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Adjacency evolution. The evolution of an adjacency within a dated species tree, along reconciled gene phylogenies. The gene trees are blue and purple, while red horizontal edges are adjacencies. The time slices t0, ..., t3 indicate in which order the speciation nodes (big green nodes) occur, and are used to localize genes in the species tree (a branch and a time slice give the coordinates of a gene or an event). Red crosses mean gene losses, for example in the branches leading to A or C (adjacencies are lost when one extremity is lost), or an adjacency breakage, for example in the branch leading to D (gene loss and adjacency breakages are different events, since a gene loss is not a rearrangement while a breakage is, and only rearrangements are counted in the objective function). Here one adjacency is gained in the branch leading to species C, one is broken in the branch leading to species D, and one is transferred from the branch leading to B to the branch leading to C. The transfer implies first a speciation outside the species phylogeny, and then a transfer which can be in another time slice. A tandem duplication in the branch leading to A gives a new adjacency between the two copies.	PMC3851846_1471-2105-14-S15-S4-1	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Effect of imprinting temperature on formation of nanoporous (left); (a) 120℃, (b) 140 ℃, (c) 160 ℃, (d) 140 ℃, and (e) PS1/PVA melt droplets on AAO surfaces (right).	PMC6630784_polymers-11-01039-g007	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
SEM micrographs of (A,B) Z, (C,D) PG, and (E,F) ZPG adsorbents.	PMC8548541_41598_2021_25_Fig1_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
SEM images of the glass surface coated in aqueous anatase (TiO2) solution at pH 2 under vigorous stirring for 80 min (×90000). (a) Point EDS analysis of the glass surface. (b).	PMC6526232_gr8	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
PRISMA flow diagram outlining the selection process.	PMC7727811_ijerph-17-08741-g001	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Concatenated mitochondrial cox1 and nuclear 28S genes phylogeny. Araneusbonali sp. n. underlined in green within the Holartic Araneus sequences available at GenBank or BOLD (accession codes shown in Table 3). The red-coloured frame shows the clade corresponding to the Araneusdiadematus group. Tree topology was inferred using Bayesian inference analysis (GTR + I + Gamma substitution model).	PMC6092472_zookeys-779-119-g008	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
TEM structure of the experimental alloy after solution treatment and aging (150 °C, 6 h): (a) dark field, (b) high resolution image, and (c) selected area diffraction patterns (SADP) taken along the [−231] Al zone axis.	PMC9862042_materials-16-00677-g011	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
SEM micrograph of Hydrogum 5 alginate impression material; original magnification 1.200x.	PMC4131559_BMRI2014-178064p008	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Optical microscope images of the cross-section of the glass–ceramics Ba(0) (a), Ba(10) (b), Ba(25) (c) and Ba(50) (d) after thermal treatment of 2 h at 900 °C.	PMC8401496_materials-14-04648-g015	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Schematic representation of the experimental setup for ventilating the target segment and measuring the pressure in the airway. The 12-Fr cuffed endotracheal tube attached to the mechanical ventilator was inserted into the six segmental bronchi sequentially to ventilate the target segment and the cuff was inflated to ensure air tightness (At this point, the endotracheal tube was inserted into the R1a bronchus).	PMC9760698_fbioe-10-1052535-g002	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Representative light microscopic images of DPSCs grown on polydimethylsiloxane (PDMS) substrates with different elasticities (1.5 kPa, 15 kPa, and 28 kPa, respectively, for 1, 2, and 3 days each). (a,d,g) On 1.5 kPa substrates, DPSCs show round, polygonal cell shapes with only short branching as indicated by the inset in (a). (b,e,h) A higher substrate stiffness of 15 kPa leads to a different cell phenotype, i.e., star-like shaped DPSCs with intermediate branching as represented by the inset in picture (b). (c,f,i) Of interest, the highest substrate stiffness, i.e., 28 kPa, leads to a spindle-shaped morphology of DPSCs with long extensions (see also inset in picture (c)). Scale bars represent 50 µm.	PMC10045720_bioengineering-10-00323-g001	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Photographs of AgNWs films prepared by three different methods: (a) drop-casting method; (b) spin-coating method; (c) spray-coating method.	PMC8697850_d1ra00427a-f2	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Study design. Samples from control, steatotic, and Ex-4 treated cells were collected to extract total RNA, including miRNA. The matrix for the NanoString technology was produced. Many bioinformatics tools were employed to analyze and display the collected data.	PMC10380891_ijms-24-11606-g001	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Nanoparticles size characterization by Scanning Electron Microscopy (SEM). (a,b) show images of unloaded hybrid Inulin–Soy Protein nanoparticles (NBs). (d,e) show hybrid Inulin–Soy Protein nanoparticles loaded with flavonoids ((-)-Epicatechin and Quercetin) (NEQs). (c,f) show average particle size distribution histograms for NBs and NEQs.	PMC10223423_nanomaterials-13-01615-g001	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Schematic representation of horizontal cross-sections of the root.	PMC9321937_materials-15-04966-g001	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Application of the PDMS/PAFAB wrinkling system for rewritable information storage as a result of selective exposure to visible light: as-fabricated wrinkle-forming surface (a); various patterns of wrinkles obtained by selective exposure via different photomasks (b–d).	PMC9048581_c9ra10569g-f6	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Genes displaying correlation with nucleolin expression in PCa. Correlation data between NCL expression measured by HTA2.0 array and (a) HSPD1, (b) PA2G4, (c) SERBP1, (d) PAICS, (e) GART, (f) CCT5, (g) NPM1, and (h) CSP1. Hierarchical cluster analysis and a heatmap were generated using NCL expression, as assessed by mRNA expression. In the heatmap, each column represents a gene, and each row represents a patient (i).	PMC9101690_ijms-23-04491-g004	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Characterization of SOA-R mosquitoes and computational modelling for the spread of SOA.(a) Bar plot showing Yob mRNA levels relative to Rp49 in WT and homozygous SOA-R pupae measured by RT-qPCR. Yob mRNA levels confirm the sex of the pupae used in Fig. 5b. The height of the bar plot is the mean of n = 4 biological replicates with overlaid individual data points. (b) Representative pictures of SOA immunostaining (orange), RNA Polymerase 2 immunostaining (grey) and co-RNA FISH (green) of a X-linked transcription site (AGAP000651) on salivary gland nuclei of a homozygous male SOA-R L4 larva. The RNA-FISH probes were designed against the introns of the AGAP000651 gene. DAPI is shown in blue, scale bar = 10 μm. (c) Representative pictures of SOA immunostaining conducted on homozygous SOA-R male and female adult mosquito tissues. Pictures show nuclei of Malpighian tubules (left, scale bar = 5 μm) or gut (right, scale bar = 10 μm) with SOA in orange and DAPI in blue. The pictures represent a 3D view of a z-stack. Further images in Fig. 5c. (d) Pearson correlation clustering of SOA CUT&Tag samples based on affinity scores after peak calling. The experiment was conducted with SOA antibody and IgG in WT and homozygous SOA-R female pupae. The SOA antibody data was filtered using the IgG control and then subjected to clustering. (e) Heatmap showing the normalized CUT&Tag coverage on all significant peaks (FDR<0.05, fold-change >0) in SOA-R in comparison with WT female pupae. The mean enrichment is shown as a metaplot on top (n = 2 biological replicates, merged for visualization). (f) Genome browser snapshot of the SOA CUT&Tag enrichment obtained in SOA-R females in comparison with WT males on a representative region of the X-chromosome. Duplicate reads were filtered out and the replicates were merged for visualization. (g) CUT&Tag as in (e) Metaplot showing the mean CUT&Tag enrichment on expressed X-linked genes (≥10 average read counts), which were further grouped by unsupervised k-means clustering in 3 groups with strong, medium and weak SOA binding strength. The coverage was calculated using the TSS as a reference point with 1 kb upstream and the gene bodies downstream scaled to 5 kb. The replicates were merged for visualization. (h) Violin plot with center line representing the median RNA expression in log2 TPM (transcripts per million) from RNA-seq of WT females for each of the 3 clusters (based on binding in SOA-R, see (g)). p-value: two-sided Wilcoxon rank-sum comparing combined clusters 1 and 2 versus cluster 3. (i) Euclidean distance heatmap obtained by DESeq2 representing the similarity of the samples in RNA-seq conducted from WT (n = 3 biological replicates) and homozygous SOA-R (n = 4 biological replicates) female pupae. (j) RNA-seq as in (i) Violin plots showing the log2FC on expressed X-linked genes (≥10 average read counts), which were further grouped by unsupervised k-means clustering in 3 groups with strong, medium and weak SOA binding strength, see (g). The center line represents the median log2FC, which equals 0.613, 0.355, and 0.117 (strong, intermediate and weak binding) and corresponds to fold changes of 1.529, 1.279, and 1.084, respectively. (k) RNA-seq as in (j) but plotting the log2FC for all genes according to the chromosomal location in WT compared to homozygous SOA-R pupae as a violin plot. Each gene with an average read count (baseMean) > 0 was taken into account, irrespective of whether it was scored as DE or not. The Bonferroni-corrected p-value was obtained with a two-sided Wilcoxon rank-sum test comparing X with all autosomes. The center line represents the median (also see Supplementary Table 3). (l) RNA-seq as in (i) but plotting the log2FC distribution of autosomal (grey) and X-linked genes. The X-linked genes were split into two groups based on SOA binding in CUT&Tag (Supplementary Table 2). The yellow violin plot shows X chromosomal genes without SOA peaks, the blue violin plot shows peaks that were scored as differentially bound by DiffBind (SOA-R versus WT females, FDR<0.05, fold>0). Median log2FC values for each group are available in Supplementary Table 3. The Bonferroni-corrected p-values obtained with a two-sided Wilcoxon rank-sum test comparing all groups between each other are: autosomal versus X-linked genes without SOA peak p = 6.57E-12; autosomal versus X-linked genes with SOA peak p = 1.45E-44; X-linked genes without versus with SOA peak p = 5.48E-06. (m) A single culture of SOA-R (males + females) was conducted in parallel to WT males (T4 strain), cultured separately. For both, the developmental timing of each of the 3 genotypes was scored by counting the appearance of pupae. Pupa appearance is represented as a cumulative distribution with dots representing a given time-point when pupa numbers were scored. The t = 0 on the x-axis represents the time when the first pupa appeared in the culture. The data represents one experiment. For comparison, the mean WT male and female pupation timings scored in Fig. 4f (exp 1-2022) are plotted in the panel. A separate experiment with additional n = 3 independent replicate cultures for SOA-R grown together with WT is presented in Fig. 5g. (n) Checkerboard plot indicating the relative frequency of SOA+/SOA+ males (colour-coded) after 10,000 generations of selection depending on the selection coefficients sm in males (x-axis) and sf in females (y-axis). Fitness is normalized to 1 in SOA−/SOA− males and females. Moreover, we assume that SOA+ is dominant over SOA− in males and recessive in females. Hence, the fitness of SOA+ bearing males is 1 + sm, while the fitness of SOA+/SOA+ females is 1- sf. Even if selection against SOA+ in females is stronger than selection in favour of SOA+ in males, SOA+ is, for most parameter combinations, maintained in the population at considerable frequencies.	PMC10620080_41586_2023_6641_Fig15_ESM	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Whole‐brain analyses show positive and inverse relationships between self‐reported navigation ability and optic flow‐sensitive region functional connectivity strength during turn counting. Effect maps (left and top right) and summary map (bottom right) showing where the functional connectivity patterns of OF‐sensitive regions during TC were positively and inversely associated with SBSoD score (Z threshold 2.3). Warm colors represent a positive association; (top) stronger connectivity between OF‐sensitive regions (L CSv, R CSv) and warm‐colored areas during TC relative to rest was associated with better self‐reported navigation ability (higher SBSoD scores). (bottom right) The maximum overlap of where OF‐sensitive region functional connectivity was positively associated with SBSoD score was 2, which can be seen in a number of areas in the summary map. Blue regions represent the inverse association found; (bottom) stronger connectivity between the OF‐sensitive region R pVIP and cool‐colored areas during TC relative to rest was associated with worse self‐reported navigation ability (lower SBSoD scores). Maps are displayed on the MNI152 T1 2 mm template, and x, y, and z slices correspond to this template. For more detailed information on the strength and statistical significance of the relationships shown in these figures, see Table 3. FC: functional connectivity; Hipp: hippocampus; L: left; L CSv: left cingulate sulcus visual area; MNI: Montreal Neurological Institute; OF: optic flow; R: right; R CSv: right cingulate sulcus visual area; ROI: region of interest; RSC: retrosplenial cortex; SBSoD: Santa Barbara Sense of Direction; TC: turn counting	PMC6456774_BRB3-9-e01236-g005	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Potential mechanisms of DS in ameliorating the neurocognitive dysfunction induced by simulated long-duration spaceflight in rats. The effects of SLSE were indicated in blue, and those of DS were indicated in red. DS regulated neurotransmitter content changed by simulated long-duration spaceflight. Neurotransmitters mediate intracellular signaling transduction systems through receptors, thus regulate learning and memory. By activating the PI3K-Akt-mTOR pathways and increasing CREB phosphorylation and expression of BDNF, DS promoted the plasticity-related proteins expression. By inhibiting the phosphorylation level of JNK and p38, DS inhibited neuronal apoptosis. DS ameliorate neurocognitive functional impairment induced by simulated long-duration spaceflight.	PMC5446991_fphar-08-00315-g007	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
BIBW2992对于NCI-H1975裸小鼠移植瘤的生长抑制作用Inhibitory effect of BIBW2992 on transplanted NCI-1975 in nude mice	PMC6000415_zgfazz-17-12-834-1	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
NetworkDB conceptual model. In this entity-relationship schema, entities are in boxes and relationships in ellipses.	PMC3710241_1471-2105-14-207-2	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
(A) The depth-projected vasculature within the first 2 mm of mouse brain bearing a xenotransplanted U87 human glioblastoma multiforme tumor imaged with OFDI. Depth is denoted by color: yellow (superficial) to red (deep). Scale bar, 500 μm. Right panels: Validation of the morphological measurements obtained from OFDI and MPM. (B,C) Normal brain vasculature acquired by OFDI (B) and MPM (C). The automated vascular tracing was applied to registered vascular data sets to quantify the resolution of OFDI angiography and (D) validation of the morphological measurements obtained from OFDI. Scale bars, 250 μm. Adapted with permission from Vakoc et al. (2009).	PMC5006088_fncom-10-00082-g0003	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Schematic presentation of the three classes of Ng-compounds discussed in this article.	PMC6719121_molecules-24-02933-g002	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
2nd case. CT - sagittal plan of a large retroperitoneal hematoma - 17.76 cm.	PMC2992055_1749-8090-5-108-2	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Mitochondrial content is reduced in axons of ADOA RGCs.a Representative z-projections of stacks of confocal images of mtRFP (red) in primary RGCs co-transfected with the indicated plasmids and after 24 h fixed and immunostained with β-tubulin III (βtub III, grey). Axons and somas were magnified in the bottom panels. EV, empty vector. Bars, 20 μm. b Quantification of mitochondrial length from four independent experiments as in (a) (EV, n = 86; Opa1, n = 113; Opa1K301A, n = 82; Opa1R905, n = 71; Opa1Q297V, n = 114 cells). **p < 0.0001 vs. EV in one-way ANOVA/Tukey’s test. c Quantification of mitochondrial content in axons from four independent experiments as in (a) (EV, n = 58; Opa1, n = 65; Opa1K301A, n = 69; Opa1R905, n = 54; Opa1Q297V, n = 64 cells). p = 0.018 Opa1, p = 0.027 Opa1Q297V vs. EV; **p < 0.0001 vs. EV in one-way ANOVA/Bonferroni’s test. d Representative z-projections of stacks of confocal images acquired 24 h after transfection of primary RGCs co-transfected with mtRFP (red) and YFP-LC3 (green, autophagosome-LC3, auto-LC3) and the indicated plasmids. The cytoplasmic YFP-LC3 signal (cyto-LC3) is pseudocolored in grey for the sake of clarity. The region corresponding to the soma was magnified in the inset. Bars, 20 μm. e Quantification of soma mitochondria and autophagosome distribution towards the axonal hillock in 4 independent experiments as in (d) (EV, n = 65 mitochondria and 49 autophagosomes; Opa1, n = 69 mitochondria and autophagosomes; Opa1K301A, n = 58 mitochondria and 47 autophagosomes; Opa1R905, n = 69 mitochondria and autophagosomes; Opa1Q297V, n = 70 mitochondria and autophagosomes) *p = 0.0023 Opa1K301A vs. EV; p = 0.0084 Opa1R905 vs. EV; ***p < 0.0001 vs. EV in one-way ANOVA/Tukey’s test. f Quantification of mitochondria and autophagosome co-localization in six independent experiments as in (d). (EV, n = 86; Opa1, n = 86; Opa1K301A, n = 101; Opa1R905, n = 82; Opa1Q297V, n = 91 cells). p = 0.0153 Opa1K301A, p = 0.043 Opa1R905 vs. EV in one-way ANOVA/Tukey’s test. In box plots, centre line represents mean, bounds of boxes SEM, whiskers the 10th–90th percentiles; each dot represents independent experiments. Source data are provided as a Source Data file.	PMC7423926_41467_2020_17821_Fig1_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Patient pathway.	PMC10864516_fmed-10-1255798-g001	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
a Superior view of the anterior skull base. Bilateral olfactory nerves have been severed 10–15 mm from the skull base. b The cut edges of the olfactory nerve are clipped and connected to a light, small rubber bag by a monofilament string. Whole view (c) and schematic drawing view (d) of this study. The angle of pulling of the olfactory nerve from the frontal skull base and from the axis of the olfactory nerve is regulated by pulling. The olfactory nerve was pulled by a rubber bag through a string during which water was poured into the bag at 1 ml per 10 s until the nerve was pulled out from the cribriform plate	PMC3442168_10143_2012_378_Fig2_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Abduction defect of the left eye.	PMC10123313_CCR3-11-e7268-g003	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
CT control scan of VB (sagittal)	PMC5086345_381_2016_3250_Fig7_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
ER and actin filaments interaction during plasmolysis in Arabidopsis. A) Actin formation at different focal planes (lower left) of a plasmolyzed hypocotyl cell with a 3D reconstruction showing several Hechtian strands, one of which is labeled HS. Regions containing the Hechtian reticulum as identified with DIC are shown as HR. B–D) Confocal images of hypocotyl cells showing the separate green channel with actin filaments labeled with YFP-ABD2, the red channel showing the ER labeled with mCherry-HDEL, and a merged image. B) ER tracks on actin within the protoplast during plasmolysis. The outline of the protoplast is in cyan. C) Actin doesn’t show up in the Hechtian reticulum outlined in cyan. D) Actin forms a big Hechtian strand within the periplasmic region, labeled HS, but is excluded in the fine network of the Hechtian reticulum, labelled HR. Adj. cell, adjacent cell. Scale bar, 10 μm.	PMC5853952_erx24307	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Schematic illustrating the major findings of this study.	PMC11219778_41421_2024_693_Fig7_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Cathodoluminescence microtextures and O isotopic analyses of A.Vaq, B.Vcpq, and D. Vmqp veins. (a) A A.Vhq vein was crosscut by a B.Vcpq vein in a chlorite-sericite altered porphyry. Qz1 and Qz2 had uniform δ18O values (9–10‰), whereas Qz4 had high values (up to 20‰) (the vein photographs and CL image were adapted from Liu et al.26); (b) A D.Vcpq vein hosted in chlorite-sericite porphyry. Qz2 was overprinted by Qz3, Qz5, and Qz6. Qz3 and Qz5 had slightly higher δ18O values (11–12‰), whereas Qz6 has much higher values (ca. 17‰). The ellipses were the analytical spots accompanied with spot numbers. The figure was reproduced using CorelDRAW2019 (http://www.coreldraw.com/en/).	PMC11303379_41598_2024_52978_Fig2_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Stress analysis of the infinite center-cracked steel plate strengthened with FRP plates.	PMC6068973_sensors-18-02356-g003	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Characterization of tumors and PDX models Clinical and pathological features of breast tumors used in the study. Numb status was evaluated by IHC (see Materials and Methods). Tumor grade: G3, high; G2, intermediate. HER2 status was evaluated by IHC and confirmed by FISH (positive, POS; negative, NEG). Estrogen receptor (ER) and progesterone receptor (PR) status were evaluated by IHC and are reported as the percentage of positive cells. p53 wild‐type (WT) status was established by sequencing of the p53 coding sequence (see Materials and Methods).MSs derived from two Numb− (T1 and T2) and two Numb+ (T3 and T4) tumors were treated in vitro with the proteasome inhibitor MG132 (0.5 μM for 48 h) and analyzed by IB as indicated. The increase in β‐catenin was used as a control for the efficacy of proteasome inhibition by MG132. GRP94, loading control. Data for the other tumors (T3, T4, TC, TD) are in Appendix Fig S1A.Top: Representative images of Numb IHC staining (brown) of hematoxylin–eosin counterstained FFPE sections from Numb− (T1 and T2) and Numb+ (TA and TB) human primary BCs. Scale bar = 30 μm. Bottom: The four primary BCs were orthotopically xenografted into NGS mice, and the resulting PDXs were stained as in the top panel. Scale bar = 30 μm. Data for the other primary tumors (T3, T4, TC, TD) and corresponding PDXs are in Appendix Fig S1B.Sphere forming efficiency (SFE) at passage 2 of the indicated MECs: N1 and T1, normal and tumor MECs from patient 1 (Numb−); N2 and T2, normal and tumor MECs from patient 2 (Numb−); TA and TB, tumor MECs form patients A and B (Numb+). For each tumor, data are expressed as the mean of four independent experiments (± SD of 12 measurements).A typical serial propagation experiment with MSs obtained from MECs as in (D). The cumulative sphere number over four passages is reported. See also Appendix Fig S1D for a detailed description of the serial propagation assay exemplified using N1 and T1 samples. Shown data are from experiments representative of three biological replicas and are expressed as the mean value of technical triplicates. When not indicated, SD was < 30% of the mean. Data for the other tumors (T3, T4, TC, TD) are in Appendix Fig S1E.	PMC5412856_EMMM-9-655-g002	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Vacuum DC surface flashover voltage measurement system.	PMC9460208_polymers-14-03605-g002	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
SEM micrographs after Rockwell C indentations with a load of 150 kgf on different coated surfaces (a) AlCrN; (b) AlTiN/Si3N4; and (c) AlCrN/Si3N4.	PMC5872937_materials-11-00358-g005	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Effect of GDF6 treatment on the mesenchymal lineage commitment of H1 hESCs. a qRT-PCR analysis of the expression of mesodermal genes (FOXF1, MSX1, TBXT, KDR, GATA4) in H1 hESCs treated with 300 ng·mL−1 GDF6. b qRT-PCR analysis of the expression of MSC surface markers (CD73, CD146, and CD271) in H1 hESCs treated with 300 ng·mL−1 GDF6. c Flow cytometry analysis of CD73, CD146, and CD271 expression in vehicle- and GDF6-treated H1 cells. d ALP staining and quantitative ALP activity assay after 14 days of osteogenic induction (OI) for vehicle- or GDF6-treated H1 cells. e ARS staining and quantification after 14 days of OI for vehicle- or GDF6-treated H1 cells. f Alcian blue staining and quantification after 21 days of chondrogenic induction (CI) for vehicle- or GDF6-treated H1 cells. qRT-PCR gene expression analysis of osteogenic markers (ALPL, RUNX2, IBSP, OCN) (g) and chondrogenic markers (SOX9 and COL2a1) (h) after lineage-specific differentiation of H1 cells cultured in the presence or absence of GDF6. All in vitro experiments were performed three times independently. P < 0.05, P < 0.01, **P < 0.001. For a–f, Student’s t test; for g and h, two-way ANOVA with Tukey’s post hoc test	PMC7672114_41413_2020_116_Fig2_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Versican and ALP expression in the presence of soluble factors. Versican: immunocytochemistry, fluorescent microscopy, scale bare 200 μm. ALP: histochemistry, bright field microscopy, scale bare 500 μm.	PMC5654293_SCI2017-9271869p006	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Temporal sequence of host immune responses to allogeneic islets, including instant blood mediated inflammatory reaction (IBMIR), inflammation, innate response, and allo‐rejection, the response time of which can range from hours to years following transplantation.	PMC8425879_ADVS-8-2003708-g009	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Scanning electron microscope (SEM) images of Ag-AuNPs/RGO magnified 1500 times (A); and 33,000 times (B).	PMC6071074_nanomaterials-08-00507-g001	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Immunocytological staining of IPEC‐J2 cells on filter membranes with antibodies raised against ZO‐1 (green) and claudin‐1 (red) after 24 h of incubation with berberine. Nuclei were stained with DAPI (blue). Under control conditions, both proteins were detected in the lateral membrane; the yellow signal in the overlay shows co‐localization. The signal for ZO‐1 was also located next to cell‐cell contacts for all concentrations, while the signal for claudin‐1 was detected more intracellularly than in the TJs of the 100 µM and the 200 µM groups. In addition, the ZO‐1 signal appears weaker with increasing berberine concentrations. The area circled by white dots shows a hole inside of the monolayer (scale bar: 20 µM, n = 4, representative images)	PMC8981188_PHY2-10-e15237-g007	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
The dynamics of pharmacological response mechanisms can be examined by analyzing integrated multiomics data. First, the time series of the multiomics data are integrated. Second, an efficient module-detecting algorithm is applied to the composite maps. The maps can then be used for comparing cancer cells and normal cells and for assessing the effects of medicines. Lastly, the identified targets can be validated in animal experiments designed for the purpose of subsequent drug development.	PMC4306365_BMRI2015-104209p001	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Spaghetti plot for the 15 patients in whom serum Mg concentrations were available at all three time points (i.e. before HCC diagnosis, at tumor diagnosis and after locoregional treatment). The dotted lines represent patients in whom the serum Mg concentration decreased at the diagnosis of HCC compared to before and then increased subsequently after locoregional treatment. Other patients who did not show such temporal changes in serum Mg are represented by the solid lines.	PMC8313704_41598_2021_94509_Fig2_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Scanning electron microscope image of a cover glass surface with the LCLD-synthesized Au nanoparticles under different conditions: (a,b) exposure time—1 min, solution concentration—1 mM; (c) exposure time—5 min, solution concentration—1 mM; (d) exposure time—5 min, solution concentration—5 mM.	PMC7178654_materials-13-01767-g003a	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
A–C Role of FcRn on recycling and degradation of pathogenic IgG antibody levels (A, B) and effect of FcRn heterozygosity (C) on sustainability of infused IVIg. A Normally, IgG antibodies (Y in red) bind to FcRn (light-blue receptors) to return, via the endocytotic vesicles, intact back into the circulation being protected by FcRn from degradation in the lysosomes. B The supra-physiological IgG levels from the infused IVIg (Y in blue) partially saturate the FcRn (saturated receptors depicted in red dots) leading to degradation of the endogenous IgG antibodies in the lysosomes, instead of being recycled back to the surface (degraded Y in red), resulting in reduced circulating IgG antibody levels. C The FcRn in heterozygous VNTR2/3 patients (depicted with red dots on the light-blue FcRn receptors) may not be fully effective in saturating FcRn and protecting the infused IVIg from degradation; as result, part of the infused IgG is degraded in the lysosomes instead of fully returning back into the circulation (degraded Y in blue). In heterozygous VNTR2/3 patients therefore, the IgG serum level from the infused IVIg does not increase as much as in homozygous VNTR3/3 individuals who have fully functioning FcRn, resulting in lower immunomodulatory effect of IVIg and lesser reduction of the pathogenic antibodies; higher IVIg dose to compensate for its catabolism is perhaps needed for the VNTR2/3 heterozygotes (adapted from [37])	PMC8585501_13311_2021_1108_Fig3_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Sagital (a) and coronal oblique (b) MPR views show a severe atheromatous stenosis of a rare CCMT in this 58-year-old women. Transhepatic anastomose is found between the HA and the right IPA (yellow arrow) as illustrated on this elective VR view (c).	PMC5854326_jbsr-101-1-1203-g10	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
(a–c) SEM images of GFs/Cu composites in Z plane as the volume fraction of GFs is 30%, 50% and 70%, respectively; (d–f) Corresponding frequency analysis of β and function fitting of ρ(β).	PMC6981997_materials-13-00046-g005	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Schematic illustration comparing previous works and this work.In this work, we propose a strategy to enhance the utilization of internal excitons by suppressing the recombination of metastable excitons, polarons, and photogenerated charge carriers during interlayer transfer.	PMC11208529_41467_2024_49373_Fig1_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Anatomy of the sympathetic chain in relation to the spinal cord and sweat glands as the target organ 16 .Reprinted from Thoracic Surgery Clinics, Volume 18, Issue 2, Shargall Y, Spratt E, Zeldin RA. Hyperhidrosis: What is it and why does it occur? Pages 125–132, Copyright (2008) with permission from Elsevier.	PMC7338916_f1000research-7-16079-g0000	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
LINC00152 and FSCN1 expression levels are associated with clinicopathological parameters of CRC patients. A) In situ hybridization and immunohistochemistry staining detection of LINC00152 RNAs and FSCN1 proteins in CRC tissue microarray, respectively. Upper: Original magnification, 40×. Scale bar: 200 µm; Lower: original magnification, 200×. Scale bar: 50 µm. B) Expression scores of LINC00152 RNAs and FSCN1 proteins in CRC tissue microarray that was containing 30 cases normal mucosa tissues and 94 CRC tumor tissues. C) Receiver‐operating characteristic (ROC) curves displaying the sensitivity and specificity of LINC00152 or FSCN1 combined with LINC00152 expression for the diagnosis of CRC patients from TCGA data. Insets indicate AUC values, 95% confidence intervals, and statistics. D) Overall survival (OS) according to Kaplan–Meier analysis shows a difference in the survival between CRC patients with overexpression of both LINC00152 and FSCN1 as compared with the lower expression of both transcripts in the GSE17538 dataset. E) Schematic representation of a model for the major molecular mechanisms of “YAP1/LINC00152/miR‐632‐miR‐185‐3p/FSCN1” axis in CRC. ***p < 0.001.	PMC7001651_ADVS-7-1901380-g007	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Transthoracic echocardiogram, 4-chamber view, demonstrates a left atrial mass measuring up to 5 cm in length.	PMC4786083_cureus-0008-000000000484-i01	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Mechanism of kaempferol suppressing proliferation in gynaecological malignancies.	PMC10748757_fphar-14-1310416-g002	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Magnetic resonance imaging of the pygopagus twins; they shared the sacrum, coccyx, anus, and urethra. Each had a separate bladder	PMC7788156_40981_2020_406_Fig1_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Reconstructed 3D subcellular tomography of Candida rugosa. Yellow arrow: cytoplasm, pink arrow: cell wall, violet arrow: nucleus, red arrow: vacuole, green arrow: mitochondria, (visualization 3, visualization 4).	PMC5899089_41598_2018_24408_Fig6_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Minimum spanning tree showing the relationship between 459 MLVA genotypes identified in this study, collected in the database and reported elsewhere with reference to the host species.Only complete MLVA-6 profiles were included in the analysis.	PMC6328121_ponep0210244pg003	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Optical micrograph of the homogenized aluminum alloy 6060, at (a) ×100 and (b) ×500 magnification.	PMC10856554_materials-17-00545-g012	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
(A) SEM image of polychrome accretion sample K11-11 collected in the Drysdale River region, box indicates site of EDS analysis. The image displays the intimate, mixed range of well crystallised minerals. EDS spectra identifies sulphate crystals, however XRD analysis also confirms the presence of oxalate and phosphate minerals including whewellite and newberyite. (B) EDS spectra displaying major peaks at O, S and Ca.	PMC5633166_gr24	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Characterization of Ldh expression in the intestine and Malpighian tubules.The Ldh expression pattern in the intestine and Malphigian tubules of L3 larvae was examined using Ldh-GFPGenomic, Ldh-GFPenhancer, and an αLdh antibody. (A-L) Representative confocal images of Ldh expression and DAPI staining in (A-F) the midgut and (G-L) the Malphigian tubules. Note that Ldh is expressed at significantly higher levels in (A,C,E) a subset of small cells of the AMP clusters (denoted with arrowheads in (A-F)) and (G,I,K) the stellate cells of the Malpighian tubules. For Ldh-GFPGenomic and Ldh-GFPenhancer expression analysis, tissues were fixed and stained with an αGFP antibody as described in the methods. The scale bar in all images represents 40 μM.	PMC10312709_nihpp-2023p06p15p545165v3-f0004	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
(A) Bone scintigraphy (anterior and posterior) demonstrated avid radiotracer uptake in the T11 vertebral body (arrow). (B) Axial CT imaging identified bone destruction at T11 with partial cortical breach and an adjoining paravertebral soft tissue mass that contributed to spinal canal stenosis. (C) Lateral radiograph of the spine demonstrated osteolytic damage and collapse of the T11 vertebral body (arrow). (D–G) 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT showed extensive destruction of the T11 vertebral body (thin arrow) and intense FDG uptake (maximum standardized uptake value of 8.8) in the surrounding soft tissue (thick arrows) [(D), MIP image; (E), CT; (F), PET; and (G), fusion].	PMC10884278_fonc-14-1294772-g002	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
RhoC Is Required for Vaccinia-Induced Cell Contraction(A) Immunoblot analysis of glutathione pull-downs on WR-infected HeLa cell lysates reveals that GST-F11 interacts with GFP-tagged RhoA, RhoC, RhoD, RhoE, and RhoF.(B) Quantification of the area of HeLa cells treated with the indicated siRNA at 3 hr 40 min post infection with WR.(C) Quantification of the area of HeLa cells expressing GFP or GFP-tagged wild-type (WT) or T19N (dominant-negative) RhoC 3 hr 40 min after infection with WR (left) or ΔF11L (right).(D) Images showing the association of GFP-RhoC with the plasma membrane in cells infected with WR for 3 hr 40 min. The time is indicated in seconds and mCherry provides a volume marker (see Movie S4). Scale bar, 5 μm.(E) Quantification of WR-infected HeLa cell area at 3 hr 40 min post infection in the presence or absence of C3, 72 hr after treatment with the indicated siRNA.(F) Normalized cell area of WR-infected HeLa cells at 3 hr 40 min post infection, 72 hr after treatment with the indicated siRNA.Error bars in graphs represent the SEM from three independent experiments, in which a total of 90 (B), 60 (C), and 80 (E and F) cells were analyzed. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001; ns, not significant. See also Figure S4.	PMC5425256_gr4	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Exploiting the p53 Gene Status to Induce Mitotic Catastrophe in p53 Mutant Cells but not in Normal CellsOn the left hand side of the figure labeled A, cells with WT p53 undergo cell cycle arrest upon treatment with Nutlin-3a. However if they are then treated with chemotherapeutic drugs they do not under go mitotic catastrophe. If the chemotherapeutic drug is removed effectively, the normal cells will recover, resume cell cycle progression and grow. On the right hand side of the figure labeled B, in p53 mutant cells, the cells do not undergo cell cycle arrest upon treatment with Nutlin-3a. Then upon treatment with chemotherapeutic drugs, the cycling cells undergo mitotic catastrophe.	PMC3260816_oncotarget-02-109-g001	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Object recognition and localization results for different types of objects: (a) three parts randomly stacked; (b) seven parts randomly stacked and (c) two parts randomly stacked.	PMC6412728_sensors-19-00764-g021	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Schematic diagram of three kinds of fabrics. (a) is a 3D woven fabric; (b) is a 3D braided fabric [20]; (c) is a knitted fabric [21].	PMC8838001_polymers-14-00377-g002a	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
(a) TEM image, (b) thickness distribution, (c) lattice structure and (d) selected area diffraction pattern of GZF25.	PMC6227928_rsos181330-g4	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Morphological analysis at the scanning electron microscope (SEM) of Chlamydomonas sp. cultured in: (a) control condition, salinity 36‰; (b) salinity 20‰; and (c) salinity 70‰.	PMC11355073_marinedrugs-22-00351-g002	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Rho activity is required for the assembly of tangential and radial AJs.Cell monolayers were wounded in the presence of C3 transferase and TRITC-labeled dextran (as a marker). Cells were fixed and stained for E-cadherin or N-cadherin. In control cultures, AJs are formed at the sites of cell-cell contacts (arrows). The IAR-2, IAR-6-1, and IAR1170 cells loaded with C3 are unable to assemble new AJs (arrowheads). Bar, 10 µm.	PMC2779654_ponep0008027pg007	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
HFD effect on BBB integrity in the striatum of sham, moderate, and severe lesion groups. A Confocal images showing plasma protein leakage (green) (fibrinogen left panel and IgG right panel) in sham, moderate, and severe lesion groups fed with either CTRL diet or HFD. B, C Corresponding quantification of extravascular fibrinogen and IgG, respectively. Data are expressed in sqrt % of leakage fraction area of the total image area. Sham (CTRL diet: n = 5, HFD: n = 4), moderate lesion mice (CTRL diet: n = 3, HFD: n = 3), and severe lesion mice (CTRL diet: n = 6, HFD: n = 4). Two-way ANOVA: p < 0.05, *p < 0.01. Scale bar 50 μm. IgG immunoglobulin G	PMC8353816_12974_2021_2218_Fig7_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
SRD5A1 knockdown induces autophagy via PI3K/Akt/mTOR pathway.A The ultrastructure of autophagosome in ARP1- and H929-SRD5A1-KD treated with Dox compared to SRD5A1-KD cells observed by transmission electron microscopy. B The level of autophagosome in (A) was quantified. One-way analysis of variance (ANOVA) was carried out. C Western blotting assay on SQSTM1, ATG-7, ATG-5, and LC3 expression in ARP1- and H929-SRD5A1-KD cells treated with or without Dox. D Immunofluorescence staining of LC3 expression in ARP1- and H929-SRD5A1-KD cells treated with or without Dox. E Western blotting assay on PTEN and Ras expression in ARP1- and H929-SRD5A1-KD cells treated with or without Dox. F Expression of a marker protein in PI3K/Akt/mTOR signaling was detected by western blotting in ARP1 and H929 cells.	PMC7904855_41419_2021_3510_Fig5_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Potential action of anoctamins on exocytosis, growth and microvesicular signaling. ANO1 and ANO6 determine the extent of membrane protrusions and membrane blebbing in macrophages and other cell types, and support cell migration, diapedesis and cancer metastasis. Exosome release and paracrine signaling by epithelial cells is probably anoctamin-dependent. Support of membrane unfolding, cell swelling and subsequent activation of VRAC could be a general property of anoctamins. Mucus secretion and release of inflammatory mediators such as autacoids and cytokines was shown to be ANO1-dependent. Exocytosis leads to enhanced expression of membrane proteins, cell growth, and extensions such as motile cilia and the primary cilium, as proposed for ANO1. For further details and references, see main text.	PMC6468699_cancers-11-00382-g005	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
The Optimized Aggregation of Predictions framework. From a list of candidate thresholds, the one which maximizes the correlation between the predictions made by the trained model on the validation data normalized with reference to its own personal baseline (Prediction*, denoted by blue) and the aggregated binary predictions made by the same model on the validation data standardized using the normalization factors of different training subjects (Majority Vote %, denoted by red) is chosen to be used for converting the prediction scores to binary predictions on the test data.	PMC8839064_sensors-22-01024-g002	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Examples of the concordant groups (A and B) where there is agreement between the visual rating and all three meta-ROIs while the discordant groups (C and D) have disagreement visually and with all three meta-ROIs. While the meta-ROI can miss visually positive scans where the SUVR is lower than the cutoff point (C), the visual assessment does not consider isolated increased activity in the MTL (D). The red arrows indicate where there is increased tracer uptake activity.	PMC10602128_nihpp-rs3290598v1-f0004	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Effect of vitamin E on PTE-induced oxidative stress in cancer cell lines. Cells were treated with or without PTE (10 μM) and/or vitamin E (10 μM) and/or N-acetyl-L-cysteine (NAC) (5 mM) for 48 h. (A) Mitochondrial ROS was assessed by MitoROS (red color). MitoROS image was merged with phase-contrasted image. (B) Cell proliferation was assessed by MTS. (C) Semi-quantification of mitochondrial ROS. C, control; P, PTE; PE, PTE+vitamin E; PN, PTE+NAC. Error bar, standard deviation from three independent examinations. Statistical difference was calculated by ordinary analysis of variance. Scale bar, 25 μm. PTE, pterostilbene; ROS, reactive oxidative species; FI, fluorescence intensity; NAC, N-acetyl-L-cysteine; MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium.	PMC7762551_ijms-21-09347-g005	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Type I myofibers are increased by IH in diaphragm but not limb muscle.(A) Low and high magnification images of Ctl and IH diaphragm sections immunostained for type I myosin heavy chain (MyHCI). (B) Proportion of myofibers expressing type I MyHC in the diaphragm. (C) Quantification of the relative area contribution of type I MyHC-expressing fibers to total tissue cross-sectional area of the diaphragm. (D) Proportion of MyHCI-positive myofibers in the limb muscle. (E) Quantification of the relative area contribution of MyHCI-positive fibers to total tissue cross-sectional area of the limb muscle. Data are expressed as means (± SE) of 5 mice per group. * p<0.01 compared to Ctl by t-test. Scale bar = 100μm.	PMC4480857_ponep0131068pg006	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Analytical framework. (A) Data input. Matrix W of seven sites described by bird species abundance; matrix E of seven sites described by habitat descriptors; matrix B of bird species separated in food guilds; seven sites described by the time since the last fire event (TSF). (B) Trait information scaling-up. Matrix T with community-weighted mean trait values, obtained from matrix multiplication B’*W. (C) Derived variables and summarized analyses. TSF as independent variable for Linear Mixed-Effect Models (LME), with each dependent variable derived from data matrices. The first ordination axis of Matrix E (Habitat structure (PCA), in bold) was used as independent variable in separate models, with bird variables derived from matrices W and T as dependent variables. Finally, matrix E was used in Canonical Correspondence Analyses (CCA) with matrices W and T.	PMC7665042_41598_2020_76758_Fig2_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Stages in the discovery of new drugs in the context of precision medicine.	PMC8387781_gr1	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
A. Chest radiography showing the first position of the ingested coin. B. Reposition of the coin in the stomach and visualisation of the achalasia balloon. C, D. Oesophageal radiographs on postoperative day 12.	PMC5101516_cvja-27-e16-g001	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
PXDN mutant mice reveal impairment in bacterial clearance during acute lung infection.(A) Decrease of relative survival rates. PXDN-deficient and C57BL/6 wild-type mice were intratracheally instilled with 7 x 106 of P. aeruginosa strain K or PBS control. Relative survival rates were determined over a period of 48 hours; n = 9–11 per group, P = 0.0068. (B) Lung Bacterial burden. Mice were sacrificed at 20 hours; lungs were aseptically removed, weighed, and homogenized in PBS. Lung tissue suspension was serially diluted and plated on LB agar plates. After incubation at 37°C for 18 h, CFUs were counted and CFUs/mg tissue were calculated; n = 12 from 4 mice per group; one-way analysis of variance, P < 0.0001 for all comparisons. (C and D) Tissue burden on bacterial infection with sublethal dose was carried out by intratracheally infecting the mice with 3 x 106 of P. aeruginosa strain K. After 20 h, lung, liver and spleen were taken as in (B) for detection of bacteria. n = 15–21 from 5–7 mice per group; P (lung) = 0.016; P (liver) = 0.843; P (spleen) = 0.014. (E) H&E staining of the lungs from uninfected and infected mice. Mice were infected as in (C) and the lungs were harvested at 20 h for preparation of staining. a. WT mouse, uninfected; b, WT mouse, infected; c. PXDN-deficient mouse, uninfected; d, PXDN-deficient mouse, infected. Magnification: 400x. Scale: 5μm.	PMC5979044_ppatp1007026pg005	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Grad-CAM images of correct male height predictions. (a) VGG16, correct prediction for tall. (b) Inception-v3, correct prediction for tall. (c) Resnet50, correct prediction for tall. (d) VGG16, correct prediction for short. (e) Inception-v3, correct prediction for short. (f) Resnet50, correct prediction for short.	PMC9029985_entropy-24-00475-g007	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Nsp5 localizes to the endoplasmic reticulum (ER) but induces no ER stress. (A and B) MARC-145 cells were cotransfected with FLAG-nsp5 and ER marker pDsRed-ER (A) or mitochondria marker DsRed2-Mito (B). Thirty hours later, indirect immunofluorescence assay was performed, with nsp5 detected by anti-FLAG antibody. Nuclei were stained with DAPI (blue). (C) MARC-145 cells were transfected with FLAG-nsp5. After 30 h, an indirect immunofluorescence assay was conducted, with nsp5 detected by anti-FLAG antibody and Golgi labeled by anti-GOSR1 antibody. (D) HEK-293T cells were transfected with plasmids expressing GFP or GFP-tagged nsp5 together with reporter plasmid (GRP78-luc, GRP94-luc, CHOP-luc, XBP-1-luc, UPRE-luc, or ERSE-luc) and pRL-TK plasmid. Cells treated with TG (5 μM) for 4 h were used as positive controls. Thirty hours after transfection, the cells were harvested for luciferase reporter assays.	PMC10101144_spectrump04386-22-f002	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Paraffin-embedded cardiac sections of WT and Tr mice were stained using Masson’s Trichrome (A,C). (A) Shows whole slice of hearts, while (C) shows only infarct zones. Blue area indicates myocardial fibrosis, while red area indicates healthy muscle tissue. (B) Myocardial infarction size ratio and (D) myocardial fibrosis ratio were determined using MetaMorph 6.1 software. (E) Terminal Deoxynucleotidyl Transferase dUTP Nick End Labelling (TUNEL)-positive nuclei of paraffin-embedded sections from the mice hearts indicated in (A). Apoptotic cells appear brown, while normal cells appear blue. (F) Measurement of TUNEL-positive nuclei in cardiac sections from mice indicated in (A). (G) Measurement of reactive oxygen species (ROS) ratio using chloro methyl- 2’,7’-dichlorodihydrofluorescein diacetate (CM-H2DCFDA) staining from mice frozen cardiac sections. * Indicates p ≤ 0.05.	PMC7344501_biomedicines-08-00144-g007b	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
T1-weighted (a) and T2-weighted (b) MR images of bladder at different time points following injection of ultrasmall Fe3O4 nanoparticles. Temporal evolution of MR signals of the bladder for T1-weighted (c) and T2-weighted (d) imaging. (e) Quantification of Fe content in urine using ICP-OES. (f) Quantification of Fe3O4 nanoparticle internalization in RAW264.7 macrophages with different surface modifications	PMC11089712_12951_2024_2516_Fig3_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Optical microstructure obtained from samples taken from (a) thermal analysis casting, (b) die-cast alloy A, and (c) porosity observed in (b)-black arrows.	PMC9785003_materials-15-08844-g007b	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Simple CT image (axial image) of the abdomen and pelvis at each site of right hemi-colon, left hemi-colon and rectum. Diameter was measured at the most dilated site of the intestine (red line). (ce), cecum; (a), ascending colon; (hf), hepatic flexure; (t), transverse colon; (sf), splenic flexure; (d), descending colon; (s), sigmoid colon; (re), rectum.	PMC9820881_jcm-12-00341-g001	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
The core assumptions of Mendelian randomization.	PMC11333006_ponep0308151pg002	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Characterization of the Ag deposition on AuNPs for Routes D and E (Scheme 1). Panel (a) shows normalized scattering spectra of two representative NPs during the consecutive steps of silver enhancement procedure for NP with immobilized DNAzyme (top) and for NP without DNAzyme (bottom). Bare NP (red line), NP just before Ag enhancement reaction (green line), NP after Ag enhancement (blue line). Scattering spectra for other NPs are presented in Figures S2 and S3 in Supplementary Materials). Panel (b) shows representative SEM image of bare NP. Panel (c) shows representative SEM images of NPs after silver enhancement reaction for immobilized DNAzyme (top) and for NP without DNAzyme (bottom) (more SEM images in Figure S7). In both cases, Ag is deposited on the NPs. Silver forms a star-like shell on NPs with DNAzyme, but a different, rather unstructured shell is formed on NPs without DNAzyme (incubated with hemin alone).	PMC5424726_sensors-17-00849-g003	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Chest computed tomography scan showed the presence of subcutaneous emphysema (), pneumothorax (), and necrotizing pneumonia with empyema (arrows) (Part a). After chest drainage placement (), computed tomography scan showed the persistence of loculated pneumothorax (*) (Part b). Despite the insertion of chest tube (), right lower lobe did not expand as it was trapped by pleural adhesions (arrows) (Part c). Following closure of alveolar pleura fistula, chest computed tomography showed no progression of loculated pneumothorax (*) (Part d)	PMC6751653_13019_2019_987_Fig1_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Rat ESCs accelerate wound closure and improve the healing quality of rats. a The wound pictures of the rats’ dorsal skin of the negative control group and ESC group were taken on postinjury days 0, 3, 7, 14, and 21. b Residual wound rates of the negative control group and ESC group on postinjury days 0, 3, 7, 14, and 21. c Completed wound healing time of the negative control group and ESC group. *P < 0.05	PMC7414990_13287_2020_1844_Fig2_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Knockdown of LINC00460 suppresses HCC progression in vivo. (A, B) Pictures about tumor growth in the Lv-LINC00460 group and the control group was shown (C). Corresponding tumor growth curve. (D) The level of miR-342-3p was detected through qRT-PCR. (E, F) The expression of AGR2 was detected through western blot and data statistics was also shown. (G–H) Immunohistochemical (IHC) was conducted to examine the expression of Ki67 and VEGF in tissues. P < 0.05, *P < 0.01vs the control group.	PMC7346032_aging-12-103278-g006	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Innate immunity activated by biological materials for radioimmunotherapy. a CLSM imaging of the lysosomal escape of ovalbumin (OVA, green) in the presence of USLs, NonCSLs, and ACSLs in DCs after incubation for 12 h. The cells were stained with lyso-tracker (red). Scale bar, 20 µm. b Average tumor growth kinetics. c Survival of the mice.Reproduced from ref 85. Copyright 2021, Wiley–VCH GmbH. d Schematic diagram of combined chemotherapy, radiotherapy and immunotherapy using selenium nanoparticles. e Tumor volume of mice model after different treatments. f Confocal microscopy showing the tumor infiltration level of HLA-E (purple) and NK1.1(green). Reproduced from ref 30. Copyright 2020, Wiley–VCH Verlag GmbH & Co. KGaA, Weinheim	PMC10614396_12951_2023_2152_Fig5_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Left panel: Inconspicuous, two-dimensional X-ray of area 18/19 with a bone density of − 284HU. Middle panel: Immunohistochemistry shows a strong positive red staining for adipocytogenic R/C overexpression. Right panel: Multiplex R/C expression at a level of 1950 pg/mL (norm = 149 pg/mL)	PMC6883018_13167_2019_182_Fig4_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Schematic diagram of plant cell responses to stresses. (A) Sub-cellular trafficking and polarity maintenance of PIN proteins ( Adamowski et al. [18]; modified from Yin et al. [22]). GNO, guanylic acid exchange factor for ADP ribosylation factor; GA, Golgi apparatus; TGN/EE, trans-Golgi network/early endosome. (B) Working model of PIN transcription factor under abiotic stresses (heat, cold, salt, and drought). Solid arrows denote established positive effects, while dashed arrows indicate mechanisms that remain poorly understood. In the presence of abiotic stresses, cellular events such as elevated Ca2+ concentration, accumulation of reactive oxygen species (ROS), and protein degradation are initiated, ultimately transmitting the stress signal to the nucleus. Subsequently, PIN selectively binds to PLT/PID within the promoter region, activating the expression of stress-inducible genes. This concerted action enhances stress tolerance in plants.	PMC10855349_ijms-25-01452-g001	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
SEM images of copper-coated on PPC surface with different Cu2+ concentration (a) uncoated surface (b) 0.04 mol L−1 (c) 0.06 mol L−1 (d) 0.08 mol L−1.	PMC9055134_d0ra00461h-f12	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
A 56-year-old male patient with allogeneic ACL reconstruction.	PMC8940546_CIN2022-8256450p007	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Damage recognition, end resection, and checkpoint activation. The Mre11-Rad50-Xrs2 (MRX) complex detects double-strand breaks (DSBs) and binds to the break ends (only one end is shown). Xrs2 recruits Tel1 and checkpoint signaling is activated. Resection follows a two-step, bidirectional mechanism. MRX, together with its cofactor Sae2, initiates resection by endonucleolytic cleavage of the 5′-terminated strand, generating an entry site for long-range resection machineries, Exo1 and Sgs1-Dna2, to proceed in the 5′ to 3′ direction. Meanwhile, the MRX complex proceeds back towards the double-stranded DNA (dsDNA) end using its 3′ to 5′ exonuclease activity. Single-stranded DNA (ssDNA) generated by resection is coated by replication protein A (RPA), which recruits Ddc2 and the Mec1 checkpoint kinase.	PMC6315862_genes-09-00589-g001	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
PPRV associate extracellular vesicles enhance SLAM expression in the recipient cells.(A) PKH26-labeled EVs internalization by goat PBMCs (top); PKH26-labeled PBS were used as PKH26-only negative control (bottom) (Scale bar = 30 μm). (B) EVs isolated from PPRV-infected cells (EVs-PPRV) or from Mock-infected cells (EVs-Mock)were labeled with PKH26, and co-cultured with naive goat PBMCs for 48 h, immunofluorescent staining was performed to analysis the internalization of EVs and PPRV H protein expression in the recipient cells. PKH26-labeled PBS were used as PKH26-only negative control (Scale bar = 30 μm). (C, D, E) Equal quantities of EVs-PPRV or EVs-Mock were respectively co-cultured with the same amount of naive goat PBMCs for 48 h, and SLAM expression levels in the recipient cells were determined by RT-PCR (C), Western blot (D), and flow cytometry (E). Untreated goat PBMCs were used as the blank control. (F, G) Goat PBMCs were infected with PPRV at an MOI of 1 for 1 h and then maintained in medium containing indicated concentrations of GW4869 for 48 h. Then, the cells and the EVs isolated from the supernatants were subjected to Western blot for CD63, CD81, and PPRV H protein expression (F), and EVs were also subjected to NTA analysis(G). (H) Equal quantities of goat PBMCs infected with PPRV (MOI = 1) or Mock infected for 1 h and then maintained in medium containing indicated concentrations of GW4869 for 48 h. Then, the EVs from PPRV-infected cells (top) or Mock-infected cells (bottom) were respectively incubated with naive goat PBMCs that have the same amount of EVs-producing cells for 48 h and subjected to flow cytometry for SLAM expression. (I) Different fold number of EVs-PPRV were incubated with naive goat PBMCs for 48 h, and cells were harvested and subjected to flow cytometry for SLAM expression (top). Equal quantities of EVs-Mock incubated with the same amount of PBMCs were used as control (bottom). GAPDH was used as a loading control in RT-PCR and Western blot analysis. Data are given as means ± standard deviation (SD) from three independent experiments. P values were calculated using Student’s t test. An asterisk indicates a comparison with the indicated control. , P<0.05; *, P<0.01; n.s., not significant.	PMC9491601_ppatp1010759pg003	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Flowchart of the manuscripts handled by Tsuyoshi Miyakawa in Molecular Brain from December 2017 to September 2019	PMC7033918_13041_2020_552_Fig1_HTML	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Illustration of the difference between the measurement error and the measurement uncertainty. Since the “true value” of the measurand is never exactly known, the error can only be estimated.	PMC4862813_j62phif2	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Recoloration du gland après l’ablation de l’anneau métallique	PMC6201598_PAMJ-30-128-g002	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar
Lesion overlap map from the 50 participants overlaid on a standard MNI space brain after the right‐sided lesions had been flipped to the left side (see Methods section), and projected onto the whole set of axial slices from the canonical normal subject T1‐weighted MRI in Montreal Neurological Institute (MNI) space. The number of participants in each pixel is shown on the pseudo‐colour scale on the right. The maximum number of participants with a lesion for any voxel was 24 (red colour) and involved the striato‐capsular area and corona radiata. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]	PMC4738376_HBM-37-689-g001	hf://datasets/skip113/bmc6M@6e4197c66051f5bc6df5c97702ac633bc1669704/data/000001.tar