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"pmid": "3011911"
},
{
"citation": "Tissue Antigens. 1972;2(3):267-79",
"pmid": "4586481"
},
{
"citation": "Nature. 1984 Aug 23-29;310(5979):650-5",
"pmid": "6088985"
},
{
"citation": "J Immunol. 1985 Jan;134(1):630-6",
"pmid": "2981096"
},
{
"citation": "Transplantation. 1977 Mar;23(3):271-6",
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},
{
"citation": "J Immunol. 1985 Feb;134(2):1257-61",
"pmid": "2981267"
},
{
"citation": "J Immunogenet. 1983 Oct;10(5):379-93",
"pmid": "6196415"
}
] | false | eng | Immunol Res | 8611087 | 0257-277X | United States | [] | "2024-08-13T08:46:09.970820Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[Role of nuclear medicine in orthopedic surgery]. | 61(4) | 411-24 | Nihon Seikeigeka Gakkai zasshi | [
{
"affiliation": "",
"forename": "N",
"identifier": "",
"initials": "N",
"lastname": "Tonami"
}
] | 1987-04 | 3305741 | D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging*; D016025:Bone Transplantation; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D011859:Radiography; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives | D016428:Journal Article | C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013669:Technetium Tc 99m Medronate | [] | false | jpn | Nihon Seikeigeka Gakkai Zasshi | 0413716 | 0021-5325 | Japan | [] | "2024-08-13T08:46:09.972061Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Transcutaneous electrical nerve stimulation in acute hand infections. | 12(2) | 267-8 | Twenty-six patients with severe hand infections requiring operative drainage and admission to hospital were entered into a prospective, randomised, placebo-controlled trial. This was to test the use of a functioning transcutaneous electrical nerve stimulator and a non-functioning transcutaneous electrical nerve stimulator for pain relief in the first three postoperative days. Those patients with a functioning transcutaneous electrical nerve stimulator required significantly less analgesia. They also demonstrated highly significant improvement in their range of total active movement over those patients with a non-functioning transcutaneous electrical nerve stimulator. We recommend the use of transcutaneous electrical nerve stimulator after operation to reduce pain and improve mobility. | Journal of hand surgery (Edinburgh, Scotland) | [
{
"affiliation": "",
"forename": "D N",
"identifier": "",
"initials": "DN",
"lastname": "Quinton"
},
{
"affiliation": "",
"forename": "J P",
"identifier": "",
"initials": "JP",
"lastname": "Sloan"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Theakstone"
}
] | 1987-06 | 3305743 | D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000601:surgery*; D002986:Clinical Trials as Topic; D004599:Electric Stimulation Therapy; D005260:Female; D006225:Hand / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement; D010149:Pain, Postoperative / Q000628:therapy*; D011897:Random Allocation; D004561:Transcutaneous Electric Nerve Stimulation | D016430:Clinical Trial; D016428:Journal Article; D016449:Randomized Controlled Trial | 10.1016/0266-7681_87_90030-1 | [] | false | eng | J Hand Surg Br | 8403839 | 0266-7681 | Scotland | [] | "2024-08-13T08:46:09.974074Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[New trends in the study of vitamin D and related hormones]. | 61(4) | 425-38 | Nihon Seikeigeka Gakkai zasshi | [
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Abe"
}
] | 1987-04 | 3305742 | D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002147:Calmodulin / Q000502:physiology; D002454:Cell Differentiation; D006801:Humans; D008222:Lymphokines / Q000502:physiology; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010012:Osteogenesis; D064030:S100 Calcium Binding Protein G / Q000502:physiology; D012867:Skin / Q000166:cytology / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism / Q000502:physiology* | D016428:Journal Article; D016454:Review | D002147:Calmodulin; D008222:Lymphokines; D064030:S100 Calcium Binding Protein G; D014807:Vitamin D; C008718:osteoclast activating factor | [] | false | jpn | Nihon Seikeigeka Gakkai Zasshi | 0413716 | 0021-5325 | Japan | [] | "2024-08-13T08:46:09.974930Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Brachiocephalic artery stenosis presenting with objective tinnitus. | 101(7) | 718-20 | The Journal of laryngology and otology | [
{
"affiliation": "",
"forename": "J B",
"identifier": "",
"initials": "JB",
"lastname": "Campbell"
},
{
"affiliation": "",
"forename": "R M",
"identifier": "",
"initials": "RM",
"lastname": "Simons"
}
] | 1987-07 | 3305745 | D001157:Arterial Occlusive Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D016122:Brachiocephalic Trunk / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D011859:Radiography; D014012:Tinnitus / Q000209:etiology* | D002363:Case Reports; D016428:Journal Article | 10.1017/s0022215100102580 | [] | false | eng | J Laryngol Otol | 8706896 | 0022-2151 | England | [] | "2024-08-13T08:46:09.975635Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Clinical trials in colorectal cancer: experience of the Gastrointestinal Tumor Study Group and the Southwest Oncology Group. | 2(2) | 100-6 | Clinical trials in patients with metastatic and locally advanced colorectal carcinoma performed by the Southwest Oncology and Gastrointestinal Tumor Study Groups are reviewed. Therapy of metastatic disease remains unsatisfactory, with new agents and biochemical modulation being studied at present. Adjuvant trials have demonstrated the need for randomization and the inclusion of control groups. Preliminary results are consistent with potential usefulness of a combined modality approach in rectal carcinoma patients (stages B2 and C), with no effects on survival and/or recurrences in colon cancer. | International journal of colorectal disease | [
{
"affiliation": "",
"forename": "R M",
"identifier": "",
"initials": "RM",
"lastname": "Bukowski"
}
] | 1987-06 | 3305744 | D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D011446:Prospective Studies; D011897:Random Allocation; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000628:therapy; D014481:United States | D016430:Clinical Trial; D003160:Comparative Study; D016428:Journal Article; D016449:Randomized Controlled Trial | D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents | 10.1007/BF01647701 | [
{
"citation": "CA Cancer J Clin. 1983 Jan-Feb;33(1):9-25",
"pmid": "6401581"
},
{
"citation": "Cancer Treat Rep. 1982 Feb;66(2):381-3",
"pmid": "7055820"
},
{
"citation": "J Clin Oncol. 1987 Feb;5(2):272-7",
"pmid": "3543246"
},
{
"citation": "Invest New Drugs. 1984;2(4):401-4",
"pmid": "6239836"
},
{
"citation": "Cancer. 1979 Oct;44(4):1215-21",
"pmid": "387204"
},
{
"citation": "Invest New Drugs. 1984;2(4):391-5",
"pmid": "6334665"
},
{
"citation": "Cancer Treat Rep. 1976 Jun;60(6):733-7",
"pmid": "954013"
},
{
"citation": "N Engl J Med. 1984 Mar 22;310(12 ):737-43",
"pmid": "6366550"
},
{
"citation": "Cancer Res. 1981 Sep;41(9 Pt 1):3288-95",
"pmid": "6973389"
},
{
"citation": "Cancer. 1983 Jan 1;51(1):20-4",
"pmid": "6217886"
},
{
"citation": "J Clin Oncol. 1984 Jul;2(7):770-3",
"pmid": "6234380"
},
{
"citation": "Cancer Treat Rep. 1982 Dec;66(12):2099-100",
"pmid": "7139653"
},
{
"citation": "Cancer Treat Rep. 1987 Dec;71(12):1319-20",
"pmid": "2446754"
},
{
"citation": "Cancer. 1979 Jul;44(1):48-51",
"pmid": "378365"
},
{
"citation": "N Engl J Med. 1986 Nov 13;315 (20):1294-5",
"pmid": "3773947"
},
{
"citation": "N Engl J Med. 1985 Jun 6;312(23 ):1465-72",
"pmid": "2859523"
}
] | false | eng | Int J Colorectal Dis | 8607899 | 0179-1958 | Germany | [] | "2024-08-13T08:46:09.976866Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
The saga of the International Union of Angiology. | 6(1) | 1-4 | International angiology : a journal of the International Union of Angiology | [
{
"affiliation": "",
"forename": "J F",
"identifier": "",
"initials": "JF",
"lastname": "Merlen"
}
] | 1987 | 3305740 | D049673:History, 20th Century; D012955:Societies, Medical / Q000266:history*; D014652:Vascular Diseases / Q000266:history* | D016456:Historical Article; D016428:Journal Article | [] | false | eng | Int Angiol | 8402693 | 0392-9590 | Italy | [] | "2024-08-13T08:46:09.977524Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
[J.F. Merlen (1912-1986)]. | 12(3) | 234-7 | Journal des maladies vasculaires | [
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Olivier"
}
] | 1987 | 3305748 | D005602:France; D049673:History, 20th Century; D007388:Internal Medicine / Q000266:history; D014652:Vascular Diseases | D019215:Biography; D016456:Historical Article; D016428:Journal Article | [] | false | fre | J.F. Merlen (1912-1986). | J Mal Vasc | 7707965 | 0398-0499 | France | [] | "2024-08-13T08:46:09.978132Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Macrophage migration inhibition induced by MDP, LPS, PMA, and MIF/MAF: reversal by macrophage migration enhancement factor (MEF), L-fucose, L-fucosyl BSA, D-mannose, and D-mannosyl BSA. | 42(3) | 197-203 | Our data establish that migration inhibition factor (MIF) and migration enhancement factor (MEF) mutually neutralize the effect of each other in a concentration-dependent manner. The monosaccharides L-fucose and D-mannose were also shown to reverse MIF and additionally to stimulate alveolar macrophage (AM) migration in the absence of MIF. The specific activity of these sugars was increased 200-fold when conjugated to bovine serum albumin (BSA). Macrophage activation is usually observed concurrently with migration inhibition when macrophages are incubated with MIF preparations. Migration inhibition occurred also when AM were incubated in the presence of known metabolic activators (MDP, PMA, and LPS). It was found that L-fucose, D-mannose, L-fucosyl BSA, and D-mannosyl BSA could reverse migration inhibition caused by MIF as well as by these metabolic activators. These observations suggest that reversal of MIF by L-fucose is unexplained solely on the basis that L-fucose is functioning as a competitive inhibitor; instead, they suggest that MEF and the above sugars and their conjugates stimulate AM through a receptor system different from the MIF receptor. These observations support the concept that MEF is an important macrophage modulator in CMI responses. | Journal of leukocyte biology | [
{
"affiliation": "",
"forename": "M R",
"identifier": "",
"initials": "MR",
"lastname": "Gordon"
},
{
"affiliation": "",
"forename": "K",
"identifier": "",
"initials": "K",
"lastname": "Chida"
},
{
"affiliation": "",
"forename": "I",
"identifier": "",
"initials": "I",
"lastname": "Takata"
},
{
"affiliation": "",
"forename": "Q N",
"identifier": "",
"initials": "QN",
"lastname": "Myrvik"
}
] | 1987-09 | 3305746 | D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology; D000818:Animals; D002464:Cell Migration Inhibition; D002630:Chemotactic Factors / Q000494:pharmacology*; D005260:Female; D005643:Fucose / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008222:Lymphokines / Q000494:pharmacology*; D008263:Macrophage Migration-Inhibitory Factors / Q000494:pharmacology*; D016215:Macrophage-Activating Factors; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008358:Mannose / Q000494:pharmacology; D011817:Rabbits; D012709:Serum Albumin; D012710:Serum Albumin, Bovine / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't; D013487:Research Support, U.S. Gov't, P.H.S. | D002630:Chemotactic Factors; D008070:Lipopolysaccharides; D008222:Lymphokines; D008263:Macrophage Migration-Inhibitory Factors; D016215:Macrophage-Activating Factors; D012709:Serum Albumin; C053610:fucose-bovine serum albumin conjugate; C053609:macrophage migration enhancement factor; C023840:mannose-bovine serum albumin conjugate; D012710:Serum Albumin, Bovine; D005643:Fucose; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D013755:Tetradecanoylphorbol Acetate; D008358:Mannose | 10.1002/jlb.42.3.197 | [] | false | eng | J Leukoc Biol | 8405628 | 0741-5400 | England | [
{
"agency": "NHLBI NIH HHS",
"country": "United States",
"grant_acronym": "HL",
"grant_id": "HL31624"
}
] | "2024-08-13T08:46:09.980263Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
[Value and place of real-time ultrasonic diagnosis combined with continuous-wave Doppler in the diagnosis and follow-up of thromboembolic disease]. | 12(3) | 246-8 | The authors compared the results of real time ultrasound imaging and continuous wave Doppler (Echography-Doppler with bilateral venography and ilio-cavography in the diagnosis and the follow-up of deep venous thrombosis (D.V.T.). Diagnosis of D.V.T. The value of echography-Doppler (ED) compared to venography is studied on 297 patients (590 legs) suspected of D.V.T. (221) or pulmonary emboli (76). The two methods give concording results in 95% (563/590). Discrepancies (27) are more often located in distal veins. If we refer to venography as the gold standard, sensitivity of ED is 98% (236/242) and specificity is 95% (327/344). Other diagnosis are possible: hematoma (9), extrinsic compression (15), Baker's cyst (4), muscular problems (3)... Topographic value Sensitivity in isolated calf vein thrombosis is 90% (54/60 are detected, 22 are bilateral). 4/6 false negatives are located in the presumable healthy legs. Sensitivity in proximal D.V.T. is excellent 100% (182 D.V.T. with 28 bilateral). The upper extremity of the thrombus is located exactly by ED whatever the topography (35 in the inferior vena cava, three of them beyond the renal veins), the degree of obstruction (partially occluded veins: 32), and even if it's extended or not (27). Follow-up of D.V.T. Assessment of the results in 80 patients under treatment is identical with the two methods, whatever the topography, the degree of obstruction and the evolution of thrombosis. E.D. predictive value in therapeutic efficiency is discussed according to the evolution data in 260 patients. Screening of D.V.T. ED is compared to venography (13) and/or Fibrinogen test (15), in 23 patients (46 legs) with high risk of thrombosis.(ABSTRACT TRUNCATED AT 250 WORDS) | Journal des maladies vasculaires | [
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Elias"
},
{
"affiliation": "",
"forename": "J L",
"identifier": "",
"initials": "JL",
"lastname": "Bouvier"
},
{
"affiliation": "",
"forename": "G",
"identifier": "",
"initials": "G",
"lastname": "Lecorff"
},
{
"affiliation": "",
"forename": "G",
"identifier": "",
"initials": "G",
"lastname": "Lagrange"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Benichou"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Serradimigni"
}
] | 1987 | 3305749 | D005500:Follow-Up Studies; D006801:Humans; D007084:Iliac Vein / Q000000981:diagnostic imaging; D010690:Phlebography; D011655:Pulmonary Embolism / Q000175:diagnosis*; D013924:Thrombophlebitis / Q000175:diagnosis*; D014463:Ultrasonography; D014682:Vena Cava, Inferior / Q000000981:diagnostic imaging | D016428:Journal Article | [] | false | fre | Valeur et place de L'échographie temps réel couplée au Doppler continu dans le diagnostic et la surveillance de la maladie thrombo-embolique. | J Mal Vasc | 7707965 | 0398-0499 | France | [] | "2024-08-13T08:46:09.981177Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Role of epidermal cell thymocyte-activating factor in the proliferation and differentiation of murine B cells. | 42(3) | 222-9 | The role of antigen nonspecific cytokines in T- and B-lymphocyte responses is now well established. Interleukin-1 (IL-1) has been shown to augment B-cell maturation and proliferation. While the major source of IL-1 is from monocytes or macrophages, other cell types have been shown to produce IL-1-like cytokines. Epidermal cells produce a cytokine termed "epidermal cell-derived thymocyte-activating factor" (ETAF) which is similar if not identical with monocyte-derived IL-1. In this report we show that ETAF induces polyclonal stimulation of murine B cells. We show that ETAF augments B cell proliferation and differentiation in the absence of any added antigens or mitogens. This activity can be partially inhibited by anti-IL-1 antibodies. ETAF appears to activate B cells directly, although its activity is increased in the presence of T cells. Thus, ETAF may be involved in local polyclonal antibody responses occurring in the skin. | Journal of leukocyte biology | [
{
"affiliation": "",
"forename": "P S",
"identifier": "",
"initials": "PS",
"lastname": "Pillai"
},
{
"affiliation": "",
"forename": "S D",
"identifier": "",
"initials": "SD",
"lastname": "Reynolds"
},
{
"affiliation": "",
"forename": "D W",
"identifier": "",
"initials": "DW",
"lastname": "Scott"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Gauldie"
},
{
"affiliation": "",
"forename": "D N",
"identifier": "",
"initials": "DN",
"lastname": "Sauder"
}
] | 1987-09 | 3305747 | D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001688:Biological Products / Q000502:physiology*; D002454:Cell Differentiation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D016207:Cytokines; D004817:Epidermis / Q000032:analysis*; D006801:Humans; D007376:Interleukin-2 / Q000032:analysis / Q000276:immunology / Q000502:physiology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000502:physiology | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't; D013487:Research Support, U.S. Gov't, P.H.S. | D001688:Biological Products; D016207:Cytokines; D007376:Interleukin-2; D008070:Lipopolysaccharides | 10.1002/jlb.42.3.222 | [] | false | eng | J Leukoc Biol | 8405628 | 0741-5400 | England | [
{
"agency": "NIA NIH HHS",
"country": "United States",
"grant_acronym": "AG",
"grant_id": "AGO 4956"
},
{
"agency": "NIAID NIH HHS",
"country": "United States",
"grant_acronym": "AI",
"grant_id": "AI 20757"
}
] | "2024-08-13T08:46:09.982587Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
[Chronic venous insufficiency and microcirculation. Physiopathologic and therapeutic reflections]. | 12(3) | 280-4 | In patients with chronic venous insufficiency, tissular damage occurs as a consequence of microcirculatory disturbances. Venular distension, venulo-arteriolar reflex and probably valves in collecting venules are the only microcirculatory protective mechanisms against venous pressure overload. Edema is primarily a consequence of increased capillary hydrostatic pressure. However, the increase of endothelial macromolecular transport and a true lymphatic microangiopathy are important contributive factors. Venous ulceration is hypoxic although the amount of total blood flow is normal in the surrounding tissue. Several hypothesis were proposed for explaining this nutritional steal: arterio-venous shunt vessels have never been shown consistently, peri-capillary fibrin deposition might block oxygen diffusion, and last but not least, the abnormal geometrical arrangement of the capillary bed is facilitating functional shunting. On a therapeutic point of view, behind the classical hemodynamic therapy, the microvascular approach to chronic venous insufficiency supports the use of lymphatic manual drainage for controlling edema and rheologic therapy for improving skin capillary perfusion. | Journal des maladies vasculaires | [
{
"affiliation": "",
"forename": "P",
"identifier": "",
"initials": "P",
"lastname": "Carpentier"
},
{
"affiliation": "",
"forename": "J L",
"identifier": "",
"initials": "JL",
"lastname": "Magne"
},
{
"affiliation": "",
"forename": "F",
"identifier": "",
"initials": "F",
"lastname": "Sarrot-Reynauld"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Franco"
}
] | 1987 | 3305750 | D006801:Humans; D008833:Microcirculation / Q000503:physiopathology*; D014689:Venous Insufficiency / Q000503:physiopathology* / Q000628:therapy | D004740:English Abstract; D016428:Journal Article; D016454:Review | [] | false | fre | Insuffisance veineuse chronique et microcirculation. Réflexions physiopathologiques et thérapeutiques. | J Mal Vasc | 7707965 | 0398-0499 | France | [] | "2024-08-13T08:46:09.983606Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
A mathematical analysis of small mammal populations. | 25(3) | 263-74 | Populations of Microtus montanus, the montane vole, have been extensively studied. It is known that their reproductive activity is closely linked to the availability of the chemicals in growing plants. We use a mathematical model here to study how the length of the vegetative season and the natural reproduction rhythm of voles are involved in the long term dynamics of the population numbers. In particular, we use data obtained from Timpie Springs, Utah, and from Jackson Hole, Wyoming, to formulate a model. The novelty of this model is its use of littering curves that highlight the temporally discrete nature of vole reproduction. The model shows how the timing of the vegetative season can influence vole population sizes. | Journal of mathematical biology | [
{
"affiliation": "",
"forename": "F C",
"identifier": "",
"initials": "FC",
"lastname": "Hoppensteadt"
},
{
"affiliation": "",
"forename": "L",
"identifier": "",
"initials": "L",
"lastname": "Murphy"
}
] | 1987 | 3305751 | D000818:Animals; D003411:Arvicolinae; D004777:Environment; D005260:Female; D008098:Litter Size; D008297:Male; D008433:Mathematics; D008954:Models, Biological; D011157:Population Dynamics; D012098:Reproduction | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't; D013486:Research Support, U.S. Gov't, Non-P.H.S. | 10.1007/BF00276436 | [
{
"citation": "J Mammal. 1977 Aug 20;58(3):347-53",
"pmid": "333050"
}
] | false | eng | J Math Biol | 7502105 | 0303-6812 | Germany | [] | "2024-08-13T08:46:09.984430Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Organized medicine's challenges today: "the good, the bad, and the ugly". | 76(7) | 499-502 | Journal of the Medical Association of Georgia | [
{
"affiliation": "",
"forename": "J H",
"identifier": "",
"initials": "JH",
"lastname": "Sammons"
}
] | 1987-07 | 3305752 | D000574:American Medical Association; D004501:Education, Medical; D005845:Georgia; D006264:Health Benefit Plans, Employee; D007883:Legislation, Medical / Q000639:trends*; D006278:Medicare; D014481:United States | D016428:Journal Article | [] | false | eng | J Med Assoc Ga | 7505620 | 0025-7028 | United States | [] | "2024-08-13T08:46:09.986263Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
Host-parasite relationship in superficial mycoses. | 70 Suppl 3() | 14-6 | Journal of the Medical Association of Thailand = Chotmaihet thangphaet | [
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Ogawa"
},
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Tsuboi"
}
] | 1987-04 | 3305753 | D002176:Candida albicans / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D003881:Dermatomycoses / Q000469:parasitology*; D006790:Host-Parasite Interactions; D006801:Humans; D012867:Skin / Q000469:parasitology* | D016428:Journal Article | [] | false | eng | J Med Assoc Thai | 7507216 | 0125-2208 | Thailand | [] | "2024-08-13T08:46:09.986893Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
Ultrastructural localization of wheat germ agglutinin-binding sites in Escherichia coli with wheat germ agglutinin-gold complexes. | 36(1-2) | 36-9 | Journal of electron microscopy | [
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Morioka"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Tachibana"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Suganuma"
}
] | 1987 | 3305755 | D004926:Escherichia coli / Q000276:immunology* / Q000648:ultrastructure; D017979:Gold Colloid; D008854:Microscopy, Electron / Q000379:methods; D011975:Receptors, Mitogen / Q000032:analysis*; D014909:Wheat Germ Agglutinins / Q000032:analysis* | D016428:Journal Article | D017979:Gold Colloid; D011975:Receptors, Mitogen; D014909:Wheat Germ Agglutinins; C027503:wheat germ agglutinin receptor; C051777:wheat germ agglutinin-gold | [] | false | eng | J Electron Microsc (Tokyo) | 7611157 | 0022-0744 | Japan | [] | "2024-08-13T08:46:09.987591Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
An attempt to detect melanoma-associated antigen by labelled monoclonal antibodies in deparaffinized tissue sections. | 70 Suppl 3() | 31-5 | Journal of the Medical Association of Thailand = Chotmaihet thangphaet | [
{
"affiliation": "",
"forename": "P",
"identifier": "",
"initials": "P",
"lastname": "Suthipinittharm"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Kiela"
},
{
"affiliation": "",
"forename": "K",
"identifier": "",
"initials": "K",
"lastname": "Soltani"
}
] | 1987-04 | 3305754 | D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D001360:Avidin; D001710:Biotin; D003937:Diagnosis, Differential; D006652:Histological Techniques; D006801:Humans; D008545:Melanoma / Q000032:analysis / Q000175:diagnosis; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000032:analysis*; D009506:Nevus / Q000032:analysis / Q000175:diagnosis; D010544:Peroxidases / Q000037:antagonists & inhibitors | D016428:Journal Article | D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D001360:Avidin; D001710:Biotin; D010544:Peroxidases | [] | false | eng | J Med Assoc Thai | 7507216 | 0125-2208 | Thailand | [] | "2024-08-13T08:46:09.988611Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
An improved method for embedding with Quetol 651 and ERL 4206 for stereoscopic observation of thick sections under 400 kV transmission electron microscope. | 36(3) | 133-5 | Journal of electron microscopy | [
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Kushida"
},
{
"affiliation": "",
"forename": "T",
"identifier": "",
"initials": "T",
"lastname": "Kushida"
},
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Iijima"
},
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Aita"
}
] | 1987 | 3305756 | D000818:Animals; D004853:Epoxy Resins; D006652:Histological Techniques; D008297:Male; D051379:Mice; D008854:Microscopy, Electron / Q000379:methods*; D011145:Polyvinyls; D012671:Seminiferous Tubules / Q000648:ultrastructure*; D013737:Testis / Q000648:ultrastructure* | D016428:Journal Article | D004853:Epoxy Resins; D011145:Polyvinyls; C053660:ERL 4206; C035364:Quetol 651 | [] | false | eng | J Electron Microsc (Tokyo) | 7611157 | 0022-0744 | Japan | [] | "2024-08-13T08:46:09.989349Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Receptors for lactogenic hormones in the ovine corpus luteum. II: Specific inactivation of ovine prolactin. | 113(3) | 375-81 | Sheep corpus luteum homogenates and membrane fractions discriminate between 125I-labelled human GH (hGH) and ovine prolactin (oPRL). The present studies were designed to establish whether ovine luteal tissue possessed a prolactin-specific inactivating enzyme. Preincubation of sheep luteal microsomes and cytosol fractions with 125I-labelled hGH had little effect on the ability of the hormone to rebind to pig luteal lactogenic receptors. In contrast, sheep luteal tissue fractions markedly decreased the binding ability of 125I-labelled oPRL. However, despite the profound loss of receptor-binding activity, there was no change in protein-bound radioactivity, nor in the elution profile of 125I-labelled oPRL by gel chromatography on Sephadex G-100. Moreover, the disparity between 125I-labelled hGH and oPRL was not overcome by preincubation of sheep luteal membranes with protease inhibitors of differing specificities. We conclude that the disparity between the binding of hGH and oPRL in ovine tissues was due to the selective inactivation of oPRL. However, the activity responsible did not degrade the hormone extensively, nor was its action blocked by a range of protease inhibitors. | The Journal of endocrinology | [
{
"affiliation": "",
"forename": "T A",
"identifier": "",
"initials": "TA",
"lastname": "Bramley"
},
{
"affiliation": "",
"forename": "G S",
"identifier": "",
"initials": "GS",
"lastname": "Menzies"
},
{
"affiliation": "",
"forename": "A S",
"identifier": "",
"initials": "AS",
"lastname": "McNeilly"
},
{
"affiliation": "",
"forename": "H G",
"identifier": "",
"initials": "HG",
"lastname": "Friesen"
}
] | 1987-06 | 3305757 | D000818:Animals; D003338:Corpus Luteum / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D011480:Protease Inhibitors / Q000494:pharmacology; D011981:Receptors, Prolactin / Q000378:metabolism*; D012756:Sheep; D013552:Swine | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't; D013487:Research Support, U.S. Gov't, P.H.S. | D011480:Protease Inhibitors; D011981:Receptors, Prolactin; D011388:Prolactin; D013006:Growth Hormone; D010447:Peptide Hydrolases | 10.1677/joe.0.1130375 | [] | false | eng | J Endocrinol | 0375363 | 0022-0795 | England | [
{
"agency": "NICHD NIH HHS",
"country": "United States",
"grant_acronym": "HD",
"grant_id": "HD-07843-11"
}
] | "2024-08-13T08:46:09.990354Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Changes in gonadotrophin-releasing hormone and LH in Japanese quail during the first few days of photostimulation. | 113(3) | 419-22 | Castrated Japanese quail responded to a single long day with a five- to eightfold increase in plasma LH levels. A rise in LH secretion appeared 19-24 h after dawn and LH levels were still increased 3 days later, despite the fact that the birds had been returned to a short daylength. Pituitary LH content decreased, reflecting these changes in secretion, although significant falls in content were only found 36-96 h after dawn, when LH secretion was maximal. Hypothalamic gonadotrophin-releasing hormone content was not altered. One interpretation of this is that increased synthesis of the peptide compensates fully for the increased secretion. | The Journal of endocrinology | [
{
"affiliation": "",
"forename": "J A",
"identifier": "",
"initials": "JA",
"lastname": "Creighton"
},
{
"affiliation": "",
"forename": "B K",
"identifier": "",
"initials": "BK",
"lastname": "Follett"
}
] | 1987-06 | 3305758 | D000818:Animals; D003370:Coturnix / Q000502:physiology*; D007031:Hypothalamus / Q000378:metabolism; D008027:Light; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D009919:Orchiectomy; D010902:Pituitary Gland / Q000378:metabolism; D010906:Pituitary Hormone-Releasing Hormones / Q000378:metabolism*; D011784:Quail / Q000502:physiology*; D013997:Time Factors | D016428:Journal Article | D010906:Pituitary Hormone-Releasing Hormones; D007986:Luteinizing Hormone | 10.1677/joe.0.1130419 | [] | false | eng | J Endocrinol | 0375363 | 0022-0795 | England | [] | "2024-08-13T08:46:09.992362Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Hormone profiles for progesterone, oestradiol, prolactin, plasma renin activity, aldosterone and corticosterone during pregnancy and pseudopregnancy in two strains of rat: correlation with renal studies. | 113(3) | 435-44 | Plasma samples were obtained throughout pregnancy and pseudopregnancy from Sprague-Dawley (SD) rats and during pregnancy from rats of the Munich Wistar (MW) strain. The concentrations of progesterone, oestradiol, prolactin, plasma renin activity (PRA), aldosterone and corticosterone were measured by radioimmunoassay to establish hormonal profiles in the two strains of rat. Circulating progesterone concentrations in both strains of rat were significantly higher during pregnancy than in virgin controls, except at term in the SD group. The hormonal pattern for pseudopregnancy was similar to that of the first half of pregnancy. Oestradiol concentrations were similar to, or lower than, those in virgin controls throughout pseudopregnancy and for the first 2 weeks of pregnancy in both strains of rat. Increased concentrations of steroid were seen only in the pregnant groups towards term. In SD rats, highest prolactin concentrations were apparent during the first half of pregnancy and pseudopregnancy, and at term in the pregnant group. Pregnant MW rats showed a different profile for this hormone, with low levels throughout pregnancy except at term. In all groups PRA rose to a peak at day 9 and decreased to day 16. Pregnant SD rats also showed a significant increase at term. Aldosterone concentrations were significantly increased at several stages of pregnancy in both strains of rat, particularly during the second half of gestation. Pseudopregnant animals showed a different hormone profile, with no significant changes until day 16 when lower concentrations were recorded. There was little variation in the circulating corticosterone concentration except in pregnant rats at term when levels fell. These findings are discussed in relation to the known renal changes of pregnancy and pseudopregnancy. | The Journal of endocrinology | [
{
"affiliation": "",
"forename": "H O",
"identifier": "",
"initials": "HO",
"lastname": "Garland"
},
{
"affiliation": "",
"forename": "J C",
"identifier": "",
"initials": "JC",
"lastname": "Atherton"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Baylis"
},
{
"affiliation": "",
"forename": "M R",
"identifier": "",
"initials": "MR",
"lastname": "Morgan"
},
{
"affiliation": "",
"forename": "C M",
"identifier": "",
"initials": "CM",
"lastname": "Milne"
}
] | 1987-06 | 3305759 | D000450:Aldosterone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood*; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D011555:Pseudopregnancy / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D013045:Species Specificity | D003160:Comparative Study; D016428:Journal Article | D000450:Aldosterone; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D012083:Renin; D003345:Corticosterone | 10.1677/joe.0.1130435 | [] | false | eng | J Endocrinol | 0375363 | 0022-0795 | England | [] | "2024-08-13T08:46:09.993345Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Effects of ovarian inhibin on pulsatile release of gonadotrophins and secretion of LHRH in ovariectomized rats: evidence against a central action of inhibin. | 113(3) | 449-55 | Intraperitoneal administration of bovine follicular fluid (bFF) decreased plasma concentrations of FSH in ovariectomized rats after 2-3 h, while plasma LH and prolactin were unaffected. In untreated ovariectomized animals the concentrations of these hormones were found to show pulsatile variations. Concomitant occurrence of peak values of LH and FSH was found in about 40% of the pulses. No pulses of FSH were observed after i.p. treatment with bFF or partly purified preparations of inhibin from bFF, but the pulsatile release of LH and prolactin remained similar. Infusion of bFF into the lateral ventricle of the brain did not alter the concentrations of FSH, whereas administration of bFF into the pituitary gland diminished the plasma concentrations of FSH. Anaesthesia (urethane plus xylazine) did not prevent the occurrence of the pulses of FSH and LH, but it reduced the pulse amplitude and clearance. During this anaesthesia, the concentrations of LHRH in the hypophysial stalk plasma decreased by 30% after administration of bFF, but did not alter after treatment with partly purified preparations of inhibin. It is concluded that the inhibin-like activity in bFF suppresses pulsatile FSH secretion in ovariectomized rats by an action on the pituitary gland, but has no effect on the pulsatile release of LH and prolactin. | The Journal of endocrinology | [
{
"affiliation": "",
"forename": "W J",
"identifier": "",
"initials": "WJ",
"lastname": "de Greef"
},
{
"affiliation": "",
"forename": "G A",
"identifier": "",
"initials": "GA",
"lastname": "Eilers"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "de Koning"
},
{
"affiliation": "",
"forename": "B",
"identifier": "",
"initials": "B",
"lastname": "Karels"
},
{
"affiliation": "",
"forename": "F H",
"identifier": "",
"initials": "FH",
"lastname": "de Jong"
}
] | 1987-06 | 3305760 | D000818:Animals; D001826:Body Fluids / Q000378:metabolism; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D007265:Inhibins / Q000494:pharmacology*; D007276:Injections, Intraventricular; D006080:Ovarian Follicle / Q000378:metabolism*; D010052:Ovariectomy; D010902:Pituitary Gland; D051381:Rats | D016428:Journal Article | D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone; D007265:Inhibins | 10.1677/joe.0.1130449 | [] | false | eng | J Endocrinol | 0375363 | 0022-0795 | England | [] | "2024-08-13T08:46:09.994548Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Accumulation, organization and deployment of oogenetically derived Xenopus yolk/nonyolk proteins. | 97 Suppl() | 45-64 | Journal of embryology and experimental morphology | [
{
"affiliation": "",
"forename": "R C",
"identifier": "",
"initials": "RC",
"lastname": "Smith"
},
{
"affiliation": "",
"forename": "A W",
"identifier": "",
"initials": "AW",
"lastname": "Neff"
},
{
"affiliation": "",
"forename": "G M",
"identifier": "",
"initials": "GM",
"lastname": "Malacinski"
}
] | 1986-10 | 3305761 | D000818:Animals; D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis; D002451:Cell Compartmentation; D002970:Cleavage Stage, Ovum; D003599:Cytoskeleton / Q000378:metabolism; D004527:Egg Proteins / Q000276:immunology / Q000378:metabolism*; D004530:Egg Yolk; D005455:Fluorescent Antibody Technique; D009865:Oocytes / Q000276:immunology / Q000378:metabolism; D009866:Oogenesis; D014981:Xenopus | D016428:Journal Article; D013486:Research Support, U.S. Gov't, Non-P.H.S. | D000911:Antibodies, Monoclonal; D000941:Antigens; D004527:Egg Proteins | [] | false | eng | 87310241 | J Embryol Exp Morphol | 7906439 | 0022-0752 | England | [] | "2024-08-13T08:46:09.995488Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Development of Ly-1+ B cells in immunodeficient CBA/N mice. | 166(3) | 804-9 | Spleen cells from CBA/N mice developing a systemic autoimmune disease after daily injection of CsA during an autologous bone marrow reconstitution were transferred into unmanipulated syngeneic recipients. Adoptive transfer allowed the development of Ly-1+ B cells, which shared Mac-1 differentiation antigen expression with the myelomonocytic lineage. Interestingly, expansion of formerly absent Ly-1+ B cells was paralleled by a severe reduction in common, Ly-1-, B cell development in the recipient. We conclude that precursors for Ly-1+ B lineage do exist in CBA/N mice. | The Journal of experimental medicine | [
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "de la Hera"
},
{
"affiliation": "",
"forename": "M A",
"identifier": "",
"initials": "MA",
"lastname": "Marcos"
},
{
"affiliation": "",
"forename": "M L",
"identifier": "",
"initials": "ML",
"lastname": "Toribio"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Marquez"
},
{
"affiliation": "",
"forename": "M L",
"identifier": "",
"initials": "ML",
"lastname": "Gaspar"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Martinez"
}
] | 1987-09-01 | 3305762 | D000818:Animals; D000950:Antigens, Ly / Q000276:immunology*; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000473:pathology; D003524:Cyclosporins; D006412:Hematopoietic Stem Cells / Q000473:pathology; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000473:pathology / Q000637:transplantation; D014916:Whole-Body Irradiation | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D000950:Antigens, Ly; D003524:Cyclosporins | 10.1084/jem.166.3.804 | [
{
"citation": "J Exp Med. 1975 Apr 1;141(4):788-803",
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{
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{
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{
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{
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{
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] | false | eng | J Exp Med | 2985109R | 0022-1007 | United States | [] | "2024-08-13T08:46:09.997898Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Identification of three stage-specific proteinases of Plasmodium falciparum. | 166(3) | 816-21 | We have identified and characterized three stage-specific proteinases of Plasmodium falciparum that are active at neutral pH. We analyzed ring-, trophozoite-, schizont-, and merozoite-stage parasites by gelatin substrate PAGE and characterized the identified proteinases with class-specific proteinase inhibitors. No proteinase activity was detected with rings. Trophozoites had a 28 kD proteinase that was inhibited by inhibitors of cysteine proteinases. Mature schizonts had a 35-40 kD proteinase that also was inhibited by cysteine proteinase inhibitors. Merozoite fractions had a 75 kD proteinase that was inhibited by serine proteinase inhibitors. The stage-specific activity of these proteinases and the correlation between the effects of proteinase inhibitors on the isolated enzymes with the effects of the inhibitors on whole parasites suggest potential critical functions for these proteinases in the life cycle of malaria parasites. | The Journal of experimental medicine | [
{
"affiliation": "",
"forename": "P J",
"identifier": "",
"initials": "PJ",
"lastname": "Rosenthal"
},
{
"affiliation": "",
"forename": "K",
"identifier": "",
"initials": "K",
"lastname": "Kim"
},
{
"affiliation": "",
"forename": "J H",
"identifier": "",
"initials": "JH",
"lastname": "McKerrow"
},
{
"affiliation": "",
"forename": "J H",
"identifier": "",
"initials": "JH",
"lastname": "Leech"
}
] | 1987-09-01 | 3305763 | D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D010450:Endopeptidases / Q000378:metabolism*; D005033:Ethylmaleimide / Q000494:pharmacology; D007531:Isoflurophate / Q000494:pharmacology; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000201:enzymology / Q000254:growth & development*; D011480:Protease Inhibitors / Q000494:pharmacology | D003160:Comparative Study; D016428:Journal Article; D013486:Research Support, U.S. Gov't, Non-P.H.S.; D013487:Research Support, U.S. Gov't, P.H.S. | D011480:Protease Inhibitors; D007531:Isoflurophate; D010664:Phenylmethylsulfonyl Fluoride; D010450:Endopeptidases; D005033:Ethylmaleimide | 10.1084/jem.166.3.816 | [
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},
{
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{
"citation": "Exp Parasitol. 1983 Jun;55(3):306-11",
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},
{
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},
{
"citation": "J Clin Invest. 1983 Oct;72(4):1357-64",
"pmid": "6630511"
},
{
"citation": "Mol Biochem Parasitol. 1984 Apr;11:267-82",
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},
{
"citation": "J Protozool. 1984 Aug;31(3):367-72",
"pmid": "6389846"
},
{
"citation": "Biochem Biophys Res Commun. 1984 Nov 14;124(3):703-10",
"pmid": "6391479"
},
{
"citation": "Proc Natl Acad Sci U S A. 1985 May;82(9):2784-8",
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{
"citation": "J Cell Biol. 1985 Dec;101(6):2302-9",
"pmid": "3905824"
},
{
"citation": "J Immunol. 1986 Mar 15;136(6):2245-51",
"pmid": "3512710"
},
{
"citation": "Mol Biochem Parasitol. 1986 Mar;18(3):389-400",
"pmid": "3515180"
},
{
"citation": "Science. 1976 Aug 20;193(4254):673-5",
"pmid": "781840"
},
{
"citation": "J Lab Clin Med. 1976 Aug;88(2):328-33",
"pmid": "956688"
},
{
"citation": "Am J Trop Med Hyg. 1978 Nov;27(6):1274-6",
"pmid": "365006"
},
{
"citation": "J Parasitol. 1979 Jun;65(3):418-20",
"pmid": "383936"
}
] | false | eng | J Exp Med | 2985109R | 0022-1007 | United States | [
{
"agency": "NIAID NIH HHS",
"country": "United States",
"grant_acronym": "AI",
"grant_id": "AI24349"
}
] | "2024-08-13T08:46:09.999185Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Seminar: Pathobiochemistry of shock. In honor of Prof. L. Róka. Giessen, 28-29 April 1987. Abstracts. | 25(4) | 205-39 | Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie | [] | 1987-04 | 3305764 | D049673:History, 20th Century; D006801:Humans; D012769:Shock / Q000503:physiopathology | D019215:Biography; D016456:Historical Article; D016428:Journal Article | [] | false | eng | J Clin Chem Clin Biochem | 7701860 | 0340-076X | Germany | [] | "2024-08-13T08:46:09.999949Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
Hyponatremia resulting from pelvic ultrasound preparation. | 25(3) | 216-7 | The Journal of family practice | [
{
"affiliation": "",
"forename": "M S",
"identifier": "",
"initials": "MS",
"lastname": "Lipsky"
},
{
"affiliation": "",
"forename": "D L",
"identifier": "",
"initials": "DL",
"lastname": "Zabak"
}
] | 1987-09 | 3305765 | D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000209:etiology*; D008875:Middle Aged; D010388:Pelvis; D014463:Ultrasonography; D014869:Water Intoxication / Q000150:complications* | D002363:Case Reports; D016422:Letter | [] | false | eng | J Fam Pract | 7502590 | 0094-3509 | United States | [] | "2024-08-13T08:46:10.000818Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
Is maternity care different in family practice? A pilot matched pair study. | 25(3) | 237-42 | In this pilot study, 81 patients booked for delivery by family physicians were matched to patients booked for delivery by obstetricians. Patients in both groups were at low obstetric risk. They were matched by age, parity, blood pressure, gestational age at delivery, and socioeconomic status. Patients booked with family physicians experienced fewer artificial rupture of membranes, inductions of labor, episiotomies, and forceps deliveries than those booked with obstetricians. These patients also spent a shorter time in hospital in spite of longer second stages of labor. Infant outcomes were equivalent in the two groups. A simple method of audit of maternity care that permits comparisons of the care provided by family physicians and obstetricians for obstetrically similar patients is described. This methodology employs matching within a given institution and facilitates the multicentered studies required to obtain the large populations needed to compare the process and outcome of infant and maternal care provided by these two types of physicians. | The Journal of family practice | [
{
"affiliation": "",
"forename": "E E",
"identifier": "",
"initials": "EE",
"lastname": "Rosenberg"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Klein"
}
] | 1987-09 | 3305766 | D002986:Clinical Trials as Topic; D036861:Delivery, Obstetric; D005194:Family Practice / Q000592:standards; D005260:Female; D006748:Hospital Departments / Q000592:standards*; D006801:Humans; D008429:Maternal Welfare; D008485:Medical Audit / Q000379:methods; D009774:Obstetrics / Q000592:standards; D009775:Obstetrics and Gynecology Department, Hospital / Q000592:standards*; D010865:Pilot Projects; D011247:Pregnancy; D011792:Quebec; D011897:Random Allocation | D016430:Clinical Trial; D003160:Comparative Study; D016428:Journal Article | [] | false | eng | J Fam Pract | 7502590 | 0094-3509 | United States | [] | "2024-08-13T08:46:10.001678Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Chronic pelvic pain. | 25(3) | 283-8 | Chronic pelvic pain is one of the most challenging gynecologic problems seen in primary care practice. Important causes of this problem include endometriosis, pelvic adhesions, chronic pelvic inflammatory disease, and the syndrome of chronic pelvic pain without obvious pathology. The diagnostic approach to chronic pelvic pain begins with a careful medical history and physical examination in conjunction with a comprehensive psychosocial assessment. Laboratory evaluation may include pelvic ultrasonography, psychometric testing, and diagnostic laparoscopy. Optimal management of these patients may require a multidisciplinary approach, integrating chronic pain management techniques with specific therapy. | The Journal of family practice | [
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Quan"
}
] | 1987-09 | 3305767 | D005260:Female; D005831:Genital Diseases, Female / Q000150:complications; D006801:Humans; D010148:Pain, Intractable / Q000209:etiology* / Q000523:psychology; D010388:Pelvis; D011602:Psychophysiologic Disorders / Q000150:complications | D016428:Journal Article; D016454:Review | [] | false | eng | J Fam Pract | 7502590 | 0094-3509 | United States | [] | "2024-08-13T08:46:10.002523Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Medical teaching in South Florida. How it started and how it got on its feet. | 74(7) | 483-6 | The Journal of the Florida Medical Association | [
{
"affiliation": "",
"forename": "F H",
"identifier": "",
"initials": "FH",
"lastname": "Stewart"
}
] | 1987-07 | 3305768 | D004501:Education, Medical / Q000266:history*; D005431:Florida; D049672:History, 19th Century; D049673:History, 20th Century | D016456:Historical Article; D016428:Journal Article | [] | false | eng | J Fla Med Assoc | 7505604 | 0015-4148 | United States | [] | "2024-08-13T08:46:10.004658Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
Attempts at cooperative approaches to graduate medical education--the saga of J.H.E.P. (Jacksonville Hospitals Education Program). | 74(7) | 487-93 | The Journal of the Florida Medical Association | [
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Michael"
}
] | 1987-07 | 3305769 | D005431:Florida; D049673:History, 20th Century; D006784:Hospitals, Teaching / Q000266:history*; D007396:Internship and Residency / Q000266:history* / Q000458:organization & administration; D009096:Multi-Institutional Systems / Q000266:history* | D016456:Historical Article; D016428:Journal Article | [] | false | eng | J Fla Med Assoc | 7505604 | 0015-4148 | United States | [] | "2024-08-13T08:46:10.005265Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
The Florida East Coast Railway Hospital: a study of early corporate medicine, 1906-1963. | 74(7) | 499-503 | The Journal of the Florida Medical Association | [
{
"affiliation": "",
"forename": "V A",
"identifier": "",
"initials": "VA",
"lastname": "Lockwood"
}
] | 1987-07 | 3305770 | D005431:Florida; D049673:History, 20th Century; D006761:Hospitals / Q000266:history*; D006788:Hospitals, Voluntary / Q000266:history*; D009786:Occupational Health Services / Q000266:history*; D011890:Railroads / Q000266:history* | D016456:Historical Article; D016428:Journal Article | [] | false | eng | J Fla Med Assoc | 7505604 | 0015-4148 | United States | [] | "2024-08-13T08:46:10.005990Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
Camp Miami, 1898. | 74(7) | 504-13 | The Journal of the Florida Medical Association | [
{
"affiliation": "",
"forename": "W M",
"identifier": "",
"initials": "WM",
"lastname": "Straight"
}
] | 1987-07 | 3305771 | D005431:Florida; D049672:History, 19th Century; D008887:Military Medicine; D014435:Typhoid Fever; D014481:United States; D014857:Warfare | D016456:Historical Article; D016428:Journal Article | [] | false | eng | J Fla Med Assoc | 7505604 | 0015-4148 | United States | [] | "2024-08-13T08:46:10.006626Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
History of graduate medical education at the University of Florida. | 74(7) | 514-5 | The Journal of the Florida Medical Association | [
{
"affiliation": "",
"forename": "J L",
"identifier": "",
"initials": "JL",
"lastname": "Dockery"
}
] | 1987-07 | 3305772 | D000068:Accreditation; D005431:Florida; D049672:History, 19th Century; D049673:History, 20th Century; D007396:Internship and Residency / Q000266:history* / Q000592:standards | D016456:Historical Article; D016428:Journal Article | [] | false | eng | J Fla Med Assoc | 7505604 | 0015-4148 | United States | [] | "2024-08-13T08:46:10.007242Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
The residency program at the University of South Florida. | 74(7) | 516-7 | The Journal of the Florida Medical Association | [
{
"affiliation": "",
"forename": "J M",
"identifier": "",
"initials": "JM",
"lastname": "Judisch"
}
] | 1987-07 | 3305773 | D005431:Florida; D049673:History, 20th Century; D007396:Internship and Residency / Q000266:history* | D016456:Historical Article; D016428:Journal Article | [] | false | eng | J Fla Med Assoc | 7505604 | 0015-4148 | United States | [] | "2024-08-13T08:46:10.008070Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
History of the Pensacola Educational Program. | 74(7) | 518-21 | The Journal of the Florida Medical Association | [
{
"affiliation": "",
"forename": "R D",
"identifier": "",
"initials": "RD",
"lastname": "Nauman"
}
] | 1987-07 | 3305774 | D005431:Florida; D005582:Foundations / Q000266:history* / Q000458:organization & administration; D049673:History, 20th Century; D006764:Hospitals, Community; D007396:Internship and Residency / Q000266:history* / Q000458:organization & administration | D016456:Historical Article; D016428:Journal Article | [] | false | eng | J Fla Med Assoc | 7505604 | 0015-4148 | United States | [] | "2024-08-13T08:46:10.008656Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
CME in Florida: an historical overview. | 74(7) | 522-4 | The Journal of the Florida Medical Association | [
{
"affiliation": "",
"forename": "R C",
"identifier": "",
"initials": "RC",
"lastname": "Fore"
},
{
"affiliation": "",
"forename": "P J",
"identifier": "",
"initials": "PJ",
"lastname": "Bouis"
}
] | 1987-07 | 3305775 | D004502:Education, Medical, Continuing / Q000266:history*; D005431:Florida; D049673:History, 20th Century; D008007:Licensure, Medical | D016456:Historical Article; D016428:Journal Article | [] | false | eng | J Fla Med Assoc | 7505604 | 0015-4148 | United States | [] | "2024-08-13T08:46:10.009372Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
[Allogeneic bone marrow transplantation in the treatment of leukemia--a preliminary report]. | 86(5) | 490-6 | Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association | [
{
"affiliation": "",
"forename": "Y C",
"identifier": "",
"initials": "YC",
"lastname": "Chen"
},
{
"affiliation": "",
"forename": "C H",
"identifier": "",
"initials": "CH",
"lastname": "Wang"
},
{
"affiliation": "",
"forename": "D T",
"identifier": "",
"initials": "DT",
"lastname": "Lin"
},
{
"affiliation": "",
"forename": "P T",
"identifier": "",
"initials": "PT",
"lastname": "Lui"
},
{
"affiliation": "",
"forename": "A L",
"identifier": "",
"initials": "AL",
"lastname": "Cheng"
},
{
"affiliation": "",
"forename": "T W",
"identifier": "",
"initials": "TW",
"lastname": "Liu"
},
{
"affiliation": "",
"forename": "W",
"identifier": "",
"initials": "W",
"lastname": "Tsay"
},
{
"affiliation": "",
"forename": "H F",
"identifier": "",
"initials": "HF",
"lastname": "Tien"
},
{
"affiliation": "",
"forename": "M C",
"identifier": "",
"initials": "MC",
"lastname": "Liu"
},
{
"affiliation": "",
"forename": "W M",
"identifier": "",
"initials": "WM",
"lastname": "Chuu"
}
] | 1987-05 | 3305776 | D016026:Bone Marrow Transplantation; D003524:Cyclosporins / Q000009:adverse effects; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007938:Leukemia / Q000401:mortality / Q000628:therapy*; D008297:Male; D014184:Transplantation, Homologous | D004740:English Abstract; D016428:Journal Article | D003524:Cyclosporins | [] | false | chi | Taiwan Yi Xue Hui Za Zhi | 0413761 | 0371-7682 | China (Republic : 1949- ) | [] | "2024-08-13T08:46:10.010412Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
A cooperative taxonomic study of mycobacteria isolated from armadillos infected with Mycobacterium leprae. | 132(10) | 2693-707 | Seventeen strains of mycobacteria, recovered from six armadillos experimentally infected with Mycobacterium leprae, were examined in ten different laboratories. This collaborative study included use of conventional bacteriological tests, lipid analyses, determination of mycobactins and peptidoglycans, characterization by Py-MS, and immunological, metabolic, pathological and DNA studies. These armadillo-derived mycobacteria (ADM) formed five homogeneous groups (numbered ADM 1 to 5) on the basis of phenetic analyses. However, DNA studies revealed only four homogeneous groups since group ADM 1 and one of the two strains in group ADM 3 showed a high level of DNA relatedness. The phenetic and DNA studies confirmed that the ADM strains differed from all other known mycobacteria. Cultural, biochemical, metabolic and pathogenic properties as well as DNA-DNA hybridizations clearly differentiated these ADM from M. leprae. | Journal of general microbiology | [
{
"affiliation": "",
"forename": "F",
"identifier": "",
"initials": "F",
"lastname": "Portaels"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Asselineau"
},
{
"affiliation": "",
"forename": "I",
"identifier": "",
"initials": "I",
"lastname": "Baess"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Daffé"
},
{
"affiliation": "",
"forename": "G",
"identifier": "",
"initials": "G",
"lastname": "Dobson"
},
{
"affiliation": "",
"forename": "P",
"identifier": "",
"initials": "P",
"lastname": "Draper"
},
{
"affiliation": "",
"forename": "D",
"identifier": "",
"initials": "D",
"lastname": "Gregory"
},
{
"affiliation": "",
"forename": "R M",
"identifier": "",
"initials": "RM",
"lastname": "Hall"
},
{
"affiliation": "",
"forename": "T",
"identifier": "",
"initials": "T",
"lastname": "Imaeda"
},
{
"affiliation": "",
"forename": "P A",
"identifier": "",
"initials": "PA",
"lastname": "Jenkins"
}
] | 1986-10 | 3305778 | D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001135:Armadillos / Q000382:microbiology*; D002374:Catalase / Q000032:analysis; D002855:Chromatography, Thin Layer; D004269:DNA, Bacterial / Q000032:analysis; D006595:Hexosamines / Q000032:analysis; D008055:Lipids / Q000032:analysis; D009161:Mycobacterium / Q000145:classification* / Q000201:enzymology; D009164:Mycobacterium Infections / Q000382:microbiology*; D009166:Mycobacterium leprae / Q000145:classification / Q000201:enzymology / Q000302:isolation & purification; D009170:Nontuberculous Mycobacteria / Q000145:classification / Q000302:isolation & purification; D010080:Oxazoles / Q000032:analysis; D004490:Xenarthra / Q000382:microbiology* | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D000596:Amino Acids; D004269:DNA, Bacterial; D006595:Hexosamines; D008055:Lipids; D010080:Oxazoles; C018608:mycobactins; D002374:Catalase | 10.1099/00221287-132-10-2693 | [] | false | eng | J Gen Microbiol | 0375371 | 0022-1287 | England | [] | "2024-08-13T08:46:10.013108Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Effect of alkylating agents on the expression of inducible genes of Escherichia coli. | 132(10) | 2677-84 | Increasing doses of alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine, diethyl sulphate and ethylmethane sulphonate cause an inhibition of the expression of the recA and sfiA genes of wild-type Escherichia coli. This behaviour was not observed in a lexA56 mutant which has a defective LexA repressor that is unable to bind to the SOS operator. Furthermore, an ada-1 mutant showed the same behaviour as the wild-type strain indicating that the adaptive proteins are not responsible for the inhibition of recA and sfiA at high doses of alkylating agents. These results suggest that the inhibitory effect of these alkylating agents may be found in the interaction between the LexA repressor and the control regions of sfiA and recA. On the other hand, high doses of either UV light or mitomycin C produced only a slight decrease in the induction of recA and sfiA, whereas bleomycin had no effect. The fact that a repressor structurally related to LexA repressor, such as LacI protein, showed the same behaviour as the LexA repressor when a Lac+ strain was treated with alkylating agents, suggests that these compounds can modify the binding abilities of repressors to DNA, producing a limited or even abolished release of repressors, and so decreasing the expression of inducible genes. | Journal of general microbiology | [
{
"affiliation": "",
"forename": "J A",
"identifier": "",
"initials": "JA",
"lastname": "Vericat"
},
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Guerrero"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Barbé"
}
] | 1986-10 | 3305777 | D000477:Alkylating Agents / Q000494:pharmacology*; D004249:DNA Damage; D004926:Escherichia coli / Q000235:genetics*; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects*; D005798:Genes, Bacterial / Q000187:drug effects*; D007544:Isopropyl Thiogalactoside / Q000494:pharmacology; D007763:Lac Operon / Q000187:drug effects; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D013463:Sulfuric Acid Esters / Q000494:pharmacology | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D000477:Alkylating Agents; D013463:Sulfuric Acid Esters; D008769:Methylnitronitrosoguanidine; D007544:Isopropyl Thiogalactoside; D005020:Ethyl Methanesulfonate; C011612:diethyl sulfate | 10.1099/00221287-132-10-2677 | [] | false | eng | J Gen Microbiol | 0375371 | 0022-1287 | England | [] | "2024-08-13T08:46:10.014099Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Changes in the plasma membrane of regenerating protoplasts of Candida albicans as revealed by freeze-fracture electron microscopy. | 132(10) | 2845-53 | Modifications occurring in the plasma membrane and their relationship to newly synthesized microfibrils were examined in regenerating protoplasts of Candida albicans by freeze-fracture electron microscopy. Freshly prepared protoplasts showed no residual wall material, and long invaginations covered the surface of the plasma membrane. Analysis of the external face (E-face) of the plasma membrane showed a significant decrease in the number of intramembranous particles (IMP) in comparison with the original cells. After 40 min incubation in regeneration medium, newly synthesized microfibrils which seemed to originate from protrusions in the plasma membrane were observed. The plasma membrane showed important modifications with respect to IMP. After 3 h 45 min, the cells were covered by an abnormal wall which showed isolated fibrils partially embedded in the matrix material. The plasma membrane of these partially regenerated protoplasts was similar to that of original cells. After 8 h, regeneration of the protoplasts seemed to be complete as no differences from the original cells were detected in the plasma membrane or the wall. Calcofluor white altered the deposition of wall polymers during regeneration, but did not modify the plasma membrane of the protoplasts. | Journal of general microbiology | [
{
"affiliation": "",
"forename": "F",
"identifier": "",
"initials": "F",
"lastname": "Miragall"
},
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Rico"
},
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Sentandreu"
}
] | 1986-10 | 3305779 | D002176:Candida albicans / Q000648:ultrastructure*; D002462:Cell Membrane / Q000648:ultrastructure; D005614:Freeze Fracturing; D008854:Microscopy, Electron; D011523:Protoplasts / Q000648:ultrastructure*; D012038:Regeneration; D013997:Time Factors | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | 10.1099/00221287-132-10-2845 | [] | false | eng | J Gen Microbiol | 0375371 | 0022-1287 | England | [] | "2024-08-13T08:46:10.015209Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Subdivision of daughter strains of bacille Calmette-Guérin (BCG) according to secreted protein patterns. | 132(11) | 3047-53 | In order to identify proteins secreted by live organisms, daughter strains of the Bacillus Calmette-Guérin (BCG) were grown for 4-7 d in a defined medium containing [35S]methionine. Secreted components were then separated by polyacrylamide gel electrophoresis under both denaturing and non-denaturing conditions, and analysed by autoradiography and in an Ambis beta-scanner. The results indicate that BCG daughter strains can be subdivided into two groups according to their secretion of a 46 kDa protein dimer consisting of two similar 23 kDa subunits. High-producer strains (Japanese, Brazilian and Russian) secrete very large quantities of this material, which constitutes approximately 23% of all secreted protein. These findings correlate with earlier studies in which degradation products of the protein dimer may have been identified, and with the data from patterns of cell wall lipids. | Journal of general microbiology | [
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Abou-Zeid"
},
{
"affiliation": "",
"forename": "I",
"identifier": "",
"initials": "I",
"lastname": "Smith"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Grange"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Steele"
},
{
"affiliation": "",
"forename": "G",
"identifier": "",
"initials": "G",
"lastname": "Rook"
}
] | 1986-11 | 3305780 | D001426:Bacterial Proteins / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D008715:Methionine / Q000378:metabolism; D008970:Molecular Weight; D009163:Mycobacterium bovis / Q000145:classification / Q000378:metabolism*; D011489:Protein Denaturation; D013462:Sulfur Radioisotopes | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D001426:Bacterial Proteins; D013462:Sulfur Radioisotopes; D008715:Methionine | 10.1099/00221287-132-11-3047 | [] | false | eng | J Gen Microbiol | 0375371 | 0022-1287 | England | [] | "2024-08-13T08:46:10.016248Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Development of Candida albicans hyphae in different growth media--variations in growth rates, cell dimensions and timing of morphogenetic events. | 132(11) | 3083-8 | In six liquid culture media, all of which stimulated Candida albicans to grow in the hyphal form, the rates of hyphal extension and increase in cellular ATP concentration, hyphal diameters, times of evagination of hyphae, times of septum formation and positions of septa in the hyphae appeared to vary independently. There were no discernible associations between properties such as length or volume of hyphal compartments at the time of septation and temporal parameters of hyphal growth. The results suggest that growth environment influences many of the processes contributing to hyphal development, but that these processes are not necessarily interrelated. | Journal of general microbiology | [
{
"affiliation": "",
"forename": "M J",
"identifier": "",
"initials": "MJ",
"lastname": "Sevilla"
},
{
"affiliation": "",
"forename": "F C",
"identifier": "",
"initials": "FC",
"lastname": "Odds"
}
] | 1986-11 | 3305781 | D000255:Adenosine Triphosphate / Q000378:metabolism; D002176:Candida albicans / Q000166:cytology / Q000254:growth & development*; D002473:Cell Wall / Q000378:metabolism; D003470:Culture Media; D009024:Morphogenesis; D013997:Time Factors | D016428:Journal Article | D003470:Culture Media; D000255:Adenosine Triphosphate | 10.1099/00221287-132-11-3083 | [] | false | eng | J Gen Microbiol | 0375371 | 0022-1287 | England | [] | "2024-08-13T08:46:10.018214Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
The phosphonium ion efflux system of Escherichia coli: relationship to the ethidium efflux system and energetic studies. | 132(11) | 3187-93 | The extent of accumulation of methyltriphenylphosphonium ion by Escherichia coli was shown to be dependent on the permeability of the outer membrane and the activity of an efflux system for this compound. Evidence consistent with the operation of a single efflux system for compounds such as phosphonium ions, phenanthridiniums and flavines is presented. Studies on the energy coupling mechanism for this efflux system indicated that it was driven by the transmembrane proton electrochemical gradient. | Journal of general microbiology | [
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Midgley"
}
] | 1986-11 | 3305782 | D004734:Energy Metabolism; D004926:Escherichia coli / Q000378:metabolism*; D004996:Ethidium / Q000378:metabolism*; D005609:Free Radicals; D008564:Membrane Potentials; D009861:Onium Compounds / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000378:metabolism; D011726:Pyridinium Compounds / Q000378:metabolism; D014320:Trityl Compounds / Q000378:metabolism* | D016428:Journal Article | D005609:Free Radicals; D009861:Onium Compounds; D009943:Organophosphorus Compounds; D011726:Pyridinium Compounds; D014320:Trityl Compounds; C011561:triphenylmethylphosphonium; C025042:2-(dimethylaminostyryl)-1-ethylpyridinium; D004996:Ethidium; C013289:tetraphenylphosphonium | 10.1099/00221287-132-11-3187 | [] | false | eng | J Gen Microbiol | 0375371 | 0022-1287 | England | [] | "2024-08-13T08:46:10.019100Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Nutritional variation in Escherichia coli. | 132(11) | 3231-4 | Nutritional tests were carried out on 62 strains of Escherichia coli as part of a study on the genetic basis of natural nutritional variation. The ability of these strains to utilize 84 compounds as carbon, nitrogen and carbon plus nitrogen sources was tested using an auxanographic method. The tests revealed polymorphic characters which are suitable for genetic analysis. Very few of these strains grew on the amino acids classified as 'essential' for humans. | Journal of general microbiology | [
{
"affiliation": "",
"forename": "D K",
"identifier": "",
"initials": "DK",
"lastname": "Olukoya"
}
] | 1986-11 | 3305783 | D000596:Amino Acids / Q000378:metabolism; D002244:Carbon / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D005838:Genotype; D009584:Nitrogen / Q000378:metabolism | D016428:Journal Article | D000596:Amino Acids; D002244:Carbon; D009584:Nitrogen | 10.1099/00221287-132-11-3231 | [] | false | eng | J Gen Microbiol | 0375371 | 0022-1287 | England | [] | "2024-08-13T08:46:10.019826Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
The cellular location of proteases in Candida albicans. | 132(11) | 3235-8 | Vacuoles prepared from yeast cells of Candida albicans were enriched in proteinase ycaB (EC 3.4.21.48) but not in aminopeptidase or beta-glucosidase. Proteinase ycaB, assayed in situ, increased 1.5-fold during starvation whereas aminopeptidase activity decreased by 25%. Proteinase ycaB increased a further 1.5-fold during germ-tube formation. | Journal of general microbiology | [
{
"affiliation": "",
"forename": "P C",
"identifier": "",
"initials": "PC",
"lastname": "Farley"
},
{
"affiliation": "",
"forename": "M G",
"identifier": "",
"initials": "MG",
"lastname": "Shepherd"
},
{
"affiliation": "",
"forename": "P A",
"identifier": "",
"initials": "PA",
"lastname": "Sullivan"
}
] | 1986-11 | 3305784 | D000626:Aminopeptidases / Q000378:metabolism; D002176:Candida albicans / Q000201:enzymology*; D009024:Morphogenesis; D010447:Peptide Hydrolases / Q000378:metabolism* | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D010447:Peptide Hydrolases; D000626:Aminopeptidases | 10.1099/00221287-132-11-3235 | [] | false | eng | J Gen Microbiol | 0375371 | 0022-1287 | England | [] | "2024-08-13T08:46:10.020761Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Monoclonal antibodies demonstrate heterogeneity in the G glycoprotein of prototype strains and clinical isolates of respiratory syncytial virus. | 22(4) | 345-56 | In order to study variation among prototype strains and clinical isolates of respiratory syncytial (RS) virus, four prototype strains (Long, A2, CH18537, 9320) were used to produce monoclonal antibodies to this virus. The majority of monoclonals reacted with all four prototype strains by fluorescent antibody staining. Among the non-cross-reacting monoclonals, five additional patterns of reactivity with the prototype strains were recognized. Fourteen monoclonals, including ones representative of each of the patterns of reactivity with the prototype strains, were selected to use for typing prototype strains and community isolates. All 14 were found by immunoprecipitation to recognize the RS virus G glycoprotein. These monoclonals could uniquely identify each of the prototype strains. In addition to the antigenic differences among the prototype strains detected by the monoclonals, differences were also detected in the migration of the G glycoprotein of the prototype strains in polyacrylamide gel electrophoresis. Fluorescent antibody staining with panels of monoclonals distinguished two antigenic types among 114 isolates of RS virus recovered from children in St. Louis during the period 1981-86. The predominant type (80% of isolates) had a pattern of reactivity that resembled but differed from that of either the Long or A2 strains. The second type had a pattern of reactivity identical with that of 9320. The possible significance of this heterogeneity must be considered in developing diagnostic tests as well as active or passive immunotherapy for infections caused by RS virus. | Journal of medical virology | [
{
"affiliation": "",
"forename": "G A",
"identifier": "",
"initials": "GA",
"lastname": "Storch"
},
{
"affiliation": "",
"forename": "C S",
"identifier": "",
"initials": "CS",
"lastname": "Park"
}
] | 1987-08 | 3305785 | D000911:Antibodies, Monoclonal; D004591:Electrophoresis, Polyacrylamide Gel; D005455:Fluorescent Antibody Technique; D006023:Glycoproteins / Q000032:analysis / Q000235:genetics*; D008970:Molecular Weight; D012136:Respiratory Syncytial Viruses / Q000032:analysis / Q000235:genetics*; D019699:Thrombospondins | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't; D013487:Research Support, U.S. Gov't, P.H.S. | D000911:Antibodies, Monoclonal; D006023:Glycoproteins; D019699:Thrombospondins | 10.1002/jmv.1890220407 | [] | false | eng | J Med Virol | 7705876 | 0146-6615 | United States | [
{
"agency": "NCRR NIH HHS",
"country": "United States",
"grant_acronym": "RR",
"grant_id": "2S07RR05389-24"
}
] | "2024-08-13T08:46:10.021530Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Correlation of serum HIV antigen and antibody with clinical status in HIV-infected patients. | 22(4) | 357-63 | An enzyme immunoassay (EIA) has been developed which detects antigen(s) (Ag) of the human immunodeficiency virus (HIV) in the serum of patients with the acquired immunodeficiency syndrome (AIDS), AIDS-related complex (ARC), and patients at high risk for HIV infection. The test has a sensitivity of approximately 50 pg/ml of HIV protein. The specificity of the assay was determined with various virus infected cell lines, normal human sera/plasma, and serum from patients not known to be at risk for HIV infection. No false-positive HIV-Ag results were seen. Sera from 69% of patients with AIDS were positive for HIV-Ag as were 46% of patients with ARC and 19% of asymptomatic, HIV-antibody-positive individuals. There were significant associations between the stage of HIV infection--ie, AIDS vs ARC vs asymptomatic--and the detection of HIV-Ag in serum (p less than 0.0001) and the lack of detection of antibody to HIV core Ag (p less than 0.0001). HIV-Ag was also found in the serum of two asymptomatic antibody-negative individuals who were at high risk for AIDS and who later developed HIV antibody. The presence of HIV-Ag in sera was confirmed by an inhibition procedure. Thus, HIV-Ag can be detected in the serum of infected individuals prior to antibody production and correlates with the clinical stage of HIV infection. | Journal of medical virology | [
{
"affiliation": "",
"forename": "D A",
"identifier": "",
"initials": "DA",
"lastname": "Paul"
},
{
"affiliation": "",
"forename": "L A",
"identifier": "",
"initials": "LA",
"lastname": "Falk"
},
{
"affiliation": "",
"forename": "H A",
"identifier": "",
"initials": "HA",
"lastname": "Kessler"
},
{
"affiliation": "",
"forename": "R M",
"identifier": "",
"initials": "RM",
"lastname": "Chase"
},
{
"affiliation": "",
"forename": "B",
"identifier": "",
"initials": "B",
"lastname": "Blaauw"
},
{
"affiliation": "",
"forename": "D S",
"identifier": "",
"initials": "DS",
"lastname": "Chudwin"
},
{
"affiliation": "",
"forename": "A L",
"identifier": "",
"initials": "AL",
"lastname": "Landay"
}
] | 1987-08 | 3305786 | D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology* / Q000503:physiopathology; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis*; D002460:Cell Line; D006678:HIV / Q000302:isolation & purification*; D006801:Humans; D007124:Immunoenzyme Techniques | D016428:Journal Article | D000914:Antibodies, Viral; D000956:Antigens, Viral | 10.1002/jmv.1890220408 | [] | false | eng | J Med Virol | 7705876 | 0146-6615 | United States | [] | "2024-08-13T08:46:10.022641Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Low-dose vaccination against hepatitis B in children: one-year follow-up. | 22(4) | 387-92 | Six hundred forty-three children, negative for markers of hepatitis B virus (HBV) infections, were given three X 2-micrograms doses of Merck, Sharp and Dohme (MSD) plasma derived hepatitis B vaccine (H-B-Vax) at monthly intervals. Twelve months after the first dose of vaccine, antibody to hepatitis B surface antigen (anti-HBs) was detected in 89% of children by radioimmunoassay (RIA) and in 83% by enzyme immunoassay (EIA). Seroconversion rates and anti-HBs titres were significantly greater in 1-4-year-olds than in older children (p less than 0.01). Eighteen children with no anti-HBs or other markers of HBV at this time were given 10 micrograms of vaccine and tested one month later. Seventeen developed anti-HBs, 12 at levels consistent with an anamnestic response. Forty-nine HBV-marker-negative children seroconverted for antibody to hepatitis B core antigen (anti-HBc) in the 8-month period before or the 12-month period following vaccination. Forty-six of these children were positive for anti-HBs, and one has been confirmed as a chronic carrier of hepatitis B surface antigen (HBsAg). Three cases of clinical hepatitis B in children have been seen in the community since the vaccination programme began. Two of these were amongst the estimated 5% of children who were not vaccinated. The third was in a vaccinee and occurred 4 1/2 months after the last dose of vaccine.(ABSTRACT TRUNCATED AT 250 WORDS) | Journal of medical virology | [
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Milne"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Dimitrakakis"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Campbell"
},
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Lucas"
},
{
"affiliation": "",
"forename": "G",
"identifier": "",
"initials": "G",
"lastname": "Allwood"
},
{
"affiliation": "",
"forename": "P",
"identifier": "",
"initials": "P",
"lastname": "Goldwater"
},
{
"affiliation": "",
"forename": "N",
"identifier": "",
"initials": "N",
"lastname": "Pearce"
},
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Krugman"
}
] | 1987-08 | 3305787 | D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006386:Hemagglutination Tests; D006509:Hepatitis B / Q000453:epidemiology; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006511:Hepatitis B Antigens / Q000032:analysis*; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D011863:Radioimmunoassay; D014761:Viral Hepatitis Vaccines / Q000494:pharmacology | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens; D006512:Hepatitis B Core Antigens; D014761:Viral Hepatitis Vaccines | 10.1002/jmv.1890220412 | [] | false | eng | J Med Virol | 7705876 | 0146-6615 | United States | [] | "2024-08-13T08:46:10.025067Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Monoamine oxidase in rat and bovine endocrine tissues. | 49(4) | 1183-90 | Monoamine oxidase (MAO) was characterized in tissue homogenates from rat pancreatic islets, rat neurohypophysis and adenohypophysis, and rat and bovine adrenal medulla and adrenal cortex. Phenylethylamine was preferentially deaminated by rat pancreatic islet and bovine adrenal medulla MAO and with slight preference by rat neurohypophysis MAO, whereas 5-hydroxytryptamine was preferentially deaminated by MAO from all other endocrine tissues. Tyramine was a good substrate for all tissues. Clorgyline, a selective inhibitor of MAO-A, preferentially inhibited deamination of 5-hydroxytryptamine by all tissue homogenates, whereas deprenyl, a selective inhibitor of MAO-B, preferentially inhibited deamination of phenylethylamine. Km values for 5-hydroxytryptamine and tyramine were higher by one to two decimal powers than for phenylethylamine in homogenates from all endocrine tissues. Km values were significantly lower for 5-hydroxytryptamine and significantly higher for phenylethylamine in rat and bovine adrenal cortex than in adrenal medulla. According to these results, the contributions of MAO-B to total enzyme activity were 70% for rat pancreatic islets, 45% for rat neurohypophysis, 15% for rat adenohypophysis, 20% for rat adrenal medulla, 10% for rat adrenal cortex, 60% for bovine adrenal medulla, and 20% for bovine adrenal cortex. PC 12 cells also contained predominantly MAO-A (90%); however, an increased Km for phenylethylamine and a sensitivity of deamination of this MAO-B substrate to inhibition by clorgyline are indicators of abnormal behavior of MAO in this clonal rat pheochromocytoma cell line. | Journal of neurochemistry | [
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Lenzen"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Freisinger-Treichel"
},
{
"affiliation": "",
"forename": "U",
"identifier": "",
"initials": "U",
"lastname": "Panten"
}
] | 1987-10 | 3305788 | D000302:Adrenal Cortex / Q000201:enzymology; D000310:Adrenal Gland Neoplasms / Q000201:enzymology; D000313:Adrenal Medulla / Q000201:enzymology; D000818:Animals; D002417:Cattle; D002460:Cell Line; D004702:Endocrine Glands / Q000201:enzymology*; D005260:Female; D007515:Islets of Langerhans / Q000201:enzymology; D007700:Kinetics; D008995:Monoamine Oxidase / Q000378:metabolism*; D010673:Pheochromocytoma / Q000201:enzymology; D010903:Pituitary Gland, Anterior / Q000201:enzymology; D010904:Pituitary Gland, Posterior / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013379:Substrate Specificity; D014018:Tissue Distribution | D003160:Comparative Study; D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D008995:Monoamine Oxidase | 10.1111/j.1471-4159.1987.tb10009.x | [] | false | eng | J Neurochem | 2985190R | 0022-3042 | England | [] | "2024-08-13T08:46:10.026041Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Insulin binding and effects on pyrimidine nucleoside uptake and incorporation in cultured mouse astrocytes. | 49(4) | 1293-300 | Binding of 125I-insulin to primary cultures of differentiated mouse astrocytes was time-dependent, reaching equilibrium after 2 h at 22 degrees C, with equilibrium binding corresponding to 20.79 fmol/mg of protein, representing approximately 5,000 occupied binding sites/cell. The half-life of 125I-insulin dissociation at 22 degrees C was 2 min, with an initial dissociation rate constant of 4.12 X 10(-2) s-1. Dissociation of bound 125I-insulin was not accelerated significantly in the presence of unlabeled insulin (16.7 microM). Porcine and desoctapeptide insulins competed for specific 125I-insulin binding in a dose-dependent manner, whereas growth hormone, glucagon, and somatostatin did not. For porcine insulin, Scatchard analysis suggested multiple-affinity binding sites (high-affinity Ka = 4.92 X 10(8) M-1; low-affinity Ka = 0.95 X 10(7) M-1). After incubation with insulin (0.5 microM) for 2 h at 37 degrees C, increases above basal values of 254 +/- 23 and 189 +/- 34% for [3H]uridine uptake and incorporation, respectively, were observed. After incubation with insulin (0.5 microM) for 24 h at 37 degrees C, there were increases of 145 +/- 6% for [3H]thymidine uptake and 166 +/- 11% for thymidine incorporation. Basal and stimulated uridine and thymidine uptake and incorporation were inhibited by 50 microM dipyridamole. These studies confirm that mouse astrocytes in vitro possess specific insulin receptors and demonstrate an effect of insulin on pyrimidine nucleoside uptake and incorporation. | Journal of neurochemistry | [
{
"affiliation": "",
"forename": "W",
"identifier": "",
"initials": "W",
"lastname": "Kum"
},
{
"affiliation": "",
"forename": "C S",
"identifier": "",
"initials": "CS",
"lastname": "Cockram"
},
{
"affiliation": "",
"forename": "S Q",
"identifier": "",
"initials": "SQ",
"lastname": "Zhu"
},
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Teoh"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Vallance-Owen"
},
{
"affiliation": "",
"forename": "J D",
"identifier": "",
"initials": "JD",
"lastname": "Young"
}
] | 1987-10 | 3305789 | D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D007328:Insulin / Q000378:metabolism* / Q000494:pharmacology; D007457:Iodine Radioisotopes; D007700:Kinetics; D051379:Mice; D008813:Mice, Inbred ICR; D011972:Receptor, Insulin / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism*; D014529:Uridine / Q000378:metabolism* | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D007328:Insulin; D007457:Iodine Radioisotopes; D011972:Receptor, Insulin; D013936:Thymidine; D014529:Uridine | 10.1111/j.1471-4159.1987.tb10023.x | [] | false | eng | J Neurochem | 2985190R | 0022-3042 | England | [] | "2024-08-13T08:46:10.027316Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Arrest of proteolipid transport through the Golgi apparatus in Jimpy brain. | 16(2) | 195-204 | Immunocytochemical investigations were performed on Jimpy and control mouse brains using three specific anti-myelin proteolipids antisera: immunoaffinity purified multivalent anti-(PLP + DM-20) proteolipid antibodies, anti-C-terminal hexapeptide 271-276 and anti-tridecapeptide 117-129 antisera. The results show that oligodendrocytes and myelin sheaths in normal mouse brain are labelled to the same extent by the three specific antisera; in contrast, in Jimpy brain these cellular structures are only stained by the multivalent antibodies and the site-specific, anti-tridecapeptide antiserum. The absence of labelling with C-terminal hexapeptide antiserum in mutant brain is interpreted as the result of either a large deletion or a point mutation producing a frameshift in the C-terminal part of the sequences of the proteolipids PLP and DM-20. Furthermore, we show that this mutation prevents the normal transport of proteolipid molecules through the Golgi apparatus. The existence of a minor, extra-Golgi apparatus metabolic route for proteolipids to myelin structures is also discussed. | Journal of neurocytology | [
{
"affiliation": "",
"forename": "G",
"identifier": "",
"initials": "G",
"lastname": "Roussel"
},
{
"affiliation": "",
"forename": "N M",
"identifier": "",
"initials": "NM",
"lastname": "Neskovic"
},
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Trifilieff"
},
{
"affiliation": "",
"forename": "J C",
"identifier": "",
"initials": "JC",
"lastname": "Artault"
},
{
"affiliation": "",
"forename": "J L",
"identifier": "",
"initials": "JL",
"lastname": "Nussbaum"
}
] | 1987-04 | 3305791 | D000818:Animals; D001692:Biological Transport; D001921:Brain / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008816:Mice, Jimpy / Q000378:metabolism*; D008818:Mice, Neurologic Mutants / Q000378:metabolism*; D008854:Microscopy, Electron; D009185:Myelin Proteins / Q000378:metabolism*; D009186:Myelin Sheath / Q000378:metabolism; D009836:Oligodendroglia / Q000378:metabolism; D011510:Proteolipids / Q000378:metabolism* | D016428:Journal Article | D009185:Myelin Proteins; D011510:Proteolipids | 10.1007/BF01795303 | [] | false | eng | J Neurocytol | 0364620 | 0300-4864 | United States | [] | "2024-08-13T08:46:10.028431Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Incidence and prevalence studies in epilepsy and their methodological problems: a review. | 50(7) | 829-39 | Epidemiological studies in epilepsy have a number of specific problems, discussed here with reference to the published literature. Case ascertainment may pose difficulties because of deficiencies in patients reporting and in the diagnosis of seizures, and inherent methodological problems; the classification of epilepsy is often arbitrary and definitions variable; unsuspected selection bias may markedly influence incidence and prevalence rates. The major published incidence and prevalence studies are reviewed and the factors influencing these rates discussed. | Journal of neurology, neurosurgery, and psychiatry | [
{
"affiliation": "",
"forename": "J W",
"identifier": "",
"initials": "JW",
"lastname": "Sander"
},
{
"affiliation": "",
"forename": "S D",
"identifier": "",
"initials": "SD",
"lastname": "Shorvon"
}
] | 1987-07 | 3305790 | D004812:Epidemiologic Methods; D004827:Epilepsy / Q000145:classification / Q000453:epidemiology*; D006801:Humans | D016428:Journal Article; D016454:Review | 10.1136/jnnp.50.7.829 | [
{
"citation": "Epilepsia. 1968 Jun;9(2):77-85",
"pmid": "5247004"
},
{
"citation": "Epilepsia. 1979 Dec;20(6):613-22",
"pmid": "499114"
},
{
"citation": "Epilepsia. 1962 Jun;3:175-87",
"pmid": "13869342"
},
{
"citation": "J Neurol Neurosurg Psychiatry. 1984 Nov;47(11):1157-65",
"pmid": "6502173"
},
{
"citation": "N Engl J Med. 1965 Dec 23;273(26):1410-3",
"pmid": "5848414"
},
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] | false | eng | J Neurol Neurosurg Psychiatry | 2985191R | 0022-3050 | England | [] | "2024-08-13T08:46:10.030991Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Repeated high-dose chemotherapy followed by purged autologous bone marrow transplantation as consolidation therapy in metastatic neuroblastoma. | 5(8) | 1205-11 | Among 62 children over 1 year of age at diagnosis, who were treated for stage IV neuroblastoma, 33 entered complete remission (CR) or good partial remission (GPR) after conventional therapy and received high-dose chemotherapy (HDC) with in vitro purged autologous bone marrow transplantation (ABMT) as consolidation therapy. The HDC was a combination of carmustine (BCNU), teniposide (VM-26), and melphalan. Thirty-three patients received one course of this regimen, and 18 received two courses. At present, 16 of the 33 grafted patients are alive in continuous CR, with a median follow-up of 28 months. Toxicity of this regimen was tolerable, principally marked by bone marrow depression and gastrointestinal (GI) tract complications. Four complication-related deaths were observed. Relapse post-ABMT occurred most often in the bone marrow. Under this treatment, actuarial disease-free survival is improved compared with that observed under conventional therapy. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology | [
{
"affiliation": "",
"forename": "O",
"identifier": "",
"initials": "O",
"lastname": "Hartmann"
},
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Benhamou"
},
{
"affiliation": "",
"forename": "F",
"identifier": "",
"initials": "F",
"lastname": "Beaujean"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Kalifa"
},
{
"affiliation": "",
"forename": "O",
"identifier": "",
"initials": "O",
"lastname": "Lejars"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Patte"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Behard"
},
{
"affiliation": "",
"forename": "F",
"identifier": "",
"initials": "F",
"lastname": "Flamant"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Thyss"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Deville"
}
] | 1987-08 | 3305792 | D000008:Abdominal Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000628:therapy; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001855:Bone Marrow Diseases / Q000139:chemically induced; D016026:Bone Marrow Transplantation; D002330:Carmustine / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007223:Infant; D007239:Infections / Q000139:chemically induced; D008558:Melphalan / Q000008:administration & dosage / Q000009:adverse effects; D009447:Neuroblastoma / Q000188:drug therapy / Q000556:secondary* / Q000628:therapy; D013713:Teniposide / Q000008:administration & dosage / Q000009:adverse effects; D013899:Thoracic Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000628:therapy; D014182:Transplantation, Autologous; D014750:Vincristine / Q000008:administration & dosage | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D013713:Teniposide; D002945:Cisplatin; D008558:Melphalan; D002330:Carmustine | 10.1200/JCO.1987.5.8.1205 | [] | false | eng | J Clin Oncol | 8309333 | 0732-183X | United States | [] | "2024-08-13T08:46:10.032730Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Treatment of malignant lymphoma in 100 patients with chemotherapy, total body irradiation, and marrow transplantation. | 5(9) | 1340-7 | Between July 1970 and January 1985, 100 patients with malignant lymphoma were treated with high-dose chemoradiotherapy and bone marrow transplantation. Twenty-eight of the 100 are alive and the actuarial probability of disease-free survival 5 years from transplantation is 22%. The most common reason for treatment failure was disease recurrence, with an actuarial probability of 60%. A proportional hazards regression analysis showed that the likelihood of disease-free survival was less in those patients transplanted in resistant relapse and in those previously treated with chest radiotherapy. Neither disease histology (Hodgkin's disease, high-grade lymphoma or intermediate-grade lymphoma), nor source of marrow (syngeneic, allogeneic, or autologous) significantly influenced either disease-free survival or probability of relapse. The use of high-dose chemoradiotherapy and marrow transplantation appears to offer a better chance for long-term survival than any other form of therapy for young patients with disseminated malignant lymphoma whose disease has progressed after initial combination chemotherapy. The best results with marrow transplantation were obtained in patients transplanted in early relapse or second remission who had not received prior chest radiotherapy. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology | [
{
"affiliation": "",
"forename": "F R",
"identifier": "",
"initials": "FR",
"lastname": "Appelbaum"
},
{
"affiliation": "",
"forename": "K M",
"identifier": "",
"initials": "KM",
"lastname": "Sullivan"
},
{
"affiliation": "",
"forename": "C D",
"identifier": "",
"initials": "CD",
"lastname": "Buckner"
},
{
"affiliation": "",
"forename": "R A",
"identifier": "",
"initials": "RA",
"lastname": "Clift"
},
{
"affiliation": "",
"forename": "H J",
"identifier": "",
"initials": "HJ",
"lastname": "Deeg"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Fefer"
},
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Hill"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Mortimer"
},
{
"affiliation": "",
"forename": "P E",
"identifier": "",
"initials": "PE",
"lastname": "Neiman"
},
{
"affiliation": "",
"forename": "J E",
"identifier": "",
"initials": "JE",
"lastname": "Sanders"
}
] | 1987-09 | 3305793 | D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014916:Whole-Body Irradiation | D016428:Journal Article; D013487:Research Support, U.S. Gov't, P.H.S. | D003520:Cyclophosphamide | 10.1200/JCO.1987.5.9.1340 | [] | false | eng | J Clin Oncol | 8309333 | 0732-183X | United States | [
{
"agency": "NCI NIH HHS",
"country": "United States",
"grant_acronym": "CA",
"grant_id": "CA 15704"
},
{
"agency": "NCI NIH HHS",
"country": "United States",
"grant_acronym": "CA",
"grant_id": "CA 18029"
},
{
"agency": "NCI NIH HHS",
"country": "United States",
"grant_acronym": "CA",
"grant_id": "CA 26828"
}
] | "2024-08-13T08:46:10.034332Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Allogeneic bone marrow transplantation for acute lymphoblastic leukemia in remission: prolonged survival associated with acute graft-versus-host disease. | 5(9) | 1348-55 | Forty remission patients with high-risk acute lymphoblastic leukemia (ALL) underwent matched allogenic bone marrow transplantation (BMT) following preparation with cyclophosphamide and fractionated total body irradiation (TBI). As of March 1987, the median follow-up is more than 3 1/2 years. Thirteen patients are alive (11 relapse free) between 2 and 4 1/2 years post-BMT. Neither age, sex, remission number, prior extramedullary leukemia, nor WBC at diagnosis of ALL was statistically significant as a predictor of relapse-free survival. The development of acute graft-v-host disease (GVHD) in 17 patients was found, with time-dependent Cox regression analysis, to be associated with a significant reduction in post-BMT relapse risk (P = .04) and improved disease-free survival (P = .11). A prospective, randomized trial of maintenance chemotherapy with oral methotrexate and mercaptopurine did not demonstrate improvement in relapse risk or survival for those assigned maintenance chemotherapy (P = .7). These results suggest that allogeneic BMT can result in extended relapse-free survival for some patients with high-risk ALL. More effective preparative chemoradiotherapy and exploitation of the apparent graft-v-leukemia effect may be useful in future trials. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology | [
{
"affiliation": "",
"forename": "D J",
"identifier": "",
"initials": "DJ",
"lastname": "Weisdorf"
},
{
"affiliation": "",
"forename": "M E",
"identifier": "",
"initials": "ME",
"lastname": "Nesbit"
},
{
"affiliation": "",
"forename": "N K",
"identifier": "",
"initials": "NK",
"lastname": "Ramsay"
},
{
"affiliation": "",
"forename": "W G",
"identifier": "",
"initials": "WG",
"lastname": "Woods"
},
{
"affiliation": "",
"forename": "A I",
"identifier": "",
"initials": "AI",
"lastname": "Goldman"
},
{
"affiliation": "",
"forename": "T H",
"identifier": "",
"initials": "TH",
"lastname": "Kim"
},
{
"affiliation": "",
"forename": "D D",
"identifier": "",
"initials": "DD",
"lastname": "Hurd"
},
{
"affiliation": "",
"forename": "P B",
"identifier": "",
"initials": "PB",
"lastname": "McGlave"
},
{
"affiliation": "",
"forename": "J H",
"identifier": "",
"initials": "JH",
"lastname": "Kersey"
}
] | 1987-09 | 3305794 | D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012074:Remission Induction | D016430:Clinical Trial; D016428:Journal Article; D016449:Randomized Controlled Trial; D013485:Research Support, Non-U.S. Gov't; D013487:Research Support, U.S. Gov't, P.H.S. | 10.1200/JCO.1987.5.9.1348 | [] | false | eng | J Clin Oncol | 8309333 | 0732-183X | United States | [
{
"agency": "NCI NIH HHS",
"country": "United States",
"grant_acronym": "CA",
"grant_id": "CA07306"
},
{
"agency": "NCI NIH HHS",
"country": "United States",
"grant_acronym": "CA",
"grant_id": "CA21737"
}
] | "2024-08-13T08:46:10.036525Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
5-Fluorouracil and folinic acid in the treatment of metastatic colorectal cancer. | 5(9) | 1492-3 | Journal of clinical oncology : official journal of the American Society of Clinical Oncology | [
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Erlichman"
},
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Fine"
}
] | 1987-09 | 3305796 | D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use* | D016430:Clinical Trial; D003160:Comparative Study; D016428:Journal Article | D002955:Leucovorin; D005472:Fluorouracil | 10.1200/JCO.1987.5.9.1492 | [] | false | eng | J Clin Oncol | 8309333 | 0732-183X | United States | [] | "2024-08-13T08:46:10.037324Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
An EORTC Gastrointestinal Group phase III evaluation of combinations of methyl-CCNU, 5-fluorouracil, and adriamycin in advanced gastric cancer. | 5(9) | 1387-93 | In a prospective phase III multicenter trial, 189 patients with advanced measurable and nonmeasurable gastric cancer were randomized to receive 5-fluorouracil (5-FU) combined with Adriamycin (FA) or FA plus methyl-CCNU (MeFA). The response rate in patients with measurable disease was 10% (three of 29), and 18% (five of 28), respectively. No difference in the duration of survival was detected (P = .14; log rank test). Median survivals were 21 and 32 weeks, respectively. Toxicity was moderate, but there have been two toxic deaths among the patients who received FA. Because of the low response rate and the short survival, neither regimen can be recommended for the treatment of advanced gastric cancer. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology | [
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Lacave"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Wils"
},
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Bleiberg"
},
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Diaz-Rubio"
},
{
"affiliation": "",
"forename": "N",
"identifier": "",
"initials": "N",
"lastname": "Duez"
},
{
"affiliation": "",
"forename": "O",
"identifier": "",
"initials": "O",
"lastname": "Dalesio"
}
] | 1987-09 | 3305795 | D000230:Adenocarcinoma / Q000188:drug therapy; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004317:Doxorubicin / Q000008:administration & dosage*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009607:Nitrosourea Compounds / Q000008:administration & dosage*; D011446:Prospective Studies; D011897:Random Allocation; D012673:Semustine / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000188:drug therapy* | D016430:Clinical Trial; D003160:Comparative Study; D016428:Journal Article; D016449:Randomized Controlled Trial; D013487:Research Support, U.S. Gov't, P.H.S. | D009607:Nitrosourea Compounds; D012673:Semustine; D004317:Doxorubicin; D005472:Fluorouracil | 10.1200/JCO.1987.5.9.1387 | [] | false | eng | J Clin Oncol | 8309333 | 0732-183X | United States | [
{
"agency": "NCI NIH HHS",
"country": "United States",
"grant_acronym": "CA",
"grant_id": "5UIOCA11488-17"
}
] | "2024-08-13T08:46:10.038507Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Monoclonal antibodies specific for fixative-modified aspartate: immunocytochemical localization in the rat CNS. | 7(9) | 2639-50 | Aspartate is a putative excitatory amino acid neurotransmitter that is widely distributed in the CNS. To study its distribution, monoclonal antibodies were produced against beta-L-aspartyl-L-aspartate (beta-Asp-Asp) conjugated to keyhole limpet hemocyanin (KLH) using glutaraldehyde-borohydride. Three monoclonal antibodies, Asp1-3, were obtained with high degrees of selectivity for aldehyde-fixed aspartate. The immunocytochemical staining pattern of rat CNS was found to be similar for all 3 antibodies but differed in some regions from staining patterns produced by Glu1, a monoclonal antibody with high selectivity for a form of amide-linked glutamate. Tissue staining produced by Asp1-3 could be inhibited using aspartate conjugated to carrier proteins. Staining by Asp1 and Asp2 was also inhibited by free small molecules containing aspartate. Specificity of the 3 antibodies was evaluated by enzyme-linked immunoassay (ELISA) as follows: (1) reactivity of antibodies for conjugates of small molecules coated on ELISA plates; (2) ability of free small molecules to inhibit reactivity of antibodies for beta-Asp-Asp/KLH coated on ELISA plates; and (3) ability of conjugates to inhibit reactivity of antibodies for beta-Asp-Asp/KLH coated on ELISA plates. In all 3 types of assays, Asp1 and Asp2 displayed strong reactivity for small molecules and conjugates containing aspartate and little reactivity for small molecules and conjugates containing glutamate or GABA. Asp3 was highly reactive with conjugates containing aspartate using both directed and inhibition ELISA assays. For all 3 antibodies the precise staining pattern varied with the fixative used. Following glutaraldehyde fixation, dense immunocytochemical staining was observed in cerebral cortical neurons, some cerebellar granule cells, hippocampal pyramidal cells, and neurons of the inferior olivary nucleus. In addition, some putative GABAergic neurons, e.g., cerebellar basket and stellate cells, appeared to be stained. In general, acrolein fixation resulted in a more selective staining pattern in the CNS. For example, putative GABAergic neurons were no longer immunoreactive nor were hippocampal pyramidal cells. | The Journal of neuroscience : the official journal of the Society for Neuroscience | [
{
"affiliation": "",
"forename": "J E",
"identifier": "",
"initials": "JE",
"lastname": "Madl"
},
{
"affiliation": "",
"forename": "A J",
"identifier": "",
"initials": "AJ",
"lastname": "Beitz"
},
{
"affiliation": "",
"forename": "R L",
"identifier": "",
"initials": "RL",
"lastname": "Johnson"
},
{
"affiliation": "",
"forename": "A A",
"identifier": "",
"initials": "AA",
"lastname": "Larson"
}
] | 1987-09 | 3305797 | D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D001224:Aspartic Acid / Q000276:immunology*; D002490:Central Nervous System / Q000032:analysis*; D005404:Fixatives; D006651:Histocytochemistry; D007124:Immunoenzyme Techniques; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D014018:Tissue Distribution | D016428:Journal Article; D013486:Research Support, U.S. Gov't, Non-P.H.S.; D013487:Research Support, U.S. Gov't, P.H.S. | D000911:Antibodies, Monoclonal; D005404:Fixatives; D001224:Aspartic Acid | [] | false | eng | J Neurosci | 8102140 | 0270-6474 | United States | [
{
"agency": "NIDCR NIH HHS",
"country": "United States",
"grant_acronym": "DE",
"grant_id": "DE 06682"
},
{
"agency": "NINDS NIH HHS",
"country": "United States",
"grant_acronym": "NS",
"grant_id": "NS 17407"
},
{
"agency": "NINDS NIH HHS",
"country": "United States",
"grant_acronym": "NS",
"grant_id": "NS 19208"
}
] | "2024-08-13T08:46:10.039555Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Light and electron microscopic localization of a cell surface antigen (NG2) in the rat cerebellum: association with smooth protoplasmic astrocytes. | 7(9) | 2711-20 | Immunofluorescence and immunoperoxidase techniques were used to localize a cell surface chondroitin-sulfate proteoglycan antigen, termed NG2, in the developing and adult rat cerebellum. In the adult, both polyclonal and monoclonal anti-NG2 antibodies labeled cells throughout the cerebellar cortex, with the labeled cells being especially prominent in the molecular layer. The labeled cells had small, irregularly shaped cell bodies from which thin highly branched processes radiated in a stellate array. The NG2-labeled cells were not labeled with antibodies against glial fibrillary acidic protein (GFAP), vimentin, or S-100 protein, intracellular markers for astrocytes. However, electron microscopic immunocytochemical analysis of NG2 immunoreactive cells revealed a cell morphology consistent with that of protoplasmic astrocytes. Labeled cell bodies contained a thin rim of organelle-poor cytoplasm surrounding a euchromatic nucleus. Thick processes originating from the cell soma tapered to form thin branches with highly irregular surface contours that extended between adjacent neuronal elements. The labeled processes did not form synapses in the neuropil, and no synaptic profiles onto anti-NG2-labeled cell bodies or processes were observed. Thus, we conclude that the NG2 antigen is a cell surface marker for a class of smooth protoplasmic astrocytes. Immunoreactive cells were seen in the developing cerebellum beginning at embryonic day 16. The number of labeled cells increased during the early stages of cerebellar development, reaching a peak at about postnatal day (PND) 4 or 5 and declining thereafter. In the developing cerebellum, labeled cells lying within the forming molecular layer resembled the cells seen in the adult, whereas cells lying deeper within the folia had an immature appearance with fewer processes and less branching. This apparent gradient of morphological maturation suggests that an interaction with parallel fibers in the developing molecular layer may play a role in the terminal cytodifferentiation of the NG2-labeled smooth protoplasmic astrocytes. | The Journal of neuroscience : the official journal of the Society for Neuroscience | [
{
"affiliation": "",
"forename": "J M",
"identifier": "",
"initials": "JM",
"lastname": "Levine"
},
{
"affiliation": "",
"forename": "J P",
"identifier": "",
"initials": "JP",
"lastname": "Card"
}
] | 1987-09 | 3305798 | D000818:Animals; D000941:Antigens / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D001253:Astrocytes / Q000648:ultrastructure*; D002531:Cerebellum / Q000648:ultrastructure*; D005455:Fluorescent Antibody Technique; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D011509:Proteoglycans; D051381:Rats; D009418:S100 Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis | D016428:Journal Article; D013487:Research Support, U.S. Gov't, P.H.S. | D000941:Antigens; D000954:Antigens, Surface; D005904:Glial Fibrillary Acidic Protein; D011509:Proteoglycans; D009418:S100 Proteins; D014746:Vimentin; C030607:chondroitin sulfate proteoglycan 4 | [] | false | eng | J Neurosci | 8102140 | 0270-6474 | United States | [
{
"agency": "NINDS NIH HHS",
"country": "United States",
"grant_acronym": "NS",
"grant_id": "NS 19714"
},
{
"agency": "NINDS NIH HHS",
"country": "United States",
"grant_acronym": "NS",
"grant_id": "NS 21198"
}
] | "2024-08-13T08:46:10.041460Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Bipotential glial precursor cells of the optic nerve express the NG2 proteoglycan. | 7(9) | 2737-44 | We have studied the expression of the NG2 chondroitin sulfate proteoglycan on bipotential glial precursor cells in cultures of postnatal rat optic nerve. Purified populations of these precursor cells were prepared by panning dissociated optic nerve cells on dishes coated with monoclonal A2B5 antibody. Using immunofluorescence double staining, we found that NG2 was present on almost 95% of the purified A2B5+ precursor cells. The NG2 core protein from optic nerve cells was identified by immune precipitation and PAGE and was found to be identical to the 300,000 Da NG2 core protein from a clonal rat cell line B49. Over a culture period of 5 d in medium containing 10% fetal calf serum, more than 80% of the NG2+ precursor cells acquired the glial fibrillary acidic protein (GFAP), an astrocyte-specific marker. Under these conditions, fewer than 10% of the NG2+ cells expressed galactocerebroside (GC), an oligodendrocyte-specific marker. These GFAP+GC- type II astrocytes continued to express the NG2 antigen for up to 10 d in culture. During a 5 d culture period in hormonally supplemented, serum-free medium, fewer than 15% of the NG2+ cells expressed GFAP, while up to 40% expressed GC. The NG2 antigen continued to be expressed for only a short period of time by these GFAP-GC+ oligodendrocytes, so that mature oligodendrocytes in the cultures became NG2-. These results support our previous suggestion that the NG2 antigen is found on a class of neural cells that can differentiate along more than one pathway. | The Journal of neuroscience : the official journal of the Society for Neuroscience | [
{
"affiliation": "",
"forename": "W B",
"identifier": "",
"initials": "WB",
"lastname": "Stallcup"
},
{
"affiliation": "",
"forename": "L",
"identifier": "",
"initials": "L",
"lastname": "Beasley"
}
] | 1987-09 | 3305800 | D000818:Animals; D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis*; D001253:Astrocytes / Q000032:analysis; D002460:Cell Line; D002531:Cerebellum / Q000166:cytology; D004591:Electrophoresis, Polyacrylamide Gel; D005455:Fluorescent Antibody Technique; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006651:Histocytochemistry; D009457:Neuroglia / Q000166:cytology*; D009900:Optic Nerve / Q000166:cytology*; D011509:Proteoglycans; D051381:Rats; D011919:Rats, Inbred Strains | D016428:Journal Article; D013487:Research Support, U.S. Gov't, P.H.S. | D000911:Antibodies, Monoclonal; D000941:Antigens; D005904:Glial Fibrillary Acidic Protein; D011509:Proteoglycans; C030607:chondroitin sulfate proteoglycan 4 | [] | false | eng | J Neurosci | 8102140 | 0270-6474 | United States | [
{
"agency": "NINDS NIH HHS",
"country": "United States",
"grant_acronym": "NS",
"grant_id": "NS 21990"
}
] | "2024-08-13T08:46:10.042439Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Plasticity of developing cerebellar cells in vitro studied with antibodies against the NG2 antigen. | 7(9) | 2721-31 | The NG2 antigen, a chondroitin-sulfate proteoglycan, is a cell surface marker for a class of smooth protoplasmic astrocytes found throughout the brain and at high frequency in the cerebellar molecular layer (Levine and Card, 1987). To study the development of the cerebellar astrocytes at the level of the single cell, we have analyzed the distribution of the NG2 antigen by indirect immunofluorescence in dissociated cell cultures prepared from postnatal cerebella and compared that distribution to the distribution of several other cell surface and intracellular antigens that identify specific cell types in cultures of nervous tissue. When cerebellar cells from 5 d rat pups were grown in a medium containing 10% fetal calf serum, the NG2-labeled cells, which constituted 0.1-1.0% of the total glial cells present, contained glial fibrillary acidic protein (GFAP)-immunoreactive filaments and bound monoclonal antibody A2B5, a surface marker for neurons and some astrocytes. Approximately 30% of the NG2-labeled cells were also labeled with tetanus toxin, an additional surface marker for neurons and immature astrocytes. Less than 2% of the cells were labeled with antibodies against galactocerebroside or with monoclonal antibody O1, both of which are surface markers for oligodendrocytes. About half the NG2-labeled cells exhibited high-affinity uptake of 3H-GABA, and this uptake was partially inhibited by both beta-alanine and DABA. Thus, the NG2 antigen is a cell surface marker for a subpopulation of the type II or fibrous astrocytes present in the cultures. When the cerebellar cells were grown in a chemically defined, serum-free medium, the NG2-labeled cells had a stellate morphology and between 50-60% of the cells bound tetanus toxin. Although almost all the cells bound antibody A2B5, less than 5% of the cells expressed either of the oligodendrocyte surface markers or GFAP immunoreactivity. As was the case with cells grown in serum-containing medium, 60% of the NG2-labeled cells had high-affinity uptake of 3H-GABA. However, this uptake was inhibited by DABA but not by beta-alanine. This phenotype may be the in vitro analog of the NG2-labeled, filament-lacking, smooth protoplasmic astrocytes identified in the intact adult cerebellum. The expression of these 2 phenotypes could be reversed by switching the tissue culture medium within 5 d of plating the cells. These results demonstrate that the in vitro environment can influence the phenotypic properties expressed by developing cerebellar astrocytes and suggest that smooth protoplasmic astrocytes may be developmentally related to glial cells of the O-2A lineage. | The Journal of neuroscience : the official journal of the Society for Neuroscience | [
{
"affiliation": "",
"forename": "J M",
"identifier": "",
"initials": "JM",
"lastname": "Levine"
},
{
"affiliation": "",
"forename": "W B",
"identifier": "",
"initials": "WB",
"lastname": "Stallcup"
}
] | 1987-09 | 3305799 | D000818:Animals; D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D002531:Cerebellum / Q000254:growth & development* / Q000648:ultrastructure; D046508:Culture Techniques; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D008858:Microscopy, Phase-Contrast; D010641:Phenotype; D011509:Proteoglycans; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000378:metabolism | D016428:Journal Article; D013487:Research Support, U.S. Gov't, P.H.S. | D000911:Antibodies, Monoclonal; D000941:Antigens; D000954:Antigens, Surface; D005904:Glial Fibrillary Acidic Protein; D011509:Proteoglycans; C030607:chondroitin sulfate proteoglycan 4; D005680:gamma-Aminobutyric Acid | [] | false | eng | J Neurosci | 8102140 | 0270-6474 | United States | [
{
"agency": "PHS HHS",
"country": "United States",
"grant_acronym": "",
"grant_id": "21198"
},
{
"agency": "PHS HHS",
"country": "United States",
"grant_acronym": "",
"grant_id": "21990"
}
] | "2024-08-13T08:46:10.043705Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Distribution of synaptic specializations along isolated motor units formed in Xenopus nerve-muscle cultures. | 7(9) | 2849-61 | The capacity of individual muscle cells and neurons to establish synaptic specializations along the entire extent of their neurite-muscle contacts was assessed in culture. Spinal cord neurons derived from embryos of Xenopus laevis were plated at low density in cultures of Xenopus myotomal muscle cells in order to obtain isolated motor units whose neuron and muscle cells were not contacted by any other neuron. These isolated motor units were examined for localization of acetylcholine receptors (AChRs) after staining with fluorescent alpha-bungarotoxin and, in some cases, for localization of a synaptic vesicle antigen by immunofluorescence. The neurite-muscle contacts formed by competent neurons exhibited discontinuous sites of AChR localization occupying about 25% of the contact length as compared with 2% for incompetent neurons. Competent neurons, unlike incompetent ones, established these neurite-associated receptor patches (NARPs) on virtually all the muscle cells they contacted and functionally innervated them. These and other observations on the distribution of NARPs throughout the isolated motor units indicate that the capacity of competent neurons to establish NARPs extends to the limits of growth of most if not all of their neurites, that this capacity is least in the most proximal portions of initial neuritic segments, and that the overall capacity of muscle cells to generate NARPs can be saturated by long lengths of neurite-muscle contact. The results also suggest that even in the absence of competitive interactions between neurons there are spatial discontinuities in neuritic action and/or muscle response during the establishment of NARPs. Synaptic vesicle antigen patches (SVAPs) occurred along the neuritic arbor of all neurons, but their distribution in competent neurons (those which established NARPs) and in incompetent ones differed. For competent neurons the percentage of neurite length occupied by SVAPs was 4.8-fold greater on muscle cells than off, whereas the corresponding value for incompetent neurons was only 1.5-fold. This large preferential localization of SVAPs along neurite-muscle contacts of competent neurons was further associated with a colocalization of SVAPs and NARPs that was greater than predicted by chance. These results suggest that muscle cells are much more effective in influencing the distribution of synaptic vesicles along the neuritic arbor of competent neurons than along the arbor of incompetent neurons and that this influence is greatest at sites of postsynaptic differentiation.(ABSTRACT TRUNCATED AT 400 WORDS) | The Journal of neuroscience : the official journal of the Society for Neuroscience | [
{
"affiliation": "",
"forename": "M W",
"identifier": "",
"initials": "MW",
"lastname": "Cohen"
},
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Rodriguez-Marin"
},
{
"affiliation": "",
"forename": "E M",
"identifier": "",
"initials": "EM",
"lastname": "Wilson"
}
] | 1987-09 | 3305801 | D000818:Animals; D002038:Bungarotoxins / Q000032:analysis; D002478:Cells, Cultured; D004558:Electric Stimulation; D006651:Histocytochemistry; D008858:Microscopy, Phase-Contrast; D009046:Motor Neurons / Q000502:physiology*; D009132:Muscles / Q000294:innervation*; D009474:Neurons / Q000502:physiology; D011950:Receptors, Cholinergic / Q000032:analysis; D013116:Spinal Cord / Q000166:cytology; D013569:Synapses / Q000502:physiology*; D013572:Synaptic Vesicles / Q000648:ultrastructure; D014982:Xenopus laevis | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D002038:Bungarotoxins; D011950:Receptors, Cholinergic | [] | false | eng | J Neurosci | 8102140 | 0270-6474 | United States | [] | "2024-08-13T08:46:10.044786Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Induction of a neural phenotype in a serotonergic endocrine cell derived from the neural crest. | 7(9) | 2874-83 | The thyroid parafollicular cell is an endocrine cell derived from the neural crest that stores 5-hydroxytryptamine (5-HT). In common with serotonergic neurons, but in contrast to 5-HT-storing cells that are not neurectodermal derivatives, parafollicular cells also contain a specific 5-HT binding protein. Despite this similarity to serotonergic neurons, parafollicular cells in situ were found to express an endocrine phenotype with few neural characteristics. Thus, the cells costore 5-HT with calcitonin, not calcitonin gene-related peptide (CGRP), which is the product of the calcitonin gene expressed in neurons, and they do not contain neurofilaments. The ability of adult parafollicular cells to respond to microenvironmental perturbations by expressing neuronal characteristics was examined. Sheep thyroid glands were dissociated, and parafollicular cells were purified by affinity chromatography. The purified parafollicular cells were grown in culture on a variety of substrates in the presence or absence of the beta subunit of nerve growth factor (beta-NGF). Parafollicular cells survived in culture for at least a week but retained a roughly spherical shape. Nevertheless, a subset of the cultured parafollicular cells began to display CGRP immunoreactivity. The addition of beta-NGF to the cultured parafollicular cells induced a number of them to extend neurites and increased the proportion of cells in which CGRP immunoreactivity could be found. Neurite-bearing parafollicular cells appeared not to survive for more than 2 d. While their survival was not enhanced when they were grown on collagen, polylysine, laminin, or reconstituted basal lamina, parafollicular cells that had extended neurites in response to beta-NGF survived for at least a week when cocultured with an explant of aneuronal chick hindgut. The effect of the gut was local and only those neurite-bearing parafollicular cells that were growing in direct contact with the explant survived. The thyroid parafollicular cell therefore resembles another crest-derived endocrine cell, the adrenal chromaffin cell, in being able to manifest neural properties in culture. For the parafollicular cell these neural properties include the processing of RNA encoded by the calcitonin gene to express CGRP and neurite outgrowth in response to beta-NGF. | The Journal of neuroscience : the official journal of the Society for Neuroscience | [
{
"affiliation": "",
"forename": "J M",
"identifier": "",
"initials": "JM",
"lastname": "Barasch"
},
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Mackey"
},
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Tamir"
},
{
"affiliation": "",
"forename": "E A",
"identifier": "",
"initials": "EA",
"lastname": "Nunez"
},
{
"affiliation": "",
"forename": "M D",
"identifier": "",
"initials": "MD",
"lastname": "Gershon"
}
] | 1987-09 | 3305802 | D000818:Animals; D002116:Calcitonin / Q000032:analysis / Q000235:genetics; D015740:Calcitonin Gene-Related Peptide; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D009414:Nerve Growth Factors / Q000032:analysis; D009432:Neural Crest / Q000166:cytology*; D009474:Neurons / Q000166:cytology*; D009479:Neuropeptides / Q000032:analysis / Q000235:genetics; D012701:Serotonin; D012756:Sheep; D013961:Thyroid Gland / Q000166:cytology | D016428:Journal Article; D013487:Research Support, U.S. Gov't, P.H.S. | D009414:Nerve Growth Factors; D009479:Neuropeptides; D012701:Serotonin; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide | [] | false | eng | J Neurosci | 8102140 | 0270-6474 | United States | [
{
"agency": "NIADDK NIH HHS",
"country": "United States",
"grant_acronym": "AM",
"grant_id": "AM 19743"
},
{
"agency": "NINDS NIH HHS",
"country": "United States",
"grant_acronym": "NS",
"grant_id": "NS 07062"
},
{
"agency": "NINDS NIH HHS",
"country": "United States",
"grant_acronym": "NS",
"grant_id": "NS 12969"
}
] | "2024-08-13T08:46:10.046928Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Measurement of effective renal plasma flow: a comparison of methods. | 28(9) | 1393-400 | We have compared two in vitro methods and three variations of kidney background (BG) subtraction within a gamma camera method (41 examinations, 31 patients) for determination of effective renal plasma flow (ERPF) using 131I orthoiodohippurate (OIH). Method I: plasma samples at 20 and 45 min after OIH injection, ERPF = dose X slope/intercept; Method II: 45-min plasma sample, ERPF = -51.1 + 8.21x + 0.019x2, x = dose/45-min plasma activity/I. Individual kidney and total ERPF were determined from gamma camera (GC) methods using renal uptake 1-2 min after injection. All methods were compared against Method I (previously validated against paraaminohippurate (PAH) clearances). Method II, which requires one blood sample is more accurate than GC methods. GC methods are insensitive to operator variability in placement of renal and BG regions of interest. They may be useful to follow changes in relative or total ERPF, but accurate depth correction of renal data is suggested. In vitro, blood sample-based methods are more accurate. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine | [
{
"affiliation": "",
"forename": "E J",
"identifier": "",
"initials": "EJ",
"lastname": "Fine"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Axelrod"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Gorkin"
},
{
"affiliation": "",
"forename": "K",
"identifier": "",
"initials": "K",
"lastname": "Saleemi"
},
{
"affiliation": "",
"forename": "M D",
"identifier": "",
"initials": "MD",
"lastname": "Blaufox"
}
] | 1987-09 | 3305805 | D006801:Humans; D007465:Iodohippuric Acid; D011866:Radioisotope Renography / Q000379:methods; D012079:Renal Circulation; D013382:Subtraction Technique | D003160:Comparative Study; D016428:Journal Article | D007465:Iodohippuric Acid | [] | false | eng | J Nucl Med | 0217410 | 0161-5505 | United States | [] | "2024-08-13T08:46:10.047902Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Single-dose captopril scintigraphy in the diagnosis of renovascular hypertension. | 28(9) | 1383-92 | Renal scintigraphy with [99mTc]diethylenetriaminepentaacetic acid (DTPA) and/or sodium-iodine-131-o-iodohippurate (HIP) was performed before and after an oral dose of captopril (50 mg) in 18 patients with renovascular hypertension (RVH) due to renal artery stenosis (RAS) and 18 controls. In every patient with RVH, captopril induced, enhanced or sustained abnormal findings on HIP scintigraphy depending on the degree of RAS. With DTPA scintigraphy, renal function decreased after captopril in ten kidneys with RVH-related RAS and adequate baseline renal function, but this phenomenon was not evident in 11 kidneys with RVH and poor renal function. Captopril did not influence HIP or DTPA studies of kidneys with patent renal arteries (patients after successful renal angioplasty, patients with essential hypertension, contralateral kidneys of patients with unilateral RVH) or ipsilateral kidneys with mild and subcritical (less than 60%) RAS in patients without hypertension and/or normal renal vein renin activity. When HIP and DTPA scintigraphy were compared in the same patients, HIP demonstrated greater sensitivity and specificity than DTPA, particularly in patients with poor renal function. HIP scintigraphy before and after a single dose of captopril may provide a rapid sensitive and minimally invasive test for screening patients with hypertension. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine | [
{
"affiliation": "",
"forename": "G N",
"identifier": "",
"initials": "GN",
"lastname": "Sfakianakis"
},
{
"affiliation": "",
"forename": "J J",
"identifier": "",
"initials": "JJ",
"lastname": "Bourgoignie"
},
{
"affiliation": "",
"forename": "D",
"identifier": "",
"initials": "D",
"lastname": "Jaffe"
},
{
"affiliation": "",
"forename": "G",
"identifier": "",
"initials": "G",
"lastname": "Kyriakides"
},
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Perez-Stable"
},
{
"affiliation": "",
"forename": "R C",
"identifier": "",
"initials": "RC",
"lastname": "Duncan"
}
] | 1987-09 | 3305804 | D000284:Administration, Oral; D002216:Captopril / Q000008:administration & dosage; D006801:Humans; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging*; D007465:Iodohippuric Acid; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011866:Radioisotope Renography / Q000379:methods*; D016284:Technetium Tc 99m Pentetate | D003160:Comparative Study; D016428:Journal Article | D009942:Organometallic Compounds; D007465:Iodohippuric Acid; D004369:Pentetic Acid; D002216:Captopril; D016284:Technetium Tc 99m Pentetate | [] | false | eng | J Nucl Med | 0217410 | 0161-5505 | United States | [] | "2024-08-13T08:46:10.048987Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Technetium-99m DTPA uptake and transit in bone: effect on blood clearance in rabbits. | 28(9) | 1461-4 | The purpose of this study is to explain the initial "plateau" distribution of [99mTc]DTPA in the forearm found when using serial external counting for kidney clearance measurements. A study by a MIRD task group, McAfee et al. 1979 (1), measured the biologic distribution of [99mTc]DTPA(Sn) in most body tissues but omitted bone, which we believe is a major contributor to this initial "plateau". Using MIRD criteria, measurements were carried out on rabbit humeri and these were compared with results obtained from human subjects. It would appear that initial accumulation of the compound by interstitial bone is the reason for the "plateau" and explains why blood sampling for GFR studies should not be undertaken over the first 2 hr. In addition, the results of this study provide valuable information relevant to bone perfusion studies and the biologic distribution and concentration of i.v. administered drugs during the first 2 hr postinjection. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine | [
{
"affiliation": "",
"forename": "W F",
"identifier": "",
"initials": "WF",
"lastname": "Sampson"
}
] | 1987-09 | 3305806 | D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D006801:Humans; D006811:Humerus / Q000378:metabolism; D009942:Organometallic Compounds / Q000097:blood / Q000378:metabolism*; D004369:Pentetic Acid / Q000097:blood / Q000378:metabolism*; D011817:Rabbits; D013667:Technetium / Q000097:blood / Q000378:metabolism*; D016284:Technetium Tc 99m Pentetate | D003160:Comparative Study; D016428:Journal Article | D009942:Organometallic Compounds; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate | [] | false | eng | J Nucl Med | 0217410 | 0161-5505 | United States | [] | "2024-08-13T08:46:10.049961Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Iodine-123 HIPDM brain imaging findings in subacute spongiform encephalopathy (Creutzfeldt-Jakob disease). | 28(9) | 1484-7 | Decreased perfusion of the left frontal and left temporoparietal cortex has been shown in [123I] HIPDM planar and single photon emission computed tomographic images of a patient with Creutzfeldt-Jakob disease (CJD) that was proven by brain biopsy and subsequent autopsy. An EEG showed diffuse, periodic discharges most prominent to the left hemisphere. Concurrent head computed tomography (CT), nuclear magnetic resonance (NMR), and cerebral angiographic studies were negative. Abnormalities demonstrated by [123I]HPDM imaging and by EEG may represent changes in neurophysiological and neurochemical status while cerebral angiography, CT, and possibly NMR register only anatomic or structural lesions. Premortem diagnosis of CJD depends on brain biopsy; the availability of the [123I] HIPDM study may provide regional cerebral neurochemical and neurophysiological information, guiding or avoiding brain biopsy in the appropriate clinical setting. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine | [
{
"affiliation": "",
"forename": "W J",
"identifier": "",
"initials": "WJ",
"lastname": "Shih"
},
{
"affiliation": "",
"forename": "W R",
"identifier": "",
"initials": "WR",
"lastname": "Markesbery"
},
{
"affiliation": "",
"forename": "D B",
"identifier": "",
"initials": "DB",
"lastname": "Clark"
},
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Goldstein"
},
{
"affiliation": "",
"forename": "P A",
"identifier": "",
"initials": "PA",
"lastname": "Domstad"
},
{
"affiliation": "",
"forename": "J J",
"identifier": "",
"initials": "JJ",
"lastname": "Coupal"
},
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Kung"
},
{
"affiliation": "",
"forename": "S T",
"identifier": "",
"initials": "ST",
"lastname": "DeKosky"
},
{
"affiliation": "",
"forename": "F H",
"identifier": "",
"initials": "FH",
"lastname": "DeLand"
}
] | 1987-09 | 3305807 | D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D007562:Creutzfeldt-Jakob Syndrome / Q000000981:diagnostic imaging*; D006801:Humans; D007462:Iodobenzenes; D008297:Male; D011877:Radionuclide Imaging | D002363:Case Reports; D016428:Journal Article; D013487:Research Support, U.S. Gov't, P.H.S. | D007462:Iodobenzenes; C036739:N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine | [] | false | eng | J Nucl Med | 0217410 | 0161-5505 | United States | [
{
"agency": "NCRR NIH HHS",
"country": "United States",
"grant_acronym": "RR",
"grant_id": "RR 05374"
}
] | "2024-08-13T08:46:10.052111Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Right occipital cerebral abscess caused by Aspergillus fumigatus. | 31(1) | 29-31 | A rare case of intracerebral abscess caused by aspergillus fumigatus located in the right occipital region is described; pathogenesis, prognosis and treatment of this particular infection are discussed. | Journal of neurosurgical sciences | [
{
"affiliation": "",
"forename": "D",
"identifier": "",
"initials": "D",
"lastname": "Lucantoni"
},
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Galzio"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Zenobii"
},
{
"affiliation": "",
"forename": "V",
"identifier": "",
"initials": "V",
"lastname": "Magliani"
},
{
"affiliation": "",
"forename": "G",
"identifier": "",
"initials": "G",
"lastname": "Sciarra"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "D'Arrigo"
}
] | 1987 | 3305803 | D000368:Aged; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D001232:Aspergillus fumigatus; D001922:Brain Abscess / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D011859:Radiography | D002363:Case Reports; D016428:Journal Article | [] | false | eng | J Neurosurg Sci | 0432557 | 0390-5616 | Italy | [] | "2024-08-13T08:46:10.052920Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
In vivo inorganic chemistry of technetium cations. | 28(9) | 1491-500 | Technetium-99m cations are of interest because of their potential use as myocardial perfusion imaging agents. These species can undergo in vivo reactions which markedly affect their biodistribution patterns. Four such cases of reactions are presented and discussed: (1) simple ligand substitution; (2) metal centered redox processes; (3) reactions of coordinated ligands; (4) outer sphere association reactions. New experimental techniques appropriate for investigating these reactions at the 10(-10) M concentration level of technetium encountered in vivo are also presented and discussed. The latter three classes of reactions are illustrated by examples taken from the recent literature and from unpublished data. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine | [
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Deutsch"
},
{
"affiliation": "",
"forename": "W",
"identifier": "",
"initials": "W",
"lastname": "Hirth"
}
] | 1987-09 | 3305808 | D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D009942:Organometallic Compounds / Q000378:metabolism; D015609:Organotechnetium Compounds; D010084:Oxidation-Reduction; D010720:Phosphines / Q000378:metabolism; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't; D013487:Research Support, U.S. Gov't, P.H.S.; D016454:Review | D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D010720:Phosphines; D013667:Technetium; C031898:technetium Tc 99m bis(1,2-dimethylphosphino)ethane | [] | false | eng | J Nucl Med | 0217410 | 0161-5505 | United States | [
{
"agency": "NCI NIH HHS",
"country": "United States",
"grant_acronym": "CA",
"grant_id": "CA-42179"
},
{
"agency": "NHLBI NIH HHS",
"country": "United States",
"grant_acronym": "HL",
"grant_id": "HL-21276"
}
] | "2024-08-13T08:46:10.053747Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Renal scintigraphy in the evaluation of renovascular hypertension: a note of optimism yet caution. | 28(9) | 1501-5 | Journal of nuclear medicine : official publication, Society of Nuclear Medicine | [
{
"affiliation": "",
"forename": "J V",
"identifier": "",
"initials": "JV",
"lastname": "Nally"
}
] | 1987-09 | 3305809 | D006801:Humans; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging*; D011866:Radioisotope Renography / Q000379:methods* | D016428:Journal Article; D016454:Review | [] | false | eng | J Nucl Med | 0217410 | 0161-5505 | United States | [] | "2024-08-13T08:46:10.054623Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
Computerizing orientation. | 3(3) | 140 | Journal of nursing staff development : JNSD | [
{
"affiliation": "",
"forename": "D",
"identifier": "",
"initials": "D",
"lastname": "Miller"
}
] | 1987 | 3305810 | D003194:Computer-Assisted Instruction; D004509:Education, Nursing, Continuing; D006801:Humans; D007318:Inservice Training; D009741:Nursing Staff, Hospital / Q000193:education* | D016428:Journal Article | [] | false | eng | J Nurs Staff Dev | 8601288 | 0882-0627 | United States | [] | "2024-08-13T08:46:10.055118Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
Dietary mackerel oil in pigs: effect on plasma lipids, cardiac sarcolemmal phospholipids and cardiovascular parameters. | 117(8) | 1371-8 | The influence of substitution of eicosapentanoic acid to the diet has been investigated in juvenile domestic pigs (7-8 kg) fed either a mixture of 4.5% (wt/wt) mackerel oil and 4.5% (wt/wt) lard fat (n = 12, ML group) or a 9% (wt/wt) lard fat (n = 12, L group) diet for 16 wk. Plasma triglyceride and total cholesterol did not change in L, but had decreased in ML to 51 +/- 8 and 81 +/- 8% of the initial values, respectively, at the end of this period; the largest decreases already occurred during the first 8 wk. HDL cholesterol of both L and ML were not affected. After 16 wk, postprandial responses of plasma triglyceride, total cholesterol and glucose and insulin, determined at hourly intervals during the first 8 h postfeeding, did not show any differences for the two dietary groups. In spite of a marked replacement of n-6 fatty acids by n-3 fatty acids in cardiac sarcolemmal membranes in ML, there were no major differences in cardiovascular performance (myocardial contractility, pre- and afterload, cardiac output and myocardial work) between L and ML, when measured under baseline conditions and after the heart was stressed by atrial pacing (heart rate: 160 beats/min). In conclusion, feeding moderate amounts of mackerel oil [0.3 g 20:5 n-3/(kg body weight.d)] to pigs during 16 wk produces decreases of the plasma levels of total cholesterol and triglyceride, but does not affect plasma HDL cholesterol and routine cardiovascular parameters. | The Journal of nutrition | [
{
"affiliation": "",
"forename": "J M",
"identifier": "",
"initials": "JM",
"lastname": "Hartog"
},
{
"affiliation": "",
"forename": "P D",
"identifier": "",
"initials": "PD",
"lastname": "Verdouw"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Klompe"
},
{
"affiliation": "",
"forename": "J M",
"identifier": "",
"initials": "JM",
"lastname": "Lamers"
}
] | 1987-08 | 3305815 | D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D012508:Sarcolemma / Q000378:metabolism*; D013552:Swine; D014280:Triglycerides / Q000097:blood | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D001786:Blood Glucose; D004041:Dietary Fats; D005227:Fatty Acids; D005395:Fish Oils; D007328:Insulin; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol | 10.1093/jn/117.8.1371 | [] | false | eng | J Nutr | 0404243 | 0022-3166 | United States | [] | "2024-08-13T08:46:10.056207Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Intestinal calcium absorption: mechanisms and applications. | 117(8) | 1347-52 | Calcium absorption from the intestine involves two sets of events. One, a saturable transcellular process is regulated by vitamin D via its molecular product, the calcium-binding protein (CaBP, MW = 8800). This transcellular movement is largely confined to the proximal portion of the intestine. The second process is nonsaturable, occurs throughout the length of the intestine and is paracellular. Evidence in support of these statements is discussed, with emphasis on kinetic considerations. It is proposed that CaBP acts as a ferry, amplifying the intracellular movement of calcium by a factor of about 60, thereby enabling transcellular calcium transport to reach the measured values of Vm = 22 mumol/h per gram (wet) duodenum, with Km = 3.9 mM. The transcellular process is subject to down-regulation and is influenced by functional or nutritional factors such as age or calcium intake. The nonsaturable process, on the other hand, is not directly influenced by these or related events. Vitamin D therapy alters active calcium transport, but may lead to undesirable effects at other target organs, e.g., kidney or bone. An increase in calcium intake is the simplest method for increasing the amount absorbed. Future research may show whether paracellular pathway alterations are a practical approach to changing the amount of calcium absorbed by the nonsaturable process. | The Journal of nutrition | [
{
"affiliation": "",
"forename": "F",
"identifier": "",
"initials": "F",
"lastname": "Bronner"
}
] | 1987-08 | 3305814 | D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D007408:Intestinal Absorption; D007700:Kinetics; D064030:S100 Calcium Binding Protein G / Q000502:physiology; D014807:Vitamin D / Q000502:physiology | D016428:Journal Article; D016454:Review | D064030:S100 Calcium Binding Protein G; D014807:Vitamin D; D002118:Calcium | 10.1093/jn/117.8.1347 | [] | false | eng | J Nutr | 0404243 | 0022-3166 | United States | [] | "2024-08-13T08:46:10.058152Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Amino acid requirements in the adult human: how well do we know them? | 117(8) | 1484-7 | The Journal of nutrition | [
{
"affiliation": "",
"forename": "V R",
"identifier": "",
"initials": "VR",
"lastname": "Young"
},
{
"affiliation": "",
"forename": "D M",
"identifier": "",
"initials": "DM",
"lastname": "Bier"
}
] | 1987-08 | 3305816 | D000328:Adult; D000596:Amino Acids / Q000008:administration & dosage / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007700:Kinetics; D009751:Nutritional Requirements | D016428:Journal Article; D016454:Review | D000596:Amino Acids | 10.1093/jn/117.8.1484 | [] | false | eng | J Nutr | 0404243 | 0022-3166 | United States | [] | "2024-08-13T08:46:10.058942Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Dating pregnancy. Gathering and using a reliable data base. | 32(4) | 195-204 | Journal of nurse-midwifery | [
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Nichols"
}
] | 1987 | 3305812 | D005260:Female; D005865:Gestational Age; D006801:Humans; D008598:Menstruation; D011247:Pregnancy; D011295:Prenatal Care / Q000379:methods*; D014463:Ultrasonography; D014599:Uterus / Q000033:anatomy & histology | D016428:Journal Article | 10.1016/0091-2182(87)90110-8 | [] | false | eng | J Nurse Midwifery | 0365647 | 0091-2182 | United States | [] | "2024-08-13T08:46:10.059488Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
JONA's Semiannual Directory of Consultants to Nursing Administration. | 17(7-8) | 39-84 | The Journal of nursing administration | [] | 1987 | 3305811 | D000288:Administrative Personnel; D002170:Canada; D003253:Consultants; D004181:Directories as Topic; D009718:Nurse Administrators; D014481:United States | D016435:Directory | 10.1097/00005110-198707000-00009 | [] | false | eng | J Nurs Adm | 1263116 | 0002-0443 | United States | [] | "2024-08-13T08:46:10.059977Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Social coercion for weaning. | 32(4) | 205-10 | Journal of nurse-midwifery | [
{
"affiliation": "",
"forename": "J M",
"identifier": "",
"initials": "JM",
"lastname": "Morse"
},
{
"affiliation": "",
"forename": "M J",
"identifier": "",
"initials": "MJ",
"lastname": "Harrison"
}
] | 1987 | 3305813 | D000367:Age Factors; D001290:Attitude; D005260:Female; D006801:Humans; D007223:Infant; D009035:Mothers / Q000523:psychology; D012931:Social Environment; D014886:Weaning | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't; D016454:Review | 10.1016/0091-2182(87)90111-x | [] | false | eng | J Nurse Midwifery | 0365647 | 0091-2182 | United States | [] | "2024-08-13T08:46:10.060788Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Morphology of cyclosporine nephrotoxicity in human heart transplant recipients. | 5(4) | 273-8 | The morphologic findings of renal biopsies (four cases studied by electron microscopy) and renal specimens obtained from 44 autopsies of patients who died after heart transplantation are reviewed. Eight patients treated postoperatively with cyclosporine (serum concentration of 100 to 150 ng/ml), with a survival rate of 1 to 24 months, constantly had renal lesions of variable severity. Correlated with functional renal disturbances, these changes predominantly affect the proximal convoluted tubule: vacuolization, calcifications, and tubular atrophy. The interstitial fibrosis, increasing parallel to tubular alterations, occurs only after 3 months after transplantation. The hypertrophy of juxtaglomerular apparatus and the arteriolar sclerosis noted on and after the fourth month were associated with arterial hypertension. Among the other inconstant and mild lesions (attrition of vascular endothelium and arteriolar or glomerular thrombi), the partial sclerosis of glomerular flocculus, probably correlated with tubular lesions, seems more significant. Thus these findings corroborate the nephrotoxicity of cyclosporine (principally against the proximal convoluted tube), the increase of lesions with time, and the possible irreversibility of the lesions despite appropriately decreasing the dosage of cyclosporine to eliminate toxic side effects. | The Journal of heart transplantation | [
{
"affiliation": "",
"forename": "G",
"identifier": "",
"initials": "G",
"lastname": "Chomette"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Auriol"
},
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Beaufils"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Rottemburg"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Cabrol"
}
] | 1986 | 3305818 | D058186:Acute Kidney Injury / Q000139:chemically induced; D000293:Adolescent; D000328:Adult; D003524:Cyclosporins / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006085:Graft Survival / Q000187:drug effects; D016027:Heart Transplantation; D006801:Humans; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male | D016428:Journal Article | D003524:Cyclosporins | [] | false | eng | J Heart Transplant | 8604172 | 0887-2570 | United States | [] | "2024-08-13T08:46:10.061618Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Heart allograft rejection under varying immunosuppressive protocols as evaluated by endomyocardial biopsy. | 5(4) | 279-85 | Rejection episodes in 259 heart allograft recipients and 29 heart-lung transplant patients at Stanford University were examined from the viewpoint of endomyocardial biopsy. The patients were divided into the following six groups by immunosuppressive regimen: Group 1 (100 patients) was treated with conventional immunosuppression. Group 2 (26 patients) was treated with cyclosporine in combination with low-dose corticosteroids and an initial 3- to 4-day course of rabbit antithymocyte globulin. Group 3 (76 patients) was treated with cyclosporine and low-dose corticosteroids. Group 4 (34 patients) was treated with low-dose cyclosporine, azathioprine, and low-dose corticosteroids. Group 5 (23 patients) was treated with low-dose cyclosporine and azathioprine, but initially without low-dose corticosteroids. Group 6 was composed of 29 heart-lung transplant recipients. Groups 1, 2, and 6 had significantly less rejection episodes than group 3, and groups 4 and 5 had more rejection episodes than group 3. In patients with a diagnosis of mild acute rejection on cyclosporine, a repeat biopsy shows progression to a moderate acute rejection in 21% to 43% of cases, emphasizing the importance of this diagnosis even in cyclosporine-treated patients. The characteristics of acute heart allograft rejection as assessed by endomyocardial biopsy are important to recognize. In part as a result of the data presented here, further modifications in the immunosuppressive regimen of the Stanford heart and heart-lung transplant recipients are being undertaken. | The Journal of heart transplantation | [
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Imakita"
},
{
"affiliation": "",
"forename": "H D",
"identifier": "",
"initials": "HD",
"lastname": "Tazelaar"
},
{
"affiliation": "",
"forename": "M E",
"identifier": "",
"initials": "ME",
"lastname": "Billingham"
}
] | 1986 | 3305819 | D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003524:Cyclosporins / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004699:Endocardium / Q000473:pathology*; D006084:Graft Rejection / Q000187:drug effects*; D006321:Heart / Q000187:drug effects; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects; D016040:Lung Transplantation; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't; D013487:Research Support, U.S. Gov't, P.H.S. | D003524:Cyclosporins; D007166:Immunosuppressive Agents; D001379:Azathioprine; D011241:Prednisone | [] | false | eng | J Heart Transplant | 8604172 | 0887-2570 | United States | [
{
"agency": "NHLBI NIH HHS",
"country": "United States",
"grant_acronym": "HL",
"grant_id": "1 F32 HL 07189-01"
},
{
"agency": "NHLBI NIH HHS",
"country": "United States",
"grant_acronym": "HL",
"grant_id": "HL 13108"
}
] | "2024-08-13T08:46:10.064362Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Successful six-hour cardiopulmonary preservation with simple hypothermic crystalloid flush. | 5(4) | 291-7 | Combined heart and lung transplantation was performed in 12 cynomolgus or rhesus monkeys. The donor heart was preserved with 10 ml/kg of cold crystalloid potassium cardioplegia. The lungs were preserved by perfusing the pulmonary artery over 4 minutes with 60 ml/kg donor weight of cold Euro-Collins solution modified with 8 mEq/L of MgSO4. For six animals in group A, the heart and lungs were immediately transplanted with a mean ischemic time of 1 hour 54 minutes. For six animals in group B, the heart and lungs were stored in a cold extracellular electrolyte solution at 2 degrees to 3 degrees C and transplantation was delayed, with a mean ischemic time of 6 hours and 15 minutes. Anesthesia and mechanical volume ventilation were continued for 8 hours postoperatively with the Fio2 regulated to 40% and with 2 cm positive end-expiratory pressure. Arterial Po2 was sampled at 1, 2, 3, 4, 6, and 8 hours after removal of the aortic cross clamp. Animal survival and cause of death were recorded. All animals were successfully extubated by 10 hours after transplantation. The mean arterial Po2 for group B was initially depressed (89 mm Hg 1 hour after removal of the aortic cross clamp) but rapidly recovered. The mean Po2 for both groups A and B was 184 mm Hg 8 hours after reperfusion. There was no significant difference in the mean hourly Po2 between groups A and B except for the first hour after reperfusion. One animal in each group died of pulmonary insufficiency in the early postoperative period.(ABSTRACT TRUNCATED AT 250 WORDS) | The Journal of heart transplantation | [
{
"affiliation": "",
"forename": "T D",
"identifier": "",
"initials": "TD",
"lastname": "Starkey"
},
{
"affiliation": "",
"forename": "N",
"identifier": "",
"initials": "N",
"lastname": "Sakakibara"
},
{
"affiliation": "",
"forename": "R C",
"identifier": "",
"initials": "RC",
"lastname": "Hagberg"
},
{
"affiliation": "",
"forename": "H D",
"identifier": "",
"initials": "HD",
"lastname": "Tazelaar"
},
{
"affiliation": "",
"forename": "J C",
"identifier": "",
"initials": "JC",
"lastname": "Baldwin"
},
{
"affiliation": "",
"forename": "S W",
"identifier": "",
"initials": "SW",
"lastname": "Jamieson"
}
] | 1986 | 3305820 | D000818:Animals; D003080:Cold Temperature; D004573:Electrolytes; D006084:Graft Rejection; D016027:Heart Transplantation; D006982:Hypertonic Solutions; D008168:Lung / Q000473:pathology; D016040:Lung Transplantation; D008252:Macaca fascicularis; D008253:Macaca mulatta; D009206:Myocardium / Q000473:pathology; D009926:Organ Preservation / Q000379:methods*; D010100:Oxygen / Q000097:blood; D011188:Potassium; D017680:Potassium Compounds; D012129:Respiratory Function Tests; D013997:Time Factors | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't; D013487:Research Support, U.S. Gov't, P.H.S. | D004573:Electrolytes; C037096:Euro-Collins' solution; D006982:Hypertonic Solutions; D017680:Potassium Compounds; C018369:potassium cardioplegic solution; D011188:Potassium; D010100:Oxygen | [] | false | eng | J Heart Transplant | 8604172 | 0887-2570 | United States | [
{
"agency": "NHLBI NIH HHS",
"country": "United States",
"grant_acronym": "HL",
"grant_id": "HL08696-22"
}
] | "2024-08-13T08:46:10.065453Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Effects of steroids in combination with other pharmacologic immunosuppressive agents. | 5(4) | 304-6 | Steroids are commonly employed as immunosuppressive agents following organ transplantation. They may be given in large doses at the time of transplantation and also at times of rejection. At lower doses they are commonly used as maintenance therapy. The justification for these forms of treatments has been critically examined, and the author refers to his own experimental studies and clinical trials of steroids following kidney transplantation. The conclusion reached is that steroids are usually effective in reversing rejection, but there is no good evidence that they are required at the moment of transplantation or for long-term administration afterward if patients are already receiving cyclosporine. | The Journal of heart transplantation | [
{
"affiliation": "",
"forename": "J R",
"identifier": "",
"initials": "JR",
"lastname": "Salaman"
}
] | 1986 | 3305822 | D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003524:Cyclosporins / Q000008:administration & dosage / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000187:drug effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects; D016030:Kidney Transplantation; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage* / Q000627:therapeutic use | D003160:Comparative Study; D016428:Journal Article | D003524:Cyclosporins; D007166:Immunosuppressive Agents; D011239:Prednisolone; D008775:Methylprednisolone | [] | false | eng | J Heart Transplant | 8604172 | 0887-2570 | United States | [] | "2024-08-13T08:46:10.066543Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Differences in the pathogenesis of first-set allograft rejection and acute xenograft rejection as determined by sequential morphologic analysis. | 5(4) | 263-6 | To examine the pathogenesis of unmodified heart xenograft and allograft rejection, a sequential morphologic analysis was undertaken. Heterotopic cardiac allografts and xenografts were performed by implanting donor hearts into the abdomen of Lewis rats. Xenograft donors were Golden Syrian hamsters and allograft donors were ACI rats. Both xenografts and allografts were excised and examined by light microscopy at specific postoperative intervals. Allograft rejection was found to be a cell-mediated process, beginning with interstitial infiltrates and perivascular cuffing, which progressed to focal myocyte necroses. Ultimately, complete replacement of the myocardium by mononuclear cells was noted in fully rejected hearts. Xenograft rejection was markedly different. Although xenograft rejection was characterized first by interstitial mononuclear cell infiltrates, unlike allografts there was only minimal progression of cellular rejection. Instead, subsequent rejection was characterized by marked interstitial edema and arteriolar vasculitis and thrombosis, leading to extensive infarcts and hemorrhage in fully rejected hearts. Fibrinoid arteriolar changes and the rapid development of edema in the absence of significant cellular infiltrate suggest that cytotoxic antibodies alter xenograft vascular permeability. These data suggest that humoral immunity is largely responsible for acute concordant xenograft rejection, whereas first-set allograft rejection is mainly a cell-mediated process. | The Journal of heart transplantation | [
{
"affiliation": "",
"forename": "B R",
"identifier": "",
"initials": "BR",
"lastname": "Rosengard"
},
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Adachi"
},
{
"affiliation": "",
"forename": "K",
"identifier": "",
"initials": "K",
"lastname": "Ueda"
},
{
"affiliation": "",
"forename": "T S",
"identifier": "",
"initials": "TS",
"lastname": "Hall"
},
{
"affiliation": "",
"forename": "G M",
"identifier": "",
"initials": "GM",
"lastname": "Hutchins"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Herskowitz"
},
{
"affiliation": "",
"forename": "A M",
"identifier": "",
"initials": "AM",
"lastname": "Borkon"
},
{
"affiliation": "",
"forename": "W A",
"identifier": "",
"initials": "WA",
"lastname": "Baumgartner"
},
{
"affiliation": "",
"forename": "B A",
"identifier": "",
"initials": "BA",
"lastname": "Reitz"
}
] | 1986 | 3305817 | D000818:Animals; D006224:Cricetinae; D006084:Graft Rejection; D016027:Heart Transplantation; D008297:Male; D008647:Mesocricetus; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D011912:Rats, Inbred ACI; D011917:Rats, Inbred Lew; D013997:Time Factors; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous | D003160:Comparative Study; D016428:Journal Article | [] | false | eng | J Heart Transplant | 8604172 | 0887-2570 | United States | [] | "2024-08-13T08:46:10.067586Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Acute right ventricular failure following heart transplantation: improvement with prostaglandin E1 and right ventricular assist. | 5(4) | 317-21 | Development of significant pulmonary hypertension following orthotopic heart transplantation can result in death caused by irreversible right ventricular failure. Despite determination of acceptable preoperative pulmonary vascular resistance, this complication may still occur. This report illustrates the technique of right ventricular assist and concomitant infusion of intrapulmonary prostaglandin E1 for the treatment of postoperative right ventricular failure resulting from pulmonary hypertension. | The Journal of heart transplantation | [
{
"affiliation": "",
"forename": "J D",
"identifier": "",
"initials": "JD",
"lastname": "Fonger"
},
{
"affiliation": "",
"forename": "A M",
"identifier": "",
"initials": "AM",
"lastname": "Borkon"
},
{
"affiliation": "",
"forename": "W A",
"identifier": "",
"initials": "WA",
"lastname": "Baumgartner"
},
{
"affiliation": "",
"forename": "S C",
"identifier": "",
"initials": "SC",
"lastname": "Achuff"
},
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Augustine"
},
{
"affiliation": "",
"forename": "B A",
"identifier": "",
"initials": "BA",
"lastname": "Reitz"
}
] | 1986 | 3305824 | D000208:Acute Disease; D000328:Adult; D000527:Alprostadil / Q000627:therapeutic use*; D001243:Assisted Circulation / Q000009:adverse effects; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D016027:Heart Transplantation; D006353:Heart-Assist Devices / Q000009:adverse effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D008297:Male; D014184:Transplantation, Homologous / Q000009:adverse effects | D002363:Case Reports; D016428:Journal Article | D000527:Alprostadil | [] | false | eng | J Heart Transplant | 8604172 | 0887-2570 | United States | [] | "2024-08-13T08:46:10.068592Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Self-reported change in physical symptoms from cyclosporine-based therapy to azathioprine-based therapy in heart transplant recipients. | 5(4) | 322-6 | Since the introduction of cyclosporine, 183 heart transplants have been performed at Stanford University Medical Center. Although cyclosporine has improved survival rates, it is also associated with progressive renal dysfunction. Seventeen of these recipients have been converted from cyclosporine-based therapy to azathioprine-based therapy because of significant nephrotoxicity. Fourteen of these recipients participated in a study to examine change in physical symptoms since immunoconversion. Most reported little change in physical symptoms following conversion, although 79% experienced rejection following the drug change. Overall, the change in immunosuppressive medications had little impact on perceived symptoms. | The Journal of heart transplantation | [
{
"affiliation": "",
"forename": "M E",
"identifier": "",
"initials": "ME",
"lastname": "Lough"
},
{
"affiliation": "",
"forename": "J L",
"identifier": "",
"initials": "JL",
"lastname": "Miller"
},
{
"affiliation": "",
"forename": "P",
"identifier": "",
"initials": "P",
"lastname": "Gamberg"
}
] | 1986 | 3305825 | D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D003524:Cyclosporins / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006084:Graft Rejection; D016027:Heart Transplantation; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D014184:Transplantation, Homologous / Q000401:mortality | D016428:Journal Article | D003524:Cyclosporins; D001379:Azathioprine | [] | false | eng | J Heart Transplant | 8604172 | 0887-2570 | United States | [] | "2024-08-13T08:46:10.070508Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Transposition of the greater omentum for management of mediastinal infection following orthotopic heart transplantation: a case report. | 5(4) | 330-1 | A case of mediastinal infection following orthotopic heart transplantation is presented. A general survey of the available surgical management of this complication is given and an alternative operation involving extra-abdominal transposition of the greater omentum pedicled on the left gastroepiploic vessels is suggested for treating difficult cases. | The Journal of heart transplantation | [
{
"affiliation": "",
"forename": "K",
"identifier": "",
"initials": "K",
"lastname": "Frimpong-Boateng"
},
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Warnecke"
},
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Schüler"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Haverich"
},
{
"affiliation": "",
"forename": "H G",
"identifier": "",
"initials": "HG",
"lastname": "Borst"
}
] | 1986 | 3305827 | D004756:Enterobacteriaceae Infections / Q000209:etiology / Q000628:therapy*; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D008480:Mediastinitis / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D008482:Mediastinum / Q000000981:diagnostic imaging / Q000601:surgery; D008875:Middle Aged; D009852:Omentum / Q000601:surgery*; D012706:Serratia marcescens; D013530:Surgical Wound Infection / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous / Q000009:adverse effects* | D002363:Case Reports; D016428:Journal Article | [] | false | eng | J Heart Transplant | 8604172 | 0887-2570 | United States | [] | "2024-08-13T08:46:10.071360Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
The effect of heart transplantation on Cheyne-Stokes respiration associated with congestive heart failure. | 5(4) | 336-7 | Cheyne-Stokes respiration occasionally accompanies the terminal stages of congestive heart failure. We describe this association in a patient requiring heart transplantation. The gradual abatement of Cheyne-Stokes respiration after transplantation supports the delayed circulatory time theory as the mechanism for Cheyne-Stokes respiration in these patients. | The Journal of heart transplantation | [
{
"affiliation": "",
"forename": "D K",
"identifier": "",
"initials": "DK",
"lastname": "Murdock"
},
{
"affiliation": "",
"forename": "C E",
"identifier": "",
"initials": "CE",
"lastname": "Lawless"
},
{
"affiliation": "",
"forename": "H S",
"identifier": "",
"initials": "HS",
"lastname": "Loeb"
},
{
"affiliation": "",
"forename": "P J",
"identifier": "",
"initials": "PJ",
"lastname": "Scanlon"
},
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Pifarré"
}
] | 1986 | 3305828 | D002639:Cheyne-Stokes Respiration / Q000209:etiology / Q000503:physiopathology*; D006333:Heart Failure / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D016027:Heart Transplantation; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011669:Pulmonary Wedge Pressure; D012120:Respiration Disorders / Q000503:physiopathology* | D002363:Case Reports; D016428:Journal Article | [] | false | eng | J Heart Transplant | 8604172 | 0887-2570 | United States | [] | "2024-08-13T08:46:10.072364Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Bridging circulatory support before heart transplant without invasion of the mediastinum. | 6(2) | 116-9 | Heart transplantation is becoming a useful tool in the clinical treatment of patients with end-stage cardiac decompensation. Donor organs are not always available at a critical time for a patient waiting for a transplant. Bridging techniques have been described that use mechanical support systems. This article describes the use of femoral-venous to femoral-arterial bypass over a period of 50 hours in a 38-year-old woman waiting for a donor heart. Because the patient sustained cardiopulmonary arrest before organ availability, mechanical circulatory support that used femoral-venous to femoral-arterial bypass was instituted. The patient's own lungs were used as an oxygenator. Pump flow levels were determined by the level of central aortic oxygen saturation. Successful transplant was performed, and bridging, therefore, was done without invasion of the mediastinum. | The Journal of heart transplantation | [
{
"affiliation": "",
"forename": "S J",
"identifier": "",
"initials": "SJ",
"lastname": "Phillips"
},
{
"affiliation": "",
"forename": "R H",
"identifier": "",
"initials": "RH",
"lastname": "Zeff"
},
{
"affiliation": "",
"forename": "W J",
"identifier": "",
"initials": "WJ",
"lastname": "Wickemeyer"
},
{
"affiliation": "",
"forename": "C A",
"identifier": "",
"initials": "CA",
"lastname": "Shadur"
},
{
"affiliation": "",
"forename": "R S",
"identifier": "",
"initials": "RS",
"lastname": "Toon"
},
{
"affiliation": "",
"forename": "J R",
"identifier": "",
"initials": "JR",
"lastname": "Skinner"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Kongtahworn"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Grignon"
},
{
"affiliation": "",
"forename": "R M",
"identifier": "",
"initials": "RM",
"lastname": "Kennerly"
},
{
"affiliation": "",
"forename": "K W",
"identifier": "",
"initials": "KW",
"lastname": "Min"
}
] | 1987 | 3305829 | D000328:Adult; D001243:Assisted Circulation; D005260:Female; D006323:Heart Arrest / Q000503:physiopathology / Q000628:therapy; D016027:Heart Transplantation; D006801:Humans; D011300:Preoperative Care | D002363:Case Reports; D016428:Journal Article | [] | false | eng | J Heart Transplant | 8604172 | 0887-2570 | United States | [] | "2024-08-13T08:46:10.073356Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
The stability of Le Fort I maxillary osteotomies in patients with simultaneous alveolar cleft bone grafts. | 45(9) | 761-6 | A retrospective study was performed on 20 patients who had been treated with Le Fort I maxillary osteotomies and simultaneous alveolar cleft bone grafts. The age range was 11 to 23 years, and there were 11 males and nine females. Changes in both anterior-posterior (A-P) and vertical direction were investigated using preoperative, immediate postoperative, and long-term postoperative lateral cephalometric radiographs. The results indicated little change between the immediate postoperative and long-term postoperative position of the maxilla in an A-P dimension, but in a vertical direction there was a great tendency for relapse. | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | [
{
"affiliation": "",
"forename": "B T",
"identifier": "",
"initials": "BT",
"lastname": "Garrison"
},
{
"affiliation": "",
"forename": "T H",
"identifier": "",
"initials": "TH",
"lastname": "Lapp"
},
{
"affiliation": "",
"forename": "D A",
"identifier": "",
"initials": "DA",
"lastname": "Bussard"
}
] | 1987-09 | 3305836 | D000293:Adolescent; D000328:Adult; D000543:Alveoloplasty / Q000379:methods*; D016025:Bone Transplantation; D002648:Child; D002972:Cleft Palate / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008437:Maxilla / Q000033:anatomy & histology / Q000601:surgery*; D010027:Osteotomy / Q000379:methods*; D012008:Recurrence; D012189:Retrospective Studies; D014716:Vertical Dimension | D016428:Journal Article | 10.1016/0278-2391(87)90196-0 | [] | false | eng | J Oral Maxillofac Surg | 8206428 | 0278-2391 | United States | [] | "2024-08-13T08:46:10.074359Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Role of the carrier solution in cyclosporine pharmacokinetics in the baboon. | 5(4) | 312-6 | Although numerous investigational models have demonstrated the potent immunosuppressive properties of cyclosporine, the effectiveness of any given dosage may vary with the metabolism of the animal, the route of administration, and the carrier solution of the drug. We investigated the pharmacokinetics of intramuscular cyclosporine administration in the baboon using three carriers: polyoxethylated castor oil (Cremophor), a mixture of octanoic and decanoic acids (Miglyol), and olive oil. Cyclosporine prepared in Cremophor, Miglyol, or olive oil was injected intramuscularly into the hindlegs of baboons. Specimens for cyclosporine assay were obtained 2, 4, 6, 12, 18, and 24 hours after single intramuscular injection of 10 mg/kg or 15 mg/kg. In addition, weekly, then monthly, levels were obtained on animals receiving daily intramuscular injections following heterotopic heart xenografts. Attempts at oral administration proved unreliable and were discontinued. Cyclosporine assay was performed on stored serum using the RIA-KIT (Sandoz Pharmaceuticals Corporation, East Hanover, N.J.). Cremophor provides a more bioavailable form of cyclosporine than Miglyol when administered intramuscularly. (Area under curve = 7776 +/- 1437 for Cremophor 15 mg/kg vs 1837 +/- 726 for Miglyol 15 mg/kg; 2579 +/- 694 for Cremophor 10 vs 1123 +/- 393 for Miglyol 10.) Long-term daily intramuscular administration of Cremophor provides a sustained drug serum trough level with wide variability between individual animals (80 to 825 ng/ml). Toxicity was limited to injection site inflammation. There was no biochemical evidence of renal toxicity; however, some animals did demonstrate early histologic changes of cyclosporine effect.(ABSTRACT TRUNCATED AT 250 WORDS) | The Journal of heart transplantation | [
{
"affiliation": "",
"forename": "P A",
"identifier": "",
"initials": "PA",
"lastname": "Kurlansky"
},
{
"affiliation": "",
"forename": "A M",
"identifier": "",
"initials": "AM",
"lastname": "Sadeghi"
},
{
"affiliation": "",
"forename": "R E",
"identifier": "",
"initials": "RE",
"lastname": "Michler"
},
{
"affiliation": "",
"forename": "L J",
"identifier": "",
"initials": "LJ",
"lastname": "Coppey"
},
{
"affiliation": "",
"forename": "L P",
"identifier": "",
"initials": "LP",
"lastname": "Re"
},
{
"affiliation": "",
"forename": "W G",
"identifier": "",
"initials": "WG",
"lastname": "Thomas"
},
{
"affiliation": "",
"forename": "C R",
"identifier": "",
"initials": "CR",
"lastname": "Smith"
},
{
"affiliation": "",
"forename": "K",
"identifier": "",
"initials": "K",
"lastname": "Reemtsma"
},
{
"affiliation": "",
"forename": "E A",
"identifier": "",
"initials": "EA",
"lastname": "Rose"
}
] | 1986 | 3305823 | D000818:Animals; D001682:Biological Availability; D003524:Cyclosporins / Q000009:adverse effects / Q000378:metabolism* / Q000494:pharmacology; D004338:Drug Combinations; D006321:Heart / Q000187:drug effects; D016027:Heart Transplantation; D007273:Injections, Intramuscular; D007668:Kidney / Q000187:drug effects; D007700:Kinetics; D000069463:Olive Oil; D010215:Papio; D014677:Pharmaceutical Vehicles / Q000378:metabolism* / Q000494:pharmacology; D010938:Plant Oils / Q000008:administration & dosage / Q000378:metabolism; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism / Q000494:pharmacology | D016428:Journal Article | D003524:Cyclosporins; D004338:Drug Combinations; D000069463:Olive Oil; D014677:Pharmaceutical Vehicles; D010938:Plant Oils; D014280:Triglycerides; C022834:miglyol 812; C022131:cremophor; D011092:Polyethylene Glycols | [] | false | eng | J Heart Transplant | 8604172 | 0887-2570 | United States | [] | "2024-08-13T08:46:10.076592Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Arteriographic assessment of patency of the inferior alveolar artery and its relevance to alveolar atrophy. | 45(9) | 767-70 | Patency of the inferior alveolar artery was investigated on 84 patients who had undergone selective external carotid angiography with digital subtraction. Patency of the artery was lost earlier in males than females, but the presence or absence of teeth did not appear to affect the outcome. The artery was visualized less well on patients with medical conditions that may predispose to early or excessive atherosclerotic disease. | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | [
{
"affiliation": "",
"forename": "M A",
"identifier": "",
"initials": "MA",
"lastname": "Pogrel"
},
{
"affiliation": "",
"forename": "T",
"identifier": "",
"initials": "T",
"lastname": "Dodson"
},
{
"affiliation": "",
"forename": "W",
"identifier": "",
"initials": "W",
"lastname": "Tom"
}
] | 1987-09 | 3305837 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000792:Angiography; D001158:Arteries / Q000033:anatomy & histology; D001161:Arteriosclerosis / Q000000981:diagnostic imaging; D001284:Atrophy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007575:Jaw, Edentulous / Q000000981:diagnostic imaging; D008297:Male; D008334:Mandible / Q000098:blood supply* / Q000473:pathology; D008875:Middle Aged; D012306:Risk; D013382:Subtraction Technique | D016428:Journal Article | 10.1016/0278-2391(87)90198-4 | [] | false | eng | J Oral Maxillofac Surg | 8206428 | 0278-2391 | United States | [] | "2024-08-13T08:46:10.077611Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Feasibility of discontinuation of corticosteroid maintenance therapy in heart transplantation. | 6(2) | 71-8 | Corticosteroid maintenance immunosuppression therapy was successfully discontinued in 24 of 46 patients (52%) who underwent orthotopic heart transplantation between March 8, 1985 and September 1, 1986. In the remaining 22 patients three or more rejection episodes occurred within a 4-month period, and these patients were subsequently maintained on low to moderate dosages of corticosteroids. Patients successfully withdrawn from corticosteroid maintenance (group 1) have remained rejection free for 208 +/- 33 days (mean +/- SEM) after discontinuation of the maintenance therapy with corticosteroids, and their immunosuppression therapy has consisted only of cyclosporine (mean overall cumulative dose 198 +/- 11 mg/m2/day [5.17 +/- 0.35 mg/kg/day]) and azathioprine (mean overall cumulative dose 67.7 +/- 5.4 mg/m2/day [1.74 +/- 0.13 mg/kg/day]), with the most recent serum cyclosporine level and white blood cell count being 146 +/- 10 ng/ml and 5400 +/- 200/microliters, respectively. In contrast to the patients who continue to require maintenance therapy with corticosteroids (group 2), group 1 patients developed their first episode of rejection later (46.8 +/- 8.3 days versus 25.4 +/- 6.1 days, p = 0.040) and reject less frequently during the first 4 months after transplantation (1.7 +/- 0.2 episodes versus 2.6 +/- 0.2 episodes, p = 0.005) as well as during the entire follow-up period (0.21 +/- 0.02 episodes/month versus 0.30 +/- 0.02 episodes/month, p = 0.005). The decreased propensity to reject and subsequent corticosteroid discontinuation resulted in a decreased cumulative dose of corticosteroids in group 1 patients (10.9 +/- 1.9 mg prednisone equivalent/m2/day [0.28 +/- 0.04 mg/kg/day] versus 17.0 +/- 1.2 mg prednisone equivalent/m2/day [0.42 +/- 0.04 mg/kg/day], p = 0.011 [p = 0.026]).(ABSTRACT TRUNCATED AT 250 WORDS) | The Journal of heart transplantation | [
{
"affiliation": "",
"forename": "D G",
"identifier": "",
"initials": "DG",
"lastname": "Renlund"
},
{
"affiliation": "",
"forename": "J B",
"identifier": "",
"initials": "JB",
"lastname": "O'Connell"
},
{
"affiliation": "",
"forename": "E M",
"identifier": "",
"initials": "EM",
"lastname": "Gilbert"
},
{
"affiliation": "",
"forename": "F S",
"identifier": "",
"initials": "FS",
"lastname": "Watson"
},
{
"affiliation": "",
"forename": "M R",
"identifier": "",
"initials": "MR",
"lastname": "Bristow"
}
] | 1987 | 3305832 | D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D001379:Azathioprine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D003524:Cyclosporins / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D005240:Feasibility Studies; D005260:Female; D006084:Graft Rejection / Q000187:drug effects; D016027:Heart Transplantation; D006801:Humans; D008297:Male | D016428:Journal Article | D000305:Adrenal Cortex Hormones; D003524:Cyclosporins; D001379:Azathioprine | [] | false | eng | J Heart Transplant | 8604172 | 0887-2570 | United States | [] | "2024-08-13T08:46:10.078630Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
Subsets and Splits