Study_ID
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CRD42023488855 | Are video games an efficacious intervention for cognitive impairment associated with schizophrenia (CIAS) and how do they compare with cognitive remediation? | Cognitive impairment associated with schizophrenia (CIAS). | null |
CRD42025648992 | Primary Question:
What is the effectiveness of deprescribing protocols in reducing adverse drug reactions among older adults with polypharmacy?
Secondary Questions:
How do different deprescribing strategies (e.g., pharmacist-led, physician-guided, technology-assisted) compare in their effectiveness?
What impact do deprescribing interventions have on medication burden, healthcare utilization, and quality of life in older adults?
How does the effectiveness of deprescribing protocols vary across different healthcare settings (e.g., primary care, hospital, long-term care)?
What patient-related and system-related factors influence the successful implementation of deprescribing strategies in older adults?
PIECOS Framework Application
Population (P): Older adults (≥65 years) with polypharmacy (≥5 medications).
Intervention (I): Deprescribing protocols (structured medication review and reduction strategies).
Exposure (E): Multiple medication use and associated adverse drug reactions.
Comparator (C): Usual care (no structured deprescribing) or alternative deprescribing strategies.
Outcomes (O): Reduction in adverse drug reactions (primary), medication burden, healthcare utilization, quality of life (secondary).
Study Design (S): Randomized controlled trials, cohort studies, and other relevant observational studies.
This structured approach ensures clarity in defining the scope of the review while addressing specific aspects of deprescribing in older adults. | Polypharmacy is a significant concern in geriatric healthcare, defined as the concurrent use of multiple medications, often leading to adverse drug reactions (ADRs), increased risk of falls, cognitive decline, hospitalizations, and overall diminished quality of life. The complexity of managing multiple medications in older adults, particularly those with comorbidities, necessitates deprescribing— a structured process of medication review and withdrawal when benefits no longer outweigh risks. Deprescribing protocols, which may be physician-guided, pharmacist-led, or technology-supported, aim to reduce inappropriate medication use while maintaining patient safety and therapeutic efficacy. This systematic review focuses on evaluating the effectiveness of deprescribing interventions in reducing ADRs and improving health outcomes in older adults, contributing to the optimization of medication management in primary care and geriatric settings. | null |
CRD420251003850 | This thesis aims to clarify the holistic impact of structured exercise programs (intradialytic, home-based, or hybrid) in adults with chronic kidney disease (CKD), whether dialyzed or non-dialyzed. By comparing these interventions to standard care, we evaluate their efficacy across three key domains: | Adults (≥18 years) with chronic kidney disease (CKD) stages 3–5 per KDIGO classification. Patients on dialysis (hemodialysis [HD] or peritoneal dialysis [PD]) or non-dialyzed. Interventions Structured Exercise Programs: Intradialytic (during HD), home-based, or combined. Study Design Study Types: Randomized controlled trials (RCTs), meta-analyses, systematic reviews. Languages: French or English. Publication Period: 2010–2023 (to reflect recent evidence). Home Exercise Program; Exercise therapy; Muscle Strength Exercise Types of Interventions A. Intradialytic Exercise Setting: Conducted during hemodialysis (HD) sessions to utilize time effectively and counteract sedentariness. Components: Resistance Training: Elastic bands, light weights (30–50% 1RM), leg extensions. Aerobic Exercise: Stationary cycling or pedaling (50–60% max heart rate). Safety: Continuous monitoring of blood pressure and oxygen saturation. B. Home-Based Exercise Setting: Supervised remotely via tele-rehabilitation platforms (apps, video calls). Components: Aerobic: Brisk walking, seated marching. Resistance: Bodyweight exercises (chair squats, wall push-ups). Flexibility: Stretching routines for major muscle groups. Adherence: Tracked via digital logs or wearable devices. C. Hybrid Program Combination: Integrates intradialytic + home-based protocols for synergistic effects. PICO tags selected: Usual Care | Population Severe Comorbidities: Contraindications to exercise (e.g., unstable angina, decompensated heart failure, recent fractures, or uncontrolled hypertension). Severe cognitive impairment (inability to provide informed consent or follow exercise protocols). Terminal illnesses or life expectancy < 6 months. Populations: Pediatric patients (<18 years). Non-CKD populations (e.g., acute kidney injury, transplant recipients). Patients enrolled in other concurrent rehabilitation or exercise programs (to avoid confounding effects). Study Types Non-RCT Designs: Observational studies, case reports, editorials, or non-peer-reviewed literature. Studies lacking a control group (standard care). Incomplete Data: Studies failing to report primary outcomes (functional performance, quality of life, serum albumin). Non-stratified results (e.g., no separation by CKD stage or dialysis modality). Other Exclusions Studies published before 2010 or in languages other than French/English. Duplicate publications or secondary analyses without original data. |
CRD42024497822 | Does 5-Nitroimidazole derivatives reduce the parasitic load in animal models of parasitic neglected tropical diseases? | Neglected Tropical Diseases; Chagas Diseases; Leishmaniasis; Malaria All animal models with experimental parasitic neglected tropical diseases. 5-nitroimidazole derivatives treatment. All timings, frequencies and dosages of treatment are eligible for inclusion. We will include randomised controlled trials of pharmaceutical treatment of neglected tropical diseases where two or more drugs are compared, or where one drug is compared to placebo or no treatment. | Animals with co-morbilities; ex vivo, in vitro and in silico models. Treatments with non-5 nitroimidazole derivatives. Studies without a separate control group. |
CRD42020203927 | How does yoga as a therapeutic means affect prehypertension and hypertension in adults compared to usual care or other interventions? | Hypertension. Prehypertension. Yoga in adults. | null |
CRD42024503722 | The aim of this network meta-analysis is to evaluate the intervention effects of three kinds of Traditional Chinese Fitness Exercises in Patients with Parkinson’s disease. | Condition or domain being studied: Parkinson's disease is the second most common neurodegenerative disease, which tends to occur in middle-aged and elderly people, with an incidence of more than 1% over the age of 60. The clinical symptoms of Parkinson's disease include motor symptoms and non-motor symptoms. Among them, the motor symptoms include static tremor, muscle rigidity, slow movement and postural balance disorder.In recent years, the research on the intervention of Parkinson's disease by traditional Chinese health methods has increased, such as Taijiquan, Baduanjin and Wuqinxi.
However, most of the current clinical studies are only studies on the therapeutic effect of a single traditional fitness method on Parkinson's disease, and there are few evidence-based evaluations comparing the clinical efficacy and safety of multiple fitness exercises in the intervention treatment of Parkinson's disease. Therefore, the purpose of this study is to select several traditional fitness exercises commonly used in clinical practice as the research object, use the network meta-analysis method to quantitatively compare the intervention effects of different fitness exercises, and rank the advantages and disadvantages, and select the traditional fitnessexercises with the best intervention effects. | null |
CRD42024572804 | What is the efficacy of Transcranial Magnetic Stimulation (TMS) as a therapeutic Intervention for post- traumatic stress disorder (PTSD) in Adults? | Post-traumatic stress disorder (PTSD), previously known as battle fatigue syndrome or shell shock , is a severe mental disturbance condition that is normally triggered by the experience of some frightening/scary events or trauma where a person undergoes some serious physical or mental harm or threatened. PTSD is a long-life effect of the continuous occurrence of traumatic conditions, leading to the production of feelings of helplessness, intense fear, and horror in the person[1].Post-traumatic stress disorder (PTSD) is the only major mental disorder for which a cause is considered to be known: that is, an event that involves threat to the physical integrity of oneself or others and induces a response of intense fear, helplessness or horror[2].
1.Thakur A, Choudhary D, Kumar B, Chaudhary A. A Review on Post-traumatic Stress Disorder (PTSD): Symptoms, Therapies and Recent Case Studies. Curr Mol Pharmacol. 2022;15(3):502-516. doi: 10.2174/1874467214666210525160944. PMID: 34036925.
2.Pitman RK, Rasmusson AM, Koenen KC, Shin LM, Orr SP, Gilbertson MW, Milad MR, Liberzon I. Biological studies of post-traumatic stress disorder. Nat Rev Neurosci. 2012 Nov;13(11):769-87. doi: 10.1038/nrn3339. Epub 2012 Oct 10. PMID: 23047775; PMCID: PMC4951157.
. | null |
CRD42024541967 | Which non-pharmacological interventions are effective in preventing or managing paediatric delirium in critical care? | Delirium is relatively common in paediatric intensive care, reportedly affecting at least 1 in 3 children. However, detecting paediatric delirium (PD) can be complex. Understanding facets of presentation, risk factors, screening, and the ability to differentiate it from behaviours complicated by critical illness burden and developmental stage are vital. Characterized by disrupted cerebral functioning, PD manifests in critical care with rapid-onset disturbances in attention, cognition, and behaviour. Presentation may include disorientation, reduced awareness of the environment, impaired attention, problems with short-term memory, language and information processing, sleep dysregulation, and the experience of hallucinations or delusions, which can be stressful and frightening for children and their families and difficult to manage for healthcare staff. Risk factors for PD include severity of critical illness, under 2 years of age, mechanical ventilation, developmental delay, and administration of medications such as benzodiazepines and anticholinergics. While PD often resolves, long-term outcomes following critical care admission are underreported. Adverse effects may extend beyond critical care to impact cognition and cause stress for children and families. Effective pharmacological treatments are lacking, driving interest in non-pharmacological interventions to mitigate delirium risk and associated complications, such as those targeting mechanical ventilation, sedation, mobility, family involvement, and sleep quality. | null |
CRD420250650645 | This meta-analysis evaluated the efficacy of negative symptoms and treatment acceptability as primary outcomes while assessing the severity of positive symptoms and overall psychiatric symptoms as secondary outcomes. | Schizophrenia; Intermittent theta burst stimulation Schizophrenia (SCZ) is a chronic, severe, and debilitating mental disorder, with a lifetime prevalence rate of approximately 0.7% in China. Negative symptoms are a core feature of schizophrenia, affecting 40-60% of patients.Compared to positive symptoms, patients with more pronounced negative symptoms tend to experience poorer functional outcomes, which are closely linked to impairments in occupational, familial, and recreational activities, as well as challenges in interpersonal relationships. While positive symptoms can generally be effectively managed with antipsychotic medications, treatment options for negative symptoms remain limited and often less effective. recruitment of participants diagnosed with schizophrenia and assessment of negative symptoms in schizophrenia patients. studies involving the application of Intermittent Theta Burst Stimulation (iTBS) Sham Control | null |
CRD420250655343 | Does the use of probiotics and synbiotics reduce gastrointestinal symptoms and improve the quality of life in patients with IBS-C? | Irritable Bowel Syndrome with Constipation (IBS-C) is a gastrointestinal disorder characterized by chronic abdominal pain or discomfort associated with altered bowel habits, specifically constipation. Patients with this condition often experience infrequent, hard, or lumpy stools, straining during defecation, and a sensation of incomplete evacuation, frequently accompanied by bloating. The exact etiology of IBS-C is not fully understood, but it is believed to involve a combination of factors, including impaired colonic motility, visceral hypersensitivity, gut microbiota alterations, and psychological stress. IBS-C significantly affects the quality of life, leading to distress and disruption of daily activities. Effective management often includes dietary modifications, fiber supplementation, and probiotics to alleviate symptoms and improve patient well-being. The participants in this review will include adults aged 18 years or older who have a clinical diagnosis of constipation-predominant irritable bowel syndrome (IBS-C), based on the Rome III or Rome IV criteria. There will be no restrictions regarding sex or ethnicity. Exclusion criteria will include patients with other subtypes of irritable bowel syndrome (such as diarrhea-predominant IBS or mixed-type IBS), as well as those with other gastrointestinal diseases, including inflammatory bowel disease (IBD), celiac disease, or other known gastrointestinal disorders The intervention used in this review will be the use of probiotics and synbiotics, including bacterial and fungal strains, in various concentrations. PICO tags selected: Probiotics; Pain Relief; Assessment Of Quality Of Life The comparator used in this review will be placebo. | null |
CRD42024588059 | What is the efficacy and safety of Janus kinase (JAK) inhibitors in the treatment of IgG4-related disease (IgG4-RD) across diverse organ involvement and disease presentations? | IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory disorder characterized by lymphoplasmacytic infiltration of IgG4-positive plasma cells and storiform fibrosis in multiple organs. Current treatment primarily involves glucocorticoids and immunosuppressive agents; however, long-term use of these therapies carries significant side effects.
Janus kinase (JAK) inhibitors have emerged as a potential treatment for IgG4-RD due to their role in modulating key inflammatory pathways. Several studies, including case reports, cohort studies, and small trials, have explored the efficacy and safety of JAK inhibitors like tofacitinib, baricitinib, ruxolitinib, and upadacitinib in IgG4-RD. This systematic review aims to synthesize the evidence to determine their therapeutic potential and safety profile in this disease. | null |
CRD420250598206 | The purpose of this study was to assess Yuejuwan (YJW) as a Chinese medicine formula for animal models of depression in rodents.Population (P): Animal models of depression in rodentsanimal Intervention (I): Yuejuwan Comparison (C): Randomized controlled experimentOutcomes (O): Behavioral changes | Depression. All animals regardless of species, strains, age and sex. Yuejuwan (YJW), or YJW plus western medicine. | Non-animal studies or with co-morbidities. No Yuejuwan (YJW) treatment , No YJW plus western medicine treatment. Control animals went under effective (no-sham) surgery. |
CRD420251001904 | Is the effect and safety of Fu's Subcutaneous Needling better than that of acupuncture for patients with lumbar intervertebral disc protrusion? | Patients with Lumbar Disc Herniation. There is no restriction on age, gender, race, etc. No NO Randomized controlled trial of Fu's Subcutaneous Needling for lumbar disc herniation. Publication time is not restricted by country. Language is limited to Chinese and English. | Not patients with Lumbar Disc Herniation. The experimental group did not use Fu's Subcutaneous Needling, or the Fu's Subcutaneous Needling were not used in the control group. The control group cannot use Fu's Subcutaneous Needling, or combine two or more intervention measures. Other languages. Publishing duplicate studies. |
CRD42024595642 | "What is the potential effect of the compound 2-AEH2F on controlling cancer progression?"
PICO
(P) target population comprises individuals diagnosed with cancer.
(I) intervention refers to the administration of the compound 2-AEH2F.
(C) comparative, people undergoing conventional treatment will be considered.
(O) Expected results, the reduction of side effects associated with conventional treatment and its impact on cancer progression. | Cancer is a complex and multifactorial disease characterized by abnormal cell growth and spread. This process is governed by a series of genetic and epigenetic alterations that lead to dysfunction of the normal mechanisms controlling cell growth and death. The pathophysiology of cancer involves a series of events that occur at the cellular and molecular level. 2-AEH2F has been investigated in cancer control due to its diverse mechanisms of action that suggest it as a potential therapeutic adjuvant, one of these mechanisms is its ability to inhibit cell proliferation. | null |
CRD420250655838 | 1. How effective is footwear as a management strategy for people with inflammatory arthritis (IA)? 2. How effective is footwear as a management strategy for people with connective tissue disorders (CTDs)? | The conditions that are being studied in this systematic review will be inflammatory arthritis and connective tissue disorders. Inflammatory arthritis encompasses many forms of arthritis including, rheumatoid arthritis, spondyloarthropathies and osteoarthritis which are all chronic inflammatory joint diseases. An individual who presents with these typically experiences pain, stiffness, joint swelling and progressive joint damage. Additionally, connective tissue disorders such as systemic lupus erythematosus (SLE) and systemic sclerosis (scleroderma) are autoimmune diseases which affect connective tissues leading to impaired mobility, joint deformities, vascular complications and systemic inflammation. These conditions can impact activities of daily living (ADLs), mobility and quality of life, reinforcing the importance of the review to assist in understanding the efficacy of footwear as a management strategy to alleviate symptoms, enhance functional outcomes and improve mobility for individuals living with these conditions. Inclusion Criteria: - The systematic review will include the adult population only, so participants will be 18 years and over and have a working diagnosis of IA or CTD.Exclusion Criteria:- Studies not originally in English or not translated into English due to the primary language of the research team, despite participants being over 18.- The systematic review will not include studies with individuals under 18 years of age. The intervention that will be reviewed in the systematic review is footwear as a management strategy for inflammatory arthritis and connective tissue disorders. This includes any type of therapeutic or non-therapeutic footwear and assesses its effectiveness of managing the symptoms of these conditions.Inclusion criteria:Any type of therapeutic or nontherapeutic footwear that is used as a management strategy for these conditions. Not Applicable | null |
CRD42018093507 | What are the effects of computerized clinical decision support systems (CDSS) for the prescribing of oral anticoagulant therapy, compared to routine care? Which CDSS characteristics or implementation features are associated with success vs. failure? | Prescription of oral anticoagulants | null |
CRD420250639065 | "What is the efficacy and safety of bioactive molecules derived from amphibian venoms in the treatment of cancer, compared to conventional treatments or no treatment, in in vitro and in vivo models?" | It's being modelled a revision about burn peptides of the dermaseptin class and their therapeutic use in cancer treatment In vivo murine and lagomorph models of treatment of any type of cancer presented in the studies found*Rats (Wistar; Balc; Sprague-Dawley);within our search strategy, previous screenings will be considered in the analysis, such as:*Mice;*Rabbits;In vitro experiments with cells. Interventions must be related to the cause of cancer in animals and cells. | Any other type of animal; not using a cancer treatment model Any other type of intervention that has not contributed to treating cancer in animals and cells. It was not compared with treatments that used non-dermaseptin and chemotherapeutic-based models. |
CRD420250619643 | What are the efficacy and safety of the different androgen receptor signaling inhibitors (ARSIs) in metastatic hormone-sensitive prostate cancer (mHSPC), including subgroup analyses for patients with high tumor volume? | Prostate Cancer; Hormone Therapy; Efficacy; Safety The disease domain being studied in this systematic review and meta-analysis is the treatment of metastatic hormone-sensitive prostate cancer(mHSPC), defined as advanced prostate cancer that has not received hormone therapy. Prostate cancer was the most commonly diagnosed cancer in meal and there were 268 thousand new cases and 35 thousand deaths of prostate cancer in the United States in 2022. In the past few years, serval large, randomized, phase 3 clinical trials have show that the overall survival (OS), radiographic progression-free survival (rPFS) and median time to prostate-specific antigen (PSA) progression were longer among the patients received androgen receptor signaling inhibitors with ADT or ADT alone. Nevertheless, the efficacy and safety of androgen receptor signaling inhibitors plus ADT for mHSPC have not yet been compared. In this study, we aim to comprehensively understand the therapeutic effects and safety profile of androgen receptor signaling inhibitors in prostate cancer patients, providing a reliable evidence base for clinical practice. The studies that met the criteria below were included: (1) the article was relevant to androgen receptor signaling inhibitors or androgen biosynthesis inhibitor plus androgen deprivation therapy in patients with mHSPC; (2) the study was randomized, phase three clinical trials; (3) a head-to-head comparison of the efficacy and safety of two therapy was performed. Enzalutamide; Bicalutamide; Apalutamide; Darolutamide; Abiraterone Acetate Combination therapy was the main intervention.(e.g.enzalutamide plus androgen deprivation therapy , bicalutamide plus androgen deprivation therapy, apalutamide plus androgen deprivation therapy, darolutamide plus androgen deprivation therapy, rezvilutamide plus androgen deprivation therapy, abiraterone acetate and prednisone plus androgen deprivation therapy) PICO tags selected: Placebo Placebo plus androgen deprivation therapy. | The article would be excluded if it met the following criteria:(1) duplicative; (2) the irrelevant to mHSPC; (3) the publishment was not in English; (4) the data was not extractable in the article. (5)animal experiments. |
CRD42024564954 | What is the impact of palliative care delivered through overnight U.S. summer camps (intervention), compared to either no specific intervention or standard palliative practice, on quality of life (outcome) of caregivers of young people aged 7 up to 18 with serious or chronic illness (population)?" | Children and adolescents face a variety of serious and chronic illnesses and conditions. Parents/caregivers of children with serious and chronic illnesses face significant risks including high rates of self-harm, depression, and anxiety. Evidence suggests that Out of School Time (OST), like summer camps, can serve as a specialized therapeutic care (i.e., palliative) intervention for youth living with chronic or serious illness and their parents/caregivers. Parents and caregivers who involve their children in OST experiences do so for a variety of reasons, including (child and parent) respite. While there is considerable literature supporting the benefits of camp for both children with chronic illness and their caregivers, there is little research evaluating the use of OST settings as a direct palliative care intervention for caregivers. | null |
CRD42024616858 | Population
Inclusion:
Patients diagnosed with intracranial hypertension due to:
Traumatic brain injury (TBI)
Spontaneous intracerebral hemorrhage (ICH)
Exclusion:
Patients with pre-existing conditions impacting intracranial pressure (e.g., hydrocephalus unrelated to TBI/ICH, brain tumors)
Patients with contraindications to hyperosmolar therapy
Intervention: 23.4% hypertonic saline
Comparator(s): 3% hypertonic saline & 20% mannitol
Outcomes
Primary Outcomes:
Reduction in intracranial pressure (ICP)
Neurological outcomes (e.g., Glasgow Coma Scale improvement, modified Rankin Scale scores)
Secondary Outcomes:
Mortality rates
Complications or adverse effects (e.g., electrolyte imbalance, renal dysfunction)
Length of ICU/hospital stay
Study Design
Inclusion:
Randomized controlled trials (RCTs)
Observational studies (e.g., cohort or case-control studies with robust methods)
Exclusion:
Case reports, review articles, editorials, and conference abstracts without sufficient data | This review focuses on intracranial hypertension, a critical condition characterized by elevated intracranial pressure (ICP) that can result from traumatic brain injury (TBI) or spontaneous intracerebral hemorrhage (ICH). Effective management of elevated ICP is vital to prevent secondary brain injury, improve neurological outcomes, and reduce mortality. The study examines the comparative efficacy and safety of three hyperosmolar therapies: 23.4% hypertonic saline, 3% hypertonic saline. | null |
CRD420250643041 | 1. What tinnitus-related clinical practice guidelines have been published in the last 10 years?2. What are the key recommendations provided by these guidelines regarding the diagnosis and treatment of subjective tinnitus?3. How were these guidelines developed, including their methodological rigor, evidence bases, and stakeholder involvement?4. What are the similarities and differences among these guidelines in terms of recommendations and quality?5. What are the potential gaps in the existing guidelines that need to be addressed in future guideline development? | Subjective tinnitus impacts a substantial global population, reducing quality of life for millions, yet current clinical guidelines exhibit inconsistent quality and methodological rigor, contributing to heterogeneous practices and suboptimal outcomes. Key challenges persist in its management: etiological complexity due to interactions between auditory pathway dysfunction, neural plasticity, and psychological comorbidities complicates targeted interventions; diagnostic reliance on subjective reports lacks objective biomarkers, limiting standardized assessment; and therapeutic strategies, including sound therapy and cognitive-behavioral interventions, demonstrate variable efficacy and adherence, while emerging neuromodulation approaches require further evidence-based validation. A rigorous evaluation of guidelines is critical to address these gaps, harmonize methodological standards, and improve patient-centered care frameworks. Adults with subjective tinnitus. In the absence of corresponding sound sources and electrical (magnetic) stimulation sources in the surrounding environment, patients have a subjective sensation that there is sound in their ears or inside their skulls, and the course of the disease lasts for more than three months. Details of interventions recommended in the clinical guidelines will be recorded. | null |
CRD42025637038 | What role do epigenetic modifications play in immune response and tissue healing in apical periodontitis ? | Apical Periodontitis | null |
CRD420251000404 | Does curcumin supplementation improve motor symptoms in PD patients? | Adults with Parkinson's disease (as diagnosed using any recognised diagnostic criteria). Patients on stable doses of dopaminergic medications. Curcumin; Nanocurcumin Curcumin Formulations: Studies using various curcumin formulations, such as: Nanomicelle curcumin, Curcumin phospholipids, CurQfen, Encapsulated curcumin crystalline powder. Administration Route: Oral administration of curcumin Co-interventions: Studies where participants continue their prescribed drug regimen for PD, with curcumin as an add-on therapy. PICO tags selected: Placebo; Usual Care The systematic review will include randomized controlled trials (RCTs) and cohort study that assess the efficacy of curcumin or its formulations as a therapeutic intervention for Parkinson's Disease | Patients with Parkinson's disease due to atypical parkinsonism, or secondary causes. Patients with severe systemic or psychological diseases. Non-curcumin Interventions: Studies that do not specifically assess the effects of curcumin or its formulations. Non-oral administration: Studies using non-oral routes of curcumin administration. Incomplete Data: Studies that do not provide sufficient details regarding the curcumin formulation, dosage, or duration of treatment. Studies not reporting original data (e.g., reviews, editorials, and case reports) and those with incomplete data or methodological flaws will not be included. Studies involving animal models or in vitro experiments will also be excluded. |
CRD420250646398 | In patients with Parkinson's Disease, what is the therapeutic effect of N-acetylcysteine and Glutathione supplementation on motor and non-motor symptoms, disease markers , and disease progression, based on randomized controlled trials? | Parkinson's Disease Patients (18+ years) diagnosed with Parkinson's disease (early, moderate, or advanced stages). Human participants only. Glutathione; N-acetyl cysteine Our intervention focuses on assessing the improvement in Parkinson's disease patients across a range of outcomes following NAC and/or glutathione administration. These outcomes include clinical measures related to motor symptoms (e.g., tremor, rigidity, bradykinesia), non-motor symptoms (e.g., cognitive impairment, mood disorders, depression), disease progression (e.g., delay in motor deterioration, reduction in motor fluctuations), relevant biomarkers (e.g., oxidative stress markers, glutathione levels), and quality of life improvements related to Parkinson's disease. We will also consider data from any symptomatic assessment tools, such as the Unified Parkinson's Disease Rating Scale (UPDRS). The NAC and/or glutathione interventions can be administered in various ways, including orally (capsules, tablets, liquids), intravenously (infusion), intramuscularly (injection), inhaled (nebulizer), transdermally (patch), or topically (cream, gel). PICO tags selected: Placebo; Usual Care Comparators will include placebo, with or without standard Parkinson's disease (PD) care. Studies employing other active comparators will also be considered. Standard PD care will be defined as the treatments and management strategies commonly used for PD at the time the eligible studies were conducted. | Studies involving populations with neurodegenerative diseases which are not Parkinson's Disease (e.g., Alzheimer's, Huntington's disease). Non-human studies (e.g., rodent models, animal studies). Studies where N-acetylcysteine or Glutathione is not the primary treatment or is combined with unrelated therapies. |
CRD420251013394 | We intend to evaluate the effects of testosterone replacement therapy on vascular function (FMD, IMT), glycemic control (FPG, HbA1c, HOMA-IR), metabolic syndrome, lipid profile, anthropometric parameters (BMI, non-HDL cholesterol),testosterone levels, and quality of life (AMS questionnaire). | Adult men (≥18 years old) with OR WITHOUT described obesity Men with Type-two diabetes mellitus Testosterone replacement therapy (TRT) in any form (e.g., injectable, transdermal, oral) Hormone Replacement Therapy; Testosterone PICO tags selected: Placebo No testosterone replacement therapy Randomized clinical trials, cohort studies, case-control studies, cross-sectional studies, diagnostic studies, observational studies. | Patients with primary testicular failure (e.g., Klinefelter syndrome) where Testosterone Replacement Therapy is not comparable to secondary hypogonadism. Men receiving Testosterone replacement therapy for non-medical purposes (e.g., bodybuilding, anti-aging). Studies where Testosterone Replacement Therapy is combined with other hormonal therapies (e.g., growth hormone, anabolic steroids). Narrative reviews, case reports, editorials, expert opinions, and letters to the editor. |
CRD42025641717 | Metabolic-associated fatty liver disease (MASLD) affects 38% of the global population and is increasingly prevalent among younger individuals. It has now become the leading cause of chronic liver disease worldwide. The economic and societal burdens associated with MASLD are substantial. Moreover, if left untreated, MASLD can progress to severe clinical outcomes such as cirrhosis and hepatocellular carcinoma (HCC). Current evidence suggests that genetic factors, environmental influences, and lifestyle choices all contribute to the development and progression of MASLD. Exercise interventions have been identified as a crucial therapeutic measure, capable of improving various clinical indicators such as lipid metabolism, hepatic fibrosis, and insulin resistance. However, patient adherence to exercise interventions in clinical practice remains low. Therefore, identifying the most effective type of exercise intervention for improving MASLD is of significant value, as it can provide a theoretical basis for clinical practice. | Clinical practice has demonstrated that exercise interventions are an effective approach for influencing MASLD. If individuals maintain more than 60 minutes of vigorous physical activity per week, the likelihood of developing MASLD can be reduced by 42%. However, previous research findings have shown conflicting results regarding the impact of different exercise modalities on patients. Some studies suggest that aerobic exercise and resistance training have comparable abilities to improve patient outcomes. Moreover, in a large-sample randomized controlled trial (RCT), patients were further assigned to moderate- or high-intensity groups, and the results indicated that the effects of different training intensities on liver enzyme indices were not statistically significant. Therefore, although exercise interventions hold potential value in the management of MASLD, the current research findings remain inconsistent and limited. From the existing studies, there is a lack of direct comparisons among different pieces of evidence, and further exploration is needed. | null |
CRD420250570146 | Objectif principal : Décrire les expérimentations de soins pharmaceutiques développées dans la prise en charge des maladies chroniques dans les PRFI | Chronic Disease; Patient Education Adult patient with a chronic disease Education; Medication Review Done By Pharmacist; Pharmaceutical services | null |
CRD420250638727 | What are the therapeutic effects of footbath on the physical and psychological outcomes of stroke patients? | To explore scientific evidence regarding the effects of footbath on the physical and psychological aspects of stroke patients Stroke patients aged 18 years and older footbath standard care and health group | null |
CRD42023394214 | The specific review questions addressed in this review are:
1. What is the relationship between adherence and swallowing efficacy in adults with head and neck cancer (HNC)?
2. To what extent do factors influence exercise adherence variability, including intervention characteristics type i.e., direct intervention approach (diet modifications) versus indirect intervention approach (postural modifications, swallowing maneuvers/ stimulation of oropharyngeal structures), delivery (i.e., use of technology, clinic vs. home-delivery), demographics (i.e., age, gender) and severity of one’s condition (i.e., treatment received, type/location of cancer). | dysphagia; swallowing impairment | null |
CRD42019148022 | We want to investigate whether 6-month adjuvant trastuzumab treatment is non-inferior to the standard 12-month treatment in women with HER2-positive early breast cancer. | Adjuvant trastuzumab apparently improves outcomes for women with HER2-positive early breast cancer. The standard treatment duration is 12 months, but recent studies show that shorter treatments may provide similar efficacy while reducing toxicities and cost. | null |
CRD42018088739 | What is the effect of extended anticoagulant therapy for VTE on clinically relevant outcomes including all-cause mortality, thromboembolic mortality, cardiovascular mortality and major bleeding-related mortality? | Venous thromboembolism (VTE), mortality, and anticoagulant therapy. | null |
CRD42024559904 | P: Pediatric and adults patients with osteosarcoma and acute lymphoblastic leukemia and lymphoma malignanciesI : Therapeutic and pharmacological monitoring of methorexate ( dosage analysis and adjustement ) C : NoneO : Dosage adjustment and administration of antidotes for better efficacy and avoiding toxicities | Osteosarcoma Of Bone; Non-hodgkin's Lymphoma; Acute Lymphoid Leukemia Methotrexate is used to effectively treat pediatric and adult patients with acute lymphoblastic leukemia, osteosarcoma, and lymphoma malignancies.However, it has been associated with toxic effects, including acute kidney injury,, hepatotoxicity, and myelosuppression. These toxic effects are associated with the dosing regimen and duration of exposure to above-threshold concentrations. Pediatric and adults patients with osteosarcoma and acute lymphoblastic leukemia and lymphoma malignancies Inclusion criteria :- Studies on therapeutic monitoring of methotrexate using different methods.- Studies conducted on patients suffering from osteosarcoma and acute lymphoblastic leukemia and lymphoma malignancies.- Studies involving adult and pediatric patients.- Publications in English or French- Recent publications, from the last ten years.Exclusion criteria : - Studies conducted on patients with autoimmune or inflammatory diseases.- Studies on animal models.- Grey literature and reviews. | null |
CRD42024492640 | What is the effectiveness of non medical interventions to increase empathy in adults on the Autistic Spectrum.
Population: Adults diagnosed with Autistic Spectrum Disorder.
Intervention: Non-medical interventions that aim to increase empathy.
Comparison: Control groups/active control groups.
Outcome: Post empathy scores. | Studies must have recruited participants with a diagnosis of Autistic Spectrum Disorder using recognised psychometric assessments and clinical interview as specified in the recognised classification systems of Diagnostic and Statistical Manual (DSM) 4 and 5, and International Classification of Diseases (ICD) 10 and 11.
The Empathy Quotient (EQ). Autism Spectrum Quotient (AQ). Autism Diagnostic Observation Schedule
(ADOS). Autism Diagnostic Interview (ADI). The Autism Diagnostic Interview Revised (ADI R). The Reading
the Mind in the eyes test. The Diagnostic Interview for Social and Communication Disorders (DISCO). | null |
CRD42025640905 | Disorders of consciousness present a significant challenge in clinical practice due to their complex nature and variability in outcomes. Predictive models are critical for guiding treatment decisions and setting realistic expectations for recovery, but their accuracy and applicability remain unclear. This review aims to synthesize current evidence to better understand model performance and limitations. | Disorders of consciousness (DOC) encompass a spectrum of conditions characterized by impaired awareness and responsiveness, including coma, vegetative state, and minimally conscious state. These conditions often result from severe brain injuries such as trauma, stroke, or hypoxia. The review focuses on the healthcare domain of predictive modeling for DOC, aiming to evaluate models designed to forecast outcomes, guide treatment decisions, and improve prognostication accuracy for patients with these complex conditions. | null |
CRD42023482063 | How do Umbilical cord Mesenchymal Stem Cells and Bone marrow Mesenchymal Stem Cells differ as regenerative therapeutic modalities for heart therapy ? | Heart failure, Myocardial infarction, Mesenchymal stem cells in heart therapy | null |
CRD420251018557 | To compare the differences in the effects of aerobic exercise and resistance exercise on the pulmonary function (FEV1%, FEV1/FVC), exercise tolerance (6MWT) and quality of life (SGRQ score) of elderly patients with COPD. | Patients with Chronic Obstructive Pulmonary Disease (COPD) Aerobic Exercise PICO tags selected: Resistance training | null |
CRD42023393570 | We aim to determine if embryonic stem cells transplantation therapy can significantly improve the prognosis and outcome of patients with traumatic brain injury (TBI) and traumatic spinal cord injury (TSCI), and have the potential to be a viable and sustainable treatment option for neurotrauma.
The PICO structure was used to formulate the systematic review question:
1. P (Population): Patients with traumatic brain injury and/or spinal cord injury
2. I (Intervention): Embryonic stem cells transplantation
3. C (Comparison): Placebo, alternative/ pharmacological therapy, surgical intervention
4. O (Outcome): Primary outcome – mortality; secondary outcome – Glasgow Outcome Score (GOS) for TBI, American Spinal Cord Injury Association (ASIA) impairment scale for SCI | Traumatic brain injury (TBI) and traumatic spinal cord injury (TSCI) | null |
CRD42020155575 | This review aims to evaluate the performance standards and role of imaging for whole-body MRI due to the presence of myeloma, as proposed by the Myeloma Response Assessment and Diagnosis System (MY-RADS). | Whole-body MRI in myelomva | null |
CRD42024526281 | Research Question:
"In a randomized controlled meta-analysis, how does the efficacy of coenzyme Q10 supplementation compare with that of nanocurcumin in alleviating the clinical symptoms of migraine patients within the field of non-pharmacological treatment?"
Research Objectives/Purpose:
The primary objectives of this study are:
1) To examine the clinical effectiveness of non-pharmacological treatments, in particular, the supplementation of Coenzyme Q10 and nanocurcumin, in alleviating the symptoms of migraine patients.
2) To conduct a comparative analysis of Coenzyme Q10 supplementation and nanocurcumin in symptom mitigation among migraine patients.
3) To provide an evidence-based conclusion on the preferential intervention measure for non-pharmacological migraine treatment.
In accordance with the PICOs Principle:
- Population (P): Migraine patients
- Intervention (I): Supplementation of Coenzyme Q10
- Comparison (C): Supplementation of nano-curcumin
- Outcomes (O): Reduction in clinical symptoms of migraine
- Study Design (S): A randomized controlled meta-analysis
This can be reframed into the following research purpose:
The purpose of this randomized controlled meta-analysis is to investigate the clinical effectiveness of non-pharmacological treatments, specifically comparing Coenzyme Q10 and nanocurcumin supplementation, in reducing clinical symptoms in migraine patients. The aim is to provide an evidence-based recommendation for future clinical practice and research within the scope of non-pharmacological migraine treatments. | This research focuses on the non-pharmacological treatment of migraine, specifically exploring the comparative effectiveness of supplemental turmeric (curcumin) and coenzyme Q10 in alleviating the clinical symptoms of migraine. Our study is a randomized controlled meta-analysis comparing supplemental coenzyme Q10 and nanocurcumin for migraine relief.
Migraines, characterized by recurrent, debilitating headaches, significantly impact patients' quality of life. Conventional pharmacological treatments often come with side effects and limitations, necessitating the exploration of alternative therapies. Coenzyme Q10, a naturally occurring antioxidant, and nanocurcumin, a bioavailable form of turmeric with anti-inflammatory properties, have both shown potential in migraine management. However, their comparative effectiveness remains under-explored.
This study aims to fill this gap by systematically analyzing clinical trials and meta-analyses that investigate the effects of coenzyme Q10 and nanocurcumin on migraine symptoms. By focusing on these non-pharmacological supplements, the study contributes to a broader understanding of potential migraine treatments and offers insights into more holistic, patient-centered care approaches. | null |
CRD42024589096 | The aim of this meta-analysis is to evaluate the efficacy and safety of the combination therapy of semaglutide and metformin in Chinese patients with type 2 diabetes, with a focus on glycemic control and treatment-related adverse events, in order to optimize therapeutic strategies specific to this population. | Health outcomes for type 2 diabetes typically include glycemic control, complication rates, quality of life, and long-term survival. Effective management of type 2 diabetes can reduce the risk of complications such as cardiovascular disease, nephropathy, retinopathy, and neuropathy. Key health indicators include glycated hemoglobin (HbA1c) levels, blood pressure, lipid profiles, and daily functional status. In the health sector, attention to type 2 diabetes encompasses not only treatment but also prevention, patient education, lifestyle interventions, and the formulation of health policies aimed at reducing the disease burden and improving overall patient outcomes and well-being. | null |
CRD42022340996 | • Generic question: What sort of endocrinologic follow-up is recommended to monitor the onset of endocrinologic diseases in NKX2-1-related disorders?
• Structured question: What are the best procedures for initial screening of endocrine diseases in patients with NKX2-1-related disorders? | NKX2-1-related disorders (brain-lung-thyroid syndrome) are characterized by choreoathetosis, hypothyroidism, and neonatal respiratory distress caused by variants or deletions of the NKX2-1 gene. The Systematic Review focuses on the best procedures for the early detection of endocrine diseases in patients with NKX2-1-related disorders. | null |
CRD420251029765 | The purpose of this review is to evaluate the role of colchicine | Adult patients aged 18 years and above with any cardiovascular disease (CVD) who receive colchicine. Colchicine administration as monotherapy or in combination with other standard therapies PICO tags selected: Placebo Standard treatment without colchicine or placebo. Studies including RCTs and observational studies will be included in this review. | Patients younger than 18 years old, patients not rececing colchicine and patients using colchicine for noncardiovascular reasons. Patients not receicing colchicine or any other therapy for cardiovacular conditions. Patients not receiving any therapy at all. Case report, case series,editorial and opinion articles will be excluded. |
CRD420250653697 | P：Breast Cancer
I: Mind-Body-Exercise
C: Passive control, usual care and standard therapy
O: QoL and Fatigue
S: RCT | Fatigue plays a central role in the reduced quality of life of breast cancer patients. This form of cancer-related fatigue is closely linked to the HPA axis and the immune system. Chronic stress leads to excessive activation of the hypothalamic-pituitary-adrenal (HPA) axis, increasing cortisol release. Persistent immune system activation raises energy consumption and depletes reserves, ultimately exacerbating fatigue in affected individuals. This vicious cycle of inflammation and energy loss represents a key mechanism of cancer-related fatigue.
Exercise significantly improves both physical and psychological health in cancer patients. Studies show that many experience fatigue, psychological stress, and reduced quality of life, severely impacting daily life. In this context, combining physical movement and mental focus plays a crucial role. Mind-body exercises (MBEs) are therapeutic approaches utilizing this combination. The most well-known include Tai Chi, Baduanjin, and Yoga. Studies show that MBEs enhance quality of life, fatigue, and physiological and psychological functions in cancer patients. Particularly for breast cancer patients, numerous studies confirm the positive effects of MBEs, including improved quality of life, reduced fatigue, and enhanced physical and psychological functions | null |
CRD42023447554 | Is McKenzie exercises are effective for reducing the symptoms of forward head posture | FHP is a severe condition that has risen in frequency recently. The head moves forward, shifting the Centre of gravity. The head is placed in front of the trunk as the upper body recedes and the shoulders drop forward in order to make up for the change in the Centre of gravity. A forward neck posture is one in which the head is positioned anteriorly, the normal anterior cervical convexity is elevated, and the apex of the lordotic cervical curve is at a significant distance from the LOG in compared to the ideal posture. Forward neck posture is also known as forward head posture, Scholar's neck, Reading neck, or Wearsie neck. Forward neck posture is the most prevalent postural issue, estimated to affect 66% to 90% of the population, and its impact on health is becoming more and more clear. A weakening of the deep cervical flexors, tightening of the suboccipital muscles, aberrant function of the sternocleidomastoid (SCM), and scalene muscles are all factors that contribute to this posture. | null |
CRD420250629268 | Population: The present review will include human clinical trials with a 6-month minimum follow-up.The participants included are those diagnosed with periodontitis stage III and IV, grade B or C, not medically compromised, and older than 18 years. The definition of periodontitis will be based on the latest 2017 Classification of Periodontal and Peri-Implant Diseases and Conditions consensus workshop or similar at the 1999 Classification of Periodontal and Peri-Implant Diseases and Conditions consensus workshop (Severe Generalized Chronic Periodontitis).Intervention: The test groups will include local delivery adjuncts (LDAs) with mechanical debridement (MD). The LDAs must have a main microbiological and/or clinical mechanism of action within the periodontal pocket. The sites considered will not have had any surgical intervention before the LDAs application.Comparisons: The control group will receive MD alone or MD combined with a placebo. The definition of MD in this review will include "scaling and root planing (SRP)" and “ultrasonic scaling (U/S)” as both techniques will be capable of removing calculus.Outcomes: Clinical and/or microbiological changes will be assessed. | Periodontitis The present review will include human clinical trials with a 6-month minimum follow-up.The participants included are those diagnosed with periodontitis stage III and IV, grade B or C, not medically compromised, and older than 18 years. The definition of periodontitis will be based on the latest 2017 Classification of Periodontal and Peri-Implant Diseases and Conditions consensus workshop or similar at the 1999 Classification of Periodontal and Peri-Implant Diseases and Conditions consensus workshop (Severe Generalized Chronic Periodontitis). Antimicrobials; Adjuvant Therapy PICO tags selected: Periodontal Scaling And Root Planing, Entire Mouth; Placebo | null |
CRD42024506012 | Can Retinal Vessel diameter changes predict the incidence and progression of diabetic retinopathy？
Can the retinal vessel diameter be used as an index to evaluate the therapeutic effect of diabetic retinopathy?
We included studies that explored the correlation of retinal vessel diameter with diabetic retinopathy aimed to produce a useful summary. | Diabetic retinopathy (DR) is an ocular lesion caused by retinal microvascular damage caused by diabetes. As the first blind eye disease in working age people, blindness and low vision caused by DR has become a major public health problem, and its early prevention and treatment is the focus and difficulty of clinical practice. Some biological markers based on imaging can help guide their screening, treatment decision and prognosis.Existing studies show that retinal vessel diameter has a high predictive value for the occurrence and development of diabetic retinopathy, but the level of evidence is limited and there is no meta-analysis for data merging. | null |
CRD42023423567 | I. To describe clinical characteristics, risk factors and outcomes of adult patients with hepatitis caused by Herpes simplex Virus
II: To describe laboratory characteristics and risk factors of adult patients with hepatitis caused by Herpes simplex Virus | Hepatopathy caused by herpes simplex virus types 1 or 2. | null |
CRD420251040979 | To assess the prevalence of anemia among patients with heart failure (HF). | Human adults diagnosed with heart failure (acute or chronic) and anemia, with clearly defined diagnostic criteria for both conditions, across all clinical settings Heart Failure Education; Anemia Screening; Hospital admission | null |
CRD420251005555 | null | patients with esophageal cancer confirmed by pathological diagnosis, with no exclusion based on gender, age, or clinical stage Carboplatin; Paclitaxel; Chemotherapy PICO tags selected: Cisplatin; Fluorouracil; Chemotherapy randomized controlled trial (RCT), meeting summaries, abstracts, cohort study, or case-control studies | Reviews, single case reports, expert consensuses, or editorials |
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