Dataset Viewer
Entry
stringlengths 6
10
| EC_number
stringclasses 260
values | Active_site
stringlengths 0
544
| Sequence
stringlengths 20
2.05k
| labels
int16 1
260
|
|---|---|---|---|---|
A0A9R0IT30
|
1.11.1.7
|
ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
NQLGAQTNVIAFLFLFFSSPLTLALQVGFYSKTCPNAETIVQQVVQQRFAADKSVAAALLRMHFHDCFVRGCDASILIDSTSTNQAEKASGANGSVREFALIDQIKAKLEQSCPQTVSCADIITLATRDSVALVGGPKYNVPTGRRDGLISKSNEVNVPGPSSTVSQAQQSFKIKGLTINDMVVLLGGHTVGITHCSFISDRLTNFQGTGAPDPTMNKTLLTQLKGTCGANPSADPSIFLDQKTPFVFDNEYYNQLKSNNGVLQIDQELAVDPLSSTLVNNMAANNAGFVQNFAKAMVKMGGIQVLQGTAGEIRTNCRVFNKN
| 14 |
O64784
|
2.7.11.1
|
ACT_SITE 623; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
|
MRIVACLLLITALFSSYGYAAITTSSPLSIGVTLSSPGGSYELGFFSSNNSGNQYVGIWFKKVTPRVIVWVANREKPVSSTMANLTISSNGSLILLDSKKDLVWSSGGDPTSNKCRAELLDTGNLVVVDNVTGNYLWQSFEHLGDTMLPLTSLMYDIPNNKKRVLTSWKSETDPSPGEFVAEITPQVPSQGLIRKGSSPYWRSGPWAGTRFTGIPEMDASYVNPLGMVQDEVNGTGVFAFCVLRNFNLSYIKLTPEGSLRITRNNGTDWIKHFEGPLTSCDLYGRCGPFGLCVRSGTPMCQCLKGFEPKSDEEWRSGNWSRGCVRRTNLSCQGNSSVETQGKDRDVFYHVSNIKPPDSYELASFSNEEQCHQGCLRNCSCTAFSYVSGIGCLVWNQELLDTVKFIGGGETLSLRLAHSELTGRKRIKIITVATLSLSVCLILVLVACGCWRYRVKQNGSSLVSKDNVEGAWKSDLQSQDVSGLNFFEIHDLQTATNNFSVLNKLGQGGFGTVYKGKLQDGKEIAVKRLTSSSVQGTEEFMNEIKLISKLQHRNLLRLLGCCIDGEEKLLVYEYMVNKSLDIFIFDLKKKLEIDWATRFNIIQGIARGLLYLHRDSFLRVVHRDLKVSNILLDEKMNPKISDFGLARLFHGNQHQDSTGSVVGTLGYMSPEYAWTGTFSEKSDIYSFGVLMLEIITGKEISSFSYGKDNKNLLSYAWDSWSENGGVNLLDQDLDDSDSVNSVEAGRCVHIGLLCVQHQAIDRPNIKQVMSMLTSTTDLPKPTQPMFVLETSDEDSSLSHSQRSNDLSSVDENKSSEELNASS
| 99 |
W1PC58
|
3.1.1.11
|
ACT_SITE 62; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MGGFQNAAPKPAAGAQSQAVAMRISGDKAAFYNCRFYGYQDTLLDDKGRHFFKDCYIEGSVDFIFGSGRSLYRNCEIRSVSDYPGQTAIVAQGKSSKGDKSGFVFLDCHVTGMGDVYLSRAWREYSRVVFAYSYFDTVVNPEGWNDKGFTERDKTVFYGEYKCEGPGANTNRRVDYVKLLTDAQAKPFLDESFIRGRTWILPPPTL
| 125 |
P21182
|
4.1.1.50
|
ACT_SITE 29; /evidence="ECO:0000250"; ACT_SITE 32; /evidence="ECO:0000250"; ACT_SITE 88; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000269|PubMed:2266128"; ACT_SITE 102; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000250"; ACT_SITE 287; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000250"; ACT_SITE 301; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000250"
|
MTVTIKELTNHNYIDHELSATLDSTDAFEGPEKLLEIWFFPHKKSITTEKTLRNIGMDRWIEILKLVKCEVLSMKKTKELDAFLLSESSLFVFDHKLTMKTCGTTTTLFCLEKLFQIVEQELSWAFRTTQGGKYKPFKVFYSRRCFLFPCKQAAIHQNWADEVDYLNKFFDNGKSYSVGRNDKSNHWNLYVTETDRSTPKGKEYIEDDDETFEVLMTELDPECASKFVCGPEASTTALVEPNEDKGHNLGYQMTKNTRLDEIYVNSAQDSDLSFHHDAFAFTPCGYSSNMILAEKYYYTLHVTPEKGWSYASFESNIPVFDISQGKQDNLDVLLHILNVFQPREFSMTFFTKNYQNQSFQKLLSINESLPDYIKLDKIVYDLDDYHLFYMKLQKKI
| 196 |
P94462
|
3.5.1.88
|
ACT_SITE 133; /evidence="ECO:0000250"
|
MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDGVGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTRADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG
| 183 |
A0A9R0HRH8
|
1.11.1.7
|
ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MTVQKVVSVFVILGTLFAMANAQGLKLNFYKSSCPKAEEIIKRVTEQYVSHVPNFAAGLIRMNFHDCAVRGCDASVLVEPTASNNQTEKTGVPNTTLRGFEVINAIKSAVEKECPGVVSCADILALASRDAIVTIDGPWWEVQTGRRDGKVSLASEANALIPSPFSDVNTLKQNFAALGLSAKDLVVLSGAHTIGIGHCFVIRNRLYNFTRVGDTDPTLSPRYAQHLKSRCPPTPTDVTSFVAMDHITPKVFDEKYYTMITQNRGLFTSDATLLDDNETRNYVLTQVQTMGSTFAKDFAVSMTKMINIGVLTGTQGEIRNTCGAVNS
| 14 |
F6H6V9
|
3.1.1.11
|
ACT_SITE 421; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MGYNNAADADSRGKKKVALMGFSSILLVAMVVGTVVTVNHRNGSSSSATDDAQAGGGISTSVKAIQAICQPTDYKEACVNSLTSAKANTSDPKELVRTAFQVAINQISSALQNSTTLRDLEKDPRTKGALENCHELMDYAIDDLRNSFNKLGVFDISKIDDYVEDLKIWLSGALTYQETCLDGFENTTGDAGEKMKALLKSAGELTSNGLAMIDEISSVLTNLQIPGISRRLLSDESGKGEYRSDEGGLYPSWASVGQRKLFQATPDTIKPNVIVAQDGSGKYKTINEALVEIPKNGNTTFVLYVKEGVYKEQVNFTKSMTNVMLIGDGPTKTTISGSLNFIDGIGTFRTATVAAVGSNFMAKDIGFENNAGASKHQAVALRVGSDMAIFYNCRMDGYQDTLYVHAHRQFYRDCTITGTIDFIFGDSAVVFQNCLILVRKPLDNQQCIVTAQGRNERREPTGIVLQNCTISAADDYIPFKTKFKSYLGRPWKAFSRTIIMQSQIDDLISPEGWLPWMGDFGLNTCFYAEYGNRGPASATTSRVTWRGIKQITGQHVNDFTVGRFISGHLWLGASGVPYTSDMMAV
| 125 |
A0A072UAE2
|
1.11.1.7
|
ACT_SITE 82; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MAKNSASITSFYSFLLISSILFASYFHASKAQTNAPPAVKGLSYGFFAQTCPNLENIVRKHLTKVFKSDNGQAPGLLRIFFHDCFVQGCDGSVLLDGKPGERDQPQNGGMRTEALKTIDDIRALVHKECGRIVSCADITVLAGREAVFLSGGPNFPVPLGRKDGTSFSIKGTSNLPQPFNKTDVTLKVFAAQNFDVTDVVALSGAHTFGRAHCGTFFNRLSPADPTLDKTLAQNLKNTCPNANSGNTANLDIRTPATFDNKYYLDLMNKQGLFTSDQDLNIDSRTKGLVNDFAVNQGLFFEKFVNAFIKVSQLNVLVGNQGEIRGKCNVVNGGKKSVLSTLVEEGMDLIEQF
| 14 |
Q8Y8D7
|
2.7.1.23
|
ACT_SITE 45; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:17686780"
|
MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGIGKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIED
| 89 |
A0A2R6XN30
|
1.11.1.7
|
ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MAGARVKAFAILCMVALCLHMADAQVRGLRVNYYQRSCPRAEQIIRTAVQNGFNSDPTIPAGLIRMLFHDCFVRGCDASVLLDNADSEKLGAPNANSLRGFEVLDAAKSALEAACPGVVSCADVIAYAARDAMEVAGTVKVPNWLGGRKDGSTSVSAETLTELPAPFSNFTTLQRAFERKGLNQADLVILSGAHTIGIARCGIILQRIYNFKGTGQADPAINPAYVQTLRNLCPSNAPGKQINMEMLTPTKIDANYFNDVQAGRGLFESDNALRTTPIGRSLVSVYRVPQVFNAAFVASMRKMASIGVLTGSNGKIRTKCNIA
| 14 |
P53974
|
2.7.11.1
|
ACT_SITE 159; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
|
MNQPQIGTYNVGTQLTVGSHQVEIIKYLTSGGFAQVYSALINPPDPHSNSSVACLKRVIVPDKPSLNTLRAEVDAMRLLKNNRYVVSYIDSHAAKAMLHNGSYEVFVLMEYCERGGLIDFMNTRLQNRLHEFEILQIMSQVTQGVAAMHALQPPLIHRDIKIENVLISANNEYKLCDFGSVCGIIRPPRNSQELSYVQQDILKNTTAQYRSPEMIDTFRGLPIDEKSDIWALGIFLYKLCYYTTPFEKGGDLAILSGKFEFPLYPNYSEQLKGLIRDILVQDPRHRPNVYQLLKRISIMQNVPCPINDIQVVQAPSSHLNLTELHQLSATQNILSLNSPTTMENTMPNATFQISMADNTTTAQMHPNRKPSQIAYDASFSNSAKGSQPLFDKSQNMYHALDPPLVEPLASSVSNNDNELKANSATKLKQAIVSEAHTFRQNNSIDFPLQNIIPQYEDSSSSSDESYSGDVDELKKTRSLGSYSTRGNIKKNQSVKESLTSSSLPGTSFTPTSTKVNLKHENSPFKSTFVNTIDNSKDDLNKPSYEDLDVSKQNLKNSIQQRMIDKLNSSEESFNARKMSKVKLHEKGEIDKPTMLKSSGPISKDKKTKPTPPPKPSHLKPKPPPKPLLLAGRKLSLDK
| 99 |
A7RSL3
|
3.1.3.1
|
ACT_SITE 114; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
|
MIRVDTLLVFAFCLVVLTALCSGDVPASQSNNQWFKDGVSTVKKHLLQRPNTKPAKNLIIFVGDGCDINTNTAGRILKGQLKGQVGEKGWLSYEEFPYTGLSKTYTTNRQGSDSAGTANAMFTGVKTRSAMIGVNEEVVTNKCETLTEDRKVDSILKLAEEAGMATGFITSMRLTHATPANLYAHSASRYWESDKEMVSRGYGNTSCKDMAQQLVDFQGSVGDGIEVVMGGGRRSFLPNTTRDPEHVNKTGERYDGRNLIQEWLNKREGSVYAWNKTQFDAVDPKTTKHFLGMFESSHMQFAIDRDEDVGGEPSIAEMVEKAVSILKNNDNGKGFFLAVEAGLIDIGHHNGIARQALNEVVNLEEGVAKAVEMTDKEDTLIISTADHGHVFTLTGYPDINSPIFGLMKQDGEVKLALNDNKPYTILGYMNGPGAVKGVRANLTGVDTGAKDFKQQALYIGYDYDEAHGSQDVGIYSRGPWAHLLTGVVEQNVIFHVMDHALCLSSSKQGTCSKPEARGGPSASAAMVTALFAPLVAALVTCLVLY
| 141 |
Q89WR7
|
3.4.21.92
|
ACT_SITE 102; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 127; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"
|
MRDMLQLVPMVVEQSARGERSFDIYSRLLRERIIFLNGEVNDAMSGLVCAQLLFLEAENPNRPINLYINSYGGVVTSGLAMYDTMQFIKAPVHTLCMGTARSMGSFLLMAGERGHRAALPNASLHVHQPLGGFQGQASDILIHANEMQETKRRITRLYAQHCGRTEAEVERTLDRDHFMTAQQGVEWGLIDRVFAERDAT
| 179 |
A0A0A0KWM1
|
3.1.1.11
|
ACT_SITE 229; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MSRPLIFNLFFLLIAIILPAAAQNWTAGGGRGMRSTVQDEYFKWIRHMGSFKHSLFQNTKNKFKPCLTLKVSKNTKAGGFRSLQKAVNSLPIINRCRVRIHVAAGIYREKVEIPATMSYIWVEGEGAEKTIIEWGDTADHMGENGRPMGTFASATFAVNSPFFIATNITFKNKARLPPSGALGKQAVAFRISGDAAAFISCRFIGAQDTLYDHMGRHYFKDCYIEGSVDFVFGDGLSIYDSCHLHAITNSYGALTAQKRNSMLEETGFSFLHCKVSGSGALYLGRAWGSFSRVVFAYTFMDKIITPTGWYNWGDKNRELTVFYGQYRCSGPGADYGGRVPWSRELTQSEANPFLSLDFINANQWLPNYHTHLSLKPH
| 125 |
G1KG45
|
3.1.3.48
|
ACT_SITE 836; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000927-1"
|
MNNRLRALGGRINNIRASELPKERIRSDIVCNVHFLDGSLQSFKVNKQDTGQVLLDLTFNHMGVTEKEYFGLQHCEESAVSPRWLESDKPIRKQLKGGSSCSLYFRVRFFMPDPNTLQQEKIRHLFFLQLKADILEGRLLCPVNSAVVLASYAVQSQLGDYSASTHLPGYLSDYCFIPEQNKDFLTKVESLHEQHSGLKQSEAESCYINIARTLEFYGVELHSGRDLHNLDLMIGIASGGIAIYRKLICTSFYPWVNIIKISFKRKKFFFQQRQKPSESREHIVAFNMLNYRACKNLWKSCVELHTFFQAKKMLPHEKKLQSHFWTMGSRTPTKSNNQCCRKVIGGMIWNPALRRSLSVEHLETKSLPSRSPPVTPNWRSPRLRHEIRKPKHSSVDNLANEISYITETEDVFYTYKDSSASKDSDSVLCQNLQQRNILENNSAQKSSPQTSNEVSSLQGSHPLGGRDKQFPETNENLAKGLLMDDSNQYYFDKNDVIDGDLLLIHILPDEDGKFGFNLKGGIDQKMPLVVSRIMPGSPSDKCAPKLLEGDQIVLINGRDISEHTHDQVVMFIKASRESHTRELVLLVRRKVIKPFAENKSEDETDSFNFPETILPACSEYGQTLEESMEQLKKGLESGTILIKFEQLYRKKPGLAITCAKLPQNMDKNRYKDVLPYDITRVVLRGEENYINANYVNMEIYSTGIVNKYIATQGPLSHTCVHFWQAVWDHKLSLIIMLTTLTERGRTKCHPYWPDPPDIVEFGNFRIKCRTEDCTIAYVFREILITNIETEEEHTVTHLQYVAWPDHGVPDDSTAFLEFVTYMRPKRIENEPVLVHCSAGIGRTGVLVAMETAMCLIERNQPVYPLDIVRKMRDHRPMMVQTSSQYKFVCEAILHVYKEGIVRPLDSR
| 149 |
O31801
|
3.6.1.23
|
ACT_SITE 82; /note="Proton acceptor"; /evidence="ECO:0000305|PubMed:20823546, ECO:0000305|PubMed:23897460"
|
MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLVPLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDTEIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK
| 189 |
Q5KKV0
|
4.6.1.16
|
ACT_SITE 249; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 257; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 288; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"
|
MSPPPHSIPLYLVNGVATVWDAQTAATLHCVHNVSGLRAGTLPGVAQQNGFLGLPLTLMQEETAYLVTQGIAHLVPLDPSPSPPSDETVKAHTAARVARLKALEEKTREAEAKRLEESKKAFDKGGEKARLKREARARAKAEKAKESGEGLFAEDVKENVTAPIVVSPAKTKTKHAGAPAAGHFHIVPSHPVLSQHPPESQSITSLPHPLFPFPTTPRQCALLGVFSKLQSLSYRVGLGPRFGGEWLIYPGDYLRYHAHFTSQVIVRDEPIRPTEIVAWGRLGTGTKKAGLICCWDDGKREDGQDDQGGKEEDVEFYSLEWANFG
| 207 |
Q8IUH4
|
2.3.1.225
|
ACT_SITE 456; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
|
MEGPGLGSQCRNHSHGPHPPGFGRYGICAHENKELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLWRWLQKCELFLLLMLSVITMWAIGYILDFNSDSWLLKGCLLVTLFFLTSLFPRFLVGYKNLVYLPTAFLLSSVFWIFMTWFILFFPDLAGAPFYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSFIYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLLNQLFQIAFLGLTSHERISLQKQSKHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCVVDWTSQYTMVFHPAREKVLRSV
| 57 |
A0A067DRC2
|
6.3.4.4
|
ACT_SITE 77; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 105; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 205; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134"
|
MNISSVKFNHAGPITGPKWAGFRPTLHLRRNSDVVSFESRTKAGAAPSSLAVTANELPSQIESLSQVSGVLGSQWGDEGKGKLVDILAEHFDIVARCQGGANAGHTIYNAEGKKFALHLVPSGILNEDTVCVIGNGVVVHLPGLFNEIDGLEANGVSCKGRILVSDRAHLLFDFHQEIDGLREAELAKSFIGTTRRGIGPAYSSKVIRNGIRVCDLRHMDTFPQKLDLLLSDAAARFPGLKYTPDVLREEVEKYKRFAERLEPFITDTVHFMNESIAQKRKILVEGGQATMLDIDFGTYPFVTSSSPSAGGICTGLGIAPRVVGDLIGVVKAYTTRVGSGPFPTEIFGQGGDRLRLAGQEFGTTTGRPRRCGWLDVVALKYCCQINGLSSLNLTKLDVLSELPEIQLGVAYKQFDGTPVKSFPADLLLLEQLKVEYEVLPGWQSDISSVRNYSDLPKGAREFVERIEELVGVPINYIGVGPGRDALIYK
| 253 |
C5CPN2
|
2.2.1.2
|
ACT_SITE 126; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492"
|
MNQLDALRQWTTVVADTGDFKQLAISRPQDATTNPSLILKAVQKPEYRPLLDEAVSKHAGKPLDEVIDRLLVRFGTEILSIIPGRVSTEVDARLSFDTAATVARGERIVALYKAEGIDTEKRLLIKVASTWEGIEAARTLEQKGIRTNLTLLFSFAQAVACGAAGVQLISPFVGRIYDWYKKSAGAQWNEAASAGANDPGVKSVRQIFEYYKQHGIKTEVMGASFRNVGQIRALAGCDLLTISPELLAELAASNEPLAHALDAKAATGGDVAKVSYDEAGFRFALNEDAMATEKLAEGIRAFAADAVKLEKLMQESGK
| 52 |
A0A2C9WFA8
|
3.1.1.11
|
ACT_SITE 442; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MKPLNYGRLGPSEPGGSSRSLDQSQFTNSHPSPSRKRKVILLSLLSAALIIASAVSATLLIGLRTRASDHSTPVVARKPTKAISKTCSKTRFPTLCVNSLLDFPGSTTASEKDLVHISFNMTLQHFTKALYLSSGISYLQMDTRVRSAYDDCLELLDDSVDALSRSLSIVAPSMDGNPAGQVQSIGSTEDVVTWLSAALTNHDTCTEGFTDLNGAVKDQMSDKLKDLSELVSNCLAIFSGTDSDDFSGVPIQNRRRLMDAEISKENADDLPSWLGRNERRLLNVPVSAIQADIIVSNDGNGTYKTIAEAIKKAPEYSNRRTIIYVRAGRYEENNLKVGRKKRNLMFIGDGKGKTVISGSKSIFDNVTTFHTASFAATGAGFIARDMTFENWAGPAKHQAVALRVGADHAVVYRCNIIGYQDTLYVHSNRQFFRECDIYGTVDFIFGNAAVVFQNCSIHARKPMAFQKNTITAQNRKDPNQNTGISIHACRLYATPELEAAKASFPTYLGRPWKLYSRTVYMLTYMGDHIHPRGWLEWNATFALDTLYYGEYMNYGPGGAVGQRVKWPGYRVITSTVEASKFTVAQFIYGSSWLPSTGVAFLAGLSV
| 125 |
A0A059BA15
|
1.11.1.7
|
ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MDLELSRVLALLAYCCLMGTGNAQLRFGFYGQTCPSAEPIVRSVVRNAVISNPNMAAILLRLHFHDCFVEGCDGSILIENGRSAERNAFGHQGVGGFEVIEEAKKHLEVTCPGVVSCADIVALAARDAVAMANGPDYEVPTGRRDGRVSNVSLAEDMPDVGNSIQQLKSKFFQKGLTEKDLVLLSAAHTIGTTACFFMTDRLYNFMPGGGSDPSINPDFLPELKSMCPQNGDVNVRMPIDHGSEQTFDDQILRNIRSGWAILESDAKLNDDPVTRSVIESYVGLFNPIFGPSFEAEFVESMVKMGQIGVKTRVKWRDQAGLQIF
| 14 |
A0A1Y1HPL7
|
2.3.1.181
|
ACT_SITE 137; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1"
|
MAHKALQIMRLGRIPYGAGLRIQETLFSLRTQKSVPDTLLALEHPPVYTVILYPILNLHEAKIGARAYVEGLEEVMVQTAGVWGVKARGKVPAETGVWVEDRKIGAVGVRISRGVTSHGLALNATVDLGWFEHIVPCGIADKEVTSLERETGGAEVRFDDVMRESMRAFCRVFGYQHP
| 55 |
B8E1X9
|
3.2.1.21
|
ACT_SITE 324; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
|
MVKYKFPEGFLWGTATASHQIEGDNFYNDWWEFEKQGKVKNGQVSGKACDSWNRYEEDFDLIEKLNNNAYRFSIEWSRIEPEEGRFDESALERYRSMLISLRRRNIEPFVTLHHFTNPLWMAKRGGWLNPDIIDYYLRYVKKIVSEFKDLVNYWMTINEPNAYAFMAYLYGQFPPQGKSLIKMLRVLNNMAKAHAKAYEVIHQISPDAKVSIAYNVIYFEPKNPNSFIDRKFANFGDRIYNRVFIETLLTGKFSSPFIKEEIPYAKNTLDYLGINYYTRILMGLKMGSPEGETSDFGWEIYPEGIYKVVKRFYGLTKKPIYITENGISDAKDEKRPKYLISHLIQLHRAIEEGVDVRGYFHWSLMDNFEWAEGFLQRFGLFETDFNTFERKWRESARIYSEIAKNNGITEAMEEKFLK
| 161 |
F0ZP93
|
3.1.3.48
|
ACT_SITE 86; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50"
|
MNDVSKIFPGFYIGSLPAVNRGNLDKHQITHILSILNEFRPKWTNMYSYLHIDIYDSPSVDIKKYFEKTFQFIEEGRREGAVLVHCFAGISRSATICIAYCMRKLRISFEDAHGLLFDARPIIFPNESFVKQLKKYEAELKEGIIVPISTNLRFKLYSPKYDSDDDESEEDEDDGYDTEEEYEDEEDEESEEEEEEEEEYDNVVKKDKKVNQKATVEQTTASISNISISSSSSSPSSENNDINNNSDNINNTQEETEEESNNNKATLGVYRYCCRKCSTELFLDYDILDHEQGEGQSSFKFHRRDLNLSENKEAAAKKVVCTSFFISEIEFVLNQTGEGMSGKLNCLNCKEKLGSWSWSGEQCSCGQWIAPSFQIPKQRIDEKRITKKN
| 149 |
Q5Z6B1
|
4.6.1.16
|
ACT_SITE 157; /evidence="ECO:0000250"; ACT_SITE 165; /evidence="ECO:0000250"; ACT_SITE 204; /evidence="ECO:0000250"
|
MDLPGPRWKKGKDGKDFASLAAANPMSAIVSELKASFISSKPVAILSGPGGSAVLGVGPEQAVILNRAAFGHAIENATAQKHWFQLSPEEVFYLCHALNCIRVDSLDNKQMSEIELWDYFRSGSESFPEMYKAYAHLRLKNWVVRSGLQYGADFVAYRHHPALVHSEFAVVVVPEGAEFGNRCGRLEVWSDLLCALRASGSVAKTLLVLTISSSSKCELSSPDCLEQLVVHERTITRWILQQCREQRCEPSRDEVNREELIIEKESVVFNHWGVILGFTVLSGLLVYRLKFRQ
| 207 |
K7M080
|
1.11.1.7
|
ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MPLARERENHQISSLKLARYFLFVCMKMDAILGSLMILVMTSAVQAQLKTGFYSTSCPNAEAIVRSTVVSHFSKDLSIAPGLLRLHFHDCFVQGCDGSILIADSSAEKNALPNIGLRGFEVIDDAKSQIEAICPGIVSCADILALAARDAVDLSDGPSWPVPTGRRDGRISLSSQASNMPSPLDSVSVQRQKFAAKGLDDHDLVTLVGAHTIGQTECRFFSYRLYNFTTSGSADPTINVAFLAQLQALCPKNGDGLRRVALDKDSPAKFDVSFFKNVRDGNGVLESDQRLWEDSATQSVVQNYAGNVRGFLGLRFDFEFPKAMIKLSSVEVKIGTDGEIRKVCSKFN
| 14 |
A5PJC4
|
2.3.2.23
|
ACT_SITE 86; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133"
|
MTASKRVAKELEDLQKELPKYLRNLCSEEDNVLVWHALLLPERPPYNLKAFRLCISFPREYPFQPPTVKFTTRIYHPNVDRDGRVCLPIISKKNWKASTRTCQVLEALNMLVNQPEPGQPVRLELAEQLTQDPELFDQMAQEFTLQFGVDRPS
| 64 |
Q95PZ9
|
2.7.11.1
|
ACT_SITE 147; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
|
MSEQRDSRGMPQAGFIIEHQSSDHKWKVLRNIYSGPFSDVYVVADTVTNEKYAMKCERQEGNSRPVLKLDVMVLMATKGLRGFPNFVAAGRTDVYRYCIMQLVGPDLGRLRRTRPERKFSLPTALQILGQTLRRLEDLHNCGWLCRDVKAPNFCIGVGENESTVYILDFGFARKFVDKEGKIIPPRTAAALMGTFQYCAVSAHSHKDQCARDDLESWFYMGIELLKGPLPWANIDGHKNHKQIGEAKVAIRSEPLRSEFFEGVPKQFNEILTILDQTSYFDRPNYKKLGDLLSQAATEHQVTLKEPLDWQNNERMQQKAIFVGELGESHQASAKLDAKDNANESMDIEFDDMPPKEGISKSLSAEKSCTKNVETARTEK
| 99 |
D4ZX35
|
2.1.1.37
|
ACT_SITE 93; /evidence="ECO:0000255|PROSITE-ProRule:PRU01016, ECO:0000255|PROSITE-ProRule:PRU10018"
|
MSNRLSYWEYLHQELKLNADIQSQLVVLDLFAGCGGFSLGFKAAGFQTIGYEMLADAAATYTRNLQDPCYCQTLEIGQDLCNHPDVIIGGPPCQPFSVGGLQKGPRDSRDGLPIFIDAIARYQPEIAIFENVRGMLYKNRQYLEKIVAELERLNYRVDIKLINAVNYGVPQKRERLFVVAYQTAWNWPEAETLAIPYTAGDAIYDTASTIPIGAKFLTPSMLEYIGRYEAKSKCVKPRDIYLDIPCRTLTCRNLSGATSDMLRLLLPDGRRRRLTVREAARLQSFPDWFELVGSENSQFNQIGNAVPPLLAKAIAKSVKMTLENKPSRPTDYFSPFPQQLKLPFA
| 47 |
Q9KRX4
|
2.3.1.286
|
ACT_SITE 112; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01121"
|
MSLPYRHVVILTGAGISAESGIQTFRAQDGLWENHRIEDVATPEGFQRDPDMVLEFYNQRRRKLLSDAIQPNPAHLALGKLEKELQGSVTVITQNIDNLHERGGSQNIIHMHGELLKARCPESNQTVEQKEDIRHGDLCHCCQMPAQMRPHIVWFGEMPLRMGDIYAALEQADLFVSIGTSGVVYPAAGFVHDARMHGAHTIEINLEPSAVESEFAEKRYGKASIEVPRLVEEILAAQARAKESAA
| 58 |
A0A9R1VIC6
|
3.1.1.11
|
ACT_SITE 377; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MSFFRFLLLILFLSTHQTLSRSSPDSASLIRSVCKSTPYPDVCFDSLKLSISININVNVVLQSLQFAINEGVKLLPFLSNTDGNIIEKQKGTIQDCNELHQITLSSLKKSLSRLTTTSSSSSSNKLADAGAFLSAAVTNKNTCLEGLESASGPLKPLLVDTITTAYKHVSNSLSLLSASSSKEKDKSKHHKTTNKGMDLPKWLSGKDRKIFRNDYEDDNDDYDYDYNTLTVANDGSGNFTTITDAINFAPNNSVDRVLIYIKQGLYEENVEIPSYKTNIVLLGEGSDITTISGNRSVIDGWTTFRSATVAVSGEGFLARDIGFHNIAGPEKHQAVALRVNADLAAVYRCAISGYQDTLYVHSFRQFYRECDIYGTIDYIFGNAAVVFQGCNIISRMPMPSQFTVIAAQSRDSPDQQTGISFQNCSILATDDLRDRSSFVTNSTSIPAVKSYLGRPWRTYSRTVFMESYIDNLIDPMGWIHWSSKDEGLESLYYGEYGNIGPGSRVEGRVSWPGYHVMDYNEATNFTVTEFIAGEEWLDSTSFPYDDWV
| 125 |
Q86UX6
|
2.7.11.1
|
ACT_SITE 216; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q60592, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
|
MRSGAERRGSSAAASPGSPPPGRARPAGSDAPSALPPPAAGQPRARDSGDVRSQPRPLFQWSKWKKRMGSSMSAATARRPVFDDKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRLSSLQDVQAAPALAGVLWDHLSEKRVEPGFVPNKGRLHCDPTFELEEMILESRPLHKKKKRLAKNKSRDNSRDSSQSENDYLQDCLDAIQQDFVIFNREKLKRSQDLPREPLPAPESRDAAEPVEDEAERSALPMCGPICPSAGSG
| 99 |
A0A3B3HKM1
|
2.7.11.13
|
ACT_SITE 506; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50"
|
MTLSPCPYHHVFVHLWKQVILGPVTMAPFLRIAFNSYDLGILPPSADKPFCAIKIKEALTTDRGKTLIQKKPTMYPAWKACFDAHIYEGRVLELLLMRTADEALAEVSVGVSVLAERCKKANGRAEFWVDLQPSGKVMMAVQYFLEDVDAESKQAVKEEEAPTLNRRRGAIKQAKIHFIKNHEFIATFFRQPTFCSVCREFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTATNSRDTVFQKERFKIDMPHRFKTNNYMSPTFCDHCGSLLWGLVKQGLKCEDCAMNVHHKCQKKVANLCGINQKLLAEALTQVSQKSSTRRSDPNLPPMPDIGIYDEVNKLAGLELNDASPYGRLWEGCSPRPQSRITHLTRINVDNFIFHKVLGKGSFGKVLLAELKGSGEYFAVKALKKEVVLMDDDVECTMVEKRVLALAWENPFLTHLYSTFQTKEHLFFVMEYLNGGDLMFHIQEKGRFDLNRATFYSAEIVCGLEFLHSKGIIYRDLKLDNVMLNHEGHIKIADFGMCKEDVFGDNRATTFCGTPDYIAPEILLGQKYSFSVDWWSFGVLLYEMLVGQSPFHGDDEDELFESIRMDTPHYPRWINKEAKDLLEQLFDREPTHRLGVVGNIRQHSFFKTINWQALERREVEPPFKPKVKAPNDCSNFDREFLSEKPRLSQSDKNFIDSMDQSAFSGFSFINPKMERLLEN
| 100 |
Q7NND8
|
2.7.1.23
|
ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361"
|
MPAFETVVIAYRAEEAHSRIAADRCESLLHKVGCRVLKGPTGPQDNPYPHFLEATGGHIDLAIVLGGDGSILAAARYLAAVDVPILAVNVGGHLGFLTQPPEVLGGRYWERLLAGEWELEKRMMLQASLTGPPPLPERQPYFCLNEFCLKPASEMRLTSIILELAIDGEIIDQIHGDGLLVSTPTGSTSYTVAANGPIIAPSLQAITITPICPLSLSSRPVVLPATGTIEVSPLRDPDLNIKLWSDGAFAAPVHPCQTVRIEVARHPTRLLILEEDHSYFRTLREKLKWAGTRIQAERDPECLLPPQNHP
| 89 |
A8IAN1
|
2.2.1.1
|
ACT_SITE 463; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1"
|
MQTMLKQRCQPAVGKQAKAVPAVAPKVGRARNVVVAQAAPAAAKAAAPSISRDEVEKCINAIRFLAIDAINKSKSGHPGMPMGCAPMGYVLWNEVMKYNPKNPDFFNRDRFVLSAGHGSMFQYSMMHLTGYDSVPLDQIKQFRQWNSLTPGHPENFVTPGVEVTTGPLGQGICNAVGLAVAEAHLAARFNKPDVKPIVDHYTYCILGDGCMMEGISNEACSLAGHWGLGKLIALYDDNKISIDGHTDISFTEDVAKRYEALGWHVIHVINGNTDVDGLRAAIAQAKAVKDKPTLIKVSTLIGYGSPNKADSHDVHGAPLGPDETAATRKNLNWPYGEFEVPQDVYDVFRGAIKRGAEEEANWHKACAEYKAKYPKEWAEFEALTSCKLPENWEAALPHFKPEDKGLATRQHSQTMINALAPALPGLIGGSADLAPSNLTLMKISGDFQKGSYAERNLRFGVREHAMGAICNGIALHKSGLIPYCATFYIFTDYMRNAMRMSALSEAGVVYVMTHDSIGLGEDGPTHQPIEHLASFRAMPDMLMIRPAGGNETAGAYKVAIANRKRPTTIALSRQNMPNIPNCSVEGVAKGAYTIHDTKAGVKPDVILMGTGSELELATAAAGILEKEGKNVRVVSFPCWELFEEQSAEYKESVLPSDVTARVSVEAATSFGWAKYIGLKGKHVGIDTFGASAPAPTLYEKFGITVNHVVEAAKATLQH
| 51 |
Q55G11
|
3.5.1.23
|
ACT_SITE 298; /note="Nucleophile"; /evidence="ECO:0000250"
|
MINSFKKLIILISLVIILLSSNNIFIDSFKIPVNQKNVKSSGDSSYQIGAGIYDITGASAEVNLMGYANPLQVGAGIHFRQRARAFVFVDSNGNRAVYVSTDSCMIFQEVKIHVVELLQDIFGPNVYTEANVLLSGTHTHSGPAGFSQYALYGITSLGFYKKNFDTICNGIVQAIVKAHKSVQPANMFTETGELWNTNINRSPFAYDNNPEEEKAMYDSNVDKNMTVLRIEDMNGNPFAAISFFAVHCTSMNNTNHLISGDNKGYASYLWEKQVNGPGTAGKGPFVAAFGQSNEGDVSPNTRGPTCRDGSPCDYKTSTCNGRNEECWSLGPGKDGDMFESTQIIGGNQFNKALELFNNASIQVSGPVQYRHSWVQFTNVSVEPPYNSGVDNATTCRGAMGYSFAAGTTDGPGAFNFVQSDNNTSGNPFWNFIGDFIAKPTPDQIRCQSPKPILLDVGMVEPIPWVPDVMPIQIVTIGQIVLVAVPGEFTTMSGRRLRNSVREIIGESIENPIVLIAGLSNTYSGYIATFEEYQVQRYEGASTVFGPHTLGSYMQEFGKLAQSIVDGTTVPAGPTPRNLTGHTLFFLPPVIVDAAPDFDDFGEVSIDVNLNYSVNETVSCVFYGGNPRNDFMIESSFLSVDLLTGTDQWTTVLDDGDWDTKFKWKMHDLGFSLITIEWVIAPDTTPGTYRITHSGFAKKNPFSSNLTPYQGISRNFVVQ
| 182 |
Q9Z0L8
|
3.4.19.9
|
ACT_SITE 133; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00607"; ACT_SITE 243; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00607"
|
MANLGYLLCLLGLLLCGLSSPGMSRPYNHGSERPIIGVVMQECFGKMAKLGNYYIAASYVKYIESAGARVVPIRPDLSDAEYEELFRSINGVLLPGGGANLTDSGYSRVAKIFFSKALESFDNGDHFPVWGTCLGFEELSVLVSGENLLTSTDTKSKKLPLNFTEGARKSRMFKHFPTELLDSLALENLTANFHKWSLSVKNFTENEKLKKFFNILTTNTDGKTEFISSMEGFKYPVYAVQWHPEKAAFEWKNLGGISHAPNAVKTSFYLAEFLVSEARKNSHHFENVVKETASLIYKFNPIYTGNISSFQQAYMFD
| 176 |
Q55535
|
3.1.3.48
|
ACT_SITE 7; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P11064"; ACT_SITE 13; /evidence="ECO:0000250|UniProtKB:P11064"; ACT_SITE 124; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P11064"
|
MKLLFVCLGNICRSPAAENIMNAQIDQAGLGAKIVCDSAGTSSYHVGDSPDRRMTESLKKRGYRVQGRARQFFPEDFAEFDLILAMDGDNYRNILAQDPAGQYHHKVKMICDYTEKFGDREVPDPYYGGQAGFEHVIDLLEDACGNLLTSLGKELVN
| 149 |
O81832
|
2.7.11.1
|
ACT_SITE 590; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
|
MEATNVLHLLIISLFSTILLAQATDILIANQTLKDGDTIVSQGGSFEVGFFSPGGSRNRYLGIWYKKISLQTVVWVANRDSPLYDLSGTLKVSENGSLCLFNDRNHIIWSSSSSPSSQKASLRNPIVQILDTGNLVVRNSGDDQDYIWQSLDYPGDMFLPGMKYGLNFVTGLNRFLTSWRAIDDPSTGNYTNKMDPNGVPQFFLKKNSVVVFRTGPWNGLRFTGMPNLKPNPIYRYEYVFTEEEVYYTYKLENPSVLTRMQLNPNGALQRYTWVDNLQSWNFYLSAMMDSCDQYTLCGSYGSCNINESPACRCLKGFVAKTPQAWVAGDWSEGCVRRVKLDCGKGEDGFLKISKLKLPDTRTSWYDKNMDLNECKKVCLRNCTCSAYSPFDIRDGGKGCILWFGDLIDIREYNENGQDLYVRLASSEIETLQRESSRVSSRKQEEEDLELPFLDLDTVSEATSGFSAGNKLGQGGFGPVYKGTLACGQEVAVKRLSRTSRQGVEEFKNEIKLIAKLQHRNLVKILGYCVDEEERMLIYEYQPNKSLDSFIFDKERRRELDWPKRVEIIKGIARGMLYLHEDSRLRIIHRDLKASNVLLDSDMNAKISDFGLARTLGGDETEANTTRVVGTYGYMSPEYQIDGYFSLKSDVFSFGVLVLEIVSGRRNRGFRNEEHKLNLLGHAWRQFLEDKAYEIIDEAVNESCTDISEVLRVIHIGLLCVQQDPKDRPNMSVVVLMLSSEMLLLDPRQPGFFNERNLLFSDTVSINLEIPSNNFQTMSVIDPR
| 99 |
Q8L7U5
|
3.1.3.16
|
ACT_SITE 651; /note="Proton donor"; /evidence="ECO:0000250"
|
MGSKPWLHPAPQYKTLETFWDDEDDAPGPRCAHTLTAVAATKTHGPRLILFGGATAIEGGSSSVPGIRLAGVTNTVHSYDILTRKWTRLKPAGEPPSPRAAHAAAAVGTMVVFQGGIGPAGHSTDDLYVLDMTNDKFKWHRVVVQGDGPGPRYGHVMDLVSQRYLVTVTGNDGKRALSDAWALDTAQKPYVWQRLNPDGDRPSARMYASGSARSDGMFLLCGGRDTLGAPLGDAYGLLMHRNGQWEWTLAPGVAPSPRYQHAAVFVGARLHVSGGVLRGGRVIDAEASVAVLDTAAGVWLDRNGQVTSARGSKGQIDQDPSFELMRRCRHGAASVGIRIYVHGGLRGDVLLDDFLVAENSTFQSDISSPLLASDRTQQSSTPRFSYAARPPSGSEPSFSMSEGLSLDENSLEKLTEASAAEAEVASSVWRAAQLGAGTLDEEPSTSDASSPIVESTTDGTANEGDVRLHPRAVVVAKETVGSLGGMVRQLSLDQFQNESRRMVPMNNSDVPQPTKKFTRQKSPQGLHKKVIAALLRPRNWKPPGNRKFFLDSYEVGELCYAAEQIFMHEQTVLQLKAPIKVFGDLHGQFGDLMRLFDEYGFPSTAGDITYIDYLFLGDYVDRGQHSLETITLLLALKIEYPENVHLIRGNHEAADINALFGFRLECIERMGENDGIWAWTRFNQLFNYLPLAALIENKIICMHGGIGRSISTVEQIEKIERPITMDAGSLVLMDLLWSDPTENDSIEGLRPNARGPGLVTFGPDRVTEFCKRNKLQLIIRAHECVMDGFERFAQGQLITLFSATNYCGTANNAGAILVVGRGLVIVPKLIHPLPPPILSPENSPEHSGDDAWMQELNIQRPPTPTRGRPQPDFDRSSLAYI
| 144 |
A0A1D6IKW0
|
1.11.1.7
|
ACT_SITE 118; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MATKLAVLATLVLALLGPVSCQQQQAGYGYGAGSPTPTSSPPPPAAYPPMTTSPTPSSPTAYPPPPPPTPSPPPPAAGAGLSVGYYKDKCAEAETIVQEAVRAADAGTKAGLVRLFFHDCFVQGCDASVLLKPDNDTNPQPEMLGVPNLSLRGFEVIDAAKAAVEARCPGVVSCADIVAFAGRDASAFLSGGAINFTMPAGRYDGTVSLANETLPNLPPPFADVRRLKAMFAAKGLDTVDMVALSGAHSIGRSHCSSFSSDRLPPSNTSDMDPAFAATLQASCASSANGAADNTVVQDYRTPDQLDNQYYRNVISHKVLFASDAALLKSSDTLGLVYVAAFSQKLWQDKFGQAMVKMGGVQVKTAANGEIRRMCGYVNKP
| 14 |
O25849
|
2.3.1.286
|
ACT_SITE 104; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01121"
|
MKNLVILSGAGISAESGIKTFRDADGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVNIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQNVQCINESAVHAMQDLMPKLIEMAS
| 58 |
A0A2K1KP88
|
1.11.1.7
|
ACT_SITE 123; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MISRNAEAKKIRTKRGGVSKFASAWECSFNGRRKVLQVGAPDAAPPQQLEAPSPSAPSSPPLPPQSTVATRPTGADVHGEPPLDYDFYTKSCPSFQQIVKTQVARAILADSLTPAKLLRLFFHDCFVMGCDASLLLNSTVVNLAERDHANNFTVDKYSVIDSIKAELEKACQAIVSCADTLGAAAAEAVEQAGGPHVDLAYGRRDGLESFAPAAKTNLPAGTLQVAGLLENFQNVGLNLTDVVVLSGGHTIGQARCSSFADRFTPGVKNPFPDVSFGENLYTYCVEGNTIGLDRRMSLDTNSTTVFDNGYFRSLVAGRGILTSDNILFTDPRTKPLVTQFAENQDAFFTAFKESMAKMGRIVVLTGTQGQIRKQCWVRNPIDANLRPEANMDFAPQSTKFCRQKPCNPTCSDPAS
| 14 |
Q6P0S1
|
2.7.7.7
|
ACT_SITE 304; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50"
|
MEGHGHGILKAFPKVKRARPNDQKDAPPSKRTPAESITLTGTVFQGVTIYIVPAGIGKARCDIFHRQITQNGGQAVSTFAPSCTHVVVDDSVDFKRALRLLKVDTLPSAVHLIKCTWLSACISEKRLLDTEDYSLRPPESPTVAAAEKSNEATIQPVPEVAAQDPLQILDNLDPHENLTETIPPETQEEYHEEDGVSQNDLEALISGVHPSESNQDQKQSSADKPVLPGKWVCSQPSTTKGENHNKHLTDKLEPLAKAYTHTGDKWRALGYSKAINALKSYHKPITSYEEACKIPGIGKRMADKIMEIMESGHLRKLDHIGEEVPVLEMFTNIWGAGAKTAQMWYQQGFRTLEDIRTKAVLNHTLRIGLKHYDDLLERMPRSEANAIEKTVKDAAHSVDPQLLAMACGSYRRGRSTCGDVDVLITHPDGQSHKGVFSKVLHLLHQSGFLTDDLVSHEENGEQKKYMGICRLPGPSQLHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKNMSLSEHSLNCAVIRQRGVKLVAGTPLHTPTEKNVFQHLGIPYREPHERDW
| 121 |
A0A9R0HST2
|
2.7.1.11
|
ACT_SITE 214; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186"
|
MEPKIVTGEGGYALDDVPHFSDYLTNLPTYPNPLQTNPSYSVTKQYFVDFDDTVVQKAVQHKDGPRGIHFRRQGPRQKVYFKPDEVTACIVTCGGLCPGLNTVIRELVCGLDYMYGVKNILGIECGYKGFYARNTLPLTPKTVDSIHKRGGTILGTSRGGYVTSKIVDSIQDRGINQVYIIGGDGTQKGASVIYQEVRKRGLKVAVVGIPKTIDNDIPIIDKSFGFDTAVEEAQRAINAAHTEAESVENGIGLVKLMGRDSGFIAMFATLASRDVDCCLIPESPFYLEGEGGLYEFIGRRLRENGHMVIVIAEGAGEKVEERDPSGNKAFKDVGLWLSFMIKEHFAKTKLNITLKYIDPTYMIRAVPANASDNVYCTILAQSAIHGAMAGYTGCTVGPVNGRQCYIPFYRVIEKPNKVVITDRMWARLLSSTNQPSFMHPPKGAIIEGKQDEVVLSESAAEESNENEKCTPTSTSLSIHDNHVDDQYSMSNGSSELLLK
| 84 |
O43063
|
3.4.25.1
|
ACT_SITE 25; /note="Nucleophile"; /evidence="ECO:0000250"
|
MATTVKDTMNVDINAIKKGEIRMGTTITALRYKDGVILAADSRTTMGAYIANRVTDKLTQLTDNIWCCRSGSAADTQTVADLLKYYLSMYRIQFGHDPSVHTAATLASEMCYQNKNMLSAGLIVAGYDEKTGGDVYSIPLGGSLHKQPLAIGGSGSAFIYGFCDANFRENMTQEEAVEFLKNAVALAMERDGSSGGTIRMVILNKDGMERKFFAIDTANPIPVFTH
| 180 |
E9Q612
|
3.1.3.48
|
ACT_SITE 1146; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044"
|
MGHLPRGTLGGRRLLPLLGLFVLLKIVTTFHVAVQDDNNIVVSLEASDIVSPASVYVVRVAGESKNYFFEFEEFNSTLPPPVVFKATYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVLFEIHYPEKYNVFSRVNISYWEGRDFRTMLYKDFFKGKTVFNHWLPGLCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPRNISVRFVNLNKNNWEEPSGSFPEDSFIKPPQDSIGRDRRFHFPEETPETPPSNVSSGSPPSNVSSAWPDPNSTDYESTSQPFWWDSASAAPENEEDFVSALPADYDTETTLDRTEKPTADPFSAFPVQMTLSWLPPKPPTAFDGFNILIEREENFTDYLTVDEEAHEFVAELKEPGKYKLSVTTFSSSGACETRKSQSAKSLSFYISPTGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPVIENLVPGAQYQVVMYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPILGVFRKYVVEMFYFNPTTMTSEWTTYYEIAATVSLTASVRIASLLPAWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDATTDLSHSRMLHWMVVAEGRKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSLPRLVKLEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQLGSGHNGKLQEPVAVSSHVVTISSLLPATAYNCSVTSFSHDTPSVPTFIAVSTMVTEVNPNVVVISVLAILSTLLIGLLLVTLVILRKKHLQMARECGAGTFVNFASLEREGKLPYSWRRSVFALLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDSYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSHIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMVSEEEEEDWASRHFRINYADEAQDVMHFNYTAWPDHGVPPANAAESILQFVFTVRQQAAKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWLRKKQQFCISDVIYENVSKS
| 149 |
A0A251SZI7
|
3.1.1.11
|
ACT_SITE 413; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MIKQLFSGVSDSGKKKKIFIAVFASILLIAAVIGIVAGVNSKTTNTQSDNIRASAAHTIVKSSCSITLHPELCYSTVASVPGMTEKVKSLRDVIELALEKTKERVQTNKLIIKTLAARRNLTKRGKIAVHDCLEMVDDTLEELDLVIDYVKNYATRKGIRKHVDDIITYLSTTITNQQTCIDGFSHNKPDRHLRQSIIGGEDNAGKLCSNSLALVKNMTDTDMANEVQTNTNTRKLMNEDDENWPEWLSAGDRRLLQSGNVRANVVVAADGSGNFRTISQAVAAAPSRSSSRYVIRIKAGVYRENVDVPSSKTNLMFLGDGQTKTIVTASRSVGGGSTTFNSATVAVVGAGFLARGITFQNTAGPANEQAVALRVGSDKSAFYECGFIAHQDTLYVHTNRQFYTNCYVAGTVDFIFGNAAVVLQNCDINARRPGPSQKNMVTAQGRTDPNQNTGIVIQKCRIGATSDLKPVQGTFPTYLGRPWKEYSRTVVMQTTIGNVIHPNGWFPWDGNFALNTLYYGEYQNNGAGSSTSNRVRWGGYRVITNAAEARGFTPGNFINGGSWLGNTGFPFSLGL
| 125 |
P45142
|
5.4.99.25
|
ACT_SITE 48; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_01080"
|
MSRPRKRWRDVDGVFLLDKPQGMSSNDIMQKVKRLFQANKAGHTGALDPLATGMLPICLGEATKFSQFLLDADKRYLVTAKLGERTDTSDAEGQVVETREVNLETQQILTALEQFRGDILQVPTMFSALKHNGKPLYEYARQGITVEREARPITIFELNFIEYNAPFLTLEVHCSKGTYIRTLVDDLGEVLGCGAHVTMLRRTAVADYPVAEMMPINELQLLAESFPLSELDRLLLPTDTAVSKLPALHLDAEQSKAIGFGQRVKFANEQQLSGQVRLFSAENLFLGVLNRREYYSPTTINYTIRITSLPFL
| 218 |
P53965
|
3.6.1.52
|
ACT_SITE 214; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000305|PubMed:29540476"
|
MGLYQAKNDEGSDPKSSSKIDDLIENEAEIIRLIKEDGKLLIDNGDGRDIHNIIQEDKLLSVEFNEVLKRFHGEEKSDIPRKEFDEDEDDGYDSNEHHQKTIEVMNTLNHVINKEVIPPENFSHVVGEIYRSSFPRQENFSFLHERLKLKSILVLIPEEYPQENLNFLKLTGIKLYQVGMSGNKEPFVNIPSHLLTKALEIVLNPANQPILIHCNRGKHRTGCLIGCIRKLQNWSLTMIFDEYRRFAFPKARALDQQFIEMYDDDEIKRIASKNNWLPLQW
| 190 |
A0A9R0K962
|
3.4.21.89
|
ACT_SITE 154; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 204; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
|
MTSLHLLPPISSLSNSTSKKSPKPIKNPNFTILNLHPCSIPLQFNKTPFNSHLKTPNSLSSNPLKPLNSLICRSLKESQDDTKTTLSTKSGGGDGGGGGGDGEGDDGNKGDSSSLLPEWLNFTSDDAITVFAAVAVSLAFRSFIAEPRFIPSLSMFPTFDVGDRLVAEKVTYYFRKPCPNDIVIFKSPPVLQDVGYTDNDVFIKRVVAKAGDTVEVKDGKLIVNGVVKDEAYIFESPKYNMTLTRVPENSVFVMGDNRNNSYDSHVWGPLPAKNIIGRSLFKYWPPNRIGSTVLPEGCAIEKQESPSTSS
| 178 |
H9GCN5
|
2.7.10.1
|
ACT_SITE 744; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
|
MVLRLPSVKACLSFELLLLLWVSLLCEVAGKEVNLLDTSTAQNELGWLPDPSESGWSETQHMINGTPVYMYQDCSVLSEGDTDHWLRTNWIIRDVASSNIFVELKFTIRDCKSFKGEVVSCKETFNLYYMESDNDVGIQFRRPLFTKINTVAGDRSFTARDIASGDMQLNMEVSSIEKLHQRGFYLAFQNSGACVALVSVRVYYKTCSESVHGLAHFPETLASSEGLETVFGTCLKDAAEKPGFPPKMHCSSNGEWLLPMGQCICVIGFEEVEGACVGCQPGFYRHSLETEKCLKCPPNSFSSSPAATACPCHKGFFRTPTEDQTIACTRPPSAPHNVTSSLVGSQVSLTWQPPIDQGGRSDLSYNVSCKRCHFLVCEPCESDVVFSPRALGLTRTNVVVDGLESYTNYSFTVRAYNGVSGLSSASHKSTSSSVWVTVGYADPIIVTNINLDSQNESSLSVTWLPTRHRSHVPISYEVMYFEKGEEKHYTVQHLKEPKVTLANLQPDTSYLLRVRSVTPSGEGPFSQEQEFRTLPQETGIPSGGMIVCIIFGILLFIGLVGGLIILRRRQAHRRARPCQKHSSYNRDDIWLKPYVDLQPYEDPSRGVLEFTKELDPSLVNIENVIGEGEFGEVYRGSLRFPGKDHIVVAIKTLKSSYSDSTWWNFLREATIMGQFNHPNIVRLEGVVTKRNPMMIITEYMDNGALDNFLRENMDKFSAVQLVIMLQGIASGMTYLSDRNYVHRDLAARNILVSHSHQCKVSDFGLSRILENDVEGTYETKGGKIPIRWTAPEAIAHRIFTSASDVWSFGIVMWEVFSYGDKPYGDMSNQEVMKSIEDGYRLPPPVDCPSVLYELMKACWSYDRARRPRFREIQAQLDHFISSPHLLRSVADFDPRVTLRLPSCSGSDGIPYRSIPEWLESIRMKRYILNFRTAGLNTMESVLELTAEDLKQMGVTLPGHQKRILCSIQGFKE
| 97 |
B8CBQ0
|
2.3.2.26
|
ACT_SITE 314; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
|
MSLSRKDLRKVWRFEFIGEAGIDAGGLAREWFELVTEEVFDPDMGLWQTSATNQMCMQINPASEISCPDDHLIYFRFIGRVMGKAMFDRQLVKGHMVKHLYKHILGWPIMFNDLKDIDEEYYNSLKGLKDMGADVEYVGVDFTVMEETLGVKSTVDLVPDGANIDVTEDNLPEYIEACLKYRMLGRYEAQLNELLLGFFDVIPEPLLTIFDFQELELLMCGLPEIDMQDWQDNTEYSGEYDRDGPNHEVCRWFWEIVSEYDHEMRARLMQFVTGTSGVPARGFGSLQGNDGNVRKFTIHGVSLETCVYPRSHTCFNRIDLPLYEDRDDLEEKLKIAITMASTGFDIE
| 65 |
A0A059AJM6
|
1.11.1.7
|
ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MARMTNRAAVDVMWGVMLLMQMMGLIRSFNFGIGGVDGLRMDYYFMSCPFAEQIVWNSVTSALQSDPTLAAGLLRMHFHDCFIQGCDGSVLLDSTKDNTAEKDSPANLSLRGYEVIDDAKEQIEEQCPGVVSCADILAMAARDAVFWAGGPRYEIPKGRKDGARSRIEDTINLPSPTFNASELIRMFGQHGFSAQEMVALSGGHTLGVARCSSFKQRLSNSDPTLDSSFAKTLSKTCSAGDNAEQPFDATRNTFDGAYYYGLVNKVGVLTSDQTLFASARTKGIVNGYAMNQAMFFFDFQQAMLKMSLLDVKEGSAGQVRLNCRKIN
| 14 |
P0C1B3
|
3.2.1.1
|
ACT_SITE 227; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:9283074"; ACT_SITE 251; /note="Proton donor"; /evidence="ECO:0000305|PubMed:9283074"
|
MMVAWWSLFLYGLQVAAPALAATPADWRSQSIYFLLTDRFARTDGSTTATCNTADQKYCGGTWQGIIDKLDYIQGMGFTAIWITPVTAQLPQTTAYGDAYHGYWQQDIYSLNENYGTADDLKALSSALHERGMYLMVDVVANHMGYDGAGSSVDYSVFKPFSSQDYFHPFCFIQNYEDQTQVEDCWLGDNTVSLPDLDTTKDVVKNEWYDWVGSLVSNYSIDGLRIDTVKHVQKDFWPGYNKAAGVYCIGEVLDGDPAYTCPYQNVMDGVLNYPIYYPLLNAFKSTSGSMDDLYNMINTVKSDCPDSTLLGTFVENHDNPRFASYTNDIALAKNVAAFIILNDGIPIIYAGQEQHYAGGNDPANREATWLSGYPTDSELYKLIASANAIRNYAISKDTGFVTYKNWPIYKDDTTIAMRKGTDGSQIVTILSNKGASGDSYTLSLSGAGYTAGQQLTEVIGCTTVTVGSDGNVPVPMAGGLPRVLYPTEKLAGSKICSSS
| 157 |
Q67IX6
|
5.3.4.1
|
ACT_SITE 102; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 105; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 444; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 447; /note="Nucleophile"; /evidence="ECO:0000250"
|
MRSRSLLLVALATLLLHASASASDDDLDYLIDNADDIPANDPDGWLQEGSPDDDDDDDLFHHGQAQDHPIDETHVFLLSAANFSDFLASHRHVMVEFYAPWCAHCQALAPDYAAAAADLSPLAHQVALAKVDATEDTDLAQKYDVQGFPTILFFIDGVPKDYNGARTKEAIVSWVNKKLAPGVQNITTVDEAEKILTGEDKAILAVLDSLSGAHSDEIAAASRLEDAINFYQTSNPDVAKLFHLDPAAKRPSLVLLKKQEEEKLTFYDGPFKASAIADFVSANKLPLVNTLTQETAPSIFDNPIKKQILLFVVANESSKFLPIFKEASKSFKGKLLFVFVERDNEEVGEPVANYFGITGQETTVLAYTGNEDARNFFLDGEISVENIKRFAEDFLEEKLTPFYKSEPVPESNEGDVKIVVGKNLDQIVLDESKDALLEIYAPWCGHCQELEPTYNKLGKHLRGIDSLVIAKMDGTANEHPRAKPDGFPTILFYPAGKKSFEPITFEGDRTVVEMYKFIKKHASIPFKLKRPDSSATKTEKDQSTASTNLRGERSSGTNFKDEL
| 215 |
P29340
|
2.3.2.23
|
ACT_SITE 115; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133"
|
MPNFWILENRRSYTSDTCMSRIVKEYKVILKTLASDDPIANPYRGIIESLNPIDETDLSKWEAIISGPSDTPYENHQFRILIEVPSSYPMNPPKISFMQNNILHCNVKSATGEICLNILKPEEWTPVWDLLHCVHAVWRLLREPVCDSPLDVDIGNIIRCGDMSAYQGIVKYFLAERERINNH
| 64 |
B6K5F9
|
2.2.1.1
|
ACT_SITE 421; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1"
|
MVSTYTDLDTKAVNTIRTLAVDTTCKSKSGHPGAPMGMAPAAHVLFSRIMNFNPQKPRWINRDRFVLSNGHACVLQYALCHLLGYNLTIDDLKNFRQLGSKTPGHPENHNPDLCIEVCTGPLGQGITNAVGLAIAQAHTAATYNKPGYDLINNRTFCFLGDGCLQEGVSSEASSLAGHLKLGNLVAVWDNNKITIDGSTDVSFDEDVEKRYEAYGWQVLRVADGDSDYASIEQALLDAVACKDKPTLINMKTTIGYGSMKQGTHSVHGSPLSAEDAAHVKREFGFNPEQSFYVAPEVYDLYKKHVARGVEAQQKFDELFAKYKTEYPELAAQFERVVEKKLPEGWEKKLPTYKPTDPAIASRKLSEIVLDSIAPVLPELVGGSADLTGSNLTRWKGAVDFQPKESNLGDYSGRYIRYGVREHAMGGIMNGMAAYGTVIPFGGTFLNFVSYAAGAVRLAALGQFRTIYVATHDSIGLGEDGPTHQPIETYAHFRAMPNINCWRPADGNETSAAYHSAISLAQTPSILALTRQNLPQLNGSSIEKALKGGYVLVENKDANVTLIGTGSEVSLCVEAAKVLEAEHGLKARIVSMPCCEIFDEQAQEYRLSVLPDGIPIMSVEVYSTVGWKRYAHEAFGIDSFGDSAPYQQLYAKYEMTPEGVAVRAKMTVDAWKPVQNIRSPIHHAF
| 51 |
Q8IL26
|
2.7.11.1
|
ACT_SITE 660; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
|
MTSEDKTALCAENILNDIYILTINRNIDIDIIQEGLLRKVMDEEESNSILFLEDSSFSKNDISILNVHLKIEDGKNKYNNYYEFKYADINVTIDFYQKECKYSIEKSNMHKCHYFKMMNKINYITEQKMDFKDSILYLYNTINDKNFFKCPCWLNDNKNIKLNNIINDHQQKKKKKNLYDKSVQVTNDVTNIMVNEIQEQKMKKPIFFDNKNDLNNSDDEFNSAHSSLIKINKLLNVEENDIFHNLKGHVYEEYFDKHEDNKNQKDNIESNIIVKDKKDRANNIISEQMKEDYIKNVEEVLSKHINNNKNNNVEDSVSLYSLDEEISEQIDKQHFFSIDKRQDEISNFIQMEENINDHMNDNINKMGKKKHGKENRVVEDEKYIQDDKKKKRFYRNVNDNIPLTVQLANKGNEICKEIIEMNSRYYRDFFEEKILGCGGFGYVMKVKNKKFNITYALKIIRLSNSKYNTQTNNKHINEKDNNSYIMEEAIMIAKLQHENIVRYYDAWVEENVDFFLYKELQNEFKNIKIKIKNEKMKNEKMKNEKIISGKIKNENIKSENIKSENIKSENIKSENIKSEKVKNLYIEEIKYFWNHYKKNKDPNVNDKYLYILMEYCPGKTLREAIDCGFICRNEKLIWELIKQILKGISYIHDMKIMHRDIKPSNIFLQITDNILIAKIGDFGLTTRIGDTQINPSAGTIHYISPEQLNGEPFNEKADIFSLGVVFFEMFHEPFSTSMERSITLSNLLKGIYPEYMKADNKKFQFLSSLLAINPQERCCAYNLLHESVLFTFEKDFTDIYNLIDNKRNCEEVHTIISTLFDKFEYLNSDKILKKEDFSTFQNAKIFTDDLEMRKKQKIIKKKILISLKKRGAIFILTPIILLNKYYINLENTYMEEYNIYYNINKKKENKINNIYINTNKNKNIDNLIYMLDIYGNSITLRNSFFLSFAEYIYESIDSYNKYNEDNLFYKFYTYGYTYKNQIIKSNKHIKKDTINNNINTTINITTTTCNTTTGTSTNNNNNNNNNNMGNNNIGNNMGNNVSNIISNNNINNHMISNNPFYFYNIYPDENEKMFYCILSSSKNVFGNEELNYLSIFSNADIMVSIYTLYNHINYFNKLLFVWSYIDLLEIILKECLDIPNDISYHLSIDLKKNSTLLVNKSFVMSLLQKYKIKDMSKISDHILSLFYIKCESNKVDDYLNNIYNFVDDLLNKKSSLQLKRNTSITPKEVPYVRSRSNNISTSASKIIKYDIQKNVGTKEKGNQNDNEKKKMQIYSILDRIKKINNFICTNTVINNTCFDLFLNYEESIFCNEVIFYVICESKNKEIIAYGGRFDEIIRNMANEVKYKNHANYKYVYNNIKDIYNNNNNNNNNDNNIMNIKAYGVEIYLDKIYSKVIESNEKISIHLQYNPSTDKSQLFKNFVTSCQQNDFACTSHIIQQPLLNDDYLNYSSTKILIQVYEISNLLIAYDLSKKLLTKNISSYTHLSINNVNIKKKIKNFKPHKIQFFITIKSNNTDNSFDALKPINFDNVVYKIVNYDDQDCNFMDQAELINYLIKYF
| 99 |
A0A2K2B4M4
|
2.1.1.37
|
ACT_SITE 833; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
|
MKSSSSPTDSRKLTPLQVYESTSTSRRSPRLAPPNNNVPSKTPKSNKPKTTHISLRRSPRLEPTPASPQSVSRKKHSRNVSKTKCSARNVSVDRKIPSRSSRVGNSRMQNVAANRTVLLDSSALRRSPRLSSADMEIVVSERNASVVVADTARLRRSPRLANGYAEVAVSKVRTFLKRKRVSDEMSRSPRNQNGRLDVQFALVQSEKCSRFIVNEENERNCLKVECSSKDLSKGSPVACSSANAKLGCCEKRGCQSVLLTISDSEVGDSGEFEAKPLLLPWHGDNESQTGMVKCDDGSSVFEEEPLRMSPSFDFANENAVINESPIKSCKWSSALDGDGNFEVISCSSGIFDSNDACPSKRVKICEENSVSGMSDEKLLRRSPRTNSIVVTENGENKSGKKQSPKTNSGKELSLEKASSGKKQKEHRGNCSLIGDPVAHDEAQERWHWRYEMKSKRTKHPRLALDDDDEDKVVWNVECHYTQANIEGRIINLGDCVYVKGEGAKNHIGSILEFFKTTDREDYFRVQWFYRAEDTVMKEAADFHDNKRLFYSTVMNDNPIDCIISKVTVVQISPRVHLKFHSTPASDFYFDMEYCVDYSTFRTLLTDCSLRGHELSPLPFCDSRSATPSDISMENMSTCGSYKAKLTLLDLFSGCGGMSTGLCLGAKVSCVDLVTRWALDSDESACQSLKLNHPETHVRNEAAEDFLELLKEWQKLCKRYAVNDVGRTHKSRSMASSMSKQNKNSSNDDDIASGEYEVARLVDICYGKTDKRGKRGLKFKVHWKGYSTSEDSWEPIEGLSNCEHSIRDFVREGFKSKILPLPGDADVICGGPPCQGISGYNRYRNVDSPLADERNIQIVVFMDIVQFLKPKYVLMENVVDILRFDKASFARYALSRLVHMKYQARLGTVAAGCYGLPQFRLRVFLWGAHPKEKLPQFPLPSHDVIVRYWPPPEFERNTVAYDEDQPRDDLEKATVLRDAISDLPDVTSHETREEMAYDKPPETDFQQFIRSTRNEMTGSELSGTRMINLLYDHRPYSLTEEDFARVCQIPKKKGANFRDLPGVVVGADNVARRDPTEEQMLLPSGKPLVPDFALNFEGGKSRRPYARLWWDETVSTVVTFPDLHSQAVMHPEQDRVLTIRECARLQGFPDYYRFCGTVKQRYRQIGNAVAVPVGRALGFTLGMAFQKLSGDDPLMTLPPKFSHSTNLQLAKSLFQKAE
| 47 |
P0AF24
|
3.1.3.5
|
ACT_SITE 9; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:16430214"; ACT_SITE 11; /note="Proton donor/acceptor"; /evidence="ECO:0000305|PubMed:16430214"
|
MTIKNVICDIDGVLMHDNVAVPGAAEFLHGIMDKGLPLVLLTNYPSQTGQDLANRFATAGVDVPDSVFYTSAMATADFLRRQEGKKAYVVGEGALIHELYKAGFTITDVNPDFVIVGETRSYNWDMMHKAAYFVANGARFIATNPDTHGRGFYPACGALCAGIEKISGRKPFYVGKPSPWIIRAALNKMQAHSEETVIVGDNLRTDILAGFQAGLETILVLSGVSSLDDIDSMPFRPSWIYPSVAEIDVI
| 150 |
A0A7I4EL45
|
2.2.1.1
|
ACT_SITE 567; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1"
|
MEATAAAMAMQKSPGAPRALNEGTQVRVPASRSVVSGAALPRCSQPAACLSKATQTSKWTGNWKPEKLAKLREANPFASFRRGLKMPHGARADSQSLQDEQVKTGQPGTQKQSVPSKIVDRKESSTPKEHMKAWKEEITSMLGGKEGNWEDSKWFQSQIDKRCVDNMRMLTVDAVNTAKAGHPGLPLGMAEVGYVLWRYVMKFNPKNPNWFNRDRFVLSAGHGCLLQYITLHLSGYDSVQIEDLKRLCQIGSRTPGHPENVTTDGIEVTTGPLGQGVANAVGLALAEKHLAARFNKHDGKIVDHRTFCIMGDGCAMEGITNEAASLAAHWKLNKLTVIYDDNHNTIDGDTSLAFSEDVGARFEALGWNRVVIDNIYHDIDSFKEAVLNFAGKSDKPTFIQVKSRIGRESVKENTAKAHHGTFDEDDVKHMHKNLKWENREPFYVIPQVYEEFTDHAKHGISEEEEWNEALEDYSKKYPEEARNFKELISGELPKDWEKAIPHFPEDEKIDATRGYSETCLNAVAKVLPGLIGGSADLASSNKVYMKDFPDFSAETPEGRNIRYGIREHAMAGISNGLALHNSGLIPIAATFLIFSDYMKNSMRLSALSEAGVIYILTHDSIGLGEDGPTHQPVEQLAGLRAIPGMYVLRPADAKEVAGAYKVAISRRHAPTVLSLSRQKVAANVGGTSAEGVLKGGYVVSDNTDENSLPELILIGTGTELALCEKSAETLRQEGKKVRVVSLVCWQLFDQQPEEYREKILPSAMEKRISVEAGSPFGWREYVGSKGKILAVYTFGCSGAYTKVFEKYGFTAENITDVAQKLLTETETRNQN
| 51 |
B9RK96
|
3.5.4.5
|
ACT_SITE 79; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006334-1"
|
MEPPRFVIEASEAESMAQKAGLTLVELLPTLVKSAQSLARPPISDYYVGAVGLGSSGRIFFGANLEFPGLPLHQSVHAEQFLITNLFLNAESNLKYVAVSAAPCGHCRQFFQEIRDAPDIQILITGDSNNTNNNDQSNGDIKRFDTLSNLLPQRFGPYDLLDKSVPLVLEKHNNHMSLQNDDISNNSKKVPNGISISVFDDLKLEALEAANSSHAPYSKCPSGVALMDCEGKVYKGSYMESAAYNPSLGPVQAAIVAYLVGGGGGYEKIVAAVLVEKEEAVVRQEFTARLLLQVISPRCEFKVFHCSSSKS
| 187 |
A0A8V0ZFG5
|
3.1.1.4
|
ACT_SITE 67; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 111; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"
|
MNALLALAILFAWGSSLAGGSLWQLQEVVTKMTGKNAVLNYSSYGCYCGVGGHGQPKDATDRCCQLHDTCYDSLQRYHCNAKKQRYKYSWHSGRLTCNRDSWCAQLSCECDRSLGLCLQRNRRSYNWRYVLYPRCKCR
| 130 |
A0A078F6G3
|
1.11.1.7
|
ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MAIKNLLVLAVLLSVLGVSVANSKGLDLNYYKHRCPDVETIVRRTTVQYVSRQPSLAAALLRMYFHDCFVRGCDGSILLKSPNKDAERDAIPNLSVRGYEVVDAAKAALEKKCPGLVSCADSPETLFNAFFSQINGPWWPVPLGRRDGRISRKSEVNLPSPFAGIAALKKNFFDKGLNTKDLVVLSGAHTIGISNCGLINSRIYNFTGKGDFDPSMNPSYVRALKKRCKPTDFRTSVEMDPGSVKKFDSHYFNIVAQKKGLFTSDSTLLDDPDTKKYIDTQVATAGSSFNKDFSESMFKLGFVEIFTGNKGEIRRKCAFVN
| 14 |
A0A6I8NME7
|
2.3.2.26
|
ACT_SITE 1298; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
|
MARRLRLHFAARRRNTDPLSESSGDDLDDNPPMCFRRPSPAPASNTVQMKLTPRQTVLPPGAREIVRSQEGSAAPSSQSRHKKSTFLQISLRPTRSDGYLRAGTVVAAGEEASFSGVIEEANCDGTVVDNGLNVINDNGLLGSPASCHGSLSSFGASDSGSYSSNGSDYGSGTSTASDGVSCSISISSDSGGRTLPRGDGSLANGIVCGSPSYADAYKRVPNRCATPCETLRSDSSISFEEGLEQAIENAKSPARTKSKIPLRRCSSLVIFPRSPSTTPPTSPTSLSPLPSRGPYQTSHQFLVSPGELAQSQDPTPPRGFLSTAVNGLRLSRTVCLPGEVRDIRPLYVRSSPREKNLSSVKTPKKTVREKSPEGRSSISVRFTQRRTYASRSEATNGHCRLEKPLEELKLNSGGKHPHLKLIRSTSACLPASQDADCRPDANGELGKPNSQASQNHHLLQRSISLEGSYQNVPCCLSSLKYNCSKVGTSQLHIQFARGNEGKVSNLQKESKRYCKRELCNNSRRSQRTRDDFLGQVDVPLYQLPTENPNLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTNGSEEENTEQAEELEPGWIILDQPDAACHLQQQQESSPLPPGWEERQDVLGRTYYVNHESRRTQWKRPTPQDSITEAESGNIQLQAQHAFTTRRQISDETEILENRESPESWDIITEDEATMYSHQNIQSPPTPSNFDIQSHLAEELNARLTTVGNTATSRQASSSHHSSRRDNVQTYTVEEQPALPVLLPTSSGLPPGWEEKQDDKGRSYYIDHNSRTTTWMKPAIQATLEAGQPSSSQSSSLSHQPQTAATDPSQHSLHQQPELQQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRRKTSLDPIDLGPLPPGWEERTHTDGRLFYINHNIKRTQWEDPRLQNVAITGPAVPYSRDYKRKYEFFRKKMKKQSDIPNRFEMKLRRTAILEDSYRRIIAVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLQWIIENDPTELDLRFTVDEELFGQTHQHELKADGSEIVVTNKNKKEYIHLVIQWRFVNRVQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYNVNHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQFFTVEQWGSPDKLPRAHTCFNRLDLPPYESFEDLWDKLHVAIENTQGFDGVD
| 65 |
A5D7P0
|
3.1.3.48
|
ACT_SITE 381; /evidence="ECO:0000250|UniProtKB:P30304"
|
MSAEFFSSKREEGSLASGPSFRSNQRKILNLLLERDASFSISSDLPTTPVEKKLFGDSANLSILSGGTPKRCLDLSNLSSGEMSATQLTASADLDETGHLESTGPEQVRLAGMNYRQHLIKCSPAQLFCSTPNALEHGRRKKDAICGSSANKENDNGNLVENEMKHLGSPITTVSKLHKNPELAEDQAEEISDELMEFSLEDQEKAKPPLNWSSLYRSSSLPDSLNSPSLKQVVKFKDSTIPDKLKKKYCSNQKELGKGLGLKKMVSLCDINMTQMLEEDSNQGPLIGDFSKVCALPTVSGKHQDLKYVNPETVAALLSGEFQGLIEKFYIIDCRYPYEYLGGHIQGALNLHSQEELYNFFLKKPIVPWDNQKRIVIVFHCEFSSERGPRMCRSLREEDRTLNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQDHKAELLRCRNQSKAWEGERQLQEQIALLVKDVSP
| 149 |
A0A7M7N573
|
2.7.11.1
|
ACT_SITE 211; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
|
MTSEYGKENSTQAHMSSKAHMTPVSVPRANAGPKRILKPNTTSSNVASSLNRGTTAQARTQPVKSAENGHGHDDKQMEPKKSWTLKDFDIGRPLGKGKFGSVYLAREKQTKYIVALKVLFKSQLQKAQVEHQLRREIEIQSHLRHPNILRLFGYFYDESRVYLILEYAPRGELYKQLQRAGRFDEQRTASYISQLADALKYCHSKKVIHRDIKPENLLLGLLGDLKIADFGWSVHAPSSRRNTLCGTMDYLPPEMIEGRMHDDKVDLWSLGVLCYEFLVGKPPFEAEGSTETYRRITKVHYQFPSYVSAGARDVIKRLLQHNPANRLPLEQVLAHPWIVENSKKKPSSSSTSSSESQS
| 99 |
A0A6I8N5K6
|
3.5.1.98
|
ACT_SITE 739; /evidence="ECO:0000256|PIRSR:PIRSR037911-1"
|
MHRPSLDGSEVSLGTRRHGPPGPAYETLRGTPPGPQAAPMDLRVGQRPPPPAEPPAVEPSTPEPALLALQHTQRLHHQLFLASLQPRRPEHIRLSLETPGPEVPAGQQEQELCHLLHKDKSKRSAVASVAVKQKLAEVILKKKQAALERTGHANGPGVPGPGIPYRTLEALESEGGSPSMLSGILPPVPSLPSDPPEHFPLRKTVSEPILKLRYKPKKALERRKNPLQRKESAPPSLRRRPTEPLGGESARQAQWGAGTPRGKSEASGRTDPCPVQSRFPPLPPTDSSPSSSSTPVSGCSSPNDSEHGPCPAPGHEVDGDRRTLPAVGPRVPVLGASHASLFLSQGLEPEASGALPSRLQPVLILEPSASHAPLLAVPGLGPVPFHFAHSLLSAERLPWPGPHRPLGRTRSEPLPPSSAARQQQQQQQQLLLGSQQPRNLERLKQHSPLGKWPAKPSEKPRLQQIPSAEDLEADGGDGRFGARDPERRELVLGRLEPEGPSEPLRHLGLNPQQQQQVFLREPQRVSGHPPRVAPGNTLLLSFAQGGHRPLTRAQSSPAAPASLPSTEASSKSGGLPGPETPARTTAFTTGLVYDSVMLKHQCSCGDNSNHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHAERHVLLYGTNPLTRLKLDNGKLAGILSQRMFVMLPCGGVGVDTDTIWNEMHSSNAARWAAGSVTDLAFKVAARELKNGFAVVRPPGHHADLSTAMGFCFFNSVAIAARQLQQKGKVGKILIVDWDVHHGNGTQQAFYQDPRVLYISLHRHDNGNFFPGSGAVDEVGAGSGEGFTVNVAWAGGLDPPMGDPEYLAAFRTVVMPIAREFSPDLVLVSAGFDAADGHPPPLGGYCVSAKCFGYMTQQLMSLAGGAVVLALEGGHDLTAICDASEACVAALLGSTVDPVSEETWRQTPNANATHALQAVIRVHSKEGEEGWAGGRGPRSEGGRVGGNPRFTPLLFPGKYWGSMKQLSSWPDPWDPEPPGTDSEEVEAVTALASLSVAVLAEKRPSEQLVEEEEEEPMNL
| 184 |
A0A3B3I7P3
|
3.1.4.11
|
ACT_SITE 330; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"; ACT_SITE 375; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"
|
MACVRRQSELSRSQELFQHARSQKVIQTNVKLLGLEGDPDLQFLLQGGDLLKVRSRSWKKTRFLQLQEDCKTMYRKSDKLFKSHQTFPIDDISSVRIGRQSEGLKKNTEEQLESRCFSIVFKSRRKNLDLVASSHEEAKQWVRGLEKLLSNVNNLSRQETREHWIFNCLKKADKDKDEKLNLSEVKRFLRLINIEMDDSYAEVLFQNCDKSKSGYLSGQEIKELYDLLSQRVEIDVIYQEYAKTTGFMSAHNLVEFLMKEQRERASLADAHSIIDKYEPDEQVKQKKLLSKDGFLMYMQCPEIMILNQEHKELYQDMQQPLSHYFISSSHNTYLLEDQLKGPSSTEAYIRALMKSCRCVELDCWDGSDDEPVIYHGYTLTSKILFKDAIQAIKEYAFKTSNYPVILSLENHCSVEQQAVMARHLSSMLGSALVTAPLGDGMPTNFPSPEELKGKFLIKGKRLNKLEANFTSEAAGDDTDVTEEEESSDETDEEQKKKSKLKLAKELSDMVIYCKSVHFNGFEDAQKNLSFYEMSSFKEGKAMKLAKESANAYIHHNVEKLSRVYPAGSRTDSSNYNPVPLWNAGCQIVALNFQTSCSEMDINQGRFLVNGKSGYILKPAFMRDPSSEFDPNTPTPGDWRQPKTLHVMVISAQQLPKVNQKKSSIVDPLVKVEIYGVPDDMAVKETTAIENNGFNPSWNESFQFGVSVPELALVRFVIEDYDSASSNEFVAQYTLPFTSLKMGYRNMPLLNRNGDLLPSAGLFVHIMVLNA
| 153 |
K7DCW7
|
1.8.1.4
|
ACT_SITE 516; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2"
|
MRREGRPWRSGGGAQRRWKYWRKGKYSGKMQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF
| 36 |
P77872
|
1.11.1.6
|
ACT_SITE 56; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"; ACT_SITE 129; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"
|
MVNKDVKQTTAFGAPVWDDNNVITAGPRGPVLLQSTWFLEKLAAFDRERIPERVVHAKGSGAYGTFTVTKDITKYTKAKIFSKVGKKTECFFRFSTVAGERGSADAVRDPRGFAMKYYTEEGNWDLVGNNTPVFFIRDAIKFPDFIHTQKRDPQTNLPNHDMVWDFWSNVPESLYQVTWVMSDRGIPKSFRHMDGFGSHTFSLINAKGERFWVKFHFHTMQGVKHLTNEEAAEVRKYDPDSNQRDLFNAIARGDFPKWKLSIQVMPEEDAKKYRFHPFDVTKIWYLQDYPLMEVGIVELNKNPENYFAEVEQAAFSPANVVPGIGYSPDRMLQGRLFSYGDTHRYRLGVNYPQIPVNKPRCPFHSSSRDGYMQNGYYGSLQNYTPSSLPGYKEDKSARDPKFNLAHIEKEFEVWNWDYRADDSDYYTQPGDYYRSLPADEKERLHDTIGESLAHVTHKEIVDKQLEHFKKADPKYAEGVKKALEKHQKMMKDMHGKDMHHTKKKK
| 13 |
Q9XF43
|
2.3.1.199
|
ACT_SITE 225; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 304; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 388; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 392; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 421; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 425; /evidence="ECO:0000250|UniProtKB:Q38860"
|
MPQAPMPEFSSSVKLKYVKLGYQYLVNHFLSFLLIPIMAIVAVELLRMGPEEILNVWNSLQFDLVQVLCSSFFVIFISTVYFMSKPRTIYLVDYSCYKPPVTCRVPFATFMEHSRLILKDKPKSVEFQMRILERSGLGEETCLPPAIHYIPPTPTMDAARSEAQMVIFEAMDDLFKKTGLKPKDVDILIVNCSLFSPTPSLSAMVINKYKLRSNIKSFNLSGMGCSAGLISVDLARDLLQVHPNSNAIIVSTEIITPNYYQGNERAMLLPNCLFRMGAAAIHMSNRRSDRWRAKYKLSHLVRTHRGADDKSFYCVYEQEDKEGHVGINLSKDLMAIAGEALKANITTIGPLVLPASEQLLFLTSLIGRKIFNPKWKPYIPDFKLAFEHFCIHAGGRAVIDELQKNLQLSGEHVEASRMTLHRFGNTSSSSLWYELSYIESKGRMRRGDRVWQIAFGSGFKCNSAVWKCNRTIKTPKDGPWSDCIDRYPVFIPEVVKL
| 56 |
A0A251TGE0
|
3.1.1.11
|
ACT_SITE 421; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MVTTFVSSPPNQAPPMHTLTSTLACVYKPLTLLIYFTIILTLNLQSMASTTTIFSILILLTYAATTATSQPPSSSSTVCQSTPYPSFCQTTLPINNSSATIYDYGRLSIRKSITAASKFANSIDKYLSNSPGLTTGTVRALQDCQYLAKLNLEYLSNAFATVNTTQTTLSDTKSEDIQTILSAILTNTETCIDGLQSNAASWTSKDGVVSPIKNDNKLYSVSLALVNKGWGSKKSKKNRVSHKHKGLEAISETVGRRKLLQVDGTGSQVVVSQDGSGNFTTITDAINFAPNNTSPSTAGYFVVYVTAGVYEEYVNIPKNKKNLMMIGDGINQTVITGNRSVVDGWTTFNSATFIVVAPNFVAMNLTIRNTAGAIKHQAVALRSGADLSTFYKCSFEGYQDTLYAHSLRQFYRECDVYGTVDFIFGNAATVLQNCNLYPRLPMSGQFNAITAQGRTDPGQNTGTSIQKCNIRAADDLAASNGTTVTYLGRPWKEYSRTVYMQSFMDSLIAPAGWSVWSGDFALNTSYYAEFNNSGPGSDTSQRVTWPGFHVINETDAVSFTVSGFIVGDAWLNQTGVPYDAGL
| 125 |
P0ABF6
|
3.5.4.5
|
ACT_SITE 104; /note="Proton donor"; /evidence="ECO:0000305|PubMed:8289286, ECO:0000305|PubMed:8634261, ECO:0000305|PubMed:9125497"
|
MHPRFQTAFAQLADNLQSALEPILADKYFPALLTGEQVSSLKSATGLDEDALAFALLPLAAACARTPLSNFNVGAIARGVSGTWYFGANMEFIGATMQQTVHAEQSAISHAWLSGEKALAAITVNYTPCGHCRQFMNELNSGLDLRIHLPGREAHALRDYLPDAFGPKDLEIKTLLMDEQDHGYALTGDALSQAAIAAANRSHMPYSKSPSGVALECKDGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQWDATSATLKALGCHSIDRVLLA
| 187 |
A0A8J1M3D0
|
3.1.1.4
|
ACT_SITE 92; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 141; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"
|
MLFVRVSSTLLVSSNTPKTYRPVNWFLIKWILVLSPALANTNTRNLWQFRNMIKCTIPTCDPYFDYNDYGCYCGIGGSGNPVDALDRCCQSHDNCYSNSKGPCNGILDSPYIEMYDYTCSGTSVTCSSKNNACEKFICECDRNAAICFSGAGYNLKYKNLDRSTNC
| 130 |
Q54DU9
|
3.1.3.48
|
ACT_SITE 75; /note="Proton donor"; /evidence="ECO:0000250"; ACT_SITE 107; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
|
MTGIRSALPNPASLVESSTHRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTYSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDSKETIGIHCVAGLGRAPVLVAIALIEGGMNPLQAVEYIRERRRGSINIKQIQYLKNYKSKKKSSCRIM
| 149 |
Q9RJS6
|
2.7.1.23
|
ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361"
|
MTIERVGLVVHGGREGAAEAAREVREWCDENAVACTDIDVWSDTGRHSAREEVDAAGDPDLVVTLGGDGTFLRGARLAAENDALILGVDLGRVGFLTEVPAPAVRSALDAVRDGGLEPESRMLLTLRASRLLEIPAEMEALLRYGRGPLLPPPRVRTDCESGDEWGIALNVTALNDVVLEKLSRDRQISVGVYIAGRLLASYSADALLVATPTGSTAYSFAAGGPVVSPRAEALVFTAVAPHMTFDRSVVTAPDEPVGLRILERSGRAAVSIDGQLRGVLDPGDWLGVYAAPRRLRAVRLGPMDFYGRLRERMRLTDAPAAVADGTPAPLWPVSTPPPGDLAHLALPVPGAEGASGDLLREQS
| 89 |
Q55848
|
2.7.6.1
|
ACT_SITE 214; /evidence="ECO:0000255|HAMAP-Rule:MF_00583"
|
MSAVSRIATLTRQSMLSALSDNNRLRLFSGSSNPSLSQEVARYLGMDIGPMLRKRFADGELYIQIQESIRGGDVYLIQPCCHPVNDNLMELLIMIDACRRASARQITAVLPYYGYARADRKTAGRESISAKLVANLITGAGAQRVLAMDLHSAQIQGYFDIPCDHMYGSPVIIDYLKSKQLTDLVVVSPDVGGVARARAFAKKLNDAPLAIIDKRRQSHNVAEVLNLIGDVDGKTAVLVDDMIDTAGTLSEGSRLLRAQGARQVYACATHAVFSEPAINRLSGGLFEEVIVTNTIPVPDDHHFPQLTILSVANLIGEAIWRIHEESSVSSMFR
| 114 |
W5N9Z9
|
2.7.10.1
|
ACT_SITE 784; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
|
MLTMGYTWVSLFTLMLLWFEKGWTEPVITPNLSYMVLLKGGSFTLQCRDNSSVKWSLERDVGYKKDLKSENKDGSYYLTISYAKPDVMGRYVCINEQTLAQSSVYIFVKDPPNLFQKTIMVDVISRVGDDPIIPCLVTDPDTKGLKLEKCSGEPVPKEMNTTASIEKGITINSVQKIFEGCYVCTAKYNGKDVKSDEYNLIVRLASSHAPDIKLDKNKKVILIKGETFEVKCSTVNVDHAFTLGWICPEAVDCTVKRETRKQIDNYSKDSQLLIHSVKVTDSGIYQCAAENKKGKTMTSVELQILERGFINISASENTTINVKAGESLTLTVEFEAYPRPENLYWMYEGEELQNASDHIIATEEDSYRYHSRLKLVRLRGSEGGNYTFFTSNSYAAVNQTFDVHVLSKPEIISQEGPINGQVRCVAAGYMAPEISWYSCKQPHVRCSDLPGATKETIEVSTITLPSSEFGKTEIASTLNISKLDFHTVECVAQIGNEQVYNLFSVNERIVQHELFTPLLTGFAAAAGGLCFILFILFYKYLQKPKYQIQWKVIEGINGNNYVYIDPSQLPYDQKWEFPRDKLRFGKTLGSGAFGKVVEATAYGMSKADTIMTVAVKMLKPRAHATEKEALMSELKVLSYLGHHMNIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRKRDMFFCSRLGDDSHYKNIQNKRGTENEESKNGYMTMRPSTAVPSLHSAPSEKRRLKRKGSYGDKDVSNDVLQEDTRSLDTEDLLSFSYQVAKGMNFLASKNCIHRDLAARNVLLTEGRVAKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFECVYTFESDVWSYGILLWEIFSLGSSPYPGMPVDSKFYKMIKEGYRMIGPEFAPNEMYEIMKACWDTDPLQRPSFAKIVEMIELQLSDSTKHIYLNFSSKFSNIEELHSHFWRLNSVGSSTASTQPLLVGEDVVFEDEQRHQRV
| 97 |
B6K069
|
4.6.1.16
|
ACT_SITE 196; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 204; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 235; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"
|
MPPYPIACLNGQYLLFDLEAVKEFRCKYGILGMLTGTLAQLPQQNVFLGLPVQLMNEEAYYLVKHGLAYLVDDVASHESTRAEITKYHVEQVHTQRRELAQEQHTENNRRQYEKKRLAMQKLGRPPPPEPSPAEDRRSDLLMVPVRTASNRELYAPQDSHIFPEVEMKRYHAFEYLLARKFCLNPGLRFGCHFVAYPGDSLRYHSHYLVNSYNWNEEVPVVNIIAGGRLGTGVKKAWLMCGTKSSSSKRNDTASTRCFSVEWAGFG
| 207 |
A0A9J7LDP4
|
2.1.1.37
|
ACT_SITE 1135; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016"
|
MLGSGVLQRQPLSETLKAKLAELEEDFSDGNVTEKGYIKKRALLLNGLMTPDDHKLILKLDQELKNKSLPEKEYITEVTKVLDKYTAGSISQDSMECETSETNCSSSEETGENSKTVEACSSEDSGVLTSSGDEEKAPETGVKKSPKNIKQEKGSDDGVSPPKRRKGKLNGKGQPTIMSMFSKVPQKRKATDSGPEVDSSTDEGNNSESKVEHEDKKIKHEDNDMDADANGPELRKKETTCSPQKPKAPPVKCKECRQLLDDPDLRMFPGDPQEAVDEVEMLTDERLSLLEEDQEYGTYDDRPQHKITNFSVYDKNTHLCAFDTGLIEKNVELYFSGAVKPIYDENPSADGGVLAKNVGPINEWWTAGFDGGENALIGFTTAFAEYIVMQPSEAYAPFMDTMWEKIHMSKLVIEFLVNNQEAAYEDLLNKIQTTVPPQSLRVTSFSEESLLRHAQFVVEQVENFDLAGDADEAPLLTTPCMRALIKLAGVTLGKRRAGRSGIKQPRKVKAKPMRQTKATTTNLVCSIFDTFFKDQIQDDKAGGPRRRRCGVCEVCQQADCGTCVACKDMTKFGGTGKSKQACVNRRCPNMAVQDADDDDDIEDDLDKEFSSTVGHKRTHFSPRKKVNSKVKISWEGKPIKEEGKKTFYSAVMLEEEKIETGDCVTVTSEDPTKPLFIARVMYMWEDSGGDMMCHVGWFCRGSDTVLGETSDPLEVFLVDECEDILIQFVKFKCKVILKTFDKDWFSHGGVEDPDSDYPIKEDDGRTFFCQKWYDPDLARFEDPPVLEEGSGHKFCPLCLRLDHSRKSEIPIVGEQLDDTMGDDNKVYYSLCQKGGLEYKIGDDVFLLPDSFSFSVKVKNSTKKASKKDNYDEDLYPEYYRKRGDYVKGSNEECPEPFRIGRIISIYCKRTVSGIINTHDVRLRVTKFYRPENTHKGKAGSHHTDLNMLYWSDEEAVVDFMSVQGKCQVVYGEDLDVSVEDWSSKGLHRFYFNEAYNTESKQFEEPPNKARSGGKKAKGKGKGKGKGKGKSSEAESKEQQPPSPAFTKLRMLDVFAGCGGLSEGFHQAGIADSKWAVEVMEPAAQAYRLNNPDCTVFTDDCNILLKLVMEGATTNSTGQRLPQKGDVELLCGGPPCQGFSGMNRFNSRQYSQFKNSLVVSFLSYCDFYRPKFFLLENVRNFVSFKSSMVLKLTLRCLIRMGYQCTFGVLQAGNYGVAQTRRRAIILAAAPGEKLPMYPEPQHVFSPRACQLSVMVDEKKYNSNTQWRQSAPYRTITIRDTMSDLPSIRNGHSATEISYDGEPRSYFQKIIRGNQYQPILRDHICKDMNALVEARMRHVPLAPGSDWRDLPNIVVRLSDGSSSKLLQYTHEDKKNGTSSTGALRGVCSCAEGTACDQNDRQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYRFYGSILDKHRQVGNAVPPPMAAAIGREIKKCLEDKAKKETQTGETKPVSMEA
| 47 |
A0A3B3H9Z3
|
2.7.10.2
|
ACT_SITE 332; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630220-1"
|
MCSSVLPHRLVPQKPDCLKDEAFTAAAFTPVAIQRIESSMRRFDKLKKSFPLLAHFHVYRRLGGSMQSEEGTEWLLELLMEVQLQQYFLRIQDDLNVTRLSHFDYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMCKRKSWMSKVFSGKRPDGGEFPQQSQPASSFRKLSPTPPLCLGEGVLSTQSGGGTTLDVQQKALTCLISEKDLTLFEKLGDGSFGVVKRGEWMTPSGKLNVAVKCLKTDVLSQPDALEDFICEVNAMHSLDHQNLIRLYGVVLTHPMKMVTELAPLGSLLGRLRCLQGPILISTLCQYAVQVACGMAYLEQRRFIHRDLAARNILLASAQRVKIGDFGLMRALPNNHEHYVMQEHRKVPFAWCAPESLKTRTFSHATDTWMFGVTLWEMFTYGQEPWLGLNGSQILHKIDKEGERLPKPEDCPQDIYNVMLQCWAQKPDDRPTFVSLREFLLETLPTDMCALQDFDEPDKLQIKVNEVITVIEGRAENYWWRGQNKCTLQVGQFPRNVVTSVAGLSARDISRPLKNSFIHTGHGDTNPHRCWGHRDKIDDLYLGNPMDPPDVLGLELNAARPTQLPGRAKKPYYDLVTEEEDLASAALKRLSLRKTGSLKGLRLIPTVWISASKQGDCRTSSSGQNPNSEVSLIDFGEELSPPTPSPSPVVEAPIPALAKLALEAENILDKTPPESPSTSLPRPLHPTPVVDWDAKPLPPPPAYDEVAQDEDDMEVSSINGSDQHLEEESICVHNPNEAPFSRLRLQGEGIFSKEVDMESVEDNLFLPSQGSRGTSTSFSQSAEIFLELQRECMRRLNAPKGTLCHLPASPNSQTQDGPLFSSSGEDKPQIPPRVPIPPRPIWRADQTCARWSRELSVSPTDNSEGVAGSDPGRPPQIPPRDPLSQPASRTPSPMGLVVGSPQQRLHSASPPTQQALLSSCAAAHAYSSYLSTSPGKLMPTTHSFASDPKYAAPKVIQVQGKDKGPCILPIVRDGRKVSSTHYYLLPERPPYLDRFGHFLREAEHLPTSATDDRHVRHANTATVRPMVVSAQTVQGHTQGQSLLQAEDLKANFSSNNNSSLGGPQSEVKTSVSLPRVCSDGVTTAVIPASCLRADSGGNGPDKVKVVQEAVHGVTLEECQAALQNQNWSVQKAVHFLKVEQLFCLGLKSRSDCLKLLETCDWNLEVASTRMLENYGSTTWQGR
| 98 |
B9REH3
|
3.2.1.21
|
ACT_SITE 416; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
|
MAAQVAILLCCLVMIGGFLGSTYATTPGHYTMPFNRSSYPSGFIFGAGSAAYQSEGAAYIDGKGPSIWDTFTREHPEKIWDQSNGDVAIDFYHRYKEDIQLMKRIGLDSFRFSISWSRVLPKGKVSGGVNPKGVKFYNDLINELIANGLTPFVTLFHWDLPQALEDEYNGFLSPKVVDDYRDYADFCFKTFGDRVKHWCTLNEPYSFSINGYNGGTFAPGRCSNYVGNCTAGDSSTEPYLVAHHLLLSHASAVRLYKAKYQATQKGQIGVTLVTNWFIPKSPASESDKKATMRIIDFMFGWFAHPITYGDYPEIMKAYVGDRLPKFTKEQSKLLKGSLDYMGVNYYTTNFASNNPVTTSNHSWSTDSQTTLSVTKAGVPIGTPTPLNWLYVYPRGIYHLMLHIRDNYKNPPIFVTENGLADANNASISIEESRKDALRIRYYHTHLTNLLQAIK
| 161 |
O35521
|
3.4.25.1
|
ACT_SITE 21; /note="Nucleophile"; /evidence="ECO:0000250"
|
MLRAGAPTAGSFRTEEVHTGTTIMAVEFDGGVVVGSDSRVSAGAAVVNRVFDKLSPLHQRIFCALSGSAADAQAIADMAAYQLELHGLELEEPPLVLAAANVVKNISYKYREDLLAHLIVAGWDQREGGQVYGTMGGMLIRQPFTIGGSGSSYIYGYVDAAYKPGMTPEECRRFTTNAITLAMNRDGSSGGVIYLVTITAAGVDHRVILGDELPKFYGE
| 180 |
A0A3B3HDF3
|
2.3.1.48
|
ACT_SITE 452; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
|
MPRRRQRAMAGSVSDGTEDSDSSAEREQTHSSESDGNMPKRQRLTRASTRLSQSSQDTPDLKRAADHDESPPLTPTGNAPSSESELDISSPNASHDESHTKDQASRDSDKDLSHRPKRRRCHETYNFNMKCPTPGCNSLGHLTGKHERHFAVSGCPLYHNLSADECKVKAISREKQEEEAKTQEENSSRHATRHQTPTPKQSKYKEQVAEMRKGRNAGQQKEQKEKHTEHRQTHGNTREPLLENITSEYDLELFRKAQARASEDLEKLRIQGQITEGNNMIKTIVFGRFELDTWYHSPYPEEYARLGRLYVCEFCLKYMKSQTILRRHMAKCVWKHPPGDEVYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLVGYFSKEKNSFLNYNVSCILTMPQYMRQGFGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYMCNFQGKEISIKEISQETAVNPVDIVSTLQSLQMLKYWKGKHLVLKRQVSRAGGGGGQKAEFYYNKRNWVPFSLKPGVPNMSKGSVGRSPAIENK
| 61 |
P39967
|
3.4.19.12
|
ACT_SITE 143; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 618; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"
|
MIKRWLSVNRKKSHPEKNTQGNDEINRKATSLKKTKGSGDPSIAKSPSAKSSTSSIPSNLASHERRSKFSSQTDNLAGNKHYHEHYHNMASTSDEREYDSSTTYEDRAFDTESSILFTTITDLMPYGDGSNKVFGYENFGNTCYCNSVLQCLYNIPEFRCNVLRYPERVAAVNRIRKSDLKGSKIRVFTNESFETSTNSGNSNTGYQSNDNEDAHNHHHLQQSDQDNSSSSTQEKQNNFERKRNSFMGFGKDKSNYKDSAKKDDNNEMERPQPVHTVVMASDTLTEKLHEGCKKIIVGRPLLKQSDSLSKASTTDCQANSHCQCDSQGSRITSVDDDVLVNPESCNDAVNNSNNNKENTFPTSEQRKKAALIRGPVLNVDHLLYPTEEATLYNGLKDIFESITENLSLTGIVSPTEFVKILKKENVLFNTMMQQDAHEFLNFLLNDFSEYIQRNNPRMRFGPQKTDNSNDNFITDLFKGTLTNRIKCLTCDNITSRDEPFLDFPIEVQGDEETDIQKMLKSYHQREMLNGVNKFYCNKCYGLQEAERMVGLKQLPHILSLHLKRFKYSEEQKSNIKLFNKILYPLTLDVSSTFNTSVYKKYELSGVVIHMGSGPQHGHYVCICRNEKFGWLLYDDETVESIKEETVLQFTGHPGDQTTAYVLFYKETQADKTENQNENIDTSSQDQMQTDNNIEQLIKCDDWLRDRKLRAAANIERKKTLGNIPEVKTAETKTPLNDKKRNKQKRKSRILSFIK
| 175 |
Q7XSK0
|
3.2.1.21
|
ACT_SITE 194; /note="Proton donor"; /evidence="ECO:0000269|PubMed:33471829, ECO:0007744|PDB:7D6B"; ACT_SITE 408; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:33471829, ECO:0007744|PDB:7D6B"
|
MAGGSKTRIHASLVSTLLLLLPLASAIHRSDFPASFLFGTATSSYQIEGAYLEGNKSLSNWDVFTHLPGNIKDGSNGDIADDHYHRYEEDVELMNSLGVNAYRFSISWSRILPKGRFGGVNPAGIDFYNKLIDSILLKGIQPFVTLTHYDIPQELEDRYGAWLNAEIQSDFGHFADVCFGAFGDRVKYWTTFNEPNVAVRHGYMLGTYPPSRCSPPFGHCARGGDSHAEPYVAAHNVILSHATAIEIYKRKYQSKQRGMIGMVLYSTWYEPLRDVPEDRLATERALAFETPWFLDPLVYGDYPPEMRQILGGRLPSFSPEDRRKLRYKLDFIGVNHYTTLYARDCMFSDCPQGQETQHALAAVTGESNGLPIGTPTAMPTFYVVPDGIEKMVKYFMRRYNNLPMFITENGYAQGGDSYTDAEDWIDDEDRIEYLEGYLTKLAKVIRDGADVRGYFAWSVVDNFEWLFGYTLRFGLYYIDYRTQERSPKLSALWYKEFLQNLHENQ
| 161 |
Q5B135
|
4.2.1.11
|
ACT_SITE 211; /note="Proton donor"; /evidence="ECO:0000250"; ACT_SITE 347; /note="Proton acceptor"; /evidence="ECO:0000250"
|
MPISKIHARSVYDSRGNPTVEVDVVTETGLHRAIVPSGASTGQHEAHELRDGDKSKWLGKGVLTAVKNVNETIGPAVIKENLDVKEQSKIDEFLNKLDGTPNKSNLGANAILGVSLAIAKAGAAEKGVPLYAHISDLAGTKKPYVLPVPFQNVLNGGSHAGGRLAFQEFMIVPDTASSFSEGLRQGAEVYHKLKALAKKKYGQSAGNVGDEGGVAPDIQTAEEALDLITEAIEQAGYTGKIHIAMDVASSEFYKPEEKKYDLDFKNPDSDPSKWLTYEQLADLYKSLAAKYPIVSIEDPFAEDDWEAWSYFYKTSDFQIVGDDLTVTNPLRIKKAIELKSCNALLLKVNQIGTLTESIQAAKDSYADGWGVMVSHRSGETEDVTIADISVGLRSGQIKTGAPARSERLAKLNQILRIEEELGENAVYAGQNFRKSVNL
| 200 |
A0A059DEL4
|
2.3.2.26
|
ACT_SITE 1528; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
|
MGSRGQKRTEVVEDFPADKRACSSLDFRPSSSSLPMENQVESTSSRLESHETDMDTASTASASSHSEGEPEKDSTCGSCDSDDVDPRYGGLREYHRSRSFGDHSKFKKILSSLTEETEPSGQLAVLTELCEVLSFCTEDSLSSMLADAFSPILVKLARHESNPDIMLLASRAITYLCDVFPRSSALLVRHDAVPAICQRLMAIEYLDVAEQCLQALEKISRDQPLACLEAGAIVAVLNFIEFFSTSVQRVALSVVANICKKLPSDCPSLFMDAVPSLCNLLQFEDQQLVESVAFCLTKITERVSQNPEKLDELCKHGMINQALRLINLNSGTTLSLPVYNGIIGMLVKLSSGSYLGFRTLYELNVCIILKDILATYDVPHGVSSPRLADGHGIQVQEVLKLLYELLPSLANNEDFQQVSEKGAFLCSNPGFLRMFGVDILPLLIQMVNSGANIRVCYGCIIIINNLLSLSTSDILAEVLTNSNFSSFLAGVFTRKDHHVLDIALQIAESSLRKLGDMCLKSFIKEGVFFAIDALITPEKCSHRLFPVFSGNQLSVDSSQKPANKGVLRCLCYAFENDHSPSASETRTCKLALDTIHQRAKDIKTSFFSPELCDSEEALTDILQMLKTLATSINDLMNKPVDESSLQHEEKFHSILHQIAVKLNGSEPISTFEFIESGVVKSLVNYLSNGLSTSDEVELDDKVGHLLVIEKRLRVFGRLVFTALDSLHGDLPMVILIRKLQSALSSLENFPVIINNSTKQRNSFAMVPNGRCVSHPCLRVHFVKGEGEESLCDYSQDVLTVDPFTPLNAIERFLYPKVKKSEHVEKNALVEQQNLPLKLPINANLTCGESSKHMEFHGMSTALQDLQQGEANLSKSIHDQPDVGQQSNPGETSDEQDCAVSQSKAPEPDINGSTQSPSSEDDNPSPKLLFYLDGQQIDRTLSLYQVFLQQQIKVGNETIASAKLWSQVFTLTYKRAAEPRQEYSQECPFSARNLPLLDKKGVHMQGIPCFSYLFAGKLVSNLEKPSPVYDIIVLLKSMEAMNRRAFQLMSMERMAAFAEGRMDNLDDLKFMAPLVLQNEFVSSKLTEKIEQQMRDSLAVSTGGMPSWCNQLMDSCPFLFSFEARRKYFHLSAFGQLQIQSDPSSHGSTGSSTDRRRSASSLVRKKFLVHRDRIMDSAIQMMDLYARQRVALEVEFDDEVGTGLGPTLEFYTLISHEFQKPGLGMWREDHGSFSSNKVMETHGSEMILSPFGLFPCPWAPALCTSENVEFAEVINRFILLGKLVAKALQDGRVLDLHLSKAFYKLIIGQDLTLYDIPSFDPELGRTLLEFQALVDRKRFLESVHGESSTLRNDLCFRNIAMEDLCLDFTVPGYTNYVLSSGPDHKMVNMTNLEDYVSFVVDATTNSGISRQVEAFKSGFNQVFPIKNLQIFSEDELERLLCGENNSWEFSELLEHVKFDHGYTASSTPVIYLLETIQEFDREQQRSFLQFVTGAPRLPSGGLASLNPKLTIVRKHCSKSADAELPSVMTCANYLKLPPYSSKEKMKEKILYAIREGQGSFHLS
| 65 |
A0A0D1CPG7
|
3.1.3.1
|
ACT_SITE 142; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
|
MDLDSKLPRPASAVDSSARRHRAQETSSQRYIRLRAAAYLSNVFKAALLLLTLLALHRESFDYVSDIASGVWHWPWSPRPVKTNIILMISDGYGPASLTFTRHFAQALNNDTDSESPFQLPLDTILVGTHRSRSSSSLITDSAAGATAFSCAKKSYNGAIGVTSDGNACGTVFEAAKRKGLLTGVVVTSRLTDATPAAFISHAASRAEEPLIASQMIGGNKNPLGQRTLDLAIGGGGCAFLPNSTIVSCRQDDEDTVEYAKQLGWDVRLAFPSNTSADSLYSQLHSSDELFGTASGRSKPQLPFMALLAPVNTPYEIDRVNIPAPLPLKPLSHYASKALELLSTSDQNDKGFILMIEGSQIDLCAHNNDPACHAREALAYHDTIALVKQFVDQHNSKSERTLLISTSDHETGGVTLGRQLSLDYPNYAYYPERLLNAKHSTPILTAVLIDFVRSETGKVASRDGKVSESLVRHFIRDKILGESGLGFSGKVQGGKPTEVEIEAVWKVVKDEILTVQDESTLYQASAYLRQSHNTAHRADGISRSLNWMGPVPGVNLDGIRRVISDIAARRAEIGFSTSGHTGIDINVYAYGAETHRLVGNQDNTNIGVVIKDILALDLEAVTRDLNKS
| 141 |
H3GA50
|
2.3.2.26
|
ACT_SITE 341; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
|
MAASALLVPAEREHLRLNVERASVFKDSMESLAIIPLQNARSVVRINFLDENGVDAGGLQREWFVMLNEALVDPVRGLFVCANKRDQTYYMSPCSDMELLPNQLLNLFAAGRLLGRALLEGSMLCFHLASPFLKLILGYPLSFEDLEDLDPEVYSNLRWLLENDNVDALDLDFTVTTKDGDSYRDIELVPGGSAIPVTDSNKREFVELKWQYLLVESVAPQLQVFLQGLYEIVPRELLLLFDPEEFDFLLCGSDEIDVDDWERNTKYSEDLHHHRSLKWFWELVREMPNEYRRRLLQFSTGSSRVPLGGFSALTSYDGRLCPFTLKAVSLIGDGFIHSHACFNRLDLPLHVVRDELKAVLYAVLETEVYGFTTD
| 65 |
Q7S2Z9
|
5.3.1.1
|
ACT_SITE 95; /note="Electrophile"; /evidence="ECO:0000250"; ACT_SITE 165; /note="Proton acceptor"; /evidence="ECO:0000250"
|
MARKFFVGGNFKMNGTRKDLKAIVDNLNNAQLDPNAEVVIAPPALYLDFVKQNLQKPNVEVAAQNVFNKPNGAFTGEISATQLLDLGVKWVILGHSERRNELGESDEFIASKTKYALDNGISVIWCCGESKDTRQAGETIKFVENQLAALAKEINDWKNVVIAYEPIWAIGTGLVATKEQAQEVHAAIRSWLKQNVSDKVAEETRILYGGSVNAKNCKDLAKEQDIDGFLVGGASLKPEFVDIINANL
| 213 |
A0A2K1WW45
|
3.1.1.11
|
ACT_SITE 411; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MSSSDNHNTLKNKKRLFLSLFSSILLVTAIVSIVAGVTSSKNSTESNNDHQVAHTILKSSCSSTLYPHLCFSALSAVPDATSKIKSKKDVIDLSLNRTMSATRHSYFKIQKLTSTRRSFTERENTALHDCLVMLNETLDQLSKAYQELQDYPSLKKSLSVHADDLKILLSAAMTNQETCLDGFSHDKADKKVRELFIDEEMHVYHMSSIALAIIKNVTDTDMAKEQSLSSGRKLEEENGTEWPEWLSAGDRRLLQATTVTPNVVVAADGSGNYRTVSEAVAAAPERSSSRYIIRIKAGVYRENVDVPRSKTNIMFMGDGRTTTIITASRNVVDGSTTFNSATVAAVGDGFLARDITFQNSAGPSKHQAVAIRVGSDLSAFYRCDMIAYQDTLYVHSLRQFYVSCIIIGSVDFIFGNAAVVFQDCDIHARRPNPGQKNMVTAQGRSDPNENTGIVIQKCRIGATQDLLAAKSSFRSYLGRPWKLYSRTIVMQTEISDIIDPAGWFEWDGDFALDTLVYREYQNTGPGANTANRVNWKGFKVVTSAIEVQPFIARNFIRGASWLPSTGFPYSFDL
| 125 |
A0A022RW71
|
3.1.1.11
|
ACT_SITE 401; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MAANKVAIFGLIATLAVAGAVAAAIILAGNTNTKTTKDQTNNISTSQKAIQDLCQSTYYQQTCTETLSNATNSSDPQTLIQTIFEIAISHLNNTIQQSGPLQQISNDPKTSQAYKTCTKVLDDSIQDLRKTIHRTETFDFFDFSIFIDDIKTWLTGALTYQETCLDSFEDTKGDHAETMRQLLKLSRELTTNGLAIANQIHRLFLPNLLAPPVAPTKHQLADRKPLSPRGDSNYYRKLLQMASDRRYDTPNVVVAKDGSGKYKTVTEALKEVPERSNETFVIHVKEGVYEEYVEITSGMWSVVLVGDGPTKTRITGKKSYGGDGLGTYFTATVGIDGDNFIGKDIGFENTAGAIGYQAVALRVSADKAIFYNCHIDGYQDTLYAHNHRQYYRDCTISGTIDFIFGNARALIQNCTLLVRKPLDNQACVVTANGRTLSNETSAFVIHGSRVVAAPEYPVDDKRIQSFLGRPWKEYSKTIFMASEIEGFISPEGWSPWDNTADHLDTCWYAEVGNRGPGADLTNRVKWPGIKNITMAEAAQFAPTMYMDSGHWIEGKGIPFDSVLEMVIKN
| 125 |
W1PQ18
|
3.1.3.48
|
ACT_SITE 47; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 49; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"
|
MAENLEPLEPEVKRIKREDNSMGTNVLLSDAQDAAAVNEKRTVFVWDMDETLILLKSLLDGTYGKSCDGAKDIEKGVEIGKCWEKHILQVCDEYFFYEQIEEFNEPFVDSLSEYDDGRDLSAYDFSKDGFSQPCDDANKRKLAYRYRVIAQKYAQGLHCVLDQETLKLWDDLYDLTDDFTDKWLSSARALLEQCLEGDFFSSSASFHSSSTTSSCHKKGEKVNVLVTSGSLVPSLVKCLLFRLNGSIPYDNVYSSWDVGKLQCFSWIKERFGSTASQFCVIGNGSEECEAAKAMGWPFVMIDLQPGCWHRFPGLSLKTIKQYIDVVYPEETKDES
| 149 |
A0A0P0VIP0
|
2.7.11.1
|
ACT_SITE 514; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
|
MPPRCRRLPLLFILLLAVRPLSAAAASSIAAAPASSYRRISWASNLTLLGSASLLPGAAGVALTTPSRDGVGAGRALFSEPVRLLLPQDAAASASASRAATPASFSTRFTFRITPSPTYGDGLAFLLTSSRTFLGASNGFLGLFPSSSASDEGELRDVSTVAVEIDTHLDVALHDPDGNHVALDAGSIFSVASAQPGVDLKAGVPITAWVEYRAPRRRLNVWLSYSPSRRPEKPALSADVDLSGLLRTYMYAGFSASNGNGAALHVVERWTFRTFGFPNSSYAPPPTKYIGPMPPNNQPLPPPPSPSPSPPPPSPPPPPHPNHRRRHLFYKVLGGVLGGMVLLGLVVVGSAVLLGRSVRRKNQEHAVASEDMGEATLSMEVARAATKGFDSGNVIGVGGSGATVYEGVLPSGSRVAVKRFQAIGSCTKAFDSELKAMLNCPHHPNLVPLAGWCRSKDELVLVYEFMPNGNLDSALHTLGGATLPWEARFRAVYGVASALAYLHDECENRIIHRDVKSSNVMLDAEFNARLGDFGLARTVSHGGLPLTTQPAGTLGYLAPEYVHTGVATERSDVYSFGVLALEVATGRRPAERGISVVNWVWTLWGRRRLVDAADRRLQGRFVADEMRRVLLVGLCCVHPDCRKRPGMRRVVSMLDGTAPLILVPDKMPPVLLQPVPNASSMNSADTANTAFFSCR
| 99 |
Q758T2
|
2.7.11.1
|
ACT_SITE 190; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
|
MSAWASQEAAKEEEAVGDFARMLERRDAGLLARVLSRAQTGPEAYVRGLWRAEVGLERWRLTRVLGCGSVACVFELGDGALALKVPTSRRKAPVLLHEVLIYSHLAQQAGGRLAERHVVPFHGVAAVTRREYRRLRGGEVVPALVLERMDTTLEAVHRRAAVSKGQWWRYARDLVAALQFLRESCVVHGDIKTANVLVRGQDAFLADFTSAAVCDAAPEPLTTTLEYCAPGLIGGGQPTHSTDVYAAGLCLLALITRFEPFRELSMMKSHSSAPTHSLHETQWLMNAISKGDPIKYNVLSQDLYDRWAEELHFLRRFFVPAAQDALSRWLAESNARVAEHAF
| 99 |
Q5KAN4
|
2.7.1.11
|
ACT_SITE 299; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184"
|
MSDSPAATPLPKDPEGITEQIQSVSTPPPPPQAQKPARQKKIAVLTSGGDSAGMNAAVRAIVRQSIARGCQAYIIREGWEGLVRGNTSGPTPAPTAPQSPTLSASSKTVTFSSLPPSQQFDKLTSTLNKESLANEVSFSDPNEVTPLEDTPLSFGYGQLLRDGAGEGDVEELASHGMQGLAIADREDEKGRSLKNKYIVRVGWDDVRGWQGEGGTLIGSSRCPAFRTREGRLQAASNLIHSGIDCLAVCGGDGSLTGADKLRGEWPSLVEELYTENKITDDQREAYHHLNIVGLVGSIDNDMALTDLTIGALTALHRICESIDSISSTASSHSRAFVIEVMGRHCGWLALLAGIATGADFIFIPEDPPKCEDWETEMCDLLQAHRKVGKRKSIVIVAEGALDRNLKPIKPDYVKKILVERLGLDTRVTTLGHTQRGGKPCAFDRILPTLQGVEAVQTLLSATPETPSYMIGIQENKITKIPLLEAVARTQMVAEAIENRDFAKAMSFRDSEFREMLQAFQISSSLDVSQNAPVDKRLRIGIIHVGAPAGGMNAATRQAVRFCHNRGHVPVAIYNGFEGLLDDNVSELSWLRVDSWTTRGGSELGTNRSLPSIDIGSVAAGFQRYSLDALLVIGGFEAFHSVVLLSQNRTNYPAFQIPIVHLPATLSNNVPLTDFSLGSDTSLNALVEACDAIKQSASASRNRVFVVETQGGMSGYIATMGALAVGAVLVYTPENGISLKLLQEDVEFLIKRYKLDEKGKSEGRLVIKAEKSSSVYTTETLTKIFKEEGKDLFDARSASLGHTLQGGVPSPLDRTRAARLSLRCMQFLEEHASPNSQASHHKPKSAAHPHAGAKSIAKDTAAMIAIIGSKVVYATMDDVLKVTDMKLRRGTDEWWSDCKELAETMGGRTGLMAKH
| 84 |
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