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NIFD_1_S_0194_MR_T1_mprage_S3_DIS3D_br_raw_20140831195557073_107_S229201_I441537_dupl_2 | On a T1-weighted brain MRI of a 77-year-old female subject, we observed:
For the ventricles:
- no abnormal enlargement observed in the 4th ventricle
- no enlargement observed in the inf. lateral ventricle
- no observable enlargement or abnormal growth in the lateral ventricle
- no signs of enlargement detected in the 3rd ventricle
- mild enlargement of the external csf
For the subcortical structures:
- moderate bilateral putamen atrophy, more pronounced on the right
- between normal and mild right atrophy of the basal forebrain
- thalamus maintains its normal morphology without atrophic features
- no signs of atrophy detected in the hippocampus
- amygdala appears structurally intact with no atrophic changes
- caudate remains normal, with no signs of tissue loss
- no signs of atrophy detected in the pallidum
- no degenerative or atrophic changes noted in the accumbens
- ventral dc maintains its normal morphology without atrophic features
For the cerebral cortex:
- focal atrophy of limbic cortex on entorhinal area (between normal and mild)
- focal atrophy of occipital lobe on calcarine cortex (between normal and mild)
- severe atrophy of the insular cortex, more pronounced on the right, with focal volume loss observed in the following subregions: anterior insula (moderate), central operculum (between moderate and severe), parietal operculum (between moderate and severe) and posterior insula (severe)
- moderate atrophy of the temporal lobe, more pronounced on the right, with focal volume loss observed in the following subregions: planum temporale (between moderate and severe), inf. temporal gyrus (mild) and transverse temporal gyrus (between moderate and severe)
- frontal lobe maintains its normal morphology without atrophic features
- between mild and moderate atrophy of the parietal lobe, more pronounced on the right, with focal volume loss observed in the following subregions: precuneus (mild), sup. parietal lobule (mild) and angular gyrus (mild) | PNFA |
NIFD_1_S_0067_MR_t1_mprage_S6_DIS3D_br_raw_20111209120245536_154_S132398_I270856_dupl_1 | On a T1-weighted brain MRI of a 78-year-old male subject, we observed:
For the subcortical structures:
- no degenerative or atrophic changes noted in the basal forebrain
- between mild and moderate atrophy of the putamen, more pronounced on the left
- severe bilateral amygdala atrophy, more pronounced on the left
- moderate left atrophy of the thalamus
- between normal and mild left atrophy of the ventral dc
- moderate bilateral caudate atrophy, more pronounced on the left
- between mild and moderate atrophy of the pallidum, more pronounced on the left
- between moderate and severe bilateral accumbens atrophy
- between normal and mild atrophy of the hippocampus, more pronounced on the left
For the cerebral cortex:
- focal atrophy of limbic cortex on anterior cingulate gyrus (between normal and mild)
- focal atrophy of temporal lobe on middle temporal gyrus (between mild and moderate)
- atrophies of frontal lobe on orbital inf. frontal gyrus (mild), middle frontal gyrus (between normal and mild), medial orbital gyrus (between normal and mild), posterior orbital gyrus (moderate) and sup. frontal gyrus medial segment (between normal and mild)
- parietal lobe appears structurally intact with no atrophic changes
- focal atrophy of occipital lobe on calcarine cortex (between normal and mild)
- between normal and mild atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: posterior insula (between normal and mild)
For the ventricles:
- mild enlargement of the lateral ventricle
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
- 4th ventricle is free from enlargement or excessive growth
- mild enlargement of the external csf
- moderate enlargement of the 3rd ventricle | PNFA |
NIFD_1_S_0309_MR_t1_mprage__br_raw_20160909134218398_83_S497944_I774495 | On a T1-weighted brain MRI of a 67-year-old male subject, we observed:
For the ventricles:
- external csf is free from enlargement or excessive growth
- no observable enlargement or abnormal growth in the 4th ventricle
- between moderate and severe bilateral inf. lateral ventricle enlargement
- mild enlargement of the 3rd ventricle
- lateral ventricle remains within normal size parameters, with no enlargement detected
For the subcortical structures:
- no observable atrophic alterations in the caudate
- no pathological changes consistent with atrophy detected in the basal forebrain
- putamen appears structurally intact with no atrophic changes
- the amygdala shows no structural abnormalities indicative of atrophy
- the hippocampus shows no structural abnormalities indicative of atrophy
- no evidence of atrophy or degeneration in the ventral dc
- pallidum maintains its normal morphology without atrophic features
- accumbens remains normal, with no signs of tissue loss
- the thalamus shows no structural abnormalities indicative of atrophy
For the cerebral cortex:
- focal atrophy of insular cortex on anterior insula (between mild and moderate)
- focal atrophy of limbic cortex on middle cingulate gyrus (mild)
- atrophies of frontal lobe on triangular inf. frontal gyrus (between normal and mild) and middle frontal gyrus (between normal and mild)
- focal atrophy of occipital lobe on inf. occipital gyrus (mild)
- focal atrophy of parietal lobe on postcentral gyrus (between normal and mild)
- no signs of atrophy detected in the temporal lobe | CN |
NIFD_1_S_0035_MR_t1_mprage_S3_DIS3D_br_raw_20110426104720819_116_S105196_I229033_dupl_1 | On a T1-weighted brain MRI of a 64-year-old female subject, we observed:
For the ventricles:
- severe enlargement of the 3rd ventricle
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
- mild enlargement of the lateral ventricle, more pronounced on the left
- mild enlargement of the 4th ventricle
- severe enlargement of the external csf
For the subcortical structures:
- severe bilateral accumbens atrophy, more pronounced on the left
- moderate atrophy of the putamen, more pronounced on the left
- severe bilateral hippocampus atrophy, more pronounced on the left
- no pathological changes consistent with atrophy detected in the ventral dc
- between normal and mild atrophy of the thalamus, more pronounced on the left
- basal forebrain remains normal, with no signs of tissue loss
- severe bilateral amygdala atrophy, more pronounced on the left
- moderate atrophy of the pallidum, more pronounced on the left
- severe bilateral caudate atrophy, more pronounced on the left
For the cerebral cortex:
- focal atrophy of frontal lobe on gyrus rectus (between normal and mild)
- parietal lobe remains normal, with no signs of tissue loss
- no observable atrophic alterations in the occipital lobe
- between moderate and severe bilateral insular cortex atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (between mild and moderate) and frontal operculum (between normal and mild)
- severe bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: entorhinal area (between moderate and severe), anterior cingulate gyrus (between moderate and severe) and parahippocampal gyrus (severe)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (between moderate and severe), inf. temporal gyrus (severe), middle temporal gyrus (moderate) and temporal pole (moderate) | SV |
ADNI_011_S_4105_MR_MPRAGE_br_raw_20110719125904723_114_S115213_I245491 | On a T1-weighted brain MRI of a 71-year-old female subject, we observed:
For the subcortical structures:
- accumbens remains normal, with no signs of tissue loss
- no degenerative or atrophic changes noted in the pallidum
- thalamus remains normal, with no signs of tissue loss
- putamen appears structurally intact with no atrophic changes
- basal forebrain presents with a healthy appearance, free from atrophy
- no pathological changes consistent with atrophy detected in the ventral dc
- no degenerative or atrophic changes noted in the amygdala
- caudate remains normal, with no signs of tissue loss
- no observable atrophic alterations in the hippocampus
For the cerebral cortex:
- atrophies of frontal lobe on gyrus rectus (between moderate and severe), medial orbital gyrus (between normal and mild) and sup. frontal gyrus medial segment (mild)
- focal atrophy of parietal lobe on supramarginal gyrus (between mild and moderate)
- focal atrophy of occipital lobe on middle occipital gyrus (between normal and mild)
- focal atrophy of limbic cortex on entorhinal area (between normal and mild)
- focal atrophy of insular cortex on central operculum (mild)
- mild atrophy of the temporal lobe, more pronounced on the right, with focal volume loss observed in the following subregions: fusiform gyrus (moderate)
For the ventricles:
- 3rd ventricle appears structurally intact, with no evidence of enlargement
- 4th ventricle remains within normal size parameters, with no enlargement detected
- moderate bilateral lateral ventricle enlargement
- no observable enlargement or abnormal growth in the external csf
- mild enlargement of the inf. lateral ventricle, more pronounced on the left | CN |
NIFD_1_S_0187_MR_T1_mprage_S3_DIS3D_br_raw_20140901073756573_14_S229276_I441619_dupl_4 | On a T1-weighted brain MRI of a 58-year-old female subject, we observed:
For the subcortical structures:
- severe bilateral amygdala atrophy, more pronounced on the left
- between mild and moderate atrophy of the hippocampus, more pronounced on the left
- no degenerative or atrophic changes noted in the ventral dc
- between normal and mild atrophy of the putamen, more pronounced on the left
- no evidence of atrophy or degeneration in the caudate
- thalamus presents with a healthy appearance, free from atrophy
- between mild and moderate atrophy of the accumbens, more pronounced on the left
- no signs of atrophy detected in the pallidum
- basal forebrain presents with a healthy appearance, free from atrophy
For the ventricles:
- between mild and moderate enlargement of the external csf
- lateral ventricle maintains its normal volume without signs of enlargement
- severe enlargement of the 3rd ventricle
- no enlargement observed in the 4th ventricle
- severe enlargement of the inf. lateral ventricle, more pronounced on the left
For the cerebral cortex:
- occipital lobe presents with a healthy appearance, free from atrophy
- focal atrophy of insular cortex on anterior insula (between mild and moderate)
- severe atrophy of the temporal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: inf. temporal gyrus (between mild and moderate), temporal pole (severe) and middle temporal gyrus (between moderate and severe)
- focal atrophy of frontal lobe on gyrus rectus (between normal and mild)
- focal atrophy of parietal lobe on supramarginal gyrus (mild)
- limbic cortex appears structurally intact with no atrophic changes | SV |
NIFD_1_S_0032_MR_t1_mprage_S41_DIS3D__br_raw_20110514204129592_155_S108946_I235070 | On a T1-weighted brain MRI of a 60-year-old male subject, we observed:
For the subcortical structures:
- between moderate and severe bilateral accumbens atrophy, more pronounced on the left
- mild atrophy of the hippocampus, more pronounced on the left
- moderate bilateral amygdala atrophy, more pronounced on the left
- between normal and mild atrophy of the putamen, more pronounced on the left
- between mild and moderate atrophy of the thalamus, more pronounced on the left
- basal forebrain maintains its normal morphology without atrophic features
- between moderate and severe bilateral pallidum atrophy, more pronounced on the left
- mild left atrophy of the caudate
- moderate bilateral ventral dc atrophy, more pronounced on the left
For the cerebral cortex:
- severe bilateral frontal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: opercular inf. frontal gyrus (mild), middle frontal gyrus (severe), posterior orbital gyrus (mild), precentral gyrus (between moderate and severe) and orbital inf. frontal gyrus (between normal and mild)
- between mild and moderate atrophy of the insular cortex, with focal volume loss observed in the following subregions: anterior insula (severe) and frontal operculum (between normal and mild)
- focal atrophy of occipital lobe on cuneus (moderate)
- between mild and moderate atrophy of the limbic cortex, with focal volume loss observed in the following subregions: anterior cingulate gyrus (between moderate and severe) and middle cingulate gyrus (mild)
- focal atrophy of temporal lobe on temporal pole (between moderate and severe)
- no evidence of atrophy or degeneration in the parietal lobe
For the ventricles:
- 3rd ventricle appears structurally intact, with no evidence of enlargement
- 4th ventricle maintains its normal volume without signs of enlargement
- severe enlargement of the external csf
- between normal and mild enlargement of the lateral ventricle
- mild left enlargement of the inf. lateral ventricle | BV |
NIFD_1_S_0072_MR_T1_mprage_S3_DIS3D_br_raw_20170816175300325_153_S597008_I890174 | On a T1-weighted brain MRI of a 69-year-old male subject, we observed:
For the subcortical structures:
- between normal and mild atrophy of the pallidum, more pronounced on the left
- severe bilateral accumbens atrophy, more pronounced on the left
- between normal and mild atrophy of the thalamus, more pronounced on the left
- severe bilateral amygdala atrophy, more pronounced on the left
- the caudate shows no structural abnormalities indicative of atrophy
- moderate atrophy of the putamen, more pronounced on the left
- no signs of atrophy detected in the basal forebrain
- severe bilateral hippocampus atrophy, more pronounced on the left
- ventral dc appears structurally intact with no atrophic changes
For the ventricles:
- no enlargement observed in the 4th ventricle
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
- no pathological changes consistent with enlargement noted in the 3rd ventricle
- between moderate and severe enlargement of the external csf
- no enlargement observed in the lateral ventricle
For the cerebral cortex:
- severe bilateral insular cortex atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (moderate) and parietal operculum (between mild and moderate)
- atrophies of frontal lobe on posterior orbital gyrus (moderate) and sup. frontal gyrus medial segment (mild)
- atrophies of limbic cortex on entorhinal area (severe) and parahippocampal gyrus (severe)
- no degenerative or atrophic changes noted in the parietal lobe
- occipital lobe maintains its normal morphology without atrophic features
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (between moderate and severe), planum temporale (between moderate and severe), inf. temporal gyrus (severe), middle temporal gyrus (severe), sup. temporal gyrus (between mild and moderate) and temporal pole (severe) | SV |
NIFD_1_S_0050_MR_T1_MPRAGE_long_S2_DIS3D__br_raw_20110718081422479_31_S115040_I245234_dupl_10 | On a T1-weighted brain MRI of a 75-year-old female subject, we observed:
For the subcortical structures:
- between moderate and severe bilateral caudate atrophy, more pronounced on the right
- severe bilateral putamen atrophy, more pronounced on the right
- moderate bilateral accumbens atrophy
- between moderate and severe bilateral pallidum atrophy, more pronounced on the right
- hippocampus remains normal, with no signs of tissue loss
- between moderate and severe bilateral ventral dc atrophy, more pronounced on the right
- no signs of atrophy detected in the basal forebrain
- severe bilateral amygdala atrophy, more pronounced on the right
- thalamus appears structurally intact with no atrophic changes
For the ventricles:
- no observable enlargement or abnormal growth in the lateral ventricle
- severe enlargement of the external csf
- no pathological changes consistent with enlargement noted in the 3rd ventricle
- 4th ventricle maintains its normal volume without signs of enlargement
- no abnormal enlargement observed in the inf. lateral ventricle
For the cerebral cortex:
- occipital lobe remains normal, with no signs of tissue loss
- severe bilateral frontal lobe atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: middle frontal gyrus (mild), anterior orbital gyrus (mild), precentral gyrus (severe), sup. frontal gyrus (mild), supplementary motor cortex (severe) and precentral gyrus medial segment (mild)
- between moderate and severe bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: entorhinal area (mild), anterior cingulate gyrus (mild), middle cingulate gyrus (mild) and parahippocampal gyrus (moderate)
- focal atrophy of parietal lobe on supramarginal gyrus (between normal and mild)
- between mild and moderate atrophy of the temporal lobe, more pronounced on the right, with focal volume loss observed in the following subregions: fusiform gyrus (between moderate and severe) and temporal pole (mild)
- severe bilateral insular cortex atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (moderate) and central operculum (moderate) | PNFA |
NIFD_1_S_0032_MR_t1_mprage_S41_DIS3D__br_raw_20110514204129592_155_S108946_I235070_dupl_2 | On a T1-weighted brain MRI of a 60-year-old male subject, we observed:
For the ventricles:
- mild left enlargement of the inf. lateral ventricle
- no observable enlargement or abnormal growth in the 3rd ventricle
- between normal and mild enlargement of the lateral ventricle
- 4th ventricle remains within normal size parameters, with no enlargement detected
- severe enlargement of the external csf
For the cerebral cortex:
- severe bilateral frontal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: opercular inf. frontal gyrus (mild), middle frontal gyrus (severe), posterior orbital gyrus (mild), precentral gyrus (between moderate and severe) and orbital inf. frontal gyrus (between normal and mild)
- between mild and moderate atrophy of the insular cortex, with focal volume loss observed in the following subregions: anterior insula (severe) and frontal operculum (between normal and mild)
- focal atrophy of occipital lobe on cuneus (moderate)
- focal atrophy of temporal lobe on temporal pole (between moderate and severe)
- parietal lobe appears structurally intact with no atrophic changes
- between mild and moderate atrophy of the limbic cortex, with focal volume loss observed in the following subregions: anterior cingulate gyrus (between moderate and severe) and middle cingulate gyrus (mild)
For the subcortical structures:
- mild atrophy of the hippocampus, more pronounced on the left
- basal forebrain maintains its normal morphology without atrophic features
- moderate bilateral ventral dc atrophy, more pronounced on the left
- between moderate and severe bilateral pallidum atrophy, more pronounced on the left
- between mild and moderate atrophy of the thalamus, more pronounced on the left
- mild left atrophy of the caudate
- moderate bilateral amygdala atrophy, more pronounced on the left
- between moderate and severe bilateral accumbens atrophy, more pronounced on the left
- between normal and mild atrophy of the putamen, more pronounced on the left | BV |
ADNI_135_S_4446_MR_MPRAGE_br_raw_20120117112205836_47_S136801_I278378 | On a T1-weighted brain MRI of a 69-year-old female subject, we observed:
For the cerebral cortex:
- parietal lobe presents with a healthy appearance, free from atrophy
- focal atrophy of occipital lobe on occipital pole (between normal and mild)
- no degenerative or atrophic changes noted in the temporal lobe
- between mild and moderate bilateral frontal lobe atrophy, with focal volume loss observed in the following subregions: frontal pole (between mild and moderate) and middle frontal gyrus (between moderate and severe)
- no signs of atrophy detected in the limbic cortex
- no signs of atrophy detected in the insular cortex
For the subcortical structures:
- no evidence of atrophy or degeneration in the basal forebrain
- thalamus appears structurally intact with no atrophic changes
- no evidence of atrophy or degeneration in the hippocampus
- no degenerative or atrophic changes noted in the putamen
- accumbens presents with a healthy appearance, free from atrophy
- amygdala presents with a healthy appearance, free from atrophy
- caudate appears structurally intact with no atrophic changes
- no signs of atrophy detected in the pallidum
- ventral dc presents with a healthy appearance, free from atrophy
For the ventricles:
- between normal and mild enlargement of the external csf
- no enlargement observed in the inf. lateral ventricle
- lateral ventricle appears structurally intact, with no evidence of enlargement
- 3rd ventricle remains within normal size parameters, with no enlargement detected
- no enlargement observed in the 4th ventricle | CN |
ADNI_011_S_4827_MR_MPRAGE_br_raw_20120703085506250_153_S156389_I314042_dupl_1 | On a T1-weighted brain MRI of a 72-year-old male subject, we observed:
For the subcortical structures:
- between mild and moderate left atrophy of the thalamus
- caudate appears structurally intact with no atrophic changes
- severe bilateral amygdala atrophy, more pronounced on the left
- no pathological changes consistent with atrophy detected in the basal forebrain
- mild left atrophy of the hippocampus
- no signs of atrophy detected in the ventral dc
- the accumbens shows no structural abnormalities indicative of atrophy
- no pathological changes consistent with atrophy detected in the pallidum
- between mild and moderate left atrophy of the putamen
For the cerebral cortex:
- mild atrophy of the frontal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: opercular inf. frontal gyrus (between mild and moderate)
- atrophies of insular cortex on central operculum (between normal and mild) and frontal operculum (between normal and mild)
- temporal lobe maintains its normal morphology without atrophic features
- between normal and mild atrophy of the parietal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: postcentral gyrus (mild) and postcentral gyrus medial segment (between moderate and severe)
- focal atrophy of occipital lobe on occipital fusiform gyrus (between normal and mild)
- mild atrophy of the limbic cortex
For the ventricles:
- inf. lateral ventricle appears structurally intact, with no evidence of enlargement
- no observable enlargement or abnormal growth in the 3rd ventricle
- the 4th ventricle shows no structural abnormalities indicative of enlargement
- severe enlargement of the external csf
- lateral ventricle maintains its normal volume without signs of enlargement | AD |
NIFD_1_S_0015_MR_t1_mprage_S3_DIS3D_br_raw_20110204144009602_54_S99058_I215997_dupl_7 | On a T1-weighted brain MRI of a 63-year-old male subject, we observed:
For the ventricles:
- severe enlargement of the 3rd ventricle
- no signs of enlargement detected in the 4th ventricle
- no observable enlargement or abnormal growth in the lateral ventricle
- between moderate and severe enlargement of the external csf
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
For the subcortical structures:
- moderate bilateral accumbens atrophy, more pronounced on the left
- no observable atrophic alterations in the thalamus
- between normal and mild left atrophy of the pallidum
- no evidence of atrophy or degeneration in the caudate
- severe bilateral amygdala atrophy, more pronounced on the left
- basal forebrain appears structurally intact with no atrophic changes
- between moderate and severe left atrophy of the putamen
- severe atrophy of the hippocampus, more pronounced on the left
- ventral dc presents with a healthy appearance, free from atrophy
For the cerebral cortex:
- occipital lobe presents with a healthy appearance, free from atrophy
- focal atrophy of parietal lobe on postcentral gyrus medial segment (moderate)
- severe bilateral insular cortex atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (between moderate and severe) and frontal operculum (between normal and mild)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (severe), planum polare (moderate), inf. temporal gyrus (between moderate and severe), middle temporal gyrus (mild), sup. temporal gyrus (moderate) and temporal pole (severe)
- mild atrophy of the frontal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: anterior orbital gyrus (between normal and mild) and sup. frontal gyrus medial segment (moderate)
- moderate bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: entorhinal area (severe) | SV |
ADNI_032_S_4348_MR_MPRAGE_br_raw_20111118112458497_150_S130131_I267561 | On a T1-weighted brain MRI of a 67-year-old female subject, we observed:
For the subcortical structures:
- no evidence of atrophy or degeneration in the hippocampus
- pallidum appears structurally intact with no atrophic changes
- no signs of atrophy detected in the putamen
- caudate presents with a healthy appearance, free from atrophy
- accumbens presents with a healthy appearance, free from atrophy
- basal forebrain remains normal, with no signs of tissue loss
- no signs of atrophy detected in the ventral dc
- thalamus presents with a healthy appearance, free from atrophy
- amygdala appears structurally intact with no atrophic changes
For the ventricles:
- inf. lateral ventricle maintains its normal volume without signs of enlargement
- the lateral ventricle shows no structural abnormalities indicative of enlargement
- 4th ventricle appears structurally intact, with no evidence of enlargement
- moderate enlargement of the external csf
- 3rd ventricle maintains its normal volume without signs of enlargement
For the cerebral cortex:
- between moderate and severe bilateral frontal lobe atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: orbital inf. frontal gyrus (between normal and mild), middle frontal gyrus (severe), precentral gyrus (mild), subcallosal area (between mild and moderate) and gyrus rectus (between normal and mild)
- between normal and mild atrophy of the limbic cortex
- between normal and mild atrophy of the insular cortex
- atrophies of temporal lobe on fusiform gyrus (moderate) and inf. temporal gyrus (between normal and mild)
- between mild and moderate bilateral occipital lobe atrophy, with focal volume loss observed in the following subregions: lingual gyrus (between normal and mild), sup. occipital gyrus (moderate) and occipital pole (between normal and mild)
- between mild and moderate bilateral parietal lobe atrophy, with focal volume loss observed in the following subregions: postcentral gyrus (between mild and moderate), sup. parietal lobule (mild) and supramarginal gyrus (between normal and mild) | CN |
NIFD_2_S_0032_MR_MT1__GradWarp__N3m_Br_20130613083444087_S191547_I376358 | On a T1-weighted brain MRI of a 58-year-old male subject, we observed:
For the cerebral cortex:
- no signs of atrophy detected in the parietal lobe
- focal atrophy of temporal lobe on inf. temporal gyrus (mild)
- frontal lobe remains normal, with no signs of tissue loss
- no evidence of atrophy or degeneration in the limbic cortex
- focal atrophy of insular cortex on parietal operculum (between normal and mild)
- focal atrophy of occipital lobe on sup. occipital gyrus (between mild and moderate)
For the subcortical structures:
- accumbens maintains its normal morphology without atrophic features
- thalamus remains normal, with no signs of tissue loss
- mild atrophy of the amygdala
- pallidum appears structurally intact with no atrophic changes
- no observable atrophic alterations in the ventral dc
- no signs of atrophy detected in the caudate
- no evidence of atrophy or degeneration in the basal forebrain
- no pathological changes consistent with atrophy detected in the putamen
- between moderate and severe bilateral hippocampus atrophy
For the ventricles:
- inf. lateral ventricle remains within normal size parameters, with no enlargement detected
- the lateral ventricle shows no structural abnormalities indicative of enlargement
- 4th ventricle appears structurally intact, with no evidence of enlargement
- moderate enlargement of the external csf
- no observable enlargement or abnormal growth in the 3rd ventricle | BV |
NIFD_2_S_0014_MR_MT1__GradWarp__N3m_Br_20111229191004875_S134530_I274739_dupl_1 | On a T1-weighted brain MRI of a 53-year-old male subject, we observed:
For the subcortical structures:
- ventral dc appears structurally intact with no atrophic changes
- between normal and mild atrophy of the thalamus
- moderate bilateral amygdala atrophy
- severe bilateral accumbens atrophy, more pronounced on the left
- between normal and mild right atrophy of the hippocampus
- severe bilateral caudate atrophy
- between moderate and severe bilateral putamen atrophy
- no signs of atrophy detected in the basal forebrain
- severe bilateral pallidum atrophy
For the ventricles:
- severe enlargement of the 4th ventricle
- severe bilateral lateral ventricle enlargement
- severe enlargement of the external csf
- severe bilateral inf. lateral ventricle enlargement
- moderate enlargement of the 3rd ventricle
For the cerebral cortex:
- severe bilateral insular cortex atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: anterior insula (between moderate and severe), central operculum (between moderate and severe) and parietal operculum (between normal and mild)
- severe bilateral parietal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: angular gyrus (between normal and mild), precuneus (between normal and mild), sup. parietal lobule (between moderate and severe) and supramarginal gyrus (moderate)
- between normal and mild atrophy of the temporal lobe, more pronounced on the right, with focal volume loss observed in the following subregions: sup. temporal gyrus (between mild and moderate) and temporal pole (mild)
- between normal and mild atrophy of the limbic cortex, with focal volume loss observed in the following subregions: anterior cingulate gyrus (between mild and moderate)
- atrophies of occipital lobe on cuneus (between mild and moderate) and middle occipital gyrus (between mild and moderate)
- severe bilateral frontal lobe atrophy, with focal volume loss observed in the following subregions: gyrus rectus (between mild and moderate), opercular inf. frontal gyrus (between normal and mild), middle frontal gyrus (between mild and moderate), lateral orbital gyrus (mild), posterior orbital gyrus (severe) and sup. frontal gyrus (between mild and moderate) | BV |
ADNI_009_S_5224_MR_MPRAGE_br_raw_20130717152112089_161_S195460_I381184_dupl_1 | On a T1-weighted brain MRI of a 79-year-old male subject, we observed:
For the cerebral cortex:
- focal atrophy of occipital lobe on inf. occipital gyrus (between mild and moderate)
- between mild and moderate atrophy of the insular cortex, more pronounced on the right, with focal volume loss observed in the following subregions: posterior insula (mild), central operculum (between normal and mild) and frontal operculum (between normal and mild)
- the parietal lobe shows no structural abnormalities indicative of atrophy
- moderate atrophy of the temporal lobe, more pronounced on the right, with focal volume loss observed in the following subregions: middle temporal gyrus (moderate) and temporal pole (severe)
- moderate atrophy of the limbic cortex, with focal volume loss observed in the following subregions: entorhinal area (severe) and parahippocampal gyrus (between moderate and severe)
- atrophies of frontal lobe on anterior orbital gyrus (mild) and precentral gyrus medial segment (mild)
For the ventricles:
- no abnormal enlargement observed in the lateral ventricle
- moderate enlargement of the inf. lateral ventricle, more pronounced on the right
- no enlargement observed in the 4th ventricle
- between normal and mild enlargement of the external csf
- no enlargement observed in the 3rd ventricle
For the subcortical structures:
- severe bilateral amygdala atrophy, more pronounced on the right
- the thalamus shows no structural abnormalities indicative of atrophy
- between normal and mild atrophy of the ventral dc
- accumbens appears structurally intact with no atrophic changes
- basal forebrain presents with a healthy appearance, free from atrophy
- moderate bilateral hippocampus atrophy
- pallidum remains normal, with no signs of tissue loss
- no observable atrophic alterations in the caudate
- no observable atrophic alterations in the putamen | AD |
NIFD_1_S_0064_MR_t1_mprage_S3_DIS3D_br_raw_20111019180821812_6_S125843_I261660_dupl_1 | On a T1-weighted brain MRI of a 66-year-old female subject, we observed:
For the ventricles:
- no observable enlargement or abnormal growth in the external csf
- between moderate and severe enlargement of the 3rd ventricle
- moderate bilateral lateral ventricle enlargement
- 4th ventricle maintains its normal volume without signs of enlargement
- mild enlargement of the inf. lateral ventricle, more pronounced on the left
For the subcortical structures:
- hippocampus presents with a healthy appearance, free from atrophy
- mild right atrophy of the pallidum
- between normal and mild atrophy of the accumbens, more pronounced on the right
- ventral dc maintains its normal morphology without atrophic features
- no pathological changes consistent with atrophy detected in the amygdala
- moderate bilateral putamen atrophy
- no pathological changes consistent with atrophy detected in the thalamus
- between normal and mild left atrophy of the basal forebrain
- mild right atrophy of the caudate
For the cerebral cortex:
- between normal and mild atrophy of the frontal lobe, more pronounced on the right, with focal volume loss observed in the following subregions: sup. frontal gyrus (between moderate and severe), sup. frontal gyrus medial segment (between moderate and severe) and precentral gyrus (mild)
- focal atrophy of limbic cortex on middle cingulate gyrus (between normal and mild)
- between normal and mild atrophy of the insular cortex
- atrophies of temporal lobe on planum temporale (mild) and temporal pole (between normal and mild)
- occipital lobe remains normal, with no signs of tissue loss
- parietal lobe maintains its normal morphology without atrophic features | BV |
NIFD_1_S_0127_MR_T1_mprage_S3_DIS3D_br_raw_20170817113930950_131_S597781_I891241_dupl_7 | On a T1-weighted brain MRI of a 61-year-old male subject, we observed:
For the cerebral cortex:
- severe bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: entorhinal area (severe), anterior cingulate gyrus (moderate) and parahippocampal gyrus (severe)
- no degenerative or atrophic changes noted in the parietal lobe
- between mild and moderate atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (between moderate and severe) and posterior insula (severe)
- atrophies of occipital lobe on calcarine cortex (mild), occipital fusiform gyrus (moderate) and inf. occipital gyrus (between normal and mild)
- atrophies of frontal lobe on gyrus rectus (between mild and moderate), orbital inf. frontal gyrus (mild) and triangular inf. frontal gyrus (between normal and mild)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (severe), inf. temporal gyrus (mild), middle temporal gyrus (between mild and moderate), sup. temporal gyrus (mild) and temporal pole (severe)
For the subcortical structures:
- ventral dc maintains its normal morphology without atrophic features
- between mild and moderate atrophy of the putamen, more pronounced on the left
- between mild and moderate left atrophy of the thalamus
- basal forebrain remains normal, with no signs of tissue loss
- no pathological changes consistent with atrophy detected in the pallidum
- caudate remains normal, with no signs of tissue loss
- mild bilateral accumbens atrophy
- severe bilateral amygdala atrophy, more pronounced on the left
- severe bilateral hippocampus atrophy, more pronounced on the left
For the ventricles:
- 3rd ventricle is free from enlargement or excessive growth
- no signs of enlargement detected in the lateral ventricle
- moderate enlargement of the external csf
- 4th ventricle maintains its normal volume without signs of enlargement
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left | SV |
NIFD_1_S_0100_MR_T1_mprage_S3_DIS3D_br_raw_20120830090711252_25_S164010_I327985_dupl_2 | On a T1-weighted brain MRI of a 73-year-old female subject, we observed:
For the ventricles:
- severe enlargement of the inf. lateral ventricle, more pronounced on the left
- no observable enlargement or abnormal growth in the 4th ventricle
- the external csf shows no structural abnormalities indicative of enlargement
- lateral ventricle maintains its normal volume without signs of enlargement
- the 3rd ventricle shows no structural abnormalities indicative of enlargement
For the subcortical structures:
- thalamus maintains its normal morphology without atrophic features
- no observable atrophic alterations in the ventral dc
- moderate atrophy of the accumbens, more pronounced on the left
- between normal and mild left atrophy of the caudate
- no pathological changes consistent with atrophy detected in the basal forebrain
- severe bilateral amygdala atrophy, more pronounced on the left
- between mild and moderate atrophy of the putamen, more pronounced on the left
- between normal and mild atrophy of the pallidum, more pronounced on the left
- severe atrophy of the hippocampus, more pronounced on the left
For the cerebral cortex:
- atrophies of limbic cortex on parahippocampal gyrus (mild) and entorhinal area (between mild and moderate)
- atrophies of frontal lobe on gyrus rectus (mild) and supplementary motor cortex (between normal and mild)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (severe), temporal pole (severe), inf. temporal gyrus (moderate), planum polare (mild) and middle temporal gyrus (between normal and mild)
- occipital lobe presents with a healthy appearance, free from atrophy
- no degenerative or atrophic changes noted in the parietal lobe
- no pathological changes consistent with atrophy detected in the insular cortex | SV |
NIFD_1_S_0050_MR_T1_MPRAGE_long_S2_DIS3D__br_raw_20110718081422479_31_S115040_I245234_dupl_1 | On a T1-weighted brain MRI of a 75-year-old female subject, we observed:
For the ventricles:
- no signs of enlargement detected in the lateral ventricle
- no pathological changes consistent with enlargement noted in the inf. lateral ventricle
- the 3rd ventricle shows no structural abnormalities indicative of enlargement
- severe enlargement of the external csf
- no observable enlargement or abnormal growth in the 4th ventricle
For the cerebral cortex:
- between mild and moderate atrophy of the temporal lobe, more pronounced on the right, with focal volume loss observed in the following subregions: fusiform gyrus (between moderate and severe) and temporal pole (mild)
- severe bilateral insular cortex atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (moderate) and central operculum (moderate)
- focal atrophy of parietal lobe on supramarginal gyrus (between normal and mild)
- severe bilateral frontal lobe atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: middle frontal gyrus (mild), anterior orbital gyrus (mild), precentral gyrus (severe), sup. frontal gyrus (mild), supplementary motor cortex (severe) and precentral gyrus medial segment (mild)
- between moderate and severe bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: entorhinal area (mild), anterior cingulate gyrus (mild), middle cingulate gyrus (mild) and parahippocampal gyrus (moderate)
- no evidence of atrophy or degeneration in the occipital lobe
For the subcortical structures:
- severe bilateral putamen atrophy, more pronounced on the right
- no pathological changes consistent with atrophy detected in the hippocampus
- between moderate and severe bilateral caudate atrophy, more pronounced on the right
- basal forebrain presents with a healthy appearance, free from atrophy
- the thalamus shows no structural abnormalities indicative of atrophy
- between moderate and severe bilateral pallidum atrophy, more pronounced on the right
- severe bilateral amygdala atrophy, more pronounced on the right
- moderate bilateral accumbens atrophy
- between moderate and severe bilateral ventral dc atrophy, more pronounced on the right | PNFA |
NIFD_1_S_0051_MR_t1_mprage_S3_DIS3D_br_raw_20110718094134503_20_S115066_I245269_dupl_3 | On a T1-weighted brain MRI of a 68-year-old male subject, we observed:
For the cerebral cortex:
- focal atrophy of parietal lobe on sup. parietal lobule (between moderate and severe)
- mild atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (between mild and moderate) and posterior insula (between moderate and severe)
- between normal and mild atrophy of the limbic cortex, with focal volume loss observed in the following subregions: entorhinal area (severe) and parahippocampal gyrus (moderate)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (between mild and moderate), planum polare (between moderate and severe), inf. temporal gyrus (severe), middle temporal gyrus (severe), temporal pole (severe) and sup. temporal gyrus (mild)
- no observable atrophic alterations in the occipital lobe
- focal atrophy of frontal lobe on triangular inf. frontal gyrus (between normal and mild)
For the ventricles:
- mild enlargement of the external csf
- 3rd ventricle appears structurally intact, with no evidence of enlargement
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
- 4th ventricle remains within normal size parameters, with no enlargement detected
- between mild and moderate bilateral lateral ventricle enlargement
For the subcortical structures:
- severe bilateral hippocampus atrophy
- moderate atrophy of the pallidum, more pronounced on the left
- between normal and mild bilateral ventral dc atrophy
- severe bilateral amygdala atrophy, more pronounced on the left
- between moderate and severe bilateral thalamus atrophy, more pronounced on the left
- severe bilateral putamen atrophy, more pronounced on the left
- basal forebrain remains normal, with no signs of tissue loss
- moderate bilateral accumbens atrophy
- between mild and moderate atrophy of the caudate, more pronounced on the left | SV |
NIFD_1_S_0100_MR_T1_mprage_S3_DIS3D_br_raw_20120830090711252_25_S164010_I327985_dupl_4 | On a T1-weighted brain MRI of a 73-year-old female subject, we observed:
For the subcortical structures:
- between mild and moderate atrophy of the putamen, more pronounced on the left
- ventral dc appears structurally intact with no atrophic changes
- between normal and mild left atrophy of the caudate
- severe atrophy of the hippocampus, more pronounced on the left
- between normal and mild atrophy of the pallidum, more pronounced on the left
- severe bilateral amygdala atrophy, more pronounced on the left
- no observable atrophic alterations in the basal forebrain
- no pathological changes consistent with atrophy detected in the thalamus
- moderate atrophy of the accumbens, more pronounced on the left
For the cerebral cortex:
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (severe), temporal pole (severe), inf. temporal gyrus (moderate), planum polare (mild) and middle temporal gyrus (between normal and mild)
- parietal lobe maintains its normal morphology without atrophic features
- atrophies of frontal lobe on gyrus rectus (mild) and supplementary motor cortex (between normal and mild)
- the insular cortex shows no structural abnormalities indicative of atrophy
- no pathological changes consistent with atrophy detected in the occipital lobe
- atrophies of limbic cortex on parahippocampal gyrus (mild) and entorhinal area (between mild and moderate)
For the ventricles:
- no signs of enlargement detected in the 4th ventricle
- lateral ventricle maintains its normal volume without signs of enlargement
- no enlargement observed in the external csf
- no abnormal enlargement observed in the 3rd ventricle
- severe enlargement of the inf. lateral ventricle, more pronounced on the left | SV |
NIFD_3_S_0012_MR_T1_mprage_S3_DIS3D_br_raw_20160520111537809_160_S212086_I413590_dupl_2 | On a T1-weighted brain MRI of a 64-year-old male subject, we observed:
For the cerebral cortex:
- no observable atrophic alterations in the occipital lobe
- no pathological changes consistent with atrophy detected in the parietal lobe
- mild atrophy of the limbic cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior cingulate gyrus (moderate)
- between moderate and severe atrophy of the frontal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: frontal pole (between moderate and severe), gyrus rectus (between normal and mild), opercular inf. frontal gyrus (moderate), orbital inf. frontal gyrus (between moderate and severe), middle frontal gyrus (mild), lateral orbital gyrus (moderate) and sup. frontal gyrus medial segment (between normal and mild)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: inf. temporal gyrus (mild), middle temporal gyrus (moderate), temporal pole (severe) and fusiform gyrus (between normal and mild)
- severe bilateral insular cortex atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe), frontal operculum (between moderate and severe) and parietal operculum (between moderate and severe)
For the subcortical structures:
- moderate atrophy of the amygdala, more pronounced on the left
- no observable atrophic alterations in the thalamus
- between normal and mild left atrophy of the hippocampus
- caudate remains normal, with no signs of tissue loss
- no degenerative or atrophic changes noted in the basal forebrain
- mild left atrophy of the putamen
- accumbens appears structurally intact with no atrophic changes
- no signs of atrophy detected in the pallidum
- no degenerative or atrophic changes noted in the ventral dc
For the ventricles:
- no enlargement observed in the 4th ventricle
- no enlargement observed in the lateral ventricle
- between normal and mild enlargement of the external csf
- 3rd ventricle appears structurally intact, with no evidence of enlargement
- between mild and moderate bilateral inf. lateral ventricle enlargement | PNFA |
NIFD_2_S_0032_MR_MT1__GradWarp__N3m_Br_20130613083444087_S191547_I376358_dupl_1 | On a T1-weighted brain MRI of a 58-year-old male subject, we observed:
For the cerebral cortex:
- focal atrophy of insular cortex on parietal operculum (between normal and mild)
- focal atrophy of occipital lobe on sup. occipital gyrus (between mild and moderate)
- the parietal lobe shows no structural abnormalities indicative of atrophy
- frontal lobe presents with a healthy appearance, free from atrophy
- limbic cortex appears structurally intact with no atrophic changes
- focal atrophy of temporal lobe on inf. temporal gyrus (mild)
For the ventricles:
- no pathological changes consistent with enlargement noted in the 3rd ventricle
- inf. lateral ventricle appears structurally intact, with no evidence of enlargement
- no observable enlargement or abnormal growth in the lateral ventricle
- moderate enlargement of the external csf
- 4th ventricle maintains its normal volume without signs of enlargement
For the subcortical structures:
- thalamus remains normal, with no signs of tissue loss
- mild atrophy of the amygdala
- the ventral dc shows no structural abnormalities indicative of atrophy
- no pathological changes consistent with atrophy detected in the basal forebrain
- no evidence of atrophy or degeneration in the pallidum
- no evidence of atrophy or degeneration in the caudate
- between moderate and severe bilateral hippocampus atrophy
- putamen presents with a healthy appearance, free from atrophy
- no observable atrophic alterations in the accumbens | BV |
NIFD_1_S_0311_MR_T1_mprage_S3_DIS3D_br_raw_20160909141022230_61_S498005_I774570 | On a T1-weighted brain MRI of a 75-year-old male subject, we observed:
For the cerebral cortex:
- severe bilateral parietal lobe atrophy, with focal volume loss observed in the following subregions: postcentral gyrus (moderate) and supramarginal gyrus (between normal and mild)
- no evidence of atrophy or degeneration in the occipital lobe
- between normal and mild atrophy of the insular cortex
- no pathological changes consistent with atrophy detected in the limbic cortex
- temporal lobe maintains its normal morphology without atrophic features
- focal atrophy of frontal lobe on medial frontal cortex (between normal and mild)
For the ventricles:
- no observable enlargement or abnormal growth in the external csf
- mild bilateral inf. lateral ventricle enlargement
- mild enlargement of the 3rd ventricle
- severe enlargement of the 4th ventricle
- severe bilateral lateral ventricle enlargement
For the subcortical structures:
- moderate bilateral thalamus atrophy, more pronounced on the left
- no signs of atrophy detected in the ventral dc
- pallidum presents with a healthy appearance, free from atrophy
- moderate bilateral putamen atrophy
- hippocampus appears structurally intact with no atrophic changes
- amygdala remains normal, with no signs of tissue loss
- caudate maintains its normal morphology without atrophic features
- accumbens presents with a healthy appearance, free from atrophy
- basal forebrain maintains its normal morphology without atrophic features | CN |
ADNI_123_S_4526_MR_MPRAGE_br_raw_20120209093528861_37_S140267_I283603_dupl_2 | On a T1-weighted brain MRI of a 80-year-old male subject, we observed:
For the subcortical structures:
- severe bilateral amygdala atrophy, more pronounced on the left
- accumbens maintains its normal morphology without atrophic features
- no observable atrophic alterations in the thalamus
- putamen maintains its normal morphology without atrophic features
- no observable atrophic alterations in the pallidum
- basal forebrain appears structurally intact with no atrophic changes
- the ventral dc shows no structural abnormalities indicative of atrophy
- moderate atrophy of the hippocampus, more pronounced on the left
- no observable atrophic alterations in the caudate
For the cerebral cortex:
- focal atrophy of temporal lobe on sup. temporal gyrus (between normal and mild)
- frontal lobe presents with a healthy appearance, free from atrophy
- no pathological changes consistent with atrophy detected in the limbic cortex
- insular cortex presents with a healthy appearance, free from atrophy
- the parietal lobe shows no structural abnormalities indicative of atrophy
- occipital lobe remains normal, with no signs of tissue loss
For the ventricles:
- 4th ventricle maintains its normal volume without signs of enlargement
- between normal and mild left enlargement of the inf. lateral ventricle
- no observable enlargement or abnormal growth in the 3rd ventricle
- lateral ventricle appears structurally intact, with no evidence of enlargement
- external csf maintains its normal volume without signs of enlargement | AD |
NIFD_1_S_0347_MR_T1_mprage_S17_DIS3D__br_raw_20170629034809877_28_S578320_I868238_dupl_10 | On a T1-weighted brain MRI of a 61-year-old female subject, we observed:
For the cerebral cortex:
- severe bilateral limbic cortex atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: entorhinal area (between moderate and severe), anterior cingulate gyrus (severe) and parahippocampal gyrus (between normal and mild)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (severe), planum polare (moderate), inf. temporal gyrus (severe), middle temporal gyrus (between moderate and severe) and temporal pole (severe)
- focal atrophy of parietal lobe on precuneus (between normal and mild)
- moderate atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (mild) and frontal operculum (between normal and mild)
- mild atrophy of the frontal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: middle frontal gyrus (between mild and moderate), anterior orbital gyrus (mild) and sup. frontal gyrus medial segment (between normal and mild)
- between moderate and severe bilateral occipital lobe atrophy, with focal volume loss observed in the following subregions: calcarine cortex (moderate), cuneus (between moderate and severe), occipital fusiform gyrus (between normal and mild) and lingual gyrus (between normal and mild)
For the ventricles:
- between moderate and severe bilateral lateral ventricle enlargement
- no signs of enlargement detected in the 3rd ventricle
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
- severe enlargement of the external csf
- no abnormal enlargement observed in the 4th ventricle
For the subcortical structures:
- moderate bilateral thalamus atrophy, more pronounced on the left
- mild left atrophy of the pallidum
- no pathological changes consistent with atrophy detected in the ventral dc
- severe bilateral putamen atrophy, more pronounced on the left
- mild atrophy of the caudate, more pronounced on the left
- no evidence of atrophy or degeneration in the basal forebrain
- between moderate and severe bilateral hippocampus atrophy
- between moderate and severe bilateral accumbens atrophy
- severe bilateral amygdala atrophy, more pronounced on the left | SV |
NIFD_1_S_0099_MR_T1_mprage_S3_DIS3D_br_raw_20120819131043923_110_S161401_I324640_dupl_9 | On a T1-weighted brain MRI of a 69-year-old female subject, we observed:
For the subcortical structures:
- between mild and moderate bilateral accumbens atrophy
- severe bilateral putamen atrophy, more pronounced on the left
- between mild and moderate bilateral pallidum atrophy, more pronounced on the left
- basal forebrain appears structurally intact with no atrophic changes
- severe bilateral caudate atrophy
- mild left atrophy of the amygdala
- between normal and mild atrophy of the thalamus, more pronounced on the left
- between normal and mild bilateral ventral dc atrophy
- between normal and mild left atrophy of the hippocampus
For the cerebral cortex:
- no degenerative or atrophic changes noted in the insular cortex
- parietal lobe appears structurally intact with no atrophic changes
- focal atrophy of frontal lobe on triangular inf. frontal gyrus (moderate)
- focal atrophy of occipital lobe on middle occipital gyrus (between normal and mild)
- no signs of atrophy detected in the limbic cortex
- focal atrophy of temporal lobe on sup. temporal gyrus (between mild and moderate)
For the ventricles:
- no pathological changes consistent with enlargement noted in the 3rd ventricle
- no pathological changes consistent with enlargement noted in the inf. lateral ventricle
- between normal and mild left enlargement of the lateral ventricle
- no observable enlargement or abnormal growth in the 4th ventricle
- moderate enlargement of the external csf | PNFA |
NIFD_1_S_0061_MR_t1_mprage_S3_DIS3D_br_raw_20111215102518636_37_S133273_I272123_dupl_7 | On a T1-weighted brain MRI of a 53-year-old female subject, we observed:
For the ventricles:
- lateral ventricle maintains its normal volume without signs of enlargement
- no observable enlargement or abnormal growth in the 3rd ventricle
- between normal and mild enlargement of the external csf
- severe enlargement of the inf. lateral ventricle, more pronounced on the left
- no observable enlargement or abnormal growth in the 4th ventricle
For the cerebral cortex:
- focal atrophy of parietal lobe on supramarginal gyrus (moderate)
- moderate atrophy of the limbic cortex, with focal volume loss observed in the following subregions: anterior cingulate gyrus (between normal and mild) and parahippocampal gyrus (moderate)
- focal atrophy of frontal lobe on opercular inf. frontal gyrus (moderate)
- moderate atrophy of the temporal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (mild), planum temporale (moderate), inf. temporal gyrus (severe) and temporal pole (between normal and mild)
- between moderate and severe atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (between moderate and severe), posterior insula (between mild and moderate) and frontal operculum (mild)
- occipital lobe maintains its normal morphology without atrophic features
For the subcortical structures:
- pallidum appears structurally intact with no atrophic changes
- thalamus presents with a healthy appearance, free from atrophy
- between normal and mild atrophy of the caudate, more pronounced on the left
- no evidence of atrophy or degeneration in the accumbens
- ventral dc maintains its normal morphology without atrophic features
- moderate left atrophy of the putamen
- no evidence of atrophy or degeneration in the basal forebrain
- severe bilateral amygdala atrophy, more pronounced on the left
- between normal and mild atrophy of the hippocampus, more pronounced on the left | SV |
ADNI_007_S_4911_MR_Accelerated_SAG_IR-SPGR__br_raw_20120830145649374_62_S164218_I328209 | On a T1-weighted brain MRI of a 75-year-old male subject, we observed:
For the cerebral cortex:
- focal atrophy of insular cortex on parietal operculum (moderate)
- atrophies of limbic cortex on entorhinal area (between normal and mild) and posterior cingulate gyrus (moderate)
- atrophies of parietal lobe on angular gyrus (moderate) and precuneus (between moderate and severe)
- atrophies of frontal lobe on lateral orbital gyrus (mild) and sup. frontal gyrus medial segment (moderate)
- severe bilateral temporal lobe atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: inf. temporal gyrus (mild), middle temporal gyrus (severe) and temporal pole (mild)
- atrophies of occipital lobe on middle occipital gyrus (between normal and mild), sup. occipital gyrus (between normal and mild) and occipital pole (mild)
For the subcortical structures:
- moderate atrophy of the amygdala, more pronounced on the right
- no degenerative or atrophic changes noted in the putamen
- mild right atrophy of the caudate
- no evidence of atrophy or degeneration in the basal forebrain
- no evidence of atrophy or degeneration in the thalamus
- ventral dc appears structurally intact with no atrophic changes
- no observable atrophic alterations in the accumbens
- no observable atrophic alterations in the hippocampus
- no signs of atrophy detected in the pallidum
For the ventricles:
- no pathological changes consistent with enlargement noted in the 4th ventricle
- moderate enlargement of the 3rd ventricle
- severe bilateral lateral ventricle enlargement
- severe bilateral inf. lateral ventricle enlargement
- external csf appears structurally intact, with no evidence of enlargement | AD |
ADNI_024_S_4158_MR_MPRAGE_br_raw_20110815114120024_16_S118583_I250350 | On a T1-weighted brain MRI of a 85-year-old male subject, we observed:
For the subcortical structures:
- no degenerative or atrophic changes noted in the caudate
- pallidum presents with a healthy appearance, free from atrophy
- no signs of atrophy detected in the hippocampus
- no pathological changes consistent with atrophy detected in the basal forebrain
- no evidence of atrophy or degeneration in the thalamus
- no pathological changes consistent with atrophy detected in the ventral dc
- no degenerative or atrophic changes noted in the accumbens
- no evidence of atrophy or degeneration in the amygdala
- no observable atrophic alterations in the putamen
For the cerebral cortex:
- focal atrophy of limbic cortex on parahippocampal gyrus (moderate)
- focal atrophy of insular cortex on parietal operculum (between normal and mild)
- focal atrophy of parietal lobe on supramarginal gyrus (between normal and mild)
- no signs of atrophy detected in the occipital lobe
- focal atrophy of temporal lobe on planum temporale (between normal and mild)
- atrophies of frontal lobe on orbital inf. frontal gyrus (mild) and sup. frontal gyrus medial segment (mild)
For the ventricles:
- inf. lateral ventricle appears structurally intact, with no evidence of enlargement
- no abnormal enlargement observed in the lateral ventricle
- 3rd ventricle remains within normal size parameters, with no enlargement detected
- between normal and mild enlargement of the 4th ventricle
- the external csf shows no structural abnormalities indicative of enlargement | CN |
NIFD_1_S_0127_MR_T1_mprage_S3_DIS3D_br_raw_20170817113930950_131_S597781_I891241_dupl_3 | On a T1-weighted brain MRI of a 61-year-old male subject, we observed:
For the cerebral cortex:
- atrophies of frontal lobe on gyrus rectus (between mild and moderate), orbital inf. frontal gyrus (mild) and triangular inf. frontal gyrus (between normal and mild)
- no pathological changes consistent with atrophy detected in the parietal lobe
- severe bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: entorhinal area (severe), anterior cingulate gyrus (moderate) and parahippocampal gyrus (severe)
- atrophies of occipital lobe on calcarine cortex (mild), occipital fusiform gyrus (moderate) and inf. occipital gyrus (between normal and mild)
- between mild and moderate atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (between moderate and severe) and posterior insula (severe)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (severe), inf. temporal gyrus (mild), middle temporal gyrus (between mild and moderate), sup. temporal gyrus (mild) and temporal pole (severe)
For the subcortical structures:
- ventral dc presents with a healthy appearance, free from atrophy
- between mild and moderate left atrophy of the thalamus
- pallidum presents with a healthy appearance, free from atrophy
- severe bilateral hippocampus atrophy, more pronounced on the left
- between mild and moderate atrophy of the putamen, more pronounced on the left
- basal forebrain remains normal, with no signs of tissue loss
- severe bilateral amygdala atrophy, more pronounced on the left
- mild bilateral accumbens atrophy
- no signs of atrophy detected in the caudate
For the ventricles:
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
- moderate enlargement of the external csf
- 4th ventricle maintains its normal volume without signs of enlargement
- no pathological changes consistent with enlargement noted in the lateral ventricle
- no signs of enlargement detected in the 3rd ventricle | SV |
NIFD_1_S_0056_MR_t1_mprage_S3_DIS3D_br_raw_20111019194910586_85_S125860_I261681_dupl_1 | On a T1-weighted brain MRI of a 59-year-old male subject, we observed:
For the ventricles:
- moderate bilateral inf. lateral ventricle enlargement
- 4th ventricle is free from enlargement or excessive growth
- severe bilateral lateral ventricle enlargement
- no observable enlargement or abnormal growth in the external csf
- no pathological changes consistent with enlargement noted in the 3rd ventricle
For the subcortical structures:
- between normal and mild atrophy of the ventral dc, more pronounced on the left
- moderate bilateral caudate atrophy, more pronounced on the left
- severe bilateral thalamus atrophy, more pronounced on the left
- between mild and moderate atrophy of the hippocampus
- moderate bilateral amygdala atrophy
- no observable atrophic alterations in the basal forebrain
- putamen presents with a healthy appearance, free from atrophy
- between mild and moderate bilateral pallidum atrophy
- moderate bilateral accumbens atrophy
For the cerebral cortex:
- focal atrophy of limbic cortex on anterior cingulate gyrus (between normal and mild)
- occipital lobe appears structurally intact with no atrophic changes
- focal atrophy of temporal lobe on planum polare (mild)
- moderate atrophy of the parietal lobe, with focal volume loss observed in the following subregions: precuneus (between mild and moderate) and supramarginal gyrus (mild)
- atrophies of insular cortex on central operculum (between normal and mild) and parietal operculum (between moderate and severe)
- mild bilateral frontal lobe atrophy, with focal volume loss observed in the following subregions: gyrus rectus (mild), posterior orbital gyrus (between mild and moderate) and sup. frontal gyrus (between moderate and severe) | BV |
ADNI_033_S_4179_MR_MPRAGE_br_raw_20110824115448295_113_S119874_I252069 | On a T1-weighted brain MRI of a 83-year-old male subject, we observed:
For the cerebral cortex:
- parietal lobe presents with a healthy appearance, free from atrophy
- no evidence of atrophy or degeneration in the limbic cortex
- focal atrophy of frontal lobe on sup. frontal gyrus (between normal and mild)
- focal atrophy of temporal lobe on sup. temporal gyrus (between normal and mild)
- occipital lobe maintains its normal morphology without atrophic features
- insular cortex remains normal, with no signs of tissue loss
For the ventricles:
- 4th ventricle maintains its normal volume without signs of enlargement
- no pathological changes consistent with enlargement noted in the inf. lateral ventricle
- no enlargement observed in the 3rd ventricle
- the lateral ventricle shows no structural abnormalities indicative of enlargement
- external csf maintains its normal volume without signs of enlargement
For the subcortical structures:
- caudate remains normal, with no signs of tissue loss
- no observable atrophic alterations in the pallidum
- the thalamus shows no structural abnormalities indicative of atrophy
- no degenerative or atrophic changes noted in the basal forebrain
- no observable atrophic alterations in the hippocampus
- no signs of atrophy detected in the accumbens
- no observable atrophic alterations in the ventral dc
- amygdala presents with a healthy appearance, free from atrophy
- no degenerative or atrophic changes noted in the putamen | CN |
NIFD_1_S_0288_MR_t1_mprage__br_raw_20170814180736340_14_S594408_I886878 | On a T1-weighted brain MRI of a 64-year-old male subject, we observed:
For the ventricles:
- lateral ventricle is free from enlargement or excessive growth
- the external csf shows no structural abnormalities indicative of enlargement
- 4th ventricle remains within normal size parameters, with no enlargement detected
- the inf. lateral ventricle shows no structural abnormalities indicative of enlargement
- no pathological changes consistent with enlargement noted in the 3rd ventricle
For the subcortical structures:
- no evidence of atrophy or degeneration in the putamen
- between mild and moderate bilateral caudate atrophy
- pallidum presents with a healthy appearance, free from atrophy
- no signs of atrophy detected in the basal forebrain
- no pathological changes consistent with atrophy detected in the thalamus
- amygdala remains normal, with no signs of tissue loss
- mild bilateral ventral dc atrophy
- mild left atrophy of the hippocampus
- accumbens appears structurally intact with no atrophic changes
For the cerebral cortex:
- parietal lobe remains normal, with no signs of tissue loss
- no evidence of atrophy or degeneration in the occipital lobe
- no pathological changes consistent with atrophy detected in the insular cortex
- frontal lobe remains normal, with no signs of tissue loss
- focal atrophy of limbic cortex on parahippocampal gyrus (between mild and moderate)
- focal atrophy of temporal lobe on planum temporale (between mild and moderate) | CN |
NIFD_1_S_0010_MR_T1_MPRAGE_long_S4_DIS3D__br_raw_20110204151510599_49_S99062_I216003_dupl_3 | On a T1-weighted brain MRI of a 81-year-old male subject, we observed:
For the ventricles:
- no abnormal enlargement observed in the inf. lateral ventricle
- no abnormal enlargement observed in the 3rd ventricle
- no abnormal enlargement observed in the 4th ventricle
- mild enlargement of the external csf
- no enlargement observed in the lateral ventricle
For the cerebral cortex:
- atrophies of insular cortex on anterior insula (between normal and mild) and central operculum (between mild and moderate)
- between mild and moderate atrophy of the parietal lobe, with focal volume loss observed in the following subregions: angular gyrus (between mild and moderate) and postcentral gyrus (between normal and mild)
- temporal lobe appears structurally intact with no atrophic changes
- limbic cortex maintains its normal morphology without atrophic features
- occipital lobe remains normal, with no signs of tissue loss
- mild atrophy of the frontal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: gyrus rectus (between moderate and severe), precentral gyrus (severe), precentral gyrus medial segment (moderate), supplementary motor cortex (mild) and opercular inf. frontal gyrus (mild)
For the subcortical structures:
- between normal and mild atrophy of the ventral dc, more pronounced on the left
- no signs of atrophy detected in the amygdala
- the basal forebrain shows no structural abnormalities indicative of atrophy
- no signs of atrophy detected in the hippocampus
- between moderate and severe bilateral putamen atrophy, more pronounced on the left
- between normal and mild left atrophy of the accumbens
- mild atrophy of the pallidum, more pronounced on the left
- mild atrophy of the thalamus, more pronounced on the left
- between mild and moderate left atrophy of the caudate | PNFA |
NIFD_1_S_0091_MR_T1_mprage_S3_DIS3D_br_raw_20170817104021048_43_S597455_I890811_dupl_2 | On a T1-weighted brain MRI of a 57-year-old male subject, we observed:
For the cerebral cortex:
- atrophies of limbic cortex on entorhinal area (between normal and mild) and posterior cingulate gyrus (moderate)
- severe bilateral insular cortex atrophy, with focal volume loss observed in the following subregions: posterior insula (severe), central operculum (between normal and mild) and parietal operculum (moderate)
- atrophies of frontal lobe on anterior orbital gyrus (moderate) and posterior orbital gyrus (between normal and mild)
- occipital lobe maintains its normal morphology without atrophic features
- atrophies of temporal lobe on planum temporale (mild) and transverse temporal gyrus (mild)
- focal atrophy of parietal lobe on postcentral gyrus (between normal and mild)
For the subcortical structures:
- no degenerative or atrophic changes noted in the basal forebrain
- severe bilateral thalamus atrophy
- no pathological changes consistent with atrophy detected in the pallidum
- the caudate shows no structural abnormalities indicative of atrophy
- putamen presents with a healthy appearance, free from atrophy
- no observable atrophic alterations in the accumbens
- hippocampus appears structurally intact with no atrophic changes
- no pathological changes consistent with atrophy detected in the amygdala
- no evidence of atrophy or degeneration in the ventral dc
For the ventricles:
- mild right enlargement of the lateral ventricle
- no pathological changes consistent with enlargement noted in the inf. lateral ventricle
- external csf maintains its normal volume without signs of enlargement
- between normal and mild enlargement of the 3rd ventricle
- 4th ventricle appears structurally intact, with no evidence of enlargement | BV |
NIFD_1_S_0050_MR_T1_MPRAGE_long_S2_DIS3D__br_raw_20110718081422479_31_S115040_I245234_dupl_13 | On a T1-weighted brain MRI of a 75-year-old female subject, we observed:
For the ventricles:
- no signs of enlargement detected in the lateral ventricle
- severe enlargement of the external csf
- no pathological changes consistent with enlargement noted in the 4th ventricle
- no observable enlargement or abnormal growth in the 3rd ventricle
- inf. lateral ventricle appears structurally intact, with no evidence of enlargement
For the subcortical structures:
- severe bilateral putamen atrophy, more pronounced on the right
- moderate bilateral accumbens atrophy
- no observable atrophic alterations in the hippocampus
- between moderate and severe bilateral caudate atrophy, more pronounced on the right
- between moderate and severe bilateral ventral dc atrophy, more pronounced on the right
- no pathological changes consistent with atrophy detected in the basal forebrain
- severe bilateral amygdala atrophy, more pronounced on the right
- no degenerative or atrophic changes noted in the thalamus
- between moderate and severe bilateral pallidum atrophy, more pronounced on the right
For the cerebral cortex:
- between moderate and severe bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: entorhinal area (mild), anterior cingulate gyrus (mild), middle cingulate gyrus (mild) and parahippocampal gyrus (moderate)
- focal atrophy of parietal lobe on supramarginal gyrus (between normal and mild)
- severe bilateral frontal lobe atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: middle frontal gyrus (mild), anterior orbital gyrus (mild), precentral gyrus (severe), sup. frontal gyrus (mild), supplementary motor cortex (severe) and precentral gyrus medial segment (mild)
- severe bilateral insular cortex atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (moderate) and central operculum (moderate)
- between mild and moderate atrophy of the temporal lobe, more pronounced on the right, with focal volume loss observed in the following subregions: fusiform gyrus (between moderate and severe) and temporal pole (mild)
- no signs of atrophy detected in the occipital lobe | PNFA |
NIFD_1_S_0067_MR_t1_mprage_S6_DIS3D_br_raw_20111209120245536_154_S132398_I270856_dupl_6 | On a T1-weighted brain MRI of a 78-year-old male subject, we observed:
For the cerebral cortex:
- focal atrophy of limbic cortex on anterior cingulate gyrus (between normal and mild)
- focal atrophy of temporal lobe on middle temporal gyrus (between mild and moderate)
- between normal and mild atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: posterior insula (between normal and mild)
- atrophies of frontal lobe on orbital inf. frontal gyrus (mild), middle frontal gyrus (between normal and mild), medial orbital gyrus (between normal and mild), posterior orbital gyrus (moderate) and sup. frontal gyrus medial segment (between normal and mild)
- focal atrophy of occipital lobe on calcarine cortex (between normal and mild)
- the parietal lobe shows no structural abnormalities indicative of atrophy
For the subcortical structures:
- between moderate and severe bilateral accumbens atrophy
- moderate left atrophy of the thalamus
- between normal and mild left atrophy of the ventral dc
- moderate bilateral caudate atrophy, more pronounced on the left
- basal forebrain presents with a healthy appearance, free from atrophy
- severe bilateral amygdala atrophy, more pronounced on the left
- between mild and moderate atrophy of the putamen, more pronounced on the left
- between normal and mild atrophy of the hippocampus, more pronounced on the left
- between mild and moderate atrophy of the pallidum, more pronounced on the left
For the ventricles:
- mild enlargement of the lateral ventricle
- moderate enlargement of the 3rd ventricle
- mild enlargement of the external csf
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
- 4th ventricle appears structurally intact, with no evidence of enlargement | PNFA |
ADNI_127_S_4198_MR_Accelerated_Sag_IR-SPGR__br_raw_20110902083648052_131_S121087_I254317 | On a T1-weighted brain MRI of a 78-year-old female subject, we observed:
For the subcortical structures:
- putamen appears structurally intact with no atrophic changes
- pallidum maintains its normal morphology without atrophic features
- no observable atrophic alterations in the basal forebrain
- no degenerative or atrophic changes noted in the amygdala
- no pathological changes consistent with atrophy detected in the ventral dc
- the accumbens shows no structural abnormalities indicative of atrophy
- caudate remains normal, with no signs of tissue loss
- the hippocampus shows no structural abnormalities indicative of atrophy
- no pathological changes consistent with atrophy detected in the thalamus
For the ventricles:
- lateral ventricle appears structurally intact, with no evidence of enlargement
- no signs of enlargement detected in the 4th ventricle
- inf. lateral ventricle remains within normal size parameters, with no enlargement detected
- no signs of enlargement detected in the 3rd ventricle
- no abnormal enlargement observed in the external csf
For the cerebral cortex:
- focal atrophy of parietal lobe on postcentral gyrus (mild)
- the temporal lobe shows no structural abnormalities indicative of atrophy
- limbic cortex appears structurally intact with no atrophic changes
- atrophies of occipital lobe on calcarine cortex (mild), cuneus (between normal and mild) and occipital pole (between normal and mild)
- focal atrophy of frontal lobe on medial frontal cortex (mild)
- insular cortex presents with a healthy appearance, free from atrophy | CN |
ADNI_067_S_5205_MR_MPRAGE_br_raw_20130617123032185_46_S192528_I376818_dupl_1 | On a T1-weighted brain MRI of a 60-year-old female subject, we observed:
For the ventricles:
- lateral ventricle is free from enlargement or excessive growth
- no signs of enlargement detected in the 3rd ventricle
- between moderate and severe enlargement of the inf. lateral ventricle, more pronounced on the right
- the 4th ventricle shows no structural abnormalities indicative of enlargement
- moderate enlargement of the external csf
For the cerebral cortex:
- between moderate and severe bilateral parietal lobe atrophy, with focal volume loss observed in the following subregions: angular gyrus (between mild and moderate), precuneus (mild) and supramarginal gyrus (between moderate and severe)
- severe bilateral frontal lobe atrophy, with focal volume loss observed in the following subregions: opercular inf. frontal gyrus (between normal and mild), medial frontal cortex (mild), middle frontal gyrus (severe), anterior orbital gyrus (between moderate and severe) and sup. frontal gyrus (between moderate and severe)
- no pathological changes consistent with atrophy detected in the limbic cortex
- between mild and moderate atrophy of the temporal lobe, more pronounced on the right, with focal volume loss observed in the following subregions: fusiform gyrus (between normal and mild)
- occipital lobe remains normal, with no signs of tissue loss
- between normal and mild atrophy of the insular cortex, with focal volume loss observed in the following subregions: frontal operculum (mild)
For the subcortical structures:
- no observable atrophic alterations in the caudate
- thalamus remains normal, with no signs of tissue loss
- no degenerative or atrophic changes noted in the ventral dc
- accumbens remains normal, with no signs of tissue loss
- basal forebrain appears structurally intact with no atrophic changes
- between moderate and severe bilateral amygdala atrophy
- the hippocampus shows no structural abnormalities indicative of atrophy
- no signs of atrophy detected in the putamen
- no pathological changes consistent with atrophy detected in the pallidum | AD |
ADNI_123_S_4526_MR_MPRAGE_br_raw_20120209093528861_37_S140267_I283603 | On a T1-weighted brain MRI of a 80-year-old male subject, we observed:
For the ventricles:
- no abnormal enlargement observed in the lateral ventricle
- the 3rd ventricle shows no structural abnormalities indicative of enlargement
- between normal and mild left enlargement of the inf. lateral ventricle
- no signs of enlargement detected in the external csf
- 4th ventricle maintains its normal volume without signs of enlargement
For the cerebral cortex:
- no signs of atrophy detected in the frontal lobe
- no degenerative or atrophic changes noted in the insular cortex
- focal atrophy of temporal lobe on sup. temporal gyrus (between normal and mild)
- no signs of atrophy detected in the parietal lobe
- the occipital lobe shows no structural abnormalities indicative of atrophy
- limbic cortex maintains its normal morphology without atrophic features
For the subcortical structures:
- pallidum maintains its normal morphology without atrophic features
- the accumbens shows no structural abnormalities indicative of atrophy
- severe bilateral amygdala atrophy, more pronounced on the left
- no evidence of atrophy or degeneration in the basal forebrain
- no degenerative or atrophic changes noted in the putamen
- no signs of atrophy detected in the ventral dc
- no degenerative or atrophic changes noted in the caudate
- moderate atrophy of the hippocampus, more pronounced on the left
- thalamus maintains its normal morphology without atrophic features | AD |
NIFD_2_S_0002_MR_MT1__GradWarp__N3m_Br_20111229184614074_S133938_I274719 | On a T1-weighted brain MRI of a 64-year-old male subject, we observed:
For the ventricles:
- no pathological changes consistent with enlargement noted in the 4th ventricle
- severe enlargement of the 3rd ventricle
- between moderate and severe enlargement of the lateral ventricle, more pronounced on the right
- moderate enlargement of the external csf
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the right
For the cerebral cortex:
- moderate atrophy of the limbic cortex, more pronounced on the right, with focal volume loss observed in the following subregions: anterior cingulate gyrus (severe)
- focal atrophy of parietal lobe on angular gyrus (between normal and mild)
- severe atrophy of the insular cortex, more pronounced on the right, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (between normal and mild) and frontal operculum (between moderate and severe)
- severe bilateral frontal lobe atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: frontal pole (severe), gyrus rectus (severe), opercular inf. frontal gyrus (moderate), medial frontal cortex (between mild and moderate), middle frontal gyrus (severe), anterior orbital gyrus (severe), lateral orbital gyrus (severe), medial orbital gyrus (between moderate and severe), posterior orbital gyrus (moderate), sup. frontal gyrus (between moderate and severe), sup. frontal gyrus medial segment (severe) and triangular inf. frontal gyrus (between normal and mild)
- atrophies of temporal lobe on temporal pole (between normal and mild) and middle temporal gyrus (between normal and mild)
- no evidence of atrophy or degeneration in the occipital lobe
For the subcortical structures:
- moderate atrophy of the thalamus, more pronounced on the right
- no pathological changes consistent with atrophy detected in the amygdala
- severe bilateral caudate atrophy, more pronounced on the right
- severe bilateral accumbens atrophy, more pronounced on the right
- between normal and mild atrophy of the ventral dc, more pronounced on the right
- severe bilateral pallidum atrophy, more pronounced on the right
- between mild and moderate atrophy of the hippocampus, more pronounced on the right
- no pathological changes consistent with atrophy detected in the basal forebrain
- severe bilateral putamen atrophy, more pronounced on the right | BV |
NIFD_1_S_0347_MR_T1_mprage_S17_DIS3D__br_raw_20170629034809877_28_S578320_I868238_dupl_8 | On a T1-weighted brain MRI of a 61-year-old female subject, we observed:
For the subcortical structures:
- between moderate and severe bilateral accumbens atrophy
- mild atrophy of the caudate, more pronounced on the left
- no evidence of atrophy or degeneration in the ventral dc
- severe bilateral putamen atrophy, more pronounced on the left
- mild left atrophy of the pallidum
- between moderate and severe bilateral hippocampus atrophy
- moderate bilateral thalamus atrophy, more pronounced on the left
- no degenerative or atrophic changes noted in the basal forebrain
- severe bilateral amygdala atrophy, more pronounced on the left
For the cerebral cortex:
- between moderate and severe bilateral occipital lobe atrophy, with focal volume loss observed in the following subregions: calcarine cortex (moderate), cuneus (between moderate and severe), occipital fusiform gyrus (between normal and mild) and lingual gyrus (between normal and mild)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (severe), planum polare (moderate), inf. temporal gyrus (severe), middle temporal gyrus (between moderate and severe) and temporal pole (severe)
- moderate atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (mild) and frontal operculum (between normal and mild)
- mild atrophy of the frontal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: middle frontal gyrus (between mild and moderate), anterior orbital gyrus (mild) and sup. frontal gyrus medial segment (between normal and mild)
- focal atrophy of parietal lobe on precuneus (between normal and mild)
- severe bilateral limbic cortex atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: entorhinal area (between moderate and severe), anterior cingulate gyrus (severe) and parahippocampal gyrus (between normal and mild)
For the ventricles:
- between moderate and severe bilateral lateral ventricle enlargement
- no pathological changes consistent with enlargement noted in the 4th ventricle
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
- severe enlargement of the external csf
- 3rd ventricle is free from enlargement or excessive growth | SV |
NIFD_1_S_0347_MR_T1_mprage_S17_DIS3D__br_raw_20170629034809877_28_S578320_I868238_dupl_4 | On a T1-weighted brain MRI of a 61-year-old female subject, we observed:
For the ventricles:
- no pathological changes consistent with enlargement noted in the 4th ventricle
- between moderate and severe bilateral lateral ventricle enlargement
- severe enlargement of the external csf
- 3rd ventricle appears structurally intact, with no evidence of enlargement
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
For the subcortical structures:
- mild left atrophy of the pallidum
- between moderate and severe bilateral accumbens atrophy
- moderate bilateral thalamus atrophy, more pronounced on the left
- between moderate and severe bilateral hippocampus atrophy
- ventral dc remains normal, with no signs of tissue loss
- mild atrophy of the caudate, more pronounced on the left
- no pathological changes consistent with atrophy detected in the basal forebrain
- severe bilateral amygdala atrophy, more pronounced on the left
- severe bilateral putamen atrophy, more pronounced on the left
For the cerebral cortex:
- mild atrophy of the frontal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: middle frontal gyrus (between mild and moderate), anterior orbital gyrus (mild) and sup. frontal gyrus medial segment (between normal and mild)
- between moderate and severe bilateral occipital lobe atrophy, with focal volume loss observed in the following subregions: calcarine cortex (moderate), cuneus (between moderate and severe), occipital fusiform gyrus (between normal and mild) and lingual gyrus (between normal and mild)
- moderate atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (mild) and frontal operculum (between normal and mild)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (severe), planum polare (moderate), inf. temporal gyrus (severe), middle temporal gyrus (between moderate and severe) and temporal pole (severe)
- focal atrophy of parietal lobe on precuneus (between normal and mild)
- severe bilateral limbic cortex atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: entorhinal area (between moderate and severe), anterior cingulate gyrus (severe) and parahippocampal gyrus (between normal and mild) | SV |
NIFD_1_S_0040_MR_t1_mprage_S3_DIS3D_br_raw_20150522131343256_7_S261234_I494492_dupl_3 | On a T1-weighted brain MRI of a 71-year-old female subject, we observed:
For the subcortical structures:
- severe bilateral pallidum atrophy, more pronounced on the left
- between moderate and severe bilateral amygdala atrophy
- mild atrophy of the hippocampus, more pronounced on the left
- severe bilateral caudate atrophy, more pronounced on the left
- severe bilateral accumbens atrophy, more pronounced on the left
- basal forebrain remains normal, with no signs of tissue loss
- moderate bilateral ventral dc atrophy
- severe bilateral thalamus atrophy, more pronounced on the left
- severe bilateral putamen atrophy, more pronounced on the left
For the ventricles:
- moderate enlargement of the 3rd ventricle
- the 4th ventricle shows no structural abnormalities indicative of enlargement
- severe enlargement of the external csf
- severe bilateral lateral ventricle enlargement
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
For the cerebral cortex:
- severe bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: anterior cingulate gyrus (severe), middle cingulate gyrus (moderate), posterior cingulate gyrus (between normal and mild) and parahippocampal gyrus (between normal and mild)
- no evidence of atrophy or degeneration in the occipital lobe
- atrophies of temporal lobe on planum polare (between normal and mild) and sup. temporal gyrus (between normal and mild)
- severe bilateral insular cortex atrophy, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (mild), frontal operculum (moderate) and parietal operculum (moderate)
- severe bilateral frontal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: frontal pole (severe), gyrus rectus (severe), opercular inf. frontal gyrus (between moderate and severe), triangular inf. frontal gyrus (severe), medial frontal cortex (moderate), middle frontal gyrus (severe), lateral orbital gyrus (between mild and moderate), medial orbital gyrus (moderate), posterior orbital gyrus (moderate), sup. frontal gyrus (between moderate and severe), sup. frontal gyrus medial segment (moderate) and precentral gyrus (mild)
- focal atrophy of parietal lobe on precuneus (between normal and mild) | BV |
NIFD_3_S_0002_MR_T1_mprage__br_raw_20160518171333316_118_S442724_I709714_dupl_6 | On a T1-weighted brain MRI of a 64-year-old male subject, we observed:
For the subcortical structures:
- thalamus maintains its normal morphology without atrophic features
- severe bilateral amygdala atrophy, more pronounced on the left
- moderate atrophy of the hippocampus, more pronounced on the left
- no degenerative or atrophic changes noted in the basal forebrain
- moderate bilateral caudate atrophy, more pronounced on the left
- between moderate and severe bilateral putamen atrophy, more pronounced on the left
- moderate bilateral pallidum atrophy, more pronounced on the left
- between normal and mild atrophy of the accumbens, more pronounced on the left
- mild atrophy of the ventral dc, more pronounced on the left
For the ventricles:
- the 4th ventricle shows no structural abnormalities indicative of enlargement
- moderate enlargement of the external csf
- the 3rd ventricle shows no structural abnormalities indicative of enlargement
- no observable enlargement or abnormal growth in the lateral ventricle
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
For the cerebral cortex:
- focal atrophy of frontal lobe on anterior orbital gyrus (between mild and moderate)
- between mild and moderate atrophy of the limbic cortex, more pronounced on the left, with focal volume loss observed in the following subregions: entorhinal area (severe) and parahippocampal gyrus (between moderate and severe)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (severe), inf. temporal gyrus (severe), middle temporal gyrus (between moderate and severe), sup. temporal gyrus (mild) and temporal pole (severe)
- focal atrophy of occipital lobe on occipital fusiform gyrus (between moderate and severe)
- focal atrophy of parietal lobe on angular gyrus (between moderate and severe)
- between moderate and severe atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe) and posterior insula (between moderate and severe) | SV |
NIFD_1_S_0127_MR_T1_mprage_S3_DIS3D_br_raw_20170817113930950_131_S597781_I891241_dupl_6 | On a T1-weighted brain MRI of a 61-year-old male subject, we observed:
For the cerebral cortex:
- no signs of atrophy detected in the parietal lobe
- between mild and moderate atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (between moderate and severe) and posterior insula (severe)
- atrophies of frontal lobe on gyrus rectus (between mild and moderate), orbital inf. frontal gyrus (mild) and triangular inf. frontal gyrus (between normal and mild)
- severe bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: entorhinal area (severe), anterior cingulate gyrus (moderate) and parahippocampal gyrus (severe)
- atrophies of occipital lobe on calcarine cortex (mild), occipital fusiform gyrus (moderate) and inf. occipital gyrus (between normal and mild)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (severe), inf. temporal gyrus (mild), middle temporal gyrus (between mild and moderate), sup. temporal gyrus (mild) and temporal pole (severe)
For the ventricles:
- moderate enlargement of the external csf
- no signs of enlargement detected in the 4th ventricle
- no abnormal enlargement observed in the lateral ventricle
- no enlargement observed in the 3rd ventricle
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
For the subcortical structures:
- no pathological changes consistent with atrophy detected in the basal forebrain
- severe bilateral hippocampus atrophy, more pronounced on the left
- the pallidum shows no structural abnormalities indicative of atrophy
- severe bilateral amygdala atrophy, more pronounced on the left
- no evidence of atrophy or degeneration in the caudate
- the ventral dc shows no structural abnormalities indicative of atrophy
- mild bilateral accumbens atrophy
- between mild and moderate left atrophy of the thalamus
- between mild and moderate atrophy of the putamen, more pronounced on the left | SV |
NIFD_2_S_0013_MR_MT1__GradWarp__N3m_Br_20111229190902340_S134506_I274738_dupl_2 | On a T1-weighted brain MRI of a 69-year-old male subject, we observed:
For the cerebral cortex:
- atrophies of parietal lobe on angular gyrus (between mild and moderate) and postcentral gyrus medial segment (mild)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (severe), planum polare (mild), inf. temporal gyrus (between moderate and severe), middle temporal gyrus (severe), sup. temporal gyrus (between normal and mild) and temporal pole (severe)
- atrophies of frontal lobe on gyrus rectus (mild), opercular inf. frontal gyrus (mild) and lateral orbital gyrus (between normal and mild)
- mild atrophy of the occipital lobe, with focal volume loss observed in the following subregions: cuneus (between normal and mild), occipital fusiform gyrus (mild) and middle occipital gyrus (severe)
- moderate atrophy of the limbic cortex, more pronounced on the left, with focal volume loss observed in the following subregions: entorhinal area (severe) and parahippocampal gyrus (between mild and moderate)
- between normal and mild atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: posterior insula (mild)
For the ventricles:
- no observable enlargement or abnormal growth in the lateral ventricle
- no abnormal enlargement observed in the 4th ventricle
- severe bilateral inf. lateral ventricle enlargement
- no observable enlargement or abnormal growth in the external csf
- 3rd ventricle maintains its normal volume without signs of enlargement
For the subcortical structures:
- basal forebrain appears structurally intact with no atrophic changes
- between moderate and severe atrophy of the hippocampus, more pronounced on the left
- no degenerative or atrophic changes noted in the pallidum
- no observable atrophic alterations in the caudate
- the thalamus shows no structural abnormalities indicative of atrophy
- severe bilateral amygdala atrophy, more pronounced on the left
- mild atrophy of the accumbens
- ventral dc remains normal, with no signs of tissue loss
- no pathological changes consistent with atrophy detected in the putamen | SV |
ADNI_024_S_4280_MR_MPRAGE_br_raw_20111018163207473_117_S125582_I261332_dupl_1 | On a T1-weighted brain MRI of a 80-year-old male subject, we observed:
For the subcortical structures:
- between normal and mild left atrophy of the thalamus
- severe bilateral hippocampus atrophy
- severe bilateral amygdala atrophy, more pronounced on the right
- no signs of atrophy detected in the caudate
- accumbens remains normal, with no signs of tissue loss
- ventral dc appears structurally intact with no atrophic changes
- no signs of atrophy detected in the putamen
- the pallidum shows no structural abnormalities indicative of atrophy
- no pathological changes consistent with atrophy detected in the basal forebrain
For the ventricles:
- no enlargement observed in the 3rd ventricle
- the inf. lateral ventricle shows no structural abnormalities indicative of enlargement
- no signs of enlargement detected in the lateral ventricle
- no abnormal enlargement observed in the 4th ventricle
- between moderate and severe enlargement of the external csf
For the cerebral cortex:
- no evidence of atrophy or degeneration in the occipital lobe
- parietal lobe remains normal, with no signs of tissue loss
- mild atrophy of the limbic cortex, more pronounced on the left, with focal volume loss observed in the following subregions: entorhinal area (between mild and moderate) and parahippocampal gyrus (between mild and moderate)
- atrophies of temporal lobe on transverse temporal gyrus (between normal and mild) and temporal pole (between normal and mild)
- atrophies of frontal lobe on frontal pole (mild) and posterior orbital gyrus (between moderate and severe)
- no evidence of atrophy or degeneration in the insular cortex | AD |
ADNI_082_S_4339_MR_MPRAGE_br_raw_20111110142444516_129_S128898_I265938 | On a T1-weighted brain MRI of a 85-year-old male subject, we observed:
For the cerebral cortex:
- limbic cortex remains normal, with no signs of tissue loss
- focal atrophy of insular cortex on parietal operculum (between normal and mild)
- atrophies of temporal lobe on planum temporale (moderate), sup. temporal gyrus (mild) and transverse temporal gyrus (between moderate and severe)
- occipital lobe remains normal, with no signs of tissue loss
- atrophies of frontal lobe on orbital inf. frontal gyrus (between mild and moderate), lateral orbital gyrus (between normal and mild) and sup. frontal gyrus (mild)
- no degenerative or atrophic changes noted in the parietal lobe
For the ventricles:
- 3rd ventricle maintains its normal volume without signs of enlargement
- no enlargement observed in the external csf
- no abnormal enlargement observed in the 4th ventricle
- no observable enlargement or abnormal growth in the lateral ventricle
- between normal and mild right enlargement of the inf. lateral ventricle
For the subcortical structures:
- amygdala appears structurally intact with no atrophic changes
- no evidence of atrophy or degeneration in the accumbens
- putamen maintains its normal morphology without atrophic features
- hippocampus presents with a healthy appearance, free from atrophy
- the thalamus shows no structural abnormalities indicative of atrophy
- pallidum presents with a healthy appearance, free from atrophy
- basal forebrain presents with a healthy appearance, free from atrophy
- caudate maintains its normal morphology without atrophic features
- ventral dc appears structurally intact with no atrophic changes | CN |
NIFD_1_S_0169_MR_T1_mprage_S3_DIS3D_br_raw_20140701110602779_92_S223672_I433733_dupl_1 | On a T1-weighted brain MRI of a 74-year-old female subject, we observed:
For the ventricles:
- the external csf shows no structural abnormalities indicative of enlargement
- 4th ventricle appears structurally intact, with no evidence of enlargement
- no signs of enlargement detected in the lateral ventricle
- no observable enlargement or abnormal growth in the 3rd ventricle
- between normal and mild right enlargement of the inf. lateral ventricle
For the cerebral cortex:
- mild atrophy of the frontal lobe, more pronounced on the right, with focal volume loss observed in the following subregions: sup. frontal gyrus (between moderate and severe)
- moderate bilateral insular cortex atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (between normal and mild) and central operculum (moderate)
- atrophies of occipital lobe on cuneus (between mild and moderate) and occipital pole (between normal and mild)
- atrophies of temporal lobe on planum temporale (moderate), sup. temporal gyrus (between mild and moderate) and transverse temporal gyrus (between normal and mild)
- focal atrophy of limbic cortex on parahippocampal gyrus (between normal and mild)
- no degenerative or atrophic changes noted in the parietal lobe
For the subcortical structures:
- no observable atrophic alterations in the ventral dc
- no observable atrophic alterations in the pallidum
- between moderate and severe bilateral hippocampus atrophy, more pronounced on the right
- caudate appears structurally intact with no atrophic changes
- no pathological changes consistent with atrophy detected in the amygdala
- no degenerative or atrophic changes noted in the putamen
- no pathological changes consistent with atrophy detected in the thalamus
- no pathological changes consistent with atrophy detected in the accumbens
- no evidence of atrophy or degeneration in the basal forebrain | PNFA |
ADNI_024_S_5054_MR_MPRAGE_br_raw_20121220180216980_73_S178405_I352573_dupl_2 | On a T1-weighted brain MRI of a 74-year-old female subject, we observed:
For the cerebral cortex:
- focal atrophy of temporal lobe on transverse temporal gyrus (mild)
- no degenerative or atrophic changes noted in the insular cortex
- between moderate and severe bilateral occipital lobe atrophy, with focal volume loss observed in the following subregions: occipital fusiform gyrus (moderate) and occipital pole (moderate)
- focal atrophy of frontal lobe on anterior orbital gyrus (between normal and mild)
- the limbic cortex shows no structural abnormalities indicative of atrophy
- focal atrophy of parietal lobe on precuneus (between normal and mild)
For the ventricles:
- no signs of enlargement detected in the 4th ventricle
- between normal and mild left enlargement of the lateral ventricle
- the external csf shows no structural abnormalities indicative of enlargement
- no enlargement observed in the 3rd ventricle
- severe bilateral inf. lateral ventricle enlargement
For the subcortical structures:
- caudate appears structurally intact with no atrophic changes
- accumbens presents with a healthy appearance, free from atrophy
- mild atrophy of the hippocampus
- basal forebrain appears structurally intact with no atrophic changes
- no evidence of atrophy or degeneration in the thalamus
- no signs of atrophy detected in the amygdala
- no pathological changes consistent with atrophy detected in the ventral dc
- the putamen shows no structural abnormalities indicative of atrophy
- pallidum maintains its normal morphology without atrophic features | AD |
NIFD_2_S_0004_MR_MT1__GradWarp__N3m_Br_20120105162046732_S133219_I275501 | On a T1-weighted brain MRI of a 66-year-old male subject, we observed:
For the ventricles:
- 4th ventricle remains within normal size parameters, with no enlargement detected
- between moderate and severe bilateral lateral ventricle enlargement
- severe bilateral inf. lateral ventricle enlargement
- between moderate and severe enlargement of the 3rd ventricle
- moderate enlargement of the external csf
For the cerebral cortex:
- no degenerative or atrophic changes noted in the parietal lobe
- no evidence of atrophy or degeneration in the occipital lobe
- severe bilateral insular cortex atrophy, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (severe) and frontal operculum (between mild and moderate)
- severe bilateral temporal lobe atrophy, with focal volume loss observed in the following subregions: fusiform gyrus (between moderate and severe), planum polare (moderate), inf. temporal gyrus (severe), middle temporal gyrus (mild) and temporal pole (severe)
- moderate bilateral frontal lobe atrophy, with focal volume loss observed in the following subregions: gyrus rectus (severe), medial frontal cortex (between moderate and severe), middle frontal gyrus (moderate), medial orbital gyrus (between moderate and severe) and subcallosal area (mild)
- severe bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: entorhinal area (severe), anterior cingulate gyrus (between moderate and severe), middle cingulate gyrus (moderate) and parahippocampal gyrus (severe)
For the subcortical structures:
- severe bilateral putamen atrophy
- severe bilateral accumbens atrophy
- between normal and mild left atrophy of the caudate
- no evidence of atrophy or degeneration in the ventral dc
- basal forebrain remains normal, with no signs of tissue loss
- severe bilateral hippocampus atrophy
- between normal and mild atrophy of the thalamus
- moderate bilateral pallidum atrophy
- severe bilateral amygdala atrophy, more pronounced on the left | BV |
NIFD_2_S_0030_MR_MT1__GradWarp__N3m_Br_20130111113347184_S179870_I354749_dupl_2 | On a T1-weighted brain MRI of a 65-year-old male subject, we observed:
For the ventricles:
- moderate enlargement of the inf. lateral ventricle, more pronounced on the left
- no abnormal enlargement observed in the 4th ventricle
- between normal and mild enlargement of the 3rd ventricle
- severe enlargement of the external csf
- no abnormal enlargement observed in the lateral ventricle
For the subcortical structures:
- basal forebrain appears structurally intact with no atrophic changes
- between mild and moderate left atrophy of the thalamus
- mild left atrophy of the pallidum
- no observable atrophic alterations in the ventral dc
- between moderate and severe atrophy of the amygdala, more pronounced on the left
- severe bilateral putamen atrophy, more pronounced on the left
- between normal and mild atrophy of the hippocampus, more pronounced on the left
- severe bilateral accumbens atrophy, more pronounced on the left
- severe bilateral caudate atrophy, more pronounced on the left
For the cerebral cortex:
- the occipital lobe shows no structural abnormalities indicative of atrophy
- between moderate and severe bilateral insular cortex atrophy, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (moderate) and frontal operculum (moderate)
- severe bilateral frontal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: frontal pole (between moderate and severe), gyrus rectus (mild), opercular inf. frontal gyrus (between mild and moderate), triangular inf. frontal gyrus (mild), medial frontal cortex (between mild and moderate), middle frontal gyrus (severe), lateral orbital gyrus (moderate), medial orbital gyrus (severe), sup. frontal gyrus (severe) and supplementary motor cortex (moderate)
- parietal lobe maintains its normal morphology without atrophic features
- between moderate and severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (between normal and mild), middle temporal gyrus (mild) and sup. temporal gyrus (between mild and moderate)
- focal atrophy of limbic cortex on anterior cingulate gyrus (severe) | BV |
NIFD_2_S_0029_MR_MT1__GradWarp__N3m_Br_20130103113440420_S178016_I353168_dupl_4 | On a T1-weighted brain MRI of a 66-year-old male subject, we observed:
For the subcortical structures:
- severe bilateral accumbens atrophy, more pronounced on the left
- thalamus maintains its normal morphology without atrophic features
- moderate atrophy of the putamen, more pronounced on the left
- severe bilateral caudate atrophy, more pronounced on the left
- no pathological changes consistent with atrophy detected in the basal forebrain
- severe bilateral amygdala atrophy, more pronounced on the left
- ventral dc maintains its normal morphology without atrophic features
- pallidum presents with a healthy appearance, free from atrophy
- mild left atrophy of the hippocampus
For the cerebral cortex:
- severe bilateral frontal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: frontal pole (between moderate and severe), gyrus rectus (severe), opercular inf. frontal gyrus (severe), orbital inf. frontal gyrus (severe), medial frontal cortex (severe), middle frontal gyrus (severe), anterior orbital gyrus (between moderate and severe), lateral orbital gyrus (severe), medial orbital gyrus (severe), posterior orbital gyrus (severe), precentral gyrus medial segment (moderate), subcallosal area (between moderate and severe), sup. frontal gyrus (between mild and moderate) and sup. frontal gyrus medial segment (severe)
- focal atrophy of occipital lobe on cuneus (mild)
- severe bilateral insular cortex atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (between normal and mild) and frontal operculum (moderate)
- between moderate and severe atrophy of the temporal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: middle temporal gyrus (moderate) and temporal pole (between moderate and severe)
- severe bilateral limbic cortex atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: entorhinal area (moderate) and anterior cingulate gyrus (severe)
- the parietal lobe shows no structural abnormalities indicative of atrophy
For the ventricles:
- severe bilateral lateral ventricle enlargement
- moderate enlargement of the 3rd ventricle
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
- severe enlargement of the external csf
- 4th ventricle remains within normal size parameters, with no enlargement detected | BV |
NIFD_2_S_0027_MR_MT1__GradWarp__N3m_Br_20130103113648528_S177998_I353170 | On a T1-weighted brain MRI of a 58-year-old female subject, we observed:
For the cerebral cortex:
- between moderate and severe bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: entorhinal area (severe) and parahippocampal gyrus (severe)
- no observable atrophic alterations in the parietal lobe
- focal atrophy of occipital lobe on cuneus (between normal and mild)
- moderate bilateral insular cortex atrophy, with focal volume loss observed in the following subregions: anterior insula (severe) and posterior insula (between normal and mild)
- atrophies of frontal lobe on lateral orbital gyrus (moderate) and opercular inf. frontal gyrus (between normal and mild)
- severe bilateral temporal lobe atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: fusiform gyrus (moderate), middle temporal gyrus (moderate), sup. temporal gyrus (between normal and mild) and temporal pole (severe)
For the subcortical structures:
- thalamus appears structurally intact with no atrophic changes
- basal forebrain appears structurally intact with no atrophic changes
- between mild and moderate atrophy of the accumbens, more pronounced on the right
- no observable atrophic alterations in the ventral dc
- severe bilateral amygdala atrophy
- between mild and moderate bilateral putamen atrophy
- caudate presents with a healthy appearance, free from atrophy
- between mild and moderate bilateral pallidum atrophy
- severe bilateral hippocampus atrophy, more pronounced on the left
For the ventricles:
- mild enlargement of the 4th ventricle
- no pathological changes consistent with enlargement noted in the lateral ventricle
- the 3rd ventricle shows no structural abnormalities indicative of enlargement
- severe enlargement of the external csf
- between normal and mild enlargement of the inf. lateral ventricle, more pronounced on the left | BV |
ADNI_135_S_4676_MR_MPRAGE_br_raw_20120419112023754_126_S147672_I298456 | On a T1-weighted brain MRI of a 79-year-old male subject, we observed:
For the ventricles:
- no observable enlargement or abnormal growth in the 4th ventricle
- no signs of enlargement detected in the inf. lateral ventricle
- lateral ventricle appears structurally intact, with no evidence of enlargement
- external csf maintains its normal volume without signs of enlargement
- no abnormal enlargement observed in the 3rd ventricle
For the subcortical structures:
- mild atrophy of the pallidum
- moderate bilateral hippocampus atrophy, more pronounced on the right
- no observable atrophic alterations in the ventral dc
- between normal and mild right atrophy of the basal forebrain
- the putamen shows no structural abnormalities indicative of atrophy
- no evidence of atrophy or degeneration in the accumbens
- no evidence of atrophy or degeneration in the caudate
- thalamus appears structurally intact with no atrophic changes
- no signs of atrophy detected in the amygdala
For the cerebral cortex:
- occipital lobe maintains its normal morphology without atrophic features
- focal atrophy of insular cortex on anterior insula (between mild and moderate)
- parietal lobe remains normal, with no signs of tissue loss
- focal atrophy of temporal lobe on planum temporale (mild)
- atrophies of limbic cortex on entorhinal area (between mild and moderate) and parahippocampal gyrus (mild)
- focal atrophy of frontal lobe on supplementary motor cortex (between normal and mild) | AD |
ADNI_036_S_5063_MR_MPRAGE_br_raw_20130118120907075_34_S180473_I355515 | On a T1-weighted brain MRI of a 72-year-old female subject, we observed:
For the subcortical structures:
- caudate appears structurally intact with no atrophic changes
- no degenerative or atrophic changes noted in the pallidum
- severe bilateral amygdala atrophy, more pronounced on the left
- ventral dc presents with a healthy appearance, free from atrophy
- between normal and mild atrophy of the putamen, more pronounced on the left
- basal forebrain appears structurally intact with no atrophic changes
- no pathological changes consistent with atrophy detected in the hippocampus
- severe bilateral accumbens atrophy
- no signs of atrophy detected in the thalamus
For the ventricles:
- severe enlargement of the external csf
- 3rd ventricle remains within normal size parameters, with no enlargement detected
- no enlargement observed in the 4th ventricle
- severe bilateral inf. lateral ventricle enlargement
- lateral ventricle maintains its normal volume without signs of enlargement
For the cerebral cortex:
- moderate bilateral insular cortex atrophy, with focal volume loss observed in the following subregions: anterior insula (between moderate and severe) and posterior insula (between moderate and severe)
- between moderate and severe bilateral occipital lobe atrophy, with focal volume loss observed in the following subregions: calcarine cortex (between mild and moderate), lingual gyrus (between moderate and severe) and middle occipital gyrus (severe)
- moderate bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: anterior cingulate gyrus (moderate)
- mild atrophy of the parietal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: angular gyrus (between moderate and severe) and supramarginal gyrus (between normal and mild)
- focal atrophy of frontal lobe on opercular inf. frontal gyrus (between normal and mild)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (between normal and mild), middle temporal gyrus (severe), sup. temporal gyrus (between mild and moderate) and temporal pole (between normal and mild) | AD |
NIFD_3_S_0002_MR_T1_mprage__br_raw_20160518171333316_118_S442724_I709714 | On a T1-weighted brain MRI of a 64-year-old male subject, we observed:
For the subcortical structures:
- moderate atrophy of the hippocampus, more pronounced on the left
- the basal forebrain shows no structural abnormalities indicative of atrophy
- moderate bilateral pallidum atrophy, more pronounced on the left
- severe bilateral amygdala atrophy, more pronounced on the left
- moderate bilateral caudate atrophy, more pronounced on the left
- no observable atrophic alterations in the thalamus
- mild atrophy of the ventral dc, more pronounced on the left
- between moderate and severe bilateral putamen atrophy, more pronounced on the left
- between normal and mild atrophy of the accumbens, more pronounced on the left
For the cerebral cortex:
- focal atrophy of parietal lobe on angular gyrus (between moderate and severe)
- between mild and moderate atrophy of the limbic cortex, more pronounced on the left, with focal volume loss observed in the following subregions: entorhinal area (severe) and parahippocampal gyrus (between moderate and severe)
- between moderate and severe atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe) and posterior insula (between moderate and severe)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (severe), inf. temporal gyrus (severe), middle temporal gyrus (between moderate and severe), sup. temporal gyrus (mild) and temporal pole (severe)
- focal atrophy of occipital lobe on occipital fusiform gyrus (between moderate and severe)
- focal atrophy of frontal lobe on anterior orbital gyrus (between mild and moderate)
For the ventricles:
- no abnormal enlargement observed in the 3rd ventricle
- no enlargement observed in the lateral ventricle
- moderate enlargement of the external csf
- the 4th ventricle shows no structural abnormalities indicative of enlargement
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left | SV |
NIFD_3_S_0008_MR_T1_mprage_ND_br_raw_20160518225653834_34_S442955_I709965_dupl_4 | On a T1-weighted brain MRI of a 76-year-old male subject, we observed:
For the ventricles:
- severe enlargement of the 4th ventricle
- inf. lateral ventricle maintains its normal volume without signs of enlargement
- no observable enlargement or abnormal growth in the external csf
- mild enlargement of the lateral ventricle, more pronounced on the left
- moderate enlargement of the 3rd ventricle
For the cerebral cortex:
- atrophies of insular cortex on anterior insula (mild) and frontal operculum (between moderate and severe)
- no evidence of atrophy or degeneration in the parietal lobe
- no pathological changes consistent with atrophy detected in the occipital lobe
- no pathological changes consistent with atrophy detected in the temporal lobe
- between mild and moderate bilateral frontal lobe atrophy, with focal volume loss observed in the following subregions: middle frontal gyrus (between mild and moderate), precentral gyrus (between moderate and severe) and sup. frontal gyrus (between mild and moderate)
- atrophies of limbic cortex on anterior cingulate gyrus (mild) and posterior cingulate gyrus (mild)
For the subcortical structures:
- no signs of atrophy detected in the hippocampus
- amygdala maintains its normal morphology without atrophic features
- between normal and mild atrophy of the caudate, more pronounced on the left
- between normal and mild atrophy of the thalamus, more pronounced on the left
- between normal and mild left atrophy of the putamen
- between moderate and severe bilateral ventral dc atrophy, more pronounced on the left
- moderate atrophy of the pallidum, more pronounced on the left
- basal forebrain maintains its normal morphology without atrophic features
- between normal and mild left atrophy of the accumbens | PNFA |
NIFD_1_S_0123_MR_T1_mprage_S3_DIS3D_br_raw_20170817143341516_132_S598459_I892127 | On a T1-weighted brain MRI of a 62-year-old male subject, we observed:
For the cerebral cortex:
- severe atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe), central operculum (moderate) and frontal operculum (mild)
- severe bilateral frontal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: opercular inf. frontal gyrus (between normal and mild), orbital inf. frontal gyrus (between mild and moderate), triangular inf. frontal gyrus (moderate), middle frontal gyrus (severe), posterior orbital gyrus (between mild and moderate), precentral gyrus (between moderate and severe), sup. frontal gyrus (between normal and mild) and supplementary motor cortex (between moderate and severe)
- between mild and moderate atrophy of the limbic cortex, with focal volume loss observed in the following subregions: anterior cingulate gyrus (severe) and parahippocampal gyrus (mild)
- the parietal lobe shows no structural abnormalities indicative of atrophy
- occipital lobe remains normal, with no signs of tissue loss
- focal atrophy of temporal lobe on temporal pole (between normal and mild)
For the ventricles:
- severe bilateral lateral ventricle enlargement
- 4th ventricle is free from enlargement or excessive growth
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
- between mild and moderate enlargement of the external csf
- moderate enlargement of the 3rd ventricle
For the subcortical structures:
- no pathological changes consistent with atrophy detected in the basal forebrain
- between normal and mild left atrophy of the thalamus
- between moderate and severe bilateral amygdala atrophy, more pronounced on the left
- severe bilateral putamen atrophy, more pronounced on the left
- severe bilateral caudate atrophy, more pronounced on the left
- mild atrophy of the accumbens, more pronounced on the left
- no pathological changes consistent with atrophy detected in the hippocampus
- mild left atrophy of the pallidum
- the ventral dc shows no structural abnormalities indicative of atrophy | PNFA |
ADNI_135_S_5275_MR_MPRAGE_br_raw_20130805125009417_8_S197268_I384344_dupl_1 | On a T1-weighted brain MRI of a 78-year-old female subject, we observed:
For the cerebral cortex:
- focal atrophy of frontal lobe on sup. frontal gyrus medial segment (between mild and moderate)
- no pathological changes consistent with atrophy detected in the insular cortex
- focal atrophy of parietal lobe on angular gyrus (mild)
- atrophies of temporal lobe on planum polare (moderate) and sup. temporal gyrus (between normal and mild)
- atrophies of occipital lobe on cuneus (moderate) and occipital fusiform gyrus (between mild and moderate)
- no observable atrophic alterations in the limbic cortex
For the subcortical structures:
- moderate bilateral pallidum atrophy
- no signs of atrophy detected in the basal forebrain
- between mild and moderate right atrophy of the hippocampus
- between moderate and severe bilateral putamen atrophy, more pronounced on the left
- the accumbens shows no structural abnormalities indicative of atrophy
- between mild and moderate bilateral caudate atrophy, more pronounced on the left
- the thalamus shows no structural abnormalities indicative of atrophy
- moderate bilateral ventral dc atrophy
- no pathological changes consistent with atrophy detected in the amygdala
For the ventricles:
- no enlargement observed in the 4th ventricle
- no abnormal enlargement observed in the 3rd ventricle
- no pathological changes consistent with enlargement noted in the external csf
- no signs of enlargement detected in the inf. lateral ventricle
- between mild and moderate bilateral lateral ventricle enlargement | AD |
ADNI_036_S_4894_MR_MPRAGE_br_raw_20120810124944746_175_S160488_I323094 | On a T1-weighted brain MRI of a 61-year-old female subject, we observed:
For the cerebral cortex:
- insular cortex remains normal, with no signs of tissue loss
- atrophies of frontal lobe on opercular inf. frontal gyrus (between mild and moderate) and sup. frontal gyrus (between moderate and severe)
- between normal and mild atrophy of the limbic cortex, with focal volume loss observed in the following subregions: entorhinal area (between normal and mild)
- between mild and moderate atrophy of the parietal lobe, with focal volume loss observed in the following subregions: precuneus (between normal and mild) and supramarginal gyrus (between mild and moderate)
- moderate atrophy of the temporal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: inf. temporal gyrus (between mild and moderate) and middle temporal gyrus (mild)
- the occipital lobe shows no structural abnormalities indicative of atrophy
For the subcortical structures:
- no pathological changes consistent with atrophy detected in the accumbens
- between normal and mild atrophy of the putamen, more pronounced on the left
- between moderate and severe atrophy of the amygdala, more pronounced on the left
- the basal forebrain shows no structural abnormalities indicative of atrophy
- pallidum appears structurally intact with no atrophic changes
- no degenerative or atrophic changes noted in the ventral dc
- severe bilateral hippocampus atrophy, more pronounced on the left
- the thalamus shows no structural abnormalities indicative of atrophy
- moderate bilateral caudate atrophy
For the ventricles:
- 4th ventricle is free from enlargement or excessive growth
- no pathological changes consistent with enlargement noted in the 3rd ventricle
- no abnormal enlargement observed in the lateral ventricle
- between moderate and severe enlargement of the inf. lateral ventricle, more pronounced on the left
- between mild and moderate enlargement of the external csf | AD |
NIFD_1_S_0056_MR_t1_mprage_S3_DIS3D_br_raw_20111019194910586_85_S125860_I261681_dupl_2 | On a T1-weighted brain MRI of a 59-year-old male subject, we observed:
For the ventricles:
- severe bilateral lateral ventricle enlargement
- external csf is free from enlargement or excessive growth
- moderate bilateral inf. lateral ventricle enlargement
- 4th ventricle is free from enlargement or excessive growth
- 3rd ventricle appears structurally intact, with no evidence of enlargement
For the cerebral cortex:
- moderate atrophy of the parietal lobe, with focal volume loss observed in the following subregions: precuneus (between mild and moderate) and supramarginal gyrus (mild)
- occipital lobe maintains its normal morphology without atrophic features
- mild bilateral frontal lobe atrophy, with focal volume loss observed in the following subregions: gyrus rectus (mild), posterior orbital gyrus (between mild and moderate) and sup. frontal gyrus (between moderate and severe)
- focal atrophy of limbic cortex on anterior cingulate gyrus (between normal and mild)
- focal atrophy of temporal lobe on planum polare (mild)
- atrophies of insular cortex on central operculum (between normal and mild) and parietal operculum (between moderate and severe)
For the subcortical structures:
- severe bilateral thalamus atrophy, more pronounced on the left
- no evidence of atrophy or degeneration in the basal forebrain
- between mild and moderate bilateral pallidum atrophy
- putamen appears structurally intact with no atrophic changes
- moderate bilateral accumbens atrophy
- between mild and moderate atrophy of the hippocampus
- between normal and mild atrophy of the ventral dc, more pronounced on the left
- moderate bilateral caudate atrophy, more pronounced on the left
- moderate bilateral amygdala atrophy | BV |
ADNI_019_S_4835_MR_MPRAGE_br_raw_20120711140807158_62_S157253_I315857 | On a T1-weighted brain MRI of a 80-year-old male subject, we observed:
For the ventricles:
- lateral ventricle is free from enlargement or excessive growth
- no enlargement observed in the 3rd ventricle
- no abnormal enlargement observed in the external csf
- no abnormal enlargement observed in the inf. lateral ventricle
- no abnormal enlargement observed in the 4th ventricle
For the cerebral cortex:
- no evidence of atrophy or degeneration in the frontal lobe
- no pathological changes consistent with atrophy detected in the occipital lobe
- temporal lobe appears structurally intact with no atrophic changes
- parietal lobe maintains its normal morphology without atrophic features
- insular cortex maintains its normal morphology without atrophic features
- focal atrophy of limbic cortex on posterior cingulate gyrus (between mild and moderate)
For the subcortical structures:
- basal forebrain remains normal, with no signs of tissue loss
- accumbens presents with a healthy appearance, free from atrophy
- thalamus remains normal, with no signs of tissue loss
- no observable atrophic alterations in the hippocampus
- no degenerative or atrophic changes noted in the putamen
- no pathological changes consistent with atrophy detected in the pallidum
- amygdala remains normal, with no signs of tissue loss
- caudate appears structurally intact with no atrophic changes
- ventral dc appears structurally intact with no atrophic changes | CN |
NIFD_1_S_0169_MR_T1_mprage_S3_DIS3D_br_raw_20140701110602779_92_S223672_I433733_dupl_10 | On a T1-weighted brain MRI of a 74-year-old female subject, we observed:
For the cerebral cortex:
- mild atrophy of the frontal lobe, more pronounced on the right, with focal volume loss observed in the following subregions: sup. frontal gyrus (between moderate and severe)
- focal atrophy of limbic cortex on parahippocampal gyrus (between normal and mild)
- atrophies of occipital lobe on cuneus (between mild and moderate) and occipital pole (between normal and mild)
- no evidence of atrophy or degeneration in the parietal lobe
- moderate bilateral insular cortex atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (between normal and mild) and central operculum (moderate)
- atrophies of temporal lobe on planum temporale (moderate), sup. temporal gyrus (between mild and moderate) and transverse temporal gyrus (between normal and mild)
For the subcortical structures:
- no observable atrophic alterations in the amygdala
- caudate maintains its normal morphology without atrophic features
- basal forebrain appears structurally intact with no atrophic changes
- no evidence of atrophy or degeneration in the ventral dc
- no observable atrophic alterations in the pallidum
- no observable atrophic alterations in the accumbens
- thalamus presents with a healthy appearance, free from atrophy
- between moderate and severe bilateral hippocampus atrophy, more pronounced on the right
- no degenerative or atrophic changes noted in the putamen
For the ventricles:
- no enlargement observed in the lateral ventricle
- 4th ventricle appears structurally intact, with no evidence of enlargement
- no signs of enlargement detected in the 3rd ventricle
- no signs of enlargement detected in the external csf
- between normal and mild right enlargement of the inf. lateral ventricle | PNFA |
NIFD_2_S_0031_MR_MT1__GradWarp__N3m_Br_20130514103437416_S188985_I372252 | On a T1-weighted brain MRI of a 66-year-old female subject, we observed:
For the cerebral cortex:
- severe atrophy of the limbic cortex, more pronounced on the right, with focal volume loss observed in the following subregions: anterior cingulate gyrus (severe)
- between moderate and severe atrophy of the insular cortex, more pronounced on the right, with focal volume loss observed in the following subregions: anterior insula (severe) and frontal operculum (moderate)
- no signs of atrophy detected in the parietal lobe
- severe atrophy of the frontal lobe, more pronounced on the right, with focal volume loss observed in the following subregions: gyrus rectus (between moderate and severe), opercular inf. frontal gyrus (severe), medial frontal cortex (mild), anterior orbital gyrus (between moderate and severe), lateral orbital gyrus (between moderate and severe), medial orbital gyrus (severe), posterior orbital gyrus (severe), sup. frontal gyrus (between normal and mild), sup. frontal gyrus medial segment (severe), triangular inf. frontal gyrus (mild) and orbital inf. frontal gyrus (mild)
- no degenerative or atrophic changes noted in the occipital lobe
- atrophies of temporal lobe on middle temporal gyrus (between normal and mild) and temporal pole (between moderate and severe)
For the ventricles:
- between moderate and severe enlargement of the 3rd ventricle
- mild bilateral lateral ventricle enlargement
- moderate enlargement of the external csf
- between moderate and severe enlargement of the inf. lateral ventricle, more pronounced on the right
- no pathological changes consistent with enlargement noted in the 4th ventricle
For the subcortical structures:
- no pathological changes consistent with atrophy detected in the ventral dc
- severe bilateral caudate atrophy, more pronounced on the right
- basal forebrain maintains its normal morphology without atrophic features
- severe bilateral amygdala atrophy, more pronounced on the right
- between mild and moderate right atrophy of the thalamus
- severe bilateral accumbens atrophy, more pronounced on the right
- between mild and moderate atrophy of the pallidum, more pronounced on the right
- severe bilateral putamen atrophy, more pronounced on the right
- moderate right atrophy of the hippocampus | BV |
NIFD_2_S_0008_MR_MT1__GradWarp__N3m_Br_20111229190047421_S133665_I274730 | On a T1-weighted brain MRI of a 64-year-old female subject, we observed:
For the ventricles:
- no enlargement observed in the lateral ventricle
- 3rd ventricle maintains its normal volume without signs of enlargement
- the inf. lateral ventricle shows no structural abnormalities indicative of enlargement
- no abnormal enlargement observed in the 4th ventricle
- no pathological changes consistent with enlargement noted in the external csf
For the cerebral cortex:
- no evidence of atrophy or degeneration in the frontal lobe
- the limbic cortex shows no structural abnormalities indicative of atrophy
- occipital lobe presents with a healthy appearance, free from atrophy
- insular cortex remains normal, with no signs of tissue loss
- moderate bilateral temporal lobe atrophy, with focal volume loss observed in the following subregions: middle temporal gyrus (mild), sup. temporal gyrus (between mild and moderate) and inf. temporal gyrus (between normal and mild)
- the parietal lobe shows no structural abnormalities indicative of atrophy
For the subcortical structures:
- no observable atrophic alterations in the hippocampus
- no evidence of atrophy or degeneration in the thalamus
- between normal and mild left atrophy of the accumbens
- amygdala appears structurally intact with no atrophic changes
- no pathological changes consistent with atrophy detected in the pallidum
- no signs of atrophy detected in the putamen
- basal forebrain appears structurally intact with no atrophic changes
- mild bilateral ventral dc atrophy
- caudate maintains its normal morphology without atrophic features | CN |
NIFD_1_S_0084_MR_T1_mprage_S5_DIS3D_br_raw_20120819205904146_39_S161569_I324836_dupl_3 | On a T1-weighted brain MRI of a 53-year-old male subject, we observed:
For the subcortical structures:
- moderate left atrophy of the hippocampus
- the caudate shows no structural abnormalities indicative of atrophy
- severe atrophy of the amygdala, more pronounced on the left
- no signs of atrophy detected in the ventral dc
- severe bilateral accumbens atrophy, more pronounced on the left
- no signs of atrophy detected in the thalamus
- no degenerative or atrophic changes noted in the basal forebrain
- no observable atrophic alterations in the pallidum
- between normal and mild left atrophy of the putamen
For the cerebral cortex:
- severe atrophy of the temporal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: temporal pole (severe), inf. temporal gyrus (moderate) and middle temporal gyrus (between mild and moderate)
- atrophies of frontal lobe on gyrus rectus (mild) and medial frontal cortex (between mild and moderate)
- between mild and moderate atrophy of the limbic cortex, more pronounced on the left, with focal volume loss observed in the following subregions: entorhinal area (between mild and moderate) and anterior cingulate gyrus (mild)
- occipital lobe appears structurally intact with no atrophic changes
- focal atrophy of insular cortex on anterior insula (between mild and moderate)
- atrophies of parietal lobe on angular gyrus (between normal and mild) and precuneus (between mild and moderate)
For the ventricles:
- between mild and moderate enlargement of the external csf
- 4th ventricle remains within normal size parameters, with no enlargement detected
- between mild and moderate enlargement of the inf. lateral ventricle, more pronounced on the left
- no observable enlargement or abnormal growth in the lateral ventricle
- the 3rd ventricle shows no structural abnormalities indicative of enlargement | SV |
ADNI_126_S_4494_MR_Accelerated_Sag_IR-SPGR__br_raw_20120131123025629_91_S138966_I281601 | On a T1-weighted brain MRI of a 71-year-old male subject, we observed:
For the cerebral cortex:
- the temporal lobe shows no structural abnormalities indicative of atrophy
- focal atrophy of parietal lobe on postcentral gyrus medial segment (mild)
- insular cortex presents with a healthy appearance, free from atrophy
- focal atrophy of limbic cortex on entorhinal area (moderate)
- atrophies of frontal lobe on posterior orbital gyrus (between normal and mild) and precentral gyrus medial segment (mild)
- atrophies of occipital lobe on middle occipital gyrus (mild) and occipital pole (mild)
For the subcortical structures:
- severe bilateral amygdala atrophy
- moderate bilateral hippocampus atrophy
- accumbens presents with a healthy appearance, free from atrophy
- no evidence of atrophy or degeneration in the caudate
- no degenerative or atrophic changes noted in the pallidum
- no observable atrophic alterations in the ventral dc
- thalamus appears structurally intact with no atrophic changes
- no degenerative or atrophic changes noted in the putamen
- basal forebrain appears structurally intact with no atrophic changes
For the ventricles:
- no enlargement observed in the lateral ventricle
- 3rd ventricle is free from enlargement or excessive growth
- external csf remains within normal size parameters, with no enlargement detected
- 4th ventricle is free from enlargement or excessive growth
- moderate bilateral inf. lateral ventricle enlargement | AD |
NIFD_1_S_0099_MR_T1_mprage_S3_DIS3D_br_raw_20120819131043923_110_S161401_I324640_dupl_12 | On a T1-weighted brain MRI of a 69-year-old female subject, we observed:
For the subcortical structures:
- between mild and moderate bilateral accumbens atrophy
- no evidence of atrophy or degeneration in the basal forebrain
- severe bilateral caudate atrophy
- severe bilateral putamen atrophy, more pronounced on the left
- between normal and mild left atrophy of the hippocampus
- between mild and moderate bilateral pallidum atrophy, more pronounced on the left
- mild left atrophy of the amygdala
- between normal and mild atrophy of the thalamus, more pronounced on the left
- between normal and mild bilateral ventral dc atrophy
For the cerebral cortex:
- focal atrophy of frontal lobe on triangular inf. frontal gyrus (moderate)
- focal atrophy of occipital lobe on middle occipital gyrus (between normal and mild)
- no pathological changes consistent with atrophy detected in the parietal lobe
- no pathological changes consistent with atrophy detected in the limbic cortex
- insular cortex presents with a healthy appearance, free from atrophy
- focal atrophy of temporal lobe on sup. temporal gyrus (between mild and moderate)
For the ventricles:
- the 4th ventricle shows no structural abnormalities indicative of enlargement
- moderate enlargement of the external csf
- between normal and mild left enlargement of the lateral ventricle
- no pathological changes consistent with enlargement noted in the inf. lateral ventricle
- no signs of enlargement detected in the 3rd ventricle | PNFA |
ADNI_100_S_5246_MR_MPRAGE_br_raw_20130823142052575_107_S199007_I387095 | On a T1-weighted brain MRI of a 66-year-old female subject, we observed:
For the ventricles:
- severe enlargement of the external csf
- between moderate and severe enlargement of the 3rd ventricle
- between normal and mild enlargement of the lateral ventricle
- 4th ventricle maintains its normal volume without signs of enlargement
- between moderate and severe bilateral inf. lateral ventricle enlargement, more pronounced on the right
For the subcortical structures:
- moderate bilateral hippocampus atrophy, more pronounced on the right
- no pathological changes consistent with atrophy detected in the caudate
- moderate bilateral ventral dc atrophy
- no signs of atrophy detected in the accumbens
- between moderate and severe atrophy of the amygdala, more pronounced on the right
- no evidence of atrophy or degeneration in the putamen
- pallidum presents with a healthy appearance, free from atrophy
- no degenerative or atrophic changes noted in the basal forebrain
- mild bilateral thalamus atrophy
For the cerebral cortex:
- mild atrophy of the limbic cortex, more pronounced on the left, with focal volume loss observed in the following subregions: entorhinal area (between moderate and severe) and parahippocampal gyrus (mild)
- moderate bilateral temporal lobe atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: planum temporale (between moderate and severe), middle temporal gyrus (severe) and transverse temporal gyrus (severe)
- focal atrophy of occipital lobe on cuneus (between normal and mild)
- severe bilateral insular cortex atrophy, with focal volume loss observed in the following subregions: anterior insula (moderate), central operculum (moderate) and parietal operculum (between mild and moderate)
- atrophies of frontal lobe on anterior orbital gyrus (between normal and mild), sup. frontal gyrus (mild), sup. frontal gyrus medial segment (mild) and triangular inf. frontal gyrus (moderate)
- focal atrophy of parietal lobe on precuneus (between normal and mild) | CN |
NIFD_2_S_0018_MR_MT1__GradWarp__N3m_Br_20120820135438042_S151967_I324982 | On a T1-weighted brain MRI of a 64-year-old female subject, we observed:
For the cerebral cortex:
- limbic cortex presents with a healthy appearance, free from atrophy
- no degenerative or atrophic changes noted in the insular cortex
- occipital lobe remains normal, with no signs of tissue loss
- temporal lobe maintains its normal morphology without atrophic features
- atrophies of frontal lobe on triangular inf. frontal gyrus (between normal and mild) and lateral orbital gyrus (severe)
- no pathological changes consistent with atrophy detected in the parietal lobe
For the subcortical structures:
- the basal forebrain shows no structural abnormalities indicative of atrophy
- caudate remains normal, with no signs of tissue loss
- accumbens presents with a healthy appearance, free from atrophy
- putamen presents with a healthy appearance, free from atrophy
- no pathological changes consistent with atrophy detected in the amygdala
- no evidence of atrophy or degeneration in the hippocampus
- no pathological changes consistent with atrophy detected in the thalamus
- pallidum presents with a healthy appearance, free from atrophy
- the ventral dc shows no structural abnormalities indicative of atrophy
For the ventricles:
- between normal and mild left enlargement of the lateral ventricle
- no observable enlargement or abnormal growth in the inf. lateral ventricle
- no observable enlargement or abnormal growth in the 4th ventricle
- external csf maintains its normal volume without signs of enlargement
- 3rd ventricle is free from enlargement or excessive growth | CN |
ADNI_135_S_5275_MR_MPRAGE_br_raw_20130805125009417_8_S197268_I384344 | On a T1-weighted brain MRI of a 78-year-old female subject, we observed:
For the subcortical structures:
- between moderate and severe bilateral putamen atrophy, more pronounced on the left
- moderate bilateral ventral dc atrophy
- between mild and moderate right atrophy of the hippocampus
- accumbens remains normal, with no signs of tissue loss
- amygdala presents with a healthy appearance, free from atrophy
- between mild and moderate bilateral caudate atrophy, more pronounced on the left
- basal forebrain remains normal, with no signs of tissue loss
- moderate bilateral pallidum atrophy
- no degenerative or atrophic changes noted in the thalamus
For the ventricles:
- between mild and moderate bilateral lateral ventricle enlargement
- no observable enlargement or abnormal growth in the inf. lateral ventricle
- 4th ventricle maintains its normal volume without signs of enlargement
- no pathological changes consistent with enlargement noted in the 3rd ventricle
- external csf maintains its normal volume without signs of enlargement
For the cerebral cortex:
- atrophies of occipital lobe on cuneus (moderate) and occipital fusiform gyrus (between mild and moderate)
- focal atrophy of frontal lobe on sup. frontal gyrus medial segment (between mild and moderate)
- atrophies of temporal lobe on planum polare (moderate) and sup. temporal gyrus (between normal and mild)
- no pathological changes consistent with atrophy detected in the insular cortex
- the limbic cortex shows no structural abnormalities indicative of atrophy
- focal atrophy of parietal lobe on angular gyrus (mild) | AD |
NIFD_2_S_0021_MR_MT1__GradWarp__N3m_Br_20130114173911629_S160243_I355049_dupl_2 | On a T1-weighted brain MRI of a 60-year-old male subject, we observed:
For the subcortical structures:
- no signs of atrophy detected in the pallidum
- hippocampus presents with a healthy appearance, free from atrophy
- no pathological changes consistent with atrophy detected in the amygdala
- putamen appears structurally intact with no atrophic changes
- no signs of atrophy detected in the accumbens
- the caudate shows no structural abnormalities indicative of atrophy
- basal forebrain appears structurally intact with no atrophic changes
- no evidence of atrophy or degeneration in the ventral dc
- thalamus remains normal, with no signs of tissue loss
For the ventricles:
- 3rd ventricle appears structurally intact, with no evidence of enlargement
- no enlargement observed in the external csf
- between normal and mild enlargement of the 4th ventricle
- no observable enlargement or abnormal growth in the lateral ventricle
- no signs of enlargement detected in the inf. lateral ventricle
For the cerebral cortex:
- no degenerative or atrophic changes noted in the parietal lobe
- no degenerative or atrophic changes noted in the temporal lobe
- focal atrophy of insular cortex on parietal operculum (between normal and mild)
- occipital lobe maintains its normal morphology without atrophic features
- focal atrophy of frontal lobe on opercular inf. frontal gyrus (moderate)
- atrophies of limbic cortex on middle cingulate gyrus (mild) and posterior cingulate gyrus (between normal and mild) | BV |
NIFD_1_S_0009_MR_t1_mprage_S3_DIS3D_br_raw_20110203200504338_149_S98892_I215776 | On a T1-weighted brain MRI of a 67-year-old female subject, we observed:
For the cerebral cortex:
- atrophies of limbic cortex on entorhinal area (between moderate and severe) and parahippocampal gyrus (between mild and moderate)
- parietal lobe remains normal, with no signs of tissue loss
- severe bilateral temporal lobe atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: fusiform gyrus (between moderate and severe), inf. temporal gyrus (severe), middle temporal gyrus (moderate) and temporal pole (severe)
- focal atrophy of frontal lobe on gyrus rectus (between normal and mild)
- between mild and moderate atrophy of the insular cortex, more pronounced on the right, with focal volume loss observed in the following subregions: anterior insula (between moderate and severe) and posterior insula (between moderate and severe)
- focal atrophy of occipital lobe on calcarine cortex (mild)
For the subcortical structures:
- between mild and moderate bilateral thalamus atrophy
- no observable atrophic alterations in the basal forebrain
- severe bilateral accumbens atrophy, more pronounced on the right
- mild bilateral ventral dc atrophy
- severe bilateral pallidum atrophy, more pronounced on the right
- severe bilateral hippocampus atrophy, more pronounced on the right
- mild atrophy of the caudate, more pronounced on the right
- moderate bilateral putamen atrophy, more pronounced on the right
- severe bilateral amygdala atrophy, more pronounced on the right
For the ventricles:
- no observable enlargement or abnormal growth in the external csf
- between moderate and severe bilateral lateral ventricle enlargement
- 4th ventricle maintains its normal volume without signs of enlargement
- between moderate and severe enlargement of the 3rd ventricle
- severe bilateral inf. lateral ventricle enlargement | SV |
NIFD_3_S_0011_MR_T1_mprage_ND_S3_DIS3D__br_raw_20160519104824325_34_S443835_I710941_dupl_9 | On a T1-weighted brain MRI of a 65-year-old male subject, we observed:
For the cerebral cortex:
- severe bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: entorhinal area (severe), anterior cingulate gyrus (between normal and mild), middle cingulate gyrus (between normal and mild), posterior cingulate gyrus (between normal and mild) and parahippocampal gyrus (between mild and moderate)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (between normal and mild), planum polare (moderate), inf. temporal gyrus (severe), middle temporal gyrus (moderate), sup. temporal gyrus (mild) and temporal pole (severe)
- focal atrophy of frontal lobe on lateral orbital gyrus (mild)
- no evidence of atrophy or degeneration in the parietal lobe
- mild atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: posterior insula (between moderate and severe) and central operculum (mild)
- no signs of atrophy detected in the occipital lobe
For the ventricles:
- the external csf shows no structural abnormalities indicative of enlargement
- 4th ventricle maintains its normal volume without signs of enlargement
- between moderate and severe enlargement of the lateral ventricle, more pronounced on the left
- between mild and moderate enlargement of the 3rd ventricle
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
For the subcortical structures:
- no evidence of atrophy or degeneration in the thalamus
- between normal and mild atrophy of the hippocampus, more pronounced on the left
- moderate left atrophy of the caudate
- pallidum remains normal, with no signs of tissue loss
- between mild and moderate atrophy of the accumbens, more pronounced on the left
- putamen presents with a healthy appearance, free from atrophy
- no degenerative or atrophic changes noted in the ventral dc
- severe bilateral amygdala atrophy, more pronounced on the left
- basal forebrain remains normal, with no signs of tissue loss | SV |
NIFD_1_S_0015_MR_t1_mprage_S3_DIS3D_br_raw_20110204144009602_54_S99058_I215997_dupl_1 | On a T1-weighted brain MRI of a 63-year-old male subject, we observed:
For the ventricles:
- between moderate and severe enlargement of the external csf
- severe enlargement of the 3rd ventricle
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
- no observable enlargement or abnormal growth in the lateral ventricle
- the 4th ventricle shows no structural abnormalities indicative of enlargement
For the cerebral cortex:
- severe bilateral insular cortex atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (between moderate and severe) and frontal operculum (between normal and mild)
- the occipital lobe shows no structural abnormalities indicative of atrophy
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (severe), planum polare (moderate), inf. temporal gyrus (between moderate and severe), middle temporal gyrus (mild), sup. temporal gyrus (moderate) and temporal pole (severe)
- mild atrophy of the frontal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: anterior orbital gyrus (between normal and mild) and sup. frontal gyrus medial segment (moderate)
- focal atrophy of parietal lobe on postcentral gyrus medial segment (moderate)
- moderate bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: entorhinal area (severe)
For the subcortical structures:
- severe bilateral amygdala atrophy, more pronounced on the left
- moderate bilateral accumbens atrophy, more pronounced on the left
- caudate appears structurally intact with no atrophic changes
- between normal and mild left atrophy of the pallidum
- no pathological changes consistent with atrophy detected in the thalamus
- between moderate and severe left atrophy of the putamen
- severe atrophy of the hippocampus, more pronounced on the left
- basal forebrain maintains its normal morphology without atrophic features
- no signs of atrophy detected in the ventral dc | SV |
NIFD_1_S_0085_MR_T1_mprage_S3_DIS3D_br_raw_20120307000133150_31_S143023_I288641_dupl_4 | On a T1-weighted brain MRI of a 47-year-old female subject, we observed:
For the cerebral cortex:
- focal atrophy of temporal lobe on temporal pole (between moderate and severe)
- mild atrophy of the frontal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: middle frontal gyrus (between moderate and severe), lateral orbital gyrus (between normal and mild) and sup. frontal gyrus medial segment (between normal and mild)
- focal atrophy of parietal lobe on precuneus (between normal and mild)
- the occipital lobe shows no structural abnormalities indicative of atrophy
- no degenerative or atrophic changes noted in the insular cortex
- no pathological changes consistent with atrophy detected in the limbic cortex
For the subcortical structures:
- no degenerative or atrophic changes noted in the basal forebrain
- mild atrophy of the pallidum, more pronounced on the left
- between normal and mild atrophy of the ventral dc, more pronounced on the left
- between normal and mild left atrophy of the amygdala
- between moderate and severe bilateral hippocampus atrophy
- between moderate and severe atrophy of the thalamus, more pronounced on the left
- between normal and mild left atrophy of the putamen
- accumbens maintains its normal morphology without atrophic features
- between normal and mild atrophy of the caudate, more pronounced on the left
For the ventricles:
- moderate enlargement of the 3rd ventricle
- 4th ventricle is free from enlargement or excessive growth
- no signs of enlargement detected in the inf. lateral ventricle
- severe enlargement of the external csf
- lateral ventricle is free from enlargement or excessive growth | BV |
ADNI_014_S_4577_MR_MPRAGE_br_raw_20120322131214248_143_S144503_I291667 | On a T1-weighted brain MRI of a 85-year-old male subject, we observed:
For the subcortical structures:
- no pathological changes consistent with atrophy detected in the putamen
- no degenerative or atrophic changes noted in the ventral dc
- no pathological changes consistent with atrophy detected in the thalamus
- no signs of atrophy detected in the caudate
- amygdala presents with a healthy appearance, free from atrophy
- no observable atrophic alterations in the basal forebrain
- hippocampus remains normal, with no signs of tissue loss
- pallidum presents with a healthy appearance, free from atrophy
- no evidence of atrophy or degeneration in the accumbens
For the ventricles:
- 3rd ventricle appears structurally intact, with no evidence of enlargement
- external csf is free from enlargement or excessive growth
- inf. lateral ventricle appears structurally intact, with no evidence of enlargement
- the lateral ventricle shows no structural abnormalities indicative of enlargement
- no signs of enlargement detected in the 4th ventricle
For the cerebral cortex:
- temporal lobe appears structurally intact with no atrophic changes
- atrophies of frontal lobe on precentral gyrus (mild) and supplementary motor cortex (between mild and moderate)
- no pathological changes consistent with atrophy detected in the insular cortex
- parietal lobe maintains its normal morphology without atrophic features
- no degenerative or atrophic changes noted in the limbic cortex
- between mild and moderate atrophy of the occipital lobe, more pronounced on the left, with focal volume loss observed in the following subregions: occipital fusiform gyrus (between mild and moderate), inf. occipital gyrus (mild) and occipital pole (mild) | CN |
ADNI_007_S_4488_MR_Accelerated_SAG_IR-SPGR__br_raw_20120131104026380_93_S138944_I281559 | On a T1-weighted brain MRI of a 73-year-old male subject, we observed:
For the ventricles:
- the 4th ventricle shows no structural abnormalities indicative of enlargement
- inf. lateral ventricle maintains its normal volume without signs of enlargement
- no abnormal enlargement observed in the external csf
- lateral ventricle maintains its normal volume without signs of enlargement
- no pathological changes consistent with enlargement noted in the 3rd ventricle
For the subcortical structures:
- no signs of atrophy detected in the putamen
- pallidum appears structurally intact with no atrophic changes
- no evidence of atrophy or degeneration in the thalamus
- no evidence of atrophy or degeneration in the amygdala
- basal forebrain maintains its normal morphology without atrophic features
- accumbens presents with a healthy appearance, free from atrophy
- ventral dc presents with a healthy appearance, free from atrophy
- caudate remains normal, with no signs of tissue loss
- the hippocampus shows no structural abnormalities indicative of atrophy
For the cerebral cortex:
- focal atrophy of limbic cortex on middle cingulate gyrus (between mild and moderate)
- occipital lobe remains normal, with no signs of tissue loss
- frontal lobe remains normal, with no signs of tissue loss
- focal atrophy of parietal lobe on sup. parietal lobule (moderate)
- no pathological changes consistent with atrophy detected in the insular cortex
- the temporal lobe shows no structural abnormalities indicative of atrophy | CN |
ADNI_094_S_4560_MR_Accelerated_SAG_IR-SPGR__br_raw_20120326195612702_23_S144258_I291214 | On a T1-weighted brain MRI of a 70-year-old female subject, we observed:
For the cerebral cortex:
- temporal lobe maintains its normal morphology without atrophic features
- no degenerative or atrophic changes noted in the parietal lobe
- atrophies of occipital lobe on calcarine cortex (moderate) and occipital pole (between normal and mild)
- no signs of atrophy detected in the limbic cortex
- between normal and mild atrophy of the insular cortex, with focal volume loss observed in the following subregions: parietal operculum (between normal and mild)
- focal atrophy of frontal lobe on anterior orbital gyrus (between normal and mild)
For the ventricles:
- between normal and mild enlargement of the external csf
- no enlargement observed in the inf. lateral ventricle
- 3rd ventricle maintains its normal volume without signs of enlargement
- no enlargement observed in the lateral ventricle
- the 4th ventricle shows no structural abnormalities indicative of enlargement
For the subcortical structures:
- amygdala maintains its normal morphology without atrophic features
- ventral dc presents with a healthy appearance, free from atrophy
- pallidum remains normal, with no signs of tissue loss
- no pathological changes consistent with atrophy detected in the basal forebrain
- no signs of atrophy detected in the hippocampus
- no signs of atrophy detected in the thalamus
- no degenerative or atrophic changes noted in the caudate
- no pathological changes consistent with atrophy detected in the accumbens
- putamen maintains its normal morphology without atrophic features | CN |
NIFD_3_S_0002_MR_T1_mprage__br_raw_20160518171333316_118_S442724_I709714_dupl_1 | On a T1-weighted brain MRI of a 64-year-old male subject, we observed:
For the subcortical structures:
- no pathological changes consistent with atrophy detected in the thalamus
- severe bilateral amygdala atrophy, more pronounced on the left
- moderate bilateral pallidum atrophy, more pronounced on the left
- moderate bilateral caudate atrophy, more pronounced on the left
- moderate atrophy of the hippocampus, more pronounced on the left
- mild atrophy of the ventral dc, more pronounced on the left
- basal forebrain presents with a healthy appearance, free from atrophy
- between moderate and severe bilateral putamen atrophy, more pronounced on the left
- between normal and mild atrophy of the accumbens, more pronounced on the left
For the ventricles:
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
- no observable enlargement or abnormal growth in the 3rd ventricle
- no abnormal enlargement observed in the 4th ventricle
- lateral ventricle remains within normal size parameters, with no enlargement detected
- moderate enlargement of the external csf
For the cerebral cortex:
- focal atrophy of parietal lobe on angular gyrus (between moderate and severe)
- focal atrophy of frontal lobe on anterior orbital gyrus (between mild and moderate)
- focal atrophy of occipital lobe on occipital fusiform gyrus (between moderate and severe)
- between mild and moderate atrophy of the limbic cortex, more pronounced on the left, with focal volume loss observed in the following subregions: entorhinal area (severe) and parahippocampal gyrus (between moderate and severe)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (severe), inf. temporal gyrus (severe), middle temporal gyrus (between moderate and severe), sup. temporal gyrus (mild) and temporal pole (severe)
- between moderate and severe atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe) and posterior insula (between moderate and severe) | SV |
NIFD_3_S_0012_MR_T1_mprage_S3_DIS3D_br_raw_20160520111537809_160_S212086_I413590_dupl_8 | On a T1-weighted brain MRI of a 64-year-old male subject, we observed:
For the ventricles:
- between normal and mild enlargement of the external csf
- no signs of enlargement detected in the 4th ventricle
- no enlargement observed in the 3rd ventricle
- no enlargement observed in the lateral ventricle
- between mild and moderate bilateral inf. lateral ventricle enlargement
For the cerebral cortex:
- severe bilateral insular cortex atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe), frontal operculum (between moderate and severe) and parietal operculum (between moderate and severe)
- no observable atrophic alterations in the parietal lobe
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: inf. temporal gyrus (mild), middle temporal gyrus (moderate), temporal pole (severe) and fusiform gyrus (between normal and mild)
- no evidence of atrophy or degeneration in the occipital lobe
- between moderate and severe atrophy of the frontal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: frontal pole (between moderate and severe), gyrus rectus (between normal and mild), opercular inf. frontal gyrus (moderate), orbital inf. frontal gyrus (between moderate and severe), middle frontal gyrus (mild), lateral orbital gyrus (moderate) and sup. frontal gyrus medial segment (between normal and mild)
- mild atrophy of the limbic cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior cingulate gyrus (moderate)
For the subcortical structures:
- no observable atrophic alterations in the pallidum
- between normal and mild left atrophy of the hippocampus
- caudate appears structurally intact with no atrophic changes
- the ventral dc shows no structural abnormalities indicative of atrophy
- basal forebrain maintains its normal morphology without atrophic features
- mild left atrophy of the putamen
- accumbens remains normal, with no signs of tissue loss
- thalamus maintains its normal morphology without atrophic features
- moderate atrophy of the amygdala, more pronounced on the left | PNFA |
NIFD_3_S_0008_MR_T1_mprage_ND_br_raw_20160518225653834_34_S442955_I709965_dupl_8 | On a T1-weighted brain MRI of a 76-year-old male subject, we observed:
For the cerebral cortex:
- the temporal lobe shows no structural abnormalities indicative of atrophy
- no observable atrophic alterations in the occipital lobe
- atrophies of insular cortex on anterior insula (mild) and frontal operculum (between moderate and severe)
- between mild and moderate bilateral frontal lobe atrophy, with focal volume loss observed in the following subregions: middle frontal gyrus (between mild and moderate), precentral gyrus (between moderate and severe) and sup. frontal gyrus (between mild and moderate)
- no signs of atrophy detected in the parietal lobe
- atrophies of limbic cortex on anterior cingulate gyrus (mild) and posterior cingulate gyrus (mild)
For the subcortical structures:
- between normal and mild left atrophy of the accumbens
- amygdala maintains its normal morphology without atrophic features
- between normal and mild atrophy of the caudate, more pronounced on the left
- between normal and mild atrophy of the thalamus, more pronounced on the left
- basal forebrain maintains its normal morphology without atrophic features
- moderate atrophy of the pallidum, more pronounced on the left
- between moderate and severe bilateral ventral dc atrophy, more pronounced on the left
- between normal and mild left atrophy of the putamen
- no degenerative or atrophic changes noted in the hippocampus
For the ventricles:
- no observable enlargement or abnormal growth in the external csf
- mild enlargement of the lateral ventricle, more pronounced on the left
- no observable enlargement or abnormal growth in the inf. lateral ventricle
- severe enlargement of the 4th ventricle
- moderate enlargement of the 3rd ventricle | PNFA |
ADNI_130_S_4997_MR_MPRAGE_br_raw_20121120141641968_22_S175145_I347410_dupl_1 | On a T1-weighted brain MRI of a 61-year-old female subject, we observed:
For the ventricles:
- between mild and moderate left enlargement of the inf. lateral ventricle
- mild left enlargement of the lateral ventricle
- the external csf shows no structural abnormalities indicative of enlargement
- 4th ventricle is free from enlargement or excessive growth
- no pathological changes consistent with enlargement noted in the 3rd ventricle
For the cerebral cortex:
- between normal and mild atrophy of the frontal lobe, more pronounced on the left, with focal volume loss observed in the following subregions: middle frontal gyrus (moderate)
- focal atrophy of occipital lobe on middle occipital gyrus (between normal and mild)
- focal atrophy of limbic cortex on anterior cingulate gyrus (between normal and mild)
- focal atrophy of insular cortex on central operculum (between normal and mild)
- between mild and moderate bilateral parietal lobe atrophy
- focal atrophy of temporal lobe on fusiform gyrus (between normal and mild)
For the subcortical structures:
- no degenerative or atrophic changes noted in the hippocampus
- no signs of atrophy detected in the amygdala
- no evidence of atrophy or degeneration in the thalamus
- no observable atrophic alterations in the pallidum
- caudate maintains its normal morphology without atrophic features
- no degenerative or atrophic changes noted in the putamen
- no degenerative or atrophic changes noted in the basal forebrain
- no signs of atrophy detected in the accumbens
- ventral dc presents with a healthy appearance, free from atrophy | AD |
NIFD_1_S_0102_MR_T1_mprage_S3_DIS3D_br_raw_20170816161439198_36_S596667_I889712_dupl_1 | On a T1-weighted brain MRI of a 71-year-old male subject, we observed:
For the ventricles:
- between mild and moderate enlargement of the 3rd ventricle
- severe enlargement of the external csf
- 4th ventricle appears structurally intact, with no evidence of enlargement
- between mild and moderate left enlargement of the lateral ventricle
- inf. lateral ventricle maintains its normal volume without signs of enlargement
For the cerebral cortex:
- no evidence of atrophy or degeneration in the occipital lobe
- focal atrophy of parietal lobe on angular gyrus (between normal and mild)
- severe bilateral frontal lobe atrophy, with focal volume loss observed in the following subregions: frontal pole (moderate), gyrus rectus (between mild and moderate), middle frontal gyrus (severe), precentral gyrus (severe), sup. frontal gyrus (between mild and moderate) and supplementary motor cortex (moderate)
- atrophies of insular cortex on anterior insula (moderate) and frontal operculum (mild)
- the temporal lobe shows no structural abnormalities indicative of atrophy
- mild atrophy of the limbic cortex, more pronounced on the left, with focal volume loss observed in the following subregions: anterior cingulate gyrus (moderate) and middle cingulate gyrus (mild)
For the subcortical structures:
- severe bilateral caudate atrophy, more pronounced on the left
- between mild and moderate bilateral hippocampus atrophy
- mild atrophy of the basal forebrain, more pronounced on the left
- severe bilateral pallidum atrophy, more pronounced on the left
- severe bilateral putamen atrophy, more pronounced on the left
- severe bilateral ventral dc atrophy, more pronounced on the left
- severe bilateral thalamus atrophy, more pronounced on the left
- between normal and mild left atrophy of the accumbens
- between normal and mild atrophy of the amygdala | BV |
ADNI_022_S_4291_MR_MPRAGE_br_raw_20111130090916449_95_S131264_I269153 | On a T1-weighted brain MRI of a 76-year-old female subject, we observed:
For the ventricles:
- severe bilateral lateral ventricle enlargement
- no abnormal enlargement observed in the external csf
- 4th ventricle maintains its normal volume without signs of enlargement
- between moderate and severe enlargement of the 3rd ventricle
- inf. lateral ventricle is free from enlargement or excessive growth
For the cerebral cortex:
- focal atrophy of frontal lobe on sup. frontal gyrus (mild)
- atrophies of temporal lobe on planum temporale (between mild and moderate) and sup. temporal gyrus (mild)
- focal atrophy of parietal lobe on postcentral gyrus medial segment (between mild and moderate)
- focal atrophy of occipital lobe on occipital pole (between mild and moderate)
- focal atrophy of insular cortex on parietal operculum (between mild and moderate)
- focal atrophy of limbic cortex on posterior cingulate gyrus (mild)
For the subcortical structures:
- amygdala remains normal, with no signs of tissue loss
- thalamus presents with a healthy appearance, free from atrophy
- no signs of atrophy detected in the pallidum
- no signs of atrophy detected in the caudate
- mild right atrophy of the accumbens
- no signs of atrophy detected in the putamen
- no signs of atrophy detected in the basal forebrain
- ventral dc presents with a healthy appearance, free from atrophy
- hippocampus presents with a healthy appearance, free from atrophy | CN |
NIFD_1_S_0067_MR_t1_mprage_S6_DIS3D_br_raw_20111209120245536_154_S132398_I270856 | On a T1-weighted brain MRI of a 78-year-old male subject, we observed:
For the cerebral cortex:
- focal atrophy of limbic cortex on anterior cingulate gyrus (between normal and mild)
- between normal and mild atrophy of the insular cortex, more pronounced on the left, with focal volume loss observed in the following subregions: posterior insula (between normal and mild)
- focal atrophy of temporal lobe on middle temporal gyrus (between mild and moderate)
- atrophies of frontal lobe on orbital inf. frontal gyrus (mild), middle frontal gyrus (between normal and mild), medial orbital gyrus (between normal and mild), posterior orbital gyrus (moderate) and sup. frontal gyrus medial segment (between normal and mild)
- the parietal lobe shows no structural abnormalities indicative of atrophy
- focal atrophy of occipital lobe on calcarine cortex (between normal and mild)
For the ventricles:
- moderate enlargement of the 3rd ventricle
- no signs of enlargement detected in the 4th ventricle
- mild enlargement of the external csf
- mild enlargement of the lateral ventricle
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
For the subcortical structures:
- between mild and moderate atrophy of the putamen, more pronounced on the left
- between normal and mild left atrophy of the ventral dc
- no observable atrophic alterations in the basal forebrain
- between normal and mild atrophy of the hippocampus, more pronounced on the left
- between mild and moderate atrophy of the pallidum, more pronounced on the left
- moderate bilateral caudate atrophy, more pronounced on the left
- moderate left atrophy of the thalamus
- between moderate and severe bilateral accumbens atrophy
- severe bilateral amygdala atrophy, more pronounced on the left | PNFA |
NIFD_1_S_0112_MR_T1_mprage_S5_DIS3D_br_raw_20170816153347354_122_S596472_I889436_dupl_1 | On a T1-weighted brain MRI of a 78-year-old male subject, we observed:
For the ventricles:
- lateral ventricle remains within normal size parameters, with no enlargement detected
- no enlargement observed in the 3rd ventricle
- no observable enlargement or abnormal growth in the 4th ventricle
- no abnormal enlargement observed in the external csf
- inf. lateral ventricle appears structurally intact, with no evidence of enlargement
For the cerebral cortex:
- no degenerative or atrophic changes noted in the occipital lobe
- focal atrophy of frontal lobe on supplementary motor cortex (between normal and mild)
- temporal lobe presents with a healthy appearance, free from atrophy
- insular cortex appears structurally intact with no atrophic changes
- no signs of atrophy detected in the parietal lobe
- focal atrophy of limbic cortex on middle cingulate gyrus (moderate)
For the subcortical structures:
- severe bilateral putamen atrophy, more pronounced on the right
- no observable atrophic alterations in the ventral dc
- between moderate and severe bilateral accumbens atrophy
- hippocampus appears structurally intact with no atrophic changes
- no degenerative or atrophic changes noted in the basal forebrain
- thalamus presents with a healthy appearance, free from atrophy
- mild left atrophy of the amygdala
- mild atrophy of the pallidum, more pronounced on the right
- between normal and mild bilateral caudate atrophy | PNFA |
ADNI_153_S_4172_MR_MPRAGE_br_raw_20110817113413375_135_S119196_I251187_dupl_4 | On a T1-weighted brain MRI of a 76-year-old male subject, we observed:
For the subcortical structures:
- severe bilateral putamen atrophy, more pronounced on the left
- the thalamus shows no structural abnormalities indicative of atrophy
- between moderate and severe bilateral caudate atrophy, more pronounced on the left
- mild left atrophy of the pallidum
- mild left atrophy of the hippocampus
- ventral dc appears structurally intact with no atrophic changes
- between mild and moderate atrophy of the accumbens, more pronounced on the left
- basal forebrain maintains its normal morphology without atrophic features
- mild left atrophy of the amygdala
For the ventricles:
- 3rd ventricle is free from enlargement or excessive growth
- 4th ventricle remains within normal size parameters, with no enlargement detected
- the inf. lateral ventricle shows no structural abnormalities indicative of enlargement
- external csf remains within normal size parameters, with no enlargement detected
- between normal and mild left enlargement of the lateral ventricle
For the cerebral cortex:
- limbic cortex appears structurally intact with no atrophic changes
- moderate bilateral insular cortex atrophy, with focal volume loss observed in the following subregions: anterior insula (between normal and mild) and parietal operculum (moderate)
- focal atrophy of temporal lobe on planum temporale (mild)
- mild atrophy of the parietal lobe, with focal volume loss observed in the following subregions: postcentral gyrus (between normal and mild) and supramarginal gyrus (between mild and moderate)
- atrophies of frontal lobe on frontal pole (between normal and mild) and middle frontal gyrus (mild)
- occipital lobe presents with a healthy appearance, free from atrophy | AD |
NIFD_2_S_0027_MR_MT1__GradWarp__N3m_Br_20130103113648528_S177998_I353170_dupl_1 | On a T1-weighted brain MRI of a 58-year-old female subject, we observed:
For the subcortical structures:
- basal forebrain appears structurally intact with no atrophic changes
- the thalamus shows no structural abnormalities indicative of atrophy
- between mild and moderate bilateral putamen atrophy
- between mild and moderate bilateral pallidum atrophy
- the ventral dc shows no structural abnormalities indicative of atrophy
- caudate remains normal, with no signs of tissue loss
- severe bilateral hippocampus atrophy, more pronounced on the left
- between mild and moderate atrophy of the accumbens, more pronounced on the right
- severe bilateral amygdala atrophy
For the ventricles:
- between normal and mild enlargement of the inf. lateral ventricle, more pronounced on the left
- lateral ventricle appears structurally intact, with no evidence of enlargement
- mild enlargement of the 4th ventricle
- no abnormal enlargement observed in the 3rd ventricle
- severe enlargement of the external csf
For the cerebral cortex:
- focal atrophy of occipital lobe on cuneus (between normal and mild)
- severe bilateral temporal lobe atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: fusiform gyrus (moderate), middle temporal gyrus (moderate), sup. temporal gyrus (between normal and mild) and temporal pole (severe)
- parietal lobe appears structurally intact with no atrophic changes
- atrophies of frontal lobe on lateral orbital gyrus (moderate) and opercular inf. frontal gyrus (between normal and mild)
- between moderate and severe bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: entorhinal area (severe) and parahippocampal gyrus (severe)
- moderate bilateral insular cortex atrophy, with focal volume loss observed in the following subregions: anterior insula (severe) and posterior insula (between normal and mild) | BV |
NIFD_1_S_0072_MR_T1_mprage_S3_DIS3D_br_raw_20170816175300325_153_S597008_I890174_dupl_5 | On a T1-weighted brain MRI of a 69-year-old male subject, we observed:
For the cerebral cortex:
- atrophies of limbic cortex on entorhinal area (severe) and parahippocampal gyrus (severe)
- the occipital lobe shows no structural abnormalities indicative of atrophy
- severe bilateral insular cortex atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (moderate) and parietal operculum (between mild and moderate)
- atrophies of frontal lobe on posterior orbital gyrus (moderate) and sup. frontal gyrus medial segment (mild)
- severe bilateral temporal lobe atrophy, more pronounced on the left, with focal volume loss observed in the following subregions: fusiform gyrus (between moderate and severe), planum temporale (between moderate and severe), inf. temporal gyrus (severe), middle temporal gyrus (severe), sup. temporal gyrus (between mild and moderate) and temporal pole (severe)
- parietal lobe appears structurally intact with no atrophic changes
For the ventricles:
- no observable enlargement or abnormal growth in the 3rd ventricle
- no observable enlargement or abnormal growth in the 4th ventricle
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
- no observable enlargement or abnormal growth in the lateral ventricle
- between moderate and severe enlargement of the external csf
For the subcortical structures:
- moderate atrophy of the putamen, more pronounced on the left
- no observable atrophic alterations in the basal forebrain
- severe bilateral accumbens atrophy, more pronounced on the left
- caudate remains normal, with no signs of tissue loss
- ventral dc remains normal, with no signs of tissue loss
- between normal and mild atrophy of the thalamus, more pronounced on the left
- between normal and mild atrophy of the pallidum, more pronounced on the left
- severe bilateral hippocampus atrophy, more pronounced on the left
- severe bilateral amygdala atrophy, more pronounced on the left | SV |
NIFD_1_S_0053_MR_T1_mprage_S3_DIS3D_br_raw_20170817095339381_67_S597254_I890544_dupl_5 | On a T1-weighted brain MRI of a 69-year-old male subject, we observed:
For the cerebral cortex:
- no observable atrophic alterations in the occipital lobe
- parietal lobe remains normal, with no signs of tissue loss
- severe bilateral limbic cortex atrophy, with focal volume loss observed in the following subregions: entorhinal area (between moderate and severe), anterior cingulate gyrus (severe) and parahippocampal gyrus (between normal and mild)
- severe bilateral insular cortex atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: anterior insula (severe), posterior insula (between moderate and severe) and parietal operculum (moderate)
- severe bilateral temporal lobe atrophy, more pronounced on the right, with focal volume loss observed in the following subregions: fusiform gyrus (severe), planum temporale (moderate), inf. temporal gyrus (severe), sup. temporal gyrus (between normal and mild) and temporal pole (severe)
- focal atrophy of frontal lobe on subcallosal area (mild)
For the ventricles:
- between normal and mild enlargement of the lateral ventricle, more pronounced on the left
- severe bilateral inf. lateral ventricle enlargement, more pronounced on the left
- mild enlargement of the external csf
- no pathological changes consistent with enlargement noted in the 4th ventricle
- the 3rd ventricle shows no structural abnormalities indicative of enlargement
For the subcortical structures:
- severe bilateral hippocampus atrophy
- no pathological changes consistent with atrophy detected in the ventral dc
- no degenerative or atrophic changes noted in the basal forebrain
- no degenerative or atrophic changes noted in the caudate
- moderate bilateral putamen atrophy, more pronounced on the left
- severe bilateral accumbens atrophy, more pronounced on the right
- thalamus maintains its normal morphology without atrophic features
- no pathological changes consistent with atrophy detected in the pallidum
- severe bilateral amygdala atrophy | SV |
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