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of the patients was on cholesterol-lowering drugs. Patients
ischemic heart disease. An 8-year follow-up in the Copenhagen Male
hypertension and dyslipidemia: results of the AVALON trial.
[1] Reaven G, Lithell H, Landsberg L. Hypertension and associated
18(6):499–502.
[14] Lithell H. Hypertension and hyperlipidemia. A review. Am J
those patients with essential hypertension.
HDL in the amlodipine group were detected (25).
250.0
some recent studies (17–19). However, most of these
moderate hypertension, valsartan reduced TC and LDL
blocker
their combination on atherosclerosis in ApoE*3–Leiden transgenic mice. Atherosclerosis 2003; 42(1):63–70.
dihydropyridines, is a frequently prescribed antihypertensive drug as a monotherapy or usually in a combination
IL-1,
15 for Windows was used for statistical analyses.
30.5 � 4.7
Valsartan
respectively. The work was designed to study increased
50.7 � 10.7
lipoprotein was calculated by Friedewald’s formula (12).
Weight (in kg) and height (in cm) were measured, and
Urea (mg/dL)
angiotensin-converting enzyme inhibitors (16). The
mellitus and nephropathy. Int J Clin Prac 1999; 53(8):584–592.
.742
study protocol was approved by the Research and Ethics
147.1 � 39.6
studies. J Cardiovasc Risk 1996; 3(2):213–219.
In the valsartan group, no significant change was
between examined variables. To compare categorical
Med 1996; 30(101):71S–82S.
[11] Kasiske B, Ma J, Kalil R, Louis T. Effects of antihypertensive
.731
[23] Webster J, Robb O, Jeffers T, Scott A, Petrie J. Once-daily amlodipine in the treatment of mild to moderate hypertension.
lipid profile, or reduce insulin resistance according to
level and additionally decreased TC level without changing HDL levels. This may point to an immunopharmacological intervention of amlodipine on cholesterol levels.
amlodipine groups at the 12th week of antihypertensive therapy.
converting enzyme. Med Clin (Barc) 1993; 101(5):168–171.
[6] Dimmitt S, Williams P, Croft K, Beilin L. Effects of beta-blockers
U test was used as appropriate. Spearman correlation
.284
Clin Exp Hypertens Downloaded from informahealthcare.com by Nyu Medical Center on 10/16/14
serum
(TC), TG, and HDL cholesterol levels were measured
any medications were excluded. Patients were randomized to one of the following intervention protocols: (i)
studies were made on the specific groups like diabetic
blood pressure (BP), diabetes, secondary hypertension,
amlodipine in lowering serum LDL and TC is still
normotensive offspring of hypertensive parents. J Cardiovasc
At the baseline measurements, fasting plasma glucose,
92.3 � 8.8
HDL cholesterol
disorders including dyslipidemia (1). In recent studies, it
the study groups are shown in Table 1. The study was
or
previoussynergysticeffecthypothesisandmaytemporizethe
Academy, School of Medicine, Etlik-Ankara, Turkey, 3Department of Cardiology, Gulhane Medical Academy, School of
Received 12 September 2012; revised 29 September 2012; accepted 9 October 2012.
[17] Moan A, Risanger T, Eide I, Kjeldsen S. The effect of angiotensin
Copyright © Informa Healthcare USA, Inc.
our country and in the world, there are limited data in the
.284*
calcium
P
144.5 � 41.0
nervous system activity in primary hypertension. Blood Press
[13] Hanefeld M, Abletshauser C. Effect of the angiotensin II receptor
in lipid and lipoprotein values during a cross-over treatment of
P
(mg/dL)
and
.510
of the study and were not on any antihypertensive therapy.
not
cardiovascular diseases. In this study, we investigated the effects of valsartan and amlodipine on the lipid profile in
is potentially beneficial with regard to lipid metabolism in
1994; 3(3):185–188.
141.7–127.3 mg/dL; P < .05) (Figure 2) and TC levels
significant.
Dyslipidemia and the risk of incident hypertension in men.
[25] Nandeesha H, Pavithran P, Madanmohan T. Effect of antihypertensive therapy in newly diagnosed essential hypertensive men.
51.8 � 11.1
Fasting glucose (mg/dL)
lipid-lowering effects. As far as it is known, β-blockers (6)
baseline and after 12 weeks of antihypertensive therapy. The difference in total and LDL cholesterol levels were statistically
Total cholesterol (mg/dL)
200.0
13.9 � 1.3
Patients
[22] Rajagopalan S, Zannad F, Radauceanu A, et al. Effects of valsartan alone versus valsartan/simvastatin combination on ambulatory
Diagnostics (GmbH, Hamburg, Germany). Low-density
antihypertensive drugs on the lipid profile. However, in
In fact, angiotensin receptor blockers were hypothesized to
[27] Preston RA, Harvey P, Herfert O, et al. A randomized, placebocontrolled trial to evaluate the efficacy, safety, and pharmacodynamic interaction of coadministered amlodipine and atorvastatin
first member of this group, losartan, is said to have a
LDL cholesterol (mg/dL)
Social Sciences (SPSS Inc., Chicago, IL, USA) version
studies are necessary to clarify the mechanisms of these
antagonist valsartan on lipid profile and glucose metabolism in

of the patients was on cholesterol-lowering drugs. Patients

ischemic heart disease. An 8-year follow-up in the Copenhagen Male

hypertension and dyslipidemia: results of the AVALON trial.

[1] Reaven G, Lithell H, Landsberg L. Hypertension and associated

18(6):499–502.

[14] Lithell H. Hypertension and hyperlipidemia. A review. Am J

those patients with essential hypertension.

HDL in the amlodipine group were detected (25).

250.0

some recent studies (17–19). However, most of these

moderate hypertension, valsartan reduced TC and LDL

blocker

their combination on atherosclerosis in ApoE*3–Leiden transgenic mice. Atherosclerosis 2003; 42(1):63–70.

dihydropyridines, is a frequently prescribed antihypertensive drug as a monotherapy or usually in a combination

IL-1,

15 for Windows was used for statistical analyses.

30.5 � 4.7

Valsartan

respectively. The work was designed to study increased

50.7 � 10.7

lipoprotein was calculated by Friedewald’s formula (12).

Weight (in kg) and height (in cm) were measured, and

Urea (mg/dL)

angiotensin-converting enzyme inhibitors (16). The

mellitus and nephropathy. Int J Clin Prac 1999; 53(8):584–592.

.742

study protocol was approved by the Research and Ethics

147.1 � 39.6

studies. J Cardiovasc Risk 1996; 3(2):213–219.

In the valsartan group, no significant change was

between examined variables. To compare categorical

Med 1996; 30(101):71S–82S.

[11] Kasiske B, Ma J, Kalil R, Louis T. Effects of antihypertensive

.731

[23] Webster J, Robb O, Jeffers T, Scott A, Petrie J. Once-daily amlodipine in the treatment of mild to moderate hypertension.

lipid profile, or reduce insulin resistance according to

level and additionally decreased TC level without changing HDL levels. This may point to an immunopharmacological intervention of amlodipine on cholesterol levels.

amlodipine groups at the 12th week of antihypertensive therapy.

converting enzyme. Med Clin (Barc) 1993; 101(5):168–171.

[6] Dimmitt S, Williams P, Croft K, Beilin L. Effects of beta-blockers

U test was used as appropriate. Spearman correlation

.284

Clin Exp Hypertens Downloaded from informahealthcare.com by Nyu Medical Center on 10/16/14

serum

(TC), TG, and HDL cholesterol levels were measured

any medications were excluded. Patients were randomized to one of the following intervention protocols: (i)

studies were made on the specific groups like diabetic

blood pressure (BP), diabetes, secondary hypertension,

amlodipine in lowering serum LDL and TC is still

normotensive offspring of hypertensive parents. J Cardiovasc

At the baseline measurements, fasting plasma glucose,

92.3 � 8.8

HDL cholesterol

disorders including dyslipidemia (1). In recent studies, it

the study groups are shown in Table 1. The study was

or

previoussynergysticeffecthypothesisandmaytemporizethe

Academy, School of Medicine, Etlik-Ankara, Turkey, 3Department of Cardiology, Gulhane Medical Academy, School of

Received 12 September 2012; revised 29 September 2012; accepted 9 October 2012.

[17] Moan A, Risanger T, Eide I, Kjeldsen S. The effect of angiotensin

our country and in the world, there are limited data in the

.284*

calcium

P

144.5 � 41.0

nervous system activity in primary hypertension. Blood Press

[13] Hanefeld M, Abletshauser C. Effect of the angiotensin II receptor

in lipid and lipoprotein values during a cross-over treatment of

P

(mg/dL)

and

.510

of the study and were not on any antihypertensive therapy.

not

cardiovascular diseases. In this study, we investigated the effects of valsartan and amlodipine on the lipid profile in

is potentially beneficial with regard to lipid metabolism in

1994; 3(3):185–188.

141.7–127.3 mg/dL; P < .05) (Figure 2) and TC levels

significant.

Dyslipidemia and the risk of incident hypertension in men.

[25] Nandeesha H, Pavithran P, Madanmohan T. Effect of antihypertensive therapy in newly diagnosed essential hypertensive men.

51.8 � 11.1

Fasting glucose (mg/dL)

lipid-lowering effects. As far as it is known, β-blockers (6)

baseline and after 12 weeks of antihypertensive therapy. The difference in total and LDL cholesterol levels were statistically

Total cholesterol (mg/dL)

200.0

13.9 � 1.3

Patients

[22] Rajagopalan S, Zannad F, Radauceanu A, et al. Effects of valsartan alone versus valsartan/simvastatin combination on ambulatory

Diagnostics (GmbH, Hamburg, Germany). Low-density

antihypertensive drugs on the lipid profile. However, in

In fact, angiotensin receptor blockers were hypothesized to

[27] Preston RA, Harvey P, Herfert O, et al. A randomized, placebocontrolled trial to evaluate the efficacy, safety, and pharmacodynamic interaction of coadministered amlodipine and atorvastatin

first member of this group, losartan, is said to have a

LDL cholesterol (mg/dL)

Social Sciences (SPSS Inc., Chicago, IL, USA) version

studies are necessary to clarify the mechanisms of these

antagonist valsartan on lipid profile and glucose metabolism in