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Q1.1450 | Q1 | Is TNFRSF4 a druggable gene? | There are currently no approved drugs targeting TNFRSF4, but there are 5 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TNFRSF4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3441', 'drugName': 'Ivuxolimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNFRSF4 (ENSG00000186827)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4001', 'drugName': 'Khk-4083', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNFRSF4 (ENSG00000186827)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5182', 'drugName': 'Medi-6469', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNFRSF4 (ENSG00000186827)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4580', 'drugName': 'Telazorlimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNFRSF4 (ENSG00000186827)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4578', 'drugName': 'Gsk-3174998', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNFRSF4 (ENSG00000186827)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.78 | Q1 | Is ARAF a druggable gene? | There are currently no approved drugs targeting ARAF, but there are 3 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ARAF %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4331', 'drugName': 'Tovorafenib', 'drugIsApproved': False, 'newLinkedTargets_string': 'RAF1 (ENSG00000132155), BRAF (ENSG00000157764), ARAF (ENSG00000078061)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3033', 'drugName': 'Belvarafenib', 'drugIsApproved': False, 'newLinkedTargets_string': 'RAF1 (ENSG00000132155), BRAF (ENSG00000157764), ARAF (ENSG00000078061)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5869', 'drugName': 'Ly-3009120', 'drugIsApproved': False, 'newLinkedTargets_string': 'BRAF (ENSG00000157764), ARAF (ENSG00000078061), RAF1 (ENSG00000132155)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5870', 'drugName': 'Ly-3009120', 'drugIsApproved': False, 'newLinkedTargets_string': 'BRAF (ENSG00000157764), ARAF (ENSG00000078061), RAF1 (ENSG00000132155)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5871', 'drugName': 'Ly-3009120', 'drugIsApproved': False, 'newLinkedTargets_string': 'BRAF (ENSG00000157764), ARAF (ENSG00000078061), RAF1 (ENSG00000132155)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1016 | Q1 | Is NTSR1 a druggable gene? | There are currently no approved drugs targeting NTSR1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NTSR1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4907', 'drugName': 'Reminertant', 'drugIsApproved': False, 'newLinkedTargets_string': 'NTSR1 (ENSG00000101188)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.664 | Q1 | Is IKBKB a druggable gene? | There are currently no approved drugs targeting IKBKB, but there are 7 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%IKBKB %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4921', 'drugName': 'Bardoxolone Methyl', 'drugIsApproved': False, 'newLinkedTargets_string': 'NFE2L2 (ENSG00000116044), KEAP1 (ENSG00000079999), PPARG (ENSG00000132170), IKBKB (ENSG00000104365)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4920', 'drugName': 'Bardoxolone Methyl', 'drugIsApproved': False, 'newLinkedTargets_string': 'NFE2L2 (ENSG00000116044), KEAP1 (ENSG00000079999), PPARG (ENSG00000132170), IKBKB (ENSG00000104365)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4922', 'drugName': 'Bardoxolone Methyl', 'drugIsApproved': False, 'newLinkedTargets_string': 'NFE2L2 (ENSG00000116044), KEAP1 (ENSG00000079999), PPARG (ENSG00000132170), IKBKB (ENSG00000104365)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1737', 'drugName': 'Sar-113945', 'drugIsApproved': False, 'newLinkedTargets_string': 'IKBKB (ENSG00000104365)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_337', 'drugName': 'Imd-1041', 'drugIsApproved': False, 'newLinkedTargets_string': 'IKBKB (ENSG00000104365)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1504', 'drugName': 'As-602868', 'drugIsApproved': False, 'newLinkedTargets_string': 'IKBKB (ENSG00000104365), FLT3 (ENSG00000122025)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1215', 'drugName': 'Imd-0354', 'drugIsApproved': False, 'newLinkedTargets_string': 'IKBKB (ENSG00000104365)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2089', 'drugName': 'Imd-2560', 'drugIsApproved': False, 'newLinkedTargets_string': 'IKBKB (ENSG00000104365)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5834', 'drugName': 'Mln-0415', 'drugIsApproved': False, 'newLinkedTargets_string': 'IKBKB (ENSG00000104365)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1505', 'drugName': 'As-602868', 'drugIsApproved': False, 'newLinkedTargets_string': 'IKBKB (ENSG00000104365), FLT3 (ENSG00000122025)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1140 | Q1 | Is PRKCI a druggable gene? | There is 1 drug, Midostaurin, that targets PRKCI, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PRKCI %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5666', 'drugName': 'Midostaurin', 'drugIsApproved': True, 'newLinkedTargets_string': 'KIT (ENSG00000157404), KDR (ENSG00000128052), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), FLT3 (ENSG00000122025), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5664', 'drugName': 'Midostaurin', 'drugIsApproved': True, 'newLinkedTargets_string': 'KIT (ENSG00000157404), KDR (ENSG00000128052), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), FLT3 (ENSG00000122025), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5667', 'drugName': 'Midostaurin', 'drugIsApproved': True, 'newLinkedTargets_string': 'KIT (ENSG00000157404), KDR (ENSG00000128052), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), FLT3 (ENSG00000122025), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5665', 'drugName': 'Midostaurin', 'drugIsApproved': True, 'newLinkedTargets_string': 'KIT (ENSG00000157404), KDR (ENSG00000128052), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), FLT3 (ENSG00000122025), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5668', 'drugName': 'Midostaurin', 'drugIsApproved': True, 'newLinkedTargets_string': 'KIT (ENSG00000157404), KDR (ENSG00000128052), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), FLT3 (ENSG00000122025), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4663', 'drugName': 'Ucn-01', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDPK1 (ENSG00000140992), CDK2 (ENSG00000123374), CDK4 (ENSG00000135446), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675), CDK6 (ENSG00000105810), CHEK1 (ENSG00000149554)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4658', 'drugName': 'Ucn-01', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDPK1 (ENSG00000140992), CDK2 (ENSG00000123374), CDK4 (ENSG00000135446), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675), CDK6 (ENSG00000105810), CHEK1 (ENSG00000149554)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4662', 'drugName': 'Ucn-01', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDPK1 (ENSG00000140992), CDK2 (ENSG00000123374), CDK4 (ENSG00000135446), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675), CDK6 (ENSG00000105810), CHEK1 (ENSG00000149554)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4660', 'drugName': 'Ucn-01', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDPK1 (ENSG00000140992), CDK2 (ENSG00000123374), CDK4 (ENSG00000135446), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675), CDK6 (ENSG00000105810), CHEK1 (ENSG00000149554)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1322', 'drugName': 'Sotrastaurin', 'drugIsApproved': False, 'newLinkedTargets_string': 'PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4661', 'drugName': 'Ucn-01', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDPK1 (ENSG00000140992), CDK2 (ENSG00000123374), CDK4 (ENSG00000135446), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675), CDK6 (ENSG00000105810), CHEK1 (ENSG00000149554)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4659', 'drugName': 'Ucn-01', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDPK1 (ENSG00000140992), CDK2 (ENSG00000123374), CDK4 (ENSG00000135446), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675), CDK6 (ENSG00000105810), CHEK1 (ENSG00000149554)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3701', 'drugName': 'Cep-2563', 'drugIsApproved': False, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675), NTRK1 (ENSG00000198400), NTRK2 (ENSG00000148053), NTRK3 (ENSG00000140538)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1836', 'drugName': 'Gsk-690693', 'drugIsApproved': False, 'newLinkedTargets_string': 'PRKACB (ENSG00000142875), PRKACA (ENSG00000072062), PRKACG (ENSG00000165059), AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1835', 'drugName': 'Gsk-690693', 'drugIsApproved': False, 'newLinkedTargets_string': 'PRKACB (ENSG00000142875), PRKACA (ENSG00000072062), PRKACG (ENSG00000165059), AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3697', 'drugName': 'Cep-2563', 'drugIsApproved': False, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675), NTRK1 (ENSG00000198400), NTRK2 (ENSG00000148053), NTRK3 (ENSG00000140538)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3698', 'drugName': 'Cep-2563', 'drugIsApproved': False, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675), NTRK1 (ENSG00000198400), NTRK2 (ENSG00000148053), NTRK3 (ENSG00000140538)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3699', 'drugName': 'Cep-2563', 'drugIsApproved': False, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675), NTRK1 (ENSG00000198400), NTRK2 (ENSG00000148053), NTRK3 (ENSG00000140538)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3700', 'drugName': 'Cep-2563', 'drugIsApproved': False, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675), NTRK1 (ENSG00000198400), NTRK2 (ENSG00000148053), NTRK3 (ENSG00000140538)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1837', 'drugName': 'Gsk-690693', 'drugIsApproved': False, 'newLinkedTargets_string': 'PRKACB (ENSG00000142875), PRKACA (ENSG00000072062), PRKACG (ENSG00000165059), AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.988 | Q1 | Is NOS3 a druggable gene? | There are currently no approved drugs targeting NOS3, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NOS3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_890', 'drugName': 'Tilarginine', 'drugIsApproved': False, 'newLinkedTargets_string': 'NOS1 (ENSG00000089250), NOS2 (ENSG00000007171), NOS3 (ENSG00000164867)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1662', 'drugName': 'Tilarginine Acetate', 'drugIsApproved': False, 'newLinkedTargets_string': 'NOS1 (ENSG00000089250), NOS2 (ENSG00000007171), NOS3 (ENSG00000164867)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1421 | Q1 | Is TFR2 a druggable gene? | There are currently no approved drugs targeting TFR2, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TFR2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3234', 'drugName': 'Pabinafusp Alfa', 'drugIsApproved': False, 'newLinkedTargets_string': 'TFRC (ENSG00000072274), TFR2 (ENSG00000106327)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4473', 'drugName': 'E2.3', 'drugIsApproved': False, 'newLinkedTargets_string': 'TFRC (ENSG00000072274), TFR2 (ENSG00000106327)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1509 | Q1 | Is TUBB8B a druggable gene? | There are currently no approved drugs targeting TUBB8B, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TUBB8B %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3400', 'drugName': 'Abt-751', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBB3 (ENSG00000258947), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), TUBB8B (ENSG00000173213)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1345 | Q1 | Is SELE a druggable gene? | There are currently no approved drugs targeting SELE, but there are 4 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SELE %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2473', 'drugName': 'Rivipansel', 'drugIsApproved': False, 'newLinkedTargets_string': 'SELE (ENSG00000007908), SELP (ENSG00000174175), SELL (ENSG00000188404)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2474', 'drugName': 'Rivipansel', 'drugIsApproved': False, 'newLinkedTargets_string': 'SELE (ENSG00000007908), SELP (ENSG00000174175), SELL (ENSG00000188404)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2418', 'drugName': 'Uproleselan', 'drugIsApproved': False, 'newLinkedTargets_string': 'SELE (ENSG00000007908)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2475', 'drugName': 'Rivipansel', 'drugIsApproved': False, 'newLinkedTargets_string': 'SELE (ENSG00000007908), SELP (ENSG00000174175), SELL (ENSG00000188404)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1808', 'drugName': 'Bimosiamose', 'drugIsApproved': False, 'newLinkedTargets_string': 'SELL (ENSG00000188404), SELE (ENSG00000007908), SELP (ENSG00000174175)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5392', 'drugName': 'Cdp-850', 'drugIsApproved': False, 'newLinkedTargets_string': 'SELE (ENSG00000007908)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1197 | Q1 | Is PTGS1 a druggable gene? | There are currently 61 approved drugs which target PTGS1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PTGS1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2814', 'drugName': 'Dipyrone', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5291', 'drugName': 'Naproxen Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4888', 'drugName': 'Mefenamic Acid', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_579', 'drugName': 'Glafenine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1446', 'drugName': 'Dexibuprofen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3917', 'drugName': 'Apazone', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5752', 'drugName': 'Lornoxicam', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4669', 'drugName': 'Oxyphenbutazone', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_172', 'drugName': 'Oxyphenbutazone', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3165', 'drugName': 'Indomethacin', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1367', 'drugName': 'Bismuth Subsalicylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4517', 'drugName': 'Naproxen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4670', 'drugName': 'Fenoprofen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4334', 'drugName': 'Dipyrone', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1297', 'drugName': 'Balsalazide Disodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), ALOX5 (ENSG00000012779)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1392', 'drugName': 'Tolmetin Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_737', 'drugName': 'Sulindac', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1802', 'drugName': 'Isoxicam', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4421', 'drugName': 'Phenylbutazone', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_602', 'drugName': 'Diflunisal', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2069', 'drugName': 'Piroxicam', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5877', 'drugName': 'Ketoprofen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3122', 'drugName': 'Diclofenac', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2818', 'drugName': 'Diclofenac Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2258', 'drugName': 'Ketorolac Tromethamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4826', 'drugName': 'Ketorolac', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5263', 'drugName': 'Diclofenac Potassium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1078', 'drugName': 'Balsalazide', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), ALOX5 (ENSG00000012779)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_989', 'drugName': 'Bromfenac Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5375', 'drugName': 'Bromfenac', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5261', 'drugName': 'Nepafenac', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3087', 'drugName': 'Diclofenac Epolamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4357', 'drugName': 'Indoprofen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1508', 'drugName': 'Fenclofenac', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3434', 'drugName': 'Antipyrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5314', 'drugName': 'Dexketoprofen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4252', 'drugName': 'Indomethacin Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_792', 'drugName': 'Suprofen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2737', 'drugName': 'Flurbiprofen Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4018', 'drugName': 'Pirprofen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3630', 'drugName': 'Oxaprozin Potassium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4050', 'drugName': 'Ibuprofen Lysine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_566', 'drugName': 'Ibuprofen Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1079', 'drugName': 'Balsalazide', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), ALOX5 (ENSG00000012779)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3586', 'drugName': 'Ibufenac', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5380', 'drugName': 'Clometacin', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_229', 'drugName': 'Aloxiprin', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1298', 'drugName': 'Balsalazide Disodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), ALOX5 (ENSG00000012779)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3015', 'drugName': 'Sulfasalazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ALOX5 (ENSG00000012779), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3016', 'drugName': 'Sulfasalazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ALOX5 (ENSG00000012779), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3724', 'drugName': 'Meclofenamate Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ALOX5 (ENSG00000012779), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5034', 'drugName': 'Meclofenamic Acid', 'drugIsApproved': True, 'newLinkedTargets_string': 'ALOX5 (ENSG00000012779), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5035', 'drugName': 'Meclofenamic Acid', 'drugIsApproved': True, 'newLinkedTargets_string': 'ALOX5 (ENSG00000012779), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_146', 'drugName': 'Acetaminophen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), TRPV1 (ENSG00000196689), FAAH (ENSG00000117480)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_147', 'drugName': 'Acetaminophen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), TRPV1 (ENSG00000196689), FAAH (ENSG00000117480)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_148', 'drugName': 'Acetaminophen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), TRPV1 (ENSG00000196689), FAAH (ENSG00000117480)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6047', 'drugName': 'Mesalamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), ALOX5 (ENSG00000012779), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6049', 'drugName': 'Mesalamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), ALOX5 (ENSG00000012779), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4289', 'drugName': 'Olsalazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), ALOX5 (ENSG00000012779)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4290', 'drugName': 'Olsalazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), ALOX5 (ENSG00000012779)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4291', 'drugName': 'Olsalazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), ALOX5 (ENSG00000012779)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3913', 'drugName': 'Olsalazine Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), ALOX5 (ENSG00000012779)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3914', 'drugName': 'Olsalazine Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), ALOX5 (ENSG00000012779)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3915', 'drugName': 'Olsalazine Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), ALOX5 (ENSG00000012779)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1077', 'drugName': 'Balsalazide', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), ALOX5 (ENSG00000012779)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1296', 'drugName': 'Balsalazide Disodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), ALOX5 (ENSG00000012779)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3725', 'drugName': 'Meclofenamate Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ALOX5 (ENSG00000012779), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5775', 'drugName': 'Flurbiprofen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1563', 'drugName': 'Aspirin', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3576', 'drugName': 'Benzydamine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3320', 'drugName': 'Alclofenac', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3840', 'drugName': 'Acemetacin', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3093', 'drugName': 'Fenoprofen Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6048', 'drugName': 'Mesalamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), ALOX5 (ENSG00000012779), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2747', 'drugName': 'Oxaprozin', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3209', 'drugName': 'Ibuprofen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5527', 'drugName': 'Tolmetin', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1474', 'drugName': 'Benzydamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1782', 'drugName': 'Naproxcinod', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5008', 'drugName': 'Esflurbiprofen', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2702', 'drugName': 'Loxoprofen', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5387', 'drugName': 'Naproxen Etemesil', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2051', 'drugName': 'Mofezolac', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': -1}, {'UUID': 'DrugGeneTargets_v2_5733', 'drugName': 'Diclofenac Etalhyaluronate Sodium', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': -1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1215 | Q1 | Is RELA a druggable gene? | There are currently no approved drugs targeting RELA, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RELA %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1568', 'drugName': 'Edasalonexent', 'drugIsApproved': False, 'newLinkedTargets_string': 'NFKB2 (ENSG00000077150), NFKB1 (ENSG00000109320), RELA (ENSG00000173039)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.632 | Q1 | Is HTT a druggable gene? | There are currently no approved drugs targeting HTT, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HTT %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3493', 'drugName': 'Tominersen', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTT (ENSG00000197386)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.396 | Q1 | Is EGLN3 a druggable gene? | There is 1 drug, Roxadustat, that targets EGLN3, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%EGLN3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5393', 'drugName': 'Roxadustat', 'drugIsApproved': True, 'newLinkedTargets_string': 'EGLN2 (ENSG00000269858), P4HTM (ENSG00000178467), EGLN1 (ENSG00000135766), EGLN3 (ENSG00000129521)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2677', 'drugName': 'Daprodustat', 'drugIsApproved': False, 'newLinkedTargets_string': 'EGLN2 (ENSG00000269858), P4HTM (ENSG00000178467), EGLN1 (ENSG00000135766), EGLN3 (ENSG00000129521)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5157', 'drugName': 'Vadadustat', 'drugIsApproved': False, 'newLinkedTargets_string': 'EGLN3 (ENSG00000129521), EGLN1 (ENSG00000135766), EGLN2 (ENSG00000269858)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5155', 'drugName': 'Vadadustat', 'drugIsApproved': False, 'newLinkedTargets_string': 'EGLN3 (ENSG00000129521), EGLN1 (ENSG00000135766), EGLN2 (ENSG00000269858)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5156', 'drugName': 'Vadadustat', 'drugIsApproved': False, 'newLinkedTargets_string': 'EGLN3 (ENSG00000129521), EGLN1 (ENSG00000135766), EGLN2 (ENSG00000269858)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2680', 'drugName': 'Molidustat', 'drugIsApproved': False, 'newLinkedTargets_string': 'EGLN2 (ENSG00000269858), EGLN1 (ENSG00000135766), EGLN3 (ENSG00000129521)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2679', 'drugName': 'Molidustat', 'drugIsApproved': False, 'newLinkedTargets_string': 'EGLN2 (ENSG00000269858), EGLN1 (ENSG00000135766), EGLN3 (ENSG00000129521)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2681', 'drugName': 'Molidustat', 'drugIsApproved': False, 'newLinkedTargets_string': 'EGLN2 (ENSG00000269858), EGLN1 (ENSG00000135766), EGLN3 (ENSG00000129521)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1489 | Q1 | Is TSHR a druggable gene? | There are currently 2 approved drugs which target TSHR, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TSHR %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2659', 'drugName': 'Thyrotropin Alfa', 'drugIsApproved': True, 'newLinkedTargets_string': 'TSHR (ENSG00000165409)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3423', 'drugName': 'Thyrotropin', 'drugIsApproved': True, 'newLinkedTargets_string': 'TSHR (ENSG00000165409)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.517 | Q1 | Is GHR a druggable gene? | There are currently 6 approved drugs which target GHR, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GHR %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3588', 'drugName': 'Somapacitan', 'drugIsApproved': True, 'newLinkedTargets_string': 'GHR (ENSG00000112964)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1805', 'drugName': 'Pegvisomant', 'drugIsApproved': True, 'newLinkedTargets_string': 'GHR (ENSG00000112964)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5635', 'drugName': 'Somatropin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GHR (ENSG00000112964)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_959', 'drugName': 'Somatrem', 'drugIsApproved': True, 'newLinkedTargets_string': 'GHR (ENSG00000112964)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2482', 'drugName': 'Lonapegsomatropin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GHR (ENSG00000112964)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3230', 'drugName': 'Somatrogon', 'drugIsApproved': True, 'newLinkedTargets_string': 'GHR (ENSG00000112964)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.630 | Q1 | Is HTR6 a druggable gene? | There are currently 5 approved drugs which target HTR6, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HTR6 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2863', 'drugName': 'Dexfenfluramine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1377', 'drugName': 'Amisulpride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3880', 'drugName': 'Dexfenfluramine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6383', 'drugName': 'Zimeldine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1378', 'drugName': 'Amisulpride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_893', 'drugName': 'Zimeldine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1860', 'drugName': 'Idalopirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR6 (ENSG00000158748)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4255', 'drugName': 'Masupirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR6 (ENSG00000158748)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2778', 'drugName': 'Intepirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR6 (ENSG00000158748)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_565', 'drugName': 'Pf-05212377', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR6 (ENSG00000158748)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5965', 'drugName': 'Cerlapirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR6 (ENSG00000158748)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1122 | Q1 | Is PRIM1 a druggable gene? | There are currently 5 approved drugs which target PRIM1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PRIM1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4', 'drugName': 'Gemcitabine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'POLA1 (ENSG00000101868), POLD4 (ENSG00000175482), POLD3 (ENSG00000077514), POLD1 (ENSG00000062822), POLD2 (ENSG00000106628), POLE (ENSG00000177084), POLA2 (ENSG00000014138), PRIM1 (ENSG00000198056), PRIM2 (ENSG00000146143), POLE2 (ENSG00000100479), POLE3 (ENSG00000148229), RRM1 (ENSG00000167325), RRM2B (ENSG00000048392), RRM2 (ENSG00000171848)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4349', 'drugName': 'Cytarabine', 'drugIsApproved': True, 'newLinkedTargets_string': 'POLA1 (ENSG00000101868), POLD4 (ENSG00000175482), POLD3 (ENSG00000077514), POLD1 (ENSG00000062822), POLD2 (ENSG00000106628), POLE (ENSG00000177084), POLA2 (ENSG00000014138), PRIM1 (ENSG00000198056), PRIM2 (ENSG00000146143), POLE2 (ENSG00000100479), POLE3 (ENSG00000148229)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2785', 'drugName': 'Clofarabine', 'drugIsApproved': True, 'newLinkedTargets_string': 'POLA1 (ENSG00000101868), POLD4 (ENSG00000175482), POLD3 (ENSG00000077514), POLD1 (ENSG00000062822), POLD2 (ENSG00000106628), POLE (ENSG00000177084), POLA2 (ENSG00000014138), PRIM1 (ENSG00000198056), PRIM2 (ENSG00000146143), POLE2 (ENSG00000100479), POLE3 (ENSG00000148229), RRM1 (ENSG00000167325), RRM2B (ENSG00000048392), RRM2 (ENSG00000171848)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2786', 'drugName': 'Clofarabine', 'drugIsApproved': True, 'newLinkedTargets_string': 'POLA1 (ENSG00000101868), POLD4 (ENSG00000175482), POLD3 (ENSG00000077514), POLD1 (ENSG00000062822), POLD2 (ENSG00000106628), POLE (ENSG00000177084), POLA2 (ENSG00000014138), PRIM1 (ENSG00000198056), PRIM2 (ENSG00000146143), POLE2 (ENSG00000100479), POLE3 (ENSG00000148229), RRM1 (ENSG00000167325), RRM2B (ENSG00000048392), RRM2 (ENSG00000171848)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2916', 'drugName': 'Fludarabine Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'RRM1 (ENSG00000167325), RRM2B (ENSG00000048392), RRM2 (ENSG00000171848), POLA1 (ENSG00000101868), POLD4 (ENSG00000175482), POLD3 (ENSG00000077514), POLD1 (ENSG00000062822), POLD2 (ENSG00000106628), POLE (ENSG00000177084), POLA2 (ENSG00000014138), PRIM1 (ENSG00000198056), PRIM2 (ENSG00000146143), POLE2 (ENSG00000100479), POLE3 (ENSG00000148229)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_66', 'drugName': 'Gemcitabine', 'drugIsApproved': True, 'newLinkedTargets_string': 'POLA1 (ENSG00000101868), POLD4 (ENSG00000175482), POLD3 (ENSG00000077514), POLD1 (ENSG00000062822), POLD2 (ENSG00000106628), POLE (ENSG00000177084), POLA2 (ENSG00000014138), PRIM1 (ENSG00000198056), PRIM2 (ENSG00000146143), POLE2 (ENSG00000100479), POLE3 (ENSG00000148229), RRM1 (ENSG00000167325), RRM2B (ENSG00000048392), RRM2 (ENSG00000171848)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2917', 'drugName': 'Fludarabine Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'RRM1 (ENSG00000167325), RRM2B (ENSG00000048392), RRM2 (ENSG00000171848), POLA1 (ENSG00000101868), POLD4 (ENSG00000175482), POLD3 (ENSG00000077514), POLD1 (ENSG00000062822), POLD2 (ENSG00000106628), POLE (ENSG00000177084), POLA2 (ENSG00000014138), PRIM1 (ENSG00000198056), PRIM2 (ENSG00000146143), POLE2 (ENSG00000100479), POLE3 (ENSG00000148229)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_65', 'drugName': 'Gemcitabine', 'drugIsApproved': True, 'newLinkedTargets_string': 'POLA1 (ENSG00000101868), POLD4 (ENSG00000175482), POLD3 (ENSG00000077514), POLD1 (ENSG00000062822), POLD2 (ENSG00000106628), POLE (ENSG00000177084), POLA2 (ENSG00000014138), PRIM1 (ENSG00000198056), PRIM2 (ENSG00000146143), POLE2 (ENSG00000100479), POLE3 (ENSG00000148229), RRM1 (ENSG00000167325), RRM2B (ENSG00000048392), RRM2 (ENSG00000171848)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5', 'drugName': 'Gemcitabine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'POLA1 (ENSG00000101868), POLD4 (ENSG00000175482), POLD3 (ENSG00000077514), POLD1 (ENSG00000062822), POLD2 (ENSG00000106628), POLE (ENSG00000177084), POLA2 (ENSG00000014138), PRIM1 (ENSG00000198056), PRIM2 (ENSG00000146143), POLE2 (ENSG00000100479), POLE3 (ENSG00000148229), RRM1 (ENSG00000167325), RRM2B (ENSG00000048392), RRM2 (ENSG00000171848)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3529', 'drugName': 'Aspacytarabine', 'drugIsApproved': False, 'newLinkedTargets_string': 'POLA1 (ENSG00000101868), POLD4 (ENSG00000175482), POLD3 (ENSG00000077514), POLD1 (ENSG00000062822), POLD2 (ENSG00000106628), POLE (ENSG00000177084), POLA2 (ENSG00000014138), PRIM1 (ENSG00000198056), PRIM2 (ENSG00000146143), POLE2 (ENSG00000100479), POLE3 (ENSG00000148229)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5766', 'drugName': 'Troxacitabine', 'drugIsApproved': False, 'newLinkedTargets_string': 'POLA1 (ENSG00000101868), POLD4 (ENSG00000175482), POLD3 (ENSG00000077514), POLD1 (ENSG00000062822), POLD2 (ENSG00000106628), POLE (ENSG00000177084), POLA2 (ENSG00000014138), PRIM1 (ENSG00000198056), PRIM2 (ENSG00000146143), POLE2 (ENSG00000100479), POLE3 (ENSG00000148229)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.31 | Q1 | Is ADORA3 a druggable gene? | There are currently 8 approved drugs which target ADORA3, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ADORA3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5471', 'drugName': 'Aminophylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1105', 'drugName': 'Adenosine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4548', 'drugName': 'Theophylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271), PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5470', 'drugName': 'Aminophylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6075', 'drugName': 'Caffeine, Citrated', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3797', 'drugName': 'Oxtriphylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3798', 'drugName': 'Oxtriphylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_955', 'drugName': 'Theophylline Sodium Glycinate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_956', 'drugName': 'Theophylline Sodium Glycinate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_957', 'drugName': 'Theophylline Sodium Glycinate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2663', 'drugName': 'Theophylline Glycinate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE3A (ENSG00000172572), PDE3B (ENSG00000152270)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3799', 'drugName': 'Oxtriphylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4546', 'drugName': 'Theophylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271), PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5472', 'drugName': 'Aminophylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4547', 'drugName': 'Theophylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271), PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2664', 'drugName': 'Theophylline Glycinate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE3A (ENSG00000172572), PDE3B (ENSG00000152270)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2662', 'drugName': 'Theophylline Glycinate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE3A (ENSG00000172572), PDE3B (ENSG00000152270)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4744', 'drugName': 'Caffeine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425), ADORA3 (ENSG00000282608), ADORA2A (ENSG00000128271)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2477', 'drugName': 'Piclidenoson', 'drugIsApproved': False, 'newLinkedTargets_string': 'ADORA3 (ENSG00000282608)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2774', 'drugName': 'Namodenoson', 'drugIsApproved': False, 'newLinkedTargets_string': 'ADORA3 (ENSG00000282608)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5644', 'drugName': 'Qaf805', 'drugIsApproved': False, 'newLinkedTargets_string': 'ADORA3 (ENSG00000282608), ADORA2B (ENSG00000170425)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5645', 'drugName': 'Qaf805', 'drugIsApproved': False, 'newLinkedTargets_string': 'ADORA3 (ENSG00000282608), ADORA2B (ENSG00000170425)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.50 | Q1 | Is AKT2 a druggable gene? | There are currently no approved drugs targeting AKT2, but there are 14 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%AKT2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2935', 'drugName': 'Ipatasertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6037', 'drugName': 'Capivasertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_511', 'drugName': 'Triciribine Phosphate', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_417', 'drugName': 'Miransertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2439', 'drugName': 'Uprosertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2222', 'drugName': 'Afuresertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3076', 'drugName': 'Tas-117', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2618', 'drugName': 'Mk-2206', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1837', 'drugName': 'Gsk-690693', 'drugIsApproved': False, 'newLinkedTargets_string': 'PRKACB (ENSG00000142875), PRKACA (ENSG00000072062), PRKACG (ENSG00000165059), AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2169', 'drugName': 'Xl-418', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), RPS6KB2 (ENSG00000175634), RPS6KB1 (ENSG00000108443)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1380', 'drugName': 'Mk-2201', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1836', 'drugName': 'Gsk-690693', 'drugIsApproved': False, 'newLinkedTargets_string': 'PRKACB (ENSG00000142875), PRKACA (ENSG00000072062), PRKACG (ENSG00000165059), AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_482', 'drugName': 'Bay-1125976', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT1 (ENSG00000142208), AKT2 (ENSG00000105221)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5896', 'drugName': 'Ly-2780301', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), RPS6KB2 (ENSG00000175634), RPS6KB1 (ENSG00000108443)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3347', 'drugName': 'Tas0612', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPS6KB2 (ENSG00000175634), RPS6KB1 (ENSG00000108443), AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), RPS6KA3 (ENSG00000177189), RPS6KA2 (ENSG00000071242), RPS6KA6 (ENSG00000072133), RPS6KA1 (ENSG00000117676)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3348', 'drugName': 'Tas0612', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPS6KB2 (ENSG00000175634), RPS6KB1 (ENSG00000108443), AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), RPS6KA3 (ENSG00000177189), RPS6KA2 (ENSG00000071242), RPS6KA6 (ENSG00000072133), RPS6KA1 (ENSG00000117676)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_481', 'drugName': 'Bay-1125976', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT1 (ENSG00000142208), AKT2 (ENSG00000105221)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3349', 'drugName': 'Tas0612', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPS6KB2 (ENSG00000175634), RPS6KB1 (ENSG00000108443), AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), RPS6KA3 (ENSG00000177189), RPS6KA2 (ENSG00000071242), RPS6KA6 (ENSG00000072133), RPS6KA1 (ENSG00000117676)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1835', 'drugName': 'Gsk-690693', 'drugIsApproved': False, 'newLinkedTargets_string': 'PRKACB (ENSG00000142875), PRKACA (ENSG00000072062), PRKACG (ENSG00000165059), AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (ENSG00000126583), PRKCD (ENSG00000163932), PRKCB (ENSG00000166501), PRKCZ (ENSG00000067606), PRKCE (ENSG00000171132), PRKCH (ENSG00000027075), PRKD1 (ENSG00000184304), PRKCQ (ENSG00000065675)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5897', 'drugName': 'Ly-2780301', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), RPS6KB2 (ENSG00000175634), RPS6KB1 (ENSG00000108443)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2168', 'drugName': 'Xl-418', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), RPS6KB2 (ENSG00000175634), RPS6KB1 (ENSG00000108443)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.242 | Q1 | Is CDK20 a druggable gene? | There are currently no approved drugs targeting CDK20, but there are 4 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CDK20 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1429', 'drugName': 'Roniciclib', 'drugIsApproved': False, 'newLinkedTargets_string': 'CDK1 (ENSG00000170312), CDK4 (ENSG00000135446), CDK2 (ENSG00000123374), CDK5 (ENSG00000164885), CDK6 (ENSG00000105810), CDK7 (ENSG00000134058), CDK3 (ENSG00000250506), CDK16 (ENSG00000102225), CDK18 (ENSG00000117266), CDK8 (ENSG00000132964), CDK17 (ENSG00000059758), CDK11B (ENSG00000248333), CDK15 (ENSG00000138395), CDK19 (ENSG00000155111), CDK14 (ENSG00000058091), CDK9 (ENSG00000136807), CDK10 (ENSG00000185324), CDK13 (ENSG00000065883), CDK20 (ENSG00000156345), CDK12 (ENSG00000167258)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2272', 'drugName': 'At-7519', 'drugIsApproved': False, 'newLinkedTargets_string': 'CDK1 (ENSG00000170312), CDK4 (ENSG00000135446), CDK2 (ENSG00000123374), CDK5 (ENSG00000164885), CDK6 (ENSG00000105810), CDK7 (ENSG00000134058), CDK3 (ENSG00000250506), CDK16 (ENSG00000102225), CDK18 (ENSG00000117266), CDK8 (ENSG00000132964), CDK17 (ENSG00000059758), CDK11B (ENSG00000248333), CDK15 (ENSG00000138395), CDK19 (ENSG00000155111), CDK14 (ENSG00000058091), CDK9 (ENSG00000136807), CDK10 (ENSG00000185324), CDK13 (ENSG00000065883), CDK20 (ENSG00000156345), CDK12 (ENSG00000167258)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1722', 'drugName': 'Pha-793887', 'drugIsApproved': False, 'newLinkedTargets_string': 'CDK1 (ENSG00000170312), CDK4 (ENSG00000135446), CDK2 (ENSG00000123374), CDK5 (ENSG00000164885), CDK6 (ENSG00000105810), CDK7 (ENSG00000134058), CDK3 (ENSG00000250506), CDK16 (ENSG00000102225), CDK18 (ENSG00000117266), CDK8 (ENSG00000132964), CDK17 (ENSG00000059758), CDK11B (ENSG00000248333), CDK15 (ENSG00000138395), CDK19 (ENSG00000155111), CDK14 (ENSG00000058091), CDK9 (ENSG00000136807), CDK10 (ENSG00000185324), CDK13 (ENSG00000065883), CDK20 (ENSG00000156345), CDK12 (ENSG00000167258)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1909', 'drugName': 'Azd-5438', 'drugIsApproved': False, 'newLinkedTargets_string': 'CDK1 (ENSG00000170312), CDK4 (ENSG00000135446), CDK2 (ENSG00000123374), CDK5 (ENSG00000164885), CDK6 (ENSG00000105810), CDK7 (ENSG00000134058), CDK3 (ENSG00000250506), CDK16 (ENSG00000102225), CDK18 (ENSG00000117266), CDK8 (ENSG00000132964), CDK17 (ENSG00000059758), CDK11B (ENSG00000248333), CDK15 (ENSG00000138395), CDK19 (ENSG00000155111), CDK14 (ENSG00000058091), CDK9 (ENSG00000136807), CDK10 (ENSG00000185324), CDK13 (ENSG00000065883), CDK20 (ENSG00000156345), CDK12 (ENSG00000167258)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.431 | Q1 | Is ESR2 a druggable gene? | There are currently 22 approved drugs which target ESR2, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ESR2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1689', 'drugName': 'Toremifene Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4127', 'drugName': 'Diethylstilbestrol Diphosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4010', 'drugName': 'Quinestrol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1341', 'drugName': 'Bazedoxifene Acetate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3168', 'drugName': 'Estrogens, Esterified', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4209', 'drugName': 'Synthetic Conjugated Estrogens, B', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5980', 'drugName': 'Bazedoxifene', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5682', 'drugName': 'Estrogens, Conjugated', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5777', 'drugName': 'Raloxifene', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1475', 'drugName': 'Cyclofenil', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5789', 'drugName': 'Estramustine Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1120', 'drugName': 'Allylestrenol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831), PGR (ENSG00000082175)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3057', 'drugName': 'Ospemifene', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5377', 'drugName': 'Estramustine Phosphate Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1083', 'drugName': 'Toremifene', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5561', 'drugName': 'Fulvestrant', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4568', 'drugName': 'Estetrol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1839', 'drugName': 'Raloxifene Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5303', 'drugName': 'Lasofoxifene', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1121', 'drugName': 'Allylestrenol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831), PGR (ENSG00000082175)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5680', 'drugName': 'Estrogens, Conjugated Synthetic A', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_223', 'drugName': 'Estriol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3631', 'drugName': 'Chlorotrianisene', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5487', 'drugName': 'Droloxifene', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2270', 'drugName': 'Mf101', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5112', 'drugName': 'Afimoxifene', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESRRG (ENSG00000196482), ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_645', 'drugName': 'Arzoxifene', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_280', 'drugName': 'Acolbifene', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5111', 'drugName': 'Afimoxifene', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESRRG (ENSG00000196482), ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3696', 'drugName': 'Mk-6913', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3445', 'drugName': 'Prinaberel', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6071', 'drugName': 'Idoxifene', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1524', 'drugName': 'Cr 1447', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), AR (ENSG00000169083)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3545', 'drugName': 'Erteberel', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2079', 'drugName': 'Fispemifene', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6316', 'drugName': 'Aus-131', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1525', 'drugName': 'Cr 1447', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), AR (ENSG00000169083)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5514', 'drugName': 'Ly2245461', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2971', 'drugName': 'Chf4227', 'drugIsApproved': False, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.353 | Q1 | Is CYSLTR1 a druggable gene? | There are currently 3 approved drugs which target CYSLTR1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CYSLTR1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2453', 'drugName': 'Montelukast Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYSLTR1 (ENSG00000173198)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3211', 'drugName': 'Zafirlukast', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYSLTR1 (ENSG00000173198)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2189', 'drugName': 'Montelukast', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYSLTR1 (ENSG00000173198)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2311', 'drugName': 'Pranlukast', 'drugIsApproved': False, 'newLinkedTargets_string': 'CYSLTR1 (ENSG00000173198)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2602', 'drugName': 'Cr-3465', 'drugIsApproved': False, 'newLinkedTargets_string': 'CYSLTR1 (ENSG00000173198)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.126 | Q1 | Is C1S a druggable gene? | There are currently 2 approved drugs which target C1S, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%C1S %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2064', 'drugName': 'Human C1-Esterase Inhibitor', 'drugIsApproved': True, 'newLinkedTargets_string': 'C1S (ENSG00000182326), F11 (ENSG00000088926), KLKB1 (ENSG00000164344), F12 (ENSG00000131187)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3495', 'drugName': 'Sutimlimab', 'drugIsApproved': True, 'newLinkedTargets_string': 'C1S (ENSG00000182326)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2062', 'drugName': 'Human C1-Esterase Inhibitor', 'drugIsApproved': True, 'newLinkedTargets_string': 'C1S (ENSG00000182326), F11 (ENSG00000088926), KLKB1 (ENSG00000164344), F12 (ENSG00000131187)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2065', 'drugName': 'Human C1-Esterase Inhibitor', 'drugIsApproved': True, 'newLinkedTargets_string': 'C1S (ENSG00000182326), F11 (ENSG00000088926), KLKB1 (ENSG00000164344), F12 (ENSG00000131187)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2063', 'drugName': 'Human C1-Esterase Inhibitor', 'drugIsApproved': True, 'newLinkedTargets_string': 'C1S (ENSG00000182326), F11 (ENSG00000088926), KLKB1 (ENSG00000164344), F12 (ENSG00000131187)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.554 | Q1 | Is GRIN3B a druggable gene? | There are currently 14 approved drugs which target GRIN3B, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GRIN3B %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6209', 'drugName': 'Orphenadrine Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4206', 'drugName': 'Amantadine', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4606', 'drugName': 'Memantine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4307', 'drugName': 'Orphenadrine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1046', 'drugName': 'Acamprosate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_164', 'drugName': 'Acamprosate Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4305', 'drugName': 'Orphenadrine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6210', 'drugName': 'Orphenadrine Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4482', 'drugName': 'Esketamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_817', 'drugName': 'Esketamine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1047', 'drugName': 'Acamprosate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6212', 'drugName': 'Orphenadrine Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4207', 'drugName': 'Amantadine', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1959', 'drugName': 'Ketamine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_69', 'drugName': 'Orphenadrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_70', 'drugName': 'Orphenadrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_758', 'drugName': 'Felbamate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_68', 'drugName': 'Orphenadrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_768', 'drugName': 'Amantadine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_163', 'drugName': 'Acamprosate Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_67', 'drugName': 'Orphenadrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2817', 'drugName': 'Memantine', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_769', 'drugName': 'Amantadine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4306', 'drugName': 'Orphenadrine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4308', 'drugName': 'Orphenadrine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6211', 'drugName': 'Orphenadrine Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2915', 'drugName': 'Ketamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_741', 'drugName': 'Ralfinamide', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAOB (ENSG00000069535), CACNA1B (ENSG00000148408), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_742', 'drugName': 'Ralfinamide', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAOB (ENSG00000069535), CACNA1B (ENSG00000148408), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_743', 'drugName': 'Ralfinamide', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAOB (ENSG00000069535), CACNA1B (ENSG00000148408), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5793', 'drugName': 'Neramexane Mesylate', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNA9 (ENSG00000174343), CHRNA10 (ENSG00000129749), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5794', 'drugName': 'Neramexane Mesylate', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNA9 (ENSG00000174343), CHRNA10 (ENSG00000129749), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3009', 'drugName': 'Rapastinel', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_744', 'drugName': 'Ralfinamide', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAOB (ENSG00000069535), CACNA1B (ENSG00000148408), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3404', 'drugName': 'Neramexane', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), CHRNA9 (ENSG00000174343), CHRNA10 (ENSG00000129749)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3405', 'drugName': 'Neramexane', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), CHRNA9 (ENSG00000174343), CHRNA10 (ENSG00000129749)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2523', 'drugName': 'Gw468816', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3366', 'drugName': 'Neboglamine', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2572', 'drugName': 'Perzinfotel', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1129', 'drugName': 'Indantadol', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), MAOA (ENSG00000189221)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5926', 'drugName': 'Lanicemine', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4732', 'drugName': 'Av-101', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1128', 'drugName': 'Indantadol', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), MAOA (ENSG00000189221)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5517', 'drugName': 'Apimostinel', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3819', 'drugName': 'Azd8108', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2181', 'drugName': 'Cns-5161', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': -1}, {'UUID': 'DrugGeneTargets_v2_5026', 'drugName': 'Delucemine', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': -1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1502 | Q1 | Is TUBB2A a druggable gene? | There are currently 20 approved drugs which target TUBB2A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TUBB2A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1084', 'drugName': 'Brentuximab Vedotin', 'drugIsApproved': True, 'newLinkedTargets_string': 'TNFRSF8 (ENSG00000120949), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1872', 'drugName': 'Belantamab Mafodotin', 'drugIsApproved': True, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), TNFRSF17 (ENSG00000048462)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4158', 'drugName': 'Tisotumab Vedotin', 'drugIsApproved': True, 'newLinkedTargets_string': 'F3 (ENSG00000117525), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2339', 'drugName': 'Ixabepilone', 'drugIsApproved': True, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_974', 'drugName': 'Vinflunine', 'drugIsApproved': True, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4166', 'drugName': 'Vinblastine', 'drugIsApproved': True, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5756', 'drugName': 'Trastuzumab Emtansine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ERBB2 (ENSG00000141736), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5604', 'drugName': 'Eribulin', 'drugIsApproved': True, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2795', 'drugName': 'Enfortumab Vedotin', 'drugIsApproved': True, 'newLinkedTargets_string': 'NECTIN4 (ENSG00000143217), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4743', 'drugName': 'Colchicine', 'drugIsApproved': True, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_560', 'drugName': 'Polatuzumab Vedotin', 'drugIsApproved': True, 'newLinkedTargets_string': 'CD79B (ENSG00000007312), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_561', 'drugName': 'Polatuzumab Vedotin', 'drugIsApproved': True, 'newLinkedTargets_string': 'CD79B (ENSG00000007312), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1085', 'drugName': 'Brentuximab Vedotin', 'drugIsApproved': True, 'newLinkedTargets_string': 'TNFRSF8 (ENSG00000120949), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B 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(ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4739', 'drugName': 'Lexibulin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2653', 'drugName': 'Ladiratuzumab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), SLC39A6 (ENSG00000141424)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6314', 'drugName': 'Glembatumumab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'GPNMB (ENSG00000136235), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5310', 'drugName': 'Kos-1584', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6315', 'drugName': 'Glembatumumab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'GPNMB (ENSG00000136235), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4544', 'drugName': 'Lorvotuzumab Mertansine', 'drugIsApproved': False, 'newLinkedTargets_string': 'NCAM1 (ENSG00000149294), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4545', 'drugName': 'Lorvotuzumab Mertansine', 'drugIsApproved': False, 'newLinkedTargets_string': 'NCAM1 (ENSG00000149294), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6013', 'drugName': 'Praluzatamab Ravtansine', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), ALCAM (ENSG00000170017)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5238', 'drugName': 'Sofituzumab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'MUC16 (ENSG00000181143), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5239', 'drugName': 'Sofituzumab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'MUC16 (ENSG00000181143), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_6096', 'drugName': 'Pinatuzumab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), CD22 (ENSG00000012124)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_6097', 'drugName': 'Pinatuzumab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), CD22 (ENSG00000012124)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_405', 'drugName': 'Asg-5Me', 'drugIsApproved': False, 'newLinkedTargets_string': 'SLC44A4 (ENSG00000204385), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_752', 'drugName': 'Vandortuzumab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'STEAP1 (ENSG00000164647), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_831', 'drugName': 'Rg-7841', 'drugIsApproved': False, 'newLinkedTargets_string': 'LY6E (ENSG00000160932), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_753', 'drugName': 'Vandortuzumab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'STEAP1 (ENSG00000164647), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1646', 'drugName': 'Azintuxizumab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), SLAMF7 (ENSG00000026751)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1647', 'drugName': 'Azintuxizumab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), SLAMF7 (ENSG00000026751)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_832', 'drugName': 'Rg-7841', 'drugIsApproved': False, 'newLinkedTargets_string': 'LY6E (ENSG00000160932), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1355', 'drugName': 'Pf-06263507', 'drugIsApproved': False, 'newLinkedTargets_string': 'TPBG (ENSG00000146242), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_406', 'drugName': 'Asg-5Me', 'drugIsApproved': False, 'newLinkedTargets_string': 'SLC44A4 (ENSG00000204385), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1356', 'drugName': 'Pf-06263507', 'drugIsApproved': False, 'newLinkedTargets_string': 'TPBG (ENSG00000146242), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2066', 'drugName': 'Aprutumab Ixadotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), FGFR2 (ENSG00000066468)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2067', 'drugName': 'Aprutumab Ixadotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), FGFR2 (ENSG00000066468)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_641', 'drugName': 'Rg-7600', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), MSLN (ENSG00000102854)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_642', 'drugName': 'Rg-7600', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), MSLN (ENSG00000102854)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5414', 'drugName': 'Rg-7636', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), EDNRB (ENSG00000136160)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5415', 'drugName': 'Rg-7636', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), EDNRB (ENSG00000136160)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5801', 'drugName': 'Enapotamab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'AXL (ENSG00000167601), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5802', 'drugName': 'Enapotamab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'AXL (ENSG00000167601), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_6222', 'drugName': 'Bivatuzumab Mertansine', 'drugIsApproved': False, 'newLinkedTargets_string': 'CD44 (ENSG00000026508), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_6223', 'drugName': 'Bivatuzumab Mertansine', 'drugIsApproved': False, 'newLinkedTargets_string': 'CD44 (ENSG00000026508), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.71 | Q1 | Is APH1A a druggable gene? | There are currently no approved drugs targeting APH1A, but there are 6 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%APH1A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5562', 'drugName': 'Nirogacestat', 'drugIsApproved': False, 'newLinkedTargets_string': 'APH1A (ENSG00000117362), PSENEN (ENSG00000205155), APH1B (ENSG00000138613), PSEN1 (ENSG00000080815), NCSTN (ENSG00000162736), PSEN2 (ENSG00000143801)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2667', 'drugName': 'Tarenflurbil', 'drugIsApproved': False, 'newLinkedTargets_string': 'APH1A (ENSG00000117362), PSENEN (ENSG00000205155), APH1B (ENSG00000138613), PSEN1 (ENSG00000080815), NCSTN (ENSG00000162736), PSEN2 (ENSG00000143801)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6335', 'drugName': 'Semagacestat', 'drugIsApproved': False, 'newLinkedTargets_string': 'APH1A (ENSG00000117362), PSENEN (ENSG00000205155), APH1B (ENSG00000138613), PSEN1 (ENSG00000080815), NCSTN (ENSG00000162736), PSEN2 (ENSG00000143801)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5781', 'drugName': 'Avagacestat', 'drugIsApproved': False, 'newLinkedTargets_string': 'APH1A (ENSG00000117362), PSENEN (ENSG00000205155), APH1B (ENSG00000138613), PSEN1 (ENSG00000080815), NCSTN (ENSG00000162736), PSEN2 (ENSG00000143801)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5217', 'drugName': 'Rg-4733', 'drugIsApproved': False, 'newLinkedTargets_string': 'APH1A (ENSG00000117362), PSENEN (ENSG00000205155), APH1B (ENSG00000138613), PSEN1 (ENSG00000080815), NCSTN (ENSG00000162736), PSEN2 (ENSG00000143801)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6270', 'drugName': 'Begacestat', 'drugIsApproved': False, 'newLinkedTargets_string': 'APH1A (ENSG00000117362), PSENEN (ENSG00000205155), APH1B (ENSG00000138613), PSEN1 (ENSG00000080815), NCSTN (ENSG00000162736), PSEN2 (ENSG00000143801)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1118 | Q1 | Is PPP2CA a druggable gene? | There are currently no approved drugs targeting PPP2CA, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PPP2CA %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4335', 'drugName': 'Lb-100', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPP2CA (ENSG00000113575), PPP5C (ENSG00000011485), PPP2CB (ENSG00000104695)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4336', 'drugName': 'Lb-100', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPP2CA (ENSG00000113575), PPP5C (ENSG00000011485), PPP2CB (ENSG00000104695)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4337', 'drugName': 'Lb-100', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPP2CA (ENSG00000113575), PPP5C (ENSG00000011485), PPP2CB (ENSG00000104695)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1038 | Q1 | Is PCSK9 a druggable gene? | There are currently 4 approved drugs which target PCSK9, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PCSK9 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1637', 'drugName': 'Alirocumab', 'drugIsApproved': True, 'newLinkedTargets_string': 'PCSK9 (ENSG00000169174)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4738', 'drugName': 'Inclisiran Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PCSK9 (ENSG00000169174)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_859', 'drugName': 'Inclisiran', 'drugIsApproved': True, 'newLinkedTargets_string': 'PCSK9 (ENSG00000169174)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_646', 'drugName': 'Evolocumab', 'drugIsApproved': True, 'newLinkedTargets_string': 'PCSK9 (ENSG00000169174)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6016', 'drugName': 'Lerodalcibep', 'drugIsApproved': False, 'newLinkedTargets_string': 'PCSK9 (ENSG00000169174)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3659', 'drugName': 'Bococizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'PCSK9 (ENSG00000169174)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3754', 'drugName': 'Ongericimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'PCSK9 (ENSG00000169174)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1622', 'drugName': 'Tafolecimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'PCSK9 (ENSG00000169174)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4159', 'drugName': 'Frovocimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'PCSK9 (ENSG00000169174)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1023', 'drugName': 'Rg-7652', 'drugIsApproved': False, 'newLinkedTargets_string': 'PCSK9 (ENSG00000169174)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4790', 'drugName': 'Ralpancizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'PCSK9 (ENSG00000169174)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1097 | Q1 | Is PMEL a druggable gene? | There is 1 drug, Tebentafusp, that targets PMEL, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PMEL %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5977', 'drugName': 'Tebentafusp', 'drugIsApproved': True, 'newLinkedTargets_string': 'PMEL (ENSG00000185664)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5274', 'drugName': 'Imc-Gp100', 'drugIsApproved': False, 'newLinkedTargets_string': 'PMEL (ENSG00000185664), CD3E (ENSG00000198851), CD3G (ENSG00000160654), CD3D (ENSG00000167286)', 'maxClinicalTrialPhase': -1}, {'UUID': 'DrugGeneTargets_v2_5275', 'drugName': 'Imc-Gp100', 'drugIsApproved': False, 'newLinkedTargets_string': 'PMEL (ENSG00000185664), CD3E (ENSG00000198851), CD3G (ENSG00000160654), CD3D (ENSG00000167286)', 'maxClinicalTrialPhase': -1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
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BiomedSQL
Dataset Summary
BiomedSQL is a text-to-SQL benchmark designed to evaluate Large Language Models (LLMs) on scientific tabular reasoning tasks. It consists of curated question-SQL query-answer triples covering a variety of biomedical and SQL reasoning types. The benchmark challenges models to apply implicit
scientific criteria rather than simply translating syntax.
benchmark_data: contains the question-SQL query-answer triples.
db_data: contains the parquet files needed to recreate the tables in the evaluation database.
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