PID
stringlengths 6
8
| Title
stringlengths 6
310
| Abstract
stringlengths 6
6.62k
| PublicationDate
stringlengths 4
27
| Journal
stringlengths 3
232
| DOI
stringclasses 1
value | Authors
listlengths 0
141
| IsRetracted
stringclasses 2
values |
|---|---|---|---|---|---|---|---|
24337903
|
Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca(2+)-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells.
|
Licochalcone A (LicA), an estrogenic flavonoid, induces apoptosis in multiple types of cancer cells. In this study, the molecular mechanisms underlying the anti-cancer effects of LicA were investigated in HepG2 human hepatocellular carcinoma cells. LicA induced apoptotic cell death, activation of caspase-4, -9, and -3, and expression of endoplasmic reticulum (ER) stress-associated proteins, including C/EBP homologous protein (CHOP). Inhibition of ER stress by CHOP knockdown or treatment with the ER stress inhibitors, salubrinal and 4-phenylbutyric acid, reduced LicA-induced cell death. LicA also induced reactive oxygen species (ROS) accumulation and the anti-oxidant N-acetylcysteine reduced LicA-induced cell death and CHOP expression. In addition, LicA increased the levels of cytosolic Ca(2+), which was blocked by 2-aminoethoxydiphenyl borate (an antagonist of inositol 1,4,5-trisphosphate receptor) and BAPTA-AM (an intracellular Ca(2+) chelator). 2-Aminoethoxydiphenyl borate and BAPTA-AM inhibited LicA-induced cell death. Interestingly, LicA induced phosphorylation of phospholipase Cγ1 (PLCγ1) and inhibition of PLCγ1 reduced cell death and ER stress. Moreover, the multi-targeted receptor tyrosine kinase inhibitors, sorafenib and sunitinib, reduced LicA-induced cell death, ER stress, and cytosolic Ca(2+) and ROS accumulation. Finally, LicA induced phosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2) and c-Met receptor and inhibition of both receptors by co-transfection with VEGFR2 and c-Met siRNAs reversed LicA-induced cell death, Ca(2+) increase, and CHOP expression. Taken together, these findings suggest that induction of ER stress via a PLCγ1-, Ca(2+)-, and ROS-dependent pathway may be an important mechanism by which LicA induces apoptosis in HepG2 hepatocellular carcinoma cells.
|
2014 Apr
|
Apoptosis : an international journal on programmed cell death
|
No DOI
|
[
{
"LastName": "Choi",
"FirstName": "A-Young",
"Affiliation": "Department of Biochemistry and Molecular Biology, School of Medicine, Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul, 130-701, Republic of Korea."
},
{
"LastName": "Choi",
"FirstName": "Ji Hyun",
"Affiliation": ""
},
{
"LastName": "Hwang",
"FirstName": "Keun-Young",
"Affiliation": ""
},
{
"LastName": "Jeong",
"FirstName": "Yeon Ju",
"Affiliation": ""
},
{
"LastName": "Choe",
"FirstName": "Wonchae",
"Affiliation": ""
},
{
"LastName": "Yoon",
"FirstName": "Kyung-Sik",
"Affiliation": ""
},
{
"LastName": "Ha",
"FirstName": "Joohun",
"Affiliation": ""
},
{
"LastName": "Kim",
"FirstName": "Sung Soo",
"Affiliation": ""
},
{
"LastName": "Youn",
"FirstName": "Jang Hyun",
"Affiliation": ""
},
{
"LastName": "Yeo",
"FirstName": "Eui-Ju",
"Affiliation": ""
},
{
"LastName": "Kang",
"FirstName": "Insug",
"Affiliation": ""
}
] |
Yes
|
33829175
|
First report of Meloidogyne naasi parasitizing turfgrass in Portugal.
|
In an exploratory sampling of a football field in Porto, Portugal, the root-knot nematode, Meloidogyne naasi, previously unreported from the Iberian Peninsula, was detected. Diagnosis was based on the analysis of perineal patterns and esterase phenotypes of females excised from grass roots, morphometrics and molecular analysis (PCR with specific primers and analysis of partial 28S sequences obtained by amplification using the primers D2A/D3B) of second-stage juveniles (J2) extracted from soil. When collected in water, J2 aggregated into a worm-star. Endospores of Pasteuria penetrans were frequently found attached to the J2. To our knowledge, this is the first report of M. naasi in Portugal and in the Iberian Peninsula, and the first report of worm-star formation in Meloidogyne.
|
2020
|
Journal of nematology
|
No DOI
|
[
{
"LastName": "Vieira Dos Santos",
"FirstName": "M Clara",
"Affiliation": "CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal."
},
{
"LastName": "Almeida",
"FirstName": "M Teresa M",
"Affiliation": "CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal."
},
{
"LastName": "Costa",
"FirstName": "Sofia R",
"Affiliation": "CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal."
}
] |
No
|
38553023
|
Syndrome of inappropriate antidiuretic hormone release secondary to central nervous system coccidioidomycosis with vasculitis.
|
A man in his 60s presented to the clinic due to night sweats and weight loss following pneumonia. He was found to have hyponatraemia due to a syndrome of inappropriate antidiuretic hormone (SIADH). CT of the thorax was concerning for pulmonary nodules. He was ultimately diagnosed with pulmonary coccidioidomycosis (CM) and started on fluconazole 400 mg daily with improvement in symptoms. Due to the report of headaches, head MRI was conducted which suggested central nervous system (CNS) involvement. Cerebrospinal fluid analysis was consistent with CNS CM and head magnetic resonance angiography confirmed the presence of CNS vasculitis. Fluconazole dose was increased to 800 mg daily which the patient continued to tolerate and showed improvement. This report depicts a case of SIADH associated with CNS CM with vasculitis and demonstrates the importance of high clinical suspicion for SIADH secondary to CNS CM in the setting of hyponatraemia and headache.
|
2024 Mar 29
|
BMJ case reports
|
No DOI
|
[
{
"LastName": "Branigan",
"FirstName": "Gregory Lawrence",
"Affiliation": "Medical Scientist Training Program, Department of Neurology, The University of Arizona College of Medicine Tucson, Tucson, Arizona, USA."
},
{
"LastName": "Ozgur",
"FirstName": "Hasan T",
"Affiliation": "Department of Medical Imaging, University of Arizona College of Medicine Tucson, Tucson, Arizona, USA."
},
{
"LastName": "Lim",
"FirstName": "James",
"Affiliation": "Department of Medicine, Divison of Infectious Disease, University of Arizona College of Medicine Tucson, Tucson, Arizona, USA."
},
{
"LastName": "Riaz",
"FirstName": "Talha",
"Affiliation": "Department of Medicine, Divison of Infectious Disease, University of Arizona College of Medicine Tucson, Tucson, Arizona, USA [email protected]."
}
] |
No
|
35772021
|
AIFM2 Is Required for High-Intensity Aerobic Exercise in Promoting Glucose Utilization.
|
Skeletal muscle is a major regulator of glycemic control at rest, and glucose utilization increases drastically during exercise. Sustaining a high glucose utilization via glycolysis requires efficient replenishment of NAD+ in the cytosol. Apoptosis-inducing mitochondrion-associated factor 2 (AIFM2) was previously shown to be a NADH oxidoreductase domain-containing flavoprotein that promotes glycolysis for diet and cold-induced thermogenesis. Here, we find that AIFM2 is selectively and highly induced in glycolytic extensor digitorum longus (EDL) muscle during exercise. Overexpression (OE) of AIFM2 in myotubes is sufficient to elevate the NAD+-to-NADH ratio, increasing the glycolytic rate. Thus, OE of AIFM2 in skeletal muscle greatly increases exercise capacity, with increased glucose utilization. Conversely, muscle-specific Aifm2 depletion via in vivo transfection of hairpins against Aifm2 or tamoxifen-inducible haploinsufficiency of Aifm2 in muscles decreases exercise capacity and glucose utilization in mice. Moreover, muscle-specific introduction of NDE1, Saccharomyces cerevisiae external NADH dehydrogenase (NDE), ameliorates impairment in glucose utilization and exercise intolerance of the muscle-specific Aifm2 haploinsufficient mice. Together, we show a novel role for AIFM2 as a critical metabolic regulator for efficient utilization of glucose in glycolytic EDL muscles.
|
2022 Oct 1
|
Diabetes
|
No DOI
|
[
{
"LastName": "Nguyen",
"FirstName": "Hai P",
"Affiliation": "Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA."
},
{
"LastName": "Villivalam",
"FirstName": "Sneha Damal",
"Affiliation": "Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, CA."
},
{
"LastName": "Jung",
"FirstName": "Byung Chul",
"Affiliation": "Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, CA."
},
{
"LastName": "You",
"FirstName": "Dongjoo",
"Affiliation": "Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, CA."
},
{
"LastName": "Lin",
"FirstName": "Frances",
"Affiliation": "Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, CA."
},
{
"LastName": "Yi",
"FirstName": "Danielle",
"Affiliation": "Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, CA."
},
{
"LastName": "Pi",
"FirstName": "Anna",
"Affiliation": "Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, CA."
},
{
"LastName": "Ma",
"FirstName": "Katherine",
"Affiliation": "Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, CA."
},
{
"LastName": "Jung",
"FirstName": "Sunhee",
"Affiliation": "Department of Biological Chemistry, University of California, Irvine, Irvine, CA."
},
{
"LastName": "Park",
"FirstName": "Sang-Hee",
"Affiliation": "Department of Biological Chemistry, University of California, Irvine, Irvine, CA."
},
{
"LastName": "Jang",
"FirstName": "Cholsoon",
"Affiliation": "Department of Biological Chemistry, University of California, Irvine, Irvine, CA."
},
{
"LastName": "Sul",
"FirstName": "Hei Sook",
"Affiliation": "Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, CA."
},
{
"LastName": "Kang",
"FirstName": "Sona",
"Affiliation": "Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, CA."
}
] |
No
|
38050079
|
Integrative multiomics enhancer activity profiling identifies therapeutic vulnerabilities in cholangiocarcinoma of different etiologies.
|
Cholangiocarcinoma (CCA) is a heterogeneous malignancy with high mortality and dismal prognosis, and an urgent clinical need for new therapies. Knowledge of the CCA epigenome is largely limited to aberrant DNA methylation. Dysregulation of enhancer activities has been identified to affect carcinogenesis and leveraged for new therapies but is uninvestigated in CCA. Our aim is to identify potential therapeutic targets in different subtypes of CCA through enhancer profiling. Integrative multiomics enhancer activity profiling of diverse CCA was performed. A panel of diverse CCA cell lines, patient-derived and cell line-derived xenografts were used to study identified enriched pathways and vulnerabilities. NanoString, multiplex immunohistochemistry staining and single-cell spatial transcriptomics were used to explore the immunogenicity of diverse CCA. We identified three distinct groups, associated with different etiologies and unique pathways. Drug inhibitors of identified pathways reduced tumour growth in in vitro and in vivo models. The first group (ESTRO), with mostly fluke-positive CCAs, displayed activation in estrogen signalling and were sensitive to MTOR inhibitors. Another group (OXPHO), with mostly BAP1 and IDH-mutant CCAs, displayed activated oxidative phosphorylation pathways, and were sensitive to oxidative phosphorylation inhibitors. Immune-related pathways were activated in the final group (IMMUN), made up of an immunogenic CCA subtype and CCA with aristolochic acid (AA) mutational signatures. Intratumour differences in AA mutation load were correlated to intratumour variation of different immune cell populations. Our study elucidates the mechanisms underlying enhancer dysregulation and deepens understanding of different tumourigenesis processes in distinct CCA subtypes, with potential significant therapeutics and clinical benefits.
|
2024 May 10
|
Gut
|
No DOI
|
[
{
"LastName": "Hong",
"FirstName": "Jing Han",
"Affiliation": "Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore."
},
{
"LastName": "Yong",
"FirstName": "Chern Han",
"Affiliation": "Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore."
},
{
"LastName": "Heng",
"FirstName": "Hong Lee",
"Affiliation": "Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore."
},
{
"LastName": "Chan",
"FirstName": "Jason Yongsheng",
"Affiliation": "Division of Medical Oncology, National Cancer Centre Singapore, Singapore."
},
{
"LastName": "Lau",
"FirstName": "Mai Chan",
"Affiliation": "Singapore Immunology Network, Agency for Science Technology and Research (A*STAR), Singapore."
},
{
"LastName": "Chen",
"FirstName": "Jianfeng",
"Affiliation": "State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China."
},
{
"LastName": "Lee",
"FirstName": "Jing Yi",
"Affiliation": "Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore."
},
{
"LastName": "Lim",
"FirstName": "Abner Herbert",
"Affiliation": "Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore."
},
{
"LastName": "Li",
"FirstName": "Zhimei",
"Affiliation": "Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore."
},
{
"LastName": "Guan",
"FirstName": "Peiyong",
"Affiliation": "Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore."
},
{
"LastName": "Chu",
"FirstName": "Pek Lim",
"Affiliation": "Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore."
},
{
"LastName": "Boot",
"FirstName": "Arnoud",
"Affiliation": "Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore."
},
{
"LastName": "Ng",
"FirstName": "Sheng Rong",
"Affiliation": "Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore."
},
{
"LastName": "Yao",
"FirstName": "Xiaosai",
"Affiliation": "Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore."
},
{
"LastName": "Wee",
"FirstName": "Felicia Yu Ting",
"Affiliation": "Institute of Molecular and Cell Biology, Integrative Biology for Theranostics Lab, Agency for Science Technology and Research (A*STAR), Singapore."
},
{
"LastName": "Lim",
"FirstName": "Jeffrey Chun Tatt",
"Affiliation": "Institute of Molecular and Cell Biology, Integrative Biology for Theranostics Lab, Agency for Science Technology and Research (A*STAR), Singapore."
},
{
"LastName": "Liu",
"FirstName": "Wei",
"Affiliation": "Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore."
},
{
"LastName": "Wang",
"FirstName": "Peili",
"Affiliation": "State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China."
},
{
"LastName": "Xiao",
"FirstName": "Rong",
"Affiliation": "State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China."
},
{
"LastName": "Zeng",
"FirstName": "Xian",
"Affiliation": "State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China."
},
{
"LastName": "Sun",
"FirstName": "Yichen",
"Affiliation": "State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China."
},
{
"LastName": "Koh",
"FirstName": "Joanna",
"Affiliation": "Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore."
},
{
"LastName": "Kwek",
"FirstName": "Xiu Yi",
"Affiliation": "Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore."
},
{
"LastName": "Ng",
"FirstName": "Cedric Chuan Young",
"Affiliation": "Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore."
},
{
"LastName": "Klanrit",
"FirstName": "Poramate",
"Affiliation": "Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand."
},
{
"LastName": "Zhang",
"FirstName": "Yaojun",
"Affiliation": "State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China."
},
{
"LastName": "Lai",
"FirstName": "Jiaming",
"Affiliation": "Department of Pancreaticobiliary Surgery, Sun Yat-sen University, Guangzhou, China."
},
{
"LastName": "Tai",
"FirstName": "David Wai Meng",
"Affiliation": "Division of Medical Oncology, National Cancer Centre Singapore, Singapore."
},
{
"LastName": "Pairojkul",
"FirstName": "Chawalit",
"Affiliation": "Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand."
},
{
"LastName": "Dima",
"FirstName": "Simona",
"Affiliation": "Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, Bucuresti, Romania."
},
{
"LastName": "Popescu",
"FirstName": "Irinel",
"Affiliation": "Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, Bucuresti, Romania."
},
{
"LastName": "Hsieh",
"FirstName": "Sen-Yung",
"Affiliation": "Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan."
},
{
"LastName": "Yu",
"FirstName": "Ming-Chin",
"Affiliation": "Department of General Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan."
},
{
"LastName": "Yeong",
"FirstName": "Joe",
"Affiliation": "Institute of Molecular and Cell Biology, Integrative Biology for Theranostics Lab, Agency for Science Technology and Research (A*STAR), Singapore."
},
{
"LastName": "Kongpetch",
"FirstName": "Sarinya",
"Affiliation": "Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand."
},
{
"LastName": "Jusakul",
"FirstName": "Apinya",
"Affiliation": "Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand."
},
{
"LastName": "Loilome",
"FirstName": "Watcharin",
"Affiliation": "Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand."
},
{
"LastName": "Tan",
"FirstName": "Patrick",
"Affiliation": "Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore."
},
{
"LastName": "Tan",
"FirstName": "Jing",
"Affiliation": "Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore."
},
{
"LastName": "Teh",
"FirstName": "Bin Tean",
"Affiliation": "Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore [email protected]."
}
] |
No
|
26781754
|
Upregulation of microRNA‑27b contributes to the migration and invasion of gastric cancer cells via the inhibition of sprouty2‑mediated ERK signaling.
|
MicroRNAs (miRs) have been demonstrated to be associated with the development, progression and prognosis of gastric cancer. However, the exact role of miR‑27b in the regulation of gastric cancer cells and the underlying mechanisms remain unclear. In the current study, it was demonstrated that miR‑27b was significantly upregulated in gastric cancer tissues and cell lines, compared with their matched normal adjacent tissues and normal gastric epithelial cells, respectively. Luciferase reporter assay data indicated that sprouty2 (SPRY2) is a direct target of miR‑27b, and miR‑27b binds to the 3'‑untranslated region of SPRY2 mRNA. Overexpression of miR‑27b led to a significant reduction in the protein expression of SPRY2, while knockdown of miR‑27b enhanced the SPRY2 protein expression in gastric cancer cells. Furthermore, knockdown of miR‑27b promoted migration and invasion in gastric cancer cells, exhibiting similar effects to those of SPRY2 overexpression on the migration and invasion of gastric cancer cells. Investigation of the molecular mechanisms identified that the activity of extracellular signal‑related kinase (ERK) signaling was mediated by miR‑27b and SPRY2 in gastric cancer cells. In addition, it was observed that SPRY2 was frequently downregulated in gastric cancer tissues compared with their matched normal adjacent tissues. In summary, it was suggested that miR‑27b promotes the migration and invasion of gastric cancer cells via inhibition of SPRY2‑mediated ERK signaling. Therefore, miR‑27b/SPRY2 may be used as a potential target for the treatment of gastric cancer.
|
2016 Mar
|
Molecular medicine reports
|
No DOI
|
[
{
"LastName": "Jiang",
"FirstName": "Juan",
"Affiliation": "School of Public Health, Central South University, Changsha, Hunan 410008, P.R. China."
},
{
"LastName": "Yi",
"FirstName": "Bo",
"Affiliation": "Department of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China."
},
{
"LastName": "Qin",
"FirstName": "Chunxiang",
"Affiliation": "Department of Obstetrics, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China."
},
{
"LastName": "Ding",
"FirstName": "Siqing",
"Affiliation": "Department of Nursing, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China."
},
{
"LastName": "Cao",
"FirstName": "Wei",
"Affiliation": "Department of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China."
}
] |
Yes
|
38410190
|
NAMPT‑NAD(+) is involved in the senescence‑delaying effects of saffron in aging mice.
|
As the proportion of the elderly population grows rapidly, the senescence-delaying effects of Traditional Chinese Medicine is being investigated. The aim of the present study was to investigate the senescence-delaying effects of saffron in naturally aging mice. The active ingredients in an aqueous saffron extract were determined using high-performance liquid chromatography (HPLC). Mice were divided into saffron (8- and 16-months-old) and control groups (3-, 8-, and 16-months-old), and saffron extract was administered to the former groups for 8 weeks. The open field test and Barnes maze test were used to evaluate the locomotor activity, learning and memory function of the mice. The levels of inflammatory factors in the brain were determined by ELISA. In addition, the activities of acetylcholinesterase (AChE) and superoxide dismutase, and the contents of malondialdehyde and nicotinamide adenine dinucleotide (NAD[+]) were detected by enzyme immunoassay, and the content of NAMPT was detected by ELISA, western blotting and reverse transcription-quantitative PCR. The cellular distribution of NAMPT and synaptic density were evaluated by immunofluorescence, and the pathological morphologies of the liver, skin, kidneys were observed by hematoxylin and eosin staining. HPLC revealed that the crocin and picrocrocin contents of the saffron extract were 19.56±0.14 and 12.00±0.13%, respectively. Saffron exhibited the potential to improve the learning and memory function in aging mice as it increased synaptic density and decreased AChE activity. Also, saffron ameliorated the pathological changes associated with organ aging, manifested by increasing the number of hepatocytes and the thickness of the skin, and preventing the aging-induced ballooning and bleeding in the kidneys. Furthermore, saffron increased the contents of NAMPT and NAD[+] in the brain and decreased the content of NAMPT in the serum. In addition, it changed the cellular distribution of NAMPT in aging mice, manifested as reduced NAMPT expression in microglia and astrocytes, and increased NAMPT expression in neurons. Saffron also decreased the contents of proinflammatory cytokines and oxidative stress factors in aging mice. Altogether, these findings indicate that saffron exerts senescence-delaying effects in naturally aging mice, which may be associated with the NAMPT-NAD[+] pathway.
|
2024 Mar
|
Experimental and therapeutic medicine
|
No DOI
|
[
{
"LastName": "Xiao",
"FirstName": "Ling",
"Affiliation": "Department of Pharmacology, School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 311300, P.R. China."
},
{
"LastName": "Sun",
"FirstName": "Runxuan",
"Affiliation": "Department of Pharmacology, School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 311300, P.R. China."
},
{
"LastName": "Han",
"FirstName": "Yubin",
"Affiliation": "Department of Pharmacology, School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 311300, P.R. China."
},
{
"LastName": "Xia",
"FirstName": "Linhan",
"Affiliation": "Department of Pharmacology, School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 311300, P.R. China."
},
{
"LastName": "Lin",
"FirstName": "Kexin",
"Affiliation": "Department of Pharmacology, School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 311300, P.R. China."
},
{
"LastName": "Fu",
"FirstName": "Wanyan",
"Affiliation": "Department of Pharmacology, School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 311300, P.R. China."
},
{
"LastName": "Zhong",
"FirstName": "Kai",
"Affiliation": "Department of Pharmacology, School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 311300, P.R. China."
},
{
"LastName": "Ye",
"FirstName": "Yilu",
"Affiliation": "Department of Pharmacology, School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 311300, P.R. China."
}
] |
No
|
36105439
|
Clinical Characteristics and Gene Mutation Analysis of Poststroke Epilepsy.
|
Epilepsy is one of the most common brain disorders worldwide. Poststroke epilepsy (PSE) affects functional retrieval after stroke and brings considerable social values. A stroke occurs when the blood circulation to the brain fails, causing speech difficulties, memory loss, and paralysis. An electroencephalogram (EEG) is a tool that may detect anomalies in brain electrical activity, including those induced by a stroke. Using EEG data to determine the electrical action in the brains of stroke patients is an effort to measure therapy. Hence in this paper, deep learning assisted gene mutation analysis (DL-GMA) was utilized for classifying poststroke epilepsy in patients. This study suggested a model categorizing poststroke patients based on EEG signals that utilized wavelet, long short-term memory (LSTM), and convolutional neural networks (CNN). Gene mutation analysis can help determine the cause of an individual's epilepsy, leading to an accurate diagnosis and the best probable medical management. The test outcomes show the viability of noninvasive approaches that quickly evaluate brain waves to monitor and detect daily stroke diseases. The simulation outcomes demonstrate that the proposed GL-GMA achieves a high accuracy ratio of 98.3%, a prediction ratio of 97.8%, a precision ratio of 96.5%, and a recall ratio of 95.6% and decreases the error rate 10.3% compared to other existing methods.
|
2022
|
Contrast media & molecular imaging
|
No DOI
|
[
{
"LastName": "Shen",
"FirstName": "Deju",
"Affiliation": "Department of Neurology, Longyan People Hospital, Longyan 364000, Fujian, China."
},
{
"LastName": "Deng",
"FirstName": "Yuqin",
"Affiliation": "Department of Neurology, Longyan People Hospital, Longyan 364000, Fujian, China."
},
{
"LastName": "Lin",
"FirstName": "Chunyan",
"Affiliation": "Department of Neurology, Longyan People Hospital, Longyan 364000, Fujian, China."
},
{
"LastName": "Li",
"FirstName": "Jianshu",
"Affiliation": "Department of Neurology, Longyan People Hospital, Longyan 364000, Fujian, China."
},
{
"LastName": "Lin",
"FirstName": "Xuehua",
"Affiliation": "Department of Neurology, Longyan People Hospital, Longyan 364000, Fujian, China."
},
{
"LastName": "Zou",
"FirstName": "Chaoning",
"Affiliation": "Department of Neurology, Longyan People Hospital, Longyan 364000, Fujian, China."
}
] |
Yes
|
24116969
|
Association between childhood obesity, cognitive development, physical fitness and social-emotional wellbeing in a transitional economy.
|
It has been suggested that obese children have lower cognitive function, demonstrate poorer physical performance and are more susceptible to social-emotional problems. To describe associations between human physical growth, cognitive development, physical fitness and social-emotional characteristics of obese and non-obese children and to verify the predictors of intellectual coefficient by socioeconomic status (SES). A sample of 107 non-obese (N-Ob) children [-1 z-score body mass index (BMI) ≤1 z-score] and 108 obese (Ob) children [2 z-score ≤BMI ≤5 z-score] from a larger cohort was evaluated. Intellectual coefficient (IQ), social-emotional wellbeing (SEW), 6-minute walk test (6MWT) and SES (mid-low, low and very low) were assessed. Ob children were taller, heavier and present more height for age and BMI than N-Ob children (p < 0.001). A significant correlation between IQ and SEW (r = 0.14), 6MWT and BMI z-score (r = -0.18) and 6MWT and SEW (r = 0.15) was found. Multiple regression analysis revealed that BMI z-score had a negative impact on IQ in the mid-low SES sub-group and that SEW had a positive effect on IQ in the very-low SES sub-group. In Chilean pre-school children from low-income families cognitive ability varied according to SES.
|
2014 Mar-Apr
|
Annals of human biology
|
No DOI
|
[
{
"LastName": "Galván",
"FirstName": "Marcos",
"Affiliation": "Institute of Health Sciences (ICSA), U. Autónoma de Hidalgo , Pachuca , México ."
},
{
"LastName": "Uauy",
"FirstName": "Ricardo",
"Affiliation": ""
},
{
"LastName": "López-Rodríguez",
"FirstName": "Guadalupe",
"Affiliation": ""
},
{
"LastName": "Kain",
"FirstName": "Juliana",
"Affiliation": ""
}
] |
No
|
36247861
|
Nursing Teaching Curriculum Setting by Introducing Postcompetency Model under the Vision of Internet Informatization.
|
The nursing curriculum is to be modernized to improve the student's skills in meeting the recent trends in medical and healthcare fields. The curriculum improvements are based on expert recommendations, authors, and informative data from different web sources. The challenging task is to improve the readability and understandability of the curriculum to real-time standards. Considering the above facts, this article introduces a refined curriculum with Internet information analysis (RC-IIA) method. The proposed method incorporates the distributed Internet, journal, and previous curriculum information within the active nursing syllabus. This prevents repetitions and less-informative content within the active curriculum. Besides, classification learning for knowledge-based representations is used within the curriculum to improve competency. Based on the refined information, a recommendation-based curriculum is preferred for varying information across different standards. The proposed analysis method relies on existing and distributed information across multiple curriculum providers for leveraging the visibility and prolonging the stealth of the nursing curriculum.
|
2022
|
Contrast media & molecular imaging
|
No DOI
|
[
{
"LastName": "Xiao",
"FirstName": "Lan",
"Affiliation": "Department of Head and Neck Oncology, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China."
},
{
"LastName": "Men",
"FirstName": "Yi",
"Affiliation": "Department of Head and Neck Oncology, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China."
}
] |
Yes
|
38742176
|
Old woman with Sheehan's syndrome suffered severe hyponatremia following percutaneous coronary intervention: a case report and review of literature.
|
Glucocorticoid deficiency can lead to hypoglycemia, hypotension, and electrolyte disorders. Acute glucocorticoid deficiency under stress is very dangerous. Here, we present a case study of an elderly patient diagnosed with Sheehan's syndrome, manifesting secondary adrenal insufficiency and secondary hypothyroidism, managed with daily prednisone and levothyroxine therapy. She was admitted to our hospital due to acute non-ST segment elevation myocardial infarction. The patient developed nausea and limb twitching post-percutaneous coronary intervention, with subsequent diagnosis of hyponatremia. Despite initial intravenous sodium supplementation failed to rectify the condition, and consciousness disturbances ensued. However, administration of 50 mg hydrocortisone alongside 6.25 mg sodium chloride rapidly ameliorated symptoms and elevated blood sodium levels. Glucocorticoid deficiency emerged as the primary etiology of hyponatremia in this context, exacerbated by procedural stress during percutaneous coronary intervention. Contrast agent contributed to blood sodium dilution. Consequently, glucocorticoid supplementation emerges as imperative, emphasizing the necessity of stress-dose administration of glucocorticoid before the procedure. Consideration of shorter intervention durations and reduced contrast agent dosages may mitigate severe hyponatremia risks. Moreover, it is crucial for this patient to receive interdisciplinary endocrinologist management. In addition, Sheehan's syndrome may pose a risk for coronary atherosclerotic disease.
|
2024
|
Frontiers in cardiovascular medicine
|
No DOI
|
[
{
"LastName": "Gao",
"FirstName": "Jie",
"Affiliation": "School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China."
},
{
"LastName": "Wang",
"FirstName": "Yuehai",
"Affiliation": "Cardiology Department and Experimental Animal Center, Liaocheng People's Hospital of Shandong University and Liaocheng Hospital Affiliated to Shandong First Medical University, Liaocheng, Shandong, China."
},
{
"LastName": "Zhang",
"FirstName": "Anqi",
"Affiliation": "Department of Central Laboratory, Liaocheng People's Hospital, Liaocheng, Shandong, China."
},
{
"LastName": "Pang",
"FirstName": "Huihui",
"Affiliation": "School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China."
},
{
"LastName": "Wang",
"FirstName": "Fei",
"Affiliation": "Department of Cardiology, Shandong Corps Hospital of Chinese People's Armed Police Forces, Jinan, China."
}
] |
No
|
35141188
|
Utilization of a Mobile Multifunctional Workstation for Coronavirus Nasopharyngeal/Oropharyngeal Specimen Collection.
|
This study aimed to explore the utilization of a mobile multifunctional workstation for COVID-19 sample collection. Twenty-four nurses and 150 individuals who took nucleic acid tests using mobile multifunctional workstations in Beijing Youan Hospital, Capital Medical University, from September to November 2020, were enrolled in the study as the observation group. As the control group, we included 36 nurses and 150 individuals who did not use the workstations from June to September 2020. We compared the two groups on (1) comfort of working environment, self-perceived security, the convenience of information system, operational process flexibility, pharyngeal acquisition visibility, and effectiveness of communication among nurses; and (2) self-perceived safety, waiting time, and overall satisfaction among individuals who took nucleic acid tests. The satisfaction score of nurses in the observation group of nurses were significantly higher than those of the control group (OR = 17.297 95% CI:4.294, 69.673), as well as the convenience of the information system (OR = 6.250 95% CI: 1.775, 22.008), and communication effectiveness (OR = 5.588 95% CI: 1.590, 19.646). Among individuals who took nucleic acid tests, the overall satisfaction (P < 0.05) and self-perceived security (P < 0.05) had statistical differences between the observation group and the control group. The mobile multifunctional workstation for specimen collection could improve the comfort of the working environment, the convenience of information systems, and the effectiveness of communication among nurses.It can improve satisfaction and self-perceived security among people who took nucleic acid tests.
|
2021
|
Frontiers in public health
|
No DOI
|
[
{
"LastName": "Lian",
"FirstName": "Xiaojing",
"Affiliation": "Integrated Traditional Chinese and Western Medicine Center, Beijing Youan Hospital, Capital Medical University, Beijing, China."
},
{
"LastName": "Zhang",
"FirstName": "Lili",
"Affiliation": "Nursing Department of Beijing Youan Hospital, Capital Medical University, Beijing, China."
},
{
"LastName": "Zhao",
"FirstName": "Yang",
"Affiliation": "Department of Dermatology, Shunyi Maternal and Children's Hospital of Beijing Children's Hospital, Beijing, China."
},
{
"LastName": "Li",
"FirstName": "Yuhua",
"Affiliation": "Second Department of Infection, Beijing Youan Hospital, Capital Medical University, Beijing, China."
},
{
"LastName": "Jing",
"FirstName": "Xuemin",
"Affiliation": "Intervention Department, Beijing Youan Hospital, Capital Medical University, Beijing, China."
},
{
"LastName": "Liu",
"FirstName": "Xin",
"Affiliation": "Department of Critical Care Medicine, Beijing Youan Hospital, Capital Medical University, Beijing, China."
},
{
"LastName": "Han",
"FirstName": "Jianing",
"Affiliation": "Department of Infection, Beijing Youan Hospital, Capital Medical University, Beijing, China."
},
{
"LastName": "Ma",
"FirstName": "Jianhong",
"Affiliation": "Department of Infection, Beijing Youan Hospital, Capital Medical University, Beijing, China."
},
{
"LastName": "Zhang",
"FirstName": "Yongyong",
"Affiliation": "Outpatient Department, Beijing Youan Hospital, Capital Medical University, Beijing, China."
},
{
"LastName": "Guo",
"FirstName": "Huimin",
"Affiliation": "Nursing Department of Beijing Youan Hospital, Capital Medical University, Beijing, China."
},
{
"LastName": "Huang",
"FirstName": "Xiaojie",
"Affiliation": "Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing, China."
}
] |
No
|
24532928
|
Initial experience with lingual mucosal graft urethroplasty for anterior urethral strictures.
|
To present the feasibility of lingual mucosal graft urethroplasty in anterior urethral strictures and appraisal of donor site morbidity. From November 2007 to December 2010, 14 patients underwent dorsal onlay lingual mucosal graft urethroplasty for anterior urethral strictures. Lingual mucosal graft was harvested from the lateral and undersurface of the tongue. Check micturating cystourethrograms were done 2 weeks after catheter removal and uroflowmetry after 3 months. Success was defined as normal uroflowmetry rates at 3 months in the absence of any postoperative instrumentation. Tongue was assessed for any residual pain, taste disturbances or restricted movement at 3 months. Four patients had submucosal fibrosis of the oral cavity and their buccal mucosa was unfit for grafting. Mean (range) stricture length was 5 (3-16) cm and the operation time 170 (140-210) min. Graft width averaged 1.6 cm. Average length of harvested graft was 6.5 cm. Mean duration of follow-up was 12.8 months. Two patients developed stricture at the proximal anastomotic site. There were no donor site complications. Lingual mucosal graft harvesting is simple, gives graft lengths comparable to buccal mucosa and is associated with negligible donor site morbidity.
|
2013 Jan
|
Medical journal, Armed Forces India
|
No DOI
|
[
{
"LastName": "Srivastava",
"FirstName": "Anand",
"Affiliation": "Senior Advisor (Surgery & Urology), Army Hospital (R&R), Delhi Cantt, India."
},
{
"LastName": "Dutta",
"FirstName": "A",
"Affiliation": "Classified Specialist (Surgery and Urology), Military Hospital, Jallandhar Cantt, India."
},
{
"LastName": "Jain",
"FirstName": "D K",
"Affiliation": "Consultant (Surgery and Urology), Command Hospital (SC), Pune, India."
}
] |
No
|
22295274
|
A case of psychosis after use of a detoxification kit and a review of techniques, risks, and regulations associated with the subversion of urine drug tests.
|
The practice of drug testing in the workplace has been adopted for US federal government employees, and many state and local governments as well as private businesses have followed suit. However, a parallel industry dedicated to subverting the results of urine drug testing has emerged with little or no regulation. First, the case of a 19-year-old man who developed psychosis after the use of a detoxification kit is presented. Second, a review of the existing literature on the techniques, risks, and regulations associated with the use of drug tampering kits is provided. PubMed, Cochrane Database, and Google Scholar were searched using the keywords UDS, urine toxicology, pass the drug test, and clean UA, with no restrictions on publication date. Case reports, letters to the editor, and original research and review articles in multiple languages were reviewed, as were federal regulations and acts on the topic. The search yielded 4,082 results, of which 49 articles were selected for relevance. Some articles were later omitted as they had cited the original article and had nothing new to offer. Three commonly used tampering techniques are in vivo adulteration, urine substitution, and in vitro adulteration. Review of the literature regarding the risks involved with use of tampering kits yielded no results. In 1986, an executive order was issued requiring all federal employees to refrain from illicit drug use, and the 1988 Drug-Free Workplace Act precipitated the Substance Abuse and Mental Health Services Administration guidelines and their subsequent revisions. Recently, many states have made regulatory efforts to bring drug test defrauding under the ambit of law. Clinicians need to be aware of the tampering techniques and the possibility of false-negative urine drug tests. Cognizance of inherent risks involved with using these techniques including psychiatric and/or medical complications is also warranted. The manufacture, sale, and use of these products have little or no regulation by state or federal authorities, making them potentially dangerous and imposing new challenges in testing for abused drugs. The extent of use of these products and techniques is not known at this time and is an area that warrants further research.
|
2011
|
The primary care companion for CNS disorders
|
No DOI
|
[
{
"LastName": "Mittal",
"FirstName": "Moneeshindra Singh",
"Affiliation": "Department of Psychiatry and Behavioral Sciences, University of Kansas School of Medicine, Wichita, Kansas, USA."
},
{
"LastName": "Kalia",
"FirstName": "Rachna",
"Affiliation": ""
},
{
"LastName": "Khan",
"FirstName": "Ahsan Y",
"Affiliation": ""
}
] |
No
|
38592027
|
Recent advances in the approaches for improving the photovoltaic performance of porphyrin-based DSSCs.
|
Among other photovoltaic techniques including perovskite solar cells and organic solar cells, dye-sensitized solar cells (DSSCs) are considered to be a potential alternative to conventional silicon solar cells. Porphyrins are promising dyes with the properties of easy modification and superior light-harvesting capability. However, porphyrin dyes still suffer from a number of unfavorable aspects, which need to be addressed in order to improve the photovoltaic performance. This feature article briefly summarizes the recent progress in improving the Voc and Jsc of porphyrin-based DSSCs in terms of molecular engineering by modifying the porphyrin macrocycle, donor and acceptor moieties of the porphyrin dyes, coadsorption of the porphrin dyes with bulky coadsorbents like chenodeoxycholic acid (CDCA), and cosensitization of the porphyrin dyes with metal-free organic dyes. Notably, concerted companion (CC) dyes are described in detail, which have been constructed by linking a porphyrin dye subunit and a metal-free organic dye subunit with flexible alkoxy chains to achieve panchromatic absorption and concerted enhancement of Voc and Jsc. In one sentence, this article is expected to provide further insights into the development of high performance DSSCs through the design and syntheses of efficient porphyrin dyes and CC dyes in combination with device optimization to achieve simultaneously elevated Voc and Jsc, which may inspire and promote further progress in the commercialization of the DSSCs.
|
2024 Apr 23
|
Chemical communications (Cambridge, England)
|
No DOI
|
[
{
"LastName": "Huang",
"FirstName": "Shucheng",
"Affiliation": "Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China. [email protected]."
},
{
"LastName": "Li",
"FirstName": "Qizhao",
"Affiliation": "Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China. [email protected]."
},
{
"LastName": "Li",
"FirstName": "Shijun",
"Affiliation": "College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, China."
},
{
"LastName": "Li",
"FirstName": "Chengjie",
"Affiliation": "Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China. [email protected]."
},
{
"LastName": "Tan",
"FirstName": "Haijun",
"Affiliation": "Guangxi Key Laboratory of Electrochemical and Magneto-chemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China. [email protected]."
},
{
"LastName": "Xie",
"FirstName": "Yongshu",
"Affiliation": "Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China. [email protected]."
}
] |
No
|
30486759
|
VDR gene FokI polymorphism as a poor prognostic factor for papillary thyroid cancer.
|
This is the first study to investigate the effect of vitamin D receptor (VDR) gene single-nucleotide polymorphisms on the clinicopathologic features of papillary thyroid cancer in Turkey. A total of 165 patients with papillary thyroid cancer and 172 controls were included in this case-control study. VDR gene single-nucleotide polymorphisms FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) were evaluated using reverse-transcription polymerase chain reaction. VDR gene polymorphisms BsmI, ApaI, and TaqI did not differ between the papillary thyroid cancer group and control group (p > 0.05, each). BsmI, ApaI, and TaqI were not associated with papillary thyroid cancer risk. The VDR gene FokI CT/TT genotype was associated with an increased papillary thyroid cancer risk (CT vs CC: odds ratio = 1.71, 95% confidence interval = 1.15-2.76, p = 0.028; TT vs CC: odds ratio = 2.44, 95% confidence interval = 1.29-4.62, p = 0.005; CT/TT vs CC: odds ratio = 1.88, 95% confidence interval = 1.20-2.96, p = 0.006; CT/CC vs TT: odds ratio = 1.80, 95% confidence interval = 1.05-3.20, p = 0.041). VDR gene polymorphisms were not in linkage disequilibrium. The FokI TT genotype was associated with having T3 and T4, stage III/IV, extra-thyroidal invasion. The FokI CT/TT or TT genotype was associated with developing N1 status, multifocality, tumor size ≥10 mm, and treatment with radioiodine therapy. Persistence/recurrence did not differ between the FokI genotypes. Carriers of the FokI T allele were at an increased risk of more advanced tumor-node-metastasis stage, greater tumor size, multifocality, and extra-thyroidal invasion of papillary thyroid cancer compared with the CC genotype. VDR gene FokI T allele and TT genotype correlated with aggressiveness of papillary thyroid cancer; thus, FokI could be useful as a poor prognostic factor to assess the high risk of papillary thyroid cancer.
|
2018 Nov
|
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
|
No DOI
|
[
{
"LastName": "Beysel",
"FirstName": "Selvihan",
"Affiliation": "1 Department of Endocrinology and Metabolism, Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey."
},
{
"LastName": "Eyerci",
"FirstName": "Nilnur",
"Affiliation": "4 Department of Genetic Research, Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey."
},
{
"LastName": "Pinarli",
"FirstName": "Ferda Alparslan",
"Affiliation": "4 Department of Genetic Research, Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey."
},
{
"LastName": "Apaydin",
"FirstName": "Mahmut",
"Affiliation": "1 Department of Endocrinology and Metabolism, Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey."
},
{
"LastName": "Kizilgul",
"FirstName": "Muhammed",
"Affiliation": "1 Department of Endocrinology and Metabolism, Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey."
},
{
"LastName": "Caliskan",
"FirstName": "Mustafa",
"Affiliation": "1 Department of Endocrinology and Metabolism, Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey."
},
{
"LastName": "Ozcelik",
"FirstName": "Ozgur",
"Affiliation": "1 Department of Endocrinology and Metabolism, Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey."
},
{
"LastName": "Kan",
"FirstName": "Seyfullah",
"Affiliation": "1 Department of Endocrinology and Metabolism, Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey."
},
{
"LastName": "Cakal",
"FirstName": "Erman",
"Affiliation": "1 Department of Endocrinology and Metabolism, Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey."
}
] |
No
|
28848300
|
Molecular characterization of Hepatozoon felis in Rhipicephalus sanguineus ticks infested on captive lions (Panthera leo).
|
Hepatozoon spp. are protozoan parasites that infect a wide range of domestic and wild animals. The infection occurs by ingestion of an infected tick. This study was carried out to detect and characterize Hepatozoon spp. in ticks collected from captive lions (Panthera leo) in Thailand based on the partial 18S rRNA gene sequence. A total of 30 ticks were collected and identified as Rhipicephalus sanguineus. The collected ticks were separated into 10 tick pools by sex and life stages. Of the 10 tick pools examined, only one (10%) was found to be infected with the Hepatozoon species. Sequencing and phylogenetic analysis showed a clustering of the partial 18S rRNA gene sequence like that of H. felis from the GenBank database. This is the first report of H. felis in R. sanguineus ticks collected from captive lions in Thailand. Our results indicated that R. sanguineus may be a possible vector of feline Hepatozoon in Thailand.
|
2017 Sep
|
Journal of parasitic diseases : official organ of the Indian Society for Parasitology
|
No DOI
|
[
{
"LastName": "Bhusri",
"FirstName": "Benjaporn",
"Affiliation": "The Monitoring and Surveillance Center for Zoonotic Diseases in Wildlife and Exotic Animals, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, 73170 Thailand."
},
{
"LastName": "Sariya",
"FirstName": "Ladawan",
"Affiliation": "The Monitoring and Surveillance Center for Zoonotic Diseases in Wildlife and Exotic Animals, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, 73170 Thailand."
},
{
"LastName": "Mongkolphan",
"FirstName": "Chalisa",
"Affiliation": "The Monitoring and Surveillance Center for Zoonotic Diseases in Wildlife and Exotic Animals, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, 73170 Thailand."
},
{
"LastName": "Suksai",
"FirstName": "Parut",
"Affiliation": "The Monitoring and Surveillance Center for Zoonotic Diseases in Wildlife and Exotic Animals, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, 73170 Thailand."
},
{
"LastName": "Kaewchot",
"FirstName": "Supakarn",
"Affiliation": "Department of Natural Parks, Wildlife and Plant Conservation, Bangkok, 10900 Thailand."
},
{
"LastName": "Changbunjong",
"FirstName": "Tanasak",
"Affiliation": "The Monitoring and Surveillance Center for Zoonotic Diseases in Wildlife and Exotic Animals, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, 73170 Thailand."
}
] |
No
|
31775008
|
Opioid-Related Hospitalization and Its Association With Chronic Diseases: Findings From the National Inpatient Sample, 2011-2015.
|
Chronic disease and opioid-related hospitalizations in the United States are increasing. We analyzed nationally representative data on patients aged 18 years or older from the 2011-2015 National Inpatient Sample to assess the association between opioid-related hospitalization and chronic diseases. We found that most patients with opioid-related hospitalization were white, aged 35-54 years, in urban hospitals, and had 2 or more comorbid conditions. Patients with 2 or more chronic conditions accounted for more than 90% of opioid-related hospitalizations in all years. The results suggest a need for targeted interventions to prevent opioid misuse in patients with multiple chronic conditions.
|
2019 Nov 27
|
Preventing chronic disease
|
No DOI
|
[
{
"LastName": "Rajbhandari-Thapa",
"FirstName": "Janani",
"Affiliation": "Department of Health Policy and Management, College of Public Health, University of Georgia, Athens, GA 30602. Email: [email protected]."
},
{
"LastName": "Zhang",
"FirstName": "Donglan",
"Affiliation": "Department of Health Policy and Management, College of Public Health, University of Georgia, Athens, Georgia."
},
{
"LastName": "Padilla",
"FirstName": "Heather M",
"Affiliation": "Department of Health Promotion and Behavior, College of Public Health, University of Georgia, Athens, Georgia."
},
{
"LastName": "Chung",
"FirstName": "Sae Rom",
"Affiliation": "Department of Financial Planning, Housing, and Consumer Economics, College of Family and Consumer Sciences, University of Georgia, Athens, Georgia."
}
] |
No
|
35971403
|
Application of Image Processing Technology in Aerobics Injury Diagnosis.
|
Aerobics sports injury diagnosis is a rapid diagnosis of sports injuries caused by athletes in the process of aerobics training or competition. The purpose of this paper is to use image processing technology to study and analyze the diagnosis of aerobics sports injury, so that the diagnosis results can be obtained more quickly and effectively. This paper first introduces the image processing technology and then analyzes the sports injury in colleges and universities. Firstly, the algorithm formula of image processing technology is given, and then the algorithm is introduced into the dynamic analysis of aerobics injury diagnosis. The two are compared through example analysis. The experimental results show that joint strain, sprains, and muscle strain are the main types of sports injury of College Aerobics students, reaching 59, 50, and 31 times, respectively. When using image processing technology in the diagnosis of sports injury, the diagnosis results can be obtained quickly and effectively.
|
2022
|
Emergency medicine international
|
No DOI
|
[
{
"LastName": "Zhang",
"FirstName": "Duo",
"Affiliation": "Physical Education Department, Civil Aviation Flight University of China, Guanghan 618307, Sichuan, China."
},
{
"LastName": "Tian",
"FirstName": "Yan",
"Affiliation": "College of Physical Education, Chengdu University of TCM, Chengdu 611137, Sichuan, China."
}
] |
Yes
|
29280385
|
Formulation and statistical optimization of intravenous temozolomide-loaded PEGylated liposomes to treat glioblastoma multiforme by three-level factorial design.
|
The aim of the presented study was to develop PEGylated liposomes of Temozolomide (TMZ) that provide optimum drug concentration at tumor site. Reverse phase evaporation (REV) method was used to prepare TMZ-loaded PEGylated liposomes. Formulation was optimized by using design expert software by 3[2] factorial design. The physicochemical properties including size, morphology, entrapment efficiency, drug loading, etc. of formulated liposomes were evaluated. Finally, the optimized formulation was selected for in vitro drug release and stability study. In vivo pharmacokinetic study in rats showed that TMZ-loaded PEGylated liposomes leads to 1.6-fold increase in AUCTotal in blood and 4.2-fold increase in brain as compared to free drug solution. This formulated PEGylated liposomes offers a promising approach for treatment of Glioblastoma Multiforme.
|
2018 Jun
|
Drug development and industrial pharmacy
|
No DOI
|
[
{
"LastName": "Vanza",
"FirstName": "Jigar",
"Affiliation": "a Faculty of Pharmacy , The Maharaja Sayajirao University of Baroda , Vadodara , India."
},
{
"LastName": "Jani",
"FirstName": "Parva",
"Affiliation": "a Faculty of Pharmacy , The Maharaja Sayajirao University of Baroda , Vadodara , India."
},
{
"LastName": "Pandya",
"FirstName": "Nilima",
"Affiliation": "a Faculty of Pharmacy , The Maharaja Sayajirao University of Baroda , Vadodara , India."
},
{
"LastName": "Tandel",
"FirstName": "Hemal",
"Affiliation": "a Faculty of Pharmacy , The Maharaja Sayajirao University of Baroda , Vadodara , India."
}
] |
No
|
26807178
|
Erythropoietin regulates Treg cells in asthma through TGFβ receptor signaling.
|
Asthma is a chronic inflammatory disorder of the airways, the development of which is suppressed by regulatory T cells (Treg). Erythropoietin (EPO) is originally defined as a hematopoietic growth factor. Recently, the anti-inflammatory effects of EPO in asthma have been acknowledged. However, the underlying mechanisms remain ill-defined. Here, we showed that EPO treatment significantly reduced the severity of an ovalbumin (OVA)-induced asthma in mice, seemingly through promoting Foxp3-mediated activation of Treg cells in OVA-treated mouse lung. The activation of Treg cells resulted from increases in transforming growth factor β1 (TGFβ1), which were mainly produced by M2 macrophages (M2M). In vitro, Co-culture with M2M increased Foxp3 levels in Treg cells and the Treg cell number, in a TGFβ receptor signaling dependent manner. Moreover, elimination of macrophages abolished the therapeutic effects of EPO in vivo. Together, our data suggest that EPO may increase M2M, which activate Treg cells through TGFβ receptor signaling to mitigate the severity of asthma.
|
2015
|
American journal of translational research
|
No DOI
|
[
{
"LastName": "Wan",
"FirstName": "Guoshi",
"Affiliation": "Third Department of Internal Medicine, Second Hospital of Yuhang District of Hangzhou 311121, China."
},
{
"LastName": "Wei",
"FirstName": "Bing",
"Affiliation": "Department of Pediatrics, General Hospital of Shenyang Military Area Command Shenyang 110016, China."
}
] |
No
|
35421141
|
Integrated use of phosphorus, farmyard manure and biofertilizer improves the yield and phosphorus uptake of black gram in silt loam soil.
|
An experiment on the use of farmyard manure and biofertilizer along with application of chemical phosphorus was conducted to assess the impact of differential doses of phosphorus, farmyard manure and consortium biofertilizer application on the development, yield and phosphorus uptake during the year 2018 and 2019. The impact of different treatments was recorded on the plant height, dry matter partition, yield and yield attributes, phosphorus uptake and soil phosphorus availability using standard methods. The data revealed significant improvement in yield, yield attributes, phosphorus uptake and soil phosphorus availability. The integration of farmyard manure and biofertilizer with 60 kg ha-1 SSP (single superphosphate) has improved the black gram yield by 7.4% and 3.28% respectively over the use of 60 SSP alone. The phosphorus uptake in black gram with application of Farm yard manure and biofertilizer along with 60 kg ha-1 SSP has improved the uptake by 7.18% and 2.51% respectively over the use of 60 kg ha-1 SSP alone. The results highlight the need of integrated application of farm yard manure, biofertilizer for sustainable production of black gram in the region.
|
2022
|
PloS one
|
No DOI
|
[
{
"LastName": "Singh",
"FirstName": "Jagdish",
"Affiliation": "Punjab Agricultural University Regional Research Station, Gurdaspur, Punjab, India."
},
{
"LastName": "Bhatt",
"FirstName": "Rajan",
"Affiliation": "Punjab Agricultural University Regional Research Station, Kapurthala, Punjab, India."
},
{
"LastName": "S",
"FirstName": "Dhaliwal S",
"Affiliation": "Department of Soil Science, Punjab Agricultural University Ludhiana, Punjab, India."
},
{
"LastName": "Dhillon",
"FirstName": "B S",
"Affiliation": "Punjab Agricultural University Regional Research Station, Gurdaspur, Punjab, India."
},
{
"LastName": "Al-Huqail",
"FirstName": "Asma A",
"Affiliation": "Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia."
},
{
"LastName": "Alfagham",
"FirstName": "Alanoud",
"Affiliation": "Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia."
},
{
"LastName": "Siddiqui",
"FirstName": "Manzer H",
"Affiliation": "Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia."
},
{
"LastName": "Ali",
"FirstName": "Hayssam M",
"Affiliation": "Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia."
},
{
"LastName": "Khan",
"FirstName": "Faheema",
"Affiliation": "Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia."
},
{
"LastName": "Kumar",
"FirstName": "Ritesh",
"Affiliation": "Department of Agronomy, Kansas State University, Manhattan, KS, United States of America."
}
] |
Yes
|
22926926
|
Apicidin induces endoplasmic reticulum stress- and mitochondrial dysfunction-associated apoptosis via phospholipase Cγ1- and Ca(2+)-dependent pathway in mouse Neuro-2a neuroblastoma cells.
|
Apicidin, a fungal metabolite that functions as a histone deacetylase inhibitor, induces apoptosis in cancer cells. We investigated the molecular mechanisms of the anti-cancer effects of apicidin in mouse Neuro-2a neuroblastoma cells. Apicidin induced apoptotic cell death and activation of caspase-12, -9, and -3. Apicidin induced expression of endoplasmic reticulum (ER) stress-associated proteins, including CCAAT/enhancer binding protein homologous protein (CHOP), cleavage of activating transcription factor 6α, and phosphorylation of eukaryotic initiation factor 2α. Inhibition of ER stress by CHOP knockdown or using the ER stress inhibitors, salubrinal and 4-phenylbutyric acid, reduced apicidin-induced cell death. Apicidin induced reactive oxygen species accumulation and mitochondrial membrane potential loss. An antioxidant, N-acetyl cysteine, reduced apicidin-induced cell death, CHOP expression, and mitochondrial dysfunction. In addition, apicidin increased cytosolic Ca(2+), which was blocked by 2-aminoethoxydiphenyl borate, an antagonist of inositol 1,4,5-trisphosphate receptor, and BAPTA-AM, an intracellular Ca(2+) chelator. 2-Aminoethoxydiphenyl borate and BAPTA-AM inhibited apicidin-induced cell death and ER stress. Interestingly, apicidin induced phosphorylation of phospholipase Cγ1 (PLCγ1) and epidermal growth factor receptor (EGFR), and inhibition of PLCγ1 and EGFR reduced cell death and ER stress. Finally, apicidin-induced histone H3 hyperacetylation and reduction of histone deacetylase 2 mRNA expression were not affected by either a PLCγ1 inhibitor, U73122, or the antioxidant, N-acetyl cysteine. Taken together, the results suggest that apicidin induces apoptosis by ER stress and mitochondrial dysfunction via PLCγ1 activation, Ca(2+) release, and reactive oxygen species accumulation in Neuro-2a neuroblastoma cells.
|
2012 Dec
|
Apoptosis : an international journal on programmed cell death
|
No DOI
|
[
{
"LastName": "Choi",
"FirstName": "Ji Hyun",
"Affiliation": "Department of Biochemistry and Molecular Biology, School of Medicine, Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul 130-701, Republic of Korea."
},
{
"LastName": "Lee",
"FirstName": "Jung Yeon",
"Affiliation": ""
},
{
"LastName": "Choi",
"FirstName": "A-Young",
"Affiliation": ""
},
{
"LastName": "Hwang",
"FirstName": "Keun-Young",
"Affiliation": ""
},
{
"LastName": "Choe",
"FirstName": "Wonchae",
"Affiliation": ""
},
{
"LastName": "Yoon",
"FirstName": "Kyung-Sik",
"Affiliation": ""
},
{
"LastName": "Ha",
"FirstName": "Joohun",
"Affiliation": ""
},
{
"LastName": "Yeo",
"FirstName": "Eui-Ju",
"Affiliation": ""
},
{
"LastName": "Kang",
"FirstName": "Insug",
"Affiliation": ""
}
] |
Yes
|
30706412
|
Quantification of Tyrosine Hydroxylase and ErbB4 in the Locus Coeruleus of Mood Disorder Patients Using a Multispectral Method to Prevent Interference with Immunocytochemical Signals by Neuromelanin.
|
The locus coeruleus (LC) has been studied in major depressive disorder (MDD) and bipolar disorder (BD). A major problem of immunocytochemical studies in the human LC is interference with the staining of the immunocytochemical end-product by the omnipresent natural brown pigment neuromelanin. Here, we used a multispectral method to untangle the two colors: blue immunocytochemical staining and brown neuromelanin. We found significantly increased tyrosine hydroxylase (TH) in the LC of MDD patients-thus validating the method-but not in BD patients, and we did not find significant changes in the receptor tyrosine-protein kinase ErbB4 in the LC in MDD or BD patients. We observed clear co-localization of ErbB4, TH, and neuromelanin in the LC neurons. The different stress-related molecular changes in the LC may contribute to the different clinical symptoms in MDD and BD.
|
2019 Apr
|
Neuroscience bulletin
|
No DOI
|
[
{
"LastName": "Guo",
"FirstName": "Lei",
"Affiliation": "Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China."
},
{
"LastName": "Stormmesand",
"FirstName": "Jochem",
"Affiliation": "Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, 1105 BA, the Netherlands."
},
{
"LastName": "Fang",
"FirstName": "Zheng",
"Affiliation": "Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China."
},
{
"LastName": "Zhu",
"FirstName": "Qingbin",
"Affiliation": "Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China."
},
{
"LastName": "Balesar",
"FirstName": "Rawien",
"Affiliation": "Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, 1105 BA, the Netherlands."
},
{
"LastName": "van Heerikhuize",
"FirstName": "Joop",
"Affiliation": "Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, 1105 BA, the Netherlands."
},
{
"LastName": "Sluiter",
"FirstName": "Arja",
"Affiliation": "Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, 1105 BA, the Netherlands."
},
{
"LastName": "Swaab",
"FirstName": "Dick",
"Affiliation": "Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, 1105 BA, the Netherlands."
},
{
"LastName": "Bao",
"FirstName": "Ai-Min",
"Affiliation": "Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China. [email protected]."
}
] |
No
|
20103843
|
Two evolutionarily conserved essential beta-barrel proteins in the chloroplast outer envelope membrane.
|
Chloroplasts are organelles specific to photosynthetic eukaryotes that support the lives of most organisms on earth. Chloroplasts were derived from an ancient cyanobacterium by endosymbiosis, and one characteristic shared between them and extant cyanobacteria is the presence of beta-barrel proteins in the outer membrane. These integral membrane proteins are also found in the outer membranes of proteobacteria and mitochondria. In particular, a group of homologous beta-barrel proteins called BamA homologs are present in all Gram-negative bacteria and the endosymbiotic organelles, i.e., chloroplasts and mitochondria. It was recently revealed that, in both proteobacteria and mitochondria, there is a single essential BamA homolog that mediates beta-barrel protein assembly. In a chloroplast, there are two distinct BamA homologs, Toc75 and OEP80, which diverged early in the evolution of chloroplasts from their common ancestor with extant cyanobacteria. Recent genetic studies demonstrated that each of these proteins is indispensable for viability of plants although neither has been shown to be involved in beta-barrel protein assembly. Toc75 catalyzes import of nuclear-encoded precursor proteins, a process that is not required for bacteria, whereas the molecular function of OEP80 remains elusive. Establishment of a protein import apparatus was required to facilitate the transfer of genes from the endosymbiont to the host cell nucleus. Hence, we propose that the gene duplication giving rise to the two essential BamA homologs was a prerequisite for the successful conversion of the cyanobacterial endosymbiont into the chloroplast. Consequently, continued study of these two chloroplast proteins should advance our understanding of endosymbiosis and evolutionarily conserved proteins in general.
|
2009 Oct
|
Bioscience trends
|
No DOI
|
[
{
"LastName": "Hsu",
"FirstName": "Shih-Chi",
"Affiliation": "Department of Plant Sciences, University of California, Davis, CA 95616, USA."
},
{
"LastName": "Inoue",
"FirstName": "Kentaro",
"Affiliation": ""
}
] |
No
|
33586862
|
Biomechanics of juvenile tyrannosaurid mandibles and their implications for bite force: Evolutionary biology.
|
The tyrannosaurids are among the most well-studied dinosaurs described by science, and analysis of their feeding biomechanics allows for comparison between established tyrannosaurid genera and across ontogeny. 3D finite element analysis (FEA) was used to model and quantify the mechanical properties of the mandibles (lower jaws) of three tyrannosaurine tyrannosaurids of different sizes. To increase evolutionary scope and context for 3D tyrannosaurine results, a broader sample of validated 2D mandible FEA enabled comparisons between ontogenetic stages of Tyrannosaurus rex and other large theropods. It was found that mandibles of small juvenile and large subadult tyrannosaurs experienced lower stress overall because muscle forces were relatively lower, but experienced greater simulated stresses at decreasing sizes when specimen muscle force is normalized. The strain on post-dentary ligaments decreases stress and strain in the posterior region of the dentary and where teeth impacted food. Tension from the lateral insertion of the looping m. ventral pterygoid muscle increases compressive stress on the angular but may decrease anterior bending stress on the mandible. Low mid-mandible bending stresses are congruent with ultra-robust teeth and high anterior bite force in adult T. rex. Mandible strength increases with size through ontogeny in T. rex and phylogenetically among other tyrannosaurids, in addition to that tyrannosaurid mandibles exceed the mandible strength of other theropods at equivalent ramus length. These results may indicate separate predatory strategies used by juvenile and mature tyrannosaurids; juvenile tyrannosaurids lacked the bone-crunching bite of adult specimens and hunted smaller prey, while adult tyrannosaurids fed on larger prey.
|
2022 Feb
|
Anatomical record (Hoboken, N.J. : 2007)
|
No DOI
|
[
{
"LastName": "Rowe",
"FirstName": "Andre J",
"Affiliation": "School of Earth Sciences, University of Bristol, Bristol, United Kingdom."
},
{
"LastName": "Snively",
"FirstName": "Eric",
"Affiliation": "College of Osteopathic Medicine, Oklahoma State University, Tulsa, Oklahoma, USA."
}
] |
No
|
38868114
|
Intrarenal epidermoid cyst mimicking a cystic renal cell carcinoma: A case report and review of literature.
|
This case highlights the diagnostic pitfalls that can occur when evaluating complex cystic renal masses. Distinguishing epidermoid cysts from renal cell carcinoma is difficult but imperative to guide conservative management when appropriate, avoiding unnecessary nephrectomy. Renal epidermoid cysts are extremely rare, with only 12 cases reported in the literature. Their radiographic features often resemble cystic renal cell carcinoma, frequently prompting unnecessary nephrectomy. A 64-year-old man with a history of nephrolithiasis presented with left flank pain and hematuria. Imaging revealed a complex cystic renal mass suspicious for renal cell carcinoma. Following left radical nephrectomy, histopathology examination revealed a benign epidermoid cyst. Renal presentation of epidermoid cyst poses unique diagnostic and therapeutic challenges. Possible pathogenesis includes ectopic epidermal implantation during embryogenesis or squamous metaplasia following chronic irritation or deficiency. Radiographic distinction from concerning entities like renal cell carcinoma is difficult but imperative to avoid extensive surgery. This case highlights the diagnostic pitfalls and management considerations for renal epidermoid cysts. Additional study of clinical and imaging factors that distinguish epidermoid cysts from renal cell carcinoma can guide conservative management when appropriate, avoiding unnecessary nephrectomy for benign disease.
|
2024 Jun
|
Clinical case reports
|
No DOI
|
[
{
"LastName": "Khorraminejad-Shirazi",
"FirstName": "Mohammadhossein",
"Affiliation": "Department of Pathology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran."
},
{
"LastName": "Nabavizadeh",
"FirstName": "Seyed Ali",
"Affiliation": "Department of Otolaryngology, Otolaryngology Research Center Shiraz University of Medical Sciences Shiraz Iran."
},
{
"LastName": "Shirazi Yeganeh",
"FirstName": "Babak",
"Affiliation": "Department of Pathology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran."
},
{
"LastName": "Ahmadifar",
"FirstName": "Maryam",
"Affiliation": "Department of Pathology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran."
},
{
"LastName": "Salehipour",
"FirstName": "Mehdi",
"Affiliation": "Department of Urology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran."
},
{
"LastName": "Jafari",
"FirstName": "Seyed Hamed",
"Affiliation": "Medical Imaging Research Center Shiraz University of Medical Sciences Shiraz Iran."
},
{
"LastName": "Omidifar",
"FirstName": "Navid",
"Affiliation": "Department of Pathology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran."
}
] |
No
|
23755747
|
A roadmap for fever of unknown origin in children.
|
Fever of unknown origin (FUO) in adults is conventionally defined by the occurrence of body temperatures above 38.3 degrees C (101 degrees F) for a period of 3 weeks without any identified etiology after a period of 1-week hospitalization. The issue of FUO in pediatrics is rather hazy and still represents a challenging diagnostic dilemma. Most of the available data are limited to nationwide cohorts of patients of any age. The major difficulty in establishing a diagnosis is that the characteristic features rendering specific disorders clinically recognizable are absent or subtle, hence only a painstaking questioning on family background may elicit the correct investigative path. No diagnostic algorithms are actually available and clinicians must rely on a very careful step-by-step evaluation of the single patient. The need for invasive diagnostic techniques should be closely taken into consideration when laboratory tests or simple imaging procedures fail to discern the origin of FUO. Fevers with no reasonable explanation and no localizing signs often conceal different common diseases in children, which tend to display an unusual or atypical pattern. The principal causes behind FUO in pediatric age remain infections, followed by collagen vascular diseases and neoplastic disorders, although most children with malignancies present other systemic signs or suggestive laboratory abnormalities. The possibility of autoinflammatory syndromes, drug fever, and factitious fever should also be taken into account.
|
2013 Apr-Jun
|
International journal of immunopathology and pharmacology
|
No DOI
|
[
{
"LastName": "Rigante",
"FirstName": "D",
"Affiliation": "Institute of Pediatrics, Universita' Cattolica Sacro Cuore, Rome, Italy."
},
{
"LastName": "Esposito",
"FirstName": "S",
"Affiliation": ""
}
] |
No
|
29384222
|
RNA interference-mediated silencing of S100B improves nerve function recovery and inhibits hippocampal cell apoptosis in rat models of ischemic stroke.
|
Ischemic stroke is the leading cause of worldwide mortality and long-term disability in adults. This study aims to explore the effects of RNA interference (RNAi)-mediated silencing of the S100B gene on nerve function recovery and morphological changes of hippocampus cells in rat models with ischemic stroke. Sixty Wistar rats were assigned into different group. S100B and Caspase 3 mRNA and protein expressions were evaluated by RT-qPCR and Western blotting. Positive rate of S100B, NeuN, and MAP2 expressions were detected by immunohistochemistry (IHC). Water content, malondialdehyde (MDA) levels, and superoxide dismutase (SOD) activity in brain tissues were measured. Enzyme-linked immunosorbent assay (ELISA) was employed to detect serum levels of TNF-α and IL-1β. A neurological severity score (NSS) was used to test nerve function. TUNEL assay was used to determine hippocampal cell apoptosis. Downregulation of S100B showed a lower number of S100B immune positive cells, but higher NeuN and MAP2-positive cells, increased SOD level, declined MDA level, prominently faster recovery of neurological function, decreased TRCS, TCTP, TCFP, and IE levels, an obvious increase in the number of survival neurons, a decrease in the number of apoptotic cells, notably decreased TNF-α and IL-1β contents, as well as infarct volume, an obvious decrease in positive hippocampal cell Caspase 3 expression and protein expressions of Caspase 3 and cleaved Caspase 3. This study provides data to suggest that RNAi-mediated silencing of S100B gene could improve the recovery of nerve function while inhibiting apoptosis of hippocampal cells in rats with ischemic stroke.
|
2018 Nov
|
Journal of cellular biochemistry
|
No DOI
|
[
{
"LastName": "Zhang",
"FirstName": "Jin-Hua",
"Affiliation": "Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China."
},
{
"LastName": "Li",
"FirstName": "Jiang-Kun",
"Affiliation": "Department of Neurology, Kaifeng Central Hospital, Kaifeng, P.R. China."
},
{
"LastName": "Ma",
"FirstName": "Li-Li",
"Affiliation": "Department of Neurology, Kaifeng Central Hospital, Kaifeng, P.R. China."
},
{
"LastName": "Lou",
"FirstName": "Ji-Yu",
"Affiliation": "Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China."
}
] |
Yes
|
28065169
|
CHANGING HEALTH TECHNOLOGY ASSESSMENT PARADIGMS?-ERRATUM.
|
In Husereau et al., the affiliation for Laura Sampietro-Colom was listed as "Hospital Clinic". It should have instead been listed as, "Hospital Clinic, Barcelona, Spain".
|
2016 Jan
|
International journal of technology assessment in health care
|
No DOI
|
[
{
"LastName": "Husereau",
"FirstName": "Don",
"Affiliation": ""
},
{
"LastName": "Henshall",
"FirstName": "Chris",
"Affiliation": ""
},
{
"LastName": "Sampietro-Colom",
"FirstName": "Laura",
"Affiliation": ""
},
{
"LastName": "Thomas",
"FirstName": "Sarah",
"Affiliation": ""
}
] |
No
|
17060983
|
Houston biosecurity: building a national model.
|
On September 11, 2001, Al Qaeda terrorists committed an atrocity when they used domestic jetliners to crash into buildings in New York City and Washington, DC, killing thousands of people. In October 2001, another act of savagery occurred, this time using anthrax, not airplanes, to take innocent lives. Each incident demonstrates the vulnerability of an open society, and Americans are left to wonder how such acts can be prevented. Two years later, Al Qaeda operatives are reportedly regrouping, recruiting, and changing their tactics to distribute money and messages to operatives around the world. Many experts believe that terrorist attacks are inevitable. Every city is vulnerable to an attack, and none are fully prepared to handle the residual impact of a biological or chemical attack. A survey conducted by the Cable News Network (CNN) in January 2002, studied 30 major US cities, ranking them based on 6 statistical indices of vulnerability. Thirteen cities were deemed better prepared than Houston, 10 were in a similar state of preparedness, and only 6 were less prepared than Houston. We will discuss the protective measures that have been put in place in Houston, and future steps to take. Other cities can model Houston's experience to develop similar plans nation-wide.
|
2004
|
Transactions of the American Clinical and Climatological Association
|
No DOI
|
[
{
"LastName": "Casscells",
"FirstName": "Ward",
"Affiliation": "President Bush Center for Cardiovascular Health, Hermann Hospital, Houston, Texas, USA."
},
{
"LastName": "Mirhaji",
"FirstName": "Parsa",
"Affiliation": ""
},
{
"LastName": "Lillibridge",
"FirstName": "Scott",
"Affiliation": ""
},
{
"LastName": "Madjid",
"FirstName": "Mohammad",
"Affiliation": ""
}
] |
No
|
38687049
|
Multi-omics analysis reveals the association between specific solute carrier proteins gene expression patterns and the immune suppressive microenvironment in glioma.
|
Glioma is the most prevalent malignant brain tumour. Currently, reshaping its tumour microenvironment has emerged as an appealing strategy to enhance therapeutic efficacy. As the largest group of transmembrane transport proteins, solute carrier proteins (SLCs) are responsible for the transmembrane transport of various metabolites and ions. They play a crucial role in regulating the metabolism and functions of malignant cells and immune cells within the tumour microenvironment, making them a promising target in cancer therapy. Through multidimensional data analysis and experimental validation, we investigated the genetic landscape of SLCs in glioma. We established a classification system comprising 7-SLCs to predict the prognosis of glioma patients and their potential responses to immunotherapy and chemotherapy. Our findings unveiled specific SLC expression patterns and their correlation with the immune-suppressive microenvironment and metabolic status. The 7-SLC classification system was validated in distinguishing subgroups within the microenvironment, specifically identifying subsets involving malignant cells and tumour-associated macrophages. Furthermore, the orphan protein SLC43A3, a core member of the 7-SLC classification system, was identified as a key facilitator of tumour cell proliferation and migration, suggesting its potential as a novel target for cancer therapy.
|
2024 May
|
Journal of cellular and molecular medicine
|
No DOI
|
[
{
"LastName": "Wu",
"FirstName": "Wenjie",
"Affiliation": "Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."
},
{
"LastName": "Jiang",
"FirstName": "Cheng",
"Affiliation": "Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."
},
{
"LastName": "Zhu",
"FirstName": "Wende",
"Affiliation": "Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."
},
{
"LastName": "Jiang",
"FirstName": "Xiaobing",
"Affiliation": "Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."
}
] |
No
|
17208720
|
Beyond trade: taking globalization to the health sector.
|
The pace of globalization has brought the world to the brink of a new era in international relations. While the world has outgrown traditional mechanisms for addressing global issues, it has not yet developed new forms of effective governance. This temporary void poses threats and enormous opportunities. The public health sector will play a crucial "formal" role--that is, carried out by existing bodies such as WHO and the UN. But WHO does not necessarily represent the full spectrum of views and its members necessarily work, to some degree, for separate national interests. The formal dimension must be supplemented. Globalization is not synonymous with lack of regulation. Many responsible businesses would welcome a transparent and universally applied regulatory regime to prevent a race to the lowest standards. The economic benefits of globalization may hit a glass ceiling if societies outside the global economy become progressively poorer and less healthy. The business community is recognizing that good health is essential for economic growth and social stability. Globalization may cause millions to migrate for economic opportunity. The private sector's forward-thinkers recognize the health threats of migration and are beginning to view global health promotion as a means to ensure optimal market access.
|
2003
|
New solutions : a journal of environmental and occupational health policy : NS
|
No DOI
|
[
{
"LastName": "Daulaire",
"FirstName": "Nils",
"Affiliation": "Global Health Council, White River Junction, VT 05001, USA. [email protected]"
}
] |
No
|
36743462
|
Systematically Investigating the Pharmacological Mechanism of Momordica grosvenori in the Treatment of Spinal Cord Injury by Network Pharmacology and Experimental Verification.
|
This study aimed to explore the molecular mechanism of Momordica grosvenori (MG) in spinal cord injury (SCI) by network pharmacology analysis. We searched for potential active MG compounds using the TCMSP database and the BATMAN-TCM platform. The Swiss target prediction database was used to find MG-related targets and the targets of SCI from the CTD, GeneCards, and DrugBank databases. Following that, a protein-protein interaction (PPI) study was carried out. Cytoscape software was used to calculate the hub gene, and R software was used to evaluate the Gene Ontology (GO) and KEGG enrichment pathways. Finally, molecular docking between the hub protein and important compounds was performed. We verified STAT3, MAPK1, HSP90AA1, PIK3R1, PIK3CA, and RXRA potential targets by quantitative PCR. We obtained 293 MG-anti-SCI targets with potential therapeutic utility by intersecting 346 MG-related targets and 7214 SCI-related targets. The top 10 identified genes, ranking in descending order of value, were SRC, STAT3, MAPK1, HSP90AA1, PIK3R1, PIK3CA, RXRA, AKT1, CREBBP, and JAK2. Through enrichment analysis and literature search, 10 signaling pathways were screened out. The molecular docking of important drugs and hub targets revealed that some had a higher binding affinity. The results of quantitative PCR indicated that MAPK1, RXRA, and STAT3 were expressed differently in in vitro experiments. In conclusion, the current work indicated that MG might play an anti-SCI role via multicomponent, multitarget, and multichannel interaction, which presents a novel idea for further research into the precise mechanism of MG-anti-SCI interaction.
|
2023
|
Evidence-based complementary and alternative medicine : eCAM
|
No DOI
|
[
{
"LastName": "Wang",
"FirstName": "Jiling",
"Affiliation": "The First Clinical Medical College of Guangxi Medical University, Nanning, China."
},
{
"LastName": "Yang",
"FirstName": "Zihong",
"Affiliation": "The Second Affiliated Hospital of Guangxi Medical University, Nanning, China."
},
{
"LastName": "Jiang",
"FirstName": "Jie",
"Affiliation": "The Second Affiliated Hospital of Guangxi Medical University, Nanning, China."
},
{
"LastName": "Xv",
"FirstName": "Yang",
"Affiliation": "The First Affiliated Hospital of Guangxi Medical University, Nanning, China."
},
{
"LastName": "Tan",
"FirstName": "Xiuwei",
"Affiliation": "The First Clinical Medical College of Guangxi Medical University, Nanning, China."
},
{
"LastName": "Chen",
"FirstName": "Ruyu",
"Affiliation": "The First Affiliated Hospital of Guangxi Medical University, Nanning, China."
},
{
"LastName": "Li",
"FirstName": "Fengxin",
"Affiliation": "The First Affiliated Hospital of Guangxi Medical University, Nanning, China."
},
{
"LastName": "Li",
"FirstName": "Changqiu",
"Affiliation": "The First Affiliated Hospital of Guangxi Medical University, Nanning, China."
},
{
"LastName": "Su",
"FirstName": "Yiji",
"Affiliation": "The First Affiliated Hospital of Guangxi Medical University, Nanning, China."
}
] |
No
|
34484859
|
m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling.
|
Pancreatic cancer is the deadliest malignancy of the digestive system and is the seventh most common cause of cancer-related deaths worldwide. The incidence and mortality of pancreatic cancer continue to increase, and its 5-year survival rate remains the lowest among all cancers. N6-methyladenine (m6A) is the most abundant reversible RNA modification in various eukaryotic messenger and long noncoding RNAs and plays crucial roles in the occurrence and development of cancers. However, the role of m6A in pancreatic cancer remains unclear. The present study aimed to explore the role of m6A and its regulators in pancreatic cancer and assess its underlying molecular mechanism associated with pancreatic cancer cell proliferation, invasion, and metastasis. Reduced expression of the m6A demethylase, fat mass and obesity-associated protein (FTO), was responsible for the high levels of m6A RNA modification in pancreatic cancer. Moreover, FTO demethylated the m6A modification of praja ring finger ubiquitin ligase 2 (PJA2), thereby reducing its mRNA decay, suppressing Wnt signaling, and ultimately restraining the proliferation, invasion, and metastasis of pancreatic cancer cells. Altogether, this study describes new, potential molecular therapeutic targets for pancreatic cancer that could pave the way to improve patient outcome.
|
2021 Sep 3
|
Molecular therapy. Nucleic acids
|
No DOI
|
[
{
"LastName": "Zeng",
"FirstName": "Juan",
"Affiliation": "Department of Oncology, Shengjing Hospital of China Medical University, Shenyang Liaoning 110004, China."
},
{
"LastName": "Zhang",
"FirstName": "Heying",
"Affiliation": "Department of Oncology, Shengjing Hospital of China Medical University, Shenyang Liaoning 110004, China."
},
{
"LastName": "Tan",
"FirstName": "Yonggang",
"Affiliation": "Department of Oncology, Shengjing Hospital of China Medical University, Shenyang Liaoning 110004, China."
},
{
"LastName": "Wang",
"FirstName": "Zhe",
"Affiliation": "Department of Pathology, Shengjing Hospital of China Medical University, Shenyang Liaoning 110004, China."
},
{
"LastName": "Li",
"FirstName": "Yunwei",
"Affiliation": "Department of Pathology, Shengjing Hospital of China Medical University, Shenyang Liaoning 110004, China."
},
{
"LastName": "Yang",
"FirstName": "Xianghong",
"Affiliation": "Department of Pathology, Shengjing Hospital of China Medical University, Shenyang Liaoning 110004, China."
}
] |
Yes
|
36045948
|
Analysis of Efficacy, Complications, and Inflammatory Reactions of Bridge Combined Internal Fixation System for Periarticular Fractures of the Shoulder.
|
The aim of the present research is to analyze the impact of the bridge combined internal fixation system (BCFS) on efficacy, complications, and inflammatory reactions of periarticular fractures of the shoulder. A retrospective analysis was performed on 100 patients with periarticular fractures of the shoulder admitted between January 2016 and January 2020. Patients were assigned to the observation group (OG) and control group (CG) according to different treatment schemes, with 50 cases in each group. Patients in OG were intervened by BCFS, while those in CG were routinely given plate fixation. The treatment outcome, complications, and inflammatory reaction of the two groups were compared. The results showed better treatment outcome, shoulder joint function recovery, and inflammatory reaction alleviation of OG compared with CG. Besides, statistically shorter fracture healing and hospitalization time as well as fewer complications were determined in OG. These results demonstrate that compared with the plate fixation system, BCFS can significantly improve the surgical efficacy and healing efficiency and alleviate the inflammatory response of patients, with a low complication rate, all of which contribute to faster recovery of periarticular fractures of the shoulder. Hence, BCFS is an ideal choice for periarticular fractures of the shoulder that deserves clinical promotion.
|
2022
|
Computational and mathematical methods in medicine
|
No DOI
|
[
{
"LastName": "Xu",
"FirstName": "Haiyun",
"Affiliation": "Department of Orthopedics, The Fourth People's Hospital of Changzhou, Changzhou, 213100 Jiangsu, China."
},
{
"LastName": "Fan",
"FirstName": "Youliang",
"Affiliation": "Department of Orthopedics, The Fourth People's Hospital of Changzhou, Changzhou, 213100 Jiangsu, China."
},
{
"LastName": "Lu",
"FirstName": "Jiajun",
"Affiliation": "Department of Orthopedics, The Fourth People's Hospital of Changzhou, Changzhou, 213100 Jiangsu, China."
},
{
"LastName": "Wu",
"FirstName": "Yixiong",
"Affiliation": "Department of Orthopedics, The Fourth People's Hospital of Changzhou, Changzhou, 213100 Jiangsu, China."
},
{
"LastName": "Feng",
"FirstName": "Xiaoguang",
"Affiliation": "Department of Orthopedics, The Fourth People's Hospital of Changzhou, Changzhou, 213100 Jiangsu, China."
}
] |
Yes
|
34405166
|
Tackling COVID-19 in informal tented settlements (Lebanon): An assessment of preparedness and response plans and their impact on the health vulnerabilities of Syrian refugees.
|
This paper is exploring and critically accessing the nature and mechanisms of preparedness and response plans to COVID-19 in Syrian ITSs in Lebanon along with their immediate health impacts on refugees and their abilities to survive. Little is known to date about how such plans have been set up and how they have immediately impacted refugees, particularly those in countries affected by severe economic and political turbulences along with fragile health systems. This qualitative study has been conducted during the pandemic and hence is providing important and novel insights into a time-limited research window during which not only refugees' mobility was restricted but also research capabilities severely constrained. We are focusing on the relationships between refugees, health and the COVID-19 pandemic and unwrapping how very strict and control-led preventive mechanisms have emerged as a consequence of already stretched and problematic health and socio-economic systems. We are also demonstrating how the multi-level strategy and local responses have led to significant challenges to local municipalities, local NGOs and international aid agencies in order to reduce transmission risks in very unhealthy settings as they try to address wider needs. This paper concludes that the impact of the constraining preventive measures implemented to date means that refugee communities will suffer consequences for months and years to come, with their ability to survive being threatened and an expected long-term health impact for a population already at high risk of NCDs. We argue that more research will be needed into deconstructing further refugees' reactions to encampment mechanisms and mobility restrictions, particularly if survival becomes even more problematic; similarly relationships and tensions with local municipalities, as well as measures and support provided by local and international NGOs, will deserve attention. A key question remains about the likely scenario if cases start to spread widely in ITSs and, hence, what will happen to both refugees and host communities in a country with a health system on the edge of collapse.
|
2020
|
Journal of migration and health
|
No DOI
|
[
{
"LastName": "Moawad",
"FirstName": "Paul",
"Affiliation": "Bartlett School of Planning, UCL Faculty of the Built Environment, University College London, Central House, 14 Upper Woburn Place, London WC1h 0NN, United Kingdom."
},
{
"LastName": "Andres",
"FirstName": "Lauren",
"Affiliation": "Bartlett School of Planning, UCL Faculty of the Built Environment, University College London, Central House, 14 Upper Woburn Place, London WC1h 0NN, United Kingdom."
}
] |
No
|
29957737
|
Case Series: Corneal Epithelial Macrocysts in Scleral Contact Lenses Post-penetrating Keratoplasty.
|
Transitory corneal epithelial macrocysts associated with scleral contact lens wear post-penetrating keratoplasty are observed in areas of corneal edema. The macrocysts do not appear to result in complications that would prevent successful wear of scleral contact lenses. The purpose of this study is to report three cases of transitory corneal epithelial macrocysts associated with scleral lenses in post-penetrating keratoplasty corneas. Three cases including anterior segment photographs and anterior segment optical coherence tomography highlight the clinical presentation of transient corneal epithelial macrocysts. Corneal edema and anatomical alterations after penetrating keratoplasty along with the negative pressure underneath a scleral contact lens are hypothesized to have caused the transient epithelial macrocysts observed in these cases. Because of the transitory nature of these cysts without evidence of consequent corneal damage or cyst rupture over years of observance, we believe that it is safe for these patients to continue wearing scleral contact lenses with routine follow-up.
|
2018 Jul
|
Optometry and vision science : official publication of the American Academy of Optometry
|
No DOI
|
[
{
"LastName": "Nguyen",
"FirstName": "Linda Trang",
"Affiliation": ""
},
{
"LastName": "Yang",
"FirstName": "David",
"Affiliation": "Veterans Affairs Palo Alto Health Care System, Palo Alto, California *[email protected]."
},
{
"LastName": "Vien",
"FirstName": "Lee",
"Affiliation": "Veterans Affairs Palo Alto Health Care System, Palo Alto, California *[email protected]."
}
] |
No
|
38915213
|
A systematic review of the role of TREM2 in Alzheimer's disease.
|
Given the established genetic linkage between triggering receptors expressed on myeloid cells 2 (TREM2) and Alzheimer's disease (AD), an expanding research body has delved into the intricate role of TREM2 within the AD context. However, a conflicting landscape of outcomes has emerged from both in vivo and in vitro investigations. This study aimed to elucidate the multifaceted nuances and gain a clearer comprehension of the role of TREM2. PubMed database was searched spanning from its inception to January 2022. The search criteria took the form of ("Alzheimer's disease" OR "AD") AND ("transgenic mice model" OR "transgenic mouse model") AND ("Triggering receptor expressed on myeloid cells" OR "TREM2"). Inclusion criteria consisted of the following: (1) publication of original studies in English; (2) utilization of transgenic mouse models for AD research; and (3) reports addressing the subject of TREM2. A total of 43 eligible articles were identified. Our analysis addresses four pivotal queries concerning the interrelation of TREM2 with microglial function, Aβ accumulation, tau pathology, and inflammatory processes. However, the diverse inquiries posed yielded inconsistent responses. Nevertheless, the inconsistent roles of TREM2 within these AD mouse models potentially hinge upon factors such as age, sex, brain region, model type, and detection methodologies. This review substantiates the evolving understanding of TREM2's disease progression-dependent impacts. Furthermore, it reviews the interplay between TREM2 and its effects across diverse tissues and temporal stages.
|
2024 Jul 20
|
Chinese medical journal
|
No DOI
|
[
{
"LastName": "Yin",
"FirstName": "Yunsi",
"Affiliation": "Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing 100053, China."
},
{
"LastName": "Yang",
"FirstName": "Hanchen",
"Affiliation": ""
},
{
"LastName": "Li",
"FirstName": "Ruiyang",
"Affiliation": ""
},
{
"LastName": "Wu",
"FirstName": "Guangshan",
"Affiliation": ""
},
{
"LastName": "Qin",
"FirstName": "Qi",
"Affiliation": ""
},
{
"LastName": "Tang",
"FirstName": "Yi",
"Affiliation": ""
}
] |
No
|
24639872
|
Synthesis of 6-(2-Methoxynaphthyl)-2,3-dihydro-1,2,4-triazine-3-thione as a New Reagent for Spectrophotometric Determination of Copper.
|
A simple, sensitive, accurate, and green spectrophotometric method for the determination of Cu(II) using newly synthesized reagent, 6-(2-methoxynaphthyl)-2,3-dihydro-1,2,4-triazine-3-thione (MNDTT), has been developed. MNDTT was synthesized based on the acylation of methoxy naphthalene and reaction of the product with amyl nitrite, which upon reaction with thiosemicarbazide yielded 6-(2-meyhoxynaphthyl)-2,3-dihydro-1,2,4-triazine-3-thione. MNDTT produces a dark red complex with copper in methanol according to the 1 : 2 stoichiometry. Beer's law was obeyed over the concentration range of 2.5-20 µg/mL with r (2) = 0.992. The limit of detection and limit of quantification were 0.33 and 1.10 µg/mL, respectively. Within-day and between-day precision values were less than 3.68%. Finally, the method has been applied to a dental alloy (110-plus) successfully and the results were compared with atomic absorption method. The results showed that there was no significant difference between the two methods (P > 0.05).
|
2014
|
International journal of analytical chemistry
|
No DOI
|
[
{
"LastName": "Barazandeh Tehrani",
"FirstName": "Maliheh",
"Affiliation": "Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Science Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran."
},
{
"LastName": "Ghanbari",
"FirstName": "Hutan",
"Affiliation": "Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Science Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran."
},
{
"LastName": "Souri",
"FirstName": "Effat",
"Affiliation": "Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Science Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran."
},
{
"LastName": "Shamsa",
"FirstName": "Fazel",
"Affiliation": "Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Science Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran."
},
{
"LastName": "Amini",
"FirstName": "Mohsen",
"Affiliation": "Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Science Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran."
}
] |
No
|
33570485
|
Comparison of drug-susceptibility patterns and gene sequences associated with clarithromycin and azithromycin resistance in Mycobacterium abscessus complex isolates and evaluation of the accumulation of intrinsic macrolide resistance.
|
Introduction. Mycobacterium abscessus complex (MABC) is an infectious agent associated with macrolide resistance and treatment failure.Hypothesis/Gap Statement. Despite drug-susceptibility testing for MABC isolates including clarithromycin (CAM), long-term treatment with azithromycin (AZM) for MABC disease is recommended.Aim. We compared phenotypic and genotypic resistance to AZM and CAM in clinical isolates and evaluated the accumulation of intrinsic macrolide resistance (AIM) and morphological changes by macrolides exposure.Methodology. Forty-nine isolates were characterized regarding erm(41) sequevars. Sequencing data were compared to the nucleotide sequence of rrl and whiB7. The AIM MIC was performed in three reference strains and 15 isolates were randomized [each set of five isolates with M. abscessus subsp. abscessus (MAA) T28, MAA C28 and subsp. massiliense (MAM)].Results. The 49 isolates were distributed as 24 MAA T28, 5 MAA C28 and 20 MAM. The MIC50 values to CAM at day 3 in MAA T28, C28 and MAM were 1, 0.12 and 0.12 µg ml[-1], while those at day 14 were 32, 0.5 and 0.12 µg ml[-1], respectively. The AZM-MIC50 values at day 3 of the above isolates were 4, 0.25 and 0.5 µg ml[-1], while those at day 14 were >64, 0.5 and 0.5 µg ml[-1], respectively. Neither mutations in rrl of MAA T28 with acquired resistance nor deletions in whiB7 of MAA T28 without inducible resistance were observed . For AIM MIC, MAA T28 showed that the time-to-detection of AZM resistance was significantly faster over that of CAM (P<0.05). Morphological changes were not determined in all isolates.Conclusion. Our findings did not support the suggestion for the preferential use of AZM for, at least, MAA T28 disease due to the high-level MIC value and the increased AIM. The long duration of AZM-based treatment eventually may favour the emergence of isolates with a high-level of intrinsic resistance.
|
2021 Mar
|
Journal of medical microbiology
|
No DOI
|
[
{
"LastName": "Yoshida",
"FirstName": "Shiomi",
"Affiliation": "Clinical Research Center, National Hospital Organization Kinki-chuo Chest Medical Center, Sakai-shi, Osaka, Japan."
},
{
"LastName": "Tsuyuguchi",
"FirstName": "Kazunari",
"Affiliation": "Clinical Research Center, National Hospital Organization Kinki-chuo Chest Medical Center, Sakai-shi, Osaka, Japan."
},
{
"LastName": "Kobayashi",
"FirstName": "Takehiko",
"Affiliation": "Internal Medicine, National Hospital Organization Kinki-chuo Chest Medical Center, Sakai-shi, Osaka, Japan."
},
{
"LastName": "Inoue",
"FirstName": "Yoshikazu",
"Affiliation": "Clinical Research Center, National Hospital Organization Kinki-chuo Chest Medical Center, Sakai-shi, Osaka, Japan."
},
{
"LastName": "Suzuki",
"FirstName": "Katsuhiro",
"Affiliation": "Internal Medicine, National Hospital Organization Kinki-chuo Chest Medical Center, Sakai-shi, Osaka, Japan."
}
] |
No
|
37919866
|
Validating a Xylose Regulator to Increase Polyhydroxybutyrate Production for Utilizing Mixed Sugars from Lignocellulosic Biomass Using Escherichia coli.
|
Polyhydroxybutyrate (PHB) production from lignocellulosic biomass is economically beneficial. Because lignocellulosic biomass is a mixture rich in glucose and xylose, Escherichia coli, which prefers glucose, needs to overcome glucose repression for efficient biosugar use. To avoid glucose repression, here, we overexpressed a xylose regulator (xylR) in an E. coli strain expressing bktB, phaB, and phaC from Cupriavidus necator and evaluated the effect of xylR on PHB production. XylR overexpression increased xylose consumption from 0% to 46.53% and produced 4.45-fold more PHB than the control strain without xylR in a 1% sugar mixture of glucose and xylose (1:1). When the xylR-overexpressed strain was applied to sugars from lignocellulosic biomass, cell growth and PHB production of the strain showed a 4.7-fold increase from the control strain, yielding 2.58 ± 0.02 g/l PHB and 4.43 ± 0.28 g/l dry cell weight in a 1% hydrolysate mixture. XylR overexpression increased the expression of xylose operon genes by up to 1.7-fold. Moreover, the effect of xylR was substantially different in various E. coli strains. Overall, the results showed the effect of xylR overexpression on PHB production in a non-native PHB producer and the possible application of xylR for xylose utilization in E. coli.
|
2024 Mar 28
|
Journal of microbiology and biotechnology
|
No DOI
|
[
{
"LastName": "Oh",
"FirstName": "Suk-Jin",
"Affiliation": "Department of Biological Engineering, College of Engineering, Konkuk University, Seoul 05029, Republic of Korea."
},
{
"LastName": "Lee",
"FirstName": "Hong-Ju",
"Affiliation": "Department of Biological Engineering, College of Engineering, Konkuk University, Seoul 05029, Republic of Korea."
},
{
"LastName": "Hwang",
"FirstName": "Jeong Hyeon",
"Affiliation": "Department of Biological Engineering, College of Engineering, Konkuk University, Seoul 05029, Republic of Korea."
},
{
"LastName": "Kim",
"FirstName": "Hyun Jin",
"Affiliation": "Department of Biological Engineering, College of Engineering, Konkuk University, Seoul 05029, Republic of Korea."
},
{
"LastName": "Shin",
"FirstName": "Nara",
"Affiliation": "Department of Biological Engineering, College of Engineering, Konkuk University, Seoul 05029, Republic of Korea."
},
{
"LastName": "Lee",
"FirstName": "Sang-Ho",
"Affiliation": "Department of Pharmacy, College of Pharmacy, Jeju National University, Jeju-si 63243, Republic of Korea."
},
{
"LastName": "Seo",
"FirstName": "Seung-Oh",
"Affiliation": "Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea."
},
{
"LastName": "Bhatia",
"FirstName": "Shashi Kant",
"Affiliation": "Department of Biological Engineering, College of Engineering, Konkuk University, Seoul 05029, Republic of Korea."
},
{
"LastName": "Yang",
"FirstName": "Yung-Hun",
"Affiliation": "Department of Biological Engineering, College of Engineering, Konkuk University, Seoul 05029, Republic of Korea."
}
] |
No
|
21770839
|
Inhibitory effects of three oleanolic acid glycosides from Achyranthes japonica on the complement classical pathway.
|
The present study evaluated the anticomplement effects of isolated compounds from Achyranthes japonica in the classical pathway of the complement system. Using column chromatography, three compounds: achyranthoside C dimethyl ester, achyranthoside C butyl dimethyl ester, and achyranthoside E dimethyl ester were isolated and evaluated for in vitro anticomplement activity. Achyranthoside C dimethyl ester showed the most potent inhibitory activity against the complement system, with 50% inhibitory concentrations (IC(50)) values of 26.2 μg/mL. This is the first report of anticomplement activity of isolated compounds from A. japonica.
|
2012 Apr
|
Immunopharmacology and immunotoxicology
|
No DOI
|
[
{
"LastName": "Jung",
"FirstName": "Seil",
"Affiliation": "Department of Urology, College of Medicine, Dong-A University, Busan, South Korea."
},
{
"LastName": "Lee",
"FirstName": "Jai-Heon",
"Affiliation": ""
},
{
"LastName": "Lee",
"FirstName": "Young-Choon",
"Affiliation": ""
},
{
"LastName": "Moon",
"FirstName": "Hyung-In",
"Affiliation": ""
}
] |
Yes
|
34703521
|
Progress in Catalytic Pyrolysis of Oil Shale.
|
This paper briefly describes the research status of oil shale pyrolysis technology and the main factors affecting oil shale pyrolysis, with emphasis on four kinds of commonly used catalysts: The effects of natural minerals, metal compounds, molecular sixes, and supported catalysts on the pyrolysis of oil shale were discussed. The changes of the pyrolysis mechanism and product composition of oil shale with the addition of different catalysts were discussed. Finally, the development direction of preparation of new catalysts was discussed, in order to provide a prospect for the development and utilization of unconventional and strategic alternative energy resources around the world.
|
2021
|
Scanning
|
No DOI
|
[
{
"LastName": "Li",
"FirstName": "Donghao",
"Affiliation": "College of Petroleum Engineering, Liaoning Petrochemical University, Fushun 113301, China."
},
{
"LastName": "Pan",
"FirstName": "Haodan",
"Affiliation": "College of Petroleum Engineering, Liaoning Petrochemical University, Fushun 113301, China."
},
{
"LastName": "Di",
"FirstName": "Xiaojing",
"Affiliation": "College of Petroleum Engineering, Liaoning Petrochemical University, Fushun 113301, China."
},
{
"LastName": "Liu",
"FirstName": "Xiaoyang",
"Affiliation": "Thermal Power Plant of PetroChina Fushun Petrochemical Company, Funshun 113301, China."
},
{
"LastName": "Hu",
"FirstName": "Hongxiang",
"Affiliation": "CAS Key Laboratory of Nuclear Materials and Safety Assessment, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China."
}
] |
No
|
35360446
|
COVID-Net CT-2: Enhanced Deep Neural Networks for Detection of COVID-19 From Chest CT Images Through Bigger, More Diverse Learning.
|
The COVID-19 pandemic continues to rage on, with multiple waves causing substantial harm to health and economies around the world. Motivated by the use of computed tomography (CT) imaging at clinical institutes around the world as an effective complementary screening method to RT-PCR testing, we introduced COVID-Net CT, a deep neural network tailored for detection of COVID-19 cases from chest CT images, along with a large curated benchmark dataset comprising 1,489 patient cases as part of the open-source COVID-Net initiative. However, one potential limiting factor is restricted data quantity and diversity given the single nation patient cohort used in the study. To address this limitation, in this study we introduce enhanced deep neural networks for COVID-19 detection from chest CT images which are trained using a large, diverse, multinational patient cohort. We accomplish this through the introduction of two new CT benchmark datasets, the largest of which comprises a multinational cohort of 4,501 patients from at least 16 countries. To the best of our knowledge, this represents the largest, most diverse multinational cohort for COVID-19 CT images in open-access form. Additionally, we introduce a novel lightweight neural network architecture called COVID-Net CT S, which is significantly smaller and faster than the previously introduced COVID-Net CT architecture. We leverage explainability to investigate the decision-making behavior of the trained models and ensure that decisions are based on relevant indicators, with the results for select cases reviewed and reported on by two board-certified radiologists with over 10 and 30 years of experience, respectively. The best-performing deep neural network in this study achieved accuracy, COVID-19 sensitivity, positive predictive value, specificity, and negative predictive value of 99.0%/99.1%/98.0%/99.4%/99.7%, respectively. Moreover, explainability-driven performance validation shows consistency with radiologist interpretation by leveraging correct, clinically relevant critical factors. The results are promising and suggest the strong potential of deep neural networks as an effective tool for computer-aided COVID-19 assessment. While not a production-ready solution, we hope the open-source, open-access release of COVID-Net CT-2 and the associated benchmark datasets will continue to enable researchers, clinicians, and citizen data scientists alike to build upon them.
|
2021
|
Frontiers in medicine
|
No DOI
|
[
{
"LastName": "Gunraj",
"FirstName": "Hayden",
"Affiliation": "Vision and Image Processing Lab, University of Waterloo, Waterloo, ON, Canada."
},
{
"LastName": "Sabri",
"FirstName": "Ali",
"Affiliation": "Department of Radiology, McMaster University, Hamilton, ON, Canada."
},
{
"LastName": "Koff",
"FirstName": "David",
"Affiliation": "Department of Radiology, McMaster University, Hamilton, ON, Canada."
},
{
"LastName": "Wong",
"FirstName": "Alexander",
"Affiliation": "Vision and Image Processing Lab, University of Waterloo, Waterloo, ON, Canada."
}
] |
No
|
33655577
|
Treatment of murine partial thickness scald injuries with multipotent adult progenitor cells decreases inflammation and promotes angiogenesis leading to improved burn injury repair.
|
Stem cells have been shown to have potential as a new therapy for burns and promote wound healing through decreasing inflammation and increasing angiogenesis. Multipotent adult progenitor cells (MAPC® cells) are a subpopulation of bone marrow-derived stem cells with outstanding self-renewal and differentiation capacity. MAPC cells also secrete a wide range of cytokines which can affect cellular activities. This article aimed to examine the effects of MAPC cells treatment on burn injury repair using a mouse model of partial thickness burn injury. The immunomodulatory effect of MAPC cells was investigated in vitro using a simultaneous T-cell proliferation assay. Partial thickness burns were created on the dorsal surface of mice and MAPC cells were administered via intradermal injection to the wound margins 24 h post-burn injury. The burn tissues were analysed macroscopically to determine wound area and histologically assessed to determine wound width and rate of re-epithelialisation. Immunohistochemistry and ELISA were employed to assess cell proliferation, inflammation and angiogenesis and collagen deposition in the burn area. MAPC cells inhibit the proliferation of stimulated T cells in culture. Burns intradermally injected with MAPC cells showed a significant reduction in the macroscopic wound area, histologic wound width and had an increased rate of re-epithelialisation. Immunohistochemistry and ELISA analysis of burn tissues showed dampened inflammation evidenced by a reduction in neutrophilic infiltration and modulation of inflammatory cytokines. Angiogenesis within the burn area was also improved in MAPC cell treated mice. However, no significant effect of MAPC cell treatment was observed on extracellular matrix production. Treatment of burns with MAPC cells improved burn injury repair with reduced time to healing, decreased inflammation and increased angiogenesis. These findings demonstrate the promising effects of MAPC cells on burn injury repair and suggest MAPC cells as a candidate source for clinical cell therapies.
|
2021 May
|
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
|
No DOI
|
[
{
"LastName": "Ahangar",
"FirstName": "Parinaz",
"Affiliation": "Future Industries Institute, University of South Australia, Adelaide, South Australia, Australia."
},
{
"LastName": "Mills",
"FirstName": "Stuart J",
"Affiliation": "Future Industries Institute, University of South Australia, Adelaide, South Australia, Australia."
},
{
"LastName": "Smith",
"FirstName": "Louise E",
"Affiliation": "Future Industries Institute, University of South Australia, Adelaide, South Australia, Australia."
},
{
"LastName": "Strudwick",
"FirstName": "Xanthe L",
"Affiliation": "Future Industries Institute, University of South Australia, Adelaide, South Australia, Australia."
},
{
"LastName": "Ting",
"FirstName": "Anthony E",
"Affiliation": "Athersys, Inc., Cleveland, Ohio, USA."
},
{
"LastName": "Vaes",
"FirstName": "Bart",
"Affiliation": "ReGenesys BV, Bio-Incubator Leuven, Leuven, Heverlee, Belgium."
},
{
"LastName": "Cowin",
"FirstName": "Allison J",
"Affiliation": "Future Industries Institute, University of South Australia, Adelaide, South Australia, Australia."
}
] |
No
|
38303450
|
An improved Kalman filter algorithm for tightly GNSS/INS integrated navigation system.
|
The Kalman filter based on singular value decomposition (SVD) can sufficiently reduce the accumulation of rounding errors and is widely used in various applications with numerical calculations. However, in order to improve the filtering performance and adaptability in a tightly GNSS/INS (Global Navigation Satellite System and Inertial Navigation System) integrated navigation system, we propose an improved robust method to satisfy the requirements. To solve the issue of large fluctuations in GNSS signals faced by the conventional method that uses a fixed noise covariance, the proposed method constructs a correction variable through the innovation and the new matrix which is obtained by performing SVD on the original matrix, dynamically correcting the noise covariance and has better robustness. In addition, the derived SVD form of the information filter (IF) extends its application. The proposed method has higher positioning accuracy and can be better applied to tightly coupled GNSS/INS navigation simulations and physical experiments. The experimental results show that, compared with the traditional Kalman algorithm based on SVD, the proposed algorithm*s maximum error is reduced by 45.77%. Compared with the traditional IF algorithm, the root mean squared error of the proposed IF algorithm in the form of SVD is also reduced by 4.7%.
|
2024 Jan
|
Mathematical biosciences and engineering : MBE
|
No DOI
|
[
{
"LastName": "Yuan",
"FirstName": "Yuelin",
"Affiliation": "School of Electronic Science, National University of Defense Technology, Changsha 410005, China."
},
{
"LastName": "Li",
"FirstName": "Fei",
"Affiliation": "School of Transportation and Logistics, Dalian University of Technology, Dalian 116024, China."
},
{
"LastName": "Chen",
"FirstName": "Jialiang",
"Affiliation": "School of Transportation and Logistics, Dalian University of Technology, Dalian 116024, China."
},
{
"LastName": "Wang",
"FirstName": "Yu",
"Affiliation": "School of Traffic and Transportation Engineering, Dalian Jiaotong University, Dalian 116028, China."
},
{
"LastName": "Liu",
"FirstName": "Kai",
"Affiliation": "School of Transportation and Logistics, Dalian University of Technology, Dalian 116024, China."
}
] |
No
|
22179404
|
Blockade of NKG2D synergized with CTLA4-Ig in promoting long-term graft survival in murine models of cardiac transplantation.
|
Blockade of B7-CD28 interaction with CTLA4-Ig could prolong allograft survival in cardiac transplantation. NKG2D is an activating or coactivating receptor on NK cells, γδ T, and CD8 T cells and played an important role in transplant immunity. C57BL/6 (wild type and γδ or interleukin (IL)-17) mice were transplanted with allogeneic BALB/c hearts and treated with CTLA4-Ig alone or in combination with anti-NKG2D monoclonal antibodies. The survival of grafts was monitored daily by abdominal palpation until the complete cessation of cardiac contractility. We found that wild type recipient treated with anti-NKG2D monoclonal antibodies plus CTLA4-Ig showed significantly prolonged survival cardiac allograft (>90 days, P<0.001). These in vivo results in combined therapy group correlated with low expression of interferon-γ whereas increased expression of IL-4 and alternatively activated macrophage markers. Furthermore, with blockade of NKG2D, the number of IL-17-producing γδ T cells was significantly reduced, which was demonstrated as the main source of IL-17 production. And in our γδ and IL-17 murine cardiac transplantation models, we found that γδ or IL-17 deficiency could significantly prolong cardiac allograft survival. Blockade of NKG2D is effective in synergizing with CTLA4-Ig to promote long-term cardiac allograft survival in mice, and this effect is associated with decreased infiltration of IL-17-producing γδ T cells.
|
2012 Feb 27
|
Transplantation
|
No DOI
|
[
{
"LastName": "Li",
"FirstName": "Jun",
"Affiliation": "Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [email protected]"
},
{
"LastName": "Zhu",
"FirstName": "Hongfei",
"Affiliation": ""
},
{
"LastName": "Wang",
"FirstName": "Sihua",
"Affiliation": ""
},
{
"LastName": "Ye",
"FirstName": "Ping",
"Affiliation": ""
},
{
"LastName": "Liu",
"FirstName": "Chenggui",
"Affiliation": ""
},
{
"LastName": "Wu",
"FirstName": "Jie",
"Affiliation": ""
},
{
"LastName": "Xia",
"FirstName": "Jiahong",
"Affiliation": ""
}
] |
Yes
|
34824600
|
IoT-Based Smart Health Monitoring System for COVID-19 Patients.
|
During the ongoing COVID-19 pandemic, Internet of Things- (IoT-) based health monitoring systems are potentially immensely beneficial for COVID-19 patients. This study presents an IoT-based system that is a real-time health monitoring system utilizing the measured values of body temperature, pulse rate, and oxygen saturation of the patients, which are the most important measurements required for critical care. This system has a liquid crystal display (LCD) that shows the measured temperature, pulse rate, and oxygen saturation level and can be easily synchronized with a mobile application for instant access. The proposed IoT-based method uses an Arduino Uno-based system, and it was tested and verified for five human test subjects. The results obtained from the system were promising: the data acquired from the system are stored very quickly. The results obtained from the system were found to be accurate when compared to other commercially available devices. IoT-based tools may potentially be valuable during the COVID-19 pandemic for saving people's lives.
|
2021
|
Computational and mathematical methods in medicine
|
No DOI
|
[
{
"LastName": "Khan",
"FirstName": "Mohammad Monirujjaman",
"Affiliation": "Department of Electrical and Computer Engineering, North South University, Bashundhara, Dhaka 1229, Bangladesh."
},
{
"LastName": "Mehnaz",
"FirstName": "Safia",
"Affiliation": "Department of Electrical and Computer Engineering, North South University, Bashundhara, Dhaka 1229, Bangladesh."
},
{
"LastName": "Shaha",
"FirstName": "Antu",
"Affiliation": "Department of Electrical and Computer Engineering, North South University, Bashundhara, Dhaka 1229, Bangladesh."
},
{
"LastName": "Nayem",
"FirstName": "Mohammed",
"Affiliation": "Department of Electrical and Computer Engineering, North South University, Bashundhara, Dhaka 1229, Bangladesh."
},
{
"LastName": "Bourouis",
"FirstName": "Sami",
"Affiliation": "Department of Information Technology, College of Computers and Information Technology, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia."
}
] |
Yes
|
36761014
|
Kelawakaju gen. nov., a new Asian lineage of marpissine jumping spiders (Araneae, Salticidae, Marpissina).
|
The genus Kelawakaju Maddison & Ruiz, gen. nov., is described for a lineage of bark-dwelling Asian marpissine jumping spiders that represent a dispersal to Eurasia separate from that of the Marpissa-Mendoza lineage, according to the phylogeny recovered from analysis of four gene regions. All species of Kelawakaju are new to science except Kelawakajufrenata (Simon, 1901), comb. nov., which is transferred from Ocrisiona Simon, 1901. Kelawakajufrenata is known from Hong Kong, Guangdong, Guangxi, and likely Taiwan. The five new species are Kelawakajumulu Maddison & Ruiz, sp. nov. (type species of Kelawakaju, from Sarawak, Malaysia, ♂♀), K.intexta Maddison & Ruiz, sp. nov. (from Sarawak, ♂), K.leucomelas Maddison & Ng, sp. nov. (Singapore and Johor Bahru, ♂♀), K.sahyadri Vishnudas, Maddison, & Sudhikumar, sp. nov. (India, ♂♀), and K.singapura Maddison & Ng, sp. nov. (Singapore, ♂♀).
|
2022
|
ZooKeys
|
No DOI
|
[
{
"LastName": "Maddison",
"FirstName": "Wayne P",
"Affiliation": "Departments of Zoology and Botany and Beaty Biodiversity Museum, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia, V6T 1Z4, Canada University of British Columbia Vancouver Canada."
},
{
"LastName": "Ruiz",
"FirstName": "Gustavo R S",
"Affiliation": "Instituto de Ciências Biológicas, Universidade Federal do Pará, Rua Augusto Corrêa, 01, CEP 66075-110, Belém, PA, Brazil Universidade Federal do Para Belém Brazil."
},
{
"LastName": "Ng",
"FirstName": "Paul Y C",
"Affiliation": "205 River Valley Road, #16-53, Singapore 238274, Singapore Unaffiliated Singapore Singapore."
},
{
"LastName": "Vishnudas",
"FirstName": "Ettukandathil Haridas",
"Affiliation": "Centre for Animal Taxonomy and Ecology, Department of Zoology, Christ College, Irinjalakuda, Kerala, 680 125, India Christ College Irinjalakuda India."
},
{
"LastName": "Sudhikumar",
"FirstName": "Ambalaparambil V",
"Affiliation": "Centre for Animal Taxonomy and Ecology, Department of Zoology, Christ College, Irinjalakuda, Kerala, 680 125, India Christ College Irinjalakuda India."
}
] |
No
|
38803349
|
The genome sequence of the yellow-legged black legionnaire, Beris morrisii (Dale, 1841).
|
We present a genome assembly from an individual female Beris morrisii (the yellow-legged black legionnaire; Arthropoda; Insecta; Diptera; Stratiomyidae). The genome sequence is 613.3 megabases in span. Most of the assembly is scaffolded into 5 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 16.69 kilobases in length.
|
2023
|
Wellcome open research
|
No DOI
|
[
{
"LastName": "McCulloch",
"FirstName": "James",
"Affiliation": "Department of Biology, University of Oxford, Oxford, England, UK."
}
] |
No
|
36199789
|
Screening of the Key Genes for the Progression of Liver Cirrhosis to Hepatocellular Carcinoma Based on Bioinformatics.
|
Hepatocellular carcinoma (HCC), which is among the most globally prevalent cancers, is strongly associated with liver cirrhosis. Using a bioinformatics approach, we have identified and investigated the hub genes responsible for the progression of cirrhosis into HCC. We analyzed the Gene Expression Omnibus (GEO) microarray datasets, GSE25097 and GSE17549, to identify differentially expressed genes (DEGs) in these two conditions and also performed protein-protein interaction (PPI) network analysis. STRING database and Cytoscape software were used to analyze the modules and locate hub genes following which the connections between hub genes and the transition from cirrhosis to HCC, progression of HCC, and prognosis of HCC were investigated. We used the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis to detect the molecular mechanisms underlying the action of the primary hub genes. In all, 239 DEGs were obtained, with 94 of them showing evidence of upregulation and 145 showing evidence of downregulation in HCC tissues as compared to cirrhotic liver tissues. We identified six hub genes, namely, BUB1B, NUSAP1, TTK, HMMR, CCNA2, and KIF2C, which were upregulated and had a high diagnostic value for HCC. Besides, these six hub genes were positively related to immune cell infiltration. Since these genes may play a direct role in the progression of cirrhosis to HCC, they can be considered as potential novel molecular indicators for the onset and development of HCC.
|
2022
|
Journal of oncology
|
No DOI
|
[
{
"LastName": "Chen",
"FirstName": "Yuanbin",
"Affiliation": "Medical School of Nantong University, Jiangsu, Nantong 226000, China."
},
{
"LastName": "Qian",
"FirstName": "Hongyan",
"Affiliation": "Key Laboratory of Cancer Research Center Nantong, Affiliated Tumor Hospital of Nantong University, Jiangsu, Nantong 226361, China."
},
{
"LastName": "He",
"FirstName": "Xiao",
"Affiliation": "Medical School of Nantong University, Jiangsu, Nantong 226000, China."
},
{
"LastName": "Zhang",
"FirstName": "Jing",
"Affiliation": "Medical School of Nantong University, Jiangsu, Nantong 226000, China."
},
{
"LastName": "Xue",
"FirstName": "Song",
"Affiliation": "Medical School of Nantong University, Jiangsu, Nantong 226000, China."
},
{
"LastName": "Wu",
"FirstName": "Yumeng",
"Affiliation": "Key Laboratory of Cancer Research Center Nantong, Affiliated Tumor Hospital of Nantong University, Jiangsu, Nantong 226361, China."
},
{
"LastName": "Chen",
"FirstName": "Jian",
"Affiliation": "The Immunology Laboratory, Affiliated Tumor Hospital of Nantong University, Jiangsu, Nantong 226361, China."
},
{
"LastName": "Wu",
"FirstName": "Xuming",
"Affiliation": "Nantong Fourth People's Hospital, Jiangsu Nantong 226001, China."
},
{
"LastName": "Zhang",
"FirstName": "Suqing",
"Affiliation": "Department of Hepatobiliary and Pancreatic Surgery, Affiliated Tumor Hospital of Nantong University, Jiangsu, Nantong 226361, China."
}
] |
No
|
35993018
|
The RPL4P4 Pseudogene Is a Prognostic Biomarker and Is Associated with Immune Infiltration in Glioma.
|
Research over the past decade has suggested important roles for pseudogenes in gliomas. Our previous study found that the RPL4P4 pseudogene is highly expressed in gliomas. However, its biological function in gliomas remains unclear. In this study, we analyzed clinical data on patients with glioma obtained from The Cancer Genome Atlas (TCGA), the Chinese Glioma Genome Atlas (CGGA), the Genotype-Tissue Expression (GTEx), and the GEPIA2 databases. We used the R language for the main analysis. Correlations among RPL4P4 expression, pathological characteristics, clinical outcome, and biological function were evaluated. In addition, the correlations of RPL4P4 expression with immune cell infiltration and glioma progression were analyzed. Finally, wound healing, Transwell, and CCK-8 assays were performed to analyze the function of RPL4P4 in glioma cells. We found that RPL4P4 is highly expressed in glioma tissues and is associated with poor prognosis, IDH1 wild type, codeletion of 1p19q, and age. Multivariate analysis and the nomogram model showed that high RPL4P4 expression was an independent risk factor for glioma prognosis and had better prognostic prediction power. Moreover, high RPL4P4 expression correlated with immune cell infiltration, which showed a significant positive association with M2-type macrophages. Finally, RPL4P4 knockdown in glioma cell lines caused decreased glioma cell proliferation, invasion, and migration capacity. Our data suggest that RPL4P4 can function as an independent prognostic predictor of glioma. It also shows that RPL4P4 expression correlates with immune cell infiltration and that targeting RPL4P4 may be a new strategy for the treatment of glioma patients.
|
2022
|
Oxidative medicine and cellular longevity
|
No DOI
|
[
{
"LastName": "Wang",
"FirstName": "Zengliang",
"Affiliation": "Department of Neurosurgery, Xinjiang Bazhou People's Hospital, Xinjiang, China."
},
{
"LastName": "Aili",
"FirstName": "Yirizhati",
"Affiliation": "Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China."
},
{
"LastName": "Wang",
"FirstName": "Yongxin",
"Affiliation": "Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China."
},
{
"LastName": "Maimaitiming",
"FirstName": "Nuersimanguli",
"Affiliation": "Department of Oncology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China."
},
{
"LastName": "Qin",
"FirstName": "Hu",
"Affiliation": "Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China."
},
{
"LastName": "Ji",
"FirstName": "Wenyu",
"Affiliation": "Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China."
},
{
"LastName": "Fan",
"FirstName": "Guofeng",
"Affiliation": "Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China."
},
{
"LastName": "Li",
"FirstName": "Bo",
"Affiliation": "Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, China."
}
] |
Yes
|
39011194
|
Navigating Portal Hypertension and Splenomegaly: A Clinical Encounter With an Unusual Variant of Cruveilhier-Baumgarten Syndrome.
|
Cruveilhier-Baumgarten syndrome presents a rare manifestation of portal hypertension characterized by a portosystemic shunt through a dilated paraumbilical vein, typically accompanied by classical signs such as caput medusae and a venous hum. We report a compelling case of a 41-year-old male presenting with portal hypertension, exhibiting clinical and radiological features of Cruveilhier-Baumgarten syndrome but notably lacking the characteristic venous hum. Clinical examination revealed moderate splenomegaly with prominent dilated veins and venous thrill but no caput medusae. Laboratory investigations indicated thrombocytopenia and esophageal varices on upper GI endoscopy. Imaging studies confirmed portal hypertension with findings consistent with Cruveilhier-Baumgarten syndrome, including a dilated paraumbilical vein and splenic artery aneurysms, along with the unexpected absence of a venous hum. Despite the classical radiological features, our patient did not present with hematemesis, possibly attributed to the presence of paraumbilical veins. This case highlights the diagnostic challenges and atypical presentations of Cruveilhier-Baumgarten syndrome, emphasizing the importance of comprehensive clinical evaluation and imaging modalities in its diagnosis and management. Management strategies primarily focus on addressing portal hypertension and underlying liver disease. This case underscores the need for further research to elucidate the varied clinical presentations and pathophysiology of Cruveilhier-Baumgarten syndrome variants, enhancing our understanding and management of this rare entity.
|
2024 Jun
|
Cureus
|
No DOI
|
[
{
"LastName": "Sharma",
"FirstName": "Abhishek",
"Affiliation": "General Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND."
},
{
"LastName": "Mehrotra",
"FirstName": "Pulkit",
"Affiliation": "Internal Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND."
},
{
"LastName": "Varadan",
"FirstName": "Sivaprakash",
"Affiliation": "General Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND."
},
{
"LastName": "Sudagar Singh",
"FirstName": "R B",
"Affiliation": "Internal Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND."
}
] |
No
|
35126641
|
An Improved Strategy for Task Scheduling in the Parallel Computational Alignment of Multiple Sequences.
|
Task scheduling in parallel multiple sequence alignment (MSA) through improved dynamic programming optimization speeds up alignment processing. The increased importance of multiple matching sequences also needs the utilization of parallel processor systems. This dynamic algorithm proposes improved task scheduling in case of parallel MSA. Specifically, the alignment of several tertiary structured proteins is computationally complex than simple word-based MSA. Parallel task processing is computationally more efficient for protein-structured based superposition. The basic condition for the application of dynamic programming is also fulfilled, because the task scheduling problem has multiple possible solutions or options. Search space reduction for speedy processing of this algorithm is carried out through greedy strategy. Performance in terms of better results is ensured through computationally expensive recursive and iterative greedy approaches. Any optimal scheduling schemes show better performance in heterogeneous resources using CPU or GPU.
|
2022
|
Computational and mathematical methods in medicine
|
No DOI
|
[
{
"LastName": "Ishaq",
"FirstName": "Muhammad",
"Affiliation": "Department of Computer Science and IT, Agriculture University Peshawar, Pakistan."
},
{
"LastName": "Khan",
"FirstName": "Asfandyar",
"Affiliation": "Department of Computer Science and IT, Agriculture University Peshawar, Pakistan."
},
{
"LastName": "Su'ud",
"FirstName": "Mazliham Mohd",
"Affiliation": "Faculty of Computing and Informatics Multimedia University Malaysia, Malaysia."
},
{
"LastName": "Alam",
"FirstName": "Muhammad Mansoor",
"Affiliation": "Faculty of Computing, Riphah International University, Islamabad, Pakistan."
},
{
"LastName": "Bangash",
"FirstName": "Javed Iqbal",
"Affiliation": "Department of Computer Science and IT, Agriculture University Peshawar, Pakistan."
},
{
"LastName": "Khan",
"FirstName": "Abdullah",
"Affiliation": "Department of Computer Science and IT, Agriculture University Peshawar, Pakistan."
}
] |
Yes
|
33263825
|
M1 Macrophage-Derived Exosomal MicroRNA-326 Suppresses Hepatocellular Carcinoma Cell Progression Via Mediating NF-κB Signaling Pathway.
|
Accumulating evidence has shown that microRNA (miR) derived from M1 macrophage-derived exosomes can regulate the progression of hepatocellular carcinoma (HCC). However, the effect of miR-326 derived from M1 macrophage-derived exosomes on HCC has not been reported. Therefore, the objective of the present study was to explore the mechanism of exosomal miR-326 from M1 macrophages in regulating HCC cell progression. RT-qPCR detected miR-326 expression in HCC cell lines. miR-326 expression in HCC was altered by transfection, and the effect of miR-326 on CD206 and NF-κB expression, cell proliferation, colony formation, migration, apoptosis and invasion was detected. Subsequently, exosomes were isolated from M1 macrophages. RT-qPCR identified miR-326 expression in M1 macrophage-derived exosomes. miR-326 expression in M1 macrophage-derived exosomes was changed by transfection. M1 macrophage-derived exosomes were co-cultured with HCC cells to figure out their effects on the biological progress of HCC cells. Finally, in vivo experiments were performed to verify the in vitro results. MiR-326 was decreased in HCC cells and enriched in M1 macrophage-derived exosomes. Up-regulating miR-326 would inhibit HCC cell proliferation, colony formation, migration, invasion, and CD206 and NF-κB expression and promoted apoptosis, and inhibited the growth of HCC tumors in vivo, while down-regulating miR-326 showed opposite effects. M1 macrophage-derived exosomes inhibited HCC cell proliferation, colony formation, migration, invasion, and CD206 and NF-κB expression and enhanced apoptosis, while overexpression of miR-326 enhanced the effect of M1 macrophage-derived exosomes on HCC cells. It is revealed that M1 macrophages-derived exosomal miR-326 suppresses proliferation, migration and invasion as well as advances apoptosis of HCC through down-regulating NF-κB expression.
|
2020 Dec 2
|
Nanoscale research letters
|
No DOI
|
[
{
"LastName": "Bai",
"FirstName": "Zhen-Zi",
"Affiliation": "Infectious Department, The Third Hospital of Jilin University, No. 126 Sendai Avenue, Changchun, 130033, Jilin, China."
},
{
"LastName": "Li",
"FirstName": "Hong-Yan",
"Affiliation": "Infectious Department, The Third Hospital of Jilin University, No. 126 Sendai Avenue, Changchun, 130033, Jilin, China."
},
{
"LastName": "Li",
"FirstName": "Cheng-Hua",
"Affiliation": "Infectious Department, The Third Hospital of Jilin University, No. 126 Sendai Avenue, Changchun, 130033, Jilin, China."
},
{
"LastName": "Sheng",
"FirstName": "Chuan-Lun",
"Affiliation": "Infectious Department, The Third Hospital of Jilin University, No. 126 Sendai Avenue, Changchun, 130033, Jilin, China."
},
{
"LastName": "Zhao",
"FirstName": "Xiao-Nan",
"Affiliation": "Infectious Department, The Third Hospital of Jilin University, No. 126 Sendai Avenue, Changchun, 130033, Jilin, China. [email protected]."
}
] |
Yes
|
22242035
|
More than just tumor destruction: immunomodulation by thermal ablation of cancer.
|
Over the past decades, thermoablative techniques for the therapy of localized tumors have gained importance in the treatment of patients not eligible for surgical resection. Anecdotal reports have described spontaneous distant tumor regression after thermal ablation, indicating a possible involvement of the immune system, hence an induction of antitumor immunity after thermoinduced therapy. In recent years, a growing body of evidence for modulation of both adaptive and innate immunity, as well as for the induction of danger signals through thermoablation, has emerged. Induced immune responses, however, are mostly weak and not sufficient for the complete eradication of established tumors or durable prevention of disease progression, and combination therapies with immunomodulating drugs are being evaluated with promising results. This article aims to summarize published findings on immune modulation through radiofrequency ablation, cryoablation, microwave ablation therapy, high-intensity focused ultrasound, and laser-induced thermotherapy.
|
2011
|
Clinical & developmental immunology
|
No DOI
|
[
{
"LastName": "Haen",
"FirstName": "Sebastian P",
"Affiliation": "Abteilung II fuer Onkologie, Haematologie, Immunologie, Rheumatologie, und Pulmologie, Medizinische Universitaetsklinik, Otfried Mueller Straße 10, 72076 Tuebingen, Germany. [email protected]"
},
{
"LastName": "Pereira",
"FirstName": "Philippe L",
"Affiliation": ""
},
{
"LastName": "Salih",
"FirstName": "Helmut R",
"Affiliation": ""
},
{
"LastName": "Rammensee",
"FirstName": "Hans-Georg",
"Affiliation": ""
},
{
"LastName": "Gouttefangeas",
"FirstName": "Cécile",
"Affiliation": ""
}
] |
No
|
24485343
|
Accelerated bilateral cataract formation as a first manifestation of diabetes mellitus.
|
There is a proved relationship between diabetes mellitus and the cataract formation. The incidence of this is usually related to the duration of diabetes. In this manuscript we report a 15 years old female presented to the emergency room with a 4 hour history of rapid bilateral diminished vision, initially diagnosed with idiopathic cataracts, but after more laboratory evaluations revealed new-onset type 1 diabetes mellitus without ketosis.
|
2013
|
Prague medical report
|
No DOI
|
[
{
"LastName": "Manaviat",
"FirstName": "M R",
"Affiliation": "Department of Ophthalmology, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran;"
},
{
"LastName": "Oveisi",
"FirstName": "N",
"Affiliation": "Department of Ophthalmology, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran;"
},
{
"LastName": "Zare-Bidoki",
"FirstName": "A",
"Affiliation": "Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran."
}
] |
No
|
35614491
|
The genetic technologies questionnaire: lay judgments about genetic technologies align with ethical theory, are coherent, and predict behaviour.
|
Policy regulations of ethically controversial genetic technologies should, on the one hand, be based on ethical principles. On the other hand, they should be socially acceptable to ensure implementation. In addition, they should align with ethical theory. Yet to date we lack a reliable and valid scale to measure the relevant ethical judgements in laypeople. We target this lacuna. We developed a scale based on ethical principles to elicit lay judgments: the Genetic Technologies Questionnaire (GTQ). In two pilot studies and a pre-registered main study, we validated the scale in a representative sample of the US population. The final version of the scale contains 20 items but remains highly reliable even when reduced to five. It also predicts behaviour; for example, ethical judgments as measured by the GTQ predicted hypothetical donations and grocery shopping. In addition, the GTQ may be of interest to policymakers and ethicists because it reveals coherent and ethically justified judgments in laypeople. For instance, the GTQ indicates that ethical judgments are sensitive to possible benefits and harms (in line with utilitarian ethics), but also to ethical principles such as the value of consent-autonomy. The GTQ can be recommended for research in both experimental psychology and applied ethics, as well as a tool for ethically and empirically informed policymaking.
|
2022 May 25
|
BMC medical ethics
|
No DOI
|
[
{
"LastName": "Küchenhoff",
"FirstName": "Svenja",
"Affiliation": "Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, Jülich, Germany."
},
{
"LastName": "Doerflinger",
"FirstName": "Johannes",
"Affiliation": "Department of Psychology, University of Konstanz, Konstanz, Germany."
},
{
"LastName": "Heinzelmann",
"FirstName": "Nora",
"Affiliation": "Institute of Philosophy, University of Erlangen-Nuremberg, Erlangen, Germany. [email protected]."
}
] |
No
|
34876921
|
CT Image Feature under Intelligent Algorithm in the Evaluation of Continuous Blood Purification in the Treatment and Nursing of Pulmonary Infection-Caused Severe Sepsis.
|
This study was to explore the CT image features based on intelligent algorithm to evaluate continuous blood purification in the treatment of severe sepsis caused by pulmonary infection and nursing. 50 patients in the hospital were selected as the research objects. Convolutional neural network algorithm was used to segment CT images of severe sepsis caused by pulmonary infection. They were randomly divided into 25 cases of experimental group and 25 cases of control group. The experimental group was given continuous blood purification treatment, combined with comprehensive nursing. The control group was given routine treatment and basic nursing. Fasting plasma glucose (FPG) and fasting insulin (FIN), interleukin-6 (IL-6), tumor necrosis factor (TNF-α), high-sensitivity c-reactive protein (hs-CRP) levels, CD3 [+], CD4 [+], CD4 [+/]CD8 [+] levels, ICU monitoring time, malnutrition inflammation score (MIS), and incidence of adverse events were compared between the two groups before and after treatment. There was no difference in FPG and FIN between the two groups before treatment. After treatment, the FPG and FIN of the experimental group were lower than those of the control group, and there was statistical significance (P < 0.05). There was no difference in IL-6, TNF-α, and hs-CRP between the two groups before treatment. After treatment, IL-6, TNF-α, and hs-CRP in the experimental group were lower than those in the control group. There was no difference in the percentage of CD3 [+], CD4 [+], and CD4 [+/]CD8 [+] between the two groups before treatment. After treatment, the CD3 [+], CD4 [+], and CD4 [+]/CD8 [+] in the experimental group were higher than those in the control group. The ICU monitoring time, MIS, and incidence of adverse events in the experimental group were lower than those in the control group (P > 0.05). Convolutional neural network algorithm can accurately identify and segment CT images of patients with severe sepsis, which has high clinical application value. Continuous blood purification therapy can effectively control blood glucose level, improve immune function, and reduce the content of inflammatory factors in patients with severe sepsis caused by pulmonary infection. Effective nursing measures can improve the therapeutic effect.
|
2021
|
Computational and mathematical methods in medicine
|
No DOI
|
[
{
"LastName": "Liu",
"FirstName": "Liping",
"Affiliation": "Department of Critical Care Medicine, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, 157011 Heilongjiang, China."
},
{
"LastName": "Liu",
"FirstName": "Yanyan",
"Affiliation": "Department of Critical Care Medicine, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, 157011 Heilongjiang, China."
},
{
"LastName": "Xing",
"FirstName": "Aimin",
"Affiliation": "Department of Critical Care Medicine, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, 157011 Heilongjiang, China."
},
{
"LastName": "Chen",
"FirstName": "Siyu",
"Affiliation": "Department of Critical Care Medicine, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, 157011 Heilongjiang, China."
},
{
"LastName": "Gu",
"FirstName": "Mingli",
"Affiliation": "Department of Critical Care Medicine, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, 157011 Heilongjiang, China."
}
] |
Yes
|
35815263
|
Cinobufacini Inhibits the Development of Pancreatic Cancer Cells through the TGFβ/Smads Pathway of Pancreatic Stellate Cells.
|
This study aimed to test cinobufacini therapeutic potential for pancreatic cancer, verify its potential molecular mechanism, and evaluate the cinobufacini impact on pancreatic cancer microenvironment. First, the effect of cinobufacini-treated pancreatic stellate cells (PSCs) supernatant on the value-added ability of pancreatic cancer (PCCs) was tested. The results show that cinobufacini can effectively reduce the ability of PSCs supernatant to promote the value-added PCCs. Further results show that cinobufacini can effectively reduce the concentration of TGFβ in the supernatant of PSCs. Subsequently, the impact of cinobufacini on the transcription and translation levels of key genes in the TGFβ/Smads pathway was examined. The results showed that the impact of cinobufacini on the transcription levels of Smad2, Smad3, and Smad7 was in a concentration-dependent manner, while the transcriptional activity of collagen I mRNA was decreased with the increase of cinobufacini concentration. The results of protein expression showed that cinobufacini could upregulate the expression of inhibitory protein Smad7, inhibit the phosphorylation level of p-Smad2/3, and then suppress the expression of type I collagen (collagen I). On the one hand, this study shows that cinobufacini can inhibit the promotion of PSCs on the proliferation of PCCs. On the other hand, cinobufacini can upregulate the expression of the inhibitory molecule, Smad7, through the TGFβ/Smads pathway and reduce the phosphorylation level of p-Smad2/3, thereby inhibiting the expression of collagen I and pancreatic fibrosis. cinobufacin can inhibit the proliferation of SW1900 cells by blocking the TGFβ/Smads pathway of pancreatic stellate cells. These results provide a clinical basis for the treatment of pancreatic cancer.
|
2022
|
Evidence-based complementary and alternative medicine : eCAM
|
No DOI
|
[
{
"LastName": "Li",
"FirstName": "Quan-Wang",
"Affiliation": "Department of Oncology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China."
},
{
"LastName": "Ma",
"FirstName": "Long-Fei",
"Affiliation": "Basic College of Peking Union Medical College, Beijing, China."
},
{
"LastName": "Liu",
"FirstName": "Chuan-Bo",
"Affiliation": "Department of Oncology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China."
},
{
"LastName": "Zhou",
"FirstName": "Jie",
"Affiliation": "The Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing, China."
},
{
"LastName": "Ma",
"FirstName": "Bin-Ya",
"Affiliation": "The Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing, China."
},
{
"LastName": "Zhuang",
"FirstName": "Yao-Xue",
"Affiliation": "The Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing, China."
},
{
"LastName": "Zhang",
"FirstName": "Ke-Rui",
"Affiliation": "Department of Oncology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China."
}
] |
Yes
|
33280258
|
Decreased drug resistance of bladder cancer using phytochemicals treatment.
|
The aim of the study is to investigate the ability of phytochemicals to overcome the multiple drug resistance (MDR) of bladder cancer. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate the cytotoxic sensitivity of T24-GCB cells, a GCB resistant cell line, to different phytochemicals, including capsaicin, quercetin, curcumin, and resveratrol, and their combination with gemcitabine. Western blot analysis was used to detect the expression of membranous ABCC2 and metabolic proteins, DCK, TK1, and TK2 in tumor cells. Animal models were used to confirm the treatment efficacy of phytochemicals in combination with gemcitabine to bladder cancer. The observed/expected ratio of cytotoxicity analysis revealed that capsaicin has synergistic effect with gemcitabine to T24-GCB cells in a dose-dependent pattern. Quercetin, curcumin, and resveratrol have additive effect with gemcitabine to T24-GCB cells. Capsaicin and quercetin alone and combination with gemcitabine decreased the expression of ABCC2 and DCK and TKs, in T24-GCB cells. On the contrary, resveratrol and curcumin alone and combination with gemcitabine increased the expression of ABCC2 but decreased cytoplasmic kinases simultaneously. In xenografted subcutaneous tumor model on nude mice, combination treatment of capsaicin and gemcitabine demonstrated the highest tumor suppression effect when compared to capsaicin or gemcitabine treatment alone. The MDR of bladder cancer is closely related to membranous ABCC2, cytoplasmic DCK, and TKs expression. Capsaicin owns the strongest synergistic cytotoxic effect of gemcitabine to T24-GCB cells. This combination regimen may provide as an adjunctive treatment for overcoming MDR in bladder cancer.
|
2021 Feb
|
The Kaohsiung journal of medical sciences
|
No DOI
|
[
{
"LastName": "Cho",
"FirstName": "Chun-Jung",
"Affiliation": "Graduate Institute of Pathology and Parasitology, National Defense Medical Center, Taipei, R.O.C."
},
{
"LastName": "Yu",
"FirstName": "Cheng-Ping",
"Affiliation": "Graduate Institute of Pathology and Parasitology, National Defense Medical Center, Taipei, R.O.C."
},
{
"LastName": "Wu",
"FirstName": "Chia-Lun",
"Affiliation": "Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, R.O.C."
},
{
"LastName": "Ho",
"FirstName": "Jar-Yi",
"Affiliation": "Graduate Institute of Pathology and Parasitology, National Defense Medical Center, Taipei, R.O.C."
},
{
"LastName": "Yang",
"FirstName": "Ching-Wei",
"Affiliation": "Department of Urology, Cheng-Hsin General Hospital, Taipei, R.O.C."
},
{
"LastName": "Yu",
"FirstName": "Dah-Shyong",
"Affiliation": "Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, R.O.C."
}
] |
No
|
35317283
|
SPI1-induced downregulation of FTO promotes GBM progression by regulating pri-miR-10a processing in an m6A-dependent manner.
|
As one of the most common post-transcriptional modifications of mRNAs and noncoding RNAs, N[6]-methyladenosine (m[6]A) modification regulates almost every aspect of RNA metabolism. Evidence indicates that dysregulation of m[6]A modification and associated proteins contributes to glioblastoma (GBM) progression. However, the function of fat mass and obesity-associated protein (FTO), an m[6]A demethylase, has not been systematically and comprehensively explored in GBM. Here, we found that decreased FTO expression in clinical specimens correlated with higher glioma grades and poorer clinical outcomes. Functionally, FTO inhibited growth and invasion in GBM cells in vitro and in vivo. Mechanistically, FTO regulated the m[6]A modification of primary microRNA-10a (pri-miR-10a), which could be recognized by reader HNRNPA2B1, recruiting the microRNA microprocessor complex protein DGCR8 and mediating pri-miR-10a processing. Furthermore, the transcriptional activity of FTO was inhibited by the transcription factor SPI1, which could be specifically disrupted by the SPI1 inhibitor DB2313. Treatment with this inhibitor restored endogenous FTO expression and decreased GBM tumor burden, suggesting that FTO may serve as a novel prognostic indicator and therapeutic molecular target of GBM.
|
2022 Mar 8
|
Molecular therapy. Nucleic acids
|
No DOI
|
[
{
"LastName": "Zhang",
"FirstName": "Shouji",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Zhao",
"FirstName": "Shulin",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Qi",
"FirstName": "Yanhua",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Li",
"FirstName": "Boyan",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Wang",
"FirstName": "Huizhi",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Pan",
"FirstName": "Ziwen",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Xue",
"FirstName": "Hao",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Jin",
"FirstName": "Chuandi",
"Affiliation": "Institute for Medical Dataology of Shandong University, Jinan, People's Republic of China."
},
{
"LastName": "Qiu",
"FirstName": "Wei",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Chen",
"FirstName": "Zihang",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Guo",
"FirstName": "Qindong",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Fan",
"FirstName": "Yang",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Xu",
"FirstName": "Jianye",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Gao",
"FirstName": "Zijie",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Wang",
"FirstName": "Shaobo",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Guo",
"FirstName": "Xing",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Deng",
"FirstName": "Lin",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Ni",
"FirstName": "Shilei",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Xue",
"FirstName": "Fuzhong",
"Affiliation": "Institute for Medical Dataology of Shandong University, Jinan, People's Republic of China."
},
{
"LastName": "Wang",
"FirstName": "Jian",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Zhao",
"FirstName": "Rongrong",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Li",
"FirstName": "Gang",
"Affiliation": "Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, China."
}
] |
No
|
34459316
|
The effect of Cushing's syndrome on pregnancy complication rates: analysis of more than 9 million deliveries.
|
The purpose of this study to evaluate the risk of Cushing's syndrome (CS) and maternal and fetal complications using the American Nationwide Inpatient Sample database. This is a retrospective study using the Health Care Cost and Utilization Project-Nationwide Inpatient Sample database from 2004 to 2014. We compared pregnancies with CS versus non-CS regarding pregnancy, delivery, and neonatal outcomes using multivariate logistic regression. We identified 9,096,788 pregnancies during the study period. Cushing's syndrome complicated 135 pregnancies at a rate of 1-2 cases per 100,000 births. Cushing's syndrome subjects were more likely to be older, obese, have private insurance, chronic hypertension, and pre-gestational diabetes (p<.001). The maternal mortality rate was 0.7 and 0.007% in Cushing's syndrome and control groups, respectively, although due to small numbers of cases, this should be interpreted with caution. Preeclampsia was higher in CS compared to controls after controlling for confounding variables, aOR 2.20. Operative vaginal delivery and blood transfusion rates were higher in CS patients than controls after controlling for confounding factors, aOR 6.49 and 3.09, respectively. The rates of preterm delivery (8.9 versus 7.2%) and gestational diabetes (8.1 versus 5.8%) were not statistically different between CS and control groups. Cushing's syndrome patients begin pregnancies often with maladies making them more at risk for complications including, preeclampsia, blood transfusion, and operative vaginal delivery. These patients might benefit from prevention methods for preeclampsia, and increased surveillance to decrease maternal morbidity and mortality. However, the nature of the database and its limitations, including the lack of information about CS activity and treatments received by patients, warrant careful interpretation of these results.
|
2022 Dec
|
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|
No DOI
|
[
{
"LastName": "Baghlaf",
"FirstName": "Haitham A",
"Affiliation": "Obstetrics & Gynecology Department, Division of Maternal-Fetal Medicine, University of Toronto, Toronto, Ontario, Canada."
},
{
"LastName": "Badeghiesh",
"FirstName": "Ahmad M",
"Affiliation": "Department of Obstetrics & Gynecology, McGill University, Montreal, Quebec, Canada."
},
{
"LastName": "Suarthana",
"FirstName": "Eva",
"Affiliation": "Department of Obstetrics & Gynecology, McGill University, Montreal, Quebec, Canada."
},
{
"LastName": "Dahan",
"FirstName": "Michael H",
"Affiliation": "Division of Reproductive Endocrinology and Infertility, MUHC Reproductive Center, McGill University, Montreal, Quebec, Canada."
}
] |
No
|
35003325
|
Network Pharmacology-Based Study on the Active Component and Mechanism of the Anti-Non-Invasive and Invasive Bladder Urothelial Carcinoma Effects of Zhuling Jisheng Decoction.
|
Zhuling Jisheng decoction is employed for the treatment of bladder urothelial cancer in clinical practice of traditional Chinese medicine. However, there are few studies on its precise mechanism. For the antibladder cancer action of Zhuling Jisheng decoction, a network pharmacological technique was used to design a component/target/pathway molecular regulatory network. The TCMSP dataset was used to identify the chemical makeup of Zhuling Jisheng decoction, which was then analyzed and assessed for oral bioavailability and pharmacological similarity. The chemical composition of Zhuling Jisheng decoction was identified through the TCMSP database, and it was evaluated and screened based on oral bioavailability and drug similarity. The GEO database was searched for genes associated with urothelial bladder carcinoma, and gene targets associated with bladder urothelial cancer resistance were chosen by comparison. The function and linked pathways of the target genes were examined and screened using annotation, visualization, and a comprehensive discovery database. The impact of Zhuling Jisheng decoction on urothelial bladder cancer was studied using Cytoscape software to create a component/target/pathway network. Finally, 69 and 55 target genes were discovered for noninvasive bladder urothelial cancer and invasive bladder urothelial cancer, respectively. In noninvasive urothelial cancer, 118 pathways were highly enriched, including the TNF signaling pathway and the IL-17 signaling route. 103 pathways were highly enriched in invasive urothelial cancer, including the p53 signaling route, bladder cancer route, and calcium signaling route. There were 18 and 15 drug targets associated with noninvasive and invasive bladder urothelial carcinoma prognoses. Many signaling pathways directly act on tumours, and indirect pathways inhibit the development of bladder urothelial carcinoma. This research establishes a scientific foundation for further research into the framework of action of Zhuling Jisheng decoction in the therapy of bladder urothelial cancer.
|
2021
|
Computational and mathematical methods in medicine
|
No DOI
|
[
{
"LastName": "Ma",
"FirstName": "Chenyu",
"Affiliation": "Third People's Hospital, Ningbo City, Zhejiang Province, No. 51-139, Zhouxi Highway, Cixi, China."
},
{
"LastName": "Wang",
"FirstName": "Jianlong",
"Affiliation": "Xi'an International Medical Center Hospital, China."
},
{
"LastName": "Zhao",
"FirstName": "Na",
"Affiliation": "Emergency Medicine Department, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, China."
},
{
"LastName": "Pan",
"FirstName": "Zhenya",
"Affiliation": "Emergency Medicine Department, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, China."
},
{
"LastName": "Lu",
"FirstName": "Yi",
"Affiliation": "Yiwu Fuyuan Private Hospital, China."
},
{
"LastName": "Cheng",
"FirstName": "Miao",
"Affiliation": "Department of Oncology, The Third People's Hospital of Hangzhou, Hangzhou, Zhejiang, China."
},
{
"LastName": "Deng",
"FirstName": "Min",
"Affiliation": "Emergency Medicine Department, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, China."
}
] |
Yes
|
35273786
|
Artificial Intelligence of Things- (AIoT-) Based Patient Activity Tracking System for Remote Patient Monitoring.
|
Telehealth and remote patient monitoring (RPM) have been critical components that have received substantial attention and gained hold since the pandemic's beginning. Telehealth and RPM allow easy access to patient data and help provide high-quality care to patients at a low cost. This article proposes an Intelligent Remote Patient Activity Tracking System system that can monitor patient activities and vitals during those activities based on the attached sensors. An Internet of Things- (IoT-) enabled health monitoring device is designed using machine learning models to track patient's activities such as running, sleeping, walking, and exercising, the vitals during those activities such as body temperature and heart rate, and the patient's breathing pattern during such activities. Machine learning models are used to identify different activities of the patient and analyze the patient's respiratory health during various activities. Currently, the machine learning models are used to detect cough and healthy breathing only. A web application is also designed to track the data uploaded by the proposed devices.
|
2022
|
Journal of healthcare engineering
|
No DOI
|
[
{
"LastName": "Malche",
"FirstName": "Timothy",
"Affiliation": "Manipal University Jaipur, Jaipur, India."
},
{
"LastName": "Tharewal",
"FirstName": "Sumegh",
"Affiliation": "School of Computer Science, Dr. Vishwanath Karad MIT World peace University, S. No.124, Paud Road, Kothrud, Pune 411038, Maharashtra, India."
},
{
"LastName": "Tiwari",
"FirstName": "Pradeep Kumar",
"Affiliation": "Manipal University Jaipur, Jaipur, India."
},
{
"LastName": "Jabarulla",
"FirstName": "Mohamed Yaseen",
"Affiliation": "School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea."
},
{
"LastName": "Alnuaim",
"FirstName": "Abeer Ali",
"Affiliation": "Department of Computer Science and Engineering, College of Applied Studies and Community Services, King Saud University, P.O. BOX 22459, Riyadh 11495, Saudi Arabia."
},
{
"LastName": "Hatamleh",
"FirstName": "Wesam Atef",
"Affiliation": "Department of Computer Science, College of Computer and Information Sciences, King Saud University, P.O. Box 51178, Riyadh 11543, Saudi Arabia."
},
{
"LastName": "Ullah",
"FirstName": "Mohammad Aman",
"Affiliation": "Department of Computer Science and Engineering, International Islamic University Chittagong, Chittagong, Bangladesh."
}
] |
Yes
|
24855467
|
5''-Benzyl-idene-5-chloro-1',1''-dimethyl-4'-phenyl-dispiro-[indoline-3,2'-pyrrolidine-3',3''-piperidine]-2,4''-dione.
|
The title compound, C30H28ClN3O2, features two spiro links, one connecting the piperidine and pyrrolidine rings, and the other connecting the pyrrolidine ring and indole residue. The configuration about the ethene bond is E. The piperidine ring adopts a half-chair conformation where the C atom connected to the spiro-C atom lies 0.713 (3) Å out of the plane of the remaining five atoms (r.m.s. deviation = 0.086 Å). The pyrrolidine ring has an envelope conformation with the flap atom being the methyl-ene C atom. Centrosymmetric eight-membered {⋯HNCO}2 amide synthons feature in the crystal packing. These are consolidated into a three-dimensional architecture by phen-yl-pyrrolidine C-H⋯N and chloro-benzene-pyrrolidine-bound phenyl C-H⋯π inter-actions.
|
2014 Jan 1
|
Acta crystallographica. Section E, Structure reports online
|
No DOI
|
[
{
"LastName": "Farag",
"FirstName": "I S Ahmed",
"Affiliation": "Solid State Department, Physics Division, National Research Centre, Dokki, Giza, Egypt."
},
{
"LastName": "Girgis",
"FirstName": "Adel S",
"Affiliation": "Pesticide Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt."
},
{
"LastName": "Ramadan",
"FirstName": "A A",
"Affiliation": "Physics Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt."
},
{
"LastName": "Moustafa",
"FirstName": "A M",
"Affiliation": "Solid State Department, Physics Division, National Research Centre, Dokki, Giza, Egypt."
},
{
"LastName": "Tiekink",
"FirstName": "Edward R T",
"Affiliation": "Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia."
}
] |
No
|
33340730
|
Intravascular ultrasonography provides more sensitive detection of subclavian vein stenosis than venography in patients presenting with Paget-Schroetter syndrome.
|
Spontaneous subclavian vein (SCV) thrombosis (Paget-Schroetter syndrome [PSS]) has been attributed to venous compression at the thoracic outlet and traditionally diagnosed using venography. Intravascular ultrasonography (IVUS) allows for a multidimensional view of vascular structures and might be more accurate in revealing venous compression. The goal of the present study was to compare venography and IVUS in patients presenting with PSS to assess the relative accuracy of each modality. Patients presenting for evaluation of PSS from 2013 to 2019 were evaluated for SCV compression using venography and IVUS. Venography and IVUS measurements of stenosis were performed of the index and contralateral limbs in both neutral and stress (arm overhead) positions. The IVUS data included the SCV diameters in the anteroposterior (AP) plane, craniocaudal (CC) plane, and cross-sectional area (CSA). Stenosis was reported as the percentage of reduction from a reference point (lateral margin of the first rib) for the venography and IVUS data. For the 35 subjects, the average age was 35 years, 57% were women, 20% had presented with a documented pulmonary embolus, and 70% had initially been treated with thrombolysis. Venography demonstrated SCV occlusion in 3 patients (16%) with the index limb in the neutral position and in 18 patients (54%) with the limb in the stress position. The average stenosis in the index limbs was 41.5% (venography), and the average IVUS stenosis was 41.9% (CC), 61.8% (AP), and 74.5% (CSA; P < .05). A subset analysis revealed that in 10 of 35 patients (28%) in whom venography had identified no significant stenosis (average, 10%), IVUS had identified significant stenosis (33.5% CC, 54.3% AP, 68.7% CSA; P < .05). IVUS proved more sensitive than venography in detecting significant stenosis leading to SCV thrombosis. A reduction in the CSA was the most sensitive measure of stenosis. IVUS identified significant stenosis in patients in whom venography failed to do so. The greatest utility of IVUS is in the evaluation of patients with PSS in whom venography shows no evident compression.
|
2021 Sep
|
Journal of vascular surgery. Venous and lymphatic disorders
|
No DOI
|
[
{
"LastName": "Ulloa",
"FirstName": "Jesus G",
"Affiliation": "Division of Vascular and Endovascular Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, Calif. Electronic address: [email protected]."
},
{
"LastName": "Gelabert",
"FirstName": "Hugh A",
"Affiliation": "Division of Vascular and Endovascular Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, Calif."
},
{
"LastName": "O'Connell",
"FirstName": "Jessica B",
"Affiliation": "Division of Vascular and Endovascular Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, Calif."
},
{
"LastName": "Patel",
"FirstName": "Rhusheet",
"Affiliation": "Division of Vascular and Endovascular Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, Calif."
},
{
"LastName": "Rigberg",
"FirstName": "David A",
"Affiliation": "Division of Vascular and Endovascular Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, Calif."
}
] |
No
|
36212987
|
Synthesis of Zinc Oxide (ZnO)-Titanium Dioxide (TiO(2))-Chitosan-Farnesol Nanocomposites and Assessment of Their Anticancer Potential in Human Leukemic MOLT-4 Cell Line.
|
Leukemia is the most prevalent cancer in children and one of the most common and deadly cancers that affect adults. Several metal oxide nanoparticles, biopolymers, and phytochemicals have been discovered to target cancer cells selectively while inflicting low to no damage to healthy cells. Among the existing nanoparticle synthesis methodologies, biologically synthesized nanoparticles using phytochemicals have emerged as a straightforward, economical, and environmentally sound strategy. The synergistic antitumor potential of ZnO-TiO2-chitosan-farnesol nanocomposites (NCs) against leukemia MOLT-4 cells was investigated in the current study. After synthesizing the NCs, characterization of the same was carried out using XRD, DLS, FESEM, TEM, PL, EDX, and FTIR spectroscopy. To analyze its anticancer activity, MOLT-4 cells were cultured and treated at diverse dosages of NCs. The cell viability upon treatment was examined by MTT assay. The morphological and nuclear modifications were observed by dual staining. ROS and MMP levels were observed by DCFH-DA staining and Rh-123 dye, respectively. Furthermore, the caspase 3, 8, and 9 levels were examined by performing ELISA. The XRD patterns exhibited a hexagonal structure of the NCs. In the DLS spectrum, the hydrodynamic diameter of the NCs was observed to be 126.2 nm. The electrostatic interface between the ZnO-TiO2-chitosan-farnesol NCs was confirmed by the FTIR spectra. A significant loss of cell viability in a dosage-dependent trend confirmed the cytotoxic effect of the NCs. An elevated ROS level and MMP depletion suggested apoptosis-associated cell death via the intrinsic pathway, which was confirmed by elevated expressions of caspase 3, 8, and 9 markers. Thus, the results showed that the synthesized NCs demonstrated a remarkable anticancer potential against leukemic cells and can be potentially valuable in cancer treatments. The findings from this study conclude that this is a new approach for modifying the physicochemical characteristics of ZnO-TiO2-chitosan-farnesol composites to increase their properties and synergistically exhibit anticancer properties in human leukemic cancer cells.
|
2022
|
Bioinorganic chemistry and applications
|
No DOI
|
[
{
"LastName": "Elderdery",
"FirstName": "Abozer Y",
"Affiliation": "Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia."
},
{
"LastName": "Alzahrani",
"FirstName": "Badr",
"Affiliation": "Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia."
},
{
"LastName": "Hamza",
"FirstName": "Siddiqa M A",
"Affiliation": "Faculty of Medicine, Department of Pathology, Umm Alqura University Algunfuda, Mecca, Saudi Arabia."
},
{
"LastName": "Mostafa-Hedeab",
"FirstName": "Gomaa",
"Affiliation": "Pharmacology & Therapeutic Department, Medical College, Jouf University, Sakaka, Saudi Arabia."
},
{
"LastName": "Mok",
"FirstName": "Pooi Ling",
"Affiliation": "Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia."
},
{
"LastName": "Subbiah",
"FirstName": "Suresh Kumar",
"Affiliation": "Centre for Materials Engineering and Regenerative Medicine, Bharath Institute of Higher Education and Research, Chennai, India."
}
] |
Yes
|
20299779
|
Transient visual loss triggered by scuba diving in a patient with a petrous epidermoid and combined thrombotic risk factors.
|
A 25-year-old woman who developed transient neurological abnormalities after scuba diving is reported. The subsequent day she experienced transient left-side monocular blindness. Arterial ocular occlusion in apparently healthy young women is unusual, and a search for the cause of this devastating vascular event is mandatory. Occlusion of the left branch retinal artery, total occlusion of the left internal carotid artery, and a petrous apex epidermoid were found, together with a shortened prothrombin time (INR: 0.73), a slightly elevated serum cholesterol level (6.1 mmol/l) and combined thrombophilia (elevated FVIIIC plus type 2 sticky platelet syndrome). This case underlines the complex mechanism of thromboembolic diseases, and the importance of the acquired trigger (in the present case scuba diving) in addition to the long-term anatomical and biochemical risk factors.
|
2007
|
Pathophysiology of haemostasis and thrombosis
|
No DOI
|
[
{
"LastName": "Fodor",
"FirstName": "Mariann",
"Affiliation": "Department of Ophthalmology, Medical and Health Sciences Center, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. [email protected]"
},
{
"LastName": "Facskó",
"FirstName": "Andrea",
"Affiliation": ""
},
{
"LastName": "Berényi",
"FirstName": "Ervin",
"Affiliation": ""
},
{
"LastName": "Sziklai",
"FirstName": "István",
"Affiliation": ""
},
{
"LastName": "Berta",
"FirstName": "András",
"Affiliation": ""
},
{
"LastName": "Pfliegler",
"FirstName": "György",
"Affiliation": ""
}
] |
No
|
26824034
|
Validation of Urine Test for Detection of Helicobacter pylori Infection in Indonesian Population.
|
We measured the accuracy of the urine test (RAPIRUN) for detection of Helicobacter pylori infection in Indonesia (Jakarta, Pontianak, and Jayapura) using histology confirmed by immunohistochemistry and/or culture as gold standards. We also used immunohistochemistry to identify CagA phenotype and analyzed H. pylori CagA diversity in Indonesia. The overall prevalence of H. pylori infection in 88 consecutive dyspeptic patients based on the urine test was 15.9% (14/88), 38.1% for patients in Jayapura that had higher prevalence of H. pylori infection than that in Jakarta (9.7%, P = 0.02) and Pontianak (8.3%, P = 0.006). Overall sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of RAPIRUN were 83.3%, 94.7%, 71.4%, 97.3%, and 93.2%, respectively. All of the H. pylori-positive patients were immunoreactive for anti-CagA antibody but not immunoreactive for East Asian specific anti-CagA antibody in all H. pylori-positive subjects. We confirmed the high accuracy of RAPIRUN in Indonesian population. In general, we found less virulent type of H. pylori in Indonesia, which partly explained the low incidence gastric cancer in Indonesia.
|
2015
|
BioMed research international
|
No DOI
|
[
{
"LastName": "Syam",
"FirstName": "Ari Fahrial",
"Affiliation": "Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta 10430, Indonesia."
},
{
"LastName": "Miftahussurur",
"FirstName": "Muhammad",
"Affiliation": "Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Japan; Gastroentero-Hepatology Division, Department of Internal Medicine, Airlangga University Faculty of Medicine, Surabaya 60131, Indonesia; Institute of Tropical Disease, Airlangga University, Surabaya 60115, Indonesia."
},
{
"LastName": "Uwan",
"FirstName": "Willy Brodus",
"Affiliation": "Department of Internal Medicine, Santo Antonius Hospital, Pontianak 78115, Indonesia."
},
{
"LastName": "Simanjuntak",
"FirstName": "David",
"Affiliation": "Department of Internal Medicine, Yowari Hospital, Jayapura 99352, Indonesia."
},
{
"LastName": "Uchida",
"FirstName": "Tomohisa",
"Affiliation": "Department of Molecular Pathology, Oita University Faculty of Medicine, Yufu 879-5593, Japan."
},
{
"LastName": "Yamaoka",
"FirstName": "Yoshio",
"Affiliation": "Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Japan; Department of Gastroenterology and Hepatology, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA."
}
] |
No
|
34760143
|
The Factors Affecting Orthodontic Pain with Periodontitis.
|
The occurrence of pain is often closely related to the psychological status, and the threshold for pain tolerance varies from patient to patient. In short, the factors affecting orthodontic pain are diverse and have individual differences. Tooth pain after the first force of intraoral malocclusion orthodontic treatment is one of the common complications of fixed orthodontic treatment, which often affects the outcome of treatment of patients with malocclusion and their subjective satisfaction with fixed orthodontic treatment. The purpose of the paper was to investigate the basic patterns and influencing factors of dental pain in fixed orthodontic patients within seven days after the initial wearing of straight arch aligners and the analysis of the effect of psychological intervention on dental pain using the visual simulation scoring method. According to the inclusion criteria of the experimental design, 89 patients who visited the Department of Orthodontics of Hospital for malocclusion were randomly divided into observation group and control group, and the observation group used chewing gum as psychological intervention, while the control group did not use any intervention. The effect of psychological intervention on periodontal pain was analyzed. The results of the paper were that all but 3 of the 89 patients had no pain, and all the patients had different degrees of dental pain at different points in time.
|
2021
|
Journal of healthcare engineering
|
No DOI
|
[
{
"LastName": "Peng",
"FirstName": "Yuzhi",
"Affiliation": "Department of Stomatology, First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550001, China."
},
{
"LastName": "Tang",
"FirstName": "Songjiang",
"Affiliation": "Department of Anesthesiology, First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550001, China."
}
] |
Yes
|
32600068
|
Morphological and functional assessment of the uterus: "one-stop shop imaging" using a compressed-sensing accelerated, free-breathing T1-VIBE sequence.
|
The combination of motion-insensitive, high-temporal, and spatial resolution imaging with evaluation of quantitative perfusion has the potential to increase the diagnostic capabilities of magnetic resonance imaging (MRI) in the female pelvis. To compare a free-breathing compressed-sensing VIBE (fbVIBE) with flexible temporal resolution (range = 4.6-13.8 s) with breath-hold VIBE (bhVIBE) and to evaluate the potential value of quantifying uterine perfusion. A total of 70 datasets from 60 patients (bhVIBE: n = 30; fbVIBE: n = 40) were evaluated by two radiologists. Only temporally resolved reconstruction (fbVIBE) was performed on 30 of the fbVIBE datasets. For a subset (n = 10) of the fbVIBE acquisitions, a time- and motion-resolved reconstruction (mrVIBE) was evaluated. Image quality (IQ), artifacts, diagnostic confidence (DC), and delineation of uterine structures (DoS) were graded on Likert scales (IQ/DC/DoS: 1 (non-diagnostic) to 5 (perfect); artifacts: 1 (no artifacts) to 5 (severe artifacts)). A Tofts model was applied for perfusion analysis. Ktrans was obtained in the myometrium (Mm), junctional zone (Jz), and cervix (Cx). The median IQ/DoS/DC scores of fbVIBE (4/5/5 κ >0.7-0.9) and bhVIBE (4/4/4; κ = 0.5-0.7; P > 0.05) were high, but Artifacts were graded low (fbVIBE/bhVIBE: 2/2; κ = 0.6/0.5; P > 0.05). Artifacts were only slightly improved by the additional motion-resolved reconstruction (fbVIBE/mrVIBE: 2/1.5; P = 0.08); fbVIBE was preferred in most cases (7/10). Significant differences of Ktrans values were found between Cx, Jz, and Mm (0.12/0.21/0.19; P < 0.05). The fbVIBE sequence allows functional and morphological assessment of the uterus at comparable IQ to bhVIBE.
|
2021 May
|
Acta radiologica (Stockholm, Sweden : 1987)
|
No DOI
|
[
{
"LastName": "Hausmann",
"FirstName": "Daniel",
"Affiliation": "Department of Radiology, Kantonsspital Baden, Baden, Switzerland."
},
{
"LastName": "Kreul",
"FirstName": "Diana",
"Affiliation": "Siemens Healthcare AG, Zürich, Switzerland."
},
{
"LastName": "Klarhöfer",
"FirstName": "Markus",
"Affiliation": "Siemens Healthcare AG, Zürich, Switzerland."
},
{
"LastName": "Nickel",
"FirstName": "Dominik",
"Affiliation": "MR Applications Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany."
},
{
"LastName": "Grimm",
"FirstName": "Robert",
"Affiliation": "MR Applications Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany."
},
{
"LastName": "Kiefer",
"FirstName": "Berthold",
"Affiliation": "MR Applications Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany."
},
{
"LastName": "Riffel",
"FirstName": "Philipp",
"Affiliation": "Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany."
},
{
"LastName": "Attenberger",
"FirstName": "Ulrike I",
"Affiliation": "Department of Radiology, University Hospital Bonn, Bonn, Germany."
},
{
"LastName": "Zöllner",
"FirstName": "Frank G",
"Affiliation": "Computer Assisted Clinical Medicine, Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany."
},
{
"LastName": "Kubik-Huch",
"FirstName": "Rahel A",
"Affiliation": "Department of Radiology, Kantonsspital Baden, Baden, Switzerland."
}
] |
No
|
33531817
|
Erratum: Chrysin Induced Cell Apoptosis and Inhibited Invasion Through Regulation of TET1 Expression in Gastric Cancer Cells [Corrigendum].
|
[This corrects the article DOI: 10.2147/OTT.S246031.].
|
2021
|
OncoTargets and therapy
|
No DOI
|
[] |
No
|
34765001
|
Proteomics Analysis of Serum Proteins in Gestational Diabetes.
|
The purpose of this study was to screen serum proteins for biomarkers of gestational diabetes mellitus (GDM) and to investigate its pathogenesis by analyzing the differences in serum proteomics between pregnant women with GDM and healthy pregnant women. Patients who were admitted to the First Affiliated Hospital of Fujian Medical University from June 2019 to January 2020 were included. According to the medical history and the results of the 75 g oral glucose tolerance test (OGTT), they were divided into the normal pregnant women group and GDM pregnant women group. The serum of two groups of patients was collected. High performance liquid chromatography-mass spectrometry was used to identify differentially expressed serum proteins between pregnant women with GDM and healthy pregnant women, and bioinformatics analysis was then performed on the identified proteins. A total of 1152 quantifiable proteins were detected; among them, 15 were upregulated in serum of GDM pregnant women, while 26 were downregulated. The subsequent parallel reaction monitoring (PRM) assay validated the expression levels of 12 out of 41 differentially expressed proteins. Moreover, bioinformatics analysis revealed that the differentially expressed proteins are involved in multiple biological processes and signaling pathways related to the lipid metabolism, glycan degradation, immune response, and platelet aggregation. This study identified 41 serum proteins with differential expression between pregnant women with GDM and healthy pregnant women, providing new candidate molecules for elucidating GDM pathogenesis and screening therapeutic targets.
|
2021
|
Evidence-based complementary and alternative medicine : eCAM
|
No DOI
|
[
{
"LastName": "Li",
"FirstName": "Jianhua",
"Affiliation": "Department of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China."
},
{
"LastName": "Lu",
"FirstName": "Lin",
"Affiliation": "Department of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China."
},
{
"LastName": "Xie",
"FirstName": "Xinping",
"Affiliation": "Department of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China."
},
{
"LastName": "Dai",
"FirstName": "Xiaofeng",
"Affiliation": "Department of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China."
},
{
"LastName": "Zheng",
"FirstName": "Shan",
"Affiliation": "Department of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China."
},
{
"LastName": "Chen",
"FirstName": "Lihong",
"Affiliation": "Department of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China."
}
] |
Yes
|
30565670
|
MicroRNA-1271 functions as a potential tumor suppressor in hepatitis B virus-associated hepatocellular carcinoma through the AMPK signaling pathway by binding to CCNA1.
|
Hepatocellular carcinoma (HCC) is mainly associated with hepatitis B virus (HBV) infection and characterized by metastasizing and infiltrating adjacent and distant tissues. Notably, microRNA-1271 (miR-1271) is a tumor suppressor in various cancers. Therefore, we evaluate the ability of miR-1271 to influence cell proliferation, migration, invasion, and apoptosis in HBV-associated HCC through the Adenosine monophosphate-activated protein kinase (AMPK) signaling pathway via targeting CCNA1. HBV-associated HCC and adjacent normal tissues were collected to identify the expression of miR-1271 and CCNA1. To verify the relationship between miR-1271 and CCNA1, we used bioinformatics prediction and the dual-luciferase reporter gene assay. The effects of miR-1271 on HBV-associated HCC cell behaviors were investigated by treatment of the miR-1271 mimic, the miR-1271 inhibitor, or small interfering RNA against CCNA1. The HBV-DNA quantitative assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromid assay, scratch test, transwell assay, and flow cytometry were used to detect HBV-DNA replication, cell proliferation, invasion, migration, and apoptosis. MiR-1271 showed a low expression, whereas CCNA1 showed a high expression in HBV-associated HCC tissues. We identified that miR-1271 targeted and negatively regulated CCNA1. Upregulated miR-1271 and downregulated CCNA1 inhibited the HBV-associated HCC cell HBV-DNA replication, proliferation, migration, and invasion, while accelerating apoptosis by activating the AMPK signaling pathway. MiR-1271 promotes the activation of the AMPK signaling pathway by binding to CCNA1, whereby miR-1271 suppresses HBV-associated HCC progression. This study points to a potential therapeutic approach of downregulation of miR-1271 in HBV-associated HCC treatment.
|
2019 Apr
|
Journal of cellular physiology
|
No DOI
|
[
{
"LastName": "Chen",
"FirstName": "Yang",
"Affiliation": "Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China."
},
{
"LastName": "Zhao",
"FirstName": "Zhen-Xian",
"Affiliation": "Department of Hepatobiliary Surgery, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."
},
{
"LastName": "Huang",
"FirstName": "Fei",
"Affiliation": "Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China."
},
{
"LastName": "Yuan",
"FirstName": "Xiao-Wei",
"Affiliation": "Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China."
},
{
"LastName": "Deng",
"FirstName": "Liang",
"Affiliation": "Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China."
},
{
"LastName": "Tang",
"FirstName": "Di",
"Affiliation": "Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China."
}
] |
Yes
|
36110573
|
Efficacy Analysis of Comprehensive Nursing in the Care of Ovarian Carcinoma Treated with Paclitaxel Combined with Nedaplatin.
|
To determine the effectiveness of comprehensive nursing in the care of ovarian carcinoma (OC) patients treated with paclitaxel (PTX) plus nedaplatin (NDP). The research population comprised 180 advanced OC patients who received treatment in the Shaanxi Cancer Hospital between November 2018 and November 2021. The enrolled cases were assigned to two groups based on different nursing plans: an observation group (OG) with 100 cases treated with comprehensive nursing and a control group (CG) with 80 cases intervened by conventional nursing. Intergroup comparisons were performed to identify statistical significance in terms of the following parameters: serum NGF, TK1, and CA15-3 levels; VAS, SAS, and SDS scores; nursing compliance; incidence of adverse reactions; and nursing satisfaction. Compared with CG, OG showed the following: (1) lower posttreatment NGF, TK1, and CA15-3 levels; (2) lower scores of SAS and SDS; (3) higher nursing compliance; and (4) lower incidence of adverse reactions and higher nursing satisfaction after nursing. Comprehensive nursing far outperformed conventional nursing in the care of advanced OC patients treated with PTX plus NDP, which is worth popularizing.
|
2022
|
Computational and mathematical methods in medicine
|
No DOI
|
[
{
"LastName": "Li",
"FirstName": "Yahui",
"Affiliation": "Department of Gynecology and Oncology, Shaanxi Cancer Hospital, Xi'an, 710061 Shaanxi, China."
},
{
"LastName": "Wu",
"FirstName": "Jing",
"Affiliation": "Department of General Surgery, Shaanxi Cancer Hospital, Xi'an, 710061 Shaanxi, China."
},
{
"LastName": "Zhu",
"FirstName": "Gehong",
"Affiliation": "Department of Gynecology and Oncology, Shaanxi Cancer Hospital, Xi'an, 710061 Shaanxi, China."
}
] |
Yes
|
18244648
|
Data hiding watermarking for halftone images.
|
In many printer and publishing applications, it is desirable to embed data in halftone images. We proposed some novel data hiding methods for halftone images. For the situation in which only the halftone image is available, we propose data hiding smart pair toggling (DHSPT) to hide data by forced complementary toggling at pseudo-random locations within a halftone image. The complementary pixels are chosen to minimize the chance of forming visually undesirable clusters. Our experimental results suggest that DHSPT can hide a large amount of hidden data while maintaining good visual quality. For the situation in which the original multitone image is available and the halftoning method is error diffusion, we propose the modified data hiding error diffusion (MDHED) that integrates the data hiding operation into the error diffusion process. In MDHED, the error due to the data hiding is diffused effectively to both past and future pixels. Our experimental results suggest that MDHED can give better visual quality than DHSPT. Both DHSPT and MDHED are computationally inexpensive.
|
2002
|
IEEE transactions on image processing : a publication of the IEEE Signal Processing Society
|
No DOI
|
[
{
"LastName": "Fu",
"FirstName": "Ming Sun",
"Affiliation": "Dept. of Electr. and Electron. Eng., Hong Kong Univ. of Sci. and Technol. [email protected]"
},
{
"LastName": "Au",
"FirstName": "Oscar C",
"Affiliation": ""
}
] |
No
|
35186230
|
Research on a Health Care Personnel Training Model Based on Multilayered Knowledge Mapping for the Integration of Nursing Courses and Examinations.
|
While nursing courses provide a convenient and quick way to learn, they can also be overloaded with resources that can cause learners to become cognitively disoriented or have difficulty choosing nursing course. This paper proposes to fully explore learners' interests in the case of sparse data by fusing knowledge graph technology and deep recommendation models and adopt knowledge graph to model nursing courses at the semantic level so as to correspond the set of nursing courses to the knowledge graph and solve the problem of lack of logical knowledge relationships. Due to the specificity of its positions, the nursing profession must accurately position the nursing professional curriculum standards in the process of determining the talent cultivation model based on the nursing professional positions and the admission requirements for nursing practice qualification. Through linear feature mining based on the knowledge graph, entities and relationships are used to intuitively display the interest paths of nursing professional learners and enhance the interpretability of recommendations.
|
2022
|
Journal of healthcare engineering
|
No DOI
|
[
{
"LastName": "Lv",
"FirstName": "Qingna",
"Affiliation": "Nursing Department, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, China."
},
{
"LastName": "Zhang",
"FirstName": "Yanyun",
"Affiliation": "College of Nursing, Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia Autonomous Region, China."
},
{
"LastName": "Li",
"FirstName": "Yanyan",
"Affiliation": "College of Nursing, Chongqing Medical and Pharmaceutical College, Shapingba, Chongqing 401331, China."
},
{
"LastName": "Yu",
"FirstName": "Yang",
"Affiliation": "Nursing Department, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, China."
}
] |
Yes
|
17656999
|
Two cases of rare presentation of basal cell and squamous cell carcinoma on the hand.
|
Two cases of rare presentation in the form of basal cell carcinoma for 2-3 years and squamous cell carcinoma for 8-9 years after prolonged sun exposure are being reported. Both responded to surgical excision and 5-FU application.
|
2002 Nov-Dec
|
Indian journal of dermatology, venereology and leprology
|
No DOI
|
[
{
"LastName": "Kumar",
"FirstName": "Neeta",
"Affiliation": "Department of Radiotherapy, Lady Hardinge Medical College and associated Smt. S. K. Hospital, New Delhi, India. [email protected]"
},
{
"LastName": "Saxena",
"FirstName": "Y K",
"Affiliation": ""
}
] |
No
|
19088430
|
Vasopressin regulates the phosphorylation state of AMP-activated protein kinase (AMPK) in MDCK-C7 cells.
|
AMP-activated protein kinase (AMPK) is a regulatory kinase coupling cellular metabolism with ion transport. Madin-Darby Canine Kidney-Clone 7 (MDCK-C7) cells possess characteristics of the renal principal cell type, express the cystic fibrosis transmembrane regulator and the epithelial Na(+) channel, and display NPPB and amiloride-sensitive transepithelial transport when stimulated with [Arg(8)]-vasopressin. [Arg(8)]-vasopressin binding to its receptor on the basolateral membrane of MDCK-C7 results in cAMP production, activation of cAMP-dependent protein kinase A (PKA), and increases in Cl(-) and Na(+) transport. Ussing-style electrophysiology showed that the PKA inhibitor, H89, blocked Cl(-) and Na(+) transport. Unexpectedly, [Arg(8)]-vasopressin stimulation resulted in the dephosphorylation of pAMPK(thr172). H89 did not prevent this, suggesting that the dephosphorylation is independent of PKA. 24 hour, but not 15 minute, incubation with the AMPK activator, AICAR, also blocked [Arg(8)]-vasopressin-stimulated currents. Contrary to previous studies, immunoblotting revealed that AICAR did not increase abundance of the active, phosphorylated form of AMPK (pAMPK(thr172)); although, AICAR treatment significantly blocked [Arg(8)]-vasopressin -stimulated cAMP production. [Arg(8)]-vasopressin still caused pAMPK(thr172) dephosphorylation in the presence of AICAR, suggesting that this effect is also independent of cAMP. In summary, these data suggest [Arg(8)]-vasopressin regulates AMPK phosphorylation and that AICAR inhibits ion transport independently of AMPK in MDCK-C7 cells.
|
2008
|
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
|
No DOI
|
[
{
"LastName": "Nofziger",
"FirstName": "Charity",
"Affiliation": "Department of Biology, Indiana University, Indianapolis, USA."
},
{
"LastName": "Kalsi",
"FirstName": "Kameljit",
"Affiliation": ""
},
{
"LastName": "West",
"FirstName": "T Aaron",
"Affiliation": ""
},
{
"LastName": "Baines",
"FirstName": "Deborah",
"Affiliation": ""
},
{
"LastName": "Blazer-Yost",
"FirstName": "Bonnie L",
"Affiliation": ""
}
] |
No
|
26345039
|
Mosquitocidal properties of Bacillus species isolated from mangroves of Vellar estuary, Southeast coast of India.
|
Samples collected from the mangroves of Vellar estuary yielded a mosquitocidal bacterium, whose secondary metabolites exhibited mosquito larvicidal and pupicidal activity. The bacterium was isolated using standard microbiological methods and identified using classical biochemical tests. The mosquitocidal bacterium was identified as Bacillus subtilis, Bacillus thuringiensis, Bacillus sphaericus and Bacillus cereus. Mosquitocidal metabolite(s) was separated from the culture supernatant of the bacterium and its efficacy was against the larval and pupal stages of two different species of mosquitoes and determined in terms of LC50 and LC90. Mosquito larvicidal activity in terms of LC50 against Anopheleus stephensi and Aedes aegypti was 4.374 and 7.406 μl/ml and its pupicidal activity was 4.928 and 9.865 μl/ml, respectively. The present study proved that the mosquitocidal properties of the Bacillus species isolated from mangroves of Vellar estuary was evaluated as target species of mosquito vectors. This is an ideal eco-friendly approach for the vector control programs.
|
2015 Sep
|
Journal of parasitic diseases : official organ of the Indian Society for Parasitology
|
No DOI
|
[
{
"LastName": "Balakrishnan",
"FirstName": "S",
"Affiliation": "Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, 608 502 Tamil Nadu INDIA."
},
{
"LastName": "Indira",
"FirstName": "K",
"Affiliation": "Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, 608 502 Tamil Nadu INDIA."
},
{
"LastName": "Srinivasan",
"FirstName": "M",
"Affiliation": "Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, 608 502 Tamil Nadu INDIA."
}
] |
Yes
|
31904151
|
miR-133a-3p/FOXP3 axis regulates cell proliferation and autophagy in gastric cancer.
|
Although many methods and new therapeutic drugs have been developed, the overall survival rate and long-term survival rate of patients with gastric cancer (GC) are still not satisfactory. In this study, we investigated the effects of microRNA miR-133a-3p and transcription factor FOXP3 on proliferation and autophagy of GC cells and their interactions. Our results showed that knockdown of FOXP3 increased the proliferation and autophagy of GC cells. The relationship between FOXP3 and autophagy has not been reported previously. In addition, FOXP3 could directly bind the promoter region of TP53 and inhibit its expression. miR-133a-3p increased the proliferation and autophagy via decreasing the protein level of FOXP3 by targeting its 3'-UTR. Our research provides new insights into the development of GC and provides new ideas and theoretical basis for the clinical treatment of GC and the development of new drug targets.
|
2020 Jun
|
Journal of cellular biochemistry
|
No DOI
|
[
{
"LastName": "Li",
"FirstName": "Jia-Peng",
"Affiliation": "College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China."
},
{
"LastName": "Zhang",
"FirstName": "Hui-Min",
"Affiliation": "College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China."
},
{
"LastName": "Liu",
"FirstName": "Mei-Jun",
"Affiliation": "College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China."
},
{
"LastName": "Xiang",
"FirstName": "Yuan",
"Affiliation": "College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China."
},
{
"LastName": "Li",
"FirstName": "Hui",
"Affiliation": "College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China."
},
{
"LastName": "Huang",
"FirstName": "Feng",
"Affiliation": "College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China."
},
{
"LastName": "Li",
"FirstName": "Han-Han",
"Affiliation": "College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China."
},
{
"LastName": "Dai",
"FirstName": "Zhou-Tong",
"Affiliation": "College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China."
},
{
"LastName": "Gu",
"FirstName": "Chao Jiang",
"Affiliation": "College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China."
},
{
"LastName": "Liao",
"FirstName": "Xing-Hua",
"Affiliation": "College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China."
},
{
"LastName": "Zhang",
"FirstName": "Tong-Cun",
"Affiliation": "College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China."
}
] |
No
|
37083077
|
TFAP2A promotes cervical cancer via a positive feedback pathway with PD‑L1.
|
Transcription factor AP‑2 alpha (TFAP2A) is a critical cell growth regulator that is overexpressed in various tumor tissues. However, its role in the development of cervical cancer remains unknown. In the present study, public databases were thus explored and a higher expression of TFAP2A was found in cervical cancer. A total of 131 clinical samples were collected and it was also identified that TFAP2A was highly expressed in cervical tumor tissues. TFAP2A was also found to be associated with a higher tumor stage, lymph node metastasis and a poor patient survival. In vitro experiments revealed that the knockdown of TFAP2A inhibited the proliferation and migration of cervical cancer cells and promoted apoptosis. Furthermore, it was observed that TFAP2A could bind the programmed death‑ligand 1 (PD‑L1) promoter region and PD‑L1 rescued TFAP2A expression. In vivo experiments also revealed that TFAP2A promoted tumor growth. Collectively, in the present study it was demonstrated that TFAP2A is a transcription factor of PD‑L1 and a prognostic factor with clinical value, identifying a positive feedback loop of TFAP2A/PD‑L1.
|
2023 Jun
|
Oncology reports
|
No DOI
|
[
{
"LastName": "Yang",
"FirstName": "Junyuan",
"Affiliation": "Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China."
},
{
"LastName": "Gao",
"FirstName": "Yang",
"Affiliation": "Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China."
},
{
"LastName": "Yao",
"FirstName": "Sinjie",
"Affiliation": "Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China."
},
{
"LastName": "Wan",
"FirstName": "Shimeng",
"Affiliation": "Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China."
},
{
"LastName": "Cai",
"FirstName": "Hongbing",
"Affiliation": "Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China."
}
] |
No
|
39014053
|
Delta waves as a sign of cortical plasticity after full-face transplantation.
|
This study focused on detecting the reflections of healing and change in cortex activation in full-face transplantation and lesions patients on EEG activity. Face transplant patients have facial lesions before transplantation and, to identify pre-face transplant patients' brain activity in the absence of pre-transplant recordings, we used data obtained from pre-transplant facial lesion patients. Ten healthy, four facial lesion and three full-face transplant patients participated in this study. EEG data recorded for four different sensory stimuli (brush from the right face, right hand, left face, and left-hand regions) were analyzed using wavelet packet transform method. EEG waves were analyzed for standard bands. Our findings indicate significant change in the 2-4 Hz frequency range which may be a result of ongoing or previous cortical reorganization for face lesion and transplant patients. Alterations of the delta wave seen in patients with facial lesion and face transplant can also be explained by the intense central plasticity. Our findings show that the delta band differences might be used as a marker in the evaluation of post-transplant cortical plasticity in the future.
|
2024 Jul 16
|
Scientific reports
|
No DOI
|
[
{
"LastName": "Süzen",
"FirstName": "Esra",
"Affiliation": "Faculty of Engineering, Department of Electrical and Electronics Engineering, Akdeniz University, Pınarbasi Blvd., Antalya, Turkey."
},
{
"LastName": "Şavklıyıldız",
"FirstName": "Ayhan",
"Affiliation": "Faculty of Engineering, Department of Electrical and Electronics Engineering, Akdeniz University, Pınarbasi Blvd., Antalya, Turkey."
},
{
"LastName": "Özkan",
"FirstName": "Ömer",
"Affiliation": "Faculty of Medicine, Department of Plastic and Reconstructive Surgery, Akdeniz University, Antalya, Turkey."
},
{
"LastName": "Çolak",
"FirstName": "Ömer Halil",
"Affiliation": "Faculty of Engineering, Department of Electrical and Electronics Engineering, Akdeniz University, Pınarbasi Blvd., Antalya, Turkey. [email protected]."
},
{
"LastName": "Apaydın Doğan",
"FirstName": "Ebru",
"Affiliation": "Faculty of Medicine, Department of Neurology, Akdeniz University, Antalya, Turkey."
},
{
"LastName": "Özkan",
"FirstName": "Özlenen",
"Affiliation": "Faculty of Medicine, Department of Plastic and Reconstructive Surgery, Akdeniz University, Antalya, Turkey."
},
{
"LastName": "Şimşek",
"FirstName": "Buket",
"Affiliation": "Faculty of Engineering, Department of Electrical and Electronics Engineering, Akdeniz University, Pınarbasi Blvd., Antalya, Turkey."
},
{
"LastName": "Uluşar",
"FirstName": "Ümit Deniz",
"Affiliation": "Faculty of Engineering, Department of Computer Engineering, Akdeniz University, Antalya, Turkey."
},
{
"LastName": "Carlak",
"FirstName": "Hamza Feza",
"Affiliation": "Faculty of Engineering, Department of Electrical and Electronics Engineering, Akdeniz University, Pınarbasi Blvd., Antalya, Turkey."
},
{
"LastName": "Polat",
"FirstName": "Övünç",
"Affiliation": "Faculty of Engineering, Department of Electrical and Electronics Engineering, Akdeniz University, Pınarbasi Blvd., Antalya, Turkey."
},
{
"LastName": "Uysal",
"FirstName": "Hilmi",
"Affiliation": "Faculty of Medicine, Department of Neurology, Akdeniz University, Antalya, Turkey."
}
] |
No
|
38017474
|
Efficacy of high-flow nasal cannula in patients with acute heart failure: a systematic review and meta-analysis.
|
Acute heart failure (AHF) is often associated with diffuse insufficiency and arterial hypoxemia, requiring respiratory support for rapid and effective correction. We aimed to compare the effects of high-flow nasal cannula(HFNC) with those of conventional oxygen therapy(COT) or non-invasive ventilation(NIV) on the prognosis of patients with AHF. We performed the search using PubMed, Embase, Web of Science, MEDLINE, the Cochrane Library, CNKI, Wanfang, and VIP databases from the inception to August 31, 2023 for relevant studies in English and Chinese. We included controlled studies comparing HFNC with COT or NIV in patients with AHF. Primary outcomes included the intubation rate, respiratory rate (RR), heart rate (HR), and oxygenation status. From the 1288 original papers identified, 16 studies met the inclusion criteria, and 1333 patients were included. Compared with COT, HFNC reduced the intubation rate (odds ratio [OR]: 0.29, 95% CI: 0.14-0.58, P = 0.0005), RR (standardized mean difference [SMD]: -0.73 95% CI: -0.99 - -0.47, P < 0.00001) and HR (SMD: -0.88, 95% CI: -1.07 - -0.69, P < 0.00001), and hospital stay (SMD: -0.94, 95% CI: -1.76 - -0.12, P = 0.03), and increase arterial oxygen partial pressure (PaO2), (SMD: 0.88, 95% CI: 0.70-1.06, P < 0.00001) and oxygen saturation (SpO2 [%], SMD: 0.70, 95% CI: 0.34-1.06, P = 0.0001). There were no significant differences in intubation rate, RR, HR, arterial blood gas parameters, and dyspnea scores between the HFNC and NIV groups. Compared with COT, HFNC effectively reduced the intubation rate and provided greater clinical benefits to patients with AHF. However, there was no significant difference in the clinical prognosis of patients with AHF between the HFNC and NIV groups. PROSPERO (identifier: CRD42022365611).
|
2023 Nov 28
|
BMC pulmonary medicine
|
No DOI
|
[
{
"LastName": "Yan",
"FirstName": "Liming",
"Affiliation": "Department of Pulmonary and Critical Care Medicine, Fourth Hospital of China Medical University, Shenyang, China."
},
{
"LastName": "Lu",
"FirstName": "Ye",
"Affiliation": "Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, China."
},
{
"LastName": "Deng",
"FirstName": "Mingming",
"Affiliation": "Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China."
},
{
"LastName": "Zhang",
"FirstName": "Qin",
"Affiliation": "Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China."
},
{
"LastName": "Bian",
"FirstName": "Yiding",
"Affiliation": "Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China."
},
{
"LastName": "Zhou",
"FirstName": "Xiaoming",
"Affiliation": "Respiratory Department, Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. [email protected]."
},
{
"LastName": "Hou",
"FirstName": "Gang",
"Affiliation": "Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China."
}
] |
No
|
33545538
|
Prepregnancy antiinflammatory diet in pregnant women with endometriosis: The Japan Environment and Children's Study.
|
Increased risk of preterm birth (PTB) in women with endometriosis is considered to be associated with chronic inflammatory conditions. Accordingly, we hypothesized that a prepregnancy antiinflammatory diet is a potential form of preconception care for preventing PTB in women with endometriosis and conducted this study to investigate the correlation of a prepregnancy antiinflammatory diet with obstetric outcomes in this patient population. We used singleton pregnancy data from the Japan Environment and Children's Study involving live births from 2011 to 2014. Individual meal patterns before pregnancy, derived through food frequency questionnaires, were used to calculate the Dietary Inflammatory Index. Participants were categorized according to Dietary Inflammatory Index quintiles (Q1 and Q5 were the most proinflammatory and antiinflammatory groups, respectively), and a multiple logistic regression model was used to estimate the effect of the antiinflammatory diet on PTB before 37 or 34 wk and on low birth weight (LBW) <2500 or 1500 g. In women who did not undergo assisted reproduction, significantly reduced risk was found in the Q5 group for both PTB at <34 wk significantly decreased (adjusted odds ratio, 0.25; 95% confidence interval, 0.07-0.83) and low birth weight <1500 g (adjusted odds ratio, 0.07; 95% confidence interval, 0.01-0.60). This study suggests a distinct effect of an antiinflammatory diet on more severe obstetric outcomes, specifically PTB before 34 wk and low birth weight <1500 g, for women with endometriosis. Preconception lifestyle can improve perinatal mortality and morbidity among these women.
|
2021 May
|
Nutrition (Burbank, Los Angeles County, Calif.)
|
No DOI
|
[
{
"LastName": "Kyozuka",
"FirstName": "Hyo",
"Affiliation": "Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan; Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan. Electronic address: [email protected]."
},
{
"LastName": "Nishigori",
"FirstName": "Hidekazu",
"Affiliation": "Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan; Fukushima Medical Center for Children and Women, Fukushima, Japan."
},
{
"LastName": "Murata",
"FirstName": "Tsuyoshi",
"Affiliation": "Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan; Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan."
},
{
"LastName": "Fukuda",
"FirstName": "Toma",
"Affiliation": "Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan; Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan."
},
{
"LastName": "Yamaguchi",
"FirstName": "Akiko",
"Affiliation": "Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan; Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan."
},
{
"LastName": "Kanno",
"FirstName": "Aya",
"Affiliation": "Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan; Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan."
},
{
"LastName": "Yasuda",
"FirstName": "Shun",
"Affiliation": "Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan; Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan."
},
{
"LastName": "Sato",
"FirstName": "Akiko",
"Affiliation": "Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan."
},
{
"LastName": "Ogata",
"FirstName": "Yuka",
"Affiliation": "Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan."
},
{
"LastName": "Kuse",
"FirstName": "Masahito",
"Affiliation": "Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan."
},
{
"LastName": "Hosoya",
"FirstName": "Mitsuaki",
"Affiliation": "Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan; Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan."
},
{
"LastName": "Yasumura",
"FirstName": "Seiji",
"Affiliation": "Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan; Department of Public Health, Fukushima Medical University School of Medicine, Fukushima, Japan."
},
{
"LastName": "Hashimoto",
"FirstName": "Koichi",
"Affiliation": "Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan; Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan."
},
{
"LastName": "Fujimori",
"FirstName": "Keiya",
"Affiliation": "Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan; Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan."
}
] |
No
|
35875249
|
Clinical Effect of Emergency Dermabrasion Combined with Biological Dressing A on Wound Microcirculation and Preventing Sepsis in Deep Degree-II Burns.
|
The aim of this study is to explore the clinical effect of emergency dermabrasion combined with biological dressing A on wound microcirculation and preventing sepsis in deep degree-II burns. A total of 90 patients with deep degree-II burns admitted to the hospital were retrospectively enrolled between January 2020 and January 2022. According to different treatment methods, they were divided into the control group (42 cases, biological dressing A) and the observation group (48 cases, emergency dermabrasion combined with biological dressing A). The clinical curative effect in both groups was observed. The wound repair rate and wound healing quality, and changes in levels of wound microcirculation-related indexes (serum epidermal growth factor (EGF), wound blood flow, and partial pressure of transcutaneous oxygen) and inflammatory cytokines (C-reactive protein (CPR), interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR), and procalcitonin (PCT)) before treatment, at 3d and 7d after treatment were compared between the two groups. The incidence of wound infection and sepsis in both groups was recorded. The wound healing time in the observation group was significantly shorter than that in the control group, and wound healing quality in the observation group was better than that in the control group (P < 0.05). At 3 d and 7d after treatment, the levels of serum EGF, wound blood flow and partial pressure of transcutaneous oxygen in both groups were all increased (P < 0.05), which were higher in the observation group than those in the control group (P < 0.05). The levels of CRP, IL-6, ESR, and PCT in both groups were all decreased (P < 0.05), which were lower in the observation group than those in the control group (P < 0.05). There was no significant difference in incidence of sepsis between observation group and control group (4.17% (2/48) vs. 7.14% (3/42)) (Fisher = 0.539). Emergency dermabrasion combined with biological dressing A can effectively improve wound microcirculation in patients with deep degree-II burns, promote wound healing, shorten wound healing time, improve wound healing quality, effectively control inflammatory response, and prevent sepsis.
|
2022
|
Emergency medicine international
|
No DOI
|
[
{
"LastName": "Shao",
"FirstName": "Huawei",
"Affiliation": "Department of Burns & Wound Care Centre, 2nd Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang 310030, China."
},
{
"LastName": "Luo",
"FirstName": "Ru",
"Affiliation": "Department of Pathology, 2nd Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang 310030, China."
},
{
"LastName": "You",
"FirstName": "Chuangang",
"Affiliation": "Department of Burns & Wound Care Centre, 2nd Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang 310030, China."
},
{
"LastName": "Li",
"FirstName": "Qiong",
"Affiliation": "Department of Burns & Wound Care Centre, 2nd Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang 310030, China."
},
{
"LastName": "Mao",
"FirstName": "Shulei",
"Affiliation": "Department of Burns and Plastic Surgery, Zhejiang Quhua Hospital, Quzhou, Zhejiang 324004, China."
}
] |
Yes
|
32251541
|
Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF-1α-BNIP3 Axis.
|
Nucleus pulposus (NP) cells reside in an avascular and hypoxic microenvironment of the intervertebral disc and are predominantly glycolytic due to robust HIF-1 activity. It is generally thought that NP cells contain few functional mitochondria compared with cells that rely on oxidative metabolism. Consequently, the contribution of mitochondria to NP cell metabolism and the role of hypoxia and HIF-1 in mitochondrial homeostasis is poorly understood. Using mitoQC reporter mice, we show for the first time to our knowledge that NP cell mitochondria undergo age-dependent mitophagy in vivo. Mechanistically, in vitro studies suggest that, under hypoxic conditions, mitochondria in primary NP cells undergo HIF-1α-dependent fragmentation, controlled by modulating the levels of key proteins DRP1 and OPA1 that are involved in mitochondrial fission and fusion, respectively. Seahorse assays and steady state metabolic profiling coupled with [1-2-[13] C]-glucose flux analysis revealed that in hypoxia, HIF-1α regulated metabolic flux through coordinating glycolysis and the mitochondrial TCA cycle interactions, thereby controlling the overall biosynthetic capacity of NP cells. We further show that hypoxia and HIF-1α trigger mitophagy in NP cells through the mitochondrial translocation of BNIP3, an inducer of receptor-mediated mitophagy. Surprisingly, however, loss of HIF-1α in vitro and analysis of NP-specific HIF-1α null mice do not show a decrease in mitophagic flux in NP cells but a compensatory increase in NIX and PINK1-Parkin pathways with higher mitochondrial number. Taken together, our studies provide novel mechanistic insights into the complex interplay between hypoxia and HIF-1α signaling on the mitochondrial metabolism and quality control in NP cells. © 2020 American Society for Bone and Mineral Research.
|
2020 Aug
|
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
|
No DOI
|
[
{
"LastName": "Madhu",
"FirstName": "Vedavathi",
"Affiliation": "Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA."
},
{
"LastName": "Boneski",
"FirstName": "Paige K",
"Affiliation": "Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA."
},
{
"LastName": "Silagi",
"FirstName": "Elizabeth",
"Affiliation": "Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA."
},
{
"LastName": "Qiu",
"FirstName": "Yunping",
"Affiliation": "Department of Medicine, Fleischer Institute for Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, NY, USA."
},
{
"LastName": "Kurland",
"FirstName": "Irwin",
"Affiliation": "Department of Medicine, Fleischer Institute for Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, NY, USA."
},
{
"LastName": "Guntur",
"FirstName": "Anyonya R",
"Affiliation": "Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME, USA."
},
{
"LastName": "Shapiro",
"FirstName": "Irving M",
"Affiliation": "Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA."
},
{
"LastName": "Risbud",
"FirstName": "Makarand V",
"Affiliation": "Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA."
}
] |
No
|
24516463
|
Establishment of an inducing medium for type III effector secretion in Xanthomonas campestris pv. campestris.
|
It is well known that the type III secretion system (T3SS) and type III (T3) effectors are essential for the pathogenicity of most bacterial phytopathogens and that the expression of T3SS and T3 effectors is suppressed in rich media but induced in minimal media and plants. To facilitate in-depth studies on T3SS and T3 effectors, it is crucial to establish a medium for T3 effector expression and secretion. Xanthomonas campestris pv. campestris (Xcc) is a model bacterium for studying plant-pathogen interactions. To date no medium for Xcc T3 effector secretion has been defined. Here, we compared four minimal media (MME, MMX, XVM2, and XOM2) which are reported for T3 expression induction in Xanthomonas spp. and found that MME is most efficient for expression and secretion of Xcc T3 effectors. By optimization of carbon and nitrogen sources and pH value based on MME, we established XCM1 medium, which is about 3 times stronger than MME for Xcc T3 effectors secretion. We further optimized the concentration of phosphate, calcium, and magnesium in XCM1 and found that XCM1 with a lower concentration of magnesium (renamed as XCM2) is about 10 times as efficient as XCM1 (meanwhile, about 30 times stronger than MME). Thus, we established an inducing medium XCM2 which is preferred for T3 effector secretion in Xcc.
|
2013
|
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
|
No DOI
|
[
{
"LastName": "Jiang",
"FirstName": "Guo-Feng",
"Affiliation": "Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming, Yunnan, China. ; Graduate School of Chinese Academy of Sciences, Beijing, China."
},
{
"LastName": "Jiang",
"FirstName": "Bo-Le",
"Affiliation": "State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, The Key Laboratory of Ministry of Education for Microbial and Plant Genetic Engineering, and College of Life Science and Technology, Guangxi University, Nanning, Guangxi, China."
},
{
"LastName": "Yang",
"FirstName": "Mei",
"Affiliation": "School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, China."
},
{
"LastName": "Liu",
"FirstName": "San",
"Affiliation": "State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, The Key Laboratory of Ministry of Education for Microbial and Plant Genetic Engineering, and College of Life Science and Technology, Guangxi University, Nanning, Guangxi, China."
},
{
"LastName": "Liu",
"FirstName": "Jiao",
"Affiliation": "State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, The Key Laboratory of Ministry of Education for Microbial and Plant Genetic Engineering, and College of Life Science and Technology, Guangxi University, Nanning, Guangxi, China."
},
{
"LastName": "Liang",
"FirstName": "Xiao-Xia",
"Affiliation": "State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, The Key Laboratory of Ministry of Education for Microbial and Plant Genetic Engineering, and College of Life Science and Technology, Guangxi University, Nanning, Guangxi, China."
},
{
"LastName": "Bai",
"FirstName": "Xian-Fang",
"Affiliation": "State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, The Key Laboratory of Ministry of Education for Microbial and Plant Genetic Engineering, and College of Life Science and Technology, Guangxi University, Nanning, Guangxi, China."
},
{
"LastName": "Tang",
"FirstName": "Dong-Jie",
"Affiliation": "State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, The Key Laboratory of Ministry of Education for Microbial and Plant Genetic Engineering, and College of Life Science and Technology, Guangxi University, Nanning, Guangxi, China."
},
{
"LastName": "Lu",
"FirstName": "Guang-Tao",
"Affiliation": "State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, The Key Laboratory of Ministry of Education for Microbial and Plant Genetic Engineering, and College of Life Science and Technology, Guangxi University, Nanning, Guangxi, China."
},
{
"LastName": "He",
"FirstName": "Yong-Qiang",
"Affiliation": "State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, The Key Laboratory of Ministry of Education for Microbial and Plant Genetic Engineering, and College of Life Science and Technology, Guangxi University, Nanning, Guangxi, China."
},
{
"LastName": "Yu",
"FirstName": "Di-Qiu",
"Affiliation": "Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming, Yunnan, China."
},
{
"LastName": "Tang",
"FirstName": "Ji-Liang",
"Affiliation": "State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, The Key Laboratory of Ministry of Education for Microbial and Plant Genetic Engineering, and College of Life Science and Technology, Guangxi University, Nanning, Guangxi, China."
}
] |
No
|
33468803
|
[A Case Report of P0CY1 Gastric Cancer Achieved Long-Term Survival after Treated with Ramucirumab Monotherapy].
|
The patient was a woman in her early 60s with type 4 advanced cancer which spread throughout the entire stomach. Total gastrectomy with regional lymphadenectomy was performed. She was diagnosed as Stage Ⅳ scirrhous gastric cancer with positive lavage cytology pathologically without any macroscopic peritoneal metastasis(P0CY1). S-1 plus cisplatin therapy was carried out as first-line therapy, but must be stopped after 2 courses because of appetite loss. As the second-line, ramucirumab monotherapy was administered, due to the patient's denial of alopecia and numbness as side effects of paclitaxel. Tumor marker value of CA19-9 remained high 24 months after ramucirumab chemotherapy, but gradually decreased near the normal level with no proof of distant metastasis or peritoneal dissemination. However, after 74 courses, CA19-9 value was elevated and peritoneal dissemination was detected from CT scan. Nivolumab therapy was started as third-line, but only for 5 courses because of indefinite complaints. Afterwards, no chemotherapy has been performed as the patient's request until almost 5 years after surgery. The prognosis of patients with P0CY1 gastric cancer is generally poor, but in our case long-term survival was obtained from ramucirumab therapy only. Recently, ramucirumab monotherapy is administered for advanced HCC patients and expect to be effective in AFP producing gastric cancer. There is an urgent need to elucidate potential predictive biomarkers of ramucirumab efficacy.
|
2020 Dec
|
Gan to kagaku ryoho. Cancer & chemotherapy
|
No DOI
|
[
{
"LastName": "Udagawa",
"FirstName": "Masaru",
"Affiliation": "Dept. of Surgery, JA Toride Medical Center."
},
{
"LastName": "Adikrisna",
"FirstName": "Rama",
"Affiliation": ""
},
{
"LastName": "Yamasaki",
"FirstName": "Yoshimi",
"Affiliation": ""
},
{
"LastName": "Ito",
"FirstName": "Akira",
"Affiliation": ""
},
{
"LastName": "Kobayashi",
"FirstName": "Kenta",
"Affiliation": ""
},
{
"LastName": "Enjoji",
"FirstName": "Megumu",
"Affiliation": ""
},
{
"LastName": "Kirimura",
"FirstName": "Susumu",
"Affiliation": ""
}
] |
Yes
|
38989141
|
Eugenol and lidocaine inhibit voltage-gated Na(+) channels from dorsal root ganglion neurons with different mechanisms.
|
Eugenol (EUG) is a bioactive monoterpenoid used as an analgesic, preservative, and flavoring agent. Our new data show EUG as a voltage-gated Na[+] channel (VGSC) inhibitor, comparable but not identical to lidocaine (LID). EUG inhibits both total and only TTX-R voltage-activated Na[+] currents (INa) recorded from VGSCs naturally expressed on dorsal root ganglion sensory neurons in rats. Inhibition is quick, fully reversible, and dose-dependent. Our biophysical and pharmacological analyses showed that EUG and LID inhibit VGSCs with different mechanisms. EUG inhibits VGSCs with a dose-response relationship characterized by a Hill coefficient of 2, while this parameter for the inhibition by LID is 1. Furthermore, in a different way from LID, EUG modified the voltage dependence of both the VGSC activation and inactivation processes and the recovery from fast inactivated states and the entry to slow inactivated states. In addition, we suggest that EUG, but not LID, interacts with VGSC pre-open-closed states, according to our data.
|
2024
|
Frontiers in pharmacology
|
No DOI
|
[
{
"LastName": "Moreira-Junior",
"FirstName": "Luiz",
"Affiliation": "Department of Anesthesiology, University of Arizona, Tucson, AZ, United States."
},
{
"LastName": "Leal-Cardoso",
"FirstName": "Jose Henrique",
"Affiliation": "Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil."
},
{
"LastName": "Cassola",
"FirstName": "Antonio Carlos",
"Affiliation": "Department of Physiology and Biophysics, Biomedical Sciences Institute, University of Sao Paulo, São Paulo, Brazil."
},
{
"LastName": "Carvalho-de-Souza",
"FirstName": "Joao Luis",
"Affiliation": "Department of Anesthesiology, University of Arizona, Tucson, AZ, United States."
}
] |
No
|
38415045
|
Management of peri-implantitis using local drug delivery among Indian patients.
|
It is of interest to compare 0.2% chlorhexidine gel, 0.2% chlorhexidine chip, minocycline microspheres and slow-release doxycycline gel and tetracycline fibers as drug delivery systems in the management of peri-implantitis. The study comprised of 105 Indian participants who had a minimum of one dental implant with a probing depth of 4 mm, along with exudate and/or bleeding upon probing along with the presence of potentially harmful germs. The use of minocycline microspheres and 0.2% chlorhexidine gel resulted in significant improvements in probing depths at 1 month, 3 months and 6 months and all treatments showed decline in the indicator bacteria. Thus, minocycline microspheres and 0.2% chlorhexidine gel is useful as an adjuvant for mechanical debridement in management of peri-implantitis.
|
2023
|
Bioinformation
|
No DOI
|
[
{
"LastName": "Khare",
"FirstName": "Shilpi",
"Affiliation": "Department of Prosthodontics, Bhabha College of Dental Sciences, Bhopal, M.P., India."
},
{
"LastName": "Doda",
"FirstName": "Hitika P",
"Affiliation": "Midtown Dental Group, New Jersey, USA."
},
{
"LastName": "Dubey",
"FirstName": "Vanya",
"Affiliation": "Department of Oral and Maxillofacial Surgery, Rungta College of Dental Sciences and Research, Kohka Kurud, Bhilai, Chhattisgarh, India."
},
{
"LastName": "Sutaria",
"FirstName": "Shreyansh",
"Affiliation": "Department of Oral Medicine and Radiology, Gujarat University, Gujarat, India."
},
{
"LastName": "Nath",
"FirstName": "Shib Kumar",
"Affiliation": "Department of Orthodontics, The Smile Architect Dental Clinic and Braces Centre, Agartala, Tripura, India."
},
{
"LastName": "Bhatt",
"FirstName": "Drishti",
"Affiliation": "Department of Oral and Maxillofacial Surgery, Divya Jyoti College of Dental Sciences and Research, Modinagar, Uttar Pradesh, India."
},
{
"LastName": "Kumar",
"FirstName": "Santosh",
"Affiliation": "Department of Periodontology, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India."
},
{
"LastName": "Desai",
"FirstName": "Prachi",
"Affiliation": "Oral Pathology and Microbiology, Ahmedabad Dental College and Hospital, Ahmedabad, India."
}
] |
No
|
36648231
|
Wolbachia Promotes Its Own Uptake by Host Cells.
|
Wolbachia pipientis is an incredibly widespread bacterial symbiont of insects, present in an estimated 25 to 52% of species worldwide. Wolbachia is faithfully maternally transmitted both in a laboratory setting and in the wild. In an established infection, Wolbachia is primarily intracellular, residing within host-derived vacuoles that are associated with the endoplasmic reticulum. However, Wolbachia also frequently transfers between host species, requiring an extracellular stage to its life cycle. Indeed, Wolbachia has been moved between insect species for the precise goal of controlling populations. The use of Wolbachia in this application requires that we better understand how it initiates and establishes new infections. Here, we designed a novel method for live tracking Wolbachia cells during infection using a combination of stains and microscopy. We show that live Wolbachia cells are taken up by host cells at a much faster rate than dead Wolbachia cells, indicating that Wolbachia bacteria play a role in their own uptake and that Wolbachia colonization is not just a passive process. We also show that the host actin cytoskeleton must be intact for this to occur and that drugs that disrupt the actin cytoskeleton effectively abrogate Wolbachia uptake. The development of this live infection assay will assist in future efforts to characterize Wolbachia factors used during host infection.
|
2023 Feb 16
|
Infection and immunity
|
No DOI
|
[
{
"LastName": "Nevalainen",
"FirstName": "Lindsay B",
"Affiliation": "Department of Biology, Indiana University, Bloomington, Indiana, USA."
},
{
"LastName": "Layton",
"FirstName": "Emily M",
"Affiliation": "Department of Biology, Indiana University, Bloomington, Indiana, USA."
},
{
"LastName": "Newton",
"FirstName": "Irene L G",
"Affiliation": "Department of Biology, Indiana University, Bloomington, Indiana, USA."
}
] |
No
|
26892272
|
Lupeol enhances inhibitory effect of 5-fluorouracil on human gastric carcinoma cells.
|
Lupeol, a dietary triterpene present in many fruits and medicinal plants, has been reported to possess many pharmacological properties including cancer-preventive and anti-cancer effects in vitro and in vivo. Here, we investigated the anti-cancer efficacy and adjuvant chemotherapy action of lupeol in gastric cancer (GC) cells (SGC7901 and BGC823) and explored the underlying mechanisms. Cells were treated with lupeol and/or 5-fluorouracil (5-Fu) and subjected to cell viability, colony formation, apoptosis, western blot, semiquantitative RT-PCR, and xenograft tumorigenicity assay. Our results showed that lupeol and 5-Fu inhibited the proliferation of SGC7901 and BGC823 cells, and combination treatment with lupeol and 5-Fu resulted in a combination index < 1, indicating a synergistic effect. Co-treatment with lupeol and 5-Fu induced apoptosis through up-regulating the expressions of Bax and p53 and down-regulating the expressions of survivin and Bcl-2. Furthermore, co-treatment displayed more efficient inhibition of tumor weight and volume on BGC823 xenograft mouse model than single-agent treatment with 5-Fu or lupeol. Taken together, our findings highlight that lupeol sensitizes GC to 5-Fu treatment, and combination treatment with lupeol and 5-Fu would be a promising therapeutic strategy for human GC treatment.
|
2016 May
|
Naunyn-Schmiedeberg's archives of pharmacology
|
No DOI
|
[
{
"LastName": "Liu",
"FirstName": "Yan",
"Affiliation": "Department of General Surgery, Wujiang No. 1 People's Hospital, Suzhou, 215200, China."
},
{
"LastName": "Bi",
"FirstName": "Tingting",
"Affiliation": "Department of Geriatric Ward, Wujiang No. 1 People's Hospital, Suzhou, 215200, China."
},
{
"LastName": "Dai",
"FirstName": "Wei",
"Affiliation": "Department of General Surgery, Wujiang No. 1 People's Hospital, Suzhou, 215200, China."
},
{
"LastName": "Wang",
"FirstName": "Gang",
"Affiliation": "Department of General Surgery, Wujiang No. 1 People's Hospital, Suzhou, 215200, China."
},
{
"LastName": "Qian",
"FirstName": "Liqiang",
"Affiliation": "Department of General Surgery, Wujiang No. 1 People's Hospital, Suzhou, 215200, China."
},
{
"LastName": "Shen",
"FirstName": "Genhai",
"Affiliation": "Department of General Surgery, Wujiang No. 1 People's Hospital, Suzhou, 215200, China."
},
{
"LastName": "Gao",
"FirstName": "Quangen",
"Affiliation": "Department of General Surgery, Wujiang No. 1 People's Hospital, Suzhou, 215200, China. [email protected]."
}
] |
Yes
|
36683016
|
Maternal comorbidity index and severe maternal morbidity among medicaid covered pregnant women in a US Southern rural state.
|
The rates of SMM have been steadily increasing in Arkansas, a southern rural state, which has the 5th highest maternal death rate among the US states. The aims of the study were to test the functionality of the Bateman index in association to SMM, in clustering the risks of pregnancies to SMM, and to study the predictability of SMM using the Bateman index. From the ANGELS database, 72,183 pregnancies covered by Medicaid in Arkansas between 2013 and 2016 were included in this study. The expanded CDC ICD-9/ICD-10 criteria were used to identify SMM. The Bateman comorbidity index was applied in quantifying the comorbidity burden for a pregnancy. Multivariable logistic regressions, KMeans method, and five widely used predictive models were applied respectively for each of the study aims. SMM prevalence remained persistently high among Arkansas women covered by Medicaid (195 per 10,000 deliveries) during the study period. Using the Bateman comorbidity index score, the study population was divided into four groups, with a monotonically increasing odds of SMM from a lower score group to a higher score group. The association between the index score and the occurrence of SMM is confirmed with statistical significance: relative to Bateman score falling in 0-1, adjusted Odds Ratios and 95% CIs are: 2.1 (1.78, 2.46) for score in 2-5; 5.08 (3.81, 6.79) for score in 6-9; and 8.53 (4.57, 15.92) for score ≥10. Noticeably, more than one-third of SMM cases were detected from the studied pregnancies that did not have any of the comorbid conditions identified. In the prediction analyses, we observed minimal predictability of SMM using the comorbidity index: the calculated c-statistics ranged between 62% and 67%; the Precision-Recall AUC values are <7% for internal validation and <9% for external validation procedures. The comorbidity index can be used in quantifying the risk of SMM and can help cluster the study population into risk tiers of SMM, especially in rural states where there are disproportionately higher rates of SMM; however, the predictive value of the comorbidity index for SMM is inappreciable.
|
2023 Dec
|
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|
No DOI
|
[
{
"LastName": "Du",
"FirstName": "Ruofei",
"Affiliation": "Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA."
},
{
"LastName": "Ali",
"FirstName": "Mir M",
"Affiliation": "Institute for Digital Health & Innovation, University of Arkansas for Medical Sciences, Little Rock, AR, USA."
},
{
"LastName": "Sung",
"FirstName": "Yi-Shan",
"Affiliation": "Institute for Digital Health & Innovation, University of Arkansas for Medical Sciences, Little Rock, AR, USA."
},
{
"LastName": "Pandit",
"FirstName": "Ambrish A",
"Affiliation": "Division of Pharmaceutical Evaluation and Policy, University of Arkansas for Medical Sciences, Little Rock, AR, USA."
},
{
"LastName": "Payakachat",
"FirstName": "Nalin",
"Affiliation": "Division of Pharmaceutical Evaluation and Policy, University of Arkansas for Medical Sciences, Little Rock, AR, USA."
},
{
"LastName": "Ounpraseuth",
"FirstName": "Songthip T",
"Affiliation": "Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA."
},
{
"LastName": "Magann",
"FirstName": "Everett F",
"Affiliation": "Department of Obstetrics & Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, USA."
},
{
"LastName": "Eswaran",
"FirstName": "Hari",
"Affiliation": "Institute for Digital Health & Innovation, University of Arkansas for Medical Sciences, Little Rock, AR, USA."
}
] |
No
|
27274634
|
Ampelopsis japonica Makino Extract Inhibits the Inflammatory Reaction Induced by Pathogen-Associated Molecular Patterns in Epidermal Keratinocytes.
|
Keratinocytes are the major cells in epidermis, providing barrier components such as cornified cells through the sophisticated differentiation process. In addition, keratinocytes exerts their role as the defense cells via activation of innate immunity. It has been known that pathogen-associated molecular patterns (PAMPs) including double-strand RNA and nucleotides can provoke inflammatory reaction in keratinocytes. The aim of this study is to evaluate the effect of Ampelopsis japonica Makino extract (AE) on PAMPs-induced inflammatory reaction of keratinocytes. The effects of AE were determined using poly (I:C)-induced inflammation and imiquimod-induced psoriasiform dermatitis models. In cultured keratinocytes, AE significantly inhibited poly(I:C)-induced expression of inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor-α. AE significantly inhibited poly(I:C)-induced release of caspase-1 active form (p20), and down-regulated nuclear factor-κB signaling pathway. In imiquimod-induced psoriasiform dermatitis model, topical application of AE resulted in significant reduction of epidermal hyperplasia. These results suggest that AE may be a potential candidate for the treatment of skin inflammation.
|
2016 Jun
|
Annals of dermatology
|
No DOI
|
[
{
"LastName": "Choi",
"FirstName": "Mi-Ra",
"Affiliation": "Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea."
},
{
"LastName": "Choi",
"FirstName": "Dae-Kyoung",
"Affiliation": "Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea."
},
{
"LastName": "Kim",
"FirstName": "Ki-Duck",
"Affiliation": "Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea."
},
{
"LastName": "Kim",
"FirstName": "Sue Jeong",
"Affiliation": "Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea."
},
{
"LastName": "Kim",
"FirstName": "Dong-Il",
"Affiliation": "Department of Obstetrics and Gynecology, Dongguk University College of Korean Medicine, Seoul, Korea."
},
{
"LastName": "Im",
"FirstName": "Myung",
"Affiliation": "Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea."
},
{
"LastName": "Lee",
"FirstName": "Young",
"Affiliation": "Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea."
},
{
"LastName": "Seo",
"FirstName": "Young-Joon",
"Affiliation": "Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea."
},
{
"LastName": "Kim",
"FirstName": "Chang Deok",
"Affiliation": "Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea."
},
{
"LastName": "Lee",
"FirstName": "Jeung-Hoon",
"Affiliation": "Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea.; Skin Med Company, Daejeon, Korea."
}
] |
Yes
|
34512767
|
Mesenchymal Stem Cell Therapy for Alzheimer's Disease.
|
Alzheimer's disease (AD) is a neurodegenerative disease responsible for 60-70% of the 50 million cases of dementia worldwide. It is characterized by neuronal cell death, shrinkage of brain tissue, and progressive cognitive, motor, and behavioral impairment, which often leads to death. Although current treatment has helped improve the patient's quality of life, it has not been able to alter the underlying disease pathology of AD. Studies have shown that mesenchymal stem cells (MSCs)-a group of multipotent stem cells-have the ability to stimulate neuroregeneration and inhibit disease progression. More recently, extracellular vesicles (EVs) from cytokine-preconditioned MSCs have also shown to induce immunomodulatory and neuroprotective effects in AD models. This review will aim to compile pertinent preclinical AD research on transgenic mice as well as clinical trials on MSC-based therapy from diverse sources.
|
2021
|
Stem cells international
|
No DOI
|
[
{
"LastName": "Hernández",
"FirstName": "A E",
"Affiliation": "Facultad de Ciencias de la Salud, Universidad Anáhuac México, Mexico."
},
{
"LastName": "García",
"FirstName": "E",
"Affiliation": "Facultad de Ciencias de la Salud, Universidad Anáhuac México, Mexico."
}
] |
No
|
39039131
|
Reconciling shared versus context-specific information in a neural network model of latent causes.
|
It has been proposed that, when processing a stream of events, humans divide their experiences in terms of inferred latent causes (LCs) to support context-dependent learning. However, when shared structure is present across contexts, it is still unclear how the "splitting" of LCs and learning of shared structure can be simultaneously achieved. Here, we present the Latent Cause Network (LCNet), a neural network model of LC inference. Through learning, it naturally stores structure that is shared across tasks in the network weights. Additionally, it represents context-specific structure using a context module, controlled by a Bayesian nonparametric inference algorithm, which assigns a unique context vector for each inferred LC. Across three simulations, we found that LCNet could (1) extract shared structure across LCs in a function learning task while avoiding catastrophic interference, (2) capture human data on curriculum effects in schema learning, and (3) infer the underlying event structure when processing naturalistic videos of daily events. Overall, these results demonstrate a computationally feasible approach to reconciling shared structure and context-specific structure in a model of LCs that is scalable from laboratory experiment settings to naturalistic settings.
|
2024 Jul 22
|
Scientific reports
|
No DOI
|
[
{
"LastName": "Lu",
"FirstName": "Qihong",
"Affiliation": "Department of Psychology and Princeton Neuroscience Institute, Princeton University, Princeton, USA. [email protected]."
},
{
"LastName": "Nguyen",
"FirstName": "Tan T",
"Affiliation": "Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, USA."
},
{
"LastName": "Zhang",
"FirstName": "Qiong",
"Affiliation": "Department of Psychology and Department of Computer Science, Rutgers University, New Brunswick, USA."
},
{
"LastName": "Hasson",
"FirstName": "Uri",
"Affiliation": "Department of Psychology and Princeton Neuroscience Institute, Princeton University, Princeton, USA."
},
{
"LastName": "Griffiths",
"FirstName": "Thomas L",
"Affiliation": "Department of Psychology and Princeton Neuroscience Institute, Princeton University, Princeton, USA."
},
{
"LastName": "Zacks",
"FirstName": "Jeffrey M",
"Affiliation": "Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, USA."
},
{
"LastName": "Gershman",
"FirstName": "Samuel J",
"Affiliation": "Department of Psychology and Center for Brain Science, Harvard University, Cambridge, USA."
},
{
"LastName": "Norman",
"FirstName": "Kenneth A",
"Affiliation": "Department of Psychology and Princeton Neuroscience Institute, Princeton University, Princeton, USA."
}
] |
No
|
36638607
|
Adversarial Lagrangian integrated contrastive embedding for limited size datasets.
|
Certain datasets contain a limited number of samples with highly various styles and complex structures. This study presents a novel adversarial Lagrangian integrated contrastive embedding (ALICE) method for small-sized datasets. First, the accuracy improvement and training convergence of the proposed pre-trained adversarial transfer are shown on various subsets of datasets with few samples. Second, a novel adversarial integrated contrastive model using various augmentation techniques is investigated. The proposed structure considers the input samples with different appearances and generates a superior representation with adversarial transfer contrastive training. Finally, multi-objective augmented Lagrangian multipliers encourage the low-rank and sparsity of the presented adversarial contrastive embedding to adaptively estimate the coefficients of the regularizers automatically to the optimum weights. The sparsity constraint suppresses less representative elements in the feature space. The low-rank constraint eliminates trivial and redundant components and enables superior generalization. The performance of the proposed model is verified by conducting ablation studies by using benchmark datasets for scenarios with small data samples.
|
2023 Mar
|
Neural networks : the official journal of the International Neural Network Society
|
No DOI
|
[
{
"LastName": "Jalali",
"FirstName": "Amin",
"Affiliation": "KNU-LG Electronics Convergence Research Center, AI Institute of Technology, Kyungpook National University, Daegu, 41566, South Korea. Electronic address: [email protected]."
},
{
"LastName": "Lee",
"FirstName": "Minho",
"Affiliation": "KNU-LG Electronics Convergence Research Center, AI Institute of Technology, Kyungpook National University, Daegu, 41566, South Korea; Graduate School of Artificial Intelligence, Kyungpook National University, Daegu, 41566, South Korea. Electronic address: [email protected]."
}
] |
No
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.