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Appl Bionics Biomech Appl Bionics Biomech ABB Applied Bionics and Biomechanics 1176-2322 1754-2103 Hindawi 10.1155/2023/9892836 Retraction Retracted: To Explore the Effects of Acupuncture and Medical Treatment at Different Times on the Gastrointestinal Reaction and White Blood Cell Count of Patients with Lung Cancer Chemotherapy and Biomechanics Applied Bionics [email protected] 2023 9 3 2023 9 3 2023 2023 989283631 1 2023 31 1 2023 Copyright (c) 2023 Applied Bionics and Biomechanics. 2023 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. pmc Applied Bionics and Biomechanics has retracted the article titled "To Explore the Effects of Acupuncture and Medical Treatment at Different Times on the Gastrointestinal Reaction and White Blood Cell Count of Patients with Lung Cancer Chemotherapy" due to concerns that the peer review process has been compromised. Following an investigation conducted by the Hindawi Research Integrity team , significant concerns were identified with the peer reviewers assigned to this article; the investigation has concluded that the peer review process was compromised. We therefore can no longer trust the peer review process and the article is being retracted with the agreement of the Chief Editor. The authors do not agree to the retraction. 1 Zhao Q. Du H. Liu J. Hua Y. Niu X. Chen J. To Explore the Effects of Acupuncture and Medical Treatment at Different Times on the Gastrointestinal Reaction and White Blood Cell Count of Patients with Lung Cancer Chemotherapy Applied Bionics and Biomechanics 2022 2022 7 10.1155/2022/5261344 5261344 2 Ferguson L. Advancing Research Integrity Collaboratively and with Vigour 2022 |
Comput Math Methods Med Comput Math Methods Med cmmm Computational and Mathematical Methods in Medicine 1748-670X 1748-6718 Hindawi 10.1155/2023/9848121 Retraction Retracted: Analysis of Clinical Characteristics of Hepatitis B and Alcohol-Related Liver Cancer Methods in Medicine Computational and Mathematical [email protected] 2023 9 3 2023 9 3 2023 2023 984812131 1 2023 31 1 2023 Copyright (c) 2023 Computational and Mathematical Methods in Medicine. 2023 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. pmc Computational and Mathematical Methods in Medicine has retracted the article titled "Analysis of Clinical Characteristics of Hepatitis B and Alcohol-Related Liver Cancer" due to concerns that the peer review process has been compromised. Following an investigation conducted by the Hindawi Research Integrity team , significant concerns were identified with the peer reviewers assigned to this article; the investigation has concluded that the peer review process was compromised. We therefore can no longer trust the peer review process and the article is being retracted with the agreement of the Chief Editor. The authors do not agree to the retraction. 1 Pan Y. Han G. Analysis of Clinical Characteristics of Hepatitis B and Alcohol-Related Liver Cancer Computational and Mathematical Methods in Medicine 2021 2021 8 9752534 10.1155/2021/9752534 2 Ferguson L. Advancing Research Integrity Collaboratively and with Vigour 2022 |
J Environ Public Health J Environ Public Health jeph Journal of Environmental and Public Health 1687-9805 1687-9813 Hindawi 10.1155/2023/9867104 Retraction Retracted: Securitization Concept and Its Application to Environmental Problems in the Kurdistan Region: Prospects and Obstacles Environmental and Public Health Journal of [email protected] 2023 9 3 2023 9 3 2023 2023 986710414 2 2023 14 2 2023 Copyright (c) 2023 Journal of Environmental and Public Health. 2023 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. pmc Journal of Environmental and Public Health has retracted the article titled "Securitization Concept and Its Application to Environmental Problems in the Kurdistan Region: Prospects and Obstacles" due to concerns that the peer review process has been compromised. Following an investigation conducted by the Hindawi Research Integrity team , significant concerns were identified with the peer reviewers assigned to this article; the investigation has concluded that the peer review process was compromised. We therefore can no longer trust the peer review process, and the article is being retracted with the agreement of the Chief Editor. Nusret Sinan Evcan agrees to the retraction; Salam Abdulqadir Abdulrahman was unresponsive. 1 Abdulrahman S. A. Evcan N. S. Securitization Concept and Its Application to Environmental Problems in the Kurdistan Region: Prospects and Obstacles Journal of Environmental and Public Health 2022 2022 9 8122568 10.1155/2022/8122568 2 Ferguson L. Advancing Research Integrity Collaboratively and with Vigour 2022 |
Pain Res Manag Pain Res Manag PRM Pain Research & Management 1203-6765 1918-1523 Hindawi 10.1155/2023/9756947 Erratum Erratum to "miR-223 Inhibits the Polarization and Recruitment of Macrophages via NLRP3/IL-1b Pathway to Meliorate Neuropathic Pain" Zhu Junsong 1 Yang Jinmei 2 Xu Jianguo [email protected] 3 4 1Pain Department, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430081, China 2Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan 430022, China 3Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China 4Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan 430074, China 2023 9 3 2023 9 3 2023 2023 97569476 12 2022 6 12 2022 Copyright (c) 2023 Junsong Zhu et al. 2023 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. pmcIn the article titled "miR-223 Inhibits the Polarization and Recruitment of Macrophages via NLRP3/IL-1b Pathway to Meliorate Neuropathic Pain" , there was an error in the corresponding author details during production. The correct contact information is shown above. Authors' Contributions Junsong Zhu and Jinmei Yang contributed equally to this research. 1 Zhu J. Yang J. Xu J. miR-223 Inhibits the Polarization and Recruitment of Macrophages via NLRP3/IL-1b Pathway to Meliorate Neuropathic Pain Pain Research and Management 2021 2021 11 6674028 10.1155/2021/6674028 |
in the PDF proof were corrected. |
Front Pediatr Front Pediatr Front. Pediatr. Frontiers in Pediatrics 2296-2360 Frontiers Media S.A. 10.3389/fped.2023.1170918 Pediatrics Erratum Erratum: Pseudo-feeders as a red flag of impending or ongoing severe brain damage in Vein of Galen Aneurysmal Malformation Frontiers Production Office* Frontiers Media SA, Lausanne, Switzerland Approved by: Frontiers in Pediatrics, Frontiers Media SA, Switzerland * Correspondence: Frontiers Production Office [email protected] Specialty Section: This article was submitted to Pediatric Neurology, a section of the journal Frontiers in Pediatrics 03 3 2023 2023 03 3 2023 11 117091821 2 2023 21 2 2023 (c) 2023 Frontiers Production Office. 2023 Frontiers Production Office This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Vein of Galen Aneurysmal Malformation outcome prognostic factor encephalomalacia pseudo-feeders pmcAn Erratum on Pseudo-feeders as a red flag for impending or ongoing severe brain damage in Vein of Galen aneurysmal malformation By Saliou G and Buratti S. (2022) Front. Pediatr. 10:1066114. doi: 10.3389/fped.2022.1066114 An omission to the funding section of the original article was made in error. The following sentence has been added: "Open access funding was provided by the University of Lausanne" The original version of this article has been updated. |
Glob Adv Integr Med Health Glob Adv Integr Med Health spgam GAM Global Advances in Integrative Medicine and Health 2753-6130 SAGE Publications Sage CA: Los Angeles, CA 10.1177_27536130231161197 10.1177/27536130231161197 Corrigendum Corrigendum to "Comparing Types of Yoga for Chronic Low Back and Neck Pain in Military Personnel: A Feasibility Randomized Controlled Trial" 15 3 2023 Jan-Dec 2023 15 3 2023 12 27536130231161197(c) The Author(s) 2023 2023 Academic Consortium for Integrative Medicine & Health, unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses This article is distributed under the terms of the Creative Commons Attribution 4.0 License ) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ). typesetterts10 cover-dateJanuary-December 2023 pmcGroessl EJ, Casteel D, McKinnon S, et al. Comparing Types of Yoga for Chronic Low Back and Neck Pain in Military Personnel: A Feasibility Randomized Controlled Trial. Global Advances in Health and Medicine. 2022;11. doi:10.1177/2164957X221094596 In the above-mentioned article, the author name should read as "Douglas G Chang". The correction has been updated in the online version. |
Front Neurosci Front Neurosci Front. Neurosci. Frontiers in Neuroscience 1662-4548 1662-453X Frontiers Media S.A. 10.3389/fnins.2023.1167744 Neuroscience Erratum Erratum: Frontal and parietal lobes play crucial roles in understanding the disorder of consciousness: A perspective from electroencephalogram studies Frontiers Production Office * Frontiers Media SA, Lausanne, Switzerland Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland *Correspondence: Frontiers Production Office [email protected] This article was submitted to Perception Science, a section of the journal Frontiers in Neuroscience 03 3 2023 2023 03 3 2023 17 116774416 2 2023 16 2 2023 Copyright (c) 2023 Frontiers Production Office. 2023 Frontiers Production Office This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. An Erratum on Frontal and parietal lobes play crucial roles in understanding the disorder of consciousness: A perspective from electroencephalogram studies by Liu, Y., Li, Z., and Bai, Y. (2023). Front. Neurosci. 16:1024278. doi: 10.3389/fnins.2022.1024278 frontal parietal neural correlates of consciousness electroencephalogram (EEG) disorder of consciousness (DOC) pmcDue to a production error, the affiliation of reviewer Yi Yang is incorrect. The affiliation "University Hospital and University of Liege, Belgium" has been changed to: "Beijing Tiantan Hospital Affiliated to Capital Medical University, China." The publisher apologizes for this mistake. The original article has been updated. |
Front Psychol Front Psychol Front. Psychol. Frontiers in Psychology 1664-1078 Frontiers Media S.A. 10.3389/fpsyg.2023.1170205 Psychology Erratum Erratum: Animalistic dehumanisation as a social influence strategy Frontiers Production Office * Frontiers Media SA, Lausanne, Switzerland Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland *Correspondence: Frontiers Production Office [email protected] This article was submitted to Personality and Social Psychology, a section of the journal Frontiers in Psychology 03 3 2023 2023 03 3 2023 14 117020520 2 2023 20 2 2023 Copyright (c) 2023 Frontiers Production Office. 2023 Frontiers Production Office This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. An Erratum on Animalistic dehumanisation as a social influence strategy by Quiamzade, A., and Lalot, F. (2023). Front. Psychol. 13:999959. doi: 10.3389/fpsyg.2022.999959 dehumanisation animalisation influence resistance essentialism justification pmcAn omission to the funding section of the original article was made in error. The following sentence has been added: "Open access funding was provided by the University of Geneva." The publisher apologizes for this mistake. The original article has been updated. |
Front Psychiatry Front Psychiatry Front. Psychiatry Frontiers in Psychiatry 1664-0640 Frontiers Media S.A. 10.3389/fpsyt.2023.1171192 Psychiatry Erratum Erratum: Social support needs of first-time parents in the early-postpartum period: A qualitative study Frontiers Production Office * Frontiers Media SA, Lausanne, Switzerland Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland *Correspondence: Frontiers Production Office [email protected] This article was submitted to Mood Disorders, a section of the journal Frontiers in Psychiatry 03 3 2023 2023 03 3 2023 14 117119221 2 2023 21 2 2023 Copyright (c) 2023 Frontiers Production Office. 2023 Frontiers Production Office This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. An Erratum on Social support needs of first-time parents in the early-postpartum period: A qualitative study by Schobinger, E., Vanetti, M., Ramelet, A.-S., and Horsch, A. (2022). Front. Psychiatry 13:1043990. doi: 10.3389/fpsyt.2022.1043990 social support early postpartum mothers fathers needs qualitative pmcAn omission to the funding section of the original article was made in error. The following sentence has been added: "Open access funding was provided by the University of Lausanne." The original article has been updated. |
Stem Cells Transl Med Stem Cells Transl Med stcltm Stem Cells Translational Medicine 2157-6564 2157-6580 Oxford University Press US 10.1093/stcltm/szad001 szad001 Correction AcademicSubjects/MED00770 AcademicSubjects/SCI00960 Correction to: Transient Inhibition of the JNK Pathway Promotes Human Hematopoietic Stem Cell Quiescence and Engraftment 3 2023 30 1 2023 30 1 2023 12 3 183183 (c) The Author(s) 2023. Published by Oxford University Press. 2023 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. pmcThis is a correction to: Huangfan Xie, Zhongjie Sun, Xiong Xiao, Defang Liu, Hailong Qi, Guoxiong Tian, Miao Chen, Ligong Chen, XunCheng Su, Transient Inhibition of the JNK Pathway Promotes Human Hematopoietic Stem Cell Quiescence and Engraftment, Stem Cells Translational Medicine, Volume 11, Issue 6, June 2022, Pages 597-603, In the originally published version of this article, the institutional affiliations labeled 1 and 2 were presented in the wrong order. These should have been presented as follows: 1. State Key Laboratory of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China 2. School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China This error has been corrected. |
Braz J Med Biol Res Braz J Med Biol Res bjmbr Brazilian Journal of Medical and Biological Research 0100-879X 1414-431X Associacao Brasileira de Divulgacao Cientifica 00901 10.1590/1414-431X2023e8793erratum Erratum Erratum notice for: "Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways" [Braz J Med Biol Res 2020;53(2): e8793] 17 3 2023 2023 17 3 2023 56 e8793erratum This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. pmcZhengbo Zhao1* Han Liu2* and Dongmei Guo3 1Department of Cardiovascular Medicine, Jiulongpo District People's Hospital, Chongqing, China 2Department of Neurology, Jiulongpo District People's Hospital, Chongqing, China 3Department of Cardiovascular Medicine, Nanchuan District People's Hospital, Chongqing, China Correspondence: Dongmei Guo: <[email protected]> *These authors contributed equally to this study. The authors notified the Editors of the Brazilian Journal of Medical and Biological Research that there was an error in Figure 1A, due to inappropriate image processing. The conclusion of the results remains unchanged. The correct Figure 1 is: Figure 1 Effect of aliskiren (ALS) on cardiomyocyte size in isoproterenol (ISO)-treated rats. A, Hematoxylin and eosin staining was performed and (B) the width of cardiomyocytes was measured (n=6 per group). Data are reported as means+-SE. *P<0.05 compared with vehicle; #P<0.05 compared with the ISO-treated group (ANOVA followed by Tukey's post hoc test). |
Galactics. Liquid food, including milk, good nutritious soups, ale or beer, and other malt liquors. Lager-beer is much inferior to ordinary ale in promoting the secretion of milk, and principally as it would seem from the effect of the pitch with which it is impregnated, and which acts so and immediately upon the skin and kidneys, creating such a secretion of perspiration and urine, that the tendency to the breast is thus neutralized. " Spirituous liquors, instead of increasing, as many suppose, diminish the quantity of milk secreted." Faeniculum. Hippocrates, as well as Galen, already speaks of fennel as a means of increasing the lacteal secretion. Dioscorides ascribes the same powers to it (lib. III. chap. Ixvii et seq.). According to Mitscherlich, also, it increases besides other secretions, certainly that of milk (Stille's Therap. and Materia Medica, vol. 1, p. 592). In Germany, especially, it has been tried extensively and lauded correspondingly. It is given either alone as infusion ad libit, or combined with various other articles still to enhance its power. Among the most celebrated and valuable formula is that of Hufeland : If. Sem. Foeniculi,................3 i; Flav. Cort. Aurant............3 ss ; Subcarb Magnes................3 iij; Sacch. Alb....................3 . ft. pulv. Dose a teaspoonful three times a day. I have obtained surprising results from Hufeland's formula, which I have employed in several cases, in one where the secretion had been suppressed for three weeks. Prof. Amer. JFed. Times. |
ON GLYCOSURIA AS AN ACCOMPANIMENT OF MARSH FEVERS. IJ Y DR. JSL'RDEIj, Physician, to the Vierzon Hospital. Dr. Burdel regards marsh poison as a myth, and looks upon marsh fever as a result of a perturbation of the cerebro spinal centre and the sympathetic system, adopting very nearly the same phrase as the one by which Bernard defines glycosuria. The author of the present paper, in his researches into the nature of marsh fever, has confirmed the above view of its character by ascertaining in the majority of cases the presence of sugar in the urine. Dr. Burdel employed the test with liquor potassae, Feeling's liquids, the test with bismuth and potash or carbonate of soda, and the yeast test. It was especially in the first of the attack that the quantity of sugar was ; it diminished gradually towards the termination of the paroxysm, and generally disappeared entirely during the interval. The closer the attacks approach one another, the larger the amount of sugar. In eighty cases of well marked intermittent fever, the uniformly found sugar; in thirty other cases, in which the fever was at first intermittent and subsequently became remittent, the sugar was present, but only in small quantity and for brief space. In two cases of intermittent fever, typhoid fever, a considerable quantity of sugar was shown to be present. In the case presenting the largest quantity of sugar, as much as 10 per 1000 was found. I? Union Medicate. |
PLOS Glob Public Health PLOS Glob Public Health plos PLOS Global Public Health 2767-3375 Public Library of Science San Francisco, CA USA 10.1371/journal.pgph.0000592 PGPH-D-22-00838 Correction Correction: Benchmarking alcohol policy based on stringency and impact: The International Alcohol Control (IAC) Policy Index The PLOS Global Public Health Staff 31 5 2022 2022 31 5 2022 2 5 e0000592 2022 The PLOS Global Public Health Staff 2022 The PLOS Global Public Health Staff This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Benchmarking alcohol policy based on stringency and impact: The International Alcohol Control (IAC) Policy Index pmcNotice of republication This article was republished on May 17, 2022, to correct the XML version of the article which displayed an incorrect notation beside two authors names in the byline. The publisher apologizes for the errors. Please download this article again to view the correct version. The originally published, uncorrected article and the republished, corrected articles are provided here for reference. Supporting information S1 File Originally published, uncorrected article. (PDF) Click here for additional data file. S2 File Republished, corrected article. (PDF) Click here for additional data file. Reference 1 Casswell S , Huckle T , Parker K , Romeo J , Graydon-Guy T , Leung J , et al . (2022) Benchmarking alcohol policy based on stringency and impact: The International Alcohol Control (IAC) policy index. PLOS Glob Public Health 2 (4 ): e0000109. 10.1371/journal.pgph.0000109 |
Front Med (Lausanne) Front Med (Lausanne) Front. Med. Frontiers in Medicine 2296-858X Frontiers Media S.A. 10.3389/fmed.2023.1171820 Medicine Erratum Erratum: Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson's disease Frontiers Production Office * Frontiers Media SA, Lausanne, Switzerland Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland *Correspondence: Frontiers Production Office [email protected] This article was submitted to Nuclear Medicine, a section of the journal Frontiers in Medicine 03 3 2023 2023 03 3 2023 10 117182022 2 2023 22 2 2023 Copyright (c) 2023 Frontiers Production Office. 2023 Frontiers Production Office This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. An Erratum on Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson's disease by Boccalini, C., Carli, G., Vanoli, E. G., Cocco, A., Albanese, A., Garibotto, V., and Perani, D. (2022). Front. Med. 9:1073720. doi: 10.3389/fmed.2022.1073720 Parkinson's disease MIBG scintigraphy H/M ratios manual-drawing approach semi-automatic fixed-size ROIs pmcAn omission to the funding section of the original article was made in error. The following sentence has been added: "Open access funding was provided by the University of Geneva." The original article has been updated. |
RSC Adv RSC Adv RA RSCACL RSC Advances 2046-2069 The Royal Society of Chemistry d3ra90021e 10.1039/d3ra90021e Chemistry Correction: New silicon substituted BiMeVOx: synthesis and study of structural properties in relation to ionic conductivity Agnaou A. a Mhaira W. a Essalim R. a Zamama M. a Mauvy F. b Alga M. a Ammar A. a a Laboratoire des Sciences des Materiaux et Optimisation des procedes, Faculte des Sciences-Semlalia, Universite Cadi Ayyad Av. My Abdellah B. P. 2390 Marrakech Morocco b CNRS, Univ. Bordeaux, Bordeaux INP, ICMCB, UMR 5026, 87 F-33600 Pessac France [email protected] 17 3 2023 14 3 2023 17 3 2023 13 13 89438943 14 3 2023 14 3 2023 This journal is (c) The Royal Society of Chemistry 2023 The Royal Society of Chemistry Correction for 'New silicon substituted BiMeVOx: synthesis and study of structural properties in relation to ionic conductivity' by A. Agnaou et al., RSC Adv., 2023, 13, 8015-8024, pubstatusPaginated Article pmcThe authors regret that the name of one of the authors (A. Agnaou) was shown incorrectly in the original article. The corrected author list is as shown above. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers. Supplementary Material |
as published. The Abstract previously stated, "In part two these compatibilities are brought together with the that these compatibilities can be brought together with the philosophy of Gilbert Simondon to develop the notion of enhabiting." This should be, "In part two these compatibilities are brought together with the philosophy of Gilbert Simondon to develop the notion of enhabiting." The corrected abstract appears below: Baggs and Chemero (2018) propose that certain tensions between enaction and ecological psychology arise due different interpretations about what is meant by the "environment." In the enactive approach the emphasis is on the umwelt, which describes the environment as the "meaningful, lived surroundings of a given individual." The ecological approach, on the other hand, emphasises what they refer to as the habitat "the environment as a set of resources for a typical, or ideal, member of a species." By making this distinction, these authors claim they are able to retain the best of both the ecological and the enactive approaches. Herein I propose an account of the individuation of habits that straddles this distinction, what I call a compatabilist account. This is done in two parts. The first part teases out a host of compatibilities that exist between the enactive account as developed by Di Paolo et al. (2017) and the skilled intentionality framework as developed by Bruineberg and Rietveld (2014) and Rietveld and Kiverstein (2014). In part two these compatibilities are brought together with the philosophy of Gilbert Simondon to develop the notion of enhabiting. Enhabiting describes a set of ongoing processes by which an umwelt emerges from and is reproduced within the relationship between an embodied subject and their habitat. Thus, enhabiting points toward a point of intersection between enaction and ecological psychology. To enhabit is bring forth (to enact), within (to inhabit). The author apologizes for this error and states that this does not change the scientific conclusions of the article in any way. The original article has been updated. Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. |
PLoS One PLoS One plos PLOS ONE 1932-6203 Public Library of Science San Francisco, CA USA 10.1371/journal.pone.0283443 PONE-D-23-07183 Correction Correction: Transparency in conducting and reporting research: A survey of authors, reviewers, and editors across scholarly disciplines The PLOS ONE Staff 17 3 2023 2023 17 3 2023 18 3 e0283443(c) 2023 The PLOS ONE Staff 2023 The PLOS ONE Staff This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Transparency in conducting and reporting research: A survey of authors, reviewers, and editors across scholarly disciplines pmcNotice of Republication This article was republished on March 10, 2023, to address figure errors. The publisher apologizes for the errors. Please download this article again to view the correct version. The originally published, uncorrected article and the republished, corrected articles are provided here for reference. Supporting information S1 File Originally published, uncorrected article. (PDF) Click here for additional data file. S2 File Republished, corrected article. (PDF) Click here for additional data file. Reference 1 Malicki M , Aalbersberg IJ , Bouter L , Mulligan A , ter Riet G (2023) Transparency in conducting and reporting research: A survey of authors, reviewers, and editors across scholarly disciplines. PLoS ONE 18 (3 ): e0270054. 10.1371/journal.pone.0270054 36888682 |
EXTRACT FROM FOREIGN CORRESPONDENCE THE OLD UNIVERSITY OF BOLOGNA. Venice, Feb. 80th, 1870. Dear Father: I left Florence on Thursday last, coming on as far as Bologna, where I stopped over a few hours, in order to visit the old and once celebrated University of ; an institution which numbered at one time 4000 students and 300 professors; its medical school, especially, being for a long time the most celebrated in Europe. It was here that the first human body was dissected and the first anatomical made. The museum is still one of the most complete and extensive in the world, both in human and comparative anatomy. The library comprises some 15,000 volumes; among them some very valuable manuscripts. The celebrated linguist , who is said to have spoken fluently 42 different . It is a curious fact, in connection with this university, that several of the most important chairs those of History, Natural Philosophy, Literature, and even Anatomy, have, at different times, been filled by ladies. A wax figure of the lady was pointed out to me, in the museum, bending over the table with scalpel in hand, as natural as life, and surrounded on either hand by her own preparations. Another young lady, the daughter of one of the Professors, lectured on history, and is said to have been so beautiful that she was obliged to lecture with a curtain before her face, in order that the attention of the students should not be distracted from the subject of her discourse. The university is still honorably maintained, there being some 400 students in attendance, I was told. There is quite an extensive hospital in connection with the medical school, where regular clinical instruction is given. I had intended to remain over long enough to attend some of the lectures and clinics, but the weather was very cold and unpleasant, the hotel no carpets on the floors, and no means of warming any of the rooms so that I did not think it prudent to remain long, but hastened on here, in hopes of finding pleasanter weather. It is no better here, however cold, damp, and uncomfortable. F. H. D. |
o r pon cl e nre. A REMARKABLE FALL. Mount Carroll, III., March 27, 1870. A Miss A. B., age 13, while sliding on the snow, February 5, accidentally ran over a perpendicular precipice of 54 feet (measured), alighting on the ice of the mill-dam below. The sled was broken. She was soon found and taken home, soon recovering sensibility; no bones were broken. I was called in consultation with Dr. Etter and Dr. Miller, on the following day. There wras some soreness in the gluteal regions and about the pelvis; the bladder was paralized, so as to require the use of the catheter three times. Temperature 101deg. She made a complete recovery in two weeks. Had she been in the same condition from a fall of six feet, the friends would have seen no cause for alarm. HENRY SHIMER, Relapsing Fever In Edinburgh. This fever has at last broken out in Edinburgh, in two different localities, without, we believe, any contagious influence being traceable in either case. The history of this outbreak, carefully recorded, as we hope it shall be, must form one of the most interesting episodes in the modern history of fever, as well as a not unimportant to the vexed question of change of type. Edinburgh Med. Journal, March, 1870. |
ARTICLE VII. CASE OF COCCYODYNIA. By W. R. FOX, M.D., San Leandro, Cal. Mrs. K., aged 23, a resident of Wilmington, Ill., consulted me February 1st, 1869, about a severe pain in the region of the coccyx. I learned from her, that ten months previous to this date she was delivered of her first child, after a tedious labor. Her recovery from the accouchment was imperfect, for months from symptoms of anaemia. Although her general health had improved somewhat, under tonic and restorative treatment, yet she complained greatly of pain in the lower part of the back. The pain was very much aggravated by walking, sitting down, or rising from the sitting posture. Upon examination, I found the lower joint of the coccyx to be motionless and tender to the touch. The pelvic organs were in a healthy condition, except that there was slight prolapsus uteri. There was no vaginismus. I pronounced the case to be coccyodynia, and advised amputation of a portion of the coccyx. As she had obtained no relief from treatment, but was growing worse, she readily consented to the operation. The operation was performed in the following manner: The patient was placed on the right side; and with the index-finger in the rectum, I made firm pressure outwardly. Then an was made on the median line, down to the bone, and of length to admit of disarticulation at the second joint. The two lower bones were then separated from their and severed at the second joint with small bone forceps. The wound was closed with metallic sutures, and the greater part healed by the first intention. My friend, Dr. E. R. , assisted at the operation. The result, in this case, was perfectly satisfactory. In a few weeks, Mrs. K. was attending to her household duties, free from pain, having greatly improved mentally and physically. A short time since, I received a note from her saying she was in the enjoyment of good health, the operation having been a success, etc. Dr. J. C. Nott, formerly of Mobile, recommended and this operation 25 years ago, 15 years before the of the profession was called to it by Professor Simpson. |
THE CHICAGO MEDICAL SOCIETY. This Society holds its regular meetings during the summer, on the first and third Monday of every month. The subject for discussion, on June 20th, was the of infants, its causes and medical treatment. Drs. Quine, Paoli, Fitch, Davis, and Gray expressed their views. They all condemned the use of strong purgatives and injections; the former as liable to increase the difficulty, and the latter to and weaken the muscular fibres. Dr. Paoli had used a wrax bougie, to excite the peristaltic action of the bowel, and recommended suppositories of tallow or soap, for the same purpose. Dr. Fitch had found much benefit from electricity, applied to the back and along the course of the colon, also from a prescription containing I|i. Tinct. Aloes, Syrup Ipecac, Fl. Ex. Rhubarb. Dr. Davis believed much of the difficulty arose from a lack of the peristaltic action of the bowel, and to stimulate their fibres, often used with a beneficial effect minute doses of tinct* nux vomica, perhaps, 1 drop; syrup ipecac, perhaps, 5 drops; and might add, sometimes, with benefit, syrup rhubarb or tinct. belladonna. Dr. Gray thought hydrastin and nux vomica would succeed well. '# ' Dr. Holmes presented some interesting pathological from the eye, one a melanotic, and another of which, he thinks, there are but six similar on record a non-pulsating erectile tumor. This being removed, the eye resumed its position in the orbit. |
sKirnR nomcs Renal Diseases: A Clinical Guide to their Diagnosis and . By W. R. Basham, M.D.; Fellow of the Royal of Physicians; Senior Physician to the Westminster Hospital, and Lecturer on Medicine, etc., etc. With . Philadelphia: Henry C. Lea. 1870. For sale by S. C. Griggs & Co. Price $2. This is a small-sized octavo volume of 304 pages, neatly printed and elegantly bound; and contains, in a small compass, a good summary of the present knowledge in the profession, in regard to renal diseases and their treatment. Eighth Annual Report of the Board of Public Works, to the Common Council of the City of Chicago, for the year ending March 31st, 1869. This is a volume of 207 pages, containing a very interesting statement of facts concerning the progress and present condition of the public improvements in this city. In regard to the extent of the water pipes, supplying water from the lake tunnel, the report says: "There are now laid in the city, of mains of all sizes, 208 miles and 3117 feet. This extent of pipes laid exceeds that of any other city in our coun tty, excepting New York, Brooklyn, and Philadelphia." Connected with the water pipes are 1070 fire hydrants. The total income received from water rents and taxes, during the year ending March 31st, 1869, amounted to $420,686.94." Total expenses for interest on debt and operating expenses $309,694.50; leaving a surplus revenue, to be applied to improvements, of $110,992.44. Total cost of the water works of the city, up to date of the report, $3,146,383.14. The sewers of the city are all laid on a definite plan or system, and the total length of sewers laid in the city, up to March 31st, 1869, was 110| miles." The report of the Board is accompanied by many interesting maps, and illustrations, and plans for future improvement. |
Hypodermic Use of Iodine in Goitre. Prof. Lucke (BraithewuitAs Retrospect) treats goitre bv injecting four or five drops of tincture of iodine, and repeating the injection every eight days or so, gradually increasing the quantity. St. Louis Med. Archives. |
<< n o o 11 r t << On the Wasting Diseases of Infants and Children. By Smith, M.D., London; Member of the Royal College of Physicians, etc., etc., etc. Philadelphia: Ilenry C. Lea. 1870. This is a neatly published octavo volume of 195 pages. It contains an introductory chapter of 25 pages, a chapter on simple atrophy, from insufficient nourishment, one on chronic diarrhoea, one on chronic vomiting, one on rickets, on syphilis, on worms, on chronic tuberculosis, on chronic phthisis, and on tuberculization of glands. These subjects are considered at length and with ability. For sale at S. C. Griggs & Co.'s, Chicago. Price $1.50. Obstetric Aphorisms, for the Use of Students commencing Practice. By Joseph Griffiths Swayne, M.D.; Physician Accoucher to the Bristol General Hospital, and Instructor in Obstetric Medicine in the Bristol Medical School. From the Fourth Revised English Edition, with Additions.by Edward R. IIutci-iins, M.D. Philadelphia: Henry C. Lea. 1870. Duodecimo; pp. 177. Price $1.25. We have received the above neat and convenient little , through the bookstore of S. C. Griggs & Co., of this city. It is a very convenient little manuel for reference, particularly for students and young practitioners; and the fact that it has passed through four English editions, is evidence that it positive merits. |
Professor Bigelow's Letter in our last number. The following is from the Boston Medical and Surgical Journal, Jan. 27. Erratum. The word "published"* was here , in the printed proof, for made public. By seeming to refer to the printing of my paper in 1869 instead of its reading in 1861 (see p. 10), it does injustice to certain European observations in 1865-8 ; and on this account I am unwilling to leave it uncorrected. But this is a separate and here wholly incidental question. As far as the passage relates to Prof. Gunn, I believe it to be strictly correct as it stands. I cannot find that he alludes to the ilio-femoral ligament before Sept. 17th, 1869. II. J. B. *At the end of the last paragraph but two. |
ARTICLE XXIX. TRAUMATIC, IRIDEREMIA, AND APHAKIA. By C. HIXSON, M.D., formerly Prof, of Ophthamology in the Kansas City College of Physicians and Surgeons. The infrequency of cases like the following is a sufficient apology for its publication. Mr. B., of Kansas, is a sawyer by occupation, and sometime in January last, was struck by a small chip hurled with great velocity from the saw, which entered the centre of the right eye, making an incision of more than three-fourths of the diameter of the cornea. Being remote from any professional assistance, his wife did the surgery in the case. Cold applications were made at intervals for several days, when what he describes as strings of pus was found in the wound, and which his wife pulled away with considerable pain on the part of the patient. The eye gradually improved, and to-day I find the following interesting condition of affairs: There is, extending in a vertical line, embracing about of the diameter of the cornea, a firm, opaque cicatrix. There is not a vestige of the iris to be seen in the injured eye. The iris of the left eye is a very light grey, and contrasted with the deep, dark, blackness of the injured eye, is remarkable. The only thing seen by lateral illumination or by the is a few opaque filaments of the capsule. There is complete aphakia. Without a glass, the patient, has only perception of light everything is blurred and indistinct. With a cataract glass and through a stenopaic hole, he can read No. 4 Sneller at 18 inches. He is very much annoyed by the inability to focus the rays of light equally in the two eyes, and I hope by a stenopaic catacact glass to be able to do away with this difficultuy to a considerable extent, if not entirely. |
Excision of a Scapula. Dr. Schuppert has excised the scapula of a woman 36 years old, for a tumor involving nearly the entire bone. The operation was recovered from promptly, the patient having a tolerably useful arm one more useful, indeed, than before the operation. There was very little hemorrhage, partly due to the obliteration of some large vessels in a former operation. This is the tenth reported case of this operation. New Orleans Jour. Med. |
Uterine Injections in Endometritis. Dr. Nott, of New York (Journal of Obstf writes a lengthy article on the of endometritis by uterine injections. lie strongly the indiscriminate use of caustics and powerful stimulants to the inflamed and ulcerated uterus, as well as the almost sole reliance which not a few practitioners place on local treatmenu for uterine diseases. His conclusions regarding the treatment of the disease in question are substantially as follows: 1. That the appalling symptoms sometimes following the use of uterine injections are induced by the passage of fluid through the Fallopian tubes into the peritoneal cavity, is decidedly ; they are more likely due to some effect produced upon the uterus. 2. If the fluid could always be prevented from over-filling the uterus, no such disaster would ever follow the use of an injection of proper strength; a free exit for the liquid would obviate the difficulty. 3. He has invented an instrument, which he figures, that will accomplish this purpose. It consists of a large catheter, within which is a small tube. The fluid is forced in through the little tube; it passes out an orifice into the uterus, and finds egress at once through the catheter, which it enters through ample slits. Instead of sponge tents for dilating the os uteri, he uses a pair of curved dilating forceps, which act on the principle of the glove-stretcher. With this he makes forcible and rapid dilatation. |
Does Mental Influence in the Mother Produce in the FCetus. The American Journal of contains an article on this subject, by Dr. G. J. Fisher, of which the following is a brief summary: It is a traditional superstition, for which the medical is largely responsible, that malformations are the result of maternal mutual emotions. Various and intense emotions are common in gestating women, as are apprehensious of of their offspring, yet abnormal births are rare. There is nothing like law on the alleged results of maternal mental influences in the production of malformations, and the occasional apparent relation of cause and effect is due, usually, to accidental coincidences, which would be far less frequent if the facts could be ascertained before instead of after the birth' of the child. The coincidences are not sufficiently numerous and authentic to warrant the belief that they are anything else. Like cause produce like results; whereas widely dissimilar emotions are assigned for causes of the same deformity. Some of the assumed causes are alleged to have operated on the foetus subsequent to the time for the evolution of the part . In a large proportion of the malformations no or physical explanation is offered by the parents. The alleged resemblance of maculae to contain fruits and >s nurely accidental or is the result of imagination Malformations identicle in kind and degree recur often on the human subject, and admit of classification. They all have their exact morphological counterpart in the lower animals, as well as some that are analogous in the vegetable kingdom. Monstrosities are not the result of violation of embryological or physiological laws; they are the product of embarrassment, to normal development, either retarded, arrested, or excessive development. In plural conception it is absurd to suppose mental emotion can be conveyed to one foetus in the womb and not to the other, whether it be transmitted through the blood, by undiscovered nerves in the funis, or by some animal magnetism directly across tissues. The development of united-embryos is now known to follow definite laws. Monstrosities may arise from either abnormalities of the generative matter of one or both parents, or of the material organism, or from abnormal states of the membranes of the ovum and umbilical cord. The time has fully come to repel the popular error that anomalies of organization are due to mental emotions; and it is the duty of the medical profession to aid, as they carry on this consummation. |
Copper as a Preventive of Cholera. M. Berg says a society of coppersmiths, through four successive cholera , enjoyed almost complete immunity from the scourge, while people of all classes around them were dying by hundreds. From minute inquiry he learned that the mortality among workmen was only five in 100,000. The immunity seems to be in proportion to the relative amount of fine copper (copper powder) which the men can inhale. "Jour. de Med., fie.," Ibid. |
Ossification of the whole Muscular System. A curious case of this sort is reported by Dr. Byers, of Texas. A healthy child of eight years had small tumors appear on the surface of his body; they gave no pain, and in a year and a-half , but were followed by anchylosis of the joints.and a slow deposit of ossific matter in the muscles. Nearly all the muscles became hard and useless. lie did not increase in stature after his tenth year, and never manifested signs of virility. He died at seventeen, never having suffered pain. The language of Dr. B. is such, that we are left in doubt as to whether the deposit was really a calcification, a deposit of earthy salts, or whether it had the characteristics of true bone tissue. Ibid. |
in 11 it i a I ub r a it s 1 a 11 n n h A NEW REMEDY FOR CATARRH. A recent number of the Heilbronn Memorabilien, (Germany,) contains the following resume of an article on the nature and treatment of Catarrh, by Dr. M. Frank, of Munich. Nasal Catarrh should always be regarded as an infectious disease. The infectious principle is chiefly transmitted to the nasal passages in the air of respiration, which very soon its action in a profuse watery secretion from th'e mucous surfaces. The affection is then propagated along the lachrymal ducts to the conjunctival membrane, into the pharynx, tubes, larynx, trachea and bronchial tubes, with the accompanying train of symptoms in these organs; or the may extend down the oesophagus, into the stomach and intestinal tract, with the corresponding morbid phenomena. In most instances, where the intensity is not great', it runs its course in from seven to eleven days. With many the febrile state, sense of weakness, and feeling of discomfort generally are so great that the patient will take to his bed, or the of continual cleansing of the nostrils, or sometimes the just appreciation of the danger to others, will cause him, for the time being, to avoid all society. The constant neglect of colds, or ordinary catarrh, on account of its being regarded a trivial affection, is a matter of daily observation, and which led Ilufeland to assert that a greater number of people died of it than from the pest. Dr. Frank recommends the following treatment, which he has practiced for two years, with constantly favorable results: Immediately on the approach of the first symptoms in the nasal passages the patient is directed to use a weak solution of the hypermanganate of soda as a disinfectant. Enough of the hypermanganate is added to a goblet full of water to give it a cherry red color. A handful of this solution is snuffed up the nostrils every couple of hours, using the precaution to blow out carefully after each operation. If the pharynx has become affected, the same should also be used as a gargle. Usually before the end of the second day all symptoms have disappeared. E. 0. F. 11. |
wDirrsuu iiui'iin Prof. Davis: Is it true that the practice of homoeopathy is interdicted in Russia? Some months ago, I read a statement in some of our medical journals, that the Emperor of Russia, after giving a fair and impartial trial, for three years, in hospitals set apart for that purpose, in St. Petersburg, had issued a decree that homoeopathy should not be practiced in any of the of Russia, under penalty of fine and imprisonment. Will you be kind enough to give us the truth of this matter, in as full a manner as possible, and oblige mapy who wish to use this fact as a climax, and as a clincher to our anti-homoeopathic arguments, with the deluded admirers of the similia similibus curantur vaguery, the champion system of small ideas in their narrowness and of small doses, microscopic in their dimensions. Yours, truly, THEODORE GRIFFIN, M.D., 582 South State Street. |
A Placenta Previa and Double Births is recorded by Dr. Maquida, of Mississippi, in which the mother and both children were saved. The first child presented by the breech, and crowded aside the placenta without wholly detaching it from the uterine walls; it was a small child. The second presented by the occiput, forcing down the placenta and directly occluding the os. With a little assistance the placenta was wholly detached from the uterine walls, and the delivery with no excessive hemorrhage. W. 0. Med. Jour. |
Physicians and Druggists in America. Dr. A. B. , of Ann Arbor, Michigan, states that there were 55,000 physicians in this country at the last census, and 11,000 . At present there are about 74,000 physicians. |
Dr. Edward Lawson (Practitioner^ says, the sulpho-carbolates are not powerful direct antiseptics; they are far less powerful than carbolic acid; half a grain of pure acid is equal to twenty grains of sulpho-carbolate of sodium. Not only is the salt as compared with the acid far less efficient in destroying the life of vegetable cells, but the acid loses in this power by combination with the base ; i. e., one grain of the acid, when free, is as efficient as twenty times that amount in combination. But these salts can be readily without difficulty or danger; in transitu throughout the the carbolic acid becomes evolved, producing its effect. In the sulpho-carbolate we are enabled in effect to administer carbolic acid in an innocuous form, and in larger quantity than otherwise possible. The sulpho-carbolate of zinc has been used as an external in the form of lotion. Ten grains should be dissolved in an ounce of distilled water. It abolishes the fetor of pus-forming , and is superior to carbolic acid on account of the absence of irritating qualities, and of all unpleasant odor. For internal use, the sulpho-carbolate of sodium is preferable; its solution in water has no unpleasant taste. The dose is 20 to 60 grains. Given in phthisis, while it has no power to arrest the disease, there was a steady gain in nutrition; in many cases the strength increased, rest improved, the fetor of expectoration wTas arrested, the night sweats decreased, and the appetite improved. I employed it in five cases of severe tonsillar ulceration, which all rapidly recovered without suppuration. Half-Yearly Compend. |
Form of Neuralgia of the Jaw-Bones Hitherto . (2?y PS D. Gross, M.D., Prof. Surgery, etc.") The seat of this affection is in the remnants pf the alveolar process of person's, or in the alveolar structures of the overlying gums, and occurs mainly in elderly persons. It occurs most often in the upper jaw, and usually affects but a small extent of surface. The soft tissues in the immediate vicinity do not seem to suffer as in ordinary neuralgia, save in a slight degree. The morbid action is generally limited to the bone, although the gum may be, in rare instances, involved. The gum is nearly always hard and dense, grating under the knife, and adhering with great firmness to the atrophied alveolar process beneath. The pain is generally paroxysmal, as in ordinary neuralgia, the slightest causes provoking it, as talking, masticating, the contact of hot or cold fluids, deglutition, or mental excitement. Sometimes it is momentary, occasionally it lasts for hours, and a few cases occur in which it continues with little mitigation for an indefinite period. The pain varies in character, and pressure relieves rather than aggravates it. The pathology of the affection seems to be compression of the minute nerves distributed through the wasted alveolor process, dependent upon the encroachment of osseous matter upon the walls of the canals in which they are naturally enclosed. The osseous structure is always abnormally hard from the deposit of new which imparts to it an almost ivory-like consistence. The disease usually comes on gradually, growing worse, until the suffering is intolerable. The general health becomes eventually impaired, the appetite deranged, the sleep disturbed, the anxious, digestion imperfect, bowels constipated, and the spirits much depressed. Sometimes the disease would seem to be of origin, the attacks coming on periodically. The professor gives a history of six cases which illustrate this disease, and the he institutes for its relief. The treatment consists in carrying an incision along the alveolar ridge over the painful structures, dividing and turning aside the soft parts, including the periosteum, and removing, by means of cutting pliers (constructed for the purpose), and the gouge, the affected bone to a level with the palatine process. He has not found the bone at all diseased, and, from all his , recovery has been both prompt and complete. Am. Journal of Medical Science. |
Correction. The case of Ovariotomy reported in the September number of Tiie Examiner, and credited to "M. A. Chase, M.D., of Siruoza, Wis.," should have been credited to H. A. Chase, of Viragua, Wis. In the record of proceedings of the Illinois State Medical Society, the name of Dr. 0. Everett, of Dixon, is printed Dr. 0. Evarts, and that of Dr. George W. Hewett, of Franklin Grove, is made to read George W. Heath. We have read manuscript for many years, but we continue occasionally to misinterpret the names of both men and places. |
Catarrh of the Uterus. Dr. G. W. Hamilton, writing on this disease in the Buffalo Med. and Surgical Journal, claims that its pathology consists in dilation of the capillaries and congestion of the lining of the uterus. When there is no ulceration, he advocates the use in addition to good hygiene, and such medicines as will regulate the bowels and secretions, and improve the digestion and general health of injections of persulphate of iron, of the strength of 24 grs. to the half-pint of water, and the internal use of ergot in moderate doses for several weeks continuously. The ergot operates by increasing the tonicity of the capillary bloodvessels of the uterus, the circulation and removing the congestion. Ergot does not retard the circulation unless given continuously and in large doses; it may be given a long time in proper medicinal doses, without any bad effect whatever. |
Bromide of Potassium in Its Effect on Children. E. Montard-Martin, of the Beaujou Hospital, France, reports a number of cases to show the effects of this drug on infants and small children. It is invaluable in all cases of dentition, where there are aggravating nervous symptoms, and it is improper to give opium. In sleeplessness of infants, in cough purely , he gives it in doses of gr. once or twice a day to children from three months to a year old. In purely nervous cough it is equally indicated; but it should not be given in diarrhoea, as it increases this difficulty. In excessive erethism of any sort, and especially in those cases of boys where there is almost constant erection of the penis, it works most happily. When administered to infants, the breast should be given at once afterwards. New York Medical Journal. |
Double Salts of Carbolic Acid. The difficulties in the administration of carbolic acid have peen overcome in the discovery and employment of salts of the sulpho-carbolic acid (CgHeS O4) with the alkaline, earthy and metallic bases. The first compound salt, the sulpho-carbolate of potash, was obtained by Crooks. Dr. Sansom has produced in addition the following salts, all having the character of true double salts, and possessing brilliancy and decidedly crystalline forms: sulpho-carbolate of sodium, of pot., of ammonium, of magnesium, of zinc, of copper, and of iron. An inquiry instituted with a view of determining the relative of the various salts in staying fermentative action, the following results; 1, the sodium salt; 2, magnesium ; 3, potassium; 4, ammonium. It has been shown, from experiments upon the lower animals, as well as from the results of to the human subject, that the following is an outline of the plan of action of the sulpho carbolates: They are absorbed with great rapidity, exert no toxic effect (the human subject readily drachm doses every four hours), are decomposed in the system into a, carbolic acid which, traversing the system, is exhaled by the breath ; &, sulphate of soda, which permeates the tissues after death. It is shown that an influence, enabling the body to resist , has been exerted; the urine passed also resists decomposition. Prolonged courses of sulpho-carbolate of sodium, given for two months to phthisical patients, show that the drug could be not only with impunity, but with considerable advantage. Of 35 cases, 13 greatly improved; 15 considerably improved; and 9 cases gained in weight an average of 2^ pounds. Med,. Times and Gazette, Half-Yearly Com. |
Veratrum Virida in Pneumonia. Dr. T. M. Woodson, in the American Practitioner, strongly advocates the use of in pneumonia. He gives a history of four cases in which he used it in six to seven drop doses every three or four hours, with large doses of Dover powder, and sometimes calomel. Some of these cases were very severe, the pulse reaching 132, with the temperature 105deg, and respiration over 30. The drug brought down the pulse promptly, sometimes with and purging, but safely, to from 55 to 70 per minute; the temperature and respiration were proportionally reduced, and convalescence was speedily established. The doctor has this practice for many years, with fine success. The works more kindly in conjunction with opium, and these two agents he places at the head of all remedies for the active stage of pneumonia. |
Humulus Lupulus in Intermittent Fever. Dr. W. Y. Godberry, of Benton, Miss. [The Jour. Materia Medico), the anti-periodic power of humulus lupulus as equal to that of any other article in the Materia Medica, except quinia, and has often found it to succeed in arresting intermittents after quinia had failed. Medical Record |
On a Rare Disease of th,e Joints. Dr. Samuel Jackson, Emeritus Professor, etc., gives an account of several cases that have fallen under his observation, of a rare form of disease resembling rheumatoid arthritis, if they are not examples of this affection. The peculiarity of the malady is, that it is confined to a single tissue the ligamentous the general health of the patient not being disturbed. So far as his cases indicate the character of the disease, it seems to continue for years, to be incurable, but to have no direct tendency to cause death. In one case in which the joint of the wrist and hand was the one affected, all the bones were dislocated. In another, both wrists were dislocated at every movement. It was evident that the cartilage had disappeared, and that the bones had become smooth by friction upon each other. A third case had every joint dislocated and stiffened; yet the health was good, and the patient lived for years with no pain save on an attempt at motion. One patient traveled extensively, and received the best care and treatment for ten years. " During all this time the disease progressed, stiffening the joints, until she became incapable of motion, and had to be carried about, fed like a child, and waited upon. And yet her general health is perfect, and has always been so ; her organic functions are unimpaired, and her spirits are not affected." American Journal of Medical Science. |
The Force of Uterine Contraction. The extreme force of uterine contraction produces a pressure of 3,402 lbs. per square inch, which is equivalent to a pressure of 54-106 lbs, acting upon a circle of 9| inches in diameter, which is assumed as the average area of the pelvic canal. The maximum force used to expel the foetus, by both uterine and abdominal muscles combined, is estimated by Soulin, by forceps experiments made on the dead body, at 110.23 lbs., a result which is regarded by Dr. Duncan as too large. Dr. Duncan considers 80 lbs. as the maximum force ever employed in difficult cases. This would correspond with an hydrostaticol pressure inside the uterus of 5.05 lbs. per square inch, which is greater than the uterine , unaided, are capable of producing. Dublin Quarterly Journal Medical Sciences. |
A NEW ANTISEPTIC. The hydrated chloride of aluminium, to which Mr. John Gambee has recently drawn the attention of medical men and the general public, appears to be a valuable antiseptic. It is quite as potent as chloride of zinc or carbolic acid, and is at the same time non-poisonous, and devoid of unpleasant smell of every kind. These qualities will no doubt ensure its being used,, and at no distant date we may expect it to the antiseptics which are at present in vogue. It is somewhat strange that this substance should have been so long overlooked as a possible antiseptic, and Mr. Gamgee certainly deserves credit for suggesting the utilization of it for this purpose. The reason why it has been passed over is to be sought in its not being a waste product in any chemical manufacture. The anhydrous chloride aluminium, which is manufactured in order to serve for the preparation of metallic aluminium, is far too costly on account of the nature of the process by which it is prepared to-wit, by passing chlorine at high temperatures over a mixture of and charcoal. By placing the anhydrous chloride of alumnium in water, it is of course converted into hydrated . The most economical process for the preparation of the hydrated chloride of aluminium appears to be by double between sulphate of alumina and chloride of (both of which are cheap commercial products.) When solutions of these two salts are mixed together, sulphate of lime is formed and appears as a precipitate, whilst the hydrated chloride of aluminium remains dissolved. On allowing the aqueous solution to evaporate at a very gentle heat and afterwards cooling, crystals of hydrated chloride are produced. If an attempt be made to drive off the water from the hydrated chloride by the application of heat, decomposition will take place. Hydrochloric acid is evolved under these conditions, and oxy-chloride of aluminium is formed, and, by pushing the process, alumina is obtained as the ultimate fixed product. Lancet. |
Asylum Schools for the Insane. Several of the public of Europe have for many years past had, to their ordinary treatment of lunatics, the addition of a well-ordered school, in which patients are instructed in the various fundamental branches of a common school education, as in any of our public schools. This practice has never been introduced into the American asylums. The system, by those who practice it, is said to work admirably. Of course it is not expected that lunatics will deport themselves or make progress in their studies like sane persons, but they are found to invariably take to the school exercises, not merely with willingness, but with real enthusiasm; and it furnishes a diversion for the mind, a new exercise with which to amuse and entertain patients, which is found very beneficial to the particular class of invalids. As might be expected, the amount of real knowledge gained by these people, to be carried with them when discharged, is small; but the object of the system is more to amuse, divert, and exercise the mind of the patient; it is an exercise, by the use of which only, says one of the superintendents, "what may be called the moral treatment can be fully carried out." American Journal of Insanity. |
A sketch ot the Ji arty History ot JL r<ictical Ancitoniy. -t^y '' * W. Keen, M.D., Lecturer on Anatomy and Operative , Philadelphia School of Anatomy; Lecturer on Anatomy in Jefferson Medical College. This is a peculiarly happy, interesting and instructive , presented in the form of an introductory address. The writer calls us back to the first efforts to advance the science of Anatomy, which was in the city of Alexandria, about 300 years before Christ, Egypt then being the medical centre for the whole world. All the great men of the world repaired to Egypt for instruction. Galen went from Rome to Egypt to see a human skeleton, the practise of burning the bodies at Rome prohibiting the study of practical anatomy on the human . With the fall of Alexandria, the science of Anatomy declined, and was not known for a period of twelve centuries, when it W'as again revived in Italy, at the city of Bologne. Italy now became the centre of learning for the whole world, and at the famous University of Bologne, there were 10,000 students assembled; here the first modern dissection was . Notwithstanding the fame which the Italian schools had acquired, they, also, declined. And, with the sixteenth century, came a new impulse. Vesalius became teacher of in Padua, in 1537, and from then we have, successively, Columbus, Eustachius, Falopius, Fabricus, Gassier, Ingrassias, Araetius, Vesalius, Varolius, and the names of many other anatomists. The author tells us of many of the difficulties with which the Eastern anatomists had to contend, and of the total ignorance of many professed physicians of the science. He traces the history of dissections down from Italy to England, and giving its history in England, Scotland, and Holland, alluding to all the distinguished anatomists of those days and countries. The limits of a review render it to do justice to the merits of this valuable essay. It is to be lamented that no work on the history of Anatomy has yet appeared in American medical literature, and, for this fact, the essay of Dr. Keen is peculiarly valuable, as including many facts relative to the history of the science, carefully gathered and arranged. H. W. B. |
The Physiological Effect of Muscular Exercise. In some remarks on this subject recently made before a medical society in New York, Dr. Austin Flint, Jr., stated that there is an increased quantity of excrementitious matter produced in the system on muscular exertion. Some recent experiments seem to throw doubt on this statement, but he thought their results were not correct. Within physiological limits, the elimination of this excess of effete matter is attended, if proper nutriment be supplied, by nutrition. If a man in health, eating and drinking to a correct appetite, exercise his muscular system so as to to its highest point the elimin ition of effete matter, he will correspondinly increase the nutrition of his muscular system. If we can thus develop the muscular system the rest of the body will share in the improvement. Can a man by such exercise successfully combat the tendency to deposits in his tissues, to the formation of tubercles? Dr. F. thought such was possible; he had seen consumptives, with tubercles already formed, go to the gymnasium and become hale and robust. He knew one case in particular where the patient became an accomplished gymnast after tubercles had been clearly diagnosed in his lungs. It would seem that these men might by increasing the deposit of normal material, have removed the to the deposit of that which is abnormal. Let a man moderately healthy, work as hard as he pleases with his brain if only he take the appropriate exercise to keep the throwing off the effete matter, and appropriating in its place, healthy nitrogenized functioning matter, he will be comparatively safe. It is better by constant exercise to keep ourselves healthy, than to break down every few months and have to take a vacation to recruit again. 2V. Y. Medical Journal. |
Dislocation of three Cervical Vertebrae Reduction and Recovery. Dr. Theodore Myers, of Belleville, Ill., reports a case in which he avows this very remarkable set of circumstances took place. A patient, a large man, was accidentally caught by his clothing upon a shaft in a mill, which revolved at the rate of sixty times per minute; he was rolled up backwards and the shaft made a good many revolutions before it could be stopped. Two hours after the accident, Dr. Myers found' the patient lying upon his back, with his head twisted to the left, the third, fourth, and fifth cervical vertebrae dislocated laterally, and at the same time so rotated upon their axis that the spinous processes occupied a nearly lateral position. There was a knoll-like projection into the curve of the neck, on the right side, above the shoulder, which proved to be the head of the humerous dislocated, forwards and ; the left arm and both lower extremities were almost paralyzed. An assistant was instructed to make gentle traction upon the head, and the doctor, by slight pressure upon the spinous processes of the vertebrae and rotation at the same time, was enabled' to effect the reduction of the displaced bones Both the patient and the "heard and felt," distinctly, the snapping of the bones as they were replaced. The head at once recovered its proper position and mobility. Complete recovery took place in two or three weeks. St. Louis Medical and Surgical Journal. |
Correction. In the November number of the Examiner, on page 676, line 17, the word morbid should be normal. To Subscribers. The present number completes the Volume of the Examiner. Recently, bills have been sent to all who stand on our books indebted for one year or more. During the past year, our time has been so occupied, we have been compelled to allow the book's of the Examiner to be kept by a clerk, and it is probable some mistakes have been made. We shall cheerfully make any corrections that our subscribers may point out. We shall commence the new volume with more reliable and steady assistance, and hope to receive the same friendly patronage as heretofore. We shall continue to make the Examiner strictly a periodical, devoted to the interests of the medical profession, and not an advertising sheet for and medicine manufacturers. (TO H 11 U I It 1 |
On the Use of Bromide of Lithium. Dr. S. Weir Mitchell in experimenting on the various bromides, finds that the bromide of lithium produces the characteristic action more promptly than any of the other preparations. This salt is very deliquescent and should be given in solution. It contains nearly 92 per cent, of bromine, while the salt of potassium has but 66 per cent., and that of sodium only 72 per cent. This new salt seems to act efficiently in some cases of epilepsy where the bromide of potassium has failed. It is efficient in lesser doses than the latter salt, and as an hypnotic it is superior to all the other bromides. He gives a brief history of its use in several cases of epilepsy, where, after treatment with other bromine salts, this was substituted with the effect to produce more profound effect in smaller doses; in one or two cases it seems to have had some control over the disease where the other salts had entirely failed. Bromide of lithium is less unpleasant than that of potassium, but more so than that of sodium; it is at present much more expensive than either, but if the consumption of it was great it could be at a much, lower rate. American Journal Medical Science. |
Therapeutic Effects of Gelseminum. Dr. E. A. Anderson, of North Carolina, experimented very extensively during the war with the Gelseminum, in his efforts to find some agent that would serve the purpose of quinine in intermittent and remittent fevers. He now uses this agent the Gelseminum almost exclusively in intermittents, especially in children, to whom it is especially , from its absence of any of the unpleasant taste of quinine; he has seldom been disappointed in its effects. He employs the (.jiv. bruised root to Oi. alcohol) or the fluid extract of . Dose in the proportion of twenty drops to an adult. It should, like quinine, be given before the expected paroxysm four to six doses should be given before its onset is expected. He says, "I have found it a reliable agent in intermittent, and typhoid fevers; acute and chronic rheumatism; in of the lungs, pleura, and pneumonia. I have, for several years, used it almost exclusively in pneumonia, in place of veratrum, and consider it the best agent in this disease. You can reduce the force and frequency of the circulation with it, as certainly as by venesection, digitalis, or veratrum, without the distressing effects of these agents, while, at the same time, it allays the morbid heat, restlessness, and irritating cough." Journal Materia Medica. |
The Use of Pepsin. Dr. E. P. Hurd ridicules the idea that pepsin can be of the value as an aid to digestion that many seem to regard it. Most of the substance of the pepsin we use is starch, and in any case, be it never so strong, a scruple of it can only eighty or ninety grains of aliment. Boudault's pepsin only digests about fourtimes its own weight of albumen. How far is our ordinary dose going to help a poor victim of through the solution of an ordinary meal? He strongly suspects that with regard to the real effect of this agent we are very much deceived. Medical and Surgical Journal. |
A Case of Occlusion of the Vagina with Retention of the Catamenia, is reported by Dr. J. B. Mallory, in a woman who had borne five children. After weaning her last child she three months regularly, and then ceased for five months. At this time excessive pains and hemorrhage ensued, and in a short time there was passed from the vagina a fleshy, fibrous mass of the size and form of an egg. The pain then ceased, but returned in slight paroxysms at intervals for five or six months, during which time her menstrual function did not return. Twelve months after cessation of the flow she was attacked with such severe pains in the region of the pelvis that she came to the writer. On examination per vaginum an obstruction was found that completely occluded the canal. The obstruction was diagnosed as an adhesion of the vaginal walls, which had probably taken place after the discharge of the egg-shaped mass. Back of the there was a large tumor, evidently accumulated secretion from the uterus. A small opening was made through the septum, which was found to be an inch and more in thickness, and a tarry fluid flowed out. She continued to improve for about three months, when an occurred in the left iliac region, which passed on to ; subsequently the opposite side became similarly effected, discharging freely for several weeks. The opening through the obstructing septum becoming occluded another opening had to be made subsequently; this was made larger and after some drawbacks the patient recovered her menstrual . JRichmond and Louisville Medical Journal. |
Abdomino-Vaginal Impalement. Dr. W. M. James tells of a case of accident of this character that is both curious and instructive. A woman weighing nearly 200 pounds, climbs a hay-mow in search of eggs; leaping down on a pile of hay, there chances to be a pitchfork projecting, handle upward, upon which she falls. The handle of the fork enters the vagina, plunges through the vaginal wall, making a rupture just at the right of the mouth of the womb and behind it; it passes upward through the abdominal cavity until it strikes the ninth or tenth rib, near the spinal column on the left side. The handle was arrested by the ribs, and held so firmly that the woman was carried over at right angles from the mow, the whole weight bearing on the instrument. After all this violence within the abdominal cavity, the woman made steady improvement and went on to complete recovery. Opium was freely used, and disinfectants to the^vagina. After the vaginal wound healed, an abscess formed in the region of the injured rib, which was opened externally. Journal Society. |
JAMA Netw Open JAMA Netw Open JAMA Network Open 2574-3805 American Medical Association 10.1001/jamanetworkopen.2023.6766 zcx230022 Other Correction Online Only Error in Byline and Author Affiliations Correction 17 3 2023 3 2023 17 3 2023 6 3 e236766Copyright 2023. JAMA Network Open. This is an open access article distributed under the terms of the CC-BY License. jamanetwopen-e236766.pdf pmcIn the Original Investigation titled "Association of Allostatic Load With Overall Mortality Among Patients With Metastatic Non-Small Cell Lung Cancer,"1 published July 7, 2022, Dr Reisinger's surname was misspelled in the byline and author affiliations. This article has been corrected. References 1 Obeng-Gyasi S, Li Y, Carson WE, . Association of allostatic load with overall mortality among patients with metastatic non-small cell lung cancer. JAMA Netw Open. 2022;5 (7 ):e2221626. doi:10.1001/jamanetworkopen.2022.21626 35797043 |
JAMA Netw Open JAMA Netw Open JAMA Network Open 2574-3805 American Medical Association 10.1001/jamanetworkopen.2023.5547 zcx230019 Other Correction Online Only Error in Figure 2 Correction 17 3 2023 3 2023 17 3 2023 6 3 e235547Copyright 2023. JAMA Network Open. This is an open access article distributed under the terms of the CC-BY License. jamanetwopen-e235547.pdf pmcIn the Original Investigation titled "State Cannabis Legalization and Psychosis-Related Health Care Utilization,"1 published January 25, 2023, there were errors in Figure 2. The rate ratios and 95% confidence intervals for the top middle panel, which depicts the rate ratios for psychosis-related claims as a function of state cannabis policy level for women, were depicted incorrectly. The rate ratios for medical with retail outlets should have appeared as 1.20 (95% CI, 0.92-1.56) instead of 1.20 (95% CI, 0.79-1.84); for recreational with no retail outlets, 1.20 (95% CI, 0.79-1.84) instead of 1.36 (95% CI, 0.94-1.98); and for recreational with retail outlets, 1.36 (95% CI, 0.94-1.98) instead of 1.63 (95% CI, 1.09-2.44). This article has been corrected.1 Reference 1 Elser H, Humphreys K, Kiang MV, . State cannabis legalization and psychosis-related health care utilization. JAMA Netw Open. 2023;6 (1 ):e2252689. doi:10.1001/jamanetworkopen.2022.52689 36696111 |
Comput Intell Neurosci Comput Intell Neurosci cin Computational Intelligence and Neuroscience 1687-5265 1687-5273 Hindawi 10.1155/2023/9763172 Retraction Retracted: Clinical Application of Perioperative Anaesthesia Management Based on Enhanced Recovery after Surgery Concept to Elderly Patients Undergoing Total Knee Replacement Intelligence and Neuroscience Computational [email protected] 2023 12 3 2023 12 3 2023 2023 97631729 12 2022 9 12 2022 Copyright (c) 2023 Computational Intelligence and Neuroscience. 2023 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. pmc Computational Intelligence and Neuroscience has retracted the article titled "Clinical Application of Perioperative Anaesthesia Management Based on Enhanced Recovery after Surgery Concept to Elderly Patients Undergoing Total Knee Replacement" due to concerns that the peer-review process has been compromised. Following an investigation conducted by the Hindawi Research Integrity team , significant concerns were identified with the peer reviewers assigned to this article; the investigation has concluded that the peer-review process was compromised. We therefore can no longer trust the peer-review process, and the article is being retracted with the agreement of the Chief Editor. 1 Zhang J. Che J. Sun X. Ren W. Clinical Application of Perioperative Anaesthesia Management Based on Enhanced Recovery after Surgery Concept to Elderly Patients Undergoing Total Knee Replacement Computational Intelligence and Neuroscience 2022 2022 6 8039358 10.1155/2022/8039358 2 Ferguson L. Advancing Research Integrity Collaboratively and with Vigour 2022 |
Front Pediatr Front Pediatr Front. Pediatr. Frontiers in Pediatrics 2296-2360 Frontiers Media S.A. 10.3389/fped.2023.1172723 Pediatrics Erratum Erratum: A tailored passive driver for liver MRE in pediatric patients Frontiers Production Office* Frontiers Media SA, Lausanne, Switzerland Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland * Correspondence: Frontiers Production Office [email protected] Specialty Section: This article was submitted to Pediatric Gastroenterology, Hepatology and Nutrition, a section of the journal Frontiers in Pediatrics 06 3 2023 2023 06 3 2023 11 117272323 2 2023 23 2 2023 (c) 2023 Frontiers Production Office. 2023 Frontiers Production Office This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. pediatric MRE Liver stiffness patient-specific vibrational excitation toroidal passive driver MRE workflow pmcAn Erratum on A tailored passive driver for liver MRE in pediatric patients By Lorton O, Toso S, El-Begri Talbi H, Anooshiravani M, Poletti P, Hanquinet S and Salomir R (2022) Front. Pediatr. 10:999830. doi: 10.3389/fped.2022.999830 An omission to the funding section of the original article was made in error. The following sentence has been added: "Open access funding was provided by the University of Geneva". The original version of this article has been updated. |
Front Plant Sci Front Plant Sci Front. Plant Sci. Frontiers in Plant Science 1664-462X Frontiers Media S.A. 10.3389/fpls.2023.1170080 Plant Science Erratum Erratum: Vessels in a Rhododendron ferrugineum (L.) population do not trace temperature anymore at the alpine shrubline Frontiers Production Office * Frontiers Media SA, Lausanne, Switzerland Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland *Correspondence: Frontiers Production Office, [email protected] This article was submitted to Functional Plant Ecology, a section of the journal Frontiers in Plant Science 06 3 2023 2023 06 3 2023 14 117008020 2 2023 20 2 2023 Copyright (c) 2023 Frontiers Production Office 2023 Frontiers Production Office This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. An Erratum on Vessels in a Rhododendron ferrugineum (L.) population do not trace temperature anymore at the alpine shrubline by Piccinelli S, Francon L, Corona C, Stoffel M, Slamova L and Cannone N (2023) Front. Plant Sci. 13:1023384. doi: 10.3389/fpls.2022.1023384 alpine shrub dendroecology wood anatomy climate-growth relations climatic signal loss pmcAn omission to the funding section of the original article was made in error. The following sentence has been added: "Open access funding was provided by the University of Geneva". The original version of this article has been updated. |
poster was presented at the Pakistan Society for the Study of Liver Diseases and at the 23rd National Health Sciences Research Symposium as speaker. Grant Support & Financial Disclosures: None. |
Front Immunol Front Immunol Front. Immunol. Frontiers in Immunology 1664-3224 Frontiers Media S.A. 10.3389/fimmu.2023.1170106 Immunology Erratum Erratum: Human pegivirus-1 replication influences NK cell reconstitution after allogeneic haematopoietic stem cell transplantation Frontiers Production Office * Frontiers Media SA, Lausanne, Switzerland Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland *Correspondence: Frontiers Production Office, [email protected] This article was submitted to NK and Innate Lymphoid Cell Biology, a section of the journal Frontiers in Immunology 06 3 2023 2023 06 3 2023 14 117010620 2 2023 20 2 2023 Copyright (c) 2023 Frontiers Production Office 2023 Frontiers Production Office This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. An erratum on Human pegivirus-1 replication influences NK cell reconstitution after allogeneic haematopoietic stem cell transplantation. By Pradier A, Cordey S, Zanella M-C, Melotti A, Wang S, Mamez A-C, Chalandon Y, Masouridi-Levrat S, Kaiser L, Simonetta F and Vu D-L (2023) Front. Immunol. 13:1060886. doi: 10.3389/fimmu.2022.1060886 human pegivirus-1 NK cell transplantation stem cell CD16 granzyme B CD57 pmcAn omission to the funding section of the original article was made in error. The following sentence has been added: "Open access funding was provided by the University of Geneva". The original version of this article has been updated. |
Front Psychol Front Psychol Front. Psychol. Frontiers in Psychology 1664-1078 Frontiers Media S.A. 10.3389/fpsyg.2023.1170276 Psychology Erratum Erratum: Influence of bodily resonances on emotional prosody perception Frontiers Production Office * Frontiers Media SA, Lausanne, Switzerland Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland *Correspondence: Frontiers Production Office [email protected] This article was submitted to Emotion Science, a section of the journal Frontiers in Psychology 06 3 2023 2023 06 3 2023 14 117027620 2 2023 20 2 2023 Copyright (c) 2023 Frontiers Production Office. 2023 Frontiers Production Office This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. An Erratum on Influence of bodily resonances on emotional prosody perception by Selosse, G., Grandjean, D., and Ceravolo, L. (2022). Front. Psychol. 13:1061930. doi: 10.3389/fpsyg.2022.1061930 emotional prosody perception embodiment bodily resonances interoception pmcAn omission to the funding section of the original article was made in error. The following sentence has been added: "Open access funding was provided by the University of Geneva." The publisher apologizes for this mistake. The original article has been updated. |
Hum Mol Genet Hum Mol Genet hmg Human Molecular Genetics 0964-6906 1460-2083 Oxford University Press 10.1093/hmg/ddac294 ddac294 Original Article AcademicSubjects/SCI01140 Correction to: Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease 01 4 2023 22 12 2022 22 12 2022 32 7 12361236 25 10 2021 1 2 2022 6 2 2022 (c) The Author(s) 2022. Published by Oxford University Press. 2022 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. pmcThis is a correction to: Richard G Lee, Shanti Balasubramaniam, Maike Stentenbach, Tom Kralj, Tim McCubbin, Benjamin Padman, Janine Smith, Lisa G Riley, Archana Priyadarshi, Liuyu Peng, Madison R Nuske, Richard Webster, Ken Peacock, Philip Roberts, Zornitza Stark, Gabrielle Lemire, Yoko A Ito, Care4Rare Canada Consortium, Kym M Boycott, Michael T Geraghty, Jan Bert van Klinken, Sacha Ferdinandusse, Ying Zhu, Rebecca Walsh, Esteban Marcellin, David R Thorburn, Tony Roscioli, Janice Fletcher, Oliver Rackham, Frederic M Vaz, Gavin E Reid, Aleksandra Filipovska, Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease, Human Molecular Genetics, Volume 31, Issue 21, 1 November 2022, Pages 3597-3612, In the originally published version of this manuscript, the names of authors Tony Roscioli and Ying Zhu were inadvertently misspelled. These errors have been corrected online. |
has been updated. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Change history 7/26/2023 A Correction to this paper has been published: 10.1186/s12987-023-00456-x |
Sao Paulo Med J Sao Paulo Med J Sao Paulo Med J Sao Paulo Medical Journal 1516-3180 1806-9460 Associacao Paulista de Medicina - APM 10.1590/1516-3180.2017.0023190317errata Erratum ERRATUM 21 8 2017 2017 21 8 2017 135 5 508508 (c) 2022 by Associacao Paulista de Medicina 2022 Associacao Paulista de Medicina This is an open access article distributed under the terms of the Creative Commons license. pmcIn the paper "Physical activity in Brazil: lessons from ELSA-Brasil. Narrative review", with DOI number 10.1590/1516-3180.2017.0023190317, published in the Sao Paulo Medical Journal, volume 135, issue number 4, pages 391-5, on page 391: Where it read: "IVMD, PhD. Full Professor, Institute of Public Health, Universidade Federal da Bahia (UFBA), Salvador (BA), Brazil." It should read: "IVMD, PhD. Full Professor, Instituto de Saude Coletiva, Universidade Federal da Bahia (UFBA), Salvador (BA), Brazil." |
MMWR Morb Mortal Wkly Rep MMWR Morb Mortal Wkly Rep WR Morbidity and Mortality Weekly Report 0149-2195 1545-861X Centers for Disease Control and Prevention 36928408 mm7211a7 10.15585/mmwr.mm7211a7 Quick Stats QuickStats: Age-Adjusted Drug Overdose Death Rates,*,+ by State National Vital Statistics System, United States, 2021 Reported by: Arialdi M. Minino, MPH, [email protected]; Merianne R. Spencer, MPH. 17 3 2023 17 3 2023 72 11 293293 All material in the MMWR Series is in the public domain and may be used and reprinted without permission; citation as to source, however, is appreciated. pmcIn 2021, the U.S. age-adjusted drug overdose death rate was 32.4 per 100,000 population. The highest rates were in West Virginia (90.9) and the District of Columbia (63.6); the lowest rates were in the Upper Midwest and Texas. The lowest state rates were those in Nebraska (11.4), South Dakota (12.6), and Iowa (15.3). Source: National Center for Health Statistics, National Vital Statistics System, Mortality Data. For more information on this topic, CDC recommends the following link: * Deaths per 100,000 standard population. Age-adjusted drug overdose death rates were calculated using the direct method and the 2000 U.S. Census Bureau standard population. In 2021, the age-adjusted drug overdose death rate was 32.4 per 100,000 standard population. + Drug overdose deaths were identified using International Classification of Diseases, Tenth Revision underlying cause-of-death codes X40-X44, X60-X64, X85, and Y10-Y14. |
Prehosp Disaster Med Prehosp Disaster Med PDM Prehospital and Disaster Medicine 1049-023X 1945-1938 Cambridge University Press New York, USA S1049023X23000158 10.1017/S1049023X23000158 Corrigendum Health Status and Disaster Resilience. A Socio-Health Approach to Improve Local Disaster Resilience and Contain Secondary Crises: A Case Study in an Agricultural Community Exposed to Bushfires in Australia - CORRIGENDUM Cuthbertson Joseph Archer Frank Robertson Andy Rodriguez-Llanes Jose 4 2023 08 2 2023 08 2 2023 38 2 282282 (c) The Author(s) 2023 2023 The Author(s) This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence ), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. doi: 10.1017/S1049023X22002436, Published by Cambridge University Press, 6 January 2023. pmcIn the original publication of this article, authors Frank Archer and Jose Rodriguez-Llanes were listed with incorrect post-nominals. This has since been corrected in the original article. Reference Cuthbertson, J. , Archer, F. , Robertson, A. , & Rodriguez-Llanes, J. (2023). A Socio-Health Approach to Improve Local Disaster Resilience and Contain Secondary Crises: A Case Study in an Agricultural Community Exposed to Bushfires in Australia. Prehospital and Disaster Medicine, 38 (1 ), 3-10. doi: 10.1017/S1049023X22002436 |
Front Oncol Front Oncol Front. Oncol. Frontiers in Oncology 2234-943X Frontiers Media S.A. 10.3389/fonc.2023.1159770 Oncology Erratum Erratum: A comparison study between CNN-based deformed planning CT and CycleGAN-based synthetic CT methods for improving iCBCT image quality Frontiers Production Office * Frontiers Media SA, Lausanne, Switzerland Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland *Correspondence: Frontiers Production Office, [email protected] This article was submitted to Radiation Oncology, a section of the journal Frontiers in Oncology 07 3 2023 2023 07 3 2023 13 115977006 2 2023 06 2 2023 Copyright (c) 2023 Frontiers Production Office 2023 Frontiers Production Office This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. An Erratum on A comparison study between CNN-based deformed planning CT and CycleGAN-based synthetic CT methods for improving iCBCT image quality. By Yang B, Chang Y, Liang Y, Wang Z, Pei X, Xu X G and Qiu J (2022) Front. Oncol. 12:896795. doi: 10.3389/fonc.2022.896795 iCBCT registration sCT generation pelvic CycleGAN pmcDue to a production error, there was an error in affiliation 1. Instead of "Department of Radiation Oncology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China", it should be "Department of Radiation Oncology, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China". The publisher apologizes for this mistake. The original version of this article has been updated. |
JAMA Netw Open JAMA Netw Open JAMA Network Open 2574-3805 American Medical Association 10.1001/jamanetworkopen.2023.6719 zcx230021 Other Correction Online Only Errors in Axis Labels in Figures Correction 20 3 2023 3 2023 20 3 2023 6 3 e236719Copyright 2023. JAMA Network Open. This is an open access article distributed under the terms of the CC-BY License. jamanetwopen-e236719.pdf pmcIn the Research Letter titled "Rates of Bilateral Mastectomy in Patients With Early-Stage Breast Cancer,"1 published January 18, 2023, there were errors in the labels of the y-axes in Figure 1 and Figure 2. Both axes are labeled "BCS rate, %." The y-axis label for Figure 1 should have read "Surgery rate, %." The y-axis for Figure 2 should have read "BM rate, %." This article has been corrected.1 Reference 1 Fefferman M, Nicholson K, Kuchta K, Pesce C, Kopkash K, Yao K. Rates of bilateral mastectomy in patients with early-stage breast cancer. JAMA Netw Open. 2023;6 (1 ):e2251348. doi:10.1001/jamanetworkopen.2022.51348 36652251 |
Oncol Lett Oncol Lett OL Oncology Letters 1792-1074 1792-1082 D.A. Spandidos 10.3892/ol.2023.13756 OL-25-4-13756 Retraction [Retracted] RNA interference-mediated USP22 gene silencing promotes human brain glioma apoptosis and induces cell cycle arrest Li Zhao Hui Yu Yin Du Chao Fu Hong Wang Jian Tian Yu 4 2023 13 3 2023 13 3 2023 25 4 170Copyright: (c) Li et al. 2023 This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. pmcOncol Lett 5: 1290-1294, 2013; DOI: 10.3892/ol.2013.1188 Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the cell cycle plots shown in Fig. 5A, and western blotting data in Fig. 6A, on p. 1293 were strikingly similar to data appearing in different form in other articles by different authors at different research institutes. Owing to the fact that the contentious data in the above article had already been published, or were already under consideration for publication, elsewhere prior to its submission to Oncology Letters, the Editor has decided that this paper should be retracted from the Journal. After having been in contact with the authors, they did not agree with the decision to retract the paper. The Editor apologizes to the readership for any inconvenience caused. |
Front Robot AI Front Robot AI Front. Robot. AI Frontiers in Robotics and AI 2296-9144 Frontiers Media S.A. 1173498 10.3389/frobt.2023.1173498 Robotics and AI Erratum Erratum: Transient bio-inspired gliders with embodied humidity responsive actuators for environmental sensing Frontiers Production Office 10.3389/frobt.2023.1173498 Frontiers Production Office * Frontiers Media SA, Lausanne, Switzerland Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland *Correspondence: Frontiers Production Office, [email protected] This article was submitted to Bio-Inspired Robotics, a section of the journal Frontiers in Robotics and AI 07 3 2023 2023 07 3 2023 10 117349824 2 2023 24 2 2023 Copyright (c) 2023 Frontiers Production Office. 2023 Frontiers Production Office This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. An Erratum on Transient bio-inspired gliders with embodied humidity responsive actuators for environmental sensing by Wiesemuller F, Meng Z, Hu Y, Farinha A, Govdeli Y, Nguyen PH, Nystrom G and Kovac M (2022). Front. Robot. AI 9:1011793. doi: 10.3389/frobt.2022.1011793 biodegradable materials transient robotics environmental sensing aerial robotics bio-inspiration pmcAn omission to the Funding section of the original article was made in error. The following sentence has been added: "Open access funding was provided by Empa - Swiss Federal Laboratories For Materials Science And Technology." The original version of this article has been updated. |
BJPsych Bull BJPsych Bull BJB BJPsych Bulletin 2056-4694 2056-4708 Cambridge University Press Cambridge, UK 10.1192/bjb.2022.8 S2056469422000080 Erratum A 10-year follow-up service evaluation of the treatment pathway outcomes for patients in nine in-patient psychiatric rehabilitation services - ERRATUM Edwards Tom Meaden Alan Commander Martin 2 2023 2 2023 47 1 6363 (c) The Author(s) 2022 2022 The Author(s) This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence ), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: Published by Cambridge University Press, 11th January 2022.Keywords Rehabilitation schizophrenia psychotic disorders outcome studies in-patients pmcThe first author's name was incorrectly published in the above article. This has since been corrected. The Publisher apologises for the error. Reference 1 Edwards, T, Meaden A, Commander M. A 10-year follow-up service evaluation of the treatment pathway outcomes for patients in nine in-patient psychiatric rehabilitation services. BJPsych Bull 2022; 1-5. doi: 10.1192/bjb.2021.123. |
BJPsych Bull BJPsych Bull BJB BJPsych Bulletin 2056-4694 2056-4708 Cambridge University Press Cambridge, UK 10.1192/bjb.2022.20 S2056469422000201 Corrigendum Serenity Integrated Mentoring and the High Intensity Network: A scheme that raises serious questions for practice and governance in UK psychiatry - CORRIGENDUM House Allan 2 2023 2 2023 47 1 6262 (c) The Author(s) 2022 2022 The Author(s) This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence ), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: Published online by Cambridge University Press, 11 March 2022.Keywords Suicide crisis services stigma and discrimination service users psychiatry and law pmcThe author would like to correct two errors in the above article1. There was an incorrect word published in the title and abstract: 'Serenity Integrated Monitoring' should be 'Serenity Integrated Mentoring'. This has since been updated in the online PDF and HTML versions. The first heading 'What is Serenity Integrated Monitoring (SIM)' should also read 'What is Serenity Integrated Mentoring (SIM)'. There is a spelling error in a name in the Acknowledgments section. This should read Alex Thomson, not Alex Thompson. The author apologises for these errors. Reference 1 House A. Serenity Integrated Mentoring and the High Intensity Network: a scheme that raises serious questions for practice and governance in UK psychiatry. BJPsych Bulletin, 1-4. 10.1192/bjb.2022.6 |
BJPsych Bull BJPsych Bull BJB BJPsych Bulletin 2056-4694 2056-4708 Cambridge University Press Cambridge, UK 10.1192/bjb.2022.97 S2056469422000973 Corrigendum A 10-year follow-up service evaluation of the treatment pathway outcomes for patients in nine in-patient psychiatric rehabilitation services - CORRIGENDUM Edwards Tom Meaden Alan Commander Martin 2 2023 2 2023 47 1 6464 (c) The Author(s) 2023 2023 The Author(s) This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence ), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: Published online by Cambridge University Press, 11 January 2022Keywords Rehabilitation schizophrenia psychotic disorders outcome studies in-patients corrigendum pmcThis notice is to correct an erroneous reference in the aforementioned paper. In the last paragraph of p. 2 of the paper, there is an erroneous mention of "HRUs". This should be "HDUs" and the paragraph should read as follows: Three CRU patients moved to a CCU, whereas one CCU patient moved to a ward specifically designated for infirmed older patients and another spent a period on a HDU before returning to the same complex care setting. Most movement occurred within HDUs: of the ten patients who changed ward, five moved to low or medium secure facilities, four moved to CCUs and one moved to a CRU (following a period of time on a low secure ward). Reference Edwards T, Meaden A, Commander M. A 10-year follow-up service evaluation of the treatment pathway outcomes for patients in nine in-patient psychiatric rehabilitation services. BJPsych Bull 2022; 47 : xx-xx. |
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bioRxiv BIORXIV bioRxiv Cold Spring Harbor Laboratory 36945652 10.1101/2023.02.03.527066 preprint 3 Article A randomized multiplex CRISPRi-Seq approach for the identification of critical combinations of genes Ellis Nicole A. Myers Kevin S. Tung Jessica Ward Anne Davidson Johnston Kathryn Bonnington Katherine E. Donohue Timothy J. Machner Matthias P. 08 11 2023 2023.02.03.527066 nihpp-2023.02.03.527066.pdf Abstract Identifying virulence-critical genes from pathogens is often limited by functional redundancy. To rapidly interrogate the contributions of combinations of genes to a biological outcome, we have developed a mu ltiplex, randomized C RISPR interference s equencing (MuRCiS) approach. At its center is a new method for the randomized self-assembly of CRISPR arrays from synthetic oligonucleotide pairs. When paired with PacBio long-read sequencing, MuRCiS allowed for near-comprehensive interrogation of all pairwise combinations of a group of 44 Legionella pneumophila virulence genes encoding highly conserved transmembrane proteins for their role in pathogenesis. Both amoeba and human macrophages were challenged with L. pneumophila bearing the pooled CRISPR array libraries, leading to the identification of several new virulence-critical combinations of genes. lpg2888 and lpg3000 were particularly fascinating for their apparent redundant functions during L. pneumophila human macrophage infection, while lpg3000 alone was essential for L. pneumophila virulence in the amoeban host Acanthamoeba castellanii . Thus, MuRCiS provides a method for rapid genetic examination of even large groups of redundant genes, setting the stage for application of this technology to a variety of biological contexts and organisms. pmc |
bioRxiv BIORXIV bioRxiv Cold Spring Harbor Laboratory 36945461 10.1101/2023.03.06.531303 preprint 2 Article Roles of microbiota in autoimmunity in Arabidopsis Cheng Yu Ti Thireault Caitlin A. Paasch Bradley C. Zhang Li He Sheng Yang 04 7 2023 2023.03.06.531303 nihpp-2023.03.06.531303.pdf Abstract Over the past three decades, researchers have isolated plant mutants that display constitutively activated defense responses in the absence of pathogen infection. These mutants are called autoimmune mutants and are typically dwarf and/or bearing chlorotic/necrotic lesions. From a genetic screen for Arabidopsis genes involved in maintaining a normal leaf microbiota, we identified TIP GROWTH DEFECTIVE 1 ( TIP1 ), which encodes a S-acyltransferase, as a key player in guarding leaves against abnormal microbiota level and composition under high humidity conditions. The tip1 mutant has several characteristic phenotypes of classical autoimmune mutants, including a dwarf stature, displaying lesions, and having a high basal level of defense gene expression. Gnotobiotic experiments revealed that the autoimmune phenotypes of the tip1 mutant are largely dependent on the presence of microbiota as axenic tip1 plants have markedly reduced autoimmune phenotypes. We found that the microbiota dependency of autoimmune phenotypes is shared by several "lesion mimic"-type autoimmune mutants in Arabidopsis . Interestingly, autoimmune phenotypes caused by mutations in NLR genes do not require the presence of microbiota and can even be partially alleviated by microbiota. Our results therefore suggest the existence of two classes of autoimmunity (microbiota-dependent vs. microbiota-independent) in plants. The observed interplay between autoimmunity and microbiota in the lesion mimic class of autoimmunity is reminiscent of the interactions between autoimmunity and dysbiosis in the animal kingdom. pmc |
bioRxiv BIORXIV bioRxiv Cold Spring Harbor Laboratory 36945441 10.1101/2023.03.03.531029 preprint 3 Article GoM DE: interpreting structure in sequence count data with differential expression analysis allowing for grades of membership Carbonetto Peter Luo Kaixuan Sarkar Abhishek Hung Anthony Tayeb Karl Pott Sebastian Stephens Matthew 14 9 2023 2023.03.03.531029 nihpp-2023.03.03.531029.pdf Parts-based representations, such as non-negative matrix factorization and topic modeling, have been used to identify structure from single-cell sequencing data sets, in particular structure that is not as well captured by clustering or other dimensionality reduction methods. However, interpreting the individual parts remains a challenge. To address this challenge, we extend methods for differential expression analysis by allowing cells to have partial membership to multiple groups. We call this grade of membership differential expression (GoM DE). We illustrate the benefits of GoM DE for annotating topics identified in several single-cell RNA-seq and ATAC-seq data sets. pmc |
bioRxiv BIORXIV bioRxiv Cold Spring Harbor Laboratory 10.1101/2023.03.07.531400 preprint 1 Article Single Nucleus Transcriptomics Reveals Pervasive Glial Activation in Opioid Overdose Cases Wei Julong Lambert Tova Y. Valada Aditi Patel Nikhil Walker Kellie Lenders Jayna Schmidt Carl J. Iskhakova Marina Alazizi Adnan Mair-Meijers Henriette Mash Deborah C. Luca Francesca Pique-Regi Roger Bannon Michael J Akbarian Schahram 09 3 2023 2023.03.07.531400 nihpp-2023.03.07.531400.pdf ABSTRACT Dynamic interactions of neurons and glia in the ventral midbrain (VM) mediate reward and addiction behavior. We studied gene expression in 212,713 VM single nuclei from 95 human opioid overdose cases and drug-free controls. Chronic exposure to opioids left numerical proportions of VM glial and neuronal subtypes unaltered, while broadly affecting glial transcriptomes, involving 9.5 - 6.2% of expressed genes within microglia, oligodendrocytes, and astrocytes, with prominent activation of the immune response including interferon, NFkB signaling, and cell motility pathways, sharply contrasting with down-regulated expression of synaptic signaling and plasticity genes in VM non-dopaminergic neurons. VM transcriptomic reprogramming in the context of opioid exposure and overdose included 325 genes with genetic variation linked to substance use traits in the broader population, thereby pointing to heritable risk architectures in the genomic organization of the brainaEURTMs reward circuitry. pmc |
bioRxiv BIORXIV bioRxiv Cold Spring Harbor Laboratory 36945557 10.1101/2023.03.07.530278 preprint 2 Article Identifying and overcoming the sampling challenges in relative binding free energy calculations of a model protein:protein complex Zhang Ivy Rufa Dominic A. Pulido Ivan Henry Michael M. Rosen Laura E. Hauser Kevin Singh Sukrit Chodera John D. 21 6 2023 2023.03.07.530278 nihpp-2023.03.07.530278.pdf Abstract Relative alchemical binding free energy calculations are routinely used in drug discovery projects to optimize the affinity of small molecules for their drug targets. Alchemical methods can also be used to estimate the impact of amino acid mutations on protein:protein binding affinities, but these calculations can involve sampling challenges due to the complex networks of protein and water interactions frequently present in protein:protein interfaces. We investigate these challenges by extending a GPU-accelerated open-source relative free energy calculation package (Perses) to predict the impact of amino acid mutations on protein:protein binding. Using the well-characterized model system barnase:barstar, we describe analyses for identifying and characterizing sampling problems in protein:protein relative free energy calculations. We find that mutations with sampling problems often involve charge-changes, and inadequate sampling can be attributed to slow degrees of freedom that are mutation-specific. We also explore the accuracy and efficiency of current state-of-the-art approaches alchemical replica exchange and alchemical replica exchange with solute tempering for overcoming relevant sampling problems. By employing sufficiently long simulations, we achieve accurate predictions (RMSE 1.61, 95% CI: [1.12, 2.11] kcal/mol), with 86% of estimates within 1 kcal/mol of the experimentally-determined relative binding free energies and 100% of predictions correctly classifying the sign of the changes in binding free energies. Ultimately, we provide a model workflow for applying protein mutation free energy calculations to protein:protein complexes, and importantly, catalog the sampling challenges associated with these types of alchemical transformations. Our free open-source package (Perses) is based on OpenMM and available at . pmc |
bioRxiv BIORXIV bioRxiv Cold Spring Harbor Laboratory 10.1101/2023.03.07.529561 preprint 1 Article The Vibrio fischeri type VI secretion system incurs a fitness cost under host-like conditions Septer Alecia N. Sharpe Garrett Shook Erika A. 07 3 2023 2023.03.07.529561 nihpp-2023.03.07.529561.pdf Abstract The type VI secretion system (T6SS) is an interbacterial weapon composed of thousands of protein subunits and predicted to require significant cellular energy to deploy, yet a fitness cost from T6SS use is rarely observed. Here, we identify host-like conditions where the T6SS incurs a fitness cost using the beneficial symbiont, Vibrio fischeri , which uses its T6SS to eliminate competitors in the natural squid host. We hypothesized that a fitness cost for the T6SS could be dependent on the cellular energetic state and used theoretical ATP cost estimates to predict when a T6SS-dependent fitness cost may be apparent. Theoretical energetic cost estimates predicted a minor relative cost for T6SS use in fast-growing populations (0.4-0.45% of total ATP used cell -1 ), and a higher relative cost (3.1-13.6%) for stationary phase cells. Consistent with these predictions, we observed no significant T6SS-dependent fitness cost for fast-growing populations typically used for competition assays. However, the stationary phase cell density was significantly lower in the wild-type strain, compared to a regulator mutant that does not express the T6SS, and this T6SS-dependent fitness cost was between 11 and 23%. Such a fitness cost could influence the prevalence and biogeography of T6SSs in animal-associated bacteria. While the T6SS may be required in kill or be killed scenarios, once the competitor is eliminated there is no longer selective pressure to maintain the weapon. Our findings indicate an evolved genotype lacking the T6SS would have a growth advantage over its parent, resulting in the eventual dominance of the unarmed population. pmc |
bioRxiv BIORXIV bioRxiv Cold Spring Harbor Laboratory 10.1101/2023.03.08.531744 preprint 1 Article Sensitive cluster-free differential expression testing. Missarova Alsu Rosen Leah Ursula Dann Emma Satija Rahul Marioni John 10 3 2023 2023.03.08.531744 nihpp-2023.03.08.531744.pdf Comparing molecular features, including the identification of genes with differential expression (DE) between conditions, is a powerful approach for characterising disease-specific phenotypes. When testing for DE in single-cell RNA sequencing data, current pipelines first assign cells into discrete clusters (or cell types), followed by testing for differences within each cluster. Consequently, the sensitivity and specificity of DE testing are limited and ultimately dictated by the granularity of the cell type annotation, with discrete clustering being especially suboptimal for continuous trajectories. To overcome these limitations, we present miloDE - a cluster-free framework for differential expression testing. We build on the Milo approach, introduced for differential cell abundance testing, which leverages the graph representation of single-cell data to assign relatively homogenous, neighbouring cells into overlapping neighbourhoods. We address key differences between differential abundance and expression testing at the level of neighbourhood assignment, statistical testing, and multiple testing correction. To illustrate the performance of miloDE we use both simulations and real data, in the latter case identifying a transient haemogenic endothelia-like state in chimeric mouse embryos lacking Tal1 as well as uncovering distinct transcriptional programs that characterise changes in macrophages in patients with Idiopathic Pulmonary Fibrosis. miloDE is available as an open-source R package at pmc |
bioRxiv BIORXIV bioRxiv Cold Spring Harbor Laboratory 10.1101/2023.03.07.531414 preprint 1 Article Empowering Beginners in Bioinformatics with ChatGPT Shue Evelyn Liu Li Li Bingxin Feng Zifeng Li Xin Hu Gangqing 08 3 2023 2023.03.07.531414 nihpp-2023.03.07.531414.pdf Abstract The impressive conversational and programming abilities of ChatGPT make it an attractive tool for facilitating the education of bioinformatics data analysis for beginners. In this study, we proposed an iterative model to fine-tune instructions for guiding a ChatGPT in generating code for bioinformatics data analysis tasks. We demonstrated the feasibility of the model by applying it to various bioinformatics topics. Additionally, we discussed practical considerations and limitations regarding the use of the model in chatbot-aided bioinformatics education. pmc |
bioRxiv BIORXIV bioRxiv Cold Spring Harbor Laboratory 36945619 10.1101/2023.03.10.532020 preprint 2 Article Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle Diaz-Vegas Alexis Madsen Soren Cooke Kristen C. Carroll Luke Khor Jasmine X. Y. Turner Nigel Lim Xin Ying Astore Miro A. Morris Jonathan Don Anthony Garfield Amanda Zarini Simona Zemski Berry Karin A. Ryan Andrew Bergman Bryan C. Brozinick Joseph T. James David E. Burchfield James G. 19 9 2023 2023.03.10.532020 nihpp-2023.03.10.532020.pdf Summary Insulin resistance (IR) is a complex metabolic disorder that underlies several human diseases, including type 2 diabetes and cardiovascular disease. Despite extensive research, the precise mechanisms underlying IR development remain poorly understood. Here, we provide new insights into the mechanistic connections between cellular alterations associated with IR, including increased ceramides, deficiency of coenzyme Q (CoQ), mitochondrial dysfunction, and oxidative stress. We demonstrate that elevated levels of ceramide in the mitochondria of skeletal muscle cells results in CoQ depletion and loss of mitochondrial respiratory chain components, leading to mitochondrial dysfunction and IR. Further, decreasing mitochondrial ceramide levels in vitro and in animal models (under chow and high fat diet) increased CoQ levels and was protective against IR. CoQ supplementation also rescued ceramide-associated IR. Examination of the mitochondrial proteome from human muscle biopsies revealed a strong correlation between the respirasome system and mitochondrial ceramide as key determinants of insulin sensitivity. Our findings highlight the mitochondrial Ceramide-CoQ-respiratory chain nexus as a potential foundation of an IR pathway that may also play a critical role in other conditions associated with ceramide accumulation and mitochondrial dysfunction, such as heart failure, cancer, and aging. These insights may have important clinical implications for the development of novel therapeutic strategies for the treatment of IR and related metabolic disorders. pmc |
bioRxiv BIORXIV bioRxiv Cold Spring Harbor Laboratory 36945406 10.1101/2023.03.11.532186 preprint 2 Article Pharmacologic Activation of a Compensatory Integrated Stress Response Kinase Promotes Mitochondrial Remodeling in PERK-deficient Cells Perea Valerie Baron Kelsey R. Dolina Vivian Aviles Giovanni Rosarda Jessica D. Guo Xiaoyan Kampmann Martin Wiseman R. Luke 17 5 2023 2023.03.11.532186 nihpp-2023.03.11.532186.pdf SUMMARY The integrated stress response (ISR) comprises the eIF2a kinases PERK, GCN2, HRI, and PKR, which induce translational and transcriptional signaling in response to diverse insults. Deficiencies in PERK signaling lead to mitochondrial dysfunction and contribute to the pathogenesis of numerous diseases. We define the potential for pharmacologic activation of compensatory eIF2a kinases to rescue ISR signaling and promote mitochondrial adaptation in PERK-deficient cells. We show that the HRI activator BtdCPU and GCN2 activator halofuginone promote ISR signaling and rescue ER stress sensitivity in PERK-deficient cells. However, BtdCPU induces mitochondrial depolarization, leading to mitochondrial fragmentation and activation of the OMA1-DELE1-HRI signaling axis. In contrast, halofuginone promotes mitochondrial elongation and adaptive mitochondrial respiration, mimicking regulation induced by PERK. This shows halofuginone can compensate for deficiencies in PERK signaling and promote adaptive mitochondrial remodeling, highlighting the potential for pharmacologic ISR activation to mitigate mitochondrial dysfunction and motivating the pursuit of highly-selective ISR activators. pmc |
medRxiv MEDRXIV medRxiv Cold Spring Harbor Laboratory 10.1101/2023.03.06.23286886 preprint 1 Article Archetypal analysis of COVID-19 in Montana, USA, March 13, 2020 to April 26, 2022 Stone Emily Coombs Sebastian Landguth Erin 09 3 2023 2023.03.06.23286886 nihpp-2023.03.06.23286886.pdf Abstract Given the potential consequences of infectious diseases, it is important to understand how broad scale incidence variability influences the probability of localized outbreaks. Often, these infectious disease data can involve complex spatial patterns intermixed with temporal trends. Archetypal Analysis is a method to mine complex spatiotemporal epidemiological data, and can be used to discover the dynamics of spatial patterns. The application of Archetypal Analysis to epistemological data is relatively new, and here we present one of the first applications using COVID-19 data from March 13, 2020 to April 26, 2022, in the counties of Montana, USA. We present three views of the data set with Archetypal Analysis. First, we evaluate the entire 56 county data set. Second, we compute mutual information of the 56 countiesaEURTM time series to remove counties whose dynamics are mainly independent from most of the other counties. We choose the top 17 counties ranked in terms of increasing total mutual information. Finally, to compare how population size might influence results, we conducted an analysis with 10 of the largest counties. Using the Archetypal Analysis results, we analyze the disease outbreaks across Montana, comparing and contrasting the three different cases and showing how certain counties can be found in distinct sets of archetypes. Using the reconstruction time series, we show how each outbreak had a unique trajectory across the state in terms of the archetypes. Author summary Archetypal Analysis provides an additional tool for the study of spatio-temporal epidemiological data. We apply Archetypal Analysis to COVID-19 data and reveal how this approach can be used to analyse the dynamics of each COVID-19 outbreak across the state. pmc |
Res Sq ResearchSquare Research Square American Journal Experts 10.21203/rs.3.rs-2580940/v1 10.21203/rs.3.rs-2580940 preprint 1 Article A comparative investigation of variant calling and genotyping for a single non-Caucasian whole genome Park HyeonSeul Gim JungSoo 06 3 2023 rs.3.rs-2580940 This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. nihpp-rs2580940v1.pdf Abstract Most genome benchmark studies utilize hg38 as a reference genome (based on Caucasian and African samples) and 'NA12878' (a Caucasian sequencing read) for comparison. Here, we aimed to elucidate whether 1) ethnic match or mismatch between the reference genome and sequencing reads produces a distinct result; 2) there is an optimal workflow for single genome data. We assessed the performance of variant calling pipelines using hg38 and a Korean genome (reference genomes) and two whole-genome sequencing (WGS) reads from different ethnic origins: Caucasian (NA12878) and Korean. The pipelines used BWA-mem and Novoalign as mapping tools and GATK4, Strelka2, DeepVariant, and Samtools as variant callers. Using hg38 led to better performance (based on precision and recall), regardless of the ethnic origin of the WGS reads. Novoalign + GATK4 demonstrated best performance when using both WGS data. We assessed pipeline efficiency by removing the markduplicate process, and all pipelines, except Novoalign + DeepVariant, maintained their performance. Novoalign identified more variants overall and in MHC of chr6 when combined with GATK4. No evidence suggested improved variant calling performance from single WGS reads with a different ethnic reference, re-validating hg38 utility. We recommend using Novoalign + GATK4 without markduplication for single PCR-free WGS data. pmc |
medRxiv MEDRXIV medRxiv Cold Spring Harbor Laboratory 10.1101/2023.03.08.23286582 preprint 1 Article Assessing the utility of COVID-19 case reports as a leading indicator for hospitalization forecasting in the United States Reich Nicholas G Wang Yijin Burns Meagan Ergas Rosa Cramer Estee Y Ray Evan L 10 3 2023 2023.03.08.23286582 nihpp-2023.03.08.23286582.pdf Abstract Identifying data streams that can consistently improve the accuracy of epidemiological forecasting models is challenging. Using models designed to predict daily state-level hospital admissions due to COVID-19 in California and Massachusetts, we investigated whether incorporating COVID-19 case data systematically improved forecast accuracy. Additionally, we considered whether using case data aggregated by date of test or by date of report from a surveillance system made a difference to the forecast accuracy. Evaluating forecast accuracy in a test period, after first having selected the best-performing methods in a validation period, we found that overall the difference in accuracy between approaches was small, especially at forecast horizons of less than two weeks. However, forecasts from models using cases aggregated by test date showed lower accuracy at longer horizons and at key moments in the pandemic, such as the peak of the Omicron wave in January 2022. Overall, these results highlight the challenge of finding a modeling approach that can generate accurate forecasts of outbreak trends both during periods of relative stability and during periods that show rapid growth or decay of transmission rates. While COVID-19 case counts seem to be a natural choice to help predict COVID-19 hospitalizations, in practice any benefits we observed were small and inconsistent. pmc |
medRxiv MEDRXIV medRxiv Cold Spring Harbor Laboratory 10.1101/2023.03.08.23286983 preprint 1 Article Prospective Bidirectional Relations Between Depression and Metabolic Health: 30 Year Follow-up from the NHLBI CARDIA Study Moorehead Nicholas R. Goodie Jeffrey L. Krantz David S. 10 3 2023 2023.03.08.23286983 nihpp-2023.03.08.23286983.pdf ABSTRACT Objective This study investigated prospective bidirectional relationships between depression and metabolic syndrome (MetS), and the moderating effects of race, sex, and health behaviors in a diverse cohort followed for 30 years. Methods Data were analyzed from the NHLBI CARDIA study, a 30 year-prospective study of young adults ( N = 5113; M age = 24.76 ( SD = 3.63) at baseline; 45% male) who were tested every 5 years between 1985-2015. Measures included biological assessments of MetS components, and self-reported depressive symptoms based on the Center for Epidemiologic Studies Depression (CESD) scale. Data analyses included bi-directional general estimating equations analyses of time-lagged associations between depressive symptoms and MetS. Results There was a consistent, bi-directional relationship between depressive symptoms and MetS over time. Individuals with more CESD depressive symptoms were more likely to develop MetS over time compared to those reporting fewer symptoms (Wald Chi-Square = 7.09 (1), p < 0.008), and MetS was similarly predictive of CESD. MetS more consistently predicted depressive symptoms at each 5-year exam than depressive symptoms predicted MetS. Race and sex moderated relationships between depression and MetS, with White females, White individuals overall, and females overall demonstrating significant relationships. Health behaviors were not related to depression-MetS associations. Conclusion In a diverse young adult population prospectively followed into late middle age, MetS more consistently predicted depression over time than depression predicted MetS. The relation between MetS and depressive symptoms was moderated by race and sex, but not health behaviors. pmc |
medRxiv MEDRXIV medRxiv Cold Spring Harbor Laboratory 10.1101/2023.03.09.23287048 preprint 1 Article Cause of Death by Race and Ethnicity in Minnesota Before and During the COVID-19 Pandemic, 2019-2020 Blake Madelyn J. Marka Nicholas A. Steer Clifford J. Ravdin Jonathan I. 10 3 2023 2023.03.09.23287048 nihpp-2023.03.09.23287048.pdf ABSTRACT Objectives To measure changes in cause of death dynamics in 2019 and 2020 and the relationship between concurrent occurrence of the COVID-19 pandemic and mortality outcome by race and ethnicity. Patients and Methods We used resident mortality data from the Minnesota Department of Health (MDH) to conduct retrospective statistical analysis of deaths in Minnesota in 2019 relative to 2020 to assess changes in mortality in a pre-pandemic and pandemic period. Results COVID-19 strongly contributed to ethnicity-related mortality disparities in Minnesota. Not only was there a greater proportion of COVID-19 decedents within the Black and Hispanic populations, but their average decedent age was markedly lower relative to the White population. The Black population experienced a disproportionate increase in decedents with a 34% increase during 2020 compared to 2019. Conclusions This retrospective analysis of death dynamics and mortality outcomes in Minnesota from 2019 to 2020 demonstrated an increase in adverse mortality outcomes relative to the pre-pandemic period that disproportionately impacted Black and Hispanic minority populations. Access to non-pharmaceutical interventions combating COVID-19 infection in Black and Hispanic communities should be expanded in Minnesota. pmc |
Front Microbiol Front Microbiol Front. Microbiol. Frontiers in Microbiology 1664-302X Frontiers Media S.A. 10.3389/fmicb.2023.1170284 Microbiology Erratum Erratum: Soil Acidobacterial community composition changes sensitively with wetland degradation in northeastern of China Frontiers Production Office * Frontiers Media SA, Lausanne, Switzerland Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland *Correspondence: Frontiers Production Office [email protected] This article was submitted to Microbe and Virus Interactions with Plants, a section of the journal Frontiers in Microbiology 07 3 2023 2023 07 3 2023 14 117028420 2 2023 20 2 2023 Copyright (c) 2023 Frontiers Production Office. 2023 Frontiers Production Office This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. An Erratum on Soil Acidobacterial community composition changes sensitively with wetland degradation in northeastern of China by Sui, X., Frey, B., Yang, L., Liu, Y., Zhang, R., Ni, H., and Li, M.-H. (2022). Front. Microbiol. 13:1052161. doi: 10.3389/fmicb.2022.1052161 Sanjiang plain soil bacterial diversity b diversity high-throughput sequencing forest community structure pmcAn omission to the funding section of the original article was made in error. The following sentence has been added: "Open access funding was provided by the WSL Swiss Federal Institute for Forest, Snow and Landscape Research." The original article has been updated. |
Res Sq ResearchSquare Research Square American Journal Experts 10.21203/rs.3.rs-2566520/v1 10.21203/rs.3.rs-2566520 preprint 1 Article Inflammatory memory restrains intestinal stem cell regeneration Reddy Pavan Zhao Dongchang Ravikumar Visweswaran Lauder Emma Li Lu Sun Yaping Oravecz-Wilson Katherine Brooks Michael Keller Evan Chen Fengju Maneix Laure Santibanez Ana Creighton Chad Rao Arvind 07 3 2023 rs.3.rs-2566520 This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. nihpp-rs2566520v1.pdf Abstract Intestinal stem cells (ISC) encounter inflammatory insults in immune mediated gastro-intestinal (GI) diseases. It remains unknown whether, and how, they adapt, and if the adaptation leaves scars on the ISCs that affects their subsequent regeneration capacity. We investigated the consequences of inflammation on Lgr5 + ISCs in well-defined clinically relevant models of gastro-intestinal acute graft-versus-host disease (GI GVHD). Utilizing single cell transcriptomics, organoid, metabolic, epigenomic and in vivo models we found that Lgr5 + ISCs undergo metabolic changes that lead to accumulation of succinate, which reprograms its epigenome. These changes reduced the ability of ISCs to differentiate and regenerate ex vivo in serial organoid cultures demonstrating the persistence of the maladaptive impact of an in vivo inflammatory encounter by the ISCs. Thus, inflammation from GI GVHD leaves a memory of its effects on ISCs that persist and are likely to affect their sensitivity to adapt to future stress or challenges. pmc |
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Front Med (Lausanne) Front Med (Lausanne) Front. Med. Frontiers in Medicine 2296-858X Frontiers Media S.A. 10.3389/fmed.2023.1172589 Medicine Erratum Erratum: Unsupervised clustering reveals phenotypes of AKI in ICU COVID-19 patients Frontiers Production Office * Frontiers Media SA, Lausanne, Switzerland Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland *Correspondence: Frontiers Production Office [email protected] This article was submitted to Nephrology, a section of the journal Frontiers in Medicine 07 3 2023 2023 07 3 2023 10 117258923 2 2023 23 2 2023 Copyright (c) 2023 Frontiers Production Office. 2023 Frontiers Production Office This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. An Erratum on Unsupervised clustering reveals phenotypes of AKI in ICU COVID-19 patients by Legouis, D., Criton, G., Assouline, B., Le Terrier, C., Sgardello, S., Pugin, J., Marchi, E., and Sangla, F. (2022). Front. Med. 9:980160. doi: 10.3389/fmed.2022.980160 AKI clustering machine learning COVID-19 critical care pmcAn omission to the funding section of the original article was made in error. The following sentence has been added: "Open access funding was provided by the University of Geneva." The original article has been updated. |
and articles screening, reviewing, extraction: RG, DB, KT, CD, NL. Data analysis and interpretation: RG, NL, JW, RP. Drafting the article: RG. Critical revision and approval of manuscript: all authors. All authors read and approved the final manuscript. Funding This project was funded by an MD-PhD scholarship from the Swiss National Science Foundation (grant number 191225), a Swiss National Science Foundation project (number 197831), and a Swiss government excellence scholarship (grant number 2019.0774), and the SSPH + Global PhD Fellowship Programme in Public Health Sciences of the Swiss School of Public Health. Availability of data and materials All data generated or analysed during this study are included in this published article, its supplementary information files or can be obtained via request to the corresponding author. Declarations Ethics approval and consent to participate Not applicable because only already published articles were reviewed. Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
Book Notices. On Some Diseases of the Nervous System in Childhood: being the Lumlian Lectures Delivered at the Royal College of Physicians of London, in March, 1871. By Charles West, M.D., Fellow and Senior Censor of the College; Physician to the Hospital for Sick Children. Philadelphia: Henry C. Lea. 1871. This is a neatly published duodecimo volume of 131 pages. It is made up of three lectures, the first, on Neuralgia and ; the second, on Chorea and Paralysis; and the third, on Disorder and Loss of Power of Speech, Mental and Moral Peculiarities and their Disorders. The author is one of the most experienced and able writers on the diseases of women and children that we have in the profession; and the present little volume will be found worthy of perusal by every . |
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