id
stringlengths 15
15
| document_id
stringlengths 11
11
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
NCT02654912_exc
|
NCT02654912
|
[
{
"id": "NCT02654912_exc_text",
"type": "exclusion",
"text": [
"contraindications from manufacturer for medications including currently taking haloperidol, artane, Phenergan (Promethazine), chlorpromazine, erythromycin, Azithromycin, clarithromycin, Ketoconazole, fluconazole, mefloquine (as prophylaxis), lumefantrine (in Coartem), quinine, Septrin\nanyone seriously ill\ncurrently taking antimalarial medicines\nallergy to artemisinin drugs\npregnant women in first trimester\nchildren under 3 months of age\nreported heart condition\n"
],
"offsets": [
[
0,
466
]
]
}
] |
[
{
"id": "NCT02654912_exc_T1",
"type": "Condition",
"text": [
"contraindications"
],
"offsets": [
[
0,
17
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T2",
"type": "Drug",
"text": [
"haloperidol"
],
"offsets": [
[
79,
90
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T3",
"type": "Drug",
"text": [
"Phenergan"
],
"offsets": [
[
100,
109
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T4",
"type": "Drug",
"text": [
"Promethazine"
],
"offsets": [
[
111,
123
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T5",
"type": "Drug",
"text": [
"artane"
],
"offsets": [
[
92,
98
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T6",
"type": "Drug",
"text": [
"chlorpromazine"
],
"offsets": [
[
126,
140
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T7",
"type": "Drug",
"text": [
"erythromycin"
],
"offsets": [
[
142,
154
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T8",
"type": "Drug",
"text": [
"Azithromycin"
],
"offsets": [
[
156,
168
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T9",
"type": "Drug",
"text": [
"clarithromycin"
],
"offsets": [
[
170,
184
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T10",
"type": "Drug",
"text": [
"Ketoconazole"
],
"offsets": [
[
186,
198
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T11",
"type": "Drug",
"text": [
"fluconazole"
],
"offsets": [
[
200,
211
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T12",
"type": "Drug",
"text": [
"mefloquine"
],
"offsets": [
[
213,
223
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T13",
"type": "Drug",
"text": [
"lumefantrine"
],
"offsets": [
[
242,
254
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T14",
"type": "Drug",
"text": [
"Coartem"
],
"offsets": [
[
259,
266
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T15",
"type": "Drug",
"text": [
"quinine"
],
"offsets": [
[
269,
276
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T16",
"type": "Drug",
"text": [
"Septrin"
],
"offsets": [
[
278,
285
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T17",
"type": "Scope",
"text": [
"haloperidol, artane, Phenergan (Promethazine), chlorpromazine, erythromycin, Azithromycin, clarithromycin, Ketoconazole, fluconazole, mefloquine (as prophylaxis), lumefantrine (in Coartem), quinine, Septrin"
],
"offsets": [
[
79,
285
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T18",
"type": "Condition",
"text": [
"seriously ill"
],
"offsets": [
[
293,
306
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T19",
"type": "Drug",
"text": [
"antimalarial medicines"
],
"offsets": [
[
324,
346
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T20",
"type": "Drug",
"text": [
"artemisinin drugs"
],
"offsets": [
[
358,
375
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T21",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
347,
354
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T22",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
376,
384
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T23",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
385,
390
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T24",
"type": "Condition",
"text": [
"first trimester"
],
"offsets": [
[
394,
409
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T26",
"type": "Qualifier",
"text": [
"first trimester"
],
"offsets": [
[
394,
409
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T25",
"type": "Person",
"text": [
"children"
],
"offsets": [
[
410,
418
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T27",
"type": "Value",
"text": [
"under 3 months"
],
"offsets": [
[
419,
433
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T28",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
437,
440
]
],
"normalized": []
},
{
"id": "NCT02654912_exc_T29",
"type": "Condition",
"text": [
"heart condition"
],
"offsets": [
[
450,
465
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02654912_exc_R1",
"type": "AND",
"arg1_id": "NCT02654912_exc_T13",
"arg2_id": "NCT02654912_exc_T14",
"normalized": []
},
{
"id": "NCT02654912_exc_R2",
"type": "Subsumes",
"arg1_id": "NCT02654912_exc_T3",
"arg2_id": "NCT02654912_exc_T4",
"normalized": []
},
{
"id": "NCT02654912_exc_R3",
"type": "Has_scope",
"arg1_id": "NCT02654912_exc_T1",
"arg2_id": "NCT02654912_exc_T17",
"normalized": []
},
{
"id": "NCT02654912_exc_R4",
"type": "AND",
"arg1_id": "NCT02654912_exc_T21",
"arg2_id": "NCT02654912_exc_T20",
"normalized": []
},
{
"id": "NCT02654912_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02654912_exc_T22",
"arg2_id": "NCT02654912_exc_T26",
"normalized": []
},
{
"id": "NCT02654912_exc_R6",
"type": "Has_value",
"arg1_id": "NCT02654912_exc_T28",
"arg2_id": "NCT02654912_exc_T27",
"normalized": []
}
] |
NCT02654912_inc
|
NCT02654912
|
[
{
"id": "NCT02654912_inc_text",
"type": "inclusion",
"text": [
"anyone not excluded and consenting\n"
],
"offsets": [
[
0,
35
]
]
}
] |
[] |
[] |
[] |
[] |
NCT02656394_exc
|
NCT02656394
|
[
{
"id": "NCT02656394_exc_text",
"type": "exclusion",
"text": [
"1. Comorbidity with other severe or chronic eye conditions that in the judgment of the investigator will interfere with study assessments, such as corneal opacities and scars, dystrophies, epithelial scarring, infections, blood clots, etc. \n2. Best corrected visual acuity (BCVA) at baseline <20/200. \n3. Has a condition or history that, in the opinion of the investigator, may interfere significantly with the subject's participation in the study. \n4. A woman who is pregnant, nursing an infant, or planning a pregnancy. \n5. Has a known adverse reaction and/or sensitivity to the study drug or its components. \n6. Routine use (more than twice a week) of a chlorinated swimming pool. \n7. Unwilling or unable to cease using the following medications during the study period: Topical ocular cyclosporine (e.g. Restasis®), anti-histamines, antipsychotics, or eye gels. \n8. Currently enrolled in an investigational drug or device study or have used an investigational drug or device within 30 days prior to Visit 1. \n \n"
],
"offsets": [
[
0,
1024
]
]
}
] |
[
{
"id": "NCT02656394_exc_T12",
"type": "Condition",
"text": [
"corneal opacities"
],
"offsets": [
[
147,
164
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T13",
"type": "Condition",
"text": [
"corneal",
"scars"
],
"offsets": [
[
147,
154
],
[
169,
174
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T14",
"type": "Condition",
"text": [
"dystrophies"
],
"offsets": [
[
176,
187
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T15",
"type": "Condition",
"text": [
"epithelial scarring"
],
"offsets": [
[
189,
208
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T16",
"type": "Condition",
"text": [
"infections"
],
"offsets": [
[
210,
220
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T17",
"type": "Condition",
"text": [
"blood clots"
],
"offsets": [
[
222,
233
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T18",
"type": "Condition",
"text": [
"eye conditions"
],
"offsets": [
[
44,
58
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T19",
"type": "Qualifier",
"text": [
"will interfere with study assessments"
],
"offsets": [
[
100,
137
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T20",
"type": "Scope",
"text": [
"corneal opacities and scars, dystrophies, epithelial scarring, infections, blood clots"
],
"offsets": [
[
147,
233
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T21",
"type": "Measurement",
"text": [
"Best corrected visual acuity (BCVA)"
],
"offsets": [
[
244,
279
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T22",
"type": "Value",
"text": [
"<20/200"
],
"offsets": [
[
292,
299
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T23",
"type": "Temporal",
"text": [
"at baseline"
],
"offsets": [
[
280,
291
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T24",
"type": "Reference_point",
"text": [
"baseline"
],
"offsets": [
[
283,
291
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T25",
"type": "Person",
"text": [
"woman"
],
"offsets": [
[
455,
460
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T26",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
468,
476
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T30",
"type": "Condition",
"text": [
"nursing"
],
"offsets": [
[
478,
485
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T32",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
511,
520
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T33",
"type": "Condition",
"text": [
"adverse reaction",
"to the study drug or its components"
],
"offsets": [
[
538,
554
],
[
574,
609
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T34",
"type": "Condition",
"text": [
"sensitivity to the study drug or its components"
],
"offsets": [
[
562,
609
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T35",
"type": "Multiplier",
"text": [
"more than twice a week"
],
"offsets": [
[
628,
650
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T36",
"type": "Multiplier",
"text": [
"Routine use"
],
"offsets": [
[
615,
626
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T37",
"type": "Observation",
"text": [
"chlorinated swimming pool"
],
"offsets": [
[
657,
682
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T41",
"type": "Drug",
"text": [
"Topical ocular cyclosporine"
],
"offsets": [
[
774,
801
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T42",
"type": "Drug",
"text": [
"Restasis®"
],
"offsets": [
[
808,
817
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T43",
"type": "Drug",
"text": [
"anti-histamines"
],
"offsets": [
[
820,
835
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T44",
"type": "Drug",
"text": [
"antipsychotics"
],
"offsets": [
[
837,
851
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T45",
"type": "Drug",
"text": [
"eye gels"
],
"offsets": [
[
856,
864
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T46",
"type": "Temporal",
"text": [
"during the study period"
],
"offsets": [
[
749,
772
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T47",
"type": "Reference_point",
"text": [
"study period"
],
"offsets": [
[
760,
772
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T48",
"type": "Scope",
"text": [
"Topical ocular cyclosporine (e.g. Restasis®), anti-histamines, antipsychotics, or eye gels"
],
"offsets": [
[
774,
864
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T49",
"type": "Drug",
"text": [
"investigational drug"
],
"offsets": [
[
895,
915
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T51",
"type": "Device",
"text": [
"investigational",
"device"
],
"offsets": [
[
895,
910
],
[
919,
925
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T53",
"type": "Drug",
"text": [
"investigational drug"
],
"offsets": [
[
948,
968
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T55",
"type": "Temporal",
"text": [
"within 30 days prior to Visit 1"
],
"offsets": [
[
979,
1010
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T56",
"type": "Reference_point",
"text": [
"Visit 1"
],
"offsets": [
[
1003,
1010
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T57",
"type": "Device",
"text": [
"investigational",
"device"
],
"offsets": [
[
948,
963
],
[
972,
978
]
],
"normalized": []
},
{
"id": "NCT02656394_exc_T58",
"type": "Scope",
"text": [
"investigational drug or device study or have used an investigational drug or device"
],
"offsets": [
[
895,
978
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02656394_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02656394_exc_T18",
"arg2_id": "NCT02656394_exc_T19",
"normalized": []
},
{
"id": "NCT02656394_exc_R2",
"type": "Has_scope",
"arg1_id": "NCT02656394_exc_T18",
"arg2_id": "NCT02656394_exc_T20",
"normalized": []
},
{
"id": "NCT02656394_exc_R3",
"type": "Has_index",
"arg1_id": "NCT02656394_exc_T23",
"arg2_id": "NCT02656394_exc_T24",
"normalized": []
},
{
"id": "NCT02656394_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02656394_exc_T21",
"arg2_id": "NCT02656394_exc_T23",
"normalized": []
},
{
"id": "NCT02656394_exc_R5",
"type": "Has_value",
"arg1_id": "NCT02656394_exc_T21",
"arg2_id": "NCT02656394_exc_T22",
"normalized": []
},
{
"id": "NCT02656394_exc_R6",
"type": "Subsumes",
"arg1_id": "NCT02656394_exc_T36",
"arg2_id": "NCT02656394_exc_T35",
"normalized": []
},
{
"id": "NCT02656394_exc_R7",
"type": "Has_multiplier",
"arg1_id": "NCT02656394_exc_T37",
"arg2_id": "NCT02656394_exc_T36",
"normalized": []
},
{
"id": "NCT02656394_exc_R8",
"type": "Subsumes",
"arg1_id": "NCT02656394_exc_T41",
"arg2_id": "NCT02656394_exc_T42",
"normalized": []
},
{
"id": "NCT02656394_exc_R9",
"type": "Has_index",
"arg1_id": "NCT02656394_exc_T46",
"arg2_id": "NCT02656394_exc_T47",
"normalized": []
},
{
"id": "NCT02656394_exc_R10",
"type": "Has_temporal",
"arg1_id": "NCT02656394_exc_T48",
"arg2_id": "NCT02656394_exc_T46",
"normalized": []
},
{
"id": "NCT02656394_exc_R11",
"type": "Has_index",
"arg1_id": "NCT02656394_exc_T55",
"arg2_id": "NCT02656394_exc_T56",
"normalized": []
},
{
"id": "NCT02656394_exc_R12",
"type": "Has_temporal",
"arg1_id": "NCT02656394_exc_T58",
"arg2_id": "NCT02656394_exc_T55",
"normalized": []
}
] |
NCT02656394_inc
|
NCT02656394
|
[
{
"id": "NCT02656394_inc_text",
"type": "inclusion",
"text": [
"1. Male or female of any race, at least 18 years of age at Visit 1 Screening. \n2. Has provided verbal and written informed consent. \n3. Be able and willing to follow instructions, including participation in all study assessments and visits. \n4. Currently being treated for glaucoma using at least two medications, and be willing to continue on the same regime. \n5. Suffers from at least two of the symptoms in the GLIA™ Glaucoma Medication Ocular Side Effect Symptoms Questionnaire at a severity of 2 (moderate) or more. \n6. If a woman of childbearing potential, have a negative urine pregnancy test at Visit 1 and be using an adequate method of birth control throughout the study period. \n"
],
"offsets": [
[
0,
690
]
]
}
] |
[
{
"id": "NCT02656394_inc_T7",
"type": "Person",
"text": [
"Male"
],
"offsets": [
[
3,
7
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T8",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
11,
17
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T9",
"type": "Value",
"text": [
"at least 18 years"
],
"offsets": [
[
31,
48
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T10",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
52,
55
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T11",
"type": "Temporal",
"text": [
"at Visit 1 Screening"
],
"offsets": [
[
56,
76
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T12",
"type": "Reference_point",
"text": [
"Visit 1 Screening"
],
"offsets": [
[
59,
76
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T17",
"type": "Condition",
"text": [
"glaucoma"
],
"offsets": [
[
273,
281
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T18",
"type": "Procedure",
"text": [
"treated"
],
"offsets": [
[
261,
268
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T19",
"type": "Temporal",
"text": [
"Currently"
],
"offsets": [
[
245,
254
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T20",
"type": "Multiplier",
"text": [
"at least two"
],
"offsets": [
[
288,
300
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T21",
"type": "Drug",
"text": [
"medications"
],
"offsets": [
[
301,
312
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T24",
"type": "Multiplier",
"text": [
"at least two"
],
"offsets": [
[
378,
390
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T25",
"type": "Condition",
"text": [
"symptoms"
],
"offsets": [
[
398,
406
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T26",
"type": "Measurement",
"text": [
"GLIA™ Glaucoma Medication Ocular Side Effect Symptoms Questionnaire"
],
"offsets": [
[
414,
481
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T27",
"type": "Value",
"text": [
"severity of 2",
"or more"
],
"offsets": [
[
487,
500
],
[
512,
519
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T28",
"type": "Value",
"text": [
"moderate"
],
"offsets": [
[
502,
510
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T29",
"type": "Person",
"text": [
"woman"
],
"offsets": [
[
530,
535
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T30",
"type": "Condition",
"text": [
"childbearing potential"
],
"offsets": [
[
539,
561
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T31",
"type": "Measurement",
"text": [
"urine pregnancy test"
],
"offsets": [
[
579,
599
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T32",
"type": "Value",
"text": [
"negative"
],
"offsets": [
[
570,
578
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T33",
"type": "Temporal",
"text": [
"at Visit 1"
],
"offsets": [
[
600,
610
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T34",
"type": "Reference_point",
"text": [
"Visit 1"
],
"offsets": [
[
603,
610
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T35",
"type": "Device",
"text": [
"method of birth control"
],
"offsets": [
[
636,
659
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T36",
"type": "Qualifier",
"text": [
"adequate"
],
"offsets": [
[
627,
635
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T38",
"type": "Temporal",
"text": [
"throughout the study period"
],
"offsets": [
[
660,
687
]
],
"normalized": []
},
{
"id": "NCT02656394_inc_T39",
"type": "Reference_point",
"text": [
"study period"
],
"offsets": [
[
675,
687
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02656394_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02656394_inc_T10",
"arg2_id": "NCT02656394_inc_T9",
"normalized": []
},
{
"id": "NCT02656394_inc_R2",
"type": "Has_index",
"arg1_id": "NCT02656394_inc_T11",
"arg2_id": "NCT02656394_inc_T12",
"normalized": []
},
{
"id": "NCT02656394_inc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02656394_inc_T10",
"arg2_id": "NCT02656394_inc_T11",
"normalized": []
},
{
"id": "NCT02656394_inc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02656394_inc_T18",
"arg2_id": "NCT02656394_inc_T19",
"normalized": []
},
{
"id": "NCT02656394_inc_R5",
"type": "AND",
"arg1_id": "NCT02656394_inc_T18",
"arg2_id": "NCT02656394_inc_T17",
"normalized": []
},
{
"id": "NCT02656394_inc_R6",
"type": "Has_multiplier",
"arg1_id": "NCT02656394_inc_T21",
"arg2_id": "NCT02656394_inc_T20",
"normalized": []
},
{
"id": "NCT02656394_inc_R7",
"type": "AND",
"arg1_id": "NCT02656394_inc_T18",
"arg2_id": "NCT02656394_inc_T21",
"normalized": []
},
{
"id": "NCT02656394_inc_R8",
"type": "Subsumes",
"arg1_id": "NCT02656394_inc_T27",
"arg2_id": "NCT02656394_inc_T28",
"normalized": []
},
{
"id": "NCT02656394_inc_R9",
"type": "Has_value",
"arg1_id": "NCT02656394_inc_T26",
"arg2_id": "NCT02656394_inc_T27",
"normalized": []
},
{
"id": "NCT02656394_inc_R10",
"type": "Has_multiplier",
"arg1_id": "NCT02656394_inc_T25",
"arg2_id": "NCT02656394_inc_T24",
"normalized": []
},
{
"id": "NCT02656394_inc_R11",
"type": "AND",
"arg1_id": "NCT02656394_inc_T25",
"arg2_id": "NCT02656394_inc_T26",
"normalized": []
},
{
"id": "NCT02656394_inc_R12",
"type": "AND",
"arg1_id": "NCT02656394_inc_T29",
"arg2_id": "NCT02656394_inc_T30",
"normalized": []
},
{
"id": "NCT02656394_inc_R13",
"type": "Has_value",
"arg1_id": "NCT02656394_inc_T31",
"arg2_id": "NCT02656394_inc_T32",
"normalized": []
},
{
"id": "NCT02656394_inc_R14",
"type": "Has_index",
"arg1_id": "NCT02656394_inc_T33",
"arg2_id": "NCT02656394_inc_T34",
"normalized": []
},
{
"id": "NCT02656394_inc_R15",
"type": "Has_temporal",
"arg1_id": "NCT02656394_inc_T31",
"arg2_id": "NCT02656394_inc_T33",
"normalized": []
},
{
"id": "NCT02656394_inc_R16",
"type": "Has_qualifier",
"arg1_id": "NCT02656394_inc_T35",
"arg2_id": "NCT02656394_inc_T36",
"normalized": []
},
{
"id": "NCT02656394_inc_R17",
"type": "Has_index",
"arg1_id": "NCT02656394_inc_T38",
"arg2_id": "NCT02656394_inc_T39",
"normalized": []
},
{
"id": "NCT02656394_inc_R18",
"type": "Has_temporal",
"arg1_id": "NCT02656394_inc_T35",
"arg2_id": "NCT02656394_inc_T38",
"normalized": []
}
] |
NCT02664558_exc
|
NCT02664558
|
[
{
"id": "NCT02664558_exc_text",
"type": "exclusion",
"text": [
"Exclusions Related to Cardiovascular Disease \n1. History of uncontrolled hypertension \n2. Persistent hypotension at Screening. \n3. Evidence or history of left-sided heart disease and/or clinically significant cardiac disease in which pulmonary hypertension is more likely WHO Group 2. \n4. Acute decompensated heart failure within 1 month of Screening. \n5. Recent initiation (<8 weeks from Screening) or planned initiation of cardiopulmonary rehabilitation exercise program. \nExclusions Related to Pulmonary Disease \n6. Newly diagnosed with PAH and not on PAH-specific therapy. \n7. Pulmonary hypertension due to: \n1. Uncorrected congenital systemic-to-pulmonary shunt. \n2. Pulmonary veno-occlusive disease and/or pulmonary capillary hemangiomatosis \n3. Persistent pulmonary hypertension of the newborn \n4. WHO clinical classification Groups 2-5 \n8. Evidence of significant airway and/or parenchymal lung disease. \n9. Chronic infection related to tuberculosis or fungal or mycobacterial disease. \nExclusions Based on Other Medical Conditions \n10. Chronic infections including, but not limited to tuberculosis (TB), hepatitis B virus (HBV) or hepatitis C virus (HCV). \n11. History of portal hypertension or chronic liver disease, including positive serology for infection with HCV and/or HBV. \n12. Evidence of active infection requiring intravenous or oral antibiotics within 4 weeks of Screening. \n13. Body mass index ≥35.0 at Screening. \n14. History of obstructive sleep apnea. \n15. History of malignancy within the last 5 years, except nonmelanoma skin cancer and cervical carcinoma in situ treated with curative intent. \n16. Neuropsychiatric disorders/symptoms or psychological conditions. \n17. Pregnancy or breast-feeding \n18. Prior treatment with B cell or lymphocyte-depleting agents (eg, rituximab, Campath) \nExclusions Based on Concomitant Medication Use \n19. Concurrent regular use of another leukotriene pathway inhibitor, including over-the-counter medications or herbal remedies. \nExclusions Based on Laboratory Values \n20. Significant/chronic renal insufficiency. \n21. Transaminases (alanine transaminase, aspartate transaminase) levels >3 × upper limit of normal (ULN) and/or bilirubin level >2 × ULN. \n22. Absolute neutrophil count <1500 mm3. \n23. Hemoglobin concentration <9 g/dL at Screening. \n24. Hepatic dysfunction as defined by Child-Pugh Class B or C \n \n"
],
"offsets": [
[
0,
2383
]
]
}
] |
[
{
"id": "NCT02664558_exc_T34",
"type": "Condition",
"text": [
"hypertension"
],
"offsets": [
[
73,
85
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T35",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
60,
72
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T36",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
49,
56
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T37",
"type": "Condition",
"text": [
"Persistent hypotension"
],
"offsets": [
[
90,
112
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T38",
"type": "Temporal",
"text": [
"at Screening"
],
"offsets": [
[
113,
125
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T39",
"type": "Reference_point",
"text": [
"Screening"
],
"offsets": [
[
116,
125
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T40",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
143,
150
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T41",
"type": "Condition",
"text": [
"left-sided heart disease"
],
"offsets": [
[
154,
178
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T42",
"type": "Condition",
"text": [
"cardiac disease"
],
"offsets": [
[
209,
224
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T43",
"type": "Qualifier",
"text": [
"clinically significant"
],
"offsets": [
[
186,
208
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T46",
"type": "Condition",
"text": [
"pulmonary hypertension"
],
"offsets": [
[
234,
256
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T47",
"type": "Measurement",
"text": [
"WHO Group"
],
"offsets": [
[
272,
281
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T48",
"type": "Value",
"text": [
"2"
],
"offsets": [
[
282,
283
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T49",
"type": "Scope",
"text": [
"left-sided heart disease and/or clinically significant cardiac disease in which pulmonary hypertension is more likely WHO Group 2"
],
"offsets": [
[
154,
283
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T50",
"type": "Condition",
"text": [
"heart failure"
],
"offsets": [
[
309,
322
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T51",
"type": "Qualifier",
"text": [
"decompensated"
],
"offsets": [
[
295,
308
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T52",
"type": "Qualifier",
"text": [
"Acute"
],
"offsets": [
[
289,
294
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T53",
"type": "Temporal",
"text": [
"within 1 month of Screening"
],
"offsets": [
[
323,
350
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T54",
"type": "Reference_point",
"text": [
"Screening"
],
"offsets": [
[
341,
350
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T55",
"type": "Temporal",
"text": [
"<8 weeks from Screening"
],
"offsets": [
[
375,
398
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T56",
"type": "Temporal",
"text": [
"Recent"
],
"offsets": [
[
356,
362
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T57",
"type": "Reference_point",
"text": [
"Screening"
],
"offsets": [
[
389,
398
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T58",
"type": "Qualifier",
"text": [
"planned"
],
"offsets": [
[
403,
410
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T60",
"type": "Procedure",
"text": [
"cardiopulmonary rehabilitation exercise program"
],
"offsets": [
[
425,
472
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T61",
"type": "Scope",
"text": [
"Recent initiation (<8 weeks from Screening) or planned"
],
"offsets": [
[
356,
410
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T62",
"type": "Condition",
"text": [
"PAH"
],
"offsets": [
[
540,
543
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T63",
"type": "Procedure",
"text": [
"PAH-specific therapy"
],
"offsets": [
[
555,
575
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T64",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
548,
551
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T65",
"type": "Temporal",
"text": [
"Newly diagnosed"
],
"offsets": [
[
519,
534
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T67",
"type": "Condition",
"text": [
"congenital systemic-to-pulmonary shunt"
],
"offsets": [
[
628,
666
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T68",
"type": "Qualifier",
"text": [
"Uncorrected"
],
"offsets": [
[
616,
627
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T69",
"type": "Condition",
"text": [
"Pulmonary veno-occlusive disease"
],
"offsets": [
[
672,
704
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T71",
"type": "Condition",
"text": [
"pulmonary capillary hemangiomatosis"
],
"offsets": [
[
712,
747
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T72",
"type": "Condition",
"text": [
"pulmonary hypertension of the newborn"
],
"offsets": [
[
763,
800
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T73",
"type": "Qualifier",
"text": [
"Persistent"
],
"offsets": [
[
752,
762
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T74",
"type": "Measurement",
"text": [
"WHO clinical classification"
],
"offsets": [
[
805,
832
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T75",
"type": "Value",
"text": [
"Groups 2-5"
],
"offsets": [
[
833,
843
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T76",
"type": "Condition",
"text": [
"airway",
"disease"
],
"offsets": [
[
872,
878
],
[
903,
910
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T77",
"type": "Condition",
"text": [
"parenchymal lung disease"
],
"offsets": [
[
886,
910
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T78",
"type": "Qualifier",
"text": [
"significant"
],
"offsets": [
[
860,
871
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T79",
"type": "Scope",
"text": [
"airway and/or parenchymal lung disease"
],
"offsets": [
[
872,
910
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T82",
"type": "Condition",
"text": [
"tuberculosis"
],
"offsets": [
[
945,
957
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T83",
"type": "Condition",
"text": [
"fungal",
"disease"
],
"offsets": [
[
961,
967
],
[
985,
992
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T84",
"type": "Condition",
"text": [
"mycobacterial disease"
],
"offsets": [
[
971,
992
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T85",
"type": "Multiplier",
"text": [
"Chronic"
],
"offsets": [
[
916,
923
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T86",
"type": "Condition",
"text": [
"infection"
],
"offsets": [
[
924,
933
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T87",
"type": "Scope",
"text": [
"tuberculosis or fungal or mycobacterial disease"
],
"offsets": [
[
945,
992
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T88",
"type": "Observation",
"text": [
"related to"
],
"offsets": [
[
934,
944
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T89",
"type": "Condition",
"text": [
"tuberculosis (TB)"
],
"offsets": [
[
1094,
1111
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T90",
"type": "Condition",
"text": [
"hepatitis B virus (HBV)"
],
"offsets": [
[
1113,
1136
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T91",
"type": "Condition",
"text": [
"hepatitis C virus (HCV)"
],
"offsets": [
[
1140,
1163
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T92",
"type": "Condition",
"text": [
"infections"
],
"offsets": [
[
1053,
1063
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T93",
"type": "Multiplier",
"text": [
"Chronic"
],
"offsets": [
[
1045,
1052
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T94",
"type": "Scope",
"text": [
"tuberculosis (TB), hepatitis B virus (HBV) or hepatitis C virus (HCV)"
],
"offsets": [
[
1094,
1163
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T95",
"type": "Condition",
"text": [
"portal hypertension"
],
"offsets": [
[
1181,
1200
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T96",
"type": "Condition",
"text": [
"chronic liver disease"
],
"offsets": [
[
1204,
1225
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T97",
"type": "Measurement",
"text": [
"serology for infection with HCV"
],
"offsets": [
[
1246,
1277
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T98",
"type": "Measurement",
"text": [
"serology for infection",
"HBV"
],
"offsets": [
[
1246,
1268
],
[
1285,
1288
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T99",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
1237,
1245
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T100",
"type": "Scope",
"text": [
"positive serology for infection with HCV and/or HBV"
],
"offsets": [
[
1237,
1288
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T101",
"type": "Condition",
"text": [
"infection requiring",
"antibiotics"
],
"offsets": [
[
1314,
1333
],
[
1354,
1365
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T104",
"type": "Temporal",
"text": [
"within 4 weeks of Screening"
],
"offsets": [
[
1366,
1393
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T105",
"type": "Reference_point",
"text": [
"Screening"
],
"offsets": [
[
1384,
1393
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T106",
"type": "Measurement",
"text": [
"Body mass index"
],
"offsets": [
[
1400,
1415
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T107",
"type": "Value",
"text": [
"≥35.0"
],
"offsets": [
[
1416,
1421
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T108",
"type": "Temporal",
"text": [
"at Screening"
],
"offsets": [
[
1422,
1434
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T109",
"type": "Reference_point",
"text": [
"Screening"
],
"offsets": [
[
1425,
1434
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T110",
"type": "Condition",
"text": [
"obstructive sleep apnea"
],
"offsets": [
[
1452,
1475
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T111",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
1441,
1448
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T112",
"type": "Condition",
"text": [
"malignancy"
],
"offsets": [
[
1493,
1503
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T114",
"type": "Temporal",
"text": [
"within the last 5 years"
],
"offsets": [
[
1504,
1527
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T115",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
1482,
1489
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T116",
"type": "Condition",
"text": [
"nonmelanoma skin cancer"
],
"offsets": [
[
1536,
1559
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T117",
"type": "Negation",
"text": [
"except"
],
"offsets": [
[
1529,
1535
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T118",
"type": "Condition",
"text": [
"cervical carcinoma in situ"
],
"offsets": [
[
1564,
1590
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T119",
"type": "Procedure",
"text": [
"treated"
],
"offsets": [
[
1591,
1598
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T120",
"type": "Qualifier",
"text": [
"curative intent"
],
"offsets": [
[
1604,
1619
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T121",
"type": "Condition",
"text": [
"Neuropsychiatric disorders"
],
"offsets": [
[
1626,
1652
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T123",
"type": "Condition",
"text": [
"psychological conditions"
],
"offsets": [
[
1665,
1689
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T124",
"type": "Condition",
"text": [
"Neuropsychiatric",
"symptoms"
],
"offsets": [
[
1626,
1642
],
[
1653,
1661
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T127",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
1696,
1705
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T128",
"type": "Condition",
"text": [
"breast-feeding"
],
"offsets": [
[
1709,
1723
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T129",
"type": "Drug",
"text": [
"B cell",
"-depleting agents"
],
"offsets": [
[
1750,
1756
],
[
1770,
1787
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T130",
"type": "Drug",
"text": [
"lymphocyte-depleting agents"
],
"offsets": [
[
1760,
1787
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T131",
"type": "Drug",
"text": [
"rituximab"
],
"offsets": [
[
1793,
1802
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T132",
"type": "Drug",
"text": [
"Campath"
],
"offsets": [
[
1804,
1811
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T133",
"type": "Scope",
"text": [
"rituximab, Campath"
],
"offsets": [
[
1793,
1811
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T134",
"type": "Scope",
"text": [
"B cell or lymphocyte-depleting agents"
],
"offsets": [
[
1750,
1787
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T135",
"type": "Temporal",
"text": [
"Prior"
],
"offsets": [
[
1729,
1734
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T136",
"type": "Drug",
"text": [
"leukotriene pathway inhibitor"
],
"offsets": [
[
1900,
1929
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T137",
"type": "Qualifier",
"text": [
"another"
],
"offsets": [
[
1892,
1899
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T139",
"type": "Multiplier",
"text": [
"regular use"
],
"offsets": [
[
1877,
1888
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T141",
"type": "Temporal",
"text": [
"Concurrent"
],
"offsets": [
[
1866,
1876
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T142",
"type": "Condition",
"text": [
"chronic renal insufficiency"
],
"offsets": [
[
2046,
2073
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T143",
"type": "Qualifier",
"text": [
"Significant"
],
"offsets": [
[
2034,
2045
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T145",
"type": "Measurement",
"text": [
"alanine transaminase"
],
"offsets": [
[
2095,
2115
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T146",
"type": "Measurement",
"text": [
"aspartate transaminase"
],
"offsets": [
[
2117,
2139
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T147",
"type": "Value",
"text": [
">3 × upper limit of normal (ULN)"
],
"offsets": [
[
2148,
2180
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T148",
"type": "Measurement",
"text": [
"Transaminases",
"levels"
],
"offsets": [
[
2080,
2093
],
[
2141,
2147
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T149",
"type": "Scope",
"text": [
"alanine transaminase, aspartate transaminase"
],
"offsets": [
[
2095,
2139
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T150",
"type": "Measurement",
"text": [
"bilirubin level"
],
"offsets": [
[
2188,
2203
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T151",
"type": "Value",
"text": [
">2 × ULN"
],
"offsets": [
[
2204,
2212
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T152",
"type": "Measurement",
"text": [
"Absolute neutrophil count"
],
"offsets": [
[
2219,
2244
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T153",
"type": "Value",
"text": [
"<1500 mm3"
],
"offsets": [
[
2245,
2254
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T154",
"type": "Measurement",
"text": [
"Hemoglobin concentration"
],
"offsets": [
[
2261,
2285
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T155",
"type": "Value",
"text": [
"<9 g/dL"
],
"offsets": [
[
2286,
2293
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T156",
"type": "Temporal",
"text": [
"at Screening"
],
"offsets": [
[
2294,
2306
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T157",
"type": "Reference_point",
"text": [
"Screening"
],
"offsets": [
[
2297,
2306
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T158",
"type": "Condition",
"text": [
"Hepatic dysfunction"
],
"offsets": [
[
2313,
2332
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T159",
"type": "Measurement",
"text": [
"Child-Pugh"
],
"offsets": [
[
2347,
2357
]
],
"normalized": []
},
{
"id": "NCT02664558_exc_T160",
"type": "Value",
"text": [
"Class B or C"
],
"offsets": [
[
2358,
2370
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02664558_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02664558_exc_T34",
"arg2_id": "NCT02664558_exc_T35",
"normalized": []
},
{
"id": "NCT02664558_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02664558_exc_T34",
"arg2_id": "NCT02664558_exc_T36",
"normalized": []
},
{
"id": "NCT02664558_exc_R3",
"type": "Has_index",
"arg1_id": "NCT02664558_exc_T38",
"arg2_id": "NCT02664558_exc_T39",
"normalized": []
},
{
"id": "NCT02664558_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02664558_exc_T37",
"arg2_id": "NCT02664558_exc_T38",
"normalized": []
},
{
"id": "NCT02664558_exc_R5",
"type": "Has_value",
"arg1_id": "NCT02664558_exc_T47",
"arg2_id": "NCT02664558_exc_T48",
"normalized": []
},
{
"id": "NCT02664558_exc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT02664558_exc_T42",
"arg2_id": "NCT02664558_exc_T43",
"normalized": []
},
{
"id": "NCT02664558_exc_R7",
"type": "AND",
"arg1_id": "NCT02664558_exc_T46",
"arg2_id": "NCT02664558_exc_T47",
"normalized": []
},
{
"id": "NCT02664558_exc_R8",
"type": "Has_temporal",
"arg1_id": "NCT02664558_exc_T49",
"arg2_id": "NCT02664558_exc_T40",
"normalized": []
},
{
"id": "NCT02664558_exc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT02664558_exc_T50",
"arg2_id": "NCT02664558_exc_T51",
"normalized": []
},
{
"id": "NCT02664558_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT02664558_exc_T50",
"arg2_id": "NCT02664558_exc_T52",
"normalized": []
},
{
"id": "NCT02664558_exc_R11",
"type": "Has_index",
"arg1_id": "NCT02664558_exc_T53",
"arg2_id": "NCT02664558_exc_T54",
"normalized": []
},
{
"id": "NCT02664558_exc_R12",
"type": "Has_temporal",
"arg1_id": "NCT02664558_exc_T50",
"arg2_id": "NCT02664558_exc_T53",
"normalized": []
},
{
"id": "NCT02664558_exc_R13",
"type": "Has_index",
"arg1_id": "NCT02664558_exc_T55",
"arg2_id": "NCT02664558_exc_T57",
"normalized": []
},
{
"id": "NCT02664558_exc_R14",
"type": "Subsumes",
"arg1_id": "NCT02664558_exc_T56",
"arg2_id": "NCT02664558_exc_T55",
"normalized": []
},
{
"id": "NCT02664558_exc_R15",
"type": "Has_scope",
"arg1_id": "NCT02664558_exc_T60",
"arg2_id": "NCT02664558_exc_T61",
"normalized": []
},
{
"id": "NCT02664558_exc_R16",
"type": "Has_temporal",
"arg1_id": "NCT02664558_exc_T62",
"arg2_id": "NCT02664558_exc_T65",
"normalized": []
},
{
"id": "NCT02664558_exc_R17",
"type": "Has_qualifier",
"arg1_id": "NCT02664558_exc_T67",
"arg2_id": "NCT02664558_exc_T68",
"normalized": []
},
{
"id": "NCT02664558_exc_R18",
"type": "Has_qualifier",
"arg1_id": "NCT02664558_exc_T72",
"arg2_id": "NCT02664558_exc_T73",
"normalized": []
},
{
"id": "NCT02664558_exc_R19",
"type": "Has_value",
"arg1_id": "NCT02664558_exc_T74",
"arg2_id": "NCT02664558_exc_T75",
"normalized": []
},
{
"id": "NCT02664558_exc_R20",
"type": "Has_qualifier",
"arg1_id": "NCT02664558_exc_T79",
"arg2_id": "NCT02664558_exc_T78",
"normalized": []
},
{
"id": "NCT02664558_exc_R21",
"type": "Has_multiplier",
"arg1_id": "NCT02664558_exc_T86",
"arg2_id": "NCT02664558_exc_T85",
"normalized": []
},
{
"id": "NCT02664558_exc_R23",
"type": "Has_scope",
"arg1_id": "NCT02664558_exc_T86",
"arg2_id": "NCT02664558_exc_T87",
"normalized": []
},
{
"id": "NCT02664558_exc_R24",
"type": "Has_multiplier",
"arg1_id": "NCT02664558_exc_T92",
"arg2_id": "NCT02664558_exc_T93",
"normalized": []
},
{
"id": "NCT02664558_exc_R25",
"type": "Subsumes",
"arg1_id": "NCT02664558_exc_T92",
"arg2_id": "NCT02664558_exc_T94",
"normalized": []
},
{
"id": "NCT02664558_exc_R26",
"type": "Has_value",
"arg1_id": "NCT02664558_exc_T98",
"arg2_id": "NCT02664558_exc_T99",
"normalized": []
},
{
"id": "NCT02664558_exc_R27",
"type": "Has_value",
"arg1_id": "NCT02664558_exc_T97",
"arg2_id": "NCT02664558_exc_T99",
"normalized": []
},
{
"id": "NCT02664558_exc_R28",
"type": "Subsumes",
"arg1_id": "NCT02664558_exc_T96",
"arg2_id": "NCT02664558_exc_T100",
"normalized": []
},
{
"id": "NCT02664558_exc_R29",
"type": "Has_index",
"arg1_id": "NCT02664558_exc_T104",
"arg2_id": "NCT02664558_exc_T105",
"normalized": []
},
{
"id": "NCT02664558_exc_R30",
"type": "Has_temporal",
"arg1_id": "NCT02664558_exc_T101",
"arg2_id": "NCT02664558_exc_T104",
"normalized": []
},
{
"id": "NCT02664558_exc_R31",
"type": "Has_value",
"arg1_id": "NCT02664558_exc_T106",
"arg2_id": "NCT02664558_exc_T107",
"normalized": []
},
{
"id": "NCT02664558_exc_R32",
"type": "Has_index",
"arg1_id": "NCT02664558_exc_T108",
"arg2_id": "NCT02664558_exc_T109",
"normalized": []
},
{
"id": "NCT02664558_exc_R33",
"type": "Has_temporal",
"arg1_id": "NCT02664558_exc_T106",
"arg2_id": "NCT02664558_exc_T108",
"normalized": []
},
{
"id": "NCT02664558_exc_R34",
"type": "Has_temporal",
"arg1_id": "NCT02664558_exc_T110",
"arg2_id": "NCT02664558_exc_T111",
"normalized": []
},
{
"id": "NCT02664558_exc_R35",
"type": "Has_temporal",
"arg1_id": "NCT02664558_exc_T112",
"arg2_id": "NCT02664558_exc_T114",
"normalized": []
},
{
"id": "NCT02664558_exc_R36",
"type": "Has_temporal",
"arg1_id": "NCT02664558_exc_T112",
"arg2_id": "NCT02664558_exc_T115",
"normalized": []
},
{
"id": "NCT02664558_exc_R37",
"type": "Has_qualifier",
"arg1_id": "NCT02664558_exc_T119",
"arg2_id": "NCT02664558_exc_T120",
"normalized": []
},
{
"id": "NCT02664558_exc_R38",
"type": "AND",
"arg1_id": "NCT02664558_exc_T118",
"arg2_id": "NCT02664558_exc_T119",
"normalized": []
},
{
"id": "NCT02664558_exc_R39",
"type": "Has_negation",
"arg1_id": "NCT02664558_exc_T118",
"arg2_id": "NCT02664558_exc_T117",
"normalized": []
},
{
"id": "NCT02664558_exc_R40",
"type": "Has_negation",
"arg1_id": "NCT02664558_exc_T116",
"arg2_id": "NCT02664558_exc_T117",
"normalized": []
},
{
"id": "NCT02664558_exc_R41",
"type": "Subsumes",
"arg1_id": "NCT02664558_exc_T134",
"arg2_id": "NCT02664558_exc_T133",
"normalized": []
},
{
"id": "NCT02664558_exc_R42",
"type": "Has_temporal",
"arg1_id": "NCT02664558_exc_T134",
"arg2_id": "NCT02664558_exc_T135",
"normalized": []
},
{
"id": "NCT02664558_exc_R43",
"type": "Has_qualifier",
"arg1_id": "NCT02664558_exc_T136",
"arg2_id": "NCT02664558_exc_T137",
"normalized": []
},
{
"id": "NCT02664558_exc_R44",
"type": "Has_multiplier",
"arg1_id": "NCT02664558_exc_T136",
"arg2_id": "NCT02664558_exc_T139",
"normalized": []
},
{
"id": "NCT02664558_exc_R45",
"type": "Has_temporal",
"arg1_id": "NCT02664558_exc_T136",
"arg2_id": "NCT02664558_exc_T141",
"normalized": []
},
{
"id": "NCT02664558_exc_R46",
"type": "Has_qualifier",
"arg1_id": "NCT02664558_exc_T142",
"arg2_id": "NCT02664558_exc_T143",
"normalized": []
},
{
"id": "NCT02664558_exc_R47",
"type": "Subsumes",
"arg1_id": "NCT02664558_exc_T148",
"arg2_id": "NCT02664558_exc_T149",
"normalized": []
},
{
"id": "NCT02664558_exc_R48",
"type": "Has_value",
"arg1_id": "NCT02664558_exc_T148",
"arg2_id": "NCT02664558_exc_T147",
"normalized": []
},
{
"id": "NCT02664558_exc_R49",
"type": "Has_value",
"arg1_id": "NCT02664558_exc_T150",
"arg2_id": "NCT02664558_exc_T151",
"normalized": []
},
{
"id": "NCT02664558_exc_R50",
"type": "Has_value",
"arg1_id": "NCT02664558_exc_T152",
"arg2_id": "NCT02664558_exc_T153",
"normalized": []
},
{
"id": "NCT02664558_exc_R51",
"type": "Has_value",
"arg1_id": "NCT02664558_exc_T154",
"arg2_id": "NCT02664558_exc_T155",
"normalized": []
},
{
"id": "NCT02664558_exc_R52",
"type": "Has_index",
"arg1_id": "NCT02664558_exc_T156",
"arg2_id": "NCT02664558_exc_T157",
"normalized": []
},
{
"id": "NCT02664558_exc_R53",
"type": "Has_temporal",
"arg1_id": "NCT02664558_exc_T154",
"arg2_id": "NCT02664558_exc_T156",
"normalized": []
},
{
"id": "NCT02664558_exc_R54",
"type": "Has_value",
"arg1_id": "NCT02664558_exc_T159",
"arg2_id": "NCT02664558_exc_T160",
"normalized": []
},
{
"id": "NCT02664558_exc_R55",
"type": "AND",
"arg1_id": "NCT02664558_exc_T158",
"arg2_id": "NCT02664558_exc_T159",
"normalized": []
}
] |
NCT02664558_inc
|
NCT02664558
|
[
{
"id": "NCT02664558_inc_text",
"type": "inclusion",
"text": [
"1. Male or female, 18-75 years old. \n2. Has a diagnosis of WHO Group 1 PAH. \n3. Right heart catheterization performed at Screening with results that are: \n1. Mean pulmonary arterial pressure ≥25 mmHg (at rest) and \n2. Pulmonary venous hypertension (measured as pulmonary capillary wedge pressure (PCWP) ≤15 mmHg. If PCWP is not available, then mean left atrial pressure or left ventricular end-diastolic pressure ≤15 mmHg in the absence of left atrial obstruction. and \n3. Pulmonary vascular resistance (PVR) ≥300 dyn•s/cm5 (3.75 Wood units) \n4. Has WHO/NYHA-FC of II or III. \n5. Be on stable dose of at least one of the following PAH-specific therapies: endothelin receptor antagonist, an agent acting on the nitric oxide pathway (phosphodiesterase type 5 inhibitor or soluble guanylate cyclase stimulator), and/or a prostacyclin or prostacyclin analog. \n6. Has a 6-minute walk distance that is ≥150 and ≤500 meters. \n7. Have a ventilation-perfusion scan that rules out thromboembolic disease. \n"
],
"offsets": [
[
0,
996
]
]
}
] |
[
{
"id": "NCT02664558_inc_T11",
"type": "Person",
"text": [
"Male"
],
"offsets": [
[
3,
7
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T12",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
11,
17
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T13",
"type": "Value",
"text": [
"18-75 years"
],
"offsets": [
[
19,
30
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T14",
"type": "Person",
"text": [
"years old"
],
"offsets": [
[
25,
34
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T15",
"type": "Measurement",
"text": [
"WHO Group"
],
"offsets": [
[
59,
68
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T16",
"type": "Value",
"text": [
"1"
],
"offsets": [
[
69,
70
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T17",
"type": "Condition",
"text": [
"PAH"
],
"offsets": [
[
71,
74
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T18",
"type": "Procedure",
"text": [
"Right heart catheterization"
],
"offsets": [
[
80,
107
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T20",
"type": "Temporal",
"text": [
"performed at Screening"
],
"offsets": [
[
108,
130
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T21",
"type": "Reference_point",
"text": [
"Screening"
],
"offsets": [
[
121,
130
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T22",
"type": "Measurement",
"text": [
"Mean pulmonary arterial pressure"
],
"offsets": [
[
158,
190
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T23",
"type": "Value",
"text": [
"≥25 mmHg"
],
"offsets": [
[
191,
199
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T24",
"type": "Qualifier",
"text": [
"at rest"
],
"offsets": [
[
201,
208
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T25",
"type": "Condition",
"text": [
"Pulmonary venous hypertension"
],
"offsets": [
[
218,
247
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T26",
"type": "Measurement",
"text": [
"pulmonary capillary wedge pressure (PCWP)"
],
"offsets": [
[
261,
302
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T27",
"type": "Value",
"text": [
"≤15 mmHg"
],
"offsets": [
[
303,
311
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T28",
"type": "Condition",
"text": [
"mean left atrial pressure"
],
"offsets": [
[
344,
369
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T29",
"type": "Condition",
"text": [
"left ventricular end-diastolic pressure"
],
"offsets": [
[
373,
412
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T30",
"type": "Value",
"text": [
"≤15 mmHg"
],
"offsets": [
[
413,
421
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T31",
"type": "Negation",
"text": [
"absence"
],
"offsets": [
[
429,
436
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T32",
"type": "Condition",
"text": [
"left atrial obstruction"
],
"offsets": [
[
440,
463
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T33",
"type": "Condition",
"text": [
"Pulmonary vascular resistance (PVR)"
],
"offsets": [
[
473,
508
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T34",
"type": "Value",
"text": [
"≥300 dyn•s/cm5"
],
"offsets": [
[
509,
523
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T35",
"type": "Value",
"text": [
"3.75 Wood units"
],
"offsets": [
[
525,
540
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T36",
"type": "Measurement",
"text": [
"WHO/NYHA-FC"
],
"offsets": [
[
550,
561
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T37",
"type": "Value",
"text": [
"II"
],
"offsets": [
[
565,
567
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T38",
"type": "Value",
"text": [
"III"
],
"offsets": [
[
571,
574
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T39",
"type": "Scope",
"text": [
"II or III"
],
"offsets": [
[
565,
574
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T40",
"type": "Qualifier",
"text": [
"stable dose"
],
"offsets": [
[
586,
597
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T41",
"type": "Multiplier",
"text": [
"at least one"
],
"offsets": [
[
601,
613
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T42",
"type": "Procedure",
"text": [
"PAH-specific therapies"
],
"offsets": [
[
631,
653
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T43",
"type": "Drug",
"text": [
"endothelin receptor antagonist"
],
"offsets": [
[
655,
685
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T44",
"type": "Drug",
"text": [
"agent acting on the nitric oxide pathway"
],
"offsets": [
[
690,
730
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T45",
"type": "Drug",
"text": [
"phosphodiesterase type 5 inhibitor"
],
"offsets": [
[
732,
766
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T46",
"type": "Drug",
"text": [
"soluble guanylate cyclase stimulator"
],
"offsets": [
[
770,
806
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T47",
"type": "Scope",
"text": [
"phosphodiesterase type 5 inhibitor or soluble guanylate cyclase stimulator"
],
"offsets": [
[
732,
806
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T48",
"type": "Drug",
"text": [
"prostacyclin",
"analog"
],
"offsets": [
[
818,
830
],
[
847,
853
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T49",
"type": "Drug",
"text": [
"prostacyclin analog"
],
"offsets": [
[
834,
853
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T50",
"type": "Scope",
"text": [
"endothelin receptor antagonist, an agent acting on the nitric oxide pathway (phosphodiesterase type 5 inhibitor or soluble guanylate cyclase stimulator), and/or a prostacyclin or prostacyclin analog"
],
"offsets": [
[
655,
853
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T51",
"type": "Measurement",
"text": [
"6-minute walk distance"
],
"offsets": [
[
865,
887
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T52",
"type": "Value",
"text": [
"≥150 and ≤500 meters"
],
"offsets": [
[
896,
916
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T53",
"type": "Procedure",
"text": [
"ventilation-perfusion scan"
],
"offsets": [
[
929,
955
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T54",
"type": "Condition",
"text": [
"thromboembolic disease"
],
"offsets": [
[
971,
993
]
],
"normalized": []
},
{
"id": "NCT02664558_inc_T56",
"type": "Negation",
"text": [
"rules out"
],
"offsets": [
[
961,
970
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02664558_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02664558_inc_T14",
"arg2_id": "NCT02664558_inc_T13",
"normalized": []
},
{
"id": "NCT02664558_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02664558_inc_T15",
"arg2_id": "NCT02664558_inc_T16",
"normalized": []
},
{
"id": "NCT02664558_inc_R3",
"type": "AND",
"arg1_id": "NCT02664558_inc_T17",
"arg2_id": "NCT02664558_inc_T15",
"normalized": []
},
{
"id": "NCT02664558_inc_R4",
"type": "Has_index",
"arg1_id": "NCT02664558_inc_T20",
"arg2_id": "NCT02664558_inc_T21",
"normalized": []
},
{
"id": "NCT02664558_inc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02664558_inc_T18",
"arg2_id": "NCT02664558_inc_T20",
"normalized": []
},
{
"id": "NCT02664558_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02664558_inc_T22",
"arg2_id": "NCT02664558_inc_T23",
"normalized": []
},
{
"id": "NCT02664558_inc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02664558_inc_T22",
"arg2_id": "NCT02664558_inc_T24",
"normalized": []
},
{
"id": "NCT02664558_inc_R8",
"type": "Has_value",
"arg1_id": "NCT02664558_inc_T26",
"arg2_id": "NCT02664558_inc_T27",
"normalized": []
},
{
"id": "NCT02664558_inc_R9",
"type": "AND",
"arg1_id": "NCT02664558_inc_T25",
"arg2_id": "NCT02664558_inc_T26",
"normalized": []
},
{
"id": "NCT02664558_inc_R10",
"type": "Has_value",
"arg1_id": "NCT02664558_inc_T29",
"arg2_id": "NCT02664558_inc_T30",
"normalized": []
},
{
"id": "NCT02664558_inc_R11",
"type": "Has_value",
"arg1_id": "NCT02664558_inc_T28",
"arg2_id": "NCT02664558_inc_T30",
"normalized": []
},
{
"id": "NCT02664558_inc_R12",
"type": "Has_negation",
"arg1_id": "NCT02664558_inc_T32",
"arg2_id": "NCT02664558_inc_T31",
"normalized": []
},
{
"id": "NCT02664558_inc_R13",
"type": "Subsumes",
"arg1_id": "NCT02664558_inc_T34",
"arg2_id": "NCT02664558_inc_T35",
"normalized": []
},
{
"id": "NCT02664558_inc_R14",
"type": "Has_value",
"arg1_id": "NCT02664558_inc_T33",
"arg2_id": "NCT02664558_inc_T34",
"normalized": []
},
{
"id": "NCT02664558_inc_R15",
"type": "Has_scope",
"arg1_id": "NCT02664558_inc_T36",
"arg2_id": "NCT02664558_inc_T39",
"normalized": []
},
{
"id": "NCT02664558_inc_R16",
"type": "Subsumes",
"arg1_id": "NCT02664558_inc_T44",
"arg2_id": "NCT02664558_inc_T47",
"normalized": []
},
{
"id": "NCT02664558_inc_R17",
"type": "Subsumes",
"arg1_id": "NCT02664558_inc_T42",
"arg2_id": "NCT02664558_inc_T50",
"normalized": []
},
{
"id": "NCT02664558_inc_R18",
"type": "Has_multiplier",
"arg1_id": "NCT02664558_inc_T42",
"arg2_id": "NCT02664558_inc_T41",
"normalized": []
},
{
"id": "NCT02664558_inc_R19",
"type": "Has_qualifier",
"arg1_id": "NCT02664558_inc_T42",
"arg2_id": "NCT02664558_inc_T40",
"normalized": []
},
{
"id": "NCT02664558_inc_R20",
"type": "Has_value",
"arg1_id": "NCT02664558_inc_T51",
"arg2_id": "NCT02664558_inc_T52",
"normalized": []
},
{
"id": "NCT02664558_inc_R21",
"type": "Has_negation",
"arg1_id": "NCT02664558_inc_T54",
"arg2_id": "NCT02664558_inc_T56",
"normalized": []
},
{
"id": "NCT02664558_inc_R22",
"type": "AND",
"arg1_id": "NCT02664558_inc_T54",
"arg2_id": "NCT02664558_inc_T53",
"normalized": []
}
] |
NCT02667730_exc
|
NCT02667730
|
[
{
"id": "NCT02667730_exc_text",
"type": "exclusion",
"text": [
"Diagnosis of ankle fracture or ligament rupture\nHas planned release from the Canadian Armed Forces within one year;\nDocumented restrictions on military duties\nHas known intolerance or documented adverse reaction to acetaminophen or naproxen or celecoxib\nDocumented history of liver or kidney problems\npregnant or breastfeeding\n"
],
"offsets": [
[
0,
327
]
]
}
] |
[
{
"id": "NCT02667730_exc_T1",
"type": "Condition",
"text": [
"ankle fracture"
],
"offsets": [
[
13,
27
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T2",
"type": "Condition",
"text": [
"ligament rupture"
],
"offsets": [
[
31,
47
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T3",
"type": "Observation",
"text": [
"release from the Canadian Armed Forces"
],
"offsets": [
[
60,
98
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T4",
"type": "Temporal",
"text": [
"within one year"
],
"offsets": [
[
99,
114
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T5",
"type": "Observation",
"text": [
"restrictions on military duties"
],
"offsets": [
[
127,
158
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T6",
"type": "Drug",
"text": [
"acetaminophen"
],
"offsets": [
[
215,
228
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T7",
"type": "Drug",
"text": [
"naproxen"
],
"offsets": [
[
232,
240
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T8",
"type": "Drug",
"text": [
"celecoxib"
],
"offsets": [
[
244,
253
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T9",
"type": "Condition",
"text": [
"adverse reaction"
],
"offsets": [
[
195,
211
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T10",
"type": "Scope",
"text": [
"acetaminophen or naproxen or celecoxib"
],
"offsets": [
[
215,
253
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T11",
"type": "Condition",
"text": [
"intolerance"
],
"offsets": [
[
169,
180
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T12",
"type": "Scope",
"text": [
"intolerance or documented adverse reaction"
],
"offsets": [
[
169,
211
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T13",
"type": "Condition",
"text": [
"kidney problems"
],
"offsets": [
[
285,
300
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T14",
"type": "Condition",
"text": [
"r or",
"lems\npre"
],
"offsets": [
[
280,
284
],
[
296,
304
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T15",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
265,
272
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T16",
"type": "Scope",
"text": [
"liver or kidney problems"
],
"offsets": [
[
276,
300
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T17",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
301,
309
]
],
"normalized": []
},
{
"id": "NCT02667730_exc_T18",
"type": "Observation",
"text": [
"breastfeeding"
],
"offsets": [
[
313,
326
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02667730_exc_R1",
"type": "Has_temporal",
"arg1_id": "NCT02667730_exc_T3",
"arg2_id": "NCT02667730_exc_T4",
"normalized": []
},
{
"id": "NCT02667730_exc_R2",
"type": "Has_scope",
"arg1_id": "NCT02667730_exc_T12",
"arg2_id": "NCT02667730_exc_T10",
"normalized": []
},
{
"id": "NCT02667730_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02667730_exc_T16",
"arg2_id": "NCT02667730_exc_T15",
"normalized": []
}
] |
NCT02667730_inc
|
NCT02667730
|
[
{
"id": "NCT02667730_inc_text",
"type": "inclusion",
"text": [
"Acquired acute ankle injury (injured less than 48 hours ago);\nClinical diagnosis of a Grade I or II ankle sprain\nIs eligible to receive comprehensive medical care from Garrison Petawawa\n"
],
"offsets": [
[
0,
186
]
]
}
] |
[
{
"id": "NCT02667730_inc_T1",
"type": "Condition",
"text": [
"acute ankle injury"
],
"offsets": [
[
9,
27
]
],
"normalized": []
},
{
"id": "NCT02667730_inc_T2",
"type": "Qualifier",
"text": [
"Acquired"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "NCT02667730_inc_T3",
"type": "Temporal",
"text": [
"less than 48 hours ago"
],
"offsets": [
[
37,
59
]
],
"normalized": []
},
{
"id": "NCT02667730_inc_T4",
"type": "Qualifier",
"text": [
"Grade I"
],
"offsets": [
[
86,
93
]
],
"normalized": []
},
{
"id": "NCT02667730_inc_T5",
"type": "Qualifier",
"text": [
"rade",
"I"
],
"offsets": [
[
87,
91
],
[
98,
99
]
],
"normalized": []
},
{
"id": "NCT02667730_inc_T6",
"type": "Condition",
"text": [
"ankle sprain"
],
"offsets": [
[
100,
112
]
],
"normalized": []
},
{
"id": "NCT02667730_inc_T7",
"type": "Scope",
"text": [
"Grade I or II"
],
"offsets": [
[
86,
99
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02667730_inc_R1",
"type": "Has_temporal",
"arg1_id": "NCT02667730_inc_T1",
"arg2_id": "NCT02667730_inc_T3",
"normalized": []
},
{
"id": "NCT02667730_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02667730_inc_T1",
"arg2_id": "NCT02667730_inc_T2",
"normalized": []
},
{
"id": "NCT02667730_inc_R3",
"type": "Has_scope",
"arg1_id": "NCT02667730_inc_T6",
"arg2_id": "NCT02667730_inc_T7",
"normalized": []
}
] |
NCT02668016_exc
|
NCT02668016
|
[
{
"id": "NCT02668016_exc_text",
"type": "exclusion",
"text": [
"History of neuropathy\nRegularly taking prescribed analgesia\nHistory of a chronic pain condition\nHistory of severe mental illness (as their experience of symptoms may already be altered)\nCurrent use of fibrates (because of the risk of interaction with statins but will not exclude participants taking ezetimibe).\nSevere previous reaction or reaction considered immunological, such as anaphylaxis, facial swelling, severe rash, muscle ache with rise in serum creatine kinase, inflammatory myopathy, rhabdomyolysis or liver function abnormalities (aspartate transaminase (AST) or alanine transaminase (ALT) greater than 3 times upper limit or normal).\nSide-effects taking longer than 2 weeks to develop (because in such participants much longer blocks of treatment would be required, if the present study is positive such studies will be planned for the future)*.\nHistory of statin intolerance with drug interaction to antiretroviral drugs.\nHistory of statin intolerance to any other drug.\nPregnant or breast feeding.\nSide effects taking longer than 2 weeks to present.\nIn clinical judgement of study doctor, participant should not participate.\n"
],
"offsets": [
[
0,
1142
]
]
}
] |
[
{
"id": "NCT02668016_exc_T1",
"type": "Condition",
"text": [
"neuropathy"
],
"offsets": [
[
11,
21
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T2",
"type": "Drug",
"text": [
"analgesia"
],
"offsets": [
[
50,
59
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T3",
"type": "Qualifier",
"text": [
"Regularly"
],
"offsets": [
[
22,
31
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T4",
"type": "Condition",
"text": [
"chronic pain"
],
"offsets": [
[
73,
85
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T5",
"type": "Condition",
"text": [
"mental illness"
],
"offsets": [
[
114,
128
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T6",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
107,
113
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T7",
"type": "Drug",
"text": [
"fibrates"
],
"offsets": [
[
201,
209
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T8",
"type": "Condition",
"text": [
"anaphylaxis"
],
"offsets": [
[
383,
394
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T9",
"type": "Condition",
"text": [
"facial swelling,"
],
"offsets": [
[
396,
412
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T10",
"type": "Condition",
"text": [
"severe rash"
],
"offsets": [
[
413,
424
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T11",
"type": "Condition",
"text": [
"muscle ache"
],
"offsets": [
[
426,
437
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T12",
"type": "Measurement",
"text": [
"serum creatine kinase"
],
"offsets": [
[
451,
472
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T13",
"type": "Value",
"text": [
"rise"
],
"offsets": [
[
443,
447
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T14",
"type": "Condition",
"text": [
"inflammatory myopathy"
],
"offsets": [
[
474,
495
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T15",
"type": "Condition",
"text": [
"rhabdomyolysis"
],
"offsets": [
[
497,
511
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T16",
"type": "Condition",
"text": [
"liver function abnormalities"
],
"offsets": [
[
515,
543
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T17",
"type": "Measurement",
"text": [
"aspartate transaminase"
],
"offsets": [
[
545,
567
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T18",
"type": "Measurement",
"text": [
"AST"
],
"offsets": [
[
569,
572
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T19",
"type": "Measurement",
"text": [
"alanine transaminase"
],
"offsets": [
[
577,
597
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T20",
"type": "Measurement",
"text": [
"ALT"
],
"offsets": [
[
599,
602
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T21",
"type": "Value",
"text": [
"greater than 3 times upper limit or normal"
],
"offsets": [
[
604,
646
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T22",
"type": "Scope",
"text": [
"aspartate transaminase (AST) or alanine transaminase (ALT)"
],
"offsets": [
[
545,
603
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T24",
"type": "Condition",
"text": [
"intolerance"
],
"offsets": [
[
879,
890
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T25",
"type": "Drug",
"text": [
"statin"
],
"offsets": [
[
872,
878
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T26",
"type": "Drug",
"text": [
"antiretroviral drugs"
],
"offsets": [
[
916,
936
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T27",
"type": "Condition",
"text": [
"intolerance"
],
"offsets": [
[
956,
967
]
],
"normalized": []
},
{
"id": "NCT02668016_exc_T28",
"type": "Drug",
"text": [
"statin"
],
"offsets": [
[
949,
955
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02668016_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02668016_exc_T2",
"arg2_id": "NCT02668016_exc_T3",
"normalized": []
},
{
"id": "NCT02668016_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02668016_exc_T5",
"arg2_id": "NCT02668016_exc_T6",
"normalized": []
},
{
"id": "NCT02668016_exc_R3",
"type": "AND",
"arg1_id": "NCT02668016_exc_T11",
"arg2_id": "NCT02668016_exc_T12",
"normalized": []
},
{
"id": "NCT02668016_exc_R4",
"type": "Has_value",
"arg1_id": "NCT02668016_exc_T12",
"arg2_id": "NCT02668016_exc_T13",
"normalized": []
},
{
"id": "NCT02668016_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT02668016_exc_T17",
"arg2_id": "NCT02668016_exc_T18",
"normalized": []
},
{
"id": "NCT02668016_exc_R6",
"type": "Subsumes",
"arg1_id": "NCT02668016_exc_T19",
"arg2_id": "NCT02668016_exc_T20",
"normalized": []
},
{
"id": "NCT02668016_exc_R7",
"type": "Has_value",
"arg1_id": "NCT02668016_exc_T22",
"arg2_id": "NCT02668016_exc_T21",
"normalized": []
},
{
"id": "NCT02668016_exc_R8",
"type": "Subsumes",
"arg1_id": "NCT02668016_exc_T16",
"arg2_id": "NCT02668016_exc_T22",
"normalized": []
},
{
"id": "NCT02668016_exc_R9",
"type": "AND",
"arg1_id": "NCT02668016_exc_T24",
"arg2_id": "NCT02668016_exc_T25",
"normalized": []
},
{
"id": "NCT02668016_exc_R10",
"type": "AND",
"arg1_id": "NCT02668016_exc_T27",
"arg2_id": "NCT02668016_exc_T28",
"normalized": []
}
] |
NCT02668016_inc
|
NCT02668016
|
[
{
"id": "NCT02668016_inc_text",
"type": "inclusion",
"text": [
"Aged 18 years or older\nPreviously taken one or more statins\nWithdrawn from statins because of perceived side effects\nDeveloped side effects within 2 weeks of initiation\nClinical indication for statins for primary or secondary prevention of cardiovascular disease or dyslipidaemia, on either no medication or non-statin lipid lowering therapy (e.g, ezetimibe)\n"
],
"offsets": [
[
0,
359
]
]
}
] |
[
{
"id": "NCT02668016_inc_T1",
"type": "Person",
"text": [
"Aged"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "NCT02668016_inc_T2",
"type": "Value",
"text": [
"18 years or older"
],
"offsets": [
[
5,
22
]
],
"normalized": []
},
{
"id": "NCT02668016_inc_T3",
"type": "Multiplier",
"text": [
"one or more"
],
"offsets": [
[
40,
51
]
],
"normalized": []
},
{
"id": "NCT02668016_inc_T4",
"type": "Drug",
"text": [
"statins"
],
"offsets": [
[
52,
59
]
],
"normalized": []
},
{
"id": "NCT02668016_inc_T6",
"type": "Condition",
"text": [
"side effects"
],
"offsets": [
[
127,
139
]
],
"normalized": []
},
{
"id": "NCT02668016_inc_T7",
"type": "Temporal",
"text": [
"within 2 weeks of initiation"
],
"offsets": [
[
140,
168
]
],
"normalized": []
},
{
"id": "NCT02668016_inc_T8",
"type": "Reference_point",
"text": [
"initiation"
],
"offsets": [
[
158,
168
]
],
"normalized": []
},
{
"id": "NCT02668016_inc_T9",
"type": "Condition",
"text": [
"indication"
],
"offsets": [
[
178,
188
]
],
"normalized": []
},
{
"id": "NCT02668016_inc_T10",
"type": "Drug",
"text": [
"statins"
],
"offsets": [
[
193,
200
]
],
"normalized": []
},
{
"id": "NCT02668016_inc_T11",
"type": "Observation",
"text": [
"prevention of cardiovascular disease"
],
"offsets": [
[
226,
262
]
],
"normalized": []
},
{
"id": "NCT02668016_inc_T12",
"type": "Qualifier",
"text": [
"secondary"
],
"offsets": [
[
216,
225
]
],
"normalized": []
},
{
"id": "NCT02668016_inc_T13",
"type": "Qualifier",
"text": [
"primary"
],
"offsets": [
[
205,
212
]
],
"normalized": []
},
{
"id": "NCT02668016_inc_T14",
"type": "Condition",
"text": [
"dyslipidaemia"
],
"offsets": [
[
266,
279
]
],
"normalized": []
},
{
"id": "NCT02668016_inc_T15",
"type": "Scope",
"text": [
"primary or secondary"
],
"offsets": [
[
205,
225
]
],
"normalized": []
},
{
"id": "NCT02668016_inc_T16",
"type": "Scope",
"text": [
"primary or secondary prevention of cardiovascular disease or dyslipidaemia"
],
"offsets": [
[
205,
279
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02668016_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02668016_inc_T1",
"arg2_id": "NCT02668016_inc_T2",
"normalized": []
},
{
"id": "NCT02668016_inc_R2",
"type": "Has_multiplier",
"arg1_id": "NCT02668016_inc_T4",
"arg2_id": "NCT02668016_inc_T3",
"normalized": []
},
{
"id": "NCT02668016_inc_R3",
"type": "Has_index",
"arg1_id": "NCT02668016_inc_T7",
"arg2_id": "NCT02668016_inc_T8",
"normalized": []
},
{
"id": "NCT02668016_inc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02668016_inc_T6",
"arg2_id": "NCT02668016_inc_T7",
"normalized": []
},
{
"id": "NCT02668016_inc_R5",
"type": "AND",
"arg1_id": "NCT02668016_inc_T9",
"arg2_id": "NCT02668016_inc_T10",
"normalized": []
},
{
"id": "NCT02668016_inc_R6",
"type": "Has_scope",
"arg1_id": "NCT02668016_inc_T11",
"arg2_id": "NCT02668016_inc_T15",
"normalized": []
},
{
"id": "NCT02668016_inc_R7",
"type": "Subsumes",
"arg1_id": "NCT02668016_inc_T9",
"arg2_id": "NCT02668016_inc_T16",
"normalized": []
}
] |
NCT02668978_exc
|
NCT02668978
|
[
{
"id": "NCT02668978_exc_text",
"type": "exclusion",
"text": [
"Traumatic pulmonary contusion or laceration\nLung reduction surgery\nPlanned removal of more than 10 lung lesions\nPneumonectomy\nKnown hypersensitivity to bovine protein\nKnown hypersensitivity to Brilliant Blue FCF (E133)\nPresence of active infection\n"
],
"offsets": [
[
0,
248
]
]
}
] |
[
{
"id": "NCT02668978_exc_T1",
"type": "Condition",
"text": [
"pulmonary contusion"
],
"offsets": [
[
10,
29
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T2",
"type": "Condition",
"text": [
"laceration"
],
"offsets": [
[
33,
43
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T3",
"type": "Qualifier",
"text": [
"Traumatic"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T4",
"type": "Scope",
"text": [
"pulmonary contusion or laceration"
],
"offsets": [
[
10,
43
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T5",
"type": "Procedure",
"text": [
"Lung reduction surgery"
],
"offsets": [
[
44,
66
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T6",
"type": "Multiplier",
"text": [
"more than 10"
],
"offsets": [
[
86,
98
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T7",
"type": "Condition",
"text": [
"lung lesions"
],
"offsets": [
[
99,
111
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T8",
"type": "Mood",
"text": [
"Planned"
],
"offsets": [
[
67,
74
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T9",
"type": "Procedure",
"text": [
"removal"
],
"offsets": [
[
75,
82
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T10",
"type": "Procedure",
"text": [
"Pneumonectomy"
],
"offsets": [
[
112,
125
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T11",
"type": "Condition",
"text": [
"hypersensitivity"
],
"offsets": [
[
132,
148
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T12",
"type": "Drug",
"text": [
"bovine protein"
],
"offsets": [
[
152,
166
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T13",
"type": "Condition",
"text": [
"hypersensitivity"
],
"offsets": [
[
173,
189
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T14",
"type": "Drug",
"text": [
"Brilliant Blue FCF (E133)"
],
"offsets": [
[
193,
218
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T15",
"type": "Drug",
"text": [
"Brilliant Blue FCF (E133)"
],
"offsets": [
[
193,
218
]
],
"normalized": []
},
{
"id": "NCT02668978_exc_T16",
"type": "Condition",
"text": [
"active infection"
],
"offsets": [
[
231,
247
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02668978_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02668978_exc_T4",
"arg2_id": "NCT02668978_exc_T3",
"normalized": []
},
{
"id": "NCT02668978_exc_R2",
"type": "Has_multiplier",
"arg1_id": "NCT02668978_exc_T7",
"arg2_id": "NCT02668978_exc_T6",
"normalized": []
},
{
"id": "NCT02668978_exc_R3",
"type": "AND",
"arg1_id": "NCT02668978_exc_T11",
"arg2_id": "NCT02668978_exc_T12",
"normalized": []
},
{
"id": "NCT02668978_exc_R4",
"type": "AND",
"arg1_id": "NCT02668978_exc_T13",
"arg2_id": "NCT02668978_exc_T14",
"normalized": []
},
{
"id": "NCT02668978_exc_R5",
"type": "AND",
"arg1_id": "NCT02668978_exc_T13",
"arg2_id": "NCT02668978_exc_T15",
"normalized": []
}
] |
NCT02668978_inc
|
NCT02668978
|
[
{
"id": "NCT02668978_inc_text",
"type": "inclusion",
"text": [
"Patients over the age of 18 years who are able to give their informed consent\nLobar and sublobar resections\nOpen, video-assisted thoracoscopic or robotic surgeries\nDiagnostic or therapeutic procedures\n"
],
"offsets": [
[
0,
201
]
]
}
] |
[
{
"id": "NCT02668978_inc_T1",
"type": "Person",
"text": [
"over the age of 18 years"
],
"offsets": [
[
9,
33
]
],
"normalized": []
},
{
"id": "NCT02668978_inc_T2",
"type": "Observation",
"text": [
"able to give their informed consent"
],
"offsets": [
[
42,
77
]
],
"normalized": []
},
{
"id": "NCT02668978_inc_T3",
"type": "Procedure",
"text": [
"sublobar resections"
],
"offsets": [
[
88,
107
]
],
"normalized": []
},
{
"id": "NCT02668978_inc_T4",
"type": "Procedure",
"text": [
"obar",
"esections"
],
"offsets": [
[
79,
83
],
[
98,
107
]
],
"normalized": []
},
{
"id": "NCT02668978_inc_T5",
"type": "Procedure",
"text": [
"robotic surgeries"
],
"offsets": [
[
146,
163
]
],
"normalized": []
},
{
"id": "NCT02668978_inc_T6",
"type": "Qualifier",
"text": [
"video-assisted"
],
"offsets": [
[
114,
128
]
],
"normalized": []
},
{
"id": "NCT02668978_inc_T7",
"type": "Procedure",
"text": [
"oracoscopic o",
"rgeries\nD"
],
"offsets": [
[
131,
144
],
[
156,
165
]
],
"normalized": []
},
{
"id": "NCT02668978_inc_T8",
"type": "Scope",
"text": [
"thoracoscopic or robotic surgeries"
],
"offsets": [
[
129,
163
]
],
"normalized": []
},
{
"id": "NCT02668978_inc_T9",
"type": "Procedure",
"text": [
"therapeutic procedures"
],
"offsets": [
[
178,
200
]
],
"normalized": []
},
{
"id": "NCT02668978_inc_T10",
"type": "Procedure",
"text": [
"gnostic or",
"cedures"
],
"offsets": [
[
167,
177
],
[
193,
200
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02668978_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02668978_inc_T8",
"arg2_id": "NCT02668978_inc_T6",
"normalized": []
}
] |
NCT02671318_exc
|
NCT02671318
|
[
{
"id": "NCT02671318_exc_text",
"type": "exclusion",
"text": [
"Re-transplant;\nPatients with any panel reactive antibody (PRA) equal to or above 50%, class I or class II;\nAcute rejection episode in the last 30 days, or episode > 2A in the Banff criteria;\nGFR (MDRD) < 40 ml/min;\nProteinuria > 0,5 g/l;\nHemoglobin < 10 g/l and/or leucocytes < 4000 cels/mm3 and/or platelets < 150.000 cels/mm3;\nTriglycerides > 500 mg/dl with or without use of fibrate;\nCholesterol total > 300 mg/dl with or without use of statin;\nHepatic abnormalities;\nSignificant periphery edema;\nPulmonary abnormalities or breast x-ray abnormalities;\nHyper sensibility to sirolimus formula;\n"
],
"offsets": [
[
0,
595
]
]
}
] |
[
{
"id": "NCT02671318_exc_T1",
"type": "Procedure",
"text": [
"Re-transplant"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T2",
"type": "Measurement",
"text": [
"panel reactive antibody"
],
"offsets": [
[
33,
56
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T3",
"type": "Measurement",
"text": [
"PRA"
],
"offsets": [
[
58,
61
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T4",
"type": "Value",
"text": [
"equal to or above 50%"
],
"offsets": [
[
63,
84
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T5",
"type": "Value",
"text": [
"class I"
],
"offsets": [
[
86,
93
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T6",
"type": "Value",
"text": [
"class II"
],
"offsets": [
[
97,
105
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T7",
"type": "Scope",
"text": [
"equal to or above 50%, class I or class II"
],
"offsets": [
[
63,
105
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T8",
"type": "Condition",
"text": [
"Acute rejection episode"
],
"offsets": [
[
107,
130
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T9",
"type": "Temporal",
"text": [
"last 30 days"
],
"offsets": [
[
138,
150
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T10",
"type": "Measurement",
"text": [
"Banff criteria"
],
"offsets": [
[
175,
189
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T11",
"type": "Value",
"text": [
"> 2A"
],
"offsets": [
[
163,
167
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T12",
"type": "Measurement",
"text": [
"GFR"
],
"offsets": [
[
191,
194
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T14",
"type": "Value",
"text": [
"< 40 ml/min"
],
"offsets": [
[
202,
213
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T13",
"type": "Condition",
"text": [
"Proteinuria"
],
"offsets": [
[
215,
226
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T15",
"type": "Multiplier",
"text": [
"> 0,5 g/l"
],
"offsets": [
[
227,
236
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T16",
"type": "Measurement",
"text": [
"Hemoglobin"
],
"offsets": [
[
238,
248
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T17",
"type": "Value",
"text": [
"< 10 g/l"
],
"offsets": [
[
249,
257
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T18",
"type": "Measurement",
"text": [
"leucocytes"
],
"offsets": [
[
265,
275
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T19",
"type": "Value",
"text": [
"< 4000 cels/mm3"
],
"offsets": [
[
276,
291
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T20",
"type": "Measurement",
"text": [
"platelets"
],
"offsets": [
[
299,
308
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T21",
"type": "Value",
"text": [
"< 150.000 cels/mm3"
],
"offsets": [
[
309,
327
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T22",
"type": "Measurement",
"text": [
"Triglycerides"
],
"offsets": [
[
329,
342
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T23",
"type": "Value",
"text": [
"> 500 mg/dl"
],
"offsets": [
[
343,
354
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T24",
"type": "Drug",
"text": [
"fibrate"
],
"offsets": [
[
378,
385
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T25",
"type": "Measurement",
"text": [
"Cholesterol total"
],
"offsets": [
[
387,
404
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T26",
"type": "Value",
"text": [
"> 300 mg/dl"
],
"offsets": [
[
405,
416
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T27",
"type": "Drug",
"text": [
"statin"
],
"offsets": [
[
440,
446
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T28",
"type": "Condition",
"text": [
"Hepatic abnormalities"
],
"offsets": [
[
448,
469
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T29",
"type": "Condition",
"text": [
"periphery edema"
],
"offsets": [
[
483,
498
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T30",
"type": "Qualifier",
"text": [
"Significant"
],
"offsets": [
[
471,
482
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T31",
"type": "Condition",
"text": [
"Pulmonary abnormalities"
],
"offsets": [
[
500,
523
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T32",
"type": "Procedure",
"text": [
"breast x-ray"
],
"offsets": [
[
527,
539
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T33",
"type": "Value",
"text": [
"abnormalities"
],
"offsets": [
[
540,
553
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T34",
"type": "Condition",
"text": [
"Hyper sensibility"
],
"offsets": [
[
555,
572
]
],
"normalized": []
},
{
"id": "NCT02671318_exc_T35",
"type": "Drug",
"text": [
"sirolimus"
],
"offsets": [
[
576,
585
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02671318_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT02671318_exc_T2",
"arg2_id": "NCT02671318_exc_T3",
"normalized": []
},
{
"id": "NCT02671318_exc_R2",
"type": "Has_scope",
"arg1_id": "NCT02671318_exc_T2",
"arg2_id": "NCT02671318_exc_T7",
"normalized": []
},
{
"id": "NCT02671318_exc_R3",
"type": "Has_value",
"arg1_id": "NCT02671318_exc_T10",
"arg2_id": "NCT02671318_exc_T11",
"normalized": []
},
{
"id": "NCT02671318_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02671318_exc_T8",
"arg2_id": "NCT02671318_exc_T9",
"normalized": []
},
{
"id": "NCT02671318_exc_R5",
"type": "Has_value",
"arg1_id": "NCT02671318_exc_T12",
"arg2_id": "NCT02671318_exc_T14",
"normalized": []
},
{
"id": "NCT02671318_exc_R6",
"type": "Has_multiplier",
"arg1_id": "NCT02671318_exc_T13",
"arg2_id": "NCT02671318_exc_T15",
"normalized": []
},
{
"id": "NCT02671318_exc_R7",
"type": "Has_value",
"arg1_id": "NCT02671318_exc_T16",
"arg2_id": "NCT02671318_exc_T17",
"normalized": []
},
{
"id": "NCT02671318_exc_R8",
"type": "Has_value",
"arg1_id": "NCT02671318_exc_T18",
"arg2_id": "NCT02671318_exc_T19",
"normalized": []
},
{
"id": "NCT02671318_exc_R9",
"type": "Has_value",
"arg1_id": "NCT02671318_exc_T20",
"arg2_id": "NCT02671318_exc_T21",
"normalized": []
},
{
"id": "NCT02671318_exc_R10",
"type": "Has_value",
"arg1_id": "NCT02671318_exc_T22",
"arg2_id": "NCT02671318_exc_T23",
"normalized": []
},
{
"id": "NCT02671318_exc_R11",
"type": "Has_value",
"arg1_id": "NCT02671318_exc_T25",
"arg2_id": "NCT02671318_exc_T26",
"normalized": []
},
{
"id": "NCT02671318_exc_R12",
"type": "Has_qualifier",
"arg1_id": "NCT02671318_exc_T29",
"arg2_id": "NCT02671318_exc_T30",
"normalized": []
},
{
"id": "NCT02671318_exc_R13",
"type": "Has_value",
"arg1_id": "NCT02671318_exc_T32",
"arg2_id": "NCT02671318_exc_T33",
"normalized": []
},
{
"id": "NCT02671318_exc_R14",
"type": "AND",
"arg1_id": "NCT02671318_exc_T34",
"arg2_id": "NCT02671318_exc_T35",
"normalized": []
}
] |
NCT02671318_inc
|
NCT02671318
|
[
{
"id": "NCT02671318_inc_text",
"type": "inclusion",
"text": [
"Adult kidney transplant recipients > 18 y.o.\nKidney Transplant recipients, after the first episode of cytomegalovirus infection, using the current immunosuppressive regimen: azathioprine or mycophenolate, tacrolimus and prednisone.\n"
],
"offsets": [
[
0,
232
]
]
}
] |
[
{
"id": "NCT02671318_inc_T1",
"type": "Procedure",
"text": [
"kidney transplant"
],
"offsets": [
[
6,
23
]
],
"normalized": []
},
{
"id": "NCT02671318_inc_T2",
"type": "Person",
"text": [
"Adult"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02671318_inc_T3",
"type": "Person",
"text": [
"y.o."
],
"offsets": [
[
40,
44
]
],
"normalized": []
},
{
"id": "NCT02671318_inc_T4",
"type": "Value",
"text": [
"> 18"
],
"offsets": [
[
35,
39
]
],
"normalized": []
},
{
"id": "NCT02671318_inc_T5",
"type": "Condition",
"text": [
"cytomegalovirus infection"
],
"offsets": [
[
102,
127
]
],
"normalized": []
},
{
"id": "NCT02671318_inc_T6",
"type": "Drug",
"text": [
"immunosuppressive regimen"
],
"offsets": [
[
147,
172
]
],
"normalized": []
},
{
"id": "NCT02671318_inc_T7",
"type": "Drug",
"text": [
"azathioprine"
],
"offsets": [
[
174,
186
]
],
"normalized": []
},
{
"id": "NCT02671318_inc_T8",
"type": "Drug",
"text": [
"mycophenolate"
],
"offsets": [
[
190,
203
]
],
"normalized": []
},
{
"id": "NCT02671318_inc_T9",
"type": "Drug",
"text": [
"tacrolimus"
],
"offsets": [
[
205,
215
]
],
"normalized": []
},
{
"id": "NCT02671318_inc_T10",
"type": "Drug",
"text": [
"prednisone"
],
"offsets": [
[
220,
230
]
],
"normalized": []
},
{
"id": "NCT02671318_inc_T11",
"type": "Scope",
"text": [
"azathioprine or mycophenolate, tacrolimus and prednisone"
],
"offsets": [
[
174,
230
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02671318_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02671318_inc_T3",
"arg2_id": "NCT02671318_inc_T4",
"normalized": []
},
{
"id": "NCT02671318_inc_R2",
"type": "AND",
"arg1_id": "NCT02671318_inc_T5",
"arg2_id": "NCT02671318_inc_T6",
"normalized": []
},
{
"id": "NCT02671318_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT02671318_inc_T6",
"arg2_id": "NCT02671318_inc_T11",
"normalized": []
}
] |
NCT02673359_exc
|
NCT02673359
|
[
{
"id": "NCT02673359_exc_text",
"type": "exclusion",
"text": [
"Age < 20 or > 35 years.\nCongenital uterine malformation.\nMultifetal pregnancy.\nKnown major fetal structural or chromosomal abnormality.\nKnown allergy or contraindication (relative or absolute) to progesterone therapy.\nPresence of contraindication to cervical cerclage.\nMedical conditions complicating pregnancy.\nVaginal bleeding.\n"
],
"offsets": [
[
0,
330
]
]
}
] |
[
{
"id": "NCT02673359_exc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T2",
"type": "Value",
"text": [
"< 20"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T3",
"type": "Value",
"text": [
"> 35 years"
],
"offsets": [
[
12,
22
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T4",
"type": "Scope",
"text": [
"< 20 or > 35 years"
],
"offsets": [
[
4,
22
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T5",
"type": "Condition",
"text": [
"Congenital uterine malformation"
],
"offsets": [
[
24,
55
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T6",
"type": "Condition",
"text": [
"Multifetal pregnancy"
],
"offsets": [
[
57,
77
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T7",
"type": "Condition",
"text": [
"chromosomal abnormality"
],
"offsets": [
[
111,
134
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T8",
"type": "Condition",
"text": [
"fetal structural"
],
"offsets": [
[
91,
107
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T9",
"type": "Qualifier",
"text": [
"major"
],
"offsets": [
[
85,
90
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T10",
"type": "Scope",
"text": [
"fetal structural or chromosomal abnormality"
],
"offsets": [
[
91,
134
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T11",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
142,
149
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T12",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
153,
169
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T13",
"type": "Qualifier",
"text": [
"relative"
],
"offsets": [
[
171,
179
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T14",
"type": "Qualifier",
"text": [
"absolute"
],
"offsets": [
[
183,
191
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T15",
"type": "Procedure",
"text": [
"progesterone therapy"
],
"offsets": [
[
196,
216
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T16",
"type": "Scope",
"text": [
"relative or absolute"
],
"offsets": [
[
171,
191
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T17",
"type": "Scope",
"text": [
"allergy or contraindication"
],
"offsets": [
[
142,
169
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T18",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
230,
246
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T19",
"type": "Procedure",
"text": [
"cervical cerclage"
],
"offsets": [
[
250,
267
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T20",
"type": "Condition",
"text": [
"Medical conditions"
],
"offsets": [
[
269,
287
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T21",
"type": "Qualifier",
"text": [
"complicating pregnancy"
],
"offsets": [
[
288,
310
]
],
"normalized": []
},
{
"id": "NCT02673359_exc_T22",
"type": "Condition",
"text": [
"Vaginal bleeding"
],
"offsets": [
[
312,
328
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02673359_exc_R1",
"type": "Has_scope",
"arg1_id": "NCT02673359_exc_T1",
"arg2_id": "NCT02673359_exc_T4",
"normalized": []
},
{
"id": "NCT02673359_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02673359_exc_T10",
"arg2_id": "NCT02673359_exc_T9",
"normalized": []
},
{
"id": "NCT02673359_exc_R3",
"type": "Has_scope",
"arg1_id": "NCT02673359_exc_T17",
"arg2_id": "NCT02673359_exc_T16",
"normalized": []
},
{
"id": "NCT02673359_exc_R4",
"type": "AND",
"arg1_id": "NCT02673359_exc_T17",
"arg2_id": "NCT02673359_exc_T15",
"normalized": []
}
] |
NCT02673359_inc
|
NCT02673359
|
[
{
"id": "NCT02673359_inc_text",
"type": "inclusion",
"text": [
"Women with singleton pregnancy.\nHistory of preterm labor and/or midtrimester miscarriage in a previous pregnancy.\nCervical length of 15-25 mm by transvaginal sonography (TVS) at 16-24 weeks of gestation.\n"
],
"offsets": [
[
0,
204
]
]
}
] |
[
{
"id": "NCT02673359_inc_T1",
"type": "Person",
"text": [
"Women"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02673359_inc_T2",
"type": "Condition",
"text": [
"singleton pregnancy"
],
"offsets": [
[
11,
30
]
],
"normalized": []
},
{
"id": "NCT02673359_inc_T3",
"type": "Condition",
"text": [
"preterm labor"
],
"offsets": [
[
43,
56
]
],
"normalized": []
},
{
"id": "NCT02673359_inc_T4",
"type": "Condition",
"text": [
"midtrimester miscarriage"
],
"offsets": [
[
64,
88
]
],
"normalized": []
},
{
"id": "NCT02673359_inc_T5",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
94,
102
]
],
"normalized": []
},
{
"id": "NCT02673359_inc_T6",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
103,
112
]
],
"normalized": []
},
{
"id": "NCT02673359_inc_T7",
"type": "Scope",
"text": [
"previous pregnancy"
],
"offsets": [
[
94,
112
]
],
"normalized": []
},
{
"id": "NCT02673359_inc_T8",
"type": "Scope",
"text": [
"preterm labor and/or midtrimester miscarriage"
],
"offsets": [
[
43,
88
]
],
"normalized": []
},
{
"id": "NCT02673359_inc_T9",
"type": "Measurement",
"text": [
"Cervical length"
],
"offsets": [
[
114,
129
]
],
"normalized": []
},
{
"id": "NCT02673359_inc_T10",
"type": "Value",
"text": [
"15-25 mm"
],
"offsets": [
[
133,
141
]
],
"normalized": []
},
{
"id": "NCT02673359_inc_T11",
"type": "Procedure",
"text": [
"transvaginal sonography (TVS)"
],
"offsets": [
[
145,
174
]
],
"normalized": []
},
{
"id": "NCT02673359_inc_T12",
"type": "Value",
"text": [
"16-24 weeks"
],
"offsets": [
[
178,
189
]
],
"normalized": []
},
{
"id": "NCT02673359_inc_T13",
"type": "Measurement",
"text": [
"gestation"
],
"offsets": [
[
193,
202
]
],
"normalized": []
},
{
"id": "NCT02673359_inc_T14",
"type": "Temporal",
"text": [
"at 16-24 weeks of gestation"
],
"offsets": [
[
175,
202
]
],
"normalized": []
},
{
"id": "NCT02673359_inc_T15",
"type": "Reference_point",
"text": [
"16-24 weeks of gestation"
],
"offsets": [
[
178,
202
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02673359_inc_R1",
"type": "Has_temporal",
"arg1_id": "NCT02673359_inc_T6",
"arg2_id": "NCT02673359_inc_T5",
"normalized": []
},
{
"id": "NCT02673359_inc_R2",
"type": "Has_scope",
"arg1_id": "NCT02673359_inc_T8",
"arg2_id": "NCT02673359_inc_T7",
"normalized": []
},
{
"id": "NCT02673359_inc_R3",
"type": "Has_value",
"arg1_id": "NCT02673359_inc_T13",
"arg2_id": "NCT02673359_inc_T12",
"normalized": []
},
{
"id": "NCT02673359_inc_R5",
"type": "Has_index",
"arg1_id": "NCT02673359_inc_T14",
"arg2_id": "NCT02673359_inc_T15",
"normalized": []
},
{
"id": "NCT02673359_inc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02673359_inc_T11",
"arg2_id": "NCT02673359_inc_T14",
"normalized": []
},
{
"id": "NCT02673359_inc_R7",
"type": "Has_value",
"arg1_id": "NCT02673359_inc_T9",
"arg2_id": "NCT02673359_inc_T10",
"normalized": []
},
{
"id": "NCT02673359_inc_R8",
"type": "AND",
"arg1_id": "NCT02673359_inc_T9",
"arg2_id": "NCT02673359_inc_T11",
"normalized": []
}
] |
NCT02675153_exc
|
NCT02675153
|
[
{
"id": "NCT02675153_exc_text",
"type": "exclusion",
"text": [
"Allergic to sirolimus or serious side effects\nNeed emergency surgery\nAccompanied with other severe disease (involve C.diff infection)\nFollow-up less than 1 year\n"
],
"offsets": [
[
0,
161
]
]
}
] |
[
{
"id": "NCT02675153_exc_T1",
"type": "Condition",
"text": [
"Allergic"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "NCT02675153_exc_T2",
"type": "Drug",
"text": [
"sirolimus"
],
"offsets": [
[
12,
21
]
],
"normalized": []
},
{
"id": "NCT02675153_exc_T3",
"type": "Qualifier",
"text": [
"serious"
],
"offsets": [
[
25,
32
]
],
"normalized": []
},
{
"id": "NCT02675153_exc_T4",
"type": "Condition",
"text": [
"side effects"
],
"offsets": [
[
33,
45
]
],
"normalized": []
},
{
"id": "NCT02675153_exc_T5",
"type": "Mood",
"text": [
"Need"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "NCT02675153_exc_T6",
"type": "Temporal",
"text": [
"less than 1 year"
],
"offsets": [
[
144,
160
]
],
"normalized": []
},
{
"id": "NCT02675153_exc_T7",
"type": "Measurement",
"text": [
"Follow-up"
],
"offsets": [
[
134,
143
]
],
"normalized": []
},
{
"id": "NCT02675153_exc_T8",
"type": "Procedure",
"text": [
"emergency surgery"
],
"offsets": [
[
51,
68
]
],
"normalized": []
},
{
"id": "NCT02675153_exc_T9",
"type": "Condition",
"text": [
"severe disease"
],
"offsets": [
[
92,
106
]
],
"normalized": []
},
{
"id": "NCT02675153_exc_T10",
"type": "Condition",
"text": [
"C.diff infection"
],
"offsets": [
[
116,
132
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02675153_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02675153_exc_T4",
"arg2_id": "NCT02675153_exc_T3",
"normalized": []
},
{
"id": "NCT02675153_exc_R2",
"type": "AND",
"arg1_id": "NCT02675153_exc_T1",
"arg2_id": "NCT02675153_exc_T2",
"normalized": []
},
{
"id": "NCT02675153_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02675153_exc_T7",
"arg2_id": "NCT02675153_exc_T6",
"normalized": []
},
{
"id": "NCT02675153_exc_R4",
"type": "Has_mood",
"arg1_id": "NCT02675153_exc_T8",
"arg2_id": "NCT02675153_exc_T5",
"normalized": []
}
] |
NCT02675153_inc
|
NCT02675153
|
[
{
"id": "NCT02675153_inc_text",
"type": "inclusion",
"text": [
"moderate to severe Crohn's Disease (basic HBI = 7) with stenosis\n"
],
"offsets": [
[
0,
65
]
]
}
] |
[
{
"id": "NCT02675153_inc_T1",
"type": "Qualifier",
"text": [
"moderate to severe"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "NCT02675153_inc_T2",
"type": "Condition",
"text": [
"Crohn's Disease"
],
"offsets": [
[
19,
34
]
],
"normalized": []
},
{
"id": "NCT02675153_inc_T3",
"type": "Measurement",
"text": [
"basic HBI"
],
"offsets": [
[
36,
45
]
],
"normalized": []
},
{
"id": "NCT02675153_inc_T4",
"type": "Value",
"text": [
"= 7"
],
"offsets": [
[
46,
49
]
],
"normalized": []
},
{
"id": "NCT02675153_inc_T5",
"type": "Condition",
"text": [
"stenosis"
],
"offsets": [
[
56,
64
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02675153_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02675153_inc_T3",
"arg2_id": "NCT02675153_inc_T4",
"normalized": []
},
{
"id": "NCT02675153_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02675153_inc_T2",
"arg2_id": "NCT02675153_inc_T1",
"normalized": []
},
{
"id": "NCT02675153_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT02675153_inc_T1",
"arg2_id": "NCT02675153_inc_T3",
"normalized": []
},
{
"id": "NCT02675153_inc_R4",
"type": "AND",
"arg1_id": "NCT02675153_inc_T2",
"arg2_id": "NCT02675153_inc_T5",
"normalized": []
}
] |
NCT02678377_exc
|
NCT02678377
|
[
{
"id": "NCT02678377_exc_text",
"type": "exclusion",
"text": [
"History of recurrent UTI (defined as three culture proven UTIs within last 12 months)\nSystemic neuromuscular disease known to affect the lower urinary tract\nUndergoing concomitant prolapse surgery\nPrevious incontinence surgery\nTreatment with anticholinergic medication in the last 2 months\nPrevious bladder injection with onabotulinumtoxinA\nPrisoner Status\nPregnancy\n"
],
"offsets": [
[
0,
367
]
]
}
] |
[
{
"id": "NCT02678377_exc_T1",
"type": "Condition",
"text": [
"recurrent UTI"
],
"offsets": [
[
11,
24
]
],
"normalized": []
},
{
"id": "NCT02678377_exc_T2",
"type": "Multiplier",
"text": [
"three"
],
"offsets": [
[
37,
42
]
],
"normalized": []
},
{
"id": "NCT02678377_exc_T3",
"type": "Measurement",
"text": [
"culture"
],
"offsets": [
[
43,
50
]
],
"normalized": []
},
{
"id": "NCT02678377_exc_T4",
"type": "Temporal",
"text": [
"within last 12 months"
],
"offsets": [
[
63,
84
]
],
"normalized": []
},
{
"id": "NCT02678377_exc_T5",
"type": "Condition",
"text": [
"neuromuscular disease"
],
"offsets": [
[
95,
116
]
],
"normalized": []
},
{
"id": "NCT02678377_exc_T6",
"type": "Procedure",
"text": [
"prolapse surgery"
],
"offsets": [
[
180,
196
]
],
"normalized": []
},
{
"id": "NCT02678377_exc_T7",
"type": "Procedure",
"text": [
"incontinence surgery"
],
"offsets": [
[
206,
226
]
],
"normalized": []
},
{
"id": "NCT02678377_exc_T8",
"type": "Drug",
"text": [
"anticholinergic medication"
],
"offsets": [
[
242,
268
]
],
"normalized": []
},
{
"id": "NCT02678377_exc_T9",
"type": "Temporal",
"text": [
"last 2 month"
],
"offsets": [
[
276,
288
]
],
"normalized": []
},
{
"id": "NCT02678377_exc_T10",
"type": "Qualifier",
"text": [
"bladder injection"
],
"offsets": [
[
299,
316
]
],
"normalized": []
},
{
"id": "NCT02678377_exc_T11",
"type": "Drug",
"text": [
"onabotulinumtoxinA"
],
"offsets": [
[
322,
340
]
],
"normalized": []
},
{
"id": "NCT02678377_exc_T12",
"type": "Person",
"text": [
"Prisoner"
],
"offsets": [
[
341,
349
]
],
"normalized": []
},
{
"id": "NCT02678377_exc_T13",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
357,
366
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02678377_exc_R1",
"type": "Has_multiplier",
"arg1_id": "NCT02678377_exc_T3",
"arg2_id": "NCT02678377_exc_T2",
"normalized": []
},
{
"id": "NCT02678377_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02678377_exc_T1",
"arg2_id": "NCT02678377_exc_T4",
"normalized": []
},
{
"id": "NCT02678377_exc_R3",
"type": "AND",
"arg1_id": "NCT02678377_exc_T1",
"arg2_id": "NCT02678377_exc_T3",
"normalized": []
},
{
"id": "NCT02678377_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02678377_exc_T8",
"arg2_id": "NCT02678377_exc_T9",
"normalized": []
},
{
"id": "NCT02678377_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02678377_exc_T11",
"arg2_id": "NCT02678377_exc_T10",
"normalized": []
}
] |
NCT02678377_inc
|
NCT02678377
|
[
{
"id": "NCT02678377_inc_text",
"type": "inclusion",
"text": [
"Undergoing mid-urethral sling surgery\nHave symptoms of both stress and urgency urinary incontinence\nAble to consent, fill out study documents, and complete all study procedures and follow-up visits\nAt least 18 years of age\nEnglish speaking\nBe able and willing to learn clean intermittent self catheterization technique\n"
],
"offsets": [
[
0,
319
]
]
}
] |
[
{
"id": "NCT02678377_inc_T1",
"type": "Procedure",
"text": [
"mid-urethral sling surgery"
],
"offsets": [
[
11,
37
]
],
"normalized": []
},
{
"id": "NCT02678377_inc_T2",
"type": "Condition",
"text": [
"urgency urinary incontinence"
],
"offsets": [
[
71,
99
]
],
"normalized": []
},
{
"id": "NCT02678377_inc_T3",
"type": "Condition",
"text": [
"tress",
"rinary incontinence"
],
"offsets": [
[
61,
66
],
[
80,
99
]
],
"normalized": []
},
{
"id": "NCT02678377_inc_T5",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
219,
222
]
],
"normalized": []
},
{
"id": "NCT02678377_inc_T6",
"type": "Value",
"text": [
"At least 18 years"
],
"offsets": [
[
198,
215
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02678377_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02678377_inc_T5",
"arg2_id": "NCT02678377_inc_T6",
"normalized": []
}
] |
NCT02678663_exc
|
NCT02678663
|
[
{
"id": "NCT02678663_exc_text",
"type": "exclusion",
"text": [
"Anticoagulant therapy during the past 1 week of the procedure \nKnown coagulopathy \nHistory of liver cirrhosis, chronic kidney disease, malignancy, inflammatory bowel disease, significant infectious disease, polyposis syndrome \n \n"
],
"offsets": [
[
0,
238
]
]
}
] |
[
{
"id": "NCT02678663_exc_T1",
"type": "Drug",
"text": [
"Anticoagulant"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "NCT02678663_exc_T2",
"type": "Temporal",
"text": [
"during the past 1 week"
],
"offsets": [
[
22,
44
]
],
"normalized": []
},
{
"id": "NCT02678663_exc_T3",
"type": "Procedure",
"text": [
"procedure"
],
"offsets": [
[
52,
61
]
],
"normalized": []
},
{
"id": "NCT02678663_exc_T4",
"type": "Reference_point",
"text": [
"procedure"
],
"offsets": [
[
52,
61
]
],
"normalized": []
},
{
"id": "NCT02678663_exc_T5",
"type": "Condition",
"text": [
"coagulopathy"
],
"offsets": [
[
69,
81
]
],
"normalized": []
},
{
"id": "NCT02678663_exc_T6",
"type": "Condition",
"text": [
"liver cirrhosis"
],
"offsets": [
[
94,
109
]
],
"normalized": []
},
{
"id": "NCT02678663_exc_T7",
"type": "Condition",
"text": [
"chronic kidney disease"
],
"offsets": [
[
111,
133
]
],
"normalized": []
},
{
"id": "NCT02678663_exc_T8",
"type": "Condition",
"text": [
"malignancy"
],
"offsets": [
[
135,
145
]
],
"normalized": []
},
{
"id": "NCT02678663_exc_T9",
"type": "Condition",
"text": [
"inflammatory bowel disease"
],
"offsets": [
[
147,
173
]
],
"normalized": []
},
{
"id": "NCT02678663_exc_T10",
"type": "Condition",
"text": [
"significant infectious disease"
],
"offsets": [
[
175,
205
]
],
"normalized": []
},
{
"id": "NCT02678663_exc_T11",
"type": "Condition",
"text": [
"polyposis syndrome"
],
"offsets": [
[
207,
225
]
],
"normalized": []
},
{
"id": "NCT02678663_exc_T12",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
83,
90
]
],
"normalized": []
},
{
"id": "NCT02678663_exc_T13",
"type": "Scope",
"text": [
"liver cirrhosis, chronic kidney disease, malignancy, inflammatory bowel disease, significant infectious disease, polyposis syndrome"
],
"offsets": [
[
94,
225
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02678663_exc_R1",
"type": "Has_index",
"arg1_id": "NCT02678663_exc_T2",
"arg2_id": "NCT02678663_exc_T4",
"normalized": []
},
{
"id": "NCT02678663_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02678663_exc_T1",
"arg2_id": "NCT02678663_exc_T2",
"normalized": []
},
{
"id": "NCT02678663_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02678663_exc_T13",
"arg2_id": "NCT02678663_exc_T12",
"normalized": []
}
] |
NCT02678663_inc
|
NCT02678663
|
[
{
"id": "NCT02678663_inc_text",
"type": "inclusion",
"text": [
"Subjects over the age of 18 years who agree informed consent and who have at least one polyp of eligible size (6-10mm) \n"
],
"offsets": [
[
0,
120
]
]
}
] |
[
{
"id": "NCT02678663_inc_T1",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "NCT02678663_inc_T2",
"type": "Value",
"text": [
"18 years",
"over"
],
"offsets": [
[
25,
33
],
[
9,
13
]
],
"normalized": []
},
{
"id": "NCT02678663_inc_T5",
"type": "Multiplier",
"text": [
"at least one"
],
"offsets": [
[
74,
86
]
],
"normalized": []
},
{
"id": "NCT02678663_inc_T6",
"type": "Condition",
"text": [
"polyp"
],
"offsets": [
[
87,
92
]
],
"normalized": []
},
{
"id": "NCT02678663_inc_T7",
"type": "Qualifier",
"text": [
"eligible size"
],
"offsets": [
[
96,
109
]
],
"normalized": []
},
{
"id": "NCT02678663_inc_T9",
"type": "Value",
"text": [
"6-10mm"
],
"offsets": [
[
111,
117
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02678663_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02678663_inc_T1",
"arg2_id": "NCT02678663_inc_T2",
"normalized": []
},
{
"id": "NCT02678663_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02678663_inc_T6",
"arg2_id": "NCT02678663_inc_T7",
"normalized": []
},
{
"id": "NCT02678663_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT02678663_inc_T7",
"arg2_id": "NCT02678663_inc_T9",
"normalized": []
},
{
"id": "NCT02678663_inc_R4",
"type": "Has_multiplier",
"arg1_id": "NCT02678663_inc_T6",
"arg2_id": "NCT02678663_inc_T5",
"normalized": []
}
] |
NCT02678728_exc
|
NCT02678728
|
[
{
"id": "NCT02678728_exc_text",
"type": "exclusion",
"text": [
"Unstable vital sign before surgery\nSevere pulmonary disease requiring consistent treatment\nIlliterate\nPregnancy\n"
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "NCT02678728_exc_T1",
"type": "Qualifier",
"text": [
"Unstable"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "NCT02678728_exc_T2",
"type": "Condition",
"text": [
"vital sign"
],
"offsets": [
[
9,
19
]
],
"normalized": []
},
{
"id": "NCT02678728_exc_T3",
"type": "Temporal",
"text": [
"before surgery"
],
"offsets": [
[
20,
34
]
],
"normalized": []
},
{
"id": "NCT02678728_exc_T4",
"type": "Procedure",
"text": [
"surgery"
],
"offsets": [
[
27,
34
]
],
"normalized": []
},
{
"id": "NCT02678728_exc_T5",
"type": "Reference_point",
"text": [
"surgery"
],
"offsets": [
[
27,
34
]
],
"normalized": []
},
{
"id": "NCT02678728_exc_T6",
"type": "Condition",
"text": [
"pulmonary disease"
],
"offsets": [
[
42,
59
]
],
"normalized": []
},
{
"id": "NCT02678728_exc_T7",
"type": "Procedure",
"text": [
"consistent treatment"
],
"offsets": [
[
70,
90
]
],
"normalized": []
},
{
"id": "NCT02678728_exc_T8",
"type": "Mood",
"text": [
"requiring"
],
"offsets": [
[
60,
69
]
],
"normalized": []
},
{
"id": "NCT02678728_exc_T9",
"type": "Qualifier",
"text": [
"Severe"
],
"offsets": [
[
35,
41
]
],
"normalized": []
},
{
"id": "NCT02678728_exc_T10",
"type": "Observation",
"text": [
"Illiterate"
],
"offsets": [
[
91,
101
]
],
"normalized": []
},
{
"id": "NCT02678728_exc_T11",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
102,
111
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02678728_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02678728_exc_T2",
"arg2_id": "NCT02678728_exc_T1",
"normalized": []
},
{
"id": "NCT02678728_exc_R3",
"type": "Has_index",
"arg1_id": "NCT02678728_exc_T3",
"arg2_id": "NCT02678728_exc_T5",
"normalized": []
},
{
"id": "NCT02678728_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02678728_exc_T2",
"arg2_id": "NCT02678728_exc_T3",
"normalized": []
},
{
"id": "NCT02678728_exc_R5",
"type": "Has_mood",
"arg1_id": "NCT02678728_exc_T7",
"arg2_id": "NCT02678728_exc_T8",
"normalized": []
},
{
"id": "NCT02678728_exc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT02678728_exc_T6",
"arg2_id": "NCT02678728_exc_T9",
"normalized": []
},
{
"id": "NCT02678728_exc_R7",
"type": "AND",
"arg1_id": "NCT02678728_exc_T6",
"arg2_id": "NCT02678728_exc_T7",
"normalized": []
}
] |
NCT02678728_inc
|
NCT02678728
|
[
{
"id": "NCT02678728_inc_text",
"type": "inclusion",
"text": [
"Patients undergoing thoracic aorta surgery with hypothermic circulatory arrest, over 20-of age\n"
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "NCT02678728_inc_T1",
"type": "Qualifier",
"text": [
"thoracic aorta"
],
"offsets": [
[
20,
34
]
],
"normalized": []
},
{
"id": "NCT02678728_inc_T2",
"type": "Procedure",
"text": [
"surgery"
],
"offsets": [
[
35,
42
]
],
"normalized": []
},
{
"id": "NCT02678728_inc_T3",
"type": "Condition",
"text": [
"hypothermic circulatory arrest"
],
"offsets": [
[
48,
78
]
],
"normalized": []
},
{
"id": "NCT02678728_inc_T4",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
91,
94
]
],
"normalized": []
},
{
"id": "NCT02678728_inc_T5",
"type": "Value",
"text": [
"over 20"
],
"offsets": [
[
80,
87
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02678728_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02678728_inc_T2",
"arg2_id": "NCT02678728_inc_T1",
"normalized": []
},
{
"id": "NCT02678728_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02678728_inc_T4",
"arg2_id": "NCT02678728_inc_T5",
"normalized": []
},
{
"id": "NCT02678728_inc_R3",
"type": "AND",
"arg1_id": "NCT02678728_inc_T2",
"arg2_id": "NCT02678728_inc_T3",
"normalized": []
}
] |
NCT02678962_exc
|
NCT02678962
|
[
{
"id": "NCT02678962_exc_text",
"type": "exclusion",
"text": [
"Preexisting ocular diseases or conditions other than age related cataracts, have contraindications for cataract surgery;\nPreexisting systemic diseases or conditions that may confound the results of the study;\nPrevious ocular surgery history or ocular trauma that may confound the results of the study;\nRequire combined surgery that may confound the results of the study;\nPrevious participation in other clinical trial within 30 days of this study start;\nSystemic or ocular medications that may confound the outcome of the intervention\nPregnant, lactating, or planning to become pregnant during the course of the trial;\n"
],
"offsets": [
[
0,
619
]
]
}
] |
[
{
"id": "NCT02678962_exc_T1",
"type": "Condition",
"text": [
"ocular diseases"
],
"offsets": [
[
12,
27
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T2",
"type": "Temporal",
"text": [
"Preexisting"
],
"offsets": [
[
0,
11
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T3",
"type": "Condition",
"text": [
"conditions"
],
"offsets": [
[
31,
41
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T4",
"type": "Negation",
"text": [
"other than"
],
"offsets": [
[
42,
52
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T5",
"type": "Condition",
"text": [
"cataracts"
],
"offsets": [
[
65,
74
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T6",
"type": "Qualifier",
"text": [
"age related"
],
"offsets": [
[
53,
64
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T7",
"type": "Condition",
"text": [
"contraindications"
],
"offsets": [
[
81,
98
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T8",
"type": "Procedure",
"text": [
"cataract surgery"
],
"offsets": [
[
103,
119
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T9",
"type": "Temporal",
"text": [
"Preexisting"
],
"offsets": [
[
121,
132
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T10",
"type": "Condition",
"text": [
"systemic diseases"
],
"offsets": [
[
133,
150
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T11",
"type": "Condition",
"text": [
"conditions"
],
"offsets": [
[
154,
164
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T12",
"type": "Qualifier",
"text": [
"may confound the results of the study"
],
"offsets": [
[
170,
207
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T13",
"type": "Procedure",
"text": [
"ocular surgery"
],
"offsets": [
[
218,
232
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T14",
"type": "Temporal",
"text": [
"Previous"
],
"offsets": [
[
209,
217
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T15",
"type": "Condition",
"text": [
"ocular trauma"
],
"offsets": [
[
244,
257
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T16",
"type": "Qualifier",
"text": [
"may confound the results of the study"
],
"offsets": [
[
263,
300
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T17",
"type": "Scope",
"text": [
"Previous ocular surgery history or ocular trauma"
],
"offsets": [
[
209,
257
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T18",
"type": "Procedure",
"text": [
"combined surgery"
],
"offsets": [
[
310,
326
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T19",
"type": "Mood",
"text": [
"Require"
],
"offsets": [
[
302,
309
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T20",
"type": "Qualifier",
"text": [
"may confound the results of the study"
],
"offsets": [
[
332,
369
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T22",
"type": "Drug",
"text": [
"ocular medications"
],
"offsets": [
[
466,
484
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T23",
"type": "Drug",
"text": [
"mic or o",
"ations that"
],
"offsets": [
[
459,
467
],
[
478,
489
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T24",
"type": "Qualifier",
"text": [
"may confound the outcome of the intervention"
],
"offsets": [
[
490,
534
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T25",
"type": "Scope",
"text": [
"Systemic or ocular medications"
],
"offsets": [
[
454,
484
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T26",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
535,
543
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T27",
"type": "Condition",
"text": [
"lactating"
],
"offsets": [
[
545,
554
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T28",
"type": "Mood",
"text": [
"planning to become"
],
"offsets": [
[
559,
577
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T29",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
578,
586
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T30",
"type": "Temporal",
"text": [
"during the course of the trial"
],
"offsets": [
[
587,
617
]
],
"normalized": []
},
{
"id": "NCT02678962_exc_T31",
"type": "Scope",
"text": [
"Pregnant, lactating, or planning to become pregnant"
],
"offsets": [
[
535,
586
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02678962_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02678962_exc_T5",
"arg2_id": "NCT02678962_exc_T6",
"normalized": []
},
{
"id": "NCT02678962_exc_R2",
"type": "AND",
"arg1_id": "NCT02678962_exc_T7",
"arg2_id": "NCT02678962_exc_T8",
"normalized": []
},
{
"id": "NCT02678962_exc_R3",
"type": "Has_negation",
"arg1_id": "NCT02678962_exc_T5",
"arg2_id": "NCT02678962_exc_T4",
"normalized": []
},
{
"id": "NCT02678962_exc_R4",
"type": "AND",
"arg1_id": "NCT02678962_exc_T3",
"arg2_id": "NCT02678962_exc_T5",
"normalized": []
},
{
"id": "NCT02678962_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02678962_exc_T1",
"arg2_id": "NCT02678962_exc_T2",
"normalized": []
},
{
"id": "NCT02678962_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02678962_exc_T10",
"arg2_id": "NCT02678962_exc_T9",
"normalized": []
},
{
"id": "NCT02678962_exc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02678962_exc_T11",
"arg2_id": "NCT02678962_exc_T12",
"normalized": []
},
{
"id": "NCT02678962_exc_R8",
"type": "Has_temporal",
"arg1_id": "NCT02678962_exc_T13",
"arg2_id": "NCT02678962_exc_T14",
"normalized": []
},
{
"id": "NCT02678962_exc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT02678962_exc_T17",
"arg2_id": "NCT02678962_exc_T16",
"normalized": []
},
{
"id": "NCT02678962_exc_R10",
"type": "Has_mood",
"arg1_id": "NCT02678962_exc_T18",
"arg2_id": "NCT02678962_exc_T19",
"normalized": []
},
{
"id": "NCT02678962_exc_R11",
"type": "Has_qualifier",
"arg1_id": "NCT02678962_exc_T18",
"arg2_id": "NCT02678962_exc_T20",
"normalized": []
},
{
"id": "NCT02678962_exc_R12",
"type": "Has_qualifier",
"arg1_id": "NCT02678962_exc_T25",
"arg2_id": "NCT02678962_exc_T24",
"normalized": []
},
{
"id": "NCT02678962_exc_R13",
"type": "Has_mood",
"arg1_id": "NCT02678962_exc_T29",
"arg2_id": "NCT02678962_exc_T28",
"normalized": []
},
{
"id": "NCT02678962_exc_R14",
"type": "Has_temporal",
"arg1_id": "NCT02678962_exc_T31",
"arg2_id": "NCT02678962_exc_T30",
"normalized": []
}
] |
NCT02678962_inc
|
NCT02678962
|
[
{
"id": "NCT02678962_inc_text",
"type": "inclusion",
"text": [
"Age from 40 to 80 years old, either gender;\nPatients with bilateral age related cataracts, require bilateral cataract phacoemulsification combined Intraocular Lens implantation;\nWilling to undergo second eye surgery within 7 days after first eye surgery;\nThe potential postoperative visual acuity of 20/40 or better in both eyes;\nPreoperative measurement of corneal astigmatism indicate the subjects are suitable for multifocal intraocular lenses implantation;\nCapability to understand the informed consent and willing and able to attend study\n"
],
"offsets": [
[
0,
544
]
]
}
] |
[
{
"id": "NCT02678962_inc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02678962_inc_T2",
"type": "Value",
"text": [
"from 40 to 80 years old"
],
"offsets": [
[
4,
27
]
],
"normalized": []
},
{
"id": "NCT02678962_inc_T3",
"type": "Qualifier",
"text": [
"age related"
],
"offsets": [
[
68,
79
]
],
"normalized": []
},
{
"id": "NCT02678962_inc_T4",
"type": "Condition",
"text": [
"cataracts"
],
"offsets": [
[
80,
89
]
],
"normalized": []
},
{
"id": "NCT02678962_inc_T5",
"type": "Qualifier",
"text": [
"bilateral"
],
"offsets": [
[
58,
67
]
],
"normalized": []
},
{
"id": "NCT02678962_inc_T6",
"type": "Procedure",
"text": [
"cataract phacoemulsification"
],
"offsets": [
[
109,
137
]
],
"normalized": []
},
{
"id": "NCT02678962_inc_T7",
"type": "Qualifier",
"text": [
"bilateral"
],
"offsets": [
[
99,
108
]
],
"normalized": []
},
{
"id": "NCT02678962_inc_T8",
"type": "Procedure",
"text": [
"Intraocular Lens implantation"
],
"offsets": [
[
147,
176
]
],
"normalized": []
},
{
"id": "NCT02678962_inc_T9",
"type": "Scope",
"text": [
"cataract phacoemulsification combined Intraocular Lens implantation"
],
"offsets": [
[
109,
176
]
],
"normalized": []
},
{
"id": "NCT02678962_inc_T12",
"type": "Measurement",
"text": [
"measurement of corneal astigmatism"
],
"offsets": [
[
343,
377
]
],
"normalized": []
},
{
"id": "NCT02678962_inc_T13",
"type": "Procedure",
"text": [
"multifocal intraocular lenses implantation"
],
"offsets": [
[
417,
459
]
],
"normalized": []
},
{
"id": "NCT02678962_inc_T14",
"type": "Value",
"text": [
"suitable"
],
"offsets": [
[
404,
412
]
],
"normalized": []
},
{
"id": "NCT02678962_inc_T15",
"type": "Temporal",
"text": [
"Preoperative"
],
"offsets": [
[
330,
342
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02678962_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02678962_inc_T1",
"arg2_id": "NCT02678962_inc_T2",
"normalized": []
},
{
"id": "NCT02678962_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02678962_inc_T4",
"arg2_id": "NCT02678962_inc_T3",
"normalized": []
},
{
"id": "NCT02678962_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02678962_inc_T4",
"arg2_id": "NCT02678962_inc_T5",
"normalized": []
},
{
"id": "NCT02678962_inc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02678962_inc_T9",
"arg2_id": "NCT02678962_inc_T7",
"normalized": []
},
{
"id": "NCT02678962_inc_R5",
"type": "AND",
"arg1_id": "NCT02678962_inc_T14",
"arg2_id": "NCT02678962_inc_T13",
"normalized": []
},
{
"id": "NCT02678962_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02678962_inc_T12",
"arg2_id": "NCT02678962_inc_T14",
"normalized": []
},
{
"id": "NCT02678962_inc_R7",
"type": "Has_temporal",
"arg1_id": "NCT02678962_inc_T12",
"arg2_id": "NCT02678962_inc_T15",
"normalized": []
}
] |
NCT02680054_exc
|
NCT02680054
|
[
{
"id": "NCT02680054_exc_text",
"type": "exclusion",
"text": [
"HbA1c greater than 75 mmol/mol (9.0%)\nChild unwilling to agree to second insulin injection at a meal-time\nUntreated coeliac disease or other concomitant condition likely to affect BG control\nFood allergies (other than controlled Coeliac Disease)\nVegetarians, vegans or patients with religious dietary restrictions (as the standard meal contains meat)\nParticipant taking any glucose-containing medication concurrently\n"
],
"offsets": [
[
0,
417
]
]
}
] |
[
{
"id": "NCT02680054_exc_T1",
"type": "Measurement",
"text": [
"HbA1c"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02680054_exc_T2",
"type": "Value",
"text": [
"greater than 75 mmol/mol"
],
"offsets": [
[
6,
30
]
],
"normalized": []
},
{
"id": "NCT02680054_exc_T3",
"type": "Value",
"text": [
"9.0%"
],
"offsets": [
[
32,
36
]
],
"normalized": []
},
{
"id": "NCT02680054_exc_T5",
"type": "Condition",
"text": [
"coeliac disease"
],
"offsets": [
[
116,
131
]
],
"normalized": []
},
{
"id": "NCT02680054_exc_T6",
"type": "Qualifier",
"text": [
"Untreated"
],
"offsets": [
[
106,
115
]
],
"normalized": []
},
{
"id": "NCT02680054_exc_T7",
"type": "Condition",
"text": [
"Food allergies"
],
"offsets": [
[
191,
205
]
],
"normalized": []
},
{
"id": "NCT02680054_exc_T8",
"type": "Negation",
"text": [
"other"
],
"offsets": [
[
207,
212
]
],
"normalized": []
},
{
"id": "NCT02680054_exc_T9",
"type": "Condition",
"text": [
"Coeliac Disease"
],
"offsets": [
[
229,
244
]
],
"normalized": []
},
{
"id": "NCT02680054_exc_T10",
"type": "Person",
"text": [
"Vegetarians"
],
"offsets": [
[
246,
257
]
],
"normalized": []
},
{
"id": "NCT02680054_exc_T11",
"type": "Procedure",
"text": [
"glucose-containing medication"
],
"offsets": [
[
374,
403
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02680054_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT02680054_exc_T2",
"arg2_id": "NCT02680054_exc_T3",
"normalized": []
},
{
"id": "NCT02680054_exc_R2",
"type": "Has_value",
"arg1_id": "NCT02680054_exc_T1",
"arg2_id": "NCT02680054_exc_T2",
"normalized": []
},
{
"id": "NCT02680054_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02680054_exc_T5",
"arg2_id": "NCT02680054_exc_T6",
"normalized": []
},
{
"id": "NCT02680054_exc_R4",
"type": "Has_negation",
"arg1_id": "NCT02680054_exc_T9",
"arg2_id": "NCT02680054_exc_T8",
"normalized": []
}
] |
NCT02680054_inc
|
NCT02680054
|
[
{
"id": "NCT02680054_inc_text",
"type": "inclusion",
"text": [
"Diagnosis of Type 1 diabetes (for at least a year)\nOn multiple daily insulin injections, including basal long-acting insulin and rapid-acting insulin before each meal.\nHbA1c < 75 mmol/mol (9.0%)\nParticipant and/or parent/legal guardian willing and able to give informed consent for participation in the study.\nFamily have a freezer in which to safely store the test meals.\nIn the Investigator's opinion, is able and willing to comply with all trial requirements.\n"
],
"offsets": [
[
0,
463
]
]
}
] |
[
{
"id": "NCT02680054_inc_T1",
"type": "Condition",
"text": [
"Type 1 diabetes"
],
"offsets": [
[
13,
28
]
],
"normalized": []
},
{
"id": "NCT02680054_inc_T2",
"type": "Temporal",
"text": [
"at least a year"
],
"offsets": [
[
34,
49
]
],
"normalized": []
},
{
"id": "NCT02680054_inc_T3",
"type": "Drug",
"text": [
"insulin"
],
"offsets": [
[
69,
76
]
],
"normalized": []
},
{
"id": "NCT02680054_inc_T4",
"type": "Qualifier",
"text": [
"daily"
],
"offsets": [
[
63,
68
]
],
"normalized": []
},
{
"id": "NCT02680054_inc_T5",
"type": "Drug",
"text": [
"insulin"
],
"offsets": [
[
117,
124
]
],
"normalized": []
},
{
"id": "NCT02680054_inc_T6",
"type": "Drug",
"text": [
"insulin"
],
"offsets": [
[
142,
149
]
],
"normalized": []
},
{
"id": "NCT02680054_inc_T7",
"type": "Qualifier",
"text": [
"rapid-acting"
],
"offsets": [
[
129,
141
]
],
"normalized": []
},
{
"id": "NCT02680054_inc_T8",
"type": "Qualifier",
"text": [
"basal long-acting"
],
"offsets": [
[
99,
116
]
],
"normalized": []
},
{
"id": "NCT02680054_inc_T9",
"type": "Scope",
"text": [
"basal long-acting insulin and rapid-acting insulin"
],
"offsets": [
[
99,
149
]
],
"normalized": []
},
{
"id": "NCT02680054_inc_T10",
"type": "Measurement",
"text": [
"HbA1c"
],
"offsets": [
[
168,
173
]
],
"normalized": []
},
{
"id": "NCT02680054_inc_T11",
"type": "Value",
"text": [
"< 75 mmol/mol"
],
"offsets": [
[
174,
187
]
],
"normalized": []
},
{
"id": "NCT02680054_inc_T12",
"type": "Value",
"text": [
"9.0%"
],
"offsets": [
[
189,
193
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02680054_inc_R1",
"type": "Has_temporal",
"arg1_id": "NCT02680054_inc_T1",
"arg2_id": "NCT02680054_inc_T2",
"normalized": []
},
{
"id": "NCT02680054_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02680054_inc_T3",
"arg2_id": "NCT02680054_inc_T4",
"normalized": []
},
{
"id": "NCT02680054_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02680054_inc_T5",
"arg2_id": "NCT02680054_inc_T8",
"normalized": []
},
{
"id": "NCT02680054_inc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02680054_inc_T6",
"arg2_id": "NCT02680054_inc_T7",
"normalized": []
},
{
"id": "NCT02680054_inc_R5",
"type": "Subsumes",
"arg1_id": "NCT02680054_inc_T3",
"arg2_id": "NCT02680054_inc_T9",
"normalized": []
},
{
"id": "NCT02680054_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02680054_inc_T10",
"arg2_id": "NCT02680054_inc_T11",
"normalized": []
},
{
"id": "NCT02680054_inc_R7",
"type": "Subsumes",
"arg1_id": "NCT02680054_inc_T11",
"arg2_id": "NCT02680054_inc_T12",
"normalized": []
}
] |
NCT02686021_exc
|
NCT02686021
|
[
{
"id": "NCT02686021_exc_text",
"type": "exclusion",
"text": [
"simultaneous both sided extraction or only upper third molar extraction\ngeneral anesthesia\nknown or presumed abnormal coagulation status\nknown or presumed liver or renal dysfunction\ncontraindication against metamizole known or suspected (known or suspected allergy against novalgin or other pyrazolones, anaphylactic reaction against NSAIDS, decreased bone marrow function or hematopoesis, hepatic porphyria, glucose-6-phosphate dehydrogenase deficiency, and pregnancy/breastfeeding)\ncontraindication against ibuprofen (known or suspected allergy against ibuprofen, anaphylactic reaction against Nonsteroidal anti-inflammatory drugs (NSAID), active or recurrent stomach or duodenal ulcera or bleeding, severe liver or renal insufficiency, inflammatory bowel syndrome, and pregnancy/breastfeeding)\npregnancy and breast feeding mothers\n"
],
"offsets": [
[
0,
834
]
]
}
] |
[
{
"id": "NCT02686021_exc_T1",
"type": "Temporal",
"text": [
"simultaneous"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T2",
"type": "Qualifier",
"text": [
"both sided"
],
"offsets": [
[
13,
23
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T3",
"type": "Procedure",
"text": [
"molar extraction"
],
"offsets": [
[
55,
71
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T4",
"type": "Qualifier",
"text": [
"only upper third"
],
"offsets": [
[
38,
54
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T5",
"type": "Scope",
"text": [
"both sided extraction or only upper third"
],
"offsets": [
[
13,
54
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T6",
"type": "Procedure",
"text": [
"general anesthesia"
],
"offsets": [
[
72,
90
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T7",
"type": "Condition",
"text": [
"abnormal coagulation status"
],
"offsets": [
[
109,
136
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T8",
"type": "Qualifier",
"text": [
"presumed"
],
"offsets": [
[
100,
108
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T9",
"type": "Qualifier",
"text": [
"known"
],
"offsets": [
[
91,
96
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T10",
"type": "Scope",
"text": [
"known or presumed"
],
"offsets": [
[
91,
108
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T11",
"type": "Qualifier",
"text": [
"known"
],
"offsets": [
[
137,
142
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T12",
"type": "Qualifier",
"text": [
"presumed"
],
"offsets": [
[
146,
154
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T13",
"type": "Scope",
"text": [
"known or presumed"
],
"offsets": [
[
137,
154
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T14",
"type": "Condition",
"text": [
"renal dysfunction"
],
"offsets": [
[
164,
181
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T15",
"type": "Condition",
"text": [
"er or",
"function\nco"
],
"offsets": [
[
158,
163
],
[
173,
184
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T16",
"type": "Scope",
"text": [
"liver or renal dysfunction"
],
"offsets": [
[
155,
181
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T17",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
182,
198
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T18",
"type": "Drug",
"text": [
"metamizole"
],
"offsets": [
[
207,
217
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T19",
"type": "Qualifier",
"text": [
"known"
],
"offsets": [
[
218,
223
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T20",
"type": "Qualifier",
"text": [
"suspected"
],
"offsets": [
[
227,
236
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T21",
"type": "Scope",
"text": [
"known or suspected"
],
"offsets": [
[
218,
236
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T22",
"type": "Qualifier",
"text": [
"known"
],
"offsets": [
[
238,
243
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T23",
"type": "Qualifier",
"text": [
"suspected"
],
"offsets": [
[
247,
256
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T24",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
257,
264
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T25",
"type": "Drug",
"text": [
"novalgin"
],
"offsets": [
[
273,
281
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T26",
"type": "Drug",
"text": [
"pyrazolones"
],
"offsets": [
[
291,
302
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T27",
"type": "Qualifier",
"text": [
"other"
],
"offsets": [
[
285,
290
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T28",
"type": "Condition",
"text": [
"anaphylactic reaction"
],
"offsets": [
[
304,
325
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T29",
"type": "Drug",
"text": [
"NSAIDS"
],
"offsets": [
[
334,
340
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T30",
"type": "Measurement",
"text": [
"bone marrow function"
],
"offsets": [
[
352,
372
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T31",
"type": "Value",
"text": [
"decreased"
],
"offsets": [
[
342,
351
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T32",
"type": "Measurement",
"text": [
"hematopoesis"
],
"offsets": [
[
376,
388
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T33",
"type": "Scope",
"text": [
"bone marrow function or hematopoesis"
],
"offsets": [
[
352,
388
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T34",
"type": "Condition",
"text": [
"hepatic porphyria"
],
"offsets": [
[
390,
407
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T35",
"type": "Condition",
"text": [
"glucose-6-phosphate dehydrogenase deficiency"
],
"offsets": [
[
409,
453
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T36",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
459,
468
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T37",
"type": "Observation",
"text": [
"breastfeeding"
],
"offsets": [
[
469,
482
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T38",
"type": "Scope",
"text": [
"novalgin or other pyrazolones"
],
"offsets": [
[
273,
302
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T39",
"type": "Scope",
"text": [
"known or suspected"
],
"offsets": [
[
238,
256
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T40",
"type": "Scope",
"text": [
"known or suspected allergy against novalgin or other pyrazolones, anaphylactic reaction against NSAIDS, decreased bone marrow function or hematopoesis, hepatic porphyria, glucose-6-phosphate dehydrogenase deficiency, and pregnancy/breastfeeding"
],
"offsets": [
[
238,
482
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T41",
"type": "Scope",
"text": [
"contraindication against metamizole known or suspected"
],
"offsets": [
[
182,
236
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T42",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
484,
500
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T43",
"type": "Drug",
"text": [
"ibuprofen"
],
"offsets": [
[
509,
518
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T44",
"type": "Qualifier",
"text": [
"known"
],
"offsets": [
[
520,
525
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T45",
"type": "Qualifier",
"text": [
"suspected"
],
"offsets": [
[
529,
538
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T46",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
539,
546
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T47",
"type": "Drug",
"text": [
"ibuprofen"
],
"offsets": [
[
555,
564
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T48",
"type": "Scope",
"text": [
"known or suspected"
],
"offsets": [
[
520,
538
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T49",
"type": "Condition",
"text": [
"anaphylactic reaction"
],
"offsets": [
[
566,
587
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T50",
"type": "Drug",
"text": [
"Nonsteroidal anti-inflammatory drugs (NSAID)"
],
"offsets": [
[
596,
640
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T51",
"type": "Temporal",
"text": [
"active"
],
"offsets": [
[
642,
648
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T52",
"type": "Qualifier",
"text": [
"recurrent"
],
"offsets": [
[
652,
661
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T53",
"type": "Qualifier",
"text": [
"stomach"
],
"offsets": [
[
662,
669
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T54",
"type": "Condition",
"text": [
"bleeding"
],
"offsets": [
[
692,
700
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T55",
"type": "Qualifier",
"text": [
"duodenal"
],
"offsets": [
[
673,
681
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T56",
"type": "Condition",
"text": [
"ulcera"
],
"offsets": [
[
682,
688
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T57",
"type": "Scope",
"text": [
"ulcera or bleeding"
],
"offsets": [
[
682,
700
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T58",
"type": "Scope",
"text": [
"stomach or duodenal"
],
"offsets": [
[
662,
681
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T59",
"type": "Scope",
"text": [
"active or recurrent"
],
"offsets": [
[
642,
661
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T60",
"type": "Condition",
"text": [
"e liver or r",
"ficiency, inf"
],
"offsets": [
[
707,
719
],
[
729,
742
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T61",
"type": "Condition",
"text": [
"e live",
" insufficiency, in"
],
"offsets": [
[
707,
713
],
[
723,
741
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T62",
"type": "Condition",
"text": [
"inflammatory bowel syndrome"
],
"offsets": [
[
739,
766
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T63",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
772,
781
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T64",
"type": "Observation",
"text": [
"breastfeeding"
],
"offsets": [
[
782,
795
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T65",
"type": "Scope",
"text": [
"known or suspected allergy against ibuprofen, anaphylactic reaction against Nonsteroidal anti-inflammatory drugs (NSAID), active or recurrent stomach or duodenal ulcera or bleeding, severe liver or renal insufficiency, inflammatory bowel syndrome, and pregnancy/breastfeeding"
],
"offsets": [
[
520,
795
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T66",
"type": "Scope",
"text": [
"contraindication against ibuprofen"
],
"offsets": [
[
484,
518
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T67",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
797,
806
]
],
"normalized": []
},
{
"id": "NCT02686021_exc_T68",
"type": "Observation",
"text": [
"breast feeding"
],
"offsets": [
[
811,
825
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02686021_exc_R1",
"type": "Has_scope",
"arg1_id": "NCT02686021_exc_T3",
"arg2_id": "NCT02686021_exc_T5",
"normalized": []
},
{
"id": "NCT02686021_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02686021_exc_T3",
"arg2_id": "NCT02686021_exc_T1",
"normalized": []
},
{
"id": "NCT02686021_exc_R3",
"type": "Has_scope",
"arg1_id": "NCT02686021_exc_T7",
"arg2_id": "NCT02686021_exc_T10",
"normalized": []
},
{
"id": "NCT02686021_exc_R4",
"type": "Has_scope",
"arg1_id": "NCT02686021_exc_T16",
"arg2_id": "NCT02686021_exc_T13",
"normalized": []
},
{
"id": "NCT02686021_exc_R5",
"type": "AND",
"arg1_id": "NCT02686021_exc_T17",
"arg2_id": "NCT02686021_exc_T18",
"normalized": []
},
{
"id": "NCT02686021_exc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT02686021_exc_T26",
"arg2_id": "NCT02686021_exc_T27",
"normalized": []
},
{
"id": "NCT02686021_exc_R7",
"type": "Has_value",
"arg1_id": "NCT02686021_exc_T33",
"arg2_id": "NCT02686021_exc_T31",
"normalized": []
},
{
"id": "NCT02686021_exc_R8",
"type": "AND",
"arg1_id": "NCT02686021_exc_T28",
"arg2_id": "NCT02686021_exc_T29",
"normalized": []
},
{
"id": "NCT02686021_exc_R9",
"type": "Has_scope",
"arg1_id": "NCT02686021_exc_T24",
"arg2_id": "NCT02686021_exc_T38",
"normalized": []
},
{
"id": "NCT02686021_exc_R10",
"type": "Has_scope",
"arg1_id": "NCT02686021_exc_T24",
"arg2_id": "NCT02686021_exc_T39",
"normalized": []
},
{
"id": "NCT02686021_exc_R11",
"type": "Has_scope",
"arg1_id": "NCT02686021_exc_T17",
"arg2_id": "NCT02686021_exc_T21",
"normalized": []
},
{
"id": "NCT02686021_exc_R12",
"type": "Subsumes",
"arg1_id": "NCT02686021_exc_T41",
"arg2_id": "NCT02686021_exc_T40",
"normalized": []
},
{
"id": "NCT02686021_exc_R13",
"type": "AND",
"arg1_id": "NCT02686021_exc_T42",
"arg2_id": "NCT02686021_exc_T43",
"normalized": []
},
{
"id": "NCT02686021_exc_R14",
"type": "Has_scope",
"arg1_id": "NCT02686021_exc_T46",
"arg2_id": "NCT02686021_exc_T48",
"normalized": []
},
{
"id": "NCT02686021_exc_R15",
"type": "AND",
"arg1_id": "NCT02686021_exc_T46",
"arg2_id": "NCT02686021_exc_T47",
"normalized": []
},
{
"id": "NCT02686021_exc_R16",
"type": "AND",
"arg1_id": "NCT02686021_exc_T49",
"arg2_id": "NCT02686021_exc_T50",
"normalized": []
},
{
"id": "NCT02686021_exc_R17",
"type": "Has_scope",
"arg1_id": "NCT02686021_exc_T57",
"arg2_id": "NCT02686021_exc_T58",
"normalized": []
},
{
"id": "NCT02686021_exc_R18",
"type": "Has_scope",
"arg1_id": "NCT02686021_exc_T57",
"arg2_id": "NCT02686021_exc_T59",
"normalized": []
},
{
"id": "NCT02686021_exc_R19",
"type": "Subsumes",
"arg1_id": "NCT02686021_exc_T66",
"arg2_id": "NCT02686021_exc_T65",
"normalized": []
}
] |
NCT02686021_inc
|
NCT02686021
|
[
{
"id": "NCT02686021_inc_text",
"type": "inclusion",
"text": [
"planned sequential both-sided lower third molar extraction (split-mouth) with osteotomy (with or without upper molar extraction in local anesthesia)\nable to understand the study and the NRS scale\n"
],
"offsets": [
[
0,
196
]
]
}
] |
[
{
"id": "NCT02686021_inc_T1",
"type": "Mood",
"text": [
"planned"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "NCT02686021_inc_T2",
"type": "Qualifier",
"text": [
"sequential"
],
"offsets": [
[
8,
18
]
],
"normalized": []
},
{
"id": "NCT02686021_inc_T3",
"type": "Qualifier",
"text": [
"both-sided"
],
"offsets": [
[
19,
29
]
],
"normalized": []
},
{
"id": "NCT02686021_inc_T4",
"type": "Procedure",
"text": [
"lower third molar extraction"
],
"offsets": [
[
30,
58
]
],
"normalized": []
},
{
"id": "NCT02686021_inc_T5",
"type": "Qualifier",
"text": [
"split-mouth"
],
"offsets": [
[
60,
71
]
],
"normalized": []
},
{
"id": "NCT02686021_inc_T6",
"type": "Procedure",
"text": [
"osteotomy"
],
"offsets": [
[
78,
87
]
],
"normalized": []
},
{
"id": "NCT02686021_inc_T7",
"type": "Procedure",
"text": [
"upper molar extraction"
],
"offsets": [
[
105,
127
]
],
"normalized": []
},
{
"id": "NCT02686021_inc_T8",
"type": "Procedure",
"text": [
"local anesthesia"
],
"offsets": [
[
131,
147
]
],
"normalized": []
},
{
"id": "NCT02686021_inc_T9",
"type": "Scope",
"text": [
"upper molar extraction in local anesthesia"
],
"offsets": [
[
105,
147
]
],
"normalized": []
},
{
"id": "NCT02686021_inc_T10",
"type": "Observation",
"text": [
"able to understand the study"
],
"offsets": [
[
149,
177
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02686021_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02686021_inc_T4",
"arg2_id": "NCT02686021_inc_T3",
"normalized": []
},
{
"id": "NCT02686021_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02686021_inc_T4",
"arg2_id": "NCT02686021_inc_T2",
"normalized": []
},
{
"id": "NCT02686021_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02686021_inc_T4",
"arg2_id": "NCT02686021_inc_T5",
"normalized": []
},
{
"id": "NCT02686021_inc_R4",
"type": "AND",
"arg1_id": "NCT02686021_inc_T4",
"arg2_id": "NCT02686021_inc_T6",
"normalized": []
},
{
"id": "NCT02686021_inc_R5",
"type": "AND",
"arg1_id": "NCT02686021_inc_T7",
"arg2_id": "NCT02686021_inc_T8",
"normalized": []
},
{
"id": "NCT02686021_inc_R6",
"type": "Has_scope",
"arg1_id": "NCT02686021_inc_T4",
"arg2_id": "NCT02686021_inc_T9",
"normalized": []
},
{
"id": "NCT02686021_inc_R7",
"type": "Has_mood",
"arg1_id": "NCT02686021_inc_T4",
"arg2_id": "NCT02686021_inc_T1",
"normalized": []
}
] |
NCT02687178_exc
|
NCT02687178
|
[
{
"id": "NCT02687178_exc_text",
"type": "exclusion",
"text": [
"diabetes mellitus \nsecondary hypertension \npregnancy \n \n"
],
"offsets": [
[
0,
65
]
]
}
] |
[
{
"id": "NCT02687178_exc_T1",
"type": "Condition",
"text": [
"diabetes mellitus"
],
"offsets": [
[
0,
17
]
],
"normalized": []
},
{
"id": "NCT02687178_exc_T2",
"type": "Condition",
"text": [
"secondary hypertension"
],
"offsets": [
[
19,
41
]
],
"normalized": []
},
{
"id": "NCT02687178_exc_T3",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
43,
52
]
],
"normalized": []
}
] |
[] |
[] |
[] |
NCT02687178_inc
|
NCT02687178
|
[
{
"id": "NCT02687178_inc_text",
"type": "inclusion",
"text": [
"Caucasian patients affected by uncomplicated, essential hypertension, not well controlled by concomitant administration of ACE-I or ARBs and diuretics at the maximum dosage. \n"
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "NCT02687178_inc_T1",
"type": "Person",
"text": [
"Caucasian"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "NCT02687178_inc_T2",
"type": "Condition",
"text": [
"essential hypertension"
],
"offsets": [
[
46,
68
]
],
"normalized": []
},
{
"id": "NCT02687178_inc_T3",
"type": "Qualifier",
"text": [
"uncomplicated"
],
"offsets": [
[
31,
44
]
],
"normalized": []
},
{
"id": "NCT02687178_inc_T4",
"type": "Drug",
"text": [
"ACE-I"
],
"offsets": [
[
123,
128
]
],
"normalized": []
},
{
"id": "NCT02687178_inc_T5",
"type": "Drug",
"text": [
"ARBs"
],
"offsets": [
[
132,
136
]
],
"normalized": []
},
{
"id": "NCT02687178_inc_T6",
"type": "Drug",
"text": [
"diuretics"
],
"offsets": [
[
141,
150
]
],
"normalized": []
},
{
"id": "NCT02687178_inc_T7",
"type": "Multiplier",
"text": [
"maximum dosage"
],
"offsets": [
[
158,
172
]
],
"normalized": []
},
{
"id": "NCT02687178_inc_T8",
"type": "Qualifier",
"text": [
"not well controlled"
],
"offsets": [
[
70,
89
]
],
"normalized": []
},
{
"id": "NCT02687178_inc_T9",
"type": "Scope",
"text": [
"ACE-I or ARBs and diuretics at the maximum dosage"
],
"offsets": [
[
123,
172
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02687178_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02687178_inc_T2",
"arg2_id": "NCT02687178_inc_T3",
"normalized": []
},
{
"id": "NCT02687178_inc_R2",
"type": "Has_multiplier",
"arg1_id": "NCT02687178_inc_T6",
"arg2_id": "NCT02687178_inc_T7",
"normalized": []
},
{
"id": "NCT02687178_inc_R3",
"type": "Has_multiplier",
"arg1_id": "NCT02687178_inc_T4",
"arg2_id": "NCT02687178_inc_T7",
"normalized": []
},
{
"id": "NCT02687178_inc_R4",
"type": "Has_multiplier",
"arg1_id": "NCT02687178_inc_T5",
"arg2_id": "NCT02687178_inc_T7",
"normalized": []
},
{
"id": "NCT02687178_inc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02687178_inc_T2",
"arg2_id": "NCT02687178_inc_T8",
"normalized": []
},
{
"id": "NCT02687178_inc_R6",
"type": "Has_scope",
"arg1_id": "NCT02687178_inc_T8",
"arg2_id": "NCT02687178_inc_T9",
"normalized": []
}
] |
NCT02687724_exc
|
NCT02687724
|
[
{
"id": "NCT02687724_exc_text",
"type": "exclusion",
"text": [
"Female subjects who are pregnant or breast-feeding or considering becoming pregnant during the study\nPatients aged <18 years of age\nPatients who cannot give informed consent,\nPregnant patients or those who are breastfeeding will be deemed ineligible.\nPrior treatment with any anti-TNF agent\nContra-indication to use of GLM (Hypersensitivity to the active substance or to any of the excipients; Active tuberculosis (TB), acute or chronic Hepatitis B infection or other severe infections such as sepsis and/or opportunistic infections including HIV infection; Moderate or severe heart failure (NYHA class III/IV)\nHave symptoms or signs suggestive of current active or latent TB upon medical history, physical examination and/or chest radiograph, or positive Mycobacterium tuberculosis antigen-specific interferon-gamma release assay (IGRA)\nPatients with a history of, or at imminent risk for, colectomy; who required gastrointestinal surgery within 2 months before screening;\nHistory of colonic mucosal dysplasia or adenomatous colonic polyps that were not removed\nScreening stool study positive for enteric pathogens or Clostridium difficile toxin.\nOral corticosteroids at a dose >40 mg prednisone or its equivalent per day; receipt of cyclosporine, tacrolimus, sirolimus, or mycophenolate mofetil within 8 weeks before the first study agent injection; or use of an investigational agent within 5 half-lives of that agent before the first study agent injection.\nPatients in recent receipt of live vaccinations within 4 weeks prior to enrolment\n"
],
"offsets": [
[
0,
1543
]
]
}
] |
[
{
"id": "NCT02687724_exc_T2",
"type": "Person",
"text": [
"aged"
],
"offsets": [
[
110,
114
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T3",
"type": "Value",
"text": [
"<18 years of age"
],
"offsets": [
[
115,
131
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T6",
"type": "Drug",
"text": [
"anti-TNF agent"
],
"offsets": [
[
276,
290
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T7",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
257,
266
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T8",
"type": "Temporal",
"text": [
"Prior"
],
"offsets": [
[
251,
256
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T9",
"type": "Condition",
"text": [
"Contra-indication"
],
"offsets": [
[
291,
308
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T10",
"type": "Drug",
"text": [
"GLM"
],
"offsets": [
[
319,
322
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T11",
"type": "Condition",
"text": [
"Hypersensitivity"
],
"offsets": [
[
324,
340
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T12",
"type": "Drug",
"text": [
"active substance"
],
"offsets": [
[
348,
364
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T13",
"type": "Drug",
"text": [
"excipients"
],
"offsets": [
[
382,
392
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T14",
"type": "Scope",
"text": [
"active substance or to any of the excipients"
],
"offsets": [
[
348,
392
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T15",
"type": "Condition",
"text": [
"tuberculosis (TB)"
],
"offsets": [
[
401,
418
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T16",
"type": "Temporal",
"text": [
"Active"
],
"offsets": [
[
394,
400
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T17",
"type": "Qualifier",
"text": [
"acute"
],
"offsets": [
[
420,
425
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T18",
"type": "Qualifier",
"text": [
"chronic"
],
"offsets": [
[
429,
436
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T19",
"type": "Condition",
"text": [
"Hepatitis B infection"
],
"offsets": [
[
437,
458
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T20",
"type": "Scope",
"text": [
"acute or chronic"
],
"offsets": [
[
420,
436
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T21",
"type": "Condition",
"text": [
"severe infections"
],
"offsets": [
[
468,
485
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T22",
"type": "Condition",
"text": [
"sepsis"
],
"offsets": [
[
494,
500
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T23",
"type": "Condition",
"text": [
"opportunistic infections"
],
"offsets": [
[
508,
532
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T24",
"type": "Condition",
"text": [
"HIV infection"
],
"offsets": [
[
543,
556
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T25",
"type": "Qualifier",
"text": [
"Moderate"
],
"offsets": [
[
558,
566
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T26",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
570,
576
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T27",
"type": "Condition",
"text": [
"heart failure"
],
"offsets": [
[
577,
590
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T28",
"type": "Measurement",
"text": [
"NYHA"
],
"offsets": [
[
592,
596
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T29",
"type": "Value",
"text": [
"class III/IV"
],
"offsets": [
[
597,
609
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T30",
"type": "Scope",
"text": [
"Moderate or severe"
],
"offsets": [
[
558,
576
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T31",
"type": "Scope",
"text": [
"Hypersensitivity to the active substance or to any of the excipients; Active tuberculosis (TB), acute or chronic Hepatitis B infection or other severe infections such as sepsis and/or opportunistic infections including HIV infection; Moderate or severe heart failure (NYHA class III/IV"
],
"offsets": [
[
324,
609
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T32",
"type": "Scope",
"text": [
"Contra-indication to use of GLM"
],
"offsets": [
[
291,
322
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T33",
"type": "Qualifier",
"text": [
"latent"
],
"offsets": [
[
666,
672
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T34",
"type": "Qualifier",
"text": [
"active"
],
"offsets": [
[
656,
662
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T35",
"type": "Temporal",
"text": [
"current"
],
"offsets": [
[
648,
655
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T36",
"type": "Condition",
"text": [
"TB"
],
"offsets": [
[
673,
675
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T37",
"type": "Scope",
"text": [
"current active or laten"
],
"offsets": [
[
648,
671
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T38",
"type": "Observation",
"text": [
"medical history"
],
"offsets": [
[
681,
696
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T39",
"type": "Procedure",
"text": [
"physical examination"
],
"offsets": [
[
698,
718
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T40",
"type": "Procedure",
"text": [
"chest radiograph"
],
"offsets": [
[
726,
742
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T41",
"type": "Measurement",
"text": [
"Mycobacterium tuberculosis antigen-specific interferon-gamma release assay (IGRA)"
],
"offsets": [
[
756,
837
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T42",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
747,
755
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T43",
"type": "Scope",
"text": [
"medical history, physical examination and/or chest radiograph"
],
"offsets": [
[
681,
742
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T44",
"type": "Procedure",
"text": [
"gastrointestinal surgery"
],
"offsets": [
[
915,
939
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T45",
"type": "Temporal",
"text": [
"within 2 months before screening"
],
"offsets": [
[
940,
972
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T46",
"type": "Procedure",
"text": [
"colectomy"
],
"offsets": [
[
891,
900
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T47",
"type": "Mood",
"text": [
"imminent risk for"
],
"offsets": [
[
872,
889
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T48",
"type": "Observation",
"text": [
"history of"
],
"offsets": [
[
854,
864
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T49",
"type": "Scope",
"text": [
"history of, or at imminent risk for"
],
"offsets": [
[
854,
889
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T50",
"type": "Condition",
"text": [
"colonic mucosal dysplasia"
],
"offsets": [
[
985,
1010
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T51",
"type": "Condition",
"text": [
"adenomatous colonic polyps"
],
"offsets": [
[
1014,
1040
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T52",
"type": "Procedure",
"text": [
"removed"
],
"offsets": [
[
1055,
1062
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T53",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
1051,
1054
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T54",
"type": "Procedure",
"text": [
"stool study"
],
"offsets": [
[
1073,
1084
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T55",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
1085,
1093
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T56",
"type": "Qualifier",
"text": [
"enteric pathogens"
],
"offsets": [
[
1098,
1115
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T57",
"type": "Qualifier",
"text": [
"Clostridium difficile toxin"
],
"offsets": [
[
1119,
1146
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T58",
"type": "Scope",
"text": [
"enteric pathogens or Clostridium difficile toxin"
],
"offsets": [
[
1098,
1146
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T59",
"type": "Drug",
"text": [
"Oral corticosteroids"
],
"offsets": [
[
1148,
1168
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T60",
"type": "Multiplier",
"text": [
"dnisone or its eq",
"eceipt"
],
"offsets": [
[
1189,
1206
],
[
1225,
1231
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T61",
"type": "Drug",
"text": [
"cyclosporine"
],
"offsets": [
[
1235,
1247
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T62",
"type": "Drug",
"text": [
"tacrolimus"
],
"offsets": [
[
1249,
1259
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T63",
"type": "Drug",
"text": [
"sirolimus"
],
"offsets": [
[
1261,
1270
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T64",
"type": "Drug",
"text": [
"mycophenolate mofetil"
],
"offsets": [
[
1275,
1296
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T65",
"type": "Temporal",
"text": [
"within 8 weeks before the first study agent injection"
],
"offsets": [
[
1297,
1350
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T66",
"type": "Scope",
"text": [
"cyclosporine, tacrolimus, sirolimus, or mycophenolate mofetil"
],
"offsets": [
[
1235,
1296
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T67",
"type": "Drug",
"text": [
"investigational agent"
],
"offsets": [
[
1365,
1386
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T68",
"type": "Temporal",
"text": [
"within 5 half-lives"
],
"offsets": [
[
1387,
1406
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T69",
"type": "Temporal",
"text": [
"before the first study agent injection"
],
"offsets": [
[
1421,
1459
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T70",
"type": "Drug",
"text": [
"live vaccinations"
],
"offsets": [
[
1491,
1508
]
],
"normalized": []
},
{
"id": "NCT02687724_exc_T71",
"type": "Temporal",
"text": [
"within 4 weeks prior to enrolment"
],
"offsets": [
[
1509,
1542
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02687724_exc_R1",
"type": "Has_value",
"arg1_id": "NCT02687724_exc_T2",
"arg2_id": "NCT02687724_exc_T3",
"normalized": []
},
{
"id": "NCT02687724_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02687724_exc_T7",
"arg2_id": "NCT02687724_exc_T8",
"normalized": []
},
{
"id": "NCT02687724_exc_R3",
"type": "AND",
"arg1_id": "NCT02687724_exc_T7",
"arg2_id": "NCT02687724_exc_T6",
"normalized": []
},
{
"id": "NCT02687724_exc_R4",
"type": "Has_scope",
"arg1_id": "NCT02687724_exc_T11",
"arg2_id": "NCT02687724_exc_T14",
"normalized": []
},
{
"id": "NCT02687724_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02687724_exc_T15",
"arg2_id": "NCT02687724_exc_T16",
"normalized": []
},
{
"id": "NCT02687724_exc_R6",
"type": "Has_scope",
"arg1_id": "NCT02687724_exc_T19",
"arg2_id": "NCT02687724_exc_T20",
"normalized": []
},
{
"id": "NCT02687724_exc_R7",
"type": "Subsumes",
"arg1_id": "NCT02687724_exc_T23",
"arg2_id": "NCT02687724_exc_T24",
"normalized": []
},
{
"id": "NCT02687724_exc_R8",
"type": "Subsumes",
"arg1_id": "NCT02687724_exc_T21",
"arg2_id": "NCT02687724_exc_T22",
"normalized": []
},
{
"id": "NCT02687724_exc_R9",
"type": "Has_value",
"arg1_id": "NCT02687724_exc_T28",
"arg2_id": "NCT02687724_exc_T29",
"normalized": []
},
{
"id": "NCT02687724_exc_R10",
"type": "Subsumes",
"arg1_id": "NCT02687724_exc_T30",
"arg2_id": "NCT02687724_exc_T28",
"normalized": []
},
{
"id": "NCT02687724_exc_R11",
"type": "Has_scope",
"arg1_id": "NCT02687724_exc_T27",
"arg2_id": "NCT02687724_exc_T30",
"normalized": []
},
{
"id": "NCT02687724_exc_R12",
"type": "AND",
"arg1_id": "NCT02687724_exc_T9",
"arg2_id": "NCT02687724_exc_T10",
"normalized": []
},
{
"id": "NCT02687724_exc_R13",
"type": "Subsumes",
"arg1_id": "NCT02687724_exc_T32",
"arg2_id": "NCT02687724_exc_T31",
"normalized": []
},
{
"id": "NCT02687724_exc_R14",
"type": "Has_temporal",
"arg1_id": "NCT02687724_exc_T34",
"arg2_id": "NCT02687724_exc_T35",
"normalized": []
},
{
"id": "NCT02687724_exc_R15",
"type": "Has_scope",
"arg1_id": "NCT02687724_exc_T36",
"arg2_id": "NCT02687724_exc_T37",
"normalized": []
},
{
"id": "NCT02687724_exc_R16",
"type": "Has_value",
"arg1_id": "NCT02687724_exc_T41",
"arg2_id": "NCT02687724_exc_T42",
"normalized": []
},
{
"id": "NCT02687724_exc_R17",
"type": "AND",
"arg1_id": "NCT02687724_exc_T43",
"arg2_id": "NCT02687724_exc_T36",
"normalized": []
},
{
"id": "NCT02687724_exc_R18",
"type": "Has_temporal",
"arg1_id": "NCT02687724_exc_T44",
"arg2_id": "NCT02687724_exc_T45",
"normalized": []
},
{
"id": "NCT02687724_exc_R19",
"type": "Has_scope",
"arg1_id": "NCT02687724_exc_T46",
"arg2_id": "NCT02687724_exc_T49",
"normalized": []
},
{
"id": "NCT02687724_exc_R20",
"type": "Has_negation",
"arg1_id": "NCT02687724_exc_T52",
"arg2_id": "NCT02687724_exc_T53",
"normalized": []
},
{
"id": "NCT02687724_exc_R21",
"type": "AND",
"arg1_id": "NCT02687724_exc_T51",
"arg2_id": "NCT02687724_exc_T52",
"normalized": []
},
{
"id": "NCT02687724_exc_R22",
"type": "Has_scope",
"arg1_id": "NCT02687724_exc_T55",
"arg2_id": "NCT02687724_exc_T58",
"normalized": []
},
{
"id": "NCT02687724_exc_R23",
"type": "Has_value",
"arg1_id": "NCT02687724_exc_T54",
"arg2_id": "NCT02687724_exc_T55",
"normalized": []
},
{
"id": "NCT02687724_exc_R24",
"type": "Has_multiplier",
"arg1_id": "NCT02687724_exc_T59",
"arg2_id": "NCT02687724_exc_T60",
"normalized": []
},
{
"id": "NCT02687724_exc_R25",
"type": "Has_temporal",
"arg1_id": "NCT02687724_exc_T66",
"arg2_id": "NCT02687724_exc_T65",
"normalized": []
},
{
"id": "NCT02687724_exc_R26",
"type": "Has_temporal",
"arg1_id": "NCT02687724_exc_T67",
"arg2_id": "NCT02687724_exc_T68",
"normalized": []
},
{
"id": "NCT02687724_exc_R27",
"type": "Has_temporal",
"arg1_id": "NCT02687724_exc_T67",
"arg2_id": "NCT02687724_exc_T69",
"normalized": []
},
{
"id": "NCT02687724_exc_R28",
"type": "Has_temporal",
"arg1_id": "NCT02687724_exc_T70",
"arg2_id": "NCT02687724_exc_T71",
"normalized": []
}
] |
NCT02687724_inc
|
NCT02687724
|
[
{
"id": "NCT02687724_inc_text",
"type": "inclusion",
"text": [
"Patients = 18 years of age\nSubjects must be able and willing to give written informed consent and to comply with the requirements of this study protocol\nEstablished diagnosis of UC and moderate-to-severe disease activity, defined as a Mayo score of 6-12, with an endoscopic subscore =2.\nPatients had an inadequate response to, or had failed to tolerate, 1 or more of the following conventional therapies: oral 5-aminosalicylates, oral corticosteroids, azathioprine (AZA), and/or 6-mercaptopurine (6MP); or corticosteroid dependent (ie, an inability to taper corticosteroids without recurrence of UC symptoms).\nPatients concurrently treated with oral 5-aminosalicylates or corticosteroids were to receive a stable dose for at least 2 weeks before baseline, and patients receiving AZA and/or 6MP were to receive a stable dose for at least 4 weeks before baseline. Patients were required to maintain stable doses of their concomitant UC medications during the study.\nFemale subjects of child bearing potential must be willing to ensure that they or their partner use effective contraception during the study and for 6 months thereafter OR\nSurgical sterilized female patients with documentation of prior hysterectomy, tubal ligation or complete bilateral oophorectomy OR\nPostmenopausal women with postmenopausal defined as permanent cessation >1 year of previously occurring menses.\nFemale subjects' serum pregnancy test performed at the screening visit and urine pregnancy test performed at the baseline visit must be negative.\nSubjects have following investigations within 1 month prior to enrolment.\nRoutine bloods including U&E, FBC, LFTs, inflammatory markers (CRP) and albumin will be measured.\nMedical history, concomitant medications\nIntradermal reaction to Tuberculin (PPD skin test) or Mycobacterium tuberculosis antigenspecific interferon-gamma release assay (IGRA)\nTB screening: chest X-Ray unless performed in the last 6 months\nStool examination for enteric pathogens including Clostridium difficile\nInclusion/exclusion criteria\nInformed consent\nMayo score (including sigmoidoscopy unless performed in previous 3 months)\nPatient's weight and height and abdominal circumference\n"
],
"offsets": [
[
0,
2186
]
]
}
] |
[
{
"id": "NCT02687724_inc_T1",
"type": "Value",
"text": [
"= 18 years"
],
"offsets": [
[
9,
19
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T2",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
23,
26
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T4",
"type": "Condition",
"text": [
"UC"
],
"offsets": [
[
178,
180
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T5",
"type": "Qualifier",
"text": [
"moderate-to-severe"
],
"offsets": [
[
185,
203
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T6",
"type": "Measurement",
"text": [
"Mayo score"
],
"offsets": [
[
235,
245
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T7",
"type": "Value",
"text": [
"6-12"
],
"offsets": [
[
249,
253
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T8",
"type": "Measurement",
"text": [
"endoscopic subscore"
],
"offsets": [
[
263,
282
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T9",
"type": "Value",
"text": [
"=2"
],
"offsets": [
[
283,
285
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T10",
"type": "Condition",
"text": [
"inadequate response"
],
"offsets": [
[
303,
322
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T11",
"type": "Condition",
"text": [
"failed to tolerate"
],
"offsets": [
[
334,
352
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T12",
"type": "Multiplier",
"text": [
"1 or more"
],
"offsets": [
[
354,
363
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T13",
"type": "Drug",
"text": [
"oral 5-aminosalicylates"
],
"offsets": [
[
405,
428
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T14",
"type": "Drug",
"text": [
"oral corticosteroids"
],
"offsets": [
[
430,
450
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T15",
"type": "Drug",
"text": [
"azathioprine (AZA)"
],
"offsets": [
[
452,
470
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T16",
"type": "Drug",
"text": [
"6-mercaptopurine (6MP)"
],
"offsets": [
[
479,
501
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T17",
"type": "Drug",
"text": [
"corticosteroid"
],
"offsets": [
[
506,
520
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T18",
"type": "Condition",
"text": [
"dependent"
],
"offsets": [
[
521,
530
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T20",
"type": "Scope",
"text": [
"oral 5-aminosalicylates, oral corticosteroids, azathioprine (AZA), and/or 6-mercaptopurine (6MP)"
],
"offsets": [
[
405,
501
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T21",
"type": "Scope",
"text": [
"inadequate response to, or had failed to tolerate"
],
"offsets": [
[
303,
352
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T22",
"type": "Drug",
"text": [
"oral 5-aminosalicylates"
],
"offsets": [
[
645,
668
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T24",
"type": "Drug",
"text": [
"corticosteroids"
],
"offsets": [
[
672,
687
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T25",
"type": "Qualifier",
"text": [
"stable dose"
],
"offsets": [
[
706,
717
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T26",
"type": "Temporal",
"text": [
"for at least 2 weeks before baseline"
],
"offsets": [
[
718,
754
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T27",
"type": "Scope",
"text": [
"oral 5-aminosalicylates or corticosteroids"
],
"offsets": [
[
645,
687
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T28",
"type": "Drug",
"text": [
"AZA"
],
"offsets": [
[
779,
782
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T29",
"type": "Drug",
"text": [
"6MP"
],
"offsets": [
[
790,
793
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T23",
"type": "Qualifier",
"text": [
"stable dose"
],
"offsets": [
[
812,
823
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T30",
"type": "Temporal",
"text": [
"for at least 4 weeks before baseline"
],
"offsets": [
[
824,
860
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T31",
"type": "Scope",
"text": [
"AZA and/or 6MP"
],
"offsets": [
[
779,
793
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T32",
"type": "Procedure",
"text": [
"treated"
],
"offsets": [
[
632,
639
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T33",
"type": "Scope",
"text": [
"oral 5-aminosalicylates or corticosteroids were to receive a stable dose for at least 2 weeks before baseline, and patients receiving AZA and/or 6MP were to receive a stable dose for at least 4 weeks before baseline"
],
"offsets": [
[
645,
860
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T40",
"type": "Procedure",
"text": [
"Routine bloods"
],
"offsets": [
[
1599,
1613
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T41",
"type": "Procedure",
"text": [
"U&E"
],
"offsets": [
[
1624,
1627
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T42",
"type": "Procedure",
"text": [
"FBC"
],
"offsets": [
[
1629,
1632
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T43",
"type": "Procedure",
"text": [
"LFTs"
],
"offsets": [
[
1634,
1638
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T44",
"type": "Procedure",
"text": [
"inflammatory markers (CRP)"
],
"offsets": [
[
1640,
1666
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T45",
"type": "Procedure",
"text": [
"albumin"
],
"offsets": [
[
1671,
1678
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T46",
"type": "Scope",
"text": [
"U&E, FBC, LFTs, inflammatory markers (CRP) and albumin"
],
"offsets": [
[
1624,
1678
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T48",
"type": "Procedure",
"text": [
"Intradermal reaction to Tuberculin (PPD skin test)"
],
"offsets": [
[
1738,
1788
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T49",
"type": "Procedure",
"text": [
"Mycobacterium tuberculosis antigenspecific interferon-gamma release assay (IGRA)"
],
"offsets": [
[
1792,
1872
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T50",
"type": "Temporal",
"text": [
"within 1 month prior to enrolment"
],
"offsets": [
[
1564,
1597
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T51",
"type": "Procedure",
"text": [
"chest X-Ray"
],
"offsets": [
[
1887,
1898
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T52",
"type": "Procedure",
"text": [
"TB screening"
],
"offsets": [
[
1873,
1885
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T53",
"type": "Procedure",
"text": [
"Stool examination"
],
"offsets": [
[
1937,
1954
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T54",
"type": "Qualifier",
"text": [
"for enteric pathogens including Clostridium difficile"
],
"offsets": [
[
1955,
2008
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T57",
"type": "Procedure",
"text": [
"Mayo score"
],
"offsets": [
[
2055,
2065
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T58",
"type": "Procedure",
"text": [
"sigmoidoscopy"
],
"offsets": [
[
2077,
2090
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T59",
"type": "Procedure",
"text": [
"abdominal circumference"
],
"offsets": [
[
2162,
2185
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T60",
"type": "Procedure",
"text": [
"height"
],
"offsets": [
[
2151,
2157
]
],
"normalized": []
},
{
"id": "NCT02687724_inc_T61",
"type": "Procedure",
"text": [
"weight"
],
"offsets": [
[
2140,
2146
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02687724_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02687724_inc_T2",
"arg2_id": "NCT02687724_inc_T1",
"normalized": []
},
{
"id": "NCT02687724_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02687724_inc_T6",
"arg2_id": "NCT02687724_inc_T7",
"normalized": []
},
{
"id": "NCT02687724_inc_R3",
"type": "AND",
"arg1_id": "NCT02687724_inc_T6",
"arg2_id": "NCT02687724_inc_T8",
"normalized": []
},
{
"id": "NCT02687724_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02687724_inc_T8",
"arg2_id": "NCT02687724_inc_T9",
"normalized": []
},
{
"id": "NCT02687724_inc_R5",
"type": "Subsumes",
"arg1_id": "NCT02687724_inc_T5",
"arg2_id": "NCT02687724_inc_T6",
"normalized": []
},
{
"id": "NCT02687724_inc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT02687724_inc_T4",
"arg2_id": "NCT02687724_inc_T5",
"normalized": []
},
{
"id": "NCT02687724_inc_R7",
"type": "AND",
"arg1_id": "NCT02687724_inc_T18",
"arg2_id": "NCT02687724_inc_T17",
"normalized": []
},
{
"id": "NCT02687724_inc_R8",
"type": "Has_multiplier",
"arg1_id": "NCT02687724_inc_T20",
"arg2_id": "NCT02687724_inc_T12",
"normalized": []
},
{
"id": "NCT02687724_inc_R9",
"type": "Has_scope",
"arg1_id": "NCT02687724_inc_T21",
"arg2_id": "NCT02687724_inc_T20",
"normalized": []
},
{
"id": "NCT02687724_inc_R10",
"type": "Has_temporal",
"arg1_id": "NCT02687724_inc_T25",
"arg2_id": "NCT02687724_inc_T26",
"normalized": []
},
{
"id": "NCT02687724_inc_R11",
"type": "Has_temporal",
"arg1_id": "NCT02687724_inc_T23",
"arg2_id": "NCT02687724_inc_T30",
"normalized": []
},
{
"id": "NCT02687724_inc_R12",
"type": "Has_qualifier",
"arg1_id": "NCT02687724_inc_T31",
"arg2_id": "NCT02687724_inc_T23",
"normalized": []
},
{
"id": "NCT02687724_inc_R13",
"type": "Has_qualifier",
"arg1_id": "NCT02687724_inc_T27",
"arg2_id": "NCT02687724_inc_T25",
"normalized": []
},
{
"id": "NCT02687724_inc_R14",
"type": "Has_scope",
"arg1_id": "NCT02687724_inc_T32",
"arg2_id": "NCT02687724_inc_T33",
"normalized": []
},
{
"id": "NCT02687724_inc_R15",
"type": "Subsumes",
"arg1_id": "NCT02687724_inc_T40",
"arg2_id": "NCT02687724_inc_T46",
"normalized": []
},
{
"id": "NCT02687724_inc_R16",
"type": "Subsumes",
"arg1_id": "NCT02687724_inc_T52",
"arg2_id": "NCT02687724_inc_T51",
"normalized": []
},
{
"id": "NCT02687724_inc_R17",
"type": "Has_qualifier",
"arg1_id": "NCT02687724_inc_T53",
"arg2_id": "NCT02687724_inc_T54",
"normalized": []
},
{
"id": "NCT02687724_inc_R18",
"type": "Subsumes",
"arg1_id": "NCT02687724_inc_T57",
"arg2_id": "NCT02687724_inc_T58",
"normalized": []
}
] |
NCT02689024_exc
|
NCT02689024
|
[
{
"id": "NCT02689024_exc_text",
"type": "exclusion",
"text": [
"multiple injuries (polytrauma patients)\nprevious adverse reaction or known allergy to local anaesthetics or opioids or paracetamol\nskin infection in proximity of injection site\ndelirious state at presentation in the ED\n"
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
"id": "NCT02689024_exc_T1",
"type": "Condition",
"text": [
"multiple injuries"
],
"offsets": [
[
0,
17
]
],
"normalized": []
},
{
"id": "NCT02689024_exc_T2",
"type": "Condition",
"text": [
"polytrauma"
],
"offsets": [
[
19,
29
]
],
"normalized": []
},
{
"id": "NCT02689024_exc_T3",
"type": "Condition",
"text": [
"adverse reaction"
],
"offsets": [
[
49,
65
]
],
"normalized": []
},
{
"id": "NCT02689024_exc_T4",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
75,
82
]
],
"normalized": []
},
{
"id": "NCT02689024_exc_T5",
"type": "Procedure",
"text": [
"local anaesthetics"
],
"offsets": [
[
86,
104
]
],
"normalized": []
},
{
"id": "NCT02689024_exc_T6",
"type": "Drug",
"text": [
"opioids"
],
"offsets": [
[
108,
115
]
],
"normalized": []
},
{
"id": "NCT02689024_exc_T7",
"type": "Drug",
"text": [
"paracetamol"
],
"offsets": [
[
119,
130
]
],
"normalized": []
},
{
"id": "NCT02689024_exc_T8",
"type": "Scope",
"text": [
"local anaesthetics or opioids or paracetamol"
],
"offsets": [
[
86,
130
]
],
"normalized": []
},
{
"id": "NCT02689024_exc_T9",
"type": "Scope",
"text": [
"adverse reaction or known allergy"
],
"offsets": [
[
49,
82
]
],
"normalized": []
},
{
"id": "NCT02689024_exc_T10",
"type": "Condition",
"text": [
"skin infection"
],
"offsets": [
[
131,
145
]
],
"normalized": []
},
{
"id": "NCT02689024_exc_T11",
"type": "Qualifier",
"text": [
"injection site"
],
"offsets": [
[
162,
176
]
],
"normalized": []
},
{
"id": "NCT02689024_exc_T12",
"type": "Condition",
"text": [
"delirious"
],
"offsets": [
[
177,
186
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02689024_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT02689024_exc_T1",
"arg2_id": "NCT02689024_exc_T2",
"normalized": []
},
{
"id": "NCT02689024_exc_R2",
"type": "Has_scope",
"arg1_id": "NCT02689024_exc_T9",
"arg2_id": "NCT02689024_exc_T8",
"normalized": []
},
{
"id": "NCT02689024_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02689024_exc_T10",
"arg2_id": "NCT02689024_exc_T11",
"normalized": []
}
] |
NCT02689024_inc
|
NCT02689024
|
[
{
"id": "NCT02689024_inc_text",
"type": "inclusion",
"text": [
"adult patients aged = 55 years with\na radiographically confirmed hip fracture\n"
],
"offsets": [
[
0,
78
]
]
}
] |
[
{
"id": "NCT02689024_inc_T1",
"type": "Person",
"text": [
"adult"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02689024_inc_T2",
"type": "Person",
"text": [
"aged"
],
"offsets": [
[
15,
19
]
],
"normalized": []
},
{
"id": "NCT02689024_inc_T3",
"type": "Value",
"text": [
"= 55 years"
],
"offsets": [
[
20,
30
]
],
"normalized": []
},
{
"id": "NCT02689024_inc_T4",
"type": "Condition",
"text": [
"hip fracture"
],
"offsets": [
[
65,
77
]
],
"normalized": []
},
{
"id": "NCT02689024_inc_T5",
"type": "Procedure",
"text": [
"radiographically"
],
"offsets": [
[
38,
54
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02689024_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02689024_inc_T2",
"arg2_id": "NCT02689024_inc_T3",
"normalized": []
},
{
"id": "NCT02689024_inc_R2",
"type": "AND",
"arg1_id": "NCT02689024_inc_T5",
"arg2_id": "NCT02689024_inc_T4",
"normalized": []
}
] |
NCT02689089_exc
|
NCT02689089
|
[
{
"id": "NCT02689089_exc_text",
"type": "exclusion",
"text": [
"Suspected or confirmed active TB disease\nKnown allergies to any of the study medications by participant self-report\nhave a positive pregnancy test at screening, or\nare not willing to use a reliable method of barrier contraception during the study, or\nare breastfeeding\nhormonal contraception\nHIV infected participants who are on anti-retroviral drugs\nother drugs that interact with 3HP (see Table 1)\nKnown contact with an INH or rifampin resistant case\nWeight < 10 kg\nEvidence of possible liver damage defined by an aspartate transaminase (AST) level that is more than 3x the upper limit of normal in an asymptomatic patient\nPorphyria reported by patient\nInability to adhere to protocol.\nPatients may be excluded from the study for other reasons, at the investigator's discretion with detailed documentation.\n"
],
"offsets": [
[
0,
809
]
]
}
] |
[
{
"id": "NCT02689089_exc_T1",
"type": "Condition",
"text": [
"active TB"
],
"offsets": [
[
23,
32
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T2",
"type": "Condition",
"text": [
"allergies"
],
"offsets": [
[
47,
56
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T7",
"type": "Procedure",
"text": [
"hormonal contraception"
],
"offsets": [
[
269,
291
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T8",
"type": "Condition",
"text": [
"HIV infected"
],
"offsets": [
[
292,
304
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T9",
"type": "Drug",
"text": [
"anti-retroviral drugs"
],
"offsets": [
[
329,
350
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T11",
"type": "Condition",
"text": [
"resistant"
],
"offsets": [
[
438,
447
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T12",
"type": "Drug",
"text": [
"rifampin"
],
"offsets": [
[
429,
437
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T13",
"type": "Drug",
"text": [
"INH"
],
"offsets": [
[
422,
425
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T14",
"type": "Scope",
"text": [
"INH or rifampin"
],
"offsets": [
[
422,
437
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T15",
"type": "Measurement",
"text": [
"Weight"
],
"offsets": [
[
453,
459
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T16",
"type": "Value",
"text": [
"< 10 kg"
],
"offsets": [
[
460,
467
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T17",
"type": "Condition",
"text": [
"liver damage"
],
"offsets": [
[
489,
501
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T18",
"type": "Measurement",
"text": [
"aspartate transaminase"
],
"offsets": [
[
516,
538
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T19",
"type": "Measurement",
"text": [
"AST"
],
"offsets": [
[
540,
543
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T20",
"type": "Value",
"text": [
"more than 3x the upper limit of normal"
],
"offsets": [
[
559,
597
]
],
"normalized": []
},
{
"id": "NCT02689089_exc_T21",
"type": "Condition",
"text": [
"Porphyria"
],
"offsets": [
[
625,
634
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02689089_exc_R1",
"type": "AND",
"arg1_id": "NCT02689089_exc_T8",
"arg2_id": "NCT02689089_exc_T9",
"normalized": []
},
{
"id": "NCT02689089_exc_R2",
"type": "Has_scope",
"arg1_id": "NCT02689089_exc_T11",
"arg2_id": "NCT02689089_exc_T14",
"normalized": []
},
{
"id": "NCT02689089_exc_R3",
"type": "Has_value",
"arg1_id": "NCT02689089_exc_T15",
"arg2_id": "NCT02689089_exc_T16",
"normalized": []
},
{
"id": "NCT02689089_exc_R4",
"type": "Subsumes",
"arg1_id": "NCT02689089_exc_T18",
"arg2_id": "NCT02689089_exc_T19",
"normalized": []
},
{
"id": "NCT02689089_exc_R5",
"type": "AND",
"arg1_id": "NCT02689089_exc_T17",
"arg2_id": "NCT02689089_exc_T18",
"normalized": []
},
{
"id": "NCT02689089_exc_R6",
"type": "Has_value",
"arg1_id": "NCT02689089_exc_T18",
"arg2_id": "NCT02689089_exc_T20",
"normalized": []
}
] |
NCT02689089_inc
|
NCT02689089
|
[
{
"id": "NCT02689089_inc_text",
"type": "inclusion",
"text": [
"Males or non-pregnant, non-nursing females between the ages of 2-65 years\nLTBI diagnosis as per Canadian TB Standards using either the Tuberculin Skin Test (TST) or the Interferon Gamma Release Assay (IGRA)\nChildren 2-5 years with negative TSTs who have been in close contact with a case of active TB disease recently\nAble and willing to provide fully informed consent or parent/guardian able to provide consent\n"
],
"offsets": [
[
0,
412
]
]
}
] |
[
{
"id": "NCT02689089_inc_T1",
"type": "Person",
"text": [
"Males"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02689089_inc_T3",
"type": "Person",
"text": [
"females"
],
"offsets": [
[
35,
42
]
],
"normalized": []
},
{
"id": "NCT02689089_inc_T4",
"type": "Person",
"text": [
"ages"
],
"offsets": [
[
55,
59
]
],
"normalized": []
},
{
"id": "NCT02689089_inc_T5",
"type": "Value",
"text": [
"2-65 years"
],
"offsets": [
[
63,
73
]
],
"normalized": []
},
{
"id": "NCT02689089_inc_T6",
"type": "Condition",
"text": [
"LTBI"
],
"offsets": [
[
74,
78
]
],
"normalized": []
},
{
"id": "NCT02689089_inc_T7",
"type": "Measurement",
"text": [
"Tuberculin Skin Test"
],
"offsets": [
[
135,
155
]
],
"normalized": []
},
{
"id": "NCT02689089_inc_T8",
"type": "Measurement",
"text": [
"TST"
],
"offsets": [
[
157,
160
]
],
"normalized": []
},
{
"id": "NCT02689089_inc_T9",
"type": "Measurement",
"text": [
"Interferon Gamma Release Assay"
],
"offsets": [
[
169,
199
]
],
"normalized": []
},
{
"id": "NCT02689089_inc_T10",
"type": "Measurement",
"text": [
"IGRA"
],
"offsets": [
[
201,
205
]
],
"normalized": []
},
{
"id": "NCT02689089_inc_T11",
"type": "Scope",
"text": [
"Tuberculin Skin Test (TST) or the Interferon Gamma Release Assay (IGRA)"
],
"offsets": [
[
135,
206
]
],
"normalized": []
},
{
"id": "NCT02689089_inc_T12",
"type": "Person",
"text": [
"Children"
],
"offsets": [
[
207,
215
]
],
"normalized": []
},
{
"id": "NCT02689089_inc_T13",
"type": "Person",
"text": [
"years"
],
"offsets": [
[
220,
225
]
],
"normalized": []
},
{
"id": "NCT02689089_inc_T14",
"type": "Value",
"text": [
"2-5"
],
"offsets": [
[
216,
219
]
],
"normalized": []
},
{
"id": "NCT02689089_inc_T15",
"type": "Measurement",
"text": [
"TSTs"
],
"offsets": [
[
240,
244
]
],
"normalized": []
},
{
"id": "NCT02689089_inc_T16",
"type": "Value",
"text": [
"negative"
],
"offsets": [
[
231,
239
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02689089_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02689089_inc_T4",
"arg2_id": "NCT02689089_inc_T5",
"normalized": []
},
{
"id": "NCT02689089_inc_R2",
"type": "Subsumes",
"arg1_id": "NCT02689089_inc_T7",
"arg2_id": "NCT02689089_inc_T8",
"normalized": []
},
{
"id": "NCT02689089_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT02689089_inc_T9",
"arg2_id": "NCT02689089_inc_T10",
"normalized": []
},
{
"id": "NCT02689089_inc_R4",
"type": "AND",
"arg1_id": "NCT02689089_inc_T11",
"arg2_id": "NCT02689089_inc_T6",
"normalized": []
},
{
"id": "NCT02689089_inc_R5",
"type": "Has_value",
"arg1_id": "NCT02689089_inc_T13",
"arg2_id": "NCT02689089_inc_T14",
"normalized": []
},
{
"id": "NCT02689089_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02689089_inc_T15",
"arg2_id": "NCT02689089_inc_T16",
"normalized": []
}
] |
NCT02689817_exc
|
NCT02689817
|
[
{
"id": "NCT02689817_exc_text",
"type": "exclusion",
"text": [
"Existing sacral pressure ulcer, undergoing a cardiac procedure, or inability to provide informed consent. \n \n"
],
"offsets": [
[
0,
118
]
]
}
] |
[
{
"id": "NCT02689817_exc_T1",
"type": "Condition",
"text": [
"sacral pressure ulcer"
],
"offsets": [
[
9,
30
]
],
"normalized": []
},
{
"id": "NCT02689817_exc_T2",
"type": "Procedure",
"text": [
"cardiac procedure"
],
"offsets": [
[
45,
62
]
],
"normalized": []
},
{
"id": "NCT02689817_exc_T4",
"type": "Condition",
"text": [
"inability to provide informed consent"
],
"offsets": [
[
67,
104
]
],
"normalized": []
}
] |
[] |
[] |
[] |
NCT02689817_inc
|
NCT02689817
|
[
{
"id": "NCT02689817_inc_text",
"type": "inclusion",
"text": [
"Patients undergoing an operation that is scheduled to last more than 2 hours \n"
],
"offsets": [
[
0,
78
]
]
}
] |
[
{
"id": "NCT02689817_inc_T1",
"type": "Procedure",
"text": [
"operation"
],
"offsets": [
[
23,
32
]
],
"normalized": []
},
{
"id": "NCT02689817_inc_T2",
"type": "Qualifier",
"text": [
"scheduled to last more than 2 hours"
],
"offsets": [
[
41,
76
]
],
"normalized": []
},
{
"id": "NCT02689817_inc_T3",
"type": "Temporal",
"text": [
"last more than 2 hours"
],
"offsets": [
[
54,
76
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02689817_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02689817_inc_T1",
"arg2_id": "NCT02689817_inc_T2",
"normalized": []
}
] |
NCT02691793_exc
|
NCT02691793
|
[
{
"id": "NCT02691793_exc_text",
"type": "exclusion",
"text": [
"Patients with second primary cancer, except:adequately treated non-melanoma skin cancer, curatively treated in-situ cancer of the cervix, or other solid tumor curatively treated with no evidence of disease for <= 5 years.\nHas known active central nervous system(CNS) metastases\nHas an active infection requiring systemic therapy\nPregnancy or breast feeding\nPatients with cardiac problem\nAny previous treatment with sunitinib\n"
],
"offsets": [
[
0,
425
]
]
}
] |
[
{
"id": "NCT02691793_exc_T1",
"type": "Qualifier",
"text": [
"second"
],
"offsets": [
[
14,
20
]
],
"normalized": []
},
{
"id": "NCT02691793_exc_T2",
"type": "Condition",
"text": [
"primary cancer,"
],
"offsets": [
[
21,
36
]
],
"normalized": []
},
{
"id": "NCT02691793_exc_T3",
"type": "Negation",
"text": [
"except"
],
"offsets": [
[
37,
43
]
],
"normalized": []
},
{
"id": "NCT02691793_exc_T4",
"type": "Condition",
"text": [
"non-melanoma skin cancer"
],
"offsets": [
[
63,
87
]
],
"normalized": []
},
{
"id": "NCT02691793_exc_T5",
"type": "Condition",
"text": [
"in-situ cancer of the cervix"
],
"offsets": [
[
108,
136
]
],
"normalized": []
},
{
"id": "NCT02691793_exc_T6",
"type": "Condition",
"text": [
"solid tumor"
],
"offsets": [
[
147,
158
]
],
"normalized": []
},
{
"id": "NCT02691793_exc_T8",
"type": "Mood",
"text": [
"treated"
],
"offsets": [
[
55,
62
]
],
"normalized": []
},
{
"id": "NCT02691793_exc_T9",
"type": "Mood",
"text": [
"treated"
],
"offsets": [
[
100,
107
]
],
"normalized": []
},
{
"id": "NCT02691793_exc_T10",
"type": "Scope",
"text": [
"treated non-melanoma skin cancer, curatively treated in-situ cancer of the cervix"
],
"offsets": [
[
55,
136
]
],
"normalized": []
},
{
"id": "NCT02691793_exc_T11",
"type": "Condition",
"text": [
"metastases"
],
"offsets": [
[
267,
277
]
],
"normalized": []
},
{
"id": "NCT02691793_exc_T12",
"type": "Qualifier",
"text": [
"central nervous system"
],
"offsets": [
[
239,
261
]
],
"normalized": []
},
{
"id": "NCT02691793_exc_T13",
"type": "Qualifier",
"text": [
"CNS"
],
"offsets": [
[
262,
265
]
],
"normalized": []
},
{
"id": "NCT02691793_exc_T14",
"type": "Condition",
"text": [
"active infection"
],
"offsets": [
[
285,
301
]
],
"normalized": []
},
{
"id": "NCT02691793_exc_T16",
"type": "Condition",
"text": [
"cardiac problem"
],
"offsets": [
[
371,
386
]
],
"normalized": []
},
{
"id": "NCT02691793_exc_T17",
"type": "Drug",
"text": [
"sunitinib"
],
"offsets": [
[
415,
424
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02691793_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02691793_exc_T2",
"arg2_id": "NCT02691793_exc_T1",
"normalized": []
},
{
"id": "NCT02691793_exc_R2",
"type": "Has_mood",
"arg1_id": "NCT02691793_exc_T4",
"arg2_id": "NCT02691793_exc_T8",
"normalized": []
},
{
"id": "NCT02691793_exc_R3",
"type": "Has_mood",
"arg1_id": "NCT02691793_exc_T5",
"arg2_id": "NCT02691793_exc_T9",
"normalized": []
},
{
"id": "NCT02691793_exc_R4",
"type": "Has_negation",
"arg1_id": "NCT02691793_exc_T10",
"arg2_id": "NCT02691793_exc_T3",
"normalized": []
},
{
"id": "NCT02691793_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT02691793_exc_T12",
"arg2_id": "NCT02691793_exc_T13",
"normalized": []
},
{
"id": "NCT02691793_exc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT02691793_exc_T11",
"arg2_id": "NCT02691793_exc_T12",
"normalized": []
}
] |
NCT02691793_inc
|
NCT02691793
|
[
{
"id": "NCT02691793_inc_text",
"type": "inclusion",
"text": [
"Provision of fully informed consent prior to study specific procedures.\nPatients must be >= 19 years of age\nRET fusion positive or FGFR2 fusion/other FGFR mutation Refractory solid tumor and/or specific sensitivity to Sunitinib by Avatar scan that has progressed following standard therapy or that has not responded to standard therapy or for which there is no standard therapy.\nECOG Performance status0-2\nHave measurable or evaluated disease based on RECIST 1.1 as determined by investigator.\nAbsolute neutrophil count >= 1.5 x 109/L, Hemoglobin >= 9g/dL, Platelets>=100 x 109/L Bilirubin <= 1.5 x upper limit of normal AST/ALT <= 2.5 X upper limit of normal(5.0 x upper limit of normal, for subject with liver metastases) Creatinine<= 1.5 X UNL\nPatients of child-bearing potential should be using adequate contraceptive measures should not be breast feeding and must have a negative pregnancy test prior to start of dosing\nAdequate heart function\n"
],
"offsets": [
[
0,
949
]
]
}
] |
[
{
"id": "NCT02691793_inc_T2",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
104,
107
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T3",
"type": "Value",
"text": [
">= 19 years"
],
"offsets": [
[
89,
100
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T4",
"type": "Measurement",
"text": [
"RET fusion"
],
"offsets": [
[
108,
118
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T5",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
119,
127
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T6",
"type": "Qualifier",
"text": [
"FGFR2 fusion"
],
"offsets": [
[
131,
143
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T7",
"type": "Qualifier",
"text": [
"FGFR mutation"
],
"offsets": [
[
150,
163
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T8",
"type": "Qualifier",
"text": [
"Refractory"
],
"offsets": [
[
164,
174
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T9",
"type": "Condition",
"text": [
"solid tumor"
],
"offsets": [
[
175,
186
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T10",
"type": "Scope",
"text": [
"FGFR2 fusion/other FGFR mutation"
],
"offsets": [
[
131,
163
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T11",
"type": "Qualifier",
"text": [
"sensitivity"
],
"offsets": [
[
203,
214
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T12",
"type": "Drug",
"text": [
"Sunitinib"
],
"offsets": [
[
218,
227
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T14",
"type": "Measurement",
"text": [
"ECOG Performance status"
],
"offsets": [
[
379,
402
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T15",
"type": "Value",
"text": [
"0-2"
],
"offsets": [
[
402,
405
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T17",
"type": "Measurement",
"text": [
"Absolute neutrophil count"
],
"offsets": [
[
494,
519
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T18",
"type": "Value",
"text": [
">= 1.5 x 109/L"
],
"offsets": [
[
520,
534
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T19",
"type": "Measurement",
"text": [
"Hemoglobin"
],
"offsets": [
[
536,
546
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T20",
"type": "Value",
"text": [
">= 9g/dL,"
],
"offsets": [
[
547,
556
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T21",
"type": "Measurement",
"text": [
"Platelets"
],
"offsets": [
[
557,
566
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T22",
"type": "Value",
"text": [
">=100 x 109/L"
],
"offsets": [
[
566,
579
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T23",
"type": "Measurement",
"text": [
"Bilirubin"
],
"offsets": [
[
580,
589
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T24",
"type": "Value",
"text": [
"<= 1.5 x upper limit of normal"
],
"offsets": [
[
590,
620
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T25",
"type": "Measurement",
"text": [
"AST"
],
"offsets": [
[
621,
624
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T26",
"type": "Measurement",
"text": [
"ALT"
],
"offsets": [
[
625,
628
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T27",
"type": "Value",
"text": [
"<= 2.5 X upper limit of normal("
],
"offsets": [
[
629,
660
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T28",
"type": "Condition",
"text": [
"liver metastases"
],
"offsets": [
[
706,
722
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T29",
"type": "Value",
"text": [
"5.0 x upper limit of normal"
],
"offsets": [
[
660,
687
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T30",
"type": "Measurement",
"text": [
"Creatinine"
],
"offsets": [
[
724,
734
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T31",
"type": "Value",
"text": [
"<= 1.5 X UNL"
],
"offsets": [
[
734,
746
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T32",
"type": "Measurement",
"text": [
"AST"
],
"offsets": [
[
621,
624
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T33",
"type": "Measurement",
"text": [
"ALT"
],
"offsets": [
[
625,
628
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T34",
"type": "Condition",
"text": [
"Adequate heart function"
],
"offsets": [
[
925,
948
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T35",
"type": "Measurement",
"text": [
"heart function"
],
"offsets": [
[
934,
948
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T36",
"type": "Value",
"text": [
"Adequate"
],
"offsets": [
[
925,
933
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T37",
"type": "Observation",
"text": [
"child-bearing potential"
],
"offsets": [
[
759,
782
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T38",
"type": "Procedure",
"text": [
"adequate contraceptive measures"
],
"offsets": [
[
799,
830
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T39",
"type": "Negation",
"text": [
"not be"
],
"offsets": [
[
838,
844
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T40",
"type": "Condition",
"text": [
"breast feeding"
],
"offsets": [
[
845,
859
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T41",
"type": "Value",
"text": [
"negative"
],
"offsets": [
[
876,
884
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T42",
"type": "Measurement",
"text": [
"pregnancy test"
],
"offsets": [
[
885,
899
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T43",
"type": "Temporal",
"text": [
"prior to start of dosing"
],
"offsets": [
[
900,
924
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T44",
"type": "Reference_point",
"text": [
"start of dosing"
],
"offsets": [
[
909,
924
]
],
"normalized": []
},
{
"id": "NCT02691793_inc_T45",
"type": "Scope",
"text": [
"adequate contraceptive measures should not be breast feeding and must have a negative pregnancy test prior to start of dosing"
],
"offsets": [
[
799,
924
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02691793_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02691793_inc_T2",
"arg2_id": "NCT02691793_inc_T3",
"normalized": []
},
{
"id": "NCT02691793_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02691793_inc_T4",
"arg2_id": "NCT02691793_inc_T5",
"normalized": []
},
{
"id": "NCT02691793_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02691793_inc_T9",
"arg2_id": "NCT02691793_inc_T8",
"normalized": []
},
{
"id": "NCT02691793_inc_R4",
"type": "Has_scope",
"arg1_id": "NCT02691793_inc_T9",
"arg2_id": "NCT02691793_inc_T10",
"normalized": []
},
{
"id": "NCT02691793_inc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02691793_inc_T12",
"arg2_id": "NCT02691793_inc_T11",
"normalized": []
},
{
"id": "NCT02691793_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02691793_inc_T14",
"arg2_id": "NCT02691793_inc_T15",
"normalized": []
},
{
"id": "NCT02691793_inc_R7",
"type": "Has_value",
"arg1_id": "NCT02691793_inc_T17",
"arg2_id": "NCT02691793_inc_T18",
"normalized": []
},
{
"id": "NCT02691793_inc_R8",
"type": "Has_value",
"arg1_id": "NCT02691793_inc_T19",
"arg2_id": "NCT02691793_inc_T20",
"normalized": []
},
{
"id": "NCT02691793_inc_R9",
"type": "Has_value",
"arg1_id": "NCT02691793_inc_T21",
"arg2_id": "NCT02691793_inc_T22",
"normalized": []
},
{
"id": "NCT02691793_inc_R10",
"type": "Has_value",
"arg1_id": "NCT02691793_inc_T23",
"arg2_id": "NCT02691793_inc_T24",
"normalized": []
},
{
"id": "NCT02691793_inc_R11",
"type": "Has_value",
"arg1_id": "NCT02691793_inc_T25",
"arg2_id": "NCT02691793_inc_T27",
"normalized": []
},
{
"id": "NCT02691793_inc_R12",
"type": "Has_value",
"arg1_id": "NCT02691793_inc_T26",
"arg2_id": "NCT02691793_inc_T27",
"normalized": []
},
{
"id": "NCT02691793_inc_R13",
"type": "AND",
"arg1_id": "NCT02691793_inc_T28",
"arg2_id": "NCT02691793_inc_T32",
"normalized": []
},
{
"id": "NCT02691793_inc_R14",
"type": "AND",
"arg1_id": "NCT02691793_inc_T28",
"arg2_id": "NCT02691793_inc_T33",
"normalized": []
},
{
"id": "NCT02691793_inc_R15",
"type": "Has_value",
"arg1_id": "NCT02691793_inc_T32",
"arg2_id": "NCT02691793_inc_T29",
"normalized": []
},
{
"id": "NCT02691793_inc_R16",
"type": "Has_value",
"arg1_id": "NCT02691793_inc_T33",
"arg2_id": "NCT02691793_inc_T29",
"normalized": []
},
{
"id": "NCT02691793_inc_R17",
"type": "Has_value",
"arg1_id": "NCT02691793_inc_T30",
"arg2_id": "NCT02691793_inc_T31",
"normalized": []
},
{
"id": "NCT02691793_inc_R18",
"type": "Has_value",
"arg1_id": "NCT02691793_inc_T35",
"arg2_id": "NCT02691793_inc_T36",
"normalized": []
},
{
"id": "NCT02691793_inc_R20",
"type": "Has_index",
"arg1_id": "NCT02691793_inc_T43",
"arg2_id": "NCT02691793_inc_T44",
"normalized": []
},
{
"id": "NCT02691793_inc_R21",
"type": "Has_temporal",
"arg1_id": "NCT02691793_inc_T42",
"arg2_id": "NCT02691793_inc_T43",
"normalized": []
},
{
"id": "NCT02691793_inc_R22",
"type": "Has_value",
"arg1_id": "NCT02691793_inc_T42",
"arg2_id": "NCT02691793_inc_T41",
"normalized": []
},
{
"id": "NCT02691793_inc_R23",
"type": "Has_negation",
"arg1_id": "NCT02691793_inc_T40",
"arg2_id": "NCT02691793_inc_T39",
"normalized": []
},
{
"id": "NCT02691793_inc_R24",
"type": "Has_scope",
"arg1_id": "NCT02691793_inc_T37",
"arg2_id": "NCT02691793_inc_T45",
"normalized": []
}
] |
NCT02692651_exc
|
NCT02692651
|
[
{
"id": "NCT02692651_exc_text",
"type": "exclusion",
"text": [
"Patients with severe-complicated disease that would compromise oral therapy (hypotenstion or shock, ileus or bowel obstruction, megacolon).\nPatients with an allergy to oral vancomycin or fidaxomicin.\nPatients anticipated to receive metronidazole after enrollment.\nPatients who already received oral vancomycin or metronidazole (either oral or intravenous) for > 24 hours within the preceding 72 hours at the time of enrollment.\nPatients anticipated to receive adjunctive C. difficile therapy (rifaxamin, nitazoxanide, tigecycline) after enrollment.\n"
],
"offsets": [
[
0,
549
]
]
}
] |
[
{
"id": "NCT02692651_exc_T1",
"type": "Condition",
"text": [
"hypotenstion"
],
"offsets": [
[
77,
89
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T2",
"type": "Condition",
"text": [
"shock"
],
"offsets": [
[
93,
98
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T3",
"type": "Condition",
"text": [
"ileus"
],
"offsets": [
[
100,
105
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T4",
"type": "Condition",
"text": [
"bowel obstruction"
],
"offsets": [
[
109,
126
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T5",
"type": "Condition",
"text": [
"megacolon"
],
"offsets": [
[
128,
137
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T7",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
157,
164
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T8",
"type": "Drug",
"text": [
"vancomycin"
],
"offsets": [
[
173,
183
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T9",
"type": "Drug",
"text": [
"fidaxomicin"
],
"offsets": [
[
187,
198
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T10",
"type": "Qualifier",
"text": [
"oral"
],
"offsets": [
[
168,
172
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T11",
"type": "Scope",
"text": [
"vancomycin or fidaxomicin"
],
"offsets": [
[
173,
198
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T12",
"type": "Drug",
"text": [
"metronidazole"
],
"offsets": [
[
232,
245
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T13",
"type": "Mood",
"text": [
"anticipated"
],
"offsets": [
[
209,
220
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T14",
"type": "Drug",
"text": [
"vancomycin"
],
"offsets": [
[
299,
309
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T15",
"type": "Drug",
"text": [
"metronidazole"
],
"offsets": [
[
313,
326
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T16",
"type": "Qualifier",
"text": [
"oral"
],
"offsets": [
[
294,
298
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T17",
"type": "Multiplier",
"text": [
"> 24 hours"
],
"offsets": [
[
360,
370
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T18",
"type": "Temporal",
"text": [
"preceding 72 hours at the time of enrollment."
],
"offsets": [
[
382,
427
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T19",
"type": "Reference_point",
"text": [
"enrollment"
],
"offsets": [
[
416,
426
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T20",
"type": "Scope",
"text": [
"oral vancomycin or metronidazole"
],
"offsets": [
[
294,
326
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T21",
"type": "Mood",
"text": [
"anticipated"
],
"offsets": [
[
437,
448
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T22",
"type": "Procedure",
"text": [
"C. difficile therapy"
],
"offsets": [
[
471,
491
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T23",
"type": "Drug",
"text": [
"rifaxamin"
],
"offsets": [
[
493,
502
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T24",
"type": "Drug",
"text": [
"nitazoxanide"
],
"offsets": [
[
504,
516
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T25",
"type": "Drug",
"text": [
"tigecycline"
],
"offsets": [
[
518,
529
]
],
"normalized": []
},
{
"id": "NCT02692651_exc_T26",
"type": "Scope",
"text": [
"rifaxamin, nitazoxanide, tigecycline)"
],
"offsets": [
[
493,
530
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02692651_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02692651_exc_T8",
"arg2_id": "NCT02692651_exc_T10",
"normalized": []
},
{
"id": "NCT02692651_exc_R2",
"type": "Has_scope",
"arg1_id": "NCT02692651_exc_T7",
"arg2_id": "NCT02692651_exc_T11",
"normalized": []
},
{
"id": "NCT02692651_exc_R3",
"type": "Has_mood",
"arg1_id": "NCT02692651_exc_T12",
"arg2_id": "NCT02692651_exc_T13",
"normalized": []
},
{
"id": "NCT02692651_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02692651_exc_T14",
"arg2_id": "NCT02692651_exc_T16",
"normalized": []
},
{
"id": "NCT02692651_exc_R5",
"type": "Has_index",
"arg1_id": "NCT02692651_exc_T18",
"arg2_id": "NCT02692651_exc_T19",
"normalized": []
},
{
"id": "NCT02692651_exc_R6",
"type": "Has_multiplier",
"arg1_id": "NCT02692651_exc_T20",
"arg2_id": "NCT02692651_exc_T17",
"normalized": []
},
{
"id": "NCT02692651_exc_R7",
"type": "Subsumes",
"arg1_id": "NCT02692651_exc_T22",
"arg2_id": "NCT02692651_exc_T26",
"normalized": []
},
{
"id": "NCT02692651_exc_R8",
"type": "Has_mood",
"arg1_id": "NCT02692651_exc_T22",
"arg2_id": "NCT02692651_exc_T21",
"normalized": []
}
] |
NCT02692651_inc
|
NCT02692651
|
[
{
"id": "NCT02692651_inc_text",
"type": "inclusion",
"text": [
"Patients 18 years of age or older with >3 unformed stools/24 hours with positive stool test for C. difficile.\nPatients receiving = 1 high or medium risk antibiotic for treatment of an infection other than CDI, for an anticipated duration of = 5 days from the time of enrollment.\n"
],
"offsets": [
[
0,
279
]
]
}
] |
[
{
"id": "NCT02692651_inc_T1",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
21,
24
]
],
"normalized": []
},
{
"id": "NCT02692651_inc_T2",
"type": "Value",
"text": [
"or older",
"18 years"
],
"offsets": [
[
25,
33
],
[
9,
17
]
],
"normalized": []
},
{
"id": "NCT02692651_inc_T3",
"type": "Multiplier",
"text": [
">3"
],
"offsets": [
[
39,
41
]
],
"normalized": []
},
{
"id": "NCT02692651_inc_T4",
"type": "Observation",
"text": [
"unformed stools"
],
"offsets": [
[
42,
57
]
],
"normalized": []
},
{
"id": "NCT02692651_inc_T5",
"type": "Temporal",
"text": [
"24 hours"
],
"offsets": [
[
58,
66
]
],
"normalized": []
},
{
"id": "NCT02692651_inc_T6",
"type": "Measurement",
"text": [
"stool test"
],
"offsets": [
[
81,
91
]
],
"normalized": []
},
{
"id": "NCT02692651_inc_T7",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
72,
80
]
],
"normalized": []
},
{
"id": "NCT02692651_inc_T8",
"type": "Qualifier",
"text": [
"C. difficile"
],
"offsets": [
[
96,
108
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02692651_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02692651_inc_T1",
"arg2_id": "NCT02692651_inc_T2",
"normalized": []
},
{
"id": "NCT02692651_inc_R2",
"type": "Has_multiplier",
"arg1_id": "NCT02692651_inc_T4",
"arg2_id": "NCT02692651_inc_T3",
"normalized": []
},
{
"id": "NCT02692651_inc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02692651_inc_T4",
"arg2_id": "NCT02692651_inc_T5",
"normalized": []
},
{
"id": "NCT02692651_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02692651_inc_T6",
"arg2_id": "NCT02692651_inc_T7",
"normalized": []
},
{
"id": "NCT02692651_inc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02692651_inc_T6",
"arg2_id": "NCT02692651_inc_T8",
"normalized": []
}
] |
NCT02695992_exc
|
NCT02695992
|
[
{
"id": "NCT02695992_exc_text",
"type": "exclusion",
"text": [
"Congestive heart failure\nIschemic heart disease\nHypotension (Systolic blood pressure <100 mmHg)\nTreatment with class I or III antiarrhythmic drugs\nSevere hepatic or renal failure\nPregnancy or lactation\nHypersensitivity or contradictions to study drugs\nAtrio-ventricular conduction disturbances\nThyrotoxicosis\nLife limiting disease or substance abuse which may affect participation\n"
],
"offsets": [
[
0,
381
]
]
}
] |
[
{
"id": "NCT02695992_exc_T1",
"type": "Condition",
"text": [
"Congestive heart failure"
],
"offsets": [
[
0,
24
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T2",
"type": "Condition",
"text": [
"Ischemic heart disease"
],
"offsets": [
[
25,
47
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T3",
"type": "Condition",
"text": [
"Hypotension"
],
"offsets": [
[
48,
59
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T4",
"type": "Measurement",
"text": [
"Systolic blood pressure"
],
"offsets": [
[
61,
84
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T5",
"type": "Value",
"text": [
"<100 mmHg"
],
"offsets": [
[
85,
94
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T6",
"type": "Scope",
"text": [
"Systolic blood pressure <100 mmHg"
],
"offsets": [
[
61,
94
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T7",
"type": "Qualifier",
"text": [
"class I"
],
"offsets": [
[
111,
118
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T8",
"type": "Qualifier",
"text": [
"ss I",
" a"
],
"offsets": [
[
114,
118
],
[
125,
127
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T9",
"type": "Drug",
"text": [
"antiarrhythmic drugs"
],
"offsets": [
[
126,
146
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T10",
"type": "Scope",
"text": [
"class I or III"
],
"offsets": [
[
111,
125
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T11",
"type": "Qualifier",
"text": [
"Severe"
],
"offsets": [
[
147,
153
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T12",
"type": "Condition",
"text": [
"renal failure"
],
"offsets": [
[
165,
178
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T13",
"type": "Condition",
"text": [
"tic or",
"ure\nPre"
],
"offsets": [
[
158,
164
],
[
175,
182
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T15",
"type": "Scope",
"text": [
"hepatic or renal failure"
],
"offsets": [
[
154,
178
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T16",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
179,
188
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T17",
"type": "Condition",
"text": [
"lactation"
],
"offsets": [
[
192,
201
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T18",
"type": "Condition",
"text": [
"Hypersensitivity"
],
"offsets": [
[
202,
218
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T19",
"type": "Condition",
"text": [
"contradictions"
],
"offsets": [
[
222,
236
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T20",
"type": "Drug",
"text": [
"study drugs"
],
"offsets": [
[
240,
251
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T21",
"type": "Scope",
"text": [
"Hypersensitivity or contradictions"
],
"offsets": [
[
202,
236
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T23",
"type": "Condition",
"text": [
"Thyrotoxicosis"
],
"offsets": [
[
294,
308
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T24",
"type": "Condition",
"text": [
"Atrio-ventricular conduction disturbances"
],
"offsets": [
[
252,
293
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T25",
"type": "Condition",
"text": [
"Life limiting disease"
],
"offsets": [
[
309,
330
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T26",
"type": "Condition",
"text": [
"substance abuse"
],
"offsets": [
[
334,
349
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T27",
"type": "Qualifier",
"text": [
"may affect participation"
],
"offsets": [
[
356,
380
]
],
"normalized": []
},
{
"id": "NCT02695992_exc_T28",
"type": "Scope",
"text": [
"Life limiting disease or substance abuse"
],
"offsets": [
[
309,
349
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02695992_exc_R1",
"type": "Has_value",
"arg1_id": "NCT02695992_exc_T4",
"arg2_id": "NCT02695992_exc_T5",
"normalized": []
},
{
"id": "NCT02695992_exc_R2",
"type": "Subsumes",
"arg1_id": "NCT02695992_exc_T3",
"arg2_id": "NCT02695992_exc_T6",
"normalized": []
},
{
"id": "NCT02695992_exc_R3",
"type": "Has_scope",
"arg1_id": "NCT02695992_exc_T9",
"arg2_id": "NCT02695992_exc_T10",
"normalized": []
},
{
"id": "NCT02695992_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02695992_exc_T15",
"arg2_id": "NCT02695992_exc_T11",
"normalized": []
},
{
"id": "NCT02695992_exc_R6",
"type": "AND",
"arg1_id": "NCT02695992_exc_T21",
"arg2_id": "NCT02695992_exc_T20",
"normalized": []
},
{
"id": "NCT02695992_exc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02695992_exc_T28",
"arg2_id": "NCT02695992_exc_T27",
"normalized": []
}
] |
NCT02695992_inc
|
NCT02695992
|
[
{
"id": "NCT02695992_inc_text",
"type": "inclusion",
"text": [
"Above 18 years of age\nSymptomatic, permanent AF of at least three months duration\nResting heart rate =80 bpm\nSigned informed consent\n"
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "NCT02695992_inc_T1",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "NCT02695992_inc_T2",
"type": "Value",
"text": [
"Above 18 years"
],
"offsets": [
[
0,
14
]
],
"normalized": []
},
{
"id": "NCT02695992_inc_T3",
"type": "Qualifier",
"text": [
"Symptomatic"
],
"offsets": [
[
22,
33
]
],
"normalized": []
},
{
"id": "NCT02695992_inc_T4",
"type": "Qualifier",
"text": [
"permanent"
],
"offsets": [
[
35,
44
]
],
"normalized": []
},
{
"id": "NCT02695992_inc_T5",
"type": "Condition",
"text": [
"AF"
],
"offsets": [
[
45,
47
]
],
"normalized": []
},
{
"id": "NCT02695992_inc_T6",
"type": "Multiplier",
"text": [
"at least three months duration"
],
"offsets": [
[
51,
81
]
],
"normalized": []
},
{
"id": "NCT02695992_inc_T7",
"type": "Scope",
"text": [
"Symptomatic, permanent"
],
"offsets": [
[
22,
44
]
],
"normalized": []
},
{
"id": "NCT02695992_inc_T8",
"type": "Measurement",
"text": [
"Resting heart rate"
],
"offsets": [
[
82,
100
]
],
"normalized": []
},
{
"id": "NCT02695992_inc_T9",
"type": "Value",
"text": [
"=80 bpm"
],
"offsets": [
[
101,
108
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02695992_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02695992_inc_T1",
"arg2_id": "NCT02695992_inc_T2",
"normalized": []
},
{
"id": "NCT02695992_inc_R2",
"type": "Has_multiplier",
"arg1_id": "NCT02695992_inc_T5",
"arg2_id": "NCT02695992_inc_T6",
"normalized": []
},
{
"id": "NCT02695992_inc_R3",
"type": "Has_scope",
"arg1_id": "NCT02695992_inc_T5",
"arg2_id": "NCT02695992_inc_T7",
"normalized": []
},
{
"id": "NCT02695992_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02695992_inc_T8",
"arg2_id": "NCT02695992_inc_T9",
"normalized": []
}
] |
NCT02698969_exc
|
NCT02698969
|
[
{
"id": "NCT02698969_exc_text",
"type": "exclusion",
"text": [
"Clinical diagnosis of hepatic or renal disease\nClinical diagnosis of chronic or acute alcoholism\nHistory of allergy or hypersensitivity to Sugammadex and/or atropine or Neostigmine\nCurrent medications with CNS effects\nHistory of neurologic disease\nDiaphragmatic palsy\nPregnancy or nursing\nHistory of malignant arrhythmias\n"
],
"offsets": [
[
0,
322
]
]
}
] |
[
{
"id": "NCT02698969_exc_T1",
"type": "Condition",
"text": [
"renal disease"
],
"offsets": [
[
33,
46
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T2",
"type": "Condition",
"text": [
"hepatic",
"disease"
],
"offsets": [
[
22,
29
],
[
39,
46
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T3",
"type": "Qualifier",
"text": [
"Clinical diagnosis"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T4",
"type": "Qualifier",
"text": [
"Clinical diagnosis"
],
"offsets": [
[
47,
65
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T5",
"type": "Qualifier",
"text": [
"acute"
],
"offsets": [
[
80,
85
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T6",
"type": "Qualifier",
"text": [
"chronic"
],
"offsets": [
[
69,
76
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T7",
"type": "Condition",
"text": [
"alcoholism"
],
"offsets": [
[
86,
96
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T8",
"type": "Scope",
"text": [
"chronic or acute"
],
"offsets": [
[
69,
85
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T9",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
108,
115
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T10",
"type": "Condition",
"text": [
"hypersensitivity"
],
"offsets": [
[
119,
135
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T11",
"type": "Drug",
"text": [
"Sugammadex"
],
"offsets": [
[
139,
149
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T12",
"type": "Drug",
"text": [
"atropine"
],
"offsets": [
[
157,
165
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T13",
"type": "Drug",
"text": [
"Neostigmine"
],
"offsets": [
[
169,
180
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T14",
"type": "Scope",
"text": [
"Sugammadex and/or atropine or Neostigmine"
],
"offsets": [
[
139,
180
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T15",
"type": "Scope",
"text": [
"allergy or hypersensitivity"
],
"offsets": [
[
108,
135
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T16",
"type": "Condition",
"text": [
"CNS effects"
],
"offsets": [
[
206,
217
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T17",
"type": "Drug",
"text": [
"medications"
],
"offsets": [
[
189,
200
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T18",
"type": "Condition",
"text": [
"neurologic disease"
],
"offsets": [
[
229,
247
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T19",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
218,
225
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T20",
"type": "Condition",
"text": [
"Diaphragmatic palsy"
],
"offsets": [
[
248,
267
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T21",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
268,
277
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T22",
"type": "Condition",
"text": [
"nursing"
],
"offsets": [
[
281,
288
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T23",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
289,
296
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T24",
"type": "Condition",
"text": [
"malignant arrhythmias"
],
"offsets": [
[
300,
321
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T25",
"type": "Scope",
"text": [
"hepatic or renal disease"
],
"offsets": [
[
22,
46
]
],
"normalized": []
},
{
"id": "NCT02698969_exc_T26",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
97,
104
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02698969_exc_R1",
"type": "Has_scope",
"arg1_id": "NCT02698969_exc_T7",
"arg2_id": "NCT02698969_exc_T8",
"normalized": []
},
{
"id": "NCT02698969_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02698969_exc_T7",
"arg2_id": "NCT02698969_exc_T4",
"normalized": []
},
{
"id": "NCT02698969_exc_R3",
"type": "Has_scope",
"arg1_id": "NCT02698969_exc_T15",
"arg2_id": "NCT02698969_exc_T14",
"normalized": []
},
{
"id": "NCT02698969_exc_R4",
"type": "AND",
"arg1_id": "NCT02698969_exc_T17",
"arg2_id": "NCT02698969_exc_T16",
"normalized": []
},
{
"id": "NCT02698969_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02698969_exc_T18",
"arg2_id": "NCT02698969_exc_T19",
"normalized": []
},
{
"id": "NCT02698969_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02698969_exc_T24",
"arg2_id": "NCT02698969_exc_T23",
"normalized": []
},
{
"id": "NCT02698969_exc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02698969_exc_T25",
"arg2_id": "NCT02698969_exc_T3",
"normalized": []
},
{
"id": "NCT02698969_exc_R8",
"type": "Has_temporal",
"arg1_id": "NCT02698969_exc_T15",
"arg2_id": "NCT02698969_exc_T26",
"normalized": []
}
] |
NCT02698969_inc
|
NCT02698969
|
[
{
"id": "NCT02698969_inc_text",
"type": "inclusion",
"text": [
"ASA physical status I-II\nage between 18-80 years old\ndNMB with rocuronium during ear nose and throat (ENT) surgery\n"
],
"offsets": [
[
0,
115
]
]
}
] |
[
{
"id": "NCT02698969_inc_T1",
"type": "Measurement",
"text": [
"ASA physical status"
],
"offsets": [
[
0,
19
]
],
"normalized": []
},
{
"id": "NCT02698969_inc_T2",
"type": "Value",
"text": [
"I-II"
],
"offsets": [
[
20,
24
]
],
"normalized": []
},
{
"id": "NCT02698969_inc_T3",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
25,
28
]
],
"normalized": []
},
{
"id": "NCT02698969_inc_T4",
"type": "Value",
"text": [
"between 18-80 years"
],
"offsets": [
[
29,
48
]
],
"normalized": []
},
{
"id": "NCT02698969_inc_T5",
"type": "Drug",
"text": [
"dNMB with rocuronium"
],
"offsets": [
[
53,
73
]
],
"normalized": []
},
{
"id": "NCT02698969_inc_T6",
"type": "Procedure",
"text": [
"ear nose and throat (ENT) surgery"
],
"offsets": [
[
81,
114
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02698969_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02698969_inc_T1",
"arg2_id": "NCT02698969_inc_T2",
"normalized": []
},
{
"id": "NCT02698969_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02698969_inc_T3",
"arg2_id": "NCT02698969_inc_T4",
"normalized": []
},
{
"id": "NCT02698969_inc_R3",
"type": "AND",
"arg1_id": "NCT02698969_inc_T6",
"arg2_id": "NCT02698969_inc_T5",
"normalized": []
}
] |
NCT02701777_exc
|
NCT02701777
|
[
{
"id": "NCT02701777_exc_text",
"type": "exclusion",
"text": [
"Uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease\nAny debilitating disease prior to the SCI that caused exercise intolerance\nPremorbid, ongoing major depression or psychosis, altered cognitive status\nHistory of head injury or stroke\nMetal plate in skull\nHistory of seizures\nReceiving drugs acting primarily on the central nervous system, which lower the seizure threshold (see appendix 2)\nPregnant females\nOngoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida, MS, or herniated disk\nIndividuals with scalp shrapnel, cochlear implants, or aneurysm clips.\n"
],
"offsets": [
[
0,
673
]
]
}
] |
[
{
"id": "NCT02701777_exc_T1",
"type": "Qualifier",
"text": [
"Uncontrolled"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T2",
"type": "Condition",
"text": [
"medical problems"
],
"offsets": [
[
13,
29
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T3",
"type": "Condition",
"text": [
"pulmonary",
"disease"
],
"offsets": [
[
40,
49
],
[
80,
87
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T4",
"type": "Condition",
"text": [
"cardiovascular",
"disease"
],
"offsets": [
[
51,
65
],
[
80,
87
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T5",
"type": "Condition",
"text": [
"orthopedic disease"
],
"offsets": [
[
69,
87
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T6",
"type": "Scope",
"text": [
"pulmonary, cardiovascular or orthopedic disease"
],
"offsets": [
[
40,
87
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T7",
"type": "Condition",
"text": [
"exercise intolerance"
],
"offsets": [
[
142,
162
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T8",
"type": "Condition",
"text": [
"debilitating disease"
],
"offsets": [
[
92,
112
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T9",
"type": "Temporal",
"text": [
"prior to the SCI"
],
"offsets": [
[
113,
129
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T10",
"type": "Reference_point",
"text": [
"the SCI"
],
"offsets": [
[
122,
129
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T11",
"type": "Qualifier",
"text": [
"Premorbid"
],
"offsets": [
[
163,
172
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T12",
"type": "Temporal",
"text": [
"ongoing"
],
"offsets": [
[
174,
181
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T13",
"type": "Condition",
"text": [
"major depression"
],
"offsets": [
[
182,
198
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T14",
"type": "Condition",
"text": [
"psychosis"
],
"offsets": [
[
202,
211
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T15",
"type": "Condition",
"text": [
"altered cognitive status"
],
"offsets": [
[
213,
237
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T16",
"type": "Scope",
"text": [
"major depression or psychosis"
],
"offsets": [
[
182,
211
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T17",
"type": "Condition",
"text": [
"head injury"
],
"offsets": [
[
249,
260
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T18",
"type": "Condition",
"text": [
"stroke"
],
"offsets": [
[
264,
270
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T19",
"type": "Device",
"text": [
"Metal plate in skull"
],
"offsets": [
[
271,
291
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T20",
"type": "Condition",
"text": [
"seizures"
],
"offsets": [
[
303,
311
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T21",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
238,
245
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T22",
"type": "Scope",
"text": [
"head injury or stroke"
],
"offsets": [
[
249,
270
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T23",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
292,
299
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T24",
"type": "Drug",
"text": [
"drugs acting primarily on the central nervous system"
],
"offsets": [
[
322,
374
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T25",
"type": "Qualifier",
"text": [
"lower the seizure threshold"
],
"offsets": [
[
382,
409
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T26",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
427,
435
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T27",
"type": "Person",
"text": [
"females"
],
"offsets": [
[
436,
443
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T28",
"type": "Condition",
"text": [
"cord compression"
],
"offsets": [
[
452,
468
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T29",
"type": "Condition",
"text": [
"syrinx"
],
"offsets": [
[
474,
480
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T30",
"type": "Qualifier",
"text": [
"spinal cord"
],
"offsets": [
[
488,
499
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T31",
"type": "Condition",
"text": [
"spinal stenosis"
],
"offsets": [
[
549,
564
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T32",
"type": "Condition",
"text": [
"spinal cord disease"
],
"offsets": [
[
521,
540
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T33",
"type": "Condition",
"text": [
"spina bifida"
],
"offsets": [
[
566,
578
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T34",
"type": "Condition",
"text": [
"MS"
],
"offsets": [
[
580,
582
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T35",
"type": "Condition",
"text": [
"herniated disk"
],
"offsets": [
[
587,
601
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T36",
"type": "Scope",
"text": [
"spinal stenosis, spina bifida, MS, or herniated disk"
],
"offsets": [
[
549,
601
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T37",
"type": "Device",
"text": [
"scalp shrapnel"
],
"offsets": [
[
619,
633
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T38",
"type": "Device",
"text": [
"cochlear implants"
],
"offsets": [
[
635,
652
]
],
"normalized": []
},
{
"id": "NCT02701777_exc_T39",
"type": "Device",
"text": [
"aneurysm clips"
],
"offsets": [
[
657,
671
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02701777_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT02701777_exc_T2",
"arg2_id": "NCT02701777_exc_T6",
"normalized": []
},
{
"id": "NCT02701777_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02701777_exc_T2",
"arg2_id": "NCT02701777_exc_T1",
"normalized": []
},
{
"id": "NCT02701777_exc_R3",
"type": "Has_index",
"arg1_id": "NCT02701777_exc_T9",
"arg2_id": "NCT02701777_exc_T10",
"normalized": []
},
{
"id": "NCT02701777_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02701777_exc_T8",
"arg2_id": "NCT02701777_exc_T9",
"normalized": []
},
{
"id": "NCT02701777_exc_R5",
"type": "AND",
"arg1_id": "NCT02701777_exc_T8",
"arg2_id": "NCT02701777_exc_T7",
"normalized": []
},
{
"id": "NCT02701777_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02701777_exc_T16",
"arg2_id": "NCT02701777_exc_T12",
"normalized": []
},
{
"id": "NCT02701777_exc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02701777_exc_T16",
"arg2_id": "NCT02701777_exc_T11",
"normalized": []
},
{
"id": "NCT02701777_exc_R8",
"type": "Has_temporal",
"arg1_id": "NCT02701777_exc_T22",
"arg2_id": "NCT02701777_exc_T21",
"normalized": []
},
{
"id": "NCT02701777_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT02701777_exc_T20",
"arg2_id": "NCT02701777_exc_T23",
"normalized": []
},
{
"id": "NCT02701777_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT02701777_exc_T24",
"arg2_id": "NCT02701777_exc_T25",
"normalized": []
},
{
"id": "NCT02701777_exc_R11",
"type": "Has_qualifier",
"arg1_id": "NCT02701777_exc_T29",
"arg2_id": "NCT02701777_exc_T30",
"normalized": []
},
{
"id": "NCT02701777_exc_R12",
"type": "Subsumes",
"arg1_id": "NCT02701777_exc_T32",
"arg2_id": "NCT02701777_exc_T36",
"normalized": []
}
] |
NCT02701777_inc
|
NCT02701777
|
[
{
"id": "NCT02701777_inc_text",
"type": "inclusion",
"text": [
"Male and females between ages 18-85 years\nRight handed\nAble to complete precision grips with both hands\nAble to complete full wrist flexion-extension bilaterally\nAble to walk unassisted\nAble to complete full ankle flexion-extension bilaterally\nMale and females between ages 18-85 years\nSCI ( 2 months of injury)\nSpinal Cord injury at or above L5\nThe ability to produce a visible precision grip force with one hand\nAble to perform some small wrist flexion and extension\nThe ability to perform a small visible contraction with dorsiflexion and hip flexor muscles\nNo subjects will be excluded based on their race, religion, ethnicity, gender or HIV status.\nASIA A,B,C, or D\n"
],
"offsets": [
[
0,
671
]
]
}
] |
[
{
"id": "NCT02701777_inc_T1",
"type": "Person",
"text": [
"females"
],
"offsets": [
[
9,
16
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T2",
"type": "Person",
"text": [
"Male"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T3",
"type": "Value",
"text": [
"between",
"18-85 years"
],
"offsets": [
[
17,
24
],
[
30,
41
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T4",
"type": "Person",
"text": [
"ages"
],
"offsets": [
[
25,
29
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T5",
"type": "Condition",
"text": [
"Right handed"
],
"offsets": [
[
42,
54
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T6",
"type": "Procedure",
"text": [
"complete precision grips with both hands"
],
"offsets": [
[
63,
103
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T7",
"type": "Procedure",
"text": [
"complete full wrist flexion-extension bilaterally"
],
"offsets": [
[
112,
161
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T8",
"type": "Procedure",
"text": [
"walk unassisted"
],
"offsets": [
[
170,
185
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T9",
"type": "Mood",
"text": [
"Able to"
],
"offsets": [
[
55,
62
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T10",
"type": "Mood",
"text": [
"Able to"
],
"offsets": [
[
104,
111
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T11",
"type": "Mood",
"text": [
"Able to"
],
"offsets": [
[
162,
169
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T12",
"type": "Mood",
"text": [
"Able to"
],
"offsets": [
[
186,
193
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T13",
"type": "Procedure",
"text": [
"complete full ankle flexion-extension bilaterally"
],
"offsets": [
[
194,
243
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T14",
"type": "Person",
"text": [
"Male"
],
"offsets": [
[
244,
248
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T15",
"type": "Person",
"text": [
"females"
],
"offsets": [
[
253,
260
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T16",
"type": "Value",
"text": [
"n ages",
"years\nSCI ("
],
"offsets": [
[
267,
273
],
[
280,
291
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T17",
"type": "Person",
"text": [
"ages"
],
"offsets": [
[
269,
273
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T18",
"type": "Condition",
"text": [
"SCI"
],
"offsets": [
[
286,
289
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T19",
"type": "Temporal",
"text": [
"2 months of injury"
],
"offsets": [
[
292,
310
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T20",
"type": "Condition",
"text": [
"Spinal Cord injury"
],
"offsets": [
[
312,
330
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T21",
"type": "Qualifier",
"text": [
"at or above L5"
],
"offsets": [
[
331,
345
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T22",
"type": "Procedure",
"text": [
"produce a visible precision grip force with one hand"
],
"offsets": [
[
361,
413
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T23",
"type": "Mood",
"text": [
"The ability to"
],
"offsets": [
[
346,
360
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T24",
"type": "Mood",
"text": [
"Able to"
],
"offsets": [
[
414,
421
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T25",
"type": "Procedure",
"text": [
"small wrist flexion and extension"
],
"offsets": [
[
435,
468
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T26",
"type": "Mood",
"text": [
"The ability to"
],
"offsets": [
[
469,
483
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T27",
"type": "Procedure",
"text": [
"small visible contraction with dorsiflexion and hip flexor muscles"
],
"offsets": [
[
494,
560
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T29",
"type": "Measurement",
"text": [
"ASIA"
],
"offsets": [
[
654,
658
]
],
"normalized": []
},
{
"id": "NCT02701777_inc_T30",
"type": "Value",
"text": [
"A,B,C, or D"
],
"offsets": [
[
659,
670
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02701777_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02701777_inc_T4",
"arg2_id": "NCT02701777_inc_T3",
"normalized": []
},
{
"id": "NCT02701777_inc_R2",
"type": "Has_mood",
"arg1_id": "NCT02701777_inc_T6",
"arg2_id": "NCT02701777_inc_T9",
"normalized": []
},
{
"id": "NCT02701777_inc_R3",
"type": "Has_mood",
"arg1_id": "NCT02701777_inc_T7",
"arg2_id": "NCT02701777_inc_T10",
"normalized": []
},
{
"id": "NCT02701777_inc_R4",
"type": "Has_mood",
"arg1_id": "NCT02701777_inc_T13",
"arg2_id": "NCT02701777_inc_T12",
"normalized": []
},
{
"id": "NCT02701777_inc_R5",
"type": "Has_value",
"arg1_id": "NCT02701777_inc_T17",
"arg2_id": "NCT02701777_inc_T16",
"normalized": []
},
{
"id": "NCT02701777_inc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02701777_inc_T18",
"arg2_id": "NCT02701777_inc_T19",
"normalized": []
},
{
"id": "NCT02701777_inc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02701777_inc_T20",
"arg2_id": "NCT02701777_inc_T21",
"normalized": []
},
{
"id": "NCT02701777_inc_R8",
"type": "Has_mood",
"arg1_id": "NCT02701777_inc_T22",
"arg2_id": "NCT02701777_inc_T23",
"normalized": []
},
{
"id": "NCT02701777_inc_R9",
"type": "Has_mood",
"arg1_id": "NCT02701777_inc_T25",
"arg2_id": "NCT02701777_inc_T24",
"normalized": []
},
{
"id": "NCT02701777_inc_R10",
"type": "Has_mood",
"arg1_id": "NCT02701777_inc_T27",
"arg2_id": "NCT02701777_inc_T26",
"normalized": []
},
{
"id": "NCT02701777_inc_R11",
"type": "Has_value",
"arg1_id": "NCT02701777_inc_T29",
"arg2_id": "NCT02701777_inc_T30",
"normalized": []
}
] |
NCT02701881_exc
|
NCT02701881
|
[
{
"id": "NCT02701881_exc_text",
"type": "exclusion",
"text": [
"Acute critical limb ischemia\nSevere critical limb ischemia (Rutherford category 6)\nMajor bleeding history within prior 2 months\nKnown hypersensitivity or contraindication to any of the following medications: heparin, aspirin, clopidogrel or contrast agents\nAge > 85 years\nSevere hepatic dysfunction (> 3 times normal reference values)\nSignificant renal dysfunction (Serum creatinine > 2.0 mg/dl\nSignificant leucopenia, neutropenia, thrombocytopenia, anemia, or known bleeding diathesis\nLVEF <40% or clinically overt congestive heart failure\nPregnant women or women with potential childbearing\nLife expectancy <1 year due to comorbidity\nPrevious bypass surgery or stenting of the superficial femoral artery\nUntreated inflow disease of the ipsilateral pelvic arteries (more than 50%stenosis or or occlusion\nPopliteal artery stenosis >50% at P2 or P3 segment\n"
],
"offsets": [
[
0,
856
]
]
}
] |
[
{
"id": "NCT02701881_exc_T1",
"type": "Temporal",
"text": [
"Acute"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T2",
"type": "Qualifier",
"text": [
"critical"
],
"offsets": [
[
6,
14
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T3",
"type": "Condition",
"text": [
"limb ischemia"
],
"offsets": [
[
15,
28
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T4",
"type": "Qualifier",
"text": [
"Severe"
],
"offsets": [
[
29,
35
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T5",
"type": "Qualifier",
"text": [
"critical"
],
"offsets": [
[
36,
44
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T6",
"type": "Condition",
"text": [
"limb ischemia"
],
"offsets": [
[
45,
58
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T7",
"type": "Measurement",
"text": [
"Rutherford category"
],
"offsets": [
[
60,
79
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T8",
"type": "Value",
"text": [
"6"
],
"offsets": [
[
80,
81
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T9",
"type": "Scope",
"text": [
"Severe critical"
],
"offsets": [
[
29,
44
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T10",
"type": "Condition",
"text": [
"Major bleeding history"
],
"offsets": [
[
83,
105
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T11",
"type": "Temporal",
"text": [
"within prior 2 months"
],
"offsets": [
[
106,
127
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T12",
"type": "Condition",
"text": [
"hypersensitivity"
],
"offsets": [
[
134,
150
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T13",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
154,
170
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T14",
"type": "Drug",
"text": [
"heparin"
],
"offsets": [
[
208,
215
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T15",
"type": "Drug",
"text": [
"aspirin"
],
"offsets": [
[
217,
224
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T16",
"type": "Drug",
"text": [
"clopidogrel"
],
"offsets": [
[
226,
237
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T17",
"type": "Drug",
"text": [
"contrast agents"
],
"offsets": [
[
241,
256
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T18",
"type": "Scope",
"text": [
"heparin, aspirin, clopidogrel or contrast agents"
],
"offsets": [
[
208,
256
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T19",
"type": "Scope",
"text": [
"hypersensitivity or contraindication"
],
"offsets": [
[
134,
170
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T20",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
257,
260
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T21",
"type": "Value",
"text": [
"> 85 years"
],
"offsets": [
[
261,
271
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T22",
"type": "Qualifier",
"text": [
"Severe"
],
"offsets": [
[
272,
278
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T23",
"type": "Condition",
"text": [
"hepatic dysfunction"
],
"offsets": [
[
279,
298
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T25",
"type": "Qualifier",
"text": [
"Significant"
],
"offsets": [
[
335,
346
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T26",
"type": "Condition",
"text": [
"renal dysfunction"
],
"offsets": [
[
347,
364
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T27",
"type": "Measurement",
"text": [
"Serum creatinine"
],
"offsets": [
[
366,
382
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T28",
"type": "Value",
"text": [
"> 2.0 mg/dl"
],
"offsets": [
[
383,
394
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T29",
"type": "Condition",
"text": [
"leucopenia"
],
"offsets": [
[
407,
417
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T30",
"type": "Condition",
"text": [
"neutropenia"
],
"offsets": [
[
419,
430
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T31",
"type": "Condition",
"text": [
"thrombocytopenia"
],
"offsets": [
[
432,
448
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T32",
"type": "Condition",
"text": [
"anemia"
],
"offsets": [
[
450,
456
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T33",
"type": "Condition",
"text": [
"bleeding diathesis"
],
"offsets": [
[
467,
485
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T34",
"type": "Qualifier",
"text": [
"Significant"
],
"offsets": [
[
395,
406
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T35",
"type": "Scope",
"text": [
"leucopenia, neutropenia, thrombocytopenia, anemia, or known bleeding diathesis"
],
"offsets": [
[
407,
485
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T36",
"type": "Measurement",
"text": [
"LVEF"
],
"offsets": [
[
486,
490
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T37",
"type": "Value",
"text": [
"<40%"
],
"offsets": [
[
491,
495
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T38",
"type": "Qualifier",
"text": [
"clinically overt"
],
"offsets": [
[
499,
515
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T39",
"type": "Condition",
"text": [
"congestive heart failure"
],
"offsets": [
[
516,
540
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T40",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
541,
549
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T41",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
559,
564
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T42",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
559,
564
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T43",
"type": "Condition",
"text": [
"potential childbearing"
],
"offsets": [
[
570,
592
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T44",
"type": "Observation",
"text": [
"Life expectancy"
],
"offsets": [
[
593,
608
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T45",
"type": "Value",
"text": [
"<1 year"
],
"offsets": [
[
609,
616
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T46",
"type": "Condition",
"text": [
"comorbidity"
],
"offsets": [
[
624,
635
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T47",
"type": "Procedure",
"text": [
"bypass surgery"
],
"offsets": [
[
645,
659
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T48",
"type": "Temporal",
"text": [
"Previous"
],
"offsets": [
[
636,
644
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T49",
"type": "Device",
"text": [
"stenting of the superficial femoral artery"
],
"offsets": [
[
663,
705
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T50",
"type": "Qualifier",
"text": [
"Untreated"
],
"offsets": [
[
706,
715
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T51",
"type": "Condition",
"text": [
"inflow disease"
],
"offsets": [
[
716,
730
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T52",
"type": "Qualifier",
"text": [
"ipsilateral pelvic arteries"
],
"offsets": [
[
738,
765
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T53",
"type": "Value",
"text": [
"more than 50%"
],
"offsets": [
[
767,
780
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T54",
"type": "Condition",
"text": [
"stenosis"
],
"offsets": [
[
780,
788
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T55",
"type": "Value",
"text": [
"occlusion"
],
"offsets": [
[
795,
804
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T56",
"type": "Scope",
"text": [
"%stenosis or",
"\nPopliteal "
],
"offsets": [
[
779,
791
],
[
804,
815
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T57",
"type": "Condition",
"text": [
"Popliteal artery stenosis"
],
"offsets": [
[
805,
830
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T58",
"type": "Value",
"text": [
">50%"
],
"offsets": [
[
831,
835
]
],
"normalized": []
},
{
"id": "NCT02701881_exc_T59",
"type": "Qualifier",
"text": [
"P2 or P3 segment"
],
"offsets": [
[
839,
855
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02701881_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02701881_exc_T3",
"arg2_id": "NCT02701881_exc_T2",
"normalized": []
},
{
"id": "NCT02701881_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02701881_exc_T3",
"arg2_id": "NCT02701881_exc_T1",
"normalized": []
},
{
"id": "NCT02701881_exc_R3",
"type": "Has_value",
"arg1_id": "NCT02701881_exc_T7",
"arg2_id": "NCT02701881_exc_T8",
"normalized": []
},
{
"id": "NCT02701881_exc_R4",
"type": "Has_scope",
"arg1_id": "NCT02701881_exc_T6",
"arg2_id": "NCT02701881_exc_T9",
"normalized": []
},
{
"id": "NCT02701881_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT02701881_exc_T9",
"arg2_id": "NCT02701881_exc_T7",
"normalized": []
},
{
"id": "NCT02701881_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02701881_exc_T10",
"arg2_id": "NCT02701881_exc_T11",
"normalized": []
},
{
"id": "NCT02701881_exc_R7",
"type": "Subsumes",
"arg1_id": "NCT02701881_exc_T19",
"arg2_id": "NCT02701881_exc_T18",
"normalized": []
},
{
"id": "NCT02701881_exc_R8",
"type": "Has_value",
"arg1_id": "NCT02701881_exc_T20",
"arg2_id": "NCT02701881_exc_T21",
"normalized": []
},
{
"id": "NCT02701881_exc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT02701881_exc_T23",
"arg2_id": "NCT02701881_exc_T22",
"normalized": []
},
{
"id": "NCT02701881_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT02701881_exc_T26",
"arg2_id": "NCT02701881_exc_T25",
"normalized": []
},
{
"id": "NCT02701881_exc_R11",
"type": "Has_value",
"arg1_id": "NCT02701881_exc_T27",
"arg2_id": "NCT02701881_exc_T28",
"normalized": []
},
{
"id": "NCT02701881_exc_R12",
"type": "Subsumes",
"arg1_id": "NCT02701881_exc_T25",
"arg2_id": "NCT02701881_exc_T27",
"normalized": []
},
{
"id": "NCT02701881_exc_R13",
"type": "Has_qualifier",
"arg1_id": "NCT02701881_exc_T35",
"arg2_id": "NCT02701881_exc_T34",
"normalized": []
},
{
"id": "NCT02701881_exc_R14",
"type": "Has_value",
"arg1_id": "NCT02701881_exc_T36",
"arg2_id": "NCT02701881_exc_T37",
"normalized": []
},
{
"id": "NCT02701881_exc_R15",
"type": "Has_qualifier",
"arg1_id": "NCT02701881_exc_T39",
"arg2_id": "NCT02701881_exc_T38",
"normalized": []
},
{
"id": "NCT02701881_exc_R16",
"type": "Has_value",
"arg1_id": "NCT02701881_exc_T44",
"arg2_id": "NCT02701881_exc_T45",
"normalized": []
},
{
"id": "NCT02701881_exc_R17",
"type": "AND",
"arg1_id": "NCT02701881_exc_T44",
"arg2_id": "NCT02701881_exc_T46",
"normalized": []
},
{
"id": "NCT02701881_exc_R18",
"type": "Has_temporal",
"arg1_id": "NCT02701881_exc_T47",
"arg2_id": "NCT02701881_exc_T48",
"normalized": []
},
{
"id": "NCT02701881_exc_R19",
"type": "Has_temporal",
"arg1_id": "NCT02701881_exc_T49",
"arg2_id": "NCT02701881_exc_T48",
"normalized": []
},
{
"id": "NCT02701881_exc_R20",
"type": "Has_qualifier",
"arg1_id": "NCT02701881_exc_T51",
"arg2_id": "NCT02701881_exc_T50",
"normalized": []
},
{
"id": "NCT02701881_exc_R21",
"type": "Has_qualifier",
"arg1_id": "NCT02701881_exc_T51",
"arg2_id": "NCT02701881_exc_T52",
"normalized": []
},
{
"id": "NCT02701881_exc_R22",
"type": "Has_scope",
"arg1_id": "NCT02701881_exc_T54",
"arg2_id": "NCT02701881_exc_T56",
"normalized": []
},
{
"id": "NCT02701881_exc_R23",
"type": "AND",
"arg1_id": "NCT02701881_exc_T51",
"arg2_id": "NCT02701881_exc_T54",
"normalized": []
},
{
"id": "NCT02701881_exc_R24",
"type": "Has_value",
"arg1_id": "NCT02701881_exc_T57",
"arg2_id": "NCT02701881_exc_T58",
"normalized": []
},
{
"id": "NCT02701881_exc_R25",
"type": "Has_qualifier",
"arg1_id": "NCT02701881_exc_T57",
"arg2_id": "NCT02701881_exc_T59",
"normalized": []
}
] |
NCT02701881_inc
|
NCT02701881
|
[
{
"id": "NCT02701881_inc_text",
"type": "inclusion",
"text": [
"Age 19 years of older\nModerate or severe claudication (Rutherford category 2 or 3)\nCritical limb ischemia (Rutherford category 4 or 5)\nPatients with signed informed consent\nTarget lesion length =150 mm by angiographic estimation\nStenosis of more than 50% in femoropopliteal artery\nAt least one patent (less than 50 percent stenosed) tibioperoneal runoff vessel.\n"
],
"offsets": [
[
0,
362
]
]
}
] |
[
{
"id": "NCT02701881_inc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T2",
"type": "Value",
"text": [
"19 years of older"
],
"offsets": [
[
4,
21
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T3",
"type": "Qualifier",
"text": [
"Moderate"
],
"offsets": [
[
22,
30
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T4",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
34,
40
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T5",
"type": "Condition",
"text": [
"claudication"
],
"offsets": [
[
41,
53
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T6",
"type": "Measurement",
"text": [
"Rutherford category"
],
"offsets": [
[
55,
74
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T7",
"type": "Value",
"text": [
"2 or 3"
],
"offsets": [
[
75,
81
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T8",
"type": "Scope",
"text": [
"Moderate or severe"
],
"offsets": [
[
22,
40
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T9",
"type": "Qualifier",
"text": [
"Critical"
],
"offsets": [
[
83,
91
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T10",
"type": "Condition",
"text": [
"limb ischemia"
],
"offsets": [
[
92,
105
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T11",
"type": "Measurement",
"text": [
"Rutherford category"
],
"offsets": [
[
107,
126
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T12",
"type": "Value",
"text": [
"4 or 5"
],
"offsets": [
[
127,
133
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T14",
"type": "Condition",
"text": [
"Target lesion"
],
"offsets": [
[
173,
186
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T15",
"type": "Measurement",
"text": [
"length"
],
"offsets": [
[
187,
193
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T16",
"type": "Value",
"text": [
"=150 mm"
],
"offsets": [
[
194,
201
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T17",
"type": "Procedure",
"text": [
"angiographic"
],
"offsets": [
[
205,
217
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T18",
"type": "Condition",
"text": [
"Stenosis"
],
"offsets": [
[
229,
237
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T19",
"type": "Value",
"text": [
"more than 50%"
],
"offsets": [
[
241,
254
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T20",
"type": "Qualifier",
"text": [
"femoropopliteal artery"
],
"offsets": [
[
258,
280
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T21",
"type": "Multiplier",
"text": [
"At least one"
],
"offsets": [
[
281,
293
]
],
"normalized": []
},
{
"id": "NCT02701881_inc_T22",
"type": "Condition",
"text": [
" (les",
"eroneal runoff vessel."
],
"offsets": [
[
300,
305
],
[
339,
361
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02701881_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02701881_inc_T1",
"arg2_id": "NCT02701881_inc_T2",
"normalized": []
},
{
"id": "NCT02701881_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02701881_inc_T6",
"arg2_id": "NCT02701881_inc_T7",
"normalized": []
},
{
"id": "NCT02701881_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT02701881_inc_T8",
"arg2_id": "NCT02701881_inc_T6",
"normalized": []
},
{
"id": "NCT02701881_inc_R4",
"type": "Has_scope",
"arg1_id": "NCT02701881_inc_T5",
"arg2_id": "NCT02701881_inc_T8",
"normalized": []
},
{
"id": "NCT02701881_inc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02701881_inc_T10",
"arg2_id": "NCT02701881_inc_T9",
"normalized": []
},
{
"id": "NCT02701881_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02701881_inc_T11",
"arg2_id": "NCT02701881_inc_T12",
"normalized": []
},
{
"id": "NCT02701881_inc_R7",
"type": "Subsumes",
"arg1_id": "NCT02701881_inc_T9",
"arg2_id": "NCT02701881_inc_T11",
"normalized": []
},
{
"id": "NCT02701881_inc_R8",
"type": "Has_value",
"arg1_id": "NCT02701881_inc_T15",
"arg2_id": "NCT02701881_inc_T16",
"normalized": []
},
{
"id": "NCT02701881_inc_R9",
"type": "AND",
"arg1_id": "NCT02701881_inc_T16",
"arg2_id": "NCT02701881_inc_T17",
"normalized": []
},
{
"id": "NCT02701881_inc_R10",
"type": "AND",
"arg1_id": "NCT02701881_inc_T14",
"arg2_id": "NCT02701881_inc_T15",
"normalized": []
},
{
"id": "NCT02701881_inc_R11",
"type": "Has_value",
"arg1_id": "NCT02701881_inc_T18",
"arg2_id": "NCT02701881_inc_T19",
"normalized": []
},
{
"id": "NCT02701881_inc_R12",
"type": "Has_qualifier",
"arg1_id": "NCT02701881_inc_T18",
"arg2_id": "NCT02701881_inc_T20",
"normalized": []
},
{
"id": "NCT02701881_inc_R13",
"type": "Has_multiplier",
"arg1_id": "NCT02701881_inc_T22",
"arg2_id": "NCT02701881_inc_T21",
"normalized": []
}
] |
NCT02704234_exc
|
NCT02704234
|
[
{
"id": "NCT02704234_exc_text",
"type": "exclusion",
"text": [
"pregnancy \nmenopause \ninterstitial cystitis \nirritable bowel syndrome \nuntreated vaginitis \ncervicitis \npelvic inflammatory disease \nany other pelvic pathology causing pain \nconcomitant physical therapy \nconcomitant biofeedback \nconcomitant massage \nadditional acupuncture \n \n"
],
"offsets": [
[
0,
285
]
]
}
] |
[
{
"id": "NCT02704234_exc_T1",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T2",
"type": "Condition",
"text": [
"menopause"
],
"offsets": [
[
11,
20
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T3",
"type": "Condition",
"text": [
"interstitial cystitis"
],
"offsets": [
[
22,
43
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T4",
"type": "Condition",
"text": [
"irritable bowel syndrome"
],
"offsets": [
[
45,
69
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T5",
"type": "Condition",
"text": [
"untreated vaginitis"
],
"offsets": [
[
71,
90
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T6",
"type": "Condition",
"text": [
"cervicitis"
],
"offsets": [
[
92,
102
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T7",
"type": "Condition",
"text": [
"pelvic inflammatory disease"
],
"offsets": [
[
104,
131
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T8",
"type": "Condition",
"text": [
"pelvic pathology"
],
"offsets": [
[
143,
159
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T9",
"type": "Qualifier",
"text": [
"causing pain"
],
"offsets": [
[
160,
172
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T11",
"type": "Procedure",
"text": [
"physical therapy"
],
"offsets": [
[
186,
202
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T12",
"type": "Temporal",
"text": [
"concomitant"
],
"offsets": [
[
174,
185
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T13",
"type": "Temporal",
"text": [
"concomitant"
],
"offsets": [
[
204,
215
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T14",
"type": "Procedure",
"text": [
"biofeedback"
],
"offsets": [
[
216,
227
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T15",
"type": "Procedure",
"text": [
"massage"
],
"offsets": [
[
241,
248
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T16",
"type": "Temporal",
"text": [
"concomitant"
],
"offsets": [
[
229,
240
]
],
"normalized": []
},
{
"id": "NCT02704234_exc_T17",
"type": "Procedure",
"text": [
"acupuncture"
],
"offsets": [
[
261,
272
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02704234_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02704234_exc_T8",
"arg2_id": "NCT02704234_exc_T9",
"normalized": []
},
{
"id": "NCT02704234_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02704234_exc_T11",
"arg2_id": "NCT02704234_exc_T12",
"normalized": []
},
{
"id": "NCT02704234_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02704234_exc_T14",
"arg2_id": "NCT02704234_exc_T13",
"normalized": []
},
{
"id": "NCT02704234_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02704234_exc_T15",
"arg2_id": "NCT02704234_exc_T16",
"normalized": []
}
] |
NCT02704234_inc
|
NCT02704234
|
[
{
"id": "NCT02704234_inc_text",
"type": "inclusion",
"text": [
"women previously diagnosed with generalized vulvodynia \nwomen previously diagnosed with localized vestibulodynia, \n"
],
"offsets": [
[
0,
115
]
]
}
] |
[
{
"id": "NCT02704234_inc_T1",
"type": "Condition",
"text": [
"generalized vulvodynia"
],
"offsets": [
[
32,
54
]
],
"normalized": []
},
{
"id": "NCT02704234_inc_T2",
"type": "Condition",
"text": [
"localized vestibulodynia"
],
"offsets": [
[
88,
112
]
],
"normalized": []
},
{
"id": "NCT02704234_inc_T3",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02704234_inc_T4",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
56,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
NCT02704754_exc
|
NCT02704754
|
[
{
"id": "NCT02704754_exc_text",
"type": "exclusion",
"text": [
"Psychiatric disorders other than insomnia, PTSD and specific phobias; including bipolar and psychotic disorders and meeting criteria for DSM-5 moderate alcohol or drug use disorders within the past year.\nDiagnosis of a sleep disorder other than insomnia including PSG findings of apnea/hypopnea or periodic limb movement indices > 10/hour;\nMedical conditions that require consistent use of medication or compromise sleep;\nHistory of moderate to severe traumatic brain injury or mild traumatic brain injury with ongoing post-concussive symptoms;\nSuicidal ideation with intent to act or with specific plan and intent in the past 6 months (Type 4 - 5 ideation on the Columbia Suicide Severity Rating Scale) or a concerning history of prior suicidal behavior.\nCaffeine use exceeding 5 cups of coffee per day or its equivalent;\nHabitual bedtimes after 3 AM, habitual rise times after 10 AM, or habitual napping > 1hour/day;\nPregnancy or breastfeeding, or expecting to conceive while in study;\nPositive urine toxicology.\n"
],
"offsets": [
[
0,
1015
]
]
}
] |
[
{
"id": "NCT02704754_exc_T1",
"type": "Condition",
"text": [
"Psychiatric disorders"
],
"offsets": [
[
0,
21
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T2",
"type": "Negation",
"text": [
"other"
],
"offsets": [
[
22,
27
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T3",
"type": "Condition",
"text": [
"insomnia"
],
"offsets": [
[
33,
41
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T4",
"type": "Condition",
"text": [
"PTSD"
],
"offsets": [
[
43,
47
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T5",
"type": "Condition",
"text": [
"phobias"
],
"offsets": [
[
61,
68
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T6",
"type": "Condition",
"text": [
"bipolar"
],
"offsets": [
[
80,
87
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T7",
"type": "Condition",
"text": [
"psychotic disorders"
],
"offsets": [
[
92,
111
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T8",
"type": "Temporal",
"text": [
"past year"
],
"offsets": [
[
193,
202
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T9",
"type": "Qualifier",
"text": [
"DSM-5"
],
"offsets": [
[
137,
142
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T10",
"type": "Qualifier",
"text": [
"moderate"
],
"offsets": [
[
143,
151
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T11",
"type": "Condition",
"text": [
"drug use disorders"
],
"offsets": [
[
163,
181
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T12",
"type": "Condition",
"text": [
"alcohol",
"use disorders"
],
"offsets": [
[
152,
159
],
[
168,
181
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T13",
"type": "Scope",
"text": [
"bipolar and psychotic disorders"
],
"offsets": [
[
80,
111
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T14",
"type": "Scope",
"text": [
"insomnia, PTSD and specific phobias"
],
"offsets": [
[
33,
68
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T15",
"type": "Scope",
"text": [
"alcohol or drug use disorders"
],
"offsets": [
[
152,
181
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T16",
"type": "Condition",
"text": [
"sleep disorder"
],
"offsets": [
[
219,
233
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T17",
"type": "Negation",
"text": [
"other"
],
"offsets": [
[
234,
239
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T18",
"type": "Condition",
"text": [
"insomnia"
],
"offsets": [
[
245,
253
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T19",
"type": "Condition",
"text": [
"apnea"
],
"offsets": [
[
280,
285
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T20",
"type": "Condition",
"text": [
"hypopnea"
],
"offsets": [
[
286,
294
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T21",
"type": "Measurement",
"text": [
"periodic limb movement indices"
],
"offsets": [
[
298,
328
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T22",
"type": "Value",
"text": [
"> 10/hour"
],
"offsets": [
[
329,
338
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T23",
"type": "Measurement",
"text": [
"PSG"
],
"offsets": [
[
264,
267
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T24",
"type": "Scope",
"text": [
"apnea/hypopnea"
],
"offsets": [
[
280,
294
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T25",
"type": "Scope",
"text": [
"PSG findings of apnea/hypopnea or periodic limb movement indices > 10/hour"
],
"offsets": [
[
264,
338
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T27",
"type": "Condition",
"text": [
"traumatic brain injury"
],
"offsets": [
[
452,
474
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T28",
"type": "Qualifier",
"text": [
"moderate"
],
"offsets": [
[
433,
441
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T29",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
445,
451
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T30",
"type": "Condition",
"text": [
"traumatic brain injury"
],
"offsets": [
[
483,
505
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T31",
"type": "Qualifier",
"text": [
"mild"
],
"offsets": [
[
478,
482
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T32",
"type": "Condition",
"text": [
"post-concussive symptoms"
],
"offsets": [
[
519,
543
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T33",
"type": "Scope",
"text": [
"moderate to severe"
],
"offsets": [
[
433,
451
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T34",
"type": "Condition",
"text": [
"Suicidal ideation"
],
"offsets": [
[
545,
562
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T35",
"type": "Temporal",
"text": [
"past 6 months"
],
"offsets": [
[
622,
635
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T36",
"type": "Measurement",
"text": [
"Columbia Suicide Severity Rating Scale"
],
"offsets": [
[
664,
702
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T37",
"type": "Value",
"text": [
" 4 ",
"eation on"
],
"offsets": [
[
641,
644
],
[
650,
659
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T38",
"type": "Value",
"text": [
" 4 - ",
"tion on"
],
"offsets": [
[
641,
646
],
[
652,
659
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T39",
"type": "Scope",
"text": [
"Type 4 - 5 ideation"
],
"offsets": [
[
637,
656
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T40",
"type": "Condition",
"text": [
"suicidal behavior."
],
"offsets": [
[
737,
755
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T41",
"type": "Drug",
"text": [
"Caffeine"
],
"offsets": [
[
756,
764
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T45",
"type": "Measurement",
"text": [
"urine toxicology"
],
"offsets": [
[
997,
1013
]
],
"normalized": []
},
{
"id": "NCT02704754_exc_T46",
"type": "Value",
"text": [
"Positive"
],
"offsets": [
[
988,
996
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02704754_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT02704754_exc_T1",
"arg2_id": "NCT02704754_exc_T13",
"normalized": []
},
{
"id": "NCT02704754_exc_R2",
"type": "Has_negation",
"arg1_id": "NCT02704754_exc_T14",
"arg2_id": "NCT02704754_exc_T2",
"normalized": []
},
{
"id": "NCT02704754_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02704754_exc_T15",
"arg2_id": "NCT02704754_exc_T10",
"normalized": []
},
{
"id": "NCT02704754_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02704754_exc_T15",
"arg2_id": "NCT02704754_exc_T9",
"normalized": []
},
{
"id": "NCT02704754_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02704754_exc_T15",
"arg2_id": "NCT02704754_exc_T8",
"normalized": []
},
{
"id": "NCT02704754_exc_R6",
"type": "Has_value",
"arg1_id": "NCT02704754_exc_T21",
"arg2_id": "NCT02704754_exc_T22",
"normalized": []
},
{
"id": "NCT02704754_exc_R7",
"type": "Has_scope",
"arg1_id": "NCT02704754_exc_T23",
"arg2_id": "NCT02704754_exc_T24",
"normalized": []
},
{
"id": "NCT02704754_exc_R8",
"type": "Subsumes",
"arg1_id": "NCT02704754_exc_T16",
"arg2_id": "NCT02704754_exc_T25",
"normalized": []
},
{
"id": "NCT02704754_exc_R9",
"type": "Has_negation",
"arg1_id": "NCT02704754_exc_T18",
"arg2_id": "NCT02704754_exc_T17",
"normalized": []
},
{
"id": "NCT02704754_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT02704754_exc_T30",
"arg2_id": "NCT02704754_exc_T31",
"normalized": []
},
{
"id": "NCT02704754_exc_R11",
"type": "AND",
"arg1_id": "NCT02704754_exc_T30",
"arg2_id": "NCT02704754_exc_T32",
"normalized": []
},
{
"id": "NCT02704754_exc_R12",
"type": "Has_scope",
"arg1_id": "NCT02704754_exc_T27",
"arg2_id": "NCT02704754_exc_T33",
"normalized": []
},
{
"id": "NCT02704754_exc_R13",
"type": "Has_temporal",
"arg1_id": "NCT02704754_exc_T34",
"arg2_id": "NCT02704754_exc_T35",
"normalized": []
},
{
"id": "NCT02704754_exc_R14",
"type": "Has_scope",
"arg1_id": "NCT02704754_exc_T36",
"arg2_id": "NCT02704754_exc_T39",
"normalized": []
},
{
"id": "NCT02704754_exc_R15",
"type": "Has_value",
"arg1_id": "NCT02704754_exc_T45",
"arg2_id": "NCT02704754_exc_T46",
"normalized": []
}
] |
NCT02704754_inc
|
NCT02704754
|
[
{
"id": "NCT02704754_inc_text",
"type": "inclusion",
"text": [
"Physically healthy adults age 18-55 who meet DSM-5 criteria for insomnia and Criterion A (exposure to a traumatic event) for PTSD. The index trauma must have occurred within the past 5 years and at least 3 months before enrolling, and insomnia symptoms must have started or worsened after the exposure to the index trauma\n"
],
"offsets": [
[
0,
322
]
]
}
] |
[
{
"id": "NCT02704754_inc_T1",
"type": "Qualifier",
"text": [
"healthy"
],
"offsets": [
[
11,
18
]
],
"normalized": []
},
{
"id": "NCT02704754_inc_T2",
"type": "Person",
"text": [
"adults"
],
"offsets": [
[
19,
25
]
],
"normalized": []
},
{
"id": "NCT02704754_inc_T3",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
26,
29
]
],
"normalized": []
},
{
"id": "NCT02704754_inc_T4",
"type": "Value",
"text": [
"18-55"
],
"offsets": [
[
30,
35
]
],
"normalized": []
},
{
"id": "NCT02704754_inc_T5",
"type": "Condition",
"text": [
"insomnia"
],
"offsets": [
[
64,
72
]
],
"normalized": []
},
{
"id": "NCT02704754_inc_T6",
"type": "Qualifier",
"text": [
"DSM-5"
],
"offsets": [
[
45,
50
]
],
"normalized": []
},
{
"id": "NCT02704754_inc_T7",
"type": "Condition",
"text": [
"PTSD"
],
"offsets": [
[
125,
129
]
],
"normalized": []
},
{
"id": "NCT02704754_inc_T8",
"type": "Qualifier",
"text": [
"Criterion A"
],
"offsets": [
[
77,
88
]
],
"normalized": []
},
{
"id": "NCT02704754_inc_T9",
"type": "Condition",
"text": [
"trauma"
],
"offsets": [
[
141,
147
]
],
"normalized": []
},
{
"id": "NCT02704754_inc_T10",
"type": "Qualifier",
"text": [
"index"
],
"offsets": [
[
135,
140
]
],
"normalized": []
},
{
"id": "NCT02704754_inc_T11",
"type": "Temporal",
"text": [
"the past 5 years and at least 3 months"
],
"offsets": [
[
174,
212
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02704754_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02704754_inc_T2",
"arg2_id": "NCT02704754_inc_T1",
"normalized": []
},
{
"id": "NCT02704754_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02704754_inc_T3",
"arg2_id": "NCT02704754_inc_T4",
"normalized": []
},
{
"id": "NCT02704754_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02704754_inc_T5",
"arg2_id": "NCT02704754_inc_T6",
"normalized": []
},
{
"id": "NCT02704754_inc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02704754_inc_T7",
"arg2_id": "NCT02704754_inc_T8",
"normalized": []
},
{
"id": "NCT02704754_inc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02704754_inc_T9",
"arg2_id": "NCT02704754_inc_T10",
"normalized": []
},
{
"id": "NCT02704754_inc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02704754_inc_T9",
"arg2_id": "NCT02704754_inc_T11",
"normalized": []
}
] |
NCT02705222_exc
|
NCT02705222
|
[
{
"id": "NCT02705222_exc_text",
"type": "exclusion",
"text": [
"Age < 45 or > 55 years.\nBlood disorders or coagulopathy.\nDiagnosed or suspected local gynecologic lesion (polyp, adenomyosis, myoma, malignancy or cervical pathology).\nUse intrauterine contraceptive device.\nPregnancy related conditions.\n"
],
"offsets": [
[
0,
237
]
]
}
] |
[
{
"id": "NCT02705222_exc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T2",
"type": "Value",
"text": [
"< 45 or > 55 years"
],
"offsets": [
[
4,
22
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T3",
"type": "Condition",
"text": [
"Blood disorders"
],
"offsets": [
[
24,
39
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T4",
"type": "Condition",
"text": [
"coagulopathy"
],
"offsets": [
[
43,
55
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T5",
"type": "Condition",
"text": [
"local gynecologic lesion"
],
"offsets": [
[
80,
104
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T6",
"type": "Mood",
"text": [
"Diagnosed"
],
"offsets": [
[
57,
66
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T7",
"type": "Mood",
"text": [
"suspected"
],
"offsets": [
[
70,
79
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T8",
"type": "Scope",
"text": [
"Diagnosed or suspected"
],
"offsets": [
[
57,
79
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T9",
"type": "Condition",
"text": [
"polyp"
],
"offsets": [
[
106,
111
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T10",
"type": "Condition",
"text": [
"adenomyosis"
],
"offsets": [
[
113,
124
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T11",
"type": "Condition",
"text": [
"myoma"
],
"offsets": [
[
126,
131
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T12",
"type": "Condition",
"text": [
"malignancy"
],
"offsets": [
[
133,
143
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T13",
"type": "Condition",
"text": [
"cervical pathology"
],
"offsets": [
[
147,
165
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T14",
"type": "Scope",
"text": [
"polyp, adenomyosis, myoma, malignancy or cervical pathology"
],
"offsets": [
[
106,
165
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T15",
"type": "Device",
"text": [
"intrauterine contraceptive device"
],
"offsets": [
[
172,
205
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T16",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
207,
216
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T17",
"type": "Condition",
"text": [
"conditions"
],
"offsets": [
[
225,
235
]
],
"normalized": []
},
{
"id": "NCT02705222_exc_T18",
"type": "Qualifier",
"text": [
"Pregnancy related"
],
"offsets": [
[
207,
224
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02705222_exc_R1",
"type": "Has_value",
"arg1_id": "NCT02705222_exc_T1",
"arg2_id": "NCT02705222_exc_T2",
"normalized": []
},
{
"id": "NCT02705222_exc_R2",
"type": "Has_scope",
"arg1_id": "NCT02705222_exc_T5",
"arg2_id": "NCT02705222_exc_T8",
"normalized": []
},
{
"id": "NCT02705222_exc_R3",
"type": "Subsumes",
"arg1_id": "NCT02705222_exc_T5",
"arg2_id": "NCT02705222_exc_T14",
"normalized": []
},
{
"id": "NCT02705222_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02705222_exc_T17",
"arg2_id": "NCT02705222_exc_T18",
"normalized": []
}
] |
NCT02705222_inc
|
NCT02705222
|
[
{
"id": "NCT02705222_inc_text",
"type": "inclusion",
"text": [
"Perimenopausal women complaining of abnormal uterine bleeding (menorrhagia, metrorrhagia, polymenorrhoea or polymenorrhagia) without local gynecological cause.\nFailure of medical treatment for at least 3 months.\n"
],
"offsets": [
[
0,
212
]
]
}
] |
[
{
"id": "NCT02705222_inc_T1",
"type": "Person",
"text": [
"Perimenopausal"
],
"offsets": [
[
0,
14
]
],
"normalized": []
},
{
"id": "NCT02705222_inc_T2",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
15,
20
]
],
"normalized": []
},
{
"id": "NCT02705222_inc_T3",
"type": "Condition",
"text": [
"abnormal uterine bleeding"
],
"offsets": [
[
36,
61
]
],
"normalized": []
},
{
"id": "NCT02705222_inc_T4",
"type": "Condition",
"text": [
"menorrhagia"
],
"offsets": [
[
63,
74
]
],
"normalized": []
},
{
"id": "NCT02705222_inc_T5",
"type": "Condition",
"text": [
"metrorrhagia"
],
"offsets": [
[
76,
88
]
],
"normalized": []
},
{
"id": "NCT02705222_inc_T6",
"type": "Condition",
"text": [
"polymenorrhoea"
],
"offsets": [
[
90,
104
]
],
"normalized": []
},
{
"id": "NCT02705222_inc_T7",
"type": "Condition",
"text": [
"polymenorrhagia"
],
"offsets": [
[
108,
123
]
],
"normalized": []
},
{
"id": "NCT02705222_inc_T8",
"type": "Scope",
"text": [
"menorrhagia, metrorrhagia, polymenorrhoea or polymenorrhagia"
],
"offsets": [
[
63,
123
]
],
"normalized": []
},
{
"id": "NCT02705222_inc_T9",
"type": "Negation",
"text": [
"without"
],
"offsets": [
[
125,
132
]
],
"normalized": []
},
{
"id": "NCT02705222_inc_T10",
"type": "Condition",
"text": [
"local gynecological cause"
],
"offsets": [
[
133,
158
]
],
"normalized": []
},
{
"id": "NCT02705222_inc_T11",
"type": "Procedure",
"text": [
"medical treatment"
],
"offsets": [
[
171,
188
]
],
"normalized": []
},
{
"id": "NCT02705222_inc_T12",
"type": "Observation",
"text": [
"Failure"
],
"offsets": [
[
160,
167
]
],
"normalized": []
},
{
"id": "NCT02705222_inc_T13",
"type": "Multiplier",
"text": [
"for at least 3 months"
],
"offsets": [
[
189,
210
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02705222_inc_R1",
"type": "Has_negation",
"arg1_id": "NCT02705222_inc_T10",
"arg2_id": "NCT02705222_inc_T9",
"normalized": []
},
{
"id": "NCT02705222_inc_R2",
"type": "Subsumes",
"arg1_id": "NCT02705222_inc_T3",
"arg2_id": "NCT02705222_inc_T8",
"normalized": []
},
{
"id": "NCT02705222_inc_R3",
"type": "AND",
"arg1_id": "NCT02705222_inc_T3",
"arg2_id": "NCT02705222_inc_T10",
"normalized": []
},
{
"id": "NCT02705222_inc_R5",
"type": "Has_multiplier",
"arg1_id": "NCT02705222_inc_T12",
"arg2_id": "NCT02705222_inc_T13",
"normalized": []
}
] |
NCT02707809_exc
|
NCT02707809
|
[
{
"id": "NCT02707809_exc_text",
"type": "exclusion",
"text": [
"allergic history to dexmedetomidine\nrefractory bradycardia < 60 bpm despite treatment\nsevere atrioventricular block (2nd and 3rd degree)\nprevious operation of tongue\n"
],
"offsets": [
[
0,
166
]
]
}
] |
[
{
"id": "NCT02707809_exc_T1",
"type": "Condition",
"text": [
"allergic"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "NCT02707809_exc_T2",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
9,
16
]
],
"normalized": []
},
{
"id": "NCT02707809_exc_T3",
"type": "Drug",
"text": [
"dexmedetomidine"
],
"offsets": [
[
20,
35
]
],
"normalized": []
},
{
"id": "NCT02707809_exc_T4",
"type": "Qualifier",
"text": [
"refractory"
],
"offsets": [
[
36,
46
]
],
"normalized": []
},
{
"id": "NCT02707809_exc_T5",
"type": "Condition",
"text": [
"bradycardia"
],
"offsets": [
[
47,
58
]
],
"normalized": []
},
{
"id": "NCT02707809_exc_T6",
"type": "Value",
"text": [
"< 60 bpm"
],
"offsets": [
[
59,
67
]
],
"normalized": []
},
{
"id": "NCT02707809_exc_T7",
"type": "Qualifier",
"text": [
"despite treatment"
],
"offsets": [
[
68,
85
]
],
"normalized": []
},
{
"id": "NCT02707809_exc_T8",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
76,
85
]
],
"normalized": []
},
{
"id": "NCT02707809_exc_T9",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
86,
92
]
],
"normalized": []
},
{
"id": "NCT02707809_exc_T10",
"type": "Condition",
"text": [
"atrioventricular block"
],
"offsets": [
[
93,
115
]
],
"normalized": []
},
{
"id": "NCT02707809_exc_T11",
"type": "Qualifier",
"text": [
"d a",
"gree)"
],
"offsets": [
[
119,
122
],
[
131,
136
]
],
"normalized": []
},
{
"id": "NCT02707809_exc_T12",
"type": "Qualifier",
"text": [
"3rd degree"
],
"offsets": [
[
125,
135
]
],
"normalized": []
},
{
"id": "NCT02707809_exc_T13",
"type": "Scope",
"text": [
"2nd and 3rd degree"
],
"offsets": [
[
117,
135
]
],
"normalized": []
},
{
"id": "NCT02707809_exc_T14",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
137,
145
]
],
"normalized": []
},
{
"id": "NCT02707809_exc_T15",
"type": "Procedure",
"text": [
"operation of tongue"
],
"offsets": [
[
146,
165
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02707809_exc_R1",
"type": "Has_temporal",
"arg1_id": "NCT02707809_exc_T1",
"arg2_id": "NCT02707809_exc_T2",
"normalized": []
},
{
"id": "NCT02707809_exc_R2",
"type": "AND",
"arg1_id": "NCT02707809_exc_T1",
"arg2_id": "NCT02707809_exc_T3",
"normalized": []
},
{
"id": "NCT02707809_exc_R3",
"type": "Has_value",
"arg1_id": "NCT02707809_exc_T5",
"arg2_id": "NCT02707809_exc_T6",
"normalized": []
},
{
"id": "NCT02707809_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02707809_exc_T5",
"arg2_id": "NCT02707809_exc_T4",
"normalized": []
},
{
"id": "NCT02707809_exc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT02707809_exc_T5",
"arg2_id": "NCT02707809_exc_T7",
"normalized": []
},
{
"id": "NCT02707809_exc_R7",
"type": "Subsumes",
"arg1_id": "NCT02707809_exc_T9",
"arg2_id": "NCT02707809_exc_T13",
"normalized": []
},
{
"id": "NCT02707809_exc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT02707809_exc_T10",
"arg2_id": "NCT02707809_exc_T9",
"normalized": []
},
{
"id": "NCT02707809_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT02707809_exc_T15",
"arg2_id": "NCT02707809_exc_T14",
"normalized": []
}
] |
NCT02707809_inc
|
NCT02707809
|
[
{
"id": "NCT02707809_inc_text",
"type": "inclusion",
"text": [
"kidney transplant recipient\n"
],
"offsets": [
[
0,
28
]
]
}
] |
[
{
"id": "NCT02707809_inc_T1",
"type": "Procedure",
"text": [
"kidney transplant"
],
"offsets": [
[
0,
17
]
],
"normalized": []
}
] |
[] |
[] |
[] |
NCT02707874_exc
|
NCT02707874
|
[
{
"id": "NCT02707874_exc_text",
"type": "exclusion",
"text": [
"Patients who undergo iliac crest bone graft harvesting as part of their surgery\nPreexisting neurological deficits or peripheral neuropathy in the distribution of the sciatic nerve\nLocal infection\nContraindication to regional anesthesia e.g. bleeding diathesis, coagulopathy\nChronic pain disorders\nHistory of use of over 30mg oxycodone or equivalent per day\nAllergy to local anesthetics\nHistory of significant psychiatric conditions that may affect patient assessment\nPregnancy\nInability to provide informed consent\n"
],
"offsets": [
[
0,
515
]
]
}
] |
[
{
"id": "NCT02707874_exc_T1",
"type": "Procedure",
"text": [
"iliac crest bone graft harvesting"
],
"offsets": [
[
21,
54
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T2",
"type": "Condition",
"text": [
"neurological deficits"
],
"offsets": [
[
92,
113
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T3",
"type": "Condition",
"text": [
"peripheral neuropathy"
],
"offsets": [
[
117,
138
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T4",
"type": "Qualifier",
"text": [
"sciatic nerve"
],
"offsets": [
[
166,
179
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T5",
"type": "Scope",
"text": [
"neurological deficits or peripheral neuropathy"
],
"offsets": [
[
92,
138
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T6",
"type": "Condition",
"text": [
"Local infection"
],
"offsets": [
[
180,
195
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T7",
"type": "Condition",
"text": [
"Contraindication"
],
"offsets": [
[
196,
212
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T8",
"type": "Procedure",
"text": [
"regional anesthesia"
],
"offsets": [
[
216,
235
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T9",
"type": "Condition",
"text": [
"bleeding diathesis"
],
"offsets": [
[
241,
259
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T10",
"type": "Condition",
"text": [
"coagulopathy"
],
"offsets": [
[
261,
273
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T11",
"type": "Scope",
"text": [
"bleeding diathesis, coagulopathy"
],
"offsets": [
[
241,
273
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T12",
"type": "Condition",
"text": [
"Chronic pain"
],
"offsets": [
[
274,
286
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T13",
"type": "Multiplier",
"text": [
"30mg oxyc",
"ay\nAlle"
],
"offsets": [
[
320,
329
],
[
354,
361
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T14",
"type": "Drug",
"text": [
"oxycodone"
],
"offsets": [
[
325,
334
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T15",
"type": "Drug",
"text": [
"done or e",
"alent per"
],
"offsets": [
[
330,
339
],
[
343,
352
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T16",
"type": "Scope",
"text": [
"oxycodone or equivalent"
],
"offsets": [
[
325,
348
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T17",
"type": "Procedure",
"text": [
"local anesthetics"
],
"offsets": [
[
368,
385
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T18",
"type": "Condition",
"text": [
"Allergy"
],
"offsets": [
[
357,
364
]
],
"normalized": []
},
{
"id": "NCT02707874_exc_T20",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
467,
476
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02707874_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02707874_exc_T5",
"arg2_id": "NCT02707874_exc_T4",
"normalized": []
},
{
"id": "NCT02707874_exc_R2",
"type": "Subsumes",
"arg1_id": "NCT02707874_exc_T7",
"arg2_id": "NCT02707874_exc_T11",
"normalized": []
},
{
"id": "NCT02707874_exc_R3",
"type": "AND",
"arg1_id": "NCT02707874_exc_T7",
"arg2_id": "NCT02707874_exc_T8",
"normalized": []
},
{
"id": "NCT02707874_exc_R4",
"type": "Has_multiplier",
"arg1_id": "NCT02707874_exc_T16",
"arg2_id": "NCT02707874_exc_T13",
"normalized": []
},
{
"id": "NCT02707874_exc_R5",
"type": "AND",
"arg1_id": "NCT02707874_exc_T18",
"arg2_id": "NCT02707874_exc_T17",
"normalized": []
}
] |
NCT02707874_inc
|
NCT02707874
|
[
{
"id": "NCT02707874_inc_text",
"type": "inclusion",
"text": [
"Inpatients having major foot and ankle surgery that will benefit from continuous popliteal sciatic nerve block with an indwelling catheter\nAmerican Society Anesthesiologists (ASA) physical status I-III\n18-85 years of age, inclusive\n40-120 kg, inclusive\n150 cm of height or greater\n"
],
"offsets": [
[
0,
281
]
]
}
] |
[
{
"id": "NCT02707874_inc_T1",
"type": "Visit",
"text": [
"Inpatients"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "NCT02707874_inc_T2",
"type": "Procedure",
"text": [
"major foot and ankle surgery"
],
"offsets": [
[
18,
46
]
],
"normalized": []
},
{
"id": "NCT02707874_inc_T3",
"type": "Device",
"text": [
"indwelling catheter"
],
"offsets": [
[
119,
138
]
],
"normalized": []
},
{
"id": "NCT02707874_inc_T4",
"type": "Procedure",
"text": [
"popliteal sciatic nerve block"
],
"offsets": [
[
81,
110
]
],
"normalized": []
},
{
"id": "NCT02707874_inc_T5",
"type": "Qualifier",
"text": [
"continuous"
],
"offsets": [
[
70,
80
]
],
"normalized": []
},
{
"id": "NCT02707874_inc_T6",
"type": "Measurement",
"text": [
"merican Society Anesthesiologists",
"hysical status"
],
"offsets": [
[
140,
173
],
[
181,
195
]
],
"normalized": []
},
{
"id": "NCT02707874_inc_T7",
"type": "Measurement",
"text": [
"ASA"
],
"offsets": [
[
175,
178
]
],
"normalized": []
},
{
"id": "NCT02707874_inc_T8",
"type": "Value",
"text": [
"I-III"
],
"offsets": [
[
196,
201
]
],
"normalized": []
},
{
"id": "NCT02707874_inc_T9",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
217,
220
]
],
"normalized": []
},
{
"id": "NCT02707874_inc_T10",
"type": "Value",
"text": [
"18-85 years"
],
"offsets": [
[
202,
213
]
],
"normalized": []
},
{
"id": "NCT02707874_inc_T11",
"type": "Person",
"text": [
"kg"
],
"offsets": [
[
239,
241
]
],
"normalized": []
},
{
"id": "NCT02707874_inc_T12",
"type": "Value",
"text": [
"40-120"
],
"offsets": [
[
232,
238
]
],
"normalized": []
},
{
"id": "NCT02707874_inc_T13",
"type": "Person",
"text": [
"height"
],
"offsets": [
[
263,
269
]
],
"normalized": []
},
{
"id": "NCT02707874_inc_T14",
"type": "Value",
"text": [
"cm of",
"reater"
],
"offsets": [
[
257,
262
],
[
274,
280
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02707874_inc_R1",
"type": "AND",
"arg1_id": "NCT02707874_inc_T2",
"arg2_id": "NCT02707874_inc_T3",
"normalized": []
},
{
"id": "NCT02707874_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02707874_inc_T4",
"arg2_id": "NCT02707874_inc_T5",
"normalized": []
},
{
"id": "NCT02707874_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT02707874_inc_T6",
"arg2_id": "NCT02707874_inc_T7",
"normalized": []
},
{
"id": "NCT02707874_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02707874_inc_T6",
"arg2_id": "NCT02707874_inc_T8",
"normalized": []
},
{
"id": "NCT02707874_inc_R5",
"type": "Has_value",
"arg1_id": "NCT02707874_inc_T9",
"arg2_id": "NCT02707874_inc_T10",
"normalized": []
},
{
"id": "NCT02707874_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02707874_inc_T11",
"arg2_id": "NCT02707874_inc_T12",
"normalized": []
},
{
"id": "NCT02707874_inc_R7",
"type": "Has_value",
"arg1_id": "NCT02707874_inc_T13",
"arg2_id": "NCT02707874_inc_T14",
"normalized": []
}
] |
NCT02713087_exc
|
NCT02713087
|
[
{
"id": "NCT02713087_exc_text",
"type": "exclusion",
"text": [
"Age younger than 18 yrs. or older than 75 yrs.\nPregnancy or nursing (negative pregnancy blood test)\nHistory of allergic reactions to phenylephrine or ephedrine\neGFR < 60ml/min/1.73m2\n"
],
"offsets": [
[
0,
183
]
]
}
] |
[
{
"id": "NCT02713087_exc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02713087_exc_T2",
"type": "Value",
"text": [
"younger than 18 yrs. or older than 75 yrs."
],
"offsets": [
[
4,
46
]
],
"normalized": []
},
{
"id": "NCT02713087_exc_T3",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
47,
56
]
],
"normalized": []
},
{
"id": "NCT02713087_exc_T4",
"type": "Condition",
"text": [
"nursing"
],
"offsets": [
[
60,
67
]
],
"normalized": []
},
{
"id": "NCT02713087_exc_T5",
"type": "Value",
"text": [
"negative"
],
"offsets": [
[
69,
77
]
],
"normalized": []
},
{
"id": "NCT02713087_exc_T6",
"type": "Measurement",
"text": [
"pregnancy blood test"
],
"offsets": [
[
78,
98
]
],
"normalized": []
},
{
"id": "NCT02713087_exc_T7",
"type": "Scope",
"text": [
"Pregnancy or nursing"
],
"offsets": [
[
47,
67
]
],
"normalized": []
},
{
"id": "NCT02713087_exc_T8",
"type": "Scope",
"text": [
"negative pregnancy blood test"
],
"offsets": [
[
69,
98
]
],
"normalized": []
},
{
"id": "NCT02713087_exc_T9",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
100,
107
]
],
"normalized": []
},
{
"id": "NCT02713087_exc_T10",
"type": "Condition",
"text": [
"allergic reactions"
],
"offsets": [
[
111,
129
]
],
"normalized": []
},
{
"id": "NCT02713087_exc_T11",
"type": "Drug",
"text": [
"phenylephrine"
],
"offsets": [
[
133,
146
]
],
"normalized": []
},
{
"id": "NCT02713087_exc_T12",
"type": "Drug",
"text": [
"ephedrine"
],
"offsets": [
[
150,
159
]
],
"normalized": []
},
{
"id": "NCT02713087_exc_T13",
"type": "Scope",
"text": [
"phenylephrine or ephedrine"
],
"offsets": [
[
133,
159
]
],
"normalized": []
},
{
"id": "NCT02713087_exc_T14",
"type": "Measurement",
"text": [
"eGFR"
],
"offsets": [
[
160,
164
]
],
"normalized": []
},
{
"id": "NCT02713087_exc_T15",
"type": "Value",
"text": [
"< 60ml/min/1.73m2"
],
"offsets": [
[
165,
182
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02713087_exc_R1",
"type": "Has_value",
"arg1_id": "NCT02713087_exc_T1",
"arg2_id": "NCT02713087_exc_T2",
"normalized": []
},
{
"id": "NCT02713087_exc_R2",
"type": "Has_value",
"arg1_id": "NCT02713087_exc_T6",
"arg2_id": "NCT02713087_exc_T5",
"normalized": []
},
{
"id": "NCT02713087_exc_R3",
"type": "Subsumes",
"arg1_id": "NCT02713087_exc_T7",
"arg2_id": "NCT02713087_exc_T8",
"normalized": []
},
{
"id": "NCT02713087_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02713087_exc_T10",
"arg2_id": "NCT02713087_exc_T9",
"normalized": []
},
{
"id": "NCT02713087_exc_R5",
"type": "Has_scope",
"arg1_id": "NCT02713087_exc_T10",
"arg2_id": "NCT02713087_exc_T13",
"normalized": []
},
{
"id": "NCT02713087_exc_R6",
"type": "Has_value",
"arg1_id": "NCT02713087_exc_T14",
"arg2_id": "NCT02713087_exc_T15",
"normalized": []
}
] |
NCT02713087_inc
|
NCT02713087
|
[
{
"id": "NCT02713087_inc_text",
"type": "inclusion",
"text": [
"Patients scheduled for supine-positioned elective craniotomy for supratentorial malignant and non-malignant brain tumors 3 cm or larger (measured as the largest diameter in any plane on MR images)\nASA (American Society of Anesthesiologist) status 1-3 (27)\nWritten informed consent from participating patients\n"
],
"offsets": [
[
0,
309
]
]
}
] |
[
{
"id": "NCT02713087_inc_T1",
"type": "Mood",
"text": [
"scheduled"
],
"offsets": [
[
9,
18
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T2",
"type": "Procedure",
"text": [
"supine-positioned elective craniotomy"
],
"offsets": [
[
23,
60
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T3",
"type": "Qualifier",
"text": [
"supratentorial"
],
"offsets": [
[
65,
79
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T4",
"type": "Qualifier",
"text": [
"malignant"
],
"offsets": [
[
80,
89
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T5",
"type": "Negation",
"text": [
"non"
],
"offsets": [
[
94,
97
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T6",
"type": "Qualifier",
"text": [
"malignant"
],
"offsets": [
[
98,
107
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T7",
"type": "Condition",
"text": [
"brain tumors"
],
"offsets": [
[
108,
120
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T8",
"type": "Qualifier",
"text": [
"3 cm or larger"
],
"offsets": [
[
121,
135
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T9",
"type": "Scope",
"text": [
"malignant and non-malignant"
],
"offsets": [
[
80,
107
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T10",
"type": "Qualifier",
"text": [
"largest diameter in any plane"
],
"offsets": [
[
153,
182
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T11",
"type": "Procedure",
"text": [
"MR"
],
"offsets": [
[
186,
188
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T12",
"type": "Scope",
"text": [
"largest diameter in any plane on MR"
],
"offsets": [
[
153,
188
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T13",
"type": "Scope",
"text": [
"supratentorial malignant and non-malignant brain tumors 3 cm or larger (measured as the largest diameter in any plane on MR images)"
],
"offsets": [
[
65,
196
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T14",
"type": "Measurement",
"text": [
"SA",
"tatus"
],
"offsets": [
[
198,
200
],
[
241,
246
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T15",
"type": "Measurement",
"text": [
"merican Society of Anesthesiologist)",
"tatus"
],
"offsets": [
[
203,
239
],
[
241,
246
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T16",
"type": "Scope",
"text": [
"ASA (American Society of Anesthesiologist)"
],
"offsets": [
[
197,
239
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T17",
"type": "Value",
"text": [
"1-3"
],
"offsets": [
[
247,
250
]
],
"normalized": []
},
{
"id": "NCT02713087_inc_T18",
"type": "Value",
"text": [
"27"
],
"offsets": [
[
252,
254
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02713087_inc_R1",
"type": "Has_negation",
"arg1_id": "NCT02713087_inc_T6",
"arg2_id": "NCT02713087_inc_T5",
"normalized": []
},
{
"id": "NCT02713087_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02713087_inc_T7",
"arg2_id": "NCT02713087_inc_T8",
"normalized": []
},
{
"id": "NCT02713087_inc_R3",
"type": "Has_scope",
"arg1_id": "NCT02713087_inc_T7",
"arg2_id": "NCT02713087_inc_T9",
"normalized": []
},
{
"id": "NCT02713087_inc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02713087_inc_T7",
"arg2_id": "NCT02713087_inc_T3",
"normalized": []
},
{
"id": "NCT02713087_inc_R5",
"type": "Has_scope",
"arg1_id": "NCT02713087_inc_T8",
"arg2_id": "NCT02713087_inc_T12",
"normalized": []
},
{
"id": "NCT02713087_inc_R6",
"type": "Has_mood",
"arg1_id": "NCT02713087_inc_T2",
"arg2_id": "NCT02713087_inc_T1",
"normalized": []
},
{
"id": "NCT02713087_inc_R7",
"type": "Has_scope",
"arg1_id": "NCT02713087_inc_T2",
"arg2_id": "NCT02713087_inc_T13",
"normalized": []
},
{
"id": "NCT02713087_inc_R8",
"type": "Subsumes",
"arg1_id": "NCT02713087_inc_T14",
"arg2_id": "NCT02713087_inc_T15",
"normalized": []
},
{
"id": "NCT02713087_inc_R9",
"type": "Subsumes",
"arg1_id": "NCT02713087_inc_T17",
"arg2_id": "NCT02713087_inc_T18",
"normalized": []
},
{
"id": "NCT02713087_inc_R10",
"type": "Has_value",
"arg1_id": "NCT02713087_inc_T14",
"arg2_id": "NCT02713087_inc_T17",
"normalized": []
}
] |
NCT02714725_exc
|
NCT02714725
|
[
{
"id": "NCT02714725_exc_text",
"type": "exclusion",
"text": [
"Patient refusal.\nEmergency surgeries\nRedo surgeries\nPregnancy\nVasculitis\nInflammation or infection at the study site\nHistory of allergic reaction to study medications\n"
],
"offsets": [
[
0,
167
]
]
}
] |
[
{
"id": "NCT02714725_exc_T2",
"type": "Procedure",
"text": [
"Emergency surgeries"
],
"offsets": [
[
17,
36
]
],
"normalized": []
},
{
"id": "NCT02714725_exc_T3",
"type": "Procedure",
"text": [
"Redo surgeries"
],
"offsets": [
[
37,
51
]
],
"normalized": []
},
{
"id": "NCT02714725_exc_T4",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
52,
61
]
],
"normalized": []
},
{
"id": "NCT02714725_exc_T5",
"type": "Condition",
"text": [
"Vasculitis"
],
"offsets": [
[
62,
72
]
],
"normalized": []
},
{
"id": "NCT02714725_exc_T6",
"type": "Condition",
"text": [
"Inflammation"
],
"offsets": [
[
73,
85
]
],
"normalized": []
},
{
"id": "NCT02714725_exc_T7",
"type": "Condition",
"text": [
"infection"
],
"offsets": [
[
89,
98
]
],
"normalized": []
},
{
"id": "NCT02714725_exc_T8",
"type": "Qualifier",
"text": [
"study site"
],
"offsets": [
[
106,
116
]
],
"normalized": []
},
{
"id": "NCT02714725_exc_T9",
"type": "Scope",
"text": [
"Inflammation or infection"
],
"offsets": [
[
73,
98
]
],
"normalized": []
},
{
"id": "NCT02714725_exc_T10",
"type": "Condition",
"text": [
"allergic"
],
"offsets": [
[
128,
136
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02714725_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02714725_exc_T9",
"arg2_id": "NCT02714725_exc_T8",
"normalized": []
}
] |
NCT02714725_inc
|
NCT02714725
|
[
{
"id": "NCT02714725_inc_text",
"type": "inclusion",
"text": [
"Adult patients aged (>18), males and females, undergoing elective coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB).\n"
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "NCT02714725_inc_T1",
"type": "Person",
"text": [
"aged"
],
"offsets": [
[
15,
19
]
],
"normalized": []
},
{
"id": "NCT02714725_inc_T2",
"type": "Value",
"text": [
">18"
],
"offsets": [
[
21,
24
]
],
"normalized": []
},
{
"id": "NCT02714725_inc_T3",
"type": "Person",
"text": [
"males"
],
"offsets": [
[
27,
32
]
],
"normalized": []
},
{
"id": "NCT02714725_inc_T4",
"type": "Person",
"text": [
"females"
],
"offsets": [
[
37,
44
]
],
"normalized": []
},
{
"id": "NCT02714725_inc_T5",
"type": "Qualifier",
"text": [
"elective"
],
"offsets": [
[
57,
65
]
],
"normalized": []
},
{
"id": "NCT02714725_inc_T6",
"type": "Procedure",
"text": [
"surgery",
"coronary artery bypass graft"
],
"offsets": [
[
102,
109
],
[
66,
94
]
],
"normalized": []
},
{
"id": "NCT02714725_inc_T7",
"type": "Procedure",
"text": [
"CABG"
],
"offsets": [
[
96,
100
]
],
"normalized": []
},
{
"id": "NCT02714725_inc_T8",
"type": "Procedure",
"text": [
"cardiopulmonary bypass"
],
"offsets": [
[
115,
137
]
],
"normalized": []
},
{
"id": "NCT02714725_inc_T9",
"type": "Procedure",
"text": [
"CPB"
],
"offsets": [
[
139,
142
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02714725_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02714725_inc_T1",
"arg2_id": "NCT02714725_inc_T2",
"normalized": []
},
{
"id": "NCT02714725_inc_R2",
"type": "Subsumes",
"arg1_id": "NCT02714725_inc_T6",
"arg2_id": "NCT02714725_inc_T7",
"normalized": []
},
{
"id": "NCT02714725_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02714725_inc_T6",
"arg2_id": "NCT02714725_inc_T5",
"normalized": []
},
{
"id": "NCT02714725_inc_R4",
"type": "Subsumes",
"arg1_id": "NCT02714725_inc_T8",
"arg2_id": "NCT02714725_inc_T9",
"normalized": []
},
{
"id": "NCT02714725_inc_R5",
"type": "AND",
"arg1_id": "NCT02714725_inc_T6",
"arg2_id": "NCT02714725_inc_T8",
"normalized": []
}
] |
NCT02715466_exc
|
NCT02715466
|
[
{
"id": "NCT02715466_exc_text",
"type": "exclusion",
"text": [
"Administration of HES, dextrane solutions or > 500 ml of Gelatin solutions within the 24 h prior to randomization\nDeath expected within the next 48 h (moribund patients as defined by ASA = class V)\nPatients whose medical condition does preclude the PLR manoeuvre\nPatients for whom the need of pressure infusions are expected\nRequirement for renal support (either continuous or discontinuous techniques, including intermittent haemodialysis, haemofiltration and haemodiafiltration)\nPatients receiving therapeutic heparin medication due to chronic coagulation disease / anticoagulation medication (i.e. partial thromboplastin time > 60 sec)\nAcutely burned patients\nContraindications according to summary of product characteristics of investigational test and reference product\nSimultaneous participation in another interventional clinical trial (drugs or medical devices studies)\n"
],
"offsets": [
[
0,
878
]
]
}
] |
[
{
"id": "NCT02715466_exc_T1",
"type": "Drug",
"text": [
"HES"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T2",
"type": "Drug",
"text": [
"dextrane solutions"
],
"offsets": [
[
23,
41
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T3",
"type": "Multiplier",
"text": [
"> 500 ml"
],
"offsets": [
[
45,
53
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T4",
"type": "Drug",
"text": [
"Gelatin solutions"
],
"offsets": [
[
57,
74
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T5",
"type": "Temporal",
"text": [
"within the 24 h prior to randomization"
],
"offsets": [
[
75,
113
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T6",
"type": "Scope",
"text": [
"HES, dextrane solutions or > 500 ml of Gelatin solutions"
],
"offsets": [
[
18,
74
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T7",
"type": "Observation",
"text": [
"Death expected"
],
"offsets": [
[
114,
128
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T8",
"type": "Temporal",
"text": [
"within the next 48 h"
],
"offsets": [
[
129,
149
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T9",
"type": "Condition",
"text": [
"moribund"
],
"offsets": [
[
151,
159
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T10",
"type": "Measurement",
"text": [
"ASA"
],
"offsets": [
[
183,
186
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T11",
"type": "Value",
"text": [
"= class V"
],
"offsets": [
[
187,
196
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T14",
"type": "Condition",
"text": [
"renal support"
],
"offsets": [
[
341,
354
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T15",
"type": "Mood",
"text": [
"Requirement for"
],
"offsets": [
[
325,
340
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T16",
"type": "Drug",
"text": [
"heparin"
],
"offsets": [
[
512,
519
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T17",
"type": "Condition",
"text": [
"chronic coagulation disease"
],
"offsets": [
[
538,
565
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T18",
"type": "Drug",
"text": [
"anticoagulation medication"
],
"offsets": [
[
568,
594
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T19",
"type": "Measurement",
"text": [
"partial thromboplastin time"
],
"offsets": [
[
601,
628
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T20",
"type": "Value",
"text": [
"> 60 sec"
],
"offsets": [
[
629,
637
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T21",
"type": "Scope",
"text": [
"chronic coagulation disease / anticoagulation medication"
],
"offsets": [
[
538,
594
]
],
"normalized": []
},
{
"id": "NCT02715466_exc_T22",
"type": "Condition",
"text": [
"Acutely burned"
],
"offsets": [
[
639,
653
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02715466_exc_R1",
"type": "Has_multiplier",
"arg1_id": "NCT02715466_exc_T4",
"arg2_id": "NCT02715466_exc_T3",
"normalized": []
},
{
"id": "NCT02715466_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02715466_exc_T6",
"arg2_id": "NCT02715466_exc_T5",
"normalized": []
},
{
"id": "NCT02715466_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02715466_exc_T7",
"arg2_id": "NCT02715466_exc_T8",
"normalized": []
},
{
"id": "NCT02715466_exc_R4",
"type": "Has_value",
"arg1_id": "NCT02715466_exc_T10",
"arg2_id": "NCT02715466_exc_T11",
"normalized": []
},
{
"id": "NCT02715466_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT02715466_exc_T9",
"arg2_id": "NCT02715466_exc_T10",
"normalized": []
},
{
"id": "NCT02715466_exc_R6",
"type": "Subsumes",
"arg1_id": "NCT02715466_exc_T7",
"arg2_id": "NCT02715466_exc_T9",
"normalized": []
},
{
"id": "NCT02715466_exc_R7",
"type": "Has_mood",
"arg1_id": "NCT02715466_exc_T14",
"arg2_id": "NCT02715466_exc_T15",
"normalized": []
},
{
"id": "NCT02715466_exc_R9",
"type": "Has_value",
"arg1_id": "NCT02715466_exc_T19",
"arg2_id": "NCT02715466_exc_T20",
"normalized": []
},
{
"id": "NCT02715466_exc_R8",
"type": "Has_scope",
"arg1_id": "NCT02715466_exc_T16",
"arg2_id": "NCT02715466_exc_T21",
"normalized": []
}
] |
NCT02715466_inc
|
NCT02715466
|
[
{
"id": "NCT02715466_inc_text",
"type": "inclusion",
"text": [
"Male or female patients = 18 and = 85 years of age\nWomen of child bearing potential must test negative on standard pregnancy test (urine or serum)\nPatients with body weight = 55 kg and = 140 kg and body mass index (BMI) = 18 kg/m2\nPatients diagnosed severe sepsis / septic shock at admission on Intensive Care Unit who can be enrolled within 90 min after admission OR patients diagnosed severe sepsis / septic shock during Intensive Care Unit stay who can be enrolled within 90 min after diagnosis\nPatients where antibiotic therapy has already been started (prior to randomization)\nPatient who are fluid responsive. Fluid responsiveness is defined as increase of > 10% in mean arterial pressure (MAP) after passive leg raising (PLR)\nSigned informed consent by patient, legal representative or authorized person or deferred consent\n"
],
"offsets": [
[
0,
831
]
]
}
] |
[
{
"id": "NCT02715466_inc_T1",
"type": "Person",
"text": [
"Male"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T2",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
8,
14
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T3",
"type": "Value",
"text": [
"= 18 and = 85 years"
],
"offsets": [
[
24,
43
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T4",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
47,
50
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T5",
"type": "Person",
"text": [
"Women"
],
"offsets": [
[
51,
56
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T6",
"type": "Condition",
"text": [
"child bearing potential"
],
"offsets": [
[
60,
83
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T7",
"type": "Measurement",
"text": [
"standard pregnancy test"
],
"offsets": [
[
106,
129
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T8",
"type": "Value",
"text": [
"negative"
],
"offsets": [
[
94,
102
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T9",
"type": "Measurement",
"text": [
"urine"
],
"offsets": [
[
131,
136
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T10",
"type": "Measurement",
"text": [
"serum"
],
"offsets": [
[
140,
145
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T11",
"type": "Scope",
"text": [
"urine or serum"
],
"offsets": [
[
131,
145
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T12",
"type": "Scope",
"text": [
"Women of child bearing potential"
],
"offsets": [
[
51,
83
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T13",
"type": "Measurement",
"text": [
"body weight"
],
"offsets": [
[
161,
172
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T14",
"type": "Value",
"text": [
"= 55 kg and = 140 kg"
],
"offsets": [
[
173,
193
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T15",
"type": "Measurement",
"text": [
"body mass index (BMI)"
],
"offsets": [
[
198,
219
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T16",
"type": "Value",
"text": [
"= 18 kg/m2"
],
"offsets": [
[
220,
230
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T17",
"type": "Condition",
"text": [
"severe sepsis"
],
"offsets": [
[
250,
263
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T18",
"type": "Condition",
"text": [
"septic shock"
],
"offsets": [
[
266,
278
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T19",
"type": "Temporal",
"text": [
"at admission on Intensive Care Unit"
],
"offsets": [
[
279,
314
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T20",
"type": "Reference_point",
"text": [
"admission on Intensive Care Unit"
],
"offsets": [
[
282,
314
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T22",
"type": "Drug",
"text": [
"antibiotic therapy"
],
"offsets": [
[
513,
531
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T23",
"type": "Temporal",
"text": [
"prior to randomization"
],
"offsets": [
[
558,
580
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T24",
"type": "Reference_point",
"text": [
"randomization"
],
"offsets": [
[
567,
580
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T25",
"type": "Condition",
"text": [
"fluid responsive"
],
"offsets": [
[
598,
614
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T26",
"type": "Measurement",
"text": [
"mean arterial pressure (MAP)"
],
"offsets": [
[
672,
700
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T27",
"type": "Qualifier",
"text": [
"after passive leg raising (PLR)"
],
"offsets": [
[
701,
732
]
],
"normalized": []
},
{
"id": "NCT02715466_inc_T28",
"type": "Value",
"text": [
"> 10%"
],
"offsets": [
[
663,
668
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02715466_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02715466_inc_T4",
"arg2_id": "NCT02715466_inc_T3",
"normalized": []
},
{
"id": "NCT02715466_inc_R2",
"type": "Subsumes",
"arg1_id": "NCT02715466_inc_T7",
"arg2_id": "NCT02715466_inc_T11",
"normalized": []
},
{
"id": "NCT02715466_inc_R3",
"type": "Has_value",
"arg1_id": "NCT02715466_inc_T7",
"arg2_id": "NCT02715466_inc_T8",
"normalized": []
},
{
"id": "NCT02715466_inc_R4",
"type": "AND",
"arg1_id": "NCT02715466_inc_T12",
"arg2_id": "NCT02715466_inc_T7",
"normalized": []
},
{
"id": "NCT02715466_inc_R5",
"type": "Has_value",
"arg1_id": "NCT02715466_inc_T13",
"arg2_id": "NCT02715466_inc_T14",
"normalized": []
},
{
"id": "NCT02715466_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02715466_inc_T15",
"arg2_id": "NCT02715466_inc_T16",
"normalized": []
},
{
"id": "NCT02715466_inc_R7",
"type": "Has_temporal",
"arg1_id": "NCT02715466_inc_T18",
"arg2_id": "NCT02715466_inc_T19",
"normalized": []
},
{
"id": "NCT02715466_inc_R8",
"type": "Has_temporal",
"arg1_id": "NCT02715466_inc_T17",
"arg2_id": "NCT02715466_inc_T19",
"normalized": []
},
{
"id": "NCT02715466_inc_R9",
"type": "Has_index",
"arg1_id": "NCT02715466_inc_T19",
"arg2_id": "NCT02715466_inc_T20",
"normalized": []
},
{
"id": "NCT02715466_inc_R10",
"type": "Has_index",
"arg1_id": "NCT02715466_inc_T23",
"arg2_id": "NCT02715466_inc_T24",
"normalized": []
},
{
"id": "NCT02715466_inc_R11",
"type": "Has_temporal",
"arg1_id": "NCT02715466_inc_T22",
"arg2_id": "NCT02715466_inc_T23",
"normalized": []
},
{
"id": "NCT02715466_inc_R12",
"type": "Has_qualifier",
"arg1_id": "NCT02715466_inc_T26",
"arg2_id": "NCT02715466_inc_T27",
"normalized": []
},
{
"id": "NCT02715466_inc_R13",
"type": "Has_value",
"arg1_id": "NCT02715466_inc_T26",
"arg2_id": "NCT02715466_inc_T28",
"normalized": []
},
{
"id": "NCT02715466_inc_R14",
"type": "Subsumes",
"arg1_id": "NCT02715466_inc_T25",
"arg2_id": "NCT02715466_inc_T26",
"normalized": []
}
] |
NCT02715518_exc
|
NCT02715518
|
[
{
"id": "NCT02715518_exc_text",
"type": "exclusion",
"text": [
"NA\n"
],
"offsets": [
[
0,
3
]
]
}
] |
[] |
[] |
[] |
[] |
NCT02715518_inc
|
NCT02715518
|
[
{
"id": "NCT02715518_inc_text",
"type": "inclusion",
"text": [
"Symptoms of ischaemia.\nNew or presumed new significant ST-T wave changes\nDevelopment of pathological Q waves on ECG.\nImaging evidence of new or presumed new loss of viable myocardium or regional wall motion abnormality.\n"
],
"offsets": [
[
0,
220
]
]
}
] |
[
{
"id": "NCT02715518_inc_T1",
"type": "Mood",
"text": [
"Symptoms"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T2",
"type": "Condition",
"text": [
"ischaemia"
],
"offsets": [
[
12,
21
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T3",
"type": "Qualifier",
"text": [
"significant"
],
"offsets": [
[
43,
54
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T4",
"type": "Multiplier",
"text": [
"New"
],
"offsets": [
[
23,
26
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T5",
"type": "Multiplier",
"text": [
"presumed new"
],
"offsets": [
[
30,
42
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T6",
"type": "Condition",
"text": [
"ST-T wave changes"
],
"offsets": [
[
55,
72
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T7",
"type": "Scope",
"text": [
"significant ST-T wave changes"
],
"offsets": [
[
43,
72
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T8",
"type": "Scope",
"text": [
"New or presumed new"
],
"offsets": [
[
23,
42
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T9",
"type": "Scope",
"text": [
"significant ST-T wave changes"
],
"offsets": [
[
43,
72
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T10",
"type": "Condition",
"text": [
"pathological Q waves"
],
"offsets": [
[
88,
108
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T11",
"type": "Procedure",
"text": [
"ECG"
],
"offsets": [
[
112,
115
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T12",
"type": "Procedure",
"text": [
"Imaging"
],
"offsets": [
[
117,
124
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T13",
"type": "Condition",
"text": [
"evidence"
],
"offsets": [
[
125,
133
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T14",
"type": "Multiplier",
"text": [
"presumed new"
],
"offsets": [
[
144,
156
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T15",
"type": "Multiplier",
"text": [
"new"
],
"offsets": [
[
137,
140
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T16",
"type": "Condition",
"text": [
"loss of viable myocardium"
],
"offsets": [
[
157,
182
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T17",
"type": "Scope",
"text": [
"new or presumed new"
],
"offsets": [
[
137,
156
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T18",
"type": "Condition",
"text": [
"regional wall motion abnormality"
],
"offsets": [
[
186,
218
]
],
"normalized": []
},
{
"id": "NCT02715518_inc_T19",
"type": "Scope",
"text": [
"loss of viable myocardium or regional wall motion abnormality"
],
"offsets": [
[
157,
218
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02715518_inc_R1",
"type": "Has_mood",
"arg1_id": "NCT02715518_inc_T2",
"arg2_id": "NCT02715518_inc_T1",
"normalized": []
},
{
"id": "NCT02715518_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02715518_inc_T6",
"arg2_id": "NCT02715518_inc_T3",
"normalized": []
},
{
"id": "NCT02715518_inc_R3",
"type": "Has_scope",
"arg1_id": "NCT02715518_inc_T9",
"arg2_id": "NCT02715518_inc_T8",
"normalized": []
},
{
"id": "NCT02715518_inc_R4",
"type": "AND",
"arg1_id": "NCT02715518_inc_T11",
"arg2_id": "NCT02715518_inc_T10",
"normalized": []
},
{
"id": "NCT02715518_inc_R5",
"type": "AND",
"arg1_id": "NCT02715518_inc_T12",
"arg2_id": "NCT02715518_inc_T13",
"normalized": []
},
{
"id": "NCT02715518_inc_R7",
"type": "Has_scope",
"arg1_id": "NCT02715518_inc_T13",
"arg2_id": "NCT02715518_inc_T17",
"normalized": []
},
{
"id": "NCT02715518_inc_R6",
"type": "Has_scope",
"arg1_id": "NCT02715518_inc_T13",
"arg2_id": "NCT02715518_inc_T19",
"normalized": []
}
] |
NCT02721017_exc
|
NCT02721017
|
[
{
"id": "NCT02721017_exc_text",
"type": "exclusion",
"text": [
"age less than 13 years at time of procedure\nuse of pain medication prior to procedure\npectus carinatum, Poland's syndrome, or any chest wall anomaly other than pectus excavatum\nprevious repair of pectus excavatum by any technique\nprevious thoracic surgery\ncongenital heart disease\nbleeding dyscrasia\nmajor anesthetic risk factors or history of previous problem with anesthesia\npregnancy\ninability to communicate in English\n"
],
"offsets": [
[
0,
423
]
]
}
] |
[
{
"id": "NCT02721017_exc_T1",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T2",
"type": "Value",
"text": [
"less than 13 years"
],
"offsets": [
[
4,
22
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T3",
"type": "Temporal",
"text": [
"at time of procedure"
],
"offsets": [
[
23,
43
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T4",
"type": "Drug",
"text": [
"pain medication"
],
"offsets": [
[
51,
66
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T5",
"type": "Temporal",
"text": [
"prior to procedure"
],
"offsets": [
[
67,
85
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T6",
"type": "Condition",
"text": [
"pectus carinatum"
],
"offsets": [
[
86,
102
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T7",
"type": "Condition",
"text": [
"Poland's syndrome"
],
"offsets": [
[
104,
121
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T8",
"type": "Condition",
"text": [
"chest wall anomaly"
],
"offsets": [
[
130,
148
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T9",
"type": "Negation",
"text": [
"other than"
],
"offsets": [
[
149,
159
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T10",
"type": "Condition",
"text": [
"pectus excavatum"
],
"offsets": [
[
160,
176
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T11",
"type": "Procedure",
"text": [
"repair of pectus excavatum"
],
"offsets": [
[
186,
212
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T12",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
177,
185
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T13",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
230,
238
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T14",
"type": "Procedure",
"text": [
"thoracic surgery"
],
"offsets": [
[
239,
255
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T15",
"type": "Condition",
"text": [
"congenital heart disease"
],
"offsets": [
[
256,
280
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T16",
"type": "Condition",
"text": [
"bleeding dyscrasia"
],
"offsets": [
[
281,
299
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T17",
"type": "Condition",
"text": [
"anesthetic risk factors"
],
"offsets": [
[
306,
329
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T18",
"type": "Qualifier",
"text": [
"major"
],
"offsets": [
[
300,
305
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T19",
"type": "Condition",
"text": [
"problem with anesthesia"
],
"offsets": [
[
353,
376
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T20",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
344,
352
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T21",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
377,
386
]
],
"normalized": []
},
{
"id": "NCT02721017_exc_T22",
"type": "Condition",
"text": [
"inability to communicate in English"
],
"offsets": [
[
387,
422
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02721017_exc_R1",
"type": "Has_value",
"arg1_id": "NCT02721017_exc_T1",
"arg2_id": "NCT02721017_exc_T2",
"normalized": []
},
{
"id": "NCT02721017_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02721017_exc_T1",
"arg2_id": "NCT02721017_exc_T3",
"normalized": []
},
{
"id": "NCT02721017_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02721017_exc_T4",
"arg2_id": "NCT02721017_exc_T5",
"normalized": []
},
{
"id": "NCT02721017_exc_R4",
"type": "Has_negation",
"arg1_id": "NCT02721017_exc_T10",
"arg2_id": "NCT02721017_exc_T9",
"normalized": []
},
{
"id": "NCT02721017_exc_R5",
"type": "AND",
"arg1_id": "NCT02721017_exc_T8",
"arg2_id": "NCT02721017_exc_T10",
"normalized": []
},
{
"id": "NCT02721017_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02721017_exc_T11",
"arg2_id": "NCT02721017_exc_T12",
"normalized": []
},
{
"id": "NCT02721017_exc_R7",
"type": "Has_temporal",
"arg1_id": "NCT02721017_exc_T14",
"arg2_id": "NCT02721017_exc_T13",
"normalized": []
},
{
"id": "NCT02721017_exc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT02721017_exc_T17",
"arg2_id": "NCT02721017_exc_T18",
"normalized": []
},
{
"id": "NCT02721017_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT02721017_exc_T19",
"arg2_id": "NCT02721017_exc_T20",
"normalized": []
}
] |
NCT02721017_inc
|
NCT02721017
|
[
{
"id": "NCT02721017_inc_text",
"type": "inclusion",
"text": [
"scheduled for Nuss procedure for pectus excavatum correction\nat least 13 years old at the time of the procedure\n"
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "NCT02721017_inc_T1",
"type": "Procedure",
"text": [
"Nuss procedure"
],
"offsets": [
[
14,
28
]
],
"normalized": []
},
{
"id": "NCT02721017_inc_T2",
"type": "Mood",
"text": [
"scheduled"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "NCT02721017_inc_T3",
"type": "Condition",
"text": [
"pectus excavatum"
],
"offsets": [
[
33,
49
]
],
"normalized": []
},
{
"id": "NCT02721017_inc_T4",
"type": "Value",
"text": [
"at least 13 years"
],
"offsets": [
[
61,
78
]
],
"normalized": []
},
{
"id": "NCT02721017_inc_T5",
"type": "Person",
"text": [
"old"
],
"offsets": [
[
79,
82
]
],
"normalized": []
},
{
"id": "NCT02721017_inc_T6",
"type": "Temporal",
"text": [
"at the time of the procedure"
],
"offsets": [
[
83,
111
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02721017_inc_R1",
"type": "AND",
"arg1_id": "NCT02721017_inc_T1",
"arg2_id": "NCT02721017_inc_T3",
"normalized": []
},
{
"id": "NCT02721017_inc_R2",
"type": "Has_mood",
"arg1_id": "NCT02721017_inc_T1",
"arg2_id": "NCT02721017_inc_T2",
"normalized": []
},
{
"id": "NCT02721017_inc_R3",
"type": "Has_value",
"arg1_id": "NCT02721017_inc_T5",
"arg2_id": "NCT02721017_inc_T4",
"normalized": []
},
{
"id": "NCT02721017_inc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02721017_inc_T5",
"arg2_id": "NCT02721017_inc_T6",
"normalized": []
}
] |
NCT02726009_exc
|
NCT02726009
|
[
{
"id": "NCT02726009_exc_text",
"type": "exclusion",
"text": [
"Previous or concurrent hormonal management of prostate cancer\nContraindication for prescription of Firmagon®\nConcurrent treatment with a 5-a-reductase inhibitor\nConsidered as a candidate for curative therapy\nHistory of severe untreated asthma, anaphylactic reactions or severe urticaria and/or angioedema\nQTc interval over 450 msec or risk factors for torsades de pointes or on Class IA and Class III anti arrhythmic medications\nCancer within the last 5 years except prostate cancer and surgically removed basal or squamous cell carcinoma of the skin\nKnown or suspected hepatic, symptomatic biliary disease (this includes moderate to severe chronic hepatic impairment)\nPatients with clinically significant laboratory abnormalities / disorders other than prostate cancer\nPatient with Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) infections\n"
],
"offsets": [
[
0,
882
]
]
}
] |
[
{
"id": "NCT02726009_exc_T1",
"type": "Procedure",
"text": [
"hormonal management"
],
"offsets": [
[
23,
42
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T2",
"type": "Condition",
"text": [
"prostate cancer"
],
"offsets": [
[
46,
61
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T3",
"type": "Condition",
"text": [
"Contraindication"
],
"offsets": [
[
62,
78
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T4",
"type": "Drug",
"text": [
"Firmagon"
],
"offsets": [
[
99,
107
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T5",
"type": "Drug",
"text": [
"5-a-reductase inhibitor"
],
"offsets": [
[
137,
160
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T6",
"type": "Procedure",
"text": [
"curative therapy"
],
"offsets": [
[
191,
207
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T7",
"type": "Condition",
"text": [
"asthma"
],
"offsets": [
[
236,
242
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T8",
"type": "Qualifier",
"text": [
"untreated"
],
"offsets": [
[
226,
235
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T9",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
219,
225
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T10",
"type": "Condition",
"text": [
"anaphylactic reactions"
],
"offsets": [
[
244,
266
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T11",
"type": "Condition",
"text": [
"urticaria"
],
"offsets": [
[
277,
286
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T12",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
270,
276
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T13",
"type": "Condition",
"text": [
"angioedema"
],
"offsets": [
[
294,
304
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T14",
"type": "Measurement",
"text": [
"QTc interval"
],
"offsets": [
[
305,
317
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T15",
"type": "Value",
"text": [
"over 450 msec"
],
"offsets": [
[
318,
331
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T16",
"type": "Observation",
"text": [
"risk factors for torsades de pointes"
],
"offsets": [
[
335,
371
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T17",
"type": "Drug",
"text": [
"Class III anti arrhythmic medications"
],
"offsets": [
[
391,
428
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T18",
"type": "Drug",
"text": [
" IA an",
"arrhythmic medications\nCanc"
],
"offsets": [
[
383,
389
],
[
406,
433
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T19",
"type": "Condition",
"text": [
"Cancer"
],
"offsets": [
[
429,
435
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T20",
"type": "Temporal",
"text": [
"last 5 years"
],
"offsets": [
[
447,
459
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T21",
"type": "Negation",
"text": [
"except"
],
"offsets": [
[
460,
466
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T22",
"type": "Condition",
"text": [
"prostate cancer"
],
"offsets": [
[
467,
482
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T23",
"type": "Condition",
"text": [
"squamous cell carcinoma of the skin"
],
"offsets": [
[
515,
550
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T24",
"type": "Condition",
"text": [
"or sq",
"arcinoma of the skin\nKnown"
],
"offsets": [
[
512,
517
],
[
530,
556
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T25",
"type": "Procedure",
"text": [
"surgically"
],
"offsets": [
[
487,
497
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T26",
"type": "Scope",
"text": [
"basal or squamous cell carcinoma of the skin"
],
"offsets": [
[
506,
550
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T27",
"type": "Scope",
"text": [
"prostate cancer and surgically removed basal or squamous cell carcinoma of the skin"
],
"offsets": [
[
467,
550
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T28",
"type": "Condition",
"text": [
"biliary disease"
],
"offsets": [
[
591,
606
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T29",
"type": "Condition",
"text": [
", sympt",
" (thi"
],
"offsets": [
[
577,
584
],
[
606,
611
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T30",
"type": "Qualifier",
"text": [
"moderate"
],
"offsets": [
[
622,
630
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T31",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
634,
640
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T32",
"type": "Condition",
"text": [
"chronic hepatic impairment"
],
"offsets": [
[
641,
667
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T33",
"type": "Scope",
"text": [
"moderate to severe"
],
"offsets": [
[
622,
640
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T35",
"type": "Condition",
"text": [
" B Virus (HBV), ",
"s"
],
"offsets": [
[
792,
808
],
[
880,
881
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T36",
"type": "Condition",
"text": [
" C Virus (HCV) a",
"s"
],
"offsets": [
[
817,
833
],
[
880,
881
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T37",
"type": "Condition",
"text": [
"HBV"
],
"offsets": [
[
802,
805
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T38",
"type": "Condition",
"text": [
"HCV"
],
"offsets": [
[
827,
830
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T39",
"type": "Condition",
"text": [
"unodeficiency Virus (HIV) in",
"s"
],
"offsets": [
[
845,
873
],
[
880,
881
]
],
"normalized": []
},
{
"id": "NCT02726009_exc_T40",
"type": "Condition",
"text": [
"HIV"
],
"offsets": [
[
866,
869
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02726009_exc_R1",
"type": "AND",
"arg1_id": "NCT02726009_exc_T1",
"arg2_id": "NCT02726009_exc_T2",
"normalized": []
},
{
"id": "NCT02726009_exc_R2",
"type": "AND",
"arg1_id": "NCT02726009_exc_T3",
"arg2_id": "NCT02726009_exc_T4",
"normalized": []
},
{
"id": "NCT02726009_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02726009_exc_T11",
"arg2_id": "NCT02726009_exc_T12",
"normalized": []
},
{
"id": "NCT02726009_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02726009_exc_T7",
"arg2_id": "NCT02726009_exc_T8",
"normalized": []
},
{
"id": "NCT02726009_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02726009_exc_T7",
"arg2_id": "NCT02726009_exc_T9",
"normalized": []
},
{
"id": "NCT02726009_exc_R6",
"type": "Has_value",
"arg1_id": "NCT02726009_exc_T14",
"arg2_id": "NCT02726009_exc_T15",
"normalized": []
},
{
"id": "NCT02726009_exc_R7",
"type": "Has_temporal",
"arg1_id": "NCT02726009_exc_T19",
"arg2_id": "NCT02726009_exc_T20",
"normalized": []
},
{
"id": "NCT02726009_exc_R8",
"type": "AND",
"arg1_id": "NCT02726009_exc_T26",
"arg2_id": "NCT02726009_exc_T25",
"normalized": []
},
{
"id": "NCT02726009_exc_R9",
"type": "Has_negation",
"arg1_id": "NCT02726009_exc_T27",
"arg2_id": "NCT02726009_exc_T21",
"normalized": []
},
{
"id": "NCT02726009_exc_R10",
"type": "Has_scope",
"arg1_id": "NCT02726009_exc_T32",
"arg2_id": "NCT02726009_exc_T33",
"normalized": []
},
{
"id": "NCT02726009_exc_R11",
"type": "Subsumes",
"arg1_id": "NCT02726009_exc_T29",
"arg2_id": "NCT02726009_exc_T32",
"normalized": []
},
{
"id": "NCT02726009_exc_R12",
"type": "Subsumes",
"arg1_id": "NCT02726009_exc_T35",
"arg2_id": "NCT02726009_exc_T37",
"normalized": []
},
{
"id": "NCT02726009_exc_R13",
"type": "Subsumes",
"arg1_id": "NCT02726009_exc_T36",
"arg2_id": "NCT02726009_exc_T38",
"normalized": []
},
{
"id": "NCT02726009_exc_R14",
"type": "Subsumes",
"arg1_id": "NCT02726009_exc_T39",
"arg2_id": "NCT02726009_exc_T40",
"normalized": []
}
] |
NCT02726009_inc
|
NCT02726009
|
[
{
"id": "NCT02726009_inc_text",
"type": "inclusion",
"text": [
"Has given written informed consent before any study-related activity is performed\nAdvanced hormone-dependent prostate cancer for which androgen deprivation therapy is indicated, and independently from this trial, Firmagon® is intended to be used for treatment\nAge greater than or equal to 18 years and less than 80 years\nAdvanced hormone-dependent prostate cancer without any other clinically significant disorder\nEasten Cooperative Oncology Group score = 2\nPSA = 2 ng/mL at screening\nLife expectancy of at least 12 months as per the investigator's judgement\n"
],
"offsets": [
[
0,
559
]
]
}
] |
[
{
"id": "NCT02726009_inc_T2",
"type": "Qualifier",
"text": [
"hormone-dependent"
],
"offsets": [
[
91,
108
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T3",
"type": "Qualifier",
"text": [
"Advanced"
],
"offsets": [
[
82,
90
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T4",
"type": "Condition",
"text": [
"prostate cancer"
],
"offsets": [
[
109,
124
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T5",
"type": "Procedure",
"text": [
"androgen deprivation therapy"
],
"offsets": [
[
135,
163
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T6",
"type": "Drug",
"text": [
"Firmagon"
],
"offsets": [
[
213,
221
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T7",
"type": "Mood",
"text": [
"intended"
],
"offsets": [
[
226,
234
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T8",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
260,
263
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T9",
"type": "Value",
"text": [
"greater than or equal to 18 years and less than 80 years"
],
"offsets": [
[
264,
320
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T10",
"type": "Qualifier",
"text": [
"Advanced"
],
"offsets": [
[
321,
329
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T11",
"type": "Qualifier",
"text": [
"hormone-dependent"
],
"offsets": [
[
330,
347
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T12",
"type": "Condition",
"text": [
"prostate cancer"
],
"offsets": [
[
348,
363
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T14",
"type": "Measurement",
"text": [
"Easten Cooperative Oncology Group score"
],
"offsets": [
[
414,
453
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T15",
"type": "Value",
"text": [
"= 2"
],
"offsets": [
[
454,
457
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T16",
"type": "Measurement",
"text": [
"PSA"
],
"offsets": [
[
458,
461
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T17",
"type": "Value",
"text": [
"= 2 ng/mL"
],
"offsets": [
[
462,
471
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T18",
"type": "Observation",
"text": [
"Life expectancy"
],
"offsets": [
[
485,
500
]
],
"normalized": []
},
{
"id": "NCT02726009_inc_T19",
"type": "Value",
"text": [
"at least 12 months"
],
"offsets": [
[
504,
522
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02726009_inc_R1",
"type": "AND",
"arg1_id": "NCT02726009_inc_T4",
"arg2_id": "NCT02726009_inc_T5",
"normalized": []
},
{
"id": "NCT02726009_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02726009_inc_T4",
"arg2_id": "NCT02726009_inc_T2",
"normalized": []
},
{
"id": "NCT02726009_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02726009_inc_T4",
"arg2_id": "NCT02726009_inc_T3",
"normalized": []
},
{
"id": "NCT02726009_inc_R4",
"type": "Has_mood",
"arg1_id": "NCT02726009_inc_T6",
"arg2_id": "NCT02726009_inc_T7",
"normalized": []
},
{
"id": "NCT02726009_inc_R5",
"type": "AND",
"arg1_id": "NCT02726009_inc_T4",
"arg2_id": "NCT02726009_inc_T6",
"normalized": []
},
{
"id": "NCT02726009_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02726009_inc_T8",
"arg2_id": "NCT02726009_inc_T9",
"normalized": []
},
{
"id": "NCT02726009_inc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02726009_inc_T12",
"arg2_id": "NCT02726009_inc_T11",
"normalized": []
},
{
"id": "NCT02726009_inc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT02726009_inc_T12",
"arg2_id": "NCT02726009_inc_T10",
"normalized": []
},
{
"id": "NCT02726009_inc_R9",
"type": "Has_value",
"arg1_id": "NCT02726009_inc_T14",
"arg2_id": "NCT02726009_inc_T15",
"normalized": []
},
{
"id": "NCT02726009_inc_R10",
"type": "Has_value",
"arg1_id": "NCT02726009_inc_T16",
"arg2_id": "NCT02726009_inc_T17",
"normalized": []
},
{
"id": "NCT02726009_inc_R11",
"type": "Has_value",
"arg1_id": "NCT02726009_inc_T18",
"arg2_id": "NCT02726009_inc_T19",
"normalized": []
}
] |
NCT02731794_exc
|
NCT02731794
|
[
{
"id": "NCT02731794_exc_text",
"type": "exclusion",
"text": [
"myocardial infarction within the preceding 4 weeks\nsevere valve disease requiring valve replacement\ncardiac reoperations\n"
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "NCT02731794_exc_T1",
"type": "Condition",
"text": [
"myocardial infarction"
],
"offsets": [
[
0,
21
]
],
"normalized": []
},
{
"id": "NCT02731794_exc_T2",
"type": "Temporal",
"text": [
"within the preceding 4 weeks"
],
"offsets": [
[
22,
50
]
],
"normalized": []
},
{
"id": "NCT02731794_exc_T3",
"type": "Reference_point",
"text": [
"the preceding 4 weeks"
],
"offsets": [
[
29,
50
]
],
"normalized": []
},
{
"id": "NCT02731794_exc_T4",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
51,
57
]
],
"normalized": []
},
{
"id": "NCT02731794_exc_T5",
"type": "Condition",
"text": [
"valve disease"
],
"offsets": [
[
58,
71
]
],
"normalized": []
},
{
"id": "NCT02731794_exc_T6",
"type": "Qualifier",
"text": [
"requiring valve replacement"
],
"offsets": [
[
72,
99
]
],
"normalized": []
},
{
"id": "NCT02731794_exc_T7",
"type": "Procedure",
"text": [
"valve replacement"
],
"offsets": [
[
82,
99
]
],
"normalized": []
},
{
"id": "NCT02731794_exc_T8",
"type": "Procedure",
"text": [
"cardiac reoperations"
],
"offsets": [
[
100,
120
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02731794_exc_R1",
"type": "Has_temporal",
"arg1_id": "NCT02731794_exc_T1",
"arg2_id": "NCT02731794_exc_T2",
"normalized": []
},
{
"id": "NCT02731794_exc_R2",
"type": "Has_index",
"arg1_id": "NCT02731794_exc_T2",
"arg2_id": "NCT02731794_exc_T3",
"normalized": []
},
{
"id": "NCT02731794_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02731794_exc_T5",
"arg2_id": "NCT02731794_exc_T4",
"normalized": []
},
{
"id": "NCT02731794_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02731794_exc_T5",
"arg2_id": "NCT02731794_exc_T6",
"normalized": []
}
] |
NCT02731794_inc
|
NCT02731794
|
[
{
"id": "NCT02731794_inc_text",
"type": "inclusion",
"text": [
"patients with severe left ventricle dysfunction with an ejection fraction (EF)=40%, being scheduled for revascularization.\n"
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "NCT02731794_inc_T1",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
14,
20
]
],
"normalized": []
},
{
"id": "NCT02731794_inc_T2",
"type": "Condition",
"text": [
"left ventricle dysfunction"
],
"offsets": [
[
21,
47
]
],
"normalized": []
},
{
"id": "NCT02731794_inc_T3",
"type": "Measurement",
"text": [
"ejection fraction (EF)"
],
"offsets": [
[
56,
78
]
],
"normalized": []
},
{
"id": "NCT02731794_inc_T4",
"type": "Value",
"text": [
"=40%"
],
"offsets": [
[
78,
82
]
],
"normalized": []
},
{
"id": "NCT02731794_inc_T5",
"type": "Observation",
"text": [
"being scheduled for"
],
"offsets": [
[
84,
103
]
],
"normalized": []
},
{
"id": "NCT02731794_inc_T6",
"type": "Procedure",
"text": [
"revascularization"
],
"offsets": [
[
104,
121
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02731794_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02731794_inc_T3",
"arg2_id": "NCT02731794_inc_T4",
"normalized": []
},
{
"id": "NCT02731794_inc_R2",
"type": "AND",
"arg1_id": "NCT02731794_inc_T5",
"arg2_id": "NCT02731794_inc_T6",
"normalized": []
},
{
"id": "NCT02731794_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02731794_inc_T2",
"arg2_id": "NCT02731794_inc_T1",
"normalized": []
}
] |
NCT02732080_exc
|
NCT02732080
|
[
{
"id": "NCT02732080_exc_text",
"type": "exclusion",
"text": [
"Recanalized (TIMI I-III flow) IRA at coronary angiography.\nPatients in whom TIMI-3 flow was not able to be established after wire crossing, balloon angioplasty or thrombectomy.\nSTEMI due to bypass-graft occlusion\nSevere heart failure or cardiogenic shock\n"
],
"offsets": [
[
0,
255
]
]
}
] |
[
{
"id": "NCT02732080_exc_T1",
"type": "Procedure",
"text": [
"Recanalized"
],
"offsets": [
[
0,
11
]
],
"normalized": []
},
{
"id": "NCT02732080_exc_T4",
"type": "Condition",
"text": [
"IRA"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "NCT02732080_exc_T5",
"type": "Procedure",
"text": [
"coronary angiography"
],
"offsets": [
[
37,
57
]
],
"normalized": []
},
{
"id": "NCT02732080_exc_T2",
"type": "Qualifier",
"text": [
"TIMI I-III flow"
],
"offsets": [
[
13,
28
]
],
"normalized": []
},
{
"id": "NCT02732080_exc_T6",
"type": "Condition",
"text": [
"STEMI"
],
"offsets": [
[
177,
182
]
],
"normalized": []
},
{
"id": "NCT02732080_exc_T7",
"type": "Device",
"text": [
"bypass-graft"
],
"offsets": [
[
190,
202
]
],
"normalized": []
},
{
"id": "NCT02732080_exc_T8",
"type": "Condition",
"text": [
"occlusion"
],
"offsets": [
[
203,
212
]
],
"normalized": []
},
{
"id": "NCT02732080_exc_T9",
"type": "Qualifier",
"text": [
"Severe"
],
"offsets": [
[
213,
219
]
],
"normalized": []
},
{
"id": "NCT02732080_exc_T10",
"type": "Condition",
"text": [
"heart failure"
],
"offsets": [
[
220,
233
]
],
"normalized": []
},
{
"id": "NCT02732080_exc_T11",
"type": "Condition",
"text": [
"cardiogenic shock"
],
"offsets": [
[
237,
254
]
],
"normalized": []
},
{
"id": "NCT02732080_exc_T12",
"type": "Scope",
"text": [
"heart failure or cardiogenic shock"
],
"offsets": [
[
220,
254
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02732080_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02732080_exc_T1",
"arg2_id": "NCT02732080_exc_T2",
"normalized": []
},
{
"id": "NCT02732080_exc_R2",
"type": "AND",
"arg1_id": "NCT02732080_exc_T1",
"arg2_id": "NCT02732080_exc_T4",
"normalized": []
},
{
"id": "NCT02732080_exc_R3",
"type": "AND",
"arg1_id": "NCT02732080_exc_T8",
"arg2_id": "NCT02732080_exc_T7",
"normalized": []
},
{
"id": "NCT02732080_exc_R4",
"type": "AND",
"arg1_id": "NCT02732080_exc_T6",
"arg2_id": "NCT02732080_exc_T8",
"normalized": []
},
{
"id": "NCT02732080_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02732080_exc_T12",
"arg2_id": "NCT02732080_exc_T9",
"normalized": []
}
] |
NCT02732080_inc
|
NCT02732080
|
[
{
"id": "NCT02732080_inc_text",
"type": "inclusion",
"text": [
"Patients presenting with ST-elevation acute myocardial infarction (STEMI) within 12 hours of their symptom onset in whom TIMI-3 flow was established in infarct related artery (IRA) after balloon angioplasty or thrombectomy.\n"
],
"offsets": [
[
0,
224
]
]
}
] |
[
{
"id": "NCT02732080_inc_T1",
"type": "Condition",
"text": [
"ST-elevation acute myocardial infarction (STEMI)"
],
"offsets": [
[
25,
73
]
],
"normalized": []
},
{
"id": "NCT02732080_inc_T2",
"type": "Temporal",
"text": [
"within 12 hours of their symptom onset"
],
"offsets": [
[
74,
112
]
],
"normalized": []
},
{
"id": "NCT02732080_inc_T4",
"type": "Reference_point",
"text": [
"their symptom onset"
],
"offsets": [
[
93,
112
]
],
"normalized": []
},
{
"id": "NCT02732080_inc_T3",
"type": "Observation",
"text": [
"TIMI-3 flow was established"
],
"offsets": [
[
121,
148
]
],
"normalized": []
},
{
"id": "NCT02732080_inc_T5",
"type": "Qualifier",
"text": [
"infarct related artery (IRA)"
],
"offsets": [
[
152,
180
]
],
"normalized": []
},
{
"id": "NCT02732080_inc_T6",
"type": "Temporal",
"text": [
"after balloon angioplasty or thrombectomy"
],
"offsets": [
[
181,
222
]
],
"normalized": []
},
{
"id": "NCT02732080_inc_T7",
"type": "Procedure",
"text": [
"balloon angioplasty"
],
"offsets": [
[
187,
206
]
],
"normalized": []
},
{
"id": "NCT02732080_inc_T8",
"type": "Procedure",
"text": [
"thrombectomy"
],
"offsets": [
[
210,
222
]
],
"normalized": []
},
{
"id": "NCT02732080_inc_T9",
"type": "Reference_point",
"text": [
"balloon angioplasty or thrombectomy"
],
"offsets": [
[
187,
222
]
],
"normalized": []
},
{
"id": "NCT02732080_inc_T10",
"type": "Scope",
"text": [
"balloon angioplasty or thrombectomy"
],
"offsets": [
[
187,
222
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02732080_inc_R1",
"type": "Has_temporal",
"arg1_id": "NCT02732080_inc_T1",
"arg2_id": "NCT02732080_inc_T2",
"normalized": []
},
{
"id": "NCT02732080_inc_R2",
"type": "Has_index",
"arg1_id": "NCT02732080_inc_T2",
"arg2_id": "NCT02732080_inc_T4",
"normalized": []
},
{
"id": "NCT02732080_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02732080_inc_T3",
"arg2_id": "NCT02732080_inc_T5",
"normalized": []
},
{
"id": "NCT02732080_inc_R4",
"type": "Has_index",
"arg1_id": "NCT02732080_inc_T6",
"arg2_id": "NCT02732080_inc_T9",
"normalized": []
},
{
"id": "NCT02732080_inc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02732080_inc_T3",
"arg2_id": "NCT02732080_inc_T6",
"normalized": []
}
] |
NCT02733159_exc
|
NCT02733159
|
[
{
"id": "NCT02733159_exc_text",
"type": "exclusion",
"text": [
"Untreated symptomatic brain or leptomeningeal metastatic disease. \nMedical or psychiatric conditions comprising informed consent. \nAny medical condition which in the opinion of the investigator would compromise the ability of the patient to participate in the trial or which would jeopardise compliance with the protocol. \nRadiotherapy within 4 weeks of trial entry. \nActive autoimmune disease that has required systemic treatment in past 2 years \nChronic usage of steroids or other immunosuppressant medication. \nPrevious history of pneumonitis. \nAny evidence of clinical autoimmunity. \n \n"
],
"offsets": [
[
0,
599
]
]
}
] |
[
{
"id": "NCT02733159_exc_T1",
"type": "Condition",
"text": [
"symptomatic brain",
"metastatic disease"
],
"offsets": [
[
10,
27
],
[
46,
64
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T2",
"type": "Condition",
"text": [
"symptomatic",
"leptomeningeal metastatic disease"
],
"offsets": [
[
10,
21
],
[
31,
64
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T3",
"type": "Qualifier",
"text": [
"Untreated"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T4",
"type": "Condition",
"text": [
"psychiatric conditions"
],
"offsets": [
[
78,
100
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T6",
"type": "Condition",
"text": [
"Medical",
"conditions"
],
"offsets": [
[
67,
74
],
[
90,
100
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T11",
"type": "Procedure",
"text": [
"Radiotherapy"
],
"offsets": [
[
323,
335
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T12",
"type": "Temporal",
"text": [
"within 4 weeks of trial entry"
],
"offsets": [
[
336,
365
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T13",
"type": "Reference_point",
"text": [
"trial entry"
],
"offsets": [
[
354,
365
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T14",
"type": "Condition",
"text": [
"autoimmune disease"
],
"offsets": [
[
375,
393
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T15",
"type": "Temporal",
"text": [
"Active"
],
"offsets": [
[
368,
374
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T16",
"type": "Procedure",
"text": [
"systemic treatment"
],
"offsets": [
[
412,
430
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T17",
"type": "Temporal",
"text": [
"in past 2 years"
],
"offsets": [
[
431,
446
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T18",
"type": "Drug",
"text": [
"steroids"
],
"offsets": [
[
465,
473
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T19",
"type": "Multiplier",
"text": [
"Chronic usage"
],
"offsets": [
[
448,
461
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T20",
"type": "Drug",
"text": [
"immunosuppressant medication"
],
"offsets": [
[
483,
511
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T22",
"type": "Condition",
"text": [
"pneumonitis"
],
"offsets": [
[
534,
545
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T23",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
523,
530
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T24",
"type": "Condition",
"text": [
"autoimmunity"
],
"offsets": [
[
573,
585
]
],
"normalized": []
},
{
"id": "NCT02733159_exc_T25",
"type": "Condition",
"text": [
"Any evidence of clinical autoimmunity"
],
"offsets": [
[
548,
585
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02733159_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02733159_exc_T2",
"arg2_id": "NCT02733159_exc_T3",
"normalized": []
},
{
"id": "NCT02733159_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02733159_exc_T2",
"arg2_id": "NCT02733159_exc_T3",
"normalized": []
},
{
"id": "NCT02733159_exc_R3",
"type": "Has_index",
"arg1_id": "NCT02733159_exc_T12",
"arg2_id": "NCT02733159_exc_T13",
"normalized": []
},
{
"id": "NCT02733159_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02733159_exc_T11",
"arg2_id": "NCT02733159_exc_T12",
"normalized": []
},
{
"id": "NCT02733159_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02733159_exc_T14",
"arg2_id": "NCT02733159_exc_T15",
"normalized": []
},
{
"id": "NCT02733159_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02733159_exc_T16",
"arg2_id": "NCT02733159_exc_T17",
"normalized": []
},
{
"id": "NCT02733159_exc_R7",
"type": "AND",
"arg1_id": "NCT02733159_exc_T14",
"arg2_id": "NCT02733159_exc_T16",
"normalized": []
},
{
"id": "NCT02733159_exc_R8",
"type": "Has_multiplier",
"arg1_id": "NCT02733159_exc_T18",
"arg2_id": "NCT02733159_exc_T19",
"normalized": []
},
{
"id": "NCT02733159_exc_R9",
"type": "Has_multiplier",
"arg1_id": "NCT02733159_exc_T20",
"arg2_id": "NCT02733159_exc_T19",
"normalized": []
},
{
"id": "NCT02733159_exc_R10",
"type": "Has_temporal",
"arg1_id": "NCT02733159_exc_T22",
"arg2_id": "NCT02733159_exc_T23",
"normalized": []
}
] |
NCT02733159_inc
|
NCT02733159
|
[
{
"id": "NCT02733159_inc_text",
"type": "inclusion",
"text": [
"Histologically confirmed PD-L1 status defined NSCLC. Biopsy must be within 70 days of first treatment with pembrolizumab. \nECOG performance status 2. \nLife expectancy > 12 weeks. \nUni-dimensionally measurable disease according to Response Evaluation Criteria in Solid Tumours (RECIST) v1.1 \nComputerised Tomography (CT) scan of chest and abdomen within 28 days of starting pembrolizumab. \nAdequate haematological function: \nPlatelet count ≥100 x 109 /L. \nNeutrophils ≥1.5 x 109/L. \nHaemoglobin ≥ 9g/dL. \nAdequate hepatic function: \nSerum bilirubin ≤1.5 x upper limit of normal (ULN). \nSerum transaminases ≤2.5 x ULN. \nAdequate renal function: Creatinine clearance <1.5 times ULN concurrent with creatinine clearance >50 ml/min. \nProvision of signed and dated, written informed consent prior to any study specific procedures, sampling and analyses. \n"
],
"offsets": [
[
0,
849
]
]
}
] |
[
{
"id": "NCT02733159_inc_T1",
"type": "Condition",
"text": [
"NSCLC"
],
"offsets": [
[
46,
51
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T2",
"type": "Qualifier",
"text": [
"PD-L1 status"
],
"offsets": [
[
25,
37
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T3",
"type": "Procedure",
"text": [
"Biopsy"
],
"offsets": [
[
53,
59
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T4",
"type": "Temporal",
"text": [
"within 70 days of first treatment"
],
"offsets": [
[
68,
101
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T5",
"type": "Reference_point",
"text": [
"first treatment with pembrolizumab"
],
"offsets": [
[
86,
120
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T6",
"type": "Drug",
"text": [
"pembrolizumab"
],
"offsets": [
[
107,
120
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T7",
"type": "Measurement",
"text": [
"ECOG performance status"
],
"offsets": [
[
123,
146
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T8",
"type": "Value",
"text": [
"2"
],
"offsets": [
[
147,
148
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T9",
"type": "Observation",
"text": [
"Life expectancy"
],
"offsets": [
[
151,
166
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T10",
"type": "Measurement",
"text": [
"Response Evaluation Criteria in Solid Tumours (RECIST) v1.1"
],
"offsets": [
[
230,
289
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T11",
"type": "Value",
"text": [
"Uni-dimensionally measurable"
],
"offsets": [
[
180,
208
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T12",
"type": "Condition",
"text": [
"disease"
],
"offsets": [
[
209,
216
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T14",
"type": "Procedure",
"text": [
"Computerised Tomography (CT) scan of chest and abdomen"
],
"offsets": [
[
291,
345
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T15",
"type": "Temporal",
"text": [
"within 28 days of starting pembrolizumab"
],
"offsets": [
[
346,
386
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T16",
"type": "Reference_point",
"text": [
"starting pembrolizumab"
],
"offsets": [
[
364,
386
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T17",
"type": "Drug",
"text": [
"pembrolizumab"
],
"offsets": [
[
373,
386
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T18",
"type": "Measurement",
"text": [
"Platelet count"
],
"offsets": [
[
424,
438
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T19",
"type": "Value",
"text": [
"≥100 x 109 /L"
],
"offsets": [
[
439,
452
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T20",
"type": "Measurement",
"text": [
"Neutrophils"
],
"offsets": [
[
455,
466
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T21",
"type": "Value",
"text": [
"≥1.5 x 109/L"
],
"offsets": [
[
467,
479
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T22",
"type": "Measurement",
"text": [
"Haemoglobin"
],
"offsets": [
[
482,
493
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T23",
"type": "Value",
"text": [
"≥ 9g/dL"
],
"offsets": [
[
494,
501
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T26",
"type": "Measurement",
"text": [
"Serum bilirubin"
],
"offsets": [
[
532,
547
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T27",
"type": "Value",
"text": [
"≤1.5 x upper limit of normal (ULN)"
],
"offsets": [
[
548,
582
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T28",
"type": "Measurement",
"text": [
"Serum transaminases"
],
"offsets": [
[
585,
604
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T29",
"type": "Value",
"text": [
"≤2.5 x ULN"
],
"offsets": [
[
605,
615
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T30",
"type": "Measurement",
"text": [
"Creatinine clearance"
],
"offsets": [
[
643,
663
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T31",
"type": "Value",
"text": [
"<1.5 times ULN"
],
"offsets": [
[
664,
678
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T32",
"type": "Temporal",
"text": [
"concurrent"
],
"offsets": [
[
679,
689
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T33",
"type": "Measurement",
"text": [
"creatinine clearance"
],
"offsets": [
[
695,
715
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T34",
"type": "Value",
"text": [
">50 ml/min"
],
"offsets": [
[
716,
726
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T35",
"type": "Measurement",
"text": [
"renal function"
],
"offsets": [
[
627,
641
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T36",
"type": "Value",
"text": [
"Adequate"
],
"offsets": [
[
618,
626
]
],
"normalized": []
},
{
"id": "NCT02733159_inc_T37",
"type": "Scope",
"text": [
"Creatinine clearance <1.5 times ULN concurrent with creatinine clearance >50 ml/min"
],
"offsets": [
[
643,
726
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02733159_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02733159_inc_T1",
"arg2_id": "NCT02733159_inc_T2",
"normalized": []
},
{
"id": "NCT02733159_inc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02733159_inc_T3",
"arg2_id": "NCT02733159_inc_T4",
"normalized": []
},
{
"id": "NCT02733159_inc_R3",
"type": "Has_index",
"arg1_id": "NCT02733159_inc_T4",
"arg2_id": "NCT02733159_inc_T5",
"normalized": []
},
{
"id": "NCT02733159_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02733159_inc_T7",
"arg2_id": "NCT02733159_inc_T8",
"normalized": []
},
{
"id": "NCT02733159_inc_R5",
"type": "AND",
"arg1_id": "NCT02733159_inc_T12",
"arg2_id": "NCT02733159_inc_T10",
"normalized": []
},
{
"id": "NCT02733159_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02733159_inc_T10",
"arg2_id": "NCT02733159_inc_T11",
"normalized": []
},
{
"id": "NCT02733159_inc_R7",
"type": "Has_index",
"arg1_id": "NCT02733159_inc_T15",
"arg2_id": "NCT02733159_inc_T16",
"normalized": []
},
{
"id": "NCT02733159_inc_R8",
"type": "Has_temporal",
"arg1_id": "NCT02733159_inc_T14",
"arg2_id": "NCT02733159_inc_T15",
"normalized": []
},
{
"id": "NCT02733159_inc_R9",
"type": "Has_value",
"arg1_id": "NCT02733159_inc_T18",
"arg2_id": "NCT02733159_inc_T19",
"normalized": []
},
{
"id": "NCT02733159_inc_R10",
"type": "Has_value",
"arg1_id": "NCT02733159_inc_T20",
"arg2_id": "NCT02733159_inc_T21",
"normalized": []
},
{
"id": "NCT02733159_inc_R11",
"type": "Has_value",
"arg1_id": "NCT02733159_inc_T22",
"arg2_id": "NCT02733159_inc_T23",
"normalized": []
},
{
"id": "NCT02733159_inc_R12",
"type": "Has_value",
"arg1_id": "NCT02733159_inc_T26",
"arg2_id": "NCT02733159_inc_T27",
"normalized": []
},
{
"id": "NCT02733159_inc_R13",
"type": "Has_value",
"arg1_id": "NCT02733159_inc_T28",
"arg2_id": "NCT02733159_inc_T29",
"normalized": []
},
{
"id": "NCT02733159_inc_R14",
"type": "Has_value",
"arg1_id": "NCT02733159_inc_T30",
"arg2_id": "NCT02733159_inc_T31",
"normalized": []
},
{
"id": "NCT02733159_inc_R15",
"type": "Has_value",
"arg1_id": "NCT02733159_inc_T33",
"arg2_id": "NCT02733159_inc_T34",
"normalized": []
},
{
"id": "NCT02733159_inc_R16",
"type": "Has_temporal",
"arg1_id": "NCT02733159_inc_T30",
"arg2_id": "NCT02733159_inc_T32",
"normalized": []
},
{
"id": "NCT02733159_inc_R17",
"type": "Has_temporal",
"arg1_id": "NCT02733159_inc_T33",
"arg2_id": "NCT02733159_inc_T32",
"normalized": []
},
{
"id": "NCT02733159_inc_R18",
"type": "Has_value",
"arg1_id": "NCT02733159_inc_T35",
"arg2_id": "NCT02733159_inc_T36",
"normalized": []
},
{
"id": "NCT02733159_inc_R19",
"type": "Subsumes",
"arg1_id": "NCT02733159_inc_T36",
"arg2_id": "NCT02733159_inc_T37",
"normalized": []
}
] |
NCT02734173_exc
|
NCT02734173
|
[
{
"id": "NCT02734173_exc_text",
"type": "exclusion",
"text": [
"<18 years old\nEvidence of decompensated liver disease\nHOMA IR< 2.0\nHIV seropositivity\nChronic HBV/HIV infection\nUse of immune suppressing medications\nActive malignancy\n"
],
"offsets": [
[
0,
168
]
]
}
] |
[
{
"id": "NCT02734173_exc_T1",
"type": "Person",
"text": [
"old"
],
"offsets": [
[
10,
13
]
],
"normalized": []
},
{
"id": "NCT02734173_exc_T2",
"type": "Value",
"text": [
"<18 years"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "NCT02734173_exc_T3",
"type": "Qualifier",
"text": [
"decompensated"
],
"offsets": [
[
26,
39
]
],
"normalized": []
},
{
"id": "NCT02734173_exc_T4",
"type": "Condition",
"text": [
"liver disease"
],
"offsets": [
[
40,
53
]
],
"normalized": []
},
{
"id": "NCT02734173_exc_T5",
"type": "Measurement",
"text": [
"HOMA IR"
],
"offsets": [
[
54,
61
]
],
"normalized": []
},
{
"id": "NCT02734173_exc_T6",
"type": "Value",
"text": [
"< 2.0"
],
"offsets": [
[
61,
66
]
],
"normalized": []
},
{
"id": "NCT02734173_exc_T7",
"type": "Measurement",
"text": [
"HIV"
],
"offsets": [
[
67,
70
]
],
"normalized": []
},
{
"id": "NCT02734173_exc_T8",
"type": "Value",
"text": [
"seropositivity"
],
"offsets": [
[
71,
85
]
],
"normalized": []
},
{
"id": "NCT02734173_exc_T9",
"type": "Condition",
"text": [
"ction\nUse",
"nic HBV/HIV"
],
"offsets": [
[
106,
115
],
[
90,
101
]
],
"normalized": []
},
{
"id": "NCT02734173_exc_T10",
"type": "Condition",
"text": [
"infection\nUse",
"nic HBV"
],
"offsets": [
[
102,
115
],
[
90,
97
]
],
"normalized": []
},
{
"id": "NCT02734173_exc_T11",
"type": "Drug",
"text": [
"immune suppressing medications"
],
"offsets": [
[
119,
149
]
],
"normalized": []
},
{
"id": "NCT02734173_exc_T12",
"type": "Condition",
"text": [
"malignancy"
],
"offsets": [
[
157,
167
]
],
"normalized": []
},
{
"id": "NCT02734173_exc_T13",
"type": "Qualifier",
"text": [
"Active"
],
"offsets": [
[
150,
156
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02734173_exc_R1",
"type": "Has_value",
"arg1_id": "NCT02734173_exc_T1",
"arg2_id": "NCT02734173_exc_T2",
"normalized": []
},
{
"id": "NCT02734173_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02734173_exc_T4",
"arg2_id": "NCT02734173_exc_T3",
"normalized": []
},
{
"id": "NCT02734173_exc_R3",
"type": "Has_value",
"arg1_id": "NCT02734173_exc_T5",
"arg2_id": "NCT02734173_exc_T6",
"normalized": []
},
{
"id": "NCT02734173_exc_R4",
"type": "Has_value",
"arg1_id": "NCT02734173_exc_T7",
"arg2_id": "NCT02734173_exc_T8",
"normalized": []
},
{
"id": "NCT02734173_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02734173_exc_T12",
"arg2_id": "NCT02734173_exc_T13",
"normalized": []
}
] |
NCT02734173_inc
|
NCT02734173
|
[
{
"id": "NCT02734173_inc_text",
"type": "inclusion",
"text": [
"HCV RNA evidence of HCV infection\nDocumented history of chronic HCV RNA infection with Genotype 1\nAble to provide informed consent\nAvailable for ongoing follow-up if required\n"
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "NCT02734173_inc_T1",
"type": "Measurement",
"text": [
"HCV RNA"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "NCT02734173_inc_T2",
"type": "Condition",
"text": [
"HCV infection"
],
"offsets": [
[
20,
33
]
],
"normalized": []
},
{
"id": "NCT02734173_inc_T3",
"type": "Condition",
"text": [
"hronic HCV",
"nfection"
],
"offsets": [
[
57,
67
],
[
73,
81
]
],
"normalized": []
},
{
"id": "NCT02734173_inc_T4",
"type": "Qualifier",
"text": [
"Genotype 1"
],
"offsets": [
[
87,
97
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02734173_inc_R1",
"type": "AND",
"arg1_id": "NCT02734173_inc_T1",
"arg2_id": "NCT02734173_inc_T2",
"normalized": []
},
{
"id": "NCT02734173_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02734173_inc_T3",
"arg2_id": "NCT02734173_inc_T4",
"normalized": []
}
] |
NCT02735577_exc
|
NCT02735577
|
[
{
"id": "NCT02735577_exc_text",
"type": "exclusion",
"text": [
"Risk of severe alcohol withdrawal (e.g. history of seizures or delirium tremens)\nCurrent Moderate or Severe Substance Use Disorder, other than Alcohol, Nicotine or Caffeine Use Disorders\nLifetime history of Bipolar Disorder, Schizophrenia or Schizoaffective Disorder\nAny current psychiatric disorder, other than Alcohol Use Disorder, that, in the judgment of the investigator, will require treatment that will interfere with study participation.\nCurrent severe depression (HAM-D >24) or anxiety (HAM-A >24)\nSignificant suicide or violence risk\nCurrently taking any psychotropic medications\nLegally mandated to participate in treatment\nHistory of prior treatment with disulfiram\nSufficiently socially unstable as to preclude participation (e.g. homeless)\nContraindications to disulfiram treatment (liver disease, kidney disease, cardiac disease, seizure disorder, hypothyroidism, diabetes mellitus, pregnancy or lactation, allergy to disulfiram or thiuran derivatives)\nNeurological or medical conditions that would interfere with MRI scanning (e.g. history of stroke, seizure, brain tumor, brain infection, traumatic brain injury, multiple sclerosis, dementia, metal device in body, pregnancy, claustrophobia, color blindness, severe hearing impairment, weight>300 lbs., wheelchair-bound)\nCurrently taking medications containing alcohol, metronidazole, isoniazid, paraldehyde, phenytoin, warfarin, or theophylline.\nSignificant alcohol withdrawal (CIWA>8) at screening, after confirming a blood alcohol level of zero.\n"
],
"offsets": [
[
0,
1516
]
]
}
] |
[
{
"id": "NCT02735577_exc_T1",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
8,
14
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T2",
"type": "Condition",
"text": [
"alcohol withdrawal"
],
"offsets": [
[
15,
33
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T3",
"type": "Mood",
"text": [
"Risk of"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T4",
"type": "Condition",
"text": [
"seizures"
],
"offsets": [
[
51,
59
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T5",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
40,
47
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T6",
"type": "Condition",
"text": [
"delirium tremens"
],
"offsets": [
[
63,
79
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T7",
"type": "Scope",
"text": [
"seizures or delirium tremens"
],
"offsets": [
[
51,
79
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T8",
"type": "Condition",
"text": [
"Substance Use Disorder"
],
"offsets": [
[
108,
130
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T9",
"type": "Qualifier",
"text": [
"Moderate"
],
"offsets": [
[
89,
97
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T10",
"type": "Qualifier",
"text": [
"Severe"
],
"offsets": [
[
101,
107
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T11",
"type": "Temporal",
"text": [
"Current"
],
"offsets": [
[
81,
88
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T12",
"type": "Scope",
"text": [
"Moderate or Severe"
],
"offsets": [
[
89,
107
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T13",
"type": "Negation",
"text": [
"other than"
],
"offsets": [
[
132,
142
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T14",
"type": "Condition",
"text": [
"lcohol,",
"se Disorders"
],
"offsets": [
[
144,
151
],
[
174,
186
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T15",
"type": "Condition",
"text": [
"icotine",
"se Disorders"
],
"offsets": [
[
153,
160
],
[
174,
186
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T16",
"type": "Condition",
"text": [
"Caffeine Use Disorders"
],
"offsets": [
[
164,
186
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T17",
"type": "Scope",
"text": [
"Alcohol, Nicotine or Caffeine Use Disorders"
],
"offsets": [
[
143,
186
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T18",
"type": "Condition",
"text": [
"Bipolar Disorder"
],
"offsets": [
[
207,
223
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T19",
"type": "Observation",
"text": [
"Lifetime history"
],
"offsets": [
[
187,
203
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T20",
"type": "Condition",
"text": [
"Schizophrenia"
],
"offsets": [
[
225,
238
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T21",
"type": "Condition",
"text": [
"Schizoaffective Disorder"
],
"offsets": [
[
242,
266
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T22",
"type": "Scope",
"text": [
"Bipolar Disorder, Schizophrenia or Schizoaffective Disorder"
],
"offsets": [
[
207,
266
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T23",
"type": "Condition",
"text": [
"psychiatric disorder"
],
"offsets": [
[
279,
299
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T24",
"type": "Temporal",
"text": [
"current"
],
"offsets": [
[
271,
278
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T25",
"type": "Condition",
"text": [
"Alcohol Use Disorder"
],
"offsets": [
[
312,
332
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T27",
"type": "Negation",
"text": [
"other than"
],
"offsets": [
[
301,
311
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T28",
"type": "Temporal",
"text": [
"Current"
],
"offsets": [
[
446,
453
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T29",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
454,
460
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T30",
"type": "Condition",
"text": [
"depression"
],
"offsets": [
[
461,
471
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T31",
"type": "Measurement",
"text": [
"HAM-D"
],
"offsets": [
[
473,
478
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T32",
"type": "Value",
"text": [
">24"
],
"offsets": [
[
479,
482
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T33",
"type": "Condition",
"text": [
"anxiety"
],
"offsets": [
[
487,
494
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T34",
"type": "Measurement",
"text": [
"HAM-A"
],
"offsets": [
[
496,
501
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T35",
"type": "Value",
"text": [
">24"
],
"offsets": [
[
502,
505
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T36",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
454,
460
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T37",
"type": "Scope",
"text": [
"severe depression (HAM-D >24) or anxiety (HAM-A >24)"
],
"offsets": [
[
454,
506
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T38",
"type": "Condition",
"text": [
"de or v",
"Curr"
],
"offsets": [
[
524,
531
],
[
544,
548
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T39",
"type": "Condition",
"text": [
"violence risk"
],
"offsets": [
[
530,
543
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T40",
"type": "Qualifier",
"text": [
"Significant"
],
"offsets": [
[
507,
518
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T41",
"type": "Scope",
"text": [
"suicide or violence risk"
],
"offsets": [
[
519,
543
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T42",
"type": "Drug",
"text": [
"psychotropic medications"
],
"offsets": [
[
565,
589
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T43",
"type": "Temporal",
"text": [
"Currently"
],
"offsets": [
[
544,
553
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T45",
"type": "Drug",
"text": [
"disulfiram"
],
"offsets": [
[
667,
677
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T46",
"type": "Observation",
"text": [
"History of prior treatment"
],
"offsets": [
[
635,
661
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T47",
"type": "Condition",
"text": [
"socially unstable"
],
"offsets": [
[
691,
708
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T48",
"type": "Qualifier",
"text": [
"Sufficiently"
],
"offsets": [
[
678,
690
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T49",
"type": "Condition",
"text": [
"Contraindications"
],
"offsets": [
[
754,
771
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T50",
"type": "Drug",
"text": [
"disulfiram"
],
"offsets": [
[
775,
785
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T51",
"type": "Condition",
"text": [
"liver disease"
],
"offsets": [
[
797,
810
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T52",
"type": "Condition",
"text": [
"kidney disease"
],
"offsets": [
[
812,
826
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T53",
"type": "Condition",
"text": [
"cardiac disease"
],
"offsets": [
[
828,
843
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T54",
"type": "Condition",
"text": [
"seizure disorder"
],
"offsets": [
[
845,
861
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T55",
"type": "Condition",
"text": [
"hypothyroidism"
],
"offsets": [
[
863,
877
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T56",
"type": "Condition",
"text": [
"diabetes mellitus"
],
"offsets": [
[
879,
896
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T57",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
898,
907
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T58",
"type": "Condition",
"text": [
"lactation"
],
"offsets": [
[
911,
920
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T59",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
922,
929
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T60",
"type": "Drug",
"text": [
"disulfiram"
],
"offsets": [
[
933,
943
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T61",
"type": "Drug",
"text": [
"thiuran derivatives"
],
"offsets": [
[
947,
966
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T62",
"type": "Scope",
"text": [
"disulfiram or thiuran derivatives"
],
"offsets": [
[
933,
966
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T63",
"type": "Scope",
"text": [
"liver disease, kidney disease, cardiac disease, seizure disorder, hypothyroidism, diabetes mellitus, pregnancy or lactation, allergy to disulfiram or thiuran derivatives"
],
"offsets": [
[
797,
966
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T64",
"type": "Scope",
"text": [
"Contraindications to disulfiram"
],
"offsets": [
[
754,
785
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T65",
"type": "Condition",
"text": [
"medical conditions"
],
"offsets": [
[
984,
1002
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T66",
"type": "Condition",
"text": [
"that would",
"l or medical"
],
"offsets": [
[
1003,
1013
],
[
979,
991
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T67",
"type": "Condition",
"text": [
"interfere"
],
"offsets": [
[
1014,
1023
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T68",
"type": "Procedure",
"text": [
"MRI scanning"
],
"offsets": [
[
1029,
1041
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T69",
"type": "Scope",
"text": [
"Neurological or medical conditions"
],
"offsets": [
[
968,
1002
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T70",
"type": "Condition",
"text": [
"stroke"
],
"offsets": [
[
1059,
1065
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T71",
"type": "Condition",
"text": [
"seizure"
],
"offsets": [
[
1067,
1074
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T72",
"type": "Condition",
"text": [
"brain tumor"
],
"offsets": [
[
1076,
1087
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T73",
"type": "Condition",
"text": [
"brain infection"
],
"offsets": [
[
1089,
1104
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T74",
"type": "Condition",
"text": [
"traumatic brain injury"
],
"offsets": [
[
1106,
1128
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T75",
"type": "Condition",
"text": [
"multiple sclerosis"
],
"offsets": [
[
1130,
1148
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T76",
"type": "Condition",
"text": [
"dementia"
],
"offsets": [
[
1150,
1158
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T77",
"type": "Device",
"text": [
"metal device in body"
],
"offsets": [
[
1160,
1180
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T78",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
1182,
1191
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T79",
"type": "Condition",
"text": [
"claustrophobia"
],
"offsets": [
[
1193,
1207
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T80",
"type": "Condition",
"text": [
"color blindness"
],
"offsets": [
[
1209,
1224
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T81",
"type": "Condition",
"text": [
"hearing impairment"
],
"offsets": [
[
1233,
1251
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T82",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
1226,
1232
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T83",
"type": "Measurement",
"text": [
"weight"
],
"offsets": [
[
1253,
1259
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T84",
"type": "Value",
"text": [
">300 lbs."
],
"offsets": [
[
1259,
1268
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T85",
"type": "Condition",
"text": [
"wheelchair-bound"
],
"offsets": [
[
1270,
1286
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T86",
"type": "Drug",
"text": [
"alcohol"
],
"offsets": [
[
1328,
1335
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T87",
"type": "Drug",
"text": [
"metronidazole"
],
"offsets": [
[
1337,
1350
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T88",
"type": "Drug",
"text": [
"isoniazid"
],
"offsets": [
[
1352,
1361
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T89",
"type": "Drug",
"text": [
"paraldehyde"
],
"offsets": [
[
1363,
1374
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T90",
"type": "Drug",
"text": [
"phenytoin"
],
"offsets": [
[
1376,
1385
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T91",
"type": "Drug",
"text": [
"warfarin"
],
"offsets": [
[
1387,
1395
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T92",
"type": "Drug",
"text": [
"theophylline"
],
"offsets": [
[
1400,
1412
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T93",
"type": "Temporal",
"text": [
"Currently"
],
"offsets": [
[
1288,
1297
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T94",
"type": "Scope",
"text": [
"alcohol, metronidazole, isoniazid, paraldehyde, phenytoin, warfarin, or theophylline"
],
"offsets": [
[
1328,
1412
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T95",
"type": "Qualifier",
"text": [
"Significant"
],
"offsets": [
[
1414,
1425
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T96",
"type": "Condition",
"text": [
"alcohol withdrawal"
],
"offsets": [
[
1426,
1444
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T97",
"type": "Measurement",
"text": [
"CIWA"
],
"offsets": [
[
1446,
1450
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T98",
"type": "Value",
"text": [
">8"
],
"offsets": [
[
1450,
1452
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T99",
"type": "Temporal",
"text": [
"at screening"
],
"offsets": [
[
1454,
1466
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T100",
"type": "Measurement",
"text": [
"blood alcohol level"
],
"offsets": [
[
1487,
1506
]
],
"normalized": []
},
{
"id": "NCT02735577_exc_T101",
"type": "Value",
"text": [
"zero"
],
"offsets": [
[
1510,
1514
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02735577_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02735577_exc_T2",
"arg2_id": "NCT02735577_exc_T1",
"normalized": []
},
{
"id": "NCT02735577_exc_R2",
"type": "Has_mood",
"arg1_id": "NCT02735577_exc_T2",
"arg2_id": "NCT02735577_exc_T3",
"normalized": []
},
{
"id": "NCT02735577_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02735577_exc_T7",
"arg2_id": "NCT02735577_exc_T5",
"normalized": []
},
{
"id": "NCT02735577_exc_R4",
"type": "Has_scope",
"arg1_id": "NCT02735577_exc_T8",
"arg2_id": "NCT02735577_exc_T12",
"normalized": []
},
{
"id": "NCT02735577_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02735577_exc_T8",
"arg2_id": "NCT02735577_exc_T11",
"normalized": []
},
{
"id": "NCT02735577_exc_R6",
"type": "Has_negation",
"arg1_id": "NCT02735577_exc_T17",
"arg2_id": "NCT02735577_exc_T13",
"normalized": []
},
{
"id": "NCT02735577_exc_R7",
"type": "Has_scope",
"arg1_id": "NCT02735577_exc_T8",
"arg2_id": "NCT02735577_exc_T17",
"normalized": []
},
{
"id": "NCT02735577_exc_R8",
"type": "Has_temporal",
"arg1_id": "NCT02735577_exc_T22",
"arg2_id": "NCT02735577_exc_T19",
"normalized": []
},
{
"id": "NCT02735577_exc_R9",
"type": "Has_negation",
"arg1_id": "NCT02735577_exc_T25",
"arg2_id": "NCT02735577_exc_T27",
"normalized": []
},
{
"id": "NCT02735577_exc_R10",
"type": "AND",
"arg1_id": "NCT02735577_exc_T23",
"arg2_id": "NCT02735577_exc_T25",
"normalized": []
},
{
"id": "NCT02735577_exc_R11",
"type": "Has_temporal",
"arg1_id": "NCT02735577_exc_T23",
"arg2_id": "NCT02735577_exc_T24",
"normalized": []
},
{
"id": "NCT02735577_exc_R12",
"type": "Has_value",
"arg1_id": "NCT02735577_exc_T31",
"arg2_id": "NCT02735577_exc_T32",
"normalized": []
},
{
"id": "NCT02735577_exc_R13",
"type": "Subsumes",
"arg1_id": "NCT02735577_exc_T29",
"arg2_id": "NCT02735577_exc_T31",
"normalized": []
},
{
"id": "NCT02735577_exc_R14",
"type": "Has_qualifier",
"arg1_id": "NCT02735577_exc_T30",
"arg2_id": "NCT02735577_exc_T29",
"normalized": []
},
{
"id": "NCT02735577_exc_R15",
"type": "Subsumes",
"arg1_id": "NCT02735577_exc_T36",
"arg2_id": "NCT02735577_exc_T34",
"normalized": []
},
{
"id": "NCT02735577_exc_R16",
"type": "Has_value",
"arg1_id": "NCT02735577_exc_T34",
"arg2_id": "NCT02735577_exc_T35",
"normalized": []
},
{
"id": "NCT02735577_exc_R17",
"type": "Has_temporal",
"arg1_id": "NCT02735577_exc_T37",
"arg2_id": "NCT02735577_exc_T28",
"normalized": []
},
{
"id": "NCT02735577_exc_R18",
"type": "Has_qualifier",
"arg1_id": "NCT02735577_exc_T41",
"arg2_id": "NCT02735577_exc_T40",
"normalized": []
},
{
"id": "NCT02735577_exc_R19",
"type": "Has_temporal",
"arg1_id": "NCT02735577_exc_T42",
"arg2_id": "NCT02735577_exc_T43",
"normalized": []
},
{
"id": "NCT02735577_exc_R20",
"type": "Has_temporal",
"arg1_id": "NCT02735577_exc_T45",
"arg2_id": "NCT02735577_exc_T46",
"normalized": []
},
{
"id": "NCT02735577_exc_R21",
"type": "Has_qualifier",
"arg1_id": "NCT02735577_exc_T47",
"arg2_id": "NCT02735577_exc_T48",
"normalized": []
},
{
"id": "NCT02735577_exc_R22",
"type": "Has_scope",
"arg1_id": "NCT02735577_exc_T59",
"arg2_id": "NCT02735577_exc_T62",
"normalized": []
},
{
"id": "NCT02735577_exc_R23",
"type": "AND",
"arg1_id": "NCT02735577_exc_T49",
"arg2_id": "NCT02735577_exc_T50",
"normalized": []
},
{
"id": "NCT02735577_exc_R24",
"type": "Subsumes",
"arg1_id": "NCT02735577_exc_T64",
"arg2_id": "NCT02735577_exc_T63",
"normalized": []
},
{
"id": "NCT02735577_exc_R25",
"type": "AND",
"arg1_id": "NCT02735577_exc_T69",
"arg2_id": "NCT02735577_exc_T67",
"normalized": []
},
{
"id": "NCT02735577_exc_R26",
"type": "AND",
"arg1_id": "NCT02735577_exc_T67",
"arg2_id": "NCT02735577_exc_T68",
"normalized": []
},
{
"id": "NCT02735577_exc_R27",
"type": "Has_qualifier",
"arg1_id": "NCT02735577_exc_T81",
"arg2_id": "NCT02735577_exc_T82",
"normalized": []
},
{
"id": "NCT02735577_exc_R28",
"type": "Has_value",
"arg1_id": "NCT02735577_exc_T83",
"arg2_id": "NCT02735577_exc_T84",
"normalized": []
},
{
"id": "NCT02735577_exc_R29",
"type": "Has_temporal",
"arg1_id": "NCT02735577_exc_T94",
"arg2_id": "NCT02735577_exc_T93",
"normalized": []
},
{
"id": "NCT02735577_exc_R30",
"type": "Has_value",
"arg1_id": "NCT02735577_exc_T97",
"arg2_id": "NCT02735577_exc_T98",
"normalized": []
},
{
"id": "NCT02735577_exc_R31",
"type": "Subsumes",
"arg1_id": "NCT02735577_exc_T95",
"arg2_id": "NCT02735577_exc_T97",
"normalized": []
},
{
"id": "NCT02735577_exc_R32",
"type": "Has_qualifier",
"arg1_id": "NCT02735577_exc_T96",
"arg2_id": "NCT02735577_exc_T95",
"normalized": []
},
{
"id": "NCT02735577_exc_R33",
"type": "Has_value",
"arg1_id": "NCT02735577_exc_T100",
"arg2_id": "NCT02735577_exc_T101",
"normalized": []
},
{
"id": "NCT02735577_exc_R34",
"type": "Has_temporal",
"arg1_id": "NCT02735577_exc_T96",
"arg2_id": "NCT02735577_exc_T99",
"normalized": []
}
] |
NCT02735577_inc
|
NCT02735577
|
[
{
"id": "NCT02735577_inc_text",
"type": "inclusion",
"text": [
"Between the ages of 21-60\nRight-handed\nCapable of giving informed consent and complying with study procedures\nReports drinking a minimum of 5 standard drinks for men or 4 standard drinks for women on at least 4 days per week on average over the past 28 days\nMeets DSM-V criteria for current Alcohol Use Disorder\nSeeking treatment for Alcohol Use Disorder\nAgree to not seek additional treatment, apart from Alcoholics Anonymous\nWilling to attempt to abstain from alcohol completely for the duration of the study\nWilling to be hospitalized on a research unit for 24 hours, longer if detoxification is needed.\n"
],
"offsets": [
[
0,
607
]
]
}
] |
[
{
"id": "NCT02735577_inc_T1",
"type": "Person",
"text": [
"ages"
],
"offsets": [
[
12,
16
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T2",
"type": "Value",
"text": [
"Between",
"21-60"
],
"offsets": [
[
0,
7
],
[
20,
25
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T3",
"type": "Condition",
"text": [
"Right-handed"
],
"offsets": [
[
26,
38
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T5",
"type": "Value",
"text": [
"imum of 5 standard drinks fo",
"at least 4 days per week on"
],
"offsets": [
[
132,
160
],
[
200,
227
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T6",
"type": "Measurement",
"text": [
"drinking"
],
"offsets": [
[
118,
126
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T7",
"type": "Person",
"text": [
"men"
],
"offsets": [
[
162,
165
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T8",
"type": "Value",
"text": [
"tandard drinks fo",
"at least 4 days per week on"
],
"offsets": [
[
172,
189
],
[
200,
227
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T9",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
191,
196
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T11",
"type": "Temporal",
"text": [
"over the past 28 days"
],
"offsets": [
[
236,
257
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T10",
"type": "Scope",
"text": [
"minimum of 5 standard drinks for men or 4 standard drinks for women on at least 4 days per week"
],
"offsets": [
[
129,
224
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T12",
"type": "Measurement",
"text": [
"DSM-V criteria"
],
"offsets": [
[
264,
278
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T13",
"type": "Value",
"text": [
"Meets"
],
"offsets": [
[
258,
263
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T14",
"type": "Condition",
"text": [
"Alcohol Use Disorder"
],
"offsets": [
[
291,
311
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T15",
"type": "Condition",
"text": [
"Alcohol Use Disorder"
],
"offsets": [
[
334,
354
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T16",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
320,
329
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T17",
"type": "Mood",
"text": [
"Seeking"
],
"offsets": [
[
312,
319
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T19",
"type": "Mood",
"text": [
"Willing"
],
"offsets": [
[
427,
434
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T20",
"type": "Condition",
"text": [
"abstain from alcohol"
],
"offsets": [
[
449,
469
]
],
"normalized": []
},
{
"id": "NCT02735577_inc_T21",
"type": "Qualifier",
"text": [
"completely"
],
"offsets": [
[
470,
480
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02735577_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02735577_inc_T1",
"arg2_id": "NCT02735577_inc_T2",
"normalized": []
},
{
"id": "NCT02735577_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02735577_inc_T7",
"arg2_id": "NCT02735577_inc_T5",
"normalized": []
},
{
"id": "NCT02735577_inc_R3",
"type": "Has_value",
"arg1_id": "NCT02735577_inc_T9",
"arg2_id": "NCT02735577_inc_T8",
"normalized": []
},
{
"id": "NCT02735577_inc_R4",
"type": "Has_scope",
"arg1_id": "NCT02735577_inc_T6",
"arg2_id": "NCT02735577_inc_T10",
"normalized": []
},
{
"id": "NCT02735577_inc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02735577_inc_T6",
"arg2_id": "NCT02735577_inc_T11",
"normalized": []
},
{
"id": "NCT02735577_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02735577_inc_T12",
"arg2_id": "NCT02735577_inc_T13",
"normalized": []
},
{
"id": "NCT02735577_inc_R7",
"type": "AND",
"arg1_id": "NCT02735577_inc_T14",
"arg2_id": "NCT02735577_inc_T12",
"normalized": []
},
{
"id": "NCT02735577_inc_R8",
"type": "Has_mood",
"arg1_id": "NCT02735577_inc_T16",
"arg2_id": "NCT02735577_inc_T17",
"normalized": []
},
{
"id": "NCT02735577_inc_R9",
"type": "AND",
"arg1_id": "NCT02735577_inc_T16",
"arg2_id": "NCT02735577_inc_T15",
"normalized": []
},
{
"id": "NCT02735577_inc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT02735577_inc_T20",
"arg2_id": "NCT02735577_inc_T21",
"normalized": []
},
{
"id": "NCT02735577_inc_R11",
"type": "Has_mood",
"arg1_id": "NCT02735577_inc_T20",
"arg2_id": "NCT02735577_inc_T19",
"normalized": []
}
] |
NCT02735902_exc
|
NCT02735902
|
[
{
"id": "NCT02735902_exc_text",
"type": "exclusion",
"text": [
"The patient is participating in another study\nThe patient is in an exclusion period determined by a previous study\nThe patient or his/her representative refuses to sign the consent\nIt is impossible to correctly inform the patient or his/her representative\nThe patient is pregnant or breastfeeding\nThe patient has a contraindication (or an incompatible drug association) for a treatment used in this study\nThe patient had a coronary stent for less than 12 months\nThe patient does not require treatment with aspirin or any other antiplatelet agent\nThe patient has a history of aspirin allergy\nHigh bleeding risk; such as platelets <50,000 / mm3 during screening, Hb <8.5 g / dL, history of intracranial hemorrhage or subdural hematoma, major surgery, parenchymal organ biopsy or severe trauma within 30 days before inclusion, active gastrointestinal ulcer in the last 3 months;\nHistory of Stroke in the last 3 months;\nModerate or severe liver affection associated with coagulopathy\nActive infectious endocarditis\nActive tumor treated at the time of inclusion associated with expected survival less than one year\n"
],
"offsets": [
[
0,
1110
]
]
}
] |
[
{
"id": "NCT02735902_exc_T6",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
315,
331
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T8",
"type": "Device",
"text": [
"coronary stent"
],
"offsets": [
[
423,
437
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T9",
"type": "Temporal",
"text": [
"less than 12 months"
],
"offsets": [
[
442,
461
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T10",
"type": "Drug",
"text": [
"aspirin"
],
"offsets": [
[
575,
582
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T11",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
583,
590
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T12",
"type": "Observation",
"text": [
"bleeding risk"
],
"offsets": [
[
596,
609
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T13",
"type": "Qualifier",
"text": [
"High"
],
"offsets": [
[
591,
595
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T14",
"type": "Measurement",
"text": [
"platelets"
],
"offsets": [
[
619,
628
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T15",
"type": "Value",
"text": [
"<50,000 / mm3"
],
"offsets": [
[
629,
642
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T16",
"type": "Measurement",
"text": [
"Hb"
],
"offsets": [
[
661,
663
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T17",
"type": "Value",
"text": [
"<8.5 g / dL"
],
"offsets": [
[
664,
675
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T18",
"type": "Condition",
"text": [
"intracranial hemorrhage"
],
"offsets": [
[
688,
711
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T19",
"type": "Condition",
"text": [
"subdural hematoma"
],
"offsets": [
[
715,
732
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T20",
"type": "Procedure",
"text": [
"major surgery,"
],
"offsets": [
[
734,
748
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T21",
"type": "Procedure",
"text": [
"parenchymal organ biopsy"
],
"offsets": [
[
749,
773
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T22",
"type": "Condition",
"text": [
"trauma"
],
"offsets": [
[
784,
790
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T23",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
777,
783
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T24",
"type": "Temporal",
"text": [
"within 30 days"
],
"offsets": [
[
791,
805
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T25",
"type": "Qualifier",
"text": [
"active"
],
"offsets": [
[
824,
830
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T26",
"type": "Condition",
"text": [
"gastrointestinal ulcer"
],
"offsets": [
[
831,
853
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T27",
"type": "Temporal",
"text": [
"last 3 months"
],
"offsets": [
[
861,
874
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T28",
"type": "Scope",
"text": [
"intracranial hemorrhage or subdural hematoma, major surgery, parenchymal organ biopsy or severe trauma"
],
"offsets": [
[
688,
790
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T30",
"type": "Scope",
"text": [
"platelets <50,000 / mm3 during screening, Hb <8.5 g / dL, history of intracranial hemorrhage or subdural hematoma, major surgery, parenchymal organ biopsy or severe trauma within 30 days before inclusion, active gastrointestinal ulcer in the last 3 months"
],
"offsets": [
[
619,
874
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T29",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
479,
482
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T31",
"type": "Mood",
"text": [
"require"
],
"offsets": [
[
483,
490
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T32",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
491,
500
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T33",
"type": "Drug",
"text": [
"aspirin"
],
"offsets": [
[
506,
513
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T34",
"type": "Drug",
"text": [
"antiplatelet agent"
],
"offsets": [
[
527,
545
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T35",
"type": "Qualifier",
"text": [
"other"
],
"offsets": [
[
521,
526
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T36",
"type": "Scope",
"text": [
"aspirin or any other antiplatelet agent"
],
"offsets": [
[
506,
545
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T37",
"type": "Observation",
"text": [
"history of"
],
"offsets": [
[
564,
574
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T38",
"type": "Observation",
"text": [
"History of"
],
"offsets": [
[
876,
886
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T39",
"type": "Condition",
"text": [
"Stroke"
],
"offsets": [
[
887,
893
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T40",
"type": "Temporal",
"text": [
"in the last 3 months"
],
"offsets": [
[
894,
914
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T41",
"type": "Qualifier",
"text": [
"Moderate"
],
"offsets": [
[
916,
924
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T42",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
928,
934
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T43",
"type": "Condition",
"text": [
"liver affection"
],
"offsets": [
[
935,
950
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T44",
"type": "Qualifier",
"text": [
"associated with coagulopathy"
],
"offsets": [
[
951,
979
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T45",
"type": "Condition",
"text": [
"coagulopathy"
],
"offsets": [
[
967,
979
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T46",
"type": "Scope",
"text": [
"Moderate or severe"
],
"offsets": [
[
916,
934
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T47",
"type": "Qualifier",
"text": [
"Active"
],
"offsets": [
[
980,
986
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T48",
"type": "Condition",
"text": [
"infectious endocarditis"
],
"offsets": [
[
987,
1010
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T49",
"type": "Temporal",
"text": [
"Active"
],
"offsets": [
[
980,
986
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T50",
"type": "Qualifier",
"text": [
"Active"
],
"offsets": [
[
1011,
1017
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T51",
"type": "Temporal",
"text": [
"Active"
],
"offsets": [
[
1011,
1017
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T52",
"type": "Condition",
"text": [
"tumor"
],
"offsets": [
[
1018,
1023
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T53",
"type": "Procedure",
"text": [
"treated"
],
"offsets": [
[
1024,
1031
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T54",
"type": "Temporal",
"text": [
"at the time of inclusion"
],
"offsets": [
[
1032,
1056
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T55",
"type": "Measurement",
"text": [
"expected survival"
],
"offsets": [
[
1073,
1090
]
],
"normalized": []
},
{
"id": "NCT02735902_exc_T56",
"type": "Value",
"text": [
"less than one year"
],
"offsets": [
[
1091,
1109
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02735902_exc_R1",
"type": "Has_temporal",
"arg1_id": "NCT02735902_exc_T8",
"arg2_id": "NCT02735902_exc_T9",
"normalized": []
},
{
"id": "NCT02735902_exc_R2",
"type": "AND",
"arg1_id": "NCT02735902_exc_T11",
"arg2_id": "NCT02735902_exc_T10",
"normalized": []
},
{
"id": "NCT02735902_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02735902_exc_T12",
"arg2_id": "NCT02735902_exc_T13",
"normalized": []
},
{
"id": "NCT02735902_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02735902_exc_T22",
"arg2_id": "NCT02735902_exc_T23",
"normalized": []
},
{
"id": "NCT02735902_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02735902_exc_T26",
"arg2_id": "NCT02735902_exc_T25",
"normalized": []
},
{
"id": "NCT02735902_exc_R6",
"type": "Has_value",
"arg1_id": "NCT02735902_exc_T14",
"arg2_id": "NCT02735902_exc_T15",
"normalized": []
},
{
"id": "NCT02735902_exc_R7",
"type": "Has_value",
"arg1_id": "NCT02735902_exc_T16",
"arg2_id": "NCT02735902_exc_T17",
"normalized": []
},
{
"id": "NCT02735902_exc_R8",
"type": "Has_temporal",
"arg1_id": "NCT02735902_exc_T28",
"arg2_id": "NCT02735902_exc_T24",
"normalized": []
},
{
"id": "NCT02735902_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT02735902_exc_T26",
"arg2_id": "NCT02735902_exc_T27",
"normalized": []
},
{
"id": "NCT02735902_exc_R10",
"type": "Subsumes",
"arg1_id": "NCT02735902_exc_T12",
"arg2_id": "NCT02735902_exc_T30",
"normalized": []
},
{
"id": "NCT02735902_exc_R11",
"type": "Has_qualifier",
"arg1_id": "NCT02735902_exc_T34",
"arg2_id": "NCT02735902_exc_T35",
"normalized": []
},
{
"id": "NCT02735902_exc_R12",
"type": "Has_scope",
"arg1_id": "NCT02735902_exc_T32",
"arg2_id": "NCT02735902_exc_T36",
"normalized": []
},
{
"id": "NCT02735902_exc_R13",
"type": "Has_mood",
"arg1_id": "NCT02735902_exc_T32",
"arg2_id": "NCT02735902_exc_T31",
"normalized": []
},
{
"id": "NCT02735902_exc_R14",
"type": "Has_negation",
"arg1_id": "NCT02735902_exc_T31",
"arg2_id": "NCT02735902_exc_T29",
"normalized": []
},
{
"id": "NCT02735902_exc_R15",
"type": "Has_temporal",
"arg1_id": "NCT02735902_exc_T11",
"arg2_id": "NCT02735902_exc_T37",
"normalized": []
},
{
"id": "NCT02735902_exc_R16",
"type": "Has_temporal",
"arg1_id": "NCT02735902_exc_T39",
"arg2_id": "NCT02735902_exc_T40",
"normalized": []
},
{
"id": "NCT02735902_exc_R17",
"type": "Has_temporal",
"arg1_id": "NCT02735902_exc_T39",
"arg2_id": "NCT02735902_exc_T38",
"normalized": []
},
{
"id": "NCT02735902_exc_R19",
"type": "Has_qualifier",
"arg1_id": "NCT02735902_exc_T43",
"arg2_id": "NCT02735902_exc_T44",
"normalized": []
},
{
"id": "NCT02735902_exc_R20",
"type": "Has_scope",
"arg1_id": "NCT02735902_exc_T43",
"arg2_id": "NCT02735902_exc_T46",
"normalized": []
},
{
"id": "NCT02735902_exc_R21",
"type": "Has_qualifier",
"arg1_id": "NCT02735902_exc_T48",
"arg2_id": "NCT02735902_exc_T47",
"normalized": []
},
{
"id": "NCT02735902_exc_R24",
"type": "Has_temporal",
"arg1_id": "NCT02735902_exc_T53",
"arg2_id": "NCT02735902_exc_T54",
"normalized": []
},
{
"id": "NCT02735902_exc_R25",
"type": "Has_qualifier",
"arg1_id": "NCT02735902_exc_T52",
"arg2_id": "NCT02735902_exc_T50",
"normalized": []
},
{
"id": "NCT02735902_exc_R26",
"type": "AND",
"arg1_id": "NCT02735902_exc_T53",
"arg2_id": "NCT02735902_exc_T52",
"normalized": []
},
{
"id": "NCT02735902_exc_R27",
"type": "Has_value",
"arg1_id": "NCT02735902_exc_T55",
"arg2_id": "NCT02735902_exc_T56",
"normalized": []
},
{
"id": "NCT02735902_exc_R28",
"type": "AND",
"arg1_id": "NCT02735902_exc_T52",
"arg2_id": "NCT02735902_exc_T55",
"normalized": []
}
] |
NCT02735902_inc
|
NCT02735902
|
[
{
"id": "NCT02735902_inc_text",
"type": "inclusion",
"text": [
"The patient or his/her representative must have given free and informed consent and signed the consent\nThe patient must be insured or beneficiary of a health insurance plan\nThe patient is available for 12 months of follow-up\nThe patient underwent a successful transcutaneous implant procedure for an aortic valve within the past 24 hours\nThe patient was receiving anti-vitamin K (AVK) treatment before percutaneous implantation of the aortic valve\n"
],
"offsets": [
[
0,
448
]
]
}
] |
[
{
"id": "NCT02735902_inc_T4",
"type": "Procedure",
"text": [
"transcutaneous implant procedure"
],
"offsets": [
[
260,
292
]
],
"normalized": []
},
{
"id": "NCT02735902_inc_T5",
"type": "Device",
"text": [
"aortic valve"
],
"offsets": [
[
300,
312
]
],
"normalized": []
},
{
"id": "NCT02735902_inc_T6",
"type": "Temporal",
"text": [
"past 24 hours"
],
"offsets": [
[
324,
337
]
],
"normalized": []
},
{
"id": "NCT02735902_inc_T7",
"type": "Drug",
"text": [
"anti-vitamin K"
],
"offsets": [
[
364,
378
]
],
"normalized": []
},
{
"id": "NCT02735902_inc_T8",
"type": "Drug",
"text": [
"AVK"
],
"offsets": [
[
380,
383
]
],
"normalized": []
},
{
"id": "NCT02735902_inc_T9",
"type": "Temporal",
"text": [
"before percutaneous implantation of the aortic valve"
],
"offsets": [
[
395,
447
]
],
"normalized": []
},
{
"id": "NCT02735902_inc_T10",
"type": "Reference_point",
"text": [
"percutaneous implantation of the aortic valve"
],
"offsets": [
[
402,
447
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02735902_inc_R1",
"type": "AND",
"arg1_id": "NCT02735902_inc_T4",
"arg2_id": "NCT02735902_inc_T5",
"normalized": []
},
{
"id": "NCT02735902_inc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02735902_inc_T4",
"arg2_id": "NCT02735902_inc_T6",
"normalized": []
},
{
"id": "NCT02735902_inc_R3",
"type": "Has_index",
"arg1_id": "NCT02735902_inc_T9",
"arg2_id": "NCT02735902_inc_T10",
"normalized": []
},
{
"id": "NCT02735902_inc_R4",
"type": "Subsumes",
"arg1_id": "NCT02735902_inc_T7",
"arg2_id": "NCT02735902_inc_T8",
"normalized": []
},
{
"id": "NCT02735902_inc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02735902_inc_T7",
"arg2_id": "NCT02735902_inc_T9",
"normalized": []
}
] |
NCT02739295_exc
|
NCT02739295
|
[
{
"id": "NCT02739295_exc_text",
"type": "exclusion",
"text": [
"Toxic epidermal necrolysis with SCORTEN 6 or 7 at admission\nHypercoagulable state\nCardiac or peripheral arterial disease\nActive malignancy\nMyelodysplastic syndrome or hematological malignancy\nFructose intolerance\nPregnancy\nPatient refusal\n"
],
"offsets": [
[
0,
239
]
]
}
] |
[
{
"id": "NCT02739295_exc_T1",
"type": "Condition",
"text": [
"Toxic epidermal necrolysis"
],
"offsets": [
[
0,
26
]
],
"normalized": []
},
{
"id": "NCT02739295_exc_T2",
"type": "Measurement",
"text": [
"SCORTEN"
],
"offsets": [
[
32,
39
]
],
"normalized": []
},
{
"id": "NCT02739295_exc_T3",
"type": "Value",
"text": [
"6 or 7"
],
"offsets": [
[
40,
46
]
],
"normalized": []
},
{
"id": "NCT02739295_exc_T4",
"type": "Temporal",
"text": [
"at admission"
],
"offsets": [
[
47,
59
]
],
"normalized": []
},
{
"id": "NCT02739295_exc_T5",
"type": "Reference_point",
"text": [
"admission"
],
"offsets": [
[
50,
59
]
],
"normalized": []
},
{
"id": "NCT02739295_exc_T6",
"type": "Condition",
"text": [
"Hypercoagulable state"
],
"offsets": [
[
60,
81
]
],
"normalized": []
},
{
"id": "NCT02739295_exc_T7",
"type": "Condition",
"text": [
"ripheral arterial disease\nA"
],
"offsets": [
[
95,
122
]
],
"normalized": []
},
{
"id": "NCT02739295_exc_T8",
"type": "Condition",
"text": [
"sease\nA",
"rdiac o"
],
"offsets": [
[
115,
122
],
[
84,
91
]
],
"normalized": []
},
{
"id": "NCT02739295_exc_T9",
"type": "Condition",
"text": [
"malignancy"
],
"offsets": [
[
128,
138
]
],
"normalized": []
},
{
"id": "NCT02739295_exc_T10",
"type": "Qualifier",
"text": [
"Active"
],
"offsets": [
[
121,
127
]
],
"normalized": []
},
{
"id": "NCT02739295_exc_T11",
"type": "Condition",
"text": [
"Myelodysplastic syndrome"
],
"offsets": [
[
139,
163
]
],
"normalized": []
},
{
"id": "NCT02739295_exc_T12",
"type": "Condition",
"text": [
"hematological malignancy"
],
"offsets": [
[
167,
191
]
],
"normalized": []
},
{
"id": "NCT02739295_exc_T13",
"type": "Condition",
"text": [
"Fructose intolerance"
],
"offsets": [
[
192,
212
]
],
"normalized": []
},
{
"id": "NCT02739295_exc_T14",
"type": "Drug",
"text": [
"Fructose"
],
"offsets": [
[
192,
200
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02739295_exc_R1",
"type": "Has_index",
"arg1_id": "NCT02739295_exc_T4",
"arg2_id": "NCT02739295_exc_T5",
"normalized": []
},
{
"id": "NCT02739295_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02739295_exc_T9",
"arg2_id": "NCT02739295_exc_T10",
"normalized": []
},
{
"id": "NCT02739295_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02739295_exc_T2",
"arg2_id": "NCT02739295_exc_T4",
"normalized": []
},
{
"id": "NCT02739295_exc_R4",
"type": "Has_value",
"arg1_id": "NCT02739295_exc_T2",
"arg2_id": "NCT02739295_exc_T3",
"normalized": []
}
] |
NCT02739295_inc
|
NCT02739295
|
[
{
"id": "NCT02739295_inc_text",
"type": "inclusion",
"text": [
"Toxic epidermal necrolysis with SCORTEN 1 to 5 at admission\n"
],
"offsets": [
[
0,
60
]
]
}
] |
[
{
"id": "NCT02739295_inc_T1",
"type": "Condition",
"text": [
"Toxic epidermal necrolysis"
],
"offsets": [
[
0,
26
]
],
"normalized": []
},
{
"id": "NCT02739295_inc_T2",
"type": "Measurement",
"text": [
"SCORTEN"
],
"offsets": [
[
32,
39
]
],
"normalized": []
},
{
"id": "NCT02739295_inc_T3",
"type": "Value",
"text": [
"1 to 5"
],
"offsets": [
[
40,
46
]
],
"normalized": []
},
{
"id": "NCT02739295_inc_T4",
"type": "Temporal",
"text": [
"at admission"
],
"offsets": [
[
47,
59
]
],
"normalized": []
},
{
"id": "NCT02739295_inc_T5",
"type": "Reference_point",
"text": [
"admission"
],
"offsets": [
[
50,
59
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02739295_inc_R1",
"type": "Has_index",
"arg1_id": "NCT02739295_inc_T4",
"arg2_id": "NCT02739295_inc_T5",
"normalized": []
},
{
"id": "NCT02739295_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02739295_inc_T2",
"arg2_id": "NCT02739295_inc_T3",
"normalized": []
},
{
"id": "NCT02739295_inc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02739295_inc_T2",
"arg2_id": "NCT02739295_inc_T4",
"normalized": []
}
] |
NCT02742233_exc
|
NCT02742233
|
[
{
"id": "NCT02742233_exc_text",
"type": "exclusion",
"text": [
"Uncontrolled diabetes\nUlcer infection\nNon-diabetic ulcers Orthopedic or neuromuscular pathologic conditions\n"
],
"offsets": [
[
0,
108
]
]
}
] |
[
{
"id": "NCT02742233_exc_T1",
"type": "Qualifier",
"text": [
"Uncontrolled"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "NCT02742233_exc_T2",
"type": "Condition",
"text": [
"diabetes"
],
"offsets": [
[
13,
21
]
],
"normalized": []
},
{
"id": "NCT02742233_exc_T4",
"type": "Condition",
"text": [
"Ulcer infection"
],
"offsets": [
[
22,
37
]
],
"normalized": []
},
{
"id": "NCT02742233_exc_T3",
"type": "Qualifier",
"text": [
"Non-diabetic"
],
"offsets": [
[
38,
50
]
],
"normalized": []
},
{
"id": "NCT02742233_exc_T5",
"type": "Condition",
"text": [
"ulcers"
],
"offsets": [
[
51,
57
]
],
"normalized": []
},
{
"id": "NCT02742233_exc_T6",
"type": "Condition",
"text": [
"thopedic o",
"thologic conditions"
],
"offsets": [
[
60,
70
],
[
88,
107
]
],
"normalized": []
},
{
"id": "NCT02742233_exc_T7",
"type": "Condition",
"text": [
"neuromuscular pathologic conditions"
],
"offsets": [
[
72,
107
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02742233_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02742233_exc_T5",
"arg2_id": "NCT02742233_exc_T3",
"normalized": []
}
] |
NCT02742233_inc
|
NCT02742233
|
[
{
"id": "NCT02742233_inc_text",
"type": "inclusion",
"text": [
"Diagnosis of diabetes mellitus according to World Health Organization criteria ( treatment with insulin or an oral hypoglycemic agent, twice random glucose measurements major than 200 mg/dl, or a fasting glucose major than 140 mg/dl)\nUlcer located on the legs or feet, stage III or IV (Wagner Classification System)\nThe subject agrees to comply with study protocol requirements and all follow up visit requirements.\n"
],
"offsets": [
[
0,
416
]
]
}
] |
[
{
"id": "NCT02742233_inc_T1",
"type": "Condition",
"text": [
"diabetes mellitus"
],
"offsets": [
[
13,
30
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T2",
"type": "Qualifier",
"text": [
"World Health Organization criteria"
],
"offsets": [
[
44,
78
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T3",
"type": "Drug",
"text": [
"insulin"
],
"offsets": [
[
96,
103
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T4",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
81,
90
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T5",
"type": "Drug",
"text": [
"oral hypoglycemic agent"
],
"offsets": [
[
110,
133
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T6",
"type": "Multiplier",
"text": [
"twice"
],
"offsets": [
[
135,
140
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T7",
"type": "Measurement",
"text": [
"random glucose measurements"
],
"offsets": [
[
141,
168
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T8",
"type": "Value",
"text": [
"major than 200 mg/dl"
],
"offsets": [
[
169,
189
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T9",
"type": "Measurement",
"text": [
"fasting glucose"
],
"offsets": [
[
196,
211
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T10",
"type": "Value",
"text": [
"major than 140 mg/dl"
],
"offsets": [
[
212,
232
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T11",
"type": "Scope",
"text": [
"insulin or an oral hypoglycemic agent"
],
"offsets": [
[
96,
133
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T12",
"type": "Scope",
"text": [
"treatment with insulin or an oral hypoglycemic agent, twice random glucose measurements major than 200 mg/dl, or a fasting glucose major than 140 mg/dl"
],
"offsets": [
[
81,
232
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T13",
"type": "Scope",
"text": [
"diabetes mellitus according to World Health Organization criteria"
],
"offsets": [
[
13,
78
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T14",
"type": "Condition",
"text": [
"Ulcer"
],
"offsets": [
[
234,
239
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T15",
"type": "Qualifier",
"text": [
"legs"
],
"offsets": [
[
255,
259
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T16",
"type": "Qualifier",
"text": [
"feet"
],
"offsets": [
[
263,
267
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T17",
"type": "Measurement",
"text": [
"stage"
],
"offsets": [
[
269,
274
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T18",
"type": "Value",
"text": [
"III or IV"
],
"offsets": [
[
275,
284
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T19",
"type": "Qualifier",
"text": [
"Wagner Classification System"
],
"offsets": [
[
286,
314
]
],
"normalized": []
},
{
"id": "NCT02742233_inc_T20",
"type": "Scope",
"text": [
"legs or feet"
],
"offsets": [
[
255,
267
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02742233_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02742233_inc_T1",
"arg2_id": "NCT02742233_inc_T2",
"normalized": []
},
{
"id": "NCT02742233_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02742233_inc_T9",
"arg2_id": "NCT02742233_inc_T10",
"normalized": []
},
{
"id": "NCT02742233_inc_R3",
"type": "Has_multiplier",
"arg1_id": "NCT02742233_inc_T7",
"arg2_id": "NCT02742233_inc_T6",
"normalized": []
},
{
"id": "NCT02742233_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02742233_inc_T7",
"arg2_id": "NCT02742233_inc_T8",
"normalized": []
},
{
"id": "NCT02742233_inc_R5",
"type": "Has_scope",
"arg1_id": "NCT02742233_inc_T4",
"arg2_id": "NCT02742233_inc_T11",
"normalized": []
},
{
"id": "NCT02742233_inc_R6",
"type": "Subsumes",
"arg1_id": "NCT02742233_inc_T13",
"arg2_id": "NCT02742233_inc_T12",
"normalized": []
},
{
"id": "NCT02742233_inc_R7",
"type": "Has_value",
"arg1_id": "NCT02742233_inc_T17",
"arg2_id": "NCT02742233_inc_T18",
"normalized": []
},
{
"id": "NCT02742233_inc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT02742233_inc_T17",
"arg2_id": "NCT02742233_inc_T19",
"normalized": []
},
{
"id": "NCT02742233_inc_R9",
"type": "Has_scope",
"arg1_id": "NCT02742233_inc_T14",
"arg2_id": "NCT02742233_inc_T20",
"normalized": []
}
] |
NCT02743598_exc
|
NCT02743598
|
[
{
"id": "NCT02743598_exc_text",
"type": "exclusion",
"text": [
"Personal or family history of pancreatitis\nMedullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2)\nGastroparesis\nAllergy to liraglutide or any of the active ingredients in liraglutide or other GLP-1 analogue\nWeight loss drugs other than metformin\nType 1 diabetes mellitus or diabetic ketoacidosis\nKnown major cognitive deficit dementia, history of head trauma with loss of consciousness >30 min, history of stroke, current central nervous system (CNS) disorder such as seizures or opportunistic CNS infection\nRenal insufficiency defined as creatinine clearance < 60 mL/min\nActive opportunistic infections\nPregnancy or breastfeeding\nUnstable cardiovascular disease with hospitalization within 1 year for acute coronary syndrome\nDecompensated heart failure\nSubstance abuse\nActive alcohol or opioid substitution therapy\nSerious or unstable medical or psychological conditions that would compromise the subject's safety for successful participation\n"
],
"offsets": [
[
0,
979
]
]
}
] |
[
{
"id": "NCT02743598_exc_T1",
"type": "Condition",
"text": [
"pancreatitis"
],
"offsets": [
[
30,
42
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T2",
"type": "Condition",
"text": [
"Medullary thyroid carcinoma"
],
"offsets": [
[
43,
70
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T3",
"type": "Condition",
"text": [
"MTC"
],
"offsets": [
[
72,
75
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T4",
"type": "Condition",
"text": [
"Multiple Endocrine Neoplasia Syndrome Type 2"
],
"offsets": [
[
80,
124
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T5",
"type": "Condition",
"text": [
"MEN 2"
],
"offsets": [
[
126,
131
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T6",
"type": "Condition",
"text": [
"Gastroparesis"
],
"offsets": [
[
133,
146
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T7",
"type": "Condition",
"text": [
"Allergy"
],
"offsets": [
[
147,
154
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T8",
"type": "Drug",
"text": [
"liraglutide"
],
"offsets": [
[
158,
169
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T9",
"type": "Drug",
"text": [
"GLP-1 analogue"
],
"offsets": [
[
227,
241
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T10",
"type": "Scope",
"text": [
"liraglutide or any of the active ingredients in liraglutide or other GLP-1 analogue"
],
"offsets": [
[
158,
241
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T11",
"type": "Observation",
"text": [
"Weight loss"
],
"offsets": [
[
242,
253
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T12",
"type": "Negation",
"text": [
"other"
],
"offsets": [
[
260,
265
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T13",
"type": "Drug",
"text": [
"metformin"
],
"offsets": [
[
271,
280
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T14",
"type": "Condition",
"text": [
"Type 1 diabetes mellitus"
],
"offsets": [
[
281,
305
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T15",
"type": "Condition",
"text": [
"diabetic ketoacidosis"
],
"offsets": [
[
309,
330
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T16",
"type": "Condition",
"text": [
"dementia"
],
"offsets": [
[
361,
369
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T17",
"type": "Condition",
"text": [
"cognitive deficit"
],
"offsets": [
[
343,
360
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T18",
"type": "Condition",
"text": [
"head trauma"
],
"offsets": [
[
382,
393
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T19",
"type": "Condition",
"text": [
"loss of consciousness"
],
"offsets": [
[
399,
420
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T20",
"type": "Multiplier",
"text": [
">30 min"
],
"offsets": [
[
421,
428
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T21",
"type": "Condition",
"text": [
"stroke"
],
"offsets": [
[
441,
447
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T22",
"type": "Condition",
"text": [
"l nervous system (CNS)",
"er such"
],
"offsets": [
[
463,
485
],
[
492,
499
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T23",
"type": "Condition",
"text": [
"seizures"
],
"offsets": [
[
503,
511
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T24",
"type": "Condition",
"text": [
"opportunistic CNS infection"
],
"offsets": [
[
515,
542
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T25",
"type": "Scope",
"text": [
"seizures or opportunistic CNS infection"
],
"offsets": [
[
503,
542
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T26",
"type": "Condition",
"text": [
"Renal insufficiency"
],
"offsets": [
[
543,
562
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T27",
"type": "Measurement",
"text": [
"creatinine clearance"
],
"offsets": [
[
574,
594
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T28",
"type": "Value",
"text": [
"< 60 mL/min"
],
"offsets": [
[
595,
606
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T29",
"type": "Condition",
"text": [
"opportunistic infections"
],
"offsets": [
[
614,
638
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T30",
"type": "Qualifier",
"text": [
"Active"
],
"offsets": [
[
607,
613
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T33",
"type": "Visit",
"text": [
"hospitalization"
],
"offsets": [
[
703,
718
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T34",
"type": "Temporal",
"text": [
"within 1 year"
],
"offsets": [
[
719,
732
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T35",
"type": "Condition",
"text": [
"acute coronary syndrome"
],
"offsets": [
[
737,
760
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T32",
"type": "Condition",
"text": [
"Decompensated heart failure"
],
"offsets": [
[
761,
788
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T36",
"type": "Condition",
"text": [
"Substance abuse"
],
"offsets": [
[
789,
804
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T37",
"type": "Procedure",
"text": [
"opioid substitution therapy"
],
"offsets": [
[
823,
850
]
],
"normalized": []
},
{
"id": "NCT02743598_exc_T38",
"type": "Observation",
"text": [
"alcohol"
],
"offsets": [
[
812,
819
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02743598_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT02743598_exc_T4",
"arg2_id": "NCT02743598_exc_T5",
"normalized": []
},
{
"id": "NCT02743598_exc_R2",
"type": "Subsumes",
"arg1_id": "NCT02743598_exc_T2",
"arg2_id": "NCT02743598_exc_T3",
"normalized": []
},
{
"id": "NCT02743598_exc_R3",
"type": "Has_scope",
"arg1_id": "NCT02743598_exc_T7",
"arg2_id": "NCT02743598_exc_T10",
"normalized": []
},
{
"id": "NCT02743598_exc_R4",
"type": "AND",
"arg1_id": "NCT02743598_exc_T11",
"arg2_id": "NCT02743598_exc_T13",
"normalized": []
},
{
"id": "NCT02743598_exc_R5",
"type": "Has_negation",
"arg1_id": "NCT02743598_exc_T13",
"arg2_id": "NCT02743598_exc_T12",
"normalized": []
},
{
"id": "NCT02743598_exc_R6",
"type": "AND",
"arg1_id": "NCT02743598_exc_T16",
"arg2_id": "NCT02743598_exc_T17",
"normalized": []
},
{
"id": "NCT02743598_exc_R7",
"type": "Has_multiplier",
"arg1_id": "NCT02743598_exc_T19",
"arg2_id": "NCT02743598_exc_T20",
"normalized": []
},
{
"id": "NCT02743598_exc_R8",
"type": "AND",
"arg1_id": "NCT02743598_exc_T18",
"arg2_id": "NCT02743598_exc_T19",
"normalized": []
},
{
"id": "NCT02743598_exc_R9",
"type": "Subsumes",
"arg1_id": "NCT02743598_exc_T22",
"arg2_id": "NCT02743598_exc_T25",
"normalized": []
},
{
"id": "NCT02743598_exc_R10",
"type": "AND",
"arg1_id": "NCT02743598_exc_T26",
"arg2_id": "NCT02743598_exc_T27",
"normalized": []
},
{
"id": "NCT02743598_exc_R11",
"type": "Has_value",
"arg1_id": "NCT02743598_exc_T27",
"arg2_id": "NCT02743598_exc_T28",
"normalized": []
},
{
"id": "NCT02743598_exc_R12",
"type": "Has_qualifier",
"arg1_id": "NCT02743598_exc_T29",
"arg2_id": "NCT02743598_exc_T30",
"normalized": []
},
{
"id": "NCT02743598_exc_R13",
"type": "Has_temporal",
"arg1_id": "NCT02743598_exc_T35",
"arg2_id": "NCT02743598_exc_T34",
"normalized": []
},
{
"id": "NCT02743598_exc_R14",
"type": "AND",
"arg1_id": "NCT02743598_exc_T35",
"arg2_id": "NCT02743598_exc_T33",
"normalized": []
}
] |
NCT02743598_inc
|
NCT02743598
|
[
{
"id": "NCT02743598_inc_text",
"type": "inclusion",
"text": [
"HIV controlled on therapy for at least 12 weeks\nViral load < 200 copies\nBMI >27 to 45\nDiagnosis of DM type 2 with A1-C >7 to 15\nParticipants must be willing to comply with all study related procedures\n"
],
"offsets": [
[
0,
201
]
]
}
] |
[
{
"id": "NCT02743598_inc_T1",
"type": "Condition",
"text": [
"HIV"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02743598_inc_T2",
"type": "Qualifier",
"text": [
"controlled"
],
"offsets": [
[
4,
14
]
],
"normalized": []
},
{
"id": "NCT02743598_inc_T3",
"type": "Temporal",
"text": [
"at least 12 weeks"
],
"offsets": [
[
30,
47
]
],
"normalized": []
},
{
"id": "NCT02743598_inc_T4",
"type": "Measurement",
"text": [
"Viral load"
],
"offsets": [
[
48,
58
]
],
"normalized": []
},
{
"id": "NCT02743598_inc_T5",
"type": "Value",
"text": [
"< 200 copies"
],
"offsets": [
[
59,
71
]
],
"normalized": []
},
{
"id": "NCT02743598_inc_T6",
"type": "Person",
"text": [
"BMI"
],
"offsets": [
[
72,
75
]
],
"normalized": []
},
{
"id": "NCT02743598_inc_T7",
"type": "Value",
"text": [
">27 to 45"
],
"offsets": [
[
76,
85
]
],
"normalized": []
},
{
"id": "NCT02743598_inc_T8",
"type": "Condition",
"text": [
"DM type 2"
],
"offsets": [
[
99,
108
]
],
"normalized": []
},
{
"id": "NCT02743598_inc_T9",
"type": "Measurement",
"text": [
"A1-C"
],
"offsets": [
[
114,
118
]
],
"normalized": []
},
{
"id": "NCT02743598_inc_T10",
"type": "Value",
"text": [
">7 to 15"
],
"offsets": [
[
119,
127
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02743598_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02743598_inc_T1",
"arg2_id": "NCT02743598_inc_T2",
"normalized": []
},
{
"id": "NCT02743598_inc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02743598_inc_T1",
"arg2_id": "NCT02743598_inc_T3",
"normalized": []
},
{
"id": "NCT02743598_inc_R3",
"type": "Has_value",
"arg1_id": "NCT02743598_inc_T4",
"arg2_id": "NCT02743598_inc_T5",
"normalized": []
},
{
"id": "NCT02743598_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02743598_inc_T6",
"arg2_id": "NCT02743598_inc_T7",
"normalized": []
},
{
"id": "NCT02743598_inc_R5",
"type": "Has_value",
"arg1_id": "NCT02743598_inc_T9",
"arg2_id": "NCT02743598_inc_T10",
"normalized": []
},
{
"id": "NCT02743598_inc_R6",
"type": "AND",
"arg1_id": "NCT02743598_inc_T8",
"arg2_id": "NCT02743598_inc_T9",
"normalized": []
}
] |
NCT02744976_exc
|
NCT02744976
|
[
{
"id": "NCT02744976_exc_text",
"type": "exclusion",
"text": [
"cardiac or non-cardiac illness with life expectancy of less than two years;\nfailure to advance the IVUS catheter through the culprit lesion;\nacute coronary syndrome\ncongestive heart failure NYHA III-IV\ndiabetes mellitus\nchronic kidney disease\nprevious PCI in the target vessel\nheavily calcified vessels\nallergy to metformin\n"
],
"offsets": [
[
0,
324
]
]
}
] |
[
{
"id": "NCT02744976_exc_T1",
"type": "Condition",
"text": [
"non-cardiac illness"
],
"offsets": [
[
11,
30
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T2",
"type": "Condition",
"text": [
"cardiac",
"illness"
],
"offsets": [
[
0,
7
],
[
23,
30
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T3",
"type": "Observation",
"text": [
"life expectancy"
],
"offsets": [
[
36,
51
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T4",
"type": "Value",
"text": [
"less than two years"
],
"offsets": [
[
55,
74
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T5",
"type": "Device",
"text": [
"IVUS catheter"
],
"offsets": [
[
99,
112
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T6",
"type": "Procedure",
"text": [
"advance the IVUS catheter"
],
"offsets": [
[
87,
112
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T7",
"type": "Qualifier",
"text": [
"failure"
],
"offsets": [
[
76,
83
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T8",
"type": "Qualifier",
"text": [
"culprit lesion"
],
"offsets": [
[
125,
139
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T9",
"type": "Condition",
"text": [
"acute coronary syndrome"
],
"offsets": [
[
141,
164
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T10",
"type": "Condition",
"text": [
"congestive heart failure"
],
"offsets": [
[
165,
189
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T11",
"type": "Measurement",
"text": [
"NYHA"
],
"offsets": [
[
190,
194
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T12",
"type": "Value",
"text": [
"III-IV"
],
"offsets": [
[
195,
201
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T13",
"type": "Condition",
"text": [
"diabetes mellitus"
],
"offsets": [
[
202,
219
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T14",
"type": "Condition",
"text": [
"chronic kidney disease"
],
"offsets": [
[
220,
242
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T15",
"type": "Procedure",
"text": [
"PCI"
],
"offsets": [
[
252,
255
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T16",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
243,
251
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T17",
"type": "Qualifier",
"text": [
"target vessel"
],
"offsets": [
[
263,
276
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T18",
"type": "Qualifier",
"text": [
"target vessel"
],
"offsets": [
[
263,
276
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T19",
"type": "Condition",
"text": [
"heavily calcified vessels"
],
"offsets": [
[
277,
302
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T20",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
303,
310
]
],
"normalized": []
},
{
"id": "NCT02744976_exc_T21",
"type": "Drug",
"text": [
"metformin"
],
"offsets": [
[
314,
323
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02744976_exc_R1",
"type": "Has_value",
"arg1_id": "NCT02744976_exc_T3",
"arg2_id": "NCT02744976_exc_T4",
"normalized": []
},
{
"id": "NCT02744976_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02744976_exc_T6",
"arg2_id": "NCT02744976_exc_T7",
"normalized": []
},
{
"id": "NCT02744976_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02744976_exc_T6",
"arg2_id": "NCT02744976_exc_T8",
"normalized": []
},
{
"id": "NCT02744976_exc_R5",
"type": "Has_value",
"arg1_id": "NCT02744976_exc_T11",
"arg2_id": "NCT02744976_exc_T12",
"normalized": []
},
{
"id": "NCT02744976_exc_R6",
"type": "AND",
"arg1_id": "NCT02744976_exc_T10",
"arg2_id": "NCT02744976_exc_T11",
"normalized": []
},
{
"id": "NCT02744976_exc_R7",
"type": "Has_temporal",
"arg1_id": "NCT02744976_exc_T15",
"arg2_id": "NCT02744976_exc_T16",
"normalized": []
},
{
"id": "NCT02744976_exc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT02744976_exc_T15",
"arg2_id": "NCT02744976_exc_T17",
"normalized": []
},
{
"id": "NCT02744976_exc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT02744976_exc_T15",
"arg2_id": "NCT02744976_exc_T18",
"normalized": []
},
{
"id": "NCT02744976_exc_R10",
"type": "AND",
"arg1_id": "NCT02744976_exc_T20",
"arg2_id": "NCT02744976_exc_T21",
"normalized": []
}
] |
NCT02744976_inc
|
NCT02744976
|
[
{
"id": "NCT02744976_inc_text",
"type": "inclusion",
"text": [
"age =18 and <75 years;\npatients with stable coronary artery disease referred to PCI in an artery suitable for IVUS pullback;\nsigned informed consent before PCI.\n"
],
"offsets": [
[
0,
161
]
]
}
] |
[
{
"id": "NCT02744976_inc_T1",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02744976_inc_T2",
"type": "Value",
"text": [
"=18 and <75 years"
],
"offsets": [
[
4,
21
]
],
"normalized": []
},
{
"id": "NCT02744976_inc_T3",
"type": "Qualifier",
"text": [
"stable"
],
"offsets": [
[
37,
43
]
],
"normalized": []
},
{
"id": "NCT02744976_inc_T4",
"type": "Condition",
"text": [
"coronary artery disease"
],
"offsets": [
[
44,
67
]
],
"normalized": []
},
{
"id": "NCT02744976_inc_T5",
"type": "Procedure",
"text": [
"PCI"
],
"offsets": [
[
80,
83
]
],
"normalized": []
},
{
"id": "NCT02744976_inc_T6",
"type": "Mood",
"text": [
"referred to"
],
"offsets": [
[
68,
79
]
],
"normalized": []
},
{
"id": "NCT02744976_inc_T7",
"type": "Qualifier",
"text": [
"artery suitable for IVUS pullback"
],
"offsets": [
[
90,
123
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02744976_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02744976_inc_T1",
"arg2_id": "NCT02744976_inc_T2",
"normalized": []
},
{
"id": "NCT02744976_inc_R2",
"type": "Has_mood",
"arg1_id": "NCT02744976_inc_T5",
"arg2_id": "NCT02744976_inc_T6",
"normalized": []
},
{
"id": "NCT02744976_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02744976_inc_T5",
"arg2_id": "NCT02744976_inc_T7",
"normalized": []
},
{
"id": "NCT02744976_inc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02744976_inc_T4",
"arg2_id": "NCT02744976_inc_T3",
"normalized": []
}
] |
NCT02745704_exc
|
NCT02745704
|
[
{
"id": "NCT02745704_exc_text",
"type": "exclusion",
"text": [
"Patients with liver cirrhosis, Hepatocellular Carcinoma or other malignancies.\nPatients with other factors causing liver diseases.\nPregnant and lactating women.\nPatients with concomitant HIV infection or congenital immune deficiency diseases.\nPatients with diabetes, autoimmune diseases.\nPatients with important organ dysfunctions.\nPatients with serious complications (e.g., infection, hepatic encephalopathy, hepatorenal syndrome, gastrointestinal bleeding.)\nPatients who receive antineoplastic or immunomodulatory therapy in the past 12 months.\nPatients who can't come back to clinic for follow-up on schedule.\n"
],
"offsets": [
[
0,
613
]
]
}
] |
[
{
"id": "NCT02745704_exc_T1",
"type": "Condition",
"text": [
"liver cirrhosis"
],
"offsets": [
[
14,
29
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T2",
"type": "Condition",
"text": [
"Hepatocellular Carcinoma"
],
"offsets": [
[
31,
55
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T3",
"type": "Condition",
"text": [
"malignancies"
],
"offsets": [
[
65,
77
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T6",
"type": "Condition",
"text": [
"HIV infection"
],
"offsets": [
[
187,
200
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T7",
"type": "Qualifier",
"text": [
"concomitant"
],
"offsets": [
[
175,
186
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T8",
"type": "Condition",
"text": [
"congenital immune deficiency diseases."
],
"offsets": [
[
204,
242
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T9",
"type": "Condition",
"text": [
"diabetes"
],
"offsets": [
[
257,
265
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T10",
"type": "Condition",
"text": [
"autoimmune diseases"
],
"offsets": [
[
267,
286
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T11",
"type": "Condition",
"text": [
"organ dysfunctions"
],
"offsets": [
[
312,
330
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T12",
"type": "Qualifier",
"text": [
"serious"
],
"offsets": [
[
346,
353
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T13",
"type": "Condition",
"text": [
"complications"
],
"offsets": [
[
354,
367
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T14",
"type": "Condition",
"text": [
"infection"
],
"offsets": [
[
375,
384
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T15",
"type": "Condition",
"text": [
"hepatic encephalopathy"
],
"offsets": [
[
386,
408
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T16",
"type": "Condition",
"text": [
"hepatorenal syndrome"
],
"offsets": [
[
410,
430
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T17",
"type": "Condition",
"text": [
"gastrointestinal bleeding"
],
"offsets": [
[
432,
457
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T18",
"type": "Scope",
"text": [
"infection, hepatic encephalopathy, hepatorenal syndrome, gastrointestinal bleeding"
],
"offsets": [
[
375,
457
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T19",
"type": "Procedure",
"text": [
"plastic or imm",
" in th"
],
"offsets": [
[
488,
502
],
[
523,
529
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T20",
"type": "Procedure",
"text": [
"immunomodulatory therapy"
],
"offsets": [
[
499,
523
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T21",
"type": "Temporal",
"text": [
"past 12 months"
],
"offsets": [
[
531,
545
]
],
"normalized": []
},
{
"id": "NCT02745704_exc_T22",
"type": "Scope",
"text": [
"antineoplastic or immunomodulatory therapy"
],
"offsets": [
[
481,
523
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02745704_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02745704_exc_T6",
"arg2_id": "NCT02745704_exc_T7",
"normalized": []
},
{
"id": "NCT02745704_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02745704_exc_T13",
"arg2_id": "NCT02745704_exc_T12",
"normalized": []
},
{
"id": "NCT02745704_exc_R3",
"type": "Subsumes",
"arg1_id": "NCT02745704_exc_T13",
"arg2_id": "NCT02745704_exc_T18",
"normalized": []
},
{
"id": "NCT02745704_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02745704_exc_T22",
"arg2_id": "NCT02745704_exc_T21",
"normalized": []
}
] |
NCT02745704_inc
|
NCT02745704
|
[
{
"id": "NCT02745704_inc_text",
"type": "inclusion",
"text": [
"CHB patients who had received NAs for more than 12 months.\nHepatitis B e antigen (HBeAg)-negative and anti-HBeAg positive.\nHepatitis B surface antigen (HBsAg) positive and <1500 IU/mL.\nHepatitis B virus DNA not detectable(Roche Cobas).\n"
],
"offsets": [
[
0,
236
]
]
}
] |
[
{
"id": "NCT02745704_inc_T1",
"type": "Condition",
"text": [
"CHB"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02745704_inc_T2",
"type": "Drug",
"text": [
"NAs"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "NCT02745704_inc_T3",
"type": "Temporal",
"text": [
"more than 12 months."
],
"offsets": [
[
38,
58
]
],
"normalized": []
},
{
"id": "NCT02745704_inc_T4",
"type": "Measurement",
"text": [
"Hepatitis B e antigen"
],
"offsets": [
[
59,
80
]
],
"normalized": []
},
{
"id": "NCT02745704_inc_T5",
"type": "Value",
"text": [
"negative"
],
"offsets": [
[
89,
97
]
],
"normalized": []
},
{
"id": "NCT02745704_inc_T6",
"type": "Measurement",
"text": [
"anti-HBeAg"
],
"offsets": [
[
102,
112
]
],
"normalized": []
},
{
"id": "NCT02745704_inc_T7",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
113,
121
]
],
"normalized": []
},
{
"id": "NCT02745704_inc_T8",
"type": "Measurement",
"text": [
"HBeAg"
],
"offsets": [
[
82,
87
]
],
"normalized": []
},
{
"id": "NCT02745704_inc_T9",
"type": "Measurement",
"text": [
"Hepatitis B surface antigen"
],
"offsets": [
[
123,
150
]
],
"normalized": []
},
{
"id": "NCT02745704_inc_T10",
"type": "Measurement",
"text": [
"HBsAg"
],
"offsets": [
[
152,
157
]
],
"normalized": []
},
{
"id": "NCT02745704_inc_T11",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
159,
167
]
],
"normalized": []
},
{
"id": "NCT02745704_inc_T12",
"type": "Value",
"text": [
"<1500 IU/mL"
],
"offsets": [
[
172,
183
]
],
"normalized": []
},
{
"id": "NCT02745704_inc_T13",
"type": "Measurement",
"text": [
"Hepatitis B virus DNA"
],
"offsets": [
[
185,
206
]
],
"normalized": []
},
{
"id": "NCT02745704_inc_T14",
"type": "Value",
"text": [
"not detectable"
],
"offsets": [
[
207,
221
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02745704_inc_R1",
"type": "AND",
"arg1_id": "NCT02745704_inc_T1",
"arg2_id": "NCT02745704_inc_T2",
"normalized": []
},
{
"id": "NCT02745704_inc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02745704_inc_T2",
"arg2_id": "NCT02745704_inc_T3",
"normalized": []
},
{
"id": "NCT02745704_inc_R3",
"type": "Has_value",
"arg1_id": "NCT02745704_inc_T4",
"arg2_id": "NCT02745704_inc_T5",
"normalized": []
},
{
"id": "NCT02745704_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02745704_inc_T6",
"arg2_id": "NCT02745704_inc_T7",
"normalized": []
},
{
"id": "NCT02745704_inc_R5",
"type": "Subsumes",
"arg1_id": "NCT02745704_inc_T4",
"arg2_id": "NCT02745704_inc_T8",
"normalized": []
},
{
"id": "NCT02745704_inc_R6",
"type": "Subsumes",
"arg1_id": "NCT02745704_inc_T9",
"arg2_id": "NCT02745704_inc_T10",
"normalized": []
},
{
"id": "NCT02745704_inc_R7",
"type": "Has_value",
"arg1_id": "NCT02745704_inc_T9",
"arg2_id": "NCT02745704_inc_T11",
"normalized": []
},
{
"id": "NCT02745704_inc_R8",
"type": "Has_value",
"arg1_id": "NCT02745704_inc_T9",
"arg2_id": "NCT02745704_inc_T12",
"normalized": []
},
{
"id": "NCT02745704_inc_R9",
"type": "Has_value",
"arg1_id": "NCT02745704_inc_T13",
"arg2_id": "NCT02745704_inc_T14",
"normalized": []
}
] |
NCT02746900_exc
|
NCT02746900
|
[
{
"id": "NCT02746900_exc_text",
"type": "exclusion",
"text": [
"Multiple pregnancy\nPrior spontaneous preterm birth or second trimester losses between 16(0) and 36(6) weeks\nCerclage in situ\nPainful regular uterine contraction and/or preterm labor\nRuptured membranes\nMajor fetal defects\nActive vaginal bleeding\nPlacenda previa and/or accreta\nCervical dilation >1.5 cm and/or visible membranes by pelvic exam\nSuspicion of chorioamnionitis\n"
],
"offsets": [
[
0,
372
]
]
}
] |
[
{
"id": "NCT02746900_exc_T1",
"type": "Condition",
"text": [
"Multiple pregnancy"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T2",
"type": "Temporal",
"text": [
"Prior"
],
"offsets": [
[
19,
24
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T3",
"type": "Condition",
"text": [
"spontaneous preterm birth"
],
"offsets": [
[
25,
50
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T4",
"type": "Condition",
"text": [
"losses"
],
"offsets": [
[
71,
77
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T5",
"type": "Qualifier",
"text": [
"between 16(0) and 36(6) weeks"
],
"offsets": [
[
78,
107
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T6",
"type": "Qualifier",
"text": [
"second trimester"
],
"offsets": [
[
54,
70
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T7",
"type": "Scope",
"text": [
"spontaneous preterm birth or second trimester losses between 16(0) and 36(6) weeks"
],
"offsets": [
[
25,
107
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T8",
"type": "Condition",
"text": [
"Cerclage in situ"
],
"offsets": [
[
108,
124
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T9",
"type": "Condition",
"text": [
"Painful regular uterine contraction"
],
"offsets": [
[
125,
160
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T10",
"type": "Condition",
"text": [
"preterm labor"
],
"offsets": [
[
168,
181
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T11",
"type": "Condition",
"text": [
"Ruptured membranes"
],
"offsets": [
[
182,
200
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T12",
"type": "Condition",
"text": [
"Major fetal defects"
],
"offsets": [
[
201,
220
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T13",
"type": "Condition",
"text": [
"Active vaginal bleeding"
],
"offsets": [
[
221,
244
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T14",
"type": "Condition",
"text": [
"Placenda previa"
],
"offsets": [
[
245,
260
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T15",
"type": "Condition",
"text": [
"accreta"
],
"offsets": [
[
268,
275
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T16",
"type": "Measurement",
"text": [
"Cervical dilation"
],
"offsets": [
[
276,
293
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T17",
"type": "Value",
"text": [
">1.5 cm"
],
"offsets": [
[
294,
301
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T18",
"type": "Condition",
"text": [
"visible membranes"
],
"offsets": [
[
309,
326
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T19",
"type": "Procedure",
"text": [
"pelvic exam"
],
"offsets": [
[
330,
341
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T20",
"type": "Mood",
"text": [
"Suspicion of"
],
"offsets": [
[
342,
354
]
],
"normalized": []
},
{
"id": "NCT02746900_exc_T21",
"type": "Condition",
"text": [
"chorioamnionitis"
],
"offsets": [
[
355,
371
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02746900_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02746900_exc_T4",
"arg2_id": "NCT02746900_exc_T5",
"normalized": []
},
{
"id": "NCT02746900_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02746900_exc_T4",
"arg2_id": "NCT02746900_exc_T6",
"normalized": []
},
{
"id": "NCT02746900_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02746900_exc_T7",
"arg2_id": "NCT02746900_exc_T2",
"normalized": []
},
{
"id": "NCT02746900_exc_R4",
"type": "Has_value",
"arg1_id": "NCT02746900_exc_T16",
"arg2_id": "NCT02746900_exc_T17",
"normalized": []
},
{
"id": "NCT02746900_exc_R5",
"type": "AND",
"arg1_id": "NCT02746900_exc_T19",
"arg2_id": "NCT02746900_exc_T18",
"normalized": []
},
{
"id": "NCT02746900_exc_R6",
"type": "Has_mood",
"arg1_id": "NCT02746900_exc_T21",
"arg2_id": "NCT02746900_exc_T20",
"normalized": []
}
] |
NCT02746900_inc
|
NCT02746900
|
[
{
"id": "NCT02746900_inc_text",
"type": "inclusion",
"text": [
"18-50 ages\nSingleton pregnancy\nCervical length <=25mm between 18(0) and 23(6) weeks\n"
],
"offsets": [
[
0,
84
]
]
}
] |
[
{
"id": "NCT02746900_inc_T1",
"type": "Person",
"text": [
"ages"
],
"offsets": [
[
6,
10
]
],
"normalized": []
},
{
"id": "NCT02746900_inc_T2",
"type": "Value",
"text": [
"18-50"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02746900_inc_T3",
"type": "Measurement",
"text": [
"Cervical length"
],
"offsets": [
[
31,
46
]
],
"normalized": []
},
{
"id": "NCT02746900_inc_T4",
"type": "Value",
"text": [
"<=25mm"
],
"offsets": [
[
47,
53
]
],
"normalized": []
},
{
"id": "NCT02746900_inc_T5",
"type": "Qualifier",
"text": [
"between 18(0) and 23(6) weeks"
],
"offsets": [
[
54,
83
]
],
"normalized": []
},
{
"id": "NCT02746900_inc_T6",
"type": "Condition",
"text": [
"Singleton pregnancy"
],
"offsets": [
[
11,
30
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02746900_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02746900_inc_T1",
"arg2_id": "NCT02746900_inc_T2",
"normalized": []
},
{
"id": "NCT02746900_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02746900_inc_T3",
"arg2_id": "NCT02746900_inc_T5",
"normalized": []
},
{
"id": "NCT02746900_inc_R3",
"type": "Has_value",
"arg1_id": "NCT02746900_inc_T3",
"arg2_id": "NCT02746900_inc_T4",
"normalized": []
}
] |
NCT02747940_exc
|
NCT02747940
|
[
{
"id": "NCT02747940_exc_text",
"type": "exclusion",
"text": [
"history of major systemic illness, including uncontrolled hypertension, diabetes, chronic renal insufficiency, autoimmune diseases or malignancies\nhistory of neurological disorders which might affect sensation such as previous stroke or peripheral neuropathy\nhistory of substance abuse (except painkillers)\nheavy smokers (with a daily consumption >20 cigarettes)\npregnancy or lactation\nany contraindication for magnetic resonance imaging (MRI)\nand any obvious infection or inflammation over a period of at least 1 month before the study.\n"
],
"offsets": [
[
0,
538
]
]
}
] |
[
{
"id": "NCT02747940_exc_T1",
"type": "Condition",
"text": [
"systemic illness"
],
"offsets": [
[
17,
33
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T2",
"type": "Qualifier",
"text": [
"major"
],
"offsets": [
[
11,
16
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T3",
"type": "Condition",
"text": [
"hypertension"
],
"offsets": [
[
58,
70
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T4",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
45,
57
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T5",
"type": "Condition",
"text": [
"diabetes"
],
"offsets": [
[
72,
80
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T6",
"type": "Condition",
"text": [
"chronic renal insufficiency,"
],
"offsets": [
[
82,
110
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T7",
"type": "Condition",
"text": [
"autoimmune diseases"
],
"offsets": [
[
111,
130
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T8",
"type": "Condition",
"text": [
"malignancies"
],
"offsets": [
[
134,
146
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T9",
"type": "Scope",
"text": [
"uncontrolled hypertension, diabetes, chronic renal insufficiency, autoimmune diseases or malignancies"
],
"offsets": [
[
45,
146
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T10",
"type": "Condition",
"text": [
"neurological disorders"
],
"offsets": [
[
158,
180
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T11",
"type": "Condition",
"text": [
"stroke"
],
"offsets": [
[
227,
233
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T12",
"type": "Condition",
"text": [
"peripheral neuropathy"
],
"offsets": [
[
237,
258
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T13",
"type": "Condition",
"text": [
"affect sensation"
],
"offsets": [
[
193,
209
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T14",
"type": "Scope",
"text": [
"stroke or peripheral neuropathy"
],
"offsets": [
[
227,
258
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T15",
"type": "Condition",
"text": [
"substance abuse"
],
"offsets": [
[
270,
285
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T16",
"type": "Negation",
"text": [
"except"
],
"offsets": [
[
287,
293
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T17",
"type": "Drug",
"text": [
"painkillers"
],
"offsets": [
[
294,
305
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T18",
"type": "Qualifier",
"text": [
"heavy"
],
"offsets": [
[
307,
312
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T19",
"type": "Person",
"text": [
"smokers"
],
"offsets": [
[
313,
320
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T20",
"type": "Observation",
"text": [
"cigarettes"
],
"offsets": [
[
351,
361
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T21",
"type": "Multiplier",
"text": [
"daily consumption >20"
],
"offsets": [
[
329,
350
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T23",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
390,
406
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T24",
"type": "Procedure",
"text": [
"magnetic resonance imaging"
],
"offsets": [
[
411,
437
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T25",
"type": "Procedure",
"text": [
"MRI"
],
"offsets": [
[
439,
442
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T26",
"type": "Condition",
"text": [
"infection"
],
"offsets": [
[
460,
469
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T27",
"type": "Condition",
"text": [
"inflammation"
],
"offsets": [
[
473,
485
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T28",
"type": "Temporal",
"text": [
"at least 1 month before the study"
],
"offsets": [
[
503,
536
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T29",
"type": "Reference_point",
"text": [
"study"
],
"offsets": [
[
531,
536
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T30",
"type": "Scope",
"text": [
"infection or inflammation"
],
"offsets": [
[
460,
485
]
],
"normalized": []
},
{
"id": "NCT02747940_exc_T31",
"type": "Qualifier",
"text": [
"obvious"
],
"offsets": [
[
452,
459
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02747940_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02747940_exc_T1",
"arg2_id": "NCT02747940_exc_T2",
"normalized": []
},
{
"id": "NCT02747940_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02747940_exc_T3",
"arg2_id": "NCT02747940_exc_T4",
"normalized": []
},
{
"id": "NCT02747940_exc_R3",
"type": "Subsumes",
"arg1_id": "NCT02747940_exc_T1",
"arg2_id": "NCT02747940_exc_T9",
"normalized": []
},
{
"id": "NCT02747940_exc_R4",
"type": "AND",
"arg1_id": "NCT02747940_exc_T10",
"arg2_id": "NCT02747940_exc_T13",
"normalized": []
},
{
"id": "NCT02747940_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT02747940_exc_T10",
"arg2_id": "NCT02747940_exc_T14",
"normalized": []
},
{
"id": "NCT02747940_exc_R6",
"type": "Has_negation",
"arg1_id": "NCT02747940_exc_T17",
"arg2_id": "NCT02747940_exc_T16",
"normalized": []
},
{
"id": "NCT02747940_exc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02747940_exc_T19",
"arg2_id": "NCT02747940_exc_T18",
"normalized": []
},
{
"id": "NCT02747940_exc_R8",
"type": "Has_multiplier",
"arg1_id": "NCT02747940_exc_T20",
"arg2_id": "NCT02747940_exc_T21",
"normalized": []
},
{
"id": "NCT02747940_exc_R9",
"type": "Subsumes",
"arg1_id": "NCT02747940_exc_T24",
"arg2_id": "NCT02747940_exc_T25",
"normalized": []
},
{
"id": "NCT02747940_exc_R10",
"type": "AND",
"arg1_id": "NCT02747940_exc_T23",
"arg2_id": "NCT02747940_exc_T24",
"normalized": []
},
{
"id": "NCT02747940_exc_R11",
"type": "Has_index",
"arg1_id": "NCT02747940_exc_T28",
"arg2_id": "NCT02747940_exc_T29",
"normalized": []
},
{
"id": "NCT02747940_exc_R12",
"type": "Has_temporal",
"arg1_id": "NCT02747940_exc_T30",
"arg2_id": "NCT02747940_exc_T28",
"normalized": []
},
{
"id": "NCT02747940_exc_R13",
"type": "Has_qualifier",
"arg1_id": "NCT02747940_exc_T30",
"arg2_id": "NCT02747940_exc_T31",
"normalized": []
}
] |
NCT02747940_inc
|
NCT02747940
|
[
{
"id": "NCT02747940_inc_text",
"type": "inclusion",
"text": [
"Control: devoid of any systemic or neurological diseases\nChronic migraine: by ICHD-III (International Classification of Headache Disorder) criteria\nFibromyalgia: by ACR (American College of Rheumatology) 2010 criteria\n"
],
"offsets": [
[
0,
218
]
]
}
] |
[
{
"id": "NCT02747940_inc_T1",
"type": "Negation",
"text": [
"devoid"
],
"offsets": [
[
9,
15
]
],
"normalized": []
},
{
"id": "NCT02747940_inc_T2",
"type": "Condition",
"text": [
"neurological diseases"
],
"offsets": [
[
35,
56
]
],
"normalized": []
},
{
"id": "NCT02747940_inc_T3",
"type": "Condition",
"text": [
"systemic",
"diseases"
],
"offsets": [
[
23,
31
],
[
48,
56
]
],
"normalized": []
},
{
"id": "NCT02747940_inc_T4",
"type": "Scope",
"text": [
"systemic or neurological diseases"
],
"offsets": [
[
23,
56
]
],
"normalized": []
},
{
"id": "NCT02747940_inc_T5",
"type": "Condition",
"text": [
"Chronic migraine"
],
"offsets": [
[
57,
73
]
],
"normalized": []
},
{
"id": "NCT02747940_inc_T6",
"type": "Qualifier",
"text": [
"ICHD-III"
],
"offsets": [
[
78,
86
]
],
"normalized": []
},
{
"id": "NCT02747940_inc_T7",
"type": "Qualifier",
"text": [
"International Classification of Headache Disorder"
],
"offsets": [
[
88,
137
]
],
"normalized": []
},
{
"id": "NCT02747940_inc_T8",
"type": "Condition",
"text": [
"Fibromyalgia"
],
"offsets": [
[
148,
160
]
],
"normalized": []
},
{
"id": "NCT02747940_inc_T9",
"type": "Qualifier",
"text": [
"American College of Rheumatology"
],
"offsets": [
[
170,
202
]
],
"normalized": []
},
{
"id": "NCT02747940_inc_T10",
"type": "Qualifier",
"text": [
"R (",
"10 criteria"
],
"offsets": [
[
167,
170
],
[
206,
217
]
],
"normalized": []
}
] |
[] |
[] |
[
{
"id": "NCT02747940_inc_R1",
"type": "Has_negation",
"arg1_id": "NCT02747940_inc_T4",
"arg2_id": "NCT02747940_inc_T1",
"normalized": []
},
{
"id": "NCT02747940_inc_R2",
"type": "Subsumes",
"arg1_id": "NCT02747940_inc_T6",
"arg2_id": "NCT02747940_inc_T7",
"normalized": []
},
{
"id": "NCT02747940_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02747940_inc_T5",
"arg2_id": "NCT02747940_inc_T6",
"normalized": []
},
{
"id": "NCT02747940_inc_R4",
"type": "Subsumes",
"arg1_id": "NCT02747940_inc_T10",
"arg2_id": "NCT02747940_inc_T9",
"normalized": []
},
{
"id": "NCT02747940_inc_R5",
"type": "AND",
"arg1_id": "NCT02747940_inc_T10",
"arg2_id": "NCT02747940_inc_T8",
"normalized": []
}
] |
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