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32547083
|
lncRNA HAND2-AS1 Regulates Prostate Cancer Cell Growth Through Targeting the miR-106a-5p/RBM24 Axis.
|
Increasing evidence has shown that abnormally expressed long non-coding RNA (lncRNA) plays crucial roles in prostate cancer (PCa) progression. Here, we analyzed the expression level of lncRNA HAND2 antisense RNA 1 (HAND2-AS1) in PCa cells and tissues. Function assays were performed to investigate the biological roles of HAND2-AS1 in PCa cell behaviors. Bioinformatics methods, luciferase activity reporter assay, and RNA pull-down assay were performed to validate the connection of microRNA-106a-5p (miR-106a-5p) with HAND2-AS1. Also, the target of miR-106a-5p was explored using the same methods. Our results revealed HAND2-AS1 expression was decreased in both PCa cells and tissues. In vitro functional assays showed HAND2-AS1 could inhibit PCa cell proliferation and colony formation through promoting cell apoptosis. Dual-luciferase activity assays showed miR-106a-5p could directly bind with HAND2-AS1 and RNA binding motif protein 24 (RBM24). Mechanistically, we showed that HAND2-AS1 regulates PCa cell behaviors via targeting miR-106a-5p/RBM24 axis. In summary, our results illustrated that HAND2-AS1 functions as miR-106a-5p sponge to regulate RBM24 expression, and to influence PCa progression.
|
2020
|
OncoTargets and therapy
|
No DOI
|
[
{
"LastName": "Wei",
"FirstName": "Pengtao",
"Affiliation": "Department of Urology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang 471000, People's Republic of China."
},
{
"LastName": "Yang",
"FirstName": "Jing",
"Affiliation": "Central Sterile Supply Department, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China."
},
{
"LastName": "Zhang",
"FirstName": "Dandan",
"Affiliation": "Urinary Surgery, YiDu Central Hospital in Weifang City, Qingzhou, People's Republic of China."
},
{
"LastName": "Cui",
"FirstName": "Meng",
"Affiliation": "Department of Gynecology, Shandong Provincial Maternity and Childcare Hospital, Jinan, People's Republic of China."
},
{
"LastName": "Li",
"FirstName": "Lianjun",
"Affiliation": "Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250014, People's Republic of China."
}
] |
Yes
|
34840600
|
Insulin Topical Application for Wound Healing in Nondiabetic Patients.
|
Low-cost and safe strategies to improve wound healing will be of great social and economic value. The goal of this pilot clinical trial is aimed at analyzing how effective insulin therapy is at healing wounds in nondiabetic people. In this protocol research, 346 individuals were included. Patients were divided as 2 groups at random: experimental patients were given a ten-unit answer. For each 10 cm[2] of wound, insulin was injected in solution with 1 mL 0.9 percent saline, whereas the control group got a standard dressing with normal saline. During the therapy period, no adverse effects were reported. After insulin therapy, no substantial insulin-related side effects were reduced. After 10 days of therapy, the experimental group's granulation tissue coverage rate and thickness were considerably improved as compared to control. Furthermore, a momentous difference in the occurrence of wound bleeding and suppurative wounds between the two groups (P = 0.05). The results of this pilot research suggest that insulin injections could harmless and effective alternative therapy for wound healing in nondiabetic individuals and that larger, placebo-controlled trials are needed to evaluate effectiveness and safety of insulin treatment in wound healing patients.
|
2021
|
Computational and mathematical methods in medicine
|
No DOI
|
[
{
"LastName": "Sun",
"FirstName": "Shudong",
"Affiliation": "Department of Burn and Wound Repair, Weifang People's Hospital, Weifang, Shandong, China."
},
{
"LastName": "Zhang",
"FirstName": "Lei",
"Affiliation": "Department of Burns and Plastic Surgery, Binzhou People's Hospital Binzhou, Shandong, China."
},
{
"LastName": "Liu",
"FirstName": "Jun",
"Affiliation": "Department of Dermatology, Sunshine Union Hospital, Weifang, Shandong, China."
},
{
"LastName": "Li",
"FirstName": "Huiling",
"Affiliation": "Department of Burn and Wound Repair Weifang People's Hospital, Weifang, Shandong, China."
}
] |
Yes
|
34522141
|
The Neutrophil-to-Lymphocyte Ratio (NLR) Predicts the Prognosis of Unresectable Intermediate and Advanced Hepatocellular Carcinoma Treated with Apatinib.
|
Patients with hepatocellular carcinoma (HCC) who might benefit most from anti-angiogenesis therapy remain unknown. In recent years, neutrophil-to-lymphocyte ratio (NLR), an indicator of inflammatory response, has received particular attention in HCC. Herein, we explored the prognostic value of pre-treatment NLR in individuals with unresectable intermediate and advanced hepatocellular carcinoma treated with apatinib, a second-line angiogenesis inhibitor. The findings of this study would assist in precision medicine and provide clinical decision support. This is a retrospective study in which 171 HCC patients attending Tianjin Medical University Cancer Institute and Hospital and treated with apatinib between January 2016 and July 2018 were enrolled. The prognosis of the patients based on NLR signatures was then analyzed. Patients with a low pre-treatment NLR (NLR < 2.49) presented a significantly longer overall survival (OS) (P < 0.001) and progression-free survival (PFS) (P = 0.043). Furthermore, a low pre-treatment NLR level could be used to predict a longer OS in patients with non-macrovascular invasion (P < 0.001). Independent of serum alpha-fetoprotein (AFP) levels, a low NLR level in this cohort of patients is associated with a longer OS. Pre-treatment NLR predicts the prognosis of patients with unresectable intermediate and advanced HCC treated with apatinib.
|
2021
|
Cancer management and research
|
No DOI
|
[
{
"LastName": "Wang",
"FirstName": "Huaqi",
"Affiliation": "Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital; Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, People's Republic of China."
},
{
"LastName": "Wang",
"FirstName": "Zhiwei",
"Affiliation": "Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital; Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, People's Republic of China."
},
{
"LastName": "Hou",
"FirstName": "Zhenyu",
"Affiliation": "Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital; Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, People's Republic of China."
},
{
"LastName": "Yang",
"FirstName": "Xuejiao",
"Affiliation": "Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital; Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, People's Republic of China."
},
{
"LastName": "Zhu",
"FirstName": "Keyun",
"Affiliation": "Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital; Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, People's Republic of China."
},
{
"LastName": "Cao",
"FirstName": "Manqing",
"Affiliation": "Department of Breast Surgery, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People's Republic of China."
},
{
"LastName": "Zhu",
"FirstName": "Xiaolin",
"Affiliation": "Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital; Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, People's Republic of China."
},
{
"LastName": "Li",
"FirstName": "Huikai",
"Affiliation": "Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital; Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, People's Republic of China."
},
{
"LastName": "Zhang",
"FirstName": "Ti",
"Affiliation": "Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital; Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, People's Republic of China."
}
] |
No
|
22078970
|
Removal of oxytetracycline (OTC) in a synthetic pharmaceutical wastewater by a sequential anaerobic multichamber bed reactor (AMCBR)/completely stirred tank reactor (CSTR) system: biodegradation and inhibition kinetics.
|
An anaerobic multichamber bed reactor (AMCBR) was effective in removing both molasses-chemical oxygen demand (COD), and the antibiotic oxytetracycline (OTC). The maximum COD and OTC removals were 99% in sequential AMCBR/completely stirred tank reactor (CSTR) at an OTC concentration of 300 mg L(-1). 51%, 29% and 9% of the total volatile fatty acid (TVFA) was composed of acetic, propionic acid and butyric acids, respectively. The OTC loading rates at between 22.22 and 133.33 g OTC m(-3) d(-1) improved the hydrolysis of molasses-COD (k), the maximum specific utilization of molasses-COD (k(mh)) and the maximum specific utilization rate of TVFA (k(TVFA)). The direct effect of high OTC loadings (155.56 and -177.78 g OTC m(-3) d(-1)) on acidogens and methanogens were evaluated with Haldane inhibition kinetic. A significant decrease of the Haldane inhibition constant was indicative of increases in toxicity at increasing loading rates.
|
2012 Jan
|
Bioresource technology
|
No DOI
|
[
{
"LastName": "Sponza",
"FirstName": "Delia Teresa",
"Affiliation": "Dokuz Eylul University Engineering Faculty, Environmental Engineering Department, Buca Kaynaklar Campus, 35160 Izmir, Turkey. [email protected]"
},
{
"LastName": "Çelebi",
"FirstName": "Hakan",
"Affiliation": ""
}
] |
Yes
|
34712348
|
Changes in the Quality of Life, Psychological Status, Medication Compliance, and Prognosis of Patients with Acute Myocardial Infarction after PCI by Applying PDCA Cycle Management Model.
|
To discuss the changes in the quality of life, psychological status, medication compliance, and prognosis of patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) by applying plan-do-check-action (PDCA) cycle management model. A total of 125 patients with AMI who underwent PCI in our hospital from June 2018 to June 2020 were selected and divided into control group (n = 62) and research group (n = 63) by the random number method. The conventional nursing measures were used in the control group, and the PDCA cycle management model on the basis of the control group was used in the research group. The changes in the quality of life, psychological status, medication compliance, and prognosis were observed. After intervention, the Generic Quality of Life Inventory-74 scores and the self-made medication compliance questionnaire score of the research group were higher than the control group (P < 0.05). After intervention, the self-rating anxiety scale score and self-rating depression scale score of the research group were lower than those of the control group (P < 0.05). The total incidence of adverse events in the research group (7.94%) was lower than that in the control group (20.97%) (P < 0.05). After the application of PDCA cycle management model, the quality of life, psychological status, medication compliance, and prognosis of AMI patients who underwent PCI were improved.
|
2021
|
Evidence-based complementary and alternative medicine : eCAM
|
No DOI
|
[
{
"LastName": "Li",
"FirstName": "Yan",
"Affiliation": "Department of Cardiology, Renmin Hospital of Hubei University of Medicine, Shiyan, Hubei 442000, China."
},
{
"LastName": "Hong",
"FirstName": "Mei",
"Affiliation": "Department of Cardiothoracic Vascular Surgery, Renmin Hospital of Hubei University of Medicine, Shiyan, Hubei 442000, China."
},
{
"LastName": "Liu",
"FirstName": "Guohui",
"Affiliation": "Department of Cardiology, Renmin Hospital of Hubei University of Medicine, Shiyan, Hubei 442000, China."
}
] |
Yes
|
36213012
|
Influence of Pretreatment System on Inorganic Suspended Solids for Influent in Wastewater Treatment Plant.
|
In order to investigate the cause of accumulation of the inorganic suspended solid (ISS) in biochemical tank for wastewater treatment plant (WWTP) in recent years, the influent quality of one WWTP in Chongqing was monitored in one year, and the removal efficiency of ISS during the pretreatment process was studied. Results showed that the low removal efficiency of ISS (<7%) was ascribed to the weak removal efficiency of sand in the grit chamber. The primary sedimentation tank showed a good removal efficiency of ISS up to 69% and also had a good removal efficiency of COD up to 70%. The annual variation rule of MLVSS/MLSS for mixed liquor varied in contrast to the influent quality, ranging from 0.24 to 0.57, much lower than the normal value of 0.7. In order to maintain the normal function of activated sludge, it is necessary to retain the primary sedimentation tank to remove ISS.
|
2022
|
Journal of environmental and public health
|
No DOI
|
[
{
"LastName": "He",
"FirstName": "Li",
"Affiliation": "Zunyi Normal University, Resource and Environment College, Zunyi 563006, China."
},
{
"LastName": "Zhang",
"FirstName": "Yong",
"Affiliation": "Chongqing Research Academy of Environmental Sciences, Chongqing 401147, China."
},
{
"LastName": "Song",
"FirstName": "Dan",
"Affiliation": "Chongqing Research Academy of Environmental Sciences, Chongqing 401147, China."
},
{
"LastName": "Ou",
"FirstName": "Zhongwen",
"Affiliation": "Army Logistics University of PLA, Chongqing 401311, China."
},
{
"LastName": "Xie",
"FirstName": "Zhigang",
"Affiliation": "Chongqing University of Arts and Sciences, Chongqing Key Laboratory of Environmental Materials & Remediation Technologies, Chongqing 402160, China."
},
{
"LastName": "Yang",
"FirstName": "Subo",
"Affiliation": "Chongqing Gangli Limited Corporation, Chongqing 400042, China."
},
{
"LastName": "Guan",
"FirstName": "Wei",
"Affiliation": "Chongqing University of Arts and Sciences, Chongqing Key Laboratory of Environmental Materials & Remediation Technologies, Chongqing 402160, China."
},
{
"LastName": "Dong",
"FirstName": "Cunlan",
"Affiliation": "Chongqing University of Arts and Sciences, Chongqing Key Laboratory of Environmental Materials & Remediation Technologies, Chongqing 402160, China."
},
{
"LastName": "Zhang",
"FirstName": "Yifu",
"Affiliation": "Chongqing University of Arts and Sciences, Chongqing Key Laboratory of Environmental Materials & Remediation Technologies, Chongqing 402160, China."
}
] |
No
|
37862399
|
Pro-Con Debate: Electroencephalography-Guided Anesthesia for Reducing Postoperative Delirium.
|
Postoperative delirium (POD) has significant implications on morbidity, mortality, and health care expenditures. Monitoring electroencephalography (EEG) to adjust anesthetic management has gained interest as a strategy to mitigate POD. In this Pro-Con commentary article, the pro side supports the use of EEG to reduce POD, citing an empiric reduction in POD with processed EEG (pEEG)-guided general anesthesia found in several studies and recent meta-analysis. The Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) trial is the exception to this, and issues with methods and achieved depths are discussed. Meanwhile, the Con side advocates that the use of EEG to reduce POD is not yet certain, citing that there is a lack of evidence that associations between anesthetic depth and POD represent causal relationships. The Con side also contends that the ideal EEG signatures to guide anesthetic titration are currently unknown, and the potential benefits of reduced anesthesia levels may be outweighed by the risks of potentially insufficient anesthetic administration. As the public health burden of POD increases, anesthesia clinicians will be tasked to consider interventions to mitigate risk such as EEG. This Pro-Con debate will provide 2 perspectives on the evidence and rationales for using EEG to mitigate POD.
|
2023 Nov 1
|
Anesthesia and analgesia
|
No DOI
|
[
{
"LastName": "Hao",
"FirstName": "David",
"Affiliation": "From the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts."
},
{
"LastName": "Fritz",
"FirstName": "Bradley A",
"Affiliation": "Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri."
},
{
"LastName": "Saddawi-Konefka",
"FirstName": "Daniel",
"Affiliation": "From the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts."
},
{
"LastName": "Palanca",
"FirstName": "Ben Julian A",
"Affiliation": "Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri."
}
] |
No
|
36999338
|
Volatile sensation: The chemical ecology of the earthy odorant geosmin.
|
Geosmin may be the most familiar volatile compound, as it lends the earthy smell to soil. The compound is a member of the largest family of natural products, the terpenoids. The broad distribution of geosmin among bacteria in both terrestrial and aquatic environments suggests that this compound has an important ecological function, for example, as a signal (attractant or repellent) or as a protective specialized metabolite against biotic and abiotic stresses. While geosmin is part of our everyday life, scientists still do not understand the exact biological function of this omnipresent natural product. This minireview summarizes the current general observations regarding geosmin in prokaryotes and introduces new insights into its biosynthesis and regulation, as well as its biological roles in terrestrial and aquatic environments.
|
2023 Sep
|
Environmental microbiology
|
No DOI
|
[
{
"LastName": "Garbeva",
"FirstName": "Paolina",
"Affiliation": "Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Wageningen, The Netherlands."
},
{
"LastName": "Avalos",
"FirstName": "Mariana",
"Affiliation": "Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands."
},
{
"LastName": "Ulanova",
"FirstName": "Dana",
"Affiliation": "Faculty of Agriculture and Marine Science, Kochi University, 200 Otsu, Monobe, Nankoku, Kochi, 783-8502, Japan."
},
{
"LastName": "van Wezel",
"FirstName": "Gilles P",
"Affiliation": "Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Wageningen, The Netherlands."
},
{
"LastName": "Dickschat",
"FirstName": "Jeroen S",
"Affiliation": "University of Bonn, Kekulé-Institute of Organic Chemistry and Biochemistry, Gerhard-Domagk-Straße 1, 53121, Bonn, Germany."
}
] |
No
|
32398651
|
Acetyl-CoA synthetase 3 promotes bladder cancer cell growth under metabolic stress.
|
Cancer cells adapt to nutrient-deprived tumor microenvironment during progression via regulating the level and function of metabolic enzymes. Acetyl-coenzyme A (AcCoA) is a key metabolic intermediate that is crucial for cancer cell metabolism, especially under metabolic stress. It is of special significance to decipher the role acetyl-CoA synthetase short chain family (ACSS) in cancer cells confronting metabolic stress. Here we analyzed the generation of lipogenic AcCoA in bladder cancer cells under metabolic stress and found that in bladder urothelial carcinoma (BLCA) cells, the proportion of lipogenic AcCoA generated from glucose were largely reduced under metabolic stress. Our results revealed that ACSS3 was responsible for lipogenic AcCoA synthesis in BLCA cells under metabolic stress. Interestingly, we found that ACSS3 was required for acetate utilization and histone acetylation. Moreover, our data illustrated that ACSS3 promoted BLCA cell growth. In addition, through analyzing clinical samples, we found that both mRNA and protein levels of ACSS3 were dramatically upregulated in BLCA samples in comparison with adjacent controls and BLCA patients with lower ACSS3 expression were entitled with longer overall survival. Our data revealed an oncogenic role of ACSS3 via regulating AcCoA generation in BLCA and provided a promising target in metabolic pathway for BLCA treatment.
|
2020 May 12
|
Oncogenesis
|
No DOI
|
[
{
"LastName": "Zhang",
"FirstName": "Jianhao",
"Affiliation": "Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, 450052, China."
},
{
"LastName": "Duan",
"FirstName": "Hongjian",
"Affiliation": "Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, 450052, China."
},
{
"LastName": "Feng",
"FirstName": "Zhipeng",
"Affiliation": "Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, 450052, China."
},
{
"LastName": "Han",
"FirstName": "Xinwei",
"Affiliation": "Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, 450052, China."
},
{
"LastName": "Gu",
"FirstName": "Chaohui",
"Affiliation": "Department of Urology, Henan Institute of Urology and Zhengzhou Key Laboratory for Molecular Biology of Urological Tumor Research, First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, 450052, China. [email protected]."
}
] |
Yes
|
16409294
|
Transactivation of CCL20 gene by Epstein-Barr virus latent membrane protein 1.
|
CCL20 is expected to play a crucial role in the initiation of immune responses and tumour growth. However, expression of CCL20 in Epstein-Barr virus (EBV)-associated diseases has not been studied. We examined the contribution of EBV infection and EBV-encoded latent membrane protein (LMP)-1 to CCL20 expression. EBV infection and LMP-1 induced CCL20 mRNA expression in the EBV-negative Burkitt lymphoma (BL) cell lines and the embryonic kidney cell line. Histone deacetylase inhibitor-stimulated endogenous LMP-1 also induced CCL20 expression in an EBV-positive BL cell line. Analysis of the CCL20 promoter showed that it was activated by LMP-1 C-terminal activation region (CTAR)-1 and CTAR-2. Co-expression of IkappaB alpha, IkappaB beta, IkappaB kinase (IKK)alpha, IKKbeta, IKKgamma, nuclear factor (NF)-kappaB-inducing kinase and tumour necrosis factor receptor-associated factor 2 dominant-negative constructs with LMP-1 inhibited the activation of the CCL20 promoter by LMP-1, suggesting that LMP-1 induces CCL20 via NF-kappaB signalling. The requirement for the NF-kappaB-binding site in the CCL20 promoter in LMP-1 responsiveness was established. Our results indicate that activation of the NF-kappaB pathway by LMP-1 is required for the activation of CCL20 expression.
|
2006 Feb
|
British journal of haematology
|
No DOI
|
[
{
"LastName": "Okudaira",
"FirstName": "Taeko",
"Affiliation": "Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan."
},
{
"LastName": "Yamamoto",
"FirstName": "Kazuo",
"Affiliation": ""
},
{
"LastName": "Kawakami",
"FirstName": "Hirochika",
"Affiliation": ""
},
{
"LastName": "Uchihara",
"FirstName": "Jun-Nosuke",
"Affiliation": ""
},
{
"LastName": "Tomita",
"FirstName": "Mariko",
"Affiliation": ""
},
{
"LastName": "Masuda",
"FirstName": "Masato",
"Affiliation": ""
},
{
"LastName": "Matsuda",
"FirstName": "Takehiro",
"Affiliation": ""
},
{
"LastName": "Sairenji",
"FirstName": "Takeshi",
"Affiliation": ""
},
{
"LastName": "Iha",
"FirstName": "Hidekatsu",
"Affiliation": ""
},
{
"LastName": "Jeang",
"FirstName": "Kuan-Teh",
"Affiliation": ""
},
{
"LastName": "Matsuyama",
"FirstName": "Toshifumi",
"Affiliation": ""
},
{
"LastName": "Takasu",
"FirstName": "Nobuyuki",
"Affiliation": ""
},
{
"LastName": "Mori",
"FirstName": "Naoki",
"Affiliation": ""
}
] |
Yes
|
18707311
|
Fitness components and ecological risk of transgenic release: a model using Japanese medaka (Oryzias latipes).
|
Any release of transgenic organisms into nature is a concern because ecological relationships between genetically engineered organisms and other organisms (including their wild-type conspecifics) are unknown. To address this concern, we developed a method to evaluate risk in which we input estimates of fitness parameters from a founder population into a recurrence model to predict changes in transgene frequency after a simulated transgenic release. With this method, we grouped various aspects of an organism's life cycle into six net fitness components: juvenile viability, adult viability, age at sexual maturity, female fecundity, male fertility, and mating advantage. We estimated these components for wild-type and transgenic individuals using the fish, Japanese medaka (Oryzias latipes). We generalized our model's predictions using various combinations of fitness component values in addition to our experimentally derived estimates. Our model predicted that, for a wide range of parameter values, transgenes could spread in populations despite high juvenile viability costs if transgenes also have sufficiently high positive effects on other fitness components. Sensitivity analyses indicated that transgene effects on age at sexual maturity should have the greatest impact on transgene frequency, followed by juvenile viability, mating advantage, female fecundity, and male fertility, with changes in adult viability, resulting in the least impact.
|
2001 Jul
|
The American naturalist
|
No DOI
|
[
{
"LastName": "Muir",
"FirstName": "W M",
"Affiliation": "Department of Animal Sciences, Purdue University, West Lafayette, Indiana 47907, USA. [email protected]"
},
{
"LastName": "Howard",
"FirstName": "R D",
"Affiliation": ""
}
] |
No
|
35875755
|
Design of IoT Gateway for Crop Growth Environmental Monitoring Based on Edge-Computing Technology.
|
With the extensive use of the Internet of Things (IoT) in agriculture, the number of terminals are also grow rapidly. This will increase the network traffic and computing pressure of the centralized server. The centralized data processing mode used in traditional agriculture cannot meet the needs of the Internet of everything era. This paper designs a gateway based on edge-computing technology for monitoring crop growth environment. It uses virtualized container technology to package long-range wide-area network (LoRaWAN) server, pest identification, and environmental information data fusion functions into images. It forms integrated operation mode of multiple function in agriculture. The gateway applies message-oriented middleware to standardize and customize the data transmission among functional modules, clouds, and edges. Through simulation and field test, the designed gateway can achieve the functions of each module at the same time, the resource utilization, and the transmission quality are stable. The edge-computing gateway has the advantages of low cost, low latency, and low power consumption which has practical significance.
|
2022
|
Computational intelligence and neuroscience
|
No DOI
|
[
{
"LastName": "Dong",
"FirstName": "Mo",
"Affiliation": "College of Biological and Agricultural Engineering, Jilin University, Changchun 130022, Jilin, China."
},
{
"LastName": "Yu",
"FirstName": "Haiye",
"Affiliation": "College of Biological and Agricultural Engineering, Jilin University, Changchun 130022, Jilin, China."
},
{
"LastName": "Sun",
"FirstName": "Zhipeng",
"Affiliation": "Nanchang Automotive Institution of Intelligence & New Energy, Nanchang 330052, Jiangxi, China."
},
{
"LastName": "Wu",
"FirstName": "Mingzhi",
"Affiliation": "Nanchang Automotive Institution of Intelligence & New Energy, Nanchang 330052, Jiangxi, China."
},
{
"LastName": "Zhang",
"FirstName": "Lei",
"Affiliation": "College of Biological and Agricultural Engineering, Jilin University, Changchun 130022, Jilin, China."
},
{
"LastName": "Sui",
"FirstName": "Yuanyuan",
"Affiliation": "College of Biological and Agricultural Engineering, Jilin University, Changchun 130022, Jilin, China."
},
{
"LastName": "Yu",
"FirstName": "Guanghao",
"Affiliation": "Mudanjiang Medical University, Mudanjiang 157000, Heilongjiang, China."
},
{
"LastName": "Han",
"FirstName": "Ting",
"Affiliation": "Mudanjiang Medical University, Mudanjiang 157000, Heilongjiang, China."
},
{
"LastName": "Zhao",
"FirstName": "Ruohan",
"Affiliation": "Mudanjiang Medical University, Mudanjiang 157000, Heilongjiang, China."
}
] |
Yes
|
22984265
|
14-3-3ε and 14-3-3σ inhibit Toll-like receptor (TLR)-mediated proinflammatory cytokine induction.
|
Toll-like receptors (TLRs) are a group of pattern recognition receptors that play a crucial role in the induction of the innate immune response against bacterial and viral infections. TLR3 has emerged as a key sensor of viral double-stranded RNA. Thus, a clearer understanding of the biological processes that modulate TLR3 signaling is essential. Limited studies have applied proteomics toward understanding the dynamics of TLR signaling. Herein, a proteomics approach identified 14-3-3ε and 14-3-3σ proteins as new members of the TLR signaling complex. Toward the functional characterization of 14-3-3ε and 14-3-3σ in TLR signaling, we have shown that both of these proteins impair TLR2, TLR3, TLR4, TLR7/8, and TLR9 ligand-induced IL-6, TNFα, and IFN-β production. We also show that 14-3-3ε and 14-3-3σ impair TLR2-, TLR3-, TLR4-, TLR7/8-, and TLR9-mediated NF-κB and IFN-β reporter gene activity. Interestingly, although the 14-3-3 proteins inhibit poly(I:C)-mediated RANTES production, 14-3-3 proteins augment Pam(3)CSK(4), LPS, R848, and CpG-mediated production of RANTES (regulated on activation normal T cell expressed and secreted) in a Mal (MyD88 adaptor-like)/MyD88-dependent manner. 14-3-3ε and 14-3-3σ also bind to the TLR adaptors and to both TRAF3 and TRAF6. Our study conclusively shows that 14-3-3ε and 14-3-3σ play a major regulatory role in balancing the host inflammatory response to viral and bacterial infections through modulation of the TLR signaling pathway. Thus, manipulation of 14-3-3 proteins may represent novel therapeutic targets for inflammatory conditions and infections.
|
2012 Nov 9
|
The Journal of biological chemistry
|
No DOI
|
[
{
"LastName": "Butt",
"FirstName": "Aisha Qasim",
"Affiliation": "Immune Signaling Group, Institute of Immunology, Department of Biology, National University of Ireland Maynooth, County Kildare, Ireland."
},
{
"LastName": "Ahmed",
"FirstName": "Suaad",
"Affiliation": ""
},
{
"LastName": "Maratha",
"FirstName": "Ashwini",
"Affiliation": ""
},
{
"LastName": "Miggin",
"FirstName": "Sinéad M",
"Affiliation": ""
}
] |
Yes
|
39039124
|
Compatibility and performance study of electrohydrodynamic printing using zinc oxide inkjet ink.
|
The demand for modern electronics and semiconductors has increased throughout the years, which has enabled the innovation and exploration of solution-processed deposition. Solution-based processes have gained a lot of interest due to the low-cost fabrication and the large fabrication areas without the need for high-vacuum equipment. In this study, we utilized the ZnO ink for inkjet printer ink to fabricate a thin film via Electrohydrodynamic printing. Three different ink solutions were prepared for experimentation. The EHD printing technique demonstrated the ink's compatibility with and without the modifications. The outcomes of the EHD printed materials were comparable with the spin-coated thin films. The EHD-printed films demonstrated better results in comparison to spin-coated films. Ra and Rq of the EHD film measured at 3.651 nm and 4.973 nm, respectively. It improved the absorbance up to two-fold at 360 nm wavelength and electrical conductivity up to 40% compared to the spin-coated films. Furthermore, the optimization of the printing parameters can lead to the improved morphology and thickness of the EHD thin films.
|
2024 Jul 22
|
Scientific reports
|
No DOI
|
[
{
"LastName": "Esa",
"FirstName": "Zulfikre",
"Affiliation": "Faculty of Integrated Technologies, Universiti Brunei Darussalam, Bandar Seri Begawan, 1410, Brunei Darussalam."
},
{
"LastName": "Nauman",
"FirstName": "Malik Muhammad",
"Affiliation": "Faculty of Integrated Technologies, Universiti Brunei Darussalam, Bandar Seri Begawan, 1410, Brunei Darussalam. [email protected]."
},
{
"LastName": "Ullah",
"FirstName": "Moiz",
"Affiliation": "Department of Mechanical Engineering, Baluchistan University of Information Technology, Engineering and Management Sciences, Quetta, 87300, Pakistan."
},
{
"LastName": "Khalid",
"FirstName": "Muhammad Usman",
"Affiliation": "College of Computer and Information Sciences, Imam Mohammad Ibn Saud Islamic University, Riyadh, 11564, Saudi Arabia."
},
{
"LastName": "Mehdi",
"FirstName": "Murtuza",
"Affiliation": "Department of Mechanical Engineering, NED University of Engineering and Technology, Karachi, Pakistan."
},
{
"LastName": "Abid",
"FirstName": "Muhammad",
"Affiliation": "Faculty of Integrated Technologies, Universiti Brunei Darussalam, Bandar Seri Begawan, 1410, Brunei Darussalam."
},
{
"LastName": "Iqbal",
"FirstName": "Asif",
"Affiliation": "Faculty of Integrated Technologies, Universiti Brunei Darussalam, Bandar Seri Begawan, 1410, Brunei Darussalam."
},
{
"LastName": "Zaini",
"FirstName": "Juliana Hj",
"Affiliation": "Faculty of Integrated Technologies, Universiti Brunei Darussalam, Bandar Seri Begawan, 1410, Brunei Darussalam."
},
{
"LastName": "Ali",
"FirstName": "Kamran",
"Affiliation": "Faculty of Integrated Technologies, Universiti Brunei Darussalam, Bandar Seri Begawan, 1410, Brunei Darussalam. [email protected]."
}
] |
No
|
21188200
|
Predictors of virological response to a combination therapy with pegylated interferon plus ribavirin including virus and host factors.
|
A combination therapy with pegylated interferon (PEG-IFN) plus ribavirin (RBV) has made it possible to achieve a sustained virological response (SVR) of 50% in refractory cases with genotype 1b and high levels of plasma HCVRNA. Several factors including virus mutation and host factors such as age, gender, fibrosis of the liver, lipid metabolism, innate immunity, and single nucleotide polymorphism (SNPs) are reported to be correlated to therapeutic effects. However, it is difficult to determine which factor is the most important predictor for an individual patient. Data mining analysis is useful for combining all these together to predict the therapeutic effects. It is important to analyze blood tests and to predict therapeutic effects prior to initiating treatment. Since new anti-HCV agents are under development, it will be necessary in the future to select the patients who have a high possibility of achieving SVR if treatment is performed with standard regimen.
|
2010
|
Hepatitis research and treatment
|
No DOI
|
[
{
"LastName": "Izumi",
"FirstName": "Namiki",
"Affiliation": "Department of Gastroenterology and Hepatology, Musashino Red-Cross Hospital, Kyonancho 1-26-1, Musashinoshi, 180-8610 Tokyo, Japan."
},
{
"LastName": "Asahina",
"FirstName": "Yasuhiro",
"Affiliation": ""
},
{
"LastName": "Kurosaki",
"FirstName": "Masayuki",
"Affiliation": ""
}
] |
No
|
36071868
|
Tripeptide Leu-Pro-Phe from Corn Protein Hydrolysates Attenuates Hyperglycemia-Induced Neural Tube Defect in Chicken Embryos.
|
Neural tube defect (NTD) is the most common and severe embryopathy causing embryonic malformation and even death associated with gestational diabetes mellitus (GDM). Leu-Pro-Phe (LPF) is an antioxidative tripeptide isolated from hydrolysates of corn protein. However, the biological activity of LPF in vivo and in vitro remains unclear. This study is aimed at investigating the protective effects of tripeptide LPF against NTD in the high glucose exposure condition and delineate the underlying biological mechanism. We found that LPF alleviated NTD in the high glucose-exposed chicken embryo model. In addition, DF-1 chicken embryo fibroblast was loaded with high glucose for induction of oxidative stress and abnormal O-GlcNAcylation in vitro. LPF significantly decreased accumulation of reactive oxygen species and content of malondialdehyde in DF-1 cells but increased the ratio of reduced glutathione and oxidized glutathione in chick embryo. Oxygen radical absorbance capacity results showed that LPF itself had good free radical scavenging capacity and could enhance antioxidant activity of the cell content. Mechanistic studies suggested that the resistance of LPF to oxidative damage may be related to promotion of NRF2 expression and nuclear translocation. LPF alleviated the overall O-GlcNAcylation level of cellular proteins under high glucose conditions and restored the level of Pax3 protein. Collectively, our findings indicate that LPF peptide could act as a nutritional supplement for the protection of development of embryonic neural tube affected by GDM.
|
2022
|
Oxidative medicine and cellular longevity
|
No DOI
|
[
{
"LastName": "Yan",
"FirstName": "Chang-Yu",
"Affiliation": "Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, Jinan University, Guangzhou 510632, China."
},
{
"LastName": "Sun",
"FirstName": "Jie",
"Affiliation": "Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, Jinan University, Guangzhou 510632, China."
},
{
"LastName": "Yu",
"FirstName": "Gui-Yuan",
"Affiliation": "Perfect (Guangdong) Co., Ltd., Zhongshan 528451, China."
},
{
"LastName": "Liu",
"FirstName": "Jiang-Han-Zi",
"Affiliation": "Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, Jinan University, Guangzhou 510632, China."
},
{
"LastName": "Huang",
"FirstName": "Rong-Ping",
"Affiliation": "Yunnan University of Traditional Chinese Medicine, Kunming 650500, China."
},
{
"LastName": "Han",
"FirstName": "Shao-Cong",
"Affiliation": "Yunnan University of Traditional Chinese Medicine, Kunming 650500, China."
},
{
"LastName": "Zhang",
"FirstName": "Qiong-Yi",
"Affiliation": "Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, Jinan University, Guangzhou 510632, China."
},
{
"LastName": "Li",
"FirstName": "Xiao-Min",
"Affiliation": "Perfect (Guangdong) Co., Ltd., Zhongshan 528451, China."
},
{
"LastName": "Yan",
"FirstName": "Jian-Gang",
"Affiliation": "Perfect (Guangdong) Co., Ltd., Zhongshan 528451, China."
},
{
"LastName": "Kurihara",
"FirstName": "Hiroshi",
"Affiliation": "Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, Jinan University, Guangzhou 510632, China."
},
{
"LastName": "Li",
"FirstName": "Wei-Xi",
"Affiliation": "Yunnan University of Traditional Chinese Medicine, Kunming 650500, China."
},
{
"LastName": "Li",
"FirstName": "Yi-Fang",
"Affiliation": "Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, Jinan University, Guangzhou 510632, China."
},
{
"LastName": "He",
"FirstName": "Rong-Rong",
"Affiliation": "Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, Jinan University, Guangzhou 510632, China."
}
] |
No
|
30250503
|
A Study on Influence of Minivan Front-End Design and Impact Velocity on Pedestrian Thorax Kinematics and Injury Risk.
|
Thoracic injuries occur frequently in minivan-to-pedestrian impact accidents and can cause substantial fatalities. The present research work investigates the human thoracic responses and injury risks in minivan-to-pedestrian impacts, when changing the minivan front-end design and the impact velocity, by using computational biomechanics model. We employed three typical types of minivan model of different front-end designs that are quite popular in Chinese market and considered four impact velocities (20, 30, 40, and 50 km/h). The contact time of car to thorax region (CTCTR), thorax impact velocity, chest deformation, and thoracic injury risks were extracted for the investigation. The results indicate that the predicted pedestrian kinematics, injury responses, and thoracic injury risks are strongly affected by the variation of the minivan front-end design and impact velocity. The pedestrian thoracic injury risks increase with the increasing vehicle impact velocity. It is also revealed that the application of the extra front bumper is beneficial for reducing the thoracic injury risk, and a relatively flatter minivan front-end design gives rise to a higher thoracic injury risk. This study is expected to be served as theoretical references for pedestrian protection design of minivans.
|
2018
|
Applied bionics and biomechanics
|
No DOI
|
[
{
"LastName": "Wang",
"FirstName": "Fang",
"Affiliation": "School of Mechanical and Automotive Engineering, Xiamen University of Technology, Xiamen, China."
},
{
"LastName": "Yu",
"FirstName": "Chao",
"Affiliation": "School of Mechanical and Automotive Engineering, Xiamen University of Technology, Xiamen, China."
},
{
"LastName": "Li",
"FirstName": "Guibing",
"Affiliation": "School of Mechanical Engineering, Hunan University of Science and Technology, Xiangtan, China."
},
{
"LastName": "Han",
"FirstName": "Yong",
"Affiliation": "School of Mechanical and Automotive Engineering, Xiamen University of Technology, Xiamen, China."
},
{
"LastName": "Wang",
"FirstName": "Bingyu",
"Affiliation": "School of Mechanical and Automotive Engineering, Xiamen University of Technology, Xiamen, China."
},
{
"LastName": "Yang",
"FirstName": "Jikuang",
"Affiliation": "Research Center of Vehicle and Traffic Safety (VTS), State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, Hunan University, Changsha, China."
},
{
"LastName": "Lan",
"FirstName": "Diandian",
"Affiliation": "School of Mechanical and Automotive Engineering, Xiamen University of Technology, Xiamen, China."
}
] |
No
|
37815687
|
Implementation and Evaluation of a Curriculum for Ergonomics Training During GI Fellowship.
|
Training in ergonomics is either fragmented or lacking in most GI programs. There are limited real-world data on fellows' perceptions and change in practice after the delivery of a curriculum for ergonomics. We aim to implement a curriculum for endoscopy for our GI fellows and evaluate their response to the same. We devised and implemented a curriculum with three components, delivered over 6 months for all GI fellows in an academic hospital center. These were one, a comprehensive, hour-long didactics session conducted by an experienced faculty member; two, an interactive session with a physical therapist; and three, provision of free resistance bands and compression stockings to fellows. We conducted a pre- and post-curriculum test. Data are presented as proportions and medians with interquartile range. We surveyed 23 fellows. At baseline, 13.6% (3) had sustained ERI during their training. Only 63.6% (14) of trainees reported confidence in being able to recognize signs and symptoms of ERI. Their median self-reported understanding of ergonomics was 3 on a Likert scale of 1-5, corresponding with "average understanding." The majority of trainees had never reviewed any material on ergonomics prior to this curriculum. In the post-test evaluation, the median self-reported understanding of ergonomics improved to 4, corresponding with "above average understanding." All fellows requested a repeat of the curriculum, either semi-annually or annually. Our data show a positive perception of trainees of a practical, reproducible, and low-cost curriculum for endoscopy incorporated during GI fellowship.
|
2023 Dec
|
Digestive diseases and sciences
|
No DOI
|
[
{
"LastName": "Gala",
"FirstName": "Khushboo",
"Affiliation": "Department of Gastroenterology & Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA."
},
{
"LastName": "Ghusn",
"FirstName": "Wissam",
"Affiliation": "Department of Gastroenterology & Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA."
},
{
"LastName": "Coelho-Prabhu",
"FirstName": "Nayantara",
"Affiliation": "Department of Gastroenterology & Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA."
},
{
"LastName": "Wang",
"FirstName": "Xiao Jing",
"Affiliation": "Department of Gastroenterology & Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. [email protected]."
}
] |
No
|
35185969
|
Differential Response of the Photosynthetic Machinery to Fluctuating Light in Mature and Young Leaves of Dendrobium officinale.
|
A key component of photosynthetic electron transport chain, photosystem I (PSI), is susceptible to the fluctuating light (FL) in angiosperms. Cyclic electron flow (CEF) around PSI and water-water cycle (WWC) are both used by the epiphytic orchid Dendrobium officinale to protect PSI under FL. This study examined whether the ontogenetic stage of leaf has an impact on the photoprotective mechanisms dealing with FL. Thus, chlorophyll fluorescence and P700 signals under FL were measured in D. officinale young and mature leaves. Upon transition from dark to actinic light, a rapid re-oxidation of P700 was observed in mature leaves but disappeared in young leaves, indicating that WWC existed in mature leaves but was lacking in young leaves. After shifting from low to high light, PSI over-reduction was clearly missing in mature leaves. By comparison, young leaves showed a transient PSI over-reduction within the first 30 s, which was accompanied with highly activation of CEF. Therefore, the effect of FL on PSI redox state depends on the leaf ontogenetic stage. In mature leaves, WWC is employed to avoid PSI over-reduction. In young leaves, CEF around PSI is enhanced to compensate for the lack of WWC and thus to prevent an uncontrolled PSI over-reduction induced by FL.
|
2021
|
Frontiers in plant science
|
No DOI
|
[
{
"LastName": "Yang",
"FirstName": "Ying-Jie",
"Affiliation": "Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China."
},
{
"LastName": "Shi",
"FirstName": "Qi",
"Affiliation": "Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China."
},
{
"LastName": "Sun",
"FirstName": "Hu",
"Affiliation": "Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China."
},
{
"LastName": "Mei",
"FirstName": "Ren-Qiang",
"Affiliation": "Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China."
},
{
"LastName": "Huang",
"FirstName": "Wei",
"Affiliation": "Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China."
}
] |
No
|
25082240
|
Increased counts and degranulation of duodenal mast cells and eosinophils in functional dyspepsia- a clinical study.
|
Immune factors, especially mast cells and eosinophils, play an important role in the pathogenesis of functional dyspepsia. However, the role of these cells in the duodenum has not been fully understood in patients with functional dyspepsia. We aimed to investigate the infiltration and activation of mast cells and eosinophils in the duodena of subjects with functional dyspepsia. Duodenal biopsies obtained in 48 patients with functional dyspepsia and 21 healthy volunteers were collected for the study. Eosinophils in the bulb (D1) and the descending part (D2) of the duodenum were identified and counted by hematoxylin and eosin (H and E) staining. Major basic protein immunostaining was used to evaluate eosinophil degranulation, as well as mast cells and mast cell degranulation was identified by toluidine blue staining. In the D2 area, compared to controls, functional dyspepsia patients showed a marked increase in eosinophil cell numbers (p=0.008) and eosinophil degranulation rate (p=0.005). Mast cell numbers were significantly increased in patients compared with controls in the D1 (p=0.002) and D2 areas (p less than 0.001), and the degranulation rates of mast cells were significantly increased in functional dyspepsia patients in the D1 (p=0.028) and D2 areas (p=0.044). Duodenal eosinophils and mast cells may be involved in the pathogenesis of functional dyspepsia.
|
2014 Aug
|
Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
|
No DOI
|
[
{
"LastName": "Song",
"FirstName": "Shijun",
"Affiliation": "1Department of General Surgery, China-Japan Union Hospital of Jilin University, Jilin Province, 2Department of Gastroenterology, Taian City Central Hospital, Taian City, Shandong Province; China."
},
{
"LastName": "Song",
"FirstName": "Yan",
"Affiliation": ""
},
{
"LastName": "Zhang",
"FirstName": "Haishan",
"Affiliation": ""
},
{
"LastName": "Li",
"FirstName": "Gaiqin",
"Affiliation": ""
},
{
"LastName": "Li",
"FirstName": "Xiaopei",
"Affiliation": ""
},
{
"LastName": "Wang",
"FirstName": "Xiaohong",
"Affiliation": ""
},
{
"LastName": "Liu",
"FirstName": "Zhen",
"Affiliation": ""
}
] |
Yes
|
24490080
|
Knowledge, Beliefs, and Psychosocial Effect of Acne Vulgaris among Saudi Acne Patients.
|
Objective. This study was conducted to assess the knowledge, beliefs, and psychosocial effect of acne vulgaris among acne patients attending referral dermatology clinic in Al-Khobar city. Material and Methods. A cross-sectional study was conducted on all Saudi acne patients (males and females) attending referral dermatology clinic in Al-Khobar Governmental Hospital. The data were collected by using a structured self-administered questionnaire. Results. Like other studies conducted before, we found that 58.33% of our sample have poor knowledge about factors that affect acne vulgaris with a significant correlation with both age and gender (P = 0.012 and P = 0.031, resp.). There was significant association of reporting affected social activities with age and educational level (P = 0.023 and P = 0.013, resp.). Variation between both genders regarding reporting feeling stressed due to acne was significant (P = 0.001). The majority of our sample sought medical advice after one year. The most commonly used treatment for acne vulgaris before seeking medical help was peeling products. The majority of our patients thought that acne needs no treatment by physicians. Doctors' treatment is considered guaranteed and safe by the vast majority of our patients. Conclusion. This study showed that knowledge about acne is still insufficient among acne patients.
|
2013
|
ISRN dermatology
|
No DOI
|
[
{
"LastName": "Darwish",
"FirstName": "Magdy A",
"Affiliation": "Department of Family and Community Medicine, College of Medicine, University of Dammam, P.O. Box 2114, Dammam 31451, Saudi Arabia."
},
{
"LastName": "Al-Rubaya",
"FirstName": "Ahmed A",
"Affiliation": "Postgraduate Center of Family and Community Medicine, Directorate of Health Affairs, Ministry of Health, Eastern Province, Saudi Arabia."
}
] |
No
|
38252737
|
AOA Critical Issues Symposium: So, You Want to Be a Department Leader: Essentials for Success.
|
Most health systems are vertically integrated, and the leaders of orthopaedic surgery departments or service lines must have a comprehensive understanding of their role in the strategic plan of the health system. Orthopaedic surgery departments must be profitable while supporting the tripartite mission of excellence in clinical care, research, and education. This symposium had 4 specific objectives: to discuss how to (1) create synergy between the department or service line and the health system, (2) develop a strategy to enhance financial stability and revenue growth, (3) develop a comprehensive plan to enhance recruitment and retention of a diverse faculty, and (4) consider alternative strategies to foster education and research, even when the health system may be more focused on revenue generation.
|
2024 May 1
|
The Journal of bone and joint surgery. American volume
|
No DOI
|
[
{
"LastName": "Lieberman",
"FirstName": "J R",
"Affiliation": "Department of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California."
},
{
"LastName": "Boden",
"FirstName": "S D",
"Affiliation": "Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia."
},
{
"LastName": "Pellegrini",
"FirstName": "V D",
"Affiliation": "Department of Orthopaedics, Dartmouth-Hitchcock Medical Center, Hanover, New Hampshire."
},
{
"LastName": "Peabody",
"FirstName": "T D",
"Affiliation": "Department of Orthopaedic Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois."
}
] |
No
|
25635941
|
S-nitrosylation of cofilin-1 mediates estradiol-17β-stimulated endothelial cytoskeleton remodeling.
|
Rapid nitric oxide (NO) production via endothelial NO synthase (eNOS) activation represents a major signaling pathway for the cardiovascular protective effects of estrogens; however, the pathways after NO biosynthesis that estrogens use to function remain largely unknown. Covalent adduction of a NO moiety to cysteines, termed S-nitrosylation (SNO), has emerged as a key route for NO to directly regulate protein function. Cofilin-1 (CFL1) is a small actin-binding protein essential for actin dynamics and cytoskeleton remodeling. Despite being identified as a major SNO protein in endothelial cells, whether SNO regulates CFL-1 function is unknown. We hypothesized that estradiol-17β (E2β) stimulates SNO of CFL1 via eNOS-derived NO and that E2β-induced SNO-CFL1 mediates cytoskeleton remodeling in endothelial cells. Point mutation studies determined Cys80 as the primary SNO site among the 4 cysteines (Cys39/80/139/147) in CFL1. Substitutions of Cys80 with Ala or Ser were used to prepare the SNO-mimetic/deficient (C80A/S) CFL1 mutants. Recombinant wild-type (wt) and mutant CFL1 proteins were prepared; their actin-severing activity was determined by real-time fluorescence imaging analysis. The activity of C80A CFL1 was enhanced to that of the constitutively active S3/A CFL1, whereas the other mutants had no effects. C80A/S mutations lowered Ser3 phosphorylation. Treatment with E2β increased filamentous (F)-actin and filopodium formation in endothelial cells, which were significantly reduced in cells overexpressing wt-CFL. Overexpression of C80A, but not C80S, CFL1 decreased basal F-actin and further suppressed E2β-induced F-actin and filopodium formation compared with wt-CFL1 overexpression. Thus, SNO(Cys80) of cofilin-1 via eNOS-derived NO provides a novel pathway for mediating estrogen-induced endothelial cell cytoskeleton remodeling.
|
2015 Mar
|
Molecular endocrinology (Baltimore, Md.)
|
No DOI
|
[
{
"LastName": "Zhang",
"FirstName": "Hong-hai",
"Affiliation": "Departments of Obstetrics and Gynecology (H-h.Z., T.J.L., T.T., W.W., D.A.W., D-b.C.) and Pathology (T.J.L., D-b.C.), University of California, Irvine, Irvine, California 92697."
},
{
"LastName": "Lechuga",
"FirstName": "Thomas J",
"Affiliation": ""
},
{
"LastName": "Tith",
"FirstName": "Tevy",
"Affiliation": ""
},
{
"LastName": "Wang",
"FirstName": "Wen",
"Affiliation": ""
},
{
"LastName": "Wing",
"FirstName": "Deborah A",
"Affiliation": ""
},
{
"LastName": "Chen",
"FirstName": "Dong-bao",
"Affiliation": ""
}
] |
No
|
12618524
|
Inducible costimulator is essential for collagen-induced arthritis.
|
CD4(+) helper Th cells play a major role in the pathogenesis of rheumatoid arthritis. Th cell activation, differentiation, and immune function are regulated by costimulatory molecules. Inducible costimulator (ICOS) is a novel costimulatory receptor expressed on activated T cells. We, as well as others, recently demonstrated its importance in Th2 cytokine expression and Ab class switching by B cells. In this study, we examined the role of ICOS in rheumatoid arthritis using a collagen-induced arthritis model. We found that ICOS knockout mice on the DBA/1 background were completely resistant to collagen-induced arthritis and exhibited absence of joint tissue inflammation. These mice, when immunized with collagen, exhibited reduced anti-collagen IgM Ab's in the initial stage and IgG2a Ab's at the effector phase of collagen-induced arthritis. Furthermore, ICOS regulates the in vitro and in vivo expression of IL-17, a proinflammatory cytokine implicated in rheumatoid arthritis. These data indicate that ICOS is essential for collagen-induced arthritis and may suggest novel means for treating patients with rheumatoid arthritis.
|
2003 Mar
|
The Journal of clinical investigation
|
No DOI
|
[
{
"LastName": "Nurieva",
"FirstName": "Roza I",
"Affiliation": "Department of Immunology, and. Department of Comparative Medicine, University of Washington School of Medicine, Seattle, Washington, USA."
},
{
"LastName": "Treuting",
"FirstName": "Piper",
"Affiliation": ""
},
{
"LastName": "Duong",
"FirstName": "Julie",
"Affiliation": ""
},
{
"LastName": "Flavell",
"FirstName": "Richard A",
"Affiliation": ""
},
{
"LastName": "Dong",
"FirstName": "Chen",
"Affiliation": ""
}
] |
Yes
|
38855536
|
Analysis of Clinical Trials Using Anti-Tumor Traditional Chinese Medicine Monomers.
|
The potential anti-cancer effect of traditional Chinese medicine (TCM) monomers has been widely studied due to their advantages of well-defined structure, clear therapeutic effects, and easy quality control during the manufacturing process. However, clinical trial information on these monomers is scarce, resulting in a lack of knowledge regarding the research progress, efficacy, and adverse reactions at the clinical stage. Therefore, this study systematically reviewed the clinical trials on the anti-cancer effect of TCM monomers registered in the Clinicaltrials.gov website before 2023.4.30, paying special attention to the trials on tumors, aiming to explore the research results and development prospects in this field. A total of 1982 trials were started using 69 of the 131 TCM monomers. The number of clinical trials performed each year showed an overall upward trend. However, only 26 monomers entered into 519 interventional anti-tumor trials, with vinblastine (194, 37.38%) and camptothecin (146, 28.13%) being the most used. A total of 45 tumors were studied in these 519 trials, with lymphoma (112, 21.58%) being the most frequently studied. Clinical trials are also unevenly distributed across locations and sponsors/collaborators. The location and the sponsor/collaborator with the highest number of performed trials were the United States (651,32.85%) and NIH (77). Therefore, China and its institutions still have large room for progress in promoting TCM monomers in anti-tumor clinical trials. In the next step, priority should be given to the improvement of the research and development ability of domestic enterprises, universities and other institutions, using modern scientific and technological means to solve the problems of poor water solubility and strong toxic and side effects of monomers, so as to promote the clinical research of TCM monomers.
|
2024
|
Drug design, development and therapy
|
No DOI
|
[
{
"LastName": "Lv",
"FirstName": "Dan",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China."
},
{
"LastName": "Liu",
"FirstName": "Yuling",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China."
},
{
"LastName": "Tang",
"FirstName": "Ruying",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China."
},
{
"LastName": "Fu",
"FirstName": "Sai",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China."
},
{
"LastName": "Kong",
"FirstName": "Shasha",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China."
},
{
"LastName": "Liao",
"FirstName": "Qian",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China."
},
{
"LastName": "Li",
"FirstName": "Hui",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China."
},
{
"LastName": "Lin",
"FirstName": "Longfei",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China."
}
] |
No
|
38327035
|
RING finger E3 ligase, RNF138 inhibits osteoblast differentiation by negatively regulating Runx2 protein turnover.
|
A few ubiquitin ligases have been shown to target Runx2, the key osteogenic transcription factor and thereby regulate bone formation. The regulation of Runx2 expression and function are controlled both at the transcriptional and posttranslational levels. Really interesting new gene (RING) finger ubiquitin ligases of which RNF138 is a member are important players in the ubiquitin-proteasome system, contributing to the regulation of protein turnover and cellular processes. Here, we demonstrated that RNF138 negatively correlated with Runx2 protein levels in osteopenic ovariectomized rats which implied its role in bone loss. Accordingly, RNF138 overexpression potently inhibited osteoblast differentiation of mesenchyme-like C3H10T1/2 as well primary rat calvarial osteoblast (RCO) cells in vitro, whereas overexpression of catalytically inactive mutant RNF138Δ18-58 (lacks RING finger domain) had mild to no effect. Contrarily, RNF138 depletion copiously enhanced endogenous Runx2 levels and augmented osteogenic differentiation of C3H10T1/2 as well as RCOs. Mechanistically, RNF138 physically associates within multiple regions of Runx2 and ubiquitinates it leading to its reduced protein stability in a proteasome-dependent manner. Moreover, catalytically active RNF138 destabilized Runx2 which resulted in inhibition of its transactivation potential and physiological function of promoting osteoblast differentiation leading to bone loss. These findings underscore the functional involvement of RNF138 in bone formation which is primarily achieved through its modulation of Runx2 by stimulating ubiquitin-mediated proteasomal degradation. Thus, our findings indicate that RNF138 could be a promising novel target for therapeutic intervention in postmenopausal osteoporosis.
|
2024 May
|
Journal of cellular physiology
|
No DOI
|
[
{
"LastName": "Upadhyay",
"FirstName": "Vishal",
"Affiliation": "Division of Cancer Biology, CSIR-Central Drug Research Institute, Lucknow, Utter Pradesh, India."
},
{
"LastName": "Singh",
"FirstName": "Anil Kumar",
"Affiliation": "Division of Cancer Biology, CSIR-Central Drug Research Institute, Lucknow, Utter Pradesh, India."
},
{
"LastName": "Sharma",
"FirstName": "Shivani",
"Affiliation": "Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India."
},
{
"LastName": "Sethi",
"FirstName": "Arppita",
"Affiliation": "Division of Cancer Biology, CSIR-Central Drug Research Institute, Lucknow, Utter Pradesh, India."
},
{
"LastName": "Srivastava",
"FirstName": "Swati",
"Affiliation": "Division of Cancer Biology, CSIR-Central Drug Research Institute, Lucknow, Utter Pradesh, India."
},
{
"LastName": "Chowdhury",
"FirstName": "Sangita",
"Affiliation": "Division of Cancer Biology, CSIR-Central Drug Research Institute, Lucknow, Utter Pradesh, India."
},
{
"LastName": "Siddiqui",
"FirstName": "Shumaila",
"Affiliation": "Division of Cancer Biology, CSIR-Central Drug Research Institute, Lucknow, Utter Pradesh, India."
},
{
"LastName": "Chattopadhyay",
"FirstName": "Naibedya",
"Affiliation": "Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India."
},
{
"LastName": "Trivedi",
"FirstName": "Arun Kumar",
"Affiliation": "Division of Cancer Biology, CSIR-Central Drug Research Institute, Lucknow, Utter Pradesh, India."
}
] |
No
|
28186466
|
Mental hospital life in the 50s.
|
The recollections of a retired psychiatrist concerning his time as a house doctor in a 1952 Scottish mental hospital. These pertain to early days of the National Health Service. He describes the routines and practices of those times, and he refers to some of his reactions to his experiences.
|
2017 Feb
|
Scottish medical journal
|
No DOI
|
[
{
"LastName": "Bartlet",
"FirstName": "Leslie",
"Affiliation": "Consultant Psychiatrist Emeritus, Southampton University Hospitals, UK."
}
] |
No
|
33816255
|
Overexpressed Tumor Suppressor Exosomal miR-15a-5p in Cancer Cells Inhibits PD1 Expression in CD8+T Cells and Suppresses the Hepatocellular Carcinoma Progression.
|
Hepatocellular carcinoma (HCC) is the most common primary liver tumor, and the main reason is the unclear pathogenesis of HCC, which leads to a high fatality rate of HCC. Therefore, it is of great clinical significance to explore the molecular mechanism of HCC and find a targeted therapeutic approach from the molecular level. MicroRNA-15a-5p (miR-15a-5p) expression level was measured by bioinformatics and qRT-PCR. Luciferase assay and RIP assays were used to verify the relationship between programmed cell death protein 1 (PD1) PD 1 with miR-15a-5p. Exosomes were identified using TEM, Zetasizer Nano ZS, and western blot. Edu, Transwell, and scratch assay were performed to explore the role of miR-15a-5p or exo-miR-15a-5p on HepG2 cells progression. MicroRNA-15a-5p (miR-15a-5p) was decreased in HCC tissues and cell lines, which indicated a poor prognosis. Overexpression of miR-15a-5p inhibited viability, proliferation, migration and invasion of HepG2 cells. Then, we isolated exosomes from cancer cells, and found that miR-15a-5p was packaged into exosomes from cancer cells. Furthermore, exo-miR-15a-5p was secreted into CD8+ T cells, then directly inhibited PD1 expression via targeted binding. Then, we co-cultured CD8+ T cells transfected with PD1 with HepG2 transfected with miR-15a-5p, PD1 remitted the inhibitory role of miR-15a-5p on HCC progression. Together, present study revealed exo-miR-15a-5p from cancer cells inhibited PD1 expression in CD8+ T cells, which suppressed the development of HCC.
|
2021
|
Frontiers in oncology
|
No DOI
|
[
{
"LastName": "Zhang",
"FirstName": "Hong-Yu",
"Affiliation": "Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
},
{
"LastName": "Liang",
"FirstName": "Hong-Xia",
"Affiliation": "Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
},
{
"LastName": "Wu",
"FirstName": "Shu-Huan",
"Affiliation": "Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
},
{
"LastName": "Jiang",
"FirstName": "He-Qing",
"Affiliation": "Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
},
{
"LastName": "Wang",
"FirstName": "Qin",
"Affiliation": "Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
},
{
"LastName": "Yu",
"FirstName": "Zu-Jiang",
"Affiliation": "Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
}
] |
Yes
|
21318151
|
Green tea epigallocatechin gallate exhibits anticancer effect in human pancreatic carcinoma cells via the inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor.
|
The exact molecular mechanism by which epigallocatechin gallate (EGCG) suppresses human pancreatic cancer cell proliferation is unclear. We show here that EGCG-treated pancreatic cancer cells AsPC-1 and BxPC-3 decrease cell adhesion ability on micro-pattern dots, accompanied by dephosphorylations of both focal adhesion kinase (FAK) and insulin-like growth factor-1 receptor (IGF-1R) whereas retained the activations of mitogen-activated protein kinase and mammalian target of rapamycin. The growth of AsPC-1 and BxPC-3 cells can be significantly suppressed by EGCG treatment alone in a dose-dependent manner. At a dose of 100 μM which completely abolishes activations of FAK and IGF-1R, EGCG suppresses more than 50% of cell proliferation without evidence of apoptosis analyzed by PARP cleavage. Finally, the MEK1/2 inhibitor U0126 enhances growth-suppressive effect of EGCG. Our data suggests that blocking FAK and IGF-1R by EGCG could prove valuable for targeted therapy, which can be used in combination with other therapies, for pancreatic cancer.
|
2010
|
Journal of biomedicine & biotechnology
|
No DOI
|
[
{
"LastName": "Vu",
"FirstName": "Hoang Anh",
"Affiliation": "Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, Tokyo, Japan."
},
{
"LastName": "Beppu",
"FirstName": "Yuuichi",
"Affiliation": ""
},
{
"LastName": "Chi",
"FirstName": "Hoang Thanh",
"Affiliation": ""
},
{
"LastName": "Sasaki",
"FirstName": "Kousuke",
"Affiliation": ""
},
{
"LastName": "Yamamoto",
"FirstName": "Hideaki",
"Affiliation": ""
},
{
"LastName": "Xinh",
"FirstName": "Phan Thi",
"Affiliation": ""
},
{
"LastName": "Tanii",
"FirstName": "Takashi",
"Affiliation": ""
},
{
"LastName": "Hara",
"FirstName": "Yukihiko",
"Affiliation": ""
},
{
"LastName": "Watanabe",
"FirstName": "Toshiki",
"Affiliation": ""
},
{
"LastName": "Sato",
"FirstName": "Yuko",
"Affiliation": ""
},
{
"LastName": "Ohdomari",
"FirstName": "Iwao",
"Affiliation": ""
}
] |
No
|
34613980
|
Integrated phosphorus nutrient sources improve wheat yield and phosphorus use efficiency under sub humid conditions.
|
Majority of Pakistani soils are deficient in phosphorus. Phosphorus is usually applied in form of synthetic fertilizer. However integrated use of P from synthetic and organic sources can be more profitable and beneficial on sustainable basis. Field trials were conducted at research farm University of Poonch, Rawalakot, AJK, Pakistan for two consecutive years to check the comparative effects of synthetic fertilizer and organic manures applied alone and in combinations on the phosphorus use efficiency (PUE), wheat yield and yield components. Shafaq-06 cultivar of wheat was used as test cultivar. Ten treatments were included: (I) Control (P0) without application of fertilizer; (II) SSP @ 60 kg/ha (P60SSP); (III) SSP @ 90 kg/ha (P90SSP); (IV) SSP @ 120 kg/ha (P120SSP); (V) PM @60 kg/ha (P60PM); (VI) PM @90 kg/ha (P90PM); (VII) PM @120 kg/ha (P120PM); (VIII) SSP @30 kg/ha + PM @30 kg/ha (P30SSP+30PM); (IX) SSP @45 kg/ha + PM @45 kg/ha (P45SSP+45PM); (X) SSP @60 kg/ha + PM @60 kg/ha (P60SSP+60PM) which were laid out under the Randomized Complete Block Design. Significantly higher values for yield of grain (2397 kg/ha) was recorded with PM + SSP @ 60 kg P2O5 ha-1 each. Likewise, FPUE, PIR of wheat and AFPUE was quite higher with combined use of PM and SSP i.e. P60SSP+60PM treatment. Additionally, increase in PUE, wheat yield and yield components associated with combined treated plot would help to minimize the use of high cost synthetic mineral fertilizers and represents an environmentally and agronomically sound management strategy.
|
2021
|
PloS one
|
No DOI
|
[
{
"LastName": "Mubeen",
"FirstName": "Khuram",
"Affiliation": "Department of Agronomy, MNS University of Agriculture, Multan, Pakistan."
},
{
"LastName": "Wasaya",
"FirstName": "Allah",
"Affiliation": "College of Agriculture, Bahauddin Zakaria University, Multan, Pakistan."
},
{
"LastName": "Rehman",
"FirstName": "Haseeb Ur",
"Affiliation": "Department of Agronomy, Bahauddin Zakaria University, Multan, Pakistan."
},
{
"LastName": "Yasir",
"FirstName": "Tauqeer Ahmad",
"Affiliation": "College of Agriculture, Bahauddin Zakaria University, Multan, Pakistan."
},
{
"LastName": "Farooq",
"FirstName": "Omer",
"Affiliation": "Department of Agronomy, Bahauddin Zakaria University, Multan, Pakistan."
},
{
"LastName": "Imran",
"FirstName": "Muhammad",
"Affiliation": "Department of Soil and Environmental Sciences, MNS University of Agriculture, Multan, Pakistan."
},
{
"LastName": "Ikram",
"FirstName": "Rao Muhammad",
"Affiliation": "Department of Agronomy, MNS University of Agriculture, Multan, Pakistan."
},
{
"LastName": "Nazeer",
"FirstName": "Rabiah",
"Affiliation": "Department of Agronomy, The University of Poonch Rawalakot, Rawalakot, Azad Jammu and Kashmir, Pakistan."
},
{
"LastName": "Zahoor",
"FirstName": "Faisal",
"Affiliation": "Department of Agronomy, The University of Poonch Rawalakot, Rawalakot, Azad Jammu and Kashmir, Pakistan."
},
{
"LastName": "Yonas",
"FirstName": "Muhammad Waqas",
"Affiliation": "Department of Agronomy, MNS University of Agriculture, Multan, Pakistan."
},
{
"LastName": "Aziz",
"FirstName": "Mudassir",
"Affiliation": "Department of Agronomy, MNS University of Agriculture, Multan, Pakistan."
},
{
"LastName": "Habib-Ur-Rahman",
"FirstName": "Muhammad",
"Affiliation": "Department of Agronomy, MNS University of Agriculture, Multan, Pakistan."
},
{
"LastName": "Ahmad",
"FirstName": "Matlob",
"Affiliation": "Department of Agricultural Engineering, Ghazi University, Dera Ghazi Khan, Pakistan."
},
{
"LastName": "Alam",
"FirstName": "Mahmood",
"Affiliation": "Department of Seed Science and Technology, MNS University of Agriculture, Multan, Pakistan."
},
{
"LastName": "Ali",
"FirstName": "Muqarrab",
"Affiliation": "Department of Agronomy, MNS University of Agriculture, Multan, Pakistan."
},
{
"LastName": "Ali",
"FirstName": "Mazhar",
"Affiliation": "Department of Environmental Sciences, COMSATS University Islamabad, Islamabad, Pakistan."
},
{
"LastName": "Khaliq",
"FirstName": "Abdul",
"Affiliation": "Soil and Water Testing Laboratory, Kotla Ahmad Road, Rajanpur, Pakistan."
},
{
"LastName": "Ishtiaq",
"FirstName": "Muhammad",
"Affiliation": "Institute of Plant Protection, MNS University of Agriculture, Multan, Pakistan."
},
{
"LastName": "Waqas",
"FirstName": "Muhammad Mohsin",
"Affiliation": "Department of Agricultural Engineering, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, Pakistan."
}
] |
Yes
|
35833066
|
Focus on the Analysis of the Effect of Solving the Nursing Mode on the Time of the Production Time of the First Maternity and the Subjective Happiness of the Postpartum.
|
Focusing to solve the significance of the nursing mode for preliminary maternity care. Selected 116 first mothers produced in our hospital from January 2010 to January 2022, which were divided into the control group and research group. The two groups each paid conventional care and focused on solving the nursing mode care. Analyze the two groups of pregnancy endings, self-efficacy, negative emotions, subjective happiness, and analgesics. The vaginal delivery rate of the research group was higher than that of the control group, and the cesarean section rate, hospitalization time, and delivery process were lower than the control group (P < 0.05); the amount of bleeding in the postpartum groups increased, but compared with the control group, the increase in bleeding in the research group was smaller (P < 0.05); the research group objective, subjective support, self-evaluation, and subjective happiness index were higher than the control group (P < 0.05). Focusing to solve the nursing model can help the maternal tension relief, the maternal can quickly enter the role, and it plays an important role in establishing a good nursing relationship.
|
2022
|
Contrast media & molecular imaging
|
No DOI
|
[
{
"LastName": "Zhang",
"FirstName": "Tianmin",
"Affiliation": "Characteristic Outpatient Department, Henan Provincial People's Hospital, Zhengzhou 450003, Zhengzhou, China."
},
{
"LastName": "Zhang",
"FirstName": "Lingyun",
"Affiliation": "Obstetrics and Gynaecology, Henan Provincial People's Hospital, Zhengzhou 450003, Zhengzhou, China."
}
] |
Yes
|
36093407
|
Correlation between Collateral Compensation and Homocysteine Levels in Patients with Acute Cerebral Infarction after Intravenous Thrombolysis Based on Medical Big Data.
|
Homocysteine is an amino acid present in plasma, which is an important intermediate product in the metabolism of methionine and cysteine. Acute cerebral infarction (CI) is called acute CI of stroke. It is one of the most common diseases in neurology and has a serious impact, affecting people's lives. This article is aimed at studying the effect of data mining algorithms based on medical big data and the improved apriori algorithm on the analysis of the correlation between collateral compensation and homocysteine levels in patients with acute CI. This article proposes that there are many factors in patients with acute CI, among which are collateral compensation and homocysteine levels that are not easily determined. From the data in the tables in the experiment of this article, it can be seen that the collateral circulation of patients with acute CI is 8%, and the collateral circulation of patients without acute CI is 35%. The results indicate that both collateral compensation and homocysteine levels affect patients with acute CI. The higher the homocysteine level, the greater the probability of acute CI, and the better the state of collateral circulation, the less likely it is to suffer from acute CI.
|
2022
|
BioMed research international
|
No DOI
|
[
{
"LastName": "Zhao",
"FirstName": "Xiaohui",
"Affiliation": "Neurology Department, Xingtai People's Hospital, Xingtai, 054000 Hebei, China."
},
{
"LastName": "Li",
"FirstName": "Fang",
"Affiliation": "Obstetrics Department, Xingtai People's Hospital, Xingtai, 054000 Hebei, China."
},
{
"LastName": "Hu",
"FirstName": "Yanfang",
"Affiliation": "Neurology Department, Xingtai People's Hospital, Xingtai, 054000 Hebei, China."
},
{
"LastName": "Yuan",
"FirstName": "Shaojie",
"Affiliation": "Neurology Department, Xingtai People's Hospital, Xingtai, 054000 Hebei, China."
},
{
"LastName": "Zhang",
"FirstName": "Tong",
"Affiliation": "Neurology Department, Xingtai People's Hospital, Xingtai, 054000 Hebei, China."
},
{
"LastName": "Yang",
"FirstName": "Yu",
"Affiliation": "Pre-Hospital Emergency Department, Xingtai People's Hospital, Xingtai, 054000 Hebei, China."
}
] |
Yes
|
34721631
|
Correlation between NLR, PLR, and LMR and Disease Activity, Efficacy Assessment in Rheumatoid Arthritis.
|
To analyze the value of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR) in the evaluation of disease activity and efficacy in patients with rheumatoid arthritis (RA). The clinical data of 132 newly diagnosed RA patients admitted to our hospital from November 2018 to January 2020 were retrospectively analyzed, and the NLR, PLR, and LMR were calculated. According to the 28-joint disease activity score (DAS28), all patients was divided into the remission group (n = 40) and the active group (n = 92). According to the curative effect of the active group, the patients were divided into the effective group (n = 61) and the ineffective group (n = 39). Logistic regression analysis of clinical data was to determine the influencing factors of RA disease activity. The receiver operating characteristic curve (ROC) was used to evaluate the predictive value of NLR, PLR, and LMR on disease activity and efficacy of RA. The number of cases of smoking history, the number of cases of drinking history, and NLR, PLR, CRP, and ESR levels of patients in the active group were higher than those of the remission group, and the LMR level was lower than that of the remission group; the differences were statistically significant (P < 0.05). The results of multivariate logistic regression analysis showed that NLR, PLR, LMR, CRP, and ESR were independent influencing factors of disease activity in RA patients (P < 0.05). The AUC of NLR, PLR, and LMR on the disease activity of RA patients was 0.872, 0.821, and 0.824, the sensitivity was 87.6%, 70.2%, and 69.3%, and the specificity was 75.6%, 76.8%, and 84.3%, respectively. The NLR and PLR values of the effective group were lower than those of the ineffective group, and the LMR values were higher than those of the ineffective group, and the differences were statistically significant (P < 0.05). The AUC of NLR, PLR, and LMR on the efficacy of RA patients was 0.756, 0.732, and 0.779, the sensitivity was 68.4%, 60.2%, and 67.9%, and the specificity was 83.2%, 86.4%, and 85.1%, respectively. NLR, PLR, and LMR are the independent factors that affect the disease activity of RA patients and can better evaluate the disease activity and efficacy of RA.
|
2021
|
Evidence-based complementary and alternative medicine : eCAM
|
No DOI
|
[
{
"LastName": "Li",
"FirstName": "Mei",
"Affiliation": "The First Affiliated Hospital, Department of Rheumatology and Immunology, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China."
},
{
"LastName": "Xie",
"FirstName": "Lihu",
"Affiliation": "The First Affiliated Hospital, Department of Rheumatology and Immunology, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China."
}
] |
Yes
|
22807382
|
Squash cytomorphology of central neurocytoma: a study of five cases.
|
Intraoperative consultation is an important component in the surgical management of brain tumors. This study was undertaken to describe the cytomorphological features of central neurocytoma (CN) in squash smears. Squash smear of five CNs were reviewed. One to two millimeters of the biopsy material was crushed between two glass slides to make a thin film that was fixed in 95% alcohol and stained with haematoxylin and eosin (H&E). Cytological diagnoses were correlated with clinical and radiological data and finally with histopathological findings in the tumor. We had 5 cases (4 males, 1 female; age, 19-61 years; mean, 32 years). All tumors were located in the lateral ventricle. The smears were highly cellular displaying monomoprhic round tumor cells, round to oval nuclei with evenly distributed finely granular chromatin and ill-defined cytoplasmic borders within fibrillar matrix. Focal rosette formation is also noted. A capillary network was identified in between tumor cells in all the cases. One case had calcification with numerous psamomma bodies identified in the squash smear. The differential diagnosis is discussed. On squash smears, CN can be diagnosed when cytomorphological features are correlated with clinical and radiological finding.
|
2012 Aug
|
Diagnostic cytopathology
|
No DOI
|
[
{
"LastName": "Jaiswal",
"FirstName": "Sushila",
"Affiliation": "Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. [email protected]"
},
{
"LastName": "Vij",
"FirstName": "Mukul",
"Affiliation": ""
},
{
"LastName": "Jaiswal",
"FirstName": "Awadhesh Kumar",
"Affiliation": ""
},
{
"LastName": "Behari",
"FirstName": "Sanjay",
"Affiliation": ""
}
] |
No
|
29937911
|
Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats.
|
Hangover is characterized by a number of unpleasant physical and mental symptoms that occur after heavy alcohol drinking. In addition, consistently excessive alcohol intake is considered as a major reason causes liver disease. The present study investigated the in vivo effects of DA-5513 (Morning care® Kang Hwang) on biological parameters relevant to hangover relief and alcoholic fatty liver. Blood alcohol and acetaldehyde concentrations were determined in rats administered a single dose of alcohol and treated with DA-5513 or commercially available hangover relief beverages (Yeomyung® and Ukon®). The effects of DA-5513 on alcoholic fatty liver were also determined in rats fed alcohol-containing Lieber-DeCarli diets for 4 weeks. Serum liver function markers (aspartate and alanine aminotransferase activities) and serum/liver lipid levels were assessed. Blood alcohol and acetaldehyde concentrations were lower in the groups treated with DA-5513 or Yeomyung®, as compared with control rats. However, Ukon® did not produce any significant effects on these parameters. Treatment with DA-5513 significantly reduced serum aspartate and alanine aminotransferase activities and markedly reduced serum cholesterol and triglyceride levels, as compared with control rats. Histological observations using Oil Red O staining found that DA-5513 delayed the development of alcoholic fatty liver by reversing hepatic fat accumulation. These findings suggest that DA-5513 could have a beneficial effect on alcohol-induced hangovers and has the potential to ameliorate alcoholic fatty liver.
|
2018 Jun
|
Laboratory animal research
|
No DOI
|
[
{
"LastName": "Yu",
"FirstName": "Jae Young",
"Affiliation": "Department of Formulation Development, Dong-A Pharmaceutical Co. Ltd., Yongin, Korea."
},
{
"LastName": "Nguyen",
"FirstName": "Hanh Thuy",
"Affiliation": "College of Pharmacy, Yeungnam University, Gyeongsan, Korea."
},
{
"LastName": "Yong",
"FirstName": "Chul Soon",
"Affiliation": "College of Pharmacy, Yeungnam University, Gyeongsan, Korea."
},
{
"LastName": "Park",
"FirstName": "Hyoung Geun",
"Affiliation": "Department of Formulation Development, Dong-A Pharmaceutical Co. Ltd., Yongin, Korea."
},
{
"LastName": "Jun",
"FirstName": "Joon Ho",
"Affiliation": "Department of Formulation Development, Dong-A Pharmaceutical Co. Ltd., Yongin, Korea."
},
{
"LastName": "Kim",
"FirstName": "Jong Oh",
"Affiliation": "College of Pharmacy, Yeungnam University, Gyeongsan, Korea."
}
] |
Yes
|
38230371
|
3D Kinematics of Male and Female Soccer Players for a Variety of Game-Specific Skills.
|
Soccer is played by a variety of individuals with varying abilities. The complicated lower limb movements involved within the game often lead to knee and ankle injuries, with anterior cruciate ligament injuries being the most severe with regard to rehabilitation time and ongoing health risks. This research explores the biomechanical kinematics of male and female soccer players on synthetic grass to determine whether trends in lower limb biomechanics over a variety of movements could explain injury risk. Both male and female players (n = 10) aged between 19 and 24 years performed running-based and stationary-start movements. Biomechanical measurements at the hip, knee, and ankle were recorded. Observations showed that specific differences in joint angles were largely dependent on the movements performed; however, for male players, on average, across all movements, 84.6% and 72.6% of the variation in joint angles could be explained by internal/external rotation at the hip and knee, respectively. For female players, internal/external knee rotation, as well as hip abduction and adduction, accounted for 83.6% and 80.2% of the variation in joint angles, respectively, across all the tested movements. This highlights the importance of hip mechanics and knee alignment for players when performing a variety of movements.
|
2024
|
Applied bionics and biomechanics
|
No DOI
|
[
{
"LastName": "Loud",
"FirstName": "Danyon",
"Affiliation": "School of Electrical and Mechanical Engineering, The University of Adelaide, Adelaide, SA, Australia."
},
{
"LastName": "Grimshaw",
"FirstName": "Paul",
"Affiliation": "School of Electrical and Mechanical Engineering, The University of Adelaide, Adelaide, SA, Australia."
},
{
"LastName": "Kelso",
"FirstName": "Richard",
"Affiliation": "School of Electrical and Mechanical Engineering, The University of Adelaide, Adelaide, SA, Australia."
}
] |
No
|
32686048
|
Community pharmacists' professional practices for complementary medicines: a qualitative study in New Zealand.
|
Background Complementary medicines are a popular healthcare choice among patients/consumers, and most pharmacies sell these products. Pharmacists are well-placed to advise on complementary medicines, but their training and practices for these products are not optimal. Pharmacists' professional practices for complementary medicines ought to be influenced by professional codes of ethics and standards. Objective To examine community pharmacists' perspectives on complementary medicines in New Zealand, including motivations and justifications for selling these products, and professional and ethical issues complementary medicines raise for pharmacists. Setting Community pharmacists in New Zealand. Method Qualitative, semi-structured interviews with 27 New Zealand practising community pharmacists identified through purposive and convenience sampling. Main outcome measure Participants' views, experiences, and professional practices for complementary medicines. Results Participants struggled to clearly describe products they considered complementary medicines. Perspectives towards these products ranged from strongly supportive to somewhat sceptical; none was strongly opposed. Participants had several motivations for selling complementary medicines, particularly consumer demand and profits. Participants acknowledged ethical issues concerning complementary medicines, including lack of evidence of efficacy and pharmacists' limited training/knowledge. Few referred explicitly to complementary-medicines-related statements in the Pharmacy Council of New Zealand's Code of Ethics, or indicated these guided their practice. Conclusion Participants sold complementary medicines despite having limited knowledge on these products and concerns about efficacy; participants justified this as they believe they are providing an holistic option for patients, and/or ensuring complementary medicines do no harm. Participants were mindful of ethical/professional issues regarding complementary medicines, but were not necessarily aware of, or guided by, explicit statements in the Pharmacy Council of New Zealand's Code of Ethics.
|
2020 Aug
|
International journal of clinical pharmacy
|
No DOI
|
[
{
"LastName": "Barnes",
"FirstName": "Joanne",
"Affiliation": "School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand. [email protected]."
},
{
"LastName": "Butler",
"FirstName": "Rachael",
"Affiliation": ", Auckland, New Zealand."
}
] |
No
|
34262344
|
High-Expression of Cytoplasmic Poly (A) Binding Protein 1 (PABPC1) as a Prognostic Biomarker for Early-Stage Esophageal Squamous Cell Carcinoma.
|
Poly (A) binding protein cytoplasmic 1 (PABPC1) plays a crucial role in the regulation of RNA polyadenylation, translation initiation, and mRNA stability and may be involved in tumorigenesis. Herein, we set out to identify the prognostic value of PABPC1 expression in esophageal squamous cell carcinoma (ESCC). Using quantitative real-time PCR (qRT-PCR) and immunohistochemical analysis, the present study investigated mRNA and protein expressions of PABPC1 in 231 ESCCs and their paired adjacent normal epithelial tissues. We observed a reduction in the average mRNA expression of PABPC1 in ESCC tissue specimen, but the mRNA expression of PABPC1 was significantly higher (P<0.001) in ESCC tissues with high PABPC1 expression and lower (P=0.033) in tissues with low PABPC1 expression. In immunohistochemical analysis, positive expression of the PABPC1 protein was identified in 179 ESCC tissue specimens (179/231, 77.5%), while the percentage of ESCC tissue specimens with high expression of PABPC1 was found to be 41.1% (95/231). PABPC1 expression was found to be significantly correlated with lymph node metastasis (LNM) (P=0.011), pathological stage (P=0.021), tumor recurrence (P<0.001), and the outcome (P<0.001) of patients with ESCC. High expression of PABPC1 was associated with poor overall survival (OS) of ESCC patients (P<0.001) among all pathological stages, particularly in the early stages (pStage-I and -II), and identified to be an independent prognostic factor for OS of patients with ESCC in multivariate analysis (HR=2.622; 95% CI, 1.68-4.129). Comparatively, the expression of Ki-67, p53, and nm23 was not associated with OS. In this study, we discovered that PABPC1 is a prognostic biomarker and a therapeutic target for ESCC, particularly early-stage ESCC.
|
2021
|
Cancer management and research
|
No DOI
|
[
{
"LastName": "Pu",
"FirstName": "Jiangtao",
"Affiliation": "Thoracic Surgery Department of the First Affiliated Hospital, Southwest Medical University, Sichuan, People's Republic of China."
},
{
"LastName": "Zhang",
"FirstName": "Tao",
"Affiliation": "Thoracic Surgery Department of the First Affiliated Hospital, Southwest Medical University, Sichuan, People's Republic of China."
},
{
"LastName": "Zhang",
"FirstName": "Dengguo",
"Affiliation": "Thoracic Surgery Department of the First Affiliated Hospital, Southwest Medical University, Sichuan, People's Republic of China."
},
{
"LastName": "He",
"FirstName": "Kaiming",
"Affiliation": "Thoracic Surgery Department of the First Affiliated Hospital, Southwest Medical University, Sichuan, People's Republic of China."
},
{
"LastName": "Chen",
"FirstName": "Yonghong",
"Affiliation": "Laboratory of Affiliated Hospital of traditional Chinese medicine of Southwest Medical University, Sichuan, People's Republic of China."
},
{
"LastName": "Sun",
"FirstName": "Xingwang",
"Affiliation": "Pathology Department of the First Affiliated Hospital, Southwest Medical University, Sichuan, People's Republic of China."
},
{
"LastName": "Long",
"FirstName": "Wenbo",
"Affiliation": "Pathology Department of the First Affiliated Hospital, Southwest Medical University, Sichuan, People's Republic of China."
}
] |
No
|
34543305
|
The impact of horse purslane (Trianthema portulacastrum L.) infestation on soybean [Glycine max (L.) Merrill] productivity in northern irrigated plains of Pakistan.
|
Horse purslane (Trianthema portulacstrum L.) is an important weed of soybean crop capable of causing significant yield reduction. Therefore, this study assessed the impact of horse purslane and other weeds' infestation on the productivity of soybean. Ten treatments, i.e., weed-free throughout the growing season, horse purslane-free till 20, 40 and 60 days after emergence (DAE), all weeds-free till 20, 40 and 60 DAE, weedy-check (excluding horse purslane), weedy-check (horse purslane alone) and weedy-check (all weeds) were included in the study. Data relating to density and dry weight of recorded weed species, and yield and related traits of soybean were recorded. Overall, infestation percentage of horse purslane was 33.10 and 51%, whereas dry weight was 12 and 44 g m-2 during 1st and 2nd year, respectively. The highest dry weight of all weed species was recorded at 45 DAE in weedy-check all weeds treatment during both years. The lowest relative density and frequency of horse purslane were recorded in the treatment where it was controlled until 20 DAE during 2018 at 30 DAE, whereas the same treatment recoded the lowest density of horse purslane at 45 DAE during 2019. The relative frequency of horse purslane was non-significant for weedy-check horse purslane and weedy-check all weeds treatments during 2018, whereas former treatment had higher relative frequency of horse purslane in weedy-check all weeds than the later during 2019. Yield and related traits significantly differed among different treatments used in the study. The treatment all weeds controlled until 40 DAE recorded higher number of pods per plant, 1000-seed weight and seed yield during both years. The yield reduction in weedy-check treatments was; weedy-check all weeds > weedy-check all weeds except horse purslane > weedy-check horse purslane only. It is concluded that horse purslane was not the sole weed interfering soybean fields and weed flora consisted of false amaranth [Digera muricata (L.) Mart.] and purple nut sedge (Cyperus rotundus L.). Hence, if the soybean fields in northern irrigated plains of Pakistan are infested with horse purslane or heavily infested with horse purslane or other weeds, these should be controlled in initial 40 DAE to improve soybean productivity.
|
2021
|
PloS one
|
No DOI
|
[
{
"LastName": "Mubeen",
"FirstName": "Khuram",
"Affiliation": "Department of Agronomy, MNS University of Agriculture, Multan, Pakistan."
},
{
"LastName": "Shehzad",
"FirstName": "Muhammad",
"Affiliation": "Department of Agronomy, The University of Poonch, Rawalakot, AJK, Pakistan."
},
{
"LastName": "Sarwar",
"FirstName": "Naeem",
"Affiliation": "Department of Agronomy, Bahauddin Zakaria University, Multan, Pakistan."
},
{
"LastName": "Rehman",
"FirstName": "Haseeb Ur",
"Affiliation": "Department of Agronomy, Bahauddin Zakaria University, Multan, Pakistan."
},
{
"LastName": "Yasir",
"FirstName": "Tauqeer Ahmad",
"Affiliation": "College of Agriculture, Bahauddin Zakaria University, Layyah, Pakistan."
},
{
"LastName": "Wasaya",
"FirstName": "Allah",
"Affiliation": "College of Agriculture, Bahauddin Zakaria University, Layyah, Pakistan."
},
{
"LastName": "Ahmad",
"FirstName": "Matlob",
"Affiliation": "Department of Agricultural Engineering and Technology, Ghazi University, Dera Ghazi Khan, Pakistan."
},
{
"LastName": "Hussain",
"FirstName": "Mubshar",
"Affiliation": "Department of Agronomy, Bahauddin Zakaria University, Multan, Pakistan."
},
{
"LastName": "Abbas",
"FirstName": "Muhammad Bilal",
"Affiliation": "Department of Agronomy, MNS University of Agriculture, Multan, Pakistan."
},
{
"LastName": "Yonas",
"FirstName": "Muhammad Waqas",
"Affiliation": "Department of Agronomy, MNS University of Agriculture, Multan, Pakistan."
},
{
"LastName": "Farooq",
"FirstName": "Shahid",
"Affiliation": "Department of Plant Protection, Faculty of Agriculture, Harran University, Şanlıurfa, Turkey."
},
{
"LastName": "Alahmadi",
"FirstName": "Tahani Awad",
"Affiliation": "Department of Pediatrics, College of Medicine, King Saud University, [Medical City], King Khalid University Hospital, Riyadh, Saudi Arabia."
}
] |
Yes
|
34659430
|
LncRNA-URHC Functions as ceRNA to Regulate DNAJB9 Expression by Competitively Binding to miR-5007-3p in Hepatocellular Carcinoma.
|
Hepatocellular carcinoma (HCC) is often diagnosed at a late stage, when the prognosis is poor. The regulation of long noncoding RNAs (lncRNAs) plays a crucial role in HCC. However, the precise regulatory mechanisms of lncRNA signaling in HCC remain largely unknown. Our study aims to investigate the underlying mechanisms of lncRNA (upregulated in hepatocellular carcinoma) URHC in HCC. To study the in vivo and in vitro localization and biological effects of URHC on liver cancer cells. Through bioinformatics analysis, dual-luciferase reporter gene analysis and rescue experiments revealed the possible mechanism of URHC. RT-qPCR, fluorescence in situ hybridization (FISH) staining, EdU, colony formation, and tumor xenograft experiments were used to identify localized and biological effects of URHC on HCC cells in vitro and in vivo. The bioinformatics analysis, dual-luciferase reporter assay, and rescue experiments revealed the potential mechanism of URHC. URHC silencing may inhibit the HCC cells' proliferation in vitro and in vivo. We found that URHC was mainly localized in the cytoplasm. The expression of miR-5007-3p was negatively regulated by URHC. And miR-5007-3p could reverse the effect of URHC in HCC cells. The expression of DNAJB9 was negatively regulated by miR-5007-3p but positively regulated by URHC. These suggestive of lncRNA-URHC positively regulated the level of DNAJB9 by sponging miR-5007-3p. Together, our study elucidated the role of URHC as a miRNA sponge in HCC and shed new light on lncRNA-directed diagnostics and therapeutics in HCC.
|
2021
|
Evidence-based complementary and alternative medicine : eCAM
|
No DOI
|
[
{
"LastName": "Niu",
"FirstName": "Kunwei",
"Affiliation": "Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle Road, Xi'an, Shaanxi 710032, China."
},
{
"LastName": "Qu",
"FirstName": "Shibin",
"Affiliation": "Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle Road, Xi'an, Shaanxi 710032, China."
},
{
"LastName": "Zhang",
"FirstName": "Xuan",
"Affiliation": "Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle Road, Xi'an, Shaanxi 710032, China."
},
{
"LastName": "Dai",
"FirstName": "Jimin",
"Affiliation": "Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle Road, Xi'an, Shaanxi 710032, China."
},
{
"LastName": "Wang",
"FirstName": "Jianlin",
"Affiliation": "Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle Road, Xi'an, Shaanxi 710032, China."
},
{
"LastName": "Nie",
"FirstName": "Ye",
"Affiliation": "Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle Road, Xi'an, Shaanxi 710032, China."
},
{
"LastName": "Zhang",
"FirstName": "Hong",
"Affiliation": "Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle Road, Xi'an, Shaanxi 710032, China."
},
{
"LastName": "Tao",
"FirstName": "Kaishan",
"Affiliation": "Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle Road, Xi'an, Shaanxi 710032, China."
},
{
"LastName": "Song",
"FirstName": "Wenjie",
"Affiliation": "Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle Road, Xi'an, Shaanxi 710032, China."
}
] |
Yes
|
37127344
|
Constant Association between Low High-Density Lipoprotein Cholesterol and Gastric Cancer Regardless of Site.
|
Some epidemiologic factors and body mass index (BMI) have site-specific effects on gastric cancer. The site-specific effect of high-density lipoprotein cholesterol (HDL-C) and hyperglycemia on gastric cancer has not been reported. This study included adults who underwent national gastric cancer screening in 2011 (n=5.49 million). The validation set included gastric cancer patients (n=3,262) and gastric cancer-free persons who underwent health screening (n=14,121) in a single hospital. The site-specific effects of metabolic components and epidemiologic factors on gastric cancer were investigated. Among 5.49 million individuals, 10,417 gastric cancer cases (6,764 non-cardiac gastric cancer [NCGC] and 152 cardiac gastric cancer [CGC]) were detected. BMI was inversely associated with NCGC (P for trend <0.001) but not with CGC. Low HDL-C was associated with both CGC (adjusted odds ratio [aOR], 1.90; 95% confidence interval [CI], 1.34 to 2.71) and NCGC (aOR, 1.41; 95% CI, 1.34 to 1.49). Fasting glucose ≥110 mg/dL was associated with NCGC (aOR, 1.19) and CGC (aOR, 1.50). Men predominance was larger in CGC (aOR, 3.28) than in NCGC (aOR, 1.98). Smoking, alcohol drinking, and family history were associated with NCGC but not with CGC. In the validation set, low HDL-C was associated with CGC (aOR, 2.80) and NCGC (aOR, 2.32). BMI was inversely associated with NCGC (P for trend <0.001), and hyperglycemia was positively associated with both NCGC and CGC. Many epidemiologic factors had site-specific effects on gastric cancer, whereas low HDL-C and hyperglycemia were constantly associated with gastric cancer regardless of the site in two independent sets.
|
2023 Jun 30
|
Journal of obesity & metabolic syndrome
|
No DOI
|
[
{
"LastName": "Nam",
"FirstName": "Su Youn",
"Affiliation": "Department of Gastroenterology, Kyungpook National University Chilgok Hospital, Daegu, Korea."
},
{
"LastName": "Jeong",
"FirstName": "Jihyeon",
"Affiliation": "Department of Statistics, Kyungpook National University, Daegu, Korea."
},
{
"LastName": "Jeon",
"FirstName": "Seong Woo",
"Affiliation": "Department of Gastroenterology, Kyungpook National University Chilgok Hospital, Daegu, Korea."
}
] |
No
|
33609236
|
miR-139-5p promotes neovascularization in diabetic retinopathy by regulating the phosphatase and tensin homolog.
|
Pathological retinal neovascularization is a driver of the progression of diabetic retinopathy (DR). The present study sought to identify the microRNAs (miRNAs) that are differentially expressed during the progression of DR as well as to explore the specific regulatory mechanism of those miRNAs in retinal neovascularization. Using a microarray data set and a diabetic mouse model, it was determined that miR-139-5p was significantly upregulated during the progression of DR. The in vitro investigation revealed an elevation in the miR-139-5p level in both the high glucose (HG)-treated mouse retinal microvascular endothelial cells (mRMECs) and the HG-treated human RMECs (hRMECs). The miR-139-5p overexpression elevated cell migration, facilitated tube formation, and increased vascular endothelial growth factor (VEGF) protein level in the hRMECs. While the angiogenic effect of miR-139-5p overexpression was halted by an anti-VEGF antibody. Meanwhile, the miR-139-5p knockdown eliminated the VEGF-induced cell migration and tube formation in the hRMECs. The phosphatase and tensin homolog (PTEN) was the target gene of the miR-139-5p. PTEN overexpression removed the angiogenic effect of miR-139-5p overexpression, which led to reduced cell migration and tube formation. In the diabetic mice, the miR-139-5p antagomir effectively decreased the acellular capillaries and suppressed the formation of aberrant blood vessels in the retinal tissues. Taken together, miR-139-5p promotes retinal neovascularization by repressing PTEN expression.
|
2021 Feb
|
Archives of pharmacal research
|
No DOI
|
[
{
"LastName": "Zhang",
"FirstName": "Zhongwei",
"Affiliation": "Department of Ophthalmology, Weihai Municipal Hospital, Weihai, 264200, Shandong, China."
},
{
"LastName": "Song",
"FirstName": "Caiping",
"Affiliation": "Department of Ophthalmology, Weihai Municipal Hospital, Weihai, 264200, Shandong, China."
},
{
"LastName": "Wang",
"FirstName": "Tao",
"Affiliation": "Department of Ophthalmology, Weihai Municipal Hospital, Weihai, 264200, Shandong, China."
},
{
"LastName": "Sun",
"FirstName": "Lei",
"Affiliation": "Department of Ophthalmology, Weihai Municipal Hospital, Weihai, 264200, Shandong, China."
},
{
"LastName": "Qin",
"FirstName": "Ling",
"Affiliation": "Department of Ophthalmology, Weihai Municipal Hospital, Weihai, 264200, Shandong, China."
},
{
"LastName": "Ju",
"FirstName": "Jianghua",
"Affiliation": "Department of Endocrinology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, 266035, Shandong, People's Republic of China. [email protected]."
}
] |
No
|
23373383
|
[Substantiation of principles for treatment and prophylaxis of herpes zoster].
|
The ground of principles of treatment and prophylaxis of girdle herpes is resulted in the article. In neurological practice especially actual is a virus of simple herpes of 1th type which causes meningitis, encephalitis, neuritises of cranial nerves, stomatit, and in; the virus of simple herpes of 2th type is caused by meningitis, genital herpes, recidiviruyuschuyu radikulopatiyu; the virus of varicella-zoster causes a windy pox, girdle a herpes, meningitis, encephalitis, neuralgias, neurology, syndrome to Giyena-Barre. It is in-process well-proven that effectively and it is expedient to apply the holiatry of girdle herpes antiviral, kortikosteroidnimi, nesteroidnymi protivovospalitel'nymi preparations, antidepressants, methods of refleksoterapii, and ozonoterapii.
|
2012
|
Likars'ka sprava
|
No DOI
|
[
{
"LastName": "Dovhyĭ",
"FirstName": "I L",
"Affiliation": ""
},
{
"LastName": "Mykyteĭ",
"FirstName": "M O",
"Affiliation": ""
}
] |
No
|
39035186
|
Safe(r)-by-design principles in the thermoplastics industry: guidance on release assessment during manufacture of nano-enabled products.
|
The application of nanomaterials (NMs) and nano-enabled products (NEPs) across many industries has been extensive and is still expanding decades after first being identified as an emerging technology. Additive manufacturing has been greatly impacted and has seen the benefits of integrating NMs within products. With the expansion of nanotechnology, there has been a need to develop more adaptive and responsive methods to ascertain risks and ensure technology is developed safely. The Safe(r)-by-Design (SbD) concept can be used to establish safe parameters and minimise risks during the materials' lifecycle, including the early stages of the supply chain. Exposure monitoring has advanced in recent years with the creation of standardised protocols for occupational exposure assessment of nano-objects and their aggregates and agglomerates (NOAA). To aid in the development of an online SbD-supporting platform by the EU-funded project SAbyNA, we adopt a Europe Standard for monitoring release of NOAA to identify if a greater release of NOAA is associated with incorporation of NMs within NEPs compared to a polymer matrix alone. Case studies included filaments of polypropylene (PP) with nano-Ag or polycarbonate (PC) with single-walled carbon nanotubes (SWCNTs). NMs were received in masterbatch, and therefore previously modified to align with SbD interventions. Results were collected in line with European Standard recommendations: monitoring particle concentrations using direct reading instruments (DRI), sampling for offline chemical and morphological analysis, and collecting contextual information. Based on the criteria described in the European standard (BS EN 17058), data from both case studies identified that inhalation exposure relating to NM was "unlikely". Despite this, during the production of the SWCNT-PC filaments, some noteworthy observations were made, including several DRI activity measurements shown to be higher than background levels, and material morphologically similar to the reference SWCNT/polymeric masterbatch observed in offline analysis. The data collected during this campaign were used to discuss choices available for data interpretation and decision-making in the European Standard for monitoring release of NOAA and also to facilitate the development of SAbyNA's user-friendly industry platform for the SbD of NMs and NEPs.
|
2024
|
Frontiers in public health
|
No DOI
|
[
{
"LastName": "McLean",
"FirstName": "Polly",
"Affiliation": "Institute of Occupational Medicine, Edinburgh, United Kingdom."
},
{
"LastName": "Hanlon",
"FirstName": "James",
"Affiliation": "Institute of Occupational Medicine, Edinburgh, United Kingdom."
},
{
"LastName": "Salmatonidis",
"FirstName": "Apostolos",
"Affiliation": "LEITAT Technological Center, Terrassa, Spain."
},
{
"LastName": "Galea",
"FirstName": "Karen S",
"Affiliation": "Institute of Occupational Medicine, Edinburgh, United Kingdom."
},
{
"LastName": "Brooker",
"FirstName": "Finlay",
"Affiliation": "Institute of Occupational Medicine, Edinburgh, United Kingdom."
},
{
"LastName": "Citterio",
"FirstName": "Cristiano",
"Affiliation": "LATI Industria Termoplastici S.p.A., Vedano Olona, Italy."
},
{
"LastName": "Magni",
"FirstName": "Daniele",
"Affiliation": "LATI Industria Termoplastici S.p.A., Vedano Olona, Italy."
},
{
"LastName": "Vázquez-Campos",
"FirstName": "Socorro",
"Affiliation": "LEITAT Technological Center, Terrassa, Spain."
},
{
"LastName": "Lotti",
"FirstName": "Davide",
"Affiliation": "LATI Industria Termoplastici S.p.A., Vedano Olona, Italy."
},
{
"LastName": "Boyles",
"FirstName": "Matthew S P",
"Affiliation": "Institute of Occupational Medicine, Edinburgh, United Kingdom."
}
] |
No
|
11542874
|
Spectroscopic detection of molecular hydrogen frozen in interstellar ices.
|
A weak infrared absorption feature near 4141 wavenumbers (2.415 micrometers) in the spectrum of WL5, an infrared source in the rho Ophiuchus cloud complex, has been detected. It is attributed to molecular hydrogen created by irradiation and frozen in situ into water-rich ices. A second, broader absorption at 4125 wavenumbers centimeters (2.424 micrometers) is probably due to methanol in the ices. The column densities of frozen molecular hydrogen and methanol are inferred to be about 2.5 x 10(18) and 3.0 x 10(19), respectively. There is about three times more frozen molecular hydrogen than frozen carbon monoxide along this line of sight.
|
1993 Oct 15
|
Science (New York, N.Y.)
|
No DOI
|
[
{
"LastName": "Sandford",
"FirstName": "S A",
"Affiliation": "NASA/Ames Research Center, Moffett Field, CA 94035, USA."
},
{
"LastName": "Allamandola",
"FirstName": "L J",
"Affiliation": ""
},
{
"LastName": "Geballe",
"FirstName": "T R",
"Affiliation": ""
}
] |
Yes
|
25025684
|
The tumor-suppressive microRNA-135b targets c-myc in osteoscarcoma.
|
Osteosarcoma is the most common primary tumor of the bone. It leads to many deaths because of its rapid proliferation and metastasis. Recent studies have shown that microRNAs are important gene regulators that are involved in various cancer-related processes. In this study, we found that miR-135b was down-regulated in both osteoscarcoma patient tumor tissues and osteoscarcoma cell lines in comparison to paired adjacent non-tumor bone tissue. We observed that a lower level of miR-135b was associated with metastasis. The ectopic expression of miR-135b markedly suppressed osteoscarcoma cell proliferation, migration, and invasion. Conversely, the inhibition of miR-135b expression dramatically accelerated cell proliferation, migration, and invasion. The forced expression of miR-135b in osteosarcoma cells resulted in a significant reduction in the protein level of c-Myc and repressed the activity of a luciferase reporter that contained the 3'-untranslated region of the c-Myc mRNA. These effects were abolished by the mutation of the predicted miR-135b-binding site, which indicates that c-Myc may be a miR-135b target gene. Moreover, the ectopic expression of c-Myc partially reversed the inhibition of cell proliferation and invasion that was caused by miR-135b. These data therefore suggest that miR-135b may function as a tumor suppressor to regulate osteosarcoma cell proliferation and invasion through a mechanism that targets the c-Myc oncogene. These findings indicate that miR-135b may play a role in the pathogenesis of osteosarcoma.
|
2014
|
PloS one
|
No DOI
|
[
{
"LastName": "Liu",
"FirstName": "Zheng",
"Affiliation": "Department of Orthopedic Surgery, Peking University Shougang Hospital, Beijing, China."
},
{
"LastName": "Zhang",
"FirstName": "Guangwu",
"Affiliation": "Department of Orthopedic Surgery, Peking University Shougang Hospital, Beijing, China."
},
{
"LastName": "Li",
"FirstName": "Jian",
"Affiliation": "Department of Orthopedic Surgery, Peking University Shougang Hospital, Beijing, China."
},
{
"LastName": "Liu",
"FirstName": "Jiabang",
"Affiliation": "Department of Orthopedic Surgery, Peking University Shougang Hospital, Beijing, China."
},
{
"LastName": "Lv",
"FirstName": "Pengfeng",
"Affiliation": "Department of Orthopedic Surgery, Peking University Shougang Hospital, Beijing, China."
}
] |
Yes
|
21370886
|
Composite polymeric magnetic nanoparticles for co-delivery of hydrophobic and hydrophilic anticancer drugs and MRI imaging for cancer therapy.
|
Exercising complementary roles of polymer-coated magnetic nanoparticles for precise drug delivery and image contrast agents has attracted significant attention in biomedical applications. The objective of this study was to prepare and characterize magnetic nanoparticles embedded in polylactide-co-glycolide matrixes (PLGA-MNPs) as a dual drug delivery and imaging system capable of encapsulating both hydrophilic and hydrophobic drugs. PLGA-MNPs were capable of encapsulating both hydrophobic and hydrophilic drugs in a 2:1 ratio. Biocompatibility, cellular uptake, cytotoxicity, membrane potential, and apoptosis were carried out in two different cancer cell lines (MCF-7 and PANC-1). The molecular basis of induction of apoptosis was validated by Western blotting analysis. For targeted delivery of drugs, targeting ligand such as Herceptin was used, and such a conjugated system demonstrated enhanced cellular uptake and an augmented synergistic effect in an in vitro system when compared with native drugs. Magnetic resonance imaging was carried out both in vitro and in vivo to assess the efficacy of PLGA-MNPs as contrast agents. PLGA-MNPs showed a better contrast effect than commercial contrast agents due to higher T(2) relaxivity with a blood circulation half-life ∼ 47 min in the rat model. Thus, our results demonstrated the dual usable purpose of formulated PLGA-MNPs toward either, in therapeutics by delivering different hydrophobic or hydrophilic drugs individually or in combination and imaging for cancer therapeutics in the near future.
|
2011 Mar
|
ACS applied materials & interfaces
|
No DOI
|
[
{
"LastName": "Singh",
"FirstName": "Abhalaxmi",
"Affiliation": "Laboratory of Nanomedicine, Institute of Life Sciences, Nalco Square, Bhubaneswar -751023, Orissa."
},
{
"LastName": "Dilnawaz",
"FirstName": "Fahima",
"Affiliation": ""
},
{
"LastName": "Mewar",
"FirstName": "Sujeet",
"Affiliation": ""
},
{
"LastName": "Sharma",
"FirstName": "Uma",
"Affiliation": ""
},
{
"LastName": "Jagannathan",
"FirstName": "N R",
"Affiliation": ""
},
{
"LastName": "Sahoo",
"FirstName": "Sanjeeb Kumar",
"Affiliation": ""
}
] |
Yes
|
31692056
|
The circular RNA-NRIP1 plays oncogenic roles by targeting microRNA-505 in the renal carcinoma cell lines.
|
We explored the roles and regulatory mechanisms of the circular RNA (circRNA) nuclear receptor-interacting protein 1 (NRIP1; circNRIP1) in ACHN and CAKI-1 cells. ACHN and CAKI-1 cells were transfected with small-interfering-circNRIP1 (si-circNRIP1) and microRNA-505 (miR-505) inhibitor or the corresponding controls. Cell viability was detected with the Cell Counting Kit-8. The protein expression levels of Bcl-2, Bax, cleaved-caspase-3, matrix metalloproteinase (MMP)-2, MMP-9, adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), protein kinase B (AKT), phosphatidylinositol 3-kinase (PI3K), and mammalian target of rapamycin (mTOR) were individually determined via Western blot. Quantitative reverse transcription polymerase chain reaction was used to examine the expressions of circNRIP1 and miR-505 both in tumor cells and tissues. The apoptotic rate, the colony numbers, and the migration rate were separately determined by the Annexin V-fluorescein isothiocyanate/propidium iodide and flow cytometer, colony formation assay, and migration assay. We found that circNRIP1 was overexpressed in tumor tissue but miR-505 was overproduced. Silencing circZNF292 induced inhibition of cell viability, colony formation, and migration, as well as the activity of AMPK and PI3K/AKT/mTOR cascades but enhancement of apoptosis. si-circNRIP1 stimulated the upregulation of miR-505, whose silence abolished the effects of si-circNRIP1 on these elements mentioned above. In conclusion, the circNRIP1 played oncogenic roles in the ACHN and the CAKI-1 cell lines by targeting miR-505 via stimulating AMPK and PI3K/AKT/mTOR cascades.
|
2020 Mar
|
Journal of cellular biochemistry
|
No DOI
|
[
{
"LastName": "Dong",
"FirstName": "Zhen",
"Affiliation": "Department of Urology and Renal Transplantation, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China."
},
{
"LastName": "Liu",
"FirstName": "Yidong",
"Affiliation": "Department of Urology, Taian City Central Hospital, Taian, Shandong, China."
},
{
"LastName": "Wang",
"FirstName": "Qinghai",
"Affiliation": "Department of Urology and Renal Transplantation, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China."
},
{
"LastName": "Wang",
"FirstName": "Hongyang",
"Affiliation": "Department of Urology and Renal Transplantation, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China."
},
{
"LastName": "Ji",
"FirstName": "Jianlei",
"Affiliation": "Department of Urology and Renal Transplantation, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China."
},
{
"LastName": "Huang",
"FirstName": "Tao",
"Affiliation": "Department of Urology and Renal Transplantation, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China."
},
{
"LastName": "Khanal",
"FirstName": "Aashish",
"Affiliation": "Department of Urology and Renal Transplantation, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China."
},
{
"LastName": "Niu",
"FirstName": "Haitao",
"Affiliation": "Department of Urology and Renal Transplantation, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China."
},
{
"LastName": "Cao",
"FirstName": "Yanwei",
"Affiliation": "Department of Urology and Renal Transplantation, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China."
}
] |
Yes
|
34761630
|
The relationship between types of inflammatory cells located at the micro-environment of papillary thyroid microcarcinoma prognostic factors.
|
To determine the relationship between inflammatory cell types in the microenvironment of papillary thyroid microcarcinoma (PTMC) and prognostic factors. The previous diagnoses and subtypes-variants of 163 patients with papillary thyroid microcarcinoma were re-evaluated according to the 2017 WHO classification. The peritumoral lymphocyte, plasma cell, neutrophil, eosinophil, and mast cell density were classified as none (0.24 mm2), mild (0-10/0.24 mm2), moderate (10-50/0.24 mm2), and severe (˃50/0.24 mm2) under 40x magnification and the relationship with prognostic factors was investigated. There was a statistically significant relationship between tumor capsule invasion (p=0.024) and surgical margin (p=0.049) with mast cell infiltration. A statistically significant relationship was observed between tumor capsule invasion (p=0.0001) and the postoperative disease-free period (p=0.0001) with neutrophil cell infiltration. The postoperative disease-free period of those with neutrophil infiltration was statistically significantly shorter than that of those with no infiltration. The tumor diameter of those with no plasma cells was statistically significantly smaller than that of patients with plasma cells (p=0.003). Closer follow-up of patients with neutrophils, mast cells, and plasma cells, which have been found to be associated with poor prognostic factors in terms of recurrence, lymph node involvement, and distant metastasis, may increase survival.
|
2021 Sep-Oct
|
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
|
No DOI
|
[
{
"LastName": "Kucuk",
"FirstName": "Sirin",
"Affiliation": "Department of Pathology, Faculty of Medicine, Usak University, Usak, Turkey."
},
{
"LastName": "Oltulu",
"FirstName": "Pembe",
"Affiliation": ""
}
] |
No
|
32021279
|
Silencing of Long Non-Coding RNA Colon Cancer-Associated Transcript 2 Inhibits the Growth and Metastasis of Gastric Cancer Through Blocking mTOR Signaling.
|
This study aimed to evaluate the specific role of colon cancer-associated transcript 2 (CCAT2) on gastric cancer (GC), and reveal the potential regulatory mechanism relating to mammalian target of rapamycin (mTOR) signaling. The expression of CCAT2 was detected in GC tissues and cells by quantitative real-time PCR (qRT-PCR), and its relation with the pathologic characteristics of GC patients was analyzed. HGC-27 and SGC-7901 cells were transfected with siRNA-CCAT2 to silence CCAT2, and HGC-27 cells were then treated with an mTOR agonist Leucine (Leu) to activate mTOR signaling. The cell proliferation was evaluated by cell viability and colony formation. The cell cycle and apoptosis, and the migration and invasion abilities were detected by Flow cytometry, and Transwell assay, respectively. The expression of PCNA (proliferation marker), Snail, N-cadherin, E-cadherin (invasion markers), P53, Caspase-8, Bcl-2 (apoptosis markers), LC3-II/LC3-I, ATG3, p62 (autophagy makers), phosphorylated mTOR (p-mTOR), p-AKT, and p-p70S6K (mTOR signaling markers) were detected by Western blot. CCAT2 was upregulated in GC tissues and cells, and positively associated with the maximum tumor diameter, lymphatic metastasis, TNM staging, and low overall survival rate (P < 0.05). siRNA-CCAT2 transfection significantly inhibited the viability, colony formation, and migration and invasion abilities, blocked the cell cycle in G0/G1 phase, and promoted the apoptosis and autophagy of SGC-7901 and HGC-27 cells (P < 0.05). In addition, siRNA-CCAT2 transfection significantly upregulated P53, Caspase-8, LC3-II/LC3-I and ATG3, and downregulated PCNA, Bcl-2, p62, p-mTOR, p-AKT and p-p70S6K in SGC-7901 and HGC-27 cells (P < 0.05). siRNA-CCAT2 reversed the tumor-promoting effect of mTOR signaling activation on HGC-27 cells (P < 0.05). Silencing of CCAT2 inhibited the proliferation, migration and invasion, and promoted the apoptosis and autophagy of GC cells through blocking mTOR signaling.
|
2020
|
OncoTargets and therapy
|
No DOI
|
[
{
"LastName": "Lin",
"FirstName": "Sen",
"Affiliation": "Department of Gastroenterology, The Second Hospital of Shandong University, Jinan City, Shangdong 250033, People's Republic of China."
},
{
"LastName": "Wang",
"FirstName": "Hongbo",
"Affiliation": "Department of Gastroenterology, The Second Hospital of Shandong University, Jinan City, Shangdong 250033, People's Republic of China."
},
{
"LastName": "Yang",
"FirstName": "Wenjuan",
"Affiliation": "Department of Nursing, Jinan Central Hospital, Jinan City, Shangdong 250013, People's Republic of China."
},
{
"LastName": "Wang",
"FirstName": "Aiguang",
"Affiliation": "Department of Oncology, Qianfoshan Hospital of Shandong Province, Jinan City, Shangdong 250014, People's Republic of China."
},
{
"LastName": "Geng",
"FirstName": "Chao",
"Affiliation": "Department of Gastroenterology, Shouguang People's Hospital, Shouguang City, Shangdong 262799, People's Republic of China."
}
] |
Yes
|
26023347
|
Married Women's Sexual Satisfaction Questionnaire; A Developmental and Psychometric Evaluation.
|
Despite the significant contribution of cultural factors to sexual satisfaction, most of the current sexual satisfaction scales pay little attention, if any, to cultural factors and marital status. The current study aimed to develop and validate the Married Women's Sexual Satisfaction Scale. The current methodological study went through three consecutive phases. In the first phase, the concept of sexual satisfaction was defined and analyzed by the hybrid model approach. In the second phase, an item pool was generated by the findings of the first phase. Finally, the psychometric properties of the scale were evaluated in the third phase. All data analyses were performed by the SPSS version 19.0. A 78-item pool was generated based on the findings of the concept analysis phase. After assessing and confirming its face and content validity, 27 items remained in the final version of the scale. The exploratory factor analysis revealed a four-factor structure for the scale. The results of the known-groups comparison showed that females with lower educational status had significantly lower sexual satisfaction. Moreover, there was a significant correlation between the scores of the finalized scale and those of the ENRICH Marital Satisfaction Scale (r = 0.706, P = 0.01). The interclass correlation between the test and the retest measurements was also statistically significant (ICC = 0.939, P value = 0.001). The 27-item Iranian Married Women's Sexual Satisfaction Scale is a simple, valid, and reliable tool to assess married women's sexual satisfaction.
|
2015 Apr
|
Iranian Red Crescent medical journal
|
No DOI
|
[
{
"LastName": "Shahvari",
"FirstName": "Zahra",
"Affiliation": "Department of Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, IR Iran."
},
{
"LastName": "Raisi",
"FirstName": "Firoozeh",
"Affiliation": "Psychiatric and Clinical Psychology Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences (TUMS), Tehran, IR Iran."
},
{
"LastName": "Parsa Yekta",
"FirstName": "Zohre",
"Affiliation": "Department of Medical Surgical, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, IR Iran."
},
{
"LastName": "Ebadi",
"FirstName": "Abbas",
"Affiliation": "Behavioral Sciences Research Center (BSRC), Faculty of Nursing, Baqiyatallah University of Medical Sciences, Tehran, IR Iran."
},
{
"LastName": "Kazemnejad",
"FirstName": "Anoshirvan",
"Affiliation": "Department of Biostatistics, Faculty of Medical Sciences, Tarbiyat Modares University, Tehran, IR Iran."
}
] |
No
|
39025887
|
A noise-reduction algorithm for raw 3D point cloud data of asphalt pavement surface texture.
|
High-precision 3D point cloud data have various analyses and application use cases. This study aimed to achieve a more precise noise reduction of the raw 3D point cloud data of asphalt pavements obtained using 3D laser scanning. Hence, a noise-reduction algorithm integrating improved Gaussian filtering and coefficient of variation was developed. A portable laser scanner was used to collect raw, high-precision 3D point cloud data of surface textures from pavement slab samples prepared with three different types of asphalt mixtures: AC-13, SMA-13, and OGFC-13, as well as asphalt from the test sections of the Yakang Expressway. An improved Gaussian filtering and Gaussian filtering that extracts noise using the coefficient of variation were used to filter out the obvious outlier noise and small-scale burr noise, respectively. Finally, the filtering effect of the proposed algorithm, Gaussian filtering, median filtering, and mean filtering on raw 3D point cloud data of pavement textures was evaluated through subjective visual quality and objective index evaluations. The results showed that the proposed algorithm filters out noise while preserving the micro-texture structure information, outperforming Gaussian filtering, median filtering, and mean filtering.
|
2024 Jul 18
|
Scientific reports
|
No DOI
|
[
{
"LastName": "Ding",
"FirstName": "Shihai",
"Affiliation": "School of Architecture and Civil Engineering, Chengdu University, Chengdu, 610106, Sichuan, China."
},
{
"LastName": "Chen",
"FirstName": "Xiaoping",
"Affiliation": "School of Architecture and Civil Engineering, Chengdu University, Chengdu, 610106, Sichuan, China. [email protected]."
},
{
"LastName": "Ai",
"FirstName": "Changfa",
"Affiliation": "College of Civil Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, China."
},
{
"LastName": "Wang",
"FirstName": "Jingang",
"Affiliation": "School of Architecture and Civil Engineering, Chengdu University, Chengdu, 610106, Sichuan, China."
},
{
"LastName": "Yang",
"FirstName": "Huaping",
"Affiliation": "School of Architecture and Civil Engineering, Chengdu University, Chengdu, 610106, Sichuan, China."
}
] |
No
|
26276795
|
Implementation factors affecting the large-scale deployment of digital health and well-being technologies: A qualitative study of the initial phases of the 'Living-It-Up' programme.
|
Little is known about the factors which facilitate or impede the large-scale deployment of health and well-being consumer technologies. The Living-It-Up project is a large-scale digital intervention led by NHS 24, aiming to transform health and well-being services delivery throughout Scotland. We conducted a qualitative study of the factors affecting the implementation and deployment of the Living-It-Up services. We collected a range of data during the initial phase of deployment, including semi-structured interviews (N = 6); participant observation sessions (N = 5) and meetings with key stakeholders (N = 3). We used the Normalisation Process Theory as an explanatory framework to interpret the social processes at play during the initial phases of deployment.Initial findings illustrate that it is clear - and perhaps not surprising - that the size and diversity of the Living-It-Up consortium made implementation processes more complex within a 'multi-stakeholder' environment. To overcome these barriers, there is a need to clearly define roles, tasks and responsibilities among the consortium partners. Furthermore, varying levels of expectations and requirements, as well as diverse cultures and ways of working, must be effectively managed. Factors which facilitated implementation included extensive stakeholder engagement, such as co-design activities, which can contribute to an increased 'buy-in' from users in the long term. An important lesson from the Living-It-Up initiative is that attempting to co-design innovative digital services, but at the same time, recruiting large numbers of users is likely to generate conflicting implementation priorities which hinder - or at least substantially slow down - the effective rollout of services at scale.The deployment of Living-It-Up services is ongoing, but our results to date suggest that - in order to be successful - the roll-out of digital health and well-being technologies at scale requires a delicate and pragmatic trade-off between co-design activities, the development of innovative services and the efforts allocated to widespread marketing and recruitment initiatives.
|
2016 Dec
|
Health informatics journal
|
No DOI
|
[
{
"LastName": "Agbakoba",
"FirstName": "Ruth",
"Affiliation": "University of Glasgow, UK."
},
{
"LastName": "McGee-Lennon",
"FirstName": "Marilyn",
"Affiliation": "University of Glasgow, UK."
},
{
"LastName": "Bouamrane",
"FirstName": "Matt-Mouley",
"Affiliation": "University of Strathclyde, UK."
},
{
"LastName": "Watson",
"FirstName": "Nicholas",
"Affiliation": "University of Glasgow, UK."
},
{
"LastName": "Mair",
"FirstName": "Frances S",
"Affiliation": "University of Glasgow, UK [email protected]."
}
] |
No
|
36425299
|
CD24 as a Potential Therapeutic Target in Patients with B-Cell Leukemia and Lymphoma: Current Insights.
|
CD24 is a highly glycosylated glycophosphatidylinositol (GPI)-anchored protein that is expressed in many types of differentiating cells and some mature cells of the immune system as well as the central nervous system. CD24 has been extensively used as a biomarker for developing B cells as its expression levels change over the course of B cell development. Functionally, engagement of CD24 induces apoptosis in developing B cells and restricts cell growth in more mature cell types. Interestingly, CD24 is also expressed on many hematological and solid tumors. As such, it has been investigated as a therapeutic target in many solid tumors including ovarian, colorectal, pancreatic, lung and others. Most of the B-cell leukemias and lymphomas studied to date express CD24 but its role as a therapeutic target in these malignancies has, thus far, been understudied. Here, I review what is known about CD24 biology with a focus on B cell development and activation followed by a brief overview of how CD24 is being targeted in solid tumors. This is followed by an assessment of the value of CD24 as a therapeutic target in B cell leukemia and lymphoma in humans, including an evaluation of the challenges in using CD24 as a target considering its pattern of expression on normal cells.
|
2022
|
OncoTargets and therapy
|
No DOI
|
[
{
"LastName": "Christian",
"FirstName": "Sherri L",
"Affiliation": "Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL, Canada."
}
] |
No
|
30199876
|
Patterns and Outcomes of the Top of the Basilar Artery Syndrome: The Role of the Posterior Communicating Artery.
|
Clinical syndromes secondary to infarcts in the distal basilar artery (BA) area have been described as "top of the basilar" (TOB) syndrome. However, in the era of advanced imaging technology, it has been realized that the clinical and imaging features are quite diverse in patients with distal BA occlusion. The aim of the present study was to investigate the patterns and clinical outcomes of TOB assessed with modern images and categorize TOBs accordingly. Additionally, we examined the possible influence of the posterior communicating artery (PcoA) on the patterns of TOB. Patients with distal BA occlusion on magnetic resonance angiography were categorized as TOB-A, and those with multiple lesions in the distal BA territory on diffusion-weighted magnetic resonance imaging as TOB-L. Patients with angiographically and lesion distribution-defined TOB were classified as having TOB-A&L; those with angiographically defined TOB as having TOB-A without TOB-L; and those with lesion distribution-defined TOB as having TOB-L without TOB-A. The PcoA was categorized as "textbook-type" (good P1) and "fetal-type" (absent P1). Factors associated with unfavorable short-term outcomes (modified Rankin Scale 5-6 at discharge), and 1-year and long-term mortalities, were assessed. Of 1,466 patients with ischemic stroke in the posterior circulation who were admitted to Asan Medical Center within 24 h of symptom onset, 124 (8.5%) had TOB, including 45 with TOB-A&L, 44 with TOB-A, and 35 with TOB-L. NIHSS scores (21 [9.5-26] vs. 6 [3-11.5] vs. 6 [3-9]; p < 0.01) and rates of motor deficit (75.6 vs. 54.5 vs. 34.4%; p < 0.01), concomitant pontine lesions (17.8 vs. 25.0 vs. 2.9%; p < 0.01), PcoA presence (44.4 vs. 68.2 vs. 25.7%; p < 0.01), and unfavorable short-term outcomes (62.2 vs. 25.0 vs. 14.3%; p < 0.01) differed significantly in the 3 patient groups. Multivariate analysis showed that textbook-type PcoA was independently associated with a lower frequency of unfavorable short-term outcomes (OR 0.15, 95% CI 0.03-0.70). Reperfusion therapy (hazard ratio [HR] 0.25, 95% CI 0.07-0.89) and the presence of textbook-type PcoA (HR 0.20, 95% CI 0.05-0.90) were associated with a lower 1-year mortality rate after stroke. Patterns and clinical outcomes of TOB vary and are affected by the hemodynamic status of the arterial system, such as BA recanalization and the presence of textbook-type PcoA.
|
2018
|
Cerebrovascular diseases (Basel, Switzerland)
|
No DOI
|
[
{
"LastName": "Ahn",
"FirstName": "Sung-Ho",
"Affiliation": "Department of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Busan, Republic of Korea."
},
{
"LastName": "Kim",
"FirstName": "Bum-Joon",
"Affiliation": "Department of Neurology, University of Ulsan, Asan Medical Center, Seoul, Republic of Korea."
},
{
"LastName": "Kim",
"FirstName": "Yeon-Jung",
"Affiliation": "Department of Neurology, University of Ulsan, Asan Medical Center, Seoul, Republic of Korea."
},
{
"LastName": "Kang",
"FirstName": "Dong-Wha",
"Affiliation": "Department of Neurology, University of Ulsan, Asan Medical Center, Seoul, Republic of Korea."
},
{
"LastName": "Kwon",
"FirstName": "Sun U",
"Affiliation": "Department of Neurology, University of Ulsan, Asan Medical Center, Seoul, Republic of Korea."
},
{
"LastName": "Kim",
"FirstName": "Jong S",
"Affiliation": "Department of Neurology, University of Ulsan, Asan Medical Center, Seoul, Republic of [email protected]."
}
] |
No
|
18968389
|
Determination of hardness in tapwater and upland soil extracts using a long-term stable divalent cation selective electrode based on a lipophilic acrylate resin as a membrane matrix.
|
A divalent cation-selective electrode, which utilizes a lipophilic resin as a matrix for the sensing membrane, and which has long-term stability has been developed. The sensing membrane is a lipophilic acrylate resin which is impregnated with a solution of 1-decylalcohol and the calcium salt of bis[4-(1,1,3,3-tetramethylbutyl) phenyl] phosphate at concentrations of 0.08 g ml(-1) each. The electrode exhibited nearly equal selectivity to Ca(2+) and Mg(2+) ions and could be used as a water hardness sensor. The electrode shows a Nernstian response with a slope of 29 mV decade(-1) to both Ca(2+) and Mg(2+) ions in the concentration range from 10(-5) M to 10(-1) M and could be used in the pH range from 3 to 10 for the determination of 10(-3) M Ca(2+) and Mg(2+) solutions. The initial performance of the electrode could be maintained for 1 year, since the lifetime test of the electrode was conducted in tapwater at a continuous flow rate of 4 ml min(-1). The hardnesses of tapwater and upland soil extracts were determined using the developed electrode and the analytical results were in good agreement with those obtained by chelatometric titration using an EDTA solution as the titrant. A coefficient factor of correlation 0.998 was obtained between the electrode method and titrimetry. The long-term stability of the electrode was found to be due to strong affinity of 1-decylalcohol to the lipophilic acrylate resin.
|
2001 Sep 13
|
Talanta
|
No DOI
|
[
{
"LastName": "Numata",
"FirstName": "M",
"Affiliation": "DKK Corporation, Kitamachi, Kichijoji, Musashino, Tokyo 100-0001, Japan."
},
{
"LastName": "Baba",
"FirstName": "K",
"Affiliation": ""
},
{
"LastName": "Hemmi",
"FirstName": "A",
"Affiliation": ""
},
{
"LastName": "Hachiya",
"FirstName": "H",
"Affiliation": ""
},
{
"LastName": "Ito",
"FirstName": "S",
"Affiliation": ""
},
{
"LastName": "Masadome",
"FirstName": "T",
"Affiliation": ""
},
{
"LastName": "Asano",
"FirstName": "Y",
"Affiliation": ""
},
{
"LastName": "Ohkubo",
"FirstName": "S",
"Affiliation": ""
},
{
"LastName": "Gomi",
"FirstName": "T",
"Affiliation": ""
},
{
"LastName": "Imato",
"FirstName": "T",
"Affiliation": ""
},
{
"LastName": "Hobo",
"FirstName": "T",
"Affiliation": ""
}
] |
No
|
38335655
|
Ameliorative effects of vanillin against pentylenetetrazole-induced epilepsy and associated memory loss in mice: The role of Nrf2/HO-1/NQO1 and HMGB1/RAGE/TLR4/NFκB pathways.
|
Epilepsy is a severe neurological disorder associated with substantial morbidity and mortality. Vanillin (Van) is a natural phenolic aldehyde with beneficial pharmacological properties. This study investigated the neuroprotective effects of Van in epilepsy and elucidated its mechanism of action. Swiss albino mice were divided into the following five groups: "normal group", 0.9 % saline; "pentylenetetrazole (PTZ) group", intraperitoneal administration of 35 mg/kg PTZ on alternate days up to 42 days; and "PTZ + Van 20", "PTZ + Van 40", and "PTZ + sodium valproate (Val)" groups received PTZ injections in conjunction withVan 20 mg, Van 40 mg/kg, and Val 300 mg/kg, respectively. Behavioural tests and hippocampal histopathological analysis were performed in all groups. The Nrf2/HO-1/NQO1 and HMGB1/RAGE/TLR4/NFκB pathways, oxidative stress, neuro-inflammation, and apoptotic markers were analysed. Furthermore, brain acetylcholinesterase (AChE) activity and levels of dopamine (DA), gamma-aminobutyric acid GABA, and serotonin 5-HT were assessed. Van prolonged seizure manifestations and improved electroencephalogram (EEG)criteriain conjunction with 100 mg/kg PTZ once daily. Van administration increased Nrf2/HO-1/NQO1 levels, with subsequent attenuation of malondialdehyde (MDA) and nitric oxide (NO) levels with elevated glutathione (GSH) levels and intensified superoxide dismutase (SOD) and catalase activities. Van reduced the gene and protein expression of HMGB1/RAGE/TLR4/NFκB and decreased the levels of inflammatory and apoptotic markers. In addition, Van reduced AChE activity, and elevated glial fibrillary acidic proteins (GFAP) increased neurotransmitter and brain-derived neurotrophic factors (BDNF). By increasing Nrf2/HO-1/NQO1 levels and downregulating the HMGB1/RAGE/TLR4/ NFκB pathway, Van offered protection in PTZ-kindled mice with subsequent attenuation in lipid peroxidation, upregulation in antioxidant enzyme activities, and reduction in inflammation and apoptosis.
|
2024 Mar 10
|
International immunopharmacology
|
No DOI
|
[
{
"LastName": "Almostafa",
"FirstName": "Mervt M",
"Affiliation": "Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia. Electronic address: [email protected]."
},
{
"LastName": "Mohamed",
"FirstName": "Maged E",
"Affiliation": "Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia; Department of Pharmacognosy, College of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: [email protected]."
},
{
"LastName": "Younis",
"FirstName": "Nancy S",
"Affiliation": "Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia; Zagazig University Hospitals, Zagazig University, Zagazig 44519, Egypt. Electronic address: [email protected]."
}
] |
No
|
35114771
|
Moderate congenital adrenal hyperplasia in two girls diagnosed by newborn screening.
|
Congenital adrenal hyperplasia (CAH) before the introducing a newborn screening was initially diagnosed based on clinical symptoms or positive family history and thereafter confirmed hormonal profiles. We present two female newborns with atypical screening results born shortly after the introduction of neonatal screening for congenital adrenal hyperplasia in the Wielkopolska region. Female patients 1 and 2 were both born at term and discharged from neonatal departments without any suspicion of disease. After performing complete neonatal screening for CAH, girls were admitted to the endocrine department for further investigations. In both cases, the girls did not exhibit characteristic symptoms of the disease. Using the Synacthen test, we observed an insufficient increase in cortisol and an abnormal increase in 17-OHP concentrations. The 24-hour urinary steroid profile analyzed by GC-MS confirmed the diagnosis. In both cases, treatment with hydrocortisone and fludrocortisone was initiated. Genetic evaluation confirmed mutations in the CYP21A2 gene. Newborn screening for CAH is useful for revealing a moderate form of CAH and indicates the need to start treatment in cases without typical signs of disease to prevent further virilization and the generation of a GnRH-independent precocious puberty. For nonobvious screening results, clinical information, including any data on virilization, is extremely helpful. Therefore, a careful assessment of newborns' genitalia in neonatal departments is important. The screening laboratory should be informed about any abnormalities to perform a complete screening immediately decreasing significantly the time between taking the paper sample and the final diagnosis.
|
2021
|
Pediatric endocrinology, diabetes, and metabolism
|
No DOI
|
[
{
"LastName": "Banaszak-Ziemska",
"FirstName": "Magdalena",
"Affiliation": "Karol Jonscher's Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland."
},
{
"LastName": "Małecka",
"FirstName": "Elżbieta",
"Affiliation": "Karol Jonscher's Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland."
},
{
"LastName": "Łacna",
"FirstName": "Katarzyna",
"Affiliation": "Center of Medical Genetics GENESIS, Poznan, Poland."
},
{
"LastName": "Ginalska-Malinowska",
"FirstName": "Maria",
"Affiliation": "Screening and Metabolic Diseases Department, Institute of Mother and Child, Warsaw, Poland."
},
{
"LastName": "Niedziela",
"FirstName": "Marek",
"Affiliation": "Karol Jonscher's Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland."
}
] |
No
|
34646419
|
Primary pure large cell neuroendocrine carcinoma of the ovary: histopathologic and immunohistochemical analysis with review of the literature.
|
Primary ovarian large cell neuroendocrine carcinoma (POLNEC) is an extremely rare and highly aggressive malignancy. Establishing a definite diagnosis requires histopathologic examination with immunohistochemical demonstration of neuroendocrine differentiation in the tumor cells. The histopathology may overlap with a variety of other ovarian malignancies; however, rendering an accurate diagnosis is essential, owing to the therapeutic and prognostic implications. A 62-year-old, post-menopausal woman presented with complaints of abdominal fullness and dull-aching abdominal pain for the last three months. A pelvic ultrasound revealed the presence of a complex adnexal mass. Serum levels of tumor markers, CA125, carcinoembryonic antigen, alpha-fetoprotein, and beta-human chorionic gonadotropin, were within normal limits. Pelvic magnetic resonance imaging showed a heterogeneous lobulated right adnexal mass measuring 6.7×5.8×5.6 cm, which was T2-hyperintense and T1-hypointense. A provisional diagnosis of ovarian carcinoma was made, and a total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Histopathology showed an organoid and nesting pattern with a focal perivascular arrangement of the tumor cells with large, moderately pleomorphic, round to oval nuclei, granular chromatin, conspicuous nucleoli, and a moderate amount of pale-eosinophilic cytoplasm. Brisk mitosis and lymphovascular space involvement were noted. On immunohistochemistry, the tumor cells showed positivity for chromogranin, synaptophysin, and neuron-specific enolase and were negative for PAX8, WT1, vimentin, and epithelial membrane antigen. p53 showed wild-type, and SMARCB1/INI-1 showed retained nuclear expression. Based on the histopathologic and immunohistochemical features, a final diagnosis of POLNEC was rendered. The patient received 4 cycles of adjuvant chemotherapy and is disease-free, 28 months post-treatment. The present report highlights the characteristic histopathologic and immunohistochemical features of POLCNEC to distinguish it from other clinicopathologic mimics and present a comprehensive review of the published literature of all such cases.
|
2021
|
International journal of clinical and experimental pathology
|
No DOI
|
[
{
"LastName": "Gupta",
"FirstName": "Parikshaa",
"Affiliation": "Department of Cytology and Gynecologic Pathology, Post Graduate Institute of Medical Education and Research Chandigarh, India."
},
{
"LastName": "Bagga",
"FirstName": "Rashmi",
"Affiliation": "Department of Obstetrics and Gynecology, Post Graduate Institute of Medical Education and Research Chandigarh, India."
},
{
"LastName": "Rai",
"FirstName": "Bhavana",
"Affiliation": "Department of Radiotherapy, Post Graduate Institute of Medical Education and Research Chandigarh, India."
},
{
"LastName": "Srinivasan",
"FirstName": "Radhika",
"Affiliation": "Department of Cytology and Gynecologic Pathology, Post Graduate Institute of Medical Education and Research Chandigarh, India."
}
] |
No
|
36435904
|
New Luminescent Pyridine-based Disc type Molecules: Synthesis, Photophysical, Electrochemical, and DFT studies.
|
The design and synthesis of new conjugated luminescent molecules have attracted the attention of researchers because of their various applications, especially in the field of optoelectronic devices. Most of the applications were mainly based on the intramolecular charge transfer (ICT). For this purpose, we designed and synthesized a series of new donor-acceptor based disc type molecules i.e. 2,4,6-tris(4-(alkyloxy)phenyl)pyridines carrying variable alkoxy chains [i.e. n = 2, 4, 6, 8, 10, 12, 14, 16]. Further, the structures of all the synthesized compounds were confirmed by using ATR-IR, [1]H-NMR, [13]C-NMR, and ESI-MS analysis. Moreover, the photophysical property study indicated that all the molecules are blue light emitting materials, however the change of alkoxy chain length in phenyl arms does not affect their absorption, emission, and energy levels. Besides, the thermal study revealed that core is stable up to 350 °C. Also, the DFT study showed that the photo induced electron transfer caused by HOMO-LUMO excitation in the studied molecules. Therefore, all the molecules have potential applications in optoelectronic applications.
|
2023 Mar
|
Journal of fluorescence
|
No DOI
|
[
{
"LastName": "Devadiga",
"FirstName": "Deepak",
"Affiliation": "Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bangalore, 562112, India."
},
{
"LastName": "Ahipa",
"FirstName": "T N",
"Affiliation": "Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bangalore, 562112, India. [email protected]."
},
{
"LastName": "Bhat",
"FirstName": "S Vanishree",
"Affiliation": "Raman Research Institute, Soft Condensed Matter Group, C. V. Raman Avenue, Bangalore, 560080, India."
},
{
"LastName": "Kumar",
"FirstName": "Sandeep",
"Affiliation": "Raman Research Institute, Soft Condensed Matter Group, C. V. Raman Avenue, Bangalore, 560080, India."
}
] |
No
|
33537825
|
The role of the Golgi apparatus in disease (Review).
|
The Golgi apparatus is known to underpin many important cellular homeostatic functions, including trafficking, sorting and modifications of proteins or lipids. These functions are dysregulated in neurodegenerative diseases, cancer, infectious diseases and cardiovascular diseases, and the number of disease‑related genes associated with Golgi apparatus is on the increase. Recently, many studies have suggested that the mutations in the genes encoding Golgi resident proteins can trigger the occurrence of diseases. By summarizing the pathogenesis of these genetic diseases, it was found that most of these diseases have defects in membrane trafficking. Such defects typically result in mislocalization of proteins, impaired glycosylation of proteins, and the accumulation of undegraded proteins. In the present review, we aim to understand the patterns of mutations in the genes encoding Golgi resident proteins and decipher the interplay between Golgi resident proteins and membrane trafficking pathway in cells. Furthermore, the detection of Golgi resident protein in human serum samples has the potential to be used as a diagnostic tool for diseases, and its central role in membrane trafficking pathways provides possible targets for disease therapy. Thus, we also introduced the clinical value of Golgi apparatus in the present review.
|
2021 Apr
|
International journal of molecular medicine
|
No DOI
|
[
{
"LastName": "Liu",
"FirstName": "Jianyang",
"Affiliation": "Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China."
},
{
"LastName": "Huang",
"FirstName": "Yan",
"Affiliation": "Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China."
},
{
"LastName": "Li",
"FirstName": "Ting",
"Affiliation": "Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China."
},
{
"LastName": "Jiang",
"FirstName": "Zheng",
"Affiliation": "Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China."
},
{
"LastName": "Zeng",
"FirstName": "Liuwang",
"Affiliation": "Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China."
},
{
"LastName": "Hu",
"FirstName": "Zhiping",
"Affiliation": "Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China."
}
] |
No
|
28639891
|
Antitumor activity of a Rhodococcus sp. Lut0910 isolated from polluted soil.
|
The actinomycetes strain, lut0910, was isolated from polluted soil and identified as the Rhodococcus species with 99% similarity based on the sequence analysis of 16S recombinant DNA. The extract of this strain demonstrated in vivo and in vitro antitumor activity. The treatment of two human cancer cell lines, hepatocellular carcinoma HepG2 and cervical carcinoma Hela cells, with the lut0910 extract caused the delay in cell propagation in a dose-dependent manner with an IC50 of 73.39 and 33.09 µg/mL, respectively. Also, the oral administration of lut0910 extract to the mice with a solid tumor resulted in the inhibition of tumor growth in comparison with a placebo group. The thymus and spleen indexes were significantly increased in mice groups treated with the lut0910 extract. The histopathological changes of the tumor tissues showed that there were massive necrotic areas in the tumor tissues after treatment with different doses of the lut0910 extract. Our result would provide a new way and potent source for development of new anticancer agent from the polluted environment.
|
2017 Jun
|
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
|
No DOI
|
[
{
"LastName": "Zhang",
"FirstName": "Xin-Guo",
"Affiliation": "1 School of Life Science and Engineering, Lanzhou University of Technology, Gansu, P.R. China."
},
{
"LastName": "Liu",
"FirstName": "Zi-Yu",
"Affiliation": "1 School of Life Science and Engineering, Lanzhou University of Technology, Gansu, P.R. China."
},
{
"LastName": "Liu",
"FirstName": "Jin-Wen",
"Affiliation": "1 School of Life Science and Engineering, Lanzhou University of Technology, Gansu, P.R. China."
},
{
"LastName": "Zeng",
"FirstName": "Yan-Long",
"Affiliation": "1 School of Life Science and Engineering, Lanzhou University of Technology, Gansu, P.R. China."
},
{
"LastName": "Guo",
"FirstName": "Guang-Jun",
"Affiliation": "1 School of Life Science and Engineering, Lanzhou University of Technology, Gansu, P.R. China."
},
{
"LastName": "Sun",
"FirstName": "Qiao-Yun",
"Affiliation": "1 School of Life Science and Engineering, Lanzhou University of Technology, Gansu, P.R. China."
}
] |
No
|
33097069
|
Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection.
|
Gastric adenocarcinoma of the fundic gland type (GA-FG) has been added to the 2019 edition of the World Health Organization's list of digestive system-associated cancers. This lesion differentiates toward the fundic gland and mostly involves chief cell-predominant differentiation with low-grade cytology. Clinicians and pathologists are still unaware of this rare disease; consequently, some cases are incorrectly diagnosed. This study aimed to investigate the clinicopathological features of GA-FG using retrospective analyses of endoscopic and pathological findings. Samples were collected from patients diagnosed with GA-FG. The clinical courses of all patients were monitored prospectively and reviewed retrospectively. Available clinical information, endoscopic features, pathological appearance, and follow-up data were assessed. Immunohistochemistry [mucin (MUC) 2, MUC5, MUC6, P53, CDX2, Ki67, SYN, CD56, CGA, β-catenin, and pepsinogen-I] was examined using Envision two-step method. Eight cases of endoscopic submucosal dissection (ESD) were obtained from our institution. Patient age ranged from 48 to 80 years (mean, 65 years). Some patients were on acid-suppressing medication. Most lesions were located in the upper third (n = 7) and one was in the middle third of the stomach. Six lesions were of the superficial flat type, whereas two were of the superficial elevated type. Narrow-band imaging using magnifying endoscopy showed irregular microvascular patterns (MVPs) in four cases and regular MVPs in the remaining cases. All lesions were primarily solitary and ~ 6 mm in diameter (largest, 12 mm). The main body of the tumors were localized in the mucosal layer, of which six cases invade into the submucosal layer. Well-formed glands of chief cells were predominant. Tumor cells were positive for pepsinogen-I, MUC6, SYN, and CD56. Lymphatic and vascular infiltration and metastatic and recurrent disease were not observed in any case. GA-FG, a well-differentiated adenocarcinoma with mild atypia, can be completely removed using ESD, with a favorable prognosis in patients.
|
2020 Oct 23
|
Diagnostic pathology
|
No DOI
|
[
{
"LastName": "Li",
"FirstName": "Chengfang",
"Affiliation": "Department of Pathology, Affiliated Hospital of Zunyi Medical University, Guizhou, 563003, China."
},
{
"LastName": "Wu",
"FirstName": "Xinglong",
"Affiliation": "Department of Pathology, Affiliated Hospital of Zunyi Medical University, Guizhou, 563003, China."
},
{
"LastName": "Yang",
"FirstName": "Shuang",
"Affiliation": "Department of Pathology, Affiliated Hospital of Zunyi Medical University, Guizhou, 563003, China."
},
{
"LastName": "Yang",
"FirstName": "Xiaorong",
"Affiliation": "Department of Pathology, Affiliated Hospital of Zunyi Medical University, Guizhou, 563003, China."
},
{
"LastName": "Yao",
"FirstName": "Jin",
"Affiliation": "Department of Pathology, Affiliated Hospital of Zunyi Medical University, Guizhou, 563003, China."
},
{
"LastName": "Zheng",
"FirstName": "Hong",
"Affiliation": "Department of Pathology, Affiliated Hospital of Zunyi Medical University, Guizhou, 563003, China. [email protected]."
}
] |
No
|
35126662
|
EST-SSR Marker Development and Full-Length Transcriptome Sequence Analysis of Tiger Lily (Lilium lancifolium Thunb).
|
The fast advancement and deployment of sequencing technologies after the Human Genome Project have greatly increased our knowledge of the eukaryotic genome sequences. However, due to technological concerns, high-quality genomic data has been confined to a few key organisms. Moreover, our understanding of which portions of genomes make up genes and which transcript isoforms synthesize these genes is scarce. Therefore, the current study has been designed to explore the reliability of the tiger lily (Lilium lancifolium Thunb) transcriptome. The PacBio-SMRT was used for attaining the complete transcriptomic profile. We obtained a total of 815,624 CCS (Circular Consensus Sequence) reads with an average length of 1295 bp. The tiger lily transcriptome has been sequenced for the first time using third-generation long-read technology. Furthermore, unigenes (38,707), lncRNAs (6852), and TF members (768) were determined based on the transcriptome data, followed by evaluating SSRs (3319). It has also been revealed that 105 out of 128 primer pairs effectively amplified PCR products. Around 15,608 transcripts were allocated to 25 distinct KOG Clusters, and 10,706 unigenes were grouped into 52 functional categories in the annotated transcripts. Until now, no tiger lily lncRNAs have been discovered. Results of this study may serve as an extensive set of reference transcripts and help us learn more about the transcriptomes of tiger lilies and pave the path for further research.
|
2022
|
Applied bionics and biomechanics
|
No DOI
|
[
{
"LastName": "Sun",
"FirstName": "Mingwei",
"Affiliation": "Lianyungang Academy of Agricultural Sciences, Lianyungang, China."
},
{
"LastName": "Zhao",
"FirstName": "Yilian",
"Affiliation": "Nanjing Forest University, Nanjing, China."
},
{
"LastName": "Shao",
"FirstName": "Xiaobin",
"Affiliation": "Lianyungang Academy of Agricultural Sciences, Lianyungang, China."
},
{
"LastName": "Ge",
"FirstName": "Jintao",
"Affiliation": "Lianyungang Academy of Agricultural Sciences, Lianyungang, China."
},
{
"LastName": "Tang",
"FirstName": "Xueyan",
"Affiliation": "Lianyungang Academy of Agricultural Sciences, Lianyungang, China."
},
{
"LastName": "Zhu",
"FirstName": "Pengbo",
"Affiliation": "Lianyungang Academy of Agricultural Sciences, Lianyungang, China."
},
{
"LastName": "Wang",
"FirstName": "Jiangying",
"Affiliation": "Lianyungang Academy of Agricultural Sciences, Lianyungang, China."
},
{
"LastName": "Zhao",
"FirstName": "Tongli",
"Affiliation": "Lianyungang Academy of Agricultural Sciences, Lianyungang, China."
}
] |
Yes
|
31929827
|
Analysis of Spiders' Joint Kinematics and Driving Modes under Different Ground Conditions.
|
Although the hydraulic transmission system in spider legs is well known, the spider's mechanism of locomotion during different terrain conditions still need to be explored further. In this study, spider locomotion was observed in detail on three pavement test platforms: horizontal hard pavement, horizontal soft pavement, and sloped soft pavement. The movement characteristics and joint kinematics of Grammostola rosea legs were captured by high-speed cameras and Simi Motion 3D tracking software. These observations showed that the gait pattern was basically consistent with an alternating tetrapod gait; however, the pattern observed on the sloped soft pavement was slightly different from that of the two horizontal pavements. In particular, the duty factor of the spiders was 0.683 when walking on the horizontal hard pavement, 0.668 on the horizontal soft pavement, and 0.630 on the sloped soft pavement. The duty factor was greater than 60% in all three pavement environments, which was minimal when walking on the sloped soft pavement. This pattern showed that spiders might have superior stability when walking, but their stability decreased in the sloped soft pavement environment. The ranges of joint angles through the spiders' gait cycles in every pavement environment were also analysed and compared. The findings showed that the hydraulically driven femur-patella and tibia-metatarsal joint angles varied widely, which confirmed that hydraulically driven joints had major functions and obvious effects on the walking process. The kinematic patterns identified in this study provide improved understanding of the hydraulic transmission mechanisms, the factors that affect motion stability, and the design of biomimetic systems.
|
2019
|
Applied bionics and biomechanics
|
No DOI
|
[
{
"LastName": "Hao",
"FirstName": "Xin",
"Affiliation": "School of Mechanical and Aerospace Engineering, Jilin University, Changchun 130022, China."
},
{
"LastName": "Ma",
"FirstName": "Wenxing",
"Affiliation": "School of Mechanical and Aerospace Engineering, Jilin University, Changchun 130022, China."
},
{
"LastName": "Liu",
"FirstName": "Chunbao",
"Affiliation": "School of Mechanical and Aerospace Engineering, Jilin University, Changchun 130022, China."
},
{
"LastName": "Li",
"FirstName": "Yilei",
"Affiliation": "Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun 130022, China."
},
{
"LastName": "Qian",
"FirstName": "Zhihui",
"Affiliation": "Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun 130022, China."
},
{
"LastName": "Ren",
"FirstName": "Luquan",
"Affiliation": "Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun 130022, China."
},
{
"LastName": "Ren",
"FirstName": "Lei",
"Affiliation": "Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun 130022, China."
}
] |
No
|
21255330
|
Ribose utilization by the human commensal Bifidobacterium breve UCC2003.
|
Growth of Bifidobacterium breve UCC2003 on ribose leads to the transcriptional induction of the rbsACBDK gene cluster. Generation and phenotypic analysis of an rbsA insertion mutant established that the rbs gene cluster is essential for ribose utilization, and that its transcription is likely regulated by a LacI-type regulator encoded by rbsR, located immediately upstream of rbsA. Gel mobility shift assays using purified RbsR(His) indicate that the promoter upstream of rbsABCDK is negatively controlled by RbsR(His) binding to an 18 bp inverted repeat and that RbsR(His) binding activity is modulated by D-ribose. The rbsK gene of the rbs operon of B. breve UCC2003 was shown to specify a ribokinase (EC 2.7.1.15), which specifically directs its phosphorylating activity towards D-ribose, converting this pentose sugar to ribose-5-phosphate.
|
2010 May
|
Microbial biotechnology
|
No DOI
|
[
{
"LastName": "Pokusaeva",
"FirstName": "Karina",
"Affiliation": "Alimentary Pharmabiotic Centre, Department of Microbiology, University College Cork, Western Road, Cork, Ireland."
},
{
"LastName": "Neves",
"FirstName": "Ana Rute",
"Affiliation": ""
},
{
"LastName": "Zomer",
"FirstName": "Aldert",
"Affiliation": ""
},
{
"LastName": "O'Connell-Motherway",
"FirstName": "Mary",
"Affiliation": ""
},
{
"LastName": "MacSharry",
"FirstName": "John",
"Affiliation": ""
},
{
"LastName": "Curley",
"FirstName": "Peter",
"Affiliation": ""
},
{
"LastName": "Fitzgerald",
"FirstName": "Gerald F",
"Affiliation": ""
},
{
"LastName": "van Sinderen",
"FirstName": "Douwe",
"Affiliation": ""
}
] |
No
|
30381833
|
Alcohol Use Among Never-Deployed U.S. Army Reserve and National Guard Soldiers: The Effects of Nondeployment Emotions and Sex.
|
Limited research shows that mental health problems are prevalent among never-deployed soldiers and many experience negative emotions related to their nondeployment. U.S. Army Reserve/National Guard (USAR/NG) soldiers are also at high risk for alcohol misuse. However, it is not known if nondeployment emotions contribute to an increased risk of alcohol misuse among never-deployed USAR/NG soldiers. Data are from Operation: SAFETY (Soldiers and Families Excelling Through the Years), an ongoing study of USAR/NG soldiers. We used regression models to examine the relations between nondeployment emotions, assessed by the Non-Deployment Emotions (NDE) Questionnaire, and a range of alcohol use outcomes, assessed by the Alcohol Use Disorders Identification Test and standard quantity and frequency questions, among a sample of never-deployed soldiers who were partnered at baseline (N = 174). Final models controlled for years of military service, current number of close military friends in the social network, marital satisfaction, and depression. We also tested for potential differences in these associations by sex. Nondeployment emotions were associated with frequency of getting drunk (adjusted risk ratio [aRR] = 1.02, 95% CI: 1.01, 1.04; p < 0.05) and typical number of drinks consumed during a drinking episode (aRR = 1.03, 95% CI: 1.01, 1.04; p < 0.01). Nondeployment emotions had a trend-level association with percent of days drinking (adjusted odds ratio = 1.05, 95% CI: 1.00, 1.11; p = 0.055). Nondeployment emotions had a significant interaction with sex (p < 0.05) on the likelihood of alcohol problems, such that only male soldiers experienced a greater likelihood of alcohol problems when they had highly negative nondeployment emotions. There was no relation between nondeployment emotions and alcohol problems among female soldiers. Findings demonstrate that greater nondeployment emotions are associated with increased alcohol use among never-deployed USAR/NG soldiers. The NDE Questionnaire may assist in identifying those at highest risk for alcohol problems.
|
2018 Dec
|
Alcoholism, clinical and experimental research
|
No DOI
|
[
{
"LastName": "Hoopsick",
"FirstName": "Rachel A",
"Affiliation": "Department of Community Health and Health Behavior , School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, New York."
},
{
"LastName": "Homish",
"FirstName": "D Lynn",
"Affiliation": "Department of Community Health and Health Behavior , School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, New York."
},
{
"LastName": "Vest",
"FirstName": "Bonnie M",
"Affiliation": "Department of Family Medicine , Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, New York."
},
{
"LastName": "Homish",
"FirstName": "Gregory G",
"Affiliation": "Department of Community Health and Health Behavior , School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, New York."
}
] |
No
|
17642569
|
A study of rheumatological manifestations of leprosy.
|
Rheumatic manifestations are a common feature of leprosy. The present study was performed to assess the incidence of rheumatic manifestations in leprosy. Seventy cases of leprosy attending the indoor and outdoor departments were studied. Out of the 70 cases studied, rheumatic manifestations were seen in 61.42% of cases: arthritis in 54.28% and soft tissue rheumatism in 17.14%. Enthesitis was seen in 2.84% of cases. The incidence of arthritis in lepra reactions was 57.57%. Musculoskeletal manifestations can occur at any time during the infection. Articular inflammation in leprosy usually occurs in reactive states, particularly erythema nodosum leprosum (ENL). Leprosy can present with arthritis as the first symptom.
|
2004 Mar-Apr
|
Indian journal of dermatology, venereology and leprology
|
No DOI
|
[
{
"LastName": "Vengadakrishnan",
"FirstName": "K",
"Affiliation": "Department of Medicine, G. R. Medical College and J. A. Group of Hospitals, Gwalior."
},
{
"LastName": "Saraswat",
"FirstName": "P K",
"Affiliation": ""
},
{
"LastName": "Mathur",
"FirstName": "P C",
"Affiliation": ""
}
] |
No
|
38628661
|
A prospective analysis of the efficacy of phase II autologous skin grafting on deep second‑degree burns on the dorsum of the hand.
|
The aim of the present study was to investigate the possibility of reducing the damage to the donor site while preserving the functional recovery of the dorsum of the hand following burn injury. An attempt was made to analyze the effect of a phased surgery approach on inflammatory indicators. A two-phase treatment was administered on a total of 64 patients with deep second-degree burns on the dorsum of the hand who were admitted to Guangzhou Red Cross Hospital between January 2020 and March 2023. During phase I treatment, the wounds were covered with xenogeneic (porcine) skin, followed by the application of autologous thin intermediate thickness skin grafts for wound repair in phase II treatment 1 week later. The surgical results, complications, patient satisfaction and inflammatory response indicators were then analyzed. The mean wound healing time of these patients was found to be 21.94 days without complications. The mean survival rate was 98.66%, and the overall satisfaction score of the patients was high. Finally, the white blood cell, C-reactive protein and IL-6 levels of these patients were continuously decreased 2 days preoperatively and 2 days postoperatively in phase I, and 2 days preoperatively and 2 days postoperatively in phase II. In combination, the effect of phased autologous skin grafting in patients with severe second-degree burns on the dorsum of the hand was ideal, as it significantly reduced inflammatory response and was beneficial to the functional recovery of the hand. Therefore, phased autologous skin grafting is worthy of wider application.
|
2024 May
|
Experimental and therapeutic medicine
|
No DOI
|
[
{
"LastName": "Sun",
"FirstName": "Jing'en",
"Affiliation": "Department of Burns and Plastic Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong 510220, P.R. China."
},
{
"LastName": "Su",
"FirstName": "Siman",
"Affiliation": "Department of Pharmacology, Shantou University Medical College, Shantou, Guangdong 515041, P.R. China."
},
{
"LastName": "Jiao",
"FirstName": "Songsong",
"Affiliation": "Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong 510220, P.R. China."
},
{
"LastName": "Li",
"FirstName": "Gang",
"Affiliation": "Department of Burns and Plastic Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong 510220, P.R. China."
},
{
"LastName": "Zhang",
"FirstName": "Zhi",
"Affiliation": "Department of Burns and Plastic Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong 510220, P.R. China."
},
{
"LastName": "Lin",
"FirstName": "Weihua",
"Affiliation": "Department of Burns and Plastic Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong 510220, P.R. China."
},
{
"LastName": "Zhang",
"FirstName": "Shuyao",
"Affiliation": "Department of Pharmacy, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong 510220, P.R. China."
}
] |
No
|
18340138
|
Implementing clinical pathways for patients admitted to a medical service: lessons learned.
|
In an attempt to improve quality of care for patients admitted to our medical service we have implemented the use of pathways. These are printed standards of care and a mechanism for daily multidisciplinary documentation. The goals of our pathways are to: improve quality using printed standards of care; improve documentation of the care delivered; improve communication about daily goals between all team members, patients and families; standardize our in-patient chart format throughout the hospital; and increase efficiency of care. Pathways were designed to provide physicians and nurses with the standards for care and provide a mechanism for multidisciplinary documentation on our in-patient charts. We now have 2 pathways in use on our medical service. One is a clinical care plan (CCP) and the other is a Pancreatitis Pathway (PP) for patients admitted with acute pancreatitis and the other a guideline for care for all patients. The pathways were developed by teams including attending physicians (General Internists and Gastroenterologists), medicine house officers, nurses, and care coordinators. The pathways are used for all patients admitted to our medical service if they are admitted to one of 2 floors. This paper includes a comparison of outcomes for our first 9 patients who were managed using the pancreatitis pathway versus 7 patients cared for without the pathway. Significant differences in the pancreatitis pathway treated patients included: 1) less intense pain on day 2, (P = 0.04); 2) less pain on day of refeeding (P = 0.004); and 3) less IV fluids administered (P = 0.05). We also describe several lessons we have learned about using pathways for in-patients on a medical service in an academic medical center. We have learned the following lessons. Nursing documentation is improved. Physicians need ongoing encouragement and education about the value of pathways. There is considerable work involved for unit coordinators, care coordinators, and nursing in using pathways on a medical-surgical floor. There must be physician and nurse champions. There must be ongoing feedback to users. There must be input from users and edits. We believe the use of pathways as a process to remind clinicians of quality standards will improve the care of our patients by decreasing variation, improving team communication, and enhancing patient and family education.
|
2004 Mar
|
Critical pathways in cardiology
|
No DOI
|
[
{
"LastName": "Goldszer",
"FirstName": "Robert C",
"Affiliation": "Brigham and Women's Hospital, Boston, MA 02115, USA. [email protected]"
},
{
"LastName": "Rutherford",
"FirstName": "Anna",
"Affiliation": ""
},
{
"LastName": "Banks",
"FirstName": "Peter",
"Affiliation": ""
},
{
"LastName": "Zou",
"FirstName": "Kelly H",
"Affiliation": ""
},
{
"LastName": "Curley",
"FirstName": "Maureen",
"Affiliation": ""
},
{
"LastName": "Rossi",
"FirstName": "Patricia Brita",
"Affiliation": ""
},
{
"LastName": "Kahlert",
"FirstName": "Terry",
"Affiliation": ""
},
{
"LastName": "Goulart",
"FirstName": "Dorothy",
"Affiliation": ""
},
{
"LastName": "Santos",
"FirstName": "Katherine",
"Affiliation": ""
},
{
"LastName": "Gustafson",
"FirstName": "Michael",
"Affiliation": ""
}
] |
No
|
37064947
|
Hydroethanolic Leaf Extract of Cordia vignei Hutch and Dalziel Inhibits Carrageenan-Induced Foot Oedema in Chicks, Prostaglandin E(2)-Induced Paw Oedema in Mice, and Bradykinin-Induced Paw Oedema in Mice.
|
Cordia vignei Hutch and Dalziel (Fam. Boraginaceae) is a woody plant found in west tropical Africa. The aim of this research is to find out if the leaf extract of this plant prevents oedema in animal models. (a) Inflammation was induced in the animals by injecting 100 µl of 2% lambda carrageenan into the subplantar tissue of the right footpads of 7-day-old chicks 1 h before or after oral administration of 30-300 mgkg[-1] CVE. Oedema was measured for 5 h using the water displacement method. (b) Oedema was induced in ICR mice by subplantar injection of prostaglandin E2 (PGE2) (50 µl of 1 nM) 30 minutes before or after CVE administration. Oedema was measured for 3 h. (c) Oedema was induced in ICR mice by subplantar injection of bradykinin (BK) (10 nmol/paw) 30 min before or after administration of extract. We found that CVE significantly (P < 0.05) prevented inflammation that was induced by injecting carrageenan into the footpads of the chicks. Also, we observed that CVE prevented inflammation produced by injecting PGE2 into the subplantar tissue of mice. Finally, we also report that CVE prevented inflammation produced by injecting BK into the subplantar tissues of mice. All these effects were observed in both preventive and curative protocols. We conclude that Cordia vignei leaf extract has potential anti-inflammatory activity.
|
2023
|
Evidence-based complementary and alternative medicine : eCAM
|
No DOI
|
[
{
"LastName": "Owusu",
"FirstName": "George",
"Affiliation": "Deparment of Medical Laboratory Science, University of Energy and Natural Resources, Sunyani, Ghana."
},
{
"LastName": "Ainooson",
"FirstName": "George K",
"Affiliation": "Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana."
},
{
"LastName": "Osafo",
"FirstName": "Newman",
"Affiliation": "Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana."
}
] |
No
|
39042260
|
Molecular analyses of MEFV gene mutation variants in Turkish population.
|
Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disease primarily affecting individuals of Turkish, Armenian, Arab, and non-Ashkenazi Jewish descent, caused by mutations in the MEFV gene. The aim of this study was to review the common genotype distributions of MEFV variants and mutations in the Turkish population and evaluate rare mutations. The study included 2984 patients who applied to Ankara University Ibni Sina Hospital Immunology Laboratory with clinical suspicion of FMF between 2004 and 2014. The data of patients from different regions of the country who were followed up in the immunology-rheumatology clinic with clinical suspicion and presumptive diagnosis of FMF were evaluated retrospectively. Patients were tested for all mutations in Exon 2 and Exon 10, including M694V, M680I, M694I, V726A, E148Q and R202Q. There were 2504 patients with FMF variant. According to genotyping, R202Q (n = 1567, 39.2%) was the most common mutation. The most common co-variant was the R202Q/M694V genotype (n = 507, 16.98%). Allele frequencies for MEFV mutations were as follows: R202Q (n = 1567, 39.2%), M694V (n = 1004, 25.1%), E148Q (n = 463, 11.5%), M680I (n = 354, 8.8%), V726A (n = 319, 7.9%), A744S (n = 51, 1.2%), R761H (N = 41, 1.0%), P706P (N = 25, 0.6%), E167D (N = 23, 0.5%), M694I (N = 23, 0.5%), and K695R (N = 20, 0.5%). This research revealed the prevalence of both common and rare MEFV gene mutations in Turkish FMF patients in various age groups. R202Q was the most prevalent mutation.
|
2024 Jul 23
|
Molecular biology reports
|
No DOI
|
[
{
"LastName": "Aksoy",
"FirstName": "Rahime",
"Affiliation": "Department of Hematology, Faculty of Medicine, Ankara University, Ankara, Türkiye. [email protected]."
},
{
"LastName": "Us",
"FirstName": "Ebru",
"Affiliation": "Department of Medical Microbiology, Faculty of Medicine, Ankara University, Ankara, Türkiye."
},
{
"LastName": "Aksoy",
"FirstName": "Darya Farhoomand",
"Affiliation": "Department of Biology, Faculty of Science, Ankara University, Ankara, Türkiye."
},
{
"LastName": "Dumlupınar",
"FirstName": "Ebru",
"Affiliation": "Department of Biostatistics, Faculty of Medicine, Ankara University, Ankara, Türkiye."
},
{
"LastName": "Turgay",
"FirstName": "Tahsin Murat",
"Affiliation": "Department of Rheumatology, Faculty of Medicine, Ankara University, Ankara, Türkiye."
}
] |
No
|
16352089
|
Blalock-Taussig shunt: experience from the developing world.
|
Palliative procedures have a role in congenital cardiac malformations that do not permit a complete early repair, and in centres where facilities for complete early repair do not exist. The lack of data on modified Blalock-Taussig shunt from developing countries prompted this analysis. We report a retrospective study of 70 Blalock-Taussig shunt procedures in 63 patients over an 8-year period. Most of the procedures (54.0%) were done on children less than 4 months of age. Thirty-nine (58%) patients had Tetralogy of Fallot; the remaining patients had a wide spectrum of lesions. In the first year of the review period, the classical Blalock-Taussig shunt was done in six patients (9.5%) and the modified Blalock-Taussig shunt was used thereafter. In 49 patients who were followed up long term, clinical congestive cardiac failure developed in three (6%) and shunt failure was reported in 10 (14%). Of the 16 (33%) total deaths, six had serious comorbid conditions preoperatively. The Blalock-Taussig shunt is a relatively safe palliative procedure, requiring fewer resources and less expertise than corrective surgery, making it a suitable option in developing countries.
|
2002
|
Heart, lung & circulation
|
No DOI
|
[
{
"LastName": "Rana",
"FirstName": "Jamal S",
"Affiliation": "School of Medicine, The Aga Khan University, Karachi, Pakistan. [email protected]"
},
{
"LastName": "Ahmad",
"FirstName": "Kaashif A",
"Affiliation": ""
},
{
"LastName": "Shamim",
"FirstName": "Aliya S",
"Affiliation": ""
},
{
"LastName": "Hassan",
"FirstName": "Sulaiman B",
"Affiliation": ""
},
{
"LastName": "Ahmed",
"FirstName": "Mehnaz A",
"Affiliation": ""
}
] |
No
|
39024301
|
Correction: Acceptance and hesitancy of parents to vaccinate children against coronavirus disease 2019 in Saudi Arabia.
|
[This corrects the article DOI: 10.1371/journal.pone.0276183.].
|
2024
|
PloS one
|
No DOI
|
[
{
"LastName": "Mansour",
"FirstName": "Ahd A",
"Affiliation": ""
},
{
"LastName": "Hussein",
"FirstName": "Sarah M",
"Affiliation": ""
},
{
"LastName": "Felemban",
"FirstName": "Shatha G",
"Affiliation": ""
},
{
"LastName": "Mahamid",
"FirstName": "Adib W",
"Affiliation": ""
}
] |
No
|
37731370
|
Ivy leaf dry extract EA 575 for the treatment of acute and chronic cough in pediatric patients: review and expert survey.
|
EA 575 (Prospan) is a herbal medicine containing a dried extract of ivy leaves (drug extract ratio 5-7.5:1; extraction solvent, 30% ethanol). Although widely used for the treatment of cough, there remains a lack of clarity on the effects of EA 575 in children. This study aimed to evaluate the efficacy and tolerability of EA 575 in pediatric patients with cough, via a literature review and expert survey. A MEDLINE/PubMed database search was performed to identify articles evaluating the efficacy and tolerability of EA 575 in pediatric patients with cough. An online survey of international pediatric cough experts was conducted to gather expert opinion regarding the use of EA 575 for pediatric cough. Ten controlled clinical trials and nine observational studies were identified. Controlled trials reported improvements in lung function and subjective cough symptoms with EA 575, while observational studies indicated overall favorable efficacy. EA 575 was generally well tolerated, with a low incidence of adverse events in children of all ages, including those aged <1 year. Survey responses from ten experts aligned with findings from the reviewed studies. Most experts agreed that EA 575 may improve quality of life, and highlighted its potential benefits on sleep. EA 575 has minimal side effects in pediatric patients with cough, as demonstrated by large, real-world studies. EA 575 may provide clinical benefits in pediatric patients; however, more robust clinical trials are needed to confirm its efficacy.
|
2023 Oct
|
Current medical research and opinion
|
No DOI
|
[
{
"LastName": "Seifert",
"FirstName": "Georg",
"Affiliation": "Department of Paediatric Oncology/Haematology, Otto-Heubner Centre for Paediatric and Adolescent Medicine (OHC), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany."
},
{
"LastName": "Upstone",
"FirstName": "Laura",
"Affiliation": "Cambridge - a Prime Global Agency, Knutsford, UK."
},
{
"LastName": "Watling",
"FirstName": "Christopher P",
"Affiliation": "Cambridge - a Prime Global Agency, Knutsford, UK."
},
{
"LastName": "Vogelberg",
"FirstName": "Christian",
"Affiliation": "Department of Paediatric Pneumology and Allergology, University Hospital Carl Gustav Carus Dresden, Technical University Dresden, Dresden, Germany."
}
] |
No
|
32043079
|
Quantizing Euclidean Motions via Double-Coset Decomposition.
|
Concepts from mathematical crystallography and group theory are used here to quantize the group of rigid-body motions, resulting in a "motion alphabet" with which robot motion primitives are expressed. From these primitives it is possible to develop a dictionary of physical actions. Equipped with an alphabet of the sort developed here, intelligent actions of robots in the world can be approximated with finite sequences of characters, thereby forming the foundation of a language in which robot motion is articulated. In particular, we use the discrete handedness-preserving symmetries of macromolecular crystals (known in mathematical crystallography as Sohncke space groups) to form a coarse discretization of the space SE(3) of rigid-body motions. This discretization is made finer by subdividing using the concept of double-coset decomposition. More specifically, a very efficient, equivolumetric quantization of spatial motion can be defined using the group-theoretic concept of a double-coset decomposition of the form Γ\SE(3)/Δ, where Γ is a Sohncke space group and Δ is a finite group of rotational symmetries such as those of the icosahedron. The resulting discrete alphabet is based on a very uniform sampling of SE(3) and is a tool for describing the continuous trajectories of robots and humans. An efficient coarse-to-fine search algorithm is presented to round off any motion sampled from the continuous group of motions to the nearest element of our alphabet. It is shown that our alphabet and this efficient rounding algorithm can be used as a geometric data structure to accelerate the performance of other sampling schemes designed for desirable dispersion or discrepancy properties. Moreover, the general "signals to symbols" problem in artificial intelligence is cast in this framework for robots moving continuously in the world.
|
2019
|
Research (Washington, D.C.)
|
No DOI
|
[
{
"LastName": "Wülker",
"FirstName": "Christian",
"Affiliation": "Johns Hopkins University, Baltimore, MD, USA."
},
{
"LastName": "Ruan",
"FirstName": "Sipu",
"Affiliation": "Johns Hopkins University, Baltimore, MD, USA."
},
{
"LastName": "Chirikjian",
"FirstName": "Gregory S",
"Affiliation": "Johns Hopkins University, Baltimore, MD, USA."
}
] |
No
|
9655725
|
Environmental tobacco smoke and adult asthma. The impact of changing exposure status on health outcomes.
|
The effect of environmental tobacco smoke (ETS) exposure on adults with asthma has not been well characterized. In a prospective cohort study of 451 nonsmoking adults with asthma, we evaluated the impact of ETS exposure on asthma severity, health status, and health care utilization over 18 mo. There were 129 subjects (29%; 95% CI, 25-33%) who reported regular ETS exposure, falling into three categories: exposure at baseline but none at follow-up (n = 43, 10%), no baseline exposure and new exposure at follow-up (n = 56, 12%), and exposure at both baseline and follow-up (n = 30, 7%). In cross-sectional analyses, subjects with baseline ETS exposure had greater severity-of-asthma scores (score difference, 1.7; 95% CI, 0. 2-3.1), worse asthma-specific quality of life scores (score difference, 3.5; 95% CI, 0.03-7.0), and worse scores on the Medical Outcomes Study SF-36 physical component summary (score difference, 3. 0; 95% CI, 0-6.0) than unexposed subjects. They also had greater odds of emergency department visits (odds ratio [OR] = 2.1; 95% CI, 1.2-3.5), urgent physician visits (OR = 1.9; 95% CI, 1.1-3.3), and hospitalizations (OR = 1.9; 95% CI, 1.02-3.6). In longitudinal follow-up, subjects reporting ETS cessation showed improvement in severity-of-asthma scores (score reduction, -3.2; 95% CI, -4.4 to -2. 0) and physical component summary scores (score increase, 5.3; 95% CI, 2.6-8.1). Environmental tobacco smoke cessation decreased the odds of emergency department visits (OR = 0.4; 95% CI, 0.2-0.97) and hospitalizations (OR = 0.2; 95% CI, 0.04-0.97) after adjustment for covariates. Environmental tobacco smoke initiation was associated with greater asthma severity only in subjects with high-level (>= 3 h/wk) exposure (score increase, 1.4; 95% CI, 0.03-2.7). In conclusion, self-reported ETS exposure is associated with greater asthma severity, worse health status, and increased health care utilization in adults with asthma.
|
1998 Jul
|
American journal of respiratory and critical care medicine
|
No DOI
|
[
{
"LastName": "Eisner",
"FirstName": "M D",
"Affiliation": "Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA, USA."
},
{
"LastName": "Yelin",
"FirstName": "E H",
"Affiliation": ""
},
{
"LastName": "Henke",
"FirstName": "J",
"Affiliation": ""
},
{
"LastName": "Shiboski",
"FirstName": "S C",
"Affiliation": ""
},
{
"LastName": "Blanc",
"FirstName": "P D",
"Affiliation": ""
}
] |
Yes
|
36266717
|
Reprogramming of sentinel lymph node microenvironment during tumor metastasis.
|
Metastasis is a major cause of death in patients with cancer. The two main routes for cancer cell dissemination are the blood and lymphatic systems. The underlying mechanism of hematogenous metastasis has been well characterized in the past few decades. However, our understanding of the molecular basis of lymphatic metastasis remains at a premature stage. Conceptually, cancer cells invade into lymphatic capillary, passively move to collecting lymphatic vessels, migrate into sentinel lymph node (SLN;, the first lymph node to which cancer cells spread from the primary tumor), and enter the blood circulatory system via the subclavian vein. Before arriving, cancer cells release specific soluble factors to modulate the microenvironment in SLN to establish a beachhead for successful colonization. After colonization, cancer cells inhibit anti-tumor immunity by inducing the recruitment of regulatory T cell and myeloid-derived suppressor cells, suppressing the function of dendritic cell and CD8[+] T cell, and promoting the release of immunosuppressive cytokines. The development of novel strategies to reverse cancer cell-triggered SLN remodeling may re-activate immunity to reduce beachhead buildup and distant metastasis. In addition to being a microanatomic location for metastasis, the SLN is also an important site for immune modulation. Nanotechnology-based approaches to deliver lymph node-tropic antibodies or drug-conjugated nanoparticles to kill cancer cells on site are a new direction for cancer treatment. Conversely, the induction of stronger immunity by promoting antigen presentation in lymph nodes provides an alternate way to enhance the efficacy of immune checkpoint therapy and cancer vaccine. In this review article, we summarize recent findings on the reprogramming of SLN during lymphatic invasion and discuss the possibility of inhibiting tumor metastasis and eliciting anti-tumor immunity by targeting SLN.
|
2022 Oct 20
|
Journal of biomedical science
|
No DOI
|
[
{
"LastName": "Li",
"FirstName": "Yen-Liang",
"Affiliation": "National Institute of Cancer Research, National Health Research Institutes, Tainan, 704, Taiwan."
},
{
"LastName": "Hung",
"FirstName": "Wen-Chun",
"Affiliation": "National Institute of Cancer Research, National Health Research Institutes, Tainan, 704, Taiwan. [email protected]."
}
] |
No
|
35140695
|
Relative and Quantitative Rhizosphere Microbiome Profiling Results in Distinct Abundance Patterns.
|
Next-generation sequencing is one of the most popular and cost-effective ways of characterizing microbiome in multiple samples. However, most of the currently available amplicon sequencing approaches are limited, as they result in relative abundance profiles of microbial taxa, which does not represent actual abundance in the environment. Here, we combined amplicon sequencing (16S rRNA gene for bacteria and ITS region for fungi) with real-time quantitative PCR (qPCR) to characterize the rhizosphere microbiome of wheat. We show that changes in the relative abundance of major microbial phyla do not necessarily follow the same pattern as the estimated quantitative abundance. Most of the bacterial phyla linked with the rhizosphere of plants grown in soil with no history of water stress showed enrichment patterns in their estimated absolute abundance, which was in contradiction with the trends observed in the relative abundance data. However, in the case of the fungal groups (except for Basidiomycota), such an enrichment pattern was not observed and the abundance of fungi remained relatively unchanged under different soil water stress history when estimated absolute abundance was considered. Comparing relative and estimated absolute abundances of dominant bacterial and fungal phyla, as well as their correlation with the functional processes in the rhizosphere, our results suggest that the estimated absolute abundance approach gives a different and more realistic perspective than the relative abundance approach. Such a quantification approach provides complementary information that helps to better understand the rhizosphere microbiomes and their associated ecological functional processes.
|
2021
|
Frontiers in microbiology
|
No DOI
|
[
{
"LastName": "Azarbad",
"FirstName": "Hamed",
"Affiliation": "Evolutionary Ecology of Plants, Faculty of Biology, Philipps-University Marburg, Marburg, Germany."
},
{
"LastName": "Tremblay",
"FirstName": "Julien",
"Affiliation": "Energy, Mining and Environment, National Research Council Canada, Montréal, QC, Canada."
},
{
"LastName": "Bainard",
"FirstName": "Luke D",
"Affiliation": "Swift Current Research and Development Centre, Agriculture and Agri-Food Canada, Swift Current, SK, Canada."
},
{
"LastName": "Yergeau",
"FirstName": "Etienne",
"Affiliation": "Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, QC, Canada."
}
] |
No
|
12358731
|
The production of hydrogen sulfide is regulated by testosterone and S-adenosyl-L-methionine in mouse brain.
|
Hydrogen sulfide (H2S) is endogenously produced in the brain from L-cysteine by the enzyme cystathionine beta-synthase (CBS) and functions as a neuromodulator in the brain. H2S selectively enhances NMDA receptor-mediated responses and alters hippocampal long-term potentiation (LTP). The production of H2S is regulated by Ca2+/calmodulin-mediated pathways and is enhanced in response to neuronal excitation. In addition to this fast regulation, we describe here a slower form of the regulation of H2S production by testosterone and S-adenosyl-L-methionine (SAM), a CBS activator. Endogenous H2S in the mouse brain increases after birth, reaches a maximum level at 8 weeks and then decreases. Female brain contains less H2S than male brain at each age. A single administration of testosterone to female mice increases the endogenous H2S and SAM, which reach levels similar to those of male mice. In contrast, castration of male mice decreases the levels of testosterone, SAM and H2S in the brain. Administration of SAM once a day for 3 days increases the brain H2S without significantly changing the testosterone level. These observations suggest that testosterone can regulate the brain H2S level via changing the level of SAM.
|
2002 Oct
|
Journal of neurochemistry
|
No DOI
|
[
{
"LastName": "Eto",
"FirstName": "Ko",
"Affiliation": "National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8551, Japan."
},
{
"LastName": "Kimura",
"FirstName": "Hideo",
"Affiliation": ""
}
] |
Yes
|
34511935
|
Occurrence, Related Factors and Prognostic Value of Vascular Lake in Hepatocellular Carcinoma Patients Treated with Drug-Eluting Bead Transarterial Chemoembolization.
|
The present study aimed to assess the prevalence of vascular lake (VL), its associated factors and correlation with prognosis in hepatocellular carcinoma (HCC) patients treated with drug-eluting bead transarterial chemoembolization (DEB-TACE). A total of 286 primary HCC patients (with 384 treated nodules) receiving DEB-TACE treatment were recruited, and their clinical characteristics were documented. The occurrence of VL was recorded, and treatment responses were assessed according to the modified response evaluation criteria in solid tumor (mRECIST).In terms of treatment response, the total response status (including CR, PR, SD and PD), objective response rate (ORR) and disease control rate (DCR) were elevated in VL patients compared to non-VL patients as well as in VL nodules compared to non-VL nodules. Liver function indexes and adverse events were assessed. Progression-free survival (PFS) and overall survival (OS) were evaluated with the last follow-up date of March 2020. The patient-based and nodule-based VL occurrence rates were 17.1% and 16.4%, respectively. Larger tumor size, pseudocapsules and smaller bead size were independently associated with VL occurrence. PFS and OS were more prolonged in VL patients than in non-VL patients, and VL independently correlated with better PFS and OS. For liver function, the liver function indexes before and after DEB-TACE were of no difference between VL patients and non-VL patients. Additionally, the incidences of adverse events were similar between VL patients and non-VL patients. VL occurs in 17.1% of HCC patients treated with DEB-TACE, and it is correlated with larger tumor size, pseudocapsule, smaller bead size, more favorable treatment response and better survival.
|
2021
|
OncoTargets and therapy
|
No DOI
|
[
{
"LastName": "Li",
"FirstName": "Hao",
"Affiliation": "Department of Interventional Radiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People's Republic of China."
},
{
"LastName": "Wang",
"FirstName": "Manzhou",
"Affiliation": "Department of Interventional Radiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People's Republic of China."
},
{
"LastName": "Chen",
"FirstName": "Pengfei",
"Affiliation": "Department of Interventional Radiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People's Republic of China."
},
{
"LastName": "Li",
"FirstName": "Fangzheng",
"Affiliation": "Department of Interventional Radiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People's Republic of China."
},
{
"LastName": "Kuang",
"FirstName": "Donglin",
"Affiliation": "Department of Interventional Radiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People's Republic of China."
},
{
"LastName": "Han",
"FirstName": "Xinwei",
"Affiliation": "Department of Interventional Radiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People's Republic of China."
},
{
"LastName": "Ren",
"FirstName": "Jianzhuang",
"Affiliation": "Department of Interventional Radiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People's Republic of China."
},
{
"LastName": "Duan",
"FirstName": "Xuhua",
"Affiliation": "Department of Interventional Radiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People's Republic of China."
}
] |
No
|
25593724
|
A glance at methods for cleft palate repair.
|
Cleft palate is the second most common birth defect and is considered as a challenge for pediatric plastic surgeons. There is still a general lack of a standard protocol and patients often require multiple surgical interventions during their lifetime along with disappointing results. PubMed search was undertaken using search terms including 'cleft palate repair', 'palatal cleft closure', 'cleft palate + stem cells', 'cleft palate + plasma rich platelet', 'cleft palate + scaffold', 'palatal tissue engineering', and 'bone tissue engineering'. The found articles were included if they defined a therapeutic strategy and/or assessed a new technique. We reported a summary of the key-points concerning cleft palate development, the genes involving this defect, current therapeutic strategies, recently novel aspects, and future advances in treatments for easy and fast understanding of the concepts, rather than a systematic review. In addition, the results were integrated with our recent experience. Tissue engineering may open a new window in cleft palate reconstruction. Stem cells and growth factors play key roles in this field.
|
2014 Sep
|
Iranian Red Crescent medical journal
|
No DOI
|
[
{
"LastName": "Tavakolinejad",
"FirstName": "Sima",
"Affiliation": "Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran."
},
{
"LastName": "Ebrahimzadeh Bidskan",
"FirstName": "Alireza",
"Affiliation": "Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran."
},
{
"LastName": "Ashraf",
"FirstName": "Hami",
"Affiliation": "Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran."
},
{
"LastName": "Hamidi Alamdari",
"FirstName": "Daryoush",
"Affiliation": "Biochemistry and Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran."
}
] |
No
|
38985813
|
Psychological distress and its associated factors among people with specific chronic conditions (diabetes and/or hypertension) in the Sidama region of southern Ethiopia: A cross-sectional study.
|
The majority of people with long-term, non-communicable medical conditions experience significant psychological anguish. Poor mental health or psychological distress influences low lifestyle decisions that result in obesity, inactivity, and cigarette use as well as poor health literacy and limited access to health promotion activities. The study's purpose was to measure the prevalence of psychological distress and it's predictors in patients with chronic non-communicable diseases who were being treated in selected hospitals in the Sidama region of southern Ethiopia in 2022. Institutional based cross-sectional study was carried out using a sample of 844 patients receiving medication for either high blood pressure or diabetes mellitus or both between May1 and August 31, 2022. To gauge psychiatric distress, the Amharic translation and Ethiopian validation of the Kessler 6 scale (K-6) was employed. The analysis was done using binary logistic regression and an odds ratio with the corresponding 95% confidence interval was estimated to measure the strength of the association. P value <0.05 was considered to declare the significance. Patients with diabetic mellitus, hypertension or both had a 49.6% prevalence of psychological distress at selected Sidama hospitals. Age, drug side effects, history medical complications following diabetic mellitus/hypertension, and body mass index of the patient were all significantly linked with psychological distress (P<0.05). According to the results of this study, psychological distress is far more prevalent than it was in past studies in Ethiopia and other African countries. To lessen the problem, all stakeholders must cooperate, but health agencies, policymakers, and NGOs particularly need to put in extra effort. The study also showed a significant association between body mass index, patient age, drug side effects, and history of medical complications following diabetic mellitus /hypertension.
|
2024
|
PloS one
|
No DOI
|
[
{
"LastName": "Borie",
"FirstName": "Yacob Abraham",
"Affiliation": "Department of Psychiatry, College of Medicine and Health Science, Hawassa University, Hawassa, Ethiopia."
},
{
"LastName": "Tamiso",
"FirstName": "Alemu",
"Affiliation": "School of Public Health, College of Medicine and Health Science, Hawassa University, Ethiopia."
},
{
"LastName": "Gutema",
"FirstName": "Keneni",
"Affiliation": "School of Public Health, College of Medicine and Health Science, Hawassa University, Ethiopia."
},
{
"LastName": "Jisso",
"FirstName": "Meskerem",
"Affiliation": "School of Public Health, College of Medicine and Health Science, Hawassa University, Ethiopia."
},
{
"LastName": "Deribe",
"FirstName": "Bedilu",
"Affiliation": "School of Public Health, College of Medicine and Health Science, Hawassa University, Ethiopia."
},
{
"LastName": "Fikre",
"FirstName": "Rekiku",
"Affiliation": "Department of Midwifery, College of Medicine and Health Science, Hawassa University, Hawassa, Ethiopia."
},
{
"LastName": "Defar",
"FirstName": "Semira",
"Affiliation": "Department of Midwifery, College of Medicine and Health Science, Hawassa University, Hawassa, Ethiopia."
},
{
"LastName": "Ayalew",
"FirstName": "Mohammed",
"Affiliation": "Department of Psychiatry, College of Medicine and Health Science, Hawassa University, Hawassa, Ethiopia."
},
{
"LastName": "Abera",
"FirstName": "Wondwossen",
"Affiliation": "School of Medical Laboratory, College of Medicine and Health Science, Hawassa University, Hawassa, Ethiopia."
}
] |
No
|
37219943
|
Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma.
|
Recent transcriptomic-based analysis of diffuse large B cell lymphoma (DLBCL) has highlighted the clinical relevance of LN fibroblast and tumor-infiltrating lymphocyte (TIL) signatures within the tumor microenvironment (TME). However, the immunomodulatory role of fibroblasts in lymphoma remains unclear. Here, by studying human and mouse DLBCL-LNs, we identified the presence of an aberrantly remodeled fibroblastic reticular cell (FRC) network expressing elevated fibroblast-activated protein (FAP). RNA-Seq analyses revealed that exposure to DLBCL reprogrammed key immunoregulatory pathways in FRCs, including a switch from homeostatic to inflammatory chemokine expression and elevated antigen-presentation molecules. Functional assays showed that DLBCL-activated FRCs (DLBCL-FRCs) hindered optimal TIL and chimeric antigen receptor (CAR) T cell migration. Moreover, DLBCL-FRCs inhibited CD8+ TIL cytotoxicity in an antigen-specific manner. Notably, the interrogation of patient LNs with imaging mass cytometry identified distinct environments differing in their CD8+ TIL-FRC composition and spatial organization that associated with survival outcomes. We further demonstrated the potential to target inhibitory FRCs to rejuvenate interacting TILs. Cotreating organotypic cultures with FAP-targeted immunostimulatory drugs and a bispecific antibody (glofitamab) augmented antilymphoma TIL cytotoxicity. Our study reveals an immunosuppressive role of FRCs in DLBCL, with implications for immune evasion, disease pathogenesis, and optimizing immunotherapy for patients.
|
2023 Jul 3
|
The Journal of clinical investigation
|
No DOI
|
[
{
"LastName": "Apollonio",
"FirstName": "Benedetta",
"Affiliation": "School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom."
},
{
"LastName": "Spada",
"FirstName": "Filomena",
"Affiliation": "BRC Advanced Cytometry Platform and."
},
{
"LastName": "Petrov",
"FirstName": "Nedyalko",
"Affiliation": "BRC Advanced Cytometry Platform and."
},
{
"LastName": "Cozzetto",
"FirstName": "Domenico",
"Affiliation": "BRC Translational Bioinformatics at Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom."
},
{
"LastName": "Papazoglou",
"FirstName": "Despoina",
"Affiliation": "School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom."
},
{
"LastName": "Jarvis",
"FirstName": "Peter",
"Affiliation": "5th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece."
},
{
"LastName": "Kannambath",
"FirstName": "Shichina",
"Affiliation": "BRC Genomics Research Platform at Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom."
},
{
"LastName": "Terranova-Barberio",
"FirstName": "Manuela",
"Affiliation": "BRC Advanced Cytometry Platform and."
},
{
"LastName": "Amini",
"FirstName": "Rose-Marie",
"Affiliation": "Department of Immunology, Genetics and Pathology, Uppsala University and Hospital, Uppsala, Sweden."
},
{
"LastName": "Enblad",
"FirstName": "Gunilla",
"Affiliation": "Department of Immunology, Genetics and Pathology, Uppsala University and Hospital, Uppsala, Sweden."
},
{
"LastName": "Graham",
"FirstName": "Charlotte",
"Affiliation": "School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom."
},
{
"LastName": "Benjamin",
"FirstName": "Reuben",
"Affiliation": "School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom."
},
{
"LastName": "Phillips",
"FirstName": "Elisabeth",
"Affiliation": "School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom."
},
{
"LastName": "Ellis",
"FirstName": "Richard",
"Affiliation": "BRC Advanced Cytometry Platform and."
},
{
"LastName": "Nuamah",
"FirstName": "Rosamond",
"Affiliation": "BRC Genomics Research Platform at Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom."
},
{
"LastName": "Saqi",
"FirstName": "Mansoor",
"Affiliation": "BRC Translational Bioinformatics at Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom."
},
{
"LastName": "Calado",
"FirstName": "Dinis P",
"Affiliation": "Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom."
},
{
"LastName": "Rosenquist",
"FirstName": "Richard",
"Affiliation": "Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden."
},
{
"LastName": "Sutton",
"FirstName": "Lesley A",
"Affiliation": "Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden."
},
{
"LastName": "Salisbury",
"FirstName": "Jon",
"Affiliation": "Department of Haematology, King's College Hospital NHS Foundation Trust, London, United Kingdom."
},
{
"LastName": "Zacharioudakis",
"FirstName": "Georgios",
"Affiliation": "5th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece."
},
{
"LastName": "Vardi",
"FirstName": "Anna",
"Affiliation": "Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece."
},
{
"LastName": "Hagner",
"FirstName": "Patrick R",
"Affiliation": "Bristol-Myers Squibb, Summit, New Jersey, USA."
},
{
"LastName": "Gandhi",
"FirstName": "Anita K",
"Affiliation": "Bristol-Myers Squibb, Summit, New Jersey, USA."
},
{
"LastName": "Bacac",
"FirstName": "Marina",
"Affiliation": "Roche Innovation Center Zurich, Schlieren, Switzerland."
},
{
"LastName": "Claus",
"FirstName": "Christina",
"Affiliation": "Roche Innovation Center Zurich, Schlieren, Switzerland."
},
{
"LastName": "Umana",
"FirstName": "Pablo",
"Affiliation": "Roche Innovation Center Zurich, Schlieren, Switzerland."
},
{
"LastName": "Jarrett",
"FirstName": "Ruth F",
"Affiliation": "MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom."
},
{
"LastName": "Klein",
"FirstName": "Christian",
"Affiliation": "Roche Innovation Center Zurich, Schlieren, Switzerland."
},
{
"LastName": "Deutsch",
"FirstName": "Alexander",
"Affiliation": "Division of Hematology, Medical University of Graz, Graz, Austria."
},
{
"LastName": "Ramsay",
"FirstName": "Alan G",
"Affiliation": "School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom."
}
] |
No
|
39003263
|
Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control differentiation in multicellular constructs.
|
Synthetic Notch (synNotch) receptors are genetically encoded, modular synthetic receptors that enable mammalian cells to detect environmental signals and respond by activating user-prescribed transcriptional programs. Although some materials have been modified to present synNotch ligands with coarse spatial control, applications in tissue engineering generally require extracellular matrix (ECM)-derived scaffolds and/or finer spatial positioning of multiple ligands. Thus, we develop here a suite of materials that activate synNotch receptors for generalizable engineering of material-to-cell signaling. We genetically and chemically fuse functional synNotch ligands to ECM proteins and ECM-derived materials. We also generate tissues with microscale precision over four distinct reporter phenotypes by culturing cells with two orthogonal synNotch programs on surfaces microcontact-printed with two synNotch ligands. Finally, we showcase applications in tissue engineering by co-transdifferentiating fibroblasts into skeletal muscle or endothelial cell precursors in user-defined micropatterns. These technologies provide avenues for spatially controlling cellular phenotypes in mammalian tissues.
|
2024 Jul 13
|
Nature communications
|
No DOI
|
[
{
"LastName": "Garibyan",
"FirstName": "Mher",
"Affiliation": "Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA."
},
{
"LastName": "Hoffman",
"FirstName": "Tyler",
"Affiliation": "Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA."
},
{
"LastName": "Makaske",
"FirstName": "Thijs",
"Affiliation": "Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA."
},
{
"LastName": "Do",
"FirstName": "Stephanie K",
"Affiliation": "Alfred E. Mann Department of Biomedical Engineering, USC Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA."
},
{
"LastName": "Wu",
"FirstName": "Yifan",
"Affiliation": "Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA."
},
{
"LastName": "Williams",
"FirstName": "Brian A",
"Affiliation": "Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA."
},
{
"LastName": "March",
"FirstName": "Alexander R",
"Affiliation": "Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA."
},
{
"LastName": "Cho",
"FirstName": "Nathan",
"Affiliation": "Alfred E. Mann Department of Biomedical Engineering, USC Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA."
},
{
"LastName": "Pedroncelli",
"FirstName": "Nicolas",
"Affiliation": "Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA."
},
{
"LastName": "Lima",
"FirstName": "Ricardo Espinosa",
"Affiliation": "Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA."
},
{
"LastName": "Soto",
"FirstName": "Jennifer",
"Affiliation": "Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA."
},
{
"LastName": "Jackson",
"FirstName": "Brooke",
"Affiliation": "Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA."
},
{
"LastName": "Santoso",
"FirstName": "Jeffrey W",
"Affiliation": "Alfred E. Mann Department of Biomedical Engineering, USC Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA."
},
{
"LastName": "Khademhosseini",
"FirstName": "Ali",
"Affiliation": "Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA."
},
{
"LastName": "Thomson",
"FirstName": "Matt",
"Affiliation": "Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA."
},
{
"LastName": "Li",
"FirstName": "Song",
"Affiliation": "Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA."
},
{
"LastName": "McCain",
"FirstName": "Megan L",
"Affiliation": "Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA. [email protected]."
},
{
"LastName": "Morsut",
"FirstName": "Leonardo",
"Affiliation": "Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA. [email protected]."
}
] |
No
|
33500662
|
Columbamine-Mediated PTEN/AKT Signal Pathway Regulates the Progression of Glioma.
|
At present, comprehensive therapy has been widely used in the treatment of glioma, but the curative effect is not good, and the survival rate of patients is low. Therefore, it is crucial to explore further the regulatory mechanism of the occurrence and development of glioma and find potential therapeutic targets. We aimed to investigate the columbamine (a tetrahydroisoquinoline alkaloid derived from the rhizome of Chinese herbal medicine Rhizoma Coptidis) on glioma progression. MTT, clone formation assay, wound healing assay, and transwell assay were performed to detect the cell viability, proliferation, migration, and invasion ability. Flow cytometry, TUNEL, and Western blot were used to identify the apoptosis level in glioma cells. PTEN inhibitor (SF1670) and AKT activator (SC79) were used to explore the mechanism of columbamine on glioma cell progression. Columbamine inhibits proliferation, migration, invasion, and induces apoptosis in glioma cell lines (SHG44 and U251). Columbamine prevents phosphorylation of AKT and promotes the expression of PTEN. Blocking PTEN level or inducing phosphorylation of AKT attenuates columbamine function on SHG44 cells proliferation, metastasis, and apoptosis. In this research, we find that columbamine could inhibit proliferation and metastasis of glioma cell lines, and promote apoptosis of glioma cell lines via regulating PTEN/AKT signal pathway. It provides a new theoretical basis for the development of anti-glioma drugs.
|
2021
|
Cancer management and research
|
No DOI
|
[
{
"LastName": "Niu",
"FirstName": "Hai-Tao",
"Affiliation": "Department of Neurosurgery, Cangzhou Central Hospital, Cangzhou, Hebei 061000, People's Republic of China."
},
{
"LastName": "Liu",
"FirstName": "Yang",
"Affiliation": "Department of Neurosurgery, Cangzhou Central Hospital, Cangzhou, Hebei 061000, People's Republic of China."
},
{
"LastName": "Wang",
"FirstName": "Yan-Zhou",
"Affiliation": "Department of Neurosurgery, Cangzhou Central Hospital, Cangzhou, Hebei 061000, People's Republic of China."
},
{
"LastName": "Tian",
"FirstName": "Yong",
"Affiliation": "Department of Neurosurgery, Cangzhou Central Hospital, Cangzhou, Hebei 061000, People's Republic of China."
},
{
"LastName": "Yang",
"FirstName": "Ming",
"Affiliation": "Department of Neurosurgery, Cangzhou Central Hospital, Cangzhou, Hebei 061000, People's Republic of China."
},
{
"LastName": "Jiang",
"FirstName": "Hong-Sheng",
"Affiliation": "Department of Neurosurgery, Cangzhou Central Hospital, Cangzhou, Hebei 061000, People's Republic of China."
}
] |
Yes
|
22359953
|
[Genetic manipulation and studying of differentiation properties of rat induced pluripotent stem cells].
|
Induced pluripotent stem (iPS) cells are derived from somatic cells reprogrammed to the pluripotent state by the induced expression of defined transcription factors, achieved for the first time by the seminal work of Takahashi and Yamanaka. This new type of pluripotent cells has offered new exciting options in regenerative medicine allowing the replacement of cells and organs with the patient's own cells thereby avoiding immunological complications. In order to develop such technologies in approved animal models, iPS cells were also generated from rodents. Of course, the most important model for studying of different diseases is rat. In this study, we present a method suitable for rat iPS cells genetic modification by stable transfection and show necessary conditions for the first stages of direct differentiation.
|
2011
|
Tsitologiia
|
No DOI
|
[
{
"LastName": "Liskovykh",
"FirstName": "M A",
"Affiliation": ""
},
{
"LastName": "Chuĭkin",
"FirstName": "I A",
"Affiliation": ""
},
{
"LastName": "Ranjan",
"FirstName": "A",
"Affiliation": ""
},
{
"LastName": "Popova",
"FirstName": "E",
"Affiliation": ""
},
{
"LastName": "Tolkunova",
"FirstName": "E N",
"Affiliation": ""
},
{
"LastName": "Chechik",
"FirstName": "L L",
"Affiliation": ""
},
{
"LastName": "Malinin",
"FirstName": "A Iu",
"Affiliation": ""
},
{
"LastName": "Morozova",
"FirstName": "A V",
"Affiliation": ""
},
{
"LastName": "Mosienko",
"FirstName": "V",
"Affiliation": ""
},
{
"LastName": "Bader",
"FirstName": "M",
"Affiliation": ""
},
{
"LastName": "alenina",
"FirstName": "N",
"Affiliation": ""
},
{
"LastName": "Tomilin",
"FirstName": "A N",
"Affiliation": ""
}
] |
No
|
30637145
|
Diversity and Bioactive Potential of Culturable Fungal Endophytes of Medicinal Shrub Berberis aristata DC.: A First Report.
|
Bioactive natural compounds, isolated from fungal endophytes, play a promising role in the search for novel drugs. They are an inspiring source for researchers due to their enormous structural diversity and complexity. During the present study fungal endophytes were isolated from a well-known medicinal shrub, Berberis aristata DC. and were explored for their antagonistic and antioxidant potential. B. aristata, an important medicinal shrub with remarkable pharmacological properties, is native to Northern Himalayan region. A total of 131 endophytic fungal isolates belonging to eighteen species and nine genera were obtained from three hundred and thirty surface sterilized segments of different tissues of B. aristata. The isolated fungi were classified on the basis of morphological and molecular analysis. Diversity and species richness was found to be higher in leaf tissues as compared to root and stem. Antibacterial activity demonstrated that the crude ethyl acetate extract of 80% isolates exhibited significant results against one or more bacterial pathogens. Ethyl acetate extract of Alternaria macrospora was found to have potential antibacterial activity. Significant antioxidant activity was also found in crude ethyl acetate extracts of Alternaria alternata and Aspergillus flavus. Similarly, antagonistic activity of the fungal endophytes revealed that all antagonists possessed inhibition potential against more than one fungal pathogen. This study is an important step towards tapping endophytic fungal diversity for bioactive metabolites which could be a step forward towards development of novel therapeutic agents.
|
2018
|
Mycobiology
|
No DOI
|
[
{
"LastName": "Sharma",
"FirstName": "Supriya",
"Affiliation": "School of Biotechnology, University of Jammu, Jammu, J&K, India."
},
{
"LastName": "Gupta",
"FirstName": "Suruchi",
"Affiliation": "School of Biotechnology, University of Jammu, Jammu, J&K, India."
},
{
"LastName": "Dhar",
"FirstName": "Manoj K",
"Affiliation": "School of Biotechnology, University of Jammu, Jammu, J&K, India."
},
{
"LastName": "Kaul",
"FirstName": "Sanjana",
"Affiliation": "School of Biotechnology, University of Jammu, Jammu, J&K, India."
}
] |
No
|
38513024
|
The propensity for covalent organic frameworks to template polymer entanglement.
|
The introduction of molecularly woven three-dimensional (3D) covalent organic framework (COF) crystals into polymers of varying types invokes different forms of contact between filler and polymer. Whereas the combination of woven COFs with amorphous and brittle polymethyl methacrylate results in surface interactions, the use of the liquid-crystalline polymer polyimide induces the formation of polymer-COF junctions. These junctions are generated by the threading of polymer chains through the pores of the nanocrystals, thus allowing for spatial arrangement of polymer strands. This offers a programmable pathway for unthreading polymer strands under stress and leads to the in situ formation of high-aspect-ratio nanofibrils, which dissipate energy during the fracture. Polymer-COF junctions also strengthen the filler-matrix interfaces and lower the percolation thresholds of the composites, enhancing strength, ductility, and toughness of the composites by adding small amounts (~1 weight %) of woven COF nanocrystals. The ability of the polymer strands to closely interact with the woven framework is highlighted as the main parameter to forming these junctions, thus affecting polymer chain penetration and conformation.
|
2024 Mar 22
|
Science (New York, N.Y.)
|
No DOI
|
[
{
"LastName": "Neumann",
"FirstName": "S Ephraim",
"Affiliation": "Department of Chemistry, University of California-Berkeley, Berkeley, CA 94720, USA."
},
{
"LastName": "Kwon",
"FirstName": "Junpyo",
"Affiliation": "Department of Mechanical Engineering, University of California-Berkeley, Berkeley, CA 94720, USA."
},
{
"LastName": "Gropp",
"FirstName": "Cornelius",
"Affiliation": "Department of Chemistry, University of California-Berkeley, Berkeley, CA 94720, USA."
},
{
"LastName": "Ma",
"FirstName": "Le",
"Affiliation": "Materials Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA."
},
{
"LastName": "Giovine",
"FirstName": "Raynald",
"Affiliation": "Department of Chemistry, University of California-Berkeley, Berkeley, CA 94720, USA."
},
{
"LastName": "Ma",
"FirstName": "Tianqiong",
"Affiliation": "Department of Chemistry, University of California-Berkeley, Berkeley, CA 94720, USA."
},
{
"LastName": "Hanikel",
"FirstName": "Nikita",
"Affiliation": "Department of Chemistry, University of California-Berkeley, Berkeley, CA 94720, USA."
},
{
"LastName": "Wang",
"FirstName": "Kaiyu",
"Affiliation": "Department of Chemistry, University of California-Berkeley, Berkeley, CA 94720, USA."
},
{
"LastName": "Chen",
"FirstName": "Tiffany",
"Affiliation": "Department of Chemistry, University of California-Berkeley, Berkeley, CA 94720, USA."
},
{
"LastName": "Jagani",
"FirstName": "Shaan",
"Affiliation": "Department of Materials Science & Engineering, University of California-Berkeley, Berkeley, CA 94720, USA."
},
{
"LastName": "Ritchie",
"FirstName": "Robert O",
"Affiliation": "Department of Mechanical Engineering, University of California-Berkeley, Berkeley, CA 94720, USA."
},
{
"LastName": "Xu",
"FirstName": "Ting",
"Affiliation": "Department of Chemistry, University of California-Berkeley, Berkeley, CA 94720, USA."
},
{
"LastName": "Yaghi",
"FirstName": "Omar M",
"Affiliation": "Department of Chemistry, University of California-Berkeley, Berkeley, CA 94720, USA."
}
] |
No
|
38354480
|
Reality check. The issue of social plausibility in Virtual reality therapy with addiction patients.
|
In France, virtual reality has been experimented since 2016 to address addictive behaviors. The existing literature insists on the "immersive" dimension of the technology as a significant factor in the efficacy of exposure. An ethnographic approach, however, suggests that the realism criterion should be reassessed. Based on a fieldwork conducted in the addictology department of a French hospital that made use of Virtual reality therapy (VRT), the article shows that it is a form of technical reiteration designed to develop reflexivity about one's actions, provoking the craving so that it can be domesticated. The patient's engagement in "as if" mode is facilitated by the therapist's work in mapping the patient's addictive practices, personalizing the exposure situations, and elaborating the simulation as being part of a practical experiment. While the question of graphic realism does not seem especially problematic, the question of social plausibility can put the simulation operation under strain.
|
2024 Mar
|
Social science & medicine (1982)
|
No DOI
|
[
{
"LastName": "Borelle",
"FirstName": "Céline",
"Affiliation": "CEMS (EHESS-CNRS-INSERM), France; SENSE (Orange), France. Electronic address: [email protected]."
},
{
"LastName": "Forner",
"FirstName": "Elsa",
"Affiliation": "CEMS (EHESS-CNRS-INSERM), France. Electronic address: [email protected]."
}
] |
No
|
32783604
|
Predicting marriage and divorce in obsessive-compulsive disorder.
|
Single (N = 472, 51.7%), married or living in stable cohabitation (N = 375, 41.1%) and divorced or separated (N = 66, 7.2%) patients with obsessive-compulsive disorder (OCD) were compared in terms of their sociodemographic features, OCD phenotypes, and comorbidity profile. Using single status as a reference group, a multinominal regression analysis found increased age, lower severity of hoarding, increased rates of panic disorder without agoraphobia, and lower rates of dysthymic disorder to be associated with married or stable cohabitation status. Concomitantly, increased age, higher severity of symmetry symptoms, and increased rates of skin picking disorder were found to be associated with divorced status. These findings suggest that there is a relationship between marital status and different OCD phenotypes.
|
2021
|
Journal of sex & marital therapy
|
No DOI
|
[
{
"LastName": "Muhlbauer",
"FirstName": "Julia E",
"Affiliation": "Obsessive, Compulsive, and Anxiety Spectrum Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil."
},
{
"LastName": "Ferrão",
"FirstName": "Ygor A",
"Affiliation": "Department of Psychiatry, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil."
},
{
"LastName": "Eppingstall",
"FirstName": "Jan",
"Affiliation": "Turner Institute for Brain and Mental Health, Monash University, Clayton, Australia."
},
{
"LastName": "Albertella",
"FirstName": "Lucy",
"Affiliation": "Turner Institute for Brain and Mental Health, Monash University, Clayton, Australia."
},
{
"LastName": "do Rosário",
"FirstName": "Maria C",
"Affiliation": "Department of Psychiatry, Federal University of São Paulo (UNIFESP), São Paulo, Brazil."
},
{
"LastName": "Miguel",
"FirstName": "Euripedes C",
"Affiliation": "Obsessive-Compulsive Spectrum Disorders Program (PROTOC), Department and Institute of Psychiatry, University of São Paulo (USP), São Paulo, Brazil."
},
{
"LastName": "Fontenelle",
"FirstName": "Leonardo F",
"Affiliation": "Obsessive, Compulsive, and Anxiety Spectrum Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil."
}
] |
No
|
31950703
|
Hollow Polypyrrole Nanospindles for Highly Effective Cancer Therapy.
|
Polypyrrole (PPy) hollow nanostructures continue to attract the interest researchers because of their good biocompatibility, high photothermal conversion efficiency, and excellent stability. The preparation of PPy hollow nanostructures by the hard templating method without complicated post-synthetic treatment and additional oxidizing agents remains a challenge. In this work, we report a facile and novel hard templating method to fabricate hollow PPy nanospindles in which MIL-88(Fe) serves as the template. Fe[3+] centers in MIL-88(Fe) could induce the polymerization of pyrrole to construct the shell, and MIL-88(Fe) would be decomposed by solvent water. This method did not require any extra oxidizing agents and post-synthetic treatment. Hollow PPy nanospindles exhibit excellent photothermal and drug loading ability, and the therapy effect of cancer was significant. This method provides a new hard templating approach for the synthesis of polymer hollow nanostructures.
|
2018 Dec
|
ChemPlusChem
|
No DOI
|
[
{
"LastName": "Chen",
"FirstName": "Yixin",
"Affiliation": "State Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, 130012, P. R. China."
},
{
"LastName": "Xiang",
"FirstName": "Siyuan",
"Affiliation": "State Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, 130012, P. R. China."
},
{
"LastName": "Wang",
"FirstName": "Lu",
"Affiliation": "Department of Oral Pathology School and Hospital of Stomatology, Jilin University, Changchun, 130021, P. R. China."
},
{
"LastName": "Wang",
"FirstName": "Mingyue",
"Affiliation": "State Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, 130012, P. R. China."
},
{
"LastName": "Wang",
"FirstName": "Congcong",
"Affiliation": "State Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, 130012, P. R. China."
},
{
"LastName": "Liu",
"FirstName": "Shuwei",
"Affiliation": "State Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, 130012, P. R. China."
},
{
"LastName": "Zhang",
"FirstName": "Kai",
"Affiliation": "State Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, 130012, P. R. China."
},
{
"LastName": "Yang",
"FirstName": "Bai",
"Affiliation": "State Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, 130012, P. R. China."
}
] |
No
|
38976695
|
Ecological assessment of water quality in freshwater wetlands based on the effect of environmental heterogeneity on phytoplankton communities in Northeast China.
|
Phytoplankton community characterized by strong vitality response to environmental change in freshwater ecosystems. This study aims to evaluate the effectiveness of using phytoplankton diversity as a water quality indicator in wetlands, and find out the main environmental variables affecting the distribution of phytoplankton. From 2020 to 2021, we examined phytoplankton assemblages and water environmental variables in spring, summer, and autumn at eight sampling sites from Hulanhe Wetland, Northeast (NE) China. The results showed that Bacillariophyta was the dominant species. Phytoplankton composition and abundance differed among sampling sites in each season; the abundance in summer (613.71 × 104 ind. L-1) was higher than that in autumn and spring. The water quality assessment of the trophic state index (TSI) based on the four physicochemical indicators was compared with phytoplankton diversity indices, which indicated that the phytoplankton community was stable, and these two indices were significantly lower in summer than in spring and autumn. According to redundancy analysis (RDA), total phosphorus (TP) and nitrogen (TN) were the main environmental variables affecting the distribution of phytoplankton. Temperature and dissolved oxygen (DO) changes also played a role, and their impact on the community was discussed. This work can provide relevant scientific references on the usefulness of phytoplankton diversity structure in assessing water quality in cold regions, in which the succession can be significantly affected by nutrients and temperatures.
|
2024
|
PloS one
|
No DOI
|
[
{
"LastName": "Hui",
"FirstName": "Hongkuan",
"Affiliation": "School of Geography and Tourism, Qilu Normal University, Jinan, China."
},
{
"LastName": "Liu",
"FirstName": "Xiao",
"Affiliation": "School of Geography and Tourism, Qilu Normal University, Jinan, China."
},
{
"LastName": "Wei",
"FirstName": "Yinxin",
"Affiliation": "Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China."
},
{
"LastName": "Su",
"FirstName": "Dan",
"Affiliation": "Heilongjiang Province Key Laboratory of Geographical Environment Monitoring and Spatial Information Service in Cold Regions, Harbin Normal University, Harbin, China."
},
{
"LastName": "Zhou",
"FirstName": "Haitao",
"Affiliation": "Heilongjiang Province Key Laboratory of Geographical Environment Monitoring and Spatial Information Service in Cold Regions, Harbin Normal University, Harbin, China."
},
{
"LastName": "Peng",
"FirstName": "Zirui",
"Affiliation": "School of Geography and Tourism, Qilu Normal University, Jinan, China."
}
] |
No
|
39036232
|
Management of a Large Cerebral Abscess in Children Caused by Campylobacter gracilis: A Case Report and Review of the Literature.
|
Campylobacter gracilis inhabits the gingival sulcus and has been reported to cause various periodontal diseases; it has rarely been reported to cause bacteremia. We describe a case of a two-year-old boy who presented with a consciousness disorder and was transferred to our hospital for treatment of a brain abscess. Magnetic resonance imaging (MRI) showed a 6-cm brain abscess in the right frontal lobe. Urgent drainage and antibiotic administration resulted in a favorable clinical course, and the patient was discharged on the 34th day of hospitalization. Streptococcus anginosus and C. gracilis were identified in the pus. Brain abscesses caused by C. gracilis have rarely been reported, which makes this a valuable case.
|
2024 Jun
|
Cureus
|
No DOI
|
[
{
"LastName": "Arakawa",
"FirstName": "Yu",
"Affiliation": "Department of Clinial Infectious Diseases, Kōchi Medical School Hospital, Kōchi University, Nankoku City, JPN."
},
{
"LastName": "Yagi",
"FirstName": "Yusuke",
"Affiliation": "Divison of Infection and Prevention, Kōchi Medical School Hospital, Nankoku City, JPN."
},
{
"LastName": "Mimoto",
"FirstName": "Airi",
"Affiliation": "Department of Clinical laboratory, Kōchi Medical School Hospital, Nankoku City, JPN."
},
{
"LastName": "Nishida",
"FirstName": "Yoshie",
"Affiliation": "Department of Clinical laboratory, Kōchi Medical School Hospital, Nankoku City, JPN."
},
{
"LastName": "Kuwana",
"FirstName": "Shunsuke",
"Affiliation": "Department of Pediatrics, Kōchi Medical School, Kōchi University, Nankoku City, JPN."
},
{
"LastName": "Nakai",
"FirstName": "Eiichi",
"Affiliation": "Department of Neurosurgery, Kōchi Medical School, Kōchi University, Nankoku City, JPN."
},
{
"LastName": "Ueba",
"FirstName": "Tetsuya",
"Affiliation": "Department of Neurosurgery, Kōchi Medical School, Kōchi University, Nankoku City, JPN."
},
{
"LastName": "Fujieda",
"FirstName": "Mikiya",
"Affiliation": "Department of Pediatrics, Kōchi Medical School, Kōchi University, Nankoku City, JPN."
},
{
"LastName": "Yamagishi",
"FirstName": "Yuka",
"Affiliation": "Department of Clinical Infectious Diseases, Kōchi Medical School Hospital, Kōchi University, Nankoku City, JPN."
}
] |
No
|
11132748
|
Different effects of olprinone on contractility in nonfatigued and fatigued diaphragm in dogs.
|
To evaluate the effects of low-dose olprinone, a phosphodiesterase III inhibitor, on contractility and its mechanism in nonfatigued and fatigued diaphragm in dogs. Thirty six pentobarbitone-anesthetized dogs were studied. In Group Ia (n=6), animals without fatigue, received no study drug. In Group Ib (n=6), dogs were given a bolus injection (10 ug x kg(-1)) followed by continuous infusion (0.1 microg x kg(-1) x min(-1)) of olprinone. In Groups IIa, IIb, and IIc (n=8 each), diaphragmatic fatigue was induced by intermittent supramaximal bilateral electrophrenic stimulation at a frequency of 20-Hz applied for 30 min. After producing fatigue, Group IIa received no study drug; Group IIb was infused with olprinone (10 ug x kg(-1) loading dose plus 0.1 microg-kg(-1) min(-1) maintenance dose); Group IIc was infused with nicardipine (5 microg x kg(-1) x min(-1)) during olprinone administration. Diaphragmatic contractility was assessed by transdiaphragmatic pressure (Pdi). No difference in Pdi was observed between Groups Ia and Ib. After fatigue, in Groups IIa, IIb, and IIc, Pdi at low-frequency (20-Hz) stimulation decreased from prefatigued (baseline) values (P < 0.05), whereas there was no change in Pdi at high-frequency stimulation (100-Hz). In Group IIb, during olprinone administration, Pdi at both stimuli increased from fatigued values (P < 0.05). In Group IIc, the augmentation of Pdi to each stimulus in fatigued diaphragm by olprinone was abolished with an infusion of nicardipine. Low-dose olprinone does not affect contractility in nonfatigued diaphragm, but increases contractility in fatigued diaphragm via its effect on transmembrane calcium movement in dogs.
|
2000 Dec
|
Canadian journal of anaesthesia = Journal canadien d'anesthesie
|
No DOI
|
[
{
"LastName": "Fujii",
"FirstName": "Y",
"Affiliation": "Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan. [email protected]"
},
{
"LastName": "Toyooka",
"FirstName": "H",
"Affiliation": ""
}
] |
Yes
|
38008729
|
A landscape on disorders following different COVID-19 vaccination: a systematic review of Iranian case reports.
|
There have been massive studies to develop an effective vaccine against SARS-CoV-2 which fortunately led to manage the recent pandemic, COVID-19. According to the quite rapidly developed vaccines in a fast window time, large investigations to assess the probable vaccine-related adverse events are crucially required. COVID-19 vaccines are available of different platforms and the primary clinical trials results presented acceptable safety profile of the approved vaccines. Nevertheless, the long-term assessment of the adverse events or rare conditions need to be investigated. The present systematic review, aimed at classification of probable vaccine-related unsolicited adverse events in Iranian population through the data collection of the published case report studies.The related published case reports were explored via PubMed, Web of Science and Google scholar according to the available published data up to 14[th] Dec, 2022 using PRISMA guideline. Out of 437 explored studies, the relevant data were fully investigated which totally led to 40 studies, including 64 case reports with a new onset of a problem post-vaccination. The cases were then classified according to the various items, such as the type of adverse event and COVID-19 vaccines.The reported COVID-19 vaccines in the studied cases included BBIBP-CorV, ChAdOx1-S, Sputnik V and COVAXIN. The results showed that the adverse events presented in 8 different categories, including cutaneous involvements in 43.7% (n = 28), neurologic problems (n = 16), blood/vessel involvement (n = 6), cardiovascular involvement (n = 5), ocular disorders (n = 4), liver disorder/failure (n = 2), graft rejection (n = 2) and one metabolic disorder. Notably, almost 60% of the cases had no comorbidities. Moreover, the obtained data revealed nearly half of the incidences occurred after the first dose of injection and the median duration of improvement after the symptom was 10 days (range: 2-120). In addition, 73% of all the cases were either significantly improved or fully recovered. Liver failure following ChAdOx1-S vaccination was the most serious vaccine adverse event which led to death in two individuals with no related medical history.Although the advantages of COVID-19 vaccination is undoubtedly significant, individuals including with a history of serious disease, comorbidities and immunodeficiency conditions should be vaccinated with the utmost caution. This study provides a comprehensive overview and clinical implications of possible vaccine-related adverse events which should be considered in further vaccination strategies. Nevertheless, there might be a bias regarding potential under-reporting and missing data of the case reports included in the present study. Although the reported data are not proven to be the direct vaccination outcomes and could be a possible immune response over stimulation, the people the population with a medium/high risk should be monitored after getting vaccinated against COVID-19 of any platforms. This could be achieved by a carefull attention to the subjects ' medical history and also through consulting with healthcare providers before vaccination.
|
2023 Nov 26
|
European journal of medical research
|
No DOI
|
[
{
"LastName": "Sadat Larijani",
"FirstName": "Mona",
"Affiliation": "Clinical Research Department, Pasteur Institute of Iran, No: 69, Pasteur Ave, Tehran, 1316943551, Iran."
},
{
"LastName": "Doroud",
"FirstName": "Delaram",
"Affiliation": "Quality Control Department, Production and Research Complex, Pasteur Institute of Iran, Tehran, Iran."
},
{
"LastName": "Banifazl",
"FirstName": "Mohammad",
"Affiliation": "Iranian Society for Support of Patients With Infectious Disease, Tehran, Iran."
},
{
"LastName": "Karami",
"FirstName": "Afsaneh",
"Affiliation": "Department of Infectious Disease, Zanjan University of Medical Sciences, Zanjan, Iran."
},
{
"LastName": "Bavand",
"FirstName": "Anahita",
"Affiliation": "Clinical Research Department, Pasteur Institute of Iran, No: 69, Pasteur Ave, Tehran, 1316943551, Iran."
},
{
"LastName": "Ashrafian",
"FirstName": "Fatemeh",
"Affiliation": "Clinical Research Department, Pasteur Institute of Iran, No: 69, Pasteur Ave, Tehran, 1316943551, Iran."
},
{
"LastName": "Ramezani",
"FirstName": "Amitis",
"Affiliation": "Clinical Research Department, Pasteur Institute of Iran, No: 69, Pasteur Ave, Tehran, 1316943551, Iran. [email protected]."
}
] |
No
|
35242044
|
Diabetes Mellitus and Heart Failure With Preserved Ejection Fraction: Role of Obesity.
|
Heart failure with preserved ejection fraction is a growing epidemic and accounts for half of all patients with heart failure. Increasing prevalence, morbidity, and clinical inertia have spurred a rethinking of the pathophysiology of heart failure with preserved ejection fraction. Unlike heart failure with reduced ejection fraction, heart failure with preserved ejection fraction has distinct clinical phenotypes. The obese-diabetic phenotype is the most often encountered phenotype in clinical practice and shares the greatest burden of morbidity and mortality. Left ventricular remodeling plays a major role in its pathophysiology. Understanding the interplay of obesity, diabetes mellitus, and inflammation in the pathophysiology of left ventricular remodeling may help in the discovery of new therapeutic targets to improve clinical outcomes in heart failure with preserved ejection fraction. Anti-diabetic agents like glucagon-like-peptide 1 analogs and sodium-glucose co-transporter 2 are promising therapeutic modalities for the obese-diabetic phenotype of heart failure with preserved ejection fraction and aggressive weight loss via lifestyle or bariatric surgery is still key to reverse adverse left ventricular remodeling. This review focuses on the obese-diabetic phenotype of heart failure with preserved ejection fraction highlighting the interaction between obesity, diabetes, and coronary microvascular dysfunction in the development and progression of left ventricular remodeling. Recent therapeutic advances are reviewed.
|
2021
|
Frontiers in physiology
|
No DOI
|
[
{
"LastName": "Dhore-Patil",
"FirstName": "Aneesh",
"Affiliation": "Section of Cardiology, Department of Medicine, Tulane University School of Medicine, New Orleans, LA, United States."
},
{
"LastName": "Thannoun",
"FirstName": "Tariq",
"Affiliation": "Section of Cardiology, Department of Medicine, Tulane University School of Medicine, New Orleans, LA, United States."
},
{
"LastName": "Samson",
"FirstName": "Rohan",
"Affiliation": "Section of Cardiology, Department of Medicine, Tulane University School of Medicine, New Orleans, LA, United States."
},
{
"LastName": "Le Jemtel",
"FirstName": "Thierry H",
"Affiliation": "Section of Cardiology, Department of Medicine, Tulane University School of Medicine, New Orleans, LA, United States."
}
] |
No
|
38099949
|
Analysis of Perioperative and Long-Term Outcomes Among Presentations of Anomalous Left Coronary Artery from the Pulmonary Artery Diagnosed Beyond Infancy Versus During Infancy.
|
Anomalous Left Coronary Artery from the Pulmonary Artery (ALCAPA) typically presents in infancy; however, there are cases of patients who survive the infant period and present later in life. We aimed to characterize patients with late ALCAPA diagnoses and to assess perioperative and functional outcomes. A retrospective chart review of patients who underwent ALCAPA repair between 1996 and 2020 at Boston Children's Hospital was performed. This cohort was divided into early ALCAPA (< 1 year) and late ALCAPA (≥ 1 year) groups. Perioperative data were collected. Longitudinal functional assessments were made by echocardiography, exercise stress test, and cardiac magnetic resonance imaging. The median age of the late ALCAPA group was 7.6 years with 25% (6/24) of patients over 18 years. The late ALCAPA group was more likely to present as an incidental finding (63%) and required less preoperative intervention compared to the early group. On preoperative echocardiogram, the late ALCAPA group had less moderate or severe mitral regurgitation (16.7% vs 62%, p < 0.001) or left ventricular dysfunction (16.7% vs 89%, p < 0.001) compared to the early group. Reoperation was uncommon, and both groups demonstrated almost complete resolution of mitral regurgitation and left ventricular dysfunction over time. There are important differences between late and early ALCAPA subtypes. Revascularization results in excellent outcomes in both early and late groups, but long-term surveillance of ALCAPA patients is warranted as they may have functional deficits after repair.
|
2023 Dec 15
|
Pediatric cardiology
|
No DOI
|
[
{
"LastName": "Straka",
"FirstName": "Nadine",
"Affiliation": "Department of Pain, Critical Care, and Anesthesia, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA. [email protected]."
},
{
"LastName": "Gauvreau",
"FirstName": "Kimberlee",
"Affiliation": "Department of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA."
},
{
"LastName": "Huang",
"FirstName": "Yisong",
"Affiliation": "Department of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA."
},
{
"LastName": "DeWitt",
"FirstName": "Elizabeth",
"Affiliation": "Department of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA."
},
{
"LastName": "Allan",
"FirstName": "Catherine",
"Affiliation": "Department of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA."
},
{
"LastName": "Thiagarajan",
"FirstName": "Ravi",
"Affiliation": "Department of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA."
},
{
"LastName": "Nathan",
"FirstName": "Meena",
"Affiliation": "Department of Cardiac Surgery, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA."
}
] |
No
|
33676312
|
Promotion of tomato growth by the volatiles produced by the hypovirulent strain QT5-19 of the plant gray mold fungus Botrytis cinerea.
|
Our previous study identified a hypovirulent strain QT5-19 of Botrytis cinerea, the causal agent of the plant gray mold disease, and found that QT5-19 can produce volatile organic compounds (VOCs) with high antifungal activity and high control efficacy against B. cinerea. However, impact of the QT5-19 VOCs on plant growth remains unknown. This study was conducted to investigate the impact of the QT5-19 VOCs on tomato growth, and to elucidate the mechanisms for the plant growth-promoting (PGP) activity of the QT5-19 VOCs. Results showed that compared to the control treatment, the QT5-19 VOCs significantly (P < 0.05) promoted tomato growth, and the PGP activity of the QT5-19 VOCs acted in dose- and time-dependent manners. Results also showed that the values of photosynthetic assimilation, stomatal conductance and transpiration, water use efficiency and chlorophyll content in the treatments of the QT5-19 VOCs were significantly (P < 0.05) higher than the corresponding values in the control treatment. The QT5-19 VOCs up-regulated expression of the genes for expansins (EXP2, EXP9 and EXP18), IAA (SlIAA1, SlIAA3 and SlIAA9), cytokinins (SlCKX1) and gibberellins in leaves and/or roots, whereas down-regulated expression of the gene ACO1 for ethylene in both organs. Moreover, enhanced accumulation of auxins and decreased accumulation of ethylene were observed in tomato roots in the treatment of the QT5-19 VOCs, compared to the control treatment. These results suggest that the QT5-19 VOCs probably promote tomato growth through improving photosynthesis and biosynthesis of expansins and IAA, and reducing ethylene biosynthesis. This study suggests that QT5-19 is a versatile biocontrol control agent.
|
2021 Jun
|
Microbiological research
|
No DOI
|
[
{
"LastName": "Kamaruzzaman",
"FirstName": "Md",
"Affiliation": "State Key Laboratory of Agricultural Microbiology and Key Laboratory of Plant Pathology of Hubei Province, Huazhong Agricultural University, Wuhan, 430070, Hubei, China."
},
{
"LastName": "Wang",
"FirstName": "Ze",
"Affiliation": "State Key Laboratory of Agricultural Microbiology and Key Laboratory of Plant Pathology of Hubei Province, Huazhong Agricultural University, Wuhan, 430070, Hubei, China."
},
{
"LastName": "Wu",
"FirstName": "Mingde",
"Affiliation": "State Key Laboratory of Agricultural Microbiology and Key Laboratory of Plant Pathology of Hubei Province, Huazhong Agricultural University, Wuhan, 430070, Hubei, China."
},
{
"LastName": "Yang",
"FirstName": "Long",
"Affiliation": "State Key Laboratory of Agricultural Microbiology and Key Laboratory of Plant Pathology of Hubei Province, Huazhong Agricultural University, Wuhan, 430070, Hubei, China."
},
{
"LastName": "Han",
"FirstName": "Yongchao",
"Affiliation": "Institute of Industrial Crops, Hubei Academy of Agricultural Science, Wuhan, 430070, Hubei, China."
},
{
"LastName": "Li",
"FirstName": "Guoqing",
"Affiliation": "State Key Laboratory of Agricultural Microbiology and Key Laboratory of Plant Pathology of Hubei Province, Huazhong Agricultural University, Wuhan, 430070, Hubei, China."
},
{
"LastName": "Zhang",
"FirstName": "Jing",
"Affiliation": "State Key Laboratory of Agricultural Microbiology and Key Laboratory of Plant Pathology of Hubei Province, Huazhong Agricultural University, Wuhan, 430070, Hubei, China. Electronic address: [email protected]."
}
] |
No
|
18947645
|
Hazard of botulinum toxin type A injection into the detrusor in patients with an artificial urinary sphincter.
|
We performed a retrospective chart review of two patients with a previously implanted artificial urinary sphincter (AUS) who became incontinent after the injection of botulinum toxin type A into the detrusor. Two prepubertal males with a myelomeningocele, neuropathic bladder and urinary incontinence developed bladder hypertonicity. Treatment by botulinum toxin type A injection into the detrusor resulted in a loss of fluid from the balloon and recurrent incontinence. This method of treatment in patients with a previously implanted AUS should be avoided, as not only does it appear to be of only temporary benefit, but also as demonstrated by these cases it can damage the AUS system.
|
2006 Oct
|
Journal of pediatric urology
|
No DOI
|
[
{
"LastName": "Mazzone",
"FirstName": "Luca",
"Affiliation": "Department of Paediatric Surgery, Kinderspital Universität Zürich, Kinderchirurgie, Steinwiesstrasse 75, 8032 Zürich, Switzerland."
},
{
"LastName": "Weber",
"FirstName": "Daniel",
"Affiliation": ""
},
{
"LastName": "van der Hoeff",
"FirstName": "Marianne",
"Affiliation": ""
},
{
"LastName": "Gobet",
"FirstName": "Rita",
"Affiliation": ""
},
{
"LastName": "González",
"FirstName": "Ricardo",
"Affiliation": ""
}
] |
No
|
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