id
int64 0
3.49M
| contents
stringlengths 8
8.5k
| source
stringclasses 3
values |
|---|---|---|
100 | Reaction information for COc1ccc2c(c1)c(-c1cc3c(ncc4cncn43)[nH]1)cn2C
{'reactant': 'COc1ccc2c(c1)c(-c1cc3c(ncc4cncn43)n1COCC[Si](C)(C)C)cn2C', 'reagent': 'CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.NCCN.[F-]', 'product': 'COc1ccc2c(c1)c(-c1cc3c(ncc4cncn43)[nH]1)cn2C', 'yield': '80.2%'} | uspto |
101 | Reaction information for Cn1c(C(F)(F)F)cc(=O)n(C)c1=O
{'reactant': 'CI.Cn1c(=O)cc(C(F)(F)F)[nH]c1=O', 'reagent': 'COCCOC.O.O=C([O-])[O-].[K+].[K+]', 'product': 'Cn1c(C(F)(F)F)cc(=O)n(C)c1=O', 'yield': '82.9%'} | uspto |
102 | Reaction information for CCCCCCCC(=O)N(C)Cc1cc(-c2ccc(CCC(=O)O)cc2)cs1
{'reactant': 'CCCCCCCC(=O)N(C)Cc1cc(-c2ccc(CCC(=O)OCC)cc2)cs1', 'reagent': 'C1CCOC1.CC(=O)O.CO.O.[Na+].[OH-]', 'product': 'CCCCCCCC(=O)N(C)Cc1cc(-c2ccc(CCC(=O)O)cc2)cs1', 'yield': '37.0%'} | uspto |
103 | Reaction information for C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)[C@H]1CC[C@@H](Nc2cc(OCCN3CCCCC3)ncc2N)CC1
{'reactant': 'C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)[C@H]1CC[C@@H](Nc2cc(OCCN3CCCCC3)ncc2[N+](=O)[O-])CC1', 'reagent': 'CCOC(C)=O.CO.Cl[Sn]Cl', 'product': 'C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)[C@H]1CC[C@@H](Nc2cc(OCCN3CCCCC3)ncc2N)CC1', 'yield': '100.0%'} | uspto |
104 | Reaction information for O=[N+]([O-])c1cccc2c1cnn2Cc1ccc(F)cc1F
{'reactant': 'Fc1ccc(CBr)c(F)c1.O=[N+]([O-])c1cccc2[nH]ncc12', 'reagent': 'CC(C)=O.[K+].[OH-]', 'product': 'O=[N+]([O-])c1cccc2c1cnn2Cc1ccc(F)cc1F', 'yield': '40.0%'} | uspto |
105 | Reaction information for OCc1cc(O)cc(Br)c1
{'reactant': 'O=C(O)c1cc(O)cc(Br)c1', 'reagent': 'C1CCOC1.Cl.[Al+3].[H-].[H-].[H-].[H-].[Li+]', 'product': 'OCc1cc(O)cc(Br)c1', 'yield': '35.9%'} | uspto |
106 | Reaction information for CC(=O)NC(C)(C)CNc1c(C)c(C)nc(Cl)c1[N+](=O)[O-]
{'reactant': 'CC(=O)OC(C)=O.Cc1nc(Cl)c([N+](=O)[O-])c(NCC(C)(C)N)c1C', 'reagent': 'CCN(CC)CC.ClCCl', 'product': 'CC(=O)NC(C)(C)CNc1c(C)c(C)nc(Cl)c1[N+](=O)[O-]', 'yield': '83.1%'} | uspto |
107 | Reaction information for CCN(c1ccc(C(=O)O)cc1)c1cc(C)c2c(c1)C(C)(C)CO2
{'reactant': 'CCOC(=O)c1ccc(N(CC)c2cc(C)c3c(c2)C(C)(C)CO3)cc1', 'reagent': 'CCO.[K+].[OH-]', 'product': 'CCN(c1ccc(C(=O)O)cc1)c1cc(C)c2c(c1)C(C)(C)CO2', 'yield': '7.5%'} | uspto |
108 | Reaction information for CC(C)c1cc(Oc2c(Cl)cc(CC3SC(=O)NC3=O)cc2Cl)ccc1O
{'reactant': 'COc1ccc(Oc2c(Cl)cc(CC3SC(=O)NC3=O)cc2Cl)cc1C(C)C', 'reagent': 'BrB(Br)Br.ClCCl', 'product': 'CC(C)c1cc(Oc2c(Cl)cc(CC3SC(=O)NC3=O)cc2Cl)ccc1O', 'yield': '76.8%'} | uspto |
109 | Reaction information for O=C(O)C1CCC(c2noc(=O)[nH]2)CC1
{'reactant': 'COC(=O)C1CCC(c2noc(=O)[nH]2)CC1', 'reagent': 'C1CCOC1.[Li+].[OH-]', 'product': 'O=C(O)C1CCC(c2noc(=O)[nH]2)CC1', 'yield': '19.6%'} | uspto |
110 | Reaction information for OCc1ccc(Oc2ccccc2)c2ccccc12
{'reactant': 'O=Cc1ccc(Oc2ccccc2)c2ccccc12', 'reagent': 'CCO.[BH4-].[Na+]', 'product': 'OCc1ccc(Oc2ccccc2)c2ccccc12', 'yield': '97.5%'} | uspto |
111 | Reaction information for COc1cc2nc(N3CCC(Nc4ccc(C(=O)OC(C)(C)C)cc4)CC3)nc(Nc3ccc(C)cc3)c2cc1OC
{'reactant': 'CC(C)(C)OC(=O)c1ccc(NC2CCNCC2)cc1.COc1cc2nc(Cl)nc(Nc3ccc(C)cc3)c2cc1OC', 'reagent': 'CCCCCO', 'product': 'COc1cc2nc(N3CCC(Nc4ccc(C(=O)OC(C)(C)C)cc4)CC3)nc(Nc3ccc(C)cc3)c2cc1OC', 'yield': '85.4%'} | uspto |
112 | Reaction information for CCN(Cc1ccccc1F)C(=O)CCc1ccc(OCc2ccccc2C(=O)O)cc1
{'reactant': 'CCN(Cc1ccccc1F)C(=O)CCc1ccc(OCc2ccccc2C(=O)OC)cc1', 'reagent': 'CCO.[K+].[OH-]', 'product': 'CCN(Cc1ccccc1F)C(=O)CCc1ccc(OCc2ccccc2C(=O)O)cc1', 'yield': '18.0%'} | uspto |
113 | Reaction information for CNC(=O)C1CCN(CCCOc2ccc(-n3nc4ccccc4c3Cl)cc2)CC1
{'reactant': 'CN.O=C(O)C1CCN(CCCOc2ccc(-n3nc4ccccc4c3Cl)cc2)CC1', 'reagent': 'Cl.ClCCl.O=C(Cl)C(=O)Cl', 'product': 'CNC(=O)C1CCN(CCCOc2ccc(-n3nc4ccccc4c3Cl)cc2)CC1', 'yield': '96.4%'} | uspto |
114 | Reaction information for COC(=O)c1cc(N)c(N2CCCCC2)c(S(C)(=O)=O)c1
{'reactant': 'COC(=O)c1cc([N+](=O)[O-])c(N2CCCCC2)c(S(C)(=O)=O)c1', 'reagent': 'C.C1CCOC1.CO.[Pd]', 'product': 'COC(=O)c1cc(N)c(N2CCCCC2)c(S(C)(=O)=O)c1', 'yield': '95.5%'} | uspto |
115 | Reaction information for CC1(C)CC(=O)c2cc(OS(=O)(=O)C(F)(F)F)c(F)cc2S1
{'reactant': 'CC1(C)CC(=O)c2cc(O)c(F)cc2S1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F', 'reagent': 'c1ccncc1', 'product': 'CC1(C)CC(=O)c2cc(OS(=O)(=O)C(F)(F)F)c(F)cc2S1', 'yield': '72.2%'} | uspto |
116 | Reaction information for COc1ccc(CC(=O)Nc2c(C)c(C)c3oc(C)c(-c4ccc(C(C)C)cc4)c3c2C)cc1
{'reactant': 'COc1ccc(CC(=O)Cl)cc1.Cc1oc2c(C)c(C)c(N)c(C)c2c1-c1ccc(C(C)C)cc1', 'reagent': 'CO', 'product': 'COc1ccc(CC(=O)Nc2c(C)c(C)c3oc(C)c(-c4ccc(C(C)C)cc4)c3c2C)cc1', 'yield': '42.0%'} | uspto |
117 | Reaction information for COC(=O)c1ccc(CC(C(=O)Nc2ccc(I)cc2)c2ccc(O)cc2)cc1
{'reactant': 'COC(=O)c1ccc(CC(C(=O)O)c2ccc(O)cc2)cc1.Nc1ccc(I)cc1', 'reagent': 'ClCCl.O=C(Cl)C(=O)Cl', 'product': 'COC(=O)c1ccc(CC(C(=O)Nc2ccc(I)cc2)c2ccc(O)cc2)cc1', 'yield': '63.9%'} | uspto |
118 | Reaction information for CC(=O)c1ccc(OCc2cncnc2)cc1OC(CCC(=O)O)c1ccccc1C
{'reactant': 'CCOC(=O)CCC(Oc1cc(OCc2cncnc2)ccc1C(C)=O)c1ccccc1C', 'reagent': 'C1COCCO1.[Na+].[OH-]', 'product': 'CC(=O)c1ccc(OCc2cncnc2)cc1OC(CCC(=O)O)c1ccccc1C', 'yield': '42.7%'} | uspto |
119 | Reaction information for COc1cc(OC2CNC2)ccc1CN1CCOCC1
{'reactant': 'COc1cc(OC2CN(C(=O)OC(C)(C)C)C2)ccc1CN1CCOCC1', 'reagent': 'ClCCl.O=C(O)C(F)(F)F', 'product': 'COc1cc(OC2CNC2)ccc1CN1CCOCC1', 'yield': '65.9%'} | uspto |
120 | Reaction information for COC(=O)CC(C)C(=O)Cl
{'reactant': 'COC(=O)CC(C)C(=O)O.O=C(Cl)C(=O)Cl', 'reagent': 'CN(C)C=O.ClCCl', 'product': 'COC(=O)CC(C)C(=O)Cl', 'yield': '96.0%'} | uspto |
121 | Reaction information for COc1ccc(-c2n[nH]c3nc(NC(C)=O)sc23)cc1
{'reactant': 'CC(=O)Cl.COc1ccc(-c2n[nH]c3nc(N)sc23)cc1', 'reagent': 'C1CCOC1.CN(C)c1ccncc1.NC(CO)(CO)CO', 'product': 'COc1ccc(-c2n[nH]c3nc(NC(C)=O)sc23)cc1', 'yield': '14.1%'} | uspto |
122 | Reaction information for O=[N+]([O-])c1cc(Br)c2nc(CF)[nH]c2c1
{'reactant': 'Nc1cc([N+](=O)[O-])cc(Br)c1N.O=C(O)CF', 'reagent': 'Cc1ccccc1', 'product': 'O=[N+]([O-])c1cc(Br)c2nc(CF)[nH]c2c1', 'yield': '75.2%'} | uspto |
123 | Reaction information for CCOc1ncc(S(=O)(=O)N2CCN(CC)CC2)cc1Br
{'reactant': 'CCN1CCN(S(=O)(=O)c2cnc(Cl)c(Br)c2)CC1.CCO', 'reagent': 'CC[O-].[Na+]', 'product': 'CCOc1ncc(S(=O)(=O)N2CCN(CC)CC2)cc1Br', 'yield': '94.9%'} | uspto |
124 | Reaction information for CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)N[C@@H]2C(=O)N3C(C(=S)OC(c4ccccc4)c4ccccc4)=C(CSc4c[nH]nn4)CS[C@H]23)cs1
{'reactant': 'CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)O)cs1.N[C@@H]1C(=O)N2C(C(=S)OC(c3ccccc3)c3ccccc3)=C(CSc3c[nH]nn3)CS[C@H]12', 'reagent': 'CN1CCOCC1.Cl.Cl.ClCCl.O=P(Cl)(Cl)Oc1ccccc1', 'product': 'CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)N[C@@H]2C(=O)N3C(C(=S)OC(c4ccccc4)c4ccccc4)=C(CSc4c[nH]nn4)CS[C@H]23)cs1', 'yield': '54.6%'} | uspto |
125 | Reaction information for CCN(CC)C(=O)c1cc2ccsc2c(-c2ccccc2Cl)n1
{'reactant': 'CCNCC.O=C(O)c1cc2ccsc2c(-c2ccccc2Cl)n1', 'reagent': 'CCN(CC)CC.CCOC(=O)Cl.ClC(Cl)Cl', 'product': 'CCN(CC)C(=O)c1cc2ccsc2c(-c2ccccc2Cl)n1', 'yield': '40.6%'} | uspto |
126 | Reaction information for O=C(NCC(=O)N1CCN(C(=O)c2ccc(Cl)cc2Cl)CC1)c1ccc(Oc2ccccc2)cc1
{'reactant': 'O=C(NCC(=O)N1CCNCC1)c1ccc(Oc2ccccc2)cc1.O=C(O)c1ccc(Cl)cc1Cl', 'reagent': 'CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.On1nnc2ccccc21', 'product': 'O=C(NCC(=O)N1CCN(C(=O)c2ccc(Cl)cc2Cl)CC1)c1ccc(Oc2ccccc2)cc1', 'yield': '64.0%'} | uspto |
127 | Reaction information for C=CCC(CC=C)(COc1cc(C)c(-c2ccc(C(F)(F)F)cc2)c(C)c1)c1ccc(C(=O)NCCC(=O)OC)cc1
{'reactant': 'C=CCC(CC=C)(COc1cc(C)c(-c2ccc(C(F)(F)F)cc2)c(C)c1)c1ccc(C(=O)O)cc1.COC(=O)CCN', 'reagent': 'CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.O.O.On1nnc2ccccc21', 'product': 'C=CCC(CC=C)(COc1cc(C)c(-c2ccc(C(F)(F)F)cc2)c(C)c1)c1ccc(C(=O)NCCC(=O)OC)cc1', 'yield': '72.2%'} | uspto |
128 | Reaction information for CN1CCC(CN(C)c2nc3cc(NC(=O)c4ccc(-c5ccc(Cl)cc5Cl)cc4)ccc3o2)C1
{'reactant': 'CN1CCC(CN(C)c2nc3cc(N)ccc3o2)C1.O=C(O)c1ccc(-c2ccc(Cl)cc2Cl)cc1', 'reagent': 'CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F', 'product': 'CN1CCC(CN(C)c2nc3cc(NC(=O)c4ccc(-c5ccc(Cl)cc5Cl)cc4)ccc3o2)C1', 'yield': '45.9%'} | uspto |
129 | Reaction information for COn1c(=O)c(-c2cc(N)ccc2Cl)cc2cnc(NCCN(C)C)nc21
{'reactant': 'COn1c(=O)c(-c2cc([N+](=O)[O-])ccc2Cl)cc2cnc(NCCN(C)C)nc21', 'reagent': 'CCO.Cl.[Fe]', 'product': 'COn1c(=O)c(-c2cc(N)ccc2Cl)cc2cnc(NCCN(C)C)nc21', 'yield': '32.0%'} | uspto |
130 | Reaction information for COC(=O)/C=C/c1ccc(OCCCCCCCCCl)c(OC)c1
{'reactant': 'COC(=O)/C=C/c1ccc(O)c(OC)c1.OCCCCCCCCCl', 'reagent': 'C1CCOC1.CCOC(=O)N=NC(=O)OCC.Cc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1', 'product': 'COC(=O)/C=C/c1ccc(OCCCCCCCCCl)c(OC)c1', 'yield': '90.2%'} | uspto |
131 | Reaction information for Cc1cccc(C(=O)Nc2ccc(Sc3nc(Nc4cc(C)n[nH]4)cc(N4CCC4)n3)cc2)c1
{'reactant': 'Cc1cc(Nc2cc(N3CCC3)nc(Sc3ccc(N)cc3)n2)[nH]n1.Cc1cccc(C(=O)Cl)c1', 'reagent': 'c1ccncc1', 'product': 'Cc1cccc(C(=O)Nc2ccc(Sc3nc(Nc4cc(C)n[nH]4)cc(N4CCC4)n3)cc2)c1', 'yield': '33.1%'} | uspto |
132 | Reaction information for CCc1cn([C@H]2C[C@H](O)[C@@H](CNC(=O)Cc3ccccc3Br)O2)c(=O)nc1NC(=O)c1ccccc1
{'reactant': 'CCc1cn([C@H]2C[C@H](O)[C@@H](CN)O2)c(=O)nc1NC(=O)c1ccccc1.O=C(Cl)Cc1ccccc1Br', 'reagent': 'CCOCC.[Na+].[OH-]', 'product': 'CCc1cn([C@H]2C[C@H](O)[C@@H](CNC(=O)Cc3ccccc3Br)O2)c(=O)nc1NC(=O)c1ccccc1', 'yield': '20.0%'} | uspto |
133 | Reaction information for NC(=O)Cc1c(-c2ccccc2)nn(-c2ccccc2)c1-c1ccccc1
{'reactant': 'N.O=C(O)Cc1c(-c2ccccc2)nn(-c2ccccc2)c1-c1ccccc1', 'reagent': 'CCOC(C)=O.O.O=P(Cl)(Cl)Cl.c1ccccc1', 'product': 'NC(=O)Cc1c(-c2ccccc2)nn(-c2ccccc2)c1-c1ccccc1', 'yield': '91.0%'} | uspto |
134 | Reaction information for N#Cc1ccc(C(=O)N2CCN(c3cccc4c3CCC(=O)N4)CC2)cc1
{'reactant': 'N#Cc1ccc(C(=O)Cl)cc1.O=C1CCc2c(cccc2N2CCNCC2)N1', 'reagent': 'CN(C)C.CN(C)C=O.O', 'product': 'N#Cc1ccc(C(=O)N2CCN(c3cccc4c3CCC(=O)N4)CC2)cc1', 'yield': '46.9%'} | uspto |
135 | Reaction information for CN(C)c1ccccc1CC(=O)N1CC2C(=O)CCC(c3cccc(F)c3)(c3cccc(F)c3)C2C1
{'reactant': 'CN(C)c1ccccc1CC(=O)O.O=C1CCC(c2cccc(F)c2)(c2cccc(F)c2)C2CNCC12', 'reagent': 'CCN(CC)CC.Cl.ClCCl', 'product': 'CN(C)c1ccccc1CC(=O)N1CC2C(=O)CCC(c3cccc(F)c3)(c3cccc(F)c3)C2C1', 'yield': '34.4%'} | uspto |
136 | Reaction information for Nc1ccc(N2C(=O)c3ccccc3C2=O)cc1
{'reactant': 'O=C1c2ccccc2C(=O)N1c1ccc([N+](=O)[O-])cc1', 'reagent': 'N.O.O=[V](=O)O.[H][H].[O-2].[O-2].[Pd].[Ti+4]', 'product': 'Nc1ccc(N2C(=O)c3ccccc3C2=O)cc1', 'yield': '79.8%'} | uspto |
137 | Reaction information for O=C(Cc1ccc2c(c1)OCO2)Nc1cc(F)cc(F)c1C(=O)O
{'reactant': 'Nc1cc(F)cc(F)c1C(=O)O.O=C(Cl)Cc1ccc2c(c1)OCO2', 'reagent': 'ClCCl.c1ccncc1', 'product': 'O=C(Cc1ccc2c(c1)OCO2)Nc1cc(F)cc(F)c1C(=O)O', 'yield': '79.8%'} | uspto |
138 | Reaction information for Cc1nc(-c2ccc(C(F)(F)F)cc2)ncc1CN(C)c1ccc2c(ccn2CC(=O)O)c1
{'reactant': 'COC(=O)Cn1ccc2cc(N(C)Cc3cnc(-c4ccc(C(F)(F)F)cc4)nc3C)ccc21', 'reagent': 'C1CCOC1.CCOC(C)=O.Cl.[Li+].[OH-]', 'product': 'Cc1nc(-c2ccc(C(F)(F)F)cc2)ncc1CN(C)c1ccc2c(ccn2CC(=O)O)c1', 'yield': '68.9%'} | uspto |
139 | Reaction information for Nc1ccc2c(c1)-c1[nH]ncc1CS2
{'reactant': 'O=[N+]([O-])c1ccc2c(c1)-c1[nH]ncc1CS2', 'reagent': 'CCO.O.[Cl-].[Fe].[NH4+]', 'product': 'Nc1ccc2c(c1)-c1[nH]ncc1CS2', 'yield': '65.9%'} | uspto |
140 | Reaction information for O=C(O)C=Cc1ccc(C(F)(F)F)nc1Sc1ccccc1
{'reactant': 'COC(=O)C=Cc1ccc(C(F)(F)F)nc1Sc1ccccc1', 'reagent': '[Li+].[OH-]', 'product': 'O=C(O)C=Cc1ccc(C(F)(F)F)nc1Sc1ccccc1', 'yield': '82.1%'} | uspto |
141 | Reaction information for O=c1c(Br)cc(-c2ccccn2)cn1-c1ccccc1
{'reactant': 'O=C1CCC(=O)N1Br.O=c1ccc(-c2ccccn2)cn1-c1ccccc1', 'reagent': 'CN(C)C=O.O.O=C1CCC(=O)N1Br', 'product': 'O=c1c(Br)cc(-c2ccccn2)cn1-c1ccccc1', 'yield': '79.4%'} | uspto |
142 | Reaction information for Cn1c(=O)c2c(nc(C3CCCC(N)C3)n2Cc2ccccc2)c2ccccc21
{'reactant': 'Cn1c(=O)c2c(nc(C3CCCC(NC(=O)OCc4ccccc4)C3)n2Cc2ccccc2)c2ccccc21', 'reagent': '[Pd]', 'product': 'Cn1c(=O)c2c(nc(C3CCCC(N)C3)n2Cc2ccccc2)c2ccccc21', 'yield': '86.6%'} | uspto |
143 | Reaction information for CN1CCC(c2nn(-c3cnc4[nH]cc(C(=O)NC(C)(C)CO)c4n3)c3ccccc23)CC1
{'reactant': 'CN1CCC(c2nn(-c3cnc4c(n3)c(C(=O)NC(C)(C)CO)cn4COCC[Si](C)(C)C)c3ccccc23)CC1', 'reagent': 'ClCCl.O=C(O)C(F)(F)F', 'product': 'CN1CCC(c2nn(-c3cnc4[nH]cc(C(=O)NC(C)(C)CO)c4n3)c3ccccc23)CC1', 'yield': '22.8%'} | uspto |
144 | Reaction information for CC(C)N(CC(N)=O)C(=O)c1csc(N2CC(O)C2)n1
{'reactant': 'CC(C)N(CC(N)=O)C(=O)c1csc(N2CC(O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)C2)n1', 'reagent': 'C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]', 'product': 'CC(C)N(CC(N)=O)C(=O)c1csc(N2CC(O)C2)n1', 'yield': '66.9%'} | uspto |
145 | Reaction information for O=C(O)Cc1ccc(NC(=O)c2c(Cl)ccc(OCc3cccc(Cl)c3)c2F)cc1
{'reactant': 'CCOC(=O)Cc1ccc(NC(=O)c2c(Cl)ccc(OCc3cccc(Cl)c3)c2F)cc1', 'reagent': 'C1COCCO1.O.[Li+].[OH-]', 'product': 'O=C(O)Cc1ccc(NC(=O)c2c(Cl)ccc(OCc3cccc(Cl)c3)c2F)cc1', 'yield': '32.0%'} | uspto |
146 | Reaction information for CC1(C)c2cc(N3CCC(N4CCOCC4)CC3)ncc2C(=O)c2c1[nH]c1cc(C#N)ccc21
{'reactant': 'CC1(C)c2cc(N3CCC(N4CCOCC4)CC3)ncc2C(=O)c2c1[nH]c1cc(C(N)=O)ccc21', 'reagent': 'CN(C)C=O.O.O=S(Cl)Cl', 'product': 'CC1(C)c2cc(N3CCC(N4CCOCC4)CC3)ncc2C(=O)c2c1[nH]c1cc(C#N)ccc21', 'yield': '48.6%'} | uspto |
147 | Reaction information for CCCN(C1CCCC1)[C@H]1COc2c(F)ccc(OC)c2C1
{'reactant': 'CCC=O.COc1ccc(F)c2c1C[C@@H](NC1CCCC1)CO2', 'reagent': 'CO.[BH3-]C#N.[Na+]', 'product': 'CCCN(C1CCCC1)[C@H]1COc2c(F)ccc(OC)c2C1', 'yield': '97.0%'} | uspto |
148 | Reaction information for O=[N+]([O-])c1ccc(SC2CC2)cc1
{'reactant': 'O=[N+]([O-])c1ccc(F)cc1.SC1CC1', 'reagent': 'C1CCOC1.CCOCC.O.[H-].[Na+]', 'product': 'O=[N+]([O-])c1ccc(SC2CC2)cc1', 'yield': '61.0%'} | uspto |
149 | Reaction information for CCCCCCCC=O
{'reactant': 'CCCCCCCCO', 'reagent': 'C=Cc1ccc(SC)cc1.CCN(CC)CC.CCOCC.ClCCl.ClCl', 'product': 'CCCCCCCC=O', 'yield': '95.1%'} | uspto |
150 | Reaction information for CCCCN(Cc1ccc(Cl)c(Cl)c1)C(=O)c1nn(-c2ccc(C(=O)O)cc2C(=O)N2CCc3ccccc3C2)c(C)c1Cl
{'reactant': 'CCCCN(Cc1ccc(Cl)c(Cl)c1)C(=O)c1nn(-c2ccc(C(=O)OCc3ccccc3)cc2C(=O)N2CCc3ccccc3C2)c(C)c1Cl', 'reagent': 'CCCCN(CCCC)C(=O)c1nn(-c2ccc(C(=O)O)cc2C(=O)N2CCc3ccccc3C2)c(C)c1Br', 'product': 'CCCCN(Cc1ccc(Cl)c(Cl)c1)C(=O)c1nn(-c2ccc(C(=O)O)cc2C(=O)N2CCc3ccccc3C2)c(C)c1Cl', 'yield': '98.1%'} | uspto |
151 | Reaction information for CCOC(=O)c1ccn(C)c1C
{'reactant': 'CCOC(=O)c1cc[nH]c1C.CI', 'reagent': 'CN(C)C=O.[H-].[Na+]', 'product': 'CCOC(=O)c1ccn(C)c1C', 'yield': '42.2%'} | uspto |
152 | Reaction information for CC1(C)CC(OC(=O)CCl)CC(C)(C)N1OC1CCCCC1
{'reactant': 'CC1(C)CC(O)CC(C)(C)N1OC1CCCCC1.O=C(Cl)CCl', 'reagent': 'CCN(CC)CC.CCOCC.ClCCl', 'product': 'CC1(C)CC(OC(=O)CCl)CC(C)(C)N1OC1CCCCC1', 'yield': '38.8%'} | uspto |
153 | Reaction information for CC(C)(C)OC(=O)COC1CCC(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)CC1
{'reactant': 'CC(C)(C)OC(=O)COC1CCC(N)CC1.O=S(=O)(c1ccc(Br)cc1)C(F)(F)F', 'reagent': 'CC(=O)[O-].CC(=O)[O-].Cc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1', 'product': 'CC(C)(C)OC(=O)COC1CCC(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)CC1', 'yield': '98.2%'} | uspto |
154 | Reaction information for CCCN(CCC)C(=O)c1cc(Cl)ccn1
{'reactant': 'CCCNCCC.O=C(O)c1cc(Cl)ccn1', 'reagent': 'CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.On1nnc2ccccc21', 'product': 'CCCN(CCC)C(=O)c1cc(Cl)ccn1', 'yield': '67.1%'} | uspto |
155 | Reaction information for CC(C)(N)CNc1c([N+](=O)[O-])cnc2cc(OCc3ccccc3)ccc12
{'reactant': 'CC(C)(N)CN.O=[N+]([O-])c1cnc2cc(OCc3ccccc3)ccc2c1Cl', 'reagent': 'CC(C)CN', 'product': 'CC(C)(N)CNc1c([N+](=O)[O-])cnc2cc(OCc3ccccc3)ccc12', 'yield': '73.6%'} | uspto |
156 | Reaction information for COCCN(CCc1cccc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)c1)C(=O)OC(C)(C)C
{'reactant': 'COCCN(CCc1cccc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)c1)C(=O)OC(C)(C)C', 'reagent': 'CO.O.[Cl-].[NH4+].[Zn]', 'product': 'COCCN(CCc1cccc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)c1)C(=O)OC(C)(C)C', 'yield': '86.9%'} | uspto |
157 | Reaction information for COc1ccc(F)cc1C(C)(C)CC(O)(CNc1cc(C)cc2c1cnn2-c1cccc(C(=O)N(C)[C@@H](C)C(N)=O)c1)C(F)(F)F
{'reactant': 'COc1ccc(F)cc1C(C)(C)CC(O)(CNc1cc(C)cc2c1cnn2-c1cccc(C(=O)N(C)[C@@H](C)C(=O)O)c1)C(F)(F)F.N', 'reagent': 'C1COCCO1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CO.F[P-](F)(F)(F)(F)F', 'product': 'COc1ccc(F)cc1C(C)(C)CC(O)(CNc1cc(C)cc2c1cnn2-c1cccc(C(=O)N(C)[C@@H](C)C(N)=O)c1)C(F)(F)F', 'yield': '34.2%'} | uspto |
158 | Reaction information for Cc1cc(C(F)(F)F)c(C2(c3ccsc3)C=C(OCCCCCCC(C)C(Oc3ccccc3CCC(=O)O)C(=O)O)C=C(c3ccc4c(c3)OCO4)C2)c(=O)n1C
{'reactant': 'CCOC(=O)CCc1ccccc1OC(C(=O)OCC)C(C)CCCCCCOC1=CC(c2ccsc2)(c2c(C(F)(F)F)cc(C)n(C)c2=O)CC(c2ccc3c(c2)OCO3)=C1', 'reagent': '[Na+].[OH-]', 'product': 'Cc1cc(C(F)(F)F)c(C2(c3ccsc3)C=C(OCCCCCCC(C)C(Oc3ccccc3CCC(=O)O)C(=O)O)C=C(c3ccc4c(c3)OCO4)C2)c(=O)n1C', 'yield': '83.5%'} | uspto |
159 | Reaction information for O=[N+]([O-])c1cnc(Nc2ccc(F)cc2)c(Br)c1
{'reactant': 'Nc1ccc(F)cc1.O=[N+]([O-])c1cnc(Cl)c(Br)c1', 'reagent': 'CS(C)=O', 'product': 'O=[N+]([O-])c1cnc(Nc2ccc(F)cc2)c(Br)c1', 'yield': '81.1%'} | uspto |
160 | Reaction information for CC(C)(C)[Si]1(C(C)(C)C)OCC(CBr)CO1
{'reactant': 'BrC(Br)(Br)Br.CC(C)(C)[Si]1(C(C)(C)C)OCC(CO)CO1', 'reagent': 'ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccncc1', 'product': 'CC(C)(C)[Si]1(C(C)(C)C)OCC(CBr)CO1', 'yield': '84.1%'} | uspto |
161 | Reaction information for COc1cccc(CBr)c1Br
{'reactant': 'COc1cccc(C)c1Br.O=C1CCC(=O)N1Br', 'reagent': 'ClC(Cl)(Cl)Cl', 'product': 'COc1cccc(CBr)c1Br', 'yield': '58.0%'} | uspto |
162 | Reaction information for CC(OC(=O)CCl)C1CCCC(C)(C)C1
{'reactant': 'CC(O)C1CCCC(C)(C)C1.O=C(O)CCl', 'reagent': 'C(=NC1CCCCC1)=NC1CCCCC1.CN(C)c1ccncc1.ClCCl', 'product': 'CC(OC(=O)CCl)C1CCCC(C)(C)C1', 'yield': '88.0%'} | uspto |
163 | Reaction information for CS(=O)(=O)c1ccc([C@@H](CC2CCC(=O)C2)C(=O)Nc2cnccn2)cc1Cl
{'reactant': 'CS(=O)(=O)c1ccc([C@@H](CC2CCC(O)C2)C(=O)Nc2cnccn2)cc1Cl', 'reagent': 'CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl', 'product': 'CS(=O)(=O)c1ccc([C@@H](CC2CCC(=O)C2)C(=O)Nc2cnccn2)cc1Cl', 'yield': '75.0%'} | uspto |
164 | Reaction information for O=C(O)Cn1c(C(=O)c2ccccc2)ccc1-c1ccccc1
{'reactant': 'CC(C)(C)OC(=O)Cn1c(C(=O)c2ccccc2)ccc1-c1ccccc1', 'reagent': 'O=C(O)C(F)(F)F', 'product': 'O=C(O)Cn1c(C(=O)c2ccccc2)ccc1-c1ccccc1', 'yield': '100.0%'} | uspto |
165 | Reaction information for Nc1ccc(Oc2ccnc(NC(=O)N3CCOCC3)c2)cc1
{'reactant': 'O=C(Nc1cc(Oc2ccc([N+](=O)[O-])cc2)ccn1)N1CCOCC1', 'reagent': 'C1CCOC1.CCCCCC.CCO.CCOC(C)=O.CCOCC.O.[Cl-].[Fe].[NH4+]', 'product': 'Nc1ccc(Oc2ccnc(NC(=O)N3CCOCC3)c2)cc1', 'yield': '39.2%'} | uspto |
166 | Reaction information for C[C@H](Nc1cc2c(cc1C(N)=O)ncn2-c1cc(C2CC2)[nH]n1)c1ccc(F)cc1
{'reactant': 'C[C@H](Nc1cc2c(cc1C#N)ncn2-c1cc(C2CC2)[nH]n1)c1ccc(F)cc1.OO', 'reagent': 'CO.O.[K+].[OH-]', 'product': 'C[C@H](Nc1cc2c(cc1C(N)=O)ncn2-c1cc(C2CC2)[nH]n1)c1ccc(F)cc1', 'yield': '44.0%'} | uspto |
167 | Reaction information for O=C(c1ccc(Br)cc1)C1CCNCC1
{'reactant': 'O=C(c1ccc(Br)cc1)C1CCN(C(=O)C(F)(F)F)CC1', 'reagent': 'CO.O.O=C([O-])[O-].[K+].[K+]', 'product': 'O=C(c1ccc(Br)cc1)C1CCNCC1', 'yield': '93.6%'} | uspto |
168 | Reaction information for Cc1cc2c(cc1OS(=O)(=O)C(F)(F)F)N(Cc1ccccc1)C(=O)C2(C)C
{'reactant': 'Cc1cc2c(cc1O)N(Cc1ccccc1)C(=O)C2(C)C.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F', 'reagent': 'ClCCl.c1ccncc1', 'product': 'Cc1cc2c(cc1OS(=O)(=O)C(F)(F)F)N(Cc1ccccc1)C(=O)C2(C)C', 'yield': '95.2%'} | uspto |
169 | Reaction information for COc1ccc(F)c(-c2ncc(COc3cccc(C(CC(=O)O)C4CC4)c3)cc2OCC(C)C)c1
{'reactant': 'COC(=O)CC(c1cccc(OCc2cnc(-c3cc(OC)ccc3F)c(OCC(C)C)c2)c1)C1CC1', 'reagent': 'C1CCOC1.CO.Cl.[Na+].[OH-]', 'product': 'COc1ccc(F)c(-c2ncc(COc3cccc(C(CC(=O)O)C4CC4)c3)cc2OCC(C)C)c1', 'yield': '88.8%'} | uspto |
170 | Reaction information for O=C(O)c1cccnc1Nc1cc(-c2ccc(F)cc2)nn1-c1ccccc1Cl
{'reactant': 'CCOC(=O)c1cccnc1Nc1cc(-c2ccc(F)cc2)nn1-c1ccccc1Cl', 'reagent': 'C1CCOC1.CCO.Cl.O.O.[Li+].[OH-]', 'product': 'O=C(O)c1cccnc1Nc1cc(-c2ccc(F)cc2)nn1-c1ccccc1Cl', 'yield': '99.0%'} | uspto |
171 | Reaction information for Cc1cc(CO)ccc1Cl
{'reactant': 'COC(=O)c1ccc(Cl)c(C)c1', 'reagent': 'CC(C)C[Al+]CC(C)C.ClCCl.[H-]', 'product': 'Cc1cc(CO)ccc1Cl', 'yield': '79.3%'} | uspto |
172 | Reaction information for NC(=O)c1cccc2c1c1c(OCC(=O)O)cccc1n2Cc1ccccc1Cc1ccccc1
{'reactant': 'COC(=O)COc1cccc2c1c1c(C(N)=O)cccc1n2Cc1ccccc1Cc1ccccc1', 'reagent': 'CCO.[Na+].[OH-]', 'product': 'NC(=O)c1cccc2c1c1c(OCC(=O)O)cccc1n2Cc1ccccc1Cc1ccccc1', 'yield': '45.2%'} | uspto |
173 | Reaction information for COC(=O)Cc1ccc2c(c1)CCS2
{'reactant': 'CO.O=C(O)Cc1ccc2c(c1)CCS2', 'reagent': 'Cl', 'product': 'COC(=O)Cc1ccc2c(c1)CCS2', 'yield': '94.0%'} | uspto |
174 | Reaction information for CC(C)(C)OC(=O)N(Cc1ccccc1)C1CN(C(c2ccccc2)c2ccccc2)C1
{'reactant': 'CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.c1ccc(CNC2CN(C(c3ccccc3)c3ccccc3)C2)cc1', 'reagent': 'ClCCl.O=C([O-])[O-].[Na+].[Na+]', 'product': 'CC(C)(C)OC(=O)N(Cc1ccccc1)C1CN(C(c2ccccc2)c2ccccc2)C1', 'yield': '95.3%'} | uspto |
175 | Reaction information for Nc1nc(N2CCN(S(=O)(=O)c3ccccc3)CC2)c2nc(-c3ccc(F)cc3)sc2n1
{'reactant': 'Nc1nc(N2CCNCC2)c2nc(-c3ccc(F)cc3)sc2n1.O=S(=O)(Cl)c1ccccc1', 'reagent': 'CN(C)C=O.c1ccncc1', 'product': 'Nc1nc(N2CCN(S(=O)(=O)c3ccccc3)CC2)c2nc(-c3ccc(F)cc3)sc2n1', 'yield': '45.2%'} | uspto |
176 | Reaction information for CCCCc1nc2cc(-c3ccccc3)c(C=O)nc2n1Cc1ccc(-c2ccccc2-c2nnnn2C(C)OCC)cc1
{'reactant': 'CCCCc1nc2cc(-c3ccccc3)c(CO)nc2n1Cc1ccc(-c2ccccc2-c2nnnn2C(C)OCC)cc1', 'reagent': 'ClCCl.O=[Mn]=O', 'product': 'CCCCc1nc2cc(-c3ccccc3)c(C=O)nc2n1Cc1ccc(-c2ccccc2-c2nnnn2C(C)OCC)cc1', 'yield': '87.9%'} | uspto |
177 | Reaction information for COCC(=O)NCc1ccc(C(=O)Nc2nc3c(OC)ccc(N4CCOCC4)c3s2)cc1
{'reactant': 'COCC(=O)Cl.COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccc(CN)cc3)nc12', 'reagent': 'ClCCl.O=C([O-])[O-].[Na+].[Na+].c1ccncc1', 'product': 'COCC(=O)NCc1ccc(C(=O)Nc2nc3c(OC)ccc(N4CCOCC4)c3s2)cc1', 'yield': '71.0%'} | uspto |
178 | Reaction information for O=C(O)CCCCNC(=O)NCCCCC1CCSS1
{'reactant': 'COC(=O)CCCCNC(=O)NCCCCC1CCSS1', 'reagent': 'CO.[Na+].[OH-]', 'product': 'O=C(O)CCCCNC(=O)NCCCCC1CCSS1', 'yield': '80.0%'} | uspto |
179 | Reaction information for O=C(Cc1ccccc1)NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1
{'reactant': 'NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1.O=C(O)Cc1ccccc1', 'reagent': 'CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.O=C(O)C(F)(F)F.On1nnc2ccccc21', 'product': 'O=C(Cc1ccccc1)NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1', 'yield': '43.4%'} | uspto |
180 | Reaction information for CC1(C)OB(c2ccc(N3CCCC3)c(C#N)c2)OC1(C)C
{'reactant': 'C1CCNC1.CC1(C)OB(c2ccc(F)c(C#N)c2)OC1(C)C', 'reagent': 'CN1CCCC1=O', 'product': 'CC1(C)OB(c2ccc(N3CCCC3)c(C#N)c2)OC1(C)C', 'yield': '63.0%'} | uspto |
181 | Reaction information for O=Cc1ccc(N2CCCCC2)cc1
{'reactant': 'CN(C)C=O.c1ccc(N2CCCCC2)cc1', 'reagent': 'ClCCCl.O=P(Cl)(Cl)Cl', 'product': 'O=Cc1ccc(N2CCCCC2)cc1', 'yield': '40.0%'} | uspto |
182 | Reaction information for C[C@@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cc(F)cc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)nc1
{'reactant': 'CC(=O)OCc1c(-c2cc(Nc3ccc(N4CCN(C5COC5)C[C@H]4C)cn3)c(=O)n(C)c2)cc(F)cc1N1CCn2c(cc3c2CC(C)(C)C3)C1=O', 'reagent': 'C1CCOC1.CC(C)O.O.[Li+].[OH-]', 'product': 'C[C@@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cc(F)cc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)nc1', 'yield': '78.9%'} | uspto |
183 | Reaction information for Cc1cc(Cl)c(C(=O)O)cc1I
{'reactant': 'Cc1ccc(C(=O)O)c(Cl)c1.O=C1CCC(=O)N1I', 'reagent': 'ClCCl.O=S(=O)(O)C(F)(F)F', 'product': 'Cc1cc(Cl)c(C(=O)O)cc1I', 'yield': '57.2%'} | uspto |
184 | Reaction information for C#Cc1ccc(C(CC2CCCC2)C(=O)Nc2nccs2)cc1
{'reactant': 'C#Cc1ccc(C(CC2CCCC2)C(=O)O)cc1.Nc1nccs1', 'reagent': 'CCN(CC)CC.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.ClCCl.F[P-](F)(F)(F)(F)F', 'product': 'C#Cc1ccc(C(CC2CCCC2)C(=O)Nc2nccs2)cc1', 'yield': '56.8%'} | uspto |
185 | Reaction information for CCn1cc(C(=O)O)c(=O)c2cc(Cl)c(N3CCN(c4ccccc4)CC3)cc21
{'reactant': 'CCn1cc(C(=O)O)c(=O)c2cc(Cl)c(Cl)cc21.c1ccc(N2CCNCC2)cc1', 'reagent': 'CC(=O)O.c1ccncc1', 'product': 'CCn1cc(C(=O)O)c(=O)c2cc(Cl)c(N3CCN(c4ccccc4)CC3)cc21', 'yield': '54.9%'} | uspto |
186 | Reaction information for O=C(O)Cn1[nH]c(=O)c2cc([N+](=O)[O-])ccc21
{'reactant': 'CCOC(=O)Cn1[nH]c(=O)c2cc([N+](=O)[O-])ccc21', 'reagent': 'C1CCOC1.CCOC(C)=O.Cl.[Na+].[OH-]', 'product': 'O=C(O)Cn1[nH]c(=O)c2cc([N+](=O)[O-])ccc21', 'yield': '68.0%'} | uspto |
187 | Reaction information for CC(=NOCc1cc(C(F)(F)F)ccc1C(F)(F)F)c1cc(Cl)ccc1NS(=O)(=O)C(F)(F)F
{'reactant': 'CC(=O)c1cc(Cl)ccc1NS(=O)(=O)C(F)(F)F.NOCc1cc(C(F)(F)F)ccc1C(F)(F)F', 'reagent': 'CC(=O)O.CC(=O)[O-].CO.Cl.O.[Na+]', 'product': 'CC(=NOCc1cc(C(F)(F)F)ccc1C(F)(F)F)c1cc(Cl)ccc1NS(=O)(=O)C(F)(F)F', 'yield': '18.8%'} | uspto |
188 | Reaction information for Nc1cccc2c1c(C1CC1)nn2Cc1ccccc1
{'reactant': 'O=[N+]([O-])c1cccc2c1c(C1CC1)nn2Cc1ccccc1', 'reagent': 'CCO.O.[Cl-].[Fe].[NH4+]', 'product': 'Nc1cccc2c1c(C1CC1)nn2Cc1ccccc1', 'yield': '66.7%'} | uspto |
189 | Reaction information for O=C(O)CC(Cc1nc(CCCCCNc2ccccn2)co1)c1ccccc1
{'reactant': 'CCOC(=O)CC(Cc1nc(CCCCCNc2ccccn2)co1)c1ccccc1', 'reagent': 'C1CCOC1.Cl.O.[Li+].[OH-]', 'product': 'O=C(O)CC(Cc1nc(CCCCCNc2ccccn2)co1)c1ccccc1', 'yield': '60.9%'} | uspto |
190 | Reaction information for CCOC(=O)C1CCN(c2ccc(C(C)C(O)(c3ccc4c(c3)N(C)C(=O)CO4)C(F)(F)F)c(Cl)c2)CC1
{'reactant': 'CC(c1ccc(Br)cc1Cl)C(O)(c1ccc2c(c1)N(C)C(=O)CO2)C(F)(F)F.CCOC(=O)C1CCNCC1', 'reagent': 'CCOC(C)=O.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1', 'product': 'CCOC(=O)C1CCN(c2ccc(C(C)C(O)(c3ccc4c(c3)N(C)C(=O)CO4)C(F)(F)F)c(Cl)c2)CC1', 'yield': '3.2%'} | uspto |
191 | Reaction information for O=C(c1ccc(OCCN2CCCCCC2)cc1)c1c(-c2c(F)cc(F)cc2F)ccc2cc(O)ccc12
{'reactant': 'COc1ccc2c(C(=O)c3ccc(OCCN4CCCCCC4)cc3)c(-c3c(F)cc(F)cc3F)ccc2c1', 'reagent': 'BrB(Br)Br.CO.Cl.ClCCl.O=C([O-])O.[Na+]', 'product': 'O=C(c1ccc(OCCN2CCCCCC2)cc1)c1c(-c2c(F)cc(F)cc2F)ccc2cc(O)ccc12', 'yield': '56.6%'} | uspto |
192 | Reaction information for CON(C)C(=O)c1cccc(Br)c1Cl
{'reactant': 'CNOC.O=C(O)c1cccc(Br)c1Cl', 'reagent': 'C1CCOC1.CCN=C=NCCCN(C)C.Cl.Cl.c1ccncc1', 'product': 'CON(C)C(=O)c1cccc(Br)c1Cl', 'yield': '84.5%'} | uspto |
193 | Reaction information for CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCOCC(=O)O
{'reactant': 'CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCOCC(=O)OC', 'reagent': 'C1CCOC1.CO.Cl.O.[Li+].[OH-]', 'product': 'CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCOCC(=O)O', 'yield': '20.5%'} | uspto |
194 | Reaction information for N#CCc1ccc(Cc2ccccc2OCc2ccccc2)cc1
{'reactant': 'ClCc1ccc(Cc2ccccc2OCc2ccccc2)cc1.[C-]#N', 'reagent': 'CN(C)C=O.O.[K+]', 'product': 'N#CCc1ccc(Cc2ccccc2OCc2ccccc2)cc1', 'yield': '84.3%'} | uspto |
195 | Reaction information for O=C(NCc1c[nH]c(=S)n1[C@H]1CCc2c(F)cc(F)cc2C1)c1ccccn1
{'reactant': 'NCc1c[nH]c(=S)n1[C@H]1CCc2c(F)cc(F)cc2C1.O=C(O)c1ccccn1', 'reagent': 'CCN(C(C)C)C(C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1', 'product': 'O=C(NCc1c[nH]c(=S)n1[C@H]1CCc2c(F)cc(F)cc2C1)c1ccccn1', 'yield': '20.0%'} | uspto |
196 | Reaction information for NCc1cccc(N2CC[C@@H](O)C2)c1
{'reactant': 'N#Cc1cccc(N2CC[C@@H](O)C2)c1', 'reagent': 'CCO.[NH4+].[OH-].[Rh]', 'product': 'NCc1cccc(N2CC[C@@H](O)C2)c1', 'yield': '69.0%'} | uspto |
197 | Reaction information for O=C(N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)O)c1cc(Br)ccc1OCc1ccccc1
{'reactant': 'COC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1cc(Br)ccc1OCc1ccccc1', 'reagent': 'C1CCOC1.CO.[Li+].[OH-]', 'product': 'O=C(N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)O)c1cc(Br)ccc1OCc1ccccc1', 'yield': '69.7%'} | uspto |
198 | Reaction information for CCCc1ccc(OS(=O)(=O)c2ccc(C)cc2)c(OC)c1
{'reactant': 'CCCc1ccc(O)c(OC)c1.Cc1ccc(S(=O)(=O)Cl)cc1', 'reagent': 'CC#N.O=C([O-])[O-].[I-].[K+].[K+].[Na+]', 'product': 'CCCc1ccc(OS(=O)(=O)c2ccc(C)cc2)c(OC)c1', 'yield': '66.0%'} | uspto |
199 | Reaction information for COCC(C)(C)NC(=O)C(F)(F)C(O)(Cn1cncn1)c1ccc(F)cc1F
{'reactant': 'CC(C)(CO)NC(=O)C(F)(F)C(O)(Cn1cncn1)c1ccc(F)cc1F.CI', 'reagent': 'CCOC(C)=O.CN(C)C=O.Cl.O.[H-].[Na+]', 'product': 'COCC(C)(C)NC(=O)C(F)(F)C(O)(Cn1cncn1)c1ccc(F)cc1F', 'yield': '29.0%'} | uspto |
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