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DS.d1244
|
18803297
|
[
{
"id": "DS.d1244.s0",
"type": "",
"text": [
"A vitreous fraction showing growth-promoting activity 1000 Da, consistent with ascorbic acid."
],
"offsets": [
[
0,
93
]
]
}
] |
[
{
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28,
53
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{
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{
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]
}
] |
[] |
[] |
[] |
DS.d1245
|
18803462
|
[
{
"id": "DS.d1245.s0",
"type": "",
"text": [
"The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast."
],
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0,
319
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[
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29,
41
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{
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{
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132
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]
}
] |
[] |
[] |
[] |
DS.d1246
|
18803582
|
[
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"type": "",
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"A specific digoxigenin-labelled probe, obtained by PCR amplification of a 270-bp fragment of the gene coding the LCDV major capsid protein, was used for ISH."
],
"offsets": [
[
0,
157
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]
}
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[
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[] |
[] |
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}
] |
DS.d1247
|
18803655
|
[
{
"id": "DS.d1247.s0",
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],
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}
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]
}
] |
[] |
[] |
[] |
DS.d1248
|
18804292
|
[
{
"id": "DS.d1248.s0",
"type": "",
"text": [
"No differences in estradiol, testosterone, or vitellogenin plasma concentrations were observed in exposed males or females compared to controls."
],
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[
0,
144
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]
}
] |
[
{
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18,
27
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},
{
"id": "DS.d1248.s0.e1",
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29,
41
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]
},
{
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58
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],
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{
"db_name": "UniProt",
"db_id": "P19615"
}
]
}
] |
[] |
[] |
[] |
DS.d1249
|
18804314
|
[
{
"id": "DS.d1249.s0",
"type": "",
"text": [
"Macrophages located in the media differentiate into giant cells and/or produce reactive oxygen species, nitric oxide and matrix metallo-proteinases."
],
"offsets": [
[
0,
148
]
]
}
] |
[
{
"id": "DS.d1249.s0.e0",
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88,
94
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]
},
{
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104,
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]
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] |
[] |
[] |
[] |
DS.d1250
|
18804365
|
[
{
"id": "DS.d1250.s0",
"type": "",
"text": [
"Having compared four kinds of antibody immobilizations on Au surface, an optimized mAb 8G3 was immobilized onto the Au electrode with protein A on a mixed self-assembled monolayer (SAM) of 11-mercaptoundecanoic acid (11-MUA) and 6-mercaptohexan-1-ol (6-MHO) as adhesive layer."
],
"offsets": [
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276
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[
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[] |
[] |
[] |
DS.d1251
|
18804521
|
[
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[] |
[] |
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DS.d1252
|
18804525
|
[
{
"id": "DS.d1252.s0",
"type": "",
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0,
192
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]
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{
"id": "DS.d1252.s1",
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],
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193,
441
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]
}
] |
[
{
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53,
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},
{
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[] |
[] |
[] |
DS.d1253
|
18804848
|
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[] |
[] |
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] |
DS.d1254
|
18804908
|
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[] |
[] |
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] |
DS.d1255
|
18804927
|
[
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DS.d1257
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18804984
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DS.d1258
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18805402
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DS.d1259
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18805433
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DS.d1260
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18805442
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DS.d1261
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18805484
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DS.d1262
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18805505
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}
] |
DS.d1263
|
18805508
|
[
{
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"type": "",
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],
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0,
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]
}
] |
[
{
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},
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}
] |
[] |
[] |
[] |
DS.d1264
|
18805632
|
[
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0,
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}
] |
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]
}
] |
[] |
[] |
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}
] |
DS.d1265
|
18805639
|
[
{
"id": "DS.d1265.s0",
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] |
[] |
[] |
[] |
DS.d1266
|
18805685
|
[
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],
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252,
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]
}
] |
[
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},
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]
}
] |
[] |
[] |
[] |
DS.d1267
|
18806218
|
[
{
"id": "DS.d1267.s0",
"type": "",
"text": [
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0,
83
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]
}
] |
[
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]
},
{
"id": "DS.d1267.s0.e1",
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],
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{
"db_name": "PubChem",
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]
}
] |
[] |
[] |
[
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"normalized": []
}
] |
DS.d1268
|
18806296
|
[
{
"id": "DS.d1268.s0",
"type": "",
"text": [
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],
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0,
151
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]
}
] |
[
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{
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101,
107
]
],
"normalized": [
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}
]
}
] |
[] |
[] |
[] |
DS.d1269
|
18806930
|
[
{
"id": "DS.d1269.s0",
"type": "",
"text": [
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],
"offsets": [
[
0,
208
]
]
}
] |
[
{
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"text": [
"GLUT-1"
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156,
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]
},
{
"id": "DS.d1269.s0.e1",
"type": "compound",
"text": [
"oxythiamine"
],
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196,
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]
],
"normalized": [
{
"db_name": "PubChem",
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}
]
}
] |
[] |
[] |
[] |
DS.d1270
|
18806932
|
[
{
"id": "DS.d1270.s0",
"type": "",
"text": [
"Magnesium (Mg), interleukin 8 (IL-8), and malondialdehyde levels were analyzed in blood, while edema, neutrophil infiltration, eosinophilia, loss of striation, and nucleolization were evaluated in histopathological examination."
],
"offsets": [
[
0,
227
]
]
}
] |
[
{
"id": "DS.d1270.s0.e0",
"type": "compound",
"text": [
"Magnesium"
],
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[
0,
9
]
],
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{
"db_name": "PubChem",
"db_id": "5462224"
}
]
},
{
"id": "DS.d1270.s0.e1",
"type": "protein",
"text": [
"interleukin 8"
],
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16,
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]
},
{
"id": "DS.d1270.s0.e2",
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"text": [
"IL-8"
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31,
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{
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{
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{
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},
{
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},
{
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},
{
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{
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{
"db_name": "UniProt",
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{
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},
{
"db_name": "UniProt",
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},
{
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},
{
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}
]
},
{
"id": "DS.d1270.s0.e3",
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"malondialdehyde"
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42,
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]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "10964"
}
]
}
] |
[] |
[] |
[] |
DS.d1271
|
18807018
|
[
{
"id": "DS.d1271.s0",
"type": "",
"text": [
"Study of multiple binding constants of dexamethasone with human serum albumin by capillary electrophoresis-frontal analysis and multivariate regression."
],
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[
0,
152
]
]
},
{
"id": "DS.d1271.s1",
"type": "",
"text": [
"In this paper, to evaluate the pharmacokinetic and pharmacodynamic properties of dexamethasone (DXM), the interaction between DXM and HSA was studied by capillary electrophoresis-frontal analysis (CE-FA)."
],
"offsets": [
[
153,
357
]
]
}
] |
[
{
"id": "DS.d1271.s0.e0",
"type": "compound",
"text": [
"dexamethasone"
],
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[
39,
52
]
],
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}
]
},
{
"id": "DS.d1271.s0.e1",
"type": "protein",
"text": [
"serum albumin"
],
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64,
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],
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{
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}
]
},
{
"id": "DS.d1271.s1.e0",
"type": "compound",
"text": [
"dexamethasone"
],
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]
},
{
"id": "DS.d1271.s1.e1",
"type": "protein",
"text": [
"HSA"
],
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[
287,
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]
],
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{
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"db_id": "P24807"
},
{
"db_name": "UniProt",
"db_id": "Q07490"
}
]
}
] |
[] |
[] |
[
{
"id": "DS.d1271.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d1271.s0.e0",
"arg2_id": "DS.d1271.s0.e1",
"normalized": []
},
{
"id": "DS.d1271.s1.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d1271.s1.e0",
"arg2_id": "DS.d1271.s1.e1",
"normalized": []
}
] |
DS.d1272
|
18807050
|
[
{
"id": "DS.d1272.s0",
"type": "",
"text": [
"Arthropod hemocyanins transport and store oxygen and are composed of six subunits, or multiples thereof depending on the species."
],
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[
0,
129
]
]
},
{
"id": "DS.d1272.s1",
"type": "",
"text": [
"The protein is insensitive to lactate, but affected by urate which markedly increased hemocyanin-oxygen affinity, acting as the physiological major positive effector."
],
"offsets": [
[
130,
296
]
]
}
] |
[
{
"id": "DS.d1272.s0.e0",
"type": "protein",
"text": [
"hemocyanins"
],
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[
10,
21
]
],
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}
]
},
{
"id": "DS.d1272.s0.e1",
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"text": [
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42,
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]
},
{
"id": "DS.d1272.s1.e0",
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"text": [
"hemocyanin"
],
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216,
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],
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]
},
{
"id": "DS.d1272.s1.e1",
"type": "compound",
"text": [
"oxygen"
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[
227,
233
]
],
"normalized": [
{
"db_name": "PubChem",
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}
]
}
] |
[] |
[] |
[
{
"id": "DS.d1272.s1.i0",
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"arg1_id": "DS.d1272.s1.e1",
"arg2_id": "DS.d1272.s1.e0",
"normalized": []
}
] |
DS.d1273
|
18807177
|
[
{
"id": "DS.d1273.s0",
"type": "",
"text": [
"The estrogen-induced increase in CXCR4 protein in MCF-7-HER2 cells was abrogated by the antiestrogen ICI 182780 and by gefitinib (Iressa ; a phospho-tyrosine kinase inhibitor), indicating an ER-mediated effect and confirming involvement of receptor tyrosine kinases, respectively."
],
"offsets": [
[
0,
280
]
]
}
] |
[
{
"id": "DS.d1273.s0.e0",
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],
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[
33,
38
]
],
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},
{
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},
{
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"db_id": "P56491"
},
{
"db_name": "UniProt",
"db_id": "P56498"
},
{
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},
{
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},
{
"db_name": "UniProt",
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},
{
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},
{
"db_name": "UniProt",
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},
{
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},
{
"db_name": "UniProt",
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},
{
"db_name": "UniProt",
"db_id": "Q8HZU0"
},
{
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},
{
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}
]
},
{
"id": "DS.d1273.s0.e1",
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]
},
{
"id": "DS.d1273.s0.e2",
"type": "compound",
"text": [
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]
},
{
"id": "DS.d1273.s0.e3",
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130,
136
]
],
"normalized": [
{
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}
]
}
] |
[] |
[] |
[
{
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"arg1_id": "DS.d1273.s0.e3",
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},
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},
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}
] |
DS.d1274
|
18807200
|
[
{
"id": "DS.d1274.s0",
"type": "",
"text": [
"Enzymatic activities of an H(2)O(2) independent oxidase along with laccase and an azoreductase suggest their prominent role during the decolorization of reactive yellow 84A."
],
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[
0,
173
]
]
},
{
"id": "DS.d1274.s1",
"type": "",
"text": [
"Azoreductase activity was prominent in presence of cofactors NADH and NADP in mineral salt medium."
],
"offsets": [
[
174,
272
]
]
}
] |
[
{
"id": "DS.d1274.s0.e0",
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"laccase"
],
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[
67,
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]
],
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"db_id": "Q12570"
}
]
},
{
"id": "DS.d1274.s0.e1",
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],
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82,
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]
],
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},
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},
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},
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}
]
},
{
"id": "DS.d1274.s0.e2",
"type": "compound",
"text": [
"84A"
],
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[
169,
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]
],
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{
"db_name": "PubChem",
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}
]
},
{
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174,
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},
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},
{
"db_name": "UniProt",
"db_id": "Q8CHK7"
}
]
},
{
"id": "DS.d1274.s1.e1",
"type": "compound",
"text": [
"NADH"
],
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235,
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]
],
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}
]
},
{
"id": "DS.d1274.s1.e2",
"type": "compound",
"text": [
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244,
248
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "5886"
}
]
}
] |
[] |
[] |
[
{
"id": "DS.d1274.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d1274.s0.e2",
"arg2_id": "DS.d1274.s0.e0",
"normalized": []
},
{
"id": "DS.d1274.s0.i1",
"type": "compound-protein-interaction",
"arg1_id": "DS.d1274.s0.e2",
"arg2_id": "DS.d1274.s0.e1",
"normalized": []
},
{
"id": "DS.d1274.s1.i0",
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},
{
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"arg1_id": "DS.d1274.s1.e2",
"arg2_id": "DS.d1274.s1.e0",
"normalized": []
}
] |
DS.d1275
|
18807214
|
[
{
"id": "DS.d1275.s0",
"type": "",
"text": [
"The increase of oxygen availability caused the induction of the antioxidant enzyme superoxide dismutase, which indicates that the defensive mechanisms of the cells against oxidative stress were effective and cells could cope with increased pressure."
],
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[
0,
249
]
]
}
] |
[
{
"id": "DS.d1275.s0.e0",
"type": "compound",
"text": [
"oxygen"
],
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[
16,
22
]
],
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}
]
},
{
"id": "DS.d1275.s0.e1",
"type": "protein",
"text": [
"superoxide dismutase"
],
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[
83,
103
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "O50258"
}
]
}
] |
[] |
[] |
[
{
"id": "DS.d1275.s0.i0",
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"arg1_id": "DS.d1275.s0.e0",
"arg2_id": "DS.d1275.s0.e1",
"normalized": []
}
] |
DS.d1276
|
18808217
|
[
{
"id": "DS.d1276.s0",
"type": "",
"text": [
"Concentrations of aqueous-phase perfluorooctanoic acid (PFOA), a representative perfluorinated aliphatic (PFA) compound, are shown to be reduced effectively via reaction with horseradish peroxidase (HRP), hydrogen peroxide, and a phenolic cosubstrate (4-methoxyphenol)."
],
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0,
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]
]
},
{
"id": "DS.d1276.s1",
"type": "",
"text": [
"Approximately 68% depletion of the parent compound and 98% depletion of its related acute aquatic toxicity are achieved in 6 h. Because no PFOA removal is observed in the absence of cosubstrate and/or following consumption thereof, we conclude that radical intermediate species generated during reaction between HRP and 4-methoxyphenol mediate nonspecific depletion of PFOA and that these intermediates may be sufficiently reactive to sever the extremely stable C-F bonds of PFOA."
],
"offsets": [
[
270,
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]
]
}
] |
[
{
"id": "DS.d1276.s0.e0",
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],
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187,
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]
],
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"db_id": "P16147"
},
{
"db_name": "UniProt",
"db_id": "P84714"
}
]
},
{
"id": "DS.d1276.s0.e1",
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],
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}
]
},
{
"id": "DS.d1276.s0.e2",
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"text": [
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]
},
{
"id": "DS.d1276.s0.e3",
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"db_id": "9015"
}
]
},
{
"id": "DS.d1276.s1.e0",
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"text": [
"HRP"
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]
},
{
"id": "DS.d1276.s1.e1",
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"text": [
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]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "9015"
}
]
}
] |
[] |
[] |
[
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},
{
"id": "DS.d1276.s0.i1",
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"arg2_id": "DS.d1276.s0.e0",
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},
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},
{
"id": "DS.d1276.s0.i3",
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"arg2_id": "DS.d1276.s1.e0",
"normalized": []
}
] |
DS.d1277
|
18808365
|
[
{
"id": "DS.d1277.s0",
"type": "",
"text": [
"In the present study, the mRNA expression and promoter CpG methylation of ERalpha isoforms (i.e."
],
"offsets": [
[
0,
96
]
]
},
{
"id": "DS.d1277.s1",
"type": "",
"text": [
"The present study is the first report that demonstrates selective inactivation of ERalpha isoforms through the promoter CpG methylation pathway in leukaemias."
],
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[
97,
255
]
]
}
] |
[
{
"id": "DS.d1277.s0.e0",
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],
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55,
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"db_id": "6804"
}
]
},
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"id": "DS.d1277.s0.e1",
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],
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]
}
] |
[] |
[] |
[
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}
] |
DS.d1282
|
18809364
|
[
{
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"type": "",
"text": [
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],
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[
0,
317
]
]
}
] |
[
{
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70,
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},
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]
}
] |
[] |
[] |
[] |
DS.d1283
|
18809367
|
[
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"type": "",
"text": [
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167,
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],
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]
}
] |
[] |
[] |
[
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}
] |
DS.d1284
|
18809432
|
[
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"type": "",
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]
}
] |
[
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] |
[] |
[] |
[
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}
] |
DS.d1285
|
18809481
|
[
{
"id": "DS.d1285.s0",
"type": "",
"text": [
"Effect of polyols on the solubility of bovine serum albumin (BSA) in the presence of polyethylene glycols (PEGs) was investigated in order to strengthen the understanding of the observed effects of polyols and PEGs on protein properties in solution."
],
"offsets": [
[
0,
249
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]
}
] |
[
{
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]
},
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85,
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],
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}
]
}
] |
[] |
[] |
[] |
DS.d1286
|
18810331
|
[
{
"id": "DS.d1286.s0",
"type": "",
"text": [
"After 2 and 6 weeks of treatment, parotid gland was removed and total protein and sialic acid (free and total) concentration and amylase and peroxidase activities were determined."
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0,
179
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]
},
{
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"type": "",
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[
180,
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]
}
] |
[
{
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82,
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},
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}
]
}
] |
[] |
[] |
[] |
DS.d1287
|
18810466
|
[
{
"id": "DS.d1287.s0",
"type": "",
"text": [
"To investigate the change pattern of substance P (SP) and nitric oxide (NO) in the portal vein during the recto-anal inhibitory reflex (RAIR), and its physiological significance; the influence of external splanchnic nerve (ESN) of rectum and anus to the RAIR."
],
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0,
259
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]
}
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[
{
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"db_id": "P67933"
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]
},
{
"id": "DS.d1287.s0.e1",
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58,
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],
"normalized": [
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}
]
}
] |
[] |
[] |
[] |
DS.d1288
|
18810510
|
[
{
"id": "DS.d1288.s0",
"type": "",
"text": [
"Considering the common metabolic pathway and synergism between dopamine and serotonin, the role of dopamine transporter (SLC6A3, DAT) and monoamine oxidase A (MAOA) genes in SIDS and stillbirth (sudden intrauterine unexplained death, SIUD) was investigated."
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[
0,
257
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]
}
] |
[
{
"id": "DS.d1288.s0.e0",
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76,
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}
]
},
{
"id": "DS.d1288.s0.e1",
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"text": [
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],
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},
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"db_id": "Q61327"
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"db_id": "Q9GJT6"
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]
},
{
"id": "DS.d1288.s0.e3",
"type": "protein",
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138,
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],
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"db_id": "P49253"
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]
},
{
"id": "DS.d1288.s0.e4",
"type": "protein",
"text": [
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{
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"db_id": "Q6Q2J0"
}
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}
] |
[] |
[] |
[] |
DS.d1289
|
18810517
|
[
{
"id": "DS.d1289.s0",
"type": "",
"text": [
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],
"offsets": [
[
0,
166
]
]
}
] |
[
{
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2,
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],
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},
{
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{
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{
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]
}
] |
[] |
[] |
[] |
DS.d1290
|
18810712
|
[
{
"id": "DS.d1290.s0",
"type": "",
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"DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured."
],
"offsets": [
[
0,
217
]
]
}
] |
[
{
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],
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6,
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]
},
{
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],
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14,
33
]
],
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]
},
{
"id": "DS.d1290.s0.e2",
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},
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},
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],
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104,
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]
],
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]
},
{
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113,
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}
]
},
{
"id": "DS.d1290.s0.e6",
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"text": [
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],
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124,
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],
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},
{
"id": "DS.d1290.s0.e7",
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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{
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]
},
{
"id": "DS.d1290.s0.e8",
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],
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143,
148
]
],
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]
},
{
"id": "DS.d1290.s0.e9",
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150,
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],
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},
{
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},
{
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},
{
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},
{
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]
},
{
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},
{
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}
]
}
] |
[] |
[] |
[] |
DS.d1291
|
18812013
|
[
{
"id": "DS.d1291.s0",
"type": "",
"text": [
"Our data indicate that genetic differences in S100B gene expression may predispose individual differences in the responsivity to repeated intake of MDMA."
],
"offsets": [
[
0,
153
]
]
}
] |
[
{
"id": "DS.d1291.s0.e0",
"type": "protein",
"text": [
"S100B"
],
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[
46,
51
]
],
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},
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},
{
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"db_id": "Q6YNR6"
}
]
},
{
"id": "DS.d1291.s0.e1",
"type": "compound",
"text": [
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],
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148,
152
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "1615"
}
]
}
] |
[] |
[] |
[
{
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"type": "compound-protein-interaction",
"arg1_id": "DS.d1291.s0.e1",
"arg2_id": "DS.d1291.s0.e0",
"normalized": []
}
] |
DS.d1292
|
18812209
|
[
{
"id": "DS.d1292.s0",
"type": "",
"text": [
"Angiotensin II (Ang II) is the key peptide hormone in the renin-angiotensin-aldosterone system (RAAS)."
],
"offsets": [
[
0,
102
]
]
}
] |
[
{
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0,
14
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],
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]
},
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}
]
},
{
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]
},
{
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],
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}
]
},
{
"id": "DS.d1292.s0.e4",
"type": "compound",
"text": [
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],
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76,
87
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "5839"
}
]
}
] |
[] |
[] |
[
{
"id": "DS.d1292.s0.i0",
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"arg1_id": "DS.d1292.s0.e4",
"arg2_id": "DS.d1292.s0.e1",
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},
{
"id": "DS.d1292.s0.i2",
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"normalized": []
}
] |
DS.d1293
|
18812225
|
[
{
"id": "DS.d1293.s0",
"type": "",
"text": [
"The enzyme responsible for D-serine biosynthesis, serine racemase (SR), is therefore a promising target for treatment of neuropathologies related to glutamate receptor excitotoxicity, such as stroke or Alzheimer's disease."
],
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[
0,
222
]
]
}
] |
[
{
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],
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29,
35
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],
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"db_id": "5951"
}
]
},
{
"id": "DS.d1293.s0.e1",
"type": "protein",
"text": [
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],
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[
50,
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],
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"db_id": "Q9GZT4"
},
{
"db_name": "UniProt",
"db_id": "Q9QZX7"
}
]
}
] |
[] |
[] |
[
{
"id": "DS.d1293.s0.i0",
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"arg1_id": "DS.d1293.s0.e0",
"arg2_id": "DS.d1293.s0.e1",
"normalized": []
}
] |
DS.d1294
|
18812229
|
[
{
"id": "DS.d1294.s0",
"type": "",
"text": [
"Hepatocyte apoptosis was estimated morphologically using Annexin-V combined with propidium iodide, or toluidine blue staining."
],
"offsets": [
[
0,
126
]
]
}
] |
[
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{
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"db_id": "Q5R1W0"
}
]
},
{
"id": "DS.d1294.s0.e1",
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],
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]
},
{
"id": "DS.d1294.s0.e2",
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102,
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],
"normalized": [
{
"db_name": "PubChem",
"db_id": "7084"
}
]
}
] |
[] |
[] |
[] |
DS.d1295
|
18812233
|
[
{
"id": "DS.d1295.s0",
"type": "",
"text": [
"To investigate the metabolism of NADA through the cytochrome P450 (CYP450) metabolic pathway, we studied the in vitro rat liver microsomal production of hydroxylated metabolites and their activity at recombinant human TRPV(1) receptors."
],
"offsets": [
[
0,
236
]
]
}
] |
[
{
"id": "DS.d1295.s0.e0",
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33,
37
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],
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"db_id": "5282105"
}
]
},
{
"id": "DS.d1295.s0.e1",
"type": "protein",
"text": [
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],
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50,
65
]
],
"normalized": [
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"db_name": "UniProt",
"db_id": "O08469"
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]
}
] |
[] |
[] |
[
{
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"arg1_id": "DS.d1295.s0.e0",
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}
] |
DS.d1296
|
18812596
|
[
{
"id": "DS.d1296.s0",
"type": "",
"text": [
"The FFA fractions elicited pro-inflammatory responses inducing TNFalpha and intracellular adhesion molecule expression and reactive oxygen species (ROS) production in human aortic endothelial cells (HAECs)."
],
"offsets": [
[
0,
206
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]
}
] |
[
{
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],
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63,
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],
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]
}
] |
[] |
[] |
[] |
DS.d1297
|
18812689
|
[
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"id": "DS.d1297.s0",
"type": "",
"text": [
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],
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[] |
[] |
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] |
DS.d1298
|
18814142
|
[
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] |
[] |
[] |
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] |
DS.d1299
|
18814181
|
[
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"id": "DS.d1299.s0",
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] |
[] |
[] |
[
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}
] |
DS.d1300
|
18814266
|
[
{
"id": "DS.d1300.s0",
"type": "",
"text": [
"However, lovastatin treatment resulted in intracellular accumulation of PLP and prevented its translocation to the cell surface."
],
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[
0,
128
]
]
}
] |
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}
] |
[] |
[] |
[
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}
] |
DS.d1301
|
18814279
|
[
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"id": "DS.d1301.s0",
"type": "",
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0,
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}
] |
[
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0,
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},
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},
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],
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] |
[] |
[] |
[
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}
] |
DS.d1302
|
18814300
|
[
{
"id": "DS.d1302.s0",
"type": "",
"text": [
"The large and diverse family of cytochrome P450 monooxygenases (CYPs) was systematically analyzed to identify selectivity- and specificity-determining residues in the substrate recognition site 5, which is located in close vicinity to the heme center."
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]
},
{
"id": "DS.d1302.s1",
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],
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252,
417
]
]
}
] |
[
{
"id": "DS.d1302.s0.e0",
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32,
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},
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"id": "DS.d1302.s0.e1",
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[] |
[] |
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DS.d1303
|
18814316
|
[
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[] |
[] |
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] |
DS.d1304
|
18814864
|
[
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"type": "",
"text": [
"A number of site-specific modifications of the nucleosome core histones-including the trimethylated forms of histone H3 lysines K4, K9, and K27-are of particular interest for postmortem research, because these marks differentiate between active and inactive chromatin and seem to remain relatively stable during tissue autolysis."
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[] |
[] |
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}
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DS.d1305
|
18814910
|
[
{
"id": "DS.d1305.s0",
"type": "",
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0,
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]
},
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],
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[
126,
326
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]
}
] |
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25,
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},
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}
] |
[] |
[] |
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] |
DS.d1306
|
18814934
|
[
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"id": "DS.d1306.s0",
"type": "",
"text": [
"To verify the possible involvement of lipids and several other compounds including hydrogen peroxide (H(2)O(2)) and glyceraldehyde-3-phosphate dehydrogenase (G3PDH) in the response of Hordeum vulgare to early potassium deprivation, plants were grown in hydroponic conditions for 30d with a modified Hewitt nutrient solution containing 3mM K(+)."
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] |
[] |
[] |
[] |
DS.d1307
|
18815024
|
[
{
"id": "DS.d1307.s0",
"type": "",
"text": [
"A new biosensor for trehalose determination has been realized by means of a flow system, based on a reactor in which the trehalase enzyme catalyses its hydrolysis into two alpha,d-glucose molecules, and a GOD (glucose oxidase) amperometric biosensor is employed for the glucose determination."
],
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}
] |
[] |
[] |
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}
] |
DS.d1308
|
18815084
|
[
{
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"type": "",
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[] |
[] |
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}
] |
DS.d1309
|
18815123
|
[
{
"id": "DS.d1309.s0",
"type": "",
"text": [
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],
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[
0,
184
]
]
}
] |
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],
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}
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}
] |
[] |
[] |
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}
] |
DS.d1310
|
18815141
|
[
{
"id": "DS.d1310.s0",
"type": "",
"text": [
"Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes."
],
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[
0,
71
]
]
}
] |
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0,
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}
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}
] |
[] |
[] |
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}
] |
DS.d1311
|
18815243
|
[
{
"id": "DS.d1311.s0",
"type": "",
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],
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0,
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]
}
] |
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]
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] |
[] |
[] |
[] |
DS.d1312
|
18815356
|
[
{
"id": "DS.d1312.s0",
"type": "",
"text": [
"Lower expression of IGFBP1 and prolactin mRNA and protein was observed in hESF from women with vs. those without endometriosis in response to 8-Br-cAMP, but not P4, suggesting a blunted response of these decidual biomarkers to activation of the PKA pathway in eutopic endometrium in women with disease."
],
"offsets": [
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0,
302
]
]
}
] |
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20,
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] |
[] |
[] |
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] |
DS.d1313
|
18815358
|
[
{
"id": "DS.d1313.s0",
"type": "",
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],
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0,
186
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]
}
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] |
[] |
[] |
[] |
DS.d1314
|
18815782
|
[
{
"id": "DS.d1314.s0",
"type": "",
"text": [
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],
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0,
148
]
]
}
] |
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69,
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]
],
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}
] |
[] |
[] |
[
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"arg1_id": "DS.d1314.s0.e1",
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}
] |
DS.d1315
|
18815831
|
[
{
"id": "DS.d1315.s0",
"type": "",
"text": [
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]
},
{
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],
"offsets": [
[
132,
290
]
]
}
] |
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18815849
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DS.d1317
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18815869
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DS.d1319
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18815882
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DS.d1320
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DS.d1321
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18816698
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DS.d1322
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18816790
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356,
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}
] |
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{
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}
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}
] |
[] |
[] |
[
{
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}
] |
DS.d1323
|
18817778
|
[
{
"id": "DS.d1323.s0",
"type": "",
"text": [
"The inhibition of female rabbit sexual behavior by progesterone : progesterone receptor-dependent and-independent effects."
],
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0,
122
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]
}
] |
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},
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},
{
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]
}
] |
[] |
[] |
[
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"normalized": []
}
] |
DS.d1324
|
18817795
|
[
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],
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77,
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"text": [
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],
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[
321,
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}
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},
{
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}
]
}
] |
[] |
[] |
[
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}
] |
DS.d1325
|
18817797
|
[
{
"id": "DS.d1325.s0",
"type": "",
"text": [
"The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain."
],
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[
0,
155
]
]
}
] |
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]
},
{
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]
},
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},
{
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}
]
}
] |
[] |
[] |
[] |
DS.d1326
|
18817816
|
[
{
"id": "DS.d1326.s0",
"type": "",
"text": [
"The expressions of serotonin receptors (5-hydroxytryptamine receptor), corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA in the hypothalamus were detected by real time PCR."
],
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[
0,
196
]
]
}
] |
[
{
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19,
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},
{
"db_name": "UniProt",
"db_id": "Q25414"
}
]
},
{
"id": "DS.d1326.s0.e1",
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],
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40,
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}
]
},
{
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],
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}
]
},
{
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104,
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]
},
{
"id": "DS.d1326.s0.e4",
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"text": [
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113,
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],
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{
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}
]
}
] |
[] |
[] |
[] |
DS.d1327
|
18817841
|
[
{
"id": "DS.d1327.s0",
"type": "",
"text": [
"After incubation with 4- androstene-3,17-dione (4-dione), there are no estrogens, estrone (E1) and estradiol (E2), detected suggesting that the pathway of aromatase is not important in these cell lines."
],
"offsets": [
[
0,
202
]
]
}
] |
[
{
"id": "DS.d1327.s0.e0",
"type": "compound",
"text": [
"estrone"
],
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82,
89
]
],
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"db_id": "5870"
}
]
},
{
"id": "DS.d1327.s0.e1",
"type": "compound",
"text": [
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],
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[
99,
108
]
],
"normalized": [
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"db_name": "PubChem",
"db_id": "5757"
}
]
},
{
"id": "DS.d1327.s0.e2",
"type": "protein",
"text": [
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],
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155,
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],
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{
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{
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"db_id": "Q95M61"
},
{
"db_name": "UniProt",
"db_id": "Q9XS28"
}
]
}
] |
[] |
[] |
[] |
DS.d1328
|
18817845
|
[
{
"id": "DS.d1328.s0",
"type": "",
"text": [
"The aim of this study was to investigate the effects of acute and chronic exercise on thiobarbituric acid reactive substances, as an indicator of lipid peroxidation, in the hippocampus, which has a high concentration of glucocorticoid receptors, and prefrontal cortex and striatum, which have high dopamine content."
],
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0,
315
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]
},
{
"id": "DS.d1328.s1",
"type": "",
"text": [
"Additionally we examined antioxidant enzyme activities, superoxide dismutase and glutathione peroxidase and nitrite-nitrate levels to assess the effects of reactive oxygen and nitrogen species."
],
"offsets": [
[
316,
509
]
]
}
] |
[
{
"id": "DS.d1328.s0.e0",
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86,
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],
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]
},
{
"id": "DS.d1328.s0.e1",
"type": "protein",
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],
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220,
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],
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"db_name": "UniProt",
"db_id": "P06536"
},
{
"db_name": "UniProt",
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},
{
"db_name": "UniProt",
"db_id": "P35547"
},
{
"db_name": "UniProt",
"db_id": "P49115"
},
{
"db_name": "UniProt",
"db_id": "P49843"
},
{
"db_name": "UniProt",
"db_id": "P49844"
},
{
"db_name": "UniProt",
"db_id": "P59667"
},
{
"db_name": "UniProt",
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},
{
"db_name": "UniProt",
"db_id": "P79686"
},
{
"db_name": "UniProt",
"db_id": "Q5R9P5"
},
{
"db_name": "UniProt",
"db_id": "Q6XLJ0"
},
{
"db_name": "UniProt",
"db_id": "Q95267"
},
{
"db_name": "UniProt",
"db_id": "Q9N1U3"
}
]
},
{
"id": "DS.d1328.s0.e2",
"type": "compound",
"text": [
"dopamine"
],
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[
298,
306
]
],
"normalized": [
{
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"db_id": "681"
}
]
},
{
"id": "DS.d1328.s1.e0",
"type": "protein",
"text": [
"superoxide dismutase"
],
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[
372,
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]
],
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"db_id": "O50258"
}
]
},
{
"id": "DS.d1328.s1.e1",
"type": "protein",
"text": [
"glutathione peroxidase"
],
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[
397,
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]
],
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]
},
{
"id": "DS.d1328.s1.e2",
"type": "compound",
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],
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432,
439
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "943"
}
]
}
] |
[] |
[] |
[] |
DS.d1329
|
18818063
|
[
{
"id": "DS.d1329.s0",
"type": "",
"text": [
"Oral administration of (PhSe)(2) in rats did not change plasma alanine and aspartate aminotransferase activities (AST and ALT) as well as urea and creatinine levels."
],
"offsets": [
[
0,
165
]
]
}
] |
[
{
"id": "DS.d1329.s0.e0",
"type": "protein",
"text": [
"aspartate aminotransferase"
],
"offsets": [
[
75,
101
]
],
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},
{
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{
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},
{
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},
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{
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{
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},
{
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{
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},
{
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},
{
"db_name": "UniProt",
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},
{
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},
{
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{
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{
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},
{
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},
{
"db_name": "UniProt",
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},
{
"db_name": "UniProt",
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},
{
"db_name": "UniProt",
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},
{
"db_name": "UniProt",
"db_id": "Q9V0L2"
},
{
"db_name": "UniProt",
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},
{
"db_name": "UniProt",
"db_id": "Q9ZE56"
}
]
},
{
"id": "DS.d1329.s0.e1",
"type": "protein",
"text": [
"AST"
],
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114,
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]
],
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{
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{
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{
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},
{
"db_name": "UniProt",
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},
{
"db_name": "UniProt",
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},
{
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},
{
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},
{
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},
{
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"db_id": "Q9NRA2"
},
{
"db_name": "UniProt",
"db_id": "Q9ZC67"
}
]
},
{
"id": "DS.d1329.s0.e2",
"type": "compound",
"text": [
"urea"
],
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[
138,
142
]
],
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{
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"db_id": "1176"
},
{
"db_name": "PubChem",
"db_id": "265993"
}
]
},
{
"id": "DS.d1329.s0.e3",
"type": "compound",
"text": [
"creatinine"
],
"offsets": [
[
147,
157
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "588"
}
]
}
] |
[] |
[] |
[] |
DS.d1330
|
18818229
|
[
{
"id": "DS.d1330.s0",
"type": "",
"text": [
"Total plasma homocysteine level, MTHFR C677T polymorphism, inherited abnormalities of the natural anticoagulant system as well as plasma folate and cobalamin levels were determined."
],
"offsets": [
[
0,
181
]
]
}
] |
[
{
"id": "DS.d1330.s0.e0",
"type": "compound",
"text": [
"homocysteine"
],
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[
13,
25
]
],
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"db_id": "778"
}
]
},
{
"id": "DS.d1330.s0.e1",
"type": "protein",
"text": [
"MTHFR"
],
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[
33,
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]
],
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"db_id": "P42898"
},
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},
{
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"db_id": "Q60HE5"
}
]
},
{
"id": "DS.d1330.s0.e2",
"type": "compound",
"text": [
"folate"
],
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[
137,
143
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "6037"
}
]
},
{
"id": "DS.d1330.s0.e3",
"type": "compound",
"text": [
"cobalamin"
],
"offsets": [
[
148,
157
]
],
"normalized": [
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"db_name": "PubChem",
"db_id": "3034082"
},
{
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"db_id": "6713940"
},
{
"db_name": "PubChem",
"db_id": "25243974"
}
]
}
] |
[] |
[] |
[] |
DS.d1331
|
18818289
|
[
{
"id": "DS.d1331.s0",
"type": "",
"text": [
"Immunohistochemical colabeling for nesfatin-1 and ghrelin, histidine decarboxylase, or somatostatin revealed two subtypes of nesfatin-1-positive endocrine cells."
],
"offsets": [
[
0,
161
]
]
},
{
"id": "DS.d1331.s1",
"type": "",
"text": [
"Cells in the midportion of the glands coexpressed nesfatin-1 and ghrelin, whereas few cells in the glandular base coexpressed nesfatin-1 and somatostatin or histidine decarboxylase."
],
"offsets": [
[
162,
343
]
]
}
] |
[
{
"id": "DS.d1331.s0.e0",
"type": "protein",
"text": [
"ghrelin"
],
"offsets": [
[
50,
57
]
],
"normalized": [
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"db_name": "UniProt",
"db_id": "Q6BEG6"
},
{
"db_name": "UniProt",
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},
{
"db_name": "UniProt",
"db_id": "Q9BDJ6"
},
{
"db_name": "UniProt",
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},
{
"db_name": "UniProt",
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},
{
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},
{
"db_name": "UniProt",
"db_id": "Q9QYH7"
},
{
"db_name": "UniProt",
"db_id": "Q9UBU3"
}
]
},
{
"id": "DS.d1331.s0.e1",
"type": "protein",
"text": [
"histidine decarboxylase"
],
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[
59,
82
]
],
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},
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}
]
},
{
"id": "DS.d1331.s0.e2",
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"text": [
"somatostatin"
],
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87,
99
]
],
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},
{
"db_name": "PubChem",
"db_id": "16129706"
}
]
},
{
"id": "DS.d1331.s1.e0",
"type": "protein",
"text": [
"ghrelin"
],
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227,
234
]
],
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"db_id": "Q6BEG6"
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},
{
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},
{
"db_name": "UniProt",
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},
{
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},
{
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},
{
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"db_id": "Q9UBU3"
}
]
},
{
"id": "DS.d1331.s1.e1",
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],
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303,
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]
],
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},
{
"db_name": "PubChem",
"db_id": "16129706"
}
]
},
{
"id": "DS.d1331.s1.e2",
"type": "protein",
"text": [
"histidine decarboxylase"
],
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[
319,
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]
],
"normalized": [
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"db_id": "P05034"
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},
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},
{
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},
{
"db_name": "UniProt",
"db_id": "P54772"
},
{
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"db_id": "P95477"
},
{
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},
{
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"db_id": "Q8L0Z4"
},
{
"db_name": "UniProt",
"db_id": "Q98A07"
}
]
}
] |
[] |
[] |
[] |
DS.d1332
|
18818294
|
[
{
"id": "DS.d1332.s0",
"type": "",
"text": [
"Importantly, tPA and PAI-1 proteins and tPA activity were low/nondetectable in granulosa cells obtained after treatment with hCG and the PG synthesis inhibitor celecoxib."
],
"offsets": [
[
0,
170
]
]
},
{
"id": "DS.d1332.s1",
"type": "",
"text": [
"To determine whether hCG stimulation of tPA and PAI-1 requires PGE2, granulosa cells obtained at 0 h were cultured with hCG plus indomethacin to inhibit PG production; some cells also received PGE2 or an agonist selective for one PGE2 receptor (EP)."
],
"offsets": [
[
171,
420
]
]
}
] |
[
{
"id": "DS.d1332.s0.e0",
"type": "protein",
"text": [
"tPA"
],
"offsets": [
[
13,
16
]
],
"normalized": [
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"db_id": "P00750"
},
{
"db_name": "UniProt",
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},
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"db_name": "UniProt",
"db_id": "P19637"
},
{
"db_name": "UniProt",
"db_id": "Q28198"
}
]
},
{
"id": "DS.d1332.s0.e1",
"type": "protein",
"text": [
"PAI-1"
],
"offsets": [
[
21,
26
]
],
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"db_name": "UniProt",
"db_id": "P05121"
},
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{
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"db_id": "P20961"
},
{
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},
{
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"db_id": "P50449"
},
{
"db_name": "UniProt",
"db_id": "P79335"
}
]
},
{
"id": "DS.d1332.s0.e2",
"type": "protein",
"text": [
"tPA"
],
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[
40,
43
]
],
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"db_id": "P00750"
},
{
"db_name": "UniProt",
"db_id": "P11214"
},
{
"db_name": "UniProt",
"db_id": "P19637"
},
{
"db_name": "UniProt",
"db_id": "Q28198"
}
]
},
{
"id": "DS.d1332.s0.e3",
"type": "compound",
"text": [
"celecoxib"
],
"offsets": [
[
160,
169
]
],
"normalized": [
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"db_name": "PubChem",
"db_id": "2662"
}
]
},
{
"id": "DS.d1332.s1.e0",
"type": "protein",
"text": [
"tPA"
],
"offsets": [
[
211,
214
]
],
"normalized": [
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"db_id": "P00750"
},
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"db_id": "P19637"
},
{
"db_name": "UniProt",
"db_id": "Q28198"
}
]
},
{
"id": "DS.d1332.s1.e1",
"type": "protein",
"text": [
"PAI-1"
],
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219,
224
]
],
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"db_name": "UniProt",
"db_id": "P05121"
},
{
"db_name": "UniProt",
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},
{
"db_name": "UniProt",
"db_id": "P20961"
},
{
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"db_id": "P22777"
},
{
"db_name": "UniProt",
"db_id": "P50449"
},
{
"db_name": "UniProt",
"db_id": "P79335"
}
]
},
{
"id": "DS.d1332.s1.e2",
"type": "compound",
"text": [
"indomethacin"
],
"offsets": [
[
300,
312
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "3715"
}
]
}
] |
[] |
[] |
[
{
"id": "DS.d1332.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d1332.s0.e3",
"arg2_id": "DS.d1332.s0.e0",
"normalized": []
},
{
"id": "DS.d1332.s0.i1",
"type": "compound-protein-interaction",
"arg1_id": "DS.d1332.s0.e3",
"arg2_id": "DS.d1332.s0.e1",
"normalized": []
}
] |
DS.d1333
|
18818299
|
[
{
"id": "DS.d1333.s0",
"type": "",
"text": [
"The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "DS.d1333.s0.e0",
"type": "compound",
"text": [
"tanshinone IIA"
],
"offsets": [
[
12,
26
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "164676"
}
]
},
{
"id": "DS.d1333.s0.e1",
"type": "protein",
"text": [
"peroxisome proliferator-activated receptor gamma"
],
"offsets": [
[
63,
111
]
],
"normalized": [
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"db_name": "UniProt",
"db_id": "O18924"
},
{
"db_name": "UniProt",
"db_id": "O18971"
},
{
"db_name": "UniProt",
"db_id": "O19052"
},
{
"db_name": "UniProt",
"db_id": "O62807"
},
{
"db_name": "UniProt",
"db_id": "O88275"
},
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"db_name": "UniProt",
"db_id": "P37231"
},
{
"db_name": "UniProt",
"db_id": "P37234"
},
{
"db_name": "UniProt",
"db_id": "P37238"
},
{
"db_name": "UniProt",
"db_id": "P57797"
},
{
"db_name": "UniProt",
"db_id": "Q4U3Q4"
}
]
}
] |
[] |
[] |
[
{
"id": "DS.d1333.s0.i0",
"type": "compound-protein-interaction",
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] |
DS.d1334
|
18818375
|
[
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] |
[] |
[] |
[] |
DS.d1335
|
18818396
|
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] |
[] |
[] |
[
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}
] |
DS.d1336
|
18818486
|
[
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],
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0,
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}
] |
[] |
[] |
[] |
DS.d1337
|
18818687
|
[
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"type": "",
"text": [
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0,
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]
}
] |
[] |
[] |
[] |
DS.d1338
|
18818710
|
[
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"type": "",
"text": [
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],
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320,
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]
}
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]
}
] |
[] |
[] |
[
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}
] |
DS.d1340
|
18818946
|
[
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[] |
[] |
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}
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DS.d1341
|
18819019
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"text": [
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18819053
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DS.d1343
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] |
[] |
[] |
[
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"arg1_id": "DS.d1343.s0.e1",
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"normalized": []
}
] |
DS.d1344
|
18819713
|
[
{
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"type": "",
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] |
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] |
[] |
[] |
[] |
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