radio control framework (RCF) operating on both of the AP and the RP or on the RP, and providing operation environments for the RA by interworking with the CSL; and a multi radio interface (MURI) for interworking of the CSL and the RCF. 2. The terminal apparatus according to claim 1, wherein the MURI is provided as a multi radio subsystem. 3. The terminal apparatus according to claim 1, wherein the CSL comprises at least one of: an administrator performing at least one of installation/uninstallation of the RA, creating/deleting an instance of the RA, and a request of list information and status information of RAs; a mobility policy manager (MPM) monitoring capabilities and radio environments of the terminal apparatus, and selecting at least one of two or more radio access technologies (RATs); a networking stack sending and receiving user data; and a monitor transmitting context information. 4. The terminal apparatus according to claim 1, wherein the RCF comprises at least one of: a configuration manager (CM) performing installation/uninstallation of the RA, creating/deleting an instance of the RA, and access management of radio parameters for the RA; a radio connection manager (RCM) performing activation/deactivation of the RA and management of user data flow switching between RAs; a flow controller (FC) controlling sending/receiving and a flow of user data packets; a multi-radio controller (MRC) scheduling requests for spectrum resources issued by the RA; and a resource manager (RM) managing radio resources to share them among RAs. 5. The terminal apparatus according to claim 1, wherein the MURI comprises at least one of: an administrative service performing management of the RA, an access control service controlling activation/deactivation of the RA; and a data flow service providing a function of transferring user data of the terminal apparatus or user data received at the terminal apparatus. 6. The terminal apparatus according to claim 5, wherein the administrative service transfers a request of installation or uninstallation of the RA from the CSL to the RCF, transfers confirmation for the request of installation or uninstallation from the RCF to the CSL, and controls the RCF to install or uninstall the RA based on the request of installation or uninstallation. 7. The terminal apparatus according to claim 6, wherein the administrative service transfers at least one of a request of creating or deleting an instance of the RA, a request of parameter configuration, and a request of list information of RAs from the CSL to the RCF, and transfers at least one of confirmation for the request of creating or deleting an instance of the RA, confirmation of the request of parameter configuration, retrieved list information, and information indicating a failure for the at least one request from the RCF to the CSL. 8. The terminal apparatus according to claim 5, wherein the access control service transfers a request of activation or deactivation of the RA from the CSL to the RCF, transfers confirmation for the request of activation or deactivation from the RCF to the CSL, and controls the RCF to activate or deactivate the RA based on the request of activation or deactivation. 9. The terminal apparatus according to claim 8, wherein the access control service transfers at least one of a request of list information of RAs, a request of measurements for radio environments, a request of measurements for the terminal apparatus capabilities, a request of creating a data flow, and a request of network and logical radio link association from the CSL to the RCF, and transfers at least one of retrieved list information, information on the radio environments, information on the terminal apparatus capabilities, confirmation for the request of creating a data flow, confirmation for the network and logical radio link association, and information indicating a failure of the at least one request from the RCF to the CSL. 10. The terminal apparatus according to claim 5, wherein the data flow service transfers the user data of the terminal apparatus from the CSL to the RCF, or transfers the user data received at the terminal apparatus from the RCF to the CSL. 11. The terminal apparatus according to claim 10, wherein the data flow service transfers information indicating a failure of the user data transfer from the RCF to the CSL. 12. The terminal apparatus according to claim 1, wherein the RA comprises: standard function blocks (SFBs) which call function blocks implemented using dedicated hardware logics included in the RP or which operate on a core of the RP; user-defined function blocks (UDFBs) which are not provided as the SFBs or which are customized from functions provided by the SFBs; and a radio controller code performing a function of transmitting context information to a monitor of the CSL or a function of exchanging data with a networking stack of the CSL. 13. The terminal apparatus according to claim 12, wherein the RA is distributed in a form of a radio application package (RAP) comprising at least one of: the SFBs; the UDFBs; the radio controller code; and a pipeline configuration meta data defining relations among the SFBs, the UDFBs, and the radio controller code. 14. The terminal apparatus according to claim 13, wherein the RAP further comprises a radio library including the SFBs. 15. A method of executing a radio application (RA), performed in a terminal apparatus including an application processor (AP) and a radio processor (RP), the method comprising: providing at least one of an administrative service, an access control service, and a data flow service for the RA in a communication service layer operating on the AP or the RP; providing operation environments for the RA by interworking with the CSL in a radio control framework (RCF) operating on both of the AP and the RP or on the RP; and providing a multi radio interface (MURI) for interworking of the CSL and the RCF. 16. A multi radio subsystem providing a multi radio interface (MURI) operating in a terminal apparatus executing a radio application (RA), wherein the MURI provides functions for interworking of a communication service layer (CSL) operating on an application processor (AP) or a radio processor (RP) and a radio control framework (RCF) operating on the AP or the RP, wherein the CSL provides at least one of an administrative service, an access control service, and a data flow service of the RA for the RA, and wherein the RCF provides operating environments for the RA by interworking with the CSL. 17. The multi radio subsystem according to claim 16, wherein the multi radio subsystem provides at least one of: an administrative service performing management of the RA, an access control service controlling activation/deactivation of the RA; and a data flow service providing a function of transferring user data of the terminal apparatus or user data received at the terminal apparatus. 18. The multi radio subsystem according to claim 17, wherein the administrative service transfers at least one of a request of installation or uninstallation of the RA, a request of creating or deleting an instance of the RA, a request of list information of RAs, and a request of status information of RAs from an administrator of the CSL to the RCF. 19. The multi radio subsystem according to claim 18, wherein the administrative service controls a configuration manager of the RCF to perform installation or uninstallation of the RA and creation or deletion of an instance of the RA based on the request, and transfers confirmation for the installation, uninstallation, creation, or deletion from the configuration manager to the administrator. 20. The multi radio subsystem according to claim 17, wherein the access control service transfers at least one of a request of list information of RAs, a request of measurements for radio environments, a request of measurements for the terminal apparatus capabilities, a request of creating a data flow, and a request of network and logical radio link association from the CSL to the RCF such that a mobility policy manager (MPM) of the CSL monitors capabilities and radio environments of the terminal apparatus and selects at least one of one or more radio access technologies (RATs)."
14786092,"A polymeric material, in particular a polymeric material manufactured by polymerisation or polyaddition, for example polyolefins or polyurethanes, in particular polyethylene, with an antimicrobial surface. The polymeric material contains a maximum of 0.1% by weight of fatty acid ester, a maximum of 0.1% by weight of superacid counter-ions and between 2.5% by weight and a maximum of 10% by weight, preferably a maximum of 5% by weight, of at least one compound (1) which brings about the antimicrobial action. This compound (1) consists of at least one antimicrobially effective hydrophilic molecular group (2) and at least one molecular group (4) which causes physical anchoring of the compound (1) in the polymeric material (3).","1-13. (canceled) 14. Plastic material, made in particular by polymerization or polyaddition plastics, for example, polyolefins or polyurethanes, in particular polyethylene, marked with an antimicrobial surface, characterized in that the plastic material more than 0.1 weight-% fatty acid ester, a maximum of 0.1 weight-% superacid counterion and between 2.5 weight -% and at most 10 weight-%, preferably at most 5 weight-%, at least one of the antimicrobial effect of causing the compound (1), consisting of at least one antimicrobially active hydrophilic molecular group (2) and at least one of a physical anchorage of the compound (1) in the plastic material (3) effecting molecular group (4). 15. Plastic material according to claim 14, characterized in that the compound (1) is selected at least one compound from the substance group of quaternary ammonium compounds with non-functional and/or non-reactive terminal groups with antimicrobial activity. 16. plastic material according to claim 14, characterized in that has been selected as a compound having antimicrobial activity, at least one compound from the substance group of compounds with at least one anti-adhesive active molecule group, preferably from the group of substances of perfluorocarbons or silicones 17. Plastic material according to claim 14, characterized in that at least one anti-adhesive effective additively covalently to a compound (1) is attached from the substance group of quaternary ammonium compounds. 18. The plastic material according to claim 14, characterized in that at least one of the anchoring of the compound (1) with antimicrobial activity effecting molecular groups (4) a high affinity to the base material (3) of the plastic material. 19. Plastic material according to claim 18, characterized in that the compound (1) with antimicrobial activity comprising at least a preferably unbranched, long-chain hydrocarbon radical (4). 20. plastic material according to claim 15, characterized in that the compound (1) with antimicrobial activity, a quaternary ammonium compound having at least two, preferably three hydrocarbon groups (4). 21. Plastic material according to claim 19, characterized in that the elongated molecular chain or long-chain hydrocarbon group (4) is or contains at least one C17-alkyl. 22. Plastic material according to claim 14, characterized in that the antimicrobially effective molecular group (2) or the anti-adhesive active molecule group of the compound (1) with anti-microbial or anti-adhesive effect protrudes over the surface of the plastic material (3) and at least one other molecular group (4) of the compound (1) in the base material (3) of the plastic material is anchored. 23. Plastic material according to claim 14, characterized in that at least one compound having antimicrobial activity is a bifunctional, bridged quaternary ammonium compound (1a), having two quaternary ammonium groups, (2), which by a common substituent (4a) are bridged. 24. Plastic material according to claim 14, characterized in that at least one compound with antimicrobial activity is a quaternary ammonium compound, which additionally comprises an anti-adhesive active molecule group bridging with the quaternary ammonium compound through a common substituents is. 25. Plastic material according to claim 23, characterized in that the substituent (4a) has at least a long chain molecule (8) of the base material (3) of the plastic material surrounds and is anchored so that the plastic material (3), wherein at least one, preferably both quaternary ammonium compounds (2) or both of the quaternary ammonium compound and the anti-adhesive active molecule group on the surface of the plastic material (3) protrude. 26. A process for the manufacture of a plastic material, in particular by polymerization or polyaddition, for example a polyolefin or polyurethane, in particular polyethylene, with antimicrobial surface, characterized in that a plastic melt of a base material is a mixture as in claim 14 admixed, that is, a mixture with a maximum of 0.1 weight-% fatty acid ester, a maximum of 0.1 weight-% superacid counterions and between 2.5 weight-% and at most 10 weight-%, preferably at most 5 weight-%, based on the weight of the plastic melt, at least one antimicrobial and/or anti-adhesive effect inducing compound which compound is composed of at least one anti-microbial or anti-adhesively active molecule group and at least one physical anchoring of the compound in the plastic material causing molecular group, and then the mixture of molten plastic and the mixture compounded and compounded mixture is then extruded."
14888152,"A roll for a machine for producing and/or processing a fibrous web, such as a paper, board or tissue web, has a circular-cylindrical main roll body. A roll cover covers the circumferential surface of the main roll body, at least in some segments. A pressure- and/or temperature-sensitive sensor is embedded in the roll cover. The sensor connects to an electrical and/or optical signal line. The signal line has a first line segment inside the roll. A second line segment extends substantially outside the roll and is connectable to a signal excitation and/or signal processing unit at one end. An electrical and/or optical rotational connection connects the first and second line segments to allow the line segments to be rotated relative to one another. When the roll is rotated, the first line segment rotates together with the main roll body. The second line segment does not have to follow the rotation.","1-17. (canceled) 18. A roll for a machine for producing and/or processing a fibrous web, the roll comprising: a circular-cylindrical main roll body having a circumferential surface, a longitudinal axis and two axial ends; bearing journals arranged at said two axial ends of said main roll body for rotatably supporting said roll body about said longitudinal axis on a frame of the machine; a roll cover covering said circumferential surface of said main roll body at least in some segments thereof; at least one sensor selected from the group consisting of pressure sensors and temperature sensors; an electrical and/or optical signal line for signal exchange with a signal excitation and/or signal processing unit, said signal line including a first line segment extending substantially in an interior of said roll and having an end connected to said at least one sensor, a second line segment extending substantially outside said roll and having an end connectable to the signal excitation and/or signal processing unit; and an electrical and/or optical rotational connection for connecting said first and second line segments to one another and to allow said first and second line segments to rotate relative to one another so that, when the roll is rotated about said longitudinal axis, said first line segment rotates together with said main roll body, whereas said second line segment does not have to follow the rotational movement. 19. The roll according to claim 18, wherein said second line segment is detachably or non-detachably connected to said rotational connection. 20. The roll according to claim 18, wherein said rotational connection comprises a first connecting piece and a second connecting piece, said first and second connection pieces are mounted for rotation relative to one another about an axis of rotation, wherein said first line segment is connected or connectable to said first connecting piece at an end opposite said sensor, and said second line segment is connected or connectable to said second connecting piece at an end thereof opposite the end that is connected or connectable to the excitation and/or signal processing unit. 21. The roll according to claim 18, wherein said rotational connection is arranged on a free front end of bearing journal. 22. The roll according to claim 18, wherein said rotational connection is arranged on the roll such that an axis of rotation of said first and second connecting pieces coincides with the axis of rotation of the roll. 23. The roll according to claim 18, wherein said at least one sensor is a piezoelectric sensor and said signal line is an electrical line, and wherein said rotational connection is an electric rotary connector. 24. The roll according to claim 23, wherein said electric rotary connector is a slip-ring transmitter. 25. The roll according to claim 18, wherein said at least one sensor is an optical sensor, said signal line is an optical fiber, and said rotational connection is an optical rotary connector. 26. The roll according to claim 25, wherein said at least one sensor is a fiber Bragg sensor and said optical rotary connector is a fiber-optic rotary connector. 27. The roll according to claim 25, wherein said first line segment is connected at one end to at least one sensor segment which includes a plurality of fiber-optic sensors arranged one after another in series. 28. The roll according to claim 27, wherein said at least one sensor segment is one of a plurality of sensor segments. 29. The roll according to claim 18, wherein said first line segment of said signal line extends substantially in said roll cover and/or in an interior of said circular-cylindrical main roll body. 30. The roll according to claim 18, wherein said roll has a diameter of less than 850 mm. 31. The roll according to claim 30, wherein said roll has a diameter in a range from 100 mm to 800 mm. 32. A machine for producing and/or processing a fibrous web, the machine comprising: a roll according to claim 18 mounted for rotation about the longitudinal axis thereof; a signal excitation and/or signal processing unit connected to said roll via said signal line, wherein said signal excitation and/or signal processing unit is not arranged on said roll and does not rotate with said roll during a rotation of said roll about the longitudinal axis thereof. 33. The machine according to claim 32, wherein said signal excitation and/or signal processing unit is a mobile signal generating and/or signal processing unit that is detachably connectable to said second line segment. 34. The machine according to claim 32, wherein said signal excitation unit comprises a light source and/or said signal processing unit comprises a light receiver. 35. The machine according to claim 34, wherein said signal excitation unit comprises a spectrometer with polychromator and/or a data computer. 36. The machine according to claim 32, wherein said roll is disposed to form a nip together with an opposing roll, and wherein a pressure and/or a temperature is measured in the nip. 37. A method for measuring a pressure and/or a temperature, the method comprising: providing a roll according to claim 18; connecting a mobile signal excitation and/or signal processing unit to the second line segment and carrying out a measurement with the mobile signal excitation and/or signal processing unit connected to the second line segment; and after the measurement has been carried out, separating the mobile signal excitation and/or signal processing unit from the second line segment."
14888288,"Provided are composite materials that possesses an excellent flexural modulus and impact resistance, while being lightweight, and which composite material has excellent impact resistance particularly at low temperatures.","1. A composite material comprising a composite material comprising a matrix resin, and glass fibers and glass bubbles dispersed in the matrix resin; at least 70% of the glass fibers having a fiber length of 1.0 mm or greater, and a median diameter of the glass bubbles being at least 10 μm and not more than 40 μm. 2. The composite material according to claim 1, having a content of the glass bubbles CB and a content of the glass fibers CF, wherein a mass ratio CB/CF of is at least 0.1 and not more than 10. 3. The composite material according to claim 1, wherein a content of the glass fibers is at least 1% by mass and not more than 40% by mass based on a total quantity of the composite material. 4. The composite material according to claim 1, wherein a content of the glass bubbles is at least 1% by mass and not more than 30% by mass based on a total quantity of the composite material. 5. The composite material according to claim 1, wherein a 90%-volume residual compressive strength of the glass bubbles is at least 50 MPa. 6. The composite material according to claim 1, wherein a true density of the glass bubbles is at least 0.3 g/cm3, and less than 0.9 g/cm3. 7. The composite material according to claim 1, wherein the composite material is obtained by melt-kneading resin pellets, in which fiber bundles of glass fibers are impregnated with a base resin, and a resin material containing glass bubbles. 8. The composite material according to claim 7, wherein a melt-kneaded product of the resin pellets and the resin material is obtained by extrusion molding. 9. (canceled) 10. (canceled)"
14889989,"An object of the present invention is to provide a curable epoxy resin composition, which is cured to provide a cured product having a high glass-transition temperature and particularly having excellent balance between heat resistance and transparency. The present invention relates to a curable epoxy resin composition comprising an alicyclic epoxy compound (A) represented by the following formula (1) and a curing agent (B). The curable epoxy resin composition further preferably comprises a curing accelerator (C). wherein R1 to R22, which may be the same or different, each represent a hydrogen atom, a methyl group or an ethyl group.","1. A curable epoxy resin composition comprising an alicyclic epoxy compound (A) represented by the following formula (1): wherein R1 to R22, which may be the same or different, each represent a hydrogen atom, a methyl group or an ethyl group, and a curing agent (B). 2. The curable epoxy resin composition according to claim 1, further comprising a curing accelerator (C). 3. A cured product obtained by curing the curable epoxy resin composition according to claim 1. 4. A cured product obtained by curing the curable epoxy resin composition according to claim 2."
14890445,"This invention relates to methods for preparation of chemical compound 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4a8,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid, which comprise addition of heterocyclic amine containing protecting group, to ethyl-3-oxo-3-(2,4,5-trifluoro-3-methoxyphenyl)propanoate, followed by interaction with triethyl orthoformate, addition of cyclic amine, subsequent cyclization and formation of target product. The method for preparation claimed is technologically simple in comparison with analogue and requires no special complex technical operations, which in its turn simplifies method for preparation of this chemical compound, and reduces cost of the final product, while the commercial production utilizing the mehod claimed has low degree of environmental threat.","1. A method for preparation of a compound of formula (6) comprising the steps of: a) introducing tert-butyloctahydro-1H-pyrrolo[3,4b]pyridine-1-carboxylate into the compound of formula (1) to form a compound of formula (2) b) interacting the compound of formula (2) with triethyl orthoformate in acetic anhydride to form a compound of formula (3) c) adding cyclic amine to the compound of formula (3) to form a compound of formula (4) d) cyclizing of the compound of formula (4) in alkaline conditions to form the compound of formula (5) and e) cleaving Boc protecting groups from the compound of formula (5) to form a final compound of formula (6) 2. The method according to claim 1, characterized in that step a) is conducted in the presence of a base. 3. The method according to claim 1, characterized in that step b) is conducted in acetic anhydride at 130° C. 4. The method according to claim 1, characterized in that step c) is conducted at room temperature. 5. The method according to claim 1, characterized in that step d) is conducted in the presence of 3N potassium hydroxide at 50° C."
14891188,"Disclosed are a NFC antenna module which maximizes antenna performance by mounting a radiation sheet in such a manner as to partially overlap with an antenna sheet and a portable terminal comprising the same. The disclosed NFC antenna module comprises: an electromagnetic wave shielding sheet; an antenna sheet laminated on the electromagnetic wave shielding sheet and having a radiation pattern formed along the outer periphery of a central portion thereof; and a radiation sheet laminated on the antenna sheet so as to form an overlapping area with the radiation pattern and having a recess formed therein, through which the central portion is exposed.","1. A Near-Field Communication (NFC) antenna module, comprising: an electromagnetic shielding sheet; an antenna sheet in which a radiation pattern is formed along a peripheral surface of a central part, the antenna sheet being stacked on the electromagnetic shielding sheet; and a radiation sheet stacked on the antenna sheet to form an area that overlaps the radiation pattern, the radiation sheet having a depression formed to expose the central part. 2. The NFC antenna module of claim 1, wherein the radiation sheet forms an area that overlaps a left pattern, a right pattern, and a lower pattern of the radiation pattern. 3. The NFC antenna module of claim 1, wherein the radiation sheet comprises: a first protrusion formed on a left side of the depression and configured to form an area that overlaps a left pattern of the radiation pattern; a second protrusion formed on a right side of the depression and configured to form an area that overlaps a right pattern of the radiation pattern; and a base element formed under the depression and configured to form an area that overlaps a lower pattern of the radiation pattern. 4. The NFC antenna module of claim 3, wherein the base element is configured such that one or more slots for exposing part of the lower pattern are formed in the area that overlaps the lower pattern. 5. The NFC antenna module of claim 3, wherein the radiation sheet comprises: a first radiation sheet comprising the first protrusion and part of the base element, and forming an area that overlaps the left pattern and the lower pattern of the radiation pattern; and a second radiation sheet comprising the second protrusion and remaining part of the base element, and forming an area that overlaps the right pattern and the lower pattern of the radiation pattern. 6. The NFC antenna module of claim 5, wherein the first radiation sheet and the second radiation sheet are spaced apart from each other by a separation space in the area that overlaps the lower pattern, and the lower pattern of the radiation pattern is exposed to outside through the separation space. 7. The NFC antenna module of claim 1, wherein the radiation sheet comprises: a first protrusion formed on a left side of the depression and configured to form an area that overlaps a left pattern of the radiation pattern; a second protrusion formed on a right side of the depression and configured to form an area that overlaps a right pattern of the radiation pattern; and a base element formed under the depression, and configured to expose a lower pattern of the radiation pattern. 8. The NFC antenna module of claim 7, wherein the radiation sheet comprises: a first radiation sheet comprising the first protrusion and part of the base element, and forming an area that overlaps the left pattern of the radiation pattern; and a second radiation sheet comprising the second protrusion and remaining part of the base element, and forming an area that overlaps the right pattern of the radiation pattern, wherein the first and second radiation sheets are spaced apart from each other. 9. The NFC antenna module of claim 1, wherein the electromagnetic shielding sheet comprises a ferrite sheet. 10. A portable terminal comprising the NFC antenna module of claim 1. 11. The portable terminal of claim 10, wherein the NFC antenna module is mounted on a battery pack or a rear housing of the portable terminal."
14891201,Disclosed are a NFC antenna module which maximizes antenna performance by mounting a radiation sheet in such a manner as to overlap a part of an antenna sheet and a portable terminal comprising the same. The disclosed NFC antenna module comprises: a first antenna sheet having a first radiation pattern formed along the outer periphery of a first central portion; a second antenna sheet having a second radiation pattern formed along the outer periphery of a second central portion in such a manner as to partially overlap with the first radiation pattern; and an electromagnetic wave shielding sheet laminated on the first antenna sheet and the second antenna sheet.,"1. A Near-Field Communication (NFC) antenna module, comprising: a first antenna sheet provided with a first radiation pattern formed along a peripheral surface of a first central part; a second antenna sheet provided with a second radiation pattern formed along a peripheral surface of a second central part, the second radiation pattern being formed to partially overlap the first radiation pattern; and an electromagnetic shielding sheet stacked on both the first antenna sheet and the second antenna sheet. 2. The NFC antenna module of claim 1, wherein the second radiation pattern comprises a lower pattern forming an area that overlaps a lower pattern of the first radiation pattern. 3. The NFC antenna module of claim 1, further comprising a tuning element connected between both ends of the second radiation pattern. 4. The NFC antenna module of claim 1, further comprising a radiation sheet stacked both on the first antenna sheet and on the second antenna sheet and provided with a portion that overlaps the first radiation pattern and the second radiation pattern. 5. The NFC antenna module of claim 4, wherein the radiation sheet forms an area that overlaps a left pattern and a right pattern of the first radiation pattern, and forms an area that overlaps a left pattern, a right pattern, and an upper pattern of the second radiation pattern. 6. The NFC antenna module of claim 4, wherein the radiation sheet comprises: a first protrusion for forming an area that overlaps a left pattern of the first radiation pattern and a right pattern of the second radiation pattern; a second protrusion for forming an area that overlaps a right pattern of the first radiation pattern and a left pattern of the second radiation pattern; and a base element for forming an area that overlaps an upper pattern of the second radiation pattern. 7. The NFC antenna module of claim 6, wherein the base element is configured such that one or more slots, exposing part of the upper pattern of the second radiation pattern, are formed in the area that overlaps the upper pattern. 8. The NFC antenna module of claim 6, wherein the radiation sheet comprises: a first radiation sheet comprising the first protrusion and part of the base element, first radiation sheet forming an area that overlaps the left pattern of the first radiation pattern and forming an area that overlaps the right pattern and the upper pattern of the second radiation pattern; and a second radiation sheet comprising the second protrusion and remaining part of the base element, the second radiation sheet forming an area that overlaps the right pattern of the first radiation pattern and forming an area that overlaps the left pattern and the upper pattern of the second radiation pattern. 9. The NFC antenna module of claim 8, wherein the first radiation sheet and the second radiation sheet are spaced apart from each other by a separation space in the area that overlaps the upper pattern of the second radiation pattern, and are configured to expose the upper pattern of the second radiation pattern to outside through the separation space. 10. The NFC antenna module of claim 1, wherein the electromagnetic shielding sheet comprises a ferrite sheet. 11. A portable terminal comprising the NFC antenna module of claim 1. 12. The portable terminal of claim 11, wherein the NFC antenna module is mounted on a battery pack or a rear housing of the portable terminal."