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dissection of microglial state biology in brain repair | microglia the macrophages of the brain are critical regulators of many neurobiological functions and implicated by human genetics in several central nervous system diseases recent studies have revealed that microglia can adopt distinct coexisting subtypes termed states microglial states appear especially in the context of damage disease or repair and understanding these states may lead to the ability to precisely modulate neuroinflammation however due to a lack of datasets and tools the dynamics and functions of these microglial states are unknown representing a poorly explored frontier of neurosciencethe core goal of this proposal is to understand the kinetics and biological roles of microglial states using focal brain repair in the mouse as a model system i will address this knowledge gap with three synergistic objectives first how do microglial states change in space and time to answer this i will unravel the dynamics of microglial states by generating a spatiotemporal atlas of gene expression at the singlecell level from injury to full repair second how do specific microglial states emerge and what are their functions i will address this question by focusing on one state that interacts with the peripheral immune system and appears to be triggered by a particular cytokine finally i will build novel molecular tools to genetically access and specifically arrest any microglial state this will enable me to investigate their impact on remyelination and uncover the biological mechanisms by which microglial states orchestrate brain repair together this work will comprehensively dissect the biology of microglial states in brain repair and provide the enabling technologies to do the same in other contexts from development to disease it will open up microglial states to experimentation resulting in a step change in our understanding of this important brain cell type |
ontologybased decentralized sharing of industry data in the european circular economy | circular economy aims at reducing value loss and avoiding waste by circulating materials or product parts before they become waste today lack of support for sharing data in a secure quality assured and automated way is one of the main obstacles that industry actors point to when creating new circular value networks together with using different terminologies and not having explicit definitions of the concepts that appear in data this makes it very difficult to create new ecosystems of actors in europe today this project will address the core challenges of making decentralized data and information understandable and usable for humans as well as machines the project will leverage open standards for semantic data interoperability in establishing a shared vocabulary ontology network for data documentation as well as a decentralized digital platform that enables collaboration in a secure and privacypreserving manner the project addresses a number of open research problems including the development of ontologies that need to model a wide range of different materials and products not only providing vertical interoperability but also horizontal interoperability for crossindustry value networks as well as transdisciplinary research on methods to find analyse and assess new circular value chain configurations opened up by considering resource information value and energy flows as an integral part of the same complex system three industry use cases from radically different industry domains act as drivers for the research and development activities as well as test beds and demonstrators for the crossindustry applicability of the results the developed solutions will allow for automation of planning management and execution of circular value networks at a european scale and beyond the project thereby supports acceleration of the digital and green transitions automating the discovery and formation of new collaborations in the circular economy |
european facility on molten salt technologies to power and energy system applications | the use of thermal energy storage tes in combination with the thermal conversion of solar irradiation concentrated solar power csp has long been regarded as an important technological solution for the production of dispatchable electricity whereas thermal oil based systems have set the standard in the first generation of commercial csp plants the use of molten salts as heat transfer and storage media has been gathering research efforts and is regarded by the industry as the foregoing standard for new commercial plantsmolten salt ms research has been deployed along the past decade in germany and italy alongside with the erection of dedicated research infrastructure ri enabling the study and experimental test of eg materials components or om procedures suiting this innovative technological approach with the recent commissioning of a fullfledged molten salt solar system emulating a commercial mscsp plant in vora portugal has joined this research effort with a new outstanding ri in this fieldgathering the unique experience of two nonwidening partners in the development and operation of the most important msri at european level with the incumbent new ri capacity available in a widening country the present proposal aims at enhancing the scientific excellence and innovation capacity of the consortium in the foregoing exploitation of this outstanding ri saltopower has a strong focus on an enhanced capacity building of researchers going beyond purely scientific capacities strengthening the research management and administration skills of the widening riby means of enhanced cooperation duly framed on a common research strategy aiming at further developing ms technologies saltopower aims at creating the reference european facility for the development and testing of molten salt based technologies for energy storage and dispatchable power production solutions for the integration of different renewable energy sources power and gas grids |
the development of a full scale plant for the production of sustainable medium chain fatty acids | to meet the valuechainwide need for a viable circular economic model that facilitates the achievement of the eus sustainabilitygoals chaincraft has developed an economicallyviable process that converts organic residues into valuable biobased mediumchain fatty acids mcfa for the agrifood and material industries our unique and patented solution is based on a threestepprocess using open culture fermentation and downstream processing to create mixed mcfa and their downstream fractionatedpure products we take organic residues from municipalities supermarkets and food production industries and convert them intomcfa these mcfa are supplied to industries producing ao animal feed food herbicides plasticizers and detergents in returnsome of these companies supply industries of which their waste stream will again be used as feedstock in our process making ittruly circularour next target in making the chemical industry more sustainable is the construction of a full scale plant using our circular technology the first milestone in achieving this target is the final investment decision fid to reach this milestone we need the are several major steps with significant challenges we need to make a contract for feedstock and location validate our product with our potential customers arrange agreements with these customers and then design our plant based on this acquired knowledge as these steps involve significant risk the support of eic is key in achieving our target and will help us making the necessary steps to execute our sustainable plan |
a learningfromprices view of inflation and business cycles | the eurozone is currently facing a sudden and sharp increase in inflation whether inflationary pressures will persist and what will be the cost of an eventual monetary tightening crucially depends on inflation expectations the aim of this project is to provide theoretical and empirical support to a new channel through which inflation may persistently shift business activity the project sheds new light on how market prices influence consumers perceived inflation and how this may allow for the transmission of monetary policy even in the absence of rigidities in firms pricing it shifts the focus from a traditional firmcentric to a complementary householdcentric view of money nonneutrality it shares the spirit of a recent trend in central banks efforts in getting a better appraisal of the importance of consumers expectations after decades of a strict empirical focus on firms pricing the project consists of five working packages wp based on the idea that households inflation perceptions driven by actual market prices can be a major source of the business cycle the first wp proposes a new theory where outputinflation comovement relies on consumers price hunting in response to perceived inflation causing a countercyclical gap between posted and paid prices inflation the second and third wp aim at validating the mechanism using large datasets on consumers spending and retail trade the fourth presents a new model where consumers learn from inflation about future economic prospects on which all have dispersed foresight the fifth will estimate this model on survey data the key novelty of the project is studying not only how expectations move market outcomes as typical in the literature but also how these feedback to expectations through prices in a full circle of general equilibrium implications as byproduct it identifies measurable empirical counterparts for incomplete information sets |
space architecture design and prototyping in planetary analogue environments | in this decade we aim to come back to the moon to stay it is therefore crucial to develop reliable and safe settlements that adequately protect astronauts physical and mental wellbeing from all possible threats that the hostile environment of extraterrestrial space presents archispace aims to design and build subsystems prototypes eg walls roofs living spaces etc of human infrastructures to be built on planetary surfaces which will be tested in planetary analogue environments this project represents the first effort to the best of our knowledge to use environmental and geological setting analogues as a base to define architectural constraints sketch design and prototypes to be used in future space human settlements archispace is pioneering a new fields of interdisciplinary and intersectoral research in europe by bridging geologyspace sciences and architecturespace architecture geologyspace science is crucial because the subsurface plays a fundamental role in the selection of the landing sites and the location of humanfocused habitats architecturespace architecture has a key role in designing comfortable safe and functional habitats our complementary partners are leaders in their respective sectors and hold the necessary knowhow andor technology level to achieve the archispace objectives in addition the human settlements to be developed will involve new low impact lowcost and light operations and isru materials this planetary green approach could also be applied on earth the project will create through the planned secondments common standards methods and prototypes for the development of space bases on moon and mars in the future which will be tested in three joint field activities eg in morocco analogues sites thus archispace promotes an innovative international intersectoral and interdisciplinary research and innovation collaboration that can contribute to europes competitiveness and growth |
from chrysoloras latin to erasmus greek renaissance classical bilingualism as a european phenomenon 13971536 | erasmos hypothesizes that in contrast to the tenet the great age of latingreek bilingualism especially in its written form is not to be situated in antiquity instead classical bilingualism flourished in the renaissance a pivotal period in canonizing classics after 1397 when m chrysoloras started teaching greek in florence classical bilingualism developed into an authorial ideal championed by writers like erasmus d1536 this ideal pervaded countless genres far beyond classical standards it turned into a common practice shaping europes cultural identities across the republic of letters where latingreek codeswitching occurred on a daily basiserasmos opens a new research avenue on renaissance classical bilingualism in its own right which offers broader opportunities the project has 3 main aims 1 it inventories classical bilingual sources from the long 15th century 13971536 in a database in order to create a new detailed heatmap of european humanism 2 it develops digital tools for the analysis of literary multilingualism leading to a new form of digital humanitiesassisted closereading most notably the novel tongueprint tool will allow us to automatically calculate the linguistic makeup of texts this tongueprint aims to further integrate multilingualism into neolatin studies by crossfertilizing the field with historical sociolinguistics 3 erasmos analyzes through dhassisted closereading the forms and functions of classical bilingualism in comparison to its ancient pendant thus testing the core project hypothesiserasmos in sum brings culturalhistorical and digitalconceptual innovation the tools developed will benefit humanities studies more broadly and will help us save a key part of european cultural history from oblivion the project promises major advances in the study of europes classical bilingualism which connected the continents brightest minds in an age that fell prey to divisive ideological forces |
the onlineoffline nexus in cybercrime examining online and offline pathways into and out of cybercrime | cybercrime is on the rise and the digitization of crime raises an array of fundamental questions the cybercrimepathways programme focuses on one of the major issues in criminology today changing offline and online pathways in and out of cybercrime individuals do not become cybercriminals overnight they tend to move through different stages with each stage bringing them a little closer to crime involvement the opposite is true for desistance the process of quitting crime whereby each step takes individuals further away from criminal activities together these stages are called pathwaysthe overarching aim of this study is to acquire fundamental knowledge on pathways into and out of cybercrime without knowledge about the pathways it remains unclear if existing theories can still be used to explain cybercriminal activitiesa recent systematic review of the literature shows that the empirical evidence on the factors leading into cybercrime is often incomplete weak and fragmented and that there is a gap between insights from qualitative studies and quantitative studies on the potential drivers of recruitment the programme will go beyond the existing literature and propose a mixed method design that combines muchneeded explorative qualitative insights with rigorous quantitative field experiments using unique qualitative data a combination of interviews with criminal and ethical hackers and police data mechanisms will be distilled and experimented in studies with rigorous experimental designs criminological research using online platforms is scarce however the pioneering work conducted by both my colleagues and me confirms that these platforms are most promising for performing experimental studiesto reconceptualize and futureproof traditional theories the programme will study both cyberdependent and cyberenabled crimes which will enable us to identify the similarities and differences between those two types of cybercrime |
researchers for humanity 20222023 | the main goal of researchers for humanity 20222023 will be to bring researchers closer to the general public and to increase awareness of research and innovation activities with a view to supporting the public recognition of researchers creating an understanding of the impact of researchers work on citizens daily life and encouraging young people to embark on research careers we will also focus on promoting the european dimension of the event and on increasing the publics awareness making european researchers night 2022 and 2023 editions the most interesting and awaited events in terms of science research and education the two editions will be linked with continuous activities related to researchers at schools and preevents and the results of these activities will be presented to the public at the actual events during the events the public will have the opportunity to better understand science projects and researchers ideas and motivation by taking part in interactive handson sessions learning by doing education through play as well as being encouraged to have interesting talks with the researchers themselves our widely spread national network of cities involved in organizing european researchers night will continue to be an important factor when it comes to increase awareness among the general public promoting the goals of the event and creating a large community of researchers involved based on the longlasting relationships the partnerships will be carried on with the main actors from massmedia and most of the important players in private research universities and nonformal education institutions and through researchers at schools activities the number and quality of these partnerships will significantly improve |
european forest research and innovation ecosystem | the eufore project supports the preparation for a possible european research and innovation partnership on forests under the horizon europe programme it aims to develop a sustainable transnational cocreative environment to define implement and evaluate research and innovation ri agendas and roadmaps for the entire forestbased value chains in europe the project will assess and outline research needs and provide a platform for increased ri cooperation coordination and joint funding for forestry and the forestbased sector thus supporting the implementation of the new eu forest strategy eufore outputs include a strategic ri agenda for forestry and the forestbased sector sria along with accompanying implementation measures and stakeholder commitments these will be codesigned with key relevant actors in a multiactor approach the project team will facilitate and strive to implement broad stakeholder engagement via diverse participation mechanisms all designed to instil a sense of coownership of the sria preparation process and thus secure support for its implementationto enable its stakeholders to reach informed decisions eufore will provide them with all the relevant information that is needed in formats suitable for a wide range of audiences this will entail a review of european ri activity in the sector funding and governance information on societal expectations towards the sector analysis of the policy environment and its ri implications and foresight on how the sector might develop and what the future supply of and demand for its ecosystem services and products may be |
mastering electronic doping in tinhalide perovskites to develop near infrared light emitting diodes | as a key advancing technology nearinfrared lightemitting diodes nirleds cover nearly all aspects of our daily life due to their supported large applications such as biomedical imaging optical communication security and data storage with extensive efforts the efficiencies of leds have been improved by over 20 in the emission range below 800 nm however the development of nirleds over 800 nm is modest due to the fundamental limitation of emitters recently tinhalide perovskites thps have emerged as one of the most promising candidates for nirled application through easy composition engineering the emission of thps can be readily tuned from 680 nm to 1000 nm meanwhile the lowtoxic snbased perovskites follow the requirements of the european green deal which ask for reducing pollution to enhance the protection of human life animals and plants however the excessively high ptype doping in thps which reduce the carrier injection efficiency and radiative recombination efficiency currently limits the development of thpbased nirleds this project madled will promote the development of nirleds by developing novel strategies to increase carrier injection and recombination efficiency the results of this project will advance the knowledge about nir emissive semiconductors and be of value in other fields such as solar cells detects transistors etc this will be achieved by integrating deep knowledge of materials science with expertise in advanced opticalelectronic spectroscopies in the host istituto italiano di tecnologia italy besides a secondment helio display materials united kingdom is planned to define a suitable route to industrialization after training in this project i will have an increased set of research and transferable skills and competencies which is critical to enhancing my employability and career prospects |
new pathway and smallmolecule compounds for parkinsons disease therapy | parkinsons disease pd is a neurodegenerative disease with growing incidence more than 10 million people worldwide are affected by this condition in addition to decline in the patients quality of life the economic burden of pd is estimated to exceed 139 billion eur in eu annually considering this novel and more efficient therapeutic options are needed as current pd treatments alleviate symptoms without stopping neurodegeneration and progression of the disease although the etiology of pd is unclear degeneration of dopamine da neurons has been shown to result from certain genetic mutations toxins and pathological protein aggregation among others importantly recent evidence points to decrease in mrna methylation at adenosine n6 m6a in pd data also indicate that m6a reduction may induce da neuron apoptosisprof mart saarma and collaborators have discovered that m6a methylation is a crucial regulator of neuronal apoptosis they developed novel m6a methyltransferase activators and demethylase inhibitors that potently enhance mrna m6a levels importantly preliminary data show that these compounds protect da neurons from neurotoxininduced death in culture at nanomolar concentration moreover one compound tested thus far remarkably improves motor behavior protects and regenerates da neurons and their axons in rat pd model more potently than gold standard gdnf considering this the current project aims to elucidate the mechanisms how m6a regulates da neuron survival and axonal regeneration we will identify for the first time the mrnas with increaseddecreased methylation at adenosine n6 that regulate the life and death of da neurons thereby potentially opening new directions in pd research in addition we aim to provide completely new lead molecules for pd treatmentin conclusion the current project aims to broaden our understanding on the mechanisms of parkinsons disease and provide new drug candidates for novel pd therapeutic avenues |
energy driven pattern formation continuous symmetry breaking and positive temperature | spontaneous pattern formation is an ubiquitous and fascinating phenomenon in nature of enormous importance for the present and future of applications a crucial aspect both at zero and positive temperature is that in dimension d1 the physical states retain less symmetries than the interactions involved in the models this phenomenon known as symmetry breaking coupled with nonlocality makes any attempt of giving a mathematical explanation of pattern formation extremely challenging and still largely not accessible with the current toolsendrisp aims at gaining deep insight into the mathematical mechanisms behind the phenomenon of energydriven pattern formation focusing on the following foremost questions in the field explain continuous symmetry breaking mechanisms for isotropic functionals show pattern formation and symmetry breaking in the positive temperature settingthe focus of endrisp will be on the formation of periodic onedimensional structures in general dimension ie stripedlamellar structures as they are generally the first type of patterns to emerge from uniform phases when symmetry breaking occurs in regimes in which the attractive and repulsive forces are of the same order we will use precise nonlocal quantities of geometric character coming from the free energy to control the curvature of the physical states and derive rigidity and stability estimates the techniques we developed to show pattern formation for continuous functionals retaining discrete symmetry together with our experience on representation theorems in the positive temperature setting and the new ideas in endrisp will be the ideal basement to the project major advances in calculus of variations geometric measure theory and statistical mechanics will be required for which the transfer of knowledge with the supervisors empowered by the unique training offered by courant institute in the outgoing phase and by gssi in the return phase will be extremely beneficial |
interstellar chemical evolution probing hcn and hnc formation and destruction on icy surfaces with computational chemistry | hcn and hnc are routinely used by astronomers to trace temperature and dense gas regions in galaxies where stars and planetary systems form they are key precursors of complex species including prebiotic molecules like amino acids and nucleotides while their gasphase formation and evolution are well understood their formation and destruction paths on interstellar ices remains largely unchartered territorythe aim of this proposal is to remedy this knowledge gap by investigating the formation of hcn and hnc through cn radical hydrogenation on interstellar water and co ices as well as their destruction paths using stateoftheart computational chemistry and astrochemical modelling including in all cases their deuterated counterparts it also presents an opportunity to study the interaction of cn radicals with ice surfaces which can occur either through physisorption or hemibonding on both types of ices the four primary objectives of this proposal are i to explore the cn to water and co ice binding energy distribution as well as the dominant binding modes ii to quantify the hydrogenation reactions of cn with atomic and molecular hydrogen forming hcn and hnc as well as other possible hydrogenation products due to the hemibonding interactions iii to investigate the destruction of the products in the previous point resulting from further hydrogenation reactions and finally iv to calculate the rate constants including quantum tunnelling and implement these in the uclchem astrochemical model to assess the importance of surface chemistry in two specific cases the shocked region l1157b1 and the ngc1068 galaxythe novelty of this proposal lies in the combination of computational chemistry and astrochemical modelling to unveil the icesurface formation and evolution of hcn and hnc and their deuterated counterparts for the first time encompassing a comprehensive characterization of the cn to water and co hemibonding interaction |
gender and diversity index for a fair competitive resilient and sustainable europe | the gendex mission consists of the development of the pilot innovation gender and diversity index providing consistent information currently missing or fragmented to startups scaleups corporates the eic other investors and funding bodies market actors and policy makers across europe the overall aim is to improve the availability of all talent particularly female talent to the eic portfolio of projects and companies and the eu innovation ecosystem for the first time ever a gd index will be elaborated including a wide range of indicators related to gender but also to diversity factors covering all european member states plus the uk gendex will review the existing baseline and access a high number of data sources but it will bring a unique value by carrying out additional primary research both at quantitative and qualitative levels data sets will be assessed gaps will be identified a more standardbased approach to data will be suggested all resulting in a richer definition of indicators and hence a gd index that will become a reference in europe supporting evidencebased decisionmaking a full report on the index will be released with complementary material including a webbased interactive dashboard that will enable smart data visualizations and a widget that will be used for company selfassessment and as a potential data collection tool a wide dissemination communication and awareness campaign will be implemented to ensure engagement and maximize the adoption of the gd index the gendex consortium comprises a complementary set of recognized partners that includes idc european women in vc and bluspecs authors of some of the key works in the field and also a guarantee of the best possible networks for stakeholder engagement such engagement will ultimately lead to maximization of the use of the gd index and hence of its impact gendex will also run a 2phase validation with an experts group composed of at least 18 senior leaders |
the development of biosupported homogeneous organocatalysts with improved recycling potential through sequential de and repolymerization and their use in co2 valorization catalysis | the use of homogeneous catalysis is currently limited as they lack the ability to be easily recycled and thermal deactivation of the catalyst cannot be always avoided these features present important hurdles for the application of homogeneous catalysts in commercial processes and represents an open challenging designing ways to bridge the advantages properties of homogeneous and heterogeneous catalysis through the creation of supported homogeneous catalysts with welldefined active sites having high stability and recycling potential creates new incentives for circular type homogeneous catalysts with application potential in synthetic chemistry in this project several approaches are presented to realize this challenging goal first wellknown nheterocyclic bases such as tbd and dbu will be immobilized onto a biobased polycarbonate and their activity optimized in the synthesis of glycidol carbonate by a sequential catalyst testingdepolymerizationrepolymerization approach the depolymerization will be facilitated by a base catalyst while the repolymerization will be carried out through a known procedure developed at the host laboratory this allows to optimize and finetune the catalyst structure in terms of active site separation concentration and local microenvironment in order to be able to extend the recycling of the catalyst components to a fully recyclable system a crosslinked version will be created and tested during an industrial secondment a second strategy builds on a controlled copolymerization of prefunctionalized biobased monomers that feature two separate catalyst components their successful copolymerization and variation of their relative ratio permits the optimization of the catalytic activity of this binary system in co2 valorization through a similar catalyst testingdepolymerizationrepolymerization sequence and ultimately to a generic process that allows to recycle a homogeneous catalyst through a unique approach |
development of heating technologies for the efficient renewable energy consumption of co2neutral downstreamprocesses | the aim of eeco downstream is to enable a clean steel production by developing advanced and breakthrough technologies for the steel making downstream processes this will decisively support the eu in achieving its goal towards climate neutrality by 2050eeco downstream focuses on the efficient utilization of hydrogen biogas and electricity to substitute carbonbased fuels and drastically lower the carbon footprint of the steel production energy efficiency is pursued to enable sustainable utilization of volatile green energy currently installed burners of reheating furnaces will be enabled to utilize green h2 by integration of newly designed and 3dprinted burner components instead of replacing entire burner systems to increase fuel flexibility hybrid heating concepts h2 and electricity will be investigated in a pilot walking beam furnace since the mentioned solutions will change the waste heat streams and their heat recovery in future downstream processes must be reevaluated this will be done by analysing the partners processes and plants development and testing of waste heat recovery concepts and recuperators regarding their suitability to new fuels and their off gases while considering their impact on materialsproduct energy efficiency potentials of downstream processes will be evaluated by case studies for the application of hot charge from casting to hot rolling by covering of the slabs with passive and active panelsthe elaborated solutions will be assessed by technoecoenvironmental analysis to evaluate their applicability and to increase their acceptance in the steel communitythe eeco downstream consortium has a deep and shared knowledge of iron and steel making downstream processes and heating technology materials engineering numerical simulation experimental investigations economy and life cycle analysis |
hunting dormant black holes in the galaxy with sdssv | stellar evolution models suggest that there ought to be 10e7 stellarmass black holes bhs in our milky way however we currently know only of 20 bhs and those are in binaries where accretion makes them shine in xrays beyond that no nonaccreting dormant bh has ever been robustly identified across the galactic disk finding dormant bhs in binaries dbhbs is fundamental to learning when which bhs form how massive stars die and what the precursors of bh gravitational wave events are such bhs cause characteristic time variations in radial velocity rv flux and lightcentroid positioning of their luminous companion providing an avenue for detection and study spectroscopic astrometric and photometric surveys now yield the data needed to search for dbhbs yet recent dbhb candidates have instead turned out to be shortlived evolutionary phases of close binary stars thus any successful search for dbhbs must entail sifting through vast samples using a combination of these signatures and rigorously eliminating false positives i propose an unprecedented search for galactic dbhbs that should find 100 of them drawing crucially on the spectra of 580000 massive stars from the sdssv survey as sdssv project scientist i have helped shape it as the only allsky multiepoch spectroscopic survey systematically focused on stellar physics novel analysis of these spectra will be meshed with detailed modeling of tess light curves and gaia astrometry through guaranteedtime highresolution followup spectroscopy on the candidates we will get detailed rv curves and crucial spectroscopic disentangling to identify false positives that have two luminous components either dbhbs do not exist in any numbers in our galaxy or this proposal will find and characterize them beyond the risky search for dbhbs this program will break ground in identifying numerous other dark companions to massive stars such as white dwarfs or neutron stars |
speciesspecific aspects in eukaryotic mrna translation modulation and their implications in diseases | mrna translation is a universally conserved process consisting on translating the genetic code into proteins the primary building blocks of all living organisms translation is mainly operated by the ribosome a hybrid molecule made of rnas and proteins in most eukaryotes at least two types of mrna translation coexist in nearly all cells indeed although the quasi totality of the proteins is translated in the cytosol by the cytosolic ribosome a small yet essential fraction of mrna translation can take place in the mitochondria the cells power plant while mitochondrial translation process has proven to be substantially speciesspecific numerous speciesspecific structural and regulatory differences also exist in the cytosolic translation process in spite of their relative conservation among eukaryotic species and are yet to be elucidated we will use various structural and molecular biology methods to investigate from a diseaserelated perspective several speciesspecific aspects of mrna translation modulation in mammals and in pathogenic parasites from the family of kinetoplastids namely 1 we will investigate the molecular roles of several kinetoplastidspecific proteins involved in translation and evaluate their validity as pharmacophores 2 we will study mitochondrial translation in kinetoplastids and focus on its variable regulation in different forms of the parasites during their lifecycle blood vs insect stages 3 we will study cytosolic mrna scanning for the startcodon during translation initiation to i understand its molecular basis in different types of mrnas native and modified mrnas natural or artificial ii and investigate its alteration in colorectal cancer caused by the absence of a ribosomal rna modification results will advance our knowledge of speciesspecific mrna translation and open new perspectives for developing treatments against various human diseases and infections antiparasites cancer therapy mrna vaccines |
breakthrough fuel cell technologies for aviation | the proton exchange membrane fuel cell technology emerging from the automotive industry is of high interest for the future aeronautic industry while automotive industry fuel cell fc systems are usually limited to 100 kw aircraft require a significantly greater amount of power multimw and must operate at both different temperatures and pressures while keeping the systems safety and reliability levels to aeronautical standardsbrava will develop breakthrough technologies for a fcbased power generation system pgs for aviation the overall target is a highperformance pgs with a power range of over 2 mw the foreseen future multimw system will be a multistack aircraft propulsion system airbus reckons that several of such multimw fcbased pgss can be used to propel an aircraft capable of carrying up to 100 passengers on distances of up to 1000 nautical miles advances in the fc stack and balance of plant components the thermal management system heat exchanger design and technology and air supply system architecture will act as building blocks for this multimw fcbased pgs the key project results arenew catalysts and membranes with higher performance durability and higher operating temperature capability to enable integration into new membrane electrode assemblies to reach high efficiency low weight compactness and long lifetime 2phase cooling based thermal management system including a newly designed fuel cell stack for compactness weight reduction and hence improved fuel consumptionadditive manufactured heat exchangers for increased heat rejection compactness lightweight and low draga new air supply architecture and components designed and optimized to provide low parasitic power and weight reduction and thus enabling lower fuel consumption and equipment costeach of the breakthrough technologies for these fc system subsystems will be advanced to trl5 ie technology validated in relevant environment |
descending control of motor circuits in drosophila | understanding how neural circuits control arm and leg movements is a major challenge in neuroscience with implications for treating movement disorders designing neural prostheses and robotics limb movements are coordinated by lowlevel motor circuits in the spinal cord in vertebrates or ventral nerve cord in invertebrates which receive movement instructions from the brain via a small number of descending neurons dns dns constitute the critical link between the brain and the body however despite their importance little is known about how specific dns are recruited depending on the behavioral context and how lowlevel motor circuits in the spinal cord or ventral nerve cord translate dn activity into limb movement i propose leveraging cuttingedge tools to tackle these fundamental questions in the compact nervous system of the fruit fly drosophila melanogaster the flys neural circuits for controlling limbs are more tractable and experimentally accessible than those of vertebrates but still similar in their organization and function focussing on dns that have been implicated in the control of walking speed i will characterize the activity of dns during behavior identify the target neurons of dns in motor circuits in the ventral nerve cord and quantify the influence of dns on these target neurons by combining intracellular patchclamp recordings calcium imaging and movement tracking in behaving animals with computational modeling and connectomics the proposed research project will provide unique mechanistic insight into the interactions between the brain and lowlevel motor circuits that have remained elusive in other animals |
brainwide processing and wholebody biophysics of directional sound | locating sound sources such as prey or predators is critical for survival in many vertebrates terrestrial vertebrates achieve this by measuring the time delay and amplitude difference of sound waves arriving on each ear for fish however the faster speed of sound in water and the proximity of the two ears make such cues useless yet directional hearing has been confirmed behaviorally and the mechanisms have puzzled researchers for decades theoretical studies attempted to explain this remarkable ability proposing that acoustic pressure and particle velocity signals must be measured separately and then be compared however the locus of this computation is unknown and its neuronal and biophysical mechanisms remain obscure this is because most vertebrate brains and inner ears are highly opaque rendering them inaccessible to systemic optical investigation addressing this challenge we recently identified the teleost danionella translucida dt as a unique vertebrate model for neuroscience dt are among the smallest living vertebrates and are transparent throughout their lifespan despite having the smallest known vertebrate brain they display a rich set of complex behaviors including acoustic communication illustrating the ethological relevance of hearing for this species building on our experience with acoustics and brainwide imaging we will exploit this model to 1 image the vibrational response of the inner ear 2 study the neuronal activity of the sensory epithelia and 3 follow the neuronal integration of sensory signals by circuits across the brain with functional imaging these measurements will for the first time allow us to study the entire acoustic processing chain from acoustic stimulus via mechanical transmission to brainwide neuronal integration at single cell resolution if successful they will constitute a major step for our understanding of hearing mechanisms in fish and illuminate the evolutionary origin of vertebrate audition |
sns collaborative operations and output optimisation | the sns coop project is devoted to supporting and facilitating the activities of the sns initiative under the smart networks and services joint undertaking sns ju the sns coop project will achieve this by orchestrating and organising strategic activities in collaboration with the sns ju office and the 6g industry association to capture and promote the european industry view on 6g the achievements of the 6g sns initiative and projects and to promote the ambitions of the sns ju the sns coop project will build on the strengths and assets of the platforms and communities established through the sns ops and sns ice work to stimulate and align complementary activities across the wider community of 6g sns stakeholders sns coop will also ensure the long term continuity of the sns facilities for subsequent phases of the sns ju in addition the sns coop project will provide the support for the eucnc 6g summit events in 2025 and 2026 building on the 6gstart achievements and experience the sns coop project will provide an experienced competent project team that builds on the recent experiences of the sns ops and sns ice projects team to guarantee a seamless handover of all sns support activities for maximum efficiently and value the sns coop project proposes a comprehensive workplan that from the experience of the participants will deliver the expected outcomes and impacts as specified in the work programme particular care was taken to dimension the tasks appropriately for the likely scale and significance of the contributions from the projects the sns coop team will use measurable parameters to regularly assess the dissemination and communication effectiveness which will facilitate monitoring and improving the suitability and quality of the project work with a view to maximising the expected impact of the sns initiative in partnership with all running sns projects |
small molecule heparanase inhibitors as antimetastatic cancer drugs | the heparanib proofofconcept project aims to establish the feasibility of our unique small molecule heparanase inhibitors as drug candidates for the treatment of metastatic cancers to strengthen our science case experimental development a and by building on our in vivo data in mouse models for metastatic breast cancer lung cancer and multiple myeloma we will ai design a suitable route of synthesis to prepare sufficient quantities of clinical grade material aii synthesise reference compounds and aiii perform initial pharmacokineticspharmacodynamics pkpd studies with the aim to prepare for the establishment of a spinout biotech company business development b to take our leads towards the clinic we will biv strengthen our intellectual property ip position bv perform an extensive analysis of the antimetastatic cancer drug market and bvi prepare for commercialisation by consolidating the results in an investorready business plan to develop and commercialise our anticancer drug candidate |
economic and financial impacts from rapidonset compound and cascading climate related risks | rapidonset hazards often compound ie combination of multiple hazards or cascade ie when a single hazard triggers a sequence of secondary hazards being a main source of concern for disaster and financial risk mangers due to the potential massive direct eg capital stock destruction and cascading indirect economic eg employment and gdp social eg inequality and financial eg public debt impacts while the current understanding on how rapidonset compound and cascading climate related roc3 hazards interconnect is progressively improving less attention is given to how roc3 risks lead to direct and cascading indirect impacts the research theme proposed in this project proposal will advance the understanding of roc3 risks by building on stateoftheart risk models to tackle three interconnected research gaps related to the need for i identifying which how and where roc3 risks may occur ii reliable roc3 direct impact estimates and iii a comprehensive and dynamic assessment of the cascading indirect impacts of risks building on an innovative analytical framework that integrates disciplines from different scientific fields including environmental social and economic sciences the project will be the first of its kind to develop and apply a comprehensive methodological framework integrating the intrinsic dynamics of roc3 risks and the cascading macroeconomic and financial indirect impacts the researcher and two host institutions will mutually benefit from threeway transfer of knowledge by providing openaccess datasets and opensource software the project results have the potential to inform disaster and financial risk managers and promote the conditions for building resilience to roc3 risks the project is aligned with the sendai framework for disaster risk reduction and the paris agreement |
autoxitus molecular mechanisms and noncell autonomous signalling | cells control their content by balancing its synthesis and degradation autophagy is a key degradation process capable of engulfing large fractions of cells including organelles into doublemembrane vesicles called autophagosomes these fuse with lysosomes causing degradation of their cargo secretory pathways including secretory autophagy offer an alternative option to remove unwanted materials from cells however mechanisms allowing the secretion of larger cellular components are still unknown we identified a novel pathway which we termed autoxitus for self auto exit xitus that leads to the secretion of autophagosomes this proposal aims at defining the molecular mechanism and regulation of autoxitus we will first study how specificity and decisionmaking between secretory autoxitus and degradative autophagy routes is achieved and whether there is crossregulation autophagosomes on the autoxitus route can contain parts of the cytosol but also large fragments of organelles raising the question whether the secreted autoxitus vesicles signal to neighbouring cells in a noncell autonomous manner we aim to uncover the impact of these signalling processes to determine whether and how autoxitus helps to signal stress conditions or may even deliver material or organelles to other cells finally the role of autoxitus in two pathophysiological conditions will be analysed since autophagic processes are key to viral particle release we will study the contribution of autoxitus to the viral life cycle furthermore we will investigate the role of autoxitus in the release of protein aggregates from cells and the resulting seeding propensitythis proposal will give groundbreaking insight into autoxitus its molecular underpinnings and physiological consequences autoxitus will provide the framework for future integration into numerous cellular pathways |
smart material system to enhance the service life of reinforced concrete structures | sustainable development is one of the main challenges that humanity has to face to progress the construction industry strongly influences the achievement of this goal as it heavily impacts on resource and energy consumption waste production greenhouse gas emission the extension of the service life of structures will be one of the measures necessary for this sector to support sustainable development since it can save resources decrease the carbon footprint and reduce waste production reinforced concrete structures rcs represent the vast majority of the built environment so research efforts should be focused especially on this type of structures one of the most promising approaches to prolong the servicelife of rcs is the development and implementation of smart structures being structures able to sense some external stimuli process the information and respond autonomously in real time by using smart materials technologies research on this topic is advancing but it is still a challenge to achieve efficient systemsthe final goal of smash is precisely to develop an efficient smart material system to be implemented in rcs in order to enhance their service life on the way to sustainable development the key enabling technologies to develop this system will be capsulebased selfhealing and voltammetric sensors combined together to produce a synergic effectwith the support of my supervisor prof paola antonaci and her extensive knowledge in the development and characterization methods for innovative building materials the fellowship will train me in the frontier fields of selfhealing and advanced repair technologies complementing my expertise on sensor systems ultimately smash will provide a crucial contribution to relevant research on the reduction of the environmental impact of the construction sector and on the advancement of smart materials to achieve smart structures in order to reach sdg 11 sustainable cities and communities |
matterwave interferometers | the field of matterwave interferometry is emerging as a highlypromising interdisciplinary field at the interface between fundamental science and quantum technologiesphotonicssemiconductor european industry the primary goals of mawi are to use the exquisite control of ultracold quantum matter to implement guided matterwave interferometers and to train young researchers in the emerging fields of matterwave interferometry and quantum sensors based on interferometric schemes the remit of mawi is in the area of novel quantum sensing devices with potential sensitivity enhancement of several orders of magnitude with respect to existing devices achieving this goal requires training the next generation of quantum interferometry researchers to a broad range of topics from fundamental to applied science including both experimental developments and modelling with strong connections to industry and emerging technological trends our training network focuses on the combination of optimal preparation of initial ultracold atomic sources and potentials to control and guide the atoms their combination to build integrated guided atom interferometers for precision measurements eg of rotations and accelerations and technological advances towards their miniaturisation the end goal of a fullyintegrated cold atom quantum device could become a major commercial tool in the coming decade complementing or potentially even hybridising with parallel developments in the photonics and semiconductor industries supported by our stateoftheart facilities our complementary expertise and skills the participation of wellknown european companies and a broad range of established external partners we are poised to make lasting contributions to the scientific and technological developments of integrated matterwave architectures and to the training of the next generation of research leaders who will propel quantum technologies even beyond our current expectations |
gen 4b solid state liion battery by additive manufacturing | am4bat will develop innovative component materials and assemble an anodefree allsolidstate battery assb manufactured by a costcompetitive and sustainable vat photopolymerization 3d printing the objective is to reach a highperformance battery the energy density of 400 whkg and 1000 whl for electric vehicles applications this will be achieved by developing materials including i single crystal nmc811 with superior energy ii lnmo cofree and higher voltage for power am4bat variant iii dopped llzo with different size from 05 to 5m and 50100 nm for higher loading in the hse and iv novel acrylic nanocellulose sustainable photocurable polymer the materials will be optimized for their processing by additive manufacturing am4bat will then validate the technology via 3ah pouch cells reaching trl5 and will carry out an evaluation of manufacturability a full sustainability assessment and a recycling study to support customers uptake identified stakeholder groups as well as other research initiatives will be actively involved to ensure dissemination of am4bat results and broader users acceptance with its ambitious concept based on cuttingedge 3d printed assb and a strong consortium involving the whole value chain from material providers to an oem am4bat aims to overcome the remaining technological obstacles of the gen 4b technology as specified in the work programme and accomplish the urgent shorterterm needs of the battery industry to make gen 4b batteries a viable technology beyond 2025 on longer term the am4bat outcomes will contribute to the creation of a sustainable european battery manufacturing value chain helping the eu to succeed in the electric mobility rollout and accelerate the energy transition |
uncovering the proteomic radial organization within the eukaryotic nucleus | recent evidence gathered in the bienko lab indicates that in addition to dna many nuclear proteins including several transcription factors implicated in cell fate determination are nonrandomly radially distributed in the nucleus of mammalian cells this fascinating observation led me to hypothesize that there exist a broad set of nuclear proteins that are arranged along radial gradients in the nucleus acting as readers of the radial genome architecture within this msca postdoctoral fellowship i aim at tackling this exciting hypothesis by addressing the following fundamental questions i how are nuclear proteins radially arranged in the nucleus of cells undergoing differentiation towards opposing lineages ii what drives and maintains different radial patterns of proteins in the nucleus iii is the radial arrangement of proteins in the nucleus functionally relevant to address these central questions i will first develop an innovative tool to map the spatial arrangement of nuclear proteins radially i will then apply the newly developed method to chart the radial nuclear proteome in human induced pluripotent stem cells ipscs undergoing differentiation towards different lineages finally i will explore the functional implications of the radial organization of nuclear proteins by attempting to rewire nuclear radiality and assessing the effects on gene expression and cell identity this clearly interdisciplinary project aims at finding an explanation in the spatial organization of the genome and the nuclear proteome to a key question arising from cell and developmental biology how lineagespecific gene expression programs are set up with this ambitious proposal i will dive into the exciting field of 3d genome organization while addressing a completely new hypothesis and potentially making groundbreaking discoveries |
advanced technologies for scanning and detection of illicit material for postal services and express courier flows iflows toolkit | preventing and fighting illicit material and dangerous substances postal and courier services flows in eu areas is of top priority however ensuring efficiency speed and continuity in screening and detection tasks remains yet a challenge currently custom police and courier authorities involve a range of screening systems in place but there is still much to do in terms of detection efficacy and creation of intelligence towards risk and threat identification on top of that criminals or smugglers exploit the multitude of flows and easily spot security gaps that allow parcels or letters to be transported within or across eu with relative ease to overcome these constraints iflows proposes a unique approach to assist customs police and postalcourier services in preventing and detecting such crimes by improving operational readiness enhancing situation awareness reducing detection time providing operational efficiency and achieving superior mission performance iflows will design develop integrate test and validate a novel multitier synergistic toolkit in enhancing intelligence extraction screening and detection operations of illicit material and hazardous substances within courier and postal flows moving across and within eu borders iflows works upon these 3 building blocks to deliver a a tailored to such operations c4i that boosts preparedness and cooperation between police customs and courierpostal services b enhanced intelligence in terms of threats risks and suspicious flows and c novel detection technologies ie thz scanning system and uwb scanner featuring enhanced detection capabilities over a large span of illicit material and substances which coupled with advanced imagebased feature extraction in combination to legacy systems eg xray and raman optimise the detection process without interrupting the postalcourier flows |
multihazard and risk informed system for enhanced local and regional disaster risk management | this project will develop a decisionsupport system dss for disaster risk management by considering multiple interacting natural hazards and cascading impacts using a novel resilientinformed and serviceoriented approach that accounts for forecasted modifications in the hazard eg climate change vulnerabilityresilience eg aging structures and populations and exposure eg population decreaseincrease the primary deliverable from mediate will be a decision support framework in the form of serviceorientated web tool and accompanying disaster risk management framework providing end users local authorities businesses etc with the ability to build accurate scenarios to model the potential impact of their mitigation and adaptation risk management actions the scenarios which can be customised to reflect local conditions and needs eg demographics deprivation natural resources etc will be based on a combination of the historical record and future climate change projections to forecast the location and intensity of climate related disaster events and to predict their impacts including cascading impacts on the vulnerability of the local physical economic and social systems the scenarios will allow end users to evaluate the potential impact of different risk management strategies to reduce vulnerability and enhance community resilience the project will consist of analysis of relevant data and codevelopment with testbed decisionmakers of a dss to enable more reliable resilience assessments accounting for risk mitigation and adaptive capabilities to be made therefore reducing losses human financial environmental etc from future climaterelated and geophysical disasters the project will involve a multidisciplinary team of geophysical and meteorological scientists risk engineers social scientists information technologists and endusers working together to ensure that the system is userled and supported by appropriate technology |
genealogies of human capital | genealogies of human capital genhumcap explores the rise of human capital theories between the collapse of the labor theory of value and the world banks recent human capital plan specifically it charts how human life although formally absent from market exchange was rendered tractable to neoclassical practices of valuation and calculated investment then how diverse experts used these methods to reconfigure healthcare development aid and population control programs in the name of maximized future wellbeing using methods from sociology the history of science and the digital humanities the project will gather new data from archives expert interviews and new textmining techniques analyzing the results in light of contemporary french sociological studies of the social sciences it will do so in close dialogue with leading sociologists at the cessp in paris under the supervision of professor gisle sapiro to disseminate its findings the project will result in a conference two academic articles and a book manuscript and in publicfacing summaries in newspapers and eusponsored dissemination projects through innovative interdisciplinary methods genhuc will provide the first substantial investigation into human capital advancing multiple fields by reframing a series of sociological debates on neoliberalism biopolitics and biocapital and creating new connections between the history of science sociology and economics in the process it will cement the base for a competitive research career in european academia |
engineering light induced phase change for emerging nanoscale processes | lightinduced phase change lpc is the unifying theme underpinning many apparently nonrelated processes in i additive manufacturing am for metals where laser induced vaporisation and the formation of keyhole porosity is a major limiting factor for 3d printing ii nanomedicine nm where laser induced nanobubble dynamics and associated shockwave effect is powerful for malicious cell destruction and iii solar energy en where direct steam vapor production from bulk and surface fluid is a promising technology for power and clean water solutions in addition to the challenging multiscale nature of phase change lpc add further complexities by introducing the multiphysics nature due to strong lightabsorber interactions we will tackle the fundamental challenge of the formation and control of lpc and develop a physicsbased platform supported by multiscale experimentation and multiscale simulation as the tool to design and engineer lpc as innovative mechanism for in situ process steering and control five work programs are designed focusing on two complementary paradigms i fundamental studies for enhancing lpc mechanism understanding via developing physicsinformed multiscale modelling validated by dedicated nanoscale experiments and ii application studies for engineering lpc for designed functions towards en nm and am respectively many breakthroughs beyond stateofart work are expected such as i the establishment of a unique multiphysics and multiscale lpc simulation platform ii the revelation of lpc mechanisms by sub 100 nm experiments with localized temperature and nanobubble dynamics measurement and iii the reverse engineering of lpc to maximize solar vapor production inhibit keyhole pore formation and control nanobubble shockwave effects the project will not only advance lpc understanding in the domain of thermodynamics and heat transfer but also transfer the developed expertise into emerging applications |
training and innovation in reliable and efficient chip design for edge ai | artificial intelligence is increasingly being brought to the source of data thus establishing the edge ai concept edge ai is gaining momentum across various industries and services by public authorities and enables new applications requiring high performance ultralow latency with high bandwidth efficient power use and intelligence beyond regular computing its strategic importance is emphasised through the eu chips act monetary investments in the eu semiconductor supply chain highlighting the urgent need for a qualified workforce the advancements in edge ai applications face critical research and engineering challenges related to limited computing and energy resources of the edge devices limitations of the existing ai algorithms and their insufficient fit also the related rapid technological advancements market dynamics interdisciplinarity and regulatory uncertainty set a unique challenge for the valorisation and management of edgeai innovations the general research objective of tiramisu is a practical methodology for reliable and energyefficient edge ai hardware backbone design and innovation managementthe action will provide strong interdisciplinary training for future european engineers and researchers driving the innovation for reliable and energyefficient edge ai chips the consortium is strategically designed to foster crossdisciplinary synergies by seamlessly integrating innovation management research with the technical aspects of edge ai design the nonacademic sector is represented by a european flagship rd hub for nanoelectronics imec a global leader in industrial electronics and the largest semiconductor manufacturer in germany infineon a trusted automotive solutions provider punch the worldwide leader in eda tools development cadence the academic excellence is established by the top ict and technology innovation engineering universities and europes largest applicationoriented research organisation fraunhofer |
ecosystemic resilience against platformization | digital platforms can massively erode the social environment in which they operate for instance shortterm rental platforms strs such as airbnb dislodge vulnerable locals from their homes escalate gentrification and further fuel overtourism urban ecosystems develop organized responses to such disruptions ranging from local social movements to international city alliances which take action to address extensive platformization while the knowledge of the systemic effects of the platformization of society is increasing we still know little about the emergent resilient responses and the further effects they set in gear this project titled ecosystem resilience against platformization erap fills the gap by exploring and theorizing the efforts to counter the negative effects caused by strs erap employs case study methodology to zoom in on four eu cities where the negative effects of strs are particularly visible but the responses are vastly different the fieldwork focuses especially on giving voice to and learning from underprivileged groups eg tenants at risk of losing housing and housing movements complementing that is a longitudinal study tracking the efforts to establish euwide str regulations leveraging the novel interdisciplinary field of digital ecology erap will trace patterns of ecosystemic intensifications eg the loss of affordable housing and the emergent organised resilient responses the analytical emphasis will be on the configurations of social actors mobilised in those processes their tactics the use of digital technology and interconnections eg alliances with the goal of explaining the systemic dynamics of digital resilience erap will contribute to the growing field of digital ecology and inform eus policy on nextgeneration sustainable digitalisation emphasising that the future of digitalization is negotiated among a broad range of stakeholders and across levels from local to transnational |
elucidating the genomic architecture of genetic load | how can we accurately measure and predict genetic load in svload i aim to understand how an often overlooked but high impact class of genomic variation contributes to genetic load structural variants svs have been shown to have significant implications for individual and population fitness and impact more genomic content overall than traditional wholegenomic markers ie single nucleotide polymorphisms snps however wholegenome svs are underrepresented in population studies as they have historically been difficult to characterise and genotype at the populationscale as a result the dynamics of sv diversity in the face of fundamental evolutionary processes eg selection recombination and population size is relatively unresolved and hinders the study of genetic load across disciplines to address this gap i will implement insilico approaches to forecast and experimentally test how svs respond to different demographic parameters in a nonmodel species coelopa frigida during my phd and first postdoc i honed the sequencing and bioinformatic skills necessary to study genomewide svs at the populationscale i will bring this expertise to the host lab of dr mrot and dr glmin at the universit de rennes ur france experts in the field of evolutionary biology and ecology training with the host lab and a secondment with aprof bataillon at aarhus university au denmark will broaden my modelling and experimental skills through these collaborations i will learn new multidisciplinary approaches in modelling statistical genomics and experimentation this project will not only complement my existing skills but enable me to gain a competitive advantage in establishing my european career in the exciting and dynamic field of evolutionary biology finally this project will aid in advancing our understanding of genetic load which remains a fundamental challenge for biologists in the agriculture conservation and evolution research sectors |
explainable trustworthy brainlike ai for data intensive applications | in parallel to the current developments in the socalled narrow artificial intelligence ai realm there is an urgent demand for more universal general ai approaches that can operate across a wider spectrum of application domains with varying data characteristics it is expected that the emerging sustainable ai methods can be efficiently deployed in the edgecloud continuum on different hardware platforms and computing infrastructure depending on the realworld task scenarios and constraints including the limited energy budget in response to this growing demand and emerging trends we propose to adopt a brainlike approach to ai system design due to its promising potential for functional flexibility hardware friendliness as well as energy efficiency among others to this end extrabrain is aimed at developing a new generation of ai solutions based on brainlike neural networks that enable us to overcome key limitations of the current stateoftheart methods exemplified by deep learning such as limited crosstask generalisation and extrapolation to novel domains bounded reliability excessive dependence on costly annotated data as well as extensive training and validation processes with heavy demand for compute resources at high energy cost to name a few the core brainlike neural network design in our approach derives from the accumulated computational neuroscience insights into the brains working principles of information processing key learning schemes and neuroanatomical structures that underlie the brains perceptualcognitive phenomena and its functional flexibility furthermore these novel models are supported by data optimisation pipelines which improve data quality security and reduce the costs of assembling suitable training data and an explainability framework to empower the human user the proposed extrabrain framework will be examined in a diverse set of use cases with different hardware demands in the edgecloud continuum |
novel biophysical tools to measure multiple parameters in the same cell | biophysical biomarkers of cell state can reveal physiologically relevant changes that occur during disease progression for example cell deformability cytoskeletal and nuclear organization and macromolecular crowding are biophysical parameters implicated in migration and growth which are essential processes for cellular functions as biophysical parameters reflect physiopathological cell states they have the potential to be used as biomarkers for early diagnostics and clinical treatments in medicine current techniques based on microfluidics can be used to perform biophysical measurements in a highthroughput manner however these systems are not able to provide multiparameter biophysical and samecell measurements making it difficult to find insightful relationships in heterogenous cellular mixtures samemultiphys will develop and produce customized microfluidic systems to measure multiple features in the same cells and evaluate their potential applications as biophysical biomarkers these new technologies will allow us to study multiscale biological questions of immune t cells from an interdisciplinary perspective and other cell lines this project aims to facilitate the transfer of knowledge and resources between institutions with expertise in microengineering materials science chemistry mathematics biology and biophysics to promote collaboration between researchers and to develop innovative microfluidic technologies for mechanobiology the project will involve stateoftheart microfabrication techniques deeplearning analysis of images and computational modelling to develop and validate the technologies developed the ultimate goal of this project is to gain a deeper understanding of the mechanobiology of cells enabling progress toward more effective identification of biomarkers |
serving the revolution educational networks in communist albania | my research explores the educational networks of albania during the cold war using several archives from albania china italy and east germany as well as conducting interviews the research investigates in what ways educational exchanges impacted albanias economic policies and the formation of an adequate specialised workforce from 1955 to 1978 when hundreds of students were sent abroad to pursue university studies albanias communist past has been little studied this project proposal contends that studying educational networks and expertise circulation would provide a complete understanding of the communist regime of albania during the 1960the overall research objective of this proposal is to understand the impact of the educational networks and expertise circulation in albanias economic policies from 1955 to 1978 the project is expected to have a major impact in the field of east european transnational networks during the cold war and albanias communist history as it will explore for the first time the importance of access to foreign expertise and technology as well as the education of specialized workforce in the building of economic and social institutions in albania historical studies may contribute to the european unions adopting adequate policies towards the balkans an important task in light of recent events in eastern europe with the war in ukraine in the meanwhile the new scientific skills in reading and processing political documents as well as learning didactics in the european union together with research methodologies acquired through the twoyears training at the department of east and southeast european history gose ludwig maximilien university lmu under the supervision of prof marijanine calic will allow me to foster my academic profile as a regional expert in east and southeast european studies thus increasing my chances to continue my career in academia by becoming a research leader in the field of cold war in europe |
attracting international experienced researchers in any research field to the basque country | the economic crisis and the lack of resources devoted to research and development rd in spain is a pressing issue affecting the basque region too and it is aggravated by the european crisis provoked by the covid19 pandemic and the ukraine invasion the rd expenditure of gdp in spain has been reduced in the last decade currently it is half of the european union average which is critical the stabilization of longterm research lines led by experienced researchers as proposed by smartbrain3 is an unmet challenge that ikerbasque beneficiary proposes to address with the present programme smartbrain3 aims to offer 30 research contracts for experienced researchers within 2 calls offering 15 positions in each call the current programme offers permanent contracts as ikerbasque research professors tenure track positions to all researchers to be recruited although each fellowship will last 36 months within the smartbrain3 programme the impact of such a workforce for the basque region is welcomed as internal assessments by the basque research institutions show the lack of experienced researchers in the region smartbrain3 offers an outstanding research innovation training and career consolidation programme with specific focus on the triplei dimension international intersectoral and interdisciplinary as well as providing an impactful innovative and inclusive research environment the 24 implementing partners recruiting and hosting the fellows are leading international institutions within their respective fields smartbrain3 includes mandatory international secondments which enhance the researchers networks and let them explore intersectoral career paths as well in support of their career progress smartbrain3 ultimate impact is to contribute to the challenges and priorities set out in the ris3smart specialization strategy of the basque country the united nations sustainable development goals and the horizon europe |
human based bioinks to engineer physiologically relevant tissues | bioprinting techniques which integrate 3d printing with tissue engineering by using living cells encapsulated in natural or synthetic biomaterials as bioinks are paving the way toward devising many innovating solutions for key biomedical and healthcare challenges and heralds new frontiers in medicine pharmaceutical and food industrieshumanink aims to validate human basedbioinks to produce robust humanized 3d environments with unprecedented biofunctionality for cell culture that fully recapitulate the native microenvironment of a variety of human tissues and organsunder this project humanprotein derivative precursors that can be cured upon light exposure to form soft hydrogels with tunable mechanical properties will be tested and validated as bioinks for 3d bioprinting such materials provide functional support for cell growth and interact with cells to control their function guiding the process of tissue morphogenesis this platform is the first to offer complete humanbased material for bioprinting and an easytouse solution to create physiologically relevant 3d in vitro cell cultures accelerate drug discovery or clinical purposesthe humanink will allow to optimize the printability robustness reproducibility and scalability of the humanbased bioinks the biological response of multiple human cell types will be investigated and the bioinks will be benchmarked with the main competitors in the marketour proposed technology will increase the probability of successful drug development while simultaneously reducing the cost and time of development and supporting animal welfare reducing animal experimentation based on the unique properties of our products humanink represents a unique opportunity to develop materials for tissue engineering and accurate disease models for bridging the gap between fundamental research and drug validation with a high and broad market potential in pharma companies clinical institutions or research groups |
circadian structural transitions of chromatin | transcription factors tfs distinctly mark regions of the genome for expression and are the pillars of cell identity yet even at the basic level of dna recognition by tfs we know very little about how this is achieved in eukaryotes all dnatemplated processes occur in chromatin however most studies elucidating the molecular mechanisms of transcription have been performed on histonefree dna in the proposed project we will use tfs as centerpieces to understand how in the circadian system the interplay between transcriptional regulatory complexes and chromatin shapes the eukaryotic genome to control gene expression specifically we will use biochemical approaches paired with functional genomics and cryoem single particle and tomography to investigate how histone identity affects tfdna engagement and how tfs and histone modifications influence chromatin organization across biological scales from nucleotide sequence to chromatin structure in situ we will exploit circadian time in mammalian cells and the unicellular green algae chlamydomonas to elucidate the dynamic gene regulation of a biological system under natural conditions using diverse model organisms will enable us to reveal common conserved properties and processes ultimately these studies will provide unique insight into the fundamental mechanisms of gene regulation while dissecting the molecular mechanisms of biological timekeeping |
design of intelligent risaided cellfree networks for energyefficient coexistence between embb and mmtc | in our modernized era beyond5g and 6g wireless systems will be key to satisfying crucial society demands the new challenging 6g kpi the renewed need for sustainable and green networks and the introduction of ai and sensing evinces the necessity of incorporating new technologies and of designing novel solutions in that sense cellfree massive mimo reconfigurable intelligent surfaces riss and edge intelligence are anticipated to be key technologies in the 6g era diracfec is a 24months research project that thus concentrates on the design of intelligent risaided cellfree networks for energyefficient coexistence between evolved embb embb and evolved mmtc mmtc more specifically considering usercentric architectures and distributed multiple antenna deployments we will present a set of multiple access schemes edge intelligence techniques and transmission strategies that optimize the energy efficiency in a heterogeneous service environment aiming at the coexistence of embb and mmtc services we will conceive mathematical frameworks to model dense networks where several riss are controlled by multiple antenna access points then to boost the ultimate performance we will design the aforementioned approaches for different types of data traffic under the assumption of imperfect channel knowledge these solutions will be evaluated using numerical and industry level systemlevel simulations in practical setupsthe project will be carried out by the researcher at the university of cassino and lazio meridionale italy under the supervision ofprof stefano buzzi furthermore nokia bell labs france will host the researcher for a sixmonths secondmentaimed at validation of the developed solutions on industry level system simulators the applying researcher is drsergi liesegang a fresh phd graduate from the politechnic university of barcelona spain |
boosting the uptake of circular business model product and process innovation | up2circ will demonstrate a replicable pathway to motivate and effectively support smes to innovate and transform towards sustainable growth and adresses the need of eu innovation support ecosystems to better join forces and make best use of synergies in order to enable a quick and comprehensive transition of europes smes towards a circular economy on a large scale with the up2circaccelerator the project accompanies smes from exploration of opportunities to concrete implementation projects concerning the uptake of circular business model product and process innovation focussing on achievable innovation measures with clear midterm benefits for the smes up2circ is dismantling barriers with a customized clientcentric advisory approach and gives access to specific expertise and skills that smes need to develop a concrete action plan on how to transition learning modules of up2circacademy will connect sustainable innovation the uptake of advanced technologies and social innovation aspects under the holistic concept of a circular economy and will be compiled based on existing results and in close cooperation with eu networks and initiatives such as ati edih eccp eit and oitb up2circ methodology and materials will be made available to sme innovation advisors and trainings will be offered targeting eg een sustainability advisors to upscale project results further to increase efficiency of eu innovation support ecosystems four leveraging effects will be demonstrated and exploited make use of existing results reach out more efficiently to smes make use of complementary strengths establish closer connections |
lifecycle extension of salvaged wooden materials through reuse in dowellaminated timber | reusing salvaged timber in new applications can make an important contribution to circular economy however currently the reuse of such materials is limited especially in structural applications one reason is the lack of demands from the wood sector due to the absence of standard grading procedures and other issues related to eg shape irregularities service damages dimensions limitation and degraded properties which will require costly significant processing that makes salvaged timber less profitable this project will demonstrate how a fitforpurpose approach can be implemented in a practical manner to reuse salvaged timber in structural applications the target application is in dowellaminated timber here ecodlt floor panels in ecodlt salvaged timber will be reused in combination with new raw timber using a new fabrication method that will not require significant processing or gluing this can reduce the processing costs which can make salvaged timber more profitable and more attractive for the wood sector the project will first evaluate the current state of salvaged timber resources in slovenia using resource inventory a resource classification method will be then established using which the reusability and profitability of reusing each resource can be determined objective 1 in the next stage the concept and fabrication method of ecodlt will be developed experimentally and its structural properties will be examined objective 2 analytical models will then be developed for predicting the structural properties of ecodlt using a new wellknown weak points concept which will consider certain strengthreducing features of salvaged timber that are not represented in the existing models objective 3 the project will contribute substantially to the eus circular economy goals and will lead to breakthrough innovation in wood cascading and analytical analysis of mass laminated timber elements with complex configurations |
connecting symmetric and asymmetric cryptography for leakage and faults | symmetric asymmetric cryptography offer the basic functionalities needed to communicate securely over a channel due to their different features and the different algebraic structures they exploit the interaction between the design of these primitives and the security of their implementation against sidechannel fault attacks so far followed somewhat separated paths based on the observation that i many emerging challenges for the implementation security of symmetric asymmetric primitives share similarities and would highly benefit from a more connected approach and ii this is especially true when considering postquantum asymmetric encryption schemes that include symmetric components and for which current designs are extremely challenging to protect against sidechannel faults attacks the bridge project aims to develop a unified treatment of symmetric asymmetric cryptography by leveraging three innovative movements first we aim to export the concept of levelled implementation where different parts of a primitive are protected with countermeasures of varying cost from symmetric cryptography towards new postquantum asymmetric schemes that inherently take implementation security as a design criteria second we aim to export the use of larger possibly prime fields and more complex algebraic structures used in asymmetric cryptography to deliver advanced functionalities towards new symmetric schemes that guarantee security against sidechannel fault attacks in lownoise contexts that raise fundamental challenges for existing countermeasures third we aim to exploit hard physical learning problems as radically new building blocks applicable to both types of primitives by combining these movements we aim to identify disruptive approaches to build new cryptographic schemes offering a better integration between symmetric asymmetric designs and improvements of their implementation security by orders of magnitude |
multimode nonlinear fiber based endoscopic imaging and treatment | multiscope introduces a revolutionary photonic technology that represents a significant advancement in the field of optical diagnostics and therapy our approach is based on cuttingedge research into pulse propagation within nonlinear complex structures we are developing an endoscopic device that seamlessly combines optical biopsy and cold atmospheric plasma treatment this dualfunctionality device harnesses the spatiotemporal control of powerful light in multimode fibers which were previously overlooked due to concerns about excessive light destructuring we leverage the remarkable progress in the development of the latest optical fibers and in the precise control of light within multimode guides enabling us to harness the power of plasma the fourth state of matter initially our focus is on gastrointestinal gi endoscopy but our ultimate goal is to extend this technology to all areas of medical diagnostics where there is a pressing need for reliable tools for optical biopsy and instant pathology these tools are crucial for realtime diagnosis but have not yet reached the level of trustworthiness required for widespread use endoscopy is a vital tool for diagnosing and treating gi disorders offering a safe and effective approach however the current standard of care still relies on histopathology for conclusive cancer diagnosis this leads to significant delays in initiating treatment and incurs high costs our project is set to transform this landscape by bringing to life the longanticipated concept of realtime invivo optical diagnosis often referred to as optical biopsy our groundbreaking approach seamlessly integrates endoscopic capabilities with cold atmospheric plasma therapy which employs controlled plasma jets to precisely target and eliminate cancer cells by inducing cellular apoptosis by combining plasma therapy with optical biopsy we not only provide realtime diagnosis but also offer immediate therapeutic intervention |
mechanical characterisation of nucleic acids using single molecule methods | nucleic acid nasbased therapies have started to yield major advances in the treatment of human disease new approaches for understanding na structure and function are required to extend the boundaries of todays gene editing technologies cancer therapies and mrna vaccines singlemolecule techniques have revolutionised our understanding of nas and their interactions with therapeutic oligonucleotides small molecules and proteins however for europe to remain competitive in this area new expertise is urgently required in singlemolecule na analysis which intersects the fields of physical chemistry biophysics na synthesis and computation mechanism will train the next generation of european scientific leaders in the development and use of singlemolecule biophysics techniques where they will investigate critical interrelated question regarding the structure dynamics function and interactions of nas to do this our doctoral candidates dcs will unravel highresolution na structures and intramolecular forces with modified bases understand the conformation and dynamics of nas at the singlemolecule level develop nextgeneration therapeutics for treating genetic diseasesmechanism connects worldleading researchers working in the fields of singlemolecule biophysics na chemistry and computational modeling with outstanding industrial partners working in complementary fields in addition to conducting worldclass research our dcs will understand industrial needs have knowhow in running multidisciplinary research and will be immersed in a broad collaborative network connecting academia and industry our dcs will provide vital future breakthrough applications in nas and singlemolecule analysis to pharmaceutical and biotechnological industries where the design of new drugs including nabased therapeutics and vaccine technologies will provide major improvements to human health |
bridging the digital divide and addressing the need of rural communities with costeffective and environmentalfriendly connectivity solutions | over the last years the importance and need for broadband and highspeed connectivity has constantly increased the covid19 pandemic has even accelerated this process towards a more connected society but this holds mainly true for urban communities in europe a 13 lack access still persists and mainly concerns the most rural and remote areas those are the most challenging to address since they are the least commercially attractive commect aims at bridging the digital divide by providing quality reliable and secure access for all in rural and remote areas the goal of extending broadband connectivity in rural and remote areas will be achieved by integrating nonterrestrial networks with terrestrial cellular xg networks and lowcost internet of things iot artificial intelligence edge and network automation will reduce energy consumption both at connectivity and computing level participatory approach with endusers and ict experts working together on development challenges will be the key for the digitalization of the sector to ensure the rich exchange of bestpractice and technical knowledge among the actors of the agroforest value chain commect will set up five living labs across and outside europe where endusers pain and connectivity gains will be largely discussed from different perspectives commect aims at contributing to a balanced territorial development of the eus rural areas and their communities by making smart agriculture and forest services accessible to all commect will facilitate that by developing a decisionmaking support tool able to advise on the best connectivity solution according to technical socioeconomic and environmental considerations this tool incorporating collaborative business models will be a key enabler for jobs business and investment in rural areas as well as for improving the quality of life in areas such as healthcare education egovernment among others |
sustainble alternative to flexible packaging | paptic foam is a new material for flexible packaging combining the sustainability of paper versatility of plastics and haptics of textiles our material is compatible with the production processes of the respective flexible packaging value chain thus can be easily introduced in processing the unique haptic properties also enable consumers to differentiate the products improving efficiency of sustainability communication of endusersbrand ownerspaptic already has developed and piloted the foam technology to produce renewable recyclable and reusable woodfibre based material that is over 50 more resource efficient compared to paper paptics patented material technology has vast application opportunities in various flexible packaging market segments like dry and frozen food packaging electronics hygienic products toys etc our technology enables resource efficient manufacturing and higher product performance enabling position of most sustainable alternative to plastics |
critical geopolitics of nuclear fuel supply in europe | how do countries build their nuclear fuels supply policies the ongoing political renaissance of nuclear power through the world raises concerns about european union states ability to fill their needs despite efforts to build a common strategy eu members follow diverging paths to secure their supplies however energy security studies are so far unable to explain this heterogeneity creating miscomprehensions between countries and illinforming energy policies first we lack any empirically informed works on the geopolitics of nuclear power second all theoretical frameworks studying supply security were built over hydrocarbons but if we want to decarbonize our societies we will first have to decolonize these tools from the grip of fossil fuels third while critical security studies have called for more spacesensitive approaches engagement with political geography theories remains limited geonufe aims at filling these gaps by questioning the variables behind the spatial heterogeneity of nuclear fuel supply strategies to do so i develop an innovative analytical framework bridging critical security studies and critical geopolitics through their ongoing turn to new materialist approach and assemblage geonufe will compare four countries france finland the uk and hungary following three steps 1 ill confront the current fossilfuel informed theories to actors of the nuclear sector to build the first ever analytical framework of objective supply security adapted to it and apply it to the four countries 2 ill identify the influence of eu membership by digging into how the euratom supply agency who is responsible for allowing supply contracts to member states produces and performs security 3 i will trace and compare the geopolitical assemblage which explains the supply strategies in each country expected results will provide essential knowledge of the geopolitical dimensions of energy transitions to better inform eu energy policies |
the transversal social impact of gold metallurgy in ancient societies a diachronic approach from prehistoric iberia | goldenimpact aims to understand the social impact of gold technology implementation in all sectors of society and surpass outdated traditional narratives that solely understand gold as a consolidator of elite power hence the project targets the study of gold production by 1 characterising existent technological traditions 2 understanding the social consequences of metal crosscraft interactions affecting gold production and 3 evaluating the extent and degree of novelty of the structural changes necessary to sustain gold production iberia was selected as case study 31001500 bc for being an archaeologically rich area with an autochthonous development of metallurgy and outside of the traditional research loci of ancient gold technology in eurasiato accomplish these objectives this project uses a radically interdisciplinary methodology that combines knowledge from archaeology anthropology and geology with computational tools r qgis and materials science techniques optical microscopy pxrf icpms to analyse selected gold items and deposits as a result it will be possible to reverse engineering and socially contextualise ancient gold production strategies and explore the links between technological and social change from a previously overlooked perspective ie gold production this will contribute to resignify gold as a symbol of the achievements of nonelite people and ultimately generate a more balanced narrative within the european history of technology taking into account all society sectors and europes eastern periphery |
digital finance reaching new frontiers | a competitive european financial sector is vital for the modernisation of the european economy across sectors and to turn europe into a global digital player we have identified the five most pertinent areas within this domain towards a european financial data space artificial intelligence for financial markets towards explainable and fair aigenerated decisions driving digital innovations with blockchain applications sustainability of digital finance for this purpose we have gathered an internationally recognized network consisting of nine leading european universities wu vienna university of twente bucharest university of economic studies babesbolyai university bern business school kaunas university of technology university of naples university of poznan university of kaiserslauternlandau all ranked among the top 200 universities globally in their fields three major international corporations swedbank deutsche bank and raiffeisen bank with a significant rd presence across europe two smes cardo ai and royalton partners being some of the most innovative ones in their field three large and internationally renowned research centres arc greece eit digital and fraunhofer institute germany the bank for international settlements and the european central bank as one of the seven principal decisionmaking bodies of the european union and the euratom as well as one of the worlds most important central banks the results of the research carried out within digital are of substantial interest to three leading europeanwide research networks that our members either lead or serve on the management committee for cost action ca19130 240 researchers across 39 european countries ecmi and the european consortium of innovative universities 13 european universities it is only through a network that incorporates the expertise of all distinct shapers of the financial industry that we can see a comprehensive shift towards innovation and digitalization of a sector that is notoriously averse to change |
universal description of the bose gases | in unibogas my aim is to prove universal expansion formulas for the low energy levels of the dilute bose gases showing their dependence on just one parameter namely the scattering length of the potentials between the particles i am going to work out to which order of precision of the expansion the universal description still holds and for which kind of systems the classification of the systems that satisfy the universality is obtained through studying the expansions in three directions by paradigmatic examples i am going to evaluate the energy for systems with potentials with repulsive and attractive parts i am going to approximate the energy of systems composed by two kinds of bosons by the energy of effective nonlinear models and i am going to evaluate the low energy levels of the hardspheres hardcore potential systemthe methodology used includes both the improvement of preexisting techniques in the bogolubov theory and the introduction of new methods of localization semiclassical analysis and variational methodsother than on mathematical physics the results of unibogas will have an impact also on disciplines like functional analysis experimental physics and quantum chemistry for the bose gases and will contribute to further understand the phenomenon of bose einstein condensation |
experimental aircraft for european leadership in aviation | the objective of exaelia is to investigate and to answer the needs for novel flying testbeds for derisking the development of disruptive future longrange aircraft accelerating the reduction of all aviation emissions and its climate and environmental impacts in 2050exaelia investigates through advanced multidisciplinary digital methods the potential emissions reductions of longrange air traffic offered by promising blended wing body aircraft configurations and by hydrogenpowered tubeandwing configurations including their constituting radical new technologies critical uncertainties are identified in particular those requiring flight validation for derisking the future aircraft development for those flight test requirements which go beyond the capabilities of existing assets novel flying testbeds are developed towards their preliminary design and demonstrated to answer the flight validation needs efficiently combining these needs in potentially costly largescale modular flying testbeds roadmaps are prepared for the further development of the exaelia flying testbeds and their use in the development of the future longrange aircraft entering into service before 2050 with a maximum contribution to reducing aviation impact and emissions 49 of air transport system emissions in 2019 came from long range aircraft operational and business plans for these indispensable test bed assets are provided as wellthe exaelia consortium consists of the major european research centres and academia in future aircraft conceptual design and analysis flight testing and flying testbed development and 4 smes all with a strong record in collaboration an advisory board including european aircraft and engine manufacturers and further industries will provide guidance to achieving the objective and to obtaining their support to the roadmaps the total grant request of this 42month action is 16 233 889 euros |
integrating terrestrial and aquatic archaeozoological studies venice and the northern adriatic lagoons between antiquity and the early middle ages | the inter aquas project aims to investigate humananimalenvironment relationships at the romanearly medieval transition along the northwestern adriatic coast by highlighting elements of continuity and discontinuity the project aims to contribute precious knowledge to the archaeology and history of this transitional period the project will analyse archaeozoological assemblages from three studyregions the venetian lagoon the maranogrado lagoon and the coast of romagna these regions are characterised by the presence of wetlands with lagoons rivers and canals influencing the nature of human settlement and activities the archaeology of the late antiquity and middle ages in the northwestern adriatic represents a very active field of research current archaeozoological analyses however are sitespecific while largescale reviews touch these regions only lightly and marginally without focussing on their peculiar environmental contexts the chronological and spatial comparisons proposed by the inter aquas project the combination of terrestrial and aquatic faunal studies and the functional implementation of biometrical and stable isotope analyses will provide a holistic approach taking into account the complex changing relationships between humans other animals and the environment my experience in archaeozoology and in particular my familiarity with biometry and the romanearly medieval transition in europe make me the ideal candidate to conduct a project such as inter aquas ca foscari university of venice is a leader in the study of the late antiquity and middle ages in italy and the project will ultimately fill the existing gap in largescale and methodologically targeted faunal analyses in addition to informing on key aspects of past economies and environments this study will boost my knowledge on the archaeology and history of the periods considered and substantially advance methodological skills required to optimise my career prospects |
synaptic resilience in tauinduced neurodegeneration | dementia is an enormous burden on society patients require lifelong care and there is no cure or symptomatic treatment at early phases dementia is closely associated with synaptic degeneration and this correlates well with tau pathology in 20 tauopathies interestingly historic observations in hamsters and squirrels show that when they enter into hibernation they also display tau pathology and synaptic loss pathologists have pointed to these similarities however there is an important difference synaptic loss is progressive in dementia but reversible in hibernating animals capitalizing on recent technological advancements i will unravel the mechanisms of this remarkable yet understudied process of synaptic remodeling in hibernation and then use the pathways that reverse synapse loss in hamsters to counteract tauinduced synaptic decline in models of dementia we will achieve these goals by first defining and studying the molecular and cellular drivers of synaptic remodeling during cycles of hibernation this is based on innovative spatial transcriptomic and synaptic proteome analyses in hamster brains we will then identify the human homologues of the hamster genes that reverse synaptic loss following hibernation and use a selection strategy in xenotransplanted human neurons and functional assays on customdesigned multielectrode arrays to isolate genes rescuing tauinduced neurodegeneration this approach is bold but feasible my lab has a record of accomplishment in synaptic and neurodegeneration research and we already have strong preliminary work implicating specific presynaptic pathways in the types of taudependent synaptic remodeling that we will study here the gain is that we will uncover the mechanisms of a remarkable process of synaptic resilience and apply this to rescue the synaptic loss in neurodegeneration this project will define a conceptually new and unexplored class of therapeutic targets to tackle tauinduced neuronal decline |
ecoloop | ecoloop project develops and demonstrates a set of solutions to optimise the combination of different energy distributed sources biogas biomass agripv geothermal meeting the local needs for electricity heating cooling transport and waste and land management in rural areas fostering regional development and creating benefits for farmers and foresters the project solutions will focus on promoting the reduction of carbon footprint in rural areas by means of the higher penetration of distributed renewable energy sources selfconsumption and an optimal agriculturalforest waste management while creating positive effects in biodiversity and soil health and reducing the risk on groundwater contamination following this approach ecoloop objectives areto optimise the production of biogas from agriculture and forestry wastes in situ to combine in an efficient and sustainable way different distributed renewable energy sources biogas biomass agripv geothermal meeting the local needs for electricity heating cooling transport and waste and land management in rural areasto develop innovative renewablebased agricultural protocols and advance bioproducts to increase sustainability and circularity while creating positive effects on biodiversity and soil health and groundwater pollutionto foster regional development in rural areasecoloop project will move towards a circular economy in rural areas focusing on agriculture and forestry sectors contributing to job creation gender equality biodiversity and climate resilience and adaptation all the benefits provided by ecoloop solutions will be demonstrated in 4 pilot sites in spain estonia bulgaria and slovenia involving different forest and agriculture natural conditions climate soils size and types of crops trees management techniques degree of mechanisation geographic location and socioeconomic factors and considering the interaction of different types of energy sources |
effective codelivery of therapeutic peptides and intestinal permeation enhancers using a double pickering emulsion oral delivery system | therapeutic peptides tps are one of the fastest growing classes of therapeutics with clinical applications in severe andor chronic diseases like cancer therapy hormonal or immune disorders and infectious or metabolic diseases to date most tps can only be administered by invasive injection which greatly influences treatment costs as well as patient compliance and wellbeing as eg diabetic patients rely on regular insulin injections oral delivery of tps poses a convenient alternative to circumvent these problems but it is highly challenged by i the harsh gastric environment detrimental to tps and ii the poor permeability of the intestinal epithelium to tps to tackle these problems i propose a novel oral delivery system for tps based on a unique gastric stable pickering double emulsion which is able to i protect tps from degradation in the gastric environment and ii codeliver hydrophilic tps and hydrophobic permeation enhancers pes to the absorption site the intestinal epithelium surface simultaneous codelivery of tps and pes is crucial but not often achieved as key deliverables orapickering will establish pickering double emulsions for the encapsulation of hydrophilic tps and hydrophobic pes explore their stability under gastric conditions and confirm their efficacy and safety for intestinal tp delivery in vitro and in vivo to implement orapickering i will join forces with prof nielsen from ucph combining my background in material and interface sciences with her expertise in tp delivery and intestinal permeation models and mechanisms i consider this the ideal environment for my further career development to learn relevant techniques for drug delivery and gain further experiences to emerge as an independent group leader in summary orapickering provides a novel avenue for oral tp delivery and thereby contributes to a more facile safe and costeffective administration of tps in the future |
clinical validation of the first implantable sensor system for wireless detection of stent occlusion restenosis | globally over 237 million people suffer from peripheral artery disease pad an abnormal narrowing of the arteries the implantation of stents spiral wire protheses is the firstline therapy for pad with 35m stents implanted worldwide every year restenosis the gradual reclogging of the blood vessel after stent implantation is a major problem leading to high morbidity and mortality which occurs within 6 years after implantation in 23 of all cases and is often detected when it is too late more frequent surveillance of pad patients to avoid unnecessary amputations and death is an unmet clinical challenge vesselsens is developing the stentguard a smart therapeutic monitoring device that enables rapid low cost early diagnosis of restenosis noninvasively and reliably this device allows stent monitoring at high frequencies with low cost by nonspecialist medical practitioners solving the problem of unchecked disease progression and saving the eu economy over 1bn year |
avifauna in archaeoecological networks | we love birds but probably do not worry enough about our relationship to them across the world we are threatening their critical ecosystem functions including birds positive impact on our wellbeing and poultry has become our favourite meat yet industrialscale breeding has consequences for human and bird health arguably this lack of concern is due to our ignorance of the deep historical roots of these relationships our interaction with birds for their plumage eggs meat song or spirit extends back to prehistory at the same time avifauna responded to climate shifts and to our modifications of the landscape this has created a tangled archaeological record which makes understanding birdhuman relationships all but impossible building upon and moving beyond my expertise in biomolecular archaeology aviarch will explore from a birds eye view the transition to agriculture in epipalaeolithicneolithic southwest asia and the emergence of urban life and trade routes in bronze age crete aviarch will reveal the variety of birds in past human systems by using new techniques for the identification of avifauna integrating zooarchaeology palaeoproteomics and ai my sites have been carefully chosen to target biodiversity hotspots with a rich archaeological record intersecting socioecological changes of humanbird relationships we will combine ecological morphological and behavioural traits for each bird to produce the most refined exploration of humanavian relationships yet attempted in archaeology using network analysis and underpinned by multispecies theory aviarchs archaeoecological models will discover how environmental shifts affected people and anthropogenic and climatedriven changes affected birdsby transforming the ways in which past birdhuman interactions are studied aviarch promises to improve human adaptivity avian conservation strategies and make us worry and marvel about these beautiful creatures a little more |
exploiting the multifunctional properties of polyphenols from wastes to high value products | phenocycles is addressing the environmental concern derived from agroindustrial wastes proposing their exploitation for obtaining important bioactive molecules polyphenolic compounds pp to be utilized for different purposes with a typical circular economy approach phenocycles aims at exploring innovative uses of pp and at validating methods for their extraction with a green chemistry approach pp extracted from agroindustrial wastes grape apple berry pomaces and herbs with therapeutic value will be purifiedfractionated with pilotscale nanoultrafiltration membranes to recover different pp fractions to be employed in four distinct sectors human health synthesis of substances for photodynamic therapy pdt and drug delivery dd development of innovative phytocarrier systems formulation of pp loaded micronanoscale systems development of new food supplements nutraceutics and hypoallergenic cosmetics plant production ppbased nanomaterials for plant protection against soilborne pests to increase plant resistance to stresses impacting on plantorganisms trophic interactions environment protection use of pp as sensitizer or intermediate in the synthesis of materials for water disinfection and advanced oxidation processes aops material sciences synthesis of metal based oxide nanostructures useful for photocatalytic applicationsto foster future exploitation of the innovations a thorough assessment of the stakeholders perception of their adoptability will be performed applying a participatory approach together with several innovative dissemination activities based on visual media the interdisciplinary exchanges planned in phenocycles are thus expected to increase the knowledge of researchers particularly young ones on the different methods utilized by the partners fostering further developments in medicine pharmacology crop protection food preservatives nutraceuticals cosmetics and other industrial applications |
reconstructing the pagan religion of tibet | buddhism was introduced to tibet in the 7th century ce and became the official national religion in the 8th a small percentage of tibetans are followers of a religion called bön which its adherents bönpos and buddhists alike consider to be the countrys indigenous faith bön came to acquire many buddhist features but retained a strand of more archaic traditions since there is no evidence that these traditions were actually called bön prior to the establishment of buddhism we refer to them collectively as tibetan pagan religion until now all we knew about this religion came from a small number of early mainly 811th c manuscripts from the silk road a small cache from southern tibet and some ritual narratives in the literature of reformed bön this situation changed dramatically in 2005 with the discovery of a large number of manuscripts constituting the ritual repertoire of a class of priests called leyu in the sinotibetan borderlands although facsimiles of some 35000 folios of these manuscripts have now been or are due shortly to be published in china other than the pi and members of his team no one has worked on them owing to difficulties of script language and the concepts conveyed preliminary investigations suggest that these texts contain genuinely archaic nonbuddhist rituals and narratives closely resembling those of the early sources that are already known using stateoftheart computational humanities tools such as handwritten text recognition and natural language processing in conjuction with the methods of philology comparative religion and anthropology pagantibet proposes to undertake a systematic study of the leyu manuscripts producing a searchable database of the entire corpus an annotated catalogue of its contents as well as translations and extended summaries of a selection of its works to provide the firstever reconstruction of tibetan pagan religion |
mathematical models for coral reefs towards an interdisciplinary and conservationfocused research | coral reefs are one of the most biologically diverse ecosystems on earth but their regression has largely increased in the last decades due to local human pressures and global warming this project aims to use numerical models and simulations to expand our understanding of coral reefs dynamics and improve marine conservation strategies i will follow an interdisciplinary approach using complex systems and nonlinear physics techniques combined with ecological knowledge and field data of coral reef systems my results will be the foundation to study a large variety of open questions in coral reef science using an innovative and groundbreaking point of view in this project i will focus on two applications of the models i the study of the underlying mechanisms causing the emergence of halolike patterns around reef islands grazing halos and ii the construction of a protocol to optimize and reduce costs in coral restoration programs i expect my results to have a high impact on the scientific community and contribute to making better and more informed decisions about the sustainable management of coastal zones in line with the new eu biodiversity strategy for 2030 a comprehensive ambitious longterm plan for protecting nature and reversing the degradation of ecosystems aiming to put europes biodiversity on a path to recovery by 2030 with benefits for people the climate and the planet |
dissecting the role of sperm transcriptome dynamics in intergenerational inheritance through native rna nanopore sequencing | mammalian sperm rna is increasingly recognized as an additional source of paternal hereditary information beyond dna environmental inputs such as diet and stress can reshape the sperm rna signature and induce offspring phenotypes that relate to paternal environmental stressors however how when and to what extent sperm rna populations change and what is the role that rna modifications and other posttranscriptional regulatory layers play in shaping sperm rna dynamics remains poorly understood here we propose to characterize the dynamics of rna populations during sperm formation and maturation using native rna nanopore sequencing this technology is suited to provide an integrative and comprehensive view of the transcriptome epitranscriptome degradation patterns and tailing dynamics simultaneously and with single molecule resolution we will establish novel library preparation methods that can capture the full sperm epitranscriptome and will capitalize on our recently developed algorithms to map and quantify rna modifications in individual rna molecules we will then apply these methods to reveal how paternal dietary exposures affect sperm rna populations and the metabolic phenotypes of their offspring and test whether the novel identified rna candidates can transmit dietinduced paternal phenotypes to the subsequent generation finally we propose to expand our previous work on direct rna multiplexing to establish single cell direct rna nanopore sequencing to characterize the diversity and heterogeneity of the sperm rna epitranscriptome at an unprecedented single cell and single molecule resolution |
derisking the drug discovery process of oncology and metabolic diseases | excellence vitala technologies brings together organonchip ooc hyperpolarized magnetic resonance spectroscopic imaging hp mrsi and advanced data analysis tools to provide a patented and revolutionary test for the monitoring of the efficacy in treatment of a new drug moving through the metabolic pathways of a cell this new methodology provides the opportunity to set preclinical drug testing strategies that are more effective faster cheaper and reduce animal use the information obtained by this novel methodology will improve the future steps for drug candidates in advanced preclinical and clinical stages vitalas analysis allows defining and executing on preclinical testing strategies increasing the speed of the drug discovery process and reducing its costsimpact an increased accuracy in the early stages of the drug screening process will allow discarding inadequate pharmaceutical candidates before those reach the animal testing stage reducing the number of animals used in the whole preclinical process moreover our objective is to derisk and revolutionise the entire drug discovery process decreasing the direct and indirect costs associated with the preclinical drug discovery pipeline with our realtime nondestructive highly sensitive technology vitalas impact will expand to later phases of drug discovery by preventing invitro and in vivo as well as human testing of drugs that in the absence of translatable models could have been deemed appropriate to proceed to later clinical trial stagesimplementation and team vitala is formed by a management team of professionals with complementary backgrounds in the fields of microfluidics imaging technologies and business administration vitala has already filled a pct patent application and successfully completed an fto which gives our technology a green light to be exploited both in the eu and the usa with short and long term strategies in place |
waste heat to energy | to cope with the growing global energy consumption and sustainable development scenarios waste heat recovery is an efficient green and economic solution to help highly demanding industries save valuable energyhowever while low grade waste heat 100 constitutes the largest source of heat with an annual 3700mtoe corresponding to 63 of the total recoverable heat it has not been widely exploited yet due to technical and economical difficulties only valorisation of high and medium grade in the form of electricity is largely deployed at industrial scalein the wh2e project sweetch energy is proposing an innovative way to convert low grade waste heat into electric power to do so two major steps will be necessary the conversion of temperature gradient into salinity gradient using thermosensible ionic liquids coupled with an osmotic engine inod to generate electric power as final output the inod ionic nano osmotic diffusion technology developped by sweetch energy is based on the most advanced nanotechnologies and specific membrane designat the end of the project a testing phase in partnership with an international industrial corporation will allow to reach a trl6 and secure the market readiness sweetch energy is targeting first the industrial sector and ambitions to become a global leader in the decarbonized electricity sector the project is supported by veolia and solvay |
multifunctional multimaterial magnetic components and structures for electrification | electric machines and drives including various types of electric motors play an everincreasing role in the way of making europe the first climate neutral continent in the world in order to achieve a breakthrough in the field of energy efficient electric motors novel approaches are needed high performance sustainable materials and multimaterial manufacturing technologies suitable for complex geometrics and capabilities to design and simulate structures and components based on those the ambitious goal of multimag is to develop novel design tools high performance materials and multimaterial additive manufacturing mmam processes hence to manufacture ready assembled lightweight components for electric machines and leading to better performing machines improved energy efficiency and shorter lead times after use the components can be dismantled and the materials recycled effectively multimag takes the full advantage of multimaterial additive manufacturing stacked rotor and stator structures combining dissimilar magnetic and electric insulating materials are developed manufactured and validated to ensure mechanical thermal electrical and magnetic performance internal structures enabling more efficient cooling are studied and designed achieving ambitious objectives of multimag requires a holistic approach and innovations in all sectors namely in design materials manufacturing use and endoflife each of these vital areas are addressed by multimag activities we will develop a framework and specific toolbox for addressing complex design challenges which are multimaterial multifunctional and multiphysics evaluation and development of matching material properties enabling to join dissimilar materials using am processes is one of the key focuses of multimag multimag approach requires also mmam processes to be developed further as well as recycling of rees |
euafrica research infrastructure alliance to foster infectious disease research knowledge sharing and innovation | the rafiki consortium will support capacity building for early drug discovery in africa with a focus on infectious diseases eg malaria tuberculosis subsaharan africa is disproportionately burdened by such diseases yet lacks a critical mass of appropriately skilled scientists and access to general infrastructure enabling technology platforms and expertise for drug discovery research rafiki will leverage existing collaborations within the consortium to build the knowledge and technical capacities of research institutions across africa rafiki will establish regional training hubs in south east and west africa to support local capacityskillset building for earlymidcareer researchers via bidirectional scientific training visits mentorships regional inperson workshops and online training courses to establish the requisite infrastructure for future drug discovery ri knowledge and procedures will be shared for compound library curation at partner institutions ie workflows open database creation library sharing capabilities and data management capacities will be bolstered using the collaborative drug discovery cdd vault to secure funding beyond the project lifetime the consortium will liaise with relevant industrial actors and potential publicprivate funders |
avodes biotechnological menstrual product for candidiasis prevention | 372 million women globally have a silent torturer recurrent vulvovaginal candidiasis vvc which affects 3 out of 4 women at some point in their lives despite therapeutic advances vvc remains a common problem worldwide affecting all strata of society and being the second largest gynaecological infection if it is left untreated many complications have been appointed as its consequence such as infertility subsequent preterm delivery suppression of the immune system pelvic inflammatory disease ectopic pregnancy pelvic abscess menstrual disorders and miscarriageavodes has developed an innovative medical device for menstruation a patented anatomically shaped moist sponge made of completely natural biodegradable materials biodegradable within 1 month it protects innate defence mechanisms of vaginal microflora during most vulnerable period menstruation studies have shown that fluctuating hormones and the resulting imbalance of vaginal flora cause an increased risk of a yeast infection every month unique avodes biotechnological solution preserves womens natural vaginal microbiota in the same time selectively inhibiting growth of pathogenic microorganisms it reduces risk of vulvovaginal candidiasis vvc by 85 thus effectively preventing the disease avodes is the only medical product designed to prevent infection rather than deal with the consequences avodes effectively disrupts the vicious cycle of microbiota disbalance infection antibioticfungicidal treatment microbiota disbalance and offers breakthrough solution which protects womens health and the environment women tech eu programme would support company in upgrading the business model business and marketing plan market validation and would help to find partners clinical manufacturing and commercial as well as to prepare funding strategy successful project implementation will provide much needed tailwind to our company to bring the product to the market |
aquaponics from wastewater reclamation | aware sets out to increase capacity to produce fish for human consumption at km 0 in every european city with no impact on natural habitats no dependence from natural freshwater availability and high resiliency to climate changethis goal could be met by farming fish locally using reclaimed water europe lacks the regulatory and policy framework to allow such a value chain to take root due also to the absence of compelling scientific evidence of safety quality economic feasibility and social acceptabilitywith aware we want to remove the barriers preventing reclaimed water aquaculture from becoming a european reality we will demonstrate seamless integration of our solutions in an aquaponic recirculation system ras with iot monitoring and automation technologies to improve its operation and overall sustainability metrics we will create the first european case study for reclaimed water aquaponics in the town of fasano puglia italy where we will leverage the results of a preexisting h2020 project on advanced wastewater treatment with the case study we willdemonstrate technical solutions for efficient and sustainable aquaponics from reclaimed wastewaterincrease the circularity of wastewater as freshwater resource to be exploited where it is generatedcreate a new farmtofork value chain contributing to european economic growth and to urban km 0 farminglay the ground for a new regulatory and policy framework in support of european aquaculturethe project will go as far as conducting human intervention ie feeding tests on a panel of volunteers to obtain evidence of safety and quality of the produced food in parallel it will develop a sustainable business model and strategy for the for the future upscaling of the pilot solution including its application to other european communities and in international development projects our consortium includes a large network one extraeuropean partner and one international organisation |
emergence in quantum materials from relativistic quantum criticality to nonfermi liquids and unconventional superconductivity | understanding and controlling novel states of matter is at the heart of condensed matter research in modern quantum materials we find a rich resource of extraordinary states which emerge from the complex interplay of quantum effects and manybody physics they pose the fundamental challenge of describing an interacting system with many constituents in the quantum realm and hold the key for future quantum technologya major common trait behind the complex phase diagrams of many correlated quantum materials evades a description with conventional manybody approaches a strange metal phase that exhibits non fermi liquid behaviour nearby quantum phase transitions and superconductivity quantemerge opens a new way to comprehend such non fermi liquids and their intertwined phases by establishing a connection to relativistic quantum criticality and moir materials relativistic quantum criticality arises at quantum phase transitions with emergent lorentz symmetry and can be viewed as a minimal model for non fermi liquid behaviour while moir materials constitute a new materials platform with unprecedented experimental control over such transitions their connection allows us to tune into the strongly correlated quantum regime from a controlled starting point in both experiment and theoryexploiting different tuning parameters such as interaction symmetry temperature and density we develop a comprehensive picture of emergent phases in a quantum critical regime with cuttingedge renormalisation group methods we characterise novel types of quantum phase transitions in this setup and determine the corresponding quantum critical behaviour we calculate thermodynamic and transport properties and study the competition of non fermi liquid and superconductivity our theoretical insights will provide an improved understanding of the remarkable quantumdominated phase structure that emerges in correlated quantum materials and pave the way for future materials design |
how to evolve without centromeres meiotic recombination dynamics in holocentric plants | centromeres strongly affect genomic architecture and meiotic recombination distribution and also play a key role in constraining karyotype evolution the recombination landscape is also heavily influenced by chromosome number and structure ie karyotypes as at least one crossover per chromosome and rarely more than three occurs in most species making chromosome number the primary driver of recombination frequency in addition centromeres inhibit recombination and therefore crossovers tend to occur mostly at chromosome endshowever several unrelated eukaryotic lineages do not have centromeres or at least not conventional ones such is the case for plants with holocentric chromosomes where hundreds of small centromerelike units are evenly distributed across the length of the chromosome notably holocentricity has evolved repeatedly across the tree of life and at least four times during plant evolutionholocentric plant species offer a unique opportunity to study the plasticity of meiotic recombination control these species have lost typical centromeres making them ideal for investigating how the recombination landscape was reshaped after the transition to holocentricity moreover holocentricity unleashes changes in the karyotype offering the possibility to analyze the effects of chromosome breaks and fusions on recombination frequency and distributionthe holorecomb project aims are as followsianalyze how transitions to holocentricity affect meiotic recombination dynamics in different holocentric plant lineagesiiexplore the effect of chromosome breaks and fusions on crossover number and distributioniiiexamine whether the crossover regulation in holocentric plants acts in a similar manner as in monocentric onesunderstanding how holocentricity affects recombination dynamics will provide insights into important mechanistic aspects of meiosis with potential practical applications for crossover regulation in centromeric regions |
innovative organic fruit breeding and uses | the organic fruit sector is highly dependent on inputs particularly in terms of plant protection climate change is increasing impacts and risks to organic fruit production large market demand is expanding for organic fruits but the current commercial cultivars cvs range previously selected in high input paradigm are for most of them not adapted to organic production innobreed proposes to mobilise innovative solutions iss social innovations new ideotypes new methods for screening robust cvs and genitors with larger genetic bases for fostering organic fruit breeding these iss will be targeted and developed on participative multiactor and multitrait based approaches and then applied for evaluating underutilized fruit tree genetic resources ftgr prebreeding and advanced material innobreeds scope encompasses many rosaceous species but also citrus and grape innobreed aims to improve the whole fruit chain through the implementation of an organic variety testing network of actors it deals with iidentification and definition of current lockin in organic fruit farming systems ofsii codesigning new ideotypes fitting with local ofsiiiidentification of performant is already available ivdevelopment of new climate change iss but also for fruit quality pests and diseases tolerance low input fitness and robustness and their application by ftgr curatorsv iss validation process and implementation by several publicprivate casestudies in different regions for evaluating their efficiency and vichecking sustainability and consistency with actual regulations before being disseminated for maximizing is impacts on the value chaininnobreed is deeply connected with running initiatives programmes and resources involved in ofs organic fruit participative and classical breeding fostering ftgr uses by fruitchain scientists and stakeholders particular attention will be paid to embed the relevant stakeholders at national and european levels |
habenula molecular and functional organization in models of pathological emotional states | emotions guide humans and animals in the selection of behavioral strategies to optimize outcomes and promote wellbeing repeated or unexpected strong negative stimuli such as stressors impair the processing of emotions and lead to the development of mood disorders such as depression and anxiety understanding how individuals control their emotions and cope with stressful events has become a major clinical challenge for the development of new treatments this project aims to define the circuit mechanisms that control emotional regulation i will focus on a brain region key in emotional regulation namely the lateral habenula lhb over the past decades clinical and preclinical studies have identified the lhb as a major hub in the regulation of negative emotions and in the induction of mood disorders recent studies have highlighted that lateral hypothalamic lha excitatory inputs to the lhb drive negative emotions ie aversion and may play a role in depression however how the lhb integrates diverse types of inputs to promote negative emotions remains unknown the main hypothesis of the project is that the complex regulation of emotions is defined by a discrete organization of inputs to lhb that underlies maladaptive circuitspecific dysfunction in models of stress i will investigate here the molecular and functional properties of the lhb neurons based on their discrete inputs from the lha i will use a multidisciplinary approach combining cuttingedge spatial transcriptomics neuronal tracing and optogenetics to define for the first time the role of the molecularlydefined discrete lhalhb pathways in normal and diseaserelated behaviours this project will provide key insights about the regulation of mood by the lateral habenula and how the inputs from the lateral hypothalamus are key in the pathophysiology of depression and anxiety disorders |
healthy adaptation to pregnancy postpartum and parenthood | annually around 4 million european couples face lifechanging transitions as they move from pregnancy to postpartum and early parenthood these transitions require adaptation to changes and challenges for women and their partners obesity and mental health problems are the two most common and interconnected complications with significant implications for overall health and wellbeing of future families and high costs for society the hap3 network builds capacity for tackling these challenges to meet the needs of women and their families and assist care providers in their pivotal roles integrative familyinclusive stateoftheart monitoring and coaching modules are neededresearch objectives of hap3 are 1 to examine risk and protective factors and mechanisms of obesity and mental health problems 2 to cocreate an online hap3 intervention consisting of a family app and dashboard for care providers 3 to test the feasibility of the family app and dashboard 4 to identify implementation factors and to develop implementation strategies for the implementation of the hap3 interventionhap3 deliverables are a list of critical health indicators related to prevention of obesity a validated prediction model for early childhood obesity an operational cocreated hap3 intervention infographics for care providers including strategies for the reach of vulnerable groups a report on policylevel barriers and facilitators for the implementation of the hap3 intervention a toolbox for the future implementation of the hap3 intervention the hap3 training objective is to educate future perinatal care innovators in knowledge research expertise and transferable skills needed to lead improvements in realworld care settings |
bone marrowonchip as smart sensor of lung cancer relapse | in the past 40 years the overall survival rate for people affected by tumors has doubled with about 50 of patients now surviving their disease for 10 years or more nonetheless some cancers eg lung cancer still have poor survival rate a major cause of lung cancer mortality is represented by disease relapse occuring when few of the original cancer cells survive the initial treatment and causing primary tumor recurrence currently no options are available to predict the risk of lung cancer relapse which is only diagnosed late based on radiological evidence hence the ability to early detect lung cancer relapse represents an urgent and unmet need since a fast and tailored treatment could dramatically increase patients survival ratebuonmarrow lays on the groundbreaking hypothesis supported by our consortium preliminary clinical evidence that bone marrow mesenchymal stromal cells bmmsc may be educated upon cancer mediators exposure and acquire a longterm memorylike response which is amplified when exposed to a secondary tumor owing to breakthrough technologies available in the consortium organonchip innovative optical sensors and biological modeling of the bone marrow niche buonmarrow partners will develop an in vitro miniaturized bone marrow device able to harness the amplified bmmsc response generated by liquid biopsy of lung cancer patients thus acting as a biological sensor for the early detection of relapse a combination of retrospective and prospective clinical studies respectively will allow to calibrate and validate such sensor delivering an unprecedented tool to assist the decisionmaking process on lung cancer patientswe expect to significantly improve oncological treatments building on a personalized medicine approach to increased patient survival and wellbeing and thereby deeply impacting on eus socioeconomic environment |
innovative polymers from tomato cutin esters monomers | the production of cutinbased polymers is currently made from acid monomers that result in conventional plastics these cutinbased plastics do not have the 3d structure of the natural cutin limiting its application polymatos project aims to develop an isolation and fractionation integrated highpressure process to obtain cutin esters monomers from tomato pomace tp to be applied as building blocks of innovative biopolymers the present proposal relates with a novel approach to the production of polyesters by addressing a key challenge in the current biopolymer research the maintenance of the flexible 3d polymeric structure characteristic of cutin in a cutinlike polyester using ester monomers instead of acid monomers this approach can efficiently increase hydrophilicity and degradability plus modulate the mechanical chemical and biological properties of polyesters the research will focus on evaluating the process conditions that would achieve cutin yields and highly functionalised building blocks in continuous microreactors polymatos has a strong multidisciplinary character since it links together biology biochemistry chemical engineering and material science to expand the application of tp to the production of an innovative polyester the proposed process will be a fundamental contribution to generating an additional revenue stream and reducing residues production in tomato processing due to the abundance of cutin the findings can be extended to other production activities benefiting the food industry and society polymatos will allow me to develop my leadership skills through innovation the project will be carried out by the experienced researcher dr aguiar at the bioeconomy research institute universidad de valladolid under the mentorship of prof cocero two secondments one at universidad de mlaga and the other one at cellmat technologies will be carried out to strengthen knowledge in polymerisation reactions and polymers characterisation |
intelligent advanced photonics tools for remote andor onsite monitoring of cultural heritage monuments and artefacts | iphotocult aims to design develop demonstrate and validate innovative and intelligent solutions that will allow for noninvasive and safe ways to inspect document diagnose and monitor cultural heritage ch so as to ensure efficient adaptation of sustainable management plans these solutions comprise a a unique suite of advanced diagnostic and monitoring tools along with methodologies for their effective and optimum use combined with b an intelligent data processing visualization and prediction software services platform for the remote andor onsite monitoring of ch buildings monuments and artefacts impacted by a wide variety of environmental and anthropogenic threats iphotocult contributes significantly to the preservation of ch by adding verifiable dimensions to preservation strategies the iphotocult solutions will enable and empower ch community to better assess ch in a costeffective efficient reliable userfriendly and safe manner these solutions will revolutionize the capabilities of endusers to diagnose and continually monitor the condition of materials constituting ch including those used in their restoration iphotocult interdisciplinary approach involving many different stakeholders and ch pilots across europe will serve as usecases for demonstration testing and validation of the iphotocult solutions delivered and applied in the form of demonstrators the outcomes to a variety of ch pilots will provide crucial insights and enable the optimization of the tools and methodologies to help in the decisionmaking and serve for replication to europes ch in many in real settingsultimately iphotocult main goal is to contribute to the sustainable management of europes ch by leveraging advanced photonics technologies and intelligent software to contribute to the decisionmaking process for its preservation iphotocult aims to develop a comprehensive costeffective and scalable solution that can be deployed across europe and beyond |
infrared nanospectroscopy to understand and combat alzheimers disease | neurodegenerative diseases are a ticking timebomb for health care systems because they are careintensive and will soon become much more widespread due to increased life expectancy their most common form is alzheimers disease ad in which the amyloid a peptide aggregates to amyloid fibers that accumulate in plaques in the human brain we will study unresolved key aspects of ad in order to understand and eventually combat the disease the objectives are1 to map the biochemical composition of plaques with unprecedented spatial resolution in order to understand the role of lipids in plaque organization and development possibly leading to a biochemistrybased classification of these brain lesions2 to characterize coaggregates of a with other amyloidogenic polypeptides which may link different diseases and improve diagnosis3 to improve antiamyloid peptides for a possible new ad treatment by characterizing and optimizing their interaction with a and4 to establish isotopeedited nanoscale infrared ir imaging as a versatile tool to characterize chemically similar components of mixtureswe will exploit the advantages of novel approaches in ir spectroscopy to move the field forward in areas that are difficult for more common methods ir nanospectroscopy with 20 nm spatial resolution will be used throughout and will be combined for the a studies with isotopeedition and with fourier transform ir spectroscopy the supervisor is a wellknow expert in biological ir spectroscopy and has recently established all approaches in his work i as the researcher will be trained in advanced ir spectroscopy as well as in transferable skills incl leadership and in pedagogics the expertise in ir nanospectroscopy will particularly promote my career because the technique is about to revolutionize chemical imaging and has many applications in basic and applied science for the same reason also the eu will benefit from additional experts in this technique |
engineering of superfluorescent nanocrystal solids | the time is right for lightemitting colloidal nanocrystals to meet the demands of the second quantum revolution the cooperative emission superfluorescence was recently observed in the micronsized solids of colloidal lead halide perovskite nanocrystals offering a path to lowcost solutionprocessed sources of bright and coherent light superfluorescence characterized by highintensity and ultrashort bursts of indistinguishable photons makes nanocrystal solids desired targets for photonics and quantum information applications however the exact origin of the superfluorescence is debated and the rules of nanomaterial design for ondemand cooperativity are unknownprometheus tackles these issues by combining nanochemistry with spectroscopy and tools of quantum optics the projects approach consists of 1 synthesis and judicious selection of emissive metal halide nanocrystals with minimal exciton energy inhomogeneity 2 accelerated selfassembly of nanocrystals into binary solids with a tunable fraction of emitters 3 cryogenic microphotoluminescence spectroscopy at the level of individual nanocrystal solids the control of the coupling between emissive nanocrystals is achieved by diluting opticallydense nanocrystal solids with a second transparent nanocrystal component measurements of spectroscopic observables coherence and photon statistics on single nanocrystal solids are used to dissect the roots and properties of cooperative emissionthe project introduces a concept of lightcoupled nanocrystal solids where lightmatter interactions are engineered through structure and composition this concept goes beyond metal halides and applies to emissive nanocrystals of any shape opening a class of colloidal nanomaterials with light emission controllable between singleparticle and manybody regimes such materials are expected to expand applications of emissive nanocrystals in quantum technologies and yield new uses in materials science |
multiscale hierarchical imaging of the spiraled structure of narwhal tusk | narwhals are mysterious animals that have fascinated humankind since ancient times they are known for their unique spiralled tusks which made people believe in the existence of unicorns for centuries the up to 3 m long straight tusk displayed by males always has a lefthand spiral macrostructure making it unique in the animal kingdom very little is known about these fascinating animals and the reason origin and biological structure of their tusk is a great question mark among marine biologists and biomaterial scientists in the proposed project we will aim to reveal the hierarchical structure and biomineral characteristics of this unique biological material their tusk for that purpose we will employ a combination of recently developed 3d xray imaging techniques in a hierarchical approach studying their nano micro and macrostructure with xray computed tomography xray diffraction and xray small angle xray scattering novel imaging techniques using synchrotron radiation like tensor tomography will reveal the structural organization and anisotropy of the tusk building blocks and diffraction computed tomography will provide very valuable information about the biomineral phase in the tusk and teeth the multilength scale approach explained in this project will be a pioneer in the field and we expect to establish a new methodology for a more complete structural characterization of biological and composite materials all that will be implemented and developed in the 24 months of the project which compiles 4 experiments in largescale synchrotron facilities data analysis strategies development and the establishment of a complete multiscale model of the narwhal tusk biological structure |
how genetic constraint and selection drive colour diversification reconstructing the evolutionary history of sexual dichromatism in island endemic lizards | how genetic architecture and selection jointly contribute to evolution is central to understanding the striking diversity of colours and patterns in nature yet major questions remain do novel colour variants appear gradually or in jumps can evolution of sexual signals proceed independently of colours used for crypsis can evolution modify male colouration independently of the colour of females and vice versa answering these questions requires the integration of highly multivariate data on colouration and ecological data as well as information about the underlying genetic relatedness between populations and lineages in particular rapid diversification of coloration between lineages of the same species can put the role of genetic constraint and selection in evolution to the test this project will be novel in studying these factors simultaneously across an extraordinary radiation balearic wall lizards podarcis pityusensis and podarcis lilfordi these lizards exhibit a striking variation in colouration between lineages isolated on more than forty islands in the balearic islands spain in this project i will i reveal the evolutionary history of balearic wall lizards ii establish if genetic constraints bias evolutionary change by reconstructing evolutionary transitions in body colouration between males and females ie sexual dichromatism and iii put to the test the role of sexual and natural selection for evolutionary change in male and female colouration this will offer genuine insights into the origin and evolution of colour diversity and help to resolve how the diversification of colouration is shaped by genetic constraints and sexual and natural selection complementary this project will provide a wealth of information eg molecular morphological ecological about two endemic species currently facing a decreasing population trend |
a native mass spectrometry systemic view of cellular structural biology | protein structure and consequently function is influenced by the cellular content the array of splice variants posttranslational modifications cleavages and the ability to bind cofactors and drugs is governed by the surrounding cellular milieu this is determined by internal and external cues such as cell type developmental stage stress conditions disease and aging which give rise to an ensemble of distinct protein entities to study this diversity there is a need for methods that enable structural studies under closetolife conditions maintaining the natural environment and biological diversity features that are often lost during biochemical purifications our recent discovery that native ms can be conducted within crude cellular lysates directms while preserving the biological context offers many new experimental avenues for investigating protein interactions and diversity here we propose to take native ms to a new dimension enabling a systemic view of cellular structure biology by endorsing technological computational and methodological developments to do this we will i establish a platform for highthroughput screening of protein interactions ii unravel protein interactions in human and other eukaryotic cells iii develop a method for wholeorgan directms analysis unravelling the tissuespecific proteoform landscape each of our three independent but complementary aims involves a different biological system going from bacteria through human cells to intact tissues together these advances in conjunction with the highresolution and sensitivity afforded by current mass spectrometers has the potential to advance a plethora of fields including cell biology pharmacology and biotechnology overall we anticipate this project will promote the integration of directms into the cellular structural biology toolkit providing valuable insights not attained by other structural biology methods or artificial intelligence algorithms |
european tidal energy pilot farm focused on industrial design environmental mitigation and sustainability | there is 10gw of predictable highvalue tidal stream energy potential in european waters with up to 100 gw of capacity globally this is an almost entirely unharnessed clean energy resource with just 13 mw currently deployed transitioning european market leading technologies from single deployments up to farm scale is the next milestone in harnessing this clean predictable secure domestic energy resource eurotides has been developed specifically to address the call topic by delivering a 96mw farm of four 24mw orbital tidal energy devices of the same series the farm will operate in full operational conditions for 15 years deploying in 2027 the eurotides consortium will work collaboratively to deliver six ambitious objectives and drive the sector forwards1derisking tidal energy technology development by delivering a 96mw pilot farm and three pilot farm system innovations reducing levelised cost of energy lcoe of orbitals floating tidal technology from 120mwh to 100mwh2increase bankability and insurability by providing 17520 hours of operational data displaying the production of 50gwh and verification of key technology metrics to internationally recognised methodologies reducing cost of capital from 1012 to 563increase availability of tidal stream by creating an efficient robust replicable and reliable operations and maintenance programme increasing availability to 954improve market confidence by developing industrial design and manufacturing processes increasing supply chain capacity from one device per annum to 80 devices per annum5increase knowledge of environmental impacts to ensure appropriate environmental protection and mitigation is in place enabling safe scalability to a 100gw global market6making performance reliability and behavior data collected from the demonstration publicly available accelerating scalability commercialisation and deployment of a 2gw project pipeline |
internal and international climateinduced migration gendered inequalities and governance understanding migration decisions exploring migration experiences | the world bank estimates that climate change will force 216 million people to leave their homes by 2050 using un data the australian think tank iep calculates that 12 billion people risk being displaced by 2050 because of ecological threats beyond alarmist projections of which we need to be wary and as a matter of fact we know little about the articulation of internal and international climateinduced migration because once those on the move cross borders they become labour migrants asylum seekers or undocumented migrants with climaterelated causes rendered invisible in the absence of any internationally recognized status for climate migrants it remains unclear what proportion of international migration flows are also caused at least partially by changes in peoples natural environments that relate to climate change importantly we know even less about the gendered inequalities that permeate these forms of mobility to fill this crucial gap genderedclimatemig explores climateinduced internal and international migration and their articulation from a gendered perspective and through an interdisciplinary comparative and participatory methodology this project will produce highly informative ethnographic casestudies in 3 middleincome countries and regional migration hubs mexico morocco and malaysia along with a multisited and gendersensitive enquiry into the current state of climate migration governance at international eg platform on disaster displacement and national levels exploring original national policy initiatives eg in norway peru and kenya the qualitative and participatory methodology of this research promises to lend unique insights into the decisionmaking processes trajectories and lives of climate migrants through a gendered lens genderedclimatemig will advance our understanding of the underresearched climatemigrationgender nexus while carving out more space for migrants voices |
fair to adapt to climate change | the fair2adapt is a multidisciplinary project geared towards transforming data into actionable knowledge to shape climate adaptation strategies by leveraging and collaborating with eosc we fully tap into the eoscs wide range of services the fair implementation framework catalogue of resources and align with the eosc interoperability framework we adopt fair digital objects fdos by using rocrate and nanopublications as key implementation tools we use semantic bridging strategies such as the iadopt framework and tailored fdo services to build a collaborative userfriendly fair and open data sharing framework rich case studies will codevelop fair supporting resources in alignment with the fairification framework and demonstrate the impact of fair and open data sharing on climate change adaptation and strategically support the eu missions objective of enhancing climate resilience in european regions and communities through transfer cases and collaboration with other initiatives fair2adapt extends its reach to additional contexts showcasing its scalability sustainability and applicability beyond the projects completion a significant aspect of the fair2adapt project is stakeholder engagement and capacitybuilding activities which will be instrumental in raising awareness and devising customised solutions by transforming data into flexible practical and resilient climate adaptation strategies fair2adapt constructs a scalable and extensible model for data sharing that can be adapted to multiple climate adaptation scenarios the impact of fair2adapt will span across scientific advancement economic resilience socialenvironmental wellbeing and responsive policy development fostering multidisciplinary cooperation enhancing trust in science and stimulating a climatesmart economy ultimately fair2adapt intends to build a more resilient inclusive and knowledgebased society capable of efficiently tackling the challenges of climate change |
the eye as a window to the brain | nocturne gmbh founded in 2018 is a spinoff from the charit universittsmedizin berlin germany developing software solutions to efficiently process retina image data for neurological applications at scale across devices using advanced aibased analysis the innovative and unique technology developed tackles one the current major challenges in healthcare the rapidly increasing burden of brain diseases with the increase of life expectancy and aging population neurological disorders are the leading cause of disability and the second leading cause of death worldwide the greatest unmet needs are better faster and more costeffective diagnostic and monitoring tools that could be widely available and have the potential to detect these diseases at the earliest stage in order to delay disability and provide each patient with a personalized treatmentto address this the team of nocturne identified two major opportunities the use of the retina as a window to the brain and an already established on the market hardware imaging technology costeffective widely available with no burden for the patient that can capture retinal images in less than 5 minuteswith its product nocturne addresses customers in pharmaceutical research academia and clinical care in germany alone more than 1 million patients suffer from relevant diseases like multiple sclerosis parkinsons disease and others we estimate the annual market volume in germany alone at 350 million in europe at 2 billion at market entry nocturne product is a cecertified local installable web service which accepts data from standard retinal imaging devices the data are then analyzed with nocturnes technology and a report is generated for the physician the pricing is based on a payperanalysis a model commonly used for example in radiologyour focus is by removing the technical barriers and by providing unique insights into the diseases to enable better disease management and patient care |
translating islam the european understanding of islam and the influence of dragoman translations on the interreligious dialogue between christians and muslims 17301750 | the project aims to bring to light the only planned venture financed by a european country to explore ottoman culture before the development of 19th century orientalism and colonialism through the analysis of the french translation of a highvalue group of 10 religiousthemed ottoman manuscripts i aim to contribute to the combat of todays islamophobic societal sentiments still largely conditioned by outdated christian stereotypes and generally unaware of peaceful christianmuslim relations documented in recent scientific studies by encouraging widespread societal reeducation initiatives designed to improve an objective and unprejudiced understanding of islam the body of texts selected from a collection of around 120 translations on various topics still completely unknown to the scientific community commissioned in 17301750 by the french government to dragomans the official interpreters of the embassy in istanbul and jeunes de langues dragoman apprentices and conserved at the parisian bibliothque nationale de france bnf since the first half of the 18th century will be the principal field of inquiry to examine whether to what extent and in what way dragoman translations contributed to the spread of such european perceptions of islam and eventually impacted the interreligious relations between christians and muslims |
creating actionable futures | the craft project will place the transition to climate neutrality at the heart of urban stakeholders we will support the mission board on climateneutral and smart cities and the h2020 lcgd122020 onestop platform in designing and deploying climate city contracts based on experiencebased knowledge from crafts 3 sandbox cities bologna prague and amsterdam and 70 reference cities engaged in testing and sharing knowledge together with cultural artistic and creative sectors property owners and tenants and citizens and communities we will deliver a climateneutral and smart cities guidance package neb edition featuring at least 160 collaborative local governance models tools examples or stories this will be supported by a nebinspired impact model that helps cities to harness the value of inclusiveness aesthetics and sustainability as understood within the local contexts of their city in their transformation towards climate neutrality in at least 80 local emblematic projects more than 30 european universities and schools of arts and design will be engaged in supporting their local cities with more than 100 students engaged in steam teams internships and local capacity building we will deliver at least 6 policy briefs informing european policy and programmes about the learnings of these activities and a storytelling campaign to cocreate positive and inclusive narratives towards climateneutral futures for with and by citizens and communities together we will create actionable climateneutral futures across europe by supporting the deployment of nebinspired collaborative local governance models leaving no one and no place behind |
process innovations for the mineral industry focusing on roasting and calcination kiln technologies and supported by novel pre and postprocessing | primrock addresses process efficiency through a multifaceted strategy addressing industrial processes from input to output supported by an ambitious digital framework and transversal supporting activities in particular advanced techniques for the preprocessing of the raw material will be deployed to enhance its efficiency according to the requirements of the process supplemented by simulations and decision support systems to increase the operational limits of flexibility in the feedstock domain additionally the process intensification component of the project will design develop and validate innovative and efficient processes as well as optimizing the existing ones the aim is to develop a portfolio of technologies to a higher resource efficiency and lower level of ghg emissions of extractive industries the project will focus on improving the resource efficiency of the calcination and roasting processes that are commonly used in the mineral and cement industriesto this end process simulations in collaboration with ai datadriven models will be utilized and a digital twin for each process will be developed finally waste reduction and reutilization strategies will be investigated targeting to the realtime processes adjustment capabilities to feedstock changes and tighter processing control solutions all these components will be supplemented by transversal supporting activities such as technoeconomic assessment lca standardization etc the primrock solutions will be demonstrated in 3 different aspire sectors namely minerals magnesite laterite cement limestone and nonferrous metals sphalerite chalcopyrite the consortium is composed of 7 smes along with 6 rtds 3 universities and 5 large enterprises working together to achieve over 30 resource efficiency enhancement in each usecase 770ktco2 averted productivity increase in the range 916 and more that 1360 new jobs by 2033 |
evidence management for continuous certification as a service in the cloud | cloudbased services have grown from basic computing services to complex ecosystems comprising virtual infrastructure business processes and application code these advanced services also increasingly leverage the usage of artificial intelligence including machine learning or natural language processing techniques raising the complexity even higher due to the cascade of dependencies among the different products and services the need arose to bring more agility to the certification process of cloudbased services eg using continuous monitoring and assessment as evidenced by references to it in the certifications of the eu cybersecurity act eu csa to transform the continuous assessment and certification concept into the complete realization of a certificationasaservice caas several challenges need to be solved 1 current proposed proofs of concepts for continuous monitoring lack interoperability at technology level 2 the adoption of cloud and edge computing and the incorporation of regulations on specific topics or domains such as ai put significant strain on companies to comply with a multitude of different security schemes 3 existing market fragmentation for continuous certification scope methodologies hinder transparency and accountability in the provision of european cloud services 4smart tools and models need to be adopted to ease the agile application and implementation of the caas concept reducing complexity in the whole cloud certification value chain easing the adoption of caas by the different stakeholders to overcome these challenges the design and implementation of the emerald caas solution leverages the h2020 project medinas outcomes and advances them to trl 7 in the emerald core two pocs will be provided one for composite certification and one for mapping requirements to upcoming ai certification schemes emerald will pave the road towards caas for continuous certification of harmonized cybersecurity schemes |
vulnerability exposure analysis for javascript | the javascript programming language together with the nodejs framework constitute the foundation of modern webbased software an essential part of this platform is the npm registry that contains millions of freely available thirdparty software libraries that provide common functionality this massive reuse of libraries is essential to the productivity of software developers however the dependence on other peoples libraries opens the door to security vulnerabilities that may have severe consequences to the applications and end users when new vulnerabilities are discovered it is thus crucial that the programmers are informed existing tools only tell whether a program depends on libraries with vulnerabilities but without precise information about how the vulnerable library code is being used which causes an overwhelming amount of false positives and makes it extremely difficult for the programmers to investigate the possible consequences of the vulnerabilitiesthe erc project paw has delivered a range of novel program analysis techniques most notably one that has the potential to alleviate this problem the analysis tool jam is capable of automatically analyzing a given javascript program and tell exactly which parts of the libraries are being used and where they are used thereby enabling the programmers to make fast and correct decisions about how their programs are exposed to vulnerabilities and how to update their programs accordingly to prevent security incidents the proposed project pawjam aims to explore the commercial and innovative aspects of this program analysis tool by further developing the prototype implementation into a commercial product performing more extensive evaluations of its effectiveness and engaging with potential users and industry partners |
concentrations and fine properties of pdeconstrained measures | the interaction between microscopic and macroscopic quantities lies at the heart of fascinating problems in the modern theory of nonlinear pdes this phenomenon modeled by weak forms of convergence entails the formation of oscillations concentrations and fine geometric patterns ubiquitous in geometric physical and materials science models confine will investigate the nature of concentrations and fine geometries arising from longstanding conjectures and novel questions of the calculus of variations the goals comprise two themes theme i examines the qualitative and quantitative nature of pdeconstrained concentrations building upon results recently pioneered by the pi its purpose is to prove a novel interpretation of bouchittes vanishing mass conjecture and novel compensated integrability results with profound implications for the compensated compactness theory theme ii investigates the fine properties of pdeconstrained measures from three different perspectives via potential and measure theory methods it will attempt to produce substantial advances towards solving the sigmafiniteness conjecture in bd spaces it will also investigate the structure integral of varifolds with bounded firstvariation the goal is to prove that these measuretheoretic generalizations of surfaces possess an underlying bvlike structure lastly theme ii conjectures a complementary result to the groundbreaking de philippisrindler theorem which asserts that the regular part of an afree measure is essentially unconstrained this set of problems comprises significant theoretical obstacles at the forefront of the calculus of variations and geometric measure theory in this regard the proposed methodology gathers novel ideas oriented to overcome such paramount challenges consequently farreaching implications beyond the proposed objectives are expected in the development of new methods and applications in diverse fields of analysis |
breaking the resolution limit in twophoton microscopy using negative photochromism | multiphoton microscopy is a benchmark tool in biomedical research used for the fluorescence imaging in cellular environments this has important implications for disease diagnosis and the monitoring of therapy response in conventional twophoton microscopy the fluorescence intensity of the employed molecular probe is proportional to the square of the excitation light intensity implying that the fluorescence from the sample is confined around the focal point yielding good spatial resolution the spatial resolution can be dramatically improved by drawing on higherorder processes such as fourphoton absorption however its practical implementation imposes major technical challenges such as extreme laser intensities in the deep nir for this reason fourphoton microscopy has so far attracted academic interest onlythe present proposal addresses this issue and provides a multidisciplinary answer to the question can we develop a technique that offers spatial resolution of fourphoton microscopy but relies on twophoton absorption this would combine the upsides of twophoton microscopy low excitation energies provided by standard lasers at around 800 nm high penetration depth in tissue with the superior spatial resolution of fourphoton microscopy the result would be nothing less than a true paradigm shift in multiphoton microscopy the key to tackle this highly ambitious task lies in the design of molecules that combine two mechanistically entangled twophoton processes 4for2 for the generation of a fluorescence output this is possible by merging twophoton absorption twophoton fretinduced photoisomerization and negative photochromism purposefully designed switchable fluorophores that unify these photophysical assets will be developed and their performance will be critically validated in a multiangle spectroscopic workflow including the demonstration in applicationrelevant biological environments |
arrowhead flexible production value networks | the ambition for arrowhead fpvn project is doubling of the european industrial productivity by applying transformative autonomous and evolvable information interoperability for resilient and adaptive production value networks hence the arrowhead flexible production value network fpvn project will provide autonomous and evolvable interoperability of information through machineinterpretable content for fpvn stakeholders the resulting technology is projected to substantially impact manufacturing productivity and flexibilityautonomous and evolvable interoperability will be achieved through common project technology based on three pillars1 microservices paradigm2 utilization of major industrially accepted data models 3 automatic translation between the data modelsthe common technology will be validated and verified in 11 use cases covering the production value networks in the following industrial production domains semiconductor production automotive services aerospace services green energy conversion and process industry productionthe results are expected to considerably impact the efficiency of both local and global production value networks thanks to substantial cost and time reduction for setting up operating and managing the interactions within production value |
scalable and quantum resilient heterogeneous edge computing enabling trustworthy ai | smarty invokes a cloudedge continuum made from heterogeneous systems that protects dataintransit and datainprocess in order to offer a trustful fabric to run ai processes the securitization occurs by employing novel accelerators for quantum resilient communications confidential computing software defined perimeters and swarm formation offering multiple layers of security semantic programmability and graphmanagement open the door to draganddrop approaches in deploying services in a fast and reliable mannersmarty is proposed within the context of different key sectors in europe automotive fintech telco and industrial settings the technology proposed in smarty will be matured within the lifetime of the project and tested through five use cases smarty is supported by large european industry players and well as by 13 smes which will seek a visible platform to develop their products and gain visibility towards highgrowth smartys major suppliers and oems and reputable academic partners provide a great opportunity for these 13 smes to mature their technologies in a challenging but safe environment the results of smarty are applicable to different vertical sectors and can be transported to different use cases strong synergies with existing efforts in the area of edge computing european processors and trustworthy ai are envisioned and planned within smarty |
transport resilience against cyber and noncyber events to prevent network disruption | the transport network is among the socalled critical infrastructures cis which are essential to maintaining the vital functions of the single market while it is by nature a largescale interconnected and interdependent system to efficiently move people and goods its complexity also makes it more vulnerable in the event of a disruption and generates economic impact on a european scale due to the increasing crossborder interdependencies between services provided using critical infrastructures in these sectors an interruption in one ms may have implications in other ms or in the union as a whole in december 2022 council recommendation 2023c 2001 suggested giving priority to four of the eleven sectors mentioned in the cer directive including transport although transport is recognised as a key sector to be protected freight transport is underrepresented in terms of previous research projects as supply chains become more complex and global they rely more on logistics infrastructures that must be resilient to provide seamless transport since freight transport terminals are locations where goods are assembled and dispersed they have always been a focus of security and safety concernsthe overarching objective of transcend is to provide freight transport critical infrastructure operators with an integrated set of advanced tools guidelines and technological solutions to reduce risk and enhance the protection and resilience of their critical infrastructure and interrelated critical infrastructures against physical cyber and hybrid threats the contributions will be integrated into a control tower a digital platform with embedded business intelligence giving stakeholders a shared and continuous visibility of threats and risks by breaking down silos within and between organisations to demonstrate the effectiveness of the approach five diverse cis will experiment methodological and technological solutions as pilots three leaders and two followers |
characterization and recovery of bionanoparticles for vaccine delivery and gene therapy | the doctoral network caare characterization and recovery of bionanoparticles for vaccine delivery and gene therapy focuses on a rapidly emerging field in biopharmaceutical industry and a new class of molecules the bionanoparticles bionanoparticles are currently used as conventional vaccines mrna vaccines or gene therapy these new biopharmaceuticals will satisfy an urgent medical need as they might extend the curability of todate noncurable diseases and offer treatment for rare diseases however the impact of the manufacturing process for such therapies on the final product quality and consequently on product efficacy and patient safety is still not fully understood there also is a lack of specifically trained personnel in the field of bionanoparticlesin caare we will develop new and intensified downstream processes and analytical tools which are essential to obtain a pure therapeutic product and to ensure the efficacy and safety of the therapy acib gmbh at karlsruhe institute of technology university of hamburg and university of erlangen all de institute of experimental biology and technology pt leiden university medical centre nl and icosagen ee seven associated industry partners two associated universities and one regulatory agency have formed a consortium to train 14 doctoral candidates with beyond stateofthe art bioprocess and analytical skills directed for bionanoparticle purification latest technology of process control and monitoring for advanced bionanoparticle processing downstream process development and particle characterization of bionanoparticles will be taught the appropriate skills to communicate the research outcome to the scientific community and to the general public are included in the training program we will establish a new training creating a generation of scientists that can contribute to the establishment of technologiesmethodologies in a rapidly emerging field in biopharmaceutical manufacturing |
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