Datasets:
clinicalnlplab
/
BC5CDR_chemical_train

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In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: We therefore sought to determine the prevalence and clinical associations of hyperkalemia and renal insufficiency in heart failure patients treated with spironolactone . ### Output Text:
We therefore sought to determine the prevalence and clinical associations of hyperkalemia and renal insufficiency in heart failure patients treated with <span class="chemical">spironolactone</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: METHODS : We performed a case control study of heart failure patients treated with spironolactone in our clinical practice . ### Output Text:
METHODS : We performed a case control study of heart failure patients treated with <span class="chemical">spironolactone</span> in our clinical practice .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Cases were patients who developed hyperkalemia ( K ( + ) > 5 . 0 mEq / L ) or renal insufficiency ( Cr > or = 2 . 5 mg / dL ) , and they were compared to 2 randomly selected controls per case . ### Output Text:
Cases were patients who developed hyperkalemia ( <span class="chemical">K</span> ( + ) > 5 . 0 mEq / L ) or renal insufficiency ( <span class="chemical">Cr</span> > or = 2 . 5 mg / dL ) , and they were compared to 2 randomly selected controls per case .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Clinical characteristics , medications , and serum chemistries at baseline and follow - up time periods were compared . ### Output Text:
Clinical characteristics , medications , and serum chemistries at baseline and follow - up time periods were compared .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: RESULTS : Sixty - seven of 926 patients ( 7 . 2 % ) required discontinuation of spironolactone due to hyperkalemia ( n = 33 ) or renal failure ( n = 34 ) . ### Output Text:
RESULTS : Sixty - seven of 926 patients ( 7 . 2 % ) required discontinuation of <span class="chemical">spironolactone</span> due to hyperkalemia ( n = 33 ) or renal failure ( n = 34 ) .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Patients who developed hyperkalemia were older and more likely to have diabetes , had higher baseline serum potassium levels and lower baseline potassium supplement doses , and were more likely to be treated with beta - blockers than controls ( n = 134 ) . ### Output Text:
Patients who developed hyperkalemia were older and more likely to have diabetes , had higher baseline serum <span class="chemical">potassium</span> levels and lower baseline <span class="chemical">potassium</span> supplement doses , and were more likely to be treated with beta - blockers than controls ( n = 134 ) .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Patients who developed renal insufficiency had lower baseline body weight and higher baseline serum creatinine , required higher doses of loop diuretics , and were more likely to be treated with thiazide diuretics than controls . ### Output Text:
Patients who developed renal insufficiency had lower baseline body weight and higher baseline serum <span class="chemical">creatinine</span> , required higher doses of loop diuretics , and were more likely to be treated with <span class="chemical">thiazide</span> diuretics than controls .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: CONCLUSIONS : Spironolactone - induced hyperkalemia and renal insufficiency are more common in our clinical experience than reported previously . ### Output Text:
CONCLUSIONS : <span class="chemical">Spironolactone</span> - induced hyperkalemia and renal insufficiency are more common in our clinical experience than reported previously .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: This difference is explained by patient comorbidities and more frequent use of beta - blockers . ### Output Text:
This difference is explained by patient comorbidities and more frequent use of beta - blockers .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Acute reserpine and subchronic haloperidol treatments change synaptosomal brain glutamate uptake and elicit orofacial dyskinesia in rats . ### Output Text:
Acute <span class="chemical">reserpine</span> and subchronic <span class="chemical">haloperidol</span> treatments change synaptosomal brain <span class="chemical">glutamate</span> uptake and elicit orofacial dyskinesia in rats .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Reserpine - and haloperidol - induced orofacial dyskinesia are putative animal models of tardive dyskinesia ( TD ) whose pathophysiology has been related to free radical generation and oxidative stress . ### Output Text:
<span class="chemical">Reserpine</span> - and <span class="chemical">haloperidol</span> - induced orofacial dyskinesia are putative animal models of tardive dyskinesia ( TD ) whose pathophysiology has been related to free radical generation and oxidative stress .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: In the present study , the authors induced orofacial dyskinesia by acute reserpine and subchronic haloperidol administration to rats . ### Output Text:
In the present study , the authors induced orofacial dyskinesia by acute <span class="chemical">reserpine</span> and subchronic <span class="chemical">haloperidol</span> administration to rats .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Reserpine injection ( one dose of 1 mg / kg s . c . ) every other day for 3 days caused a significant increase in vacuous chewing , tongue protrusion and duration of facial twitching , compared to the control . ### Output Text:
<span class="chemical">Reserpine</span> injection ( one dose of 1 mg / kg s . c . ) every other day for 3 days caused a significant increase in vacuous chewing , tongue protrusion and duration of facial twitching , compared to the control .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Haloperidol administration ( one dose of 12 mg / kg once a week s . c . ) for 4 weeks caused an increase in vacuous chewing , tongue protrusion and duration of facial twitching observed in four weekly evaluations . ### Output Text:
<span class="chemical">Haloperidol</span> administration ( one dose of 12 mg / kg once a week s . c . ) for 4 weeks caused an increase in vacuous chewing , tongue protrusion and duration of facial twitching observed in four weekly evaluations .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: After the treatments and behavioral observation , glutamate uptake by segments of the brain was analyzed . ### Output Text:
After the treatments and behavioral observation , <span class="chemical">glutamate</span> uptake by segments of the brain was analyzed .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: A decreased glutamate uptake was observed in the subcortical parts of animals treated with reserpine and haloperidol , compared to the control . ### Output Text:
A decreased <span class="chemical">glutamate</span> uptake was observed in the subcortical parts of animals treated with <span class="chemical">reserpine</span> and <span class="chemical">haloperidol</span> , compared to the control .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Importantly , a decrease in glutamate uptake correlates negatively with an increase in the incidence of orofacial diskinesia . ### Output Text:
Importantly , a decrease in <span class="chemical">glutamate</span> uptake correlates negatively with an increase in the incidence of orofacial diskinesia .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: These results indicate that early changes in glutamate transport may be related to the development of vacuous chewing movements in rats . ### Output Text:
These results indicate that early changes in <span class="chemical">glutamate</span> transport may be related to the development of vacuous chewing movements in rats .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Ceftriaxone - associated biliary pseudolithiasis in paediatric surgical patients . ### Output Text:
<span class="chemical">Ceftriaxone</span> - associated biliary pseudolithiasis in paediatric surgical patients .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: It is well known that ceftriaxone leads to pseudolithiasis in some patients . ### Output Text:
It is well known that <span class="chemical">ceftriaxone</span> leads to pseudolithiasis in some patients .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Clinical and experimental studies also suggest that situations causing gallbladder dysfunction , such as fasting , may have a role for the development of pseudolithiasis . ### Output Text:
Clinical and experimental studies also suggest that situations causing gallbladder dysfunction , such as fasting , may have a role for the development of pseudolithiasis .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: In this study , we prospectively evaluated the incidence and clinical importance of pseudolithiasis in paediatric surgical patients receiving ceftriaxone treatment , who often had to fast in the post - operative period . ### Output Text:
In this study , we prospectively evaluated the incidence and clinical importance of pseudolithiasis in paediatric surgical patients receiving <span class="chemical">ceftriaxone</span> treatment , who often had to fast in the post - operative period .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Fifty children who were given ceftriaxone were evaluated by serial abdominal sonograms . ### Output Text:
Fifty children who were given <span class="chemical">ceftriaxone</span> were evaluated by serial abdominal sonograms .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Of those , 13 ( 26 % ) developed biliary pathology . ### Output Text:
Of those , 13 ( 26 % ) developed biliary pathology .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Comparison of the patients with or without pseudolithiasis revealed no significant difference with respect to age , sex , duration of the treatment and starvation variables . ### Output Text:
Comparison of the patients with or without pseudolithiasis revealed no significant difference with respect to age , sex , duration of the treatment and starvation variables .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: After cessation of the treatment , pseudolithiasis resolved spontaneously within a short period . ### Output Text:
After cessation of the treatment , pseudolithiasis resolved spontaneously within a short period .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The incidence of pseudolithiasis is not affected by fasting . ### Output Text:
The incidence of pseudolithiasis is not affected by fasting .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Coronary aneurysm after implantation of a paclitaxel - eluting stent . ### Output Text:
Coronary aneurysm after implantation of a <span class="chemical">paclitaxel</span> - eluting stent .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Formation of coronary aneurysm is a rare complication of stenting with bare metal stents , but based on experimental studies drug - eluting stents may induce toxic effects on the vessel wall with incomplete stent apposition , aneurysm formation and with the potential of stent thrombosis or vessel rupture . ### Output Text:
Formation of coronary aneurysm is a rare complication of stenting with bare metal stents , but based on experimental studies drug - eluting stents may induce toxic effects on the vessel wall with incomplete stent apposition , aneurysm formation and with the potential of stent thrombosis or vessel rupture .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: We present a 43 - year - old man who developed a coronary aneurysm in the right coronary artery 6 months after receiving a paclitaxel - eluting stent . ### Output Text:
We present a 43 - year - old man who developed a coronary aneurysm in the right coronary artery 6 months after receiving a <span class="chemical">paclitaxel</span> - eluting stent .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The patient was asymptomatic and the aneurysm was detected in a routine control . ### Output Text:
The patient was asymptomatic and the aneurysm was detected in a routine control .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Angiography and intracoronary ultrasound demonstrated lack of contact between stent and vessel wall in a 15 - mm long segment with maximal aneurysm diameter of 6 . 0 mm . ### Output Text:
Angiography and intracoronary ultrasound demonstrated lack of contact between stent and vessel wall in a 15 - mm long segment with maximal aneurysm diameter of 6 . 0 mm .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The patient was successfully treated with a graft stent . ### Output Text:
The patient was successfully treated with a graft stent .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Causes of acute thrombotic microangiopathy in patients receiving kidney transplantation . ### Output Text:
Causes of acute thrombotic microangiopathy in patients receiving kidney transplantation .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: OBJECTIVES : Thrombotic microangiopathy is a well - known problem in patients following renal transplantation . ### Output Text:
OBJECTIVES : Thrombotic microangiopathy is a well - known problem in patients following renal transplantation .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: In postrenal transplantation , thrombotic microangiopathy is often a reflection of hemolytic uremic syndrome . ### Output Text:
In postrenal transplantation , thrombotic microangiopathy is often a reflection of hemolytic uremic syndrome .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: We aimed to determine the causes of thrombotic microangiopathy in a population of renal transplantation recipients and discuss the literature . ### Output Text:
We aimed to determine the causes of thrombotic microangiopathy in a population of renal transplantation recipients and discuss the literature .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: MATERIALS AND METHODS : We investigated the causes of thrombotic microangiopathy during a 1 - year period , from June 2003 to June 2004 , at the King Fahad National Guard Hospital in Riyadh , Saudi Arabia , by reviewing the slides of all transplant biopsies ( n = 25 ) performed during this interval . ### Output Text:
MATERIALS AND METHODS : We investigated the causes of thrombotic microangiopathy during a 1 - year period , from June 2003 to June 2004 , at the King Fahad National Guard Hospital in Riyadh , Saudi Arabia , by reviewing the slides of all transplant biopsies ( n = 25 ) performed during this interval .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Pre - and posttransplant crossmatching was done when possible . ### Output Text:
Pre - and posttransplant crossmatching was done when possible .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: RESULTS : Five cases of thrombotic microangiopathy were found . ### Output Text:
RESULTS : Five cases of thrombotic microangiopathy were found .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Three of these cases were from the 25 transplantations performed at King Fahad National Guard Hospital , while the other 2 transplantations had been performed abroad and were referred to us for follow - up . ### Output Text:
Three of these cases were from the 25 transplantations performed at King Fahad National Guard Hospital , while the other 2 transplantations had been performed abroad and were referred to us for follow - up .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Three cases were related to cyclosporine , and 1 case was secondary to both cyclosporine and tacrolimus . ### Output Text:
Three cases were related to <span class="chemical">cyclosporine</span> , and 1 case was secondary to both <span class="chemical">cyclosporine</span> and <span class="chemical">tacrolimus</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The fifth case had features of thrombotic microangiopathy related to an antiphospholipid syndrome in a patient with systemic lupus erythematosus . ### Output Text:
The fifth case had features of thrombotic microangiopathy related to an antiphospholipid syndrome in a patient with systemic lupus erythematosus .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: CONCLUSIONS : In the literature , the most - frequent cause of hemolytic uremic syndrome in patients following renal transplantation is recurrence of the hemolytic uremic syndrome . ### Output Text:
CONCLUSIONS : In the literature , the most - frequent cause of hemolytic uremic syndrome in patients following renal transplantation is recurrence of the hemolytic uremic syndrome .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Other causes include drug - related ( cyclosporine , tacrolimus ) toxicity , procoagulant status , and antibody - mediated rejection . ### Output Text:
Other causes include drug - related ( <span class="chemical">cyclosporine</span> , <span class="chemical">tacrolimus</span> ) toxicity , procoagulant status , and antibody - mediated rejection .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: We found that the most - frequent cause of thrombotic microangiopathy was drug related , secondary mainly to cyclosporine . ### Output Text:
We found that the most - frequent cause of thrombotic microangiopathy was drug related , secondary mainly to <span class="chemical">cyclosporine</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: In the current study , the frequency of thrombotic microangiopathy was similar to the percentage reported in the literature ( 20 % ) . ### Output Text:
In the current study , the frequency of thrombotic microangiopathy was similar to the percentage reported in the literature ( 20 % ) .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Comparison of developmental toxicity of selective and non - selective cyclooxygenase - 2 inhibitors in CRL : ( WI ) WUBR Wistar rats - - DFU and piroxicam study . ### Output Text:
Comparison of developmental toxicity of selective and non - selective cyclooxygenase - 2 inhibitors in CRL : ( WI ) WUBR Wistar rats - - <span class="chemical">DFU</span> and <span class="chemical">piroxicam</span> study .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: BACKGROUND : Cyclooxygenase ( COX ) inhibitors are one of the most often ingested drugs during pregnancy . ### Output Text:
BACKGROUND : Cyclooxygenase ( COX ) inhibitors are one of the most often ingested drugs during pregnancy .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Unlike general toxicity data , their prenatal toxic effects were not extensively studied before . ### Output Text:
Unlike general toxicity data , their prenatal toxic effects were not extensively studied before .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The aim of the experiment was to evaluate the developmental toxicity of the non - selective ( piroxicam ) and selective ( DFU ; 5 , 5 - dimethyl - 3 - ( 3 - fluorophenyl ) - 4 - ( 4 - methylsulphonyl ) phenyl - 2 ( 5H ) - furanon ) COX - 2 inhibitors . ### Output Text:
The aim of the experiment was to evaluate the developmental toxicity of the non - selective ( <span class="chemical">piroxicam</span> ) and selective ( <span class="chemical">DFU</span> ; <span class="chemical">5 , 5 - dimethyl - 3 - ( 3 - fluorophenyl ) - 4 - ( 4 - methylsulphonyl ) phenyl - 2 ( 5H ) - furanon</span> ) COX - 2 inhibitors .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: METHODS : Drugs were separately , orally once daily dosed to pregnant rats from day 8 to 21 ( GD1 = plug day ) . ### Output Text:
METHODS : Drugs were separately , orally once daily dosed to pregnant rats from day 8 to 21 ( GD1 = plug day ) .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Doses were set at 0 . 3 , 3 . 0 and 30 . 0mg / kg for piroxicam and 0 . 2 , 2 . 0 and 20 . 0mg / kg for DFU . ### Output Text:
Doses were set at 0 . 3 , 3 . 0 and 30 . 0mg / kg for <span class="chemical">piroxicam</span> and 0 . 2 , 2 . 0 and 20 . 0mg / kg for <span class="chemical">DFU</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Fetuses were delivered on GD 21 and routinely examined . ### Output Text:
Fetuses were delivered on GD 21 and routinely examined .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Comprehensive clinical and developmental measurements were done . ### Output Text:
Comprehensive clinical and developmental measurements were done .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The pooled statistical analysis for ventricular septal ( VSD ) and midline ( MD ) defects was performed for rat fetuses exposed to piroxicam , selective and non - selective COX - 2 inhibitor based on present and historic data . ### Output Text:
The pooled statistical analysis for ventricular septal ( VSD ) and midline ( MD ) defects was performed for rat fetuses exposed to <span class="chemical">piroxicam</span> , selective and non - selective COX - 2 inhibitor based on present and historic data .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: RESULTS : Maternal toxicity , intrauterine growth retardation , and increase of external and skeletal variations were found in rats treated with the highest dose of piroxicam . ### Output Text:
RESULTS : Maternal toxicity , intrauterine growth retardation , and increase of external and skeletal variations were found in rats treated with the highest dose of <span class="chemical">piroxicam</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Decrease of fetal length was the only signs of the DFU developmental toxicity observed in pups exposed to the highest compound dose . ### Output Text:
Decrease of fetal length was the only signs of the <span class="chemical">DFU</span> developmental toxicity observed in pups exposed to the highest compound dose .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Lack of teratogenicity was found in piroxicam and DFU - exposed groups . ### Output Text:
Lack of teratogenicity was found in <span class="chemical">piroxicam</span> and <span class="chemical">DFU</span> - exposed groups .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Prenatal exposure to non - selective COX inhibitors increases the risk of VSD and MD when compared to historic control but not with selective COX - 2 inhibitors . ### Output Text:
Prenatal exposure to non - selective COX inhibitors increases the risk of VSD and MD when compared to historic control but not with selective COX - 2 inhibitors .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: CONCLUSION : Both selective and non - selective COX - 2 inhibitors were toxic for rats fetuses when administered in the highest dose . ### Output Text:
CONCLUSION : Both selective and non - selective COX - 2 inhibitors were toxic for rats fetuses when administered in the highest dose .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Unlike DFU , piroxicam was also highly toxic to the dams . ### Output Text:
Unlike <span class="chemical">DFU</span> , <span class="chemical">piroxicam</span> was also highly toxic to the dams .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Prenatal exposure to selective COX - 2 inhibitors does not increase the risk of ventricular septal and midline defects in rat when compared to non - selective drugs and historic control . ### Output Text:
Prenatal exposure to selective COX - 2 inhibitors does not increase the risk of ventricular septal and midline defects in rat when compared to non - selective drugs and historic control .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Lone atrial fibrillation associated with creatine monohydrate supplementation . ### Output Text:
Lone atrial fibrillation associated with <span class="chemical">creatine</span> monohydrate supplementation .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Atrial fibrillation in young patients without structural heart disease is rare . ### Output Text:
Atrial fibrillation in young patients without structural heart disease is rare .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Therefore , when the arrhythmia is present in this population , reversible causes must be identified and resolved . ### Output Text:
Therefore , when the arrhythmia is present in this population , reversible causes must be identified and resolved .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Thyroid disorders , illicit drug or stimulant use , and acute alcohol intoxication are among these causes . ### Output Text:
Thyroid disorders , illicit drug or stimulant use , and acute alcohol intoxication are among these causes .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: We report the case of a 30 - year - old Caucasian man who came to the emergency department in atrial fibrillation with rapid ventricular response . ### Output Text:
We report the case of a 30 - year - old Caucasian man who came to the emergency department in atrial fibrillation with rapid ventricular response .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: His medical history was unremarkable , except for minor fractures of the fingers and foot . ### Output Text:
His medical history was unremarkable , except for minor fractures of the fingers and foot .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Thyroid - stimulating hormone , magnesium , and potassium levels were within normal limits , urine drug screen was negative , and alcohol use was denied . ### Output Text:
Thyroid - stimulating hormone , <span class="chemical">magnesium</span> , and <span class="chemical">potassium</span> levels were within normal limits , urine drug screen was negative , and <span class="chemical">alcohol</span> use was denied .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: However , when the patient was questioned about use of herbal products and supplements , the use of creatine monohydrate was revealed . ### Output Text:
However , when the patient was questioned about use of herbal products and supplements , the use of <span class="chemical">creatine</span> monohydrate was revealed .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The patient was admitted to the hospital , anticoagulated with unfractionated heparin , and given intravenous diltiazem for rate control and intravenous amiodarone for rate and rhythm control . ### Output Text:
The patient was admitted to the hospital , anticoagulated with unfractionated <span class="chemical">heparin</span> , and given intravenous <span class="chemical">diltiazem</span> for rate control and intravenous <span class="chemical">amiodarone</span> for rate and rhythm control .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: When discharged less than 24 hours later , he was receiving metoprolol and aspirin , with follow - up plans for echocardiography and nuclear imaging to assess perfusion . ### Output Text:
When discharged less than 24 hours later , he was receiving <span class="chemical">metoprolol</span> and <span class="chemical">aspirin</span> , with follow - up plans for echocardiography and nuclear imaging to assess perfusion .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Exogenous creatine is used by athletes to theoretically improve exercise performance . ### Output Text:
Exogenous <span class="chemical">creatine</span> is used by athletes to theoretically improve exercise performance .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Vegetarians may also take creatine to replace what they are not consuming from meat , fish , and other animal products . ### Output Text:
Vegetarians may also take <span class="chemical">creatine</span> to replace what they are not consuming from meat , fish , and other animal products .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Previous anecdotal reports have linked creatine to the development of arrhythmia . ### Output Text:
Previous anecdotal reports have linked <span class="chemical">creatine</span> to the development of arrhythmia .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Clinicians must be diligent when interviewing patients about their drug therapy histories and include questions about their use of herbal products and dietary supplements . ### Output Text:
Clinicians must be diligent when interviewing patients about their drug therapy histories and include questions about their use of herbal products and dietary supplements .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: In addition , it is important to report adverse effects associated with frequently consumed supplements and herbal products to the Food and Drug Administration and in the literature . ### Output Text:
In addition , it is important to report adverse effects associated with frequently consumed supplements and herbal products to the Food and Drug Administration and in the literature .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Seizures induced by the cocaine metabolite benzoylecgonine in rats . ### Output Text:
Seizures induced by the <span class="chemical">cocaine</span> metabolite <span class="chemical">benzoylecgonine</span> in rats .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The half - life ( t1 / 2 ) of cocaine is relatively short , but some of the consequences of its use , such as seizures and strokes , can occur hours after exposure . ### Output Text:
The half - life ( t1 / 2 ) of <span class="chemical">cocaine</span> is relatively short , but some of the consequences of its use , such as seizures and strokes , can occur hours after exposure .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: This led us to hypothesize that a metabolite of cocaine may be responsible for some of those delayed sequelae . ### Output Text:
This led us to hypothesize that a metabolite of <span class="chemical">cocaine</span> may be responsible for some of those delayed sequelae .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: We evaluated the potential of the major metabolite of cocaine , benzoylecgonine ( BE ) , to cause seizures . ### Output Text:
We evaluated the potential of the major metabolite of <span class="chemical">cocaine</span> , <span class="chemical">benzoylecgonine</span> ( <span class="chemical">BE</span> ) , to cause seizures .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Two separate equimolar doses ( 0 . 2 and 0 . 4 mumol ) of either cocaine or BE were injected ventricularly in unanesthetized juvenile rats . ### Output Text:
Two separate equimolar doses ( 0 . 2 and 0 . 4 mumol ) of either <span class="chemical">cocaine</span> or <span class="chemical">BE</span> were injected ventricularly in unanesthetized juvenile rats .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Treated rats were then evaluated for incidence , latency , and seizure pattern or for locomotor activity in animals without seizures . ### Output Text:
Treated rats were then evaluated for incidence , latency , and seizure pattern or for locomotor activity in animals without seizures .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: BE - Induced seizures occurred more frequently and had significantly longer latencies than those induced by equimolar amounts of cocaine . ### Output Text:
<span class="chemical">BE</span> - Induced seizures occurred more frequently and had significantly longer latencies than those induced by equimolar amounts of <span class="chemical">cocaine</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Whereas cocaine - induced seizures were best characterized as brief , generalized , and tonic and resulted in death , those induced by BE were prolonged , often multiple and mixed in type , and rarely resulted in death . ### Output Text:
Whereas <span class="chemical">cocaine</span> - induced seizures were best characterized as brief , generalized , and tonic and resulted in death , those induced by <span class="chemical">BE</span> were prolonged , often multiple and mixed in type , and rarely resulted in death .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Electrical recordings from the hippocampus showed a rhythmic progression in EEG frequency and voltage with clinical seizure expression . ### Output Text:
Electrical recordings from the hippocampus showed a rhythmic progression in EEG frequency and voltage with clinical seizure expression .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: BE - Injected rats that did not have seizures had significantly more locomotor activity than cocaine - injected animals without seizures . ### Output Text:
<span class="chemical">BE</span> - Injected rats that did not have seizures had significantly more locomotor activity than <span class="chemical">cocaine</span> - injected animals without seizures .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The finding that cocaine - and BE - induced seizures differ in several respects suggests more than one mechanism for cocaine - induced seizures and emphasizes the importance of a cocaine metabolite , BE . ### Output Text:
The finding that <span class="chemical">cocaine</span> - and <span class="chemical">BE</span> - induced seizures differ in several respects suggests more than one mechanism for <span class="chemical">cocaine</span> - induced seizures and emphasizes the importance of a <span class="chemical">cocaine</span> metabolite , <span class="chemical">BE</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The selective 5 - HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat . ### Output Text:
The selective 5 - HT6 receptor antagonist <span class="chemical">Ro4368554</span> restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Antagonists at serotonin type 6 ( 5 - HT ( 6 ) ) receptors show activity in models of learning and memory . ### Output Text:
Antagonists at <span class="chemical">serotonin</span> type 6 ( <span class="chemical">5 - HT</span> ( 6 ) ) receptors show activity in models of learning and memory .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Although the underlying mechanism ( s ) are not well understood , these effects may involve an increase in acetylcholine ( ACh ) levels . ### Output Text:
Although the underlying mechanism ( s ) are not well understood , these effects may involve an increase in <span class="chemical">acetylcholine</span> ( <span class="chemical">ACh</span> ) levels .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The present study sought to characterize the cognitive - enhancing effects of the 5 - HT ( 6 ) antagonist Ro4368554 ( 3 - benzenesulfonyl - 7 - ( 4 - methyl - piperazin - 1 - yl ) 1H - indole ) in a rat object recognition task employing a cholinergic ( scopolamine pretreatment ) and a serotonergic - ( tryptophan ( TRP ) depletion ) deficient model , and compared its pattern of action with that of the acetylcholinesterase inhibitor metrifonate . ### Output Text:
The present study sought to characterize the cognitive - enhancing effects of the <span class="chemical">5 - HT</span> ( 6 ) antagonist <span class="chemical">Ro4368554</span> ( <span class="chemical">3 - benzenesulfonyl - 7 - ( 4 - methyl - piperazin - 1 - yl ) 1H - indole</span> ) in a rat object recognition task employing a cholinergic ( <span class="chemical">scopolamine</span> pretreatment ) and a serotonergic - ( <span class="chemical">tryptophan</span> ( <span class="chemical">TRP</span> ) depletion ) deficient model , and compared its pattern of action with that of the acetylcholinesterase inhibitor <span class="chemical">metrifonate</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Initial testing in a time - dependent forgetting task employing a 24 - h delay between training and testing showed that metrifonate improved object recognition ( at 10 and 30 mg / kg , p . o . ) , whereas Ro4368554 was inactive . ### Output Text:
Initial testing in a time - dependent forgetting task employing a 24 - h delay between training and testing showed that <span class="chemical">metrifonate</span> improved object recognition ( at 10 and 30 mg / kg , p . o . ) , whereas <span class="chemical">Ro4368554</span> was inactive .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Both , Ro4368554 ( 3 and 10 mg / kg , intraperitoneally ( i . p . ) ) and metrifonate ( 10 mg / kg , p . o . , respectively ) reversed memory deficits induced by scopolamine and TRP depletion ( 10 mg / kg , i . p . , and 3 mg / kg , p . o . , respectively ) . ### Output Text:
Both , <span class="chemical">Ro4368554</span> ( 3 and 10 mg / kg , intraperitoneally ( i . p . ) ) and <span class="chemical">metrifonate</span> ( 10 mg / kg , p . o . , respectively ) reversed memory deficits induced by <span class="chemical">scopolamine</span> and <span class="chemical">TRP</span> depletion ( 10 mg / kg , i . p . , and 3 mg / kg , p . o . , respectively ) .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: In conclusion , although Ro4368554 did not improve a time - related retention deficit , it reversed a cholinergic and a serotonergic memory deficit , suggesting that both mechanisms may be involved in the facilitation of object memory by Ro4368554 and , possibly , other 5 - HT ( 6 ) receptor antagonists . ### Output Text:
In conclusion , although <span class="chemical">Ro4368554</span> did not improve a time - related retention deficit , it reversed a cholinergic and a serotonergic memory deficit , suggesting that both mechanisms may be involved in the facilitation of object memory by <span class="chemical">Ro4368554</span> and , possibly , other <span class="chemical">5 - HT</span> ( 6 ) receptor antagonists .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose . ### Output Text:
Evaluation of the anticocaine monoclonal antibody <span class="chemical">GNC92H2</span> as an immunotherapy for cocaine overdose .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The illicit use of cocaine continues in epidemic proportions and treatment for cocaine overdose remains elusive . ### Output Text:
The illicit use of <span class="chemical">cocaine</span> continues in epidemic proportions and treatment for cocaine overdose remains elusive .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Current protein - based technology offers a new therapeutic venue by which antibodies bind the drug in the blood stream , inactivating its toxic effects . ### Output Text:
Current protein - based technology offers a new therapeutic venue by which antibodies bind the drug in the blood stream , inactivating its toxic effects .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The therapeutic potential of the anticocaine antibody GNC92H2 was examined using a model of cocaine overdose . ### Output Text:
The therapeutic potential of the anticocaine antibody <span class="chemical">GNC92H2</span> was examined using a model of cocaine overdose .