Ayush2609/auto_content · Datasets at Hugging Face

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218.5 � 38.6
pro-inflammatory cytokines in spontaneously hypertensive rats (29). Amlodipine decreased tumor necrosis factor
453
with increasing statin doses. Our findings are in contrast to
Committee of Gulhane Military Medical Academy.
33(5):1004–1010.
risk for cardiovascular events, usually have bad lipid profiles. Unlike the former approaches aiming only at reducing cardiovascular risks in hypertension control, now the
Kidney
side effects of antihypertensive and antihyperlipidemic
Amlodipine
220.3 � 34.8
LDL entry into cells, and thus, from the available evidence of some recent studies, decrease atherosclerosis
[9] Hernández R, Armas-Hernández M, Velasco M, Israili Z, ArmasPadilla M. Calcium antagonists and atherosclerosis protection in
They
[2] Halperin R, Sesso H, Ma J, Buring J, Stampfer M, Gaziano J.
neutral effect on metabolic parameters, ameliorate
52.8 � 11.6
Triglyceride (mg/dL)
Uric acid (mg/dL)
knowledge of the levels of plasma cholesterol could be
156.05 � 9.3
variables, chi-square test was used. Statistical significance was defined as P < .05. Statistical Package for the
cholesterol levels can be important in antihypertensive drug choice.
on
Medicine, Etlik-Ankara, Turkey
Valsartan
As a result, we observed a beneficial effect of amlodipine on lipid profile with a significant reduction of TC
0.90 � 0.12
150.0
needed (26). They said there was no significant difference
blood pressure, C-reactive protein, lipoproteins, and monocyte
For personal use only.
1Department of Cardiology, Gelibolu Hospital, Canakkale, Turkey, 2Department of Internal Medicine, Gulhane Medical
difference between the baseline and 12th week LDL,
LDL-Lowering Effect of Amlodipine
beverages in the last 30 minutes were asked to sit in a
.701
147.1 � 56.3
levels on treatment with calcium antagonists, and the
An Additional LDL-Lowering Effect of Amlodipine; Not Only
For biochemical analyses, all blood samples were drawn
MATERIAL AND METHODS
49.3 � 11.6
Blood Sample Collection and Analysis of Parameters
The difference was statistically significant (P < .05).
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the
Z. Arslan et al.
and heart failure (including decompensated heart failure).
140.7 � 32.1
newly diagnosed hypertensive patients have an altered
and apolipoprotein B levels at Week 8, compared with
improving effect ascribed to amlodipine alone apart from
The novelty of our study lies in the fact that we studied
effects on lipid metabolism. Some of them adversely
In the atorvastatin and amlodipine in patients with
effects of amlodipine on lipid profile.
Amlodipine
The effect of calcium antagonists on plasma lipid levels
volumes of the two groups were similar.
� 8.8 mm Hg in the amlodipine group and 158.45 �
50.1 � 10.8
and there was no additional lipid and C-reactive protein(CRP-) lowering effect of valsartan alone compared to its
after treatment in both groups. Mean SBP before and
duetoorapartfromagroupeffectbecauseofthedifferences
that demonstrate a decrease in TC and LDL cholesterol
measurements. Twenty-two patients were randomized
lipoprotein.
statincombination(22).TheCRP-loweringeffectincreased
Baseline
detected (13). But in our study, there was no significant
Academy. Patients presented to the internal medicine
patients with hypertension. Blood Press Suppl 1996; 2:78–81.
150.0
indicated the importance of treating dyslipidemia in
of
5.1 � 1.0
deviation, and categorical variables were defined as percentage. Data were tested for normal distribution using
10.7 and 93.8 � 8.7 mm Hg in the valsartan group,
with angiotensin converting enzyme inhibitors or angiotensin receptor antagonsists. Its main side effects are edema of
atorvastatin alone (27). There is a mentioned lipid
dyslipidemia. Higher levels of triglyceride and low-density lipoprotein (LDL) are quite strong factors for the development of
Hypertension is a modifiable risk factor for cardiovascular diseases and may be associated with several metabolic
147.3 � 58.8
increases in HDL and HDL/LDL and decrease in TC/
Continuous variables were given as mean � standard
group
Valsartan
8.2 � 0.82
National
452
metabolism according to some other studies (10,11).
(Lond) 1998; 94(6):573–578.
MPV (fL)
towards a serum cholesterol-lowering effect. In an immunopharmacological animal study, there was evidence that
Hypertension is a modifiable risk factor for cardiovascular diseases and is associated with several metabolic disorders like
8.1 � 1.3
[5] Ohta M, Tajiri Y, Yamato H, Ikeda M. Effects of exercise therapy
[10] Brook R. Mechanism of differential effects of antihypertensive
LDL cholesterol (mg/dL)
an Antihypertensive?

218.5 � 38.6

pro-inflammatory cytokines in spontaneously hypertensive rats (29). Amlodipine decreased tumor necrosis factor

453

with increasing statin doses. Our findings are in contrast to

Committee of Gulhane Military Medical Academy.

33(5):1004–1010.

risk for cardiovascular events, usually have bad lipid profiles. Unlike the former approaches aiming only at reducing cardiovascular risks in hypertension control, now the

Kidney

side effects of antihypertensive and antihyperlipidemic

Amlodipine

220.3 � 34.8

LDL entry into cells, and thus, from the available evidence of some recent studies, decrease atherosclerosis

[9] Hernández R, Armas-Hernández M, Velasco M, Israili Z, ArmasPadilla M. Calcium antagonists and atherosclerosis protection in

They

[2] Halperin R, Sesso H, Ma J, Buring J, Stampfer M, Gaziano J.

neutral effect on metabolic parameters, ameliorate

52.8 � 11.6

Triglyceride (mg/dL)

Uric acid (mg/dL)

knowledge of the levels of plasma cholesterol could be

156.05 � 9.3

variables, chi-square test was used. Statistical significance was defined as P < .05. Statistical Package for the

cholesterol levels can be important in antihypertensive drug choice.

on

Medicine, Etlik-Ankara, Turkey

Valsartan

As a result, we observed a beneficial effect of amlodipine on lipid profile with a significant reduction of TC

0.90 � 0.12

150.0

needed (26). They said there was no significant difference

blood pressure, C-reactive protein, lipoproteins, and monocyte

For personal use only.

1Department of Cardiology, Gelibolu Hospital, Canakkale, Turkey, 2Department of Internal Medicine, Gulhane Medical

difference between the baseline and 12th week LDL,

LDL-Lowering Effect of Amlodipine

beverages in the last 30 minutes were asked to sit in a

.701

147.1 � 56.3

levels on treatment with calcium antagonists, and the

An Additional LDL-Lowering Effect of Amlodipine; Not Only

For biochemical analyses, all blood samples were drawn

MATERIAL AND METHODS

49.3 � 11.6

Blood Sample Collection and Analysis of Parameters

The difference was statistically significant (P < .05).

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the

Z. Arslan et al.

and heart failure (including decompensated heart failure).

140.7 � 32.1

newly diagnosed hypertensive patients have an altered

and apolipoprotein B levels at Week 8, compared with

improving effect ascribed to amlodipine alone apart from

The novelty of our study lies in the fact that we studied

effects on lipid metabolism. Some of them adversely

In the atorvastatin and amlodipine in patients with

effects of amlodipine on lipid profile.

Amlodipine

The effect of calcium antagonists on plasma lipid levels

volumes of the two groups were similar.

� 8.8 mm Hg in the amlodipine group and 158.45 �

50.1 � 10.8

and there was no additional lipid and C-reactive protein(CRP-) lowering effect of valsartan alone compared to its

after treatment in both groups. Mean SBP before and

duetoorapartfromagroupeffectbecauseofthedifferences

that demonstrate a decrease in TC and LDL cholesterol

measurements. Twenty-two patients were randomized

lipoprotein.

statincombination(22).TheCRP-loweringeffectincreased

Baseline

detected (13). But in our study, there was no significant

Academy. Patients presented to the internal medicine

patients with hypertension. Blood Press Suppl 1996; 2:78–81.

150.0

indicated the importance of treating dyslipidemia in

of

5.1 � 1.0

deviation, and categorical variables were defined as percentage. Data were tested for normal distribution using

10.7 and 93.8 � 8.7 mm Hg in the valsartan group,

with angiotensin converting enzyme inhibitors or angiotensin receptor antagonsists. Its main side effects are edema of

atorvastatin alone (27). There is a mentioned lipid

dyslipidemia. Higher levels of triglyceride and low-density lipoprotein (LDL) are quite strong factors for the development of

Hypertension is a modifiable risk factor for cardiovascular diseases and may be associated with several metabolic

147.3 � 58.8

increases in HDL and HDL/LDL and decrease in TC/

Continuous variables were given as mean � standard

group

Valsartan

8.2 � 0.82

National

452

metabolism according to some other studies (10,11).

(Lond) 1998; 94(6):573–578.

MPV (fL)

towards a serum cholesterol-lowering effect. In an immunopharmacological animal study, there was evidence that

Hypertension is a modifiable risk factor for cardiovascular diseases and is associated with several metabolic disorders like

8.1 � 1.3

[5] Ohta M, Tajiri Y, Yamato H, Ikeda M. Effects of exercise therapy

[10] Brook R. Mechanism of differential effects of antihypertensive

LDL cholesterol (mg/dL)

an Antihypertensive?