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์์ 22์ฃผ์ฐจ์ 23์ธ ์์ฐ๋ถ๊ฐ ๋ฐฐ๋จ ์ ์์ด๊ฐ์ ํธ์ํ๋ฉฐ ๋ด์ํ์ต๋๋ค. ํ์๋ 1์ผ ์ ์ ์ฆ์์ด ์์๋์๊ณ , ๋ฌผ์ ๋ ๋ง์๊ณ ํฌ๋๋ฒ ๋ฆฌ ์ถ์ถ๋ฌผ์ ๋ณต์ฉํ์์๋ ์
ํ๋์๋ค๊ณ ์ง์ ํฉ๋๋ค. ๊ทธ ์ธ์๋ ๊ฑด๊ฐํ๊ฒ ๋๋ผ๊ณ ์์ผ๋ฉฐ, ์์ ๊ด๋ จํ์ฌ ์์ฌ์ ์ง๋ฃ๋ฅผ ๋ฐ๊ณ ์์ต๋๋ค. ์ฒด์จ์ 97.7ยฐF (36.5ยฐC), ํ์์ 122/77 mmHg, ๋งฅ๋ฐ์ 80/min, ํธํก์๋ 19/min, ์ค๋ด ๊ณต๊ธฐ ์ค ์ฐ์ ํฌํ๋๋ 98%์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ๋๊ณจ์ฒ์ถ๊ฐ ์ํต์ ์๊ณ , ์์ ์๊ถ์ด ํ์ธ๋์์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์๊ฒ ๊ฐ์ฅ ์ ํฉํ ์น๋ฃ๋ฒ์ ๋ฌด์์
๋๊น? | Nitrofurantoin | {
"A": "Ampicillin",
"B": "Ceftriaxone",
"C": "Doxycycline",
"D": "Nitrofurantoin"
} | step2&3 | D | [
"23 year old pregnant woman",
"weeks presents",
"burning",
"urination",
"states",
"started 1 day",
"worsening",
"drinking",
"water",
"taking cranberry extract",
"feels well",
"followed by",
"doctor",
"pregnancy",
"temperature",
"97",
"36",
"blood pressure",
"mmHg",
"pulse",
"80 min",
"respirations",
"min",
"oxygen saturation",
"98",
"room air",
"Physical exam",
"notable",
"absence",
"costovertebral angle tenderness",
"gravid uterus",
"following",
"best treatment",
"patient"
] | 00000000000000000000 |
์ํ 3๊ฐ์ ๋ ์๊ธฐ๊ฐ ๋ฐค์ ์ ๋ ๋์ ๊ฐ์๊ธฐ ์ฌ๋งํ์ต๋๋ค. ์๊ธฐ์ ์ด๋จธ๋๋ ์์นจ์ ์ผ์ด๋์์ผ ์๊ธฐ๊ฐ ์ฌ๋งํ ๊ฒ์ ์์์ต๋๋ค. ๋ถ๊ฒ ๊ฒฐ๊ณผ ์ฌ๋ง ์์ธ์ ๋ฐํ์ง์ง ์์์ต๋๋ค. ๋ค์ ์ค ์ด๋ค ์๋ฐฉ ์กฐ์น๊ฐ ์๊ธฐ์ ์ฌ๋ง์ ๋ง์ ์ ์์์๊น์? | Placing the infant in a supine position on a firm mattress while sleeping | {
"A": "์์๋ฅผ ์ ์๋ ๋์ ๋จ๋จํ ๋งคํธ๋ฆฌ์ค ์์ ๋ฐ๋ฏ์ด ๋ํ๋ ๊ฒ",
"B": "์์๋ฅผ ๋ฎ์ด๋๊ณ ๋์ ์ค๋ด ์จ๋๋ฅผ ์ ์งํ๋ ๊ฒ",
"C": "์๋ฉด ์์ธ๋ฅผ ์ ์งํ๊ธฐ ์ํ ์ฅ์น ์ฌ์ฉ",
"D": "์๋ฉด ์ค ๊ณต๊ฐ ์ ๊ผญ์ง ์ฌ์ฉ ๊ธ์ง"
} | step2&3 | A | [
"3 month old baby died",
"night",
"asleep",
"mother",
"died only",
"awoke in",
"morning",
"cause of death",
"based",
"autopsy",
"following precautions",
"prevented",
"death",
"baby"
] | 00000000000000000001 |
์ด๋จธ๋๊ฐ ์ํ 3์ฃผ ๋ ์์์ ์์ ์ต๊ด์ ๋ํด ๊ฑฑ์ ํ์ฌ ์์๊ณผ ์ง๋ฃ์ค์ ์ฐพ์์ต๋๋ค. ์์ด๋ ํฉ๋ณ์ฆ ์์ด ํ์ด๋ฌ์ผ๋ฉฐ ์ง๊ธ๊น์ง ์ด๋ ํ ์ํ์ ๋ฌธ์ ๋ ์์์ต๋๋ค. ๊ทธ๋ฌ๋ ์ง๋ 4์ผ ๋์ ์์ด๋ ๋ณด์ฑ๊ณ , ๋จน์ ๊ฒ์ ๋ชจ๋ ํ ํ๋ฉฐ, ๊ตฌํ ๋ฌผ์ ์๊น์ ๋
ธ๋์์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ์์ด์ ๋ณต๋ถ๊ฐ ์ฝ๊ฐ ํฝ๋ง๋์์ง๋ง ๋ค๋ฅธ ์ด์์ ๋ฐ๊ฒฌ๋์ง ์์์ต๋๋ค. ๋ค์ ์ค ์ด๋ค ๋ฐฐ์ ๋ฐ์ ์ค๋ฅ๊ฐ ์ด๋ฌํ ์ฆ์์ ์ค๋ช
ํ ์ ์์ต๋๊น? | Abnormal migration of ventral pancreatic bud | {
"A": "๋ณต์ธก ์ท์ฅ ์น์ ๋น์ ์์ ์ธ ์ด๋",
"B": "๊ทผ์ ์ญ์ด์ง์ฅ์ ์์ ํ ์ฌ๊ฐํต ์คํจ",
"C": "์ ๋ฌธ๋ถ์ ๋น์ ์์ ์ธ ๋น๋",
"D": "์ธก๋ฉด ์ฒด๋ฒฝ์ด ๋ณต์ธก์ผ๋ก ์ด๋ํ์ฌ ์ ์ค์ ์์ ์ตํฉ ์คํจ"
} | step1 | A | [
"mother",
"week old infant",
"pediatrician's office",
"concerned",
"feeding habits",
"born",
"complications",
"not",
"medical problems",
"time",
"past",
"days",
"fussy",
"regurgitating",
"feeds",
"vomit",
"yellow",
"color",
"physical exam",
"child's abdomen",
"distended",
"abnormalities",
"following embryologic errors",
"account",
"presentation"
] | 00000000000000000002 |
58์ธ ์ฌ์ฑ์ ๊ธ์ฑ ์ ์ฐ์์ฑ ํธํก ๋ถ์ ์ผ๋ก ์ฌ๋งํ ํ ๋ถ๊ฒ ํ๋ณธ์ ๊ฒ์ฌํ์ต๋๋ค. ๊ทธ๋
๋ 3๊ฐ์ ์ ์ ๋ํด๊ณจ ๊ณจ์ ์์ ์ ๋ฐ์์ต๋๋ค. ์ด๊ธฐ ์
์ ๊ฒฝ๊ณผ๋ ํฉ๋ณ์ฆ์ด ์์๊ณ , ๊ฑด๊ฐํ ์ํ๋ก ์ฌํ ์์ค๋ก ํด์ํ์ต๋๋ค. ์ฌํ ํ ํด์ ์งํ ๊ฐ์์ค๋ฌ์ด ํธํก ๊ณค๋์ ๊ฒช์๊ณ ์ฌ์ ์ง๊ฐ ๋ฐ์ํ์ต๋๋ค. ์์์ ์ ์คํจํ์ต๋๋ค. ํ ์กฐ์ง์ ์กฐ์งํ์ ๊ฒ์ฌ์์ ํ๋๋งฅ ๋ด๊ฐ ์ฃผ๋ณ์ ์ฌ์ ์ฑ ๊ฒฐํฉ ์กฐ์ง์ด ๊ด์ฐฐ๋ฉ๋๋ค. ๋ค์ ์ค ํ์ฌ ์๊ฒฌ์ ๋ํ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ๋ฐ๋ณ ๊ธฐ์ ์ ๋ฌด์์
๋๊น? | Thromboembolism | {
"A": "Thromboembolism",
"B": "Pulmonary ischemia",
"C": "Pulmonary hypertension",
"D": "Pulmonary passive congestion"
} | step1 | A | [
"pulmonary autopsy specimen",
"58 year old woman",
"died",
"acute hypoxic respiratory failure",
"examined",
"recently",
"surgery",
"fractured femur 3 months",
"Initial hospital course",
"uncomplicated",
"discharged",
"rehab facility",
"good health",
"discharge home",
"rehab",
"sudden shortness of breath",
"cardiac",
"Resuscitation",
"unsuccessful",
"histological examination",
"lung tissue",
"fibrous connective tissue",
"lumen of",
"pulmonary artery",
"observed",
"following",
"most likely pathogenesis",
"present findings"
] | 00000000000000000003 |
20์ธ ์ฌ์ฑ ํ์๊ฐ ์ง๋ ์๋
๊ฐ ์๊ฒฝ ๊ณผ๋ค์ฆ์ ๋ณด์ด๋ฉฐ ๋ด์ํ์ต๋๋ค. ํ์๋ ์์ ์ ์๊ฒฝ์ด "ํญ์ ์์ด ๋ง์๋ค"๊ณ ๋งํ๋ฉฐ, ๊ธฐ์ตํ๊ธฐ ์์ํ ์ดํ๋ถํฐ ๋ฉ์ด ์ฝ๊ฒ ๋๋ ์ฆ์์ ๊ฒช์๋ค๊ณ ํฉ๋๋ค. ๊ฐ์กฑ๋ ฅ์ ์ด๋จธ๋๊ฐ ๋ฉ์ด ์ฝ๊ฒ ๋๋ ์ ์ฌํ ๋ฌธ์ ๋ฅผ ๊ฒช์๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ํ์์ ํ๋ ฅ ์งํ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค: ์ฌ๋ฐ์ 98ํ/๋ถ, ํธํก์ 14ํ/๋ถ, ์ฒด์จ 36.1ยฐC (96.9ยฐF), ํ์ 110/87 mm Hg. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ํน์ด ์ฌํญ์ด ์์ต๋๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค: ํ์ํ ์ 200,000/mm3, PT 12์ด, PTT 43์ด. ์ด ํ์์ ์ฆ์์ ๊ฐ์ฅ ์ ๋ ฅํ ์์ธ์ ๋ฌด์์
๋๊น? | Von Willebrand disease | {
"A": "ํ์ฐ๋ณ A",
"B": "๋ฃจํธ์ค ํญ์๊ณ ์ธ์",
"C": "๋จ๋ฐฑ์ง C ๊ฒฐํ",
"D": "ํฐ ๋น๋ ๋ธ๋ํธ๋ณ"
} | step1 | D | [
"20 year old woman presents",
"menorrhagia",
"past",
"years",
"menses",
"always",
"heavy",
"easy bruising",
"long",
"remember",
"Family history",
"significant",
"mother",
"similar problems",
"bruising easily",
"patient's vital signs include",
"heart rate 98 min",
"respiratory rate",
"min",
"temperature 36",
"96 9F",
"blood pressure",
"87 mm Hg",
"Physical examination",
"unremarkable",
"Laboratory tests show",
"following",
"platelet count 200",
"mm3",
"PT",
"seconds",
"PTT",
"seconds",
"following",
"most likely cause",
"patients symptoms"
] | 00000000000000000004 |
40์ธ์ ๋๋ฌผ์ ์ฌ์ก์ฌ๊ฐ ์ฌํ ๋ณตํต์ ํธ์ํ๋ฉฐ ์๊ธ์ค์ ๋ด์ํ์์ผ๋ฉฐ, ํต์ฆ์ ๋ฑ์ชฝ์ผ๋ก ๋ฐฉ์ฌ๋๊ณ ๋ฉ์ค๊บผ์์ด ๋๋ฐ๋ฉ๋๋ค. ํต์ฆ์ 2์ผ ์ ์ ์์๋์์ผ๋ฉฐ, ๋ ์ด์ ์ฐธ์ ์ ์์ ๋๊น์ง ์์ํ ์ฆ๊ฐํ์ต๋๋ค. ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ผ๋ก ๊ณ ํ์๊ณผ ๊ฐ์์ ๊ธฐ๋ฅ ์ ํ์ฆ์ด ์์ต๋๋ค. ๋ํ, ์ต๊ทผ์ ๋๋ฌผ์์ ์์ ์ ๊ฐ์ ์์์ง๋ง ์น๋ฃ๋ฅผ ๋ฐ์ง ์์๋ค๊ณ ํฉ๋๋ค. ๋งค์ผ ์์คํผ๋ฆฐ, ๋ ๋ณดํฐ๋ก์ , ๊ฒฝ๊ตฌ ํผ์์ฝ, ์ข
ํฉ ๋นํ๋ฏผ์ ๋ฅผ ๋ณต์ฉํฉ๋๋ค. ๊ฐ์กฑ๋ ฅ์ ํน์ด์ฌํญ์ด ์์ต๋๋ค. ๊ธ์ผ ํ์์ 108/58 mm Hg, ์ฌ๋ฐ์๋ 99ํ/๋ถ, ํธํก์๋ 21ํ/๋ถ, ์ฒด์จ์ 37.0ยฐC (98.6ยฐF)์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ํ์๋ ๊ฑด๊ฐ์ด ์ข์ง ์์ ๋ณด์ด๋ ์ ๋ฐ๋ฌ๋ ๋น๋ง ์ฌ์ฑ์
๋๋ค. ์ฌ์ฅ์ ๊ท์น์ ์ธ ๋ฐ๋์์ ๋ฆฌ๋ฌ์ ๊ฐ์ง๊ณ ์์ต๋๋ค. ์๊ณจ ๋งฅ๋ฐ์ ์ฝํ์ง๋ง ๋์นญ์ ์
๋๋ค. ํ๋ ์์ชฝ ์ฒญ์ง์ ๊นจ๋ํฉ๋๋ค. ์ผ์ชฝ ์ธ์ธก ๋ฐ๋ชฉ์ ๋ถ์ด ์๊ณ , ํ๋ฐ์ด ์์ผ๋ฉฐ, ๋ง์ก์ ๋ ํต์ฆ์ด ์์ต๋๋ค. ๋ณต๋ถ CT๋ ๊ธ์ฑ ์ท์ฅ์ผ๊ณผ ์ผ์นํฉ๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์ง๋ณ์ ๋ํ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ๋ณ์ธ์ ๋ฌด์์
๋๊น? | Scorpion sting | {
"A": "Aspirin",
"B": "Oral contraceptive pills",
"C": "Scorpion sting",
"D": "Hypothyroidism"
} | step1 | C | [
"40 year old",
"presents",
"emergency department",
"severe abdominal",
"radiates",
"back",
"nausea",
"pain started 2 days",
"slowly increased",
"not",
"longer",
"Past medical history",
"significant",
"hypertension",
"hypothyroidism",
"reports",
"recently stung",
"one",
"smaller scorpions",
"not",
"medical treatment",
"takes aspirin",
"levothyroxine",
"oral contraceptive pills",
"multivitamin daily",
"Family history",
"Today",
"blood pressure",
"58 mm Hg",
"heart rate",
"99 min",
"respiratory rate",
"min",
"temperature",
"98",
"physical exam",
"well",
"obese female",
"looks unwell",
"heart",
"regular rate",
"rhythm",
"Radial pulses",
"weak",
"symmetric",
"lungs",
"clear",
"auscultation",
"lateral",
"swollen",
"erythematous",
"painful to palpate",
"abdominal CT",
"consistent with acute pancreatitis",
"following",
"most likely etiology",
"patients disease"
] | 00000000000000000005 |
25์ธ์ ์ด์๋ถ๊ฐ ์ ๊ธฐ์ ์ธ ์ฐ์ ์ง์ฐฐ์ ์ํด ๋ด๋น ์์ฌ์๊ฒ ๋ด์ํ์ต๋๋ค. ๊ทธ๋
๋ ์ด์ํ ๊ฒ์ฌ๋ก ํ์ธ๋ ๋ฐ์ ๊ฐ์ด ์์ 34์ฃผ์
๋๋ค. ํน๋ณํ ๋ถํธํจ์ ์์ง๋ง, 2์ฃผ ์ ์ ์๋ก ์ฐ ์ ๋ฐ์ด ๋ ์ด์ ๋ง์ง ์๋๋ค๊ณ ํฉ๋๋ค. ๊ทธ๋
์ ์์ ๊ฒฝ๊ณผ๋ ์์กฐ๋ก์ ๊ณ , ๊ถ์ฅ๋๋ ์ฐ์ ๊ด๋ฆฌ๋ฅผ ์ ๋ฐ๋์ต๋๋ค. ๊ทธ๋
์ ๋ณ๋ ฅ์ ํน์ด์ฌํญ์ด ์์ต๋๋ค. 3์ฃผ ์ ๋ง์ง๋ง ๋ฐฉ๋ฌธ ์ดํ๋ก 15ํ์ด๋์ ์ฒด์ค ์ฆ๊ฐ๊ฐ ์์์ต๋๋ค. ๊ทธ๋
์ ํ๋ ฅ ์งํ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค: ํ์, 148/90 mm Hg; ์ฌ๋ฐ์, 88/๋ถ; ํธํก์, 16/๋ถ; ์ฒด์จ, 36.6โ (97.9โ). 4์๊ฐ ํ ๋ฐ๋ณต ์ธก์ ๋ ํ์์ 151/90 mm Hg์
๋๋ค. ํ์ ์ฌ๋ฐ์๋ 151/๋ถ์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ํ์ง์ 2+ ํจ์ ๋ถ์ข
์ด ๋๋๋ฌ์ง๋๋ค. ๋ค์ ์ค ์ด๋ค ๊ฒ์ฌ๊ฐ ์ด ํ์์ ์์๋๋ ์ํ๋ฅผ ํ์ธํด์ผ ํ ๊น์? | 24-hour urine protein | {
"A": "Bilirubin assessment",
"B": "Coagulation studies",
"C": "Leukocyte count with differential",
"D": "24-hour urine protein"
} | step2&3 | D | [
"year old primigravida presents",
"physician",
"routine prenatal visit",
"weeks gestation",
"confirmed by",
"ultrasound examination",
"complaints",
"notes",
"new shoes",
"bought 2 weeks",
"not fit",
"course",
"pregnancy",
"compliant",
"recommended prenatal care",
"medical history",
"unremarkable",
"pound weight gain",
"last visit",
"weeks",
"vital signs",
"follows",
"blood pressure",
"90 mm Hg",
"heart rate",
"88 min",
"respiratory rate",
"min",
"temperature",
"36",
"97",
"blood",
"repeat assessment",
"hours later",
"90 mm Hg",
"fetal heart rate",
"min",
"physical examination",
"significant",
"pitting edema",
"lower extremity",
"following tests",
"confirm",
"probable condition",
"patient"
] | 00000000000000000006 |
3900g (8.6lb)์ ๋จ์ ์ ์์๊ฐ ์์ฐ ๋ถ๋ง์ผ๋ก ์์ 39์ฃผ์ ๋ถ๋ง๋์์ต๋๋ค. ์์ ๊ณผ ๋ถ๋ง์ ํฉ๋ณ์ฆ์ด ์์์ง๋ง, ์์ 20์ฃผ์ฐจ ์ฐ์ ์ด์ํ์์ ํ๋ง๋ณต๋ง ๋ง์ ๊ฒฐํจ์ด ๋ฐ๊ฒฌ๋์์ต๋๋ค. ์ด ํ์์ ๋ํ ์ถ๊ฐ ํ๊ฐ๋ ๋ค์ ์ค ์ด๋ค ์๊ฒฌ์ ๋ณด์ผ ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ๋์ต๋๊น? | Gastric fundus in the thorax | {
"A": "Gastric fundus in the thorax",
"B": "Pancreatic ring around the duodenum",
"C": "Hypertrophy of the gastric pylorus",
"D": "Large bowel in the inguinal canal"
} | step1 | A | [
"male infant",
"delivered",
"weeks",
"gestation",
"spontaneous vaginal delivery",
"Pregnancy",
"delivery",
"uncomplicated",
"prenatal ultrasound",
"20 weeks showed",
"defect",
"pleuroperitoneal membrane",
"Further evaluation",
"patient",
"most likely to show",
"following findings"
] | 00000000000000000007 |
62์ธ ์ฌ์ฑ ํ์๊ฐ ์ ๊ธฐ ๊ฒ์ง์ ์ํด ๋ด์ํ์ต๋๋ค. ํ์๋ ๊ฐํ์ ์ผ๋ก ๋ฐ์ํ๋ ์ด์ง๋ผ์ฆ๊ณผ ์ฌ๊ณํญ์ง์ ํธ์ํฉ๋๋ค. ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ผ๋ก๋ 6๊ฐ์ ์ ์ ์ฌ๊ทผ๊ฒฝ์๊ณผ NYHA class II ๋ง์ฑ ์ฌ๋ถ์ ์ด ์์ต๋๋ค. ๋ํ, 4๋
์ ์ grade I ๋๋งฅ์ฑ ๊ณ ํ์ ์ง๋จ์ ๋ฐ์์ต๋๋ค. ํ์ฌ ๋ณต์ฉ ์ค์ธ ์ฝ๋ฌผ์ ์์คํผ๋ฆฐ 81 mg, ์ํ ๋ฅด๋ฐ์คํํด 10 mg, ์๋ ๋ผํ๋ฆด 10 mg, ๋ฉํ ํ๋กค๋กค 200 mg (๋งค์ผ)์
๋๋ค. ํ๋ ฅ ์งํ๋ ํ์ 135/90 mm Hg, ์ฌ๋ฐ์ 125/min, ํธํก์ 14/min, ์ฒด์จ 36.5ยฐC (97.7ยฐF)์
๋๋ค. ์ฌํ ๊ฒ์ฌ์์ ๋ถ๊ท์นํ ์ฌ๋ฐ ๋ฆฌ๋ฌ๊ณผ ๊ฐ์๋ S1 ๊ฐ๋๊ฐ ๊ด์ฐฐ๋์์ต๋๋ค. ์ฌ์ ๋ ๊ฒ์ฌ๋ฅผ ์ํํ์์ผ๋ฉฐ, ์ฌ์ง์ ์ ์๋์ด ์์ต๋๋ค (์ด๋ฏธ์ง ์ฐธ์กฐ). ์ฌ์ด์ํ ๊ฒ์ฌ์์ ์ข์ฌ์ค ๋ฐ์ถ๋ฅ ์ 39%์
๋๋ค. ๋ค์ ์ฝ๋ฌผ ์ค ์ด ํ์์๊ฒ ์ฌ๋ฐ์ ์กฐ์ ์ ์ํด ๊ฐ์ฅ ์ ํฉํ ์ฝ๋ฌผ์ ๋ฌด์์
๋๊น? | Digoxin | {
"A": "Atenolol",
"B": "Diltiazem",
"C": "Propafenone",
"D": "Digoxin"
} | step1 | D | [
"62 year old woman presents",
"regular check-up",
"lightheadedness",
"palpitations",
"occur",
"Past medical history",
"significant",
"myocardial infarction",
"months",
"NYHA class II chronic heart failure",
"diagnosed",
"grade I arterial hypertension 4",
"Current medications",
"aspirin 81 mg",
"atorvastatin 10 mg",
"enalapril 10 mg",
"metoprolol 200 mg daily",
"vital signs",
"blood pressure",
"90 mm Hg",
"heart rate",
"min",
"respiratory rate",
"min",
"temperature",
"36",
"97",
"Cardiopulmonary examination",
"significant",
"irregular heart rhythm",
"decreased S1 intensity",
"ECG",
"obtained",
"shown",
"picture",
"see image",
"Echocardiography shows",
"left ventricular ejection fraction",
"following drugs",
"best choice",
"rate control",
"patient"
] | 00000000000000000008 |
35์ธ ๋จ์ฑ์ด ๊ณ์ ์ฑ ์๋ ๋ฅด๊ธฐ๋ฅผ ์ฃผ์๋ก ์ฃผ์น์๋ฅผ ๋ฐฉ๋ฌธํ์ต๋๋ค. ๊ทธ๋ ์ ์ฃผ ๋์ 1์ผ ์ ํ ๋น๊ฐ ๋ด ํ๊ด ์์ถ์ ๋ฅผ ์ฌ์ฉํด ์์ต๋๋ค. ๊ตญ์ ๋น๊ฐ ์ถฉํ ์ํ์ ์ ๋ง์ฑ์ ์ธ ์ฌ์ฉ์ ๊ฐ๋ฅํ ํ์ ์ฆ์ ๋ฌด์์
๋๊น? | Persistent congestion | {
"A": "์ฝํผ",
"B": "์๊ตฌ์ ์ธ ํ๊ฐ ์์ค",
"C": "์ง์์ ์ธ ๋น๊ฐ ๊ฐํผ",
"D": "์ง์์ ์ธ ์ฝ๋งํ"
} | step1 | D | [
"35 year old male presents",
"primary care physician",
"complaints",
"seasonal allergies",
"using intranasal vasoconstrictors",
"times per day",
"several weeks",
"likely sequela of",
"chronic use",
"topical nasal decongestants"
] | 00000000000000000009 |
46์ธ ์ฌ์ฑ์ด ์ ๋ฌธ์ ์ฝ์ ๋ 2์ฃผ๊ฐ ์ง์๋ ๋ณต์ ๋ฐ ์๊ตฌ ํต์ฆ์ผ๋ก ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ๊ทธ๋
๋ ๋ํ 3๊ฐ์ ๋์ ๋ฌด์๊ฒฝ, ์๋ฉด ํ์กฐ, ๋ฐํ ์ฆ๊ฐ์ ๋ณ๋ ฅ์ ๊ฐ์ง๊ณ ์์ต๋๋ค. ๊ทธ๋
๋ ์ฑ์ธ๊ธฐ ๋ด๋ด ๊ณผ์ฒด์ค์ด์์ผ๋ฉฐ ์ง๋ 2๊ฐ์ ๋์ 6.8kg(15lb)์ ์ฒด์ค ๊ฐ๋์ ํ ๊ฒ์ ๋ง์กฑํ๋ค๊ณ ๋ณด๊ณ ํฉ๋๋ค. ๊ทธ๋
์ ๋งฅ๋ฐ์ 110ํ/๋ถ์ด๊ณ ํ์์ 148/98 mmHg์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ์๋ฐ๋ฅ์ด ์ถ์ถํ๊ณ ์ํต์ด ์๋ ๊ฐ์์ ์ด ์ ์ ํฌ๊ธฐ์ ๋ ๋ฐฐ๋ก ์ปค์ ธ ์์ต๋๋ค. ์๊ณผ ๊ฒ์ฌ ๊ฒฐ๊ณผ ์๊ตฌ ๋์ถ, ์์ธก ๋๊บผํ ํด์ถ, ๊ฒฐ๋ง ์ถฉํ, ๋์ ์๋ ด ๋ถ๋ฅ์ด ๋ํ๋ฌ์ต๋๋ค. ์ธ์๊ทผ ์ด๋ ์ ํต์ฆ์ ์์ต๋๋ค. ์๋ ฅ์ ์์ชฝ ๋ชจ๋ 20/20์
๋๋ค. ์ ๊ฒฝํ์ ๊ฒ์ฌ ๊ฒฐ๊ณผ ์์ ๋ฏธ์ธํ ์์ ๋จ๋ฆผ์ด ๋ํ๋ฉ๋๋ค. ์ฌ๋ถ๊ฑด ๋ฐ์ฌ๋ 3+์ด๋ฉฐ ์ด์๊ธฐ๊ฐ ๋จ์ถ๋์์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์๊ตฌ ์ฆ์์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ์๋ ์์ธ์ ๋ฌด์์
๋๊น? | Glycosaminoglycan accumulation in the orbit | {
"A": "Cavernous sinus์ ์ก์์ข
์ฑ ์ผ์ฆ",
"B": "Cavernous sinus์ internal carotid artery ์ฌ์ด์ ๋น์ ์์ ์ธ ์ํต",
"C": "Orbit ๋ด Glycosaminoglycan ์ถ์ ",
"D": "Levator palpebrae superioris์ ๊ต๊ฐ ์ ๊ฒฝ ๊ณผ์ ํ๋"
} | step2&3 | C | [
"year old woman",
"physician",
"2-week history",
"diplopia",
"ocular pain",
"reading",
"newspaper",
"3 month history of amenorrhea",
"hot flashes",
"increased sweating",
"reports",
"overweight",
"adult life",
"happy to",
"lost",
"kg",
"weight",
"past",
"months",
"pulse",
"min",
"blood pressure",
"98 mm Hg",
"Physical examination shows moist palms",
"nontender thyroid gland",
"enlarged",
"two times",
"normal size",
"Ophthalmologic examination shows prominence",
"globes",
"eyes",
"bilateral lid retraction",
"conjunctival injection",
"to converge",
"eyes",
"pain",
"movement",
"extraocular muscles",
"Visual acuity",
"20/20",
"Neurologic examination shows",
"fine resting tremor of",
"hands",
"Deep tendon reflexes",
"3",
"shortened relaxation phase",
"following",
"most likely cause",
"patient's ocular complaints"
] | 00000000000000000010 |
1์ธ ๋จ์๊ฐ ์ ์ฝ๊ฐ ๋ฐ ํ๋ ๋ณํ๋ฅผ ์ฃผ์๋ก ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ๋ถ๋ชจ๋ ์ค๋ ์์นจ ์ฒ์ ํ๋ ๋ณํ๋ฅผ ์ธ์งํ์ผ๋ฉฐ, ์ํ๊ฐ ์
ํ๋๊ณ ์๋ค๊ณ ์ง์ ํ์ต๋๋ค. ํ์๊ฐ ์ฒ์์๋ ์์ฒด์ ํ์ ์ ์ฝ ์ฆ์์ ๋ณด์์ง๋ง, ํ์ฌ๋ ๋ค๋ฆฌ๋ฅผ ์์ ๋งํผ์ ํ์ด๋ ํ๋ ฅ์ผ๋ก ์์ง์ด์ง ๋ชปํ๋ค๊ณ ํฉ๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ์์ธก ์๊ฒํ์์ ๋๋ฆฐ ๋๊ณต ๋ฐ์, ๋งค์ฐ ์ฝํ ํก์ฒ ๋ฐ ๊ตฌํ ๋ฐ์ฌ, ์์ ํธํก์ด ๊ด์ฐฐ๋์์ต๋๋ค. ํ์ฌ ํ์๋ ์นจ์ ํ๋ฆฌ๊ณ ์์ผ๋ฉฐ, ๊ธฐ์ ๊ท๋ ๊ฑด์กฐํ ์ํ์
๋๋ค. ๋ถ๋ชจ๋ ํ์๊ฐ 1์ผ ์ด์ ๋ฐฐ๋ณ์ ํ์ง ์์๋ค๊ณ ์ง์ ํฉ๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์ํ ๋ณํ์๋ฆฌ๋ ๋ฌด์์
๋๊น? | Blockade of presynaptic acetylcholine release at the neuromuscular junction | {
"A": "์๋
์ค ์ ์ ์ ๊ฐํ ์นผ์ ์ฑ๋์ ๋ํ ์๊ฐํญ์ฒด",
"B": "๋ง์ด ์ ๊ฒฝ์ ์๊ฐ๋ฉด์ญ ํ์์ดํ",
"C": "์ ๊ฒฝ๊ทผ ์ ํฉ๋ถ์์ ์๋
์ค ์ ์์ธํธ์ฝ๋ฆฐ ๋ฐฉ์ถ ์ฐจ๋จ",
"D": "์ ๊ฐ ๋ด ํ์ ์ด๋ ์ ๊ฒฝ ํ๊ดด"
} | step2&3 | C | [
"year old boy presents",
"emergency department",
"weakness",
"change in",
"behavior",
"parents state",
"first",
"change in",
"behavior",
"morning",
"getting worse",
"patient",
"initially weak",
"upper body",
"arms",
"now",
"move",
"legs",
"strength",
"vigor",
"used to",
"Physical exam",
"notable",
"bilateral ptosis",
"sluggish pupillary response",
"very weak sucking",
"gag reflex",
"shallow respirations",
"patient",
"currently drooling",
"diaper",
"dry",
"parents state",
"not",
"bowel movement",
"1 day",
"following",
"pathophysiology",
"patients condition"
] | 00000000000000000011 |
23์ธ ๋จ์ฑ์ด ์ง๋ 6๊ฐ์ ๋์ ์ฒญ๋ ฅ ๊ฐ์, ํ๊ธฐ์ฆ, ์ค๋ฅธ์ชฝ ๊ท์ ์ด๋ช
์ ๋ํ ํ๊ฐ๋ฅผ ๋ฐ๊ธฐ ์ํด ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ํ, ๊ฐ์ด, ๋ฑ์ ์ฌ๋ฌ ๊ฐ์ ๋ถ๋๋ฝ๊ณ ๋
ธ๋์์ ํ๋ผํฌ์ ๊ตฌ์ง์ด ๊ด์ฐฐ๋ฉ๋๋ค. ๊ฐ๊ฐ์ ๊ฒฝ์ฑ ์ฒญ๋ ฅ ์์ค๊ณผ ์์ชฝ ์๋ฉด ๊ทผ์ก์ ์ ์ฝ์ด ์์ต๋๋ค. ๊ฑธ์๊ฑธ์ด๊ฐ ๋ถ์์ ํฉ๋๋ค. ๋ MRI ๊ฒ์ฌ ๊ฒฐ๊ณผ ์ค๋ฅธ์ชฝ internal auditory meatus ๊ทผ์ฒ์ 3cm ํฌ๊ธฐ์ ์ข
๊ดด์ ์ผ์ชฝ cerebellopontine angle์ 2cm ํฌ๊ธฐ์ ์ข
๊ดด๊ฐ ๋ํ๋ฌ์ต๋๋ค. ์ด๋ฌํ ์ข
๊ดด ๋ด์ ๋น์ ์์ ์ธ ์ธํฌ๋ ๋ค์ ์ค ์ด๋ค ๋ฐฐ์ ๊ตฌ์กฐ์์ ์ ๋ํ์ ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ๋์ต๋๊น? | Neural crest | {
"A": "Neural tube",
"B": "Surface ectoderm",
"C": "Neural crest",
"D": "Notochord"
} | step1 | C | [
"23 year old man",
"physician",
"evaluation",
"decreased hearing",
"dizziness",
"ringing in",
"right ear",
"past 6 months",
"Physical examination shows multiple soft",
"yellow plaques",
"papules",
"arms",
"chest",
"back",
"sensorineural hearing loss",
"weakness",
"facial muscles",
"gait",
"unsteady",
"MRI of",
"brain shows",
"3",
"mass",
"right internal auditory meatus",
"2 cm mass",
"left cerebellopontine angle",
"abnormal cells",
"masses",
"most likely derived",
"following embryological structures"
] | 00000000000000000013 |
62์ธ ์ฌ์ฑ์ด ์ง๋ 2๋
๊ฐ์ ๊ธฐ์นจ๊ณผ ํผ๋ก๋ก ์ธํด ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ์์นจ์๋ ๊ธฐ์นจ์ ํ ๋ ํฐ์ ๊ฐ๋๊ฐ ๋์ต๋๋ค. ๊ณ๋จ์ ์ค๋ฅผ ๋ ์จ์ด ๊ฐ๋น ์ง๋๋ค. ๊ทธ๋
๋ ๊ณ ํ์๊ณผ ๊ณ ์งํ์ฆ์ ์๊ณ ์์ต๋๋ค. ์ต๊ทผ ๋
ธ์์ ์ผํฐ์์ ๊ฐํธ์ฌ๋ก ๊ทผ๋ฌดํ๋ค๊ฐ ์ํดํ์ต๋๋ค. ๊ทธ๋
๋ 40๋
๋์ ๋งค์ผ ๋ด๋ฐฐ 1๊ฐ์ ํผ์ ์ต๋๋ค. ํ์ฌ ๋ณต์ฉ ์ค์ธ ์ฝ๋ฌผ๋ก๋ ramipril๊ณผ fenofibrate๊ฐ ์์ต๋๋ค. ์ฒด์จ์ 36.5ยฐC (97.7ยฐF), ํธํก์๋ 24ํ/๋ถ, ๋งฅ๋ฐ์ 85ํ/๋ถ, ํ์์ 140/90 mm Hg์
๋๋ค. ์์ชฝ ํ์ผ ์ ์ฒด์์ ์ฐ๋ฐ์ ์ธ ์ฒ๋ช
์๊ณผ ๋ฐ์นด์ด๊ฐ ๋ค๋ฆฝ๋๋ค. ์ฌ์ก์, ๋ง์ฐฐ์ ๋๋ ๊ฐค๋ฝ์ ์์ง๋ง ์ฌ์์ ๋ฉ๋ฆฌ์ ๋ค๋ฆฝ๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์ฆ์์ ๊ฐ์ฅ ์ ๋ ฅํ ๊ทผ๋ณธ ์์ธ์ ๋ฌด์์
๋๊น? | Progressive obstruction of expiratory airflow | {
"A": "Chronic decrease in pulmonary compliance",
"B": "Local accumulation of kinins",
"C": "Progressive obstruction of expiratory airflow",
"D": "Incremental loss of functional residual capacity"
} | step2&3 | C | [
"62 year old woman",
"physician",
"coughing",
"fatigue",
"past",
"years",
"morning",
"cough",
"productive",
"white phlegm",
"short of breath walking",
"flight",
"stairs",
"hypertension",
"hyperlipidemia",
"recently retired",
"working",
"nurse",
"homeless shelter",
"smoked 1 pack",
"cigarettes daily",
"40 years",
"Current medications include ramipril",
"fenofibrate",
"temperature",
"36",
"97",
"respirations",
"min",
"pulse",
"85 min",
"blood pressure",
"90 mm Hg",
"Scattered wheezing",
"rhonchi",
"heard",
"lung fields",
"murmurs",
"rubs",
"heart sounds",
"distant",
"following",
"most likely underlying cause",
"patient's symptoms"
] | 00000000000000000014 |
68์ธ ๋จ์ฑ์ด ๋ค๋ฆฌ ํต์ฆ์ผ๋ก ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ๊ทธ๋ ๋ฐ์์ ๊ฑท๋ค๊ฐ ๊ฐ์๊ธฐ ํต์ฆ์ด ์์๋์๋ค๊ณ ๋งํฉ๋๋ค. ํ์๋ ๊ณผ๊ฑฐ ๋น๋จ๋ณ, ๊ณ ํ์, ๋น๋ง, ์ฌ๋ฐฉ์ธ๋ ๋ณ๋ ฅ์ด ์์ต๋๋ค. ์ฒด์จ์ 99.3ยฐF (37.4ยฐC), ํ์์ 152/98 mmHg, ๋งฅ๋ฐ์ 97/min, ํธํก์๋ 15/min, ์ค๋ด ๊ณต๊ธฐ์์ ์ฐ์ ํฌํ๋๋ 99%์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ์ฐจ๊ฐ๊ณ ์ฐฝ๋ฐฑํ ์ผ์ชฝ ๋ค๋ฆฌ๊ฐ ๋๋๋ฌ์ง๋๋ค. ํ์์ ๊ฐ๊ฐ์ ์ค๋ฅธ์ชฝ ๋ค๋ฆฌ์ ๋นํด ์ผ์ชฝ ๋ค๋ฆฌ์์ ํ์ ํ ๊ฐ์๋์๊ณ , ๊ทผ๋ ฅ์ ์ผ์ชฝ ๋ค๋ฆฌ์์ 1/5์
๋๋ค. ๋ค์ ์ค ๊ด๋ฆฌ์์ ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Heparin drip | {
"A": "Graded exercise and aspirin",
"B": "Heparin drip",
"C": "Surgical thrombectomy",
"D": "Tissue plasminogen activator"
} | step2&3 | B | [
"68 year old man presents",
"emergency department",
"leg pain",
"states",
"pain started",
"walking outside",
"patient",
"past medical diabetes",
"hypertension",
"obesity",
"atrial fibrillation",
"temperature",
"99",
"4C",
"blood pressure",
"98 mmHg",
"pulse",
"97 min",
"respirations",
"min",
"oxygen saturation",
"99",
"room air",
"Physical exam",
"notable",
"cold",
"pale left leg",
"patients sensation",
"markedly diminished",
"left leg",
"compared",
"right",
"muscle strength",
"1/5",
"left leg",
"following",
"best next step",
"management"
] | 00000000000000000015 |
76์ธ ํ์ธ ๋จ์ฑ์ด ์ ๋น์ญ์ ์ฃผ์๋ก ์ฃผ์น์์๊ฒ ๋ด์ํ์ต๋๋ค. ๊ทธ๋ ์ด์ ์ ๋ฐค์ ํ ๋ฒ๋ง ๊นจ์ด ์๋ณ์ ๋ณด๋ ๊ฒ๊ณผ ๋ฌ๋ฆฌ, ๋ฐค์ 3~4๋ฒ ์๋ณ์ ๋ณด๊ธฐ ์ํด ์ผ์ด๋ฉ๋๋ค. ๊ทธ๋ ๋ํ ๋ฐฐ๋จ ํ ์ ๋ฐฉ์ธ ๋ฐ ๋ฐฐ๋จ ์์ ์ด๋ ค์์ ํธ์ํฉ๋๋ค. ๊ทธ๋ ๋ฐ๊ธฐ ์ ์ง์ ์ด๋ ค์์ ์๋ค๊ณ ํฉ๋๋ค. ๊ทธ์ ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ ๋น์์ฝ์ฌ์ฑ ์ง๋ฐฉ๊ฐ ์งํ, ๊ณ ํ์, ๊ณ ์งํ์ฆ, ๊ทธ๋ฆฌ๊ณ ํตํ์ด ํน์ง์ ์
๋๋ค. ๊ทธ๋ ์์คํผ๋ฆฐ, ์ํ ๋ฅด๋ฐ์คํํด, ์๋ ๋ผํ๋ฆด, ๊ทธ๋ฆฌ๊ณ ์๋กํธ๋ฆฌ๋์ ๋ณต์ฉํฉ๋๋ค. ๊ทธ์ ๊ฐ์กฑ๋ ฅ์ ๋ถ์น์ ์ ๋ฆฝ์ ์ ๋ฐ ๋ชจ์น์ ํ์์ด ํน์ง์ ์
๋๋ค. ๊ทธ๋ 15 pack-year ํก์ฐ ์ด๋ ฅ์ด ์์ผ๋ฉฐ, ์ฌํ์ ์ผ๋ก ์์ฃผ๋ฅผ ํฉ๋๋ค. ์ง์ฅ ์์ง ๊ฒ์ฌ์ ๊ทธ์ ์ ๋ฆฝ์ ์ ๋น๋ํด์ ธ ์๊ณ , ๋งค๋๋ฌ์ฐ๋ฉฐ, ์ํต์ ์์ต๋๋ค. ๋ค์ ์ฝ๋ฌผ ์ค ์ด ํ์์๊ฒ ์ ์์ฆ์ด ์๋ ๊ฒ์ ๋ฌด์์
๋๊น? | Tamsulosin | {
"A": "Hydrochlorothiazide",
"B": "Midodrine",
"C": "Oxybutynin",
"D": "Tamsulosin"
} | step1 | D | [
"76 year old African American man presents",
"primary care provider",
"urinary frequency",
"wakes up",
"times",
"night to",
"only",
"to wake up",
"night",
"post-void dribbling",
"difficulty initiating",
"stream of urine",
"denies",
"difficulty maintaining",
"erection",
"past medical history",
"notable",
"non-alcoholic fatty liver disease",
"hypertension",
"hyperlipidemia",
"gout",
"takes aspirin",
"atorvastatin",
"enalapril",
"allopurinol",
"family history",
"notable",
"prostate cancer",
"father",
"lung cancer",
"mother",
"pack-year smoking history",
"drinks alcohol",
"digital rectal exam",
"prostate",
"enlarged",
"smooth",
"non-tender",
"following medications",
"indicated",
"patient"
] | 00000000000000000016 |
68์ธ ๋จ์ฑ์ด ์ง๋ 4๊ฐ์ ๋์ ๋ฐ๋ณต์ ์ธ ๋ฉ์ค๊บผ์๊ณผ ๋ณต๋ถ ๋ถํธ๊ฐ์ ๋๊ปด ์์ฌ๋ฅผ ์ฐพ์๋ค. ๋ถํธ๊ฐ์ ์๋ณต๋ถ์ ์์นํ๋ฉฐ, ํนํ ๊ณผ์์ ํ ํ ์์ฌ ํ์ ์ข
์ข
๋ฐ์ํ๋ค. ๊ทธ๋ ์ํ๋ฅผ ๋๊ธฐ ์ํด ์ ๋
์์ฌ ํ ์ฐ์ฑ
์ ํ๋ ค๊ณ ํ์ง๋ง, ํธ์๋ ์
ํ๋๊ธฐ๋ง ํ๋ค. ์ง๋ 3์ฃผ ๋์ ์ํํธ ๊ณ๋จ์ ์ค๋ฅผ ๋๋ ์ฆ์์ด ๋ํ๋ฌ๋ค. ๊ทธ๋ ์ 2ํ ๋น๋จ๋ณ, ๊ณ ํ์, ๊ทธ๋ฆฌ๊ณ 2๋จ๊ณ ๋ง์ด ๋๋งฅ ์งํ์ ์๊ณ ์๋ค. ์ง๋ 45๋
๋์ ๋งค์ผ ํ ๊ฐ์ ๋ด๋ฐฐ๋ฅผ ํผ์ ๋ค. ๊ทธ๋ ๋งค์ผ ๋งฅ์ฃผ ํ๋ ์์ ๋ง์๊ณ , ์ฃผ๋ง์๋ ๊ฐ๋ ๋ ๋ง์ด ๋ง์ ๋ค. ํ์ฌ ๋ณต์ฉ ์ค์ธ ์ฝ๋ฌผ์ ๋ฉํธํฌ๋ฅด๋ฏผ, ์๋ ๋ผํ๋ฆด, ์์คํผ๋ฆฐ์ด๋ค. ๊ทธ์ ํค๋ 168cm (5 ft 6 in)์ด๊ณ , ๋ชธ๋ฌด๊ฒ๋ 126kg (278 lb)์ด๋ฉฐ; BMI๋ 45 kg/m2์ด๋ค. ๊ทธ์ ์ฒด์จ์ 36.4ยฐC (97.5ยฐF), ๋งฅ๋ฐ์ ๋ถ๋น 78ํ, ํ์์ 148/86 mm Hg์ด๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ๋ณต๋ถ๋ ๋ถ๋๋ฝ๊ณ ์ํต์ด ์์ผ๋ฉฐ ์ฅ๊ธฐ ๋น๋๋ ์๋ค. ๋ฐ ๋งฅ๋ฐ์ ์์ชฝ ๋ชจ๋์์ ์ด์ง๋์ง ์๋๋ค. ECG๋ ์ด์ ์๊ฒฌ์ ๋ณด์ด์ง ์๋๋ค. ๋ค์ ์ค ์ง๋จ์ ์ํ ๊ฐ์ฅ ์ ์ ํ ๋จ๊ณ๋ ๋ฌด์์ธ๊ฐ? | Cardiac stress test | {
"A": "์๋์์ญ์ด์ง์ฅ ๋ด์๊ฒฝ ๊ฒ์ฌ (Esophagogastroduodenoscopy)",
"B": "์์ ํธํก ๊ฒ์ฌ (Hydrogen breath test)",
"C": "์ฌ์ฅ ๋ถํ ๊ฒ์ฌ (Cardiac stress test)",
"D": "์ฐ์ ๋ณต๋ถ ์ด์ํ ๊ฒ์ฌ (Abdominal ultrasonography of the right upper quadrant)"
} | step2&3 | C | [
"68 year old man",
"physician",
"of recurrent episodes",
"nausea",
"abdominal discomfort",
"past",
"months",
"discomfort",
"upper abdomen",
"sometimes occurs",
"eating",
"big meal",
"to go",
"walk",
"dinner to help",
"digestion",
"complaints",
"only increased",
"past",
"weeks",
"symptoms",
"climbing",
"stairs",
"apartment",
"type 2 diabetes mellitus",
"hypertension",
"stage 2 peripheral arterial disease",
"smoked one pack",
"cigarettes daily",
"past",
"years",
"drinks one",
"two beers daily",
"occasionally",
"weekends",
"current medications include metformin",
"enalapril",
"aspirin",
"5 ft 6",
"tall",
"kg",
"BMI",
"kg/m2",
"temperature",
"36 4C",
"97",
"pulse",
"min",
"blood pressure",
"mm Hg",
"physical examination",
"abdomen",
"soft",
"nontender",
"organomegaly",
"Foot pulses",
"absent",
"ECG shows",
"abnormalities",
"following",
"most appropriate next step",
"diagnosis"
] | 00000000000000000017 |
27์ธ ์ฌ์ฑ์ด ์ ๊ธฐ ๊ฒ์ง์ ์ํด ์ผ๋ฐ ์์ ํด๋ฆฌ๋์ ๋ด์ํ์ต๋๋ค. ๊ทธ๋
๋ ์ผํ๋ฌผ ์์ก์ฒด ๋์ฐ๋ณ์ด๋ก ํน์ง์ง์ด์ง๋ ์ ์ ์งํ์ ๊ฐ์ง๊ณ ์์ต๋๋ค. ๊ทธ๋
๋ ๋ง์ฑ ๊ธฐ๊ด์ง์ผ ๋ณ๋ ฅ์ด ์์ต๋๋ค. ๊ทธ๋
์๊ฒ๋ ์ ์ฌํ ๊ฐ์ผ ๋ณ๋ ฅ๊ณผ ๋ถ์ ๋ณ๋ ฅ์ ๊ฐ์ง ํ์ ๊ฐ ์์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์ ๋ง์ฑ ์งํ์ ์ด์ฐจ์ ์ผ๋ก ๋ฐ์ํ๋ ์ ์ฌ์ ์ธ ๋นํ๋ฏผ ๊ฒฐํ ํฉ๋ณ์ฆ๊ณผ ๊ด๋ จํ์ฌ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ๊ฒ์ ๋ฌด์์
๋๊น? | It may manifest itself as a prolonged PT | {
"A": "It may result in corneal vascularization",
"B": "It may result in the triad of confusion, ophthalmoplegia, and ataxia",
"C": "It may be exacerbated by excessive ingestion of raw eggs",
"D": "It may manifest itself as a prolonged PT"
} | step1 | D | [
"27 year old female presents",
"general medical clinic",
"routine checkup",
"genetic disease marked",
"mutation",
"chloride transporter",
"history of chronic bronchitis",
"brother",
"similar history",
"infections",
"infertility",
"following",
"most likely true",
"potential vitamin deficiency complication secondary to",
"patient's chronic illness"
] | 00000000000000000018 |
์ด์ ์ ๊ฑด๊ฐํ๋ 36์ธ ๋จ์ฑ์ด 2์ฃผ ๋์ ํผ๋ถ์ ํฉ์ ๋ณ์๊ณผ ์ง์ ์ ์๋ณ์ผ๋ก ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ๊ทธ๋ ์ ์ ์ ํ ๋ง์์ง ์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ํฉ๋ฌ์ด ๋ํ๋ฌ์ต๋๋ค. ๋ณต๋ถ ๋ฐ ์ ๊ฒฝํ์ ๊ฒ์ฌ์์๋ ์ด์ ์๊ฒฌ์ด ๋ํ๋์ง ์์์ต๋๋ค. ํ์ฒญ ๊ฒ์ฌ ๊ฒฐ๊ณผ alanine aminotransferase (ALT)์ aspartate aminotransferase (AST) ์์น๊ฐ ์ฆ๊ฐํ ๊ฒ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ๊ฐ ์๊ฒ์ ์ค์ํ๊ณ periodic acid-Schiff-staining ํ์ ํ๋ฏธ๊ฒฝ ์ฌ์ง์ด ์ ์๋์์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์๊ฒ์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ถ๊ฐ ์๊ฒฌ์ ๋ฌด์์
๋๊น? | Bullous changes of the lung bases on chest CT | {
"A": "ํ๋ถ CT์์ ํ ๊ธฐ์ ๋ถ์ Bullous changes",
"B": "ERCP์์ ๊ฐ ๋ด์ธ ๋ด๊ด์ Beading",
"C": "์ฌํ๊ด MRI์์ ์ฌ๊ทผ ์ฒ ๋ถ ์นจ์ฐฉ",
"D": "์ธ๊ทน๋ฑ ๊ฒ์ฌ์์ ๊ฐ๋ง์ ์ง์ ๊ณ ๋ฆฌ"
} | step1 | A | [
"healthy 36 year old man",
"physician",
"yellow discoloration",
"skin",
"dark-colored urine",
"2 weeks",
"not drink",
"alcohol",
"Physical examination shows jaundice",
"Abdominal",
"neurologic examinations show",
"abnormalities",
"Serum studies show increased levels",
"alanine aminotransferase",
"ALT",
"aspartate aminotransferase",
"AST",
"liver biopsy",
"performed",
"photomicrograph",
"periodic acid-Schiff-staining",
"shown",
"following",
"most likely additional finding",
"patient"
] | 00000000000000000019 |
69์ธ ๋จ์ฑ์ด ์ํต์ผ๋ก ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ๊ทธ๋ ์ธ๊ฒฉ ์ฅ์ ๋ฐ ์ ์ด์ฑ ์ ๋ฆฝ์ ์ ๋ณ๋ ฅ์ด ์์ผ๋ฉฐ ์ธ๊ณผ์ ์ ์ ๋์์ด ์๋์์ต๋๋ค. ๊ทธ๋ ํํ ์๋ฒ์ ์์ํ์ง๋ง ๋ฉ์ถ์ง ์๋ ๋ฉ์ค๊บผ์์ผ๋ก ์ธํด ์ค๋จํ์ต๋๋ค. ๊ทธ๋ ๋ฐฐ๋ณ ๋๋ ๋ฐฉ๊ด ์ค๊ธ์ ๋ถ์ธํฉ๋๋ค. ๊ทธ๋ ์ด์ ์ ์ด์ ๊ฐ์ ํต์ฆ์ ๊ฒช์ ์ ์ด ์์ผ๋ฉฐ ๋ชจ๋ฅดํ์ ์๊ตฌํ๊ณ ์์ต๋๋ค. ๊ฐํธ์ฌ๋ IV ๋ชจ๋ฅดํ์ ํฌ์ฌํ๊ณ ๊ทธ๋ ๋ ํธ์ํจ์ ๋๋๋๋ค. ํ๋ ฅ ์งํ๋ ์์ ์ ์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ํ๋ถ ์ฒ์ถ๋ฅผ ๋ฐ๋ผ ์ด์ง์ ์ํต์ด ์๊ณ ์์ธก ํ์ง์ ์ ์ฝ์ด ์์ผ๋ฉฐ ์ผ์ชฝ์ด ์ค๋ฅธ์ชฝ๋ณด๋ค ๋ ์ฌํฉ๋๋ค. ์ ๊ฒฝํ์ ๊ฒ์ฌ์์๋ ์์ธก ๋ฌด๋ฆ ๋ฐ ๋ฐ๋ชฉ ๋ฐ์ฌ ์ ํ๊ฐ ์ฃผ๋ชฉ๋ฉ๋๋ค. ์ง์ฅ ๊ฒ์ฌ๋ฅผ ์ค์ํ ๊ฒฐ๊ณผ ์์ฅ ๋ง๋น๊ฐ ๋ํ๋ฌ์ต๋๋ค. ์ด ํ์์ ๋ํด ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ์๋ ์ง๋จ๊ณผ ์ ์ ํ ๋ค์ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | The most likely diagnosis is cauda equina syndrome and steroids should be started prior to MRI | {
"A": "๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ์๋ ์ง๋จ์ cauda equina syndrome์ด๋ฉฐ MRI ์ ์ ์คํ
๋ก์ด๋๋ฅผ ์์ํด์ผ ํฉ๋๋ค.",
"B": "๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ์๋ ์ง๋จ์ cauda equina syndrome์ด๋ฉฐ MRI ํ์ ์คํ
๋ก์ด๋๋ฅผ ์์ํด์ผ ํฉ๋๋ค.",
"C": "๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ์๋ ์ง๋จ์ cauda equina syndrome์ด๋ฉฐ ํ์๋ฅผ ๋ฐฉ์ฌ์ ์น๋ฃ๋ก ๊ธํ ์ฎ๊ฒจ์ผ ํฉ๋๋ค.",
"D": "๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ์๋ ์ง๋จ์ conus medullaris syndrome์ด๋ฉฐ MRI ์ ์ ์คํ
๋ก์ด๋๋ฅผ ์์ํด์ผ ํฉ๋๋ค."
} | step2&3 | A | [
"69 year old male presents",
"emergency room",
"back pain",
"history of personality disorder",
"metastatic prostate cancer",
"not",
"candidate",
"surgical resection",
"began chemotherapy",
"discontinued due to",
"nausea",
"denies",
"bowel",
"bladder incontinence",
"never",
"pain",
"before",
"demanding morphine",
"nurse administers IV morphine",
"feels more",
"Vital signs",
"stable",
"physical examination",
"note tenderness",
"palpation",
"lower spine",
"weakness in",
"bilateral lower extremities",
"left greater than right",
"Neurological examination",
"notable",
"hyporeflexia",
"knee",
"ankle jerks",
"conduct",
"rectal examination",
"reveals saddle anesthesia",
"patient",
"most likely diagnosis",
"appropriate next step",
"management"
] | 00000000000000000020 |
ํ ์ฐ๊ตฌ์๊ฐ ์คํ ๋๋ฌผ์ ์์ํ๋ถ ์ธ์ธกํต์ ๊ธฐ๋ฅ์ ์ฐ๊ตฌํ๊ณ ์์ต๋๋ค. ๋ฐ์ด๋ฌ์ค ๋ฒกํฐ๋ฅผ ์ฌ์ฉํ์ฌ ์ผ์ ์ด์จ์ ์ ๋ํ๋ ์ฑ๋๋ก๋์ ์ ์ํธํํ๋ ์ ์ ์๊ฐ ์ด ํต์ ์ฃผ์
๋ฉ๋๋ค. ์ฑ๋์ ๊ด ์๊ทน์ ํ๋ ์ ์ ์์ฑ์ ์์ ํ ์ต์ ๋ฅผ ์ ๋ฐํฉ๋๋ค. ์ง์์ ์ธ ๊ด ์๊ทน์ ์ด๋ฌํ ๋๋ฌผ์๊ฒ ๋ค์ ์ด์ ์ค ๋ฌด์์ ์ด๋ํ ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ๋์ต๋๊น? | Anorexia | {
"A": "์ ์ฒด์จ์ฆ",
"B": "๊ณ ์ฒด์จ์ฆ",
"C": "๋ค์๋ค์ฆ",
"D": "์์ ๋ถ์ง"
} | step1 | D | [
"investigator",
"studying",
"function",
"lateral nucleus",
"hypothalamus",
"experimental animal",
"Using",
"viral vector",
"genes encoding chloride conducting channelrhodopsins",
"injected",
"nucleus",
"channels causes complete inhibition",
"Persistent",
"most likely to result",
"following abnormalities",
"animals"
] | 00000000000000000021 |
52์ธ ์ฌ์ฑ์ด 6๊ฐ์ ๋์์ ์ ์ ํผ๋ก, ๋ฏธ์ด, ๊ทธ๋ฆฌ๊ณ 10kg (22lb) ์ฒด์ค ๊ฐ์๋ฅผ ์ด์ ๋ก ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ์ ๋ฐ์ ์ธ ์ฐฝ๋ฐฑ๊ณผ ๋น์ฅ๋น๋๊ฐ ๋ํ๋ฌ์ต๋๋ค. ๊ทธ๋
์ ํค๋ชจ๊ธ๋ก๋น ๋๋๋ 7.5 g/dL์ด๊ณ ๋ฐฑํ๊ตฌ ์๋ 41,800/mm3์
๋๋ค. Leukocyte alkaline phosphatase ํ์ฑ๋๋ ๋ฎ์ต๋๋ค. ๋ง์ด ํ์ก ๋๋ง ๊ฒ์ฌ์์ ๊ณจ์์ธํฌ์ ํ๊ณจ์์ธํฌ๋ฅผ ๋๋ฐํ ํธ์ผ๊ธฐ๊ตฌ ์ฆ๊ฐ์ฆ์ด ๊ด์ฐฐ๋ฉ๋๋ค. ๊ณจ์ ์๊ฒ ๊ฒฐ๊ณผ ๋ฏธ์ฑ์ ๊ณผ๋ฆฝ๊ตฌ ์ธํฌ์ ์ฆ์์ ๋๋ฐํ ์ธํฌ ๊ณผํ์ฑ์ด ๋ํ๋ฌ์ต๋๋ค. ๋ค์ ์ค ์ด๋ค ๊ธฐ์ ์ด ์ด ํ์์ ์ํ์ ๊ฐ์ฅ ํฐ ์์ธ์ผ ๊ฐ๋ฅ์ฑ์ด ๋์ต๋๊น? | Unregulated expression of the ABL1 gene | {
"A": "Cytokine-independent activation of the JAK-STAT pathway",
"B": "Loss of function of the APC gene",
"C": "Altered expression of the retinoic acid receptor gene",
"D": "Unregulated expression of the ABL1 gene"
} | step1 | D | [
"year old woman",
"physician",
"month history",
"generalized fatigue",
"low-grade fever",
"a 10 kg",
"weight loss",
"Physical examination shows generalized pallor",
"splenomegaly",
"hemoglobin concentration",
"7.5 g/dL",
"leukocyte count",
"800 mm3",
"Leukocyte alkaline phosphatase activity",
"low",
"Peripheral blood smear shows basophilia",
"myelocytes",
"metamyelocytes",
"Bone marrow biopsy shows cellular hyperplasia",
"proliferation",
"immature granulocytic",
"following mechanisms",
"most likely responsible",
"patient's condition"
] | 00000000000000000022 |
42์ธ ์ฌ์ฑ์ด 3์ผ ์ ์ ์ํํ ๋ด๋ญ์ ์ ์ ํ ๋ด๊ด์ผ์ผ๋ก ์ธํด ๋ณ์์์ ํ๋ณต ์ค์
๋๋ค. ๊ทธ๋
๋ IV piperacillin-tazobactam์ผ๋ก ์น๋ฃ๋ฅผ ๋ฐ๊ณ ์์ต๋๋ค. ๊ทธ๋
๋ ๊ฐํธ์ฌ๋ฅผ ๋ถ๋ฌ ์์ ์ ์ฌ์ฅ์ด ๋๋ฌด ๋นจ๋ฆฌ ๋ฐ๊ณ ์๋ค๊ณ ๋งํฉ๋๋ค. ๋ํ ๋ฐ๋ฅ์ ์์ธ ์ฐ๋ ๊ธฐ๊ฐ ํ๋ฆฌ๋ฅผ ๊ผฌ์ด๊ฒ ํ๋ค๋ฉฐ ๋๊ตฐ๊ฐ ์์ ์น์๋ฌ๋ผ๊ณ ์๊ตฌํฉ๋๋ค. ๊ทธ๋
์ ๋งฅ๋ฐ์ 112/๋ถ, ํธํก์๋ 20/๋ถ, ์ฒด์จ์ 38.0ยฐC (100.4ยฐF), ํ์์ 150/90 mm Hg์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ํ์๋ ๋์ ํ๋ฆฌ๊ณ ๊ดด๋ก์ํ๋ฉฐ ๊ฐ๋งํ ์์ง ๋ชปํ๋ ๋ชจ์ต์
๋๋ค. ๊ทธ๋
๋ ์ฌ๋์ ๋ํด์๋ ์ง๋จ๋ ฅ์ด ์์ง๋ง, ์ฅ์๋ ์๊ฐ์ ๋ํด์๋ ๊ทธ๋ ์ง ๋ชปํฉ๋๋ค. ๋ณต๋ถ ์ด์ง ์ ์ํต, ๋ฐ๋ํต ๋๋ ๊ฐ์ง์ ๋ณด์ด์ง ์์ต๋๋ค. ์ด ํ์์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ์๋ ์ง๋จ์ ๋ฌด์์
๋๊น? | Delirium tremens | {
"A": "Acute cholangitis",
"B": "Alcoholic hallucinosis",
"C": "Delirium tremens",
"D": "Hepatic encephalopathy"
} | step1 | C | [
"year old woman",
"hospital recovering",
"cholecystectomy performed 3 days",
"complicated",
"cholangitis",
"treated with IV piperacillin-tazobactam",
"calls",
"nurse",
"room",
"heart",
"racing",
"demands",
"clean",
"pile",
"garbage",
"floor",
"flies",
"pulse",
"min",
"respiratory rate",
"20 min",
"temperature",
"100 4F",
"blood pressure",
"90 mm Hg",
"physical examination",
"patient appears sweaty",
"distressed",
"unable to",
"oriented to person",
"not place",
"time",
"Palpation of",
"abdomen shows",
"tenderness",
"guarding",
"following",
"most likely diagnosis",
"patient"
] | 00000000000000000023 |
48์ธ ์ฌ์ฑ ํ์๊ฐ 3์ฃผ ์ ๋ถํฐ ์, ํ๋, ์ผ๊ตด์ ๊ด๊ณผ๋ฏผ์ฑ ์ํฌ์ฑ ๋ฐ์ง์ด ์๊ฒจ ์๊ธ์ค์ ๋ด์ํ์๋ค. ๋ณ๋ณ์ ๊ฐ๋ ต์ง ์๋ค. ํ์๋ ์ต๊ทผ ์๋ณ ์๊น์ด ์ง์ ๊ฐ์์ผ๋ก ๋ณํ ๊ฒ์ ์์์ฐจ๋ ธ๋ค. 20๋
์ , ํ์๋ ๋ง๋ง ๊ฒฝํ ์๋ฒ์ ํตํด ๋ง๋ง์ Coats ๋ณ์ ์ฑ๊ณต์ ์ผ๋ก ์น๋ฃ๋ฐ์๋ค. ํ์ฌ ํ์๋ ํ๊ฒฝ ์ ์ฆ์์ผ๋ก ํธ๋ฅด๋ชฌ ๋์ฒด ์๋ฒ์ ๋ฐ๊ณ ์๋ค. ํ์์ ๊ณ ๋ชจ์ ์ฌ๋์์ ์ ์ฌํ ํผ๋ถ ๋ณ๋ณ์ ๋ณ๋ ฅ์ ๊ฐ์ง๊ณ ์๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ํ๋, ์์ชฝ ์์ ๋ฐฐ๋ฉด, ์ด๋ง์ ๋ค์์ ์ก์ฒด๋ก ์ฑ์์ง ๋ฌผ์ง๊ณผ ์ง๋ฌผ์ด ๋๋ ๋ฏธ๋์ด ๊ด์ฐฐ๋์๋ค. ๋ฌผ์ง์ ๊ฐ์ฅ์๋ฆฌ์๋ ๊ณผ๋ค ์์ ์นจ์ฐฉ ํํฐ์ ๋ถ๋ถ์ ์ธ ํ๋ชจ ๋ฐ์ ์ด ๊ด์ฐฐ๋๋ค. ์คํ์ค ๊ฒ์ฌ ๊ฒฐ๊ณผ ํ์ฒญ ํ๋ฆฌํด ๋๋๋ ์ ์์ด์๋ค. ์ด ํ์์ ๊ดํด๋ฅผ ์ ๋ํ๊ธฐ ์ํ ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ์ ์น๋ฃ๋ฒ์ ๋ฌด์์ธ๊ฐ? | Begin phlebotomy therapy | {
"A": "๊ฐ ์ด์ ์๋",
"B": "๊ฒฝ๊ตฌ ํ๋ฆฌ๋๋ง์ด๋ ์๋ฒ ์์",
"C": "์ฌํ ์๋ฒ ์์",
"D": "๊ฒฝ๊ตฌ ํ์ด๋๋ก์ํด๋ก๋กํธ ์๋ฒ ์์"
} | step2&3 | C | [
"48 year old woman",
"emergency department",
"of",
"photosensitive blistering",
"hands",
"forearms",
"face",
"weeks",
"lesions",
"not itchy",
"urine",
"dark brown",
"color recently",
"Twenty years",
"treated",
"Coats",
"retina",
"retinal sclerotherapy",
"currently",
"hormonal replacement",
"perimenopausal symptoms",
"aunt",
"sister",
"history of",
"similar skin lesions",
"Examination shows multiple fluid filled blisters",
"erosions",
"forearms",
"dorsal side",
"hands",
"forehead",
"hyperpigmented scarring",
"patches",
"bald skin",
"sides",
"blisters",
"Laboratory studies show",
"normal serum ferritin concentration",
"following",
"most appropriate next step",
"management to induce remission in",
"patient"
] | 00000000000000000024 |
53์ธ ๋จ์ฑ์ด 3์๊ฐ ๋์ ์ฌํ ์ค๋ฅธ์ชฝ ์๊ตฌ๋ฆฌ ํต์ฆ์ผ๋ก ์๊ธ์ค์ ๋ด์ํ๋ค. ํต์ฆ์ ์ฐํต์ฑ์ด๊ณ , ์ค๋ฅธ์ชฝ ์ํ๋ถ๋ก ๋ฐฉ์ฌ๋๋ฉฐ, ๊ฐ๋๋ 10์ ๋ง์ ์ 8์ ์ผ๋ก ๋ฌ์ฌํ๋ค. ๊ทธ๋ ํ ๋ฒ ๊ตฌํ ํ๋ค. ๊ณผ๊ฑฐ์ ์ ์ฌํ ์ํผ์๋๋ ์์๋ค. ์๋
์ ๊ทธ๋ ์ค๋ฅธ์ชฝ ๋ฐ๊ฐ๋ฝ์ ๋ถ๊ธฐ์ ํต์ฆ์ผ๋ก ๋ํ๋ก์ผ์ผ๋ก ์น๋ฃ๋ฐ์๋ค. ๊ณ ํ์ ๋ณ๋ ฅ์ด ์๋ค. ์ฃผ๋ง์๋ ๋งฅ์ฃผ ํ๋ ์์ ๋ง์ ๋ค. ํ์ฌ ๋ณต์ฉํ๋ ์ฝ๋ฌผ์ ์๋ก๋ํ์ด๋ค. ๊ทธ๋ ๋ถํธํด ๋ณด์ธ๋ค. ์ฒด์จ์ 37.1ยฐC (99.3ยฐF), ๋งฅ๋ฐ์ 101/min, ํ์์ 130/90 mm Hg์ด๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋ณต๋ถ๋ ๋ถ๋๋ฝ๊ณ ์ํต์ด ์์ผ๋ฉฐ, ์ค๋ฅธ์ชฝ ๋๊ณจ์ฒ์ถ๊ฐ ์ํต์ด ๋ํ๋ฌ๋ค. ๋ณต๋ถ์ ๊ธฐ๋ฆฝ ๋จ์ X์ ์ดฌ์ ๊ฒฐ๊ณผ ์ด์์ ์์๋ค. ๋ณต๋ถ ๋ฐ ๊ณจ๋ฐ CT ์ค์บ ๊ฒฐ๊ณผ ๊ทผ์ ์๊ด์ 7mm ๊ฒฐ์์ด ์๊ณ , ์ค๋ฅธ์ชฝ์์ 1๋จ๊ณ ์์ ์ฆ์ด ๋ํ๋ฌ๋ค. ๋ค์ ์ค ์ ๊ฒ์ฌ์์ ๊ฐ์ฅ ํํ๊ฒ ๋ํ๋ ์ ์๋ ๊ฒ์ ๋ฌด์์ผ๊น? | Urinary pH: 4.7 | {
"A": "์ pH: 7.3",
"B": "์ pH: 4.7",
"C": "์์ฑ ์์ง์ฐ์ผ ๊ฒ์ฌ",
"D": "๋๋ ์์ฑ ์ ๋จ๋ฐฑ"
} | step2&3 | B | [
"year old man",
"emergency department",
"of severe right-sided flank pain",
"hours",
"pain",
"colicky",
"radiates",
"right groin",
"8/10",
"intensity",
"vomited",
"history of similar episodes",
"past",
"year",
"treated with naproxen",
"swelling",
"pain",
"right toe",
"history of hypertension",
"drinks one",
"two beers",
"weekends",
"Current medications include amlodipine",
"appears",
"temperature",
"99",
"pulse",
"min",
"blood pressure",
"90 mm Hg",
"Examination shows",
"soft",
"nontender abdomen",
"right costovertebral angle tenderness",
"upright x-ray of",
"abdomen shows",
"abnormalities",
"CT scan",
"abdomen",
"pelvis shows",
"7-mm stone",
"proximal ureter",
"grade I hydronephrosis",
"right",
"following",
"most likely to",
"seen",
"urinalysis"
] | 00000000000000000025 |
5์ธ ์ฌ์๊ฐ ๊ณผ๋ํ ํธ ์ฑ์ฅ์ผ๋ก ์ธํด ์ด๋จธ๋์ ์ํด ํด๋ฆฌ๋์ผ๋ก ์ด์ก๋์์ต๋๋ค. ์ด๋จธ๋๋ ์ง๋ 2๊ฐ์ ๋์ ๊ฒจ๋๋์ด์ ์๋ถ ๋ถ์์ ํธ์ด ๋๋ ๊ฒ์ ๋ฐ๊ฒฌํ๋ค๊ณ ๋ณด๊ณ ํฉ๋๋ค. ๊ทธ๋
๋ ์ฑ์กฐ์์ฆ์ ๊ฐ์กฑ๋ ฅ์ ๋ถ์ธํ๊ณ ๋ธ์ด ๋น๊ต์ ๊ฑด๊ฐํ์ผ๋ฉฐ ํฉ๋ณ์ฆ ์๋ ์ถ์ฐ๋ ฅ์ ๊ฐ์ง๊ณ ์๋ค๊ณ ๋ณด๊ณ ํฉ๋๋ค. ๊ทธ๋
๋ ์ต๊ทผ์ ์ง๋ณ, ์ฒด์ค ๋ณํ, ๋ฐ์ด, ์ง ์ถํ, ํต์ฆ ๋๋ ์ฝ๋ฌผ ์ฌ์ฉ์ ๋ถ์ธํฉ๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ Tanner stage 4 ๋ฐ๋ฌ์ด ๋ํ๋ฌ์ต๋๋ค. ๊ณจ๋ฐ ์ด์ํ์์ ๋์ ์ข
๊ดด๊ฐ ๋ณด์
๋๋ค. ์คํ์ค ์ฐ๊ตฌ์์ ์์คํธ๋ก๊ฒ ์์น๊ฐ ์์นํ ๊ฒ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Granulosa cell tumor | {
"A": "Granulosa cell tumor",
"B": "Idiopathic precocious puberty",
"C": "McCune-Albright syndrome",
"D": "Sertoli-Leydig tumor"
} | step2&3 | A | [
"5 year old girl",
"brought",
"clinic",
"mother",
"excessive hair growth",
"mother reports",
"past",
"months",
"hair",
"axillary",
"pubic areas",
"denies",
"family history",
"precocious puberty",
"reports",
"daughter",
"relatively healthy",
"uncomplicated birth history",
"denies",
"recent illnesses",
"weight change",
"fever",
"vaginal bleeding",
"pain",
"medication use",
"Physical examination demonstrates Tanner stage 4 development",
"pelvic ultrasound shows",
"ovarian mass",
"Laboratory studies demonstrates",
"elevated level",
"estrogen",
"most likely diagnosis"
] | 00000000000000000026 |
16์ธ ์๋
์ด ์ด๋จธ๋์ ์ํด ์์ฌ์๊ฒ ์ง์ฐฐ์ ๋ฐ์ผ๋ฌ ์๋๋ฐ, ์ด๋ ๊ทธ์ ํ๋์ ๋ํ ์ด๋จธ๋์ ๊ฑฑ์ ๋๋ฌธ์ด๋ค. ์ด์ , ๊ทธ๋ ์์
์ ๋ฐ๋ณต์ ์ผ๋ก ๋น ์ง ์ด์ ๋ก ํ๊ต์์ ํดํ๋นํ๋ค. ์ง๋ 2๊ฐ์ ๋์, ๊ทธ๋ ๋๋ฃ ๋ฐ ๊ต์ฌ์ ๋ํ ๊ดด๋กญํ๊ณผ ๊ณต๊ฒฉ์ ์ธ ํ๋์ผ๋ก 3๋ฒ ์ ํ ์ฒ๋ถ์ ๋ฐ์๋ค. ํ ๋ฒ์ ๊ทธ์ ์ด์์ด ๊ทธ๊ฐ ๋ท๋ง๋น์์ ๋ด๋ฐฐ๋ฅผ ํผ์ฐ๋ ๊ฒ์ ๋ฐ๊ฒฌํ๋ค. ๊ณผ๊ฑฐ์๋ ๊ทธ๋ ๊พธ์คํ Aํ์ ํ๊ท ์ ์ ์งํ์ผ๋ฉฐ, ์ง์ญ ๊ตํ์์ ์ด๋ฆฌ๋ ์ฒญ์๋
๊ทธ๋ฃน ํ์ฌ์ ์ ๊ธฐ์ ์ผ๋ก ์ฐธ์ํ์๋ค. ์ด๋จธ๋๋ 3๊ฐ์ ์ , ์๋ฒ์ง๊ฐ ์๋ด๊ฐ ์ธ๋ํ๊ณ ์์์ ์๊ฒ ๋ ํ ์ง์ ๋๊ฐ ์์ ์ฆ์์ ์ด๋ฌํ ํ๋ ๋ณํ๋ฅผ ์ฒ์ ์ธ์งํ๋ค. ๋ค์ ๋ฐฉ์ด ๊ธฐ์ ์ค ์ด ํ์์ ํ๋ ๋ณํ๋ฅผ ๊ฐ์ฅ ์ ์ค๋ช
ํ๋ ๊ฒ์ ๋ฌด์์ธ๊ฐ? | Acting out | {
"A": "Acting out (ํ๋ํ)",
"B": "Projection (ํฌ์ฌ)",
"C": "Passive aggression (์๋ ๊ณต๊ฒฉ์ฑ)",
"D": "Regression (ํดํ)"
} | step1 | A | [
"year old boy",
"brought",
"physician",
"mother",
"worried",
"behavior",
"expelled from school",
"repeatedly skipping classes",
"past",
"months",
"suspended 3 times",
"bullying",
"aggressive behavior",
"peers",
"teachers",
"neighbor found",
"smoking cigarettes",
"backyard",
"past",
"maintained",
"grade average",
"a regular",
"youth group events",
"local church",
"mother first",
"change in behavior",
"months",
"time",
"father moved out",
"discovering",
"wife",
"following defense mechanisms best",
"change in",
"patient's behavior"
] | 00000000000000000027 |
63์ธ ์ฌ์ฑ ํ์๊ฐ 2๊ฐ์ ์ ๋ถํฐ ์๋ ฅ ๋ณํ๋ฅผ ๊ฒช์ด ์ฃผ์น์์๊ฒ ์ง๋ฃ๋ฅผ ๋ฐ์ผ๋ฌ ์์ผ๋ฉฐ, ํนํ ๋ณต์๊ฐ ์ ์ง์ ์ผ๋ก ์์๋์๋ค๊ณ ์ง์ ํ์ต๋๋ค. ๋ณต์๋ ํญ์ ๋ํ๋๋ฉฐ ํ๋ฃจ ์ข
์ผ ํธ์ ๋๊ฑฐ๋ ์
ํ๋์ง ์์ต๋๋ค. ๋ํ ์ค๋ฅธ์ชฝ ๋์ ๋จ๊ธฐ ํ๋ค๊ณ ๊ฑฐ์ธ์ ๋ณด๋ฉด ์ค๋ฅธ์ชฝ ๋๊บผํ์ด '์ฒ์ ธ' ๋ณด์ธ๋ค๊ณ ๋๊ผ์ต๋๋ค. ์ ๋ฉด ์ฃผ์ ์ ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ์ฌ์ง์ ๋์ ์์ต๋๋ค. ์ค๋ฅธ์ชฝ ๋๊ณต์ 6mm์ด๋ฉฐ ๋น์ ๋ํ ๋ฐ์์ด ์ข์ง ์์ต๋๋ค. ๋๋จธ์ง ์ ๊ฒฝํ์ ๊ฒ์ฌ๋ ํน์ด ์ฌํญ์ด ์์ต๋๋ค. ์คํ์ค ๊ฒ์ฌ ๊ฒฐ๊ณผ Hb A1c๋ 5.0%์
๋๋ค. ๋ค์ ์ค ์ด ํ์์๊ฒ ๊ฐ์ฅ ์ ํฉํ ๊ฒ์ฌ๋ ๋ฌด์์
๋๊น? | MR angiography of the head | {
"A": "์ง์ ๊ฒ์๊ฒฝ ๊ฒ์ฌ",
"B": "์์",
"C": "๋จธ๋ฆฌ์ MR ํ๊ด ์กฐ์์ ",
"D": "์ธก๋ ๋๋งฅ ์๊ฒ"
} | step2&3 | C | [
"63 year old woman presents",
"primary-care doctor",
"2 month history",
"vision changes",
"gradual onset",
"double vision",
"double vision",
"present",
"time",
"not",
"better",
"worse",
"day",
"hard time keeping",
"right eye open",
"right eyelid looks",
"mirror",
"Physical exam findings",
"primary gaze",
"shown",
"right pupil",
"6 mm",
"poorly reactive to light",
"rest",
"neurologic exam",
"unremarkable",
"Laboratory studies show",
"Hb A1c",
"5.0",
"following",
"next best test",
"patient"
] | 00000000000000000028 |
ํ ์ฐ๊ตฌ์๊ฐ ๋ฐฐ์๋ ์งํต ์ธํฌ์์ ์๋ก ํ์ฑ๋ ํด๋ฆฌํฉํ์ด๋์ ๋ณํ์ ์ฐ๊ตฌํ๊ณ ์์ต๋๋ค. ํด๋ฆฌํฉํ์ด๋๊ฐ ๋ฆฌ๋ณด์์์ ๋ฐฉ์ถ๋ ํ, ํํ์ ์ผ๋ก ํ๊ทธ๋ ๋จ๋ฐฑ์ง์ด ํด๋ฆฌํฉํ์ด๋ ์ฌ์ฌ์ lysine ์๊ธฐ์ ๊ณต์ ๊ฒฐํฉํ์ฌ ๋ณํ๋ ํด๋ฆฌํฉํ์ด๋๋ฅผ ํ์ฑํฉ๋๋ค. ํต ๋ชจ์์ ๋ณตํฉ์ฒด๊ฐ ์ธํฌ์ง์ ์ฒจ๊ฐ๋๋ฉด ๋ณํ๋ ํด๋ฆฌํฉํ์ด๋๋ ์ฉํด๋์ด ๊ฐ๋ณ ์๋ฏธ๋
ธ์ฐ๊ณผ ํํ์ ์ผ๋ก ํ๊ทธ๋ ๋จ๋ฐฑ์ง์ ์์ฑํฉ๋๋ค. ๋ค์ ์ค ์ด๋ค ๋ฒ์ญ ํ ๋ณํ์ด ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ต๋๊น? | Ubiquitination | {
"A": "Glycosylation",
"B": "Phosphorylation",
"C": "Carboxylation",
"D": "Ubiquitination"
} | step1 | D | [
"investigator",
"studying",
"modification",
"newly formed polypeptides",
"plated eukaryotic cells",
"polypeptides",
"released",
"ribosome",
"a chemically tagged protein",
"lysine residues",
"polypeptide chain",
"forming",
"modified polypeptide",
"barrel-shaped complex",
"added",
"cytoplasm",
"modified polypeptide lyses",
"resulting in individual amino acids",
"chemically tagged proteins",
"following post-translational modifications",
"most likely occurred"
] | 00000000000000000029 |
38์ธ ๋จ์ฑ์ด ์ผ์ฃผ์ผ ๋์ ์ง์๋๋ ๋ณต์๋ก ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ๊ทธ๊ฐ ์ง์ฐฐ์ค์ ๋ค์ด์์ ๋, ์์ฌ๋ ํ์๊ฐ ๊ด๋ฒ์ํ ๋ณดํ์ ํ๋ ๊ฒ์ ์์์ฐจ๋ฆฝ๋๋ค. ๋จ์ฑ์ ์๋ด๋ ์์ฌ์๊ฒ ๊ทธ๊ฐ ์ง๋ 5๋
๋์ ์์ฝ์ฌ ์ค๋
์์์ผ๋ฉฐ ์ง๋ ๋ช ๋ฌ ๋์ ์์ฝ์ฌ ์๋น๊ฐ ์๋นํ ์ฆ๊ฐํ๋ค๊ณ ์๋ฆฝ๋๋ค. ๊ทธ๋
๋ ๋ํ ๊ทธ๊ฐ ์๊ฐ์ด ์ง๋จ์ ๋ฐ๋ผ ๊ฐ์กฑ ๊ตฌ์ฑ์์๊ฒ ๋ฌด๊ด์ฌํด์ก๊ณ ์์ฃผ ๋ถ์ํดํ๋ค๊ณ ๋ณด๊ณ ํฉ๋๋ค. ๊ทธ๋
๋ ๋ํ ๊ทธ์ ๊ธฐ์ต๋ ฅ์ด ์๋นํ ์์๋์์ผ๋ฉฐ ํน์ ์ธ๋ถ ์ฌํญ์ ๋ํด ์ง๋ฌธ์ ๋ฐ์ผ๋ฉด ์ข
์ข
๋ถ์ ํํ๊ฒ ๊ธฐ์ตํ์ง๋ง ์์ ์ ๋ฒ์ ์ด ์ง์ค์ด๋ผ๊ณ ์ฃผ์ฅํ๋ค๊ณ ๋งํฉ๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ๊ทธ์ ํ๋ ฅ ์งํ๋ ์์ ์ ์ด์ง๋ง ์์ฌ๊ฐ ๊ทธ์๊ฒ ํ์ฌ ์์น๋ฅผ ๋ฌผ์ผ๋ฉด ํผ๋์ค๋ฌ์ํ๋ ๊ฒ ๊ฐ์ต๋๋ค. ๊ทธ์ ์ ๊ฒฝํ์ ๊ฒ์ฌ์์๋ ์์ง์ด ๋ํ๋ฉ๋๋ค. ๋ค์ ์ต์
์ค ์ด ๋จ์ฑ์ ์ค์ถ ์ ๊ฒฝ๊ณ ๋ณํ์๋ฆฌํ์์ ๊ฐ์ฅ ์ด๊ธฐ์ ๋ฐ์ํ๋ ๋ณํ๋ฅผ ์ค๋ช
ํ๋ ๊ฒ์ ๋ฌด์์
๋๊น? | Decreased ฮฑ-ketoglutarate dehydrogenase activity in astrocytes | {
"A": "Astrocytes์์ ๊ฐ์๋ ฮฑ-ketoglutarate dehydrogenase ํ์ฑ",
"B": "์ฆ๊ฐ๋ extracellular concentration of glutamate",
"C": "์ฆ๊ฐ๋ astrocyte lactate",
"D": "ํ์ก-๋ ์ฅ๋ฒฝ์ ๋ถ๊ดด"
} | step2&3 | A | [
"year old man presents",
"physician",
"double vision",
"week",
"enters",
"exam room",
"physician notes",
"patient",
"broad-based gait",
"mans wife informs",
"doctor",
"alcoholic",
"years",
"consumption",
"alcohol",
"increased",
"past",
"months",
"reports",
"indifferent",
"family members",
"time",
"frequently agitated",
"memory",
"affected",
"detail",
"often recollects",
"version",
"true one",
"physical examination",
"vital signs",
"stable",
"doctor",
"to",
"confused",
"neurological examination",
"shows nystagmus",
"following options",
"earliest change",
"pathophysiology",
"central nervous system",
"man"
] | 00000000000000000030 |
69์ธ ๋จ์ฑ์ด ์๋ค๊ณผ ํจ๊ป ์ค๋ฅธ์ชฝ ํ๊ณผ ๋ค๋ฆฌ์ ์ ์ฝ์ ํธ์ํ๋ฉฐ ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ํ์๋ ๊ด์ฐฎ๋ค๊ณ ์ฃผ์ฅํ๋ฉฐ, ์๋ค์ด "๊ณตํฉ ์ํ๋ฅผ ์กฐ์ฑํ๋ค"๊ณ ๋น๋ํฉ๋๋ค. 4์๊ฐ ์ , ํ์๋ ์๋ด์ ์ฐจ๋ฅผ ๋ง์๋ ์ค ๊ฐ์๊ธฐ ์ฐป์์ ๋จ์ด๋จ๋ ธ์ต๋๋ค. ๊ทธ ์ดํ๋ก ์ค๋ฅธ์ชฝ ํ์ ์์ง์ด๋ ๋ฐ ์ด๋ ค์์ ๊ฒช๊ณ ์์ผ๋ฉฐ, ์ค๋ฅธ์ชฝ ๋ค๋ฆฌ๊ฐ ๊ตณ์ ๋๋ ๋๋ฌธ์ ๊ฑท์ง ๋ชปํฉ๋๋ค. ๊ทธ๋ ๊ณ ํ์๊ณผ ๊ณ ์งํ์ฆ์ ๋ณ๋ ฅ์ด ์์ผ๋ฉฐ, ํ์ฌ ๊ฐ๊ฐ lisinopril๊ณผ atorvastatin์ ๋ณต์ฉํ๊ณ ์์ต๋๋ค. ์์คํผ๋ฆฐ๊ณผ ๋
์ฝฉ์ ์๋ ๋ฅด๊ธฐ๊ฐ ์์ต๋๋ค. ์ ์ฐํ ๋จ์ธต ์ดฌ์(CT) ์ค์บ ๊ฒฐ๊ณผ ํํ์ฑ ๋์กธ์ค์ ์งํ๊ฐ ๋ํ๋ฌ์ต๋๋ค. ์ด ํ์์๊ฒ ํฅํ ์ด๋ฌํ ๋ฐ์์ ์๋ฐฉํ ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ๋์ ์ฝ๋ฌผ์ ๋ฌด์์
๋๊น? | Clopidogrel | {
"A": "Alteplase",
"B": "Urokinase",
"C": "Celecoxib",
"D": "Clopidogrel"
} | step1 | D | [
"69 year old man",
"brought",
"son",
"emergency department",
"weakness",
"right arm",
"leg",
"man",
"fine",
"blames",
"son",
"creating panic",
"Four hours",
"patient",
"tea",
"wife",
"dropped",
"difficulty moving",
"right arm",
"then",
"walk",
"right leg feels",
"history of hypertension",
"dyslipidemia",
"currently takes lisinopril",
"atorvastatin",
"allergic",
"aspirin",
"peanuts",
"computerized tomography",
"scan shows evidence",
"ischemic stroke",
"medication",
"most likely prevent",
"attacks",
"patient",
"future"
] | 00000000000000000031 |
70์ธ ๋จ์ฑ์ด ์ต๊ทผ ๋ฉฐ์น ๋์ ์๋ณ์ ํ์ก์ด ์์ฌ ๋์ค๊ณ ํ๋ณต๋ถ ํต์ฆ์ด ์๋ค๊ณ ์๋ฃ ํด๋ฆฌ๋์ ๋ด์ํ์ต๋๋ค. ๊ทธ๋ ๋ํ ๋น๋จ์ ์ ๋ฐ๋จ์ ๋ํด์๋ ์ฐ๋ คํ๊ณ ์์ต๋๋ค. ๊ทธ๋ ์ต๊ทผ ๋นํธ์งํจ ๋ฆผํ์ข
์ ๋ํ ํํ ์๋ฒ ์ฃผ๊ธฐ๋ฅผ ๋ง์ณค๋ค๊ณ ๋งํฉ๋๋ค. ํํ ์๋ฒ ์๋ฒ์์ ๊ทธ์ ์ฆ์์ ๊ฐ์ฅ ์ ๋ฐํ์ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ฝ๋ฌผ์ ๋ฌด์์
๋๊น? | Cyclophosphamide | {
"A": "Methotrexate",
"B": "Rituximab",
"C": "Cyclophosphamide",
"D": "Prednisone"
} | step1 | C | [
"70 year old man presents",
"medical clinic reporting blood",
"urine",
"lower abdominal pain",
"past",
"days",
"concerned",
"urinary frequency",
"urgency",
"states",
"recently completed",
"cycle",
"chemotherapy",
"non-Hodgkin lymphoma",
"medication",
"chemotherapy",
"likely caused",
"symptoms"
] | 00000000000000000032 |
27์ธ ๋จ์ฑ์ด ๊ฐ์ ๋ฌผ๋ฆฐ ํ ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ํ์๋ ์ ์ ์ทจํ ์ํ์์ผ๋ฉฐ, ๊ฐ๊ฐ ์์ฌํ๋ ๋์ ๊ฐ์ ๊ผฌ๋ฆฌ๋ฅผ ์ก์๋น๊ฒผ์ต๋๋ค. ๊ฐ๋ ๊ทธ์ ์น๊ตฌ ์์ ์ด๋ฉฐ ํ์ฌ ์น๊ตฌ ์ง์ ์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ํ์์ ์ค๋ฅธ์ชฝ ํ์ ๊ฐ์ ๋ฌผ๋ฆฐ ์์ฒ๊ฐ ๊ด์ฐฐ๋์์ต๋๋ค. ์์ฒ๋ ์ธ์ฒ ๋ฐ ํ์๋์์ผ๋ฉฐ ์์กด ์ด๋ฌผ์ง์ ๋ฐ๊ฒฌ๋์ง ์์์ต๋๋ค. ํ์ํ ์๋ฐฉ ์ ์ข
์ด ์ํ๋์์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์ ์ ํ ์ฒ์น๋ ๋ฌด์์
๋๊น? | Administer amoxicillin-clavulanic acid | {
"A": "amoxicillin-clavulanic acid ํฌ์ฌ",
"B": "trimethoprim-sulfamethoxazole ํฌ์ฌ",
"C": "๋ดํฉ์ผ๋ก ์์ฒ๋ฅผ ๋ซ๊ณ ํ์๋ฅผ ํด์์ํด",
"D": "์ธ๋ ์ง๋ฃ๋ฅผ ์์ฝํ๊ณ ํ์๋ฅผ ํด์์ํด"
} | step2&3 | A | [
"27 year old man presents",
"emergency department",
"dog bite",
"patient",
"pulled",
"dogs tail",
"eating",
"dog",
"friend",
"back",
"friends house currently",
"Physical exam",
"notable",
"dog bite",
"patients right arm",
"wound",
"irrigated",
"retained bodies found",
"tetanus vaccination",
"administered",
"following",
"appropriate management",
"patient"
] | 00000000000000000033 |
19์ธ ์ฌ์ฑ์ด ๋ถ๋ชจ์ ๋๋ฐํ์ฌ 1์ฃผ์ผ๊ฐ์ ๋น์ ์์ ์ธ ํ๋, ๋ง์ ๋ฐ ํน์ดํ ๊ณต๊ฒฉ์ฑ์ ํธ์ํ๋ฉฐ ๋ด์ํ์ต๋๋ค. ๋ฐ์ด, ๋ฐ์ ๋๋ ๋ถ๋ฒ ์ฝ๋ฌผ ์ฌ์ฉ์ ๋ถ์ธํฉ๋๋ค. ๊ฐ์กฑ๋ ฅ์์ ์ ์ ์งํ์ ์์ต๋๋ค. ๊ทธ๋
๋ risperidone ๋ณต์ฉ์ ์์ํ๊ณ ๋ถ๋ชจ์ ํจ๊ป ์ง์ผ๋ก ๋์๊ฐ์ต๋๋ค. 3์ผ ํ, ๊ทธ๋
๋ ๋ฐ์ด๊ณผ ํผ๋์ผ๋ก ์๊ธ์ค์ ์ด์ก๋์์ต๋๋ค. ๊ทธ๋
๋ ๋ง๋ก ๋ฐ์ํ์ง ์์ต๋๋ค. ๋ณ์์์ ๊ทธ๋
์ ์ฒด์จ์ 39.8ยฐC (103.6ยฐF), ํ์์ 100/60 mm Hg, ๋งฅ๋ฐ์๋ 102/๋ถ, ํธํก์๋ 16/๋ถ์
๋๋ค. ๊ทธ๋
๋ ๋์ ๋งค์ฐ ๋ง์ด ํ๋ฆฌ๊ณ ๋ปฃ๋ปฃํด ๋ณด์
๋๋ค. ๊ทธ๋
๋ ์๋ฐ์ ์ผ๋ก ๋์ ๋จ์ง๋ง ๋ง๋ก ๋ฐ์ํ์ง ์๊ณ ๋ช
๋ น์ ๋ฐ๋ฅด์ง ์์ต๋๋ค. ์คํ์ค ์ฐ๊ตฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค.
Sodium 142 mmol/L
Potassium 5.0 mmol/L
Creatinine 1.8 mg/dl
Calcium 10.4 mg/dl
Creatine kinase 9800 U/L
White blood cells 14,500/mm3
Hemoglobin 12.9 g/dl
Platelets 175,000/mm3
์๋ณ ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋จ๋ฐฑ์ง 1+, ํค๋ชจ๊ธ๋ก๋น 3+์ด๋ฉฐ ๊ฐ๋ ๋ฐฑํ๊ตฌ๊ฐ ์๊ณ ์ ํ๊ตฌ ์์ฃผ๊ฐ ์์ต๋๋ค. ์ด ์ํ๋ฅผ ๊ด๋ฆฌํ๋ ๋ฐ ๊ฐ์ฅ ์ข์ ์ฒซ ๋ฒ์งธ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Stop risperidone | {
"A": "Intravenous hydration",
"B": "Paracetamol",
"C": "Stop risperidone",
"D": "Switch risperidone to clozapine"
} | step2&3 | C | [
"year old woman",
"parents",
"presents",
"one-week history",
"abnormal behavior",
"delusions",
"unusual aggression",
"denies fever",
"seizures",
"illicit drug use",
"Family history",
"negative",
"psychiatric illnesses",
"started",
"risperidone",
"sent home",
"parents",
"Three days later",
"brought",
"emergency department",
"fever",
"confusion",
"not",
"responsive",
"hospital",
"temperature",
"blood pressure",
"100 60 mm Hg",
"pulse rate",
"min",
"respiratory rate",
"min",
"extremely diaphoretic",
"appears stiff",
"spontaneous eye opening",
"not",
"responsive",
"not following commands",
"Laboratory studies show",
"Sodium",
"mmol",
"0 mmol",
"1 8 mg dl",
"mg dl Creatine",
"blood cells",
"500",
"Hemoglobin",
"g",
"Urinalysis shows protein 1",
"hemoglobin",
"occasional leukocytes",
"red blood casts",
"best first step",
"management",
"condition"
] | 00000000000000000034 |
35์ธ ์ฌ์ฑ์ด 1๊ฐ์ ๋์์ ๋ณต์, ๊ณ๋จ ์ค๋ฅด๊ธฐ์ ์ด๋ ค์, ๊ทธ๋ฆฌ๊ณ ๋จธ๋ฆฌ๋ฅผ ๋น์ผ๋ ค๊ณ ํ ๋์ ์ ์ฝ๊ฐ์ผ๋ก ์ธํด ์์ฌ๋ฅผ ์ฐพ์์ต๋๋ค. ๊ทธ๋
๋ ์ด๋ฌํ ์ฆ์๋ค์ด ์ด๋ ํ์ ๋ ์ฌํด์ง๊ณ ๋ช ์๊ฐ ๋์ ํด์์ ์ทจํ๋ฉด ์ฌ๋ผ์ง๋ค๊ณ ๋ณด๊ณ ํฉ๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ํ์๊ฐ 2๋ถ ๋์ ์ฒ์ฅ์ ์์ํ๋๋ก ์์ฒญ๋ฐ์์ ๋ ์
ํ๋๋ ์ค๋ฅธ์ชฝ ์ ๋๊บผํ ์ฒ์ง์ด ๊ด์ฐฐ๋ฉ๋๋ค. ์์ง์์ ์ด๋๋ ฅ์ด ๊ฐ์๋์์ต๋๋ค. ๋๋จธ์ง ๊ฒ์ฌ์์๋ ์ด์์ด ์์ต๋๋ค. ๋ค์ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Myasthenia gravis | {
"A": "Myasthenia gravis",
"B": "Polymyositis",
"C": "Amyotrophic lateral sclerosis",
"D": "Multiple sclerosis"
} | step1 | A | [
"35 year old woman",
"physician",
"month history",
"double vision",
"difficulty climbing stairs",
"weakness",
"to brush",
"hair",
"reports",
"symptoms",
"worse",
"exercises",
"rests",
"hours",
"Physical examination shows drooping",
"right upper eyelid",
"worsens",
"patient",
"to gaze",
"2 minutes",
"diminished motor strength",
"upper extremities",
"examination shows",
"abnormalities",
"following",
"most likely diagnosis"
] | 00000000000000000035 |
์์์์์ ์ต๊ทผ ๋ฏธ๊ตญ์ผ๋ก ์ด๋ฏผ ์จ 6์ธ ๋จ์๊ฐ ํธํก๊ณค๋์ผ๋ก ์
์ํ์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ํ์์ ๊ตฌ๊ฐ ์ธ๋์ ํ์ ์๋ง๊ณผ ๋ฆผํ์ ๋ณ์ฆ์ด ๋ํ๋ฌ์ต๋๋ค. ํ์๋ ์ฌ๊ทผ์ผ์ ์๋ค๊ฐ ์
์ 5์ผ์งธ ์ฌ๋งํ์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์ฆ์ ๋ฐํ๊ณผ ์
ํ๋ฅผ ์๋ฐฉํ ์ ์์๋ ๊ฒ์ ๋ฌด์์ด์์๊น์? | Circulating IgG against AB exotoxin | {
"A": "CD4+ T ์ธํฌ ์ ์ฆ๊ฐ",
"B": "๋ฐ์ด๋ฌ์ค ๋จ๋ฐฑ์ง์ ๋ํ ๋ถ๋นํ IgA",
"C": "์ธ๊ท ์นจ์
์ ๋ง๋ IgM ์ฆ๊ฐ",
"D": "AB ์ธ๋
์์ ๋ํ ์ํ IgG"
} | step1 | D | [
"year old male",
"recently",
"United States",
"Asia",
"admitted",
"hospital",
"dyspnea",
"Physical exam reveals",
"gray pseudomembrane",
"patient's oropharynx",
"lymphadenopathy",
"patient",
"myocarditis",
"expires",
"hospital day 5",
"following",
"prevented",
"patient's presentation"
] | 00000000000000000036 |
์ต๊ทผ ํํค์คํ์์ ์ด๋ฏผ ์จ 12์ธ ๋จ์์์ด๊ฐ ๋ฐ์ด, ๊ทผ์กํต, ๋ชธํต, ๋ณต๋ถ ๋ฐ ๋ค๋ฆฌ ์ ์ฝ ์ฆ์์ผ๋ก ๋ด์ํ์ต๋๋ค. ํ์์ ์ด๋จธ๋๋ ์์ด๊ฐ ์๋ฐฉ ์ ์ข
์ ๋ฐ์ง ์์๋ค๊ณ ๋งํฉ๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ํ์ง์ ์ฌ์ ์์ฑ ์์ถ ๋ฐ ์ด์์ฑ ๋ง๋น๊ฐ ๋ํ๋ฉ๋๋ค. ๋์ฒ์์ก(CSF) ๋ถ์ ๊ฒฐ๊ณผ, ์ ์์ ์ธ ํฌ๋๋น ๋ฐ ๋จ๋ฐฑ์ง ์์น์ ํจ๊ป ๋ฆผํ๊ตฌ ์ฆ๊ฐ์ฆ์ด ๋ํ๋ฌ์ต๋๋ค. ์ธํ ๋ฉด๋ด ๊ฒ์ฌ์์ RNA virus๊ฐ ๊ฒ์ถ๋์์ต๋๋ค. ์ด ํ์์์ ๋ฐ์ด๋ฌ์ค์ ์ํด ๊ฐ์ฅ ํ๊ดด๋ ๊ฐ๋ฅ์ฑ์ด ๋์ ๊ฒ์ ๋ค์ ์ค ๋ฌด์์
๋๊น? | Anterior horn of the spinal cord | {
"A": "Posterior horn cells of the spinal cord",
"B": "Myelin sheath of neurons",
"C": "Muscle cells",
"D": "Anterior horn of the spinal cord"
} | step1 | D | [
"year old boy",
"recently",
"Pakistan presents",
"fever",
"muscle pain",
"weakness",
"trunk",
"abdomen",
"legs",
"patients mother",
"not",
"vaccinated",
"Physical examination reveals fasciculation",
"flaccid paralysis of",
"lower limbs",
"CSF analysis reveals lymphocytosis",
"normal glucose",
"protein levels",
"throat swab reveals",
"RNA virus",
"following",
"most likely",
"destroyed",
"virus",
"patient"
] | 00000000000000000037 |
ํ ์ฐ๊ตฌ์๊ฐ ํฌ์คํ์ดํธ ๊ทธ๋ฃน์ ๊ธ๋ฃจ์ฝ์ค์ ์ถ๊ฐํ๋ ํจ์์ ํน์ฑ์ ์ฐ๊ตฌํ๊ณ ์์ต๋๋ค. ๊ทธ๋
๋ ๊ทธ ํจ์๊ฐ ๋๋ถ๋ถ์ ์ ์ฒด ์กฐ์ง์ ์กด์ฌํ๋ฉฐ ํจ์๋ฅผ ๋ฐํํ๋ ์ธํฌ์ ์ธํฌ์ง์ ์์นํ๋ค๋ ๊ฒ์ ๋ฐ๊ฒฌํฉ๋๋ค. ๊ทธ๋
๋ ์ด ํจ์๋ฅผ ์์๋ฆฌ์ ์กฐ๊ฑด ํ์์ ๋ค์ํ ์์ค์ glucose์ ํผํฉํ์ฌ ํจ์์ ๋์ญํ์ ํน์ฑ์ ๊ฒฐ์ ํ๊ธฐ๋ก ๊ฒฐ์ ํฉ๋๋ค. ๊ตฌ์ฒด์ ์ผ๋ก, ๊ทธ๋
๋ ํฌ์คํ์ดํธ์ ํฌํ ๋๋์์ ์ฆ๊ฐํ๋ ์์ค์ glucose๋ฅผ ์ฒจ๊ฐํ๊ณ glucose๊ฐ ์ธ์ฐํ๋๋ ์๋๊ฐ ๋ ๋์ ์์ค์ glucose์์ ๋ ๋นจ๋ผ์ง๋ ๊ฒ์ ํ์ธํฉ๋๋ค. ๊ทธ๋
๋ ์ด ์๋๊ฐ ์ต๋ ์๋์ ์ ๊ทผํ๋ ๊ฒ์ ๊ด์ฐฐํ๊ณ ์ด ์๋๋ฅผ Y๋ผ๊ณ ๋ถ๋ฆ
๋๋ค. ๊ทธ๋ฐ ๋ค์ ํจ์๊ฐ ์๋ Y์ ์ ๋ฐ์ผ๋ก ๊ธฐ๋ฅํ๋ ๋ฐ ํ์ํ glucose์ ๋๋๋ฅผ ๊ฒฐ์ ํ๊ณ ์ด ๋๋๋ฅผ X๋ผ๊ณ ๋ถ๋ฆ
๋๋ค. ๋ค์ ์ค ์ด ํจ์์ ํน์ฑ์ ๋ํด ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ๊ฒ์ ๋ฌด์์
๋๊น? | Low X and low Y | {
"A": "High X and high Y",
"B": "High X and low Y",
"C": "Low X and high Y",
"D": "Low X and low Y"
} | step1 | D | [
"researcher",
"studying",
"properties",
"enzyme",
"adds phosphate groups",
"glucose",
"discovers",
"enzyme",
"present",
"body tissues",
"cytoplasm",
"cells",
"enzyme",
"to mix",
"enzyme",
"conditions",
"levels",
"glucose",
"order to",
"kinetic properties",
"enzyme",
"adds increasing levels",
"glucose",
"saturating concentration",
"phosphate",
"sees",
"rate",
"glucose",
"gets faster",
"higher levels",
"glucose",
"observes",
"rate approaches",
"maximum speed",
"calls",
"speed",
"then",
"concentration",
"glucose",
"needed to make",
"enzyme function",
"half",
"speed",
"calls",
"concentration",
"following",
"most likely true",
"properties",
"enzyme"
] | 00000000000000000038 |
์์ 40์ฃผ์ฐจ์ 31์ธ G2P2 ์ฌ์ฑ ํ์๊ฐ ์ง์์ ๋ฌผ์ด ํฐ์ ธ ๋ณ์์ ๋ด์ํ์ต๋๋ค. ์๊ถ ๊ฒฝ๋ถ๋ 4cm ์ด๋ฆฌ๊ณ 80% ์์ค๋์์ต๋๋ค. ํ์ ์ฌ๋ฐ์ ์ถ์ ๊ฒฐ๊ณผ ๋ถ๋น 155ํ ๋ฐ๋์์ ๋ณ๋์ฑ ๊ฐ์์ด ๊ด์ฐฐ๋์์ต๋๋ค. ๋ด์ ํ ์ฝ 12์๊ฐ ๋ค, 6ํ์ด๋ 15์จ์ค์ ๋จ์์์ด๋ฅผ ์ถ์ฐํ์ผ๋ฉฐ, ์ํ๊ฐ ์ ์๋ 1๋ถ ๋ฐ 5๋ถ์ ๊ฐ๊ฐ 8์ ๊ณผ 9์ ์ ๋ฐ์์ต๋๋ค. ๋ค์ ๊ตฌ์กฐ ์ค ์ฌ์ฑ ๋ด๋ถ ์์๊ธฐ์ ์ต์ ๋ฅผ ๋ด๋นํ๋ ๊ฒ์ ๋ฌด์์
๋๊น? | Sertoli cells | {
"A": "Spermatogonia",
"B": "Allantois",
"C": "Syncytiotrophoblast",
"D": "Sertoli cells"
} | step1 | D | [
"31 year old",
"female",
"40 weeks presents",
"hospital following",
"rush",
"water",
"vagina",
"4",
"dilated",
"80",
"Fetal heart",
"shows",
"pulse",
"min",
"variable decelerations",
"12 hours",
"presentation",
"gives birth",
"oz baby boy",
"APGAR scores",
"8",
"5 minutes",
"following structures",
"responsible",
"inhibition",
"female internal genitalia"
] | 00000000000000000039 |
43์ธ ์ฌ์ฑ์ด ์ฌ๊ณํญ์ง, ๋ง๋ฅธ ๊ธฐ์นจ, ๊ทธ๋ฆฌ๊ณ 1์ฃผ์ผ ๋์์ ์จ๊ฐ์จ์ ํธ์ํ๋ฉฐ ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ๊ทธ๋
๋ 20์ธ์ ํ๊ตญ์์ ๋ฏธ๊ตญ์ผ๋ก ์ด๋ฏผ ์์ต๋๋ค. ๊ทธ๋
๋ ์ฌ์ฅ์ด ๋น ๋ฅด๊ฒ ๋ฐ๊ณ ์์ผ๋ฉฐ ์ด์ ์๋ ์ด๋ฌํ ์ฆ์์ ๋๊ปด๋ณธ ์ ์ด ์๋ค๊ณ ๋งํฉ๋๋ค. ๊ทธ๋
์ ๊ธฐ์นจ์ ๋ง๋ฅธ ๊ธฐ์นจ์ด๋ฉฐ ์ต์ํ์ ๋
ธ๋ ฅ์ผ๋ก ๋ฐ์ํ๋ ์จ๊ฐ์จ๊ณผ ๊ด๋ จ์ด ์์ต๋๋ค. ๊ทธ๋
์ ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ ๊ทธ ์ธ์๋ ํน์ด์ฌํญ์ด ์์ต๋๋ค. ๊ทธ๋
๋ ์๋ ๋ฅด๊ธฐ๊ฐ ์๊ณ ํ์ฌ ๋ณต์ฉ ์ค์ธ ์ฝ๋ฌผ๋ ์์ต๋๋ค. ๊ทธ๋
๋ ๋นํก์ฐ์์ด๋ฉฐ ๊ฐ๋ ์ ์ ๋ง์ญ๋๋ค. ๊ทธ๋
๋ ๋ถ๋ฒ ์ฝ๋ฌผ ์ฌ์ฉ์ ๋ถ์ธํฉ๋๋ค. ๊ทธ๋
์ ํ์์ 100/65 mm Hg, ๋งฅ๋ฐ์ 76/๋ถ, ํธํก์๋ 23/๋ถ, ์ฒด์จ์ 36.8ยฐC (98.2ยฐF)์
๋๋ค. ๊ทธ๋
์ ์ ์ฒด ๊ฒ์ฌ์์๋ ์์ชฝ ํ ํ๋ถ์์ ํ๋ ด๊ท ์์ด ๋ค๋ฆฌ๊ณ , ๋ฐฉ์ฌ๋์ง ์๊ณ , ๋ฎ์ ์์กฐ์, ์ฌ์ฅ ์ค๊ฐ ์ด์๊ธฐ ์ง๋์ฑ ์ก์์ด ์ฌ์ฒจ๋ถ ์์ญ์์ ๊ฐ์ฅ ์ ๋ค๋ฆฝ๋๋ค. ๋ํ, ๊ทธ๋
๋ ๋ชฉ์ ๋งฅ ํฝ์ฐฝ๊ณผ ํ์ง์ ์์ธก์ฑ ํจ์ ๋ถ์ข
์ ๊ฐ์ง๊ณ ์์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์ํ๋ฅผ ์ ๋ฐํ ๊ฐ์ผ์ฑ ๋ฌผ์ง์ ๊ฐ์ฅ ์ ์ค๋ช
ํ๋ ๊ฒ์ ๋ฌด์์
๋๊น? | A bacterium that induces complete lysis of the red cells of a blood agar plate with an oxygen-sensitive cytotoxin | {
"A": "hydrogen peroxide๋ก ์ ํ๊ตฌ์ ๋ถ๋ถ ์ฉํด๋ฅผ ์ ๋ํ๋ ๋ฐํ
๋ฆฌ์",
"B": "์ฐ์์ ๋ฏผ๊ฐํ ์ธํฌ ๋
์๋ก ํ์ก ํ์ฒ ๋ฐฐ์ง์ ์ ํ๊ตฌ์ ์์ ์ฉํด๋ฅผ ์ ๋ํ๋ ๋ฐํ
๋ฆฌ์",
"C": "ํ์ก ํ์ฒ ๋ฐฐ์ง์ ์ ํ๊ตฌ์ ํด ๋ถํด๋ฅผ ์ ๋ํ๋ ๋ฐํ
๋ฆฌ์",
"D": "์ ๋๋ก ์ฑ์ฅํ๋ ค๋ฉด ํ๊ธฐ์ฑ ํ๊ฒฝ์ด ํ์ํ ๋ฐํ
๋ฆฌ์"
} | step1 | B | [
"year old woman presents",
"emergency department",
"palpitations",
"dry cough",
"shortness of breath",
"1 week",
"United States",
"Korea",
"age",
"20",
"heart",
"racing",
"never felt",
"symptoms",
"cough",
"dry",
"associated with shortness of breath",
"occurs",
"minimal exertion",
"past medical history",
"unremarkable",
"allergies",
"not currently taking",
"medications",
"nonsmoker",
"occasional drinker",
"denies illicit drug use",
"blood pressure",
"100 65 mm Hg",
"pulse",
"76 min",
"respiratory rate",
"23 min",
"temperature",
"36",
"98",
"physical examination",
"significant",
"lung crackles",
"non radiating",
"low-pitched",
"mid-diastolic rumbling murmur best heard",
"apical region",
"addition",
"jugular vein distention",
"bilateral pitting edema",
"lower extremities",
"following best",
"infectious agent",
"led",
"patients condition"
] | 00000000000000000040 |
ํ ๋จ์ ์ ์์๊ฐ ์์๊ณผ ์์ฌ์๊ฒ ์ง์ฐฐ์ ๋ฐ๊ณ ์์ต๋๋ค. ๊ทธ์ ์ด๋จธ๋๋ ์์ฌ์๊ฒ ์์ 2๊ฐ์ ๋์ ๊ฐ๋ฒผ์ด ๋ฐ์ด๊ณผ ๋ฐ์ง, ๊ทผ์กํต, ๋ถ์ด์ค๋ฅด๊ณ ์ํ ๋ฆผํ์ ์ด ์์๋ค๊ณ ์๋ฆฝ๋๋ค. ๊ทธ ์์ด๋ ์ฐ์ ๊ด๋ฆฌ๋ฅผ ๋ฐ์ง ์๊ณ 39์ฃผ ์์ ๊ธฐ๊ฐ์ ์์ฐ ์ง์ ๋ถ๋ง์ผ๋ก ํ์ด๋ฌ์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ์ ์์๋ ์ ์์ ์ธ ํ๋ ฅ ์งํ๋ฅผ ๋ณด์
๋๋ค. ๋ง๋ง ๊ฒ์ฌ์์ ์ด๋ฏธ์ง์ ํ์๋ ์๊ฒฌ์ด ๋ํ๋ฉ๋๋ค. ๋ค์ ์ค ์ด ์ ์์์๊ฒ ๊ฐ์ฅ ํํ๊ฒ ๋ํ๋ ์ ์๋ ์ ์ฒ์ฑ ์ฌ์ฅ ๊ฒฐํจ์ ๋ฌด์์
๋๊น? | Patent ductus arteriosus | {
"A": "Atrial septal defect",
"B": "Ventricular septal defect",
"C": "Tetralogy of Fallot",
"D": "Patent ductus arteriosus"
} | step2&3 | D | [
"male neonate",
"examined",
"pediatrician",
"mother informs",
"doctor",
"mild fever with rash",
"muscle pain",
"swollen",
"tender lymph nodes",
"second month",
"gestation",
"boy",
"born",
"weeks gestation",
"spontaneous vaginal delivery",
"prenatal care",
"physical examination",
"neonate",
"normal vital signs",
"Retinal examination reveals",
"findings shown",
"image",
"following congenital heart defects",
"most likely to",
"present",
"neonate"
] | 00000000000000000041 |
4์ธ ๋จ์์์ด๊ฐ ๋ถ๋ชจ์ ์ํด ์๊ธ์ค๋ก ์ด์ก๋์์ต๋๋ค. ์์ด๋ ๋ฌด๊ธฐ๋ ฅํ๊ณ ํผ๋์ค๋ฌ์ํ๋ฉฐ, ๊ทธ๋ ์ด๋ถํฐ ์ฌํ ๋ํต, ๊ตฌํ , ๊ณ ์ด์ ๋ณด์์ต๋๋ค. ๊ทธ์ ์ด๋จธ๋๋ ์ดํ ์ ๊น์ง ์์ด๊ฐ ๊ด์ฐฎ์๊ณ , ๊ทธ ์ดํ ๋ฐ์ด๊ณผ ๋
น์ ์ฝง๋ฌผ์ด ๋ฐ์ํ๋ค๊ณ ๋ณด๊ณ ํ์ต๋๋ค. ํ์๋ ์ ์์ ํจํ์ฆ, 18๊ฐ์์ ์๋ง๊ตฌ๊ท ํ์ฆ, 2์ธ์ 3์ธ์ ํ๋ ด ๋ณ๋ ฅ์ด ์์ต๋๋ค. ์์ ๋ ์๋ฐฉ ์ ์ข
์ ์๋ฃ๋์์ต๋๋ค. ํ์์ 70/50 mm Hg, ์ฌ๋ฐ์๋ 120/min, ํธํก์๋ 22/min, ์ฒด์จ์ 39.3ยฐC (102.4ยฐF)์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ์์ด๋ ๋ฌด๊ธฐ๋ ฅํ๊ณ ํผ๋ถ๋ ์ฐฝ๋ฐฑํ๋ฉฐ, ๋๋ถ์ ์ฌ๋ฌ ์ ์ ์ถํ์ด ์์ต๋๋ค. ์์ชฝ ์ฝง๊ตฌ๋ฉ์์ ํ๋์ฑ ์ฝง๋ฌผ์ด ๊ด์ฐฐ๋ฉ๋๋ค. ์์ชฝ ํ๋ ์ฒญ์ง ์ ๊นจ๋ํฉ๋๋ค. ์ฌ์์ ์ ์์
๋๋ค. ํ์ ํ ๊ฒฝ๋ถ ๊ฐ์ง์ด ์์ต๋๋ค. ๋์ฒ์์ก ๋ถ์ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค.
์ด๊ธฐ ์๋ ฅ 100 mm H2O
์ธ๊ด ํ๋ฆผ
๋จ๋ฐฑ์ง 500 mg/dL (5 g/L)
๋ฐฑํ๊ตฌ 2500/ฮผL (๋คํํต์ธํฌ ์ฐ์ธ)
๋จ๋ฐฑ์ง 450 mg/dL (4.5 g/L)
ํฌ๋๋น 31 mg/dL (1.7 mmol/L)
๋ฐฐ์ ๊ฒ์ฌ์์ N. meningitidis ์์ฑ
๋ค์ ๋ฉด์ญํ์ ๊ณผ์ ์ค ์ด ์์ด์๊ฒ์ ๊ฐ์ฅ ์์๋์์ ๊ฐ๋ฅ์ฑ์ด ๋์ ๊ฒ์ ๋ฌด์์
๋๊น? | Formation of C5-9 complex | {
"A": "Th1 ์ธํฌ์ ์ํ IL-2 ์์ฑ",
"B": "MHC-II์ ์ํ TCR ํ์ฑํ",
"C": "C5-9 ๋ณตํฉ์ฒด ํ์ฑ",
"D": "๋ณด์ฒด์ C2 ์ฑ๋ถ ๋ถํด๋ก C2a ๋ฐ C2b ์์ฑ"
} | step1 | C | [
"4 year old boy",
"brought",
"emergency department",
"parents",
"lethargic",
"confused",
"severe headache",
"vomiting",
"high-grade fever since earlier",
"day",
"mother reports",
"child",
"well",
"2 days",
"fever",
"green nasal discharge",
"patient",
"history of neonatal sepsis",
"meningococcemia",
"months",
"age",
"pneumococcal pneumonia",
"3 years",
"age",
"scheduled vaccinations",
"date",
"blood pressure",
"70 50 mm Hg",
"heart rate",
"min",
"respiratory rate",
"min",
"temperature",
"3C",
"4F",
"examination",
"child",
"lethargic",
"skin",
"pale",
"several petechiae",
"buttocks",
"purulent nasal discharge",
"nostrils",
"lungs",
"clear",
"auscultation",
"Heart sounds",
"normal",
"marked neck rigidity",
"Cerebrospinal fluid analysis shows",
"following results",
"Opening pressure 100 mm H2O Appearance cloudy Protein 500 mg/dL",
"5 g/L",
"White blood cells 2500 L",
"predominance",
"Protein 450 mg/dL",
"4.5 g/L",
"Glucose 31 mg/dL",
"1.7 mmol/L",
"Culture positive",
"N",
"meningitidis",
"following immunological processes",
"most likely to",
"impaired",
"child"
] | 00000000000000000042 |
๋ง์ฑ ํ์์ฑ ํ์งํ์ ์๊ณ ์๋ 66์ธ ์ฌ์ฑ์ด ๋ฐ์ด, ๋ชธ์ด, ๊ถํ๊ฐ ๋ฐ ๋ง๋ฅธ ๊ธฐ์นจ์ผ๋ก ์ธํด ์๊ธ์ค๋ก ์ด์ก๋์์ต๋๋ค. ๊ทธ๋
๋ ๋งค์ผ ๋ด๋ฐฐ ํ ๊ฐ์ฉ 30๋
๋์ ํก์ฐํ์ง๋ง 1๋
์ ์ ๊ธ์ฐํ์ต๋๋ค. ๊ทธ๋
๋ ๋ฐ์ด์ผ์ด์ ๋ค๋๋ ๋ธ๊ณผ ์๋
์ ํจ๊ป ์ด๊ณ ์์ต๋๋ค. ์ฒด์จ์ 38.1ยฐC(101ยฐF)์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ์์ธก ๊ฒฐ๋ง์ผ, ์ฝง๋ฌผ ๋ฐ ์ผ์ถ๋ฌผ์ด ์๋ ํ๋ฐ์ฑ ํธ๋๊ฐ ๋ํ๋ฌ์ต๋๋ค. ์ถ๊ฐ ๊ฒ์ฌ ๊ฒฐ๊ณผ ์ธํผ๋ฅผ ๊ฐ์ง Orthomyxovirus ๊ฐ์ผ์ด ํ์ธ๋์์ต๋๋ค. ๋ค์ ์ค ์ด๋ค ์์ฉ ๊ธฐ์ ์ ๊ฐ์ง ์ฝ๋ฌผ ํฌ์ฌ๊ฐ ๊ฐ์ฅ ์ ์ ํฉ๋๊น? | Inhibition of neuraminidase | {
"A": "Inhibition of nucleoside reverse transcriptase",
"B": "Inhibition of proton translocation",
"C": "Inhibition of neuraminidase",
"D": "Inhibition of protease"
} | step1 | C | [
"66 year old woman",
"chronic obstructive pulmonary disease",
"brought",
"emergency department",
"fever",
"body aches",
"malaise",
"dry cough",
"smoked one pack",
"cigarettes daily",
"30 years",
"quit smoking 1 year",
"lives with",
"daughter",
"granddaughter",
"attends daycare",
"temperature",
"Physical examination shows bilateral conjunctivitis",
"rhinorrhea",
"erythematous tonsils",
"exudates",
"Further testing confirms infection",
"orthomyxovirus",
"Administration",
"drug",
"of",
"following mechanisms",
"action",
"most appropriate"
] | 00000000000000000043 |
38์ธ ์ฌ์ฑ ํ์๊ฐ ๊ตญ์์ ์ด๊ณ ๋ถํ๊ฐ ์ ๋ ์ ๋์ ๊ฐ์์ ์ ์น๋ฃ๋ฅผ ์ํด ๊ฐ์์ ๋ถ๋ถ ์ ์ ์ ์ ๋ฐ์ต๋๋ค. ๋ณ๋ณ์ ๊นจ๋ํ ์ ์ ์ฐ๊ณผ ํจ๊ป ์ ๊ฑฐ๋ฉ๋๋ค. ๊ทธ๋ฌ๋ ์์ ์ค ๊ฐ์์ ์ฝ ์๊ทน์์ ์๊ฐ์์ ๋๋งฅ์ ์ง์ ์ธ์ ํ ๊ตฌ์กฐ๋ฌผ์ด ์์๋ฉ๋๋ค. ์ด ํ์์๊ฒ ๋ํ๋ ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ๋์ ์ฆ์์ ๋ค์ ์ค ๋ฌด์์
๋๊น? | Voice pitch limitation | {
"A": "์์ฑ ๊ณ ์ ์ ํ",
"B": "๊ธฐ์นจ ๋ฌด๋ ฅ",
"C": "์ด๊นจ ์ผ์ฑ๊ฑฐ๋ฆผ ์ฝํ",
"D": "ํธํก ๊ณค๋"
} | step1 | A | [
"year old woman",
"hemithyroidectomy",
"treatment of localized",
"well-differentiated papillary thyroid carcinoma",
"lesion",
"removed",
"clear margins",
"surgery",
"structure lying directly adjacent to",
"superior thyroid artery",
"upper",
"thyroid lobe",
"damaged",
"patient",
"most likely to experience",
"following symptoms"
] | 00000000000000000044 |
27์ธ ๋จ์ฑ์ด ์ง๋ 3์ผ ๋์ ์ง์์ ์ธ ๋ฐ์ด, ๋ฉ์ค๊บผ์, ๊ตฌํ ์ฆ์์ผ๋ก ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ์ง๋ฃ๋ฅผ ๊ธฐ๋ค๋ฆฌ๋ ๋์ ๊ทธ๋ ๋น ๋ฅด๊ฒ ๋ฐฉํฅ ๊ฐ๊ฐ์ ์๊ณ ํฅ๋ถํฉ๋๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ, ๊ทธ๋ ํ๋ถํ ๊ตฌ๊ฐ ๋ถ๋น๋ฌผ๊ณผ ์ ๋ฐ์ ์ธ ๊ทผ์ก ๊ฒฝ๋ จ๊ณผ ํจ๊ป ํธํก ๊ณค๋์ ์งํ๋ฅผ ๋ณด์
๋๋ค. ํ์์ ์ฒด์จ์ 104ยฐF(40ยฐC), ํ์์ 90/64 mmHg, ๋งฅ๋ฐ์ 88/min, ํธํก์๋ 18/min์ด๋ฉฐ, ์ค๋ด ๊ณต๊ธฐ์์ ์ฐ์ ํฌํ๋๋ 90%์
๋๋ค. ๊ฐํธ์ฌ๊ฐ ๋น๊ฐ ์บ๋๋ผ๋ฅผ ์ฝ์
ํ๋ ค ํ์ ํ์๋ ๋๋ ค์ํ๋ฉฐ ๊ณต๊ฒฉ์ ์ธ ๋ฐ์์ ๋ณด์
๋๋ค. ํ์๋ ์ง์ ์ ๋ฅผ ํฌ์ฌ๋ฐ๊ณ ๊ธฐ๊ณ์ ํ๊ธฐ๋ฅผ ์ํํฉ๋๋ค. ๋ค์ ์ค ํ์์ ๊ฐ์ฅ ์ ๋ ฅํ ์ง๋จ์ ๋ํ ์ํ ์ธ์๋ ๋ฌด์์
๋๊น? | Spelunking | {
"A": "Contaminated beef",
"B": "Epiglottic cyst",
"C": "Mosquito bite",
"D": "Spelunking"
} | step2&3 | D | [
"27 year old man presents",
"emergency room",
"persistent fever",
"nausea",
"vomiting",
"past 3 days",
"waiting to",
"seen",
"disoriented",
"agitated",
"examination",
"visible signs",
"difficulty breathing",
"copious oral secretions",
"generalized muscle twitching",
"patients temperature",
"blood pressure",
"90 64 mmHg",
"pulse",
"88 min",
"respirations",
"18 min",
"oxygen saturation",
"90",
"room air",
"nurse",
"to place",
"nasal cannula",
"patient",
"fearful",
"combative",
"patient",
"sedated",
"placed",
"mechanical ventilation",
"following",
"a risk factor",
"patients",
"likely diagnosis"
] | 00000000000000000045 |
21์ธ ๋จ์ฑ์ด ์ง์ญ ๋์ฐ๋ฌผ ์งํ์ฅ์์ ๋ชฉ์ ์นผ์ ์ฐ๋ฆฐ ์์ฒ๋ฅผ ์
์ ํ ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ํ์๋ ๋ค๋ฅธ ๋ฉด์์๋ ๊ฑด๊ฐํ๋ฉฐ ํต์ฆ์ ํธ์ํ๊ณ ์์ต๋๋ค. ํ์๋ ์ค์ค๋ก ๋ณ๋ ฅ์ ์ ๊ณตํ ์ ์์ต๋๋ค. ์ฒด์จ์ 97.6ยฐF (36.4ยฐC), ํ์์ 120/84 mmHg, ๋งฅ๋ฐ์ 90/min, ํธํก์๋ 15/min, ์ค๋ด ๊ณต๊ธฐ์์ ์ฐ์ ํฌํ๋๋ 98%์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ์ค๋ฅธ์ชฝ ์ ์๋๊ธฐ ์๋ 1 cm ์ง์ ์ 3 cm ์ด์์ด ๊ด์ฐฐ๋ฉ๋๋ค. ํ์์ ํธํก์์ ๊นจ๋ํ๊ณ ๊ธฐ๋๋ฅผ ๋ณดํธํ๊ณ ์์ต๋๋ค. ํ์ฐฉ์์ด๋ ํธํก ๊ณค๋์ ๊ด์ฐฐ๋์ง ์์ต๋๋ค. ๋ค์ ์ค ์ด ํ์ ๊ด๋ฆฌ์ ๋ค์ ๋จ๊ณ๋ก ๊ฐ์ฅ ์ ์ ํ ๊ฒ์ ๋ฌด์์
๋๊น? | CT angiogram | {
"A": "CT angiogram",
"B": "Intubation",
"C": "Observation and blood pressure monitoring",
"D": "Surgical exploration"
} | step2&3 | A | [
"21-year-old man presents",
"emergency department",
"sustaining",
"stab",
"neck",
"local farmer's market",
"patient",
"healthy",
"pain",
"patient",
"able to",
"history",
"temperature",
"97",
"36 4C",
"blood pressure",
"84 mmHg",
"pulse",
"90 min",
"respirations",
"min",
"oxygen saturation",
"98",
"room air",
"Physical exam demonstrates",
"3",
"laceration 1",
"inferior",
"mastoid process",
"right side",
"patient's breath sounds",
"clear",
"airway",
"stridor",
"difficulty breathing",
"noted",
"following",
"most appropriate next step",
"management",
"patient"
] | 00000000000000000046 |
13์ธ ์๋
๊ฐ ๋ชฉ ์์ชฝ์ ๋ฉ์ด๋ฆฌ ํ๊ฐ๋ฅผ ์ํด ์๋ฃ๊ธฐ๊ด์ ๋ด์ํ์ต๋๋ค. ํ์๋ ํต์ฆ์ ์๋ค๊ณ ํ์ง๋ง, "์ผํฌ ๋ ์์ง์ฌ์" ๊ทธ ๋ฉ์ด๋ฆฌ๊ฐ ์ ๊ฒฝ ์ฐ์ธ๋ค๊ณ ๋งํฉ๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ์ค๊ณจ ์, ํ์
๊ณจ ์๋์ ์ ์ค์ ๊ฒฝ๋ถ ์ข
๊ดด๊ฐ ๋ํ๋ฌ์ต๋๋ค. ์ข
๊ดด๋ ์ต์ํ์ผ๋ก ์์ง์ด๋ฉฐ, ๋ฐ์ ์์ด ๋์๋๋ ๋๋์ด ์์ต๋๋ค. ํ์๋ ๋ฌด์ด์ด๋ฉฐ, ๋ชจ๋ ํ๋ ฅ ์งํ๋ ์์ ์ ์
๋๋ค. ์ ํ๊ตฌ ๊ณ์ฐ ๋ฐ ๊ฐ์์ ๊ธฐ๋ฅ ๊ฒ์ฌ๋ฅผ ์ํํ์ผ๋ฉฐ, ์ ์ ๋ฒ์ ๋ด์ ์์ต๋๋ค. ์ด ํ์์ ์ฆ์์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ์๋ ์์ธ์ ๋ฌด์์
๋๊น? | Cyst formation in a persistent thyroglossal duct | {
"A": "ํ ๊ธฐ์ ๋ถ์ ์ง์์ ์ธ ๊ฐ์์ ์กฐ์ง",
"B": "22q11 ์ ์ ์ ๊ฒฐ์ค",
"C": "์ง์์ ์ธ ๊ฐ์์ค๊ด ๋ด ๋ญํฌ ํ์ฑ",
"D": "๋ฆผํ์ ๋น๋"
} | step1 | C | [
"year old girl presents",
"medical office",
"evaluation",
"lump",
"front of",
"neck",
"patient denies pain",
"states",
"mass",
"moves",
"I swallow",
"physical examination reveals",
"midline neck mass",
"hyoid bone",
"level",
"mandible",
"mass",
"mobile",
"feels fluctuant",
"erythema",
"patient",
"afebrile",
"vital signs",
"stable",
"complete blood count",
"thyroid function tests",
"performed",
"normal limits",
"most likely cause",
"patients presentation"
] | 00000000000000000047 |
ํฌ๋ก ๋ณ ๋ณ๋ ฅ์ด ์๋ 35์ธ ์ฌ์ฑ์ด ํ์ ์ง๋ฃ๋ฅผ ์ํด ๋ด์ํ์ต๋๋ค. ๊ทธ๋
๋ ์ต๊ทผ ๊ฑท๋ ๋ฐ ์ด๋ ค์์ ๋๋ผ๊ธฐ ์์ํ๋ค๊ณ ๋งํฉ๋๋ค. ๊ทธ๋
๋ ์น๊ตฌ๋ค์ด ๊ทธ๋
๊ฐ ์ ์ทจํ ๊ฒ์ฒ๋ผ ๊ฑท๋ ๊ฒ ๊ฐ๋ค๊ณ ๋๋ดํ๋ค๊ณ ๋งํฉ๋๋ค. ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ 2๋
์ ์ ์ง๋จ๋ฐ์ ํฌ๋ก ๋ณ์ผ๋ก ์ค์ํ๋ฉฐ, ์ฅ ์ฆ์์ด ์ฌํด์ง๊ณ ๋ค๋ฅธ ์น๋ฃ๋ฒ์ ๋ฐ์ํ์ง ์์ ์ง๋ 1๋
๋์ natalizumab์ผ๋ก ๊ด๋ฆฌํ์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ๋ณดํ ๋ฐ ์ฌ์ง ์ด๋ ์ค์กฐ์ฆ์ด ๋ํ๋ฉ๋๋ค. ์ค๋ฅธ์ชฝ ํ์ ํ์ 4/5์
๋๋ค. ๋์ T1/T2 MRI๋ฅผ ์ฃผ๋ฌธํ์ฌ ๋ณด์ฌ์ค๋๋ค. ๋ค์ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Progressive multifocal encephalopathy (PML) | {
"A": "Sporadic Creutzfeldt-Jakob disease (sCJD)",
"B": "Variant Creutzfeldt-Jakob disease (vCJD)",
"C": "Subacute sclerosing panencephalitis (SSPE)",
"D": "Progressive multifocal encephalopathy (PML)"
} | step1 | D | [
"35 year old woman",
"history of Crohn disease presents",
"follow-up appointment",
"started",
"difficulty walking",
"friends",
"joked",
"appears to",
"walking",
"drunk",
"Past medical history",
"significant",
"Crohn disease diagnosed 2 years",
"managed",
"natalizumab",
"past year",
"intestinal symptoms",
"severe",
"unresponsive",
"therapies",
"physical examination",
"gait",
"limb ataxia present",
"Strength",
"4/5",
"right upper limb",
"T1 T2 MRI of",
"brain",
"ordered",
"shown",
"following",
"most likely diagnosis"
] | 00000000000000000048 |
๋ง์ง๋ง ์๋ฆฌ์ผ์ ๊ธฐ์ค์ผ๋ก ์์ 10์ฃผ์ฐจ์ 23์ธ G1 ์ฌ์ฑ์ด ๊ฐ์์ค๋ฌ์ด ์ง ์ถํ๋ก ์ธํด ๋จํธ๊ณผ ํจ๊ป ์๊ธ์ค๋ก ์ด์ก๋์์ต๋๋ค. ํ์๋ ๊ฒฝ๋ฏธํ ํ๋ณต๋ถ ๊ฒฝ๋ จ์ด ์๊ณ ์ด์ง๋ฝ๊ณ ์ ์ฝํ๋ค๊ณ ํธ์ํฉ๋๋ค. ํ์์ 100/60 mm Hg์ด๊ณ , ๋งฅ๋ฐ์ 100ํ/๋ถ์ด๋ฉฐ, ํธํก์๋ 15ํ/๋ถ์
๋๋ค. ํ์๋ ์ง๋ 3์ผ ๋์ ๊ฐ๋ฒผ์ด ์ถํ์ด ์์์ง๋ง, ์ค๋์ ์ถํ์ด ํ์ ํ๊ฒ ์ฆ๊ฐํ๊ณ ํ์ ๋ฐฐ์ถ๋ ํ์ธํ๋ค๊ณ ํฉ๋๋ค. ์ค๋ ์์นจ ์ดํ๋ก ์ธ ๊ฐ์ ํจ๋๋ฅผ ๊ต์ฒดํ๋ค๊ณ ํฉ๋๋ค. ๋ํ ์ง๋ ๋ฉฐ์น ๋์ ๊ฒฝํํ๋ ๋ฉ์ค๊บผ์์ด ๊ฐ๋ผ์์๋ค๋ ๊ฒ์ ์์์ฐจ๋ ธ์ต๋๋ค. ์์ฌ๊ฐ ํ์๋ฅผ ์ง์ฐฐํ ๊ฒฐ๊ณผ, ์๊ถ ๊ฒฝ๊ด ๊ตฌ๋ฉ์ด ์ด๋ ค ์๊ณ ์ง์ ํ์ก์ด ๊ณ ์ฌ ์๋ ๊ฒ์ ํ์ธํ์ต๋๋ค. ์์ ์ฐ๋ฌผ์ด ์๊ถ ๊ฒฝ๊ด ๊ตฌ๋ฉ์์ ๊ด์ฐฐ๋ฉ๋๋ค. ํ์๋ ํก์ธ ์ํ์ ์ ์ค๋นํฉ๋๋ค. ๋ค์ ์ค ์์ ์์ค์ ๊ฐ์ฅ ์ ๋ ฅํ ์์ธ์ ๋ฌด์์
๋๊น? | Chromosomal abnormalities | {
"A": "Rh ๋ฉด์ญ",
"B": "ํญ์ธ์ง์ง ์ฆํ๊ตฐ",
"C": "์ผ์์ฒด ์ด์",
"D": "์ธ์"
} | step2&3 | C | [
"23 year old G1",
"10 weeks based",
"last menstrual period",
"brought",
"emergency department",
"husband due to sudden vaginal bleeding",
"mild lower abdominal cramps",
"feeling dizzy",
"weak",
"blood pressure",
"100 60 mm Hg",
"pulse",
"100 min",
"respiration rate",
"min",
"light spotting",
"3 days",
"today",
"bleeding increased markedly",
"passage",
"clots",
"changed three pads",
"morning",
"nausea",
"experiencing",
"past",
"days",
"physician",
"notes",
"cervical os",
"open",
"blood",
"pooling",
"vagina",
"Products of conception",
"visualized",
"os",
"patient",
"prepared",
"suction curettage",
"following",
"most likely cause",
"pregnancy loss"
] | 00000000000000000049 |
8๊ฐ์ ๋ ๋จ์์์ด๊ฐ ์ด๋จธ๋์ ์ํด ์ง๋ฃ์ค๋ก ์ด์ก๋์๋ค. ์ด๋จธ๋๋ ์์ด๊ฐ ๋งค์ฐ ๋ณด์ฑ๊ณ ์ต๊ทผ์ ์์ ๋ฅผ ํ์ง ์์๋ค๊ณ ์ง์ ํ๋ค. ์ด๋จธ๋๋ ์์ด๊ฐ ์์ ๋ฅผ ์ํ์ง ๋ชปํ๋๋ฐ๋ ๋ถ๊ตฌํ๊ณ ์ฒด์ค์ด ์ฆ๊ฐํ๊ณ ์๋ค๊ณ ์๊ฐํ๋ค. ์์ด๋ 39์ฃผ ์์ ์ ์ง์ ๋ถ๋ง์ผ๋ก ํฉ๋ณ์ฆ ์์ด ํ์ด๋ฌ๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ์์ด๋ ์ด๋จธ๋ ํ์์ ์ธ๊ณ ์๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ์ฒญ์์ฆ์ ์ฆ๊ฑฐ๋ ์์ผ๋ฉฐ, ์ฌ์ฅ ๊ฒ์ฌ๋ ์ ์ ๋ฒ์ ๋ด์ ์๋ค. ๋ณต๋ถ๋ฅผ ์ด์งํ ๋ ์ธ์์ด ์ฌํด์ง๋ค. ๋ณต๋ถ๋ ์ผ์ชฝ ํ๋ถ ์ฌ๋ถ๋ฉด์์ ๊ณ ์ฐฝ๊ณผ ํจ๊ป ํฝ๋ง๋์ด ์๋ค. ํน์ ์ธํฌ์ ์ด๋ ์คํจ๋ก ์ธํ ์งํ์ ์์ฌํ๋ค. ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์ธ๊ฐ? | Hirschsprung disease | {
"A": "๋ฉ์ผ ๊ฒ์ค",
"B": "๋์กฐ์ง ์ฆํ๊ตฐ",
"C": "์ญ์ด์ง์ฅ ํ์",
"D": "ํ๋ฅด์ฌ์คํ๋ฃฝ๋ณ"
} | step1 | D | [
"month old boy",
"brought",
"medical office",
"mother",
"mother states",
"boy",
"very fussy",
"not",
"feeding recently",
"mother thinks",
"baby",
"gaining weight",
"not feeding well",
"boy",
"delivered",
"weeks gestation",
"complications",
"physical examination",
"boy",
"noted to",
"crying",
"mothers arms",
"evidence",
"cyanosis",
"cardiac examination",
"normal limits",
"crying",
"abdomen",
"palpated",
"abdomen",
"distended",
"tympany",
"left lower quadrant",
"suspect",
"condition caused",
"failure",
"specialized cells to migrate",
"most likely diagnosis"
] | 00000000000000000050 |
60์ธ ๋จ์ฑ์ด ๋ณดํ ์ค ๋ค๋ฆฌ ํต์ฆ์ผ๋ก ์ธํด ์๋ฃ๊ธฐ๊ด์์ ์ง์ฐฐ์ ๋ฐ๊ณ ์ ํฉ๋๋ค. ๊ทธ๋ ํต์ฆ์ด ๋๋ถ์์ ์์ํ์ฌ ํ๋ฒ
์ง๋ก ํ์ฅ๋๊ณ ์ข
์๋ฆฌ๊น์ง ๋ด๋ ค๊ฐ๋ค๊ณ ๋งํฉ๋๋ค. ์ด์ ์๋ ํด์์ ์ทจํ๋ฉด ํต์ฆ์ด ์ํ๋์์ง๋ง ํ์ฌ๋ ํด์ ์ค์๋ ๋ฐ์ ํต์ฆ์ด ์ง์๋ฉ๋๋ค. ๊ทธ์ ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ diabetes mellitus, hypertension, ๊ทธ๋ฆฌ๊ณ ํก์ฐ์ผ๋ก ์ค์ํฉ๋๋ค. ํ๋ ฅ ์งํ๋ ์ ์ ๋ฒ์ ๋ด์ ์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ์์ธก ๋ชจ๋ฐ ์์ค๊ณผ ํจ๊ป ์์ถ๋ ๋ค๋ฆฌ๊ฐ ๊ด์ฐฐ๋ฉ๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์ํ์ ๊ฐ์ฅ ์ ๋ ฅํ ์์ธ์ ๋ฌด์์
๋๊น? | Narrowing and calcification of vessels | {
"A": "Decreased permeability of endothelium",
"B": "Narrowing and calcification of vessels",
"C": "Peripheral emboli formation",
"D": "Weakening of vessel wall"
} | step1 | B | [
"60 year old man",
"evaluation",
"medical office",
"leg pain",
"walking",
"pain starts",
"buttocks",
"extends",
"thighs",
"calves",
"pain resolved",
"rest",
"pain now",
"feet",
"rest",
"past medical history",
"significant",
"diabetes mellitus",
"hypertension",
"cigarette smoking",
"vital signs",
"normal limits",
"physical examination shows",
"atrophied leg",
"bilateral loss",
"following",
"most likely cause",
"patients condition"
] | 00000000000000000051 |
52์ธ ๋จ์ฑ์ด ๊ฐ์ด ํต์ฆ์ด ์ผ์ชฝ ํฑ๊ณผ ํ๋ก ๋ฐฉ์ฌ๋๋ ์ฆ์์ผ๋ก ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ๊ทธ๋ ๋๊ตฌ๋ฅผ ํ ๋ ๋น์ทํ ์ฆ์์ ๊ฒฝํํ๋ค๊ณ ๋งํฉ๋๋ค. ๋ณ๋ ฅ์ ๋น๋จ๋ณ, ๊ณ ํ์, ์์๋ ์ญ๋ฅ ์งํ(GERD)์ผ๋ก, ๊ฐ๊ฐ ๋ฉํธํฌ๋ฅด๋ฏผ, ํ๋๋กํด๋ก๋กํฐ์์ง๋, ํํ ํ๋ผ์กธ์ ๋ณต์ฉํ๊ณ ์์ต๋๋ค. ํ์์ 150/90 mm Hg, ๋งฅ๋ฐ์ 100/min, ํธํก์๋ 15/min์
๋๋ค. ์ฌ์ ๋(ECG)๋ V3-V6 ์ ๋์์ ST ๋ถ์ ์์น์ ๋ณด์
๋๋ค. ๊ทธ๋ ๊ธ์ฑ ์ฌ๊ทผ ๊ฒฝ์(MI)์ผ๋ก ์
์ํ์ฌ ์น๋ฃ๋ฅผ ์์ํ์ต๋๋ค. ๋ค์ ๋ ๊ทธ๋ ์ด์ง๋ผ์ฆ๊ณผ ํ๋ฆฐ ์์ผ๋ฅผ ํธ์ํ์ต๋๋ค. ๋ฐ๋ณต ํ๋ ฅ ์งํ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค: ํ์ 90/60 mm Hg, ๋งฅ๋ฐ 72/min, ํธํก์ 12/min. ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค:
ํ์ฒญ ํํ ๊ฒ์ฌ
๋ํธ๋ฅจ 143 mEq/L
์นผ๋ฅจ 4.1 mEq/L
์ผํ๋ฌผ 98 mEq/L
์คํ์ฐ์ผ 22 mEq/L
ํ์ก ์์ ์ง์ 26 mg/dL
ํฌ๋ ์ํฐ๋ 2.3 mg/dL
ํฌ๋๋น 120 mg/dL
๋ค์ ์ฝ๋ฌผ ์ค ์ด๋ค ์ฝ๋ฌผ์ด ์ด ํ์์ ์คํ์ค ์ด์์ ์ ๋ฐํฉ๋๊น? | Lisinopril | {
"A": "๋๊ณก์ ",
"B": "ํํ ํ๋ผ์กธ",
"C": "๋ฆฌ์๋
ธํ๋ฆด",
"D": "๋ํธ๋ก๊ธ๋ฆฌ์ธ๋ฆฐ"
} | step1 | C | [
"year old man presents",
"emergency department",
"chest pain radiating to",
"left jaw",
"arm",
"states",
"similar symptoms",
"playing basketball",
"medical history",
"significant",
"diabetes mellitus",
"hypertension",
"GERD",
"takes metformin",
"hydrochlorothiazide",
"pantoprazole",
"blood pressure",
"90 mm Hg",
"pulse",
"100 min",
"respirations",
"min",
"ECG reveals ST elevation",
"leads V3 V6",
"hospitalized",
"acute MI",
"started on treatment",
"next day",
"dizziness",
"blurred vision",
"Repeat vital signs",
"follows",
"blood pressure 90 60 mm Hg",
"pulse 72 min",
"respirations",
"min",
"laboratory results",
"follows",
"Serum",
"mEq/L Potassium",
"98",
"Creatinine",
"Glucose",
"following drugs",
"responsible",
"patients lab abnormalities"
] | 00000000000000000052 |
28์ธ ์ฌ์ฑ์ด ๋จ์์น๊ตฌ์ ์ํด ๋ณ์์ผ๋ก ์ด์ก๋์์ต๋๋ค. ๊ทธ๋
๋ 3์ผ๊ฐ์ ๋ฐ์ด๊ณผ ๋ํต์ ๊ฒช์๊ณ , ์ดํ ํ๋ฃจ ๋์ ํผ๋๊ณผ ํ๊ฐ์ด ์
ํ๋์์ต๋๋ค. ๋ํ ๋ฌผ์ ์ ๊ณต๋ฐ์ ๋ ๊ฒฉ๋ ฌํ ๋ฐ์์ ๋ณด์
๋๋ค. ๊ทธ๋
์ ์ฒด์จ์ 101ยฐF (38.3ยฐC)์
๋๋ค. ๋ด์ํ๊ธฐ ๋ ๋ฌ ์ , ์ด ์ปคํ์ ์บ ํ์ ํ๋ ์ค ์ค๋๋ง์์ ๋ฐ์ฅ์ ๋ง์ฃผ์ณค์ต๋๋ค. ๋
ธ์ถ ์งํ ์ฃผ์ฌ ์ธ์, ์ด ํ์์๊ฒ ๊ฐ์ฅ ํจ๊ณผ์ ์ธ ์น๋ฃ๋ฒ์ ๋ฌด์์ด์์๊น์? | A killed vaccine within ten days of exposure | {
"A": "๋
ธ์ถ ํ 10์ผ ์ด๋ด์ ์ฌ๋ฐฑ์ (A killed vaccine within ten days of exposure)",
"B": "๋
ธ์ถ ํ 1์ฃผ์ผ ์ด๋ด์ Oseltamivir (Oseltamivir within one week of exposure)",
"C": "๋
ธ์ถ ํ ์ ์๊ฐ ์ด๋ด์ ๋
์ก ํญํ์ฒญ (Venom antiserum within hours of exposure)",
"D": "๋
ธ์ถ ํ ํ ๋ฌ ๋์์ Doxycycline (Doxycycline for one month after exposure)"
} | step1 | A | [
"year old woman",
"brought",
"hospital",
"boyfriend",
"three days",
"fever",
"headache followed by one day",
"worsening confusion",
"hallucinations",
"agitated",
"offered water",
"temperature",
"3C",
"Two months prior to presentation",
"couple",
"camping",
"encountered bats",
"injection",
"exposure",
"most effective",
"patient"
] | 00000000000000000053 |
60์ธ ๋จ์ฑ์ด ์์ ๋ cholecystectomy ์ ์ ์ง์ฐฐ์ ๋ฐ๊ธฐ ์ํด ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ๊ทธ๋ hydrochlorothiazide๋ก ์น๋ฃ๋ฐ๋ hypertension์ ์๊ณ ์์ต๋๋ค. ๊ทธ์ ์ด๋จธ๋๋ ๋ง์ฑ ํ ์ก์์ข
์งํ์ ์์์ต๋๋ค. ๊ทธ๋ ์ ๋ฆฌ ์ ์กฐ ๊ณต์ฅ์์ ์ผํฉ๋๋ค. ๊ทธ๋ 38๋
๋์ ๋งค์ผ ๋ ๊ฐ์ ๋ด๋ฐฐ๋ฅผ ํผ์ ์ต๋๋ค. ๊ทธ์ ํ๋ ฅ ์งํ๋ ์ ์ ๋ฒ์ ๋ด์ ์์ต๋๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ ์ด์ ์๊ฒฌ์ ์์ต๋๋ค. ์คํ์ค ์ฐ๊ตฌ๋ ์ฐธ์กฐ ๋ฒ์ ๋ด์ ์์ต๋๋ค. ํ๋ถ ์์ค๋ ์ด ์ฌ์ง์ด ์ ์๋์์ต๋๋ค. ๋ค์ ์ค ๊ด๋ฆฌ์์ ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Request previous chest x-ray | {
"A": "Perform arterial blood gas analysis",
"B": "Perform CT-guided biopsy",
"C": "Measure angiotensin-converting enzyme",
"D": "Request previous chest x-ray"
} | step2&3 | D | [
"60 year old man",
"physician",
"examination prior to",
"scheduled cholecystectomy",
"hypertension treated with hydrochlorothiazide",
"mother",
"chronic granulomatous disease of the lung",
"works",
"glass manufacturing plant",
"smoked two packs",
"cigarettes daily",
"years",
"vital signs",
"normal limits",
"Examination shows",
"abnormalities",
"Laboratory studies",
"reference range",
"x-ray of",
"chest",
"shown",
"following",
"most appropriate next step",
"management"
] | 00000000000000000054 |
3์ผ ๋ ์ ์์๋ฅผ ๊ฒ์ฌํ๊ณ ์์ผ๋ฉฐ, ๋ถ๋ง ๊ณผ์ ์์ ์๋ฌด๋ฐ ํฉ๋ณ์ฆ ์์ด ์ง์ ๋ถ๋ง๋์์ต๋๋ค. ์ ์์๋ ๊ตฌํ , ๊ณผํธํก, ๊ธฐ๋ฉด, ๋ฐ์์ ๋ณด์
๋๋ค. ํ์ก ๊ฒ์ฌ ๊ฒฐ๊ณผ ๊ณ ์๋ชจ๋์ํ์ฆ, ๊ธ๋ฃจํ๋ฏผ ์์น ์์น, ํ์ค ์์ ์ง์ ๊ฐ์๊ฐ ๋ํ๋ฌ์ต๋๋ค. CT ์ค์บ ๊ฒฐ๊ณผ ๋๋ถ์ข
์ด ๋ํ๋ฌ์ต๋๋ค. ๋ค์ ํจ์ ์ค ์ด๋ค ํจ์์ ๊ฒฐํจ์ด ์ด ์์์ ์ ์ฌํ ์์ ์ฆ์์ ์ ๋ฐํ ์ ์์ต๋๊น? | Carbamoyl phosphate synthetase I | {
"A": "Phenylalanine hydroxylase",
"B": "Branched-chain ketoacid dehydrogenase",
"C": "Cystathionine synthase",
"D": "Carbamoyl phosphate synthetase I"
} | step1 | D | [
"examining",
"3 day old newborn",
"delivered",
"complications",
"newborn presents",
"vomiting",
"hyperventilation",
"lethargy",
"seizures",
"Blood work demonstrates hyperammonemia",
"elevated glutamine levels",
"decreased blood urea nitrogen",
"CT scan demonstrates cerebral edema",
"Defects",
"following enzymes",
"result",
"clinical presentation similar",
"infant"
] | 00000000000000000055 |
HIV๋ฅผ ๊ฐ์ง 48์ธ ๋จ์ฑ์ด 2์ฃผ ๋์ ์ผ๊ตด๊ณผ ๋ชฉ์ ํผ๋ถ ๋ณ๋ณ์ด ์๊ฒจ ์์ฌ์๊ฒ ์๋ค. ๊ฐ๋ ต๊ฑฐ๋ ์ํ์ง๋ ์๋ค. ์ด์ด๋ ์ธํํต์ ์๋ค. 3๊ฐ์ ์ ์ ์นธ๋๋ค์ฑ ์๋์ผ ์น๋ฃ๋ฅผ ๋ฐ์๋ค. ๊ทธ๋ ์๋ด์ ์ฑ์ ์ผ๋ก ํ๋์ ์ด๋ฉฐ ์๋ด๋ ๊ทธ์ ์ํ๋ฅผ ์๊ณ ์์ผ๋ฉฐ ์ฝ๋์ ๊พธ์คํ ์ฌ์ฉํ๋ค. ํ์ฌ lamivudine, abacavir, efavirenz๋ก ์ผ์ค ํญ๋ ํธ๋ก๋ฐ์ด๋ฌ์ค ์๋ฒ์ ๋ฐ๊ณ ์๋ค. ๊ทธ๋ ํค 175 cm (5 ft 9 in)์ด๊ณ ์ฒด์ค์ 58 kg (128 lb)์ด๋ฉฐ BMI๋ 18.8 kg/m2์ด๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ ์ผ๊ตด๊ณผ ๋ชฉ์ ์ํน ๋ค์ด๊ฐ ์ค์ฌ์ด ์๋ ์ฌ๋ฌ ๊ฐ์ ํผ๋ถ์ ๊ตฌ์ง์ด ๋ํ๋๋ค. ๊ฒฝ๋ถ ๋ฆผํ์ ๋ณ์ฆ์ด ์๋ค. ๋๋จธ์ง ๊ฒ์ฌ๋ ํน์ด ์ฌํญ์ด ์๋ค. ํค๋ชจ๊ธ๋ก๋น ๋๋๋ 12.1 g/dL, ๋ฐฑํ๊ตฌ ์๋ 4,900/mm3, ํ์ํ ์๋ 143,000/mm3์ด๋ค. ํ์ฒญ ๊ฒ์ฌ์ ์๋ณ ๊ฒ์ฌ์์๋ ์ด์์ด ์๋ค. CD4+ T-lymphocyte ์๋ 312/mm3 (์ ์ โฅ 500)์ด๋ค. ๋ค์ ์ค ์ด ํ์์ ์๊ฒฌ์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์์ธ์ ๋ฌด์์ธ๊ฐ? | Poxvirus | {
"A": "Bartonella",
"B": "Papillomavirus",
"C": "Poxvirus",
"D": "Coccidioides"
} | step2&3 | C | [
"48 year old man",
"HIV",
"physician",
"of skin lesions",
"face",
"neck",
"2 weeks",
"not itchy",
"painful",
"not",
"fever",
"sore throat",
"treated",
"candidal esophagitis",
"months",
"sexually active",
"wife",
"condition",
"uses condoms",
"currently receiving triple antiretroviral therapy",
"lamivudine",
"abacavir",
"efavirenz",
"5 ft 9",
"tall",
"58 kg",
"BMI",
"kg/m2",
"Examination shows multiple skin colored papules",
"face",
"neck",
"dimpled center",
"lymphadenopathy",
"present",
"examination",
"unremarkable",
"hemoglobin concentration",
"g/dL",
"leukocyte count",
"4 900 mm3",
"platelet count",
"mm3",
"serum studies",
"urinalysis show",
"abnormalities",
"CD4",
"T-lymphocyte",
"312 mm3",
"normal",
"500",
"following",
"most likely cause",
"patient's findings"
] | 00000000000000000056 |
55์ธ ๋จ์ฑ์ด 4์ฃผ ๋์์ ํผ๋ก๊ฐ๊ณผ ์
ํ๋๋ ๋ณตํต์ผ๋ก ์ธํด ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ๊ทธ๋ ๋ํ ๊ณผ๋ํ ์ผ๊ฐ ๋ฐํ๊ณผ ์ด ๊ธฐ๊ฐ ๋์ 5.4kg(12lb)์ ์ฒด์ค ๊ฐ์๋ฅผ ๋ณด๊ณ ํฉ๋๋ค. ๊ทธ๋ 4์ผ ๋์ ๋ชฉ์ด ๋ถ์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ์ํต์ด ์๊ณ , ๋น๋ํด์ก์ผ๋ฉฐ, ๊ณ ์ ๋ ์๊ณจ์ ๋ฆผํ์ ์ด ๋ํ๋ฉ๋๋ค. ๋น์ฅ๋น๋๊ฐ ์์ต๋๋ค. ํ๋ถ ๋ฐ ๋ณต๋ถ์ CT ์ค์บ ๊ฒฐ๊ณผ ์ก์, ์ข
๊ฒฉ๋ ๋ฐ ๊ฒฝ๋ถ ๋ฆผํ์ ์ด ๊ด๋ฒ์ํ๊ฒ ๋น๋ํด์ง ๊ฒ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ์ ์ ๋ ๊ฒฝ๋ถ ๋ฆผํ์ ๋ถ์ ๊ฒฐ๊ณผ CD20์ ๋ํด ์์ฑ์ผ๋ก ์ผ์๋๋ ๋์ ์ฆ์ ์ง์๋ฅผ ๊ฐ์ง ๋ฆผํ๊ตฌ๊ฐ ๋ํ๋ฌ์ต๋๋ค. ๋ค์ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Diffuse large B-cell lymphoma | {
"A": "Adult T-cell lymphoma",
"B": "Burkitt lymphoma",
"C": "Diffuse large B-cell lymphoma",
"D": "Hodgkin lymphoma"
} | step1 | C | [
"55 year old man",
"physician",
"fatigue",
"worsening abdominal",
"weeks",
"reports excessive night sweats",
"5.4 kg",
"weight loss",
"time",
"neck swelling",
"4 days",
"Physical examination shows",
"nontender",
"enlarged",
"fixed supraclavicular",
"splenomegaly",
"CT scan",
"thorax",
"abdomen shows massively enlarged axillary",
"mediastinal",
"cervical lymph nodes",
"Analysis",
"shows lymphocytes",
"high proliferative index",
"stain positive",
"CD20",
"following",
"most likely diagnosis"
] | 00000000000000000057 |
32์ฃผ ์์ ์ค์ธ 26์ธ์ G1P0 ์ฌ์ฑ์ด ์ถ์ ์ด์ํ ๊ฒ์ฌ๋ฅผ ์ํด ๋ด์ํ์ต๋๋ค. ๊ทธ๋
๋ ์์ 2๊ธฐ ๋์ gestational diabetes ์ง๋จ์ ๋ฐ์์ง๋ง, ํ๋น ์กฐ์ ๋ถ๋๊ณผ ์ธ์๋ฆฐ ์น๋ฃ ๋น์์์ ์ธ์ ํ์ต๋๋ค. ํ์ ์ด์ํ ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋น๋์นญ์ ์ธ ํ์ฅ๋ interventricular septum, ์ข์ฌ์ค ์ ์ถ๋ก ํ์ ๋ฐ ํ์ ํ ๊ฐ์๋ ejection fraction์ด ๊ด์ฐฐ๋์์ต๋๋ค. ๋ค์ ์ค ๋ถ๋ง ํ ๊ด๋ฆฌ์์ ๊ฐ์ฅ ์ ์ ํ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Medical management | {
"A": "Emergent open fetal surgery",
"B": "Cardiac magnetic resonance imaging",
"C": "Cardiac catheterization",
"D": "Medical management"
} | step2&3 | D | [
"year old",
"woman",
"weeks presents",
"follow-up ultrasound",
"diagnosed",
"gestational diabetes",
"second trimester",
"admits",
"poor glucose control",
"non",
"insulin therapy",
"Fetal reveals",
"asymmetric",
"enlarged interventricular septum",
"left ventricular outflow tract obstruction",
"reduced ejection fraction",
"following",
"most appropriate step",
"management",
"delivery"
] | 00000000000000000058 |
์ต๊ทผ ์ฐ๊ตฌ์์๋ "patient satisfaction" ์ค์ฌ์ ์๋ฃ ์๋น์ค ์ฆ๊ฐ๊ฐ ์
์ ์ฆ๊ฐ๋ก ์ด์ด์ง๋์ง ๋ถ์ํ๊ณ ์ ํ์ต๋๋ค. ์ด ๋ณ์์์ ์ผ๋ถ ๋ณ๋์ "patient satisfaction" ์ค์ฌ ์๋ฃ ์๋น์ค์ ์๋ก์ด ์ธก๋ฉด์ ๋์
ํ ๋ฐ๋ฉด, ๋๋จธ์ง ๋ณ์์ ๊ธฐ์กด ํ๋กํ ์ฝ์ ๊ณ์ ์ฌ์ฉํ์ต๋๋ค. ์ฐ๊ตฌ ์์ ์์ ์ ๊ธฐ์ค ๋ชจ์ง๋จ ํน์ฑ ๋ฐ ์ธ๊ตฌ ํต๊ณ๊ฐ ์์ง๋์์ต๋๋ค. ๋ค์ ํด ๋ง์ ๋ณ์ ์ด์ฉ๋ฅ ์ ํ๊ฐํ๊ณ ๋ ๊ทธ๋ฃน ๊ฐ์ ๋น๊ตํ์ต๋๋ค. ๋ค์ ์ค ์ด ์ ํ์ ์ฐ๊ตฌ๋ฅผ ๊ฐ์ฅ ์ ์ค๋ช
ํ๋ ๊ฒ์ ๋ฌด์์
๋๊น? | Prospective cohort | {
"A": "Prospective cohort",
"B": "Retrospective case-control",
"C": "Prospective case-control",
"D": "Cross-sectional study"
} | step1 | A | [
"recent study attempted to",
"increased",
"patient satisfaction",
"driven healthcare resulted",
"increased hospitalization",
"hospital",
"several",
"wards adopted new aspects",
"patient satisfaction",
"driven healthcare",
"hospital continued to use",
"protocols",
"Baseline population",
"demographics",
"collected",
"start",
"study",
"end",
"following year",
"hospital use",
"assessed",
"compared",
"two groups",
"following best",
"type",
"study"
] | 00000000000000000059 |
๋น๋จ๋ง๋ง๋ณ์ฆ ์ง๋จ์ ์ํ ์๊ฒฉ ์๋ฃ ์ ๊ทผ๋ฒ์ ํ์ฉํ๋ ์๋ก์ด ์ ๋ณ ๊ฒ์ฌ๊ฐ ๋น๋จ๋ณ ํด๋ฆฌ๋์์ ์ํ๋์์ต๋๋ค. ์๊ณผ ์ ๋ฌธ์์ ๊ฒ์ฌ ๋ํ ๋ชจ๋ ํ์์๊ฒ ์ง๋จ์ gold standard๋ก์ ์ํ๋์์ต๋๋ค. 500๋ช
์ ํ์๋ฅผ ๋์์ผ๋ก ํ ์๋น ์ฐ๊ตฌ์์, ์ ๋ณ ๊ฒ์ฌ๋ 250๋ช
์ ํ์์๊ฒ์ ๋น๋จ๋ง๋ง๋ณ์ฆ์ ์กด์ฌ๋ฅผ ๊ฐ์งํ์ต๋๋ค. ์๊ณผ ์ ๋ฌธ์ ๊ฒ์ฌ๋ ์ ๋ณ ๊ฒ์ฌ์์ ์์ฑ ๋ฐ์์ ๋ณด์ธ 200๋ช
์ ํ์๋ฟ๋ง ์๋๋ผ ์ ๋ณ ๊ฒ์ฌ์์ ์์ฑ ๋ฐ์์ ๋ณด์ธ 10๋ช
์ ํ์์๊ฒ์ ๋น๋จ๋ง๋ง๋ณ์ฆ ์ง๋จ์ ํ์ธํ์ต๋๋ค. ์ ๋ณ ๊ฒ์ฌ์ ๋ฏผ๊ฐ๋, ํน์ด๋, ์์ฑ ์์ธก๋ ๋ฐ ์์ฑ ์์ธก๋๋ ๋ฌด์์
๋๊น? | Sensitivity = 95%, Specificity = 83%, PPV = 80%, NPV = 96% | {
"A": "Sensitivity = 83%, Specificity = 95%, PPV = 80%, NPV = 96%",
"B": "Sensitivity = 83%, Specificity = 95%, PPV = 96%, NPV = 80%",
"C": "Sensitivity = 80%, Specificity = 95%, PPV = 96%, NPV = 83%",
"D": "Sensitivity = 95%, Specificity = 83%, PPV = 80%, NPV = 96%"
} | step2&3 | D | [
"new screening test",
"telemedicine approach",
"diagnosing diabetic retinopathy",
"implemented",
"diabetes clinic",
"ophthalmologists exam",
"performed",
"patients",
"gold",
"diagnosis",
"pilot study",
"500 patients",
"screening test detected",
"presence",
"diabetic retinopathy",
"patients",
"Ophthalmologist exam confirmed",
"diagnosis",
"diabetic retinopathy",
"200 patients",
"tested positive",
"screening test",
"10 patients",
"tested negative",
"screening test",
"sensitivity",
"specificity",
"positive predictive value",
"negative predictive value of",
"screening test"
] | 00000000000000000060 |
๊ฑด๊ฐํ 22์ธ ๋จ์ฑ์ด ๊ณจ๊ฒฉ๊ทผ๊ณผ ์ฌ์ฅ ๊ทผ์ก์ ํน์ฑ์ ๋น๊ตํ๊ธฐ ์ํด ๊ทํ๊ฐ ์ฃผ๋ํ๋ ์ฐ๊ตฌ์ ์ฐธ์ฌํฉ๋๋ค. ๊ทํ๋ ํด๋น ์ฐธ๊ฐ์์ ํจ๊ป 3๋จ๊ณ ์คํ์ ์ํํฉ๋๋ค. ์ฒซ ๋ฒ์งธ ๋จ๊ณ์์๋ ์ฐธ๊ฐ์์๊ฒ ์ผ์์ผ๋ก 2.3kg (5 lb) ๋ฌด๊ฒ๋ฅผ ํ
์ด๋ธ์์ ๋ค์ด ์ฌ๋ฆฌ๋๋ก ํฉ๋๋ค. ๋ ๋ฒ์งธ ๋จ๊ณ์์๋ 20ํ์ ๋ฒํผ ํ
์คํธ๋ฅผ ์ํํ๊ฒ ํ์ฌ ์ฌ๋ฐ์๋ฅผ ๋ถ๋น 150ํ๋ก ์ฆ๊ฐ์ํต๋๋ค. ์ธ ๋ฒ์งธ ๋จ๊ณ์์๋ ์ฐธ๊ฐ์์ ๋น๋ณต๊ทผ์ 50Hz ์ฃผํ์๋ก ์ ๊ธฐ ์๊ทน์ ๊ฐํฉ๋๋ค. ๊ทํ๋ ๋ค์๊ณผ ๊ฐ์ด ํน์ ๊ทผ์ก์ ์ฅ๋ ฅ๊ณผ ์ ๊ธฐ์ ํ๋์ ๊ด์ฌ์ด ์์ต๋๋ค: 1๋จ๊ณ์ ์ด๋๊ทผ, 2๋จ๊ณ์ ์ฌ์ฅ ๊ทผ์ก, 3๋จ๊ณ์ ๋น๋ณต๊ทผ. ๊ฐ ๋จ๊ณ์ ๊ด๋ จ๋ ๊ทผ์ก์์ ์ด๋ค ์ผ์ด ์ผ์ด๋ ๊ฒ์ผ๋ก ์์ํ์ญ๋๊น? | Increase of tension in all phases | {
"A": "์คํ 1๊ณผ 2 ์์ ์ ์์ด๋ ๋จ์ ๋์",
"B": "์คํ 1์์ ๋์ด๋ ๋จ์ ๋์ ํ ์์ด๋ ๋จ์ ๋์",
"C": "์ธ ์คํ ๋ชจ๋ ์ข
๋ฃ ์ ์ตํฉ๋ ๊ฐ์ถ ์์ถ",
"D": "๋ชจ๋ ๋จ๊ณ์์ ์ฅ๋ ฅ ์ฆ๊ฐ"
} | step1 | D | [
"healthy",
"year old male",
"research study",
"leading to compare",
"properties",
"skeletal",
"cardiac muscle",
"conduct",
"3-phased experiment",
"participant",
"first phase",
"to lift",
"kg",
"5",
"weight",
"table",
"left hand",
"second phase",
"to",
"20",
"taking",
"heart rate",
"min",
"third phase",
"electrically",
"gastrocnemius",
"frequency",
"50 Hz",
"interested",
"tension",
"electrical",
"specific muscles",
"follows",
"Biceps",
"phase 1",
"cardiac muscle",
"phase 2",
"gastrocnemius",
"phase 3",
"to",
"phases",
"muscles",
"interest"
] | 00000000000000000061 |
20์ธ ๋จ์ฑ์ด ๋๊ตฌ ๊ฒฝ๊ธฐ ์ค ๋์ด์ง ํ ์ดํ ๋ค ๊ทํ์ ์ฌ๋ฌด์ค๋ก ๋ด์ํ์ต๋๋ค. ํ์๋ ๋ฌด๋ฆ ์ธ์ธก ๋ถ์๊ฐ ๋ค๋ฅธ ์ ์์ ๋ฌด๋ฆ๊ณผ ์ถฉ๋ํ๋ค๊ณ ์ง์ ํฉ๋๋ค. ์ง์ฐฐ ๊ฒฐ๊ณผ, ํ์์ ์ค๋ฅธ์ชฝ ๋ฌด๋ฆ์ ๋ถ๊ธฐ๋ ์ผ์ถ ์์ด ์ผ์ชฝ ๋ฌด๋ฆ๊ณผ ๊ฐ์ ํฌ๊ธฐ๋ก ๋ณด์
๋๋ค. ํ์๋ ์์ชฝ ๋ค๋ฆฌ์ ๊ฐ๊ฐ๊ณผ ๊ทผ๋ ฅ์ด ์จ์ ํฉ๋๋ค. ํ์์ ์ค๋ฅธ์ชฝ ๋ฌด๋ฆ์ ๋ด๋ฐ ์คํธ๋ ์ค ๊ฒ์ฌ ์ ์ด์์ด ์์ง๋ง, ์ธ๋ฐ ์คํธ๋ ์ค ๊ฒ์ฌ ์ ์ผ์ชฝ ๋ฌด๋ฆ๊ณผ ๋น๊ตํ์ฌ ๋ ์ด์๋ฉ๋๋ค. Lachman's test์ posterior drawer test ๋ชจ๋ ์ด์ ์์ด ๋จ๋จํ ์ข
์ ์ ๋ณด์
๋๋ค. ๋ค์ ์ค ํ์๊ฐ ์์๋ ๊ตฌ์กฐ๋ฌผ์ ๋ฌด์์
๋๊น? | Medial collateral ligament | {
"A": "Posterior cruciate ligament",
"B": "Anterior cruciate ligament",
"C": "Medial collateral ligament",
"D": "Lateral collateral ligament"
} | step2&3 | C | [
"20 year old male",
"office two days",
"falling",
"pick",
"basketball game",
"patient states",
"lateral aspect of",
"knee",
"knee",
"exam",
"patient's appears",
"same size",
"left knee",
"swelling",
"effusion",
"patient",
"intact sensation",
"strength",
"lower extremities",
"patient's",
"laxity",
"varus stress test",
"more lax",
"valgus stress test",
"compared",
"left knee",
"Lachman's test",
"posterior drawer test",
"firm endpoints",
"laxity",
"following structures",
"patient injured"
] | 00000000000000000062 |
4์ธ ๋จ์ ์์ด๊ฐ 4์ผ ๋์ ๋ ์ฃผ์ ๋ถ์ข
์ผ๋ก ์ธํด ์์ฌ์๊ฒ ์ง์ฐฐ์ ๋ฐ์ผ๋ฌ ์๋ค. ๋ถ์ข
์ ์์นจ์ ๊ฐ์ฅ ์ฌํ๊ณ ์ทจ์นจ ์๊ฐ์๋ ๋ ์ํ๋๋ค. 10์ผ ์ , ๊ทธ๋ ์ ์ ๋ก ๋์์ง ์ธํํต์ ์์๋ค. ๊ทธ์ ์ฒด์จ์ 37ยฐC (98.6ยฐF), ๋งฅ๋ฐ์ 103/min, ํ์์ 88/52 mm Hg์ด๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ, ํ์ง์ 3+ ํจ์ ๋ถ์ข
๊ณผ ๋ ์ฃผ์ ๋ถ์ข
์ด ๋ํ๋ฌ๋ค. ๋๋จธ์ง ๊ฒ์ฌ์์๋ ์ด์์ด ๋ฐ๊ฒฌ๋์ง ์์๋ค. ์คํ์ค ์ฐ๊ตฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ๋ค.
Hemoglobin 15.3 g/dL
Leukocyte count 10,500/mm3
Platelet count 480,000/mm3
Serum
Urea nitrogen 36 mg/dL
Glucose 67 mg/dL
Creatinine 0.8 mg/dL
Albumin 2.6 mg/dL
Urine
Blood negative
Glucose negative
Protein 4+
RBC none
WBC 0-1/hpf
Fatty casts numerous
Protein/creatinine ratio 6.8 (N โค0.2)
Serum complement ๋๋๋ ์ฐธ๊ณ ๋ฒ์ ๋ด์ ์๋ค. ๋ค์ ์ค ๊ด๋ฆฌ์์ ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ๋ ๋ฌด์์ธ๊ฐ? | Prednisone therapy | {
"A": "Enalapril therapy",
"B": "Furosemide therapy",
"C": "Anti-streptolysin O levels",
"D": "Prednisone therapy"
} | step2&3 | D | [
"4 year old boy",
"brought",
"physician",
"of swelling",
"eyes",
"4 days",
"swelling",
"most severe",
"morning",
"milder",
"bedtime",
"Ten days",
"sore throat",
"resolved",
"temperature",
"98",
"pulse",
"min",
"blood pressure",
"88",
"mm Hg",
"Examination shows 3",
"pitting edema of",
"lower extremities",
"periorbital edema",
"examination shows",
"abnormalities",
"Laboratory studies show",
"g",
"mm3 Platelet count",
"mg",
"mg",
"Creatinine",
"8",
"Urine",
"negative",
"RBC",
"WBC",
"hpf",
"casts numerous Protein/creatinine ratio",
"N 0.2",
"Serum complement concentrations",
"reference ranges",
"following",
"most appropriate next step",
"management"
] | 00000000000000000063 |
18์ธ ๋จ์๊ฐ ์์ชฝ ํ์ "๋ฐ๋๊ฑฐ๋ฆผ" ์ฆ์์ผ๋ก ์ด๋จธ๋์ ํจ๊ป ์ง๋ฃ์ค์ ๋ฐฉ๋ฌธํ์ต๋๋ค. ๊ทธ๋ 1์ฃผ์ผ ์ ์ ์์ ๋ฐ์ ์ต๊ทผ์ ์ ๋ฐฉ ์ญ์ ์ธ๋(ACL) ํ์ด ์ธ์๋ ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ ๋ถ์ธํฉ๋๋ค. ํ์๋ ์ด์ ๊ฐ๊ฐ์ด ์ฃผ๋ก ์ผ์ชฝ ํ์ ํ๋ฉด ์ ์๋ถ์ ๋ ๋ง์ด ๋ํ๋๋ค๊ณ ๋ณด๊ณ ํฉ๋๋ค. ์ด ํ์์๊ฒ์ ์ด๋ค ์ ์ฒด ๊ฒ์ฌ ์๊ฒฌ์ ์์ํ ์ ์์ต๋๊น? | Loss of wrist extension | {
"A": "ํ ๋ฒ๋ฆผ ์์ค",
"B": "์๊ฐ๋ฝ ๋ฒ๋ฆผ ์์ค",
"C": "์ ์ ๊ตด๊ณก ๋ฐ ํ์ธ ์์ค",
"D": "์๋ชฉ ์ ์ ์์ค"
} | step1 | D | [
"year old man",
"clinic",
"mom",
"pins",
"needles",
"arms",
"denies",
"past medical history",
"recent anterior cruciate ligament",
"tear",
"repaired 1 week",
"patient reports",
"paresthesias",
"mostly",
"posterior forearms",
"left more",
"right",
"physical examination finding",
"patient"
] | 00000000000000000064 |
9์ธ ์ฌ์์์ด๊ฐ ์ฌ๋ฐ์ฑ ๋ฐ์์ ๋ํ ์ ๋งฅ ์ฃผ์ฌ์ฉ ํ๋ํ ์ธ(phenytoin)์ ์ค๋ฅ ์ฉ๋ ํฌ์ฌ ํ ์์๋์์ต๋๋ค. ์ด ์ฌ๊ฑด์ ๋น๊ตญ์ ๋ณด๊ณ ๋ฉ๋๋ค. ์ฒ ์ ํ ์กฐ์ฌ๋ฅผ ํตํด ์ฌ๊ฑด์ ์ ๋ฐํ ๋ค์ํ ์์ธ ์์ธ์ด ๋ฐํ์ก์ต๋๋ค. ํ ๊ฐ์ง ์ค์ํ ๋ฐ๊ฒฌ์ ํ์ ์ธ์์ธ๊ณ ๊ณผ์ ์์ ์ฒ๋ฐฉ์ ๋ด๋ฆฐ ์์ ๋ ์ง๋ํธ์ ํฌ์ฝ์ ๋ด๋นํ 1๋
์ฐจ ๋ ์ง๋ํธ ๊ฐ์ ํ๋ํ ์ธ ์ฉ๋์ ๋ํ ๊ตฌ๋ ์คํด๊ฐ ์์๋ค๋ ๊ฒ์
๋๋ค. ํฅํ ์ด ํน์ ์ค๋ฅ์ ์ํ์ ์ต์ํํ๊ธฐ ์ํด ๊ฐ์ฅ ์ ์ ํ ๊ด๋ฆฌ๋ ๋ค์ ์ค ๋ฌด์์ ์ํํ๋ ๊ฒ์
๋๊น? | Closed-loop communication | {
"A": "ํ์ ๋ฃจํ ์์ฌ์ํต",
"B": "์์ฐจ ์ฌ๊ณ ",
"C": "๊ทผ๋ณธ ์์ธ ๋ถ์",
"D": "์ค๋ํ ์ฌ๊ฑด"
} | step2&3 | A | [
"year old girl",
"resuscitated",
"administration",
"erroneous dose",
"intravenous phenytoin",
"recurrent seizures",
"incident",
"reported",
"authorities",
"investigation reveals various",
"factors leading",
"event",
"One important finding",
"verbal",
"dose",
"phenytoin",
"ordering senior resident",
"receiving first year resident",
"handover",
"patient",
"To",
"risk",
"error",
"future",
"most appropriate management",
"to",
"following"
] | 00000000000000000065 |
๊ทํ๋ NBA ๋๊ตฌํ์ ํ ์ฃผ์น์์
๋๋ค. ์ค์ํ ํ๋ ์ด์คํ ๊ฒฝ๊ธฐ ๋น์ผ ์์นจ, ์คํ ์ ์์ธ P ์จ์ EKG์์ ๋น๋์ฑ ์ฌ๊ทผ์ฆ(HCM)์ด ์์ฌ๋๋ ์๊ฒฌ์ด ๋ํ๋ฌ์ต๋๋ค. P ์จ๋ ๊ฑด๊ฐํ๊ณ , ์ ์ฒด์ ์ผ๋ก ์ ํฉํ, ์ง์
์ ์ธ ์ด๋์ ์์
๋๋ค.
๊ทธ๋ ๋ฐค ํ๋ ์ด์คํ ๊ฒฝ๊ธฐ๋ P ์จ์ ๊ฒฝ๋ ฅ์์ ๊ฐ์ฅ ์ค์ํ ๊ฒฝ๊ธฐ์
๋๋ค. P ์จ์ ์ถ์ ์ ์ ํํ ๊ฒ์ ๊ณ ๋ คํ๊ณ ์๋ค๊ณ ์ฝ์น์๊ฒ ์๋ฆฌ์, ๊ทธ๋ ๊ทํ๋ฅผ ํด๊ณ ํ๊ฒ ๋ค๊ณ ์ํํฉ๋๋ค. ๊ทธ๋ ๋ฆ๊ฒ, ํ ๊ตฌ๋จ์ฃผ๋ก๋ถํฐ P ์จ์ ๊ฒฝ๊ธฐ๋ฅผ ์ ํํ ๊ฒฝ์ฐ ์์ก์ ์ ๊ธฐํ๊ฒ ๋ค๋ ์ ํ๊ฐ ๊ฑธ๋ ค์ต๋๋ค. P ์จ๋ "์ฃฝ๊ธฐ ์ด๊ธฐ๋ก๋ผ๋" ๊ฒฝ๊ธฐ์ ์ถ์ ํ๊ฒ ๋ค๊ณ ๋งํฉ๋๋ค.
๋ค์ ์ค ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Educate Mr. P about the risks of HCM | {
"A": "์ ์ ๊ณผ ์์ฌ์ ์๋ดํ์ฌ P ์จ๋ฅผ ์
์์ํจ๋ค",
"B": "๊ฒฝ์ฐฐ์ ์ ๊ณ ํ์ฌ P ์จ๋ฅผ ์ฒดํฌํ๋ค",
"C": "์ํ์ ๊ถ๊ณ ์ ๋ฐํ์ฌ P ์จ๊ฐ ๊ฒฝ๊ธฐ์ ์ถ์ ํ๋๋ก ํ๋ฝํ๋ค",
"D": "P ์จ์๊ฒ HCM์ ์ํ์ฑ์ ๋ํด ๊ต์กํ๋ค"
} | step1 | D | [
"team physician",
"NBA basketball",
"morning",
"important",
"game",
"EKG",
"star",
"Mr",
"shows findings suspicious",
"hypertrophic cardiomyopathy",
"Mr",
"healthy",
"fit",
"professional athlete",
"game",
"night",
"the most important",
"Mr",
"P",
"areer.",
"nform ",
"oach ",
"hinking ",
"estricting r.",
"'",
"rticipation, ",
" f re y",
"ter t",
"y y",
"ceive a",
"one call f",
"ner o",
"am t",
"strict M . ",
"s",
"lity to pl y. M",
" P",
"t tes th",
"ying in",
"e \"i",
" thi g I d .",
"owing is ",
" app opriate nex ste ?"
] | 00000000000000000066 |
37์ธ ์ฌ์ฑ ํ์๊ฐ ์ ์ ์ ์ธ ๊ถํ๊ฐ, ์ ์ฝ, ๋ํต, ๋ฉ์ค๊บผ์, ๊ตฌํ ๋ฐ ์ค์ฌ๋ฅผ ํธ์ํ๋ฉฐ ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ํ์๋ ๋๋ต ์ดํ ์ ์ ๊ฑด๊ฐํ๊ฒ ๋๊ผ๋ค๊ณ ํฉ๋๋ค. ํ์๋ ๊ทธ ์ธ ๊ฑด๊ฐํ๋ฉฐ, ๋ณต์ฉํ๋ ์ฝ๋ฌผ์ ์์ต๋๋ค. ํ๋ ฅ ์งํ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค: ์ฒด์จ 38.0, ์ฌ๋ฐ์ ๋ถ๋น 96ํ, ํ์ 110/73, ์ค๋ด ๊ณต๊ธฐ ์ค ์ฐ์ ํฌํ๋ 96%. ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋ค์ ์ํ ๋ณด์ด๋ ์ฌ์ฑ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ํ์๋ ์กธ๋ฆฌ์ง๋ง ๊ฐ์ฑ ๊ฐ๋ฅํ๋ฉฐ, ๊ตญ์์ ์ธ ์ ๊ฒฝํ์ ๊ฒฐ์์ ์์ต๋๋ค. ์ด๊ธฐ ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ํค๋งํ ํฌ๋ฆฟ 26%, ํ์ํ 80,000/mL, ํ์ฒญ ํฌ๋ ์ํฐ๋ 1.5 mg/dL๋ก ๋ํ๋ฌ์ต๋๋ค. ํ์ฌ ์์ ์์ ๋ค์ ์ค ๊ฐ์ฅ ์ ์ ํ ์น๋ฃ๋ฒ์ ๋ฌด์์
๋๊น? | Plasma exchange therapy | {
"A": "๊ณ ์ฉ๋ ๊ธ๋ฃจ์ฝ์ฝ๋ฅดํฐ์ฝ์ด๋",
"B": "์ฌ์ดํด๋กํฌ์คํ๋ฏธ๋ ๋ฐ ๋ฆฌํญ์๋ง",
"C": "๋ฐ์ฝ๋ง์ด์ ๋ฐ ์ธํํ",
"D": "ํ์ฅ ๊ตํ ์๋ฒ"
} | step2&3 | D | [
"year old woman presents",
"emergency department",
"generalized malaise",
"weakness",
"headache",
"nausea",
"vomiting",
"diarrhea",
"last felt well",
"two days",
"healthy",
"takes",
"medications",
"vital signs",
"T",
"0",
"96 beats per minute",
"BP",
"O2 sat 96",
"room air",
"Examination reveals",
"somewhat ill appearing woman",
"drowsy",
"focal neurological deficits",
"Initial laboratory studies",
"notable",
"hematocrit",
"platelets",
"80",
"mL",
"serum creatinine",
"mg dL",
"following",
"most appropriate treatment",
"time"
] | 00000000000000000067 |
36์ฃผ์ ํ์ด๋ ์ํ 5์ฃผ๋ ์์๊ฐ ๊ฑด๊ฐ ๊ฒ์ง์ ์ํด ์์ฌ๋ฅผ ์ฐพ์์ต๋๋ค. ์ด๋จธ๋๋ ์ด์ ์ 2์๊ฐ๋ง๋ค 15๋ถ ๋์ ๋ชจ์ ์์ ๋ฅผ ํ์ง๋ง ํ์ฌ๋ 4์๊ฐ๋ง๋ค 40๋ถ ๋์ ์์ ๋ฅผ ํ๋ค๊ณ ๋ณด๊ณ ํ์ต๋๋ค. ์์๋ ํ๋ฃจ์ ๊ธฐ์ ๊ท๋ฅผ 6๋ฒ ์ ์๊ณ ๋ ๋ฒ ๋ณ์ ๋ด
๋๋ค. ํ์ฌ ์ฒด์ค์ 3500g (7.7 lb)์ด๊ณ ์ ์ฅ์ 52cm (20.4 in)์
๋๋ค. ํ๋ ฅ ์งํ๋ ์ ์ ๋ฒ์์ ์์ต๋๋ค. ์ฌํ ๊ฒ์ฌ์์ ์ข์ธก ์๊ณจ ํ ๋ถ์์์ ๊ฐ์ฅ ์ ๋ค๋ฆฌ๋ 4/6 ๋ฑ๊ธ์ ์ง์์ฑ ์ก์์ด ๋ํ๋ฌ์ต๋๋ค. ์ฌ์ฅ ์ด์ํ ๊ฒ์ฌ๋ฅผ ํตํด ์ง๋จ์ ํ์ธํ ํ, ์ด ํ์์ ๊ด๋ฆฌ์ ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Indomethacin infusion | {
"A": "Prostaglandin E1 ์ฃผ์
",
"B": "Indomethacin ์ฃผ์
",
"C": "์์ ์ ๊ฒฐ์ฐฐ",
"D": "๊ฒฝํผ์ ์์ "
} | step2&3 | B | [
"5 week old infant born",
"36 weeks",
"gestation",
"brought",
"physician",
"well",
"mother reports",
"breastfed",
"15 minutes",
"2 hours",
"now feeds",
"40 minutes",
"4 hours",
"infant",
"six wet diapers",
"two stools daily",
"currently",
"3500 g",
"20",
"length",
"Vital signs",
"normal limits",
"Cardiopulmonary examination shows",
"grade",
"6 continuous murmur heard best",
"left infraclavicular area",
"confirming",
"diagnosis",
"echocardiography",
"following",
"most appropriate next step",
"management",
"patient"
] | 00000000000000000068 |
51์ธ ์ฌ์ฑ ํ์๊ฐ 1์ผ ์ ๋ถํฐ ์์๋ ์ค๋ฅธ์ชฝ ์๊ตฌ๋ฆฌ ํต์ฆ๊ณผ ํ๋จ๋ฅผ ์ฃผ์๋ก ์์ฌ์๊ฒ ๋ด์ํ์๋ค. ์ง๋ 2์ฃผ ๋์, ๊ทธ๋
๋ ๋ํ ์ ์ง์ ์ธ ํ์ง ๋ถ์ข
๊ณผ 3kg(7ํ์ด๋) ์ฒด์ค ์ฆ๊ฐ๋ฅผ ๊ฒช์๋ค. ๊ทธ๋
๋ 10๋
์ ์ ์ง๋จ๋ฐ์ ๋ง์ฑ Bํ ๊ฐ์ผ ๊ฐ์ผ ๋ณ๋ ฅ์ด ์๋ค. ๊ทธ๋
๋ ์ฌ์
์ ์บ๋ฆฌํฌ๋์์์ ๋ด์์ผ๋ก ์์ฃผ ๋นํํ๋ค. ๊ทธ๋
๋ ํผ๋กํด ๋ณด์ธ๋ค. ๋งฅ๋ฐ์ ๋ถ๋น 98ํ, ํธํก์ ๋ถ๋น 18ํ, ํ์์ 135/75 mm Hg์ด๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ๋ ์ฃผ์ ๋ถ์ข
, ๋ณต๋ถ ํฝ๋ง, ๊ทธ๋ฆฌ๊ณ ํ์ง 2+ ๋ถ์ข
์ด ๋ํ๋ฌ๋ค. ํ๋ ์ฒญ์ง์ ๊นจ๋ํ๋ค. ๋ณต๋ถ CT ์ค์บ ๊ฒฐ๊ณผ, ๋ณต์๋ฅผ ๋๋ฐํ ๊ฒฐ์ ์ฑ ๊ฐ, ํ๋ถํ ์ธก๋ถ ํ๊ด์ด ์๋ ํฐ ์ค๋ฅธ์ชฝ ์ ์ฅ, ๊ทธ๋ฆฌ๊ณ ์ค๋ฅธ์ชฝ ์ ์ ๋งฅ์ ์ถฉ๋ง ๊ฒฐ์์ด ๋ํ๋ฌ๋ค. ์๊ฒ์ฌ ๊ฒฐ๊ณผ, 4+ ๋จ๋ฐฑ๋จ, ์์ฑ ํฌ๋๋น, ๊ทธ๋ฆฌ๊ณ ์ง๋ฐฉ ์์ฃผ๊ฐ ๋ํ๋ฌ๋ค. ๋ค์ ์ค ์ด ํ์์ ์ ์ ๋งฅ ์๊ฒฌ์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ์๋ ๊ทผ๋ณธ ์์ธ์ ๋ฌด์์ธ๊ฐ? | Loss of antithrombin III | {
"A": "ํ๋๋ ์ VIII ์ธ์ ๊ฒฐํ",
"B": "์ํฐํธ๋กฌ๋น III ์์ค",
"C": "์์คํธ๋ก๊ฒ ๋ถํด ์ฅ์ ",
"D": "ํญ์ธ์ง์ง ํญ์ฒด"
} | step2&3 | B | [
"year old woman",
"physician",
"1-day history",
"right flank pain",
"bloody urine",
"past 2 weeks",
"progressive lower extremity swelling",
"3 kg",
"weight gain",
"history of chronic hepatitis B infection",
"diagnosed 10 years",
"frequently flies",
"California",
"New York",
"business",
"appears fatigued",
"pulse",
"98 min",
"respirations",
"min",
"blood pressure",
"75 mm Hg",
"Examination shows periorbital edema",
"distended abdomen",
"2",
"edema of",
"lower extremities",
"lungs",
"clear",
"auscultation",
"CT scan",
"abdomen shows",
"nodular liver",
"ascites",
"large right",
"abundant collateral",
"filling defect in",
"right renal vein",
"Urinalysis shows 4",
"protein",
"positive glucose",
"casts",
"following",
"most likely underlying cause",
"patient's renal findings"
] | 00000000000000000069 |
๋ง 57์ธ ๋จ์ฑ์ด ๋ง์ฑ์ ์ธ ํ๊ณจ ๋ค ํต์ฆ์ ๋ํ ์ถ์ ํ๊ฐ๋ฅผ ์ํด ์์ฌ๋ฅผ ์ฐพ์์ต๋๋ค. ํต์ฆ์ ๋ฐค์ ์ฌํด์ง๊ณ ๊ณผ์์ ํ ํ์ ๋ ์ฌํด์ง๋๋ค. ๊ทธ๋ ์๊ฐ์ ๋์ ๊ฒฝ๊ตฌ์ฉ pantoprazole์ ๋ณต์ฉํ์ง๋ง ์ฆ์์ด ์ ํ ์ํ๋์ง ์์์ต๋๋ค. ์๋์์ญ์ด์ง์ฅ ๋ด์๊ฒฝ ๊ฒ์ฌ ๊ฒฐ๊ณผ ์์๋ถ ์๋์ ๊ถค์์ด ๋ํ๋ฌ๊ณ ๊ทผ์๋ถ Z-์ ์ด ์ ์๋์์ต๋๋ค. ์์๋ถ ์๋ ์๊ฒ ๊ฒฐ๊ณผ goblet cells๋ฅผ ๋๋ฐํ ์์ฃผ ์ํผ๊ฐ ๋ํ๋ฌ์ต๋๋ค. ๋ค์ ์ค ์ด๋ค ํ๋ฏธ๊ฒฝ์ ์๊ฒฌ์ด ์ด ํ์์๊ฒ์ ๊ด์ฐฐ๋ ์ธํฌ ๋ณํ์ ๋์ผํ ๋ณํ์๋ฆฌํ์ ๊ธฐ์ ์ ๋ํ๋
๋๊น? | Squamous epithelium in the bladder | {
"A": "๋ฐฉ๊ด์ ํธํ ์ํผ",
"B": "์ญ์ด์ง์ฅ์ Paneth cells",
"C": "๊ณต์ฅ์ ๋ถ์ง๋ muscularis mucosa",
"D": "์๊ถ๊ฒฝ๋ถ ๋ด๋ง์ ๋ฌด์ง์ํ ํธํ ์ํผ"
} | step1 | A | [
"57 year old man",
"physician",
"follow-up evaluation of chronic",
"retrosternal chest pain",
"pain",
"worse",
"night",
"heavy meals",
"taken oral pantoprazole",
"months",
"relief",
"symptoms",
"Esophagogastroduodenoscopy shows ulcerations",
"distal esophagus",
"dislocated Z-line",
"biopsy of",
"distal esophagus shows columnar epithelium",
"cells",
"following microscopic findings",
"same",
"cellular changes seen",
"patient"
] | 00000000000000000070 |
37์ธ ์ฌ์ฑ ํ์๊ฐ 6๊ฐ์ ๋์์ ์ฒด์ค ๊ฐ์, ๋ณต๋ถ ํฝ๋ง๊ฐ ๋ฐ ์ค์ฌ ์ฆ์์ผ๋ก ์์ฌ๋ฅผ ์ฐพ์์ต๋๋ค. ํก์ฐ์ด๋ ์์ฃผ๋ ํ์ง ์์ต๋๋ค. ํ๋ ฅ ์งํ๋ ์ ์ ๋ฒ์ ๋ด์ ์์ต๋๋ค. ํค๋ 173 cm (5 ft 8 in)์ด๊ณ ๋ชธ๋ฌด๊ฒ๋ 54 kg (120 lb)์ด๋ฉฐ, BMI๋ 18 kg/m2์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ๊ฒฐ๋ง์ ์ธก๋์ฝ ๋ฐ์ชฝ์ ์์ธก์ฑ ํฐ ๋ฐ์ , ๊ฑด์กฐํ ํผ๋ถ ๋ฐ ์ฐํ ์ ์์ง์ด์ง ์๋ ์ ๋ฐฉ ์ ์ค์ ์ ๋ฑ๋ฑํ ๊ฒฝ๋ถ ๋ฉ์ด๋ฆฌ๊ฐ ๋ํ๋ฌ์ต๋๋ค. D-์์ผ๋ก์ค ์์ฌ ํ์ ์๋ณ ๊ฒ์ฌ์์ ์ ์ฅ D-์์ผ๋ก์ค ๋ฐฐ์ค ์ฆ๊ฐ๊ฐ ๋ํ๋ฌ์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์ฒด์ค ๊ฐ์๋ฅผ ์๋ฐฉํ์ ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ๋์ ๊ฒ์ ๋ฌด์์
๋๊น? | Pancreatic enzyme replacement | {
"A": "๊ธ๋ฃจํ
ํ๋ฆฌ ๋ค์ด์ดํธ",
"B": "์ท์ฅ ํจ์ ๋์ฒด",
"C": "ํ
ํธ๋ผ์ฌ์ดํด๋ฆฐ ์๋ฒ",
"D": "์ ๋น ํ๋ฆฌ ๋ค์ด์ดํธ"
} | step1 | B | [
"year old woman",
"physician",
"of",
"month history",
"weight loss",
"bloating",
"diarrhea",
"not smoke",
"drink alcohol",
"vital signs",
"normal limits",
"5 ft 8",
"tall",
"54 kg",
"BMI",
"kg/m2",
"Physical examination shows bilateral white spots",
"temporal half",
"conjunctiva",
"dry skin",
"hard neck mass",
"anterior midline",
"not move",
"swallowing",
"Urinalysis",
"a D xylose meal shows",
"increase",
"renal",
"xylose excretion",
"following",
"most likely to",
"prevented",
"patient's weight loss"
] | 00000000000000000071 |
52์ธ ๋จ์ฑ์ด ์ ๊ธฐ ๊ฒ์ง์ ์ํด ๋ด์ํ์์ต๋๋ค. ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ผ๋ก๋ 10๋
์ ์ ์ง๋จ๋ฐ์ 1๊ธฐ ์ ์ ๊ณ ํ์๊ณผ Aํ ๊ฐ์ผ ๊ฐ์ผ์ด ์์ต๋๋ค. ๊ทธ๋ ๋งค์ผ ์์คํผ๋ฆฐ, ๋ก์๋ฐ์คํํด, ์๋ ๋ผํ๋ฆด์ ๋ณต์ฉํ๊ณ , ๋ง๊ทธ๋ค์ ๋ณด์ถฉ์ ๋ฅผ ๊ฐ๋ ๋ณต์ฉํฉ๋๋ค. ๊ทธ๋ ์ผ์ฃผ์ผ๊ฐ์ ํด๊ฐ๋ก ์์ฝฐ๋๋ฅด๋ฅผ ๋ฐฉ๋ฌธํ ์์ ์ด๋ฉฐ ์ฌํ ์ ๋ง๋ผ๋ฆฌ์ ์๋ฐฉ์ ๋ํด ์ฐ๋ คํ๊ณ ์์ต๋๋ค. ์์ฌ๋ ๊ทธ๊ฐ ์์ฝฐ๋๋ฅด์ ์๋ ๋์๊ณผ ์์ฝฐ๋๋ฅด๋ฅผ ๋ ๋ ํ 7์ผ ๋์ ๋งค์ผ 1๊ฐ์ primaquine ์์ฝ์ ๋ณต์ฉํ๋๋ก ๊ถ๊ณ ํ์ต๋๋ค. ์ฌํ 3์ผ์งธ์ ํ์๋ ๊ธ์ฑ ๋ฐ๋ณ ๋ํต, ํ๊ธฐ์ฆ, ์จ๊ฐ์จ, ์๊ฐ๋ฝ๊ณผ ๋ฐ๊ฐ๋ฝ์ด ํ๋๊ฒ ๋ณํ๋ ์ฆ์์ด ๋ํ๋ฉ๋๋ค. ๊ทธ์ ํ์์ 135/80 mm Hg, ์ฌ๋ฐ์๋ 94/๋ถ, ํธํก์๋ 22/๋ถ, ์ฒด์จ์ 36.9โ (98.4โ)์ด๊ณ , ์ค๋ด ๊ณต๊ธฐ์์ ํ์ค ์ฐ์ ํฌํ๋๋ 97%์
๋๋ค. ๊ทธ์ ์คํ์ค ๊ฒ์ฌ๋ฅผ ์ํด ํ์ก์ ์ฑ์ทจํ๋ ๋์ ๊ฐํธ์ฌ๋ ๊ทธ์ ํ์ก์ด ์ด์ฝ๋ฆฟ ๊ฐ์์ ๋ ๋ ๊ฒ์ ํ์ธํฉ๋๋ค. ๋ค์ ์ค ์ด ํ์์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ํ์ ๋ณ์ธ์ ๊ฐ์ฅ ์ ์ค๋ช
ํ๋ ์ง์ ์ ๋ฌด์์
๋๊น? | It is a type B adverse drug reaction. | {
"A": "ํ์์ ์ํ๋ ์ง์ฐ์ผ์ผ๋ก ์ค์ผ๋ ๋ฌผ์ ์ญ์ทจํ๊ธฐ ๋๋ฌธ์
๋๋ค.",
"B": "์ด ์ํ๋ primaquine ๊ณผ๋ค ๋ณต์ฉ์ผ๋ก ์ธํด ๋ฐ์ํ์ต๋๋ค.",
"C": "์ด ์ํ๋ primaquine๊ณผ ๋ง๊ทธ๋ค์ ๋ณด์ถฉ์ ๋ฅผ ๋ณ์ฉํ๊ธฐ ๋๋ฌธ์ ๋ฐ์ํ์ต๋๋ค.",
"D": "์ด๋ Bํ ์ฝ๋ฌผ ๋ถ์์ฉ์
๋๋ค."
} | step1 | D | [
"year old man presents",
"routine checkup",
"Past medical history",
"stage 1 systemic hypertension",
"hepatitis A infection diagnosed 10 years",
"takes aspirin",
"rosuvastatin",
"enalapril daily",
"magnesium supplement",
"planning to visit Ecuador",
"week long vacation",
"concerned",
"malaria prophylaxis",
"travel",
"physician",
"taking 1 primaquine pill",
"day",
"7 consecutive days",
"leaving Ecuador",
"third day",
"trip",
"patient",
"acute headache",
"dizziness",
"shortness of breath",
"fingertips",
"toes turning blue",
"blood pressure",
"80 mm Hg",
"heart rate",
"min",
"respiratory rate",
"min",
"temperature",
"36",
"98",
"blood oxygen saturation",
"97",
"room air",
"drawing blood",
"laboratory workup",
"nurse notes",
"blood",
"chocolate brown color",
"following statements best",
"etiology",
"patients",
"likely condition"
] | 00000000000000000072 |
32์ฃผ ์์ ์ค์ธ 31์ธ ์ฌ์ฑ(์์ 2ํ, ์ถ์ฐ 1ํ)์ด ๊ฐ์์ค๋ฌ์ด ๋ง์ ์ง ๋ถ๋น๋ฌผ ๋์ถ๋ก ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ๊ทธ๋
์ ์์ ์ ํฉ๋ณ์ฆ์ด ์์์ต๋๋ค. ์ฒซ ์์ด๋ ๋ง์ญ์ผ๋ก ์ง์ ๋ถ๋งํ์ต๋๋ค. ๊ทธ๋
๋ ์ฌ๊ฐํ ์ง๋ณ ๋ณ๋ ฅ์ด ์์ต๋๋ค. ๊ทธ๋
๋ ์ ์ ๋ง์๊ฑฐ๋ ๋ด๋ฐฐ๋ฅผ ํผ์ฐ์ง ์์ต๋๋ค. ํ์ฌ ๋ณต์ฉ ์ค์ธ ์ฝ๋ฌผ์๋ ๋นํ๋ฏผ ๋ณด์ถฉ์ ๊ฐ ํฌํจ๋ฉ๋๋ค. ๊ทธ๋
์ ์ฒด์จ์ 37.2ยฐC(98.9ยฐF), ๋งฅ๋ฐ์ 70ํ/๋ถ, ํธํก์๋ 18ํ/๋ถ, ํ์์ 128/82 mm Hg์
๋๋ค. Speculum ๊ฒ์ฌ ๊ฒฐ๊ณผ ์๊ถ๊ฒฝ๋ถ๊ด์์ ๋ง์ ์ก์ฒด๊ฐ ๊ด์ฐฐ๋ฉ๋๋ค. ํ์ ์ฌ๋ฐ์๋ ๊ฐ์ ์์ด 160ํ/๋ถ์ผ๋ก ๋ฐ์์ฑ์ด ์ข์ต๋๋ค. Tocometry๋ ์๊ถ ์์ถ์ ๋ณด์ฌ์ค๋๋ค. Nitrazine ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ์์ฑ์
๋๋ค. Indomethacin ํฌ์ฌ๋ฅผ ์์ํ์ต๋๋ค. ๋ค์ ์ค ๊ฐ์ฅ ์ ์ ํ ๊ด๋ฆฌ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Administer betamethasone and ampicillin | {
"A": "Betamethasone๊ณผ ampicillin์ ํฌ์ฌํ๊ณ ์ ์์ ๊ฐ๋ฅผ ์งํํฉ๋๋ค.",
"B": "Ampicillin์ ํฌ์ฌํ๊ณ ์์ ์ฃผ์
์ ์ํํฉ๋๋ค.",
"C": "Betamethasone๊ณผ ampicillin์ ํฌ์ฌํฉ๋๋ค.",
"D": "Betamethasone, ampicillin์ ํฌ์ฌํ๊ณ ๋ถ๋ง ์ ๋๋ฅผ ์งํํฉ๋๋ค."
} | step2&3 | C | [
"31 year old woman",
"gravida 2",
"para 1",
"weeks",
"gestation",
"emergency department",
"sudden leakage",
"clear vaginal",
"pregnancy",
"uncomplicated",
"first child",
"born",
"term",
"vaginal delivery",
"history",
"serious illness",
"not drink alcohol",
"smoke cigarettes",
"Current medications include vitamin supplements",
"temperature",
"98 9F",
"pulse",
"70 min",
"respirations",
"min",
"blood pressure",
"mm Hg",
"Speculum examination demonstrates clear fluid",
"cervical canal",
"fetal heart rate",
"reactive",
"min",
"decelerations",
"shows uterine contractions",
"testing",
"positive",
"started",
"indomethacin",
"following",
"most appropriate next step",
"management"
] | 00000000000000000073 |
16์ธ ์๋
๊ฐ ์ด๋จธ๋์ ์ฝ ํ ๋ณ์ ๋ชจ๋ ๋ณต์ฉํ๋ค๊ณ ๋งํ๋ ์น๊ตฌ๋ค์ ์ํด ์๊ธ์ค๋ก ์ด์ก๋์์ต๋๋ค. ๊ทธ๋ค์ ๊ทธ๋
๊ฐ ์ญ์ทจํ ์ฝ์ด ๋ฌด์์ธ์ง ์์ง ๋ชปํฉ๋๋ค. ํ์๋ ์์์ ์์๋ค ๋์ฐพ์๋ค ํ๋ฉฐ ์ด๋ ํ ๋ณ๋ ฅ๋ ์ ๊ณตํ ์ ์์ต๋๋ค. ์ฒด์จ์ 39.6ยฐC(103.2ยฐF), ์ฌ๋ฐ์๋ 135/๋ถ, ํ์์ 178/98 mm Hg, ํธํก์๋ 16/๋ถ์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ๋จ๋ฆผ์ด๋ ๊ฐ๋์ฑ ๊ทผ๊ฒฝ๋ จ ์์ด ์ฌ๊ฐํ ๊ทผ์ก ๊ฐ์ง์ด ๋ํ๋ฉ๋๋ค. ๋ค์ ์ค ์ด ํ์์๊ฒ ๊ฐ์ฅ ์ ํฉํ ์น๋ฃ๋ฒ์ ๋ฌด์์
๋๊น? | Dantrolene | {
"A": "๋ ๋ก์",
"B": "๋จํธ๋กค๋ ",
"C": "ํ๋๋ํ",
"D": "์ํ๋กํตํ๋"
} | step1 | B | [
"year old girl",
"brought",
"emergency department",
"friends",
"took",
"whole bottle",
"moms medication",
"not",
"medication",
"ingested",
"patient",
"slipping",
"out",
"consciousness",
"unable to",
"history",
"temperature",
"heart rate",
"min",
"blood pressure",
"98 mm Hg",
"respiratory rate",
"min",
"physical examination",
"significant muscle",
"tremor",
"clonus",
"following",
"best course",
"treatment",
"patient"
] | 00000000000000000074 |
68์ธ ์ฌ์ฑ์ด ๋ฐ์ด, ๊ธฐ์นจ, ๊ทธ๋ฆฌ๊ณ 3์ผ ๋์์ ํธํก๊ณค๋์ผ๋ก ์ธํด ์๊ธ์ค๋ก ์ด์ก๋์์ต๋๋ค. ๊ทธ๋
๋ 3๊ฐ์ ๋์ ์๋ถ ๋ฑ ํต์ฆ์ ๊ฒช๊ณ ์์ผ๋ฉฐ, ํ๋ ํ ํต์ฆ์ด ๋ ์ฌํด์ง๋๋ค. ๊ทธ๋
๋ ํต์ฆ ์ํ๋ฅผ ์ํด ibuprofen์ ๋ณต์ฉํฉ๋๋ค. ๊ทธ๋
๋ ํก์ฐ๋ ฅ์ด ์์ต๋๋ค. ์ฒด์จ์ 39.5ยฐC (103.1ยฐF)์ด๊ณ , ํ์์ 100/70 mm Hg, ๋งฅ๋ฐ์ 95/min, ๊ทธ๋ฆฌ๊ณ ํธํก์๋ 22/min์
๋๋ค. ํ ์ฒญ์ง ์ ์ข์ธก ํ์ฝ ๋ถ์์์ ์ํฌ์์ด ๋ค๋ฆฝ๋๋ค. ํต์ฆ์ด ์๋ ๋ฆผํ์ (1 ร 1 cm)์ด ์ข์ธก ์ก์ ๋ฐ ๊ฒฝ๋ถ ๋ถ์์์ ์ด์ง๋ฉ๋๋ค. ์ฌ๋ฌ ํ์ถ๋ฅผ ๋ฐ๋ผ ์ํต์ด ์์ต๋๋ค. ์คํ์ค ๊ฒ์ฌ๋ ์งํ ์ค์
๋๋ค. ๋๊ฐ๊ณจ X-ray ๋ฐ ํ ์ฐฝ๋ฌธ ํ๋ถ ์ปดํจํฐ ๋จ์ธต ์ดฌ์ ์ค์บ์ด ํ์๋ฉ๋๋ค. ๋ค์ ์ค ์ด๋ค ์งํ์ด ์ด ํ์์ ๊ธ์ฑ ์ํ์ ๊ฐ์ฅ ํฐ ์ญํ ์ ํ์ ๊ฐ๋ฅ์ฑ์ด ๋์ต๋๊น? | Multiple myeloma | {
"A": "Metastatic breast cancer",
"B": "Multiple myeloma",
"C": "Paget's disease",
"D": "Primary hyperparathyroidism"
} | step2&3 | B | [
"68 year old woman",
"brought",
"emergency department",
"fever",
"productive cough",
"dyspnea",
"3 days",
"upper back pain",
"months",
"worse",
"activity",
"takes ibuprofen",
"pain relief",
"history of smoking",
"temperature",
"blood pressure",
"100 70 mm Hg",
"pulse",
"95 min",
"respirations",
"min",
"Lung auscultation shows rales",
"left lower lobe area",
"Painful lymph nodes",
"1",
"1",
"palpated",
"left axillary",
"cervical regions",
"point tenderness",
"thoracic vertebrae",
"Laboratory studies",
"skull X-ray",
"lung window",
"computed tomography scan",
"shown",
"following disorders",
"likely played",
"role",
"patients acute condition"
] | 00000000000000000075 |
22์ธ ์ฌ์ฑ ํ์๊ฐ ์ฌํ ์ํฌ ๋ฐ์์ ์ฃผ ์ฆ์์ผ๋ก ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ํ์๋ 2์ผ ์ ๊ธฐ์ ์ ๊ตฌ๊ฐ ๋ด ๋ค์์ ํต์ฆ์ฑ ์ํฌ๊ฐ ์์์ผ๋ฉฐ, ์ดํ ์ ์ ์ ํผ๋ถ์ ๊ตฌ๊ฐ ์ ๋ง์ ์ํฌ๊ฐ ์ง์์ ์ผ๋ก ๋ฐ์ํ๊ณ ์๋ค๊ณ ์ง์ ํ์ต๋๋ค. ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ ์์ผ๋ฉฐ, ์ด๋ฌํ ์ฆ์์ ๊ฒฝํํ ์ ๋ ์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ๊ฐ๋ฒผ์ด ๋ง์ฐฐ์๋ ์ฝ๊ฒ ๋ถ๋ฆฌ๋๋ ํต์ฆ์ฑ, ์ด์์ฑ ์ํฌ๋ฅผ ๋๋ฐํ ๊ด๋ฒ์ํ ์ํฌ์ฑ ๋ฐ์ง์ด ๊ด์ฐฐ๋์์ต๋๋ค. ์ด ํ์์๊ฒ์ ๋ค์ ๋จ๋ฐฑ์ง ์ค ์ด๋ค ๋จ๋ฐฑ์ง์ ๊ธฐ๋ฅ์ด ๊ฐ์ฅ ํ๊ดด๋์์ ๊ฐ๋ฅ์ฑ์ด ๋์ต๋๊น? | Cadherin | {
"A": "Cadherin",
"B": "Collagen",
"C": "Integrin",
"D": "Keratin"
} | step1 | A | [
"year old woman presents",
"emergency department",
"2-day history",
"severe blistering",
"woke up 2 days",
"number",
"painful blisters",
"mouth",
"since",
"continuing to",
"blisters of",
"cutaneous",
"body",
"the mucosa of",
"mouth",
"past medical history",
"never experienced",
"symptoms",
"Physical exam reveals",
"diffuse vesicular",
"painful",
"flaccid blisters",
"separate easily",
"gentle",
"function",
"following proteins",
"most likely disrupted",
"patient"
] | 00000000000000000076 |
์ํ 3์ฃผ ๋ ๋จ์์์ด๊ฐ 3์ผ ๋์ ์งํ๋ ๋ฌด๊ธฐ๋ ฅ์ฆ๊ณผ ์์ ๊ณค๋์ผ๋ก ์ธํด ๋ถ๋ชจ์ ์ํด ์๊ธ์ค๋ก ์ด์ก๋์๋ค. ์์ด๋ ๋ง์ญ์ ํ์ด๋ฌ์ผ๋ฉฐ ์ด์ ์๋ ์์ ์ ์ด๋ ค์์ด ์์๋ค. ์ฒด์จ์ 39.4ยฐC(103ยฐF), ๋งฅ๋ฐ์ 220/min, ํธํก์ 45/min, ํ์์ 50/30 mm Hg์ด๋ค. 100% ์ฐ์์์์ ๋งฅ๋ฐ ์ฐ์ ์ธก์ ๋ฒ์ ์ฐ์ ํฌํ๋ 97%๋ฅผ ๋ํ๋ธ๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ, ๊ฑด์กฐํ ์ ๋ง, ์ง์ฐ๋ ๋ชจ์ธํ๊ด ์ฌ์ถฉ์ ์๊ฐ, ๊ทธ๋ฆฌ๊ณ ํผ๋ถ ํ๋ ฅ์ด ๊ฐ์๋ ์ฐจ๊ฐ์ด ํผ๋ถ๋ฅผ ๋ณด์ธ๋ค. ๊ฐํธ์ฌ์ ์ฌ๋ฌ ์๋์๋ ๋ถ๊ตฌํ๊ณ , ๋ง์ด ์ ๋งฅ ์ ๊ทผ๋ก๋ฅผ ํ๋ณดํ ์ ์๋ค. ๋ค์ ์ค ๊ด๋ฆฌ์ ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ๋ ๋ฌด์์ธ๊ฐ? | Intraosseous cannulation | {
"A": "๊ทผ์ก ๋ด ์ํผ๋คํ๋ฆฐ",
"B": "๋ด๊ฒฝ์ ๋งฅ ์ฝ๊ด์ ",
"C": "๊ณจ๋ด ์ฝ๊ด์ ",
"D": "์ด์ํ ์ ๋ ์ ์ ์ ๋งฅ ์ฝ๊ด์ "
} | step2&3 | C | [
"3 week old boy",
"brought",
"emergency department",
"parents",
"3-day history",
"progressive lethargy",
"difficulty feeding",
"born",
"term",
"not",
"difficulty feeding",
"temperature",
"4C",
"pulse",
"min",
"respirations",
"min",
"blood pressure",
"50 30 mm Hg",
"Pulse oximetry",
"100",
"oxygen shows",
"oxygen saturation",
"97",
"Examination shows dry mucous membranes",
"delayed capillary refill time",
"cool skin",
"poor turgor",
"multiple attempts",
"nursing staff",
"unable to establish peripheral intravenous access",
"following",
"most appropriate next step",
"management"
] | 00000000000000000077 |
์ด์ ์ ๊ฑด๊ฐํ๋ 10์ธ ์๋
์ด ๋ณตํต๊ณผ ๋ฉ์ค๊บผ์์ด ์์๋ ์ง 5์๊ฐ ํ์ ์ด๋จธ๋์ ์ํด ์๊ธ์ค๋ก ์ด์ก๋์์ต๋๋ค. ์ง๋ 2์ฃผ ๋์ ๊ทธ๋ ๋ํ ์ ์ง์ ์ธ ๋ณตํต๊ณผ 4kg(8.8lb) ์ฒด์ค ๊ฐ์๋ฅผ ๊ฒช์์ต๋๋ค. ์ด๋จธ๋๋ ์๋ค์ด ์ด ๊ธฐ๊ฐ ๋์ ํ์๋ณด๋ค ๋ ๋ง์ ๋ฌผ์ ๋ง์
จ๋ค๊ณ ๋ณด๊ณ ํ์ต๋๋ค. ์ง๋ ์ฃผ์ ๊ทธ๋ 3์ธ๋ถํฐ ์์ ํ ๋ฐฐ๋ณ ํ๋ จ์ ๋ฐ์์์๋ ๋ถ๊ตฌํ๊ณ ์ธ ๋ฒ์ด๋ ์นจ๋์ ์๋ณ์ ๋ดค์ต๋๋ค. ๊ทธ์ ์ฒด์จ์ 37.8ยฐC(100ยฐF), ๋งฅ๋ฐ์ 128/min, ํธํก์๋ 35/min, ํ์์ 95/55 mm Hg์
๋๋ค. ๊ทธ๋ ๋ฌด๊ธฐ๋ ฅํด ๋ณด์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ๊น๊ณ ํ๋ ํธํก๊ณผ ๊ฑด์กฐํ ์ ๋ง์ด ๋ํ๋ฌ์ต๋๋ค. ๋ณต๋ถ๋ ๋ถ๋๋ฝ๊ณ , ์ํต์ ๋ํ ๊ด๋ฒ์ํ ์ํต์ด ์์ง๋ง ๊ฒฝ๊ณ๋ ๋ฐ๋์ ์์ต๋๋ค. ํ์ฒญ ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค.
Na+ 133 mEq/L
K+ 5.9 mEq/L
Cl- 95 mEq/L
HCO3- 13 mEq/L
Urea nitrogen 25 mg/dL
Creatinine 1.0 mg/dL
์ ๊ฒ์ฌ์ง์์ ์ผํค๊ณผ ํฌ๋๋น์ ์์ฑ ๋ฐ์์ ๋ณด์์ต๋๋ค. ์ถ๊ฐ ํ๊ฐ๋ ๋ค์ ์ค ๋ฌด์์ ๋ฐํ๋ผ ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ๋์ต๋๊น?" | Decreased total body potassium | {
"A": "Decreased total body potassium",
"B": "Increased total body sodium",
"C": "Increased arterial pCO2",
"D": "Hypervolemia"
} | step2&3 | A | [
"healthy 10 year old boy",
"brought",
"emergency room",
"mother",
"hours",
"onset",
"abdominal",
"nausea",
"past 2 weeks",
"progressive abdominal pain",
"4 kg",
"8.8",
"weight loss",
"mother reports",
"son",
"drinking more water",
"usual",
"period",
"Last week",
"wet",
"bed three times",
"completely toilet trained since",
"years",
"age",
"temperature",
"pulse",
"min",
"respirations",
"35 min",
"blood pressure",
"95 55 mm Hg",
"appears lethargic",
"Physical examination shows deep",
"labored breathing",
"dry mucous membranes",
"abdomen",
"soft",
"diffuse tenderness",
"palpation",
"guarding",
"Serum laboratory studies show",
"Na",
"mEq/L K",
"5",
"Cl",
"HCO3",
"Urea mg Creatinine 1 0 mg dL Urine dipstick",
"positive",
"ketones",
"glucose",
"Further evaluation",
"most likely to reveal",
"following"
] | 00000000000000000078 |
70์ธ ๋ฐฑ์ธ ๋จ์ฑ์ด ๋ด์ ์ฌ์ฅ ํํ 4๋จ๊ณ ์ธํ์ฑ ์ฌ๋ถ์ ์น๋ฃ๋ฅผ ์ํด ๊ทํ์ ์ง๋ฃ์ค์ ์ ๊ธฐ์ ์ผ๋ก ๋ฐฉ๋ฌธํฉ๋๋ค. ๋ค์ ์ฝ๋ฌผ ์ค ์ด ๋จ์ฑ์ ์ฝ๋ฌผ ์๋ฒ์ ์ถ๊ฐํ์ฌ ์ ๋ฐ์ ์ธ ์์กด์จ์ ๊ฐ์ ํ ์ ์๋ ์ฝ๋ฌผ์ ๋ฌด์์
๋๊น? | Spironolactone | {
"A": "Spironolactone",
"B": "Amiloride",
"C": "Hydrochlorothiazide",
"D": "Acetazolamide"
} | step1 | A | [
"70 year old Caucasian male visits",
"office",
"treatment",
"New York Heart association class IV",
"congestive",
"failure",
"following medications",
"add",
"man's drug regimen",
"order to",
"overall survival"
] | 00000000000000000079 |
์ง์ ๋ถ๋ง ํ ์ ์๊ฐ ๋ค, ๋ง์ญ์ผ๋ก ํ์ด๋ ๋จ์์๊ฒ ๋น๋งฅ ๋ฐ ๋นํธํก์ด ๋ํ๋๋ค. ๊ทธ์ ํ์์ ์ ์ ๋ฒ์ ๋ด์ ์๋ค. ์ค๋ด ๊ณต๊ธฐ์์ ๋งฅ๋ฐ ์ฐ์ ์ธก์ ๋ฒ์ ์ค๋ฅธ์ชฝ ์์์ 79%, ์ผ์ชฝ ๋ฐ์์ 61%์ ์ฐ์ ํฌํ๋๋ฅผ ๋ํ๋ธ๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ์ผ๊ตด๊ณผ ๋ชธํต์ ํธ๋ฅด์ค๋ฆํ ๋ณ์, ์๊ณจ ์ ๋ฐ ๋๊ฐ ํจ๋ชฐ, ๊ทธ๋ฆฌ๊ณ ์ฌ์ฅ ๋ถ์์์ ๊ธฐ๊ณ ์๋ฆฌ๊ฐ ๋ค๋ฆฐ๋ค. ๋ณ์ ์ฌ์ฅ ์ด์ํ ๊ฒ์ฌ ๊ฒฐ๊ณผ ํ ๋ฐ ์ ์ ์ํ์ด ์ง๋ ฌ์ด ์๋ ๋ณ๋ ฌ๋ก ๋ํ๋๋ค. ์ด ํ์์๊ฒ ๊ฐ์ฅ ์ ์ ํ ์ฝ๋ฌผ ์น๋ฃ๋ฒ์ ๋ฌด์์ธ๊ฐ? | Alprostadil | {
"A": "์ค๋ฐ๋ํ",
"B": "์ํ๋ก์คํ๋",
"C": "๋ฉํ ํ๋กค๋กค",
"D": "์ธ๋๋ฉํ์ "
} | step1 | B | [
"Several hours",
"vaginal delivery",
"male newborn delivered",
"full-term",
"tachycardia",
"tachypnea",
"blood pressure",
"normal limits",
"Pulse oximetry",
"room air shows",
"oxygen saturation",
"right hand",
"61",
"left foot",
"Physical examination shows",
"discoloration",
"face",
"trunk",
"supraclavicular",
"intercostal retractions",
"machine",
"murmur",
"precordium",
"echocardiography shows pulmonary",
"systemic circulation",
"in parallel",
"in series",
"most appropriate pharmacotherapy",
"patient"
] | 00000000000000000080 |
5์ธ ๋จ์๊ฐ ๊ฑด๊ฐ ๊ฒ์ง์ ์ํด ์์๊ณผ๋ฅผ ๋ฐฉ๋ฌธํ์ต๋๋ค. ์ ์ฅ์ ํด๋น ์ฐ๋ น์ 99๋ฒ์งธ ๋ฐฑ๋ถ์์ ํด๋นํ๋ฉฐ, ์ ์ฒด ๊ฒ์ฌ์์ ์๋ชจ๊ฐ ๊ด์ฐฐ๋์์ต๋๋ค. ํ์ฒญ ๋ ๋ ๋ฐ ์นผ๋ฅจ ์์น๊ฐ ๋๊ณ , 17-hydroxyprogesterone ์์น ๋ํ ๋์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์๊ฒ ๊ฒฐํ๋์์ ๊ฐ๋ฅ์ฑ์ด ์๋ ๊ฒ์ ๋ฌด์์
๋๊น? | 21-hydroxylase | {
"A": "17a-hydroxylase",
"B": "21-hydroxylase",
"C": "Aromatase",
"D": "5a-reductase"
} | step1 | B | [
"5 year old male visits",
"pediatrician",
"check-up",
"height",
"99th percentile",
"age",
"pubic hair",
"present",
"physical examination",
"Serum renin",
"potassium levels",
"high",
"17-hydroxyprogesterone",
"following",
"likely deficient",
"patient"
] | 00000000000000000081 |
41์ธ์ ์ํ๋ฆฌ์นด๊ณ ๋ฏธ๊ตญ์ธ ์ฌ์ฑ์ด ์ฐ์ธ์ฆ๊ณผ ๋ถ์์ ๋ํ ํ๊ฐ๋ฅผ ์ํด ๋จํธ๊ณผ ํจ๊ป ์ฃผ์น์์๊ฒ ๋ด์ํ์ต๋๋ค. ๊ทธ๋
๋ ๋ช
ํํ ์ ๋ฐ ์์ธ ์์ด 2์ฃผ ๋์ ๊ธ๊ฒฉํ๊ฒ ์์๋ ์ฌํ์ ํธ์ํฉ๋๋ค. ๊ทธ๋
๋ ๋จํธ๊ณผ ๋ํํ์ผ๋ฉฐ, ๋จํธ์ ๊ทธ๋
์๊ฒ ์ง๋ 2๋
๋์ ์ต์ 3๋ฒ์ ์ ์ฌํ ์ฆ์์ด ๋ฐ์ํ๋ค๊ณ ์ธ๊ธํ์ต๋๋ค. ๊ทธ๋ ๋ํ ๊ทธ๋
๊ฐ ์ต๊ทผ์ "๋ ๊ฐ์ ์ "์ด์๊ณ ํ๋ฃจ ์ข
์ผ ํผ๋์ค๋ฌ์ ๋ณด์ธ๋ค๊ณ ์ธ๊ธํ์ต๋๋ค. ๊ทธ๋
๋ ์๋
์ ์ด๋ฑํ๊ต์์ ์ฌ์๋ก ์ผํ๋ ์ง์ฅ์ ๊ทธ๋ง๋์ด์ผ ํ์ต๋๋ค. ๊ทธ๋
์ ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ ์์ธ ๋ถ๋ช
์ ์ฌ๋ฐ์ฑ ๋ณตํต ์ํผ์๋๋ก ์ธํ ๋ ๋ฒ์ ์ง๋จ์ laparoscopies๋ก ์ฃผ๋ชฉํ ๋งํฉ๋๋ค. ๊ทธ๋
์ ๊ฐ์กฑ๋ ฅ์ ๊ทธ๋
์ ์ด๋จธ๋์ ์ธํ ์๋ฒ์ง์ psychosis๋ก ์ฃผ๋ชฉํ ๋งํฉ๋๋ค. ๊ทธ๋
์ ์ฒด์จ์ 99ยฐF (37.2ยฐC)์ด๊ณ , ํ์์ 125/75 mmHg, ๋งฅ๋ฐ์ 75/min, ํธํก์๋ 17/min์
๋๋ค. ๊ฒ์ง ๊ฒฐ๊ณผ, ๊ทธ๋
๋ ํํด์ด์ ธ ์๊ณ ํผ๋์ค๋ฝ๊ณ ๋ฐฉํฅ ๊ฐ๊ฐ์ ์์คํ ๊ฒ์ฒ๋ผ ๋ณด์
๋๋ค. ๊ทธ๋
์ ์ฃผ์ ์ง์ค ์๊ฐ์ ์ ํ์ ์ด๋ฉฐ ๊ฐ์ ๋ถ์์ ์ ๋ณด์
๋๋ค. ์ด ํ์์ ์ํ๋ ๋ค์ ํํฉ๋ฌผ์ ๋์ฌํ๋ ํจ์์ ๊ฒฐํจ์ผ๋ก ์ธํด ๋ฐ์ํ์ ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ํฝ๋๋ค. | Porphobilinogen | {
"A": "Coproporphyrinogen III",
"B": "Hydroxymethylbilane",
"C": "Porphobilinogen",
"D": "Protoporphyrin IX"
} | step1 | C | [
"year old African American woman presents",
"husband",
"primary care doctor",
"evaluation",
"depression",
"anxiety",
"reports",
"2-week history",
"rapid onset sadness",
"clear",
"factor",
"husband",
"notes",
"three similar episodes",
"occurred",
"past two years",
"notes",
"more emotional",
"confused",
"day",
"to leave",
"job",
"librarian",
"childs elementary school",
"past medical history",
"notable",
"two diagnostic laparoscopies",
"recurrent episodes of abdominal pain",
"unknown etiology",
"family history",
"notable",
"psychosis",
"mother",
"maternal grandfather",
"temperature",
"blood pressure",
"75 mmHg",
"pulse",
"75 min",
"respirations",
"min",
"exam",
"appears confused",
"disoriented",
"attention span",
"limited",
"exhibits emotional lability",
"patients condition",
"most likely due to",
"defect",
"enzyme",
"following compounds"
] | 00000000000000000082 |
32์ธ ์ฌ์ฑ ํ์๊ฐ ์ผ๋ฐ ๊ฑด๊ฐ ๊ฒ์ง์ ์ํด ์ฃผ์น์๋ฅผ ๋ฐฉ๋ฌธํ์ต๋๋ค. ํ์๋ ํ์ฌ ์๋ฌด๋ฐ ๋ถ๋ง์ ํธ์ํ์ง ์์ผ๋ฉฐ, ๋จ์ง ์์ ์ด ๊ฑด๊ฐํ ์ํ์ธ์ง ํ์ธํ๊ณ ์ถ์ดํฉ๋๋ค. ํ์๋ ๊ณผ๊ฑฐ์ ์ฒ์, ๊ณ ํ์, ๋ถ์ ์ฆ์ธ๋ฅผ ๋ณด์ธ ๋ณ๋ ฅ์ด ์์ต๋๋ค. ํ์ฌ ๋ณต์ฉ ์ค์ธ ์ฝ๋ฌผ์ albuterol, fluticasone, hydrochlorothiazide, lisinopril, fexofenadine์
๋๋ค. ์ฒด์จ์ 99.5ยฐF (37.5ยฐC), ํ์์ 165/95 mmHg, ๋งฅ๋ฐ์ 70/min, ํธํก์๋ 15/min, ์ค๋ด ๊ณต๊ธฐ ์ค ์ฐ์ ํฌํ๋๋ 98%์
๋๋ค. ์ง์ฐฐ ๊ฒฐ๊ณผ, ๊ฑด๊ฐํ ์ฒด๊ฒฉ์ ์ ์ ์ฌ์ฑ์ผ๋ก ๋ณด์
๋๋ค. ์ฌ์ฅ ๊ฒ์ฌ์์ ์ ์์ ์ธ ์๋์ S1 ๋ฐ S2 ์ฌ์์ ํ์ธํ์ต๋๋ค. ํ ๊ฒ์ฌ ๊ฒฐ๊ณผ ์์ชฝ ํ์์ ์ฒญ์ง ์ ๊นจ๋ํ๋ฉฐ ๊ณต๊ธฐ ํ๋ฆ์ด ์ํธํฉ๋๋ค. ๋ณต๋ถ ๊ฒ์ฌ ๊ฒฐ๊ณผ ์ก์(bruit)์ด ๋ค๋ฆฌ๊ณ , ์ ์์ ์ธ ์ฅ์(normoactive bowel sounds)์ด ๋ค๋ฆฌ๋ฉฐ, ์ฒญ์ทจ ๊ฐ๋ฅํ ๋ณด๋ฅด๋ณด๋ฆฌ๊ทธ๋ฏธ(borborygmus)๊ฐ ์์ต๋๋ค. ์ ๊ฒฝํ์ ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋์ ๊ฒฝ II-XII๋ ๋๋ ทํ๊ฒ ์จ์ ํ๋ฉฐ ์์ง ๋ฐ ํ์ง์ ๊ทผ๋ ฅ๊ณผ ๋ฐ์ฌ๊ฐ ์ ์์
๋๋ค. ๋ค์ ์ค ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ์ ๊ด๋ฆฌ๋ ๋ฌด์์
๋๊น? | Ultrasound with doppler | {
"A": "lisinopril ์ฉ๋ ์ฆ๊ฐ",
"B": "furosemide ์ถ๊ฐ",
"C": "๋ํ๋ฌ ์ด์ํ",
"D": "์ถ๊ฐ์ ์ธ ๊ด๋ฆฌ ๋ถํ์"
} | step2&3 | C | [
"year old woman presents",
"primary care physician",
"general wellness appointment",
"patient",
"complaints currently",
"to",
"sure",
"good health",
"patient",
"past medical",
"hypertension",
"anxiety",
"current medications include albuterol",
"fluticasone",
"hydrochlorothiazide",
"lisinopril",
"fexofenadine",
"temperature",
"99",
"blood pressure",
"95 mmHg",
"pulse",
"70 min",
"respirations",
"min",
"oxygen saturation",
"98",
"room air",
"exam",
"note",
"healthy young woman",
"Cardiac exam reveals",
"S1",
"S2 heart",
"normal",
"Pulmonary exam",
"clear",
"auscultation",
"good air movement",
"Abdominal exam reveals",
"bruit",
"bowel sounds",
"borborygmus",
"Neurological exam reveals cranial nerves II XII",
"intact",
"normal strength",
"reflexes",
"upper",
"lower extremities",
"following",
"best next step",
"management"
] | 00000000000000000083 |
46์ธ ๋จ์ฑ์ด 10์ผ๊ฐ ์ง์๋ ์ฐ์ ๋ณต๋ถ ํต์ฆ์ผ๋ก ์๊ธ์ค์ ๋ด์ํ์๋ค. ๊ทธ๋ ๋ํ ์ง๋ 6์ฃผ ๋์ ํผ๋ก๊ฐ๊ณผ ๋ฉ์ค๊บผ์์ ๋๊ปด์๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ, ๊ณต๋ง ํฉ๋ฌ์ด ๋ํ๋ฌ๋ค. ๋ณต๋ถ ๊ฒ์ฌ์์ ์ฐ์ ๋ณต๋ถ ์ํต์ด ๋ํ๋ฌ๋ค. ๊ฐ ๊ฐ์ฅ์๋ฆฌ๋ ์ฐ์ธก ๋๊ณจ ํ์ฐ์์ 2cm ์๋์์ ์ด์ง๋์๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ๋ค.
Aspartate aminotransferase 1780 U/L
Alanine aminotransferase 2520 U/L
Hepatitis A IgM antibody ์์ฑ
Hepatitis B surface antigen ์์ฑ
Hepatitis B surface antibody ์์ฑ
Hepatitis B core IgM antibody ์์ฑ
Hepatitis C antibody ์์ฑ
Hepatitis C RNA ์์ฑ
๋ค์ ์ค ์ด ํ์์๊ฒ ๊ฐ์ฅ ์ ์ ํ ์กฐ์น๋ ๋ฌด์์ธ๊ฐ?" | Supportive therapy | {
"A": "Ribavirin and interferon",
"B": "Supportive therapy",
"C": "Emergency liver transplantation",
"D": "Pegylated interferon-alpha"
} | step1 | B | [
"year old man",
"emergency department",
"a 10 day history",
"right upper quadrant abdominal pain",
"feeling tired",
"nauseous",
"past",
"weeks",
"examination",
"scleral icterus",
"present",
"Abdominal examination shows tenderness",
"palpation",
"right upper quadrant",
"liver edge",
"palpated 2 cm",
"right costal margin",
"Laboratory studies show",
"U",
"2520",
"Hepatitis A",
"antibody",
"Positive",
"RNA",
"following",
"best course",
"action",
"patient"
] | 00000000000000000084 |
์ต๊ทผ ๋์ด์ง๋ฆฌ์์์ ์ด๋ฏผ ์จ 5์ธ ๋จ์์์ด๊ฐ ํ์ฒด ์ ์ฝ, ์ผํด ๊ณค๋, ํ์ก ๊ณผ๋ค ๋ถ๋น์ 2์ผ๊ฐ์ ๋ณ๋ ฅ์ ์ด์ ๋ก ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ๊ทธ๋ ์์ง ์ด๋ ํ ์์ ์๋ฐฉ ์ ์ข
๋ ๋ฐ์ง ์์์ต๋๋ค. ์
์ ์ดํ ํ, ํ์๋ ํธํก ๊ณค๋์ ๊ฒช์ต๋๋ค. ๋งฅ๋ฐ ์ฐ์ ์ธก์ ๋ฒ์ 64%์ ์ฐ์ ํฌํ๋๋ฅผ ๋ณด์
๋๋ค. ์์ ๋
ธ๋ ฅ์๋ ๋ถ๊ตฌํ๊ณ , ํ์๋ ํธํก ๋ถ์ ์ผ๋ก ์ฌ๋งํฉ๋๋ค. ๋ถ๊ฒ์์ ์ฒ์ ๊ฒ์ฌ๋ ์ ๊ฐ ์ธํฌ์ ํ๊ดด๋ฅผ ๋ณด์ฌ์ค๋๋ค. ์ด ํ์์ ์ ๊ฒฝํ์ ๊ฒ์ฌ๋ ๋ค์ ์๊ฒฌ ์ค ์ด๋ค ๊ฒ์ ๊ฐ์ฅ ์ ๋ณด์ฌ์ฃผ์์ ๊ฐ๋ฅ์ฑ์ด ์์ต๋๊น? | Hyporeflexia | {
"A": "๋ฐ๋น์คํค ์งํ ์์ฑ",
"B": "์ ๋ฐ์ฌ",
"C": "๊ทผ๊ฐ๋์ฑ ๊ฒฝ๋ จ",
"D": "ํ๋ด ๋ณ์"
} | step1 | B | [
"5 year old boy",
"recently",
"Nigeria",
"brought",
"emergency department",
"of",
"2-day history",
"lower leg weakness",
"swallowing difficulty",
"drooling",
"saliva",
"not",
"received",
"childhood vaccinations",
"Two days",
"admission",
"patient",
"shortness of breath",
"Pulse oximetry shows",
"oxygen saturation",
"64",
"resuscitative efforts",
"patient dies",
"respiratory failure",
"autopsy",
"examination",
"spinal cord shows destruction of",
"anterior horn cells",
"Neurological examination",
"patient",
"most likely shown",
"following findings"
] | 00000000000000000085 |
30์ธ ์ฌ์ฑ ํ์๊ฐ ๋จํธ๊ณผ ํจ๊ป ์๊ธ ์ง๋ฃ์ค์ ๋ด์ํ์ต๋๋ค. ํ์๋ ์
์ ์ฃผ์์ ๋ฌด๊ฐ๊ฐ๊ณผ ์๊ณผ ๋ฐ์ ๋ฐ๋๊ฑฐ๋ฆผ์ ํธ์ํฉ๋๋ค. ํ์๋ ํ ๋ฌ ์ ์ ๋น๋ํด์ง ๊ฐ์์ ๋๋ฌธ์ ๊ฑฐ์ ์์ ํ ๊ฐ์์ ์ ์ ์ ์ ๋ฐ์์ต๋๋ค. ํ๋ ฅ ์งํ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค: ํ์์ 130/70 mm Hg, ๋งฅ๋ฐ์ 72/min, ํธํก์๋ 16/min, ์ฒด์จ์ 37.0ยฐC (98.6ยฐF)์
๋๋ค. ๋ชฉ ์์ชฝ์ ์์ ์ ๊ฐ ํํฐ๊ฐ ์์ต๋๋ค. ๋ด๋น ์์ฌ๋ ํ์ ์ปคํ๋ฅผ 150 mm Hg ์ด์์ผ๋ก ๋ถํ๋ฆฌ๊ณ ํ์์ ์ธก์ ํ๋ฉด์ ๋ช ๋ถ ๋์ ํ์๋ฅผ ๊ด์ฐฐํฉ๋๋ค. ํ์๋ ์์ ๊ฐ์์ค๋ฌ์ด ๊ฒฝ์ง๊ณผ ๋ฐ๋๊ฑฐ๋ฆผ์ ๋ณด์
๋๋ค. ํ์ก ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค:
Hemoglobin (Hb%) 10.2 g/dL
White blood cell count 7000/mm3
Platelet count 160,000/mm3
Calcium, serum (Ca2+) 6.0 mg/dL
Albumin 4 g/dL
Alanine aminotransferase (ALT), serum 15 U/L
Aspartate aminotransferase (AST), serum 8 U/L
Serum creatinine 0.5 mg/dL
Urea 27 mg/dL
Sodium 137 mEq/L
Potassium 4.5 mEq/L
Magnesium 2.5 mEq/L
์๋ณ ๊ฒ์ฌ์์ ๋ฐฑํ๊ตฌ ๋๋ ์ ํ๊ตฌ๋ ๋ํ๋์ง ์์๊ณ , ๋ฐฑํ๊ตฌ ์์คํ
๋ผ์ ๋ ์์ฑ์ด์์ต๋๋ค. ์ด ํ์์ ๊ด๋ฆฌ์ ์์ด ๋ค์์ผ๋ก ๊ฐ์ฅ ์ ์ ํ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Serum parathyroid hormone (PTH) level | {
"A": "CT scan abdomen with pancreatic protocol",
"B": "Serum vitamin D level",
"C": "24-hour urinary calcium",
"D": "Serum parathyroid hormone (PTH) level"
} | step1 | D | [
"30 year old woman",
"brought",
"urgent care clinic",
"husband",
"numbness",
"lips",
"tingling",
"hands",
"feet",
"total thyroidectomy",
"enlarged thyroid gland",
"month",
"Vital signs include",
"blood pressure",
"70 mm Hg",
"pulse",
"72 min",
"respiratory rate",
"min",
"temperature",
"98",
"surgical scar",
"present",
"anterior aspect",
"neck",
"attending physician",
"blood pressure cuff",
"mm Hg",
"observes",
"patient",
"couple",
"minutes",
"measuring",
"blood pressure",
"patient",
"sudden stiffness",
"tingling",
"hand",
"Blood test results",
"follows",
"Hemoglobin",
"Hb",
"g",
"White blood cell count",
"Platelet",
"Calcium",
"serum",
"Ca2",
"6 0 mg/dL Albumin 4 g",
"Alanine aminotransferase",
"ALT",
"serum",
"U/L Aspartate aminotransferase",
"AST",
"serum",
"U",
"creatinine 0.5",
"dL",
"Sodium",
"Potassium",
"Magnesium 2",
"Urinalysis shows",
"white",
"red blood cells",
"leukocyte esterase",
"negative",
"following",
"next best step",
"management",
"patient"
] | 00000000000000000086 |
๊ด์ ๋๋งฅ ์งํ์ ์๊ณ ์๋ ํ ์ฌ์ฑ์ด ์ฐ์ฑ
์ ์์ํ๋ ค ํฉ๋๋ค. ๊ฑท๊ธฐ ์์ํ๋ฉด์, ๊ทธ๋
์ ์ฌ๋ฐ์๋ ๋ถ๋น 60ํ์ ์์ ์ ๋งฅ๋ฐ์์ ๋ถ๋น 120ํ์ ๋๋ฌํ ๋๊น์ง ๋นจ๋ผ์ง๋ฉฐ, ์ด ์์ ์์ ๊ทธ๋
๋ ๊ฐ์ด์ ์กฐ์ฌ์ง์ ๋๋ผ๊ธฐ ์์ํฉ๋๋ค. ๊ทธ๋
๋ ํด์์ ์ํด ๊ฑท๊ธฐ๋ฅผ ๋ฉ์ถ๊ณ ์กฐ์ฌ์ง์ ์ฌ๋ผ์ง๋๋ค. ์ด๋ ์ง๋ 6๊ฐ์ ๋์ ๊ทธ๋
์๊ฒ ์ง์์ ์ผ๋ก ๋ฐ์ํด ์์ต๋๋ค. ๋ค์ ์ค ์ฌ์ค์ธ ์ง์ ์ ๋ฌด์์
๋๊น? | Increasing the heart rate decreases the relative amount of time spent during diastole | {
"A": "์ฌ๋ฐ์ ์ฆ๊ฐ๊ฐ ๊ฐ ์ฌ์ฅ ์ฃผ๊ธฐ ๋์ ์์๋๋ ์๊ฐ์ ์ฆ๊ฐ์ํจ๋ค",
"B": "์ฌ๋ฐ์ ์ฆ๊ฐ๊ฐ ์ด์๊ธฐ ๋์ ์์๋๋ ์๋์ ์๊ฐ์ ๊ฐ์์ํจ๋ค",
"C": "์ฌ๊ทผ ๊ด๋ฅ๋ ์ฃผ๋ก ์์ถ๊ธฐ ๋์ ๋ฐ์ํ๋ค",
"D": "์ฌ๊ทผ ๊ด๋ฅ๋ ์ฌ์ฅ ์ฃผ๊ธฐ ์ ์ฒด์ ๊ฑธ์ณ ๋์ผํ๊ฒ ๋ฐ์ํ๋ค"
} | step1 | B | [
"woman",
"coronary artery disease",
"starting to go",
"walk",
"begins",
"heart rate accelerates",
"resting pulse",
"60",
"reaches",
"rate",
"point",
"begins to feel",
"chest",
"stops walking to rest",
"resolves",
"last",
"months",
"following",
"true statement"
] | 00000000000000000087 |
22์ธ ์ฌ์ฑ ํ์๊ฐ ์ง ๋ถ๋น๋ฌผ, ๊ฐ๋ ค์์ฆ, ์๊ทน ์ฆ์ ํ๊ฐ๋ฅผ ์ํด ์์ฌ์๊ฒ ๋ด์ํ์ต๋๋ค. ํ์๋ ์ต๊ทผ ๋จ์์น๊ตฌ์ ์๋ก์ด ๊ด๊ณ๋ฅผ ์์ํ์ผ๋ฉฐ, ๋จ์์น๊ตฌ๊ฐ ์ ์ผํ ์ฑ ํํธ๋์
๋๋ค. ๋จ์์น๊ตฌ๋ ๋น๋จ์์๊ธฐ ์ฆ์์ ํธ์ํ์ง ์์ต๋๋ค. ํ์๋ ๊ฒฝ๊ตฌ ํผ์์ฝ์ ๋ณต์ฉํ๊ณ ์์ผ๋ฉฐ, ์ฅ๋ฒฝ ํผ์๋ฒ์ ์ฌ์ฉํ์ง ์์ต๋๋ค. ๋ณ๋ ฅ์ ํน์ด ์ฌํญ์ด ์์ต๋๋ค. ํ๋ ฅ ์งํ๋ ์ ์ ๋ฒ์ ๋ด์ ์์ต๋๋ค. ๋ถ์ธ๊ณผ ๊ฒ์ฌ ๊ฒฐ๊ณผ, ์๊ณ ๋
ธ๋์์ ๊ฑฐํ์ด ์๋ ์ง ๋ถ๋น๋ฌผ๊ณผ ๊ณฐํก์ด ๋์, ๋ถ์พํ ๋์, ๊ทธ๋ฆฌ๊ณ ์๊ถ๊ฒฝ๋ถ ์ธ๋ฉด์ ๋ค์์ ์ ์ ๋ถ์ ๋ฐ์ ์ด ๊ด์ฐฐ๋์์ต๋๋ค. ๋๋จธ์ง ๊ฒ์ฌ๋ ์ ์์
๋๋ค. ๋ค์ ์ค ์ด๋ค ๋ฏธ์๋ฌผ์ด ์ต์ ๋๋ง ํ๋ฏธ๊ฒฝ ๊ฒ์ฌ์์ ๊ฐ์ฅ ๋์ ํ๋ฅ ๋ก ๋ํ๋ ๊น์? | Motile round or oval-shaped microorganisms | {
"A": "์นํธ๋ ํจ๋ชจ ์ธํฌ ๋ฐ/๋๋ ๊ฐ์ฌ์๊ท ",
"B": "๋ค์์ ์ธ๊ท ์ธํฌ๋ก ๋ฎ์ธ ์ํผ ์ธํฌ",
"C": "์ด๋์ฑ์ด ์๋ ๋ฅ๊ธ๊ฑฐ๋ ํ์ํ ๋ชจ์์ ๋ฏธ์๋ฌผ",
"D": "์ฐ์์ ๊ตฌ๊ท "
} | step2&3 | C | [
"year old female presents",
"physician",
"evaluation",
"vaginal discharge",
"itching",
"irritation",
"recently started",
"new relationship",
"boyfriend",
"only sexual partner",
"not report",
"genitourinary symptoms",
"takes oral contraceptives",
"not use",
"barrier contraception",
"medical history",
"unremarkable",
"vital signs",
"normal limits",
"gynecologic examination reveals",
"thin",
"yellow",
"frothy vaginal discharge",
"musty",
"odor",
"numerous punctate red maculae",
"ectocervix",
"exam",
"normal",
"following organisms",
"most likely",
"revealed",
"wet mount microscopy"
] | 00000000000000000088 |
๊ณ ํ์๊ณผ ๊ณ ์งํ์ฆ์ ์๊ณ ์๋ 53์ธ ์ฌ์ฑ์ด ์ง๋ 2์ฃผ ๋์ ํผ๋ถ์ ์ ๋ฐ์ ์ธ ๋ฐ์ ๊ณผ ๊ฐ๋ ค์์ฆ์ผ๋ก ์ธํด ์์ฌ๋ฅผ ์ฐพ์๋ค. ๊ทธ๋
์ ์ฆ์์ ๋งค์ผ ์ ๋
์ ์๋ฆฌ์ ๋ค๊ธฐ ์ ์ ๋ฐ์ํ์ฌ ์ฝ 30๋ถ ๋์ ์ง์๋๋ค. 3๊ฐ์ ์ , atorvastatin์ ๋ชฉ๊ณผ ํ๋ฆฌ ํต์ฆ์ด ์ ์ฐจ ์
ํ๋ ํ ์ค๋จ๋์๋ค. ์คํํด ์๋ฒ์ 3์ฃผ ์ ์ ๋ ๋ฎ์ ์ฉ๋์ผ๋ก ์ฌ๊ฐ๋์์ง๋ง ๊ทผ๊ณจ๊ฒฉ ์ฆ์์ด ์ฌ๋ฐํ์ฌ ๋ค์ ์ค๋จํด์ผ ํ๋ค. ๊ทธ๋
์ ์๊ฒฝ์ 2~3๊ฐ์ ๊ฐ๊ฒฉ์ผ๋ก ๋ถ๊ท์นํ๊ฒ ๋ํ๋๋ฉฐ 3~4์ผ ๋์ ์ง์๋๋ค. ๊ทธ๋
๋ ์ง๋ 30๋
๋์ ๋งค์ผ ํ ๊ฐ์ ๋ด๋ฐฐ๋ฅผ ํผ์ ๋ค. ํ์ฌ ๋ณต์ฉํ๋ ์ฝ๋ฌผ์๋ lisinopril๊ณผ niacin์ด ์๋ค. ๊ทธ๋
์ ํ์ ๋ ๊ฒฐ์ฅ ์ ์์ข
์ผ๋ก ์ฌ๋งํ๊ณ , ๊ทธ๋
์ ์๋ฒ์ง๋ ์์ธํฌ ํ์์ผ๋ก ์ฌ๋งํ๋ค. ๊ทธ๋
์ ํค๋ 169cm(5ํผํธ 6์ธ์น)์ด๊ณ ๋ชธ๋ฌด๊ฒ๋ 83kg(183lb)์ด๋ฉฐ, BMI๋ 29kg/m2์ด๋ค. ํ๋ ฅ ์งํ๋ ์ ์ ๋ฒ์ ๋ด์ ์๋ค. ์ ์ฒด ๊ฒ์ฌ์์๋ ์ด์์ด ๋ฐ๊ฒฌ๋์ง ์์๋ค. ํ์ฒญ ์ง์ง ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ๋ค.
์ด ์ฝ๋ ์คํ
๋กค 247mg/dL
HDL-์ฝ๋ ์คํ
๋กค 39mg/dL
LDL-์ฝ๋ ์คํ
๋กค 172mg/dL
ํธ๋ฆฌ๊ธ๋ฆฌ์ธ๋ฆฌ๋ 152mg/dL
๋ค์ ์ค ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ์ ๊ด๋ฆฌ๋ ๋ฌด์์ธ๊ฐ?" | Administer ibuprofen | {
"A": "ibuprofen ํฌ์ฌ",
"B": "์๋ณ hydroxyindoleacetic acid ์์น ์ธก์ ",
"C": "์๋ณ metanephrine ์์น ์ธก์ ",
"D": "niacin์ fenofibrate๋ก ์ ํ"
} | step2&3 | A | [
"year old woman",
"hypertension",
"hyperlipidemia",
"physician",
"generalized reddening",
"skin",
"itching",
"past 2 weeks",
"symptoms occur",
"evening",
"bedtime",
"last",
"30 minutes",
"Three months",
"atorvastatin",
"stopped",
"experienced",
"worsening neck",
"back pain",
"Statin therapy",
"lower doses",
"weeks",
"to",
"stopped",
"musculoskeletal symptoms recurred",
"menses occur",
"23 month intervals",
"last",
"days",
"smoked one pack",
"cigarettes daily",
"past 30 years",
"current medications include lisinopril",
"niacin",
"brother died",
"colonic adenocarcinoma",
"father died of small cell lung cancer",
"5 ft 6",
"tall",
"83 kg",
"BMI",
"29 kg/m2",
"vital signs",
"normal limits",
"Physical examination shows",
"abnormalities",
"Serum lipid studies show",
"Total cholesterol",
"mg/dL HDL",
"Triglycerides",
"following",
"most appropriate next step",
"management"
] | 00000000000000000089 |
ํดํ์ฑ ๊ด์ ์ผ์ผ๋ก ์ค๋ฅธ์ชฝ ๋ฌด๋ฆ ๊ด์ ์ฑํ์ ์ ๋ฐ์ ์ง 5์ผ์งธ ๋๋ 68์ธ ๋จ์๊ฐ ๋ฌผ๋ฆฌ ์น๋ฃ์ ์ฐธ์ฌํ ์ ์์ ์ ๋๋ก ์ค๋ฅธ์ชฝ ๋ฌด๋ฆ์ ์ฌํ ํต์ฆ์ ํธ์ํ๊ณ ์์ต๋๋ค. ์์ ํ 3์ผ์งธ ๋๋ ์ฑ์ ๊ต์ฒดํ์ ๋ ์์ ๋ถ์๋ ์จ์ ํด ๋ณด์๊ณ ์ฝ๊ฐ ๋ถ์ด ์์์ผ๋ฉฐ ๋ง์ ๋ถ๋น๋ฌผ์ด ์์์ต๋๋ค. ํ์๋ ๋น๋จ๋ณ, ๊ณ ์งํ์ฆ, ๊ณ ํ์์ ๋ณ๋ ฅ์ ๊ฐ์ง๊ณ ์์ต๋๋ค. ํ์ฌ ๋ณต์ฉ ์ค์ธ ์ฝ๋ฌผ์ ๋ฉํธํฌ๋ฅด๋ฏผ, ์๋ ๋ผํ๋ฆด, ์ฌ๋ฐ์คํํด์
๋๋ค. ํ์์ ์ฒด์จ์ 37.3ยฐC(99.1ยฐF), ๋งฅ๋ฐ์ ๋ถ๋น 94ํ, ํ์์ 130/88 mm Hg์
๋๋ค. ์ค๋ฅธ์ชฝ ๋ฌด๋ฆ์ ๋ถ์ด ์๊ณ , ๋ฐ์ ๋์ด ์์ผ๋ฉฐ, ์ด์ง ์ ์ํต์ด ์์ต๋๋ค. ๊ด์ ์ด๋ ์ ํต์ฆ์ด ์์ต๋๋ค. ๋ด์ธก ์ฌ๊ฐ๊ณจ ์ ํผ๋ถ ์ ๊ฐ ๋ถ์๋ ๊ทผ์๋ถ์ ์์๋ถ์์ ๊ฒ์ผ๋ก ์ด๋ ค ๋ณด์ด๋ฉฐ ํฉ๋ก์ ๋ถ๋น๋ฌผ์ด ์์ต๋๋ค. ์ ๊ฐ ๋ถ์ ์์ชฝ ํผ๋ถ๊ฐ ๊ฒ๊ฒ ๋ณ์๋์ด ์์ต๋๋ค. ๋ค์ ์ค ์ด ํ์ ๊ด๋ฆฌ์ ๋ค์ ๋จ๊ณ๋ก ๊ฐ์ฅ ์ ์ ํ ๊ฒ์ ๋ฌด์์
๋๊น? | Surgical debridement | {
"A": "์ธ๊ณผ์ ๋ณ์ฐ ์ ์ ์ ",
"B": "๋ํ์ค๋ฆฐ ์น๋ฃ",
"C": "๋ณด์ฒ ๋ฌผ ์ ๊ฑฐ",
"D": "๋ฐฉ๋ถ ๋๋ ์ฑ"
} | step2&3 | A | [
"Five days",
"right knee arthroplasty",
"osteoarthritis",
"68 year old man",
"severe pain in",
"right knee preventing",
"participating",
"physical therapy",
"third postoperative day",
"dressing",
"changed",
"surgical wound appeared to",
"intact",
"slightly swollen",
"clear secretion",
"history",
"diabetes",
"hyperlipidemia",
"hypertension",
"Current medications include metformin",
"enalapril",
"simvastatin",
"temperature",
"3C",
"99",
"pulse",
"min",
"blood pressure",
"88 mm Hg",
"right knee",
"swollen",
"erythematous",
"tender",
"palpation",
"pain on movement",
"joint",
"medial parapatellar skin incision appears",
"opened",
"proximal",
"distal part",
"yellow-green discharge",
"skin",
"sides",
"incision",
"following",
"next best step",
"management",
"patient"
] | 00000000000000000090 |
53์ธ ์ฌ์ฑ์ด 2์์ ๋ฐ์ด, ์คํ, ๋ํต ๋ฐ ๋ง๋ฅธ ๊ธฐ์นจ์ด ํ๋ฃจ ๋์ ์ง์๋์๋ค๋ ์ด์ ๋ก ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ๊ทธ๋
๋ ๋ํ ๊ถํ๊ฐ๊ณผ ์ ์ ๊ทผ์กํต์ ํธ์ํฉ๋๋ค. ๊ทธ๋
๋ ์ง์ญ ๊ณ ๋ฑํ๊ต์์ ๊ต์ฌ๋ก ์ผํ๊ณ ์์ผ๋ฉฐ, ์ต๊ทผ์ ์ธํ๋ฃจ์์๊ฐ ๋ฐ์ํ์ต๋๋ค. ๊ทธ๋
๋ ๊ฐํ์ ์ธ ์ฒ์ ๋ณ๋ ฅ์ด ์์ผ๋ฉฐ, ํ์ํ ๋๋ง๋ค albuterol์ ๋ณต์ฉํฉ๋๋ค. ๊ทธ๋
๋ ๊ฐ์์ ์ ๊ณต๋ ์ธํ๋ฃจ์์ ๋ฐฑ์ ์ ๊ฑฐ์ ํ๋๋ฐ, ๊ทธ ์ด์ ๋ ๊ทธ๋
์ ์ฌ๋์์ด ์น๊ตฌ๊ฐ ๋ฐฑ์ ์ ์ ์ข
๋ฐ์ ํ ๋
๊ฐ๊ณผ ์ ์ฌํ ์ง๋ณ์ด ๋ฐ์ํ๋ค๊ณ ๋งํ๊ธฐ ๋๋ฌธ์
๋๋ค. ๊ทธ๋
๋ ๋ณ์ ๊ฑธ๋ฆด ๊ฐ๋ฅ์ฑ์ ๋ํด ๊ฑฑ์ ํ๊ณ ์์ผ๋ฉฐ ๊ฒฐ๊ทผํ ์ฌ์ ๊ฐ ์์ต๋๋ค. ๊ทธ๋
์ ์ฒด์จ์ 37.9ยฐC (100.3ยฐF)์ด๊ณ , ์ฌ๋ฐ์๋ 58ํ/๋ถ์ด๋ฉฐ, ํธํก์๋ 12ํ/๋ถ์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์๋ ํน์ด ์๊ฒฌ์ด ์์ต๋๋ค. ๊ทธ๋
์ ํค๋ชจ๊ธ๋ก๋น ๋๋๋ 14.5 g/dL์ด๊ณ , ๋ฐฑํ๊ตฌ ์๋ 9,400/mm3์ด๋ฉฐ, ํ์ํ ์๋ 280,000/mm3์
๋๋ค. ์งํต์ ์ธ์, ๋ค์ ์ค ๊ด๋ฆฌ์์ ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Oseltamivir | {
"A": "Supportive therapy only",
"B": "Amantadine",
"C": "Inactivated influenza vaccine",
"D": "Oseltamivir"
} | step2&3 | D | [
"year old woman",
"physician",
"February",
"1-day history",
"fever",
"chills",
"headache",
"dry cough",
"reports malaise",
"generalized muscle aches",
"works",
"teacher",
"local high school",
"recently",
"outbreak",
"influenza",
"history of intermittent asthma",
"takes albuterol as needed",
"influenza vaccine offered",
"fall",
"sister",
"friend",
"flulike illness",
"receiving",
"vaccine",
"worried",
"possibly",
"ill",
"to miss work",
"temperature",
"100",
"heart rate",
"58 min",
"respirations",
"min",
"Physical examination",
"unremarkable",
"hemoglobin concentration",
"g/dL",
"leukocyte count",
"400 mm3",
"platelet count",
"mm3",
"analgesia",
"following",
"most appropriate next step",
"management"
] | 00000000000000000091 |
์ ๋ก ์๋งน์ X-linked recessive disorder์ด๋ฉฐ, ํน์ ์ธ๊ตฌ ์ง๋จ์์ ๋จ์ฑ์ ๋ฐ๋ณ๋ฅ ์ 1/200์
๋๋ค. ํํํ์ ์ผ๋ก ์ ์์ธ ๋จ์ฑ๊ณผ ์ฌ์ฑ์ด ์ ๋ก ์๋งน์ธ ์๋
๋ฅผ ๊ฐ์ง ํ๋ฅ ์ ์ผ๋ง์
๋๊น? | 1/400 | {
"A": "1/200",
"B": "199/200",
"C": "1/100",
"D": "1/400"
} | step1 | D | [
"Red-green color blindness",
"X-linked recessive disorder",
"incidence",
"200",
"males",
"certain population",
"probability",
"normal male",
"female",
"child",
"red-green color blindness"
] | 00000000000000000092 |
45์ธ ๋จ์ฑ์ด ๊ธ์ฑ ํธํก ๋ถ์ ์ผ๋ก ์๊ธ์ค์์ ์คํ์์ค๋ก ์ด์ก๋์์ต๋๋ค. ๊ทธ๋ ์ง๋ 24์๊ฐ ๋์ ์ ์ง์ ์ธ ํธํก ๊ณค๋์ด ๋ฐ์ํ ํ ๋ณ์์ผ๋ก ์ด์ก๋์์ต๋๋ค. ๊ทธ์ ๋ณ๋ ฅ์ ์ฅ๊ธฐ๊ฐ ์ง์์ ์ธ ์ค์ฆ ์ฒ์, ๊ณ ํ์, ์ฌ๋ฌ ์ฐจ๋ก์ ์ง์ญ ์ฌํ ๋ฐ ๋ณ์ ํ๋ ํ๋ ด์ผ๋ก ์ค์ํฉ๋๋ค. ๊ทธ์ ์ฝ๋ฌผ์๋ amlodipine, lisinopril, ํก์
fluticasone, salmeterol ๋ฐ ๊ฒฝ๊ตฌ prednisone์ด ํฌํจ๋ฉ๋๋ค. ๊ทธ๋ ํ์ ๋นํก์ฐ์์ด๋ฉฐ ์ฃผ๋ง์ ๊ฐ๋ ์ ์ ๋ง์ญ๋๋ค. ๊ทธ๋ ์์
์์์ผ๋ก ์ผํ๋ฉฐ ํ ๋ฌ ์ ์ ํ์์ด์ ๊ฐ์์ต๋๋ค. ์๊ธ์ค์์ ๊ทธ๋ ๊ด๋ฒ์ ํญ์์ ์ ๊ธฐ๊ด์ง ํ์ฅ์ ๋ฅผ ํฌ์ฌ๋ฐ๊ธฐ ์์ํ์ต๋๋ค. ๊ทธ์ ํธํก ๋ถ์ ์ ์ ์ฐจ ์
ํ๋๊ณ ์
์ 2์ผ์งธ์ ๊ธฐ๊ณ ํ๊ธฐ ์ฅ์น ์ง์์ด ํ์ํฉ๋๋ค. ํ๋ถ X-๋ ์ด๋ ์์ชฝ ํ์ฝ์ ์ฌ๋ฌ ๊ฐ์ ๊ฒฐ์ ์ ๋ณด์ฌ์ค๋๋ค. ์ ์ฐ์ฑ ๊ธฐ๊ด์ง๊ฒฝ ๊ฒ์ฌ๋ฅผ ์ํํ๊ณ ์ค๋ฅธ์ชฝ ํ์ฝ ์ค๊ฐ ๋ถ์ ์์ ์ฑ์ทจํ ๊ธฐ๊ด์ง ํํฌ ์ธ์ฒ์ก ์ํ์์ ํธ์ค๊ตฌ๊ฐ ๋ํ๋๊ณ ๊ณฐํก์ด ์ ์ ์์ Aspergillus fumigatus๊ฐ ๋ํ๋ฉ๋๋ค. ๋น๋์ค ๋ณด์กฐ ํ๊ฐ๊ฒฝ ๊ฒ์ฌ๋ฅผ ์ํํ๊ณ ์ค๋ฅธ์ชฝ ํ์ฝ์์ ์๊ฒ์ ์ฑ์ทจํ ๊ฒฐ๊ณผ, ๋ง๋จ ์ธ๊ธฐ๊ด์ง๊ฐ ์ ์ก, ์ผ์ฆ ์ธํฌ ๋ฐ ๊ณฐํก์ด ํ๊ด ์นจ์
์ผ๋ก ๋งํ์๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ๋ค์ ์ค ์๊ฒ ๊ฒฐ๊ณผ์ ๊ฐ์ฅ ํฐ ์ํฅ์ ๋ฏธ์น๋ ๋ฉ์ปค๋์ฆ์ ๋ฌด์์
๋๊น? | Defects in the immune response | {
"A": "Defects in the immune response",
"B": "Aspergillus fumigatus suppresses the production of IgA",
"C": "Aspergillus fumigatus suppresses the production of IgM",
"D": "Suppression of the innate immune system by Aspergillus fumigatus"
} | step1 | A | [
"year old man",
"transferred",
"intensive care unit",
"emergency department",
"acute respiratory failure",
"rushed",
"hospital",
"progressive respiratory distress",
"24 hours",
"medical history",
"significant",
"long standing severe persistent asthma",
"hypertension",
"several bouts",
"community",
"hospital-acquired pneumonia",
"medications include amlodipine",
"lisinopril",
"inhaled fluticasone",
"salmeterol",
"oral prednisone",
"lifelong non-smoker",
"drinks alcohol occasionally",
"weekends",
"works",
"sales executive",
"to Hawaii",
"month",
"emergency department",
"started",
"broad spectrum antibiotics",
"bronchodilators",
"respiratory failure",
"worsens",
"day 2",
"admission",
"mechanical ventilator support",
"Chest X-ray shows multiple nodules",
"lower lobes",
"Flexible bronchoscopy",
"performed",
"bronchoalveolar lavage sample",
"medial segment",
"right lower lobe shows neutrophils",
"fungal preparation shows Aspergillus fumigatus",
"video-assisted thoracoscopy",
"performed",
"biopsy",
"right lower lobe",
"taken",
"shows plugging",
"terminal bronchioles",
"mucus",
"inflammatory cells",
"fungal vascular invasion",
"following",
"most likely mechanism responsible",
"biopsy findings"
] | 00000000000000000093 |
70์ธ ๋จ์ฑ์ด 4๊ฐ์๊ฐ์ ์๋ณต๋ถ ํต์ฆ, ๋ฉ์ค๊บผ์, ๊ทธ๋ฆฌ๊ณ ์ ์ฝ๊ฐ์ผ๋ก ์ธํด ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ๊ทธ๋ 50๋
๋์ ๋งค์ผ ๋ด๋ฐฐ ํ ๊ฐ์ ํผ์ ๊ณ ๋งค์ผ ์ ํ ์์ ๋ง์ญ๋๋ค. ๊ทธ๋ ์์ฒํด ๋ณด์
๋๋ค. ๊ทธ๋ ํค 175 cm (5 ft 9 in), ์ฒด์ค 47 kg (103 lb)์ด๋ฉฐ, BMI๋ 15 kg/m2์
๋๋ค. ๊ทธ๋ ์์ ์ง๋จ์ ๋ฐ์์ต๋๋ค. ๋ค์ ์ฌ์ดํ ์นด์ธ ์ค ์ด๋ค ๊ฒ์ด ์ด ํ์์ ๊ฒ์ฌ ๊ฒฐ๊ณผ์ ๋ํ ๊ฐ์ฅ ์ง์ ์ ์ธ ์์ธ์ผ ๊ฐ๋ฅ์ฑ์ด ๋์ต๋๊น? | IL-6 | {
"A": "TGF-ฮฒ",
"B": "IL-6",
"C": "IL-2",
"D": "TNF-ฮฒ"
} | step1 | B | [
"70 year old man",
"physician",
"4 month history",
"epigastric pain",
"nausea",
"weakness",
"smoked one pack",
"cigarettes daily",
"50 years",
"drinks one alcoholic beverage daily",
"appears emaciated",
"5 ft 9",
"tall",
"kg",
"BMI",
"kg/m2",
"diagnosed",
"gastric cancer",
"following cytokines",
"most likely direct cause of",
"patients examination findings"
] | 00000000000000000094 |
40์ธ ์ฌ์ฑ ํ์๊ฐ 1์ฃผ์ผ๊ฐ์ ํผ๋ก, ์ง์ ์๋ณ, ๋ค๋ฆฌ์ ๋ฌด๊ฑฐ์ด ๋๋์ ํธ์ํ๋ฉฐ ๋ด์ํ๋ค. 2์ฃผ ์ , ๊ทธ๋
๋ ๋ธ๋ผ์ง๋ก ํด๊ฐ๋ฅผ ๋ค๋
์์ผ๋ฉฐ, ๊ทธ๊ณณ์์ ๋ฆฌ์ฐ๋ฐ์๋ค์ด๋ฃจ ๋์๋ฅผ ๋๋ณด๋ก ํํํ๋ฉฐ ๋๋ถ๋ถ์ ์๊ฐ์ ๋ณด๋๋ค. ๋ํ ํด๊ฐ ๋์ 3 kg (7 lb) ์ฒด์ค์ด ์ฆ๊ฐํ๋ค. ๊ทธ๋
๋ ์ ์ ์ฑ ํ๋ฐ์ฑ ๋ฃจํธ์ค๋ฅผ ์๊ณ ์๋ค. ๊ทธ๋
๊ฐ ๋ณต์ฉํ๋ ์ ์ผํ ์ฝ๋ฌผ์ ํ์ด๋๋ก์ํด๋ก๋กํธ์ด๋ค. ์ฒด์จ์ 37.5ยฐC (99.5ยฐF), ๋งฅ๋ฐ์ 78ํ/๋ถ, ํ์์ 162/98 mm Hg์ด๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ์์ธก 2+ ์ ๊ฒฝ๊ณจ ๋ถ์ข
์ด ๋ํ๋ฌ๋ค. ์๋ณ ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ๋ค:
ํ์ก 3+
๋จ๋ฐฑ์ง 1+
๋ณํ๋ ํน์ง์ ๊ฐ์ง RBC 6-8/hpf
RBC ์์ฃผ ๋ค์
WBC 8/hpf
WBC ์์ฃผ ํฌ์
์ธ๊ท ์์ฑ
๋ค์ ์ค ์ด ํ์์ ๋ค๋ฆฌ ์๊ฒฌ์ ๊ฐ์ฅ ์ ๋ ฅํ ์์ธ์ ๋ฌด์์ธ๊ฐ?" | Salt retention | {
"A": "์ ๋งฅ ๋ถ์ ",
"B": "๋ฆผํ๊ด ํ์",
"C": "์ ์ฑ ๋จ๋ฐฑ์ง ์์ค",
"D": "์ผ๋ถ ์ ์ฒด"
} | step2&3 | D | [
"40 year old woman",
"physician",
"1-week history",
"fatigue",
"dark urine",
"feeling of heaviness",
"legs",
"Two weeks",
"returned",
"vacation",
"Brazil",
"spent most",
"days",
"city",
"Rio de",
"foot",
"gained 3 kg",
"vacation",
"systemic lupus erythematosus",
"only medication",
"hydroxychloroquine",
"temperature",
"99",
"pulse",
"min",
"blood pressure",
"98 mm Hg",
"Physical examination shows 2",
"edema",
"Urinalysis shows",
"Blood",
"Protein 1",
"RBC 68 hpf",
"dysmorphic features",
"casts numerous WBC",
"hpf",
"casts rare Bacteria negative",
"following",
"most likely cause",
"patient",
"eg indings?"
] | 00000000000000000095 |
์งํ์ฑ ๋ฐฉ๊ด์์ ์๊ณ ์๋ 67์ธ ์ฌ์ฑ์ด ์ถ์ ๊ฒ์ฌ๋ฅผ ์ํด ์์ฌ์๊ฒ ๋ด์ํ์ต๋๋ค. ๊ทธ๋
๋ ํ์ฌ DNA ๊ฐ๋ฅ ์ฌ์ด์ ๊ต์ฐจ ๊ฒฐํฉ์ ํ์ฑํ๋ ์ ์ ๋ก ํํ ์๋ฒ์ ๋ฐ๊ณ ์์ต๋๋ค. ํ์ฒญ ๊ฒ์ฌ ๊ฒฐ๊ณผ ํฌ๋ ์ํฐ๋ ๋๋๋ 2.1 mg/dL, ํ์ค ์์ ์ง์ ๋๋๋ 30 mg/dL๋ก ๋ํ๋ฌ์ต๋๋ค. ์ฒญ๊ฒฐํ๊ฒ ์ฑ์ทจํ ์ค๊ฐ๋จ ๊ฒ์ฒด์ ๋ํ ์๋ณ ๊ฒ์ฌ์ง์์๋ ๋จ๋ฐฑ์ง 2+, ํฌ๋๋น 1+๊ฐ ๋ํ๋ฌ์ต๋๋ค. ํํ ์๋ฒ ์์ ์ , ๊ทธ๋
์ ์คํ์ค ์์น๋ ์ฐธ๊ณ ๋ฒ์ ๋ด์ ์์์ต๋๋ค. ์๋ถ ๊ณต๊ธ ์ธ์๋ ๋ค์ ์ค ์ด๋ค ๊ฒ์ ํฌ์ฌํ๋ ๊ฒ์ด ์ด ํ์์ ํ์ฌ ์ํ๋ฅผ ์๋ฐฉํ๋ ๋ฐ ๊ฐ์ฅ ํจ๊ณผ์ ์ด์์๊น์? | Amifostine | {
"A": "Mesna",
"B": "Amifostine",
"C": "Rasburicase",
"D": "Leucovorin"
} | step1 | B | [
"67 year old woman",
"advanced bladder",
"physician",
"follow-up examination",
"currently",
"chemotherapy",
"agent",
"forms cross-links",
"DNA strands",
"Serum studies show",
"creatinine concentration",
"2",
"mg dL",
"blood urea nitrogen concentration",
"mg/dL",
"Urine",
"clean-catch",
"specimen shows 2",
"protein",
"1",
"glucose",
"Prior to initiation",
"chemotherapy",
"laboratory values",
"reference range",
"hydration",
"administration",
"following",
"most likely",
"prevented",
"patient's current condition"
] | 00000000000000000096 |
57์ธ์ ํ๊ฒฝ๊ธฐ ์ดํ ์ฌ์ฑ์ด ์ง๋ ํ ๋ฌ ๋์ ๊ฐํ์ ์ธ ํ์ฑ ์ฑ๊ต ํ ์ง ๋ถ๋น๋ฌผ๋ก ์ธํด ์์ฌ๋ฅผ ์ฐพ์์ต๋๋ค. ๊ทธ๋
๋ ์ฑ๊ต ์ ํต์ฆ์ ๋๋ผ์ง ์์ต๋๋ค. 11๋
์ , ๊ทธ๋
๋ ์ ๊ธฐ์ ์ธ Pap smear์์ LSIL์ ๋ณด์๊ณ ๊ณ ์ํ๊ตฐ HPV ๊ท ์ฃผ ๊ฒ์ฌ์์ ์์ฑ ํ์ ์ ๋ฐ์์ต๋๋ค. Colposcopy๋ CIN 1์ ๋ณด์ฌ์ฃผ์์ต๋๋ค. ๊ทธ ์ดํ๋ก ๊ทธ๋
๋ ์ถ์ Pap smear๋ฅผ ์ํด ๋์์ค์ง ์์์ต๋๋ค. ๊ทธ๋
๋ ๋จํธ๊ณผ๋ง ์ฑ์ ์ผ๋ก ํ๋ํ๋ฉฐ ์ฝ๋์ ์ฌ์ฉํ์ง ์์ต๋๋ค. ๊ทธ๋
๋ ์ง๋ 25๋
๋์ ํ๋ฃจ์ ๋ด๋ฐฐ ๋ฐ ๊ฐ์ ํผ์ ๊ณ ์ ์ ๋ง์์ง ์์ต๋๋ค. Speculum ๊ฒ์ฌ์์ 1.4cm ํฌ๊ธฐ์ ํ๋ฐ์ฑ ์ธ์์ฑ ์ข
๊ดด๊ฐ ์ง ์๋ถ 1/3์ ํ๋ฒฝ์์ ๊ถค์๊ณผ ํจ๊ป ๊ด์ฐฐ๋ฉ๋๋ค. ๋ค์ ์ค ์ด ์ข
๊ดด์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ์๋ ์กฐ์ง๋ณ๋ฆฌํ์ ์๊ฒฌ์ ๋ฌด์์
๋๊น? | Squamous cell carcinoma | {
"A": "Squamous cell carcinoma",
"B": "Basal cell carcinoma",
"C": "Melanoma",
"D": "Sarcoma botryoides"
} | step2&3 | A | [
"57 year old post-menopausal woman",
"physician",
"of intermittent",
"bloody post-coital vaginal discharge",
"past month",
"not",
"pain with intercourse",
"Eleven years",
"LSIL",
"routine Pap smear",
"testing",
"high-risk HPV strains",
"positive",
"Colposcopy showed CIN 1",
"not returned",
"follow-up Pap smears",
"then",
"sexually active",
"husband only",
"not use condoms",
"smoked half",
"pack",
"cigarettes",
"day",
"past",
"years",
"not drink alcohol",
"speculum exam",
"erythematous exophytic mass",
"ulceration",
"noted",
"posterior wall of",
"upper third of",
"vagina",
"following",
"most probable histopathology",
"mass"
] | 00000000000000000097 |
์๋ก์ด ๋ง๋ผ๋ฆฌ์ ์๋ฐฉ ์ฝ๋ฌผ์ ๋ณต์ฉํ ์ง 3์ผ ํ, 19์ธ ๋ํ์์ด ์ด๋์ด ์์ ์๋ณ๊ณผ ํผ๋ก๊ฐ์ ํธ์ํ๋ฉฐ ์์ฌ๋ฅผ ์ฐพ์๋ค. ๊ทธ๋ ๋ฐ์ด, ๋ฐฐ๋จ ๊ณค๋, ๋๋ ๋ณตํต์ ์์๋ค. ์ฌ๊ฐํ ์ง๋ณ์ ๋ณ๋ ฅ๋ ์๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ๊ณต๋ง ํฉ๋ฌ์ด ๋ํ๋ฌ๋ค. ์คํ์ค ๊ฒ์ฌ ๊ฒฐ๊ณผ ํ์์๋ 9.7 g/dL, ํ์ฒญ ์ ์ฐ ํ์์ ํจ์๋ 234 U/L๋ก ๋ํ๋ฌ๋ค. ๋ง์ด ํ์ก ๋๋ง ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋ฌผ๋ฆฐ ์๊ตญ ๋ชจ์์ ๋ถ๊ท์น์ฑ์ ๊ฐ์ง ๋ณํ์ ํ๊ตฌ๊ฐ ๊ด์ฐฐ๋์๋ค. ํ์๊ฐ ๋ณต์ฉํ์ ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ๋์ ์ฝ๋ฌผ์ ๋ค์ ์ค ๋ฌด์์ธ๊ฐ? | Primaquine | {
"A": "Primaquine",
"B": "Dapsone",
"C": "Ivermectin",
"D": "Doxycycline"
} | step1 | A | [
"Three days",
"starting",
"new",
"malaria",
"year old college student",
"physician",
"dark-colored urine",
"fatigue",
"not",
"fever",
"dysuria",
"abdominal pain",
"history",
"serious illness",
"Physical examination shows scleral icterus",
"Laboratory studies show a hemoglobin",
"g/dL",
"serum lactate dehydrogenase",
"234 U L",
"Peripheral blood smear shows poikilocytes",
"bite shaped irregularities",
"following drugs",
"patient",
"likely",
"taking"
] | 00000000000000000098 |
๊ทํ๋ ์๋ก์ด AIDS ์ ๋ณ ๊ฒ์ฌ์ ํจ๊ณผ๋ฅผ ์กฐ์ฌํ๊ธฐ ์ํด ๊ทํ์ ์๋ฃ ์ผํฐ์์ ์ํ๋ ์ฐ๊ตฌ์ ์์ ๋ฐ์ดํฐ๋ฅผ ๊ฒํ ํ๊ณ ์์ต๋๋ค. ์ด ์ฐ๊ตฌ์๋ AIDS๊ฐ ํ์ง๋ ํ์ 250๋ช
์ด ๋ฑ๋ก๋์์ผ๋ฉฐ, ์ด ํ์ ์ค 240๋ช
์ด ์์ฑ ์ ๋ณ ๊ฒ์ฌ๋ฅผ ๋ณด์์ต๋๋ค. ์ฐ๊ตฌ์ ๋์กฐ๊ตฐ์๋ AIDS๊ฐ ์๋ ํ์ 250๋ช
์ด ๋ฑ๋ก๋์์ผ๋ฉฐ, ์ด ํ์ ์ค 5๋ช
๋ง์ด ์๋ก์ด ์ ๋ณ ๊ฒ์ฌ์์ ์์ฑ ๋ฐ์์ ๋ณด์์ต๋๋ค. ์ด ์๋ก์ด ๊ฒ์ฌ์ NPV๋ ๋ฌด์์
๋๊น? | 245 / (245 + 10) | {
"A": "245 / (245 + 10)",
"B": "245 / (245 + 5)",
"C": "240 / (240 + 5)",
"D": "240 / (240 + 15)"
} | step2&3 | A | [
"reviewing raw data",
"research study performed",
"medical center examining",
"effectiveness",
"novel AIDS screening examination",
"study enrolled",
"patients",
"confirmed AIDS",
"patients",
"positive screening examination",
"control arm",
"study enrolled",
"patients",
"not",
"AIDS",
"only",
"patients tested positive",
"novel screening examination",
"NPV",
"novel test"
] | 00000000000000000099 |
P1G0 ๋น๋จ๋ณ ์ฌ์ฑ์ ์์ 30์ฃผ์ ์ถ์ฐํ ์ํ์ด ์์ต๋๋ค. ๊ทธ๋
์ ์ฐ๋ถ์ธ๊ณผ ์์ฌ๋ ์๊ธฐ๊ฐ ํ์ด๋ ํ ์ฌ๊ฐํ ํ ํธํก ๊ณค๋์ ๊ฒช์ ์ ์๋ค๋ ์ํ์ด ์๋ค๊ณ ์ค๋ช
ํฉ๋๋ค. ๊ทธ๋ฌ๋ ์์ฌ๋ ์ด๋ฅผ ์๋ฐฉํ๊ธฐ ์ํด ์ฐ๋ชจ์๊ฒ ์ฝ๋ฌผ์ ํฌ์ฌํ ๊ฒ์ด๋ผ๊ณ ๋งํฉ๋๋ค. ์ด ์ฝ๋ฌผ์ ์ด๋ค ์์ฉ์ผ๋ก ๋ฏธ์์์ ํธํก ๊ณค๋์ ์๋ฐฉํ ๊น์? | Increasing the secretory product of type II alveolar cells | {
"A": "์ ์์ ๋ฉด์ญ ์ฒด๊ณ ์ต์ ",
"B": "์ IIํ ํํฌ ์ธํฌ์ ๋ถ๋น๋ฌผ ์ฆ๊ฐ",
"C": "๋ฏธ์ฑ์ํ ํ์ ๊ฐ์ผ ์๋ฐฉ",
"D": "์ IIํ ํํฌ ์ธํฌ์ ๋ถ๋น๋ฌผ ๊ฐ์"
} | step1 | B | [
"diabetic woman",
"at risk",
"delivering",
"30 weeks gestation",
"obstetrician counsels",
"risk",
"baby",
"significant pulmonary distress",
"born",
"states",
"administer",
"drug",
"mother to help prevent",
"occurring",
"action",
"drug prevent respiratory distress",
"premature infant"
] | 00000000000000000100 |
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