title
stringlengths 2
512
| issue
stringlengths 0
29
| pages
stringlengths 1
35
| abstract
stringlengths 0
6.04k
| journal
stringlengths 2
239
| authors
listlengths 0
77
| pubdate
stringlengths 4
10
| pmid
stringlengths 1
7
| mesh_terms
stringlengths 0
2.39k
| publication_types
stringlengths 12
284
| chemical_list
stringlengths 0
920
| keywords
stringlengths 0
1.52k
| doi
stringlengths 0
69
| references
listlengths 0
1.3k
| delete
bool 1
class | languages
stringclasses 95
values | vernacular_title
stringlengths 0
491
| pmc
stringclasses 2
values | other_id
stringlengths 0
44
| medline_ta
stringlengths 2
96
| nlm_unique_id
stringlengths 7
9
| issn_linking
stringlengths 0
9
| country
stringclasses 90
values | grant_ids
listlengths 0
23
| _inserted_at
unknown | _read_from
stringclasses 109
values |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
[Special supportive measures in pediatric oncology]. | 199(3) | 127-30 | Klinische Padiatrie | [
{
"affiliation": "",
"forename": "D",
"identifier": "",
"initials": "D",
"lastname": "Niethammer"
}
] | 1987 | 3306127 | D016026:Bone Marrow Transplantation; D002648:Child; D005860:Germany, West; D006801:Humans; D008495:Medical Oncology / Q000639:trends*; D009369:Neoplasms / Q000628:therapy; D012106:Research | D016428:Journal Article | 10.1055/s-2008-1026778 | [] | false | ger | Spezielle Fördermassnahmen für die Pädiatrische Onkologie. | Klin Padiatr | 0326144 | 0300-8630 | Germany | [] | "2024-08-13T08:46:10.381211Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Cell-mediated autoimmunity at the onset of insulin-dependent diabetes mellitus (IDDM). | 65(12) | 546-50 | Peripheral blood lymphocytes have been investigated in 20 newly diagnosed type-I diabetics and 10 healthy subjects using monoclonal antibodies. Mononuclear cells were marked with anti-T-lymphocytes (Leu2, 3, 4, 12) and anti-Ia-antibodies (K14, L243) using indirect immunofluorescence. The percentage of circulating K14- and L243-positive cells was significantly higher in all diabetics than in normal controls. An increase in the number of K14-bearing cells was found in newly diagnosed patients with duration of less than 7 days (n = 10) compared with diabetics of longer duration (1 to 8 months; n = 10). Using dual-color immunofluorescence with fluorescein-conjugated anti-T-lymphocytes and rhodamin-conjugated anti-Ia-antibodies it was not possible to identify Ia-antigen bearing cells (Ia cells) as helper or suppressor lymphocytes. In addition, there was no significant difference in the number of Ia cells in diabetics with and without islet cell antibodies. It is concluded that there is evidence of activation of cellular immune response in type I diabetes, particularly in the early days of manifestation. However, previous assumptions that Ia cells represent T-cell activation have to be questioned. | Klinische Wochenschrift | [
{
"affiliation": "",
"forename": "A G",
"identifier": "",
"initials": "AG",
"lastname": "Ziegler"
},
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Standl"
},
{
"affiliation": "",
"forename": "T",
"identifier": "",
"initials": "T",
"lastname": "Lander"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Nerl"
},
{
"affiliation": "",
"forename": "E P",
"identifier": "",
"initials": "EP",
"lastname": "Rieber"
},
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Mehnert"
}
] | 1987-07-15 | 3306133 | D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D001323:Autoantibodies / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D013997:Time Factors | D003160:Comparative Study; D016428:Journal Article | D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D000949:Histocompatibility Antigens Class II | 10.1007/BF01727620 | [
{
"citation": "Science. 1976 Jul 30;193(4251):415-7",
"pmid": "180605"
},
{
"citation": "Diabetes. 1965 Oct;14(10):619-33",
"pmid": "5318831"
},
{
"citation": "Diabetologia. 1984 Jul;27 Suppl:136-8",
"pmid": "6237013"
},
{
"citation": "Scand J Clin Lab Invest Suppl. 1968;97:7",
"pmid": "5707208"
},
{
"citation": "Diabetologia. 1984 Jun;26(6):456-61",
"pmid": "6381192"
},
{
"citation": "Diabetologia. 1983 Apr;24(4):224-30",
"pmid": "6407886"
},
{
"citation": "Arthritis Rheum. 1981 Nov;24(11):1370-6",
"pmid": "6459096"
},
{
"citation": "Diabetes. 1985 Apr;34(4):373-9",
"pmid": "3882501"
},
{
"citation": "N Engl J Med. 1982 Apr 1;306(13):785-8",
"pmid": "7038489"
},
{
"citation": "Diabetologia. 1981 Aug;21(2):108-15",
"pmid": "6167481"
},
{
"citation": "Diabetologia. 1984 Jul;27 Suppl:132-5",
"pmid": "6332754"
},
{
"citation": "J Exp Med. 1980 Jan 1;151(1):91-100",
"pmid": "6985649"
},
{
"citation": "Nature. 1975 Aug 7;256(5517):495-7",
"pmid": "1172191"
},
{
"citation": "N Engl J Med. 1985 Aug 8;313(6):353-60",
"pmid": "3159965"
},
{
"citation": "Diabetologia. 1984 Jul;27 Suppl:102-5",
"pmid": "6237011"
},
{
"citation": "Diabetologia. 1981 Apr;20(4):471-4",
"pmid": "7016642"
},
{
"citation": "Lancet. 1984 Jul 7;2(8393):4-6",
"pmid": "6145952"
},
{
"citation": "Clin Endocrinol Metab. 1977 Jul;6(2):305-32",
"pmid": "330037"
},
{
"citation": "Diabetologia. 1983 Sep;25(3):247-51",
"pmid": "6227512"
},
{
"citation": "Diabetologia. 1985 Apr;28(4):195-203",
"pmid": "3160627"
},
{
"citation": "Diabetes. 1983 Jan;32(1):91-4",
"pmid": "6600223"
}
] | false | eng | Klin Wochenschr | 2985205R | 0023-2173 | Germany | [] | "2024-08-13T08:46:10.383816Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Proteases and antiproteases related to the coagulation system in plasma and ascites--influence of dexamethasone. | 65(14) | 639-42 | Fibrinolysis induced by the infusion of plasminogen activators into the circulation has been shown to cause coagulation disorders in ascites retransfusion. Dexamethasone is known to inhibit the synthesis of plasminogen activators by peritoneal macrophages. We therefore assessed its potential in preventing the occurrence of fibrinolysis by injecting 16 mg dexamethasone intraperitoneally in 10 patients 24 h before ascites retransfusion was performed. In addition, the effect of dexamethasone upon the activity or concentration of several proteases and antiproteases related to coagulation in plasma and ascites was analyzed on 15 occasions. An increase of the activity of plasminogen, alpha 2-antiplasmin, and antithrombin III, and in the concentration of alpha 1-protease inhibitor in ascites was induced by the dexamethasone injection. However, the reaction was not identical in all patients. Those patients having an increase of plasminogen activities of 0.6 CTA U/ml or more did not show signs of fibrinolysis during retransfusion. The results obtained indicate that intraperitoneal injection of dexamethasone decreases the concentration of plasminogen activators in ascites and thereby reduces the risk of coagulation disorders during retransfusion procedures. Since the effect is variable and not sustained, assessment of preoperative plasminogen concentrations is mandatory in order to prevent complications. | Klinische Wochenschrift | [
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Schölmerich"
},
{
"affiliation": "",
"forename": "U",
"identifier": "",
"initials": "U",
"lastname": "Zimmermann"
},
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Köttgen"
},
{
"affiliation": "",
"forename": "B A",
"identifier": "",
"initials": "BA",
"lastname": "Volk"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Hasler"
},
{
"affiliation": "",
"forename": "W",
"identifier": "",
"initials": "W",
"lastname": "Diener"
},
{
"affiliation": "",
"forename": "W",
"identifier": "",
"initials": "W",
"lastname": "Gerok"
}
] | 1987-07-15 | 3306136 | D000990:Antithrombin III / Q000378:metabolism; D001201:Ascites / Q000188:drug therapy* / Q000201:enzymology; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001780:Blood Coagulation Tests; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D008297:Male; D010447:Peptide Hydrolases / Q000097:blood*; D010536:Peritoneovenous Shunt; D010958:Plasminogen / Q000378:metabolism; D011480:Protease Inhibitors / Q000097:blood*; D000979:alpha-2-Antiplasmin / Q000378:metabolism | D016428:Journal Article | D001779:Blood Coagulation Factors; D005338:Fibrin Fibrinogen Degradation Products; D011480:Protease Inhibitors; D000979:alpha-2-Antiplasmin; D003907:Dexamethasone; D000990:Antithrombin III; D010958:Plasminogen; D010447:Peptide Hydrolases | 10.1007/BF01875498 | [
{
"citation": "J Exp Med. 1974 Oct 1;140(4):995-1010",
"pmid": "4427092"
},
{
"citation": "Thromb Haemost. 1983 Apr 28;49(2):128-31",
"pmid": "6868009"
},
{
"citation": "J Hepatol. 1988 Jun;6(3):359-63",
"pmid": "2455746"
},
{
"citation": "Gastroenterology. 1981 Apr;80(4):647-54",
"pmid": "7009306"
},
{
"citation": "Am J Surg. 1981 Jul;142(1):51-5",
"pmid": "7258515"
},
{
"citation": "Gastroenterology. 1982 Apr;82(4):790-9",
"pmid": "7037522"
},
{
"citation": "Klin Wochenschr. 1987 Jul 15;65(14):634-8",
"pmid": "2442449"
},
{
"citation": "J Reticuloendothel Soc. 1981 Aug;30(2):115-26",
"pmid": "7196953"
},
{
"citation": "Dtsch Med Wochenschr. 1985 Mar 29;110(13):512-8",
"pmid": "2579785"
},
{
"citation": "Cell. 1982 Mar;28(3):653-62",
"pmid": "6210439"
},
{
"citation": "Br J Haematol. 1975 Jul;30(3):311-6",
"pmid": "1201214"
},
{
"citation": "Dtsch Med Wochenschr. 1985 Nov 1;110(44):1685-91",
"pmid": "3876923"
},
{
"citation": "Aust N Z J Med. 1981 Feb;11(1):8-12",
"pmid": "6941784"
},
{
"citation": "Cell. 1976 Jun;8(2):271-81",
"pmid": "61067"
},
{
"citation": "J Immunol. 1981 Oct;127(4):1596-600",
"pmid": "7024410"
},
{
"citation": "Eur J Biochem. 1976 Oct 1;69(1):209-16",
"pmid": "136345"
},
{
"citation": "Proc Natl Acad Sci U S A. 1978 Dec;75(12):6130-3",
"pmid": "104300"
}
] | false | eng | Klin Wochenschr | 2985205R | 0023-2173 | Germany | [] | "2024-08-13T08:46:10.385501Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
[Reversible azathioprine associated dysmyeloproliferative syndrome after kidney allotransplantation]. | 65(13) | 620-4 | Three recipients of kidney allotransplants developed dysmyeloproliferative syndromes which were fully reversible after switching from azathioprine to cyclosporin A for immunosuppression. Similar bone marrow changes described in the literature progressed to leukemia. Whether the abnormalities observed in our patients could be early stages of the disease described in the literature and whether a fatal development can be prevented by changing the immunosuppressive therapy remains to be elucidated. | Klinische Wochenschrift | [
{
"affiliation": "",
"forename": "F",
"identifier": "",
"initials": "F",
"lastname": "Bammatter"
},
{
"affiliation": "",
"forename": "U",
"identifier": "",
"initials": "U",
"lastname": "Binswanger"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Fehr"
}
] | 1987-07-01 | 3306135 | D000328:Adult; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D001853:Bone Marrow / Q000187:drug effects*; D003524:Cyclosporins / Q000627:therapeutic use; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000187:drug effects; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced*; D011183:Postoperative Complications / Q000188:drug therapy* | D002363:Case Reports; D004740:English Abstract; D016428:Journal Article | D003524:Cyclosporins; D001379:Azathioprine | 10.1007/BF01726672 | [
{
"citation": "Transplant Proc. 1979 Mar;11(1):1047-51",
"pmid": "377608"
},
{
"citation": "Dtsch Med Wochenschr. 1969 Oct 31;94(44):2268-73",
"pmid": "5350093"
},
{
"citation": "Am J Kidney Dis. 1985 May;5(5):251-7",
"pmid": "3890527"
},
{
"citation": "JAMA. 1974 Mar 4;227(9):1036-40",
"pmid": "4405931"
},
{
"citation": "J Surg Res. 1980 Sep;29(3):258-64",
"pmid": "6997622"
},
{
"citation": "JAMA. 1978 Aug 11;240(6):552-4",
"pmid": "353309"
},
{
"citation": "Blut. 1980 May;40(5):343-8",
"pmid": "6994844"
}
] | false | ger | Reversibles Azathioprin assoziiertes dysmyeloproliferatives Syndrom nach Nierenallotransplantation. | Klin Wochenschr | 2985205R | 0023-2173 | Germany | [] | "2024-08-13T08:46:10.387043Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||
A reliable method for immunocytochemical characterization of CSF cells. | 65(14) | 664-6 | A technically convenient and reliable method for immunoenzymatic staining of cerebrospinal fluid (CSF) cells is described. Compared with immunofluorescence techniques this method has the advantage that the immunocytochemical preparations can be counterstained and stored indefinitely. | Klinische Wochenschrift | [
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Hohlfeld"
},
{
"affiliation": "",
"forename": "W",
"identifier": "",
"initials": "W",
"lastname": "Johanns"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Fahsbender"
},
{
"affiliation": "",
"forename": "K V",
"identifier": "",
"initials": "KV",
"lastname": "Toyka"
}
] | 1987-07-15 | 3306137 | D000911:Antibodies, Monoclonal; D002555:Cerebrospinal Fluid / Q000166:cytology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007958:Leukocyte Count; D013601:T-Lymphocytes / Q000145:classification* | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D000911:Antibodies, Monoclonal | 10.1007/BF01875501 | [
{
"citation": "Ann Neurol. 1986 Nov;20(5):610-5",
"pmid": "3539002"
},
{
"citation": "Lancet. 1983 Sep 24;2(8352):739-40",
"pmid": "6136866"
},
{
"citation": "Lancet. 1984 May 19;1(8386):1095-8",
"pmid": "6202990"
},
{
"citation": "Klin Wochenschr. 1983 Sep 15;61(18):933-4",
"pmid": "6226824"
},
{
"citation": "Dtsch Med Wochenschr. 1984 Nov 16;109(46):1760-2",
"pmid": "6437784"
},
{
"citation": "J Immunol Methods. 1983 Nov 11;64(1-2):85-90",
"pmid": "6358365"
}
] | false | eng | Klin Wochenschr | 2985205R | 0023-2173 | Germany | [] | "2024-08-13T08:46:10.388170Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
[High-dose chemoradiotherapy with bone marrow transplantation as a consolidation treatment of neuroblastoma. Results in 49 unselected patients with stage IV cancer and older than 1 year. Report of the LMCE neuroblastoma group]. | 199(3) | 218-23 | 65 consecutive children over one year of age presenting with neuroblastoma stage IV were unselectively treated with an induction regimen alternating Cis-Platinum/VM 26 and Cyclophosphamide/Adriamycin/Vincristin. After primary surgery two to four months post diagnosis, consolidation consisted of continuous Vincristin, high dose Melphalan and fractionated total body irradiation, followed by bone marrow transplantation (autologous except for 3 allogeneic). Of the 49 children transplanted up to evaluation date, 31 were in partial remission (PR) and 18 in "very good partial remission" (VGPR) or complete remission (CR) at the time of transplantation. The toxic mortality was 20% (14% early, 6% late), the relapse rate 29% and the progressive disease rate 6%. The event-free survival from graft (events being relapse, progression or death) was 33% after a median of 17 months (range: 2-45) without a significant difference between a status at transplantation of PR versus VGPR/CR. The overall actuarial progression-free survival of the complete group of children with neuroblastoma stage IV was 24% after 27 months, including 10 patients who died or relapsed before massive therapy as well as 6 children still in induction. This result must be compared with 6% survival in a similar group diagnosed at the same institutions and treated with conventional chemotherapy before the onset of this trial. | Klinische Padiatrie | [
{
"affiliation": "",
"forename": "B",
"identifier": "",
"initials": "B",
"lastname": "Kremens"
},
{
"affiliation": "",
"forename": "T",
"identifier": "",
"initials": "T",
"lastname": "Philip"
},
{
"affiliation": "",
"forename": "J L",
"identifier": "",
"initials": "JL",
"lastname": "Bernard"
},
{
"affiliation": "",
"forename": "J M",
"identifier": "",
"initials": "JM",
"lastname": "Zucker"
}
] | 1987 | 3306132 | D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D011879:Radiotherapy Dosage; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D014916:Whole-Body Irradiation | D004740:English Abstract; D016428:Journal Article | 10.1055/s-2008-1026793 | [] | false | ger | Hochdosierte Chemoradiotherapie mit Knochenmarkstransplantation als Konsolidierungsbehandlung beim Neuroblastom. Ergebnisse bei 49 unselektionierten Patienten mit Stadium IV und älter als ein Jahr. Ein Bericht von der LMCE-Neuroblastom Gruppe. | Klin Padiatr | 0326144 | 0300-8630 | Germany | [] | "2024-08-13T08:46:10.390188Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Natural IFN-alpha therapy in hairy-cell leukaemia (namalva-type IFN--Wellferon). | 65(14) | 685-7 | More than 50 patients with hairy-cell leukaemia have now been entered into the British Wellferon (IFN) study, at different centres under the coordination of the Wellcome Research Laboratories. While the treatment duration and dosage varied between patients, the initial dose was usually 3 megaunits daily by intramuscular or subcutaneous injection. Although flu-like symptoms and mild somnolence were commonly experienced side-effects; cessation of IFN treatment as a result of such effects was necessary in only three patients. All patients irrespective of previous treatment showed some response and a complete (less than 5% hairy cells, HCs) bone marrow response was observed in 17. The degree of response was related to the duration of therapy. Immunological markers showed that there was no apparent increase in natural killer (NK) cells and no return of normal B lymphocytes. Light-chain-restricted B cells became reduced in parallel with the disappearance of morphological HCs. Absolute numbers of T cells were reduced, Leu2a+ preferentially, resulting in an increase in helper/suppressor ratios. The ratios (saturation index, SI) of saturated to unsaturated 18 carbon fatty acids (C18FA) of erythrocyte or leukocyte membranes, while abnormal in untreated patients, approached normal levels during IFN therapy. It is concluded that prolonged alpha IFN therapy is highly effective in HCL. The mechanism of action of IFN remains unknown, but indirect surface-marker data favours a direct effect on HCs. | Klinische Wochenschrift | [
{
"affiliation": "",
"forename": "C P",
"identifier": "",
"initials": "CP",
"lastname": "Worman"
},
{
"affiliation": "",
"forename": "A B",
"identifier": "",
"initials": "AB",
"lastname": "Nethersell"
},
{
"affiliation": "",
"forename": "J M",
"identifier": "",
"initials": "JM",
"lastname": "Bottomley"
},
{
"affiliation": "",
"forename": "K",
"identifier": "",
"initials": "K",
"lastname": "Apostolov"
},
{
"affiliation": "",
"forename": "W",
"identifier": "",
"initials": "W",
"lastname": "Barker"
},
{
"affiliation": "",
"forename": "J C",
"identifier": "",
"initials": "JC",
"lastname": "Cawley"
}
] | 1987-07-15 | 3306138 | D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects / Q000627:therapeutic use*; D007943:Leukemia, Hairy Cell / Q000628:therapy*; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D008875:Middle Aged; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use* | D016430:Clinical Trial; D016428:Journal Article | D005227:Fatty Acids; D007370:Interferon Type I; D008563:Membrane Lipids; D011994:Recombinant Proteins | 10.1007/BF01875506 | [
{
"citation": "Cancer Res. 1979 Feb;39(2 Pt 1):426-35",
"pmid": "761216"
},
{
"citation": "Leukemia. 1987 Apr;1(4):379-82",
"pmid": "3669764"
},
{
"citation": "Br J Haematol. 1985 Aug;60(4):759-63",
"pmid": "3875366"
},
{
"citation": "Blut. 1985 Jun;50(6):349-54",
"pmid": "3859340"
},
{
"citation": "N Engl J Med. 1984 Jan 5;310(1):15-8",
"pmid": "6689734"
}
] | false | eng | Klin Wochenschr | 2985205R | 0023-2173 | Germany | [] | "2024-08-13T08:46:10.391373Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
[Beta interferon therapy in hairy cell leukemia]. | 65(14) | 688-90 | Eleven patients with histologically proven hairy-cell leukemia were treated for 2 to 6 months with a natural beta-interferon (beta-IFN) preparation (3 X 4 million units week i.v.). Three of the eight evaluable patients experienced a partial response, two a minor response, and three no improvement. A reduction of the hairy-cell infiltration of the bone marrow was observed in one patient. Typical IFN side-effects with flu-like symptoms were noted. These results demonstrate that IFN-beta has some clinical efficacy in hairy-cell leukemia. | Klinische Wochenschrift | [
{
"affiliation": "",
"forename": "P",
"identifier": "",
"initials": "P",
"lastname": "von Wussow"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Dühlmann"
},
{
"affiliation": "",
"forename": "T",
"identifier": "",
"initials": "T",
"lastname": "Grethlein"
},
{
"affiliation": "",
"forename": "W D",
"identifier": "",
"initials": "WD",
"lastname": "Hirschmann"
},
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Hügl"
},
{
"affiliation": "",
"forename": "O",
"identifier": "",
"initials": "O",
"lastname": "Koch"
},
{
"affiliation": "",
"forename": "W R",
"identifier": "",
"initials": "WR",
"lastname": "Martin"
},
{
"affiliation": "",
"forename": "H W",
"identifier": "",
"initials": "HW",
"lastname": "Pees"
},
{
"affiliation": "",
"forename": "W",
"identifier": "",
"initials": "W",
"lastname": "Urbanitz"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Freund"
}
] | 1987-07-15 | 3306139 | D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects / Q000627:therapeutic use*; D007943:Leukemia, Hairy Cell / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction | D016430:Clinical Trial; D004740:English Abstract; D016428:Journal Article | D007370:Interferon Type I | 10.1007/BF01875507 | [
{
"citation": "Klin Wochenschr. 1987 Jul 15;65(14):706-12",
"pmid": "3114551"
},
{
"citation": "Clin Pharmacol Ther. 1984 May;35(5):722-7",
"pmid": "6713784"
},
{
"citation": "Blut. 1986 May;52(5):265-72",
"pmid": "3635415"
},
{
"citation": "Lancet. 1984 May 5;1(8384):1025-6",
"pmid": "6143957"
},
{
"citation": "Proc Natl Acad Sci U S A. 1984 Sep;81(17):5504-8",
"pmid": "6206498"
},
{
"citation": "Blood. 1985 Mar;65(3):644-8",
"pmid": "3971043"
},
{
"citation": "Philos Trans R Soc Lond B Biol Sci. 1982 Sep 24;299(1094):91-107",
"pmid": "6183699"
},
{
"citation": "Br J Haematol. 1985 Aug;60(4):759-63",
"pmid": "3875366"
},
{
"citation": "Blood. 1985 Apr;65(4):1017-20",
"pmid": "3884059"
},
{
"citation": "N Engl J Med. 1984 Jan 5;310(1):15-8",
"pmid": "6689734"
}
] | false | ger | IFN-beta-Therapie bei der Haarzelleukämie. | Klin Wochenschr | 2985205R | 0023-2173 | Germany | [] | "2024-08-13T08:46:10.392961Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||
[General symptomatology of enteritis and colitis (the 90th anniversary of presenting enteritis as a separate clinical entity]. | 65(6) | 146-9 | Klinicheskaia meditsina | [
{
"affiliation": "",
"forename": "V P",
"identifier": "",
"initials": "VP",
"lastname": "Obraztsov"
}
] | 1987-06 | 3306140 | D003092:Colitis / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004751:Enteritis / Q000175:diagnosis*; D004760:Enterocolitis / Q000175:diagnosis*; D005762:Gastroenterology / Q000266:history*; D049672:History, 19th Century; D049673:History, 20th Century; D009626:Terminology as Topic | D003160:Comparative Study; D016456:Historical Article; D016428:Journal Article | [] | false | rus | K obshcheĭ simptomatologii énteritov i kolitov (k 90-letiiu vydeleniia kliniki énteritov). | Klin Med (Mosk) | 2985204R | 0023-2149 | Russia (Federation) | [] | "2024-08-13T08:46:10.393945Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
[Medulloblastoma therapy studies MBL 80 and MED 84 of the Society of Pediatric Oncology and the Société Internationale d'Oncologie Pédiatrique (SIOP)]. | 199(3) | 188-92 | In both trials the principle of "sandwich" chemotherapy (administered between surgery and postoperative irradiation) is studied in medulloblastoma. GPO-MBL 80 was essentially a one-arm trial; results after a mean observation period of 3 years show an expected event-free survival rate of 46% at 6 years. "Maintenance" chemotherapy with CCNU and vincristine did not further improve the results. Preliminary results of the joint, prospective, randomised forearm SIOP-GPO trial MED 84 are presented. It is apparently too early to answer any of the two main questions asked by this trial: a) is "sandwich" chemotherapy (as administered) of any value? b) can radiotherapy doses to the supratentorial area and to the spine be moderately reduced in so-called "low risk" patients without compromising long-term results? Thus far, we cannot observe any prognostic influence of the "classical" risk factors as established by other studies. | Klinische Padiatrie | [
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Neidhardt"
},
{
"affiliation": "",
"forename": "C C",
"identifier": "",
"initials": "CC",
"lastname": "Bailey"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Gnekow"
},
{
"affiliation": "",
"forename": "P",
"identifier": "",
"initials": "P",
"lastname": "Kleihues"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Michaelis"
},
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Wellek"
}
] | 1987 | 3306131 | D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002528:Cerebellar Neoplasms / Q000188:drug therapy* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008527:Medulloblastoma / Q000188:drug therapy* / Q000601:surgery; D008727:Methotrexate / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D011897:Random Allocation; D014750:Vincristine / Q000008:administration & dosage | D016430:Clinical Trial; D004740:English Abstract; D016428:Journal Article; D016449:Randomized Controlled Trial | D011344:Procarbazine; D014750:Vincristine; D002955:Leucovorin; D008727:Methotrexate | 10.1055/s-2008-1026787 | [] | false | ger | Die Medulloblastom-Therapiestudien MBL 80 und MED 84 der Gesellschaft für Pädiatrische Onkologie (GPO) und der Société Internationale d'Oncologie Pédiatrique (SIOP). | Klin Padiatr | 0326144 | 0300-8630 | Germany | [] | "2024-08-13T08:46:10.396174Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||
[Peptic ulcer and hereditary constitutional factors]. | 65(6) | 31-5 | Klinicheskaia meditsina | [
{
"affiliation": "",
"forename": "A A",
"identifier": "",
"initials": "AA",
"lastname": "Sheptulin"
}
] | 1987-06 | 3306141 | D001824:Body Constitution; D004198:Disease Susceptibility; D006801:Humans; D010437:Peptic Ulcer / Q000209:etiology / Q000235:genetics* | D016428:Journal Article; D016454:Review | [] | false | rus | Iazvennaia bolezn' i nasledstvenno-konstitutsional'nye. | Klin Med (Mosk) | 2985204R | 0023-2149 | Russia (Federation) | [] | "2024-08-13T08:46:10.396929Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
[Cimetidine treatment of gastroduodenal erosions and ulcers]. | 65(6) | 56-9 | Klinicheskaia meditsina | [
{
"affiliation": "",
"forename": "V D",
"identifier": "",
"initials": "VD",
"lastname": "Vodolagin"
},
{
"affiliation": "",
"forename": "L I",
"identifier": "",
"initials": "LI",
"lastname": "Tsvetkova"
},
{
"affiliation": "",
"forename": "A P",
"identifier": "",
"initials": "AP",
"lastname": "Ettinger"
},
{
"affiliation": "",
"forename": "A Iu",
"identifier": "",
"initials": "AIu",
"lastname": "Tsibulevskiĭ"
}
] | 1987-06 | 3306142 | D000293:Adolescent; D000328:Adult; D000818:Animals; D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy*; D051381:Rats | D016430:Clinical Trial; D004740:English Abstract; D016428:Journal Article | D002927:Cimetidine | [] | false | rus | Terapiia tsimetidinom gastroduodenal'nykh éroziĭ i iazv. | Klin Med (Mosk) | 2985204R | 0023-2149 | Russia (Federation) | [] | "2024-08-13T08:46:10.397722Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[Ultrasonic examination of the stomach]. | 65(6) | 67-71 | Klinicheskaia meditsina | [
{
"affiliation": "",
"forename": "Z A",
"identifier": "",
"initials": "ZA",
"lastname": "Lemeshko"
}
] | 1987-06 | 3306143 | D000328:Adult; D006801:Humans; D008297:Male; D013270:Stomach / Q000473:pathology; D013272:Stomach Diseases / Q000175:diagnosis*; D014463:Ultrasonography | D002363:Case Reports; D004740:English Abstract; D016428:Journal Article | [] | false | rus | Ob ul'trazvukovom issledovanii zheludka. | Klin Med (Mosk) | 2985204R | 0023-2149 | Russia (Federation) | [] | "2024-08-13T08:46:10.398697Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
[V. P. Obraztsov (on the centenary of description of methodical deep sliding palpation of the abdominal organs]. | 65(6) | 7-16 | Klinicheskaia meditsina | [
{
"affiliation": "",
"forename": "V Kh",
"identifier": "",
"initials": "VKh",
"lastname": "Vasilenko"
}
] | 1987-06 | 3306144 | D000005:Abdomen; D004066:Digestive System Diseases / Q000175:diagnosis*; D005762:Gastroenterology / Q000266:history; D049672:History, 19th Century; D049673:History, 20th Century; D010173:Palpation / Q000379:methods*; D012425:Russia (Pre-1917); D014586:USSR | D019215:Biography; D016456:Historical Article; D016428:Journal Article; D019477:Portrait | [] | false | rus | V. P. Obraztsov (k stoletiiu opisaniia metodichnoĭ glubokoi skol'ziashcheĭ pal'patsii organov briushnoĭ polosti). | Klin Med (Mosk) | 2985204R | 0023-2149 | Russia (Federation) | [] | "2024-08-13T08:46:10.399363Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Animal research protocol review in the Veterans Administration. | 37 Spec No() | 137-9 | Laboratory animal science | [
{
"affiliation": "",
"forename": "A F",
"identifier": "",
"initials": "AF",
"lastname": "Moreland"
}
] | 1987-01 | 3306145 | D000827:Animal Welfare; D000818:Animals; D000830:Animals, Laboratory; D011367:Professional Staff Committees; D012106:Research; D014481:United States; D014493:United States Department of Veterans Affairs | D016428:Journal Article | [] | false | eng | Lab Anim Sci | 1266503 | 0023-6764 | United States | [] | "2024-08-13T08:46:10.400148Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
Animal Care and Use Committees: history and current national policies in the United States. | 37 Spec No() | 18-21 | Laboratory animal science | [
{
"affiliation": "",
"forename": "R A",
"identifier": "",
"initials": "RA",
"lastname": "Whitney"
}
] | 1987-01 | 3306146 | D000827:Animal Welfare / Q000266:history*; D000818:Animals; D000830:Animals, Laboratory; D049673:History, 20th Century; D009316:National Institutes of Health (U.S.); D011367:Professional Staff Committees / Q000266:history*; D012106:Research; D014481:United States; D014492:United States Public Health Service | D016456:Historical Article; D016428:Journal Article | [] | false | eng | Lab Anim Sci | 1266503 | 0023-6764 | United States | [] | "2024-08-13T08:46:10.400827Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
Case studies of ethical dilemmas: Animal Care and Use Committee. | 37 Spec No() | 59-64 | Laboratory animal science | [
{
"affiliation": "",
"forename": "F B",
"identifier": "",
"initials": "FB",
"lastname": "Orlans"
}
] | 1987-01 | 3306147 | D000827:Animal Welfare; D000818:Animals; D000830:Animals, Laboratory; D016025:Bone Transplantation; D062109:Dermatologic Surgical Procedures; D004989:Ethics; D005221:Fatigue; D006795:Household Products / Q000633:toxicity; D011367:Professional Staff Committees; D012106:Research; D013623:Tail / Q000293:injuries; D014786:Vision Disorders | D016428:Journal Article | Biomedical and Behavioral Research | [] | false | eng | 120684; VF 22.2 | Lab Anim Sci | 1266503 | 0023-6764 | United States | [] | "2024-08-13T08:46:10.402542Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Carbohydrate abnormalities of N-linked plasma glycoproteins in liver disease. | 57(3) | 240-57 | Glycoproteins are proteins with covalently attached carbohydrate which is enzymatically added during the biosynthesis of the polypeptide. Attachment of carbohydrate to the polypeptide may involve either an N-glycosidic or an O-glycosidic bond. Most of the plasma glycoproteins have N-linked oligosaccharides attached to appropriate asparagine moieties of the peptide core. The biosynthesis of the N-linked glycoproteins proceeds through three sequential phases which include (a) dolichol-mediated oligosaccharide assembly, (b) oligosaccharide linkage to the polypeptide, and (c) oligosaccharide processing with the addition of peripheral sugars. Much of the diversity in carbohydrate structure of plasma glycoproteins results from variations in processing and addition of peripheral sugars. The terminal monosaccharide of N-linked plasma glycoproteins is usually sialic acid, a negatively charged sugar which markedly affects the physicochemical and biologic characteristics of glycoproteins. Liver disease induces alterations in both the level and structure of many plasma glycoproteins, particularly those which are synthesized by the hepatocyte. Quantitative changes in the concentration of plasma glycoproteins are relatively easy to assess due to the availability of many types of clinical assays. Furthermore, quantitation of the level of a particular glycoprotein in the plasma often provides clinically useful information pertinent to diagnosis and progression of disease. The determination of functional abnormalities of glycoproteins and the correlation of these functional changes with potential alterations in carbohydrate structure is more difficult, however, due to the need for accurate functional assays and sophisticated methods for analysis of the carbohydrate structure of the abnormal molecules, which are themselves often scarce. Liver disease-induced alterations in the oligosaccharide moieties of plasma glycoproteins involve mainly hyperglycosylation or hypoglycosylation defects. These changes can often be traced to increases or decreases in the amount of sialic acid present within the abnormal structure. Since sialic acid plays such a key role in the biology of glycoproteins, changes in the amount of this monosaccharide frequently result in marked alterations in the physicochemical and biologic behavior of the abnormal molecule. The exact mechanisms responsible for the changes in sialic acid are not entirely known, since the complete oligosaccharide structure of any of the abnormal glycoproteins of liver disease has not been determined.(ABSTRACT TRUNCATED AT 400 WORDS) | Laboratory investigation; a journal of technical methods and pathology | [
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Martinéz"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Barsigian"
}
] | 1987-09 | 3306148 | D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006023:Glycoproteins / Q000096:biosynthesis / Q000097:blood* / Q000235:genetics; D006801:Humans; D008107:Liver Diseases / Q000097:blood* / Q000235:genetics | D016428:Journal Article; D013487:Research Support, U.S. Gov't, P.H.S.; D016454:Review | D006023:Glycoproteins | [] | false | eng | Lab Invest | 0376617 | 0023-6837 | United States | [
{
"agency": "NHLBI NIH HHS",
"country": "United States",
"grant_acronym": "HL",
"grant_id": "HL-20092"
}
] | "2024-08-13T08:46:10.403242Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
The role of mesangial complement in the hematuria of experimental IgA nephropathy. | 57(3) | 269-76 | We sought to determine if codeposits of IgG and IgM and glomerular complement, observed in most cases of human IgA nephropathy, might be important for inducing hematuria. All combinations of three binary variables, the protein immunogen, the duration of oral immunization, and the protein used for intravenous challenge, were accommodated by eight groups of BALB/c mice in an active model of IgA nephropathy. Mice drank 0.1% solutions of either of two proteins for either 6 or 14 weeks, and then were challenged intravenously with either the same protein or the alternate protein. After 6 weeks, all mice had significant increases of serum IgA, IgG, and IgM antibody to the oral immunogen. At 14 weeks, IgG and IgM antibodies were reduced, presumably due to the onset of oral tolerance, but IgA titers persisted. Nearly all mice had mesangial deposits of IgA and oral immunogen. However, only mice immunized for 6 weeks and challenged with the same protein had significant IgG and IgM deposits (100%), C3 deposits (76%), and significant microhematuria. To distinguish between the role of IgG/IgM codeposits and C3 in the pathogenesis of the hematuria, we induced passive IgA nephropathy with immune complexes of monoclonal IgA anti-dinitrophenyl antibody, dinitrophenyl-bovine albumin as antigen, and one of two monoclonal IgG antibodies specific for dinitrophenyl; one of the IgGs fixes complement, the other does not. Despite comparable mesangial deposits of IgA, IgG, and antigen, only mice given immune complexes containing the complement-fixing IgG had glomerular C3 and hematuria. Furthermore, when mice depleted of serum complement via cobra venom factor were given immune complexes containing the complement-fixing IgG, no glomerular complement was observed and no hematuria ensued. We conclude that IgG/IgM codeposits in murine IgA nephropathy do not directly cause hematuria but do induce the deposition of complement, which is in turn required for glomerular injury. | Laboratory investigation; a journal of technical methods and pathology | [
{
"affiliation": "",
"forename": "S N",
"identifier": "",
"initials": "SN",
"lastname": "Emancipator"
},
{
"affiliation": "",
"forename": "Z",
"identifier": "",
"initials": "Z",
"lastname": "Ovary"
},
{
"affiliation": "",
"forename": "M E",
"identifier": "",
"initials": "ME",
"lastname": "Lamm"
}
] | 1987-09 | 3306149 | D000818:Animals; D003176:Complement C3 / Q000032:analysis*; D004195:Disease Models, Animal; D005260:Female; D005455:Fluorescent Antibody Technique; D005922:Glomerulonephritis, IGA / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D006417:Hematuria / Q000209:etiology*; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D008807:Mice, Inbred BALB C | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't; D013487:Research Support, U.S. Gov't, P.H.S. | D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G | [] | false | eng | Lab Invest | 0376617 | 0023-6837 | United States | [
{
"agency": "NCI NIH HHS",
"country": "United States",
"grant_acronym": "CA",
"grant_id": "CA-32582"
},
{
"agency": "NIDDK NIH HHS",
"country": "United States",
"grant_acronym": "DK",
"grant_id": "DK-38544"
},
{
"agency": "NHLBI NIH HHS",
"country": "United States",
"grant_acronym": "HL",
"grant_id": "HL-37117"
}
] | "2024-08-13T08:46:10.404473Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Clip-ablation. A model of experimental hypertension in the rat. | 57(3) | 291-6 | A model of experimental hypertension has been developed in which the features of the two kidney-one clip and renal ablation models are combined in a single rat. It has been designated the clip-ablation model. It is produced by the placement of a silver clip with an opening of 0.13 mm on a branch of the left renal artery supplying one-third of that kidney, followed by right nephrectomy. In this way the effects of renin-dependent hypertension may be studied in glomeruli which are undergoing compensatory changes in response to reduction in renal mass. Clip-ablation rats were compared to rats with 1 1/3 reduction of renal mass at various intervals up to 28 days after operation. Systolic blood pressure rose with increasing time after operation in both groups with the increase being greater in the clip-ablation rats (177 +/- 10 mm Hg) as compared to the ablation rats (153 +/- 6 mm Hg) at 28 days. Plasma renin activity was increased slightly at 3 days in the ablation rats but had returned to normal levels by 28 days. By contrast, the plasma renin activity rose throughout the experimental period in the clip-ablation rats and attained a level of 32.3 +/- 8.0 ng/ml/hour by 28 days. Urine protein was significantly higher than normal only in the 28-day clip ablation rats (71.2 +/- 23.9 mg/24 hour). Glomerular damage index (GDI), a measure of glomerular injury, increased with longer intervals from operation in both experimental groups, paralleling the rise in systolic blood pressure. Beginning on day 14 and onward the GDI was always numerically higher in the clip-ablation rats than in the ablation rats. Stepwise multiple regression analysis indicated that the strongest predictor of GDI was the change in blood pressure. Plasma renin activity had an additional independent effect on GDI in the clip-ablation rats. The finding of more glomerular damage in the clip-ablation rats than in those with simple removal of comparable amounts of renal tissue is in contrast to the lesser amount of damage found in the two kidney-one clip model when compared with the model of removal of renal substance. It is likely that the compensatory hemodynamic changes in response to reduction in renal mass in the glomeruli of clip-ablation rats make them more vulnerable to injury when exposed to a renin-angiotensin induced hypertension. | Laboratory investigation; a journal of technical methods and pathology | [
{
"affiliation": "",
"forename": "J L",
"identifier": "",
"initials": "JL",
"lastname": "Olson"
},
{
"affiliation": "",
"forename": "J K",
"identifier": "",
"initials": "JK",
"lastname": "Boitnott"
},
{
"affiliation": "",
"forename": "R H",
"identifier": "",
"initials": "RH",
"lastname": "Heptinstall"
}
] | 1987-09 | 3306150 | D000818:Animals; D001794:Blood Pressure; D004195:Disease Models, Animal; D006978:Hypertension, Renovascular / Q000473:pathology / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D011507:Proteinuria; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood | D003160:Comparative Study; D016428:Journal Article; D013487:Research Support, U.S. Gov't, P.H.S. | D012083:Renin | [] | false | eng | Lab Invest | 0376617 | 0023-6837 | United States | [
{
"agency": "NHLBI NIH HHS",
"country": "United States",
"grant_acronym": "HL",
"grant_id": "HL 07835"
}
] | "2024-08-13T08:46:10.405455Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Serotonin release is mediated by muscarinic receptors on duodenal mucosal cells. | 43(2) | 139-42 | Serotonin (5-HT), found in abundance in intestinal enterochromaffin cells, has been shown to be released in response to neural, humoral, and intraluminal stimuli but the mechanisms controlling release are poorly understood. The purpose of this study was to determine whether 5-HT release induced by the muscarinic agonist, methacholine, is mediated by enteric nerves or is a direct action at the mucosal cell level. We mounted rabbit mucosal sheets containing intact submucosal neural elements, but stripped of muscularis propria and myenteric plexus, in modified Ussing chambers and measured the release of 5-HT in response to 5 X 10(-5) M methacholine added to both mucosal and serosal surface bathing solutions, in the presence and absence of selective neural blockade with 1 X 10(-6) M tetrodotoxin. 5-HT release in control tissues (no drugs) as measured by radioimmunoassay was 25.7 +/- 6 ng/cm2/30 min (mean +/- SEM). In the presence of mucosal and serosal methacholine, total 5-HT release increased significantly (P less than 0.05) to 66.7 +/- 9 ng/cm2/30 min. When tetrodotoxin alone was applied, 5-HT release significantly increased to 55.2 +/- 9 ng/cm2/30 min compared to matched control. In the presence of tetrodotoxin, methacholine increased 5-HT release to 79.3 +/- 9 ng/cm2/30 min, which was significantly greater than with tetrodotoxin alone. These results provide evidence of an inhibitory neural regulation of basal 5-HT release since release increased in the presence of neural blockade. They also suggest that a muscarinic receptor at or near the enterochromaffin cells mediates mucosal 5-HT release since 5-HT is further increased by methacholine even in the presence of neural blockade. | The Journal of surgical research | [
{
"affiliation": "",
"forename": "J F",
"identifier": "",
"initials": "JF",
"lastname": "Kuemmerle"
},
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Kraus"
},
{
"affiliation": "",
"forename": "J M",
"identifier": "",
"initials": "JM",
"lastname": "Kellum"
}
] | 1987-08 | 3306152 | D000818:Animals; D004386:Duodenum / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000494:pharmacology; D011817:Rabbits; D011976:Receptors, Muscarinic / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology | D016428:Journal Article | D008688:Methacholine Compounds; D011976:Receptors, Muscarinic; D016210:Methacholine Chloride; D012701:Serotonin; D013779:Tetrodotoxin | 10.1016/0022-4804(87)90156-9 | [] | false | eng | J Surg Res | 0376340 | 0022-4804 | United States | [] | "2024-08-13T08:46:10.406857Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Factors influencing enlargement rate of small abdominal aortic aneurysms. | 43(3) | 211-9 | The purpose of this study was to determine the factors influencing enlargement rate of small abdominal aortic aneurysms. Fifty-seven high-risk patients with asymptomatic abdominal aortic aneurysms initially measuring 3.5 to 5.9 cm in the largest transverse diameter were followed with serial echographic measurements for 6 to 78 months (mean 24). The mean enlargement rate (MER) and the occurrence of sudden change in size (SCS) for each aneurysm were correlated to 23 variables. MER ranged from 0 to 1.8 cm/year (mean 0.48). During the study period 17 aneurysms showed SCS. The results of univariate analysis indicated that 8 variables were statistically correlated to the degree of MER and 5 to the occurrence of SCS. A multiple regression model was generated by stepwise regression analysis and demonstrated that 2 variables were independent predictors of the degree of MER: (1) the absence of distal arterial occlusive disease and (2) the ratio of the diameter of the aneurysm to that of the aorta (RD). The overall model P value was less than 0.001. A statistically valid multiple regression model to predict the occurrence of SCS was not feasible (P = 1.0). We conclude that the occurrence of SCS of small abdominal aortic aneurysms is often unpredictable and that the RD rather than the value of the aneurysmal diameter per se must be considered in selecting high-risk patients for echographic follow-up. | The Journal of surgical research | [
{
"affiliation": "",
"forename": "A V",
"identifier": "",
"initials": "AV",
"lastname": "Sterpetti"
},
{
"affiliation": "",
"forename": "R D",
"identifier": "",
"initials": "RD",
"lastname": "Schultz"
},
{
"affiliation": "",
"forename": "R J",
"identifier": "",
"initials": "RJ",
"lastname": "Feldhaus"
},
{
"affiliation": "",
"forename": "S E",
"identifier": "",
"initials": "SE",
"lastname": "Cheng"
},
{
"affiliation": "",
"forename": "D J",
"identifier": "",
"initials": "DJ",
"lastname": "Peetz"
}
] | 1987-09 | 3306154 | D000368:Aged; D001012:Aorta, Abdominal; D001014:Aortic Aneurysm / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D011379:Prognosis; D014463:Ultrasonography | D016428:Journal Article | 10.1016/0022-4804(87)90073-4 | [] | false | eng | J Surg Res | 0376340 | 0022-4804 | United States | [] | "2024-08-13T08:46:10.408913Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Animal models of pigment gallstone disease. | 43(2) | 196-203 | The Journal of surgical research | [
{
"affiliation": "",
"forename": "R V",
"identifier": "",
"initials": "RV",
"lastname": "Rege"
},
{
"affiliation": "",
"forename": "D L",
"identifier": "",
"initials": "DL",
"lastname": "Nahrwold"
}
] | 1987-08 | 3306153 | D000745:Anemia, Hemolytic, Congenital / Q000150:complications; D000818:Animals; D001646:Bile / Q000032:analysis; D002769:Cholelithiasis / Q000503:physiopathology*; D006224:Cricetinae; D004032:Diet; D004195:Disease Models, Animal; D004285:Dogs; D006168:Guinea Pigs; D008034:Lincomycin / Q000009:adverse effects; D008106:Liver Cirrhosis, Experimental / Q000150:complications; D012589:Sciuridae | D016428:Journal Article; D013486:Research Support, U.S. Gov't, Non-P.H.S.; D016454:Review | D008034:Lincomycin | 10.1016/0022-4804(87)90164-8 | [] | false | eng | J Surg Res | 0376340 | 0022-4804 | United States | [] | "2024-08-13T08:46:10.409778Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Insulin response following intravenous glucose administration in dogs with obstructive jaundice. | 43(3) | 271-7 | In order to further clarify the circulating insulin kinetics in obstructive jaundice, five anesthetized dogs were given a 15-min intravenous infusion of 1 g/kg glucose before and during the first 1 to 2 weeks after a common bile duct ligation. Significantly higher blood glucose levels, a lower insulin response in femoral vein blood, and a lower initial insulin response in portal vein blood were observed following glucose administration in the animals with jaundice. The ratio of (integrated portal insulin response-integrated femoral insulin response)/(integrated portal insulin response) was significantly increased in the animals with jaundice when compared with that of the control animals. These results suggest that a low peripheral insulin response following glucose administration in obstructive jaundice is induced by an augmented insulin extraction in the liver and/or peripheral tissue as well as by an insulin hyposecretion from the pancreas. | The Journal of surgical research | [
{
"affiliation": "",
"forename": "K",
"identifier": "",
"initials": "K",
"lastname": "Yoshiya"
},
{
"affiliation": "",
"forename": "T",
"identifier": "",
"initials": "T",
"lastname": "Kishimoto"
},
{
"affiliation": "",
"forename": "Y",
"identifier": "",
"initials": "Y",
"lastname": "Ishikawa"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Utsunomiya"
}
] | 1987-09 | 3306155 | D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002779:Cholestasis / Q000097:blood*; D004285:Dogs; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D011168:Portal System / Q000503:physiopathology | D016428:Journal Article | D001786:Blood Glucose; D007328:Insulin; D005947:Glucose | 10.1016/0022-4804(87)90081-3 | [] | false | eng | J Surg Res | 0376340 | 0022-4804 | United States | [] | "2024-08-13T08:46:10.410609Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Non-surgical periodontal therapy for AIDS patient with periodontal involvement. A periodontal case management in a general practice. | 67(2) | 41-3 | The Journal of the Tennessee Dental Association | [
{
"affiliation": "",
"forename": "S A",
"identifier": "",
"initials": "SA",
"lastname": "Doherty"
}
] | 1987-04 | 3306156 | D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D001207:Asepsis; D012534:Dental Scaling; D005882:Gingival Diseases / Q000628:therapy*; D006801:Humans; D008297:Male; D010353:Patient Education as Topic; D010510:Periodontal Diseases / Q000628:therapy*; D014092:Tooth Root / Q000601:surgery | D002363:Case Reports; D016428:Journal Article | [] | false | eng | J Tenn Dent Assoc | 7503125 | 0040-3385 | United States | [] | "2024-08-13T08:46:10.411595Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
Tennessee Dental Association. Directory and membership roster 1987-1988. | 67(3) | 17-43 | The Journal of the Tennessee Dental Association | [] | 1987-07 | 3306157 | D004181:Directories as Topic; D012953:Societies, Dental; D013714:Tennessee | D016435:Directory | [] | false | eng | J Tenn Dent Assoc | 7503125 | 0040-3385 | United States | [] | "2024-08-13T08:46:10.412142Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||||
Comparative evaluation of some enzymic digestion procedures in the release of basic drugs from tissue. | 11(4) | 164-7 | The relative efficiency of four enzymic-digestion procedures in the release of eight basic drugs from tissue has been studied. Enzymes employed include: subtilisin Carlsberg, trypsin, papain, and neutrase. The results obtained on recovery show that papain digestion gives highest recovery for most of the drugs studied. Papain is suggested as the enzyme of choice. The application of neutrase, a neutral proteinase from B. subtilis, is reported for the first time. | Journal of analytical toxicology | [
{
"affiliation": "",
"forename": "V",
"identifier": "",
"initials": "V",
"lastname": "Shankar"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Damodaran"
},
{
"affiliation": "",
"forename": "P C",
"identifier": "",
"initials": "PC",
"lastname": "Sekharan"
}
] | 1987 | 3306151 | D000818:Animals; D010450:Endopeptidases / Q000494:pharmacology; D015260:Neprilysin; D010206:Papain / Q000494:pharmacology; D004364:Pharmaceutical Preparations / Q000302:isolation & purification*; D012756:Sheep; D013381:Subtilisins / Q000494:pharmacology; D014357:Trypsin / Q000032:analysis | D003160:Comparative Study; D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D004364:Pharmaceutical Preparations; D010450:Endopeptidases; D013381:Subtilisins; D014357:Trypsin; D010206:Papain; D015260:Neprilysin | 10.1093/jat/11.4.164 | [] | false | eng | J Anal Toxicol | 7705085 | 0146-4760 | England | [] | "2024-08-13T08:46:10.412982Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Triple lumen venous access for pediatric bone marrow transplantation candidates. | 36(1) | 55-7 | Multiple routes of vascular access are required in children undergoing bone marrow transplantation to facilitate total parenteral nutrition (TPN); blood withdrawal; and administration of blood products, antibiotics, fluids, and immunosuppressive drugs. Placement of multiple catheters frequently requires multiple venotomies in separate vessels. We have found that both a Broviac catheter and pediatric dual-lumen Raaf catheter can be placed through separate venotomies in the external jugular vein, which provides sufficient routes of vascular access without complications. This technique places only one vessel at risk while minimizing the chance for infection by utilizing two exit sites. We consider this to be the procedure of choice in young patients requiring multiple routes of vascular access. | Journal of surgical oncology | [
{
"affiliation": "",
"forename": "J L",
"identifier": "",
"initials": "JL",
"lastname": "Weese"
},
{
"affiliation": "",
"forename": "M E",
"identifier": "",
"initials": "ME",
"lastname": "Trigg"
}
] | 1987-09 | 3306158 | D016026:Bone Marrow Transplantation; D002404:Catheterization / Q000295:instrumentation / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007601:Jugular Veins | D016428:Journal Article | 10.1002/jso.2930360113 | [] | false | eng | J Surg Oncol | 0222643 | 0022-4790 | United States | [] | "2024-08-13T08:46:10.414803Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Adjuvant chemotherapy in high-risk malignant melanoma. | 36(1) | 64-7 | Fifty-nine patients with regional or hematogenous recurrence of malignant melanoma following resection of all the gross tumor were randomized to observation or chemotherapy. The chemotherapy consisted of BCNU 80 mg/M2 I.V. every 4 weeks, actinomycin-D 0.01 mg/kg and vincristine 1.0 mg/M2 I.V. every 2 weeks, for a total of 6 months. The chemotherapy protocol was tolerated well without appreciable objective side effects. At a median follow-up period of 11.5 months, the disease-free survival time for the chemotherapy treated group is significantly longer than for the control group (P = 0.01). The estimated median disease-free survival time is 4 months in the surgical control group and 9 months in the chemotherapy group. At present, the proportion of patients remaining disease-free is 43% for the surgical control and 55% for the chemotherapy treated group. More patients and follow-up are needed, but this preliminary report suggests that nitrosourea-based protocols need to be evaluated further as adjuvant treatment of malignant melanoma. | Journal of surgical oncology | [
{
"affiliation": "",
"forename": "C P",
"identifier": "",
"initials": "CP",
"lastname": "Karakousis"
},
{
"affiliation": "",
"forename": "L J",
"identifier": "",
"initials": "LJ",
"lastname": "Emrich"
}
] | 1987-09 | 3306159 | D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002330:Carmustine / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003609:Dactinomycin / Q000008:administration & dosage; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D009362:Neoplasm Metastasis; D011446:Prospective Studies; D011897:Random Allocation; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D014750:Vincristine / Q000008:administration & dosage | D016430:Clinical Trial; D003160:Comparative Study; D016428:Journal Article; D016449:Randomized Controlled Trial | D003609:Dactinomycin; D014750:Vincristine; D002330:Carmustine | 10.1002/jso.2930360115 | [] | false | eng | J Surg Oncol | 0222643 | 0022-4790 | United States | [] | "2024-08-13T08:46:10.416087Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
A model for the control of testosterone secretion. | 123(2) | 239-50 | We produce here a model to explain the control of testosterone secretion. In this model the hypothalamic secretion of the hormone LHRH (luteinizing hormone releasing hormone) is controlled by a combination of local testosterone concentration and of the local concentration of the pituitary hormone LH (luteinizing hormone). Since LHRH stimulates the release of LH, and LH in turn stimulates the release of testosterone, the three hormones constitute a three-component "feedback" network. We show how this model is able to account for the pulsatility of the release of these three hormones. Furthermore, the model is consistent with results obtained from a wide range of experimental manipulations of the system. For example, it accounts for the changes observed in hormone release patterns after castration. In particular, it follows that no "neural clock", or "neural pulse-generator", is required to force the system into pulsatile behaviour. | Journal of theoretical biology | [
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Cartwright"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Husain"
}
] | 1986-11-21 | 3306160 | D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D010902:Pituitary Gland / Q000378:metabolism; D013737:Testis / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism* | D016428:Journal Article | D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone | 10.1016/s0022-5193(86)80158-8 | [] | false | eng | J Theor Biol | 0376342 | 0022-5193 | England | [] | "2024-08-13T08:46:10.417192Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Probing into the mechanism of action, metabolism and toxicity of gossypol by studying its (+)- and (-)-stereoisomers. | 20(1) | 65-78 | The chemistry of gossypol is very relevant to its unique actions. The two aldehyde groups can easily bind to proteins via aldehyde-amino group linkage. Gossypolone, the in vivo oxidation product of gossypol, may form a redox system with its corresponding hemiquinone, leading to free radical generation. There are marked differences in the disposition and metabolism between (+)- and (-)-gossypol. The elimination half life of (+)-gossypol was much longer than that of (-)-gossypol. The higher rate of elimination of (-)-gossypol may be due to its lower rate of binding to tissue proteins, since the Vd of (-)-gossypol was much smaller than that of the (+)-isomer. A single intratesticular injection of 200 micrograms of (-)-gossypol caused a 70.4% decrease of the sperm count along with marked atrophy of the testes. However, neither a significant decrease in sperm count nor atrophy of the testes was observed after a similar injection of (+)-gossypol, suggesting that there is a strict stereochemical requirement for the interaction between gossypol and the testicular target molecules. Racemic gossypol stimulated superoxide free-radical formation when incubated with either rat liver or kidney microsomes, but not with those of the heart or testes. Pretreatment with phenobarbital potentiated this effect in liver microsomes, while incubation with metyrapone decreased in renal microsomes. Both (+)- and (-)-gossypol exhibited similar potencies in renal or hepatic microsomes in vitro. At 100 mg/kg, both (+)- and (-)-gossypol were able to cause increases in SGPT in rats 12 and 24 h following the administration. The equipotency between the two isomers in causing toxic effects to some of the somatic tissues and the stereo-selectivity of (-)-gossypol to induce antispermatogenic effects indicate that gossypol may actually exhibit two categories of cytotoxic effects to different organs and tissues. This suggests that one may be able to eliminate one effect while keeping the other. | Journal of ethnopharmacology | [
{
"affiliation": "",
"forename": "Y W",
"identifier": "",
"initials": "YW",
"lastname": "Yu"
}
] | 1987-06 | 3306161 | D000818:Animals; D006072:Gossypol / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008253:Macaca mulatta; D008297:Male; D051381:Rats; D013237:Stereoisomerism | D016428:Journal Article; D016454:Review | D006072:Gossypol | 10.1016/0378-8741(87)90120-6 | [] | false | eng | J Ethnopharmacol | 7903310 | 0378-8741 | Ireland | [] | "2024-08-13T08:46:10.417950Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Histologic assessment of bronchial anastomotic healing in canine lung transplantation. | 94(3) | 323-30 | Postoperative wound healing of the bronchial anastomosis was studied in dogs with autotransplantation (20 dogs, 7 days to 6 years postoperatively) and allotransplantation (62 dogs, 5 to 174 days postoperatively) of the left lung. In the group undergoing lung allotransplantation, the relationship among three histologic parameters was studied: the grade of lung allograft rejection, the degree of changes in the epithelium, and submucous lymphocyte infiltration along the donor bronchus within approximately a 0.5 cm area distal to the anastomosis. In lung autotransplantation, mucosal continuity began to be observed 1 week postoperatively. Mucosal continuity and apparent collagen formation on any bronchial contiguous site were demonstrated in most animals studied more than 3 weeks postoperatively. Bronchial anastomotic healing tended to be slower in lung allotransplantation than in autotransplantation, although a mucosal continuity at the anastomosis was sporadically observed in immunosuppressed dogs surviving more than 3 weeks postoperatively with a lung allograft. There were significant rank correlations among the three histologic parameters, which showed that lung allograft rejection is closely connected with wound healing of the bronchial anastomosis in lung allotransplantation. Meticulous mucosal approximation is most necessary during bronchial anastomotic procedures. Establishment of an exact method for early monitoring of lung allograft rejection is absolutely necessary for lung allotransplantation. | The Journal of thoracic and cardiovascular surgery | [
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Fujimura"
},
{
"affiliation": "",
"forename": "T",
"identifier": "",
"initials": "T",
"lastname": "Kondo"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Handa"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Yamauchi"
},
{
"affiliation": "",
"forename": "T",
"identifier": "",
"initials": "T",
"lastname": "Okabe"
},
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Saito"
},
{
"affiliation": "",
"forename": "T",
"identifier": "",
"initials": "T",
"lastname": "Ichinose"
},
{
"affiliation": "",
"forename": "Y",
"identifier": "",
"initials": "Y",
"lastname": "Shiraishi"
},
{
"affiliation": "",
"forename": "T",
"identifier": "",
"initials": "T",
"lastname": "Nakada"
}
] | 1987-09 | 3306162 | D000818:Animals; D001980:Bronchi / Q000502:physiology / Q000601:surgery*; D004285:Dogs; D006084:Graft Rejection; D007165:Immunosuppression Therapy; D016040:Lung Transplantation; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014945:Wound Healing | D003160:Comparative Study; D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | [] | false | eng | J Thorac Cardiovasc Surg | 0376343 | 0022-5223 | United States | [] | "2024-08-13T08:46:10.419159Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Predictors, prevention, and long-term prognosis of atrial fibrillation after coronary artery bypass graft operations. | 94(3) | 331-5 | Multiple trials have suggested the use of digoxin, digoxin and propranolol, or timolol to prevent atrial fibrillation after coronary artery bypass grafting. No trial has evaluated the efficacy of digoxin verus propranolol. Furthermore, the predictors of postoperative atrial fibrillation and the long-term consequence of atrial fibrillation that reverts to sinus rhythm have not been established. One hundred fifty patients were randomized to receive no drug, propranolol (20 mg every 6 hours), or digoxin (0.5 mg followed by 0.25 mg daily). Twenty-seven patients were excluded from data analysis. In the remaining 123 patients, no preoperative parameter (age, sex, diabetes, hypertension, smoking, electrocardiographic p wave morphology, or preoperative digoxin or propranolol therapy), intraoperative parameter (bypass time, aortic cross-clamp time, or number of vessels bypassed), or postoperative parameter (peak creatinine kinase, congestive heart failure, or pericarditis) by univariate or multivariate analysis predicted patients at risk for atrial fibrillation. Sustained atrial fibrillation developed in 37.5% of control and 32.6% of digoxin-treated patients. Only 16.2% of propranolol-treated patients had sustained atrial fibrillation (p less than 0.03). There were no in-hospital complications in those patients with atrial fibrillation. After 26 +/- 7 months follow-up, those patients with postoperative atrial fibrillation had no increased incidence of angina, cerebral vascular accident, myocardial infarction, or sudden death. Therefore, in this select population, propranolol prophylaxis is effective but discretionary. | The Journal of thoracic and cardiovascular surgery | [
{
"affiliation": "",
"forename": "D A",
"identifier": "",
"initials": "DA",
"lastname": "Rubin"
},
{
"affiliation": "",
"forename": "K E",
"identifier": "",
"initials": "KE",
"lastname": "Nieminski"
},
{
"affiliation": "",
"forename": "G E",
"identifier": "",
"initials": "GE",
"lastname": "Reed"
},
{
"affiliation": "",
"forename": "M V",
"identifier": "",
"initials": "MV",
"lastname": "Herman"
}
] | 1987-09 | 3306163 | D001281:Atrial Fibrillation / Q000209:etiology / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D004077:Digoxin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011433:Propranolol / Q000627:therapeutic use; D011897:Random Allocation; D012306:Risk; D013997:Time Factors | D016430:Clinical Trial; D003160:Comparative Study; D016428:Journal Article; D016449:Randomized Controlled Trial; D013485:Research Support, Non-U.S. Gov't | D004077:Digoxin; D011433:Propranolol | [] | false | eng | J Thorac Cardiovasc Surg | 0376343 | 0022-5223 | United States | [] | "2024-08-13T08:46:10.421255Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
A surgical preparative technique for coronary bypass grafts of human saphenous vein which preserves medial and endothelial functional integrity. | 94(3) | 393-8 | Measurements of adenosine triphosphate concentration and adenosine triphosphate/diphosphate ratio provided quantitative markers for medial integrity and stimulated (vortex-mixing) prostacyclin production for endothelial function. Freshly isolated vein had an adenosine triphosphate concentration of 470 +/- 60 nmol X gm-1 wet weight and an adenosine triphosphate/diphosphate ratio of 2.50 +/- 0.13; it produced prostacyclin at a rate of 9.3 +/- 1.0 pg X min-1 X mg-1 wet weight. Vein subjected to dissection, proximal anastomosis, and distention with the patient's own arterial pressure had an adenosine triphosphate concentration of 490 +/- 70 nmol X gm-1 wet weight and an adenosine triphosphate/diphosphate ratio of 2.29 +/- 0.13; it produced prostacyclin at a rate of 10.4 +/- 2.2 pg X min-1 X mg-1 wet weight. All values were indistinguishable from those in freshly isolated vein. In vein subjected to dissection, distention at less than 300 mm Hg with patient's heparinized blood, and distal anastomosis, adenosine triphosphate concentration, adenosine triphosphate/diphosphate ratio, and prostacyclin production (5.5 +/- 0.6 pg X min-1 X mg-1 wet weight) were all significantly (p less than 0.001) reduced. These results demonstrated that surgical preparation by first proximal anastomosis preserved both medial and endothelial function. | The Journal of thoracic and cardiovascular surgery | [
{
"affiliation": "",
"forename": "G D",
"identifier": "",
"initials": "GD",
"lastname": "Angelini"
},
{
"affiliation": "",
"forename": "I M",
"identifier": "",
"initials": "IM",
"lastname": "Breckenridge"
},
{
"affiliation": "",
"forename": "H M",
"identifier": "",
"initials": "HM",
"lastname": "Williams"
},
{
"affiliation": "",
"forename": "A C",
"identifier": "",
"initials": "AC",
"lastname": "Newby"
}
] | 1987-09 | 3306164 | D000244:Adenosine Diphosphate / Q000032:analysis; D000255:Adenosine Triphosphate / Q000032:analysis; D001807:Blood Vessel Prosthesis; D001026:Coronary Artery Bypass / Q000379:methods*; D004727:Endothelium / Q000502:physiology; D011464:Epoprostenol / Q000096:biosynthesis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012501:Saphenous Vein / Q000502:physiology / Q000601:surgery* | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D011464:Epoprostenol | [] | false | eng | J Thorac Cardiovasc Surg | 0376343 | 0022-5223 | United States | [] | "2024-08-13T08:46:10.422290Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Mucoepidermoid bronchial adenoma in a 6-year-old girl: a case report and review of the literature. | 94(3) | 452-4 | A rare case of a mucoepidermoid bronchial adenoma discovered in a 6-year-old girl with recurrent pneumonia is presented. A review of the literature suggests that less than 15 cases in the pediatric age group have been reported. Although primary lung carcinomas are rare in children, this case illustrates that recurrent lobar pneumonia in children should be aggressively investigated and that the proper therapy is conservative surgical resection. | The Journal of thoracic and cardiovascular surgery | [
{
"affiliation": "",
"forename": "R L",
"identifier": "",
"initials": "RL",
"lastname": "Archer"
},
{
"affiliation": "",
"forename": "S E",
"identifier": "",
"initials": "SE",
"lastname": "Grogg"
},
{
"affiliation": "",
"forename": "S P",
"identifier": "",
"initials": "SP",
"lastname": "Sanders"
}
] | 1987-09 | 3306166 | D000236:Adenoma / Q000601:surgery*; D002283:Carcinoma, Bronchogenic / Q000601:surgery*; D002648:Child; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery* | D002363:Case Reports; D016428:Journal Article; D016454:Review | [] | false | eng | J Thorac Cardiovasc Surg | 0376343 | 0022-5223 | United States | [] | "2024-08-13T08:46:10.423114Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Migration of temporary epicardial pacer wire fragment retained after a cardiac operation. | 94(3) | 446-7 | Reported complications of retained temporary epicardial pacer wires after cardiac operations have been confined to infections. We report the migration of the retained fragment into the free peritoneal cavity after 6 years of stability in the precordium. | The Journal of thoracic and cardiovascular surgery | [
{
"affiliation": "",
"forename": "F L",
"identifier": "",
"initials": "FL",
"lastname": "Korompai"
},
{
"affiliation": "",
"forename": "R H",
"identifier": "",
"initials": "RH",
"lastname": "Hayward"
},
{
"affiliation": "",
"forename": "W L",
"identifier": "",
"initials": "WL",
"lastname": "Knight"
}
] | 1987-09 | 3306165 | D000328:Adult; D005547:Foreign Bodies / Q000000981:diagnostic imaging*; D005548:Foreign-Body Migration / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial / Q000009:adverse effects*; D011859:Radiography | D002363:Case Reports; D016428:Journal Article | [] | false | eng | J Thorac Cardiovasc Surg | 0376343 | 0022-5223 | United States | [] | "2024-08-13T08:46:10.424123Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Balloon-like platelets in myelodysplastic syndromes--a feature of dysmegakaryopoiesis? | 11(8) | 747-52 | Large bizarre platelets are a frequent finding in the peripheral blood of the myelodysplastic syndrome (MDS). In this study we describe a distinct subpopulation of platelets in MDS which by phase contrast microscopic examination seems to have a balloon-shaped bulge of the cell membrane. Increased numbers of these atypical platelets were found in 24 of 27 MDS patients (89%). Only 3 patients, all with ringsideroblastic anemia, had normal platelet morphology. The number of atypical platelets were negatively correlated (r = 0.44; p = 0.021) to the peripheral platelet counts in MDS. Among 48 patients with acute leukemia, chronic lymphoproliferative or chronic myeloproliferative disorders, 13 (27%) had atypical platelets. Here, but not in the MDS group, atypical platelets seemed to be associated with recent chemotherapy. In a group of patients with benign hematological disorders abnormal platelet morphology was seen only occasionally. The described atypical platelets most likely reflect maturation disturbances of the megakaryopoiesis. An increased value (greater than 1%) in a cytopenic patient would suggest a diagnosis of MDS, unless associated with recent cytotoxic therapy. | Leukemia research | [
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Widell"
},
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Hast"
}
] | 1987 | 3306168 | D000970:Antineoplastic Agents / Q000627:therapeutic use; D001792:Blood Platelets / Q000145:classification / Q000473:pathology*; D006402:Hematologic Diseases / Q000097:blood; D006410:Hematopoiesis; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000188:drug therapy; D008533:Megakaryocytes / Q000473:pathology*; D008858:Microscopy, Phase-Contrast; D009190:Myelodysplastic Syndromes / Q000097:blood* | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D000970:Antineoplastic Agents | 10.1016/0145-2126(87)90012-9 | [] | false | eng | Leuk Res | 7706787 | 0145-2126 | England | [] | "2024-08-13T08:46:10.424917Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Chromosome studies of hematopoietic colonies for distinct diagnosis of megakaryoblastic crisis of chronic myelogenous leukemia: a case report. | 11(8) | 711-8 | Chromosome studies of cells from megakaryocytic colonies (CFU-Meg) as evidenced by a megakaryocyte-specific monoclonal antibody, TP80, from a patient with chronic myelogenous leukemia (CML) in the blast crisis (BC) revealed the same aberrant karyotype, 52,XY,+9,+9,+18,+19,+21,+22,t(9;22)(q34;q11),t(9;22), as that having newly appeared in the peripheral blood. Cells from erythroid bursts (BFU-E) showed only the standard 46,XY,t(9;22) karyotype, and cells from granulocyte/macrophage colonies (CFU-GM) had either of these karyotypes. These results demonstrated that the whole megakaryocytic line and part of the granulocyte/macrophage line had been involved in the BC while the erythroid line totally belonged to the original clone. Chromosome analysis coupled with immunophenotyping of hemopoietic colonies was useful for a definite diagnosis of megakaryoblastic crisis of CML in this patient. | Leukemia research | [
{
"affiliation": "",
"forename": "Y",
"identifier": "",
"initials": "Y",
"lastname": "Shiga"
},
{
"affiliation": "",
"forename": "H",
"identifier": "",
"initials": "H",
"lastname": "Kimura"
},
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Abe"
},
{
"affiliation": "",
"forename": "T",
"identifier": "",
"initials": "T",
"lastname": "Sato"
},
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Matsuda"
},
{
"affiliation": "",
"forename": "T",
"identifier": "",
"initials": "T",
"lastname": "Uchida"
},
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Kariyone"
},
{
"affiliation": "",
"forename": "N",
"identifier": "",
"initials": "N",
"lastname": "Maseki"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Sakurai"
}
] | 1987 | 3306167 | D000328:Adult; D002875:Chromosomes; D005455:Fluorescent Antibody Technique; D006412:Hematopoietic Stem Cells / Q000473:pathology / Q000502:physiology*; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008297:Male; D010641:Phenotype | D002363:Case Reports; D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | 10.1016/0145-2126(87)90007-5 | [] | false | eng | Leuk Res | 7706787 | 0145-2126 | England | [] | "2024-08-13T08:46:10.427284Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
A two-step t(4;der(15)) t(15;17) complex translocation in an acute promyelocytic leukaemia and review of the literature. | 11(8) | 761-5 | Leukemia research | [
{
"affiliation": "",
"forename": "J L",
"identifier": "",
"initials": "JL",
"lastname": "Huret"
},
{
"affiliation": "",
"forename": "D",
"identifier": "",
"initials": "D",
"lastname": "Couet"
},
{
"affiliation": "",
"forename": "F",
"identifier": "",
"initials": "F",
"lastname": "Guilhot"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Brizard"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Tanzer"
}
] | 1987 | 3306169 | D000368:Aged; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic | D002363:Case Reports; D016428:Journal Article; D016454:Review | 10.1016/0145-2126(87)90014-2 | [] | false | eng | Leuk Res | 7706787 | 0145-2126 | England | [] | "2024-08-13T08:46:10.428102Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Feasibility of electrical recordings from unconnected vertebrate CNS neurons cultured in a three-dimensional extracellular matrix. | 20(3) | 203-10 | Single, i.e. unconnected spinal or cerebral neurons from chick embryos rapidly regenerate morphologically identifiable axons and dendrites when cultured in a three-dimensional (3-D) extracellular matrix (ECM) consisting of a hydrated native collagen lattice. We now show that it is possible to study the intrinsic electrophysiological properties of such neurons as early as 2 days in culture. Cells were plated at 10(5) cells/dish using Medium 199 containing 10% fetal calf serum but no other supplements or antibiotics-antimycotics. A patch-clamp/whole-cell voltage clamp system was used to record single-channel currents from cell-attached patches, transmembrane potentials during the injection of rectangular currents, and whole-cell currents during voltage clamp. After 2-4 days in culture, isolated cerebral and spinal neurons exhibited single-channel currents. Within 7 days, rectangular currents injected through the recording electrode evoked action potentials. These results demonstrate that unconnected CNS neurons quickly display at least some properties of excitability when cultured in a 3-D ECM. This culture system should facilitate investigation of intrinsic electrical properties of single CNS neurons, and how extrinsic factors including neurotransmitters, hormones, pharmacological agents and contacts with other cells influence electrical activity. | Journal of neuroscience methods | [
{
"affiliation": "",
"forename": "P W",
"identifier": "",
"initials": "PW",
"lastname": "Coates"
},
{
"affiliation": "",
"forename": "R D",
"identifier": "",
"initials": "RD",
"lastname": "Nathan"
}
] | 1987-07 | 3306170 | D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000502:physiology*; D002642:Chick Embryo; D003094:Collagen; D003584:Cytological Techniques; D004594:Electrophysiology; D005109:Extracellular Matrix / Q000502:physiology*; D009474:Neurons / Q000502:physiology* | D016428:Journal Article; D013487:Research Support, U.S. Gov't, P.H.S. | D003094:Collagen | 10.1016/0165-0270(87)90052-5 | [] | false | eng | J Neurosci Methods | 7905558 | 0165-0270 | Netherlands | [] | "2024-08-13T08:46:10.428915Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
An in vitro slice preparation of the cat lateral geniculate nucleus. | 20(3) | 211-9 | A slice preparation of the cat thalamus containing the lateral geniculate nucleus and the terminal portion of the optic tract is described. Ultrastructurally the slices remain relatively normal for only a short time after cutting. Indeed most cellular elements deteriorate quickly with time but patches of relatively intact tissue were still present even 10 h after cutting and maintenance in a storage bath. However, for 4-5 h after cutting long-lasting intracellular recordings of high quality and stability were obtained, and intrasomatic injection of horseradish peroxidase used for the morphological identification of recorded neurones as X or Y cells. | Journal of neuroscience methods | [
{
"affiliation": "",
"forename": "V",
"identifier": "",
"initials": "V",
"lastname": "Crunelli"
},
{
"affiliation": "",
"forename": "N",
"identifier": "",
"initials": "N",
"lastname": "Leresche"
},
{
"affiliation": "",
"forename": "J W",
"identifier": "",
"initials": "JW",
"lastname": "Hynd"
},
{
"affiliation": "",
"forename": "N M",
"identifier": "",
"initials": "NM",
"lastname": "Patel"
},
{
"affiliation": "",
"forename": "J G",
"identifier": "",
"initials": "JG",
"lastname": "Parnavelas"
}
] | 1987-07 | 3306171 | D000818:Animals; D002415:Cats; D004594:Electrophysiology; D005829:Geniculate Bodies / Q000502:physiology* / Q000648:ultrastructure; D006652:Histological Techniques; D006735:Horseradish Peroxidase; D066298:In Vitro Techniques; D008839:Microelectrodes; D008854:Microscopy, Electron; D013569:Synapses / Q000648:ultrastructure | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | D006735:Horseradish Peroxidase | 10.1016/0165-0270(87)90053-7 | [] | false | eng | J Neurosci Methods | 7905558 | 0165-0270 | Netherlands | [] | "2024-08-13T08:46:10.430085Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Non-pharmacological effects of the use of microelectrophoresis and pressure ejection of drugs in combination. | 20(3) | 221-7 | Pressure ejection of physiological saline from multibarrel micropipette assemblies has been shown to selectively reduce responses of rat spinal cord neurones to electrophoretic ejection of kainate, N-methyl-aspartate and 4-methyl-homoibotenate, but not of quisqualate or L-glutamate. Reduction of response to an excitatory amino acid therefore appears to be correlated with the absence of an active transport system for that amino acid. | Journal of neuroscience methods | [
{
"affiliation": "",
"forename": "S N",
"identifier": "",
"initials": "SN",
"lastname": "Davies"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Church"
},
{
"affiliation": "",
"forename": "D",
"identifier": "",
"initials": "D",
"lastname": "Lodge"
}
] | 1987-07 | 3306172 | D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D004586:Electrophoresis / Q000379:methods*; D007051:Ibotenic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology; D008839:Microelectrodes; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009543:Nifedipine / Q000494:pharmacology; D010069:Oxadiazoles / Q000494:pharmacology; D016318:Quisqualic Acid; D051381:Rats; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology* | D016428:Journal Article | D000596:Amino Acids; D010069:Oxadiazoles; D007051:Ibotenic Acid; D001224:Aspartic Acid; D016202:N-Methylaspartate; C023364:homoibotenic acid; D016318:Quisqualic Acid; D009543:Nifedipine; D007608:Kainic Acid | 10.1016/0165-0270(87)90054-9 | [] | false | eng | J Neurosci Methods | 7905558 | 0165-0270 | Netherlands | [] | "2024-08-13T08:46:10.431181Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
A method for automatic classification of large and small myelinated fibre populations in peripheral nerves. | 20(3) | 237-48 | The statistical analysis of morphometric data collected from biopsies of human superficial peroneal nerve is complicated by the heterogeneity of the population of myelinated fibres. In order to make separate statistical analyses of the subpopulations of large and small fibres we have developed a computer program (written in PASCAL) for their automatic separation. The method is based on a dynamic centres clustering algorithm and was applied to the multifactorial space defined by the principal component analysis of the morphometric variables: axonal diameter, myelin sheath thickness, circularity index and g-ratio. The classification technique was applied to measurements obtained from 5 control nerves, and to simulated data, and in each case it gave consistent Gaussian subpopulations with no need for the introduction of supplementary variables. | Journal of neuroscience methods | [
{
"affiliation": "",
"forename": "Y",
"identifier": "",
"initials": "Y",
"lastname": "Usson"
},
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Torch"
},
{
"affiliation": "",
"forename": "G",
"identifier": "",
"initials": "G",
"lastname": "Drouet d'Aubigny"
}
] | 1987-07 | 3306173 | D000465:Algorithms; D003584:Cytological Techniques; D006801:Humans; D009413:Nerve Fibers, Myelinated / Q000166:cytology*; D009462:Neurology / Q000379:methods*; D009474:Neurons / Q000145:classification*; D010543:Peroneal Nerve / Q000166:cytology*; D012984:Software | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | 10.1016/0165-0270(87)90056-2 | [] | false | eng | J Neurosci Methods | 7905558 | 0165-0270 | Netherlands | [] | "2024-08-13T08:46:10.432069Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
A simple device for the computer quantification of depth measurements in thick light microscope sections. | 20(3) | 249-60 | The use of computerized techniques to characterize quantitatively the anatomy of individual neurons has been increasing. One difficulty has been the quantification of the z-axis or depth measurements within thick light microscopic sections. In the present report we describe a simple device which employs an incremental optical encoder to transduce the movements of the focusing knob of the microscope so that depth information can be recorded directly by a computer. A resolution of 0.13 micron over a range of approximately 8.5 cm is achieved. The mechanical interface to the microscope is simple and applicable to a wide variety of microscopes. Interfacing circuits which allow the optical encoder to be used with an IBM-PC compatible computer are presented and described. The accuracy of the depth measurements is limited only by the mechanical tolerances of the focusing mechanism and by the optics of the microscope. | Journal of neuroscience methods | [
{
"affiliation": "",
"forename": "G T",
"identifier": "",
"initials": "GT",
"lastname": "Gdowski"
},
{
"affiliation": "",
"forename": "W D",
"identifier": "",
"initials": "WD",
"lastname": "Eldred"
},
{
"affiliation": "",
"forename": "H F",
"identifier": "",
"initials": "HF",
"lastname": "Voigt"
}
] | 1987-07 | 3306174 | D004559:Electric Wiring; D004867:Equipment Design; D006652:Histological Techniques; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation* / Q000592:standards | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't; D013486:Research Support, U.S. Gov't, Non-P.H.S.; D013487:Research Support, U.S. Gov't, P.H.S. | 10.1016/0165-0270(87)90057-4 | [] | false | eng | J Neurosci Methods | 7905558 | 0165-0270 | Netherlands | [
{
"agency": "NEI NIH HHS",
"country": "United States",
"grant_acronym": "EY",
"grant_id": "EY 04785-05"
},
{
"agency": "NINDS NIH HHS",
"country": "United States",
"grant_acronym": "NS",
"grant_id": "NS 18386-03"
}
] | "2024-08-13T08:46:10.433933Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Tumor necrosis factor induced stimulation of granulopoiesis and radioprotection. | 6(3) | 179-86 | Human recombinant tumor necrosis factor, TNF, was used to assess its ability to stimulate granulopoiesis and to protect mice against lethal irradiation, effects known to be inducable with TNF-rich postendotoxin serum from BCG infected mice (BCG/ET serum). Although the endotoxin contamination of this TNF preparation is extremely low its effects were compared in endotoxin low responder C3H/HeJ mice and susceptible NMRI mice. TNF is a potent inducer of serum colony stimulating activity, CSA, in both mouse strains. In peripheral blood a marked granulocytosis with a concomitant decrease in lymphocytes and monocytopenia occurs at 2 hours after injection of TNF. Moreover, TNF induces an increase in the number of splenic myelopoietic committed stem cells (GM-CFC, granulocyte-macrophage colony forming cells) determined five days after injection. The lethality rate, registered over 30 days after exposure to 660 cGy whole body X-irradiation is reduced to 40% in C3H/HeJ mice as compared to 75% in control animals. The reduction in lethality is observed both, when TNF was injected 24 hours before or after irradiation. In vitro, TNF significantly increases the number of colonies in the presence of CSA in bone marrow cultures. TNF per se does not effect colony growth. The studies reported here demonstrate that TNF is a myelopoiesis stimulating factor in mice which may be related to the reduction in lethality following whole body irradiation. | Lymphokine research | [
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Urbaschek"
},
{
"affiliation": "",
"forename": "D N",
"identifier": "",
"initials": "DN",
"lastname": "Männel"
},
{
"affiliation": "",
"forename": "B",
"identifier": "",
"initials": "B",
"lastname": "Urbaschek"
}
] | 1987 | 3306175 | D000818:Animals; D005260:Female; D006023:Glycoproteins / Q000494:pharmacology*; D006098:Granulocytes / Q000166:cytology* / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D011837:Radiation-Protective Agents; D011994:Recombinant Proteins / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha; D014916:Whole-Body Irradiation | D016428:Journal Article | D006023:Glycoproteins; D011837:Radiation-Protective Agents; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha | [] | false | eng | Lymphokine Res | 8308208 | 0277-6766 | United States | [] | "2024-08-13T08:46:10.434834Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Whole-body exposure to ultraviolet radiation results in increased serum interleukin-1 activity in humans. | 6(3) | 187-93 | Human volunteers given one minimal erythemal dose of ultraviolet radiation (UVR) from fluorescent sunlamps developed increased serum interleukin-1 (IL-1) activity as assessed by the thymocyte co-stimulator assay. This activity peaked 1 to 4 hours after exposure and returned to baseline by 8 hours after exposure. Six to 12 months later, some of the same subjects had blood samples taken over the same time course but without exposure to UVR; no elevation in serum IL-1 was observed. In addition to lymphocyte activating activity, IL-1 has been reported to have endogenous pyrogen activity, chemotactic activity for neutrophils and mononuclear cells, and inflammatory activity when injected subcutaneously in vivo. Elevations in serum IL-1 activity after exposure to ultraviolet radiation may account for some of the manifestations of the sunburn response. | Lymphokine research | [
{
"affiliation": "",
"forename": "R D",
"identifier": "",
"initials": "RD",
"lastname": "Granstein"
},
{
"affiliation": "",
"forename": "D N",
"identifier": "",
"initials": "DN",
"lastname": "Sauder"
}
] | 1987 | 3306176 | D000328:Adult; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007375:Interleukin-1 / Q000097:blood / Q000528:radiation effects*; D008297:Male; D013997:Time Factors; D014466:Ultraviolet Rays; D014916:Whole-Body Irradiation | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't; D013487:Research Support, U.S. Gov't, P.H.S. | D007375:Interleukin-1 | [] | false | eng | Lymphokine Res | 8308208 | 0277-6766 | United States | [
{
"agency": "NIADDK NIH HHS",
"country": "United States",
"grant_acronym": "AM",
"grant_id": "AM01425-02"
},
{
"agency": "NIA NIH HHS",
"country": "United States",
"grant_acronym": "AG",
"grant_id": "R01 AG04956"
}
] | "2024-08-13T08:46:10.435886Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Growth factor, viruses, and oncogenes in human lymphoid neoplasia. | 6(3) | 245-65 | Lymphokine research | [
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Sharma"
},
{
"affiliation": "",
"forename": "S R",
"identifier": "",
"initials": "SR",
"lastname": "Mehta"
},
{
"affiliation": "",
"forename": "R J",
"identifier": "",
"initials": "RJ",
"lastname": "Ford"
}
] | 1987 | 3306177 | D002471:Cell Transformation, Neoplastic; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D008223:Lymphoma / Q000235:genetics / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D009857:Oncogenes; D012190:Retroviridae / Q000235:genetics | D016428:Journal Article; D013487:Research Support, U.S. Gov't, P.H.S.; D016454:Review | D006133:Growth Substances | [] | false | eng | Lymphokine Res | 8308208 | 0277-6766 | United States | [
{
"agency": "NCI NIH HHS",
"country": "United States",
"grant_acronym": "CA",
"grant_id": "CA16652"
},
{
"agency": "NCI NIH HHS",
"country": "United States",
"grant_acronym": "CA",
"grant_id": "CA31479"
},
{
"agency": "NCI NIH HHS",
"country": "United States",
"grant_acronym": "CA",
"grant_id": "CA39798"
}
] | "2024-08-13T08:46:10.436651Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Magnesium as a regulatory cation: criteria and evaluation. | 6(3) | 113-27 | Of the two major intracellular divalent cations, Ca2+ has been studied much more extensively than Mg2+ and is now well accepted as a major intracellular regulator. This review focuses instead on some recent advances in the understanding of the physiology and biochemistry of Mg2+. For purposes of discussion, four criteria have been developed that should be fulfilled if Mg2+ is to be accepted as an important intracellular regulatory cation: cellular processes must exist which are sensitive to free Mg2+ within the physiological concentration range; a (transport) mechanism(s) must exist which is capable of altering free Mg2+ concentration within a cell; if Mg2+ is compartmented within cells, any potentially regulated system or process and any change in intracellular free Mg2+ concentration must be shown to occur within the same compartment; and any change(s) in free Mg2+ concentration and any alteration(s) in a Mg2+-sensitive process must occur in a sequential manner. These criteria are largely but not completely met at the present time. Criteria 1 and probably 2 can be shown in at least some systems to be fully met. Criteria 3 and 4 are partially met but neither can be fully examined until methods for measuring intracellular free Mg2+ concentrations on an appropriate time scale are further developed. Thus, there exists strong but as yet incomplete evidence that Mg2+, like Ca2+, can play an active, regulatory role within cells. Finally, it is suggested that Ca2+ plays the specific role of the acute, transient regulatory element while Mg2+ plays the complementary role of a more long-term regulatory element which controls the set point or gain of a system or process. | Magnesium | [
{
"affiliation": "",
"forename": "R D",
"identifier": "",
"initials": "RD",
"lastname": "Grubbs"
},
{
"affiliation": "",
"forename": "M E",
"identifier": "",
"initials": "ME",
"lastname": "Maguire"
}
] | 1987 | 3306178 | D000818:Animals; D001692:Biological Transport; D001696:Biomechanical Phenomena; D002413:Cations, Divalent; D007425:Intracellular Membranes / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D009994:Osmolar Concentration; D013997:Time Factors | D016428:Journal Article; D016454:Review | D002413:Cations, Divalent; D008274:Magnesium | [] | false | eng | Magnesium | 8219687 | 0252-1156 | Switzerland | [] | "2024-08-13T08:46:10.437466Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Magnesium and pregnancy. | 6(3) | 128-35 | Human pregnancy is characterized by several cardiovascular changes, among them a 50% increase in cardiac output, a decrease in the systemic vascular resistance, a 40% blood volume expansion, a decrease in mean arterial blood pressure and a 10-15 beats/min increase in heart rate. It is possible that alterations in magnesium metabolism may be responsible for some of the physiological changes seen during pregnancy and in many diseases related to cardiovascular abnormalities. Magnesium (Mg2+) has been used extensively in obstetrics for the treatment of alterations of uterine contractility (premature labor) or increased neuronal and vascular smooth muscle activity (pre-eclampsia). This review focuses on some of the alterations seen in Mg2+ metabolism during pregnancy. In addition, some of the problems regarding Mg2+ metabolism and parenteral administration of Mg2+ in the treatment of pre-eclampsia and eclampsia are discussed. The use of Mg2+ during labor and as prophylaxis to prevent rupture of membranes and premature labor are also reviewed and discussed. | Magnesium | [
{
"affiliation": "",
"forename": "G J",
"identifier": "",
"initials": "GJ",
"lastname": "Valenzuela"
},
{
"affiliation": "",
"forename": "L A",
"identifier": "",
"initials": "LA",
"lastname": "Munson"
}
] | 1987 | 3306179 | D004461:Eclampsia / Q000188:drug therapy; D005260:Female; D005322:Fetal Membranes, Premature Rupture / Q000517:prevention & control; D006801:Humans; D007263:Infusions, Parenteral; D008274:Magnesium / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D011225:Pre-Eclampsia / Q000188:drug therapy; D011247:Pregnancy / Q000502:physiology*; D014590:Uterine Contraction / Q000187:drug effects | D016428:Journal Article; D016454:Review | D008274:Magnesium | [] | false | eng | Magnesium | 8219687 | 0252-1156 | Switzerland | [] | "2024-08-13T08:46:10.439407Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Graded exercise testing and training after renal transplantation: a preliminary study. | 62(9) | 773-7 | Aerobic exercise training has been used as part of the treatment for a variety of chronic disorders, most notably cardiovascular disease. In order to determine the feasibility and utility of regular exercise after renal transplantation, the responses of 10 patients to graded exercise testing were compared before training (T1), immediately after a program of supervised exercise training (T2), and a mean of 2.2 years after completion of the supervised program (T3). Supervised exercise sessions began a mean of 17 days postoperatively and continued for a mean of 5.5 weeks. Patients were encouraged to continue regular unsupervised exercise thereafter. All patients easily tolerated the supervised exercise sessions, which consisted of treadmill walking and cycle ergometry. Exercise capacity improved 90% between T1 and T2 and an additional 12% between T2 and T3. On the average, patients achieved a normal exercise capacity by 8 weeks after transplantation. Of the 10 patients, 7 had continued regular exercise training at T3. The observed increase in aerobic exercise capacity was probably related to improved renal function, an increased hemoglobin concentration, and the surgical healing process as well as the exercise training. We conclude that supervised exercise training for selected patients after renal transplantation is feasible and worthwhile. | Mayo Clinic proceedings | [
{
"affiliation": "",
"forename": "T D",
"identifier": "",
"initials": "TD",
"lastname": "Miller"
},
{
"affiliation": "",
"forename": "R W",
"identifier": "",
"initials": "RW",
"lastname": "Squires"
},
{
"affiliation": "",
"forename": "G T",
"identifier": "",
"initials": "GT",
"lastname": "Gau"
},
{
"affiliation": "",
"forename": "D M",
"identifier": "",
"initials": "DM",
"lastname": "Ilstrup"
},
{
"affiliation": "",
"forename": "P P",
"identifier": "",
"initials": "PP",
"lastname": "Frohnert"
},
{
"affiliation": "",
"forename": "S",
"identifier": "",
"initials": "S",
"lastname": "Sterioff"
}
] | 1987-09 | 3306180 | D000293:Adolescent; D000328:Adult; D005069:Evaluation Studies as Topic; D005080:Exercise Test / Q000379:methods; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000534:rehabilitation / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D013997:Time Factors | D016428:Journal Article | 10.1016/s0025-6196(12)62329-5 | [] | false | eng | Mayo Clin Proc | 0405543 | 0025-6196 | England | [] | "2024-08-13T08:46:10.440366Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
The penicillins. | 62(9) | 806-20 | The penicillin family of antibiotics is ever expanding and remains an important part of our antimicrobial armamentarium. These medications generally have bactericidal activity, excellent distribution throughout the body, low toxicity, and efficacy against infections due to susceptible organisms. The clinical introduction of aqueous penicillin G for treatment of streptococcal and staphylococcal infections was an important pharmacologic landmark. The emergence of penicillinase-producing staphylococci prompted the development of the penicillinase-resistant penicillins (methicillin, oxacillin, nafcillin, and others), in which the acyl side chain prevented disruption of the beta-lactamase ring. The aminopenicillins (ampicillin, amoxicillin, and others) were later developed because of the need for gram-negative antimicrobial activity. Their spectrum included Escherichia coli, Proteus mirabilis, Shigella, Salmonella, Listeria, and Haemophilus. The search for a penicillin with even further antimicrobial activity against the Enterobacteriaceae and Pseudomonas aeruginosa led to the development of the carboxypenicillins, ureidopenicillins, and piperazine penicillins. Recently, the combination of a beta-lactamase inhibitor (clavulanic acid or sulbactam) and an amino-penicillin or ticarcillin has resulted in further extension of their antibacterial spectra. The development of an ideal penicillin that is nonsensitizing, bioavailable, beta-lactamase-resistant, rapidly bactericidal, nontoxic, and inexpensive and that has high affinity to penicillin-binding proteins and no inoculum effect remains the goal. | Mayo Clinic proceedings | [
{
"affiliation": "",
"forename": "A J",
"identifier": "",
"initials": "AJ",
"lastname": "Wright"
},
{
"affiliation": "",
"forename": "C J",
"identifier": "",
"initials": "CJ",
"lastname": "Wilkowske"
}
] | 1987-09 | 3306181 | D001424:Bacterial Infections / Q000188:drug therapy; D004342:Drug Hypersensitivity / Q000209:etiology; D006801:Humans; D010406:Penicillins / Q000009:adverse effects / Q000627:therapeutic use* | D003160:Comparative Study; D016428:Journal Article; D016454:Review | D010406:Penicillins | 10.1016/s0025-6196(12)62335-0 | [] | false | eng | Mayo Clin Proc | 0405543 | 0025-6196 | England | [] | "2024-08-13T08:46:10.441169Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Monitoring of coagulation during liver transplantation--how much is enough? | 62(9) | 848-9 | Mayo Clinic proceedings | [
{
"affiliation": "",
"forename": "F A",
"identifier": "",
"initials": "FA",
"lastname": "Bontempo"
}
] | 1987-09 | 3306183 | D001779:Blood Coagulation Factors / Q000032:analysis*; D006801:Humans; D016031:Liver Transplantation | D016421:Editorial | D001779:Blood Coagulation Factors | 10.1016/s0025-6196(12)62340-4 | [] | false | eng | Mayo Clin Proc | 0405543 | 0025-6196 | England | [] | "2024-08-13T08:46:10.442130Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Cephalosporin, carbapenem, and monobactam antibiotics. | 62(9) | 821-34 | Cephalosporin and related antibiotics are highly effective bactericidal agents of relatively low toxicity. The spectrum of activity varies with the drug but is usually broad. The first-generation cephalosporins, and especially cefazolin, are most active against sensitive staphylococci and streptococci. Most second-generation (except cefoxitin) and third-generation cephalosporins show substantial activity against Haemophilus influenzae. All cephalosporins (except cefsulodin) are active against Klebsiella, Escherichia coli, and Proteus mirabilis, whereas only the third-generation agents have pronounced activity against the other Enterobacteriaceae. Imipenem (a carbapenem) is active against essentially all pathogenic organisms, but aztreonam (a monobactam) is active against only aerobic gram-negative bacilli. Advantages associated with some of the new cephalosporins are once-daily administration and high cerebrospinal fluid levels. With the development of new cephalosporins, however, new toxicities have become apparent, and superinfections and induction of resistance have become greater problems. The cephalosporins are among the most expensive antibiotics in use today; thus, use of these expensive agents must be justified by lower toxicity, greater efficacy, or both in comparison with drugs of more reasonable cost. | Mayo Clinic proceedings | [
{
"affiliation": "",
"forename": "R L",
"identifier": "",
"initials": "RL",
"lastname": "Thompson"
}
] | 1987-09 | 3306182 | D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002511:Cephalosporins / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D006801:Humans; D008997:Monobactams / Q000627:therapeutic use*; D013845:Thienamycins / Q000627:therapeutic use* | D003160:Comparative Study; D016428:Journal Article; D016454:Review | D002511:Cephalosporins; D008997:Monobactams; D013845:Thienamycins; C039536:panipenem | 10.1016/s0025-6196(12)62336-2 | [] | false | eng | Mayo Clin Proc | 0405543 | 0025-6196 | England | [] | "2024-08-13T08:46:10.442856Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Argentinian paleontologist contributes to the understanding of humans and the environment. | 62(9) | 855 | Mayo Clinic proceedings | [
{
"affiliation": "",
"forename": "M A",
"identifier": "",
"initials": "MA",
"lastname": "Shampo"
},
{
"affiliation": "",
"forename": "R A",
"identifier": "",
"initials": "RA",
"lastname": "Kyle"
}
] | 1987-09 | 3306184 | D001118:Argentina; D049672:History, 19th Century; D049673:History, 20th Century; D010163:Paleontology / Q000266:history*; D010678:Philately | D019215:Biography; D016456:Historical Article; D016428:Journal Article | 10.1016/s0025-6196(12)62343-x | [] | false | eng | Mayo Clin Proc | 0405543 | 0025-6196 | England | [] | "2024-08-13T08:46:10.443762Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
A formal mortality analysis for populations of unicellular organisms (Saccharomyces cerevisiae). | 38(3) | 231-43 | A theoretical analysis of the reproductive capacity of yeast (Saccharomyces cerevisiae) under different experimental settings reveals interesting patterns and inter-experimental relations of mortality in yeast. The data on yeast lifespan were derived from experimental research by Meisel (Untersuchungen ueber die Korrelation von Abtoetung und Lebensspannenverkuerzung durch mutagene Agentien bei Hefezellen (Thesis) Cologne, 1984). The analysis is based on the formulation of a "weak senescence principle". From this the structure of age-specific mortality is defined and employed as the functional constituent of three hierarchical types of mortality models. Model A consists of one such constituent, model B includes many of these, and in model C mortality is given a phase structure in addition. The models incorporate a few basic hypotheses on "damage" and "ageing", on partitions into subpopulations, and on mortality "shifts", according to the particular experimental treatment. It is shown that the theoretical distributions derived from these models and hypotheses yield extremely good fits to the experimental data. | Mechanisms of ageing and development | [
{
"affiliation": "",
"forename": "H J",
"identifier": "",
"initials": "HJ",
"lastname": "Pohley"
}
] | 1987-05 | 3306185 | D002454:Cell Differentiation; D008433:Mathematics; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000254:growth & development*; D013997:Time Factors | D016428:Journal Article | 10.1016/0047-6374(87)90092-3 | [] | false | eng | Mech Ageing Dev | 0347227 | 0047-6374 | Ireland | [] | "2024-08-13T08:46:10.445748Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[Current problems of hyperprolactinemia. II. Selection and systematization of the treatment]. | 89(3) | 122-7 | Medicina clinica | [
{
"affiliation": "",
"forename": "P P",
"identifier": "",
"initials": "PP",
"lastname": "García-Luna"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Leal-Cerro"
},
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Astorga Jiménez"
}
] | 1987-06-13 | 3306186 | D001971:Bromocriptine / Q000627:therapeutic use; D018492:Dopamine Antagonists; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000188:drug therapy / Q000628:therapy*; D010911:Pituitary Neoplasms / Q000150:complications / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy; D013965:Thyroidectomy | D016428:Journal Article; D016454:Review | D018492:Dopamine Antagonists; D001971:Bromocriptine | [] | false | spa | Problemas actuales de la hiperprolactinemia. II. Elección y sistematización del tratamiento. | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.446670Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[Strain variations of Candida albicans and sensitivity to antifungal agents]. | 89(3) | 129 | Medicina clinica | [
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Casal Román"
},
{
"affiliation": "",
"forename": "M J",
"identifier": "",
"initials": "MJ",
"lastname": "Linares Sicilia"
},
{
"affiliation": "",
"forename": "C M",
"identifier": "",
"initials": "CM",
"lastname": "Blanco Domínguez"
}
] | 1987-06-13 | 3306187 | D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000145:classification*; D006801:Humans; D008826:Microbial Sensitivity Tests | D016422:Letter | D000935:Antifungal Agents | [] | false | spa | Biovariedades de Candida albicans y sensibilidad a antifúngicos. | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.447629Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[Value of captopril in systemic lupus erythematosus with arterial hypertension and renal insufficiency]. | 89(3) | 129-30 | Medicina clinica | [
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Cervera"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Font"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Ingelmo"
}
] | 1987-06-13 | 3306188 | D000293:Adolescent; D002216:Captopril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007676:Kidney Failure, Chronic / Q000150:complications*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* | D002363:Case Reports; D016422:Letter | D002216:Captopril | [] | false | spa | Interés del captopril en el lupus eritematoso sistémico con hipertensión arterial e insuficiencia renal. | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.448420Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[Graft versus host disease. Analysis of 131 cases of bone marrow transplant]. | 89(3) | 89-94 | Medicina clinica | [
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Rozman"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Grañena"
},
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Carreras"
},
{
"affiliation": "",
"forename": "P",
"identifier": "",
"initials": "P",
"lastname": "Marín"
},
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Martín"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Palou"
},
{
"affiliation": "",
"forename": "J M",
"identifier": "",
"initials": "JM",
"lastname": "Mascaró"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Bruguera"
}
] | 1987-06-13 | 3306189 | D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D016026:Bone Marrow Transplantation; D002648:Child; D005260:Female; D006086:Graft vs Host Disease / Q000145:classification / Q000209:etiology*; D006801:Humans; D007938:Leukemia / Q000628:therapy; D008297:Male; D014181:Transplantation Immunology | D004740:English Abstract; D016428:Journal Article | [] | false | spa | Enfermedad del injerto contra el huésped. Análisis de 131 casos de trasplante de medula ósea. | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.449667Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
[Prognosis in acute non-lymphoblastic leukemia]. | 89(4) | 150-2 | Medicina clinica | [
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Sierra"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Rozman"
}
] | 1987-06-20 | 3306191 | D000208:Acute Disease; D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D011379:Prognosis | D016428:Journal Article; D016454:Review | D000970:Antineoplastic Agents | [] | false | spa | Pronóstico de la leucemia aguda no linfoblástica. | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.450444Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[The placebo effect]. | 89(4) | 153-6 | Medicina clinica | [
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Pérez Alvarez"
}
] | 1987-06-20 | 3306192 | D006801:Humans; D010919:Placebos / Q000627:therapeutic use* | D016428:Journal Article; D016454:Review | D010919:Placebos | [] | false | spa | El efecto placebo. | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.451221Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[Comparison of radioimmunoassay with enzyme immunoassay in the detection of serum antibodies against the human immunodeficiency virus]. | 89(4) | 144-6 | Medicina clinica | [
{
"affiliation": "",
"forename": "M A",
"identifier": "",
"initials": "MA",
"lastname": "Abad"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Leal"
},
{
"affiliation": "",
"forename": "J A",
"identifier": "",
"initials": "JA",
"lastname": "Pineda"
},
{
"affiliation": "",
"forename": "M A",
"identifier": "",
"initials": "MA",
"lastname": "Velardo"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Muñoz"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Pascual"
},
{
"affiliation": "",
"forename": "F",
"identifier": "",
"initials": "F",
"lastname": "García de Pesquera"
},
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Lissen"
}
] | 1987-06-20 | 3306190 | D000914:Antibodies, Viral / Q000032:analysis*; D006678:HIV / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D011863:Radioimmunoassay | D003160:Comparative Study; D004740:English Abstract; D016428:Journal Article | D000914:Antibodies, Viral | [] | false | spa | Comparación de radioinmunoanálisis frente a enzimoinmunoanálisis en la detección de anticuerpos séricos contra el virus de la inmunodeficiencia humana. | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.452207Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[Resistance of urinary flora from sources outside the hospital]. | 89(4) | 175 | Medicina clinica | [
{
"affiliation": "",
"forename": "G",
"identifier": "",
"initials": "G",
"lastname": "Tamborero"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Jiménez"
},
{
"affiliation": "",
"forename": "I",
"identifier": "",
"initials": "I",
"lastname": "López"
},
{
"affiliation": "",
"forename": "G",
"identifier": "",
"initials": "G",
"lastname": "Sánchez"
}
] | 1987-06-20 | 3306193 | D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D007709:Klebsiella / Q000187:drug effects / Q000302:isolation & purification*; D011511:Proteus / Q000187:drug effects / Q000302:isolation & purification*; D013210:Staphylococcus / Q000187:drug effects / Q000302:isolation & purification*; D014556:Urine / Q000382:microbiology* | D016422:Letter | D000900:Anti-Bacterial Agents | [] | false | spa | Resistencia de la flora urinaria extrahospitalaria. | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.454330Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[Effects of antibiotics on phagocytic cells: clinical importance]. | 89(5) | 209-14 | Medicina clinica | [
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Burgaleta"
},
{
"affiliation": "",
"forename": "T",
"identifier": "",
"initials": "T",
"lastname": "Moreno"
}
] | 1987-06-27 | 3306194 | D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D006801:Humans; D009503:Neutropenia / Q000139:chemically induced; D010586:Phagocytes / Q000187:drug effects* / Q000378:metabolism | D016428:Journal Article; D016454:Review | D000900:Anti-Bacterial Agents | [] | false | spa | Efectos de los antibióticos sobre las células fagocíticas: importancia clínica. | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.455052Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[Diagnosis of invasive pulmonary aspergillosis]. | 89(5) | 216 | Medicina clinica | [
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Sala-Mateus"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Puig de la Bellacasa"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Torres Martí"
},
{
"affiliation": "",
"forename": "M T",
"identifier": "",
"initials": "MT",
"lastname": "Jiménez de Anta"
}
] | 1987-06-27 | 3306195 | D000368:Aged; D000369:Aged, 80 and over; D001228:Aspergillosis / Q000175:diagnosis*; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D005455:Fluorescent Antibody Technique; D006801:Humans; D008172:Lung Diseases, Fungal / Q000175:diagnosis*; D008297:Male | D002363:Case Reports; D016422:Letter | [] | false | spa | Diagnóstico de la aspergilosis pulmonar invasiva. | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.455865Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
[Captopril: is it useful in the hypertensive crisis?]. | 89(5) | 216-7 | Medicina clinica | [
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Rodríguez"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Martínez"
},
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Canela"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Torres"
}
] | 1987-06-27 | 3306196 | D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D013997:Time Factors | D016422:Letter | D002216:Captopril | [] | false | spa | Captopril: es útil en la crisis hipertensiva? | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.456944Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[Reconsideration of plasmapheresis treatment of renal post-transplant recurrence of segmental and focal hyalinosis]. | 89(5) | 219 | Medicina clinica | [
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Franco"
},
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Pérez"
},
{
"affiliation": "",
"forename": "F",
"identifier": "",
"initials": "F",
"lastname": "Anaya"
},
{
"affiliation": "",
"forename": "F",
"identifier": "",
"initials": "F",
"lastname": "Valderrábano"
}
] | 1987-06-27 | 3306197 | D000293:Adolescent; D005921:Glomerulonephritis / Q000628:therapy*; D005923:Glomerulosclerosis, Focal Segmental / Q000628:therapy*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D010956:Plasmapheresis; D011183:Postoperative Complications / Q000628:therapy*; D012008:Recurrence | D002363:Case Reports; D016422:Letter | [] | false | spa | Reconsideración del tratamiento con plasmaféresis de la recidiva postrasplante renal de hialinosis segmentaria y focal. | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.457741Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
[Captopril and nifedipine: comparative study of the immediate arterial pressure response in various grades of hypertension]. | 89(6) | 224-9 | Medicina clinica | [
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Ocón"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "López Lillo"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Ballarín"
},
{
"affiliation": "",
"forename": "G",
"identifier": "",
"initials": "G",
"lastname": "del Río"
},
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Castellet"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Mora"
}
] | 1987-07-04 | 3306198 | D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D012083:Renin / Q000097:blood | D003160:Comparative Study; D004740:English Abstract; D016428:Journal Article | D002216:Captopril; D012083:Renin; D009543:Nifedipine | [] | false | spa | Captopril y nifedipina: estudio comparativo de la respuesta inmediata de la presión arterial en varios grados de hipertensión. | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.458980Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[Endoscopic papillotomy. Comparative analysis of the effect of ceruletide and octylonium bromide as modifiers of the motility of the duodenum and the papillary sphincter]. | 89(6) | 230-4 | Medicina clinica | [
{
"affiliation": "",
"forename": "J M",
"identifier": "",
"initials": "JM",
"lastname": "Bordas"
},
{
"affiliation": "",
"forename": "X",
"identifier": "",
"initials": "X",
"lastname": "Bona"
},
{
"affiliation": "",
"forename": "F",
"identifier": "",
"initials": "F",
"lastname": "Mondelo"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Rodés"
}
] | 1987-07-04 | 3306199 | D000368:Aged; D014670:Ampulla of Vater / Q000187:drug effects / Q000601:surgery*; D002108:Ceruletide / Q000494:pharmacology*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004386:Duodenum / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D009126:Muscle Relaxation / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D011897:Random Allocation | D016430:Clinical Trial; D003160:Comparative Study; D018848:Controlled Clinical Trial; D004740:English Abstract; D016428:Journal Article; D016449:Randomized Controlled Trial | D000644:Quaternary Ammonium Compounds; C013934:octylonium; D002108:Ceruletide | [] | false | spa | Papilotomía endoscópica. Análisis comparativo del efecto del ceruletide y del bromuro de octilonio como modificadores de la motilidad del duodeno y del esfínter papilar. | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.461017Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[Infections caused by Salmonella and acquired immunodeficiency syndrome]. | 89(6) | 258-9 | Medicina clinica | [
{
"affiliation": "",
"forename": "G",
"identifier": "",
"initials": "G",
"lastname": "Gaspar Alonso-Vega"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Rodríguez Méndez"
},
{
"affiliation": "",
"forename": "L",
"identifier": "",
"initials": "L",
"lastname": "Sánchez Martínez"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Martínez-Conde"
}
] | 1987-07-04 | 3306200 | D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D012480:Salmonella Infections / Q000209:etiology*; D012486:Salmonella typhimurium; D018805:Sepsis / Q000209:etiology | D016422:Letter | [] | false | spa | Infecciones por Salmonella y síndrome de inmunodeficiencia adquirida. | Med Clin (Barc) | 0376377 | 0025-7753 | Spain | [] | "2024-08-13T08:46:10.461887Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Hypertension in blacks. | 71(5) | 1013-29 | Hypertension represents a problem of special importance in the black patient primarily because of frequency and increased severity. Differences between hypertension in blacks and whites in the United States seem to be mostly epidemiological, pathophysiological, and in responsiveness to drug therapy. Black hypertensives seem to have more of a salt-sensitive, volume-dependent type of hypertension and, therefore, diuretic therapy appears to be particularly useful. Agents that seem to depend more on a stimulated renin-angiotensin-aldosterone system are generally less effective as monotherapy in this group of patients. However, proper combinations of low dose diuretics, with almost any other therapeutic agent, seems to produce a responsiveness in the black hypertensive that is equal to comparable white patients. | The Medical clinics of North America | [
{
"affiliation": "",
"forename": "E",
"identifier": "",
"initials": "E",
"lastname": "Saunders"
}
] | 1987-09 | 3306202 | D000367:Age Factors; D000959:Antihypertensive Agents / Q000627:therapeutic use; D044383:Black People; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D014481:United States | D016428:Journal Article; D016454:Review | D000959:Antihypertensive Agents | 10.1016/s0025-7125(16)30824-0 | [] | false | eng | Med Clin North Am | 2985236R | 0025-7125 | United States | [] | "2024-08-13T08:46:10.462594Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Myths about hypertension in the elderly. | 71(5) | 1003-11 | Many of the traditional concepts concerning hypertension in the elderly have turned out to be myths. Large randomized clinical trials have shown that antihypertensive therapy reduces the risk of cardiovascular mortality for elderly patients with diastolic hypertension. Elderly patients adhere well to prescribed regimens and they tolerate antihypertensive drugs as well as younger patients do. An oral diuretic is the agent of choice to initiate treatment for elderly patients with either diastolic or isolated systolic hypertension. | The Medical clinics of North America | [
{
"affiliation": "",
"forename": "R W",
"identifier": "",
"initials": "RW",
"lastname": "Gifford"
}
] | 1987-09 | 3306201 | D000375:Aging; D001294:Attitude to Health; D001794:Blood Pressure; D001795:Blood Pressure Determination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology*; D008297:Male | D016428:Journal Article; D016454:Review | 10.1016/s0025-7125(16)30823-9 | [] | false | eng | Med Clin North Am | 2985236R | 0025-7125 | United States | [] | "2024-08-13T08:46:10.463610Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Hypertension in pregnancy. | 71(5) | 1031-43 | This article reviews the hypertensive complications of pregnancy, focusing on the pathophysiology and management of pre-eclampsia. These are areas where data are sparse and authoritative disagreements loud. We advocate an intermediate approach where treatment regimens aim at a successful conclusion of the pregnancy, without residual pathology in the mother. | The Medical clinics of North America | [
{
"affiliation": "",
"forename": "P",
"identifier": "",
"initials": "P",
"lastname": "Maikranz"
},
{
"affiliation": "",
"forename": "M D",
"identifier": "",
"initials": "MD",
"lastname": "Lindheimer"
}
] | 1987-09 | 3306203 | D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D011225:Pre-Eclampsia / Q000209:etiology* / Q000503:physiopathology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology* | D016428:Journal Article; D013487:Research Support, U.S. Gov't, P.H.S.; D016454:Review | D000959:Antihypertensive Agents | 10.1016/s0025-7125(16)30825-2 | [] | false | eng | Med Clin North Am | 2985236R | 0025-7125 | United States | [
{
"agency": "NICHD NIH HHS",
"country": "United States",
"grant_acronym": "HD",
"grant_id": "HD 5572"
},
{
"agency": "NCRR NIH HHS",
"country": "United States",
"grant_acronym": "RR",
"grant_id": "RR 55"
}
] | "2024-08-13T08:46:10.464563Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Epidemiologic considerations in defining hypertension. | 71(5) | 785-801 | Definitions of hypertension have historically been based on at least one of three concepts. The first approach identifies thresholds of hypertension based on the frequency of occurrence in the population. The statistical approach designates a point in the distribution (e.g., the 95th percentile), as the threshold for hypertension. This distribution method identifies different limits for hypertension depending on the age, sex, and race, of the population, all of which affect the average pressure. Although distribution curves do not by themselves identify thresholds for intervention, they are useful for examining changes in population groups over time. The second approach to defining hypertension relates pressures to the risk of morbidity and mortality and is characterized by a continuously graded curve with no clear categorical thresholds. Studies correlating both diastolic and systolic pressures with cardiovascular complications demonstrate continuous risks from lowest to highest values for both sexes, all ages, and both blacks and whites in the United States. The blood pressure-risk relationship provides a compelling rationale for treatment but does not by itself define thresholds for the initiation of therapy. The third approach uses data from clinical intervention trials to identify thresholds where the benefits of therapy outweigh the costs and side effects of long-term treatment. Although results of large randomized trials have clearly demonstrated reductions in morbidity and mortality by lowering blood pressures, consensus on the lowest threshold within the mild range for which antihypertensive drug treatment is recommended has not been reached. Because an optimal definition of hypertension must encompass all three approaches and the resultant classification scheme must be sufficient for all purposes, attempts to refine and improve upon the presently recommended thresholds will undoubtedly continue. | The Medical clinics of North America | [
{
"affiliation": "",
"forename": "E J",
"identifier": "",
"initials": "EJ",
"lastname": "Roccella"
},
{
"affiliation": "",
"forename": "A E",
"identifier": "",
"initials": "AE",
"lastname": "Bowler"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Horan"
}
] | 1987-09 | 3306204 | D000367:Age Factors; D001794:Blood Pressure; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D006973:Hypertension / Q000145:classification / Q000453:epidemiology*; D008297:Male; D012737:Sex Factors; D014481:United States | D016428:Journal Article; D016454:Review | 10.1016/s0025-7125(16)30808-2 | [] | false | eng | Med Clin North Am | 2985236R | 0025-7125 | United States | [] | "2024-08-13T08:46:10.465488Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Vascular changes in hypertension. | 71(5) | 827-41 | Hypertension can directly damage blood vessels, and leads to renal failure, intracranial bleeds, and lacunar infarctions. Of equal importance is the effect of hypertension on the development of atherosclerosis. Specific changes in both the microvasculature and macrovasculature vary depending on the degree and rapidity of blood pressure elevation. Changes in the intima and media can lead to significant narrowing of vessels and ischemia in various tissues. In addition, changes in small-resistance vessels contribute to changes in peripheral-vasculature resistance and thus affect blood pressure regulation. Treatment of moderate to severe elevation in blood pressure clearly results in a decrease in the incidence of stroke. However, evidence that treating mild hypertension reduces coronary events is less convincing. Antihypertensive therapy may result in partial regression of vascular changes, especially fibrinoid necrosis seen in malignant hypertension, but more work needs to be done to clearly define the roles of specific drugs in preventing or regressing hypertensive vascular disease. | The Medical clinics of North America | [
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Leitschuh"
},
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Chobanian"
}
] | 1987-09 | 3306205 | D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D007674:Kidney Diseases / Q000209:etiology; D008297:Male; D014652:Vascular Diseases / Q000209:etiology* / Q000473:pathology | D016428:Journal Article; D013487:Research Support, U.S. Gov't, P.H.S.; D016454:Review | D000959:Antihypertensive Agents | 10.1016/s0025-7125(16)30811-2 | [] | false | eng | Med Clin North Am | 2985236R | 0025-7125 | United States | [
{
"agency": "NHLBI NIH HHS",
"country": "United States",
"grant_acronym": "HL",
"grant_id": "HL07224"
},
{
"agency": "NHLBI NIH HHS",
"country": "United States",
"grant_acronym": "HL",
"grant_id": "HL18318"
}
] | "2024-08-13T08:46:10.467872Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Renal parenchymal involvement in essential hypertension. | 71(5) | 843-58 | This article has reviewed the involvement of the kidney as a target organ of essential hypertension. Since Bright first made the association of renal disease and hypertension in 1836, the nature of this relationship has been debated. Although there is evidence implicating abnormalities of renal function in the pathogenesis of essential hypertension, hypertension frequently precedes histologic evidence of alterations in renal structure. Nephrosclerosis, or hardening of the kidney, is the term used to describe the histologic changes occurring in the kidney as the result of hypertension. It can be though of as an acceleration of the normal aging process of the renal vasculature. Glomerular and tubular changes have been traditionally thought to be ischemic in origin. Experimental evidence supports the notion that, as renal function is lost, intraglomerular hypertension develops and may be responsible for additional nephron loss in hypertension. This idea may have therapeutic implications for hypertensive patients with renal insufficiency in that agents that reduce both systemic and intraglomerular pressure may be preferable. Hemodynamically, early hypertension is often characterized by normal peripheral and renal vascular resistance and an increased cardiac output. In established hypertension, cardiac output is usually normal, and peripheral and renal vascular resistances are increased. Renal blood flow is reduced, glomerular filtration rate is maintained, and the filtration fraction rises. In the absence of an accelerated malignant phase, renal failure is uncommon in essential hypertension. Males and blacks are most sensitive to the vascular damage of essential hypertension. Essential hypertension remains an important cause of end-stage renal disease, especially in blacks. Atherosclerotic obstruction of the renal arteries may be a more common cause of renal failure in patients with essential hypertension than has been previously recognized. There are few sensitive markers of early renal involvement in essential hypertension. Several studies of sensitive markers are promising and may detect patients who are prone to renal injury and deserve more aggressive treatment. Malignant hypertension is characterized pathologically by vascular changes of proliferative endarteritis and fibrinoid necrosis. Fortunately, its frequency is decreasing because of early identification and effective treatment of essential hypertension. Effective treatment of severe and malignant hypertension clearly leads to stabilization (and occasionally improvement) of renal function.(ABSTRACT TRUNCATED AT 400 WORDS) | The Medical clinics of North America | [
{
"affiliation": "",
"forename": "G L",
"identifier": "",
"initials": "GL",
"lastname": "Schwartz"
},
{
"affiliation": "",
"forename": "C G",
"identifier": "",
"initials": "CG",
"lastname": "Strong"
}
] | 1987-09 | 3306206 | D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000150:complications*; D006974:Hypertension, Malignant / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000503:physiopathology; D009400:Nephrosclerosis / Q000378:metabolism / Q000473:pathology*; D012079:Renal Circulation | D016428:Journal Article; D016454:Review | 10.1016/s0025-7125(16)30812-4 | [] | false | eng | Med Clin North Am | 2985236R | 0025-7125 | United States | [] | "2024-08-13T08:46:10.468645Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Cations and hypertension: sodium, potassium, calcium, and magnesium. | 71(5) | 859-75 | The association between sodium intake and hypertension has been studied for almost a century. More recently, it has been suggested that abnormalities in dietary intake of potassium, calcium, and magnesium may play a major role in the pathogenesis of hypertension. A critical analysis of selected data from animal and human studies is discussed. | The Medical clinics of North America | [
{
"affiliation": "",
"forename": "M H",
"identifier": "",
"initials": "MH",
"lastname": "Maxwell"
},
{
"affiliation": "",
"forename": "A U",
"identifier": "",
"initials": "AU",
"lastname": "Waks"
}
] | 1987-09 | 3306207 | D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology*; D004032:Diet; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D008274:Magnesium / Q000378:metabolism / Q000506:poisoning*; D008297:Male; D011188:Potassium / Q000378:metabolism / Q000494:pharmacology*; D012964:Sodium / Q000494:pharmacology / Q000506:poisoning* | D016428:Journal Article; D016454:Review | D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium | 10.1016/s0025-7125(16)30813-6 | [] | false | eng | Med Clin North Am | 2985236R | 0025-7125 | United States | [] | "2024-08-13T08:46:10.469880Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
The renin-angiotensin systems. | 71(5) | 877-95 | The renin-angiotensin systems are important regulators of cardiovascular homeostasis and participate in a variety of pathological conditions. Recent advances have not only clarified the functioning of the systemic renin cascade but have also indicated the importance of the generation of angiotensin in tissues. | The Medical clinics of North America | [
{
"affiliation": "",
"forename": "R N",
"identifier": "",
"initials": "RN",
"lastname": "Re"
}
] | 1987-09 | 3306208 | D006706:Homeostasis; D006801:Humans; D006929:Hyperaldosteronism / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D006978:Hypertension, Renovascular / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D012084:Renin-Angiotensin System | D016428:Journal Article; D016454:Review | 10.1016/s0025-7125(16)30814-8 | [] | false | eng | Med Clin North Am | 2985236R | 0025-7125 | United States | [] | "2024-08-13T08:46:10.470596Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Essential hypertension: neural considerations. | 71(5) | 897-905 | Current evidence suggests that the sympathetic nervous system plays a predominant role in some fraction of essential hypertension. Patients in whom such mechanisms are likely to be operative are young people with mild or labile hypertension. These mechanisms are expressed clinically through orthostatic hypertension, rapid heart rate, modestly elevated cardiac output, and normal or slightly elevated peripheral vascular resistance. The vascular resistance is inappropriately high for the level of cardiac output, and this is reflected in a mildly elevated blood pressure. This evidence carries therapeutic implications and suggests that sympatholytic drugs should be the first line of therapy. An additional pressor mechanism may arise from increased sympathetic activity along renal efferent nerves that impairs sodium excretion and another possible mechanism is stimulation of brain centers through impulses from the kidneys carried in renal afferent nerves. | The Medical clinics of North America | [
{
"affiliation": "",
"forename": "H P",
"identifier": "",
"initials": "HP",
"lastname": "Dustan"
}
] | 1987-09 | 3306209 | D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D012964:Sodium / Q000378:metabolism; D013564:Sympathetic Nervous System | D016428:Journal Article; D016454:Review | D012964:Sodium | 10.1016/s0025-7125(16)30815-x | [] | false | eng | Med Clin North Am | 2985236R | 0025-7125 | United States | [] | "2024-08-13T08:46:10.471356Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Clinical aspects of endocrine hypertension. | 71(5) | 907-20 | Distinct hypertensive syndromes clearly related to overproduction of certain hormones are increasingly being recognized. The ability to recognize these disorders has come as a result of better understanding of their pathophysiology and the availability of sensitive and accurate diagnostic tools. The particular appeal of making the diagnosis centers around the potential curability of the hypertension with correction of the hormonal abnormality. | The Medical clinics of North America | [
{
"affiliation": "",
"forename": "E L",
"identifier": "",
"initials": "EL",
"lastname": "Bravo"
}
] | 1987-09 | 3306210 | D003480:Cushing Syndrome / Q000150:complications / Q000503:physiopathology; D003900:Desoxycorticosterone / Q000378:metabolism; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000503:physiopathology; D006973:Hypertension / Q000209:etiology*; D007674:Kidney Diseases / Q000150:complications / Q000503:physiopathology; D008901:Mineralocorticoids / Q000378:metabolism; D010673:Pheochromocytoma / Q000150:complications / Q000503:physiopathology | D016428:Journal Article; D016454:Review | D008901:Mineralocorticoids; D003900:Desoxycorticosterone | 10.1016/s0025-7125(16)30816-1 | [] | false | eng | Med Clin North Am | 2985236R | 0025-7125 | United States | [] | "2024-08-13T08:46:10.472231Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
Nonpharmacologic therapy of hypertension. | 71(5) | 921-33 | At least seven nondrug therapies have been shown to reduce the blood pressure in some hypertensive patients. Although each has its detractors, I believe most should be utilized in the therapy of most hypertensives. Some, such as weight reduction for the obese, decreased saturated fat intake, regular isotonic exercise, and moderation of alcohol, can be enthusiastically advocated for everyone, since they may accomplish additional improvements in overall cardiovascular risk beyond their effect on blood pressure. Others such as moderate sodium restriction, adequate dietary sources of potassium, magnesium, and calcium, and relaxation therapy, can be helpful in at least some hypertensives and should be appropriately applied to the therapy of those who may benefit. To varying degrees, nondrug therapies should be included in the treatment of all patients with hypertension. | The Medical clinics of North America | [
{
"affiliation": "",
"forename": "N M",
"identifier": "",
"initials": "NM",
"lastname": "Kaplan"
}
] | 1987-09 | 3306211 | D001794:Blood Pressure; D001835:Body Weight; D004032:Diet; D004039:Diet, Sodium-Restricted; D005260:Female; D006801:Humans; D006973:Hypertension / Q000628:therapy*; D007537:Isometric Contraction; D008297:Male; D009119:Muscle Contraction; D012063:Relaxation | D016428:Journal Article; D016454:Review | 10.1016/s0025-7125(16)30817-3 | [] | false | eng | Med Clin North Am | 2985236R | 0025-7125 | United States | [] | "2024-08-13T08:46:10.474131Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Diuretics in the management of hypertension. | 71(5) | 935-46 | Thiazide diuretics have been in use for over 30 years in the treatment of hypertension. Their action results in a reduction in peripheral resistance without a significant decrease in cardiac output or a major shift in plasma volume. They are as or more effective than any of the other antihypertensive agents when used as monotherapy and can serve as baseline therapy in combination with any of the available adrenergic, converting enzyme-inhibiting agents, or calcium-entry blockers. There is a high degree of patient acceptance; titration to an effective dosage is relatively easy; and cost, relatively low. Although certain undesirable metabolic changes may occur following the use of these agents, most of them are controllable, and there is no evidence to date that they offset the benefits achieved by blood pressure lowering. Asymptomatic elevated uric acids have not been shown to be of great significance. If gout occurs, it can be managed. Alterations in glucose metabolism may occur, and in some patients, it appears that blood glucose levels are elevated over time. This is not a desirable metabolic change, but is one of doubtful prognostic significance. Changes in lipids are generally short-term, and in the major clinical trials, lipid levels have not remained elevated with a continuation of diuretic therapy. Although diuretics produce hypokalemia in a fairly high percentage of patients, this is not generally severe (less than 3.3 mEq per liter) and usually does not produce symptoms. There is no firm evidence that the hypokalemia produced by diuretics predisposes the patient to severe arrhythmias or sudden death, although this point has been emphasized repeatedly in recent publications. Diuretics can usually be given without potassium-maintenance therapy. However, hypokalemia should be prevented in the elderly, in patients with ischemic heart disease, left ventricular hypertrophy and those on digitalis, or with diabetes. We prefer potassium-sparing agents along with a diuretic over supplements to prevent hypokalemia; the number of pills is kept at a reasonable level, and cost is minimized. Physicians should continue to prescribe diuretics as first-step therapy in the majority of patients to maximize therapeutic outcome. | The Medical clinics of North America | [
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Moser"
}
] | 1987-09 | 3306212 | D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004232:Diuretics / Q000627:therapeutic use*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* | D016428:Journal Article; D016454:Review | D004232:Diuretics; D002784:Cholesterol; D005947:Glucose | [] | false | eng | Med Clin North Am | 2985236R | 0025-7125 | United States | [] | "2024-08-13T08:46:10.474871Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Obesity hypertension. | 71(5) | 991-1001 | Obesity and hypertension are two major risk factors for the cardiovascular system. Whereas arterial hypertension increases afterload to the left ventricle, obesity produces an increase in stroke volume and increases preload. As a result of this double burden, the heart adapts with eccentric left ventricular hypertrophy. Contractility becomes impaired early in the course of obesity hypertension, and ventricular ectopy is observed. As a consequence, the obese hypertensive patient is at a high risk for congestive heart failure and sudden death. Despite the synergistic effects of obesity and hypertension on the heart, patients appear to be relatively protected from nephrosclerosis and coronary artery disease. These epidemiologic observations are supported by the pathophysiologic changes that take place in obesity hypertension. At any given level of arterial pressure, cardiac output and renal blood flow are elevated in obese hypertensive patients, whereas systemic and renal vascular resistance are decreased when compared to lean hypertensive patients. Because total peripheral resistance is considered the hemodynamic hallmark of arterial hypertension, systemic vascular complications may be less pronounced in obesity hypertension. Weight loss decreases preload, afterload to the left ventricle, and the sympathetic drive to the heart. Protecting the heart from these hypertrophic stimuli should be a major goal of preventive cardiology. | The Medical clinics of North America | [
{
"affiliation": "",
"forename": "R E",
"identifier": "",
"initials": "RE",
"lastname": "Schmieder"
},
{
"affiliation": "",
"forename": "F H",
"identifier": "",
"initials": "FH",
"lastname": "Messerli"
}
] | 1987-09 | 3306213 | D006333:Heart Failure / Q000209:etiology* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D009765:Obesity / Q000150:complications* | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't; D016454:Review | 10.1016/s0025-7125(16)30822-7 | [] | false | eng | Med Clin North Am | 2985236R | 0025-7125 | United States | [] | "2024-08-13T08:46:10.475712Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Optimistic analysis--chemical embryology in Cambridge 1920-42. | 31(3) | 247-68 | Medical history | [
{
"affiliation": "",
"forename": "J A",
"identifier": "",
"initials": "JA",
"lastname": "Witkowski"
}
] | 1987-07 | 3306218 | D000818:Animals; D001671:Biochemistry / Q000193:education / Q000266:history*; D004626:Embryology / Q000193:education / Q000266:history*; D004739:England; D049673:History, 20th Century; D014495:Universities / Q000266:history | D016456:Historical Article; D016428:Journal Article; D019477:Portrait | 10.1017/s0025727300046858 | [
{
"citation": "Experientia. 1969 Nov 15;25(11):1121-5",
"pmid": "4902878"
},
{
"citation": "J Hist Biol. 1984 Spring;17(1):1-11",
"pmid": "11611449"
},
{
"citation": "J Physiol. 1907 Mar 27;35(4):247-309",
"pmid": "16992858"
}
] | false | eng | Med Hist | 0401052 | 0025-7273 | England | [] | "2024-08-13T08:46:10.476803Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
High performance for expert systems: II. A system for leukaemia diagnosis. | 12(2) | 97-114 | A system for diagnosing leukaemia subtypes from monoclonal antibody test results has been programmed directly from the expertise of one immunologist. It gives an acceptable conclusion for 400 past cases, with summaries of its reasoning and suggestions for further tests. Its development included three major components: elicitation of the basic items of knowledge, formulation of a coordinated overall scheme, and representation in a computer language. All three were interdependent and required many cycles of trial and error, involving further discussions with the expert at all stages. By far the most difficult component was the formulation of a comprehensive specification for the problems of the domain, and this was only achieved when the knowledge engineer had gained a fair understanding of the application. The system is a tree-structured logic program written in PROLOG. This format facilitated experimentation with different knowledge representations, control of the interrelationships between rules and the elimination of errors. The problems of quality control and maintenance are of paramount importance for high-performance systems. | Medical informatics = Medecine et informatique | [
{
"affiliation": "",
"forename": "P L",
"identifier": "",
"initials": "PL",
"lastname": "Alvey"
},
{
"affiliation": "",
"forename": "N J",
"identifier": "",
"initials": "NJ",
"lastname": "Preston"
},
{
"affiliation": "",
"forename": "M F",
"identifier": "",
"initials": "MF",
"lastname": "Greaves"
}
] | 1987 | 3306215 | D003936:Diagnosis, Computer-Assisted; D003937:Diagnosis, Differential; D005103:Expert Systems; D006801:Humans; D007938:Leukemia / Q000175:diagnosis*; D012984:Software | D016428:Journal Article | 10.3109/14639238709003560 | [] | false | eng | Med Inform (Lond) | 7612096 | 0307-7640 | England | [] | "2024-08-13T08:46:10.477566Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
Obstetrical research in The Netherlands in the nineteenth century. | 31(3) | 281-305 | Medical history | [
{
"affiliation": "",
"forename": "A",
"identifier": "",
"initials": "A",
"lastname": "Hiddinga"
}
] | 1987-07 | 3306220 | D005260:Female; D005858:Germany; D049672:History, 19th Century; D006801:Humans; D007883:Legislation, Medical / Q000266:history; D009426:Netherlands; D009774:Obstetrics / Q000266:history*; D011247:Pregnancy | D003160:Comparative Study; D016456:Historical Article; D016428:Journal Article | 10.1017/s0025727300046871 | [
{
"citation": "Janus. 1978;65(1-2-3):21-44",
"pmid": "11610397"
},
{
"citation": "Tijdschr Geschied. 1983;96(3):433-53",
"pmid": "11636115"
}
] | false | eng | Med Hist | 0401052 | 0025-7273 | England | [] | "2024-08-13T08:46:10.478486Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Making a long story short: a note on men's height and mortality in England from the first through the nineteenth centuries. | 31(3) | 269-80 | Medical history | [
{
"affiliation": "",
"forename": "S J",
"identifier": "",
"initials": "SJ",
"lastname": "Kunitz"
}
] | 1987-07 | 3306219 | D000886:Anthropometry; D001827:Body Height; D004739:England; D049668:History, 15th Century; D049669:History, 16th Century; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049690:History, Ancient; D049691:History, Medieval; D006801:Humans; D008297:Male; D009026:Mortality | D016456:Historical Article; D016428:Journal Article | 10.1017/s002572730004686x | [
{
"citation": "Hum Biol. 1983 Feb;55(1):73-87",
"pmid": "6840749"
},
{
"citation": "Demography. 1984 Aug;21(3):271-95",
"pmid": "6383886"
},
{
"citation": "Hum Biol. 1985 Feb;57(1):77-95",
"pmid": "3886520"
},
{
"citation": "Am J Phys Anthropol. 1985 Sep;68(1):1-14",
"pmid": "4061595"
},
{
"citation": "Am J Phys Anthropol. 1985 Sep;68(1):79-85",
"pmid": "4061604"
},
{
"citation": "Econ Hist Rev. 1973;26:403-32",
"pmid": "11614415"
},
{
"citation": "Econ Hist Rev. 1981;34(3):469-76",
"pmid": "11614427"
},
{
"citation": "Econ Hist Rev. 1983;36(3):349-64",
"pmid": "11616909"
},
{
"citation": "J Interdiscip Hist. 1983;14(2):445-81",
"pmid": "11617349"
},
{
"citation": "J Hist Med Allied Sci. 1981 Oct;36(4):425-45",
"pmid": "7037928"
},
{
"citation": "Milbank Mem Fund Q Health Soc. 1977 Summer;55(3):405-28",
"pmid": "413067"
},
{
"citation": "Soc Sci Hist. 1982;6(4):453-82",
"pmid": "11633198"
},
{
"citation": "Am J Phys Anthropol. 1952 Dec;10(4):463-514",
"pmid": "13007782"
}
] | false | eng | Med Hist | 0401052 | 0025-7273 | England | [] | "2024-08-13T08:46:10.480633Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
The meaning of fractures: orthopaedics and the reform of British hospitals in the inter-war period. | 31(3) | 306-32 | Medical history | [
{
"affiliation": "",
"forename": "R",
"identifier": "",
"initials": "R",
"lastname": "Cooter"
}
] | 1987-07 | 3306221 | D050723:Fractures, Bone / Q000266:history*; D049673:History, 20th Century; D006761:Hospitals / Q000266:history*; D009985:Orthopedics / Q000266:history*; D006113:United Kingdom | D016456:Historical Article; D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | 10.1017/s0025727300046883 | [
{
"citation": "J Contemp Hist. 1985;20(4):503-20",
"pmid": "11617289"
},
{
"citation": "Br Med J. 1949 Apr 23;1(4607):720-2",
"pmid": "18125799"
},
{
"citation": "J Soc Policy. 1979 Jul;8(3):335-56",
"pmid": "10297554"
},
{
"citation": "Br J Surg. 1982 Oct;69(10):561-3",
"pmid": "6751454"
},
{
"citation": "Rehabil Lit. 1985 Nov-Dec;46(11-12):314-20",
"pmid": "4089307"
}
] | false | eng | Med Hist | 0401052 | 0025-7273 | England | [] | "2024-08-13T08:46:10.481815Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Structures and biological activities of vitamin D metabolites and their analogs. | 7(3) | 333-66 | Medicinal research reviews | [
{
"affiliation": "",
"forename": "N",
"identifier": "",
"initials": "N",
"lastname": "Ikekawa"
}
] | 1987 | 3306217 | D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002645:Chickens; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D051381:Rats; D013329:Structure-Activity Relationship; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology | D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't; D013486:Research Support, U.S. Gov't, Non-P.H.S.; D016454:Review | D014807:Vitamin D; D002118:Calcium | 10.1002/med.2610070304 | [] | false | eng | Med Res Rev | 8103150 | 0198-6325 | United States | [] | "2024-08-13T08:46:10.482458Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
A provincial surgeon and his obstetric practice: Thomas W. Jones of Henley-in-Arden, 1764-1846. | 31(3) | 333-48 | Medical history | [
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Lane"
}
] | 1987-07 | 3306222 | D004739:England; D013502:General Surgery / Q000266:history; D049671:History, 18th Century; D049672:History, 19th Century; D008373:Manuscripts as Topic; D009774:Obstetrics / Q000266:history; D010820:Physicians / Q000266:history; D011996:Records | D019215:Biography; D016456:Historical Article; D016428:Journal Article; D013485:Research Support, Non-U.S. Gov't | 10.1017/s0025727300046895 | [] | false | eng | Med Hist | 0401052 | 0025-7273 | England | [] | "2024-08-13T08:46:10.483390Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
High performance for expert systems: I. Escaping from the demonstrator class. | 12(2) | 85-95 | An investigation was performed to elucidate the problems of converting a demonstrator expert system for leukaemia diagnosis into a large high-performance system. Analysis of the logical completeness of the demonstrator system revealed only minor errors and a limited representation of the domain. Most of its test cases were quite simple and correction of the minor errors raised the performance to 94%. However, the remaining cases were very complex and it is doubtful whether the system could handle them without fundamental changes to its representation of the domain. Demonstrator systems can function with an imperfect view of the domain since the small sacrifice of accuracy is of little consequence; but in a high-performance system the imperfections must be corrected before extra detail is added. The use of default mechanisms for making specific conclusions was harmful because they concealed errors, and a numerical method for handling uncertainty contributed nothing of value to the system. | Medical informatics = Medecine et informatique | [
{
"affiliation": "",
"forename": "P L",
"identifier": "",
"initials": "PL",
"lastname": "Alvey"
},
{
"affiliation": "",
"forename": "C D",
"identifier": "",
"initials": "CD",
"lastname": "Myers"
},
{
"affiliation": "",
"forename": "M F",
"identifier": "",
"initials": "MF",
"lastname": "Greaves"
}
] | 1987 | 3306214 | D003936:Diagnosis, Computer-Assisted; D003937:Diagnosis, Differential; D005103:Expert Systems; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* | D016428:Journal Article | 10.3109/14639238709003559 | [] | false | eng | Med Inform (Lond) | 7612096 | 0307-7640 | England | [] | "2024-08-13T08:46:10.484118Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
A surgeon's private practice in the nineteenth century. Sir William Fergusson's Edinburgh day books 1832-39, with some extracts from his London day books 1839-77. | 31(3) | 349-53 | Medical history | [
{
"affiliation": "",
"forename": "J B",
"identifier": "",
"initials": "JB",
"lastname": "Wilson"
}
] | 1987-07 | 3306223 | D005249:Fees and Charges / Q000266:history; D013502:General Surgery / Q000266:history; D049672:History, 19th Century; D008131:London; D008373:Manuscripts as Topic; D010820:Physicians / Q000266:history; D011996:Records; D012606:Scotland | D019215:Biography; D016456:Historical Article; D016428:Journal Article | 10.1017/s0025727300046901 | [
{
"citation": "J R Coll Surg Edinb. 1977 Mar;22(2):127-35",
"pmid": "323477"
},
{
"citation": "Ann R Coll Surg Engl. 1977 Nov;59(6):484-7",
"pmid": "337884"
},
{
"citation": "J R Coll Surg Edinb. 1986 Dec;31(6):372-4",
"pmid": "3543321"
}
] | false | eng | Med Hist | 0401052 | 0025-7273 | England | [] | "2024-08-13T08:46:10.484946Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Illustrations from the Wellcome Institute Library. The Sami Haddad collection of Arabic medical manuscripts. | 31(3) | 354-7 | Medical history | [
{
"affiliation": "",
"forename": "L I",
"identifier": "",
"initials": "LI",
"lastname": "Conrad"
}
] | 1987-07 | 3306224 | D001868:Book Collecting; D049673:History, 20th Century; D049691:History, Medieval; D008374:Manuscripts, Medical as Topic; D008514:Medicine, Arabic | D019215:Biography; D016456:Historical Article; D016428:Journal Article | 10.1017/s0025727300046913 | [] | false | eng | Med Hist | 0401052 | 0025-7273 | England | [] | "2024-08-13T08:46:10.486823Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
[Plague--a forgotten but uneradicated disease]. | 84(18) | 1549-52 | Lakartidningen | [
{
"affiliation": "",
"forename": "P E",
"identifier": "",
"initials": "PE",
"lastname": "Abom"
}
] | 1987-04-29 | 3306225 | D000818:Animals; D004199:Disease Vectors; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049690:History, Ancient; D049691:History, Medieval; D006801:Humans; D010930:Plague / Q000266:history* / Q000635:transmission | D016456:Historical Article; D016428:Journal Article | [] | false | swe | Pest--"bortglömd" men inte utrotad sjukdom. | Lakartidningen | 0027707 | 0023-7205 | Sweden | [] | "2024-08-13T08:46:10.487746Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
Drugs for the treatment of traumatic brain injury. | 7(3) | 271-305 | Medicinal research reviews | [
{
"affiliation": "",
"forename": "E J",
"identifier": "",
"initials": "EJ",
"lastname": "Cragoe"
}
] | 1987 | 3306216 | D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001812:Blood-Brain Barrier; D001930:Brain Injuries / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D004232:Diuretics / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004573:Electrolytes / Q000378:metabolism; D005449:Fluorenes / Q000627:therapeutic use*; D006016:Glycolates / Q000627:therapeutic use*; D006801:Humans; D066298:In Vitro Techniques; D007192:Indenes / Q000627:therapeutic use* | D016428:Journal Article; D016454:Review | D004232:Diuretics; D004573:Electrolytes; D005449:Fluorenes; D006016:Glycolates; D007192:Indenes | 10.1002/med.2610070302 | [] | false | eng | Med Res Rev | 8103150 | 0198-6325 | United States | [] | "2024-08-13T08:46:10.488453Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[First aid and ambulances--some historical observations]. | 84(30-31) | 2429-33 | Lakartidningen | [
{
"affiliation": "",
"forename": "P E",
"identifier": "",
"initials": "PE",
"lastname": "Wiklund"
}
] | 1987-07-22 | 3306226 | D000552:Ambulances / Q000266:history*; D005392:First Aid; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D049691:History, Medieval | D016456:Historical Article; D016428:Journal Article | [] | false | swe | Första hjälpen och ambulanssjukvård--några historiska notiser. | Lakartidningen | 0027707 | 0023-7205 | Sweden | [] | "2024-08-13T08:46:10.489174Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||||
[Diagnosis of peritoneovenous shunt occlusion]. | 371(1) | 39-48 | Reaccumulation of ascitic fluid after peritoneovenous shunt implantation demands accurate diagnostic procedure. Between 1973 and 1985 81 peritoneovenous shunts have been implanted at the IInd Surgical Department of the University of Vienna. In the same time 34 reoperations in 17 patients have been performed for reasons of shunt-dysfunction. Besides thorax x-ray, diagnosis was established in 11 cases by means of Doppler ultrasound investigation, in 26 cases by technetium scan and in 15 cases by shunt angiography. Shuntography proved to be the method of choice, with no false results. Doppler ultrasound results were unclear in a high percentage, thus this method is not used any more. | Langenbecks Archiv fur Chirurgie | [
{
"affiliation": "",
"forename": "W",
"identifier": "",
"initials": "W",
"lastname": "Klepetko"
},
{
"affiliation": "",
"forename": "J",
"identifier": "",
"initials": "J",
"lastname": "Miholic"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Müller"
},
{
"affiliation": "",
"forename": "M R",
"identifier": "",
"initials": "MR",
"lastname": "Müller"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Schwarz"
},
{
"affiliation": "",
"forename": "P",
"identifier": "",
"initials": "P",
"lastname": "Möschl"
}
] | 1987 | 3306227 | D001201:Ascites / Q000601:surgery*; D005260:Female; D006083:Graft Occlusion, Vascular / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010536:Peritoneovenous Shunt; D011183:Postoperative Complications / Q000175:diagnosis* / Q000601:surgery; D012086:Reoperation; D014463:Ultrasonography | D004740:English Abstract; D016428:Journal Article | 10.1007/BF01259242 | [
{
"citation": "Ann Surg. 1977 Feb;185(2):145-6",
"pmid": "836087"
},
{
"citation": "Arch Surg. 1981 Apr;116(4):435-7",
"pmid": "7213000"
},
{
"citation": "Ann Surg. 1984 Aug;200(2):212-23",
"pmid": "6465977"
},
{
"citation": "J Nucl Med. 1983 Apr;24(4):302-7",
"pmid": "6220137"
},
{
"citation": "Surgery. 1980 Jan;87(1):106-8",
"pmid": "7350714"
},
{
"citation": "Ann Surg. 1974 Oct;180(4):580-91",
"pmid": "4415019"
},
{
"citation": "Rofo. 1983 Mar;138(3):288-91",
"pmid": "6403421"
},
{
"citation": "Gastroenterology. 1981 Dec;81(6):1137-9",
"pmid": "7026346"
},
{
"citation": "Surg Gynecol Obstet. 1977 Nov;145(5):745",
"pmid": "910219"
},
{
"citation": "Acta Med Austriaca. 1979;6(4):133-5",
"pmid": "552775"
},
{
"citation": "Surg Gynecol Obstet. 1979 Jan;148(1):93-4",
"pmid": "758707"
},
{
"citation": "JAMA. 1979 Oct 12;242(15):1655-6",
"pmid": "384034"
}
] | false | ger | Diagnostik des peritoneovenösen Shuntverschlusses. | Langenbecks Arch Chir | 0204167 | 0023-8236 | Germany | [] | "2024-08-13T08:46:10.490407Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
[Problems in the reconstruction of bile flow in orthotopic liver transplantation]. | 371(1) | 49-58 | In hepatic transplantation complications of the biliary drainage were frequently observed. Ischemia of the extrahepatic bile duct which occurs for anatomical reasons can cause necrosis of the bile duct. The reconstruction of biliary drainage by biliodigestive anastomosis results in ascending infections of the graft. Biliary sludge could obstruct the intra- or extrahepatic bile duct. Recently, operation methods are mainly applied in which the function of Oddi's sphincter is preserved, i.e. choledocho-choledochostomy or gallbladder conduit method. If it is not possible to perform these methods the Roux-y-jejunum loop is used. Finally, an immediate operative revision of the biliary drainage is indicated if its complication is diagnosed. | Langenbecks Archiv fur Chirurgie | [
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Höfer"
},
{
"affiliation": "",
"forename": "C",
"identifier": "",
"initials": "C",
"lastname": "Höhnke"
},
{
"affiliation": "",
"forename": "K S",
"identifier": "",
"initials": "KS",
"lastname": "Lee"
},
{
"affiliation": "",
"forename": "T S",
"identifier": "",
"initials": "TS",
"lastname": "Lie"
}
] | 1987 | 3306228 | D001652:Bile Ducts / Q000601:surgery*; D003135:Common Bile Duct / Q000601:surgery; D006084:Graft Rejection; D006499:Hepatic Artery / Q000601:surgery; D006801:Humans; D007511:Ischemia / Q000473:pathology; D007583:Jejunum / Q000601:surgery; D008099:Liver / Q000098:blood supply / Q000473:pathology; D016031:Liver Transplantation; D011183:Postoperative Complications / Q000473:pathology | D004740:English Abstract; D016428:Journal Article | 10.1007/BF01259243 | [
{
"citation": "Hepatology. 1984 Jan-Feb;4(1 Suppl):56S-60S",
"pmid": "6319265"
},
{
"citation": "Ann Surg. 1977 Sep;186(3):282-90",
"pmid": "329780"
},
{
"citation": "Surgery. 1972 Oct;72(4):604-10",
"pmid": "4341571"
},
{
"citation": "Arch Surg. 1976 Dec;111(12):1337-47",
"pmid": "793568"
},
{
"citation": "Dtsch Med Wochenschr. 1987 Feb 20;112(8):297-301",
"pmid": "3028750"
},
{
"citation": "Transplantation. 1975 May;19(5):382-7",
"pmid": "168674"
},
{
"citation": "Transplant Proc. 1979 Mar;11(1):262-6",
"pmid": "377641"
},
{
"citation": "Transplant Proc. 1974 Dec;6(4 Suppl 1):129-39",
"pmid": "4373884"
},
{
"citation": "Surg Gynecol Obstet. 1976 Apr;142(4):487-505",
"pmid": "176741"
},
{
"citation": "Surgery. 1977 Feb;81(2):212-21",
"pmid": "319551"
},
{
"citation": "Transplant Proc. 1977 Mar;9(1):309-12",
"pmid": "325773"
},
{
"citation": "Transplant Proc. 1984 Oct;16(5):1228-9",
"pmid": "6385383"
},
{
"citation": "Res Exp Med (Berl). 1982;180(3):239-45",
"pmid": "6750729"
},
{
"citation": "Surg Gynecol Obstet. 1985 Jan;160(1):33-6",
"pmid": "3880618"
},
{
"citation": "Ann Surg. 1976 Nov;184(5):605-9",
"pmid": "791164"
},
{
"citation": "Hepatology. 1984 Jan-Feb;4(1 Suppl):50S-55S",
"pmid": "6363259"
},
{
"citation": "Surg Gynecol Obstet. 1963 Jul;117:47-55",
"pmid": "13941474"
}
] | false | ger | Probleme der Rekonstruktion des Gallenabflusses bei der orthotopen Lebertransplantation. | Langenbecks Arch Chir | 0204167 | 0023-8236 | Germany | [] | "2024-08-13T08:46:10.492790Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
||||
[Role of the lateral nasal wall in the pathogenesis, diagnosis and therapy of recurrent and chronic rhinosinusitis]. | 66(6) | 293-9 | In the vast majority of cases infections of the paranasal sinus system are rhinogenic. Usually these spread via the middle nasal meatus and the anterior ethmoid to the dependent larger sinuses, especially to the frontal and/or maxillary sinus. If a sinusitis does not heal or is constantly recurring, a focus of infection has remained in a stenotic cleft of the lateral nasal wall, irritating nasal function and where from infection time and again may spread to the dependent sinuses. These Infection foci may be very circumscribed and limited, and not always must present with the typical triad of sinusitis symptoms: pathological secretion, nasal obstruction and cephalgia. Frequently only one of these symptoms prevails. By the means of nasal endoscopy and polytomography these foci can exactly be localized. After clearing the infection foci, which easily can be achieved under endoscopic guidance, mucosal function usually is restored and the dependent larger sinuses heal without having been touched. | Laryngologie, Rhinologie, Otologie | [
{
"affiliation": "",
"forename": "W",
"identifier": "",
"initials": "W",
"lastname": "Messerklinger"
}
] | 1987-06 | 3306229 | D002908:Chronic Disease; D006801:Humans; D009296:Nasal Cavity / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D012008:Recurrence; D012220:Rhinitis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D012852:Sinusitis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D014420:Turbinates / Q000000981:diagnostic imaging / Q000473:pathology | D016428:Journal Article; D016454:Review | [] | false | ger | Die Rolle der lateralen Nasenwand in der Pathogenese, Diagnose und Therapie der rezidivierenden und chronischen Rhinosinusitis. | Laryngol Rhinol Otol (Stuttg) | 7513628 | 0340-1588 | Germany | [] | "2024-08-13T08:46:10.493662Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
|||||
[Immunohistological demonstration of the intermediate filaments in a laryngeal carcinosarcoma: considerations on its histogenesis]. | 66(6) | 307-10 | A carcinosarcoma of the larynx was analysed by means of a light microscope and by immunohistological staining technique using antibodies against various intermediate filament proteins. Whereas tumour areas of an epithelial character reacted with antibodies against keratin, the spindle cells demonstrated a positive immunofluorescence with vimentin antibodies. Inside some tumour cells a coexpression of keratin and vimentin (intermediate filaments of mesenchymal cells) could be demonstrated. It is likely that these double stained cells represent the primitive stem cell of the carcinosarcoma, differentiating during further development either into epithelial or mesenchymal tumour cells. | Laryngologie, Rhinologie, Otologie | [
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Vollrath"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Osborn"
},
{
"affiliation": "",
"forename": "M",
"identifier": "",
"initials": "M",
"lastname": "Altmannsberger"
}
] | 1987-06 | 3306230 | D002296:Carcinosarcoma / Q000209:etiology / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D006801:Humans; D007381:Intermediate Filament Proteins / Q000276:immunology; D007382:Intermediate Filaments / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000209:etiology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged | D002363:Case Reports; D004740:English Abstract; D016428:Journal Article | D007381:Intermediate Filament Proteins | [] | false | ger | Immunhistologische Darstellung der Intermediärfilamente in einem Karzinosarkom des Larynx: Uberlegungen zur Histogenese. | Laryngol Rhinol Otol (Stuttg) | 7513628 | 0340-1588 | Germany | [] | "2024-08-13T08:46:10.494558Z" | https://ftp.ncbi.nlm.nih.gov/pubmed/baseline/pubmed24n0110.xml.gz |
Subsets and Splits