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Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Problem:Question: Are serum levels of activin A and inhibin A related to the increased susceptibility to pre-eclampsia in type I diabetic pregnancies?
Answer: Serum concentrations of activin A and inhibin A could not predict preeclampsia in type I diabetes.
Solution: | no | task846_pubmedqa_classification |
|
You will be given a definition of a task first, then some input of the task.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does sevoflurane alter norepinephrine-induced intracellular Ca² ( + ) changes in the diabetic rat aorta?
Answer: Sevoflurane at clinically relevant concentrations inhibited the NE-induced increase in [Ca²(+)](i) in the aortic smooth muscle from normal rats but not in that from type 2 DM rats. Thus, a Ca²(+)- signalling pathway resistant to sevoflurane appears to exist in the type 2 DM rat aorta.
Output: | no | task846_pubmedqa_classification |
|
Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
See one example below:
Problem: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Problem: Question: Is osteoprotegerin associated with subclinical left ventricular systolic dysfunction in diabetic hypertensive patients : a speckle tracking study?
Answer: Plasma OPG values could predict subclinical LV systolic dysfunction in diabetic hypertensive patients.
Solution: | yes | task846_pubmedqa_classification |
|
TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Is race a predictor of prostate cancer detection on repeat prostate biopsy?
Answer: Race is not a predictor of prostate cancer detection in men undergoing repeat prostate biopsies. With the exception of HGPIN, all other clinical parameters were similar between black and white men. Serum PSA, PSA velocity, HGPIN and ASAP were found to be significant predictors of subsequent prostate cancer detection.
SOLUTION: no
PROBLEM: Question: Does presence of the full-length KIR2DS4 gene reduce the chance of rheumatoid arthritis patients to respond to methotrexate treatment?
Answer: Our results suggest that the response of RA patients with medium ESR values to MTX treatment may be dependent on the full-length KIR2DS4 gene.
SOLUTION: yes
PROBLEM: Question: Do mesenchymal stem cells treated with rat pancreatic extract secrete cytokines that improve the glycometabolism of diabetic rats?
Answer: RPE enhanced the secretion of cytokines by MSCs. MSCs in the pancreatic microenvironment may exert indirect salutary effects via paracrine mediators on injured pancreatic cells in an STZ-induced diabetic animal model. The secreted factors may exert their therapeutic benefits by preventing apoptosis of pancreatic beta cells.
SOLUTION: | yes
| task846_pubmedqa_classification |
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Given the task definition, example input & output, solve the new input case.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Output: yes
The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
New input case for you: Question: Do hLA-DQB1 subtypes predict diabetic retinopathy in patients with type I diabetes mellitus?
Answer: Some haplotypes seem to predispose diabetic patients to diabetic retinopathy. HLA typing may be beneficial for predicting the prognosis of diabetic retinopathy in younger diabetic patients.
Output: | yes | task846_pubmedqa_classification |
|
Given the task definition and input, reply with output. Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does a diabetes scorecard improve HbA ( 1c ) , blood pressure , lipids , aspirin usage , exercise and diabetes knowledge over 9 months : a randomized controlled trial?
Answer: A diabetes scorecard did not improve glycaemic control, blood pressure control, LDL cholesterol, aspirin usage, exercise or diabetic knowledge in an urban population with uncontrolled Type 2 diabetes.
| no | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[Q]: Question: Is arthrogenic muscle inhibition present in the limb contralateral to a simulated knee joint effusion?
Answer: Knee joint effusion results in ipsilateral but not contralateral impairment of quadriceps function. Rehabilitation protocols after knee joint injury should focus on ipsilateral neuromuscular and mechanical alterations that occur as the result of joint damage.
[A]: no
[Q]: Question: Does a null mutation in ANGPTL8 associate with either plasma glucose or type 2 diabetes in humans?
Answer: Disruption of ANGPTL8 function in humans does not seem to have a large effect on measures of glucose tolerance.
[A]: no
[Q]: Question: Does a diabetes scorecard improve HbA ( 1c ) , blood pressure , lipids , aspirin usage , exercise and diabetes knowledge over 9 months : a randomized controlled trial?
Answer: A diabetes scorecard did not improve glycaemic control, blood pressure control, LDL cholesterol, aspirin usage, exercise or diabetic knowledge in an urban population with uncontrolled Type 2 diabetes.
[A]: | no
| task846_pubmedqa_classification |
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Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Problem:Question: Does sulforaphane prevent Neuronal Apoptosis and Memory Impairment in Diabetic Rats?
Answer: SFN could prevent the memory impairment and apoptosis of hippocampal neurons in diabetic rat. The possible mechanism was related to the regulation of neurotropic factors and Akt/GSK3β pathway.
Solution: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[Q]: Question: Are fatty acid-amino acid conjugates essential for systemic activation of salicylic acid-induced protein kinase and accumulation of jasmonic acid in Nicotiana attenuata?
Answer: Our results reveal that N. attenuata specifically recognizes herbivore-derived FACs in damaged leaves and rapidly send out a long-distance signal to phylotactically connected leaves to activate MAPK and JA signaling, and we propose that FACs that penetrated into wounds rapidly induce the production of another long-distance signal(s) which travels to all systemic leaves and activates TPI defense.
[A]: yes
[Q]: Question: Does remote ischemic preconditioning affect the incidence of acute kidney injury after elective abdominal aortic aneurysm repair?
Answer: RIPC did not reduce the risk of postoperative renal failure or myocardial injury in patients undergoing open AAA repair. The authors' results do not support the introduction of this technique to routine clinical practice.
[A]: no
[Q]: Question: Does inhibition of mitochondrial permeability transition pore restore the cardioprotection by postconditioning in diabetic hearts?
Answer: The loss of cardioprotection by IPostC in diabetic state can be overcome by increasing the potency of protective IPostC through its co-application with mPTP inhibition.
[A]: | yes
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example Input: Question: Is neutrophil-lymphocyte ratio a reliable predictive marker for early-stage diabetic nephropathy?
Answer: Increased NLR was significantly associated with DN, and high NLR values may be a reliable predictive marker of early-stage DN.
Example Output: yes
Example Input: Question: Does metoclopramide influence the frequency of propofol-induced spontaneous movements?
Answer: Metoclopramide does not affect the frequency of propofol-induced movements, but propofol and fentanyl doses influence the frequency of movements during propofol induction.
Example Output: no
Example Input: Question: Does comparative study of the failure rates among 3 implantable defibrillator lead?
Answer: This study demonstrates a higher failure rate of Linox S/SD high-voltage leads compared to contemporary leads. Although the mechanism of lead failure is unclear, the majority presents with abnormal electrical parameters. Comprehensive monitoring of Linox S/SD high-voltage leads includes remote monitoring to facilitate early detection of lead failure.
Example Output: | yes
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Does ginsenoside Rg3 improve erectile function in streptozotocin-induced diabetic rats?
Answer: Oral gavage with Rg3 appears to both prevent degeneration of neurons in the dorsal nerves and exert an antioxidant effect in the corpus cavernosum of rats.
A: yes
****
Q: Question: Are filaggrin loss-of-function mutations a predisposing factor for atopic dermatitis in an Ishigaki Island under subtropical climate?
Answer: The FLG loss-of-function mutation frequency was not significantly different between the AD and non-AD groups in a cohort of children from Ishigaki Island, which has a subtropical climate, suggesting that FLG loss-of-function mutations are not always a predisposing factor for AD prevalence.
A: no
****
Q: Question: Does analysis of pulmonary function test result in a health check-up population?
Answer: Health check-up is an important approach for screening COPD, obstructive ventilator dysfunction, and obstructive small airway disease. Smoking cessation and controlling of relevant risk factors are helpful to lower the incidences of these conditions.
A: | yes
****
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example Input: Question: Are respiratory disorders more common in farmers . Results from a study on Icelandic animal farmers?
Answer: The prevalence of respiratory disorders and symptoms among Icelandic farmers is currently similar to non-farmers. This may suggest that modernization of the agricultural environment has had a positive effect on workers' health.
Example Output: no
Example Input: Question: Is neutrophil-lymphocyte ratio a reliable predictive marker for early-stage diabetic nephropathy?
Answer: Increased NLR was significantly associated with DN, and high NLR values may be a reliable predictive marker of early-stage DN.
Example Output: yes
Example Input: Question: Does methotrexate inhibit NF-κB activity via long intergenic ( noncoding ) RNA-p21 induction?
Answer: Our findings support a model whereby depressed levels of lincRNA-p21 in RA contribute to increased NF-κB activity. MTX decreases basal levels of NF-κB activity by increasing lincRNA-p21 levels through a DNA PKcs-dependent mechanism.
Example Output: | yes
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Example solution: yes
Example explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Problem: Question: Does inhibition of mitochondrial permeability transition pore restore the cardioprotection by postconditioning in diabetic hearts?
Answer: The loss of cardioprotection by IPostC in diabetic state can be overcome by increasing the potency of protective IPostC through its co-application with mPTP inhibition.
| Solution: yes | task846_pubmedqa_classification |
|
Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Are fundus autofluorescence lifetimes increased in non-proliferative diabetic retinopathy?
Answer: Fundus Fluorescence lifetimes are significantly increased in NPDR while lens lifetimes are shorter in the patient group. Lifetime changes might be indicative for the accumulation of advanced glycation end products (AGEs) which enables detection of the disease with high sensitivity and specificity possibly bearing diagnostic merit.
Student: | yes | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
One example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution is here: yes
Explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Now, solve this: Question: Are fundus autofluorescence lifetimes increased in non-proliferative diabetic retinopathy?
Answer: Fundus Fluorescence lifetimes are significantly increased in NPDR while lens lifetimes are shorter in the patient group. Lifetime changes might be indicative for the accumulation of advanced glycation end products (AGEs) which enables detection of the disease with high sensitivity and specificity possibly bearing diagnostic merit.
Solution: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Are c3 and C4 strongly related to adipose tissue variables and cardiovascular risk factors?
Answer: A strong relation between C3, C4 and C3a-desArg levels, adipose tissue and risk factors of CVD was established. The data support that the adipose tissue produces complement components and generates initiators of inflammation, such as C3a and C5a, able to trigger a cyto/chemokine response, in proportion to the amount of adipose tissue. This corroborates the concept that complement contributes to the low-grade inflammation associated with obesity.
A: yes
****
Q: Question: Is cDK10 a target for aberrant DNA methylation in breast cancer?
Answer: CDK10 is not a target for aberrant DNA methylation in breast cancer.
A: no
****
Q: Question: Is osteoprotegerin associated with subclinical left ventricular systolic dysfunction in diabetic hypertensive patients : a speckle tracking study?
Answer: Plasma OPG values could predict subclinical LV systolic dysfunction in diabetic hypertensive patients.
A: | yes
****
| task846_pubmedqa_classification |
|
You will be given a definition of a task first, then an example. Follow the example to solve a new instance of the task.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Why? The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
New input: Question: Is fasting serum dipeptidyl peptidase-4 activity independently associated with alanine aminotransferase in type 1 diabetic patients?
Answer: Fasting serum DPP4 activity might be associated with hepatic IR in T1DM patients and a part of soluble DPP4 activity might be of a hepatic origin. Further study investigation is warranted to elucidate this topic.
Solution: | yes | task846_pubmedqa_classification |
|
Given the task definition and input, reply with output. Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Do nondiabetic Mexican-Americans have reduced insulin responses relative to nondiabetic non-Hispanic whites?
Answer: These results suggest that increased insulin resistance rather than decreased insulin secretion is characteristic of nondiabetic Mexican-Americans, a high-risk population for NIDDM.
| no | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does the tissue Doppler imaging derived post-systolic velocity notch originate at the aortic annulus?
Answer: The AA represents the site of the earliest onset and maximal amplitude of the PSN on the longitudinal velocity curve suggesting its mechanism to be that of an energy release at the instant of the aortic valve closure causing an apically directed acceleration of the myocardium. A substantial number of healthy subjects exhibit a second PSN spike predominantly at the level of the AA. Its mechanism remains to be elucidated.
yes
Question: Does electrical stimulation prior to delayed reinnervation enhance recovery in muscles of rats?
Answer: The primary factors that inhibited reinnervation and recovery following delayed reinnervation were not alleviated by the electrical stimulation during the period of muscle denervation.
no
Question: Is fasting serum dipeptidyl peptidase-4 activity independently associated with alanine aminotransferase in type 1 diabetic patients?
Answer: Fasting serum DPP4 activity might be associated with hepatic IR in T1DM patients and a part of soluble DPP4 activity might be of a hepatic origin. Further study investigation is warranted to elucidate this topic.
| yes
| task846_pubmedqa_classification |
|
Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
See one example below:
Problem: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Problem: Question: Does periodontitis promote the diabetic development of obese rat via miR-147 induced classical macrophage activation?
Answer: This study provided new evidence for the positive effect of periodontal inflammation on diabetic development, while the regulatory mechanism of miR-147 on classical macrophage activation, was verified, and presumed to contribute to the impaired glucose tolerance aggravated by periodontitis in obese rats. Besides, this study indicated the application of miR-147 for therapeutic approach in the treatment of diabetes with periodontitis.
Solution: | yes | task846_pubmedqa_classification |
|
TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Does ginsenoside Rg3 improve erectile function in streptozotocin-induced diabetic rats?
Answer: Oral gavage with Rg3 appears to both prevent degeneration of neurons in the dorsal nerves and exert an antioxidant effect in the corpus cavernosum of rats.
SOLUTION: yes
PROBLEM: Question: Does identification of structural alert for liver and kidney toxicity using repeated dose toxicity data?
Answer: It was not possible to assign an unambiguous mode of action for all the SAs, but a mechanistic explanation is provided for some of them. Such achievements may help in the early identification of liver and renal toxicity of substances.
SOLUTION: yes
PROBLEM: Question: Does partial meniscectomy in the presence of severe osteoarthritis hasten the symptomatic progression of osteoarthritis?
Answer: Arthroscopic partial meniscectomy in the presence of Outerbridge grade IV degenerative change is likely to improve symptoms initially in patients with symptomatic meniscal tears and may provide lasting benefit. It does not appear to hasten the progression of the osteoarthritis in these patients.
SOLUTION: | no
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[EX Q]: Question: Is visceral pleural invasion a significant prognostic factor in patients with a part-solid lung cancer?
Answer: VPI may not contribute to the prognosis of patients with part-solid nodules. Thus, upgrading of the TNM stage on the basis of VPI should be carefully considered in these patients.
[EX A]: no
[EX Q]: Question: Is health seeking behaviour of parents of burned children in Bangladesh related to family socioeconomics?
Answer: Education, economic condition and place of residence were found as the contributory factors in choosing service provider. Education to the parents can contribute in changes in health seeking behaviour which ultimately contribute in reducing morbidity and mortality from childhood burn injuries. Including parent's education a national burn prevention program needs to be developed to combat the devastating child injury, burn.
[EX A]: yes
[EX Q]: Question: Is regular Chinese Green Tea Consumption Protective for Diabetic Retinopathy : A Clinic-Based Case-Control Study?
Answer: Diabetic patients who had regularly drunk Chinese green tea every week for at least one year in their lives had a DR risk reduction of about 50% compared with those who had not. Regular Chinese green tea consumption may be a novel approach for the prevention of DR.
[EX A]: | yes
| task846_pubmedqa_classification |
|
You will be given a definition of a task first, then some input of the task.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does ginsenoside Rg3 improve erectile function in streptozotocin-induced diabetic rats?
Answer: Oral gavage with Rg3 appears to both prevent degeneration of neurons in the dorsal nerves and exert an antioxidant effect in the corpus cavernosum of rats.
Output: | yes | task846_pubmedqa_classification |
|
Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Problem:Question: Is serum paraoxonase-1 activity more closely related to HDL particle concentration and large HDL particles than to HDL cholesterol in Type 2 diabetic and non-diabetic subjects?
Answer: PON-1 activity is more closely related to the HDL particle concentration or large HDL particles than to HDL cholesterol. Impaired PON-1 activity in T2DM is not to a considerable extent explained by altered HDL subfraction levels.
Solution: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Consider Input: Question: Does serum HCV RNA titer predict the severity of liver damage in HCV carriers with normal aminotransferase levels?
Answer: In HCV carriers with normal aminotransferase levels viraemia does not predict the grade of HCV-related chronic liver disease (CLD), although subjects with higher HCV RNA levels seem to have more severe fibrosis. Although these data suggest that patients with higher viraemia might have more intense architectural changes and more severe progression of liver disease than those with lower levels of HCV replication, the weak and imprecise correlation leads us to conclude that HCV RNA quantitation is not a useful indicator in clinical practice in the selection of patients for liver biopsy.
Output: no
Input: Consider Input: Question: Does thickness of CAD-CAM composite resin overlay influences fatigue resistance of endodontically treated premolars?
Answer: Thick FiltekMZ100 composite resin onlays showed higher fatigue resistance than thin ones and may be associated with fractures that are less subgingival.
Output: yes
Input: Consider Input: Question: Is decline in functional capacity unaffected by diet quality alone or in combination with physical activity among generally healthy older adults with T2D from the NuAge cohort?
Answer: The absence of effect may be explained by characteristics of this healthy sample of OA with T2D who showed relatively good adherence to dietary recommendations (mean C-HEI=70) and were highly functional shown by minimal, clinically non-significant FC decline over 3 years. More research is needed to confirm the role of DQ in preventing FC decline in a larger diabetic sample showing clinically significant FC decline.
| Output: yes
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Example solution: yes
Example explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Problem: Question: Does a diabetes scorecard improve HbA ( 1c ) , blood pressure , lipids , aspirin usage , exercise and diabetes knowledge over 9 months : a randomized controlled trial?
Answer: A diabetes scorecard did not improve glycaemic control, blood pressure control, LDL cholesterol, aspirin usage, exercise or diabetic knowledge in an urban population with uncontrolled Type 2 diabetes.
| Solution: no | task846_pubmedqa_classification |
|
Part 1. Definition
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Part 2. Example
Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Answer: yes
Explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Part 3. Exercise
Question: Does digoxin accelerate progression of diabetic retinopathy?
Answer: These data suggest that digoxin therapy does not adversely affect the course of diabetic retinopathy.
Answer: | no | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[Q]: Question: Is time point important for effects of syngeneic bone marrow transplantation for type 1 diabetes in mice?
Answer: These results indicated that syn-BMT should be performed, when diabetes is neither too new-onset nor too late-stage. Tregs represent one mechanism for syn-BMT-induced restoration of immune tolerance in STZ-diabetic mice.
[A]: yes
[Q]: Question: Do natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation?
Answer: Overall, we provide a significant insight into the anticarcinogenic action of erythrodiol and uvaol that may have a potential in prevention and treatment of brain tumors and other cancers.
[A]: yes
[Q]: Question: Is vEGF , VEGFR3 , and PDGFRB protein expression influenced by RAS mutations in medullary thyroid carcinoma?
Answer: This is the first study identifying that the expression of TKI targets differs according to the presence of RAS mutations in MTC. This information could potentially be used to select the most beneficial TKI treatment for these patients.
[A]: | yes
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Example solution: yes
Example explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Problem: Question: Does induced-hyperglycemia attenuate erythromycin-induced acceleration of hypertonic liquid-phase gastric emptying in type-I diabetic patients?
Answer: The erythromycin-induced acceleration on gastric emptying of hypertonic liquids in diabetic patients is related to the plasma glucose level. The induced hyperglycemia reduces the erythromycin-induced acceleration of liquid-phase gastric emptying, decreasing the overall gastric emptying rate. In spite of the inhibitory effect of induced hyperglycemia on the gastric emptying of hypertonic liquids, erythromycin is still able to accelerate the emptying rate and could prove to be a useful prokinetic agent under hyperglycemic conditions.
| Solution: yes | task846_pubmedqa_classification |
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Given the task definition and input, reply with output. Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Do serum miRNA biomarkers serve as a fingerprint for proliferative diabetic retinopathy?
Answer: These data provide evidence that serum miRNAs have the potential to be sensitive, cost-effective biomarkers for the early detection of PDR. These biomarkers could serve as a dynamic monitoring factor for detecting the progression of PDR from NPDR.
| yes | task846_pubmedqa_classification |
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You will be given a definition of a task first, then some input of the task.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Is myostatin expression altered by insulin deficiency and replacement in streptozotocin-diabetic rat skeletal muscles?
Answer: Muscle-specific myostatin expression is not increased under catabolic conditions in insulin-deprived diabetes. Insulin treatment also does not change myostatin transcript levels. The data provide the first assessment of potential interplay between insulin and myostatin and they do not support a major role of circulating insulin in the in vivo regulation of myostatin gene expression. A role of myostatin in muscle catabolism in chronic insulin-deprived diabetes is also not indicated by the current results.
Output: | no | task846_pubmedqa_classification |
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Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Question: Does formononetin attenuate hydrogen peroxide ( H2O2 ) -induced apoptosis and NF-κB activation in RGC-5 cells?
Answer: Formononetin may be developed as a antioxidant drug to treat diabetic retinopathy.
Output: | yes | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[EX Q]: Question: Does oligofructose affect the development of type 1 diabetes mellitus induced by dietary proteins in the diabetes-prone BB rat model?
Answer: In the BB rat model, 5% OF in the diet did not have any protective effects against diet-induced T1DM. The present data do not suggest dietary OF as a promising approach for the dietary prevention of T1DM.
[EX A]: no
[EX Q]: Question: Does combined isometric and vibration training enhance strength beyond that of isometric training alone?
Answer: The present study provides evidence to suggest that there are no greater gains to be incurred by the addition of a vibratory stimulus to traditional strength training.
[EX A]: no
[EX Q]: Question: Is mean platelet volume associated with glycaemic control and retinopathy in patients with type 2 diabetes mellitus?
Answer: This study has shown that an increased MPV is closely associated with poor glycaemic control, which may be a risk factor for diabetic retinopathy. Nonetheless, further prospective studies are needed to assess the relationship between MPV, glycaemic indices and microvascular complications.
[EX A]: | yes
| task846_pubmedqa_classification |
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Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Do monocytes and neutrophils expressing myeloperoxidase occur in fibrous caps and thrombi in unstable coronary plaques?
Answer: Unstable fibrous caps are more likely to contain MPO-positive cells, neutrophils, and iron-containing macrophages than fibrous caps of stable fibroatheromas. MPO-positive cells in thrombi adjacent to disrupted plaques are associated with occlusive thrombi and are more numerous in diabetic patients.
Student: | yes | task846_pubmedqa_classification |
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Given the task definition and input, reply with output. Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does suv39h1 protect from myocardial ischemia-reperfusion injury in diabetic rats?
Answer: Overexpression of Suv39h1 results in the de-activation of proinflammatory pathways and reduced apoptosis and myocardial injury. Therefore, Suv39h1 might represent a novel therapeutic strategy to reduce I/R injury under diabetic condition.
| yes | task846_pubmedqa_classification |
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Teacher: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? If you are still confused, see the following example:
Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Reason: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Now, solve this instance: Question: Is methylglyoxal associated with changes in kidney function among individuals with screen-detected Type 2 diabetes mellitus?
Answer: In a population of people with screen-detected Type 2 diabetes, we observed associations between methylglyoxal and markers of renal function: 6-year change in methylglyoxal was inversely associated with 6-year change in eGFR. Also, methylglyoxal at baseline was positively associated with ACR at baseline. Our study lends further support to a role for methylglyoxal in the pathogenesis of diabetic nephropathy.
Student: | yes | task846_pubmedqa_classification |
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instruction:
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
question:
Question: Is time point important for effects of syngeneic bone marrow transplantation for type 1 diabetes in mice?
Answer: These results indicated that syn-BMT should be performed, when diabetes is neither too new-onset nor too late-stage. Tregs represent one mechanism for syn-BMT-induced restoration of immune tolerance in STZ-diabetic mice.
answer:
yes
question:
Question: Is lipoprotein internalisation induced by oncogenic AMPK activation essential to maintain glioblastoma cell growth?
Answer: Our findings demonstrate that AMPK plays a crucial role in glioblastoma cell growth and suggest that blocking lipoprotein receptors could potentially be used as a plausible therapeutic approach for these and other type of tumours with high levels of AMPK.
answer:
yes
question:
Question: Is ischemic preconditioning cardioprotective in senescent human myocardium?
Answer: Our data indicate that ischemic preconditioning has no beneficial effect on the postischemic functional recovery of senescent human myocardium.
answer:
| no
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
One example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution is here: yes
Explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Now, solve this: Question: Does co-Transplantation of Skin-Derived Precursors and Collagen Sponge facilitate Diabetic Wound Healing by Promoting Local Vascular Regeneration?
Answer: Accelerated wound healing and enhanced local capillary regeneration could be observed 14 days after skin ablation from both SKPs and collagen sponge co-transplanted and collagen sponge only groups. Subsequent analyses further revealed superior pro-angiogenic effects from the SKP and collagen sponge co-delivered group, which are mainly attributable to in vivo transdifferentation and paracrine signalling of the SKPs.
Solution: | yes | task846_pubmedqa_classification |
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Q: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does blockade of p38 mitogen-activated protein kinase pathway ameliorate delayed gastric emptying in streptozotocin-induced diabetic rats?
Answer: Inflammation was associated with the development of delayed gastric emptying, and blockade of p38 MAPK pathway with SB203580 ameliorates delayed gastric emptying in diabetic rats, at least in part, by inhibiting the expression of iNOS, TNF-a and IL-1β. Therefore, p38MAPK may serve as a novel target for the therapy of diabetes-related gastrointestinal dysmotility.
A: | yes | task846_pubmedqa_classification |
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You will be given a definition of a task first, then an example. Follow the example to solve a new instance of the task.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Why? The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
New input: Question: Does mild-to-moderate intensity exercise improve cardiac autonomic drive in type 2 diabetes?
Answer: These data suggest that three times per week moderate intensity aerobic exercise for 6 months improves cardiac rhythm regulation as measured by heart rate variability in type 2 diabetic patients.
Solution: | yes | task846_pubmedqa_classification |
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Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Is the high prevalence of autoantibodies to tissue transglutaminase in first-degree relatives of patients with type 1 diabetes associated with islet autoimmunity?
Answer: We found a high prevalence of celiac autoimmunity in patients and first-degree relatives of children with type 1 diabetes, but we found limited overlap between islet and celiac autoimmunity in nondiabetic relatives. The high prevalence of celiac autoimmunity may be explained by shared genetic susceptibility and identifies a population within which screening for the disease may be justified.
Student: | no | task846_pubmedqa_classification |
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Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Does autophagy protect human podocytes from high glucose-induced injury by preventing insulin resistance?
Answer: The presence or activation of autophagy was found to play a protective role in human podocytes against high glucose-induced insulin resistance and cell injury, which indicates a novel cellular mechanism and provides a potential therapeutic target for diabetic nephropathy (DN).
Student: | yes | task846_pubmedqa_classification |
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Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Problem:Question: Is increased urine semaphorin-3A associated with renal damage in hypertensive patients with chronic kidney disease : a nested case-control study?
Answer: USEMA is independently associated with CKD in both diabetic and non diabetic hypertensive patients. Further studies may help clarify the mechanisms underlying this association and possibly the pathogenic changes leading to the development of CKD.
Solution: | yes | task846_pubmedqa_classification |
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Teacher: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? If you are still confused, see the following example:
Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Reason: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Now, solve this instance: Question: Is whole-body heat loss during exercise in the heat impaired in type 1 diabetes?
Answer: During light-to-moderate-intensity exercise performed under conditions permitting full sweat evaporation, otherwise healthy type 1 diabetic individuals did not show impaired heat loss responses during heat exposure when compared with matched individuals without diabetes.
Student: | no | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
One example is below.
Q: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
A: yes
Rationale: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Q: Question: Does blocking ET-1 receptors correct subnormal retinal oxygenation response in experimental diabetic retinopathy?
Answer: Because subnormal retinal DeltaPo(2) after drug treatment is a biomarker of subsequent vascular histopathology, the present data raise the possibility that retinal ET-1 does not play a key role in the pathogenesis of diabetic retinopathy.
A: | no | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Does converging evidence implicate the abnormal microRNA system in schizophrenia?
Answer: Collectively, results from all 3 lines of evidence, suggest that the genetically based dysregulation of miRNA systems undermines miRNAs' inhibitory effects, resulting in the abnormal upregulation of genome transcription in the development of SZ.
A: yes
****
Q: Question: Does diabetes influence oral oncogenesis through fibroblast growth factor receptors?
Answer: It seems that diabetes does not affect the FGFR-2 and FGFR-3 pattern of expression throughout the various stages of oral oncogenesis.
A: no
****
Q: Question: Does periodontitis promote the diabetic development of obese rat via miR-147 induced classical macrophage activation?
Answer: This study provided new evidence for the positive effect of periodontal inflammation on diabetic development, while the regulatory mechanism of miR-147 on classical macrophage activation, was verified, and presumed to contribute to the impaired glucose tolerance aggravated by periodontitis in obese rats. Besides, this study indicated the application of miR-147 for therapeutic approach in the treatment of diabetes with periodontitis.
A: | yes
****
| task846_pubmedqa_classification |
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Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Problem:Question: Does naked plasmid-mediated gene transfer to skeletal muscle ameliorate diabetes mellitus?
Answer: Skeletal muscle is a potentially useful platform for ectopic secretion of insulin using naked plasmid as a gene transfer vector. Injection at two sites 14 days before the onset of severe hyperglycemia is optimal. This approach could protect Type I diabetics from fatal ketoacidosis and enhance the action of agents that sensitize tissues to insulin in type II diabetes.
Solution: | yes | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
--------
Question: Question: Does co-Transplantation of Skin-Derived Precursors and Collagen Sponge facilitate Diabetic Wound Healing by Promoting Local Vascular Regeneration?
Answer: Accelerated wound healing and enhanced local capillary regeneration could be observed 14 days after skin ablation from both SKPs and collagen sponge co-transplanted and collagen sponge only groups. Subsequent analyses further revealed superior pro-angiogenic effects from the SKP and collagen sponge co-delivered group, which are mainly attributable to in vivo transdifferentation and paracrine signalling of the SKPs.
Answer: yes
Question: Question: Does classical swine fever virus induce oxidative stress in swine umbilical vein endothelial cells?
Answer: Our results indicated that CSFV infection induced oxidative stress in SUVECs. These findings provide novel information on the mechanism by which CSFV can alter intracellular events associated with the viral infection.
Answer: yes
Question: Question: Is increased insulin-like growth factor 1 production by human osteoarthritic chondrocytes dependent on growth hormone action?
Answer: This study indicates that the elevated synthesis of IGF-1 by adult human OA chondrocytes occurs through a GH/GHR-independent mechanism, suggesting that other factors are capable of controlling local IGF-1 production in these cells.
Answer: | no
| task846_pubmedqa_classification |
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Given the task definition, example input & output, solve the new input case.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Output: yes
The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
New input case for you: Question: Are diabetes and increased lipid peroxidation associated with systemic inflammation even in well-controlled patients?
Answer: These findings show that dyslipidemia is associated with an increased inflammatory status, even in well-controlled diabetics and in normoglycemics. Our results suggest that lipid metabolism and peroxidation are important for the development of inflammation, which is elevated in several complications associated with diabetes.
Output: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
One example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution is here: yes
Explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Now, solve this: Question: Is regular Chinese Green Tea Consumption Protective for Diabetic Retinopathy : A Clinic-Based Case-Control Study?
Answer: Diabetic patients who had regularly drunk Chinese green tea every week for at least one year in their lives had a DR risk reduction of about 50% compared with those who had not. Regular Chinese green tea consumption may be a novel approach for the prevention of DR.
Solution: | yes | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does pluronic L-81 ameliorate diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein?
Answer: L-81 represents a promising candidate in the development of a selective insulin-mimetic molecule and an anti-diabetic agent. | yes | task846_pubmedqa_classification |
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TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Is lubricin a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts?
Answer: Lubricin is secreted by synovial fibroblasts via expression of the MSF gene. Lubricin is constructed of MSF exons 6 through 9 but the presence of other exons cannot be excluded. Lubricin/MSF is the only lubricating component in the final lubricating fraction of human synovial fluid.
SOLUTION: yes
PROBLEM: Question: Is neutrophil-lymphocyte ratio a reliable predictive marker for early-stage diabetic nephropathy?
Answer: Increased NLR was significantly associated with DN, and high NLR values may be a reliable predictive marker of early-stage DN.
SOLUTION: yes
PROBLEM: Question: Is expression of heat shock protein 60 kDa upregulated in cervical cancer?
Answer: These results suggest that HSP60 may be involved in the development of cervical cancer and have profound biological and prognostic significance.
SOLUTION: | yes
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Ex Input:
Question: Is herpes simplex virus type 1 transcription detectable in quiescent human stromal keratitis by in situ hybridization?
Answer: At the level of detection afforded by in situ hybridization, HSV persistent in scarred human corneas after stromal keratitis appears to be transcriptionally dormant. This contrasts with the situation in neurons of latently infected sensory ganglia, in which LATs are present at high levels.
Ex Output:
no
Ex Input:
Question: Does ginsenoside Rg3 improve erectile function in streptozotocin-induced diabetic rats?
Answer: Oral gavage with Rg3 appears to both prevent degeneration of neurons in the dorsal nerves and exert an antioxidant effect in the corpus cavernosum of rats.
Ex Output:
yes
Ex Input:
Question: Does endometrial infusion of human chorionic gonadotropin at the time of blastocyst embryo transfer impact clinical outcomes : a randomized , double-blind , placebo-controlled trial?
Answer: Endometrial infusion of hCG at the time of blastocyst ET does not improve sustained implantation rates.
Ex Output:
| no
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Ex Input:
Question: Are leg muscle reflexes mediated by cutaneous A-beta fibres normal during gait in reflex sympathetic dystrophy?
Answer: In the acute phase of RSD of the lower extremity there is no evidence for abnormal A-beta fibre-mediated reflexes or for defective regulation of such reflexes. This finding has implications for both the theory on RSD pathophysiology and RSD models, which are based on abnormal functioning of A-beta fibres.
Ex Output:
yes
Ex Input:
Question: Is the female protective effect in autism spectrum disorder mediated by a single genetic locus?
Answer: The results do not support the hypothesis that the FPE is mediated by a single genetic locus; however, this does not exclude the possibility of multiple genetic loci playing a role in the FPE.
Ex Output:
no
Ex Input:
Question: Does sevoflurane alter norepinephrine-induced intracellular Ca² ( + ) changes in the diabetic rat aorta?
Answer: Sevoflurane at clinically relevant concentrations inhibited the NE-induced increase in [Ca²(+)](i) in the aortic smooth muscle from normal rats but not in that from type 2 DM rats. Thus, a Ca²(+)- signalling pathway resistant to sevoflurane appears to exist in the type 2 DM rat aorta.
Ex Output:
| no
| task846_pubmedqa_classification |
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Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Problem:Question: Does abciximab reduce mortality in diabetics following percutaneous coronary intervention?
Answer: Abciximab decreases the mortality of diabetic patients to the level of placebo-treated nondiabetic patients. This beneficial effect is noteworthy in those diabetic patients who are also hypertensive and obese and in diabetics undergoing multivessel intervention. Besides its potential role in reducing repeat intervention for stented diabetic patients, abciximab therapy should be strongly considered in diabetic patients undergoing PCI to improve their survival.
Solution: | yes | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Ex Input:
Question: Is premature immunosenescence associated with memory dysfunction in rheumatoid arthritis?
Answer: RA patients had reduced memory performance compared to healthy controls. Expansion of activated and senescence-associated T cells was correlated with poor memory performance.
Ex Output:
yes
Ex Input:
Question: Do workers of a drywood termite work?
Answer: Thus, in contrast to general perception where termite workers are considered equivalent to workers in Hymenoptera, the 'large immatures' of C. secundus did not behave as workers that help in raising younger siblings. This apparently is not necessary as the colony lives inside its food. These results, which are likely to be typical for wood-dwelling termites, open the possibility that large complex group living can evolve without altruistic helping and that costly altruistic helping by workers in termites evolved only as a second step.
Ex Output:
no
Ex Input:
Question: Are diabetes and increased lipid peroxidation associated with systemic inflammation even in well-controlled patients?
Answer: These findings show that dyslipidemia is associated with an increased inflammatory status, even in well-controlled diabetics and in normoglycemics. Our results suggest that lipid metabolism and peroxidation are important for the development of inflammation, which is elevated in several complications associated with diabetes.
Ex Output:
| yes
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Does periodontitis promote the diabetic development of obese rat via miR-147 induced classical macrophage activation?
Answer: This study provided new evidence for the positive effect of periodontal inflammation on diabetic development, while the regulatory mechanism of miR-147 on classical macrophage activation, was verified, and presumed to contribute to the impaired glucose tolerance aggravated by periodontitis in obese rats. Besides, this study indicated the application of miR-147 for therapeutic approach in the treatment of diabetes with periodontitis.
A: | yes | task846_pubmedqa_classification |
|
Q: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Is gender related to alterations of renal endothelial function in type 2 diabetes?
Answer: Our data demonstrate that NO availability in the renal circulation is greater in female than in male patients with type 2 diabetes that is associated with reduced levels of oxidative stress in females. The role of this gender-related difference in renal endothelial function for the initiation and progression of diabetic nephropathy should be addressed in future studies.
A: | yes | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Consider Input: Question: Is cytoplasmic expression of β-catenin an independent predictor of progression of conventional renal cell carcinoma : a simple immunostaining score?
Answer: Cytoplasmic β-catenin expression is an independent prognostic factor for conventional RCC, and may help to identify patients with a high risk of cancer-specific death and to direct optimized active surveillance or adjuvant therapy.
Output: yes
Input: Consider Input: Question: Are anticytomegalovirus antibody titres associated with caregiving burden in younger caregivers?
Answer: These data suggest that in the absence of immunosenescence, the chronic stress of caregiving is not sufficient to compromise the immune response to persistent CMV infection. However, an indirect mechanism to poorer health in caregivers might be via adoption of disadvantageous health behaviours in response to stress. Statement of contribution What is already known on this subject? Older caregivers of spouses with dementia show a poorer immune response against latent viruses when compared to age- and sex-matched controls. Younger parental caregivers of children with developmental disabilities show a poorer antibody response to vaccination. What does this study add? The study showed no association between caregiving stress and CMV antibody titre in young caregivers. There were higher CMV antibody titres in the caregivers who engage in unhealthy behaviours.
Output: no
Input: Consider Input: Question: Is whole-body heat loss during exercise in the heat impaired in type 1 diabetes?
Answer: During light-to-moderate-intensity exercise performed under conditions permitting full sweat evaporation, otherwise healthy type 1 diabetic individuals did not show impaired heat loss responses during heat exposure when compared with matched individuals without diabetes.
| Output: no
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Is neutrophil-lymphocyte ratio a reliable predictive marker for early-stage diabetic nephropathy?
Answer: Increased NLR was significantly associated with DN, and high NLR values may be a reliable predictive marker of early-stage DN. | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example Input: Question: Does clinical examination assist in the detection of systemic relapse of testicular germ cell tumour?
Answer: We suggest that, for patients following a planned programme of appointments and investigations, physical examination rarely contributes to the detection of systemic relapse in the follow-up of testicular germ cell tumours. It may therefore be possible to reconfigure follow-up to focus on investigations and telephone contact. We estimate that this change might be appropriate for 40% of attendances and might be welcomed by patients, many of whom find follow-up burdensome. If such a change were considered, patient education would be essential to ensure continuing compliance with the follow-up protocol.
Example Output: no
Example Input: Question: Do an update in the palliative management of malignant dysphagia?
Answer: Palliative treatment for oesophageal cancer should be individualized and relate to tumour stage, size and location, the patient's medical condition and his/her personal wishes. The palliative treatment largely includes self-expanding metal stents (SEMS), laser (including photodynamic therapy (PDT)) or a combination of the two to relieve symptoms, this may be employed with or without other treatments such as radiotherapy/chemotherapy (RT/CT) with the aim of reducing tumour bulk and possibly prolonging survival. A multi-disciplinary approach is vital in patients with advanced oesophageal cancer.
Example Output: yes
Example Input: Question: Does formononetin attenuate hydrogen peroxide ( H2O2 ) -induced apoptosis and NF-κB activation in RGC-5 cells?
Answer: Formononetin may be developed as a antioxidant drug to treat diabetic retinopathy.
Example Output: | yes
| task846_pubmedqa_classification |
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Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Is mean platelet volume associated with glycaemic control and retinopathy in patients with type 2 diabetes mellitus?
Answer: This study has shown that an increased MPV is closely associated with poor glycaemic control, which may be a risk factor for diabetic retinopathy. Nonetheless, further prospective studies are needed to assess the relationship between MPV, glycaemic indices and microvascular complications.
Student: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does [ Sildenafil change coronary flow reserve in diabetics with erectile dysfunction ]?
Answer: Diabetics with erectile dysfunction often have a CFR in the lower range of normal. Sildenafil did not further reduce CFR. Asymptomatic, severe coronary artery disease often can be found in diabetics with erectile dysfunction. Cardiological screening for contraindications for sildenafil seems mandatory in diabetics with a high cardiovascular risk profile. | no | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
--------
Question: Question: Is retinol-binding protein-4 strongly associated with insulin sensitivity in normal pregnancies?
Answer: The increased fat mass and insulin resistance during normal pregnancy was best explained by measures of fat mass. However, the increase in RBP4 from early to late pregnancy, associated with a decline in insulin sensitivity, potentially indicates interactions with glucose metabolism.
Answer: no
Question: Question: Do novel meta-analysis-derived type 2 diabetes risk loci determine prediabetic phenotypes?
Answer: In contrast to the first series of GWA-derived type 2 diabetes candidate SNPs, we could not detect reliable associations of the novel risk loci with prediabetic phenotypes. Possible weak effects of ADAMTS9 SNP rs4607103 and VEGFA SNP rs9472138 on insulin sensitivity and insulin secretion, respectively, await further confirmation by larger studies.
Answer: no
Question: Question: Is the structure of the von Willebrand factor altered in patients with colorectal carcinoma?
Answer: There was no change in the VWF multimer distribution to indicate acquired von Willebrand disease.
Answer: | no
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example Input: Question: Does histologic evaluation of in vivo femtosecond laser-generated capsulotomies reveal a potential cause for radial capsular tears?
Answer: Femtosecond laser can perform a capsulotomy with high reliability. In comparison to a highly experienced cataract surgeon, the achieved results in size are similar. In terms of circularity, the femtosecond laser was superior the manual procedure. Better refractive outcomes based on a 360°-degree optic overlap seem to be possible, especially for less experienced surgeons.
Example Output: yes
Example Input: Question: Does classical swine fever virus induce oxidative stress in swine umbilical vein endothelial cells?
Answer: Our results indicated that CSFV infection induced oxidative stress in SUVECs. These findings provide novel information on the mechanism by which CSFV can alter intracellular events associated with the viral infection.
Example Output: yes
Example Input: Question: Is birth weight related to risk of diabetic retinopathy in type 2 diabetes : the Atherosclerosis Risk in Communities Study?
Answer: Birth weight was not associated with diabetic retinopathy.
Example Output: | no
| task846_pubmedqa_classification |
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TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Does inhibition of late sodium current attenuate ionic arrhythmia mechanism in ventricular myocytes expressing LaminA-N195K mutation?
Answer: Inhibition of late I
SOLUTION: yes
PROBLEM: Question: Is the diagnosis of inflammatory bowel disease often unsupported in clinical practice?
Answer: Our study showed that the diagnostic prerequisites were widely unfulfilled, although approximately half of the diagnoses were conclusive for inflammatory bowel disease. Thus, in our assessment of clinical practice: (1) clinicians seldom provide suitable clinical and/or endoscopic information for a histological diagnosis and (2) histopathological diagnoses of inflammatory bowel disease are often not supported by morphology.
SOLUTION: yes
PROBLEM: Question: Is elevated alanine aminotransferase activity associated with dyslipidemias , but related to insulin resistance and higher disease grades in non-diabetic non-alcoholic fatty liver disease?
Answer: This study shows that the associations of increased ALT serum levels in NAFLD patients are different from what are supposed before. By excluding diabetic patients from our population, we find that increased ALT levels are not associated with dyslipidemias but are independently associated with insulin resistance and NAFLD grading on ultrasonographic evaluations. Further studies are needed to confirm our results.
SOLUTION: | no
| task846_pubmedqa_classification |
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Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Does glibenclamide attenuate myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic mice?
Answer: We conclude that glibenclamide could attenuate myocardial injury induced by LPS challenge in STZ-mice, which was possibly related to inhibiting inflammation through Nalp3 inflammasomes.
A: | yes | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Is s100A8/A9 involved in host defense against murine urinary tract infection?
Answer: We show that despite high S100A8/A9 expression in bladder and kidney tissue upon UTI, S100A8/A9 does not contribute to an effective host response against E. Coli in the urinary tract system.
A: no
****
Q: Question: Does ginsenoside Rg3 improve erectile function in streptozotocin-induced diabetic rats?
Answer: Oral gavage with Rg3 appears to both prevent degeneration of neurons in the dorsal nerves and exert an antioxidant effect in the corpus cavernosum of rats.
A: yes
****
Q: Question: Does the Drosophila Chmp1 protein determine wing cell fate through regulation of epidermal growth factor receptor signaling?
Answer: Drosophila Chmp1 negatively regulates DER signaling, likely through its role in MVB formation. Loss of Chmp1 activity in the Drosophila wing induces a cell fate change from intervein to vein that should provide a useful tool for future studies of ESCRT protein activity.
A: | yes
****
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Does co-Transplantation of Skin-Derived Precursors and Collagen Sponge facilitate Diabetic Wound Healing by Promoting Local Vascular Regeneration?
Answer: Accelerated wound healing and enhanced local capillary regeneration could be observed 14 days after skin ablation from both SKPs and collagen sponge co-transplanted and collagen sponge only groups. Subsequent analyses further revealed superior pro-angiogenic effects from the SKP and collagen sponge co-delivered group, which are mainly attributable to in vivo transdifferentation and paracrine signalling of the SKPs.
A: yes
****
Q: Question: Do extremely cold and hot temperatures increase the risk of diabetes mortality in metropolitan areas of two Chinese cities?
Answer: The results indicate that both extremely cold and hot temperatures increase diabetes mortality in different manners in Harbin and Chongqing. Diabetes education programs should include information on either managing or combating the effects of extreme hot and cold weather.
A: yes
****
Q: Question: Does intravenous insulin therapy during lung resection affect lung function or surfactant proteins?
Answer: According to our observations, short insulin treatment applied intravenously during resection does not affect the quality of breathing.
A: | no
****
| task846_pubmedqa_classification |
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Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Is regular Chinese Green Tea Consumption Protective for Diabetic Retinopathy : A Clinic-Based Case-Control Study?
Answer: Diabetic patients who had regularly drunk Chinese green tea every week for at least one year in their lives had a DR risk reduction of about 50% compared with those who had not. Regular Chinese green tea consumption may be a novel approach for the prevention of DR.
Student: | yes | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
--------
Question: Question: Is time point important for effects of syngeneic bone marrow transplantation for type 1 diabetes in mice?
Answer: These results indicated that syn-BMT should be performed, when diabetes is neither too new-onset nor too late-stage. Tregs represent one mechanism for syn-BMT-induced restoration of immune tolerance in STZ-diabetic mice.
Answer: yes
Question: Question: Are circulating levels of IL-1beta , a prothrombotic cytokine , elevated in unstable angina versus stable angina?
Answer: Our results suggest that both IL-1beta and IL-6 contribute to the pathogenesis of unstable angina, and that the profile of circulating plasma levels of proinflammatory cytokines differs in unstable angina from that in stable angina. Abbreviated Abstract. Multiple studies support a role for inflammation in the pathogenesis of coronary atherosclerosis and unstable cardiac syndromes. We measured plasma levels of interleukin-1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) in patients with stable and unstable coronary syndromes. Levels of IL-1beta and IL-6 were found to be elevated in patients with unstable coronary syndromes. No significant differences were found in the levels of TNF-alpha. Our results suggest that both IL-1beta and IL-6 contribute to the pathogenesis of unstable angina.
Answer: yes
Question: Question: Does single oral dose of maraviroc prevent ex-vivo HIV infection of rectal mucosa in HIV-1 negative human volunteers?
Answer: An ex-vivo challenge with a single oral dose of MVC does not prevent ex-vivo infection of human rectal mucosa. The lack of prophylactic efficacy observed suggests that 'on demand' MVC preexposure prophylaxis would not prevent rectal HIV-1 transmission.
Answer: | no
| task846_pubmedqa_classification |
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Q: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does common sequence variation in the VEGFA gene predict risk of diabetic retinopathy?
Answer: Sequence variation in the VEGFA gene is associated with risk of developing blinding DR in T1DM and T2DM. Identifying specific genetic markers will allow for refined screening algorithms and earlier intervention in patients at highest risk.
A: | yes | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Consider Input: Question: Are respiratory disorders more common in farmers . Results from a study on Icelandic animal farmers?
Answer: The prevalence of respiratory disorders and symptoms among Icelandic farmers is currently similar to non-farmers. This may suggest that modernization of the agricultural environment has had a positive effect on workers' health.
Output: no
Input: Consider Input: Question: Is hIC2 a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region?
Answer: Our results demonstrate a novel role for Hic2 in cardiac development. Hic2 is the first gene within the distal 22q11 interval to have a demonstrated haploinsufficient cardiac phenotype in mice. Together our data suggest that HIC2 haploinsufficiency likely contributes to the cardiac defects seen in distal 22q11 deletion syndrome.
Output: yes
Input: Consider Input: Question: Is glycemic variability evaluated by continuous glucose monitoring system associated with the 10-y cardiovascular risk of diabetic patients with well-controlled HbA1c?
Answer: GV predicts independently the 10-y CVD risk of T2DM patients with well-controlled HbA1c.
| Output: yes
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
--------
Question: Question: Does ondansetron reduce the shivering threshold in healthy volunteers?
Answer: /b>. Ondansetron appears to have little potential for facilitating induction of therapeutic hypothermia.
Answer: no
Question: Question: Do elevated S100B levels correlate with the severity of encephalopathy during sepsis?
Answer: In severe sepsis, an increase in S100B does not allow the physicians to distinguish patients with severe impairment of consciousness from those with milder derangements or to prognosticate neurological recovery.
Answer: no
Question: Question: Does digoxin accelerate progression of diabetic retinopathy?
Answer: These data suggest that digoxin therapy does not adversely affect the course of diabetic retinopathy.
Answer: | no
| task846_pubmedqa_classification |
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Definition: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Question: Is decline in functional capacity unaffected by diet quality alone or in combination with physical activity among generally healthy older adults with T2D from the NuAge cohort?
Answer: The absence of effect may be explained by characteristics of this healthy sample of OA with T2D who showed relatively good adherence to dietary recommendations (mean C-HEI=70) and were highly functional shown by minimal, clinically non-significant FC decline over 3 years. More research is needed to confirm the role of DQ in preventing FC decline in a larger diabetic sample showing clinically significant FC decline.
Output: | yes | task846_pubmedqa_classification |
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Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Question: Is birth weight related to risk of diabetic retinopathy in type 2 diabetes : the Atherosclerosis Risk in Communities Study?
Answer: Birth weight was not associated with diabetic retinopathy.
Output: | no | task846_pubmedqa_classification |
|
Teacher: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? If you are still confused, see the following example:
Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Reason: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Now, solve this instance: Question: Does daily weight-bearing activity increase the risk of diabetic foot ulcers?
Answer: Increased weight-bearing activity did not increase the risk of foot re-ulceration. Further studies are needed to explore weight-bearing activities that are safe for those with diabetes and insensate feet.
Student: | no | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Are factors associated with HIV infection the same for all women?
Answer: Factors vary in importance and significance of association with HIV infection in different subpopulations of women resident in Great Britain. This diversity is also likely to occur in other populations. It is important to identify these differences between subpopulations. Prevention and control policies and activities for HIV/AIDS cannot treat all women as if they were the same.
no
Question: Does dll1 haploinsufficiency in adult mice lead to a complex phenotype affecting metabolic and immunological processes?
Answer: In conclusion, slight alterations in one player of Notch signaling alter the entire organism, emphasizing the fine-tuning character of this pathway in a high number of processes.
yes
Question: Does ethanolic Ginkgo biloba leaf extract prevent renal fibrosis through Akt/mTOR signaling in diabetic nephropathy?
Answer: GbE can prevent renal fibrosis in rats with diabetic nephropathy, which is most likely to be associated with its abilities to inhibit the Akt/mTOR signaling pathway.
| yes
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Does the methionine-choline deficient dietary model of steatohepatitis exhibit insulin resistance?
Answer: GTT, ITT and QUICKI confirmed the absence of insulin resistance in the MCD fed mice. This model causes fibrosing steatohepatitis and may help delineate the non-insulin resistant mechanisms involved in human steatohepatitis.
A: no
****
Q: Question: Is neutrophil-lymphocyte ratio a reliable predictive marker for early-stage diabetic nephropathy?
Answer: Increased NLR was significantly associated with DN, and high NLR values may be a reliable predictive marker of early-stage DN.
A: yes
****
Q: Question: Stenosis carotid artery stenting in high risk patients with carotid artery eligible for endarterectomy : clinical outcome after 5 years?
Answer: This study confirms that stent procedures are beneficial for symptomatic carotid stenosis in patients not eligible for surgery.
A: | no
****
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[Q]: Question: Is time point important for effects of syngeneic bone marrow transplantation for type 1 diabetes in mice?
Answer: These results indicated that syn-BMT should be performed, when diabetes is neither too new-onset nor too late-stage. Tregs represent one mechanism for syn-BMT-induced restoration of immune tolerance in STZ-diabetic mice.
[A]: yes
[Q]: Question: Do associations of Heart Rate With Inflammatory Markers Are Modulated by Gender and Obesity in Older Adults?
Answer: Faster HR is associated with proinflammatory state in elderly patients; this association seems to be limited to women with higher BMI.
[A]: yes
[Q]: Question: Is genetic polymorphism in exon 2 of cathepsin D associated with vascular dementia?
Answer: The major genotype frequency at CTSD C224T in normal controls was higher in the Asian population than in various European populations. Our study does not show a significant difference in genotype (P=0.3071) and allele (P=0.2291) frequencies of CTSD C224T between VaD and normal controls. This was the first genetic association study of CTSD in a VaD population.
[A]: | no
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[Q]: Question: Does ataxia Severity correlate with White Matter Degeneration in Spinocerebellar Ataxia Type 7?
Answer: These results suggest a significant contribution of local cerebellar and cerebellar-midbrain connections to ataxic impairment in spinocerebellar ataxia type 7. The results also suggest an involvement of cortical WM abnormalities including tracts within the occipital and frontal cortices. These findings contribute to a more comprehensive view of the clinical impact of the white matter degeneration in spinocerebellar ataxia type 7.
[A]: yes
[Q]: Question: Does prescription consisting of Vitamin C and Baicalin inhibit tumor growth by enhancing the antioxidant capacity in vivo?
Answer: PVB shows better antitumor effect than Vc and baicalin used alone, and it can significantly enhance the immunity and antioxidant capacity of the mice.
[A]: yes
[Q]: Question: Does pPARγ activation affect endothelin activity in non-diabetic patients with hypertension or hypercholesterolemia?
Answer: In non-diabetic patients with hypertension or hypercholesterolemia, pioglitazone improves insulin sensitivity, lipid profile, and inflammation but does not affect endothelin activity. Our data suggest that the determinants of endothelin-1 vascular activity in vivo may differ and/or be more complex than those suggested by the results of previous in vitro studies.
[A]: | no
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example input: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Example output: yes
Example explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Q: Question: Does experimental diabetes mellitus type 1 increase hippocampal content of kynurenic acid in rats?
Answer: A novel factor potentially implicated in diabetic hippocampal dysfunction has been identified. Observed increase of KYNA level may stem from the activation of endogenous neuroprotection, however, it may also have negative impact on cognition.
A: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Example solution: yes
Example explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Problem: Question: Does pPARγ activation affect endothelin activity in non-diabetic patients with hypertension or hypercholesterolemia?
Answer: In non-diabetic patients with hypertension or hypercholesterolemia, pioglitazone improves insulin sensitivity, lipid profile, and inflammation but does not affect endothelin activity. Our data suggest that the determinants of endothelin-1 vascular activity in vivo may differ and/or be more complex than those suggested by the results of previous in vitro studies.
| Solution: no | task846_pubmedqa_classification |
|
Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Is aNGPTL2 associated with an increased risk of cardiovascular events and death in diabetic patients?
Answer: In patients with type 2 diabetes, serum ANGPTL2 concentrations were independently associated with death and MACE. Therefore, ANGPTL2 is a promising candidate biomarker for improving risk stratification in type 2 diabetes patients, and may prove to be a valuable therapeutic target.
Student: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Are elevated beta2-glycoprotein I-low-density lipoprotein levels associated with the presence of diabetic microvascular complications?
Answer: Elevated serum β2-GPI-LDL levels may be a serological hallmark of enhanced LDL oxidation in vivo and closely associated with the presence of diabetic microvascular complications. | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Does discovery-based protein expression profiling identify distinct subgroups and pathways in leiomyosarcomas?
Answer: These results suggest that UPS tumors share a similar lineage as leiomyosarcomas and are likely to originate from different stages of differentiation from mesenchymal stem cells to smooth muscle cells.
A: yes
****
Q: Question: Do novel meta-analysis-derived type 2 diabetes risk loci determine prediabetic phenotypes?
Answer: In contrast to the first series of GWA-derived type 2 diabetes candidate SNPs, we could not detect reliable associations of the novel risk loci with prediabetic phenotypes. Possible weak effects of ADAMTS9 SNP rs4607103 and VEGFA SNP rs9472138 on insulin sensitivity and insulin secretion, respectively, await further confirmation by larger studies.
A: no
****
Q: Question: Is total laparoscopic resection for advanced gastric cancer safe and feasible in the Western population?
Answer: Following total laparoscopic resection for advanced gastric cancer, oncologic endpoints, postoperative course, and early cancer-specific follow-up are excellent. The results demonstrated here support the routine use of these techniques in the Western patient population.
A: | yes
****
| task846_pubmedqa_classification |
|
Teacher: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? If you are still confused, see the following example:
Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Reason: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Now, solve this instance: Question: Does diabetes alter mortality or hemostatic and inflammatory responses in patients with severe sepsis?
Answer: Although diabetes is a risk factor for sepsis, once established, the outcome of severe sepsis does not appear to be significantly influenced by the presence of diabetes. In nondiabetic patients, however, admission hyperglycemia is associated with an increased mortality.
Student: | no | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[Q]: Question: Does vagus nerve stimulation have antidepressant effects in the kainic acid model for temporal lobe epilepsy?
Answer: The KA rats displayed anhedonia which was significantly decreased by VNS, indicating that this neuromodulatory treatment could likewise diminish depressive symptoms in patients suffering from temporal lobe epilepsy and comorbid depression.
[A]: yes
[Q]: Question: Do several mechanical manipulations of the wall of the inner ear affect air and bone conduction auditory thresholds?
Answer: It is likely that an alternative mode of cochlear excitation is possible.
[A]: no
[Q]: Question: Do serum miRNA biomarkers serve as a fingerprint for proliferative diabetic retinopathy?
Answer: These data provide evidence that serum miRNAs have the potential to be sensitive, cost-effective biomarkers for the early detection of PDR. These biomarkers could serve as a dynamic monitoring factor for detecting the progression of PDR from NPDR.
[A]: | yes
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does ethanolic Ginkgo biloba leaf extract prevent renal fibrosis through Akt/mTOR signaling in diabetic nephropathy?
Answer: GbE can prevent renal fibrosis in rats with diabetic nephropathy, which is most likely to be associated with its abilities to inhibit the Akt/mTOR signaling pathway. | yes | task846_pubmedqa_classification |
|
Given the task definition and input, reply with output. Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does inhibition of mitochondrial permeability transition pore restore the cardioprotection by postconditioning in diabetic hearts?
Answer: The loss of cardioprotection by IPostC in diabetic state can be overcome by increasing the potency of protective IPostC through its co-application with mPTP inhibition.
| yes | task846_pubmedqa_classification |
|
Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Problem:Question: Does losartan counteract the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats?
Answer: Aortas isolated from STZ-rats present hyper-contracture to AT-II mainly dependent on the up-regulation of ROCK1 expression/activity. In vivo losartan treatment partially corrects AT-II hyper-contracture, limiting the increase in ROCK1 expression/activity. These data offer a new molecular mechanism supporting the rationale for using losartan in the prevention of diabetic vascular complications.
Solution: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Ex Input:
Question: Does pharmacological preconditioning using intraportal infusion of L-arginine protect against hepatic ischemia reperfusion injury?
Answer: Pharmacological preconditioning with intraportal L-arginine provided protection against hepatic I/RI in early phases of the reperfusion period. The mechanisms underlying the protective effect may include preservation of the mitochondrial structure and inhibition of caspase-3 activity.
Ex Output:
yes
Ex Input:
Question: Does a protein complex containing Inscuteable and the Galpha-binding protein Pins orient asymmetric cell divisions in Drosophila?
Answer: Pins and Inscuteable are dependent on each other for asymmetric localisation in delaminated neuroblasts. The binding of Pins to Galpha protein offers the intriguing possibility that Inscuteable and Pins might orient asymmetric cell divisions by localising or locally modulating a heterotrimeric G-protein signalling cascade at the apical cell cortex.
Ex Output:
yes
Ex Input:
Question: Are myopia and/or longer axial length protective against diabetic retinopathy : a meta-analysis?
Answer: This meta-analysis suggests that both myopic refraction and longer AL are associated with a lower risk of DR. Further studies are needed to determine exact mechanisms underpinning the protective effect of myopia against DR.
Ex Output:
| yes
| task846_pubmedqa_classification |
|
instruction:
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
question:
Question: Is neutrophil-lymphocyte ratio a reliable predictive marker for early-stage diabetic nephropathy?
Answer: Increased NLR was significantly associated with DN, and high NLR values may be a reliable predictive marker of early-stage DN.
answer:
yes
question:
Question: Does growth hormone ( GH ) treatment restore endothelial function in children with GH deficiency?
Answer: These results indicate that endothelial function is impaired in children with GHD. GH therapy does not restore the impairment.
answer:
no
question:
Question: Does comorbidity influence multiple aspects of well-being of patients with ischemic heart disease?
Answer: This study showed a consistent pattern of associations between somatic comorbidities and multiple aspects of well-being among patients with IHD. Findings may increase cardiologists' interest to identify and treat somatic conditions among IHD patients.
answer:
| yes
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[Q]: Question: Do novel meta-analysis-derived type 2 diabetes risk loci determine prediabetic phenotypes?
Answer: In contrast to the first series of GWA-derived type 2 diabetes candidate SNPs, we could not detect reliable associations of the novel risk loci with prediabetic phenotypes. Possible weak effects of ADAMTS9 SNP rs4607103 and VEGFA SNP rs9472138 on insulin sensitivity and insulin secretion, respectively, await further confirmation by larger studies.
[A]: no
[Q]: Question: Are the Randomized Olmesartan and Diabetes Microalbuminuria Prevention ( ROADMAP ) observational follow-up study : benefits of RAS blockade with olmesartan treatment sustained after study discontinuation?
Answer: Development of microalbuminuria is a valid marker for future CV events. RAS blockade with Olmesartan might cause sustained reduction (legacy effect) of micro- and macrovascular events.
[A]: yes
[Q]: Question: Does early cleavage predict treatment outcome following the use of GnRH antagonists in women older than 35?
Answer: In women older than 35 years, the early-cleavage rate of zygotes is significantly lower in the GnRH antagonist group than the agonist group. Early-cleavage status of zygotes is not a reliable predictor for embryo implantation in patients receiving the GnRH antagonist protocol.
[A]: | no
| task846_pubmedqa_classification |
|
TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Are intrafollicular interleukin-8 , interleukin-12 , and adrenomedullin the promising prognostic markers of oocyte and embryo quality in women with endometriosis?
Answer: The levels of IL-8, IL-12, and adrenomedullin may be good indicators of embryo and oocyte quality in endometriosis patients undergoing IVF. Further studies are necessary to ascertain the potential of these markers for oocyte and embryo developmental competence which may help improve the chances of a successful IVF in endometriosis patients.
SOLUTION: yes
PROBLEM: Question: Does co-Transplantation of Skin-Derived Precursors and Collagen Sponge facilitate Diabetic Wound Healing by Promoting Local Vascular Regeneration?
Answer: Accelerated wound healing and enhanced local capillary regeneration could be observed 14 days after skin ablation from both SKPs and collagen sponge co-transplanted and collagen sponge only groups. Subsequent analyses further revealed superior pro-angiogenic effects from the SKP and collagen sponge co-delivered group, which are mainly attributable to in vivo transdifferentation and paracrine signalling of the SKPs.
SOLUTION: yes
PROBLEM: Question: Is dietary counseling associated with an improved lipid profile in children with familial hypercholesterolemia?
Answer: FH children had a higher intake of SFA than recommended and the SFA intake was positively correlated with plasma TC, LDL-C and apo B levels in FH children not using statins. Importantly, the plasma lipid profile was improved in FH children after dietary counseling where focus was on reducing intake of SFA and dietary cholesterol.
SOLUTION: | yes
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example input: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Example output: yes
Example explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Q: Question: Is severity of hearing impairment positively associated with urine albumin excretion rate in patients with type 2 diabetes?
Answer: The present study showed increased albuminuria was positively associated with the severity of hearing impairment among patients with type 2 diabetes. Screening for hearing impairment in diabetic patients who develop albuminuria might provide early detection of hearing impairment.
A: | yes | task846_pubmedqa_classification |
|
Q: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Is renal pathological change in patients with type 2 diabetes always diabetic nephropathy : a report of 52 cases?
Answer: NDRD was a common feature in Type 2-diabetic patients with renal involvement. The absence of retinopathy and short periods of diabetic history may be useful indicators for diagnosis of NDRD clinically.
A: | no | task846_pubmedqa_classification |
|
instruction:
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
question:
Question: Is the absolute nucleated red blood cell ( aNRBC ) count at birth an indicator for retinopathy of prematurity ( ROP )?
Answer: We are unable to support the previously reported relationship of aNRBCs with ROP. Our population was three times larger, had higher aNRBCs and less retinopathy than previously reported. A biological principle of cause and effect or predisposition to ROP as reflected by aNRBCs should have been easier for us to demonstrate, if it existed.
answer:
no
question:
Question: Does co-Transplantation of Skin-Derived Precursors and Collagen Sponge facilitate Diabetic Wound Healing by Promoting Local Vascular Regeneration?
Answer: Accelerated wound healing and enhanced local capillary regeneration could be observed 14 days after skin ablation from both SKPs and collagen sponge co-transplanted and collagen sponge only groups. Subsequent analyses further revealed superior pro-angiogenic effects from the SKP and collagen sponge co-delivered group, which are mainly attributable to in vivo transdifferentation and paracrine signalling of the SKPs.
answer:
yes
question:
Question: Are fibular axes a reliable landmark for tibial mechanical axes of osteoarthritic knees that underwent total knee arthroplasty?
Answer: The angle between the tibial mechanical and fibular shaft axes differed among patients, independent of patient-specific factors, and did not appear to be a reliable intra-operative landmark. Surgeons should use values from individual pre-operative evaluations of the axis as reference for conventional TKA.
answer:
| no
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Consider Input: Question: Does proper timing of adjuvant chemotherapy affect survival in patients with stage 2 and 3 gastric cancer?
Answer: There is insufficient evidence to suggest starting adjuvant chemotherapy within 4 weeks after surgery for patients with D2 resected stage 2 and 3 gastric cancer. However, delayed treatment of adjuvant chemotherapy after 8 weeks showed worse survival outcomes than early and intermediate treatment initiation, suggesting that adjuvant chemotherapy should be considered start within 8 weeks after radical resection.
Output: yes
Input: Consider Input: Question: Is time point important for effects of syngeneic bone marrow transplantation for type 1 diabetes in mice?
Answer: These results indicated that syn-BMT should be performed, when diabetes is neither too new-onset nor too late-stage. Tregs represent one mechanism for syn-BMT-induced restoration of immune tolerance in STZ-diabetic mice.
Output: yes
Input: Consider Input: Question: Does truncation in the tcdC region of the Clostridium difficile PathLoc of clinical isolates predict increased biological activity of Toxin B or Toxin A?
Answer: Our data do not support a direct role for alterations in the tcdC gene as a predictor of hyperproduction of Toxin A and B in NAP1-related strains.
| Output: no
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Does co-Transplantation of Skin-Derived Precursors and Collagen Sponge facilitate Diabetic Wound Healing by Promoting Local Vascular Regeneration?
Answer: Accelerated wound healing and enhanced local capillary regeneration could be observed 14 days after skin ablation from both SKPs and collagen sponge co-transplanted and collagen sponge only groups. Subsequent analyses further revealed superior pro-angiogenic effects from the SKP and collagen sponge co-delivered group, which are mainly attributable to in vivo transdifferentation and paracrine signalling of the SKPs.
A: yes
****
Q: Question: Do changes in basophil activation during grass-pollen sublingual immunotherapy correlate with clinical efficacy?
Answer: Allergen reactivity of peripheral blood basophils is not a biomarker for adverse events or early onset of clinical responses to SLIT.
A: no
****
Q: Question: Does mechanical pleurodesis reduce recurrence of spontaneous pneumothorax : a randomized trial?
Answer: Thoracoscopic mechanical pleurodesis did not significantly decrease primary spontaneous pneumothorax recurrence compared with simple wedge resection, but intraoperative bleeding and postoperative pleural drainage rates were higher. Younger age increases the risk of recurrence.
A: | no
****
| task846_pubmedqa_classification |
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