Datasets:
tamarpeleg
/
EC_exercise

Dataset card Data Studio Files
xet
Community
1
Entry
stringlengths
6
10
EC_number
stringclasses
260 values
Active_site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
Q6ZMQ8
2.7.11.1
ACT_SITE 253; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028"
MSSSFFNPSFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFKEFENAEGDEYAADLAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPGGGGVGPGPGAAGPMLGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYKWEAGRGAEAFPATLSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIRLEEAAPAAGHDPDCAGCAPSPPATADQDDDSDGSTAASLAMEPLLGHGPPVDVPWGRGDHYPRRSLARDPLCPSRSPSPSAGPLSLAEGGAEDADWGVAAFCPAFFEDPLGTSPLGSSGAPPLPLTGEDELEEVGARRAAQRGHWRSNVSANNNSGSRCPESWDPVSAGGHAEGCPSPKQTPRASPEPGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPAPCLVTPSWTETASSGGDHPQAEPKLATEAEGTTGPRLPLPSVPSPSQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKLASALNGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTPDSLDSLDIPSSASDGGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEAQEGCEPQAFAELASEGEGPGPETRLSTSLSGLNEKNPYRDSAYFSDLEAEAEATSGPEKKCGGDRAPGPELGLPSTGQPSEQVCLRPGVSGEAQGSGPGEVLPPLLQLEGSSPEPSTCPSGLVPEPPEPQGPAKVRPGPSPSCSQFFLLTPVPLRSEGNSSEFQGPPGLLSGPAPQKRMGGPGTPRAPLRLALPGLPAALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEEAPAVPVVVAESQSARNLRSLLKMPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAKESPPTFLRGSPGSPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPAAPAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAGAGGESKEA
99
A0CA73
2.7.1.21
ACT_SITE 85; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR035805-1"
MFTGTISVIYGPMFSGKTSELMRLVKRFTISERKCAVLNYANDNRYSDDQCISSHDKQYLKAIKVTKLFDAFEKCKDYDVVAIDEGQFFCDIVEFSEAMANLGKIVIVAALDGTFDRKPFRNILSLIPLAERITKLTAVCWFCKKENASFTKRTVQSQEIELIGGEDCYKPACRACFNLTEDKFEKHTLSQIPVYSNDERLFGQQNLIC
88
Q1LX51
2.7.10.2
ACT_SITE 315; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MKWSEMASVNATQQHLNFSSSWEEDSSDNSFDEWTHKSVPLRSPCRTPRIQRHRNRSITVSPSVPTSPIPYAAWKKLRLCDSPSTPKSLLSKSTMPCSSSKTCRSQRFLRLSTAFERVPSVNINPFTPDTVRRNSEHYKRKSQRSDDDEDYGPRSKEIQNSSEDESFFLPSKRPAVSARMLSRYESEFLELACIGVGEFGSVYRCVKRLDGCMYAIKRSRRPIAGSANEQLALKEVYAHAVLGHHPHVVRYYSAWAEDDHMIIQNEYCDGGSLHDAITEKREQGEFFSVPELRDLLLQVSMGLKYIHNSGLVHLDIKPSNIFICRRSTLSAGGEGDSEEEDESHSSGVVYKIGDLGHVTSISSPQVEEGDSRFLAYEVLREDYTHLPKADIFALGLTVLLAAGASPLPQNGDDWHRLRQGELPNLPHELPALFKDLLKSLLDPDPTARPSATALCRHDVLCKERAGKLATQLRKELNVEKFRTAMLERELKEARLAATSPQQSCQPGSLPKAKRKLVGRNVARSVSFGFPGY
98
G7ICT5
1.11.1.7
ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MVKMHAILSIATLVIVILSVSTTLASSTSLKYGFYKTTCPSAEAIVRRAVNKAVSLNPGITAGLIRMHFHDCFVRGCDGSVLLDSIPGIRSERDHPANNPSLRGFEVINEAKAQIEAACPKTVSCADILAFAARDSARKVSGGRIDYSVPSGRRDGRVSIFDEVTQNLPPPTFSAEQLIDNFDRKGLSVDEMVTLSGAHSIGVSHCSSFSKRLYSFNATFPQDPSMDPDFARLLRSKCPPPQSQQSQSQIQNLDSTVAFDGSTPNDLDNMYYKRLKNNRGLLTSDQILVNSGLTKRMVLKNARHAAIWNVKFAKAMVHMGNLDVLTGSQGEIREYCSVVNFI
14
A0A1U8JHV1
3.1.1.11
ACT_SITE 385; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MANIRQPLLDRPRGSYSRDCPLIFTLVLLICLAALVAIPLVRFSSFDANHPYKYCERAVDQKSCSALLSEVASKTTVRTKGVDLLHAFLERSASDIQNVINQARNFNDGINNRREQASSADCLELMELSRDRIMDSMVGVEKQDVNWHSNAQAWLSSVLTNHVTCLDGLQGSVRTLMEPGLSDLISKARTSLAILVSVSPTKTEFDDDPLTGGFPSWLSSKDRKLLQALPNEIKADVVVAKDGSGNYKTLGEAVATAPDKSKTRYIIHVKKGTYKENVEIGANKKNLMIVGDGMNSTIITGSLNVIDGSTTFKSATVAAVGDGFMAQDIWFQNTAGPQKHQAVAIRVGADQSVINRCKIDAYQDTLYAHSNRQFYRDSYVTGTVDFIFGNAAVVFQNCKLVARKPMNSQSNMVTAQGRLDPNQNTGTSIQNCNILASADLEPVKGSIKSYLGRPWKEYSRTVVMQSYIGDHIDPSGWSVWSEDFALKTLYYGEYMNRGPEADTSKRVKWPGFHVITSAEEAKKFTVAELIQGGSWLKSTGVTFKEWL
125
H2MIE3
2.7.10.1
ACT_SITE 820; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
MERHQPARGANRELAGFQAAHMAAKLWRTLSASIWILTLASSSRTRIYPPNEVTLLDTRTVPGELKWAARPSEGGWEEVSIMDEKNIPIRTYQVCNVLGPNQNNWLRTDWIPRSGAQRVYVEVKFTLRDCNSLPGVTGTCKETFNLYYHESNEDRESYIKESSFIKVDTVAADESFTQVDVGDRIMKLNTEVRDVKVTNRKGFYLAFQDVGACIALVSVRVFYKTCPLTIRNLATFPDTVTGADTSSLVEVRGSCVNQSEEREEPKMYCGADGEWLVPIGGCLCNPGYEEKGGSCQACSAGFYKAKSSDIGCSKCPPHSHSLRDGANVCDCHSGFFRADADPPSMACTQPPSAPQQLISVVNETSVVLEWTPPRRLGGRSDIGYNVECLICQTGQSERRPVERNRTVPQPVAQQHGVGMQSDQGIVGPEVPLGRGVFQRPGSSSTPISSCLPCTPDVHFSPSQTDLLTTKVVVSELRAHTHYTFIVYARNGVSQASGSGAAQSASVSVTTNQAAPSPVSSIQVTDVTRHSLSLLWQQPDRPNGVILEYEVKFYEKDQRERSYRIIRTFLQSVDVTGLKPLTVYVFHVRARTAAGYGEYSSPFEFSTNSDPFPLIGEGVNSAFLLLSISGVGLLVLISAVVFFISRRRSKYSKTKQDSEEEKHLNPGVKIYVDPFTYEDPDQAVHEFAKEIDVSSIHIEKVIGMGEFGEVCSGRLRVQGKRETYVAIKSLKAGYSDKQRRDFMSEASIMGQFDHPNIIRLEGVVTRCKPLMIITEYMENGSLDAYLRKHDGQFTVIQLIGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTREATGSYLSPGGKIPIRWTAPEAIAYRKFTTASDVWSYGIVMWEVVSYGERPYWDMNNQDVIKAIEEGYRLPAPMDCPVVLHQLMLDCWERERAERPTFSQILNMLDKLIRNPGTLRRTGGDRSPGTLIESGVGSEVCVSVIPELCLPQWTLCEWLQSIGLERYRDTLAAAGYTSLDSLLALTHQEMDRLGIITPSHQDMLIASVQQELLSRMQHMQHSMVPV
97
A0A2G2YHJ2
1.11.1.24
ACT_SITE 46; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
MPGLTIGDDLPNLEVETTNGKMKLHDYVGDSYTILFSHPGDFTPVCTTELGMMAAYANKFAERGVKLLGLSCDDVHSHKEWIKDIEAYNKGHKVTYPIIADSKRELIKQLNMVDPEETDSSGHKLPSRALHIVGPDKKKAAKHKIATPANWKPGEPVVISPNVSTEQAKEMFPQGFDTANLPSGKSYLRFTNV
12
I1JFF0
1.11.1.7
ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKINILLCVVLLGFLGVCQGGSLRKKFYKDSCSQAEDIIKSKTQQHVSANPDLPAKLLRMHFHDCFVRGCDASVLLNSTANNTAERDAIPNLSLAGFDVIDDIKSELEAKCPKTVSCADILALAARDAVSVQFNKSMWEVLTGRRDGTVSNSNEALANIPAPFFNFTQLKQNFASKGLTLHDLVVLSGAHTIGIGHCNLFSNRLYNFTGKGDQDPSLNSTYAEFLKTKCQSLSDTTTTVEMDPGSSTNFDSDYYPNLLQNKGLFQSDAALLTEEQSEDIAKELVDQDKFFTEFAQSMKRMGAIDVLTDSAGEIRNKCSVVNS
14
A0A1Y1IRA0
1.11.1.6
ACT_SITE 57; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 130; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
MGSYRGPILTNGAGHPVSDDNNSVTIGETGSILLEDFHLLDKLAHFDRERIPERVVHAKGAGAHGYFEVTHDVSDICKAKFLDRVGKRTRCFTRFSTVGGESGSADTARDPRGFAVKFYTEEGIYDLVGNNTPVFFIRDPLKFPDFIHTQKRNPETHLKDPDMFWDFLSLVPESVHQVMILFSPRGTPDGYRFMNGYGSHTFKWVNDHGKAHWVKIHYKTDQGIKNLTTEQADHLAGSDPDYATRDLSNAIKRGEYPSWTFYVQAMPLEDAERFDWDPFDLTKVWPHKQYPLRQFGRMVLNRNPANYFAEVEQAAFSPAHMVPGIEPSPDRMLQGRLFSYDDTHRHRLGPNYLQIPINRPINPQSNHQRDGLMTVNENGGAMPNYFPNSVEGTPAPQPQRPDVHMYQSKGGAIGRKVFKKWQEQDDYSQPGALFRLMPKNEQDQLIANLAGHMSAAKEHIRRREIEVFRRCDAELGRRLDQAIADKVRGASHVSVNAGNFAVANL
13
A0A452DII9
2.1.1.37
ACT_SITE 1333; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016"
MNECLRQGSQQMEELGQIHCSAQGCAPPSRMRDPCAEPVPLPPPTHGTASLCVVRPDFPHAWAGMVRAASARGPSPSVSARKARVACAAAASAAPSKMPARTAPARVPALASRAFSLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLRTEIKNQLCDLETKLHKEELSEEGYLAKVKSLLNKDLSLENGAHAFSREANGCLENGSQTSGEDCRVVMAEKGKPPKPVSRLYTPRRSKSDGETKSEVSSSPRITRKTTRQTTITSHFPRGPAKRKPEEEPEKVKSDDSVDEEKDQEEKRRRVTSRERVAGLLPAEEPGRVRPGTHMEEEGRDDKEEKRLRSQTKEPTPKHKAKEEPDRDVRPGGAQAEMNEGEDKDEKRHRSQPKDLASKRRPEEKEPERVKPQVSDEKDEDEKFWRIQFTYQSTSREEKRRRTTYRELTEKKMTRTKIAVVSKTNPPKCTECLQYLDDPELRYEQHPPDAVEEIQILTNERLSIFDANESGFESYEDLPQHKLTCFSVYCKRGHLCPIDTGLIEKDVELLFSGSAKPIYEDDPSPEGGINGKNFGPINEWWIAGFDGGEKALLGFSTSFAEYILMDPSPEYAPLFSVMQEKIYISKIVVEFLQSNPDSTYEDLINKIETTVPPCMLNLNRFTEDSLLRHAQFVVEQVESYDRAGDSDEQPIFLSPCMRDLIKLAGVTLGKRRAERRQTIRQPAKEKDKGPTKATTTKLVYQIFDTFFAEQIEKDDKEDKENAFKRRRCGVCEICQQPECGKCKACKDMVKFGGSGRSKQACQKRRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKKKKQNKNRISWVGDAVKTDGKKSYYKKVCIDSETLEVGDCVSVIPDDSSKPLYLARVTALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVQVIYKAPSENWAMEGGVDPEALMSEDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKYKFCASCARLAEMRQKEIPRVVEQLQDLEGRVLYSLATKNGVQYRVGDGVYLPPEAFTFNIKLSSPVKRPRKEPVDEALYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCSKKSNGRPNETDIKIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPQCLQDFSAGGPDRFYFLEAYNAKSKSFEDPPNHARSTGNKGKGKGKGKNRTKSQTCEPSELETEIKLPKLRTLDVFSGCGGLSEGFHQAGISETLWAIEMWDPAAQAFRLNNPGSTVFTEDCNVLLKLVMAGEVTNSRGQKLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRYFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEPLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEIRNGASALEISYNGEPQSWFQRQLRGSQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTLARKLRYNYHDKKNGCSSSGALRGVCSCVEGKPCEPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKRCMLAKARESASAKIKEEAAKD
47
P83102
2.7.12.1
ACT_SITE 402; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MVGSQEKKNNHIELSETPATDKNNLNTTHLENTQLSKALSPPTSLPQIQIQMINQNLTHTGIAQNNTEKANRHQYRDSGLQYLTRCFEPLAMLNDSKEDFPTQPSNNIANYPGDIQILPIFDCCEISESIQAISLPNVTSPSKTKDVPGLFLRTISENSKSKSEPECESLISVKESSVMENHTFLFHEQIIMSGQQKCELHEKPKVLVVSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYGPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAETTASSTSATSISLTIKRENSHSSLRLHHGAVPETDFKLIKSVPEGSSTATKEPMMNSDILPESFRQTTVVSPSKHSADSGGMSCLSAVDVGPSRYYPYMNNNENNRLFSSSLNSSANSLSHLEQATKLDALGEYSASTTPNLLSKNTGYSFNSGSINIDVAQESLVNIASNYALDKSIDIIGKSNVSLHTNKLKVQSKDM
107
Q06098
2.7.11.1
ACT_SITE 280; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MNSTPPTSPVTRVSDGSFPSISNNSKGFAYRQPQKHKSNFAYSHLVSPVEEPTAKFSEAFQTDYSSKAPVATSEAHLKNDLDVLFTTPRFYSPENLALMFRLSNTVSSLEFLDEFLMGILLAPEMDFLSNPSYSLPSNKLVGQGSYSYVYPISSSASSRCNNDSGVVLKFAKSQHKSKVILQEALTLAYLQYMSPSTNESHIIPFYGLTYITKSHFRRLRSNECVPGLILPKCEMSLYHFNTAVSHKLSLITKRKIWWRLMKQMIDALKSLKTNGIIHGDIKTANILITEMHVLNGGHCKDFDFYLADFTSAFHINQTPTDLNTTVEYCAPELIDSSSDHVPTFESDLYAVGLCLLSFISQHEPYNELQALVSHGSSPGIGSSSIQQSQWLINALLKKDPINLNMLRNDLFQDWKSELALLSRILVDRLPLENLITILDSNYI
99
Q54UF3
4.1.1.17
ACT_SITE 402; /note="Proton donor; shared with dimeric partner"; /evidence="ECO:0000250|UniProtKB:P11926"
MTGTKRNGEEVVNENNNNNVAEETNKKAKVDESSTETTESTSCSLLSRCEKLDIVRKELDVKPWDQGKVTIQELITSLLDKTDRDAFFVADVGVIIKQWQKWVKNLPNVKPYYAVKCNPTVGVLRVLDALGTNYDCASRTEIESVLNLGVDPSRIIYANPCKQISALKFARAHNVKLMTFDNLSELEKIEKFFPEAELVLRIAPDDSKSVMRFGSKFGVHIDDCNDLLEMAKEMNLKVVGVSFHVGSGCQSGDSYADALIMVKSVFDMAKKLNMELTLVDVGGGFTGSDDEKFNAFTKVIREKTAELFSPNVKIIAEPGRYFAAQSHTLAVTVISKRSIKQEDNRQHPRRTSNNMRQYNYYLADGVYGSFNNTKFDYAKVEPLLLKPSTKQPTPCTLFGPTCDSIDVVLKDTQIPELKIGDWLYFQDMGAYTIASSSSFNGFCPPPVYYYNSIPEEELKNL
195
A0A1S4H1N3
4.1.1.50
ACT_SITE 81; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 95; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 285; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 299; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MAESEDLSNSSSNSSSREDMHFFEGVEKLLEIWFEPSTACKNADLRKIPRPMWDALLKTVRCEIISFTRNDQIDAYVLSESSMFVSKRRWILKTCGTTTPLQCFEPLLRLAAEIAGYTEIEDLFYSRKNYKRPELQVSPHRGFDEEVAFLDSFFDDGRAYSLGAINRDCWHLYTLSRGGGGSKILKRNNHLHQLMEQHHSQQLQQQQQEDDDVQQLDAQLIEASMQPDPDQTIEILMTDLDPSVMAIFTKDVCTTAKEATQKSGIHRLLPGMVIDDYLFDPCGYSMNGISKNGCYMTIHITPEREFSYVSFESNVASSDYGELIKRVTRTFQPGKFIVTVFANKTSIAANANREIEHLGTIDQWKRRDIQYSRFASYDLTYAQYCKYPS
196
W5N3C2
2.7.10.1
ACT_SITE 722; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
MNEPRPSRPVLQPGFPGNSTVVAGSDVELHCRVSGTARARIQWFRPVERDGSVSVPGGPPYLRALTPNRLNVSKGSSLRLANVSLADAGEYVCVAESSAGRDQRSAWLTVLTDLILFECEQMKRTELKGHAWENTRISKDETTEQFFLEPGEVLKLTCDANRTGGIHWFKGDMRIHHGDRIQIQANTMEISEVTYEDSGPYLCVTRGTREVLRNFTITVVDSLESGDDDEDNGLEDTMADVDEEQTYYTRGPYWTHTQRMEKKLYAVPAGNTVKFRCPAMGSPLPTIRWLKNGREFRGEHRIGGIKLRHQHWSLVMESVVPSDRGNYTCVVENIYGSISHSYLLDVLGKGRGPHSSSCPGGETIYSHCVVCPVHFYFECTVYKNVHMLPKTSEHFNSGPATHSPNGTIPWQLLKTGSLNMSEVEVLYLPNVTMEDAGEYTCLAGNSIGFSFQSAWLTVLPAEEEILEEVDLLETKYTDIIVYASGSLALVMAVVIVVLCRMQSSSGVEPFDVLPVQKLSKFPLRRQYSVESNSSGKSSASLMRVARLSSSCTPMLAGVMEFELPLDPHWEFPRENLTLGKPLGEGCFGQVVRAEAYGISKESPDQVATVAVKMLKADDATDKDLADLISEMEMMKMMDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRPPGMDYTFDVTKVPEEQLTFKDLLSCAYQVARGMDYLASQHCIHRDLAARNVLVTEDKVMKIADFGLARGVHQIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPSNCTHELYMLMRECWHAVPTQRPTFKQLVQDLDRILLSVSDEYLDLSTPFEQYSPSCEDASSTCSSDNDSVFTHDALSTDPCLLGYHDVHSRLQMKSAIA
97
B5YHC8
3.4.21.89
ACT_SITE 37; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 92; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
MTGKKILEYVKSIGIAILIALFIRAYIVQAFKIPSGSMIPTLLIGDHLLVNKFIYGVNPPLSDEKILVFETPKRGDIIVFKYPEDPSRDFIKRVIGVEGDTVEIKNKKVFVNGIELKEPYARHTDSYIHPRELDPRDNFGPIKVPPHKLFVMGDNRDQSYDSRFWGFVDLKDVKGKAFIIYWSWDNDNHKPRLQRIGKLIK
178
A0A804JXS0
3.2.1.1
ACT_SITE 200; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 225; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"
MKPLLLAFVFLVVLSLTTAQSQILFQGFNWESWRKQGGWYNFLRSQVPDIARAGVTHVWLPPPSHSVSEQGYMPGRLYDLNASKYGTRDELKSLIAAFHDKGIKCVADIVINHRCAERKDARGIYCIFEGGTSDSRLDWGPHMICSDDTQYSDGTGNRDTGGDFGAAPDIDHLNQQVQQELTDWLNWLRTDIGFDGWRLDFARGYSPSIAKIYVSHTSPDFVVAELWSSLTYGGDGKPAYDQDGSRQELVNWVHDVGGPAAAFDFTTKGVLQAAVQGELWRLRDPQGKASGMIGWWPEKAVTFVDNHDTGSTQKLWPFPSDKVMQGYAYILTHPGVPTIFYDHLFDWGLKDEITGLAAIRTRNGILPGSTLRILVADADLYLAVIDEKVMVKIGQRYDVGNLVPANFHVVASGNGYCIWEKR
157
P64180
1.2.1.12
ACT_SITE 153; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q6GIL8"
MSTNIAINGMGRIGRMVLRIALQNKNLNVVAINASYPPETIAHLINYDTTHGKYNLKVEPIENGLQVGDHKIKLVADRNPENLPWKELDIDIAIDATGKFNHGDKAIAHIKAGAKKVLLTGPSKGGHVQMVVKGVNDNQLDIEAFDIFSNASCTTNCIGPVAKVLNNQFGIVNGLMTTVHAITNDQKNIDNPHKDLRRARSCNESIIPTSTGAAKALKEVLPELEGKLHGMALRVPTKNVSLVDLVVDLEKEVTAEEVNQAFENAGLEGIIEVEHQPLVSVDFNTNPNSAIIDAKSTMVMSGNKVKVIAWYDNEWGYSNRVVDVAEQIGALLTSKETVSAS
22
A0A072TVL2
5.3.1.8
ACT_SITE 298; /evidence="ECO:0000256|PIRSR:PIRSR001480-1"
MEDSNPNNSLQKLHCSVKNYDWGLPGQLSQVAKLSELNSGFKFDPMKPYAELWIGTHDSGPSFLVSDDDGQRISLKDWIFDNPDLLLGHKVVKKWGSDLPFLFKVLSVGKALSIQAHPDKELARMLHKLHPDVYKDGNHKPEMALAMTDFEALCGFITLKELKAVIHTVPEVVNLVGASNANLVLETSDQNEEKVKPVLQAVFTHLMSASKEIVTDAVNRLINRLHEESEMRHLTEKELLVLRLENQYPSDIGVIAAFFLNHVKLNPGEALFLGANEPHAYLSGECIECMATSDNVVRAGLTPKFIDVPTLCSMLTYKQGFPEILRGVSMNPYVNKYIPPFEEFEIDRCILPKGQTVVFPAVPGPSIFLVTAGEGSMNTGSPKVYEITEGDALFAPAYTEISVASESELHLYRTGINSKFFEDS
214
P36004
2.7.11.1
ACT_SITE 563; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MVMQEEKKRQQPVTRRVRSFSESFKNLFRPPRSRDSSPINVTRIPYRSSSTSPKRSSEPPRRSTVSAQILDPKNSPIRQRSYTLKCCTPGLSHPFRQTGSGASNSPTRHRSISGEEQEIVNSLPEYKRSASHTFHGIRRPRSRSSSVSSCDSSNGTTSSSDSQWAMDSLLDDSDNDLTPYRGSNKDILKSKDRAPYNYIDDYNKKALRRATSYPNPLPSKQFYNERLYTRRSHPDEESLESLPRFAGADVQCIIEQNGFKVYEDGSHEHNIKLSGVIAKLEKGNSLPAHRQGSLSRPRLGITLSGLFKHHKNECDIENALSLLPNVEKSQTNHEKRTGQSPNDSNRSSPTQGREDYLKIVNPDASLGSDELKLINSLSSRIHKSLQNYLQEKNLKPAECIGEQAPTFQDNYGHPVGLVGAGAYGEVKLCARLRNEKDSPPFETYHDSKYIYYAVKELKPKPDSDLEKFCTKITSEFIIGHSLSHYHKNGKKPAPNILNVFDILEDSSSFIEVMEFCPAGDLYGMLVGKSKLKGRLHPLEADCFMKQLLHGVKFMHDHGIAHCDLKPENILFYPHGLLKICDFGTSSVFQTAWERRVHAQKGIIGSEPYVAPEEFVDGEYYDPRLIDCWSCGVVYITMILGHYLWKVASREKDMSYDEFYKEMQRKNQFRVFEELKHVNSELATNRKIALYRIFQWEPRKRISVGKLLDMQWMKSTNCCLIYDST
99
Q8NFD2
2.7.11.1
ACT_SITE 145; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPLGIVMEFMANGSLEKVLSTHSLCWKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIIIRVAAGMRPSLQPVSDQWPSEAQQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQSRVAVPESKALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGSKPGAEMEI
99
Q9BGI1
1.11.1.24
ACT_SITE 105; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000250|UniProtKB:P30044"
MRLGWLRVLGCRPGSVVSRATIVEGASTTAAGTRGCLEGILEWTFGGVRGFRSAAVAMAPIKVGDAIPSVEVFEKEPGNKVNLAELFKGKKGVLFGLPGAFTPGCSKTHLPGFVEQADALKAKGIQVVACLTVNDVFVTEEWARAHKAEGKVRLLADPSGTFGKETDLLLDDSLLFLFGNHRLKRFSMVIEDGIVKSLNVEPDGTGLTCSLAPNILSQL
12
C5YZJ3
1.11.1.7
ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MSRSTWLAFAWAAALVVVVVAASTTTTAHASHHASLEVGFYKHSCPEAESIVRDAVRRGVARDAGVGAGLIRMQFHDCFVRGCDASILINSTPGNKAEKDSVANNPSMRGFDVVDDAKAVLEAHCPRTVSCADIVAFAARDGAYLAGGLDYKVPSGRRDGRVSREDEVLDSNVPAPFDDVAELIQSFKRKGLTADDMVTLSGAHTIGRSHCSSFTQRLYNFSGQLGRTDPSLDVAYADHLKMRCPWPSSDGKRHPAVVPQDPVTPATFDNQYFKNVVAHKGLFVSDKTLLDSTCTAGIVHFNAAVDKAWQVKFAKAMVKMGKIQVLTGDEGEIREKCFVVNPH
14
Q8REF0
3.5.1.88
ACT_SITE 134; /evidence="ECO:0000255|HAMAP-Rule:MF_00163"
MVYKIKKYGEDVLKQIAKEVELSEINDEFRQFLDDMVETMYETDGVGLAAPQIGVSKRIFVCDDGNGVLRKVINPIIVPLTEETQEFEEGCLSVPGIYKKVERPKRVLLKYLNEYGKEVEEIAENFLAVVVQHENDHLDGILFIEKISPMAKRLIAKKLANIKKETKRIKEENE
183
Q942L2
5.3.4.1
ACT_SITE 64; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 67; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 183; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 186; /note="Nucleophile"; /evidence="ECO:0000250"
MAIPRISPRKTLPLFAALALALAWAFAAPAFADGDDVVALTESTFEKEVGQDRGALVEFYAPWCGHCKKLAPEYEKLGASFKKAKSVFIAKVDCDEHKSVCSKYGVSGYPTIQWFPKGSLEPKKYEGQRSAEALAEFVNTEGGTNVKLATIPSSVVVLGPDNFDSIVLDENKDILVEFYAPWCGHCKHLAPIYEKLASVYKLDDGVVIANLDADKHKDLAEKYGVSGYPTLKFFPKGNKAGEDYDGGRELDDFVKFINEKCGTSRDTKGQLTSEAGRIASLDALAKEFLGAANDKRKEILSNMEEEVVKLSGSAAKHGKVYIAIAKKILDKGHDYTKKETERLERMLEKSISPSKADEFIIKKNVLSTFSS
215
M5VVU6
3.2.1.1
ACT_SITE 202; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 227; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"
MKSLTTLFCVLLCINLLPNFAASQILFQGFNWESWKTEGGWYNSLRKSVPELASSGITHVWLPPPSQAASSEGYLPGRLYDLSASKYGSQDELKSLISAFHDSGIQAVADIVINHRTAEKQDERGIWCIFEGGTPDNRLDWGPSLICSDDTQYSDGKGNPDTGAGYDAAPDIDHKNTRVQKELSDWMNWLKTEIGFSGWRFDFVRGYSPEITKLYMTNTSPNFAVGELWNSLAIGSDGKPEYNQDAHRQELAGWVEGAGGAVTAFDFTTKGILQAAVQGELSRLKDPNGRAPGMIGLLPGKSVTFIDNHDTGSTQKIWPFPSDKVIQGYAYILTHPGIPSIFYDHFFDWGLKDEITKLIAIRSRNGIKPDSALRILASDADLYVAAIDEKIIAKIGSRYDVGNLVPPTYQVATSGKDYAVWEKKA
157
Q89YX0
1.11.1.24
ACT_SITE 44; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
MKNIGDKAPEVLGINEKGEEIRLSAYKGKKIVLYFYPKDSTSGCTAQACSLRDNYSELRKAGYEVIGVSVDSEKSHQKFIDKNNLPFTLIADTDKKLVEEFGVWGEKKLYGRAYMGTFRTTFLINEEGIIERIITPKEVKTKEHASQILNQ
12
Q6K461
3.6.1.52
ACT_SITE 160; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
MRQEATCSLVLTQDAQHRKNQPPLAEEDDDRDHTDDAMPPPCSILLRQEEGEATAAAAGEGLLVPPLNFAMVDHGVYRSGFPDISNLPFVESLRLRSVLCLCPEPYPEANQEFLRAHGIRLFQFGIDGSKEPFVNIPEDRIREALKVVLDVANHPVLIHCKRGKHRTGCVVGCLRKLQRWCLTSIFDEYQRFAAAKARVSDLRFMELFDISSLKHLPASFSC
190
Q502C8
1.11.1.24
ACT_SITE 47; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR637944-1"
MPIKVGQRLPAVEVQEEDPGNSLSMAELFSCKRGVLFGVPGAFTPGCSKTHLPGFIQMAGELRAKGVDEVACISVNDVFVMSAWGKQNGADGKVRMLADPTGAFTKAVDLVLNNAQLIPVLGNLRSQRYAMLIENGVVTKLSVEPDGTGLTCSLASNFLAEV
12
A8XFY3
2.7.11.1
ACT_SITE 228; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 586; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
MGLQRGMPLAQLGEPFGITPAAIENVSPGIDQCKDHRIDASMRSEPSDYFSDTTNTFHSSIHVVHPTINNGTRMNKKESSASETEIDIGDVRKCGEKADRQQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKIRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMNQILKAKLSMPHFLTQEAQSLLRALFKRNSHNRLGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASANGHEIFRGFSFVSNAVIEERKLIQKSIRSVPTAKTHPFTDDYEILEVLMISNIFIRPVNFQKIGNGAHSVVHKCQMKATPRRYAVKIVKKAVFDATEEVDILLRHSHQQFIVKLFDVYEDETAIYMVEELCEGGELLDRLVNKRALGSEKEVASLMSNLLYAVQYLHSQQVAHRDLTAANILFASKDGDPNSLRIVDFGFAKQSRAENGMLMTPCYTAQFVSVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGFTPFAMGPNDTPDQILQRVGDGKITMTQPVWDTISEDAKDLVKKMLDVDPNRRVTAKQALQHKWFGRKESLPDRPIQENGEKLDMTDVKFQTALDQTYKAISSAPSVTLRPVGSSALAKRRMKDILYANYTKKNVSANAW
99
A0A0K9P698
2.7.1.11
ACT_SITE 284; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186"
MESRQVKNEIEAPVPRRVVGLYSCPDHSSSGNFVDIAACMPVRAPTPVGFGDVEPRAISKMSENVENDGDYFGKIVVGDDGFVLQDVPHLTDYISDLSTHTNPLQHNKSYSSVKQYFVDPDDTITQNIVVQKDGPRGIHFRRAGPRQQVYFKSDEVNACIVTCGGLCPGLNTVIREIVCGLSYMYNVNTIWGIECGYKGFYARNTIPLTSKYVNDIHKRGGTILGTSRGGHDTIKIVDSIQDRKINQVYIIGGDGTQKGASVIFEEIRRRDLKVSIFGIPKTIDNDIPVIDRSFGFDTAVEEAQRAINAAHVEAQSGENGIGVVKLMGRNSGYIAMHATLASRDVDCCLIPESPFYLEGPGGLFEYITKRLRENGHLVIVVAEGAGQELMSEQSINMTDASGNNLLLDVGMWLSQKIKDHFTNIRKMVITLKYIDPTYMIRAIPSNASDNVYCTLLAQSAVHGAMAGYTGCIVGPVNGRHAYIPFHRIIDTQNKVVITDRMWARLLSSTNQPSFLNPVKKDVDEKKVDTVTPRLSNSPTFNYYIDEDVLEDQLLQ
84
K3YIN6
1.11.1.7
ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MGAQMKSFVRLLILVQVAAILAGHGAAELSMDYYGMSCPYAEYIVRNVVGQALMKDPTLAGSILRLHFHDCFVQGCDASVLLDSTDDNTAEKDAPANKSLRGFEVIDSIKEALEEQCPGVVSCADVLALAARDAVFMARGPYYGVPLGRRDGSRSVASDTFLTLPPPIKNVTVLIQIFDKVGLDVHDMVALSGGHTLGIAHCANFKNRIKDETETLDATLASSLGSVCKGGDSGKAPFDRTSTRFDAVYYRELTSKRGLLSSDQTLFESPETKEMVSMFAMNPDYFFYAFQQGMLKMGQINLKEGDDGEIRHTCRVVNS
14
Q8IE14
3.4.21.89
ACT_SITE 63; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P67812"; ACT_SITE 101; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P67812"; ACT_SITE 127; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P67812"
MDFIKEQYNSLVLDLRKTFRNKRDGLSHILNVICLLLNALMIWKLLVVFTGCESPVVVVLSGSMEPGYYRGDTLALYHPPKIHAGDVVVYQINGRDIPIVHRILSLHTSKDNKFHLLSKGDNNNIDDRGLYDPHQYWLENEHVLGLSVGYTPYIGILTIWINEYPVVKWAIVSIMLIMILMGYE
178
A0A3B6FYB3
1.11.1.7
ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MATSSSVVVLAVLATVAALVSPAMSLPVFTGDVGVSPGFHAASCPQLDGVVRSSVVAALRQEVALAAGLLRLYFHDCFPQGCDASILLNTTSARAGPVLGRGERGGRPGPPKARGPLPAGQQQDLSSLRPNNRVMSSTGRKYSSVSHKRKKEEGGRLMAIRKMMVILLQKAMLTSTWMIAIVAALVESFGTRGLGDVADLVALSGAHTIGRSHCGSFADRYRRADDTFSRKLAANCSKHPDRLQNLDVVTPDLFDNGYYKALRFNQGVLTSDMALVKNKTTAAIVKRFAQSKDAFFRQFARSMEKLARAPKPAGNVGEIRRFSCFRTNAQRADAAVDAAGEEEEGFAASA
14
Q5P7I0
1.3.3.3
ACT_SITE 107; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333"
MGAPDSRVVRQHLLDLQSGIVAVLERFDGGRFREDAWQRPAGGGGITRVIEEGRFFERGGVNFSHVIGGAMPASATAHRPDLAGRTFEAMGVSLVLHPRNPYCPTVHMNVRFFIASHPEAAVPPPAAAPVWWFGGGMDLTPYYPYEEDVRNFHRACRAAVLPWGGEPEYRRLKEWCDRYFFLKHRNEPRGVGGLFFDDLGADGKTDFDAAFGLARSVGDAFLDAYLPIIERRRDVAYGERERDFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSLPPVVKWRYDWQPEPGSAEARLYDEFLAPRDW
27
B8E0S5
2.7.1.11
ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00339"
MIRRIGVLTSGGDAPGMNSAIRAIVRFGISKGIEIIGIERGYQGLIEGEFKVLSRDDVSEIVQKGGTILRTARSDEFREEEGQKKAIENMEKHGLDALIVIGGEGSLKGAYDLFKKGINVVGIPGSIDNDVWGTDFSIGFDTACNNVIDAINKIRDTAAAHERTFVIEVMGRECGFIAFTSGLVSGADIILIPEVPIDFPYITEKLRERQKRKKRHNIIVVAEGVGSAYFIGKQIEDKLGISTRIVVLGHIQRGGSPSVFDRNMATFMGVEAIKRLLNGEGGVMIGWQKNSPVPISLEEVSKYKKRVPPELYWEVECLW
84
A0A9J7LW94
3.1.4.11
ACT_SITE 266; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 302; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"
MFFCMHKYLANLPKDKLKEMVQFGPPDIPVENKTVTVVYGPDMVNISFINFVSNSEGVAKIWTDSLLKIATNVLALNASPMQNLKKVYAKLIVKDLTKEGKLPVKNVIKLFSTSKEERKRVEAALATCSLPTGKNDVINVEKFFFEDFITIVRKVCPRPELDKVFAEVGTKKPYLTMEQVVDFLNKGQRDPRLNEILYPYANNKKALDIISRYEPNKSYANKGHLSVDGLYRYLMSDENTMVDPVKFDLSDDMTQSLSHYFINSSHNTYLTGGTVCCSSLIWMSMCGAGLLDGNDNEPIITHGYTMCTDVLFKDVVEAIAESAFKTSDWPIILSFENHCSPKQQAKMAMHCRTTFGDMLLVEDIYGYPLSAGTPLPSPKDLLGKILIKNKKKIKKRAAPGEIKDKDIVENGNKDMQENGLDDESGVDESLAEEKAAEDSGEKGAGDNTNIVPEEERRGSATIPAPASATTTASPGIEKMNSVSADQPEADEYGDDSESEEEEEEDEEKKKRRQEQKRDKGTAGQETDAVAEMSALVNYIQPVHFHSFEISEKRNRSFEISSFVETAALASLKEFPVEFVNYNKRQLSRIYPRGTRMDSSNYIPQVFWNAGCQLVALNFQTLDLGMQLNMGFFEYNNRSGYILKPDFMRRTDRHFDPFAESTVDGIVAGTVTVKVISGQFLTDKKVGTYVEVDMYGLPADTVRKRFRTKVVPANGINPIYDEEPFVFKKVVLPHLAVLRISVSEENGKFIGHRILPVEGLRPGYRHVVLRNEANQPLNLPTVFVHITVKDFIPDSFEDFANALANPIAYQAMIEKRAQQLEALMEDDDISTTEEDGRPKMTPGEKTSGTPVQRSLSSGSTNMEQLSSTANARKGSSPNTANIHSAVSRVASSTSVEPSAVQIEKGRKSLTSGVLTPSLSIDQTINKSLSSPEGEKEPPAEIFKPLTIQELKQLKTFKKLQDKQQKELAALSKKQEKIRGMLRKSQTLKEDKLLTLQAKDRLALEKCHAKALKKANKAQAGAVEEEVKRKSSAEMEKFLKDYEQQLVDLRQAHYQAGLSTWKEHCLQEKELKMKHTGLMYVTLHQQMTNSQQTQMGKVKEIHDKEVKDLKQRLDQQRKEEERALAKRCKDRNELARLKRETQQKHIQVAVQHRQQLDEIHSNRTEELQKNHKEIEEAISKEEEKANAEIMVEYEKKSKDLPETWRALQEEKDAASSSINGPSTPTGTSL
153
E3KAQ7
5.3.1.8
ACT_SITE 308; /evidence="ECO:0000256|PIRSR:PIRSR001480-1"
MSSPSPIVELIPQVQSYDWGKLGKDGSKVAEYSKHLPNFHYDPEKPYAELWMGTHSSLPSKLIDGKLLSDHLASDPAQLLGKQISNQYGSHLPFLFKVLAIGKALSIQAHPDRQLAIKLHKERPDVYKDDNHKPEMAIAITPFSGFCGFRPLNQISQYLEKVPEFATVIGQETSSRFLEAIPSDASMPSIISSTSTDQTDVKNYQAVLKELFGKLMNASSELVTEQVRKLIKRIEAEGGRDKPFGTDEELLLRLNDQFPDDVGIFCTFVLNVVRLEPGQAAFLQADEPHAYLTGDIVECMASSDNVVRAGLTPKLRDVPTLTEMLTYSYGPSASQLMKPNLFKSCKHSTLYDPPIEEFSVLLTKLSPGEQDQHPPINGPSILIVTQGSGTIAIEGQEISSKHEGQVYFIAAGMPVQISAQQSSFVCYRAFVEIAGQA
214
B3SA37
3.4.19.12
ACT_SITE 88; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 163; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"
MADDDGAGNWCLIDSDPRIFTELIKGFGVTGVQVEELWSLEKEEFEKLKPIHGLVFLFKWRPGEETVGSLVQDSRQIYFAKQVINNACATQAVLSVLLNCNHKDVQLGEMLYKFKEFSADFDPTMRGLSLSNMDIIRQVHNSFARQQMFEFENSSNKSEEAFHFVAYVPINGRLYELDGLKDGPIDLGKCGEDWITAVKPILESRMTSYATGEIRFNLMAVVSDHKMKLEADLEKLQSNLSDLEGKLSKLDTKKDTEAYLKLKNEYATVELKMNEANHQLRVEEEKRLRYKIEHAKRDHNYLPMIVQLLKCLAKDGRLVELTEKAEQRQKAVTAAALERRKRKLDSGKESSDDKDSGK
175
H2LLI2
3.1.4.11
ACT_SITE 331; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 376; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"
MAGAKPGVHALQLKPVSVHEDLKRGGKFIKWDEDPNGGSPTLVTLKVDPDGFFLSWTAGSNLEVEILDISTIRDTRTGKYARQPKEAKLQSMLSVGKDSFLGKSLTIVYGNDLVNISYLNFQAMSEDEAKLWTEELFSLATNILSHNATRNSYLLKAYTKLKLQVNQEGKIPVKNIMKLFSDKRRVETALEQCGLVRNKSEGIKPDDFTWEAFQKFLNNLCLRPEIQTIFEESSKKKPFISLDQFMDFLNRRQRDSRLNEVLYPPLKREQVRQIMEKYETNSSQLDRDQISLRAFSLYLGGEENGIVPPERLDIIDDMNQPLSHYFINSSHNTYLTVGQLTGLSSVEMYRQVLLTGCRCIELDCWQRQDEEPHITHGFTMTTEIPFKDVIEAIAESAFKTSPYPVILSFENHVESPKHQAKMAEYCRTIFGDALLIDPLEKYPLVPGQPLPSPQDMMGKILIKNKKKHHHHRPSETSVRRKELEEPSSIPNDCPLSDGDGNQTLSNGEEKLAESLMKEVEPRKSIAEGESEEEEEDESATETKKNSDEGTASSEVNATEEMSNLVNYVEPVKFKSFDLAAKKRKYFEMSSFVETKGMEALKNSPVEFVEYNKNQLSRIYPKGTRVDSSNYMPQVFWNVGCQMVALNFQTLDLAMQLNMGVFEYNGRSGYLLKPEFMRRMDKHFDPFTESIVDGIVANTVKIKVVSGQFLTEKKVGVYVEVDIFGLPADTKRKYRTKTSSNSNSLDPVWDDEMFVFNKVILPSLASLRIAVCEENGKFIGHRILPISSIRPGYHYINLKNELSQPLLLPSLLIYIEVQDYVPNEHQEYADALTDPIKYISQLAKREKQLASLIDDNVEQQDSSQPKDSIRRTSITTAGFQPLPSFQPPTLSPIEDCPDVIIKPPPPVQTPVQKEDPIATILAEMQVLSVEDLKQQKNYVKLVKKQEKDIKELRKKHLKKVCSLYKKQKSQSSQVESDTHKKRSQMEKSLKRSIKKNEPQEGMKKELTKLEQEVEEQTVKMWEGQMEKLVKLRQELHVLERQMQEKHLHEAFQRLKDICQECQAAQIKKLKESCEKEKKELQKMLERKRLNSISEAKNKEEQEKINTKHISESVSLFRKLETEQEKRQDKLIQKYTEMLQHIQEELPTLQAQLAQDLQEEFHRLPEEIYQHLNLERHNKSLRRFSNNSSPGSNCGTRSLPSTPDQSLLNSSMDRSTSSLADSCSPSTTPVHSEAEISFT
153
D8R0U5
3.1.1.11
ACT_SITE 169; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MERERRDGNKLIQLEATVAKAVVSHDPDYGSHTSIQAAVDDAPDHLNRRYTIYITAGVYDEIVRIPSTKTMIAFVGDGINKTVITGNLSTVMGISTYRTATVAVSGNGFLMRDITVVNTAGPGGQAVAMRVDSDMAAIHRCSFWGFQDTLYTHAYRQFYRDCSIYGTIDFIFGNAASVFQNCNIQIRPGAANHTMSTITAHGRTDPAQDTAFVCQSCWISGTPEYLEARLAEPGKHQGFLGRPWKPYARAIFIESYLDVVIDPSGWLPWNGTLGLDTVVLAEFHNYGPGASPIGRVGWSKQLNTIAALEYSVRGLIQGGYWLPFTGVPYRLVF
125
Q5A0H3
3.1.3.3
ACT_SITE 88; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 90; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"
MTYVLTAISHNDSKFETETLDSIKEFISNNFTLVSSKELSPRAIDYVISINDFESSKENVKEFSISKSFDLVIQLESSRKTKKLFIFDMDSTLIYQEVIELIASYADIEDKVAEITTRAMNGELDFNQSLAERVLLLKGIDASSIWDELKLKIQVTNGVPELCKALKKLNIIMGVCSGGFIPLAEFLKEKLGLDYAFANTLGIDDSNRLNGTTVGPIVNGEKKAELLLDIAKKHKIDPSDAVAVGDGANDLKMMFVAGFGIAWNAKPKVQKQAPACLNTKSLSDILYIMGYNDKEIKELID
147
P38624
3.4.25.1
ACT_SITE 20; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:9087403"
MNGIQVDINRLKKGEVSLGTSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL
180
B9GXZ8
3.1.1.11
ACT_SITE 422; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MLVAKMTQDKQSLTGISDSGKHISIFKKNKKLFLVILASLLLVTAIIAIVAGVNSHKSSKNEGTHAILKSSCSSTLYPELCYSAVATVPGATSNLASQKDVIELSINLTTKAVQHNFFTVEKLIATKKLTKREKTALHDCLEIIDETLDELHEALVDLNDYPNNKSLKKHADDLKTLLSSAITNQETCLDGFSHDEADKKVRKALLKGQIHVEKMCSNVLAMIKNMTDTDVANELKTTNRKLMQEKEGNESEWPEWMSVADRRLLQSSSVTPDVVVAADGSGNYKTVSAAVAAAPKKSSKRYIIRIKAGVYRENVDVPKDKTNIMFMGDGRKTTIITASRNVVDGSTTFNSATVAAVGQGFLARGITFQNTAGPSKHQAVALRVGSDLSAFYDCDMLAYQDTLYVHSNRQFFINCLVAGTVDFIFGNAAVVLQDCDIHARRPNSGQKNMVTAQGRTDPNQNTGIVIQKSRIGATSDLQPVKSSFPTYLGRPWKEYSRTVIMQSSITDVIQPAGWFEWSGSFALNTLYYAEYQNSGAGAGTSRRVTWKGYRVITSATEAQRFTPGNFIAGSSWLRSTTFPFSLGL
125
A0A9J7N4H4
3.1.1.4
ACT_SITE 72; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 120; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"
MKVVLAAAILLVVGFGFEGAVGKPTRSVLQFGAMISHVTGRNPFDYLDYGCYCGLGGSGTPVDDIDRCCEVHDACYGAVDSSDGVGTAHLINYHFTQEAGGLVTCDDRFGTVAREACECDREAAFCFDRYPYPGRQPC
130
A0A3Q2HRA5
4.1.1.17
ACT_SITE 337; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MRPFVTDFCHLKKILPFVTAWMDLEDITMSEIVTEDKYCMIKKHLRWLKALPRVTPFNAVKCNDSRTIVKTLADVGTGFDCASKTEIQLMLSLRVPPERIICANPCKQVSQVRYAANNGVQMMTFDSEVELMKVARAHPKAELVLRIATNDSKAVRRLSVKFGATLKTSRLLLEWAKELNIDVIRVSSHVGSGCTDPETFVQAISDARCVFDMGAEICFSVYQLDIGGGFPGSEEIRLKFEEVTSVINPAPDKYFASDSGVRVIAEPGGYYVASAFRLAVNIIAKKLILKEQTGADDDESSEQTFVYYVNDGVYGSFHCILYDHAHVKPLLIWGPTCDSLDCIVERCNLPQMQVGDWMLFENMGAYTVAAACTFNGFQRPAIYYVMLGPTWLDFPHEVQEQDISTLPVSCAWEKRHPAACASASINV
195
Q10452
2.7.11.1
ACT_SITE 157; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MNHGTKIPVDPFRIIKETARDGSTGEVKQLSYTSSKVVGSGSFGVVMQVHLIESDSKAAIKRVLQDKRFKNRELQIMRIMKHPNIVDLIAYYYTTGDNSDEVYLNLVLEFMPETIYRASRLYTRQKLSMPMLEVKLYIYQLLRSLAYIHASGICHRDIKPQNLLLDPENGILKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATDYTHAIDIWSTGCVMAELMLGHPLFPGESGIDQLVEIIKILGTPSREQIKTMNPNYMEHRFPQIRPQPLSRVFSRSVPLDALDLLSKMLQYTPTDRLTAAEAMCHPFFDELRDPNTKLHNSRNPDASPRHLPELFNFSPFELSIRPDLNQKLIPSHARDALPVKLDDFVPIPIHRARID
99
Q8C6M1
3.4.19.12
ACT_SITE 154; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 645; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"
MGDARDLCPHLDCIGEVTKEDLLLKSKGTCQSCGVAGPNLWACLQVTCPYVGCGESFADHSSIHAQVKKHNLTVNLTTFRVWCYACEREVFLEQRLAVHLASSSARLSEQDSPPPSHPLKAVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKLISEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPMVAAVAALTDARDSDSSDTDERRDGDRSPSEDEFLSCDSSSDRGEGDGQGRGGGSSKAEMELLISDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMASLDEQSREAQPPSPRSTSPCQTPEPDNEAHIRSSSRPCSPVHHHHEGHSKLSSSPPRASPVRMGPSYVLKKAQVPSTGGRRRKEQSYRSVISDVFNGSVLSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGACGDSYSSQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLCLPEILCVHLKRFRHEVMYSFKVSSHVSFPLEGLDLRPFLAKECTSQVTTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNVEAYVLFYRKSSEEAMRERQQVVSLAAMREPSLLRFYVSREWLNKFNTFAEPGPITNHTFLCSHGGIPPNKYHYIDDLVVILPQSVWEHLYSRFGGGPAVNHLYVCSICQVEIEALAKRRRVEIDTFIKLNKAFQAEESPAVIYCISMHWFREWEAFVKGKDSEPPGPIDNSRIAQVKGSGHIQLKQGADCGQISEETWTYLSSLYGGGPEIAIRQSVAQLPDPESLHGEQKIEAETRAL
175
A0A3B6B876
1.11.1.7
ACT_SITE 94; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MACSRAMVALMGLVLAALLFPAALSSRRPDQLISMTTDGQYHSTRPVVTIADGLTADYHDVSCPDLQGIVRTAVVEALQGDITIAADLLRMFFHDCFPQGCDASILLLGTPWSEMRMPPNLSLDIRRKVAFLMEDIRAKVHEACGPTVSCADIMALATHDAVIASGGKPYHVPLGRLDSFEPAPLRFVEELPPPTFSIGQLIAAFKSRSLDEKDLVVLSGAHTIGKAHCATFSDRFPNSDSDDFVRRLQDNCTADVNRRQDLDVTTPEKFDNKYYINLKQGKGVLTSDVQLLLNETTRGYVNDFADNEWWFWNQFGSSMSKMGMLQGPQGNVGRIRQQCY
14
A0A5F8GXA8
2.5.1.18
ACT_SITE 16; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1"
MANLPRKLELFYDVLSPYSWLGFELLCRYQNIWNINLQLRPSFIPGILKDSGNKPPALVPRKGKYMMMDLQHLKNFYQVPIRIPKDFLTVILEKGSLNAMRFLTAVNMEKPEMLENVSRELWMRIWSRDEDITEPWSIQAAAEEAGFSRKQAMSLLKKSSTEEVKNKLRENTNTAYKYGAFGLPTIVAHMDTKPCVFFSSDRIELLAHLLGEQWQGPVPQALKGKL
77
H3GAG9
4.2.1.11
ACT_SITE 242; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 377; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"
MSKPSLLQRTCWCLVCAFKSDLTFLANGSGRNHHLFLSIHAREIIDSRGNPTVEVDLTLSGSAEIFRASVPSGASTGIHEAVELRDGGKRYAGKGVQQAVQNVKSVLAPKLIGADPTKQRDIDNLMREIDGTENKGKLGANAILGVSLAVAKAGAAAKGVPLYQHFADLIGNKNLVLPVPSFNVINGGSHAGNKLAFQEFMLLPTGAESFSEAMVMGCEVYHQLKSVIKKKYGQDATNVGDEGGFAPNIQSNREGVELLMTAIGRAGYDGKIGIGMDVASSEFLTKEGKYDLDFKTEGSTDLLTGEELGQLYKDLAKEFPIISIEDPFDQDDWTHYSSFTAGIGEKVQIVGDDLLCTNPKRIATALDKKACNALLLKVNQIGSVTESVDAVALAQKNGWGVMTSHRSGETEDSYIADLAVGLATGQIKTGAPCRSERLAKYNQLLRIEEALGSDAKYAGVHFRNPSKM
200
Q9FX43
2.7.12.2
ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MALVRERRQLNLRLPLPPISDRRFSTSSSSATTTTVAGCNGISACDLEKLNVLGCGNGGIVYKVRHKTTSEIYALKTVNGDMDPIFTRQLMREMEILRRTDSPYVVKCHGIFEKPVVGEVSILMEYMDGGTLESLRGGVTEQKLAGFAKQILKGLSYLHALKIVHRDIKPANLLLNSKNEVKIADFGVSKILVRSLDSCNSYVGTCAYMSPERFDSESSGGSSDIYAGDIWSFGLMMLELLVGHFPLLPPGQRPDWATLMCAVCFGEPPRAPEGCSEEFRSFVECCLRKDSSKRWTAPQLLAHPFLREDL
108
A8XUK9
2.7.11.1
ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1"
MSADVIKRSNPADDYELLQRVGSGTYGEVYKARDIRSDTLAAVKVVKLEAGDNFAVIQQEIMVIRECSHPNIIAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTGPLSELQIAFVCRETLRGLNYLHNMGKVSFRSIHRDIKGANILLSSNGDVKLADFGVAAQITATIGKRKSFIGTPYWMAPEVACVEKRGGYGMLCDVWATGITAIELGECQPPLFDLHPMQVLYLMTKSGYKPPHLKDKHRWSPLFHDFVRQCLTKNPKKRPSPEKLLTSHPFVLGSLSARMTRDLLDKVNGAPSDVYDRMSKTVDDLTEEESDMDDAPPLLTPDAAPIKIGLPAHLNGLRLDAKCLEQLTSSPHSTSSETDRKTPTATPRGLNRGYHSERTLPAKEMQSLPDVIGGDALLHCASGNGVIHDDDETIRAPRAPPRTLRAAQKAAASGSENRFSSTSIASTPSEDSMSTFFGMPIIPKVPMGACFSKIMDGTDLKINCAASWVHPLTGAHLLLFGTEQGIYSFDTNCLPDGNLTKIHHRRCSWMFVYSDRLTAIQGNTPYLYRHDLIALTQKNLTLKMSKNLNKIPEKYVPKRLAITVRMPETRGALQCTVKQGEGAQSSSLFLCCAVPKTVHLFQWYKPMNQFVLVRSEPLREDIRFPIRPFALVNSRASDFPELCIGVGRMSGASEFQFNMVNFCSSTRNSEVSDGYNSSFGSLAEDEMLEVGNMHQIDRNTLCFSFRNKVVMTDLEGFERPKPSIFTFNFHIEYLHVVDETILAFHANGVQGRDLKTNLNTQDLCDVSRLYRVIGDDRVIILRSQLMTARNAGDTLDISLLMGHSDTPTL
99
A2DZQ0
4.1.1.17
ACT_SITE 343; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MHHVAPHDNFTIIKNLDNTVQKCLEQMDNDQAFWIADFNRIRRSLALWEENLSRLHIHYAMKCCDEPELLKFLADRGVAYDCASEDEIRRILALGVDANRIVFAHPIKSIDSIKYAKENGVTRLVYDTESELRKILRYYPEAEVFLRIKPRFTHAKIQLSNKFGADPKEVPKLMQLASELGANFIGFSFHVGSLCDDITTFRVALEYVAELKAKAEQLGLNVSFIDIGGGFLPPSIKAKYTFAEIAEAINTAIDELFDGDEIEFLAEPGRFIASDFMDLVMPVICVKEHHDPDGDEQAVFIAEGIYGAFNALNYDHAEPHFLIRTEGASEGEMIKTRLWGQTCDSEDLVYEELSWPRLEVGDYLMIEKFGAYTYAPTSFFNGFMHHKVFHINEEDEE
195
A0A9R1WBW9
3.1.1.11
ACT_SITE 372; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MARISKLFFPFILYVLFVCTSISWCLQEDGESDSDINYWCDTTPHPQQCKYFLSSGTHHTPRHRKDFRMLVLEVALQKAQEAQTCSNDLRNKCKSKRKKAVWLDCNKLVNQTILQLNQTLISFKHNQSSDFDAQTWLSAALTNLETCFSGSQDFNLTNFVSPLKSHNLTEMISNSLAINQFFLKQKSATNDDRELDNDFPTWVTPGDRKLLQTGSLRTKANLVVSQARGSKFRTIQSALKYAAGYNRRNRRYIIYIKRGVYKENIEIGNNLNNIMFLGDGARYTIITGSRSVGGGFTTYSSATVGVDGTGFIARGITFRNTAGPAKSQAVALRSSSDLSVYYACSFEGYQDTLFVLAQRQFYKTCYIYGTIDFIFGNAAVVFQNCMILARRPLKGQANIITAQGRGDPFQNTGISIHNSRVMAAPDLKPVVRTVKTYLGRPWQEYSRTVYMKTFLDSHIDPVGWSPWDNTNFAQSTLVYGEYQCFGPGSSTRNRVKWRGYSVITSASVASQYTVERLIAGRSWLPATDVPFTPGL
125
A0A3B6LHZ7
1.11.1.7
ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MARPAPSPLLLLVVLAGALAGGGEAALLKAHFYRPSCPAAEAVVRDIVLARVAADPAALPARLLRLFFHDCFVRGCDASLLIDSTAGNTAEKDAGPNGSLGGFDIIDTAKAVLEAVCPGVVSCADIVALAARDAISFQFGRDLWDVQLGRRDGVVSSASEALSNIPSPSDNFPPSRPNSPARASTSRTSSFSRRAHHRRRPLQPLRQPPLQLHHHRCCPRHRPDPQRRLRHSAARRVWVALQQRHRRAYGPRQPCPVRLPLLRQPQARPWPVPLRRRTAADRRAAGMIHALTKEGYFLQEFKNAVRKMGRVGVLTGGQGEIRRNCRAVNS
14
F2DP54
1.11.1.7
ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MASRAAAALVVVAMACAVVHSAAAAAGELSPDFHAGSCPDLEHIVQYHVAEAFRKDVGVAPGLIRIFFHDCFPQGCDASVLLTGNNSEQALGPNLTLRPVGLNLIETIRAAVHRSCGRTVSCADITVLATRDSVVLAGGPRFEVALGRRDGLAPASQDLVFTLPAPSFTVPELLKSFGDRNLDKADLVSLSGAHTFGIAHCPAFSDRFTPEVDTNPAIDPNFAAKLKAKCANDVPALSVNQSLDVRTPDVFDNKYYFDLIAKQGLFKSDQGLIVHPETTRMATRFALNQGAFFEQFAKSMVKMSNMDLLTGSQGEIRFNCAVPNSRVDGIETASDEGHASAM
14
Q8YZ37
1.3.3.3
ACT_SITE 96; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333"
MKQLQDEITQALTKLDGGSEFHEDSWERPEGGGGRSRVLRDGAIFEQAGVNFSEVWGSHLPPSILAQRPEAEGHGFYATGTSLVLHPRNPYVPTVHLNYRYFEAGPVWWFGGGADLTPYYPFAEDAAHFHQTLKLACDEHHPEYYPVFKRWCDEYFYLKHRDETRGVGGLFFDYQDGQGVLYRGPNPKGEAANYSNQVGEPASRDWEDLFSFIQGSGKAFLPAYVPIVERRHGMEYGDRQRNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYGYQPEPNSPEAELYDTFLKPQDWSNWTANQ
27
Q8EDG1
3.5.4.5
ACT_SITE 103; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01558"
MQDRFIRSITQLPTPLADALIPLLHQGFAGHIDAQHLAELVKSSNMTESEVLLALLPIAAALAKPPISEFYVGAIAKGKSGDIYMGANLELPGEALFHSVHAEQSAISHAWLSGESQIVDMIVNASPCGHCRQFMNELVDGGQIKIHLPSQDSHLLSYYLPYAFGPKDLNVQSPLLVKQETEFALDSSDPMVIEALDHAGLSYAPYTQSYAAVVLETADGATYCGRYAENAAFNPSMLPMQMALSNLTRHNRDFAEIRRAVLVESSQGKISLVGAAMDALHAVAAIELEHIVVDPI
187
P83673
3.2.1.17
ACT_SITE 84; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01257"; ACT_SITE 95; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01257"
MNGLILFCAVVFATAVCTYGSDAPCLRAGGRCQHDSITCSGRYRTGLCSGGVRRRCCVPSSSNSGSFSTGMVSQQCLRCICNVESGCRPIGCHWDVNSDSCGYFQIKRAYWIDCGSPGGDWQTCANNLACSSRCVQAYMARYHRRSGCSNSCESFARIHNGGPRGCRNSNTEGYWRRVQAQGCN
160
B6TKH0
3.1.3.16
ACT_SITE 289; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1"
MDATANSDVQRAEEFKLKANDAFKANKFSQAIELYSQAIELNSSNAVYWANRAFAHTKLEEYGSAVQDATKAIEIDSRYSKGYYRRGAAYLAMGKFKEALKDFQQVKKICPNDPDATRKLKECEKAVQKIRFEEAISAGDDERRSVADSIDYHIIEVEPHYAGPRIDGEEITIEFVKAMLDEFKKQKCIHKRYAYQIVLKTLDLLRSMPSLVDVDVPNGGHFTVCGDVHGQYFDLLNIFDLNGLPSEENPYLFNGDFVDRGSFSVEVILTLFAFKCLYPKAMYLARGNHESKSMNKIYGFEGEVRSKLGEKFVELFAEVFCWLPLAHVINNKVFVVHGGLFSVDGVKLSDIRSIDRFCEPPEEGLMCELLWSDPQPQLGRGPSKRGVALSFGADVTKKFLQENNLDLIVRSHEVKDEGHEIEHDGKLITVFSAPNYCDQMGNKGAFIRFTAPEMKPDIVTFSAVPHPDVKPMAYANNFLRMFQ
144
Q8GVN8
1.11.1.7
ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MQQLLAMKLILTTLVVAVLALSAGTATATCDTLTVGHYRQSCRAAETIVRDTVKLYFSKDQTVTAPLLRLHFHDCFVRGCDGSVLLNATAASGPAEKDAMPNQSLDGFYVIDAAKAALEKECPGVVSCADILALAARDAVSMAAGNINGASLWQVPTGRLDGRVSSAAEAVANLPSSFADFAKLKEQFGSKGLNVQDLAILSGAHAIGNSHCVSFAKRLYNFTGKGDADPTLDRAYAAAVLRAACPPRFDNATTVEMVPGSSTTFDTDYYRLVASRRGLFHSDQALLQDREAAATVRVMARSSRQAFFRRFGVSMVRMGNVGVLTGAAGEIRKNCALIN
14
P52034
2.7.1.11
ACT_SITE 168; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03184"
MNSEINQRFLARGSQKDKGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRGGTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTITTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSAGQRLNIVIVAEGAMDREGHPITAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVVISLDGNQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKPPKENFDADGKGIEGYRLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRTLPEGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEGKGLFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATLLGIVSRQYRFSPLVDLIAETNFDQRIPKKQWWLRLRPLLRILAKHDSAYEEEGMYITVEEECDTDAVA
84
A0A0A0L1E1
6.3.4.4
ACT_SITE 81; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 109; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 209; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134"
MNISSLAFEPTLFSAANLSPSSACRRPFSGRHPPLIVCSSAKTVAAVSSSVSVPESGRKDGLKRIGELSQVSGVLGCQWGDEGKGKLVDILAQHFEIVARCQGGANAGHTIYNAEGKKFALHLIPSGILNEDTLCVIGNGVVVHVPGFFEEIDRLEASGVSCKGRILVSDRAHLLFDFHQEVDGLREAELAKSFIGTTRRGIGPCYSSKVIRNGIRVGDLRHLDTLPQKLDLLLSDAAARFKDFNYTPEVLKEEVENYKRYAERLEPFITDTVYFINEAISANKRILVEGGQATMLDIDFGTYPFVTSSSPSAGGICTGLGIAPKVVGDLIGVVKAYTTRVGSGPFPTEILGKGGDLLRFAGQEFGTTTGRPRRCGWLDIVALKYCCQINGFSSLNLTKLDVLSELSEIQLGVSYSTPDGTPVRSFPADLSLLEQIKVEYETMPGWMCDISSIRDYSDLPKAAKEYISRIEELVGLPVHYIGVGPGRDALLYK
253
Q26614
2.7.10.1
ACT_SITE 781; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028"
MSLPRCPRTRTVMFSRTLTRCYPQRTLWIAILCVICSWTLSTAGATTIRDKEVKPDAPQDLTAIPVKAEAIVLTWKKPLKGQTDGYIVVYCLKRNKGNGCERQKIEGGNVTEVEVTNLYANHTYQFQVQSWYSDHPKGASTGYIEASGTPPIPPTLRRNFKGLVEKSLGFEHKIPCPVKADPRPYTRWLKNGTDLTPNDPDDNVSFTKTSIVFKRLRFSDAGLYTCVASNFFGQPIHVNFTLIVVDTHSESYAESSVLESFSSLELETGPYNETEEEETHFPRFTDTERMEPEKPLPSNTKVRLECGARGTPTPNITWIKDGVQKWKINVIRPTRVEEKGFVLIIRRAIVRDTGKYTCIVSNQYGTIEHTYDVKIRERLPVKPIMSPMKNVTATVGSNTSFVCRVVNDLTPHFAWMRFNGTNNTKQRLTDIDDHISILQQRWVEEPMLTCDEFLDVFYQNQSKRMLECLHLIQLETQGGMEEANQLKLYNVQYEDEGPYLCVAGNFYGMSWEGAYLDVVEPTTQAPVRTNPPAVYIPNNMQPTSKTQLIIFSVVGFVVVLILVTCIAILCKQTQVRHRRPSDKPDISGPKHLYRQTSVDSTQSIAPLFGGRNRLTSSLTVISEYDIPLDPEWEFPRDRLTVGKTIGEGAFGKVVIGEAVGIVCQEKTSTVAVKMLKANAMDREFSDLISELAMMKMIGKNPNIINLLGCCTQEGPPYVIVEFAHHGNLRDFLRSRRPPEEYEKSILLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYIDFYRKTTDGRLPVKWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGGTPYPSVPVEQMFDYLRSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDLDRIISVSSNQDYLDLEAVGDAPVKTFQESERMAFMGFRAPLSPQVYYKVPQTRDCCPYAN
97
A0A3B3I798
2.3.2.26
ACT_SITE 763; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104"
MSNQGVRRNGPVKVRLTVLCAKNLAKKDFFRLPDPFAKVVVDGSGQCHSTDTVRNTLDPKWNQHYDLYIGKADSITISVWNHKKIHKKQGAGFLGCVRLLSNTINRLKDTGYQRLDLNKLGPNDNDTVRGQIVVSLQSRDRIGTGGPVVDCSRLFDNDLPDGWEERRTTSGRIQYLNHITRTTQWERPTRCPEAVRDGEETGNGDKYRPASEYSSPSGRPSSCVVDENTPVMTPVNGAVASCPLGEQRVQERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNVNCEELGPLLPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNSPSPNGSRVAMDSQNTNLSSNQSQLKDQGGPVGPPQALSPAQLPEEAECLTVPKYKRDLVQKLKILRQELSQHQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGLAVFHGHYIDGGFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILGNDITGVLDHTFCVEHSAYGEIIPHELKPNGKSISVTEDTKKEYVRLYVNWRFLHGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDIVDWRSNTRLKHCTTDSNIVKWFWKAVESFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDANANNLPKAHTCFNRIDIPPYESYEKLYDKLLTAIEETCGFAVE
65
Q5AUW5
3.2.1.21
ACT_SITE 324; /evidence="ECO:0000250"
MRVPSLSVLSFLLGTALAAASNFEAGLLSSGKVSLGDWKSAHEKASQFVAKLNTTEKIKLITGSSVTTTNGETFTALDILDGDMGAQAYYYVSAFSLSSALAMTWDKEAMYEQGRAIAAEFYGKGIQMVAGPTSQPLGRTPWGGRLVESFGPDPYLNGIATGLETRAYADVGVIAGAKHFILNEQETNRTGGMGGGGGAPGGGGMGRGAEFSSSVPGGMSPTSSAGAIPSSTSTPGGSGMGGGMAGSSAFSSSSSSGAPYSSNADDKTLHETYLWSFYDAVHSGLGGVMCAMTKVNGTLSCQSSSLLLDILKTELGFPGMVWPDTNGQQDALASAANGLDYGSSSLWSESTIEGYLESNNITEARLNDMAIRNLMGYYYVNLDNGTQPSTAAQDDYVDVRANHAKLIRSHGSKSMVLLKNKNNTLPLYKPHKMAIFGSHARAAVAGPNMQFSVEGSGPTYDGHIATDSGSGQASLPYLITPENALNIKASQDGTMLRWIANDTYSSSTGSALVMQGSSSTSVTPSVSAYSENMDVCLVFINALAGEGADRTELRNTDQDNLINEVADNCDNTVVVINTVGARILDSWIEHENVTAVLYGSLLGQESGNSIVDVLYGDVNPSGRLTYTIAKTESDYNVDICYTAQCNFTEGNYIDYRYFDAYNVTPRYEFGYGLSYTDFAYSNLHIQGPSALSTYPTGQLAVGGYEDLWDTVAKVTVTIRNAGSLDGAEVPQLYISYPDVAKQPVRQLRGFHNVYIKKGQSTKVTFELRRRDISYWDVQHQKWAVAPGTYEAWVGASSRDLRTHGSFVVKTKA
161
A7T196
2.3.2.26
ACT_SITE 728; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MVPESKYRFHNRHCLAKKGLQIYLFGHYLQPRFTKVKWEWQDPQVVGETLTFLLQIRHNYTPFTVKRTDIDIEIVHDGTPIACSLDFGGPGWQEMNRVKVTFTVRKSGDYNIAVLAMGEHITGSPFAKVFLPGSVDPAKCTIIERSSILVLQQGVYSPLLVEARDVYGNLRSISNAEDLLKYKVHIKKIGGSDSIDPELFVDSENRSNNSLHIKLEDEGIFQGTVSYDGTPVNNGELTIISLNDSEWYAVEKNIDRHCYNVWYEAALLPYPLTGSNTPPSIGNGADVARKSRKVYCYISPRNVSIKEFYMRIFPHKLHAFRVSPRTKFTLHPPNSNYEHPAFTISDGAQAPVSVVCRDRNVLVATYSRLVLLNIGGSESFKKKREFFNEKLLSHQGMKGGEVRLKINRSNLLESSYVACKNVDWLKMFNVTFEGEEGLDWGGVRREWFELLCIALFGRDSELFTRFKGDDPQAPVHPNPRRPPHLNLKYYKFAGQVVSKCIYESAISNARRQNVKAKFTRSFLAQLLGLRVNYKYLESDDKDLYRSKVQLIEKNDPADLELKFTEEEYNSSGQLEKVVELLPGGRLIDVTEQNKCEYLNLMARYKLVESVQKEVEAFIQGLNELVPDNLLGMFDENELELLMCGTGHISVADMKAHHHVLAGGGQRFTKIMDWFWTIVSSLTQEELARLLQFVTGSSQLPPGGFAELSPQLQISYIATSQALPTAHTCFNQLCLPDFPSFNEMQRKLLLAVNEGCEGFGFS
65
B9I6Y8
3.1.1.11
ACT_SITE 198; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MQKPLFNAIVIILFITISSSNSQAIDCKPGRGKRVRKTIVVDHSGKGHFIKIQDAIDSIPINNDQWIKVRINPGTYIEQVTIPEDKPCIFLEGRDRTLTTITYNAHESTDTSATFTSSPSNIVAKGITFKNSYNLPFKQNINYGIKIPGVGVAPALSARIYGDKSAFYDCAFLGVQDTLWDVEGRHHFFNCYIEGAVDFIFGAGQSFYEGCSINVTSKGVITAQGREFPNDPSGFIFSGCTISGIEGVRAFLGRAYRPFSRVIFQDSYFSKVVDPLGWNAWGYAGQEENFTYVEVDCKGPGSNKSKRVPWVRKPSTGQHELFSKPSFIDQDGWLAKLPL
125
Q8ZEH0
4.2.1.20
ACT_SITE 49; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"
MERYQQLFKQLAAKKEGAFVPFVQLGDPSPAMSLNIIDTLIAAGADALELGIPFSDPLADGPTIQNAALRAFAAGVTPGICFEILAEIRQKHPTIPIGLLMYANLVFHNGIDHFYQRCAEVGVDSVLIADVPFEESAPFRAAALRHGIAPIFICPPNADDDLLREIASHGRGYTYLLSRAGVTGAENHGQLPLNHLVDKLREYNAAPALQGFGISEPAQVKASLAAGAAGAISGSAIVKIIEKNVAQPVEMLVQLTRFVTEMKAATRS
202
A0A1S4H697
3.1.3.1
ACT_SITE 143; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
MRDLARYFACFLAFALTAGELVTVPGAREPDGHSRRGKDGSFKSSAASSRTQTPQVQGFQERELETDYWLEQAQQTLAQKLATPHNTDHAKNVIFFIGDGMSSQTVAATRMYLGNEANFLSFENFKDLGSVRTYCVNRQVSDSSCTATAYLSGVKINYGMVNIAASVDRYACEYDRNASDFEGLLKWAQDAGKSTGIVTTTKITHATPAGAYASSANRYWENDVEVASSDCDPSRVDDIAEQLVDKEVAQRFNVVLGGGRGNLLPKETMDEEGKPGYREDGKNLIEQWKQTHETMGRSQYVWNREQLMSVDTANTDYLLGLFESGHMKYNLELKDNSEASRMEPTLEDMTRKAIELLQRNKNGYVLFVEGGLIDVAHHETWARLALDETAEMAKAIDTARKMTSEQDTLIVVSSDHSHTMTYNGYPKRGNDILGLGDISDEDLLPYTTLSYANGLSYYTTYTEENHAIRADPSNYDYKQTDMRYMAMVPMDAETHGGDDVGVWASGPMSHLFRGVYEQNTIPYLISYIAQIGDYYEESDSGAGQPLAVCLSLLLGCSIAALMRR
141
P73411
1.1.1.49
ACT_SITE 259; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00966"
MVTLLENPFRTGLRQERTPEPLILTIFGASGDLTQRKLVPAIYQMKRERRLPPELTVVGFARRDWSHDHFREQMRKGIEEFSTGIGSEDLWNEFAQGLFYCSGNMDDPESYLKLKNFLGELDEKRNTRGNRVFYLAVSPNFFPPGIKQLGAAGMLSDPVKSRIVIEKPFGRDLSSAQSLNRVVQSVCKENQVYRIDHYLGKETVQNLMVFRFANAIFEPLWNRQFVDHVQITVAETVGVEERAGYYESAGALRDMVQNHLMQLFCLTAMDPPNAIDADSIRNEKVKVLQATRLADINNLENAGIRGQYKAGWMGGKPVPGYREEPGVDPSSTTPTFAALKLMVDNWRWQGVPFYLRTGKRMPKKVSEIAIQFRQVPLLIFQSVAHQANPNVLSLRIQPNEGISLRFEAKMPGSELRTRTVDMDFSYGSSFGVAAADAYHRLLLDCMLGDQTLFTRADEVEEAWRVVTPVLSAWDAPSDPLSMPLYEAGTWEPAEAEWLINKDGRRWRRL
6
P55799
3.1.3.16
ACT_SITE 78; /note="Proton donor"; /evidence="ECO:0000250"
MPSTRYQKINAHHYRHIWVVGDIHGEYQLLQSRLHQLSFFPKIDLLISVGDNIDRGPESLDVLRLLNQPWFTSVKGNHEAMALEAFETGDGNMWLASGGDWFFDLNDSEQQEAIDLLLKFHHLPHIIEITNDNIKYAIAHADYPGSEYLFGKEIAESELLWPVDRVQKSLNGELQQINGADYFIFGHMMFDNIQTFANQIYIDTGSPNSGRLSFYKIK
144
F6TY81
3.2.1.35
ACT_SITE 148; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1"
MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPIIPNVPFLWAWNAPSEFCLGKFNEPLDMSLFTLMGSPRINITGQGVTIFYVDRLGYYPYIDLTTGVTVHGGIPQKVSLQDHLDKSKQDILFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLSLPQATDKAKQEFEKAGKDFMLETIKLGRSLRPNHLWGYYLFPDCYNHHYRKPGYNGSCFDVEIKRNDDLSWLWNESTALYPSIYLNTQQSVVVATLYVRNRVREAIRVSKIPDAKNPLPVFVYARLVFTDQVLKFLSREELVSTLGETVALGASGIVIWGSLSITRSMKSCLLLDTYMETILNPYIINVTLAAKMCSQVLCQEQGVCIRKDWNSSDYLHLNPDNFDIRLEKGGKFTVHGKPTVEDLEEFSEKFYCSCYTNLSCKEKADVKDTDAVDVCIADGVCIDASLKPPVETEGSPPIFYNTSSSTVSTTMFIWRLEVWDQGISRIGFF
166
F6HDK0
4.1.1.50
ACT_SITE 64; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 78; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 237; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 250; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MAVSGFEGFEKRLELHFSGDDPVVGMGLRHLDFESLEQVLHAVQCTVVSAVGNHYFDAYVLSESSLFVYPTKIIIKTCGTTQLLKSIPPLLHHGRHLGLAMCGCRYTRGSFIFPKAQPFPHTSFRDEVIYLEQSLPSTLCYRKASVMPSKMSSHSWHVFSASDEPHMVLQHMPDVLYTLEVCMTDLDRVLARKFFLRPGAGKAGDVAGKEMTELTGIGDINPGALICDFAFDPCGYSMNGIDGDRYSTIHVTPEDGYSYASFECVGSIYDDQNDVVQVLKKVVQVFRPATMSVSTTCTSHEVWTRVATALEPMGLKCRSCAVDEFPAAGSMVFQTFTTRRKEKRLVEVDM
196
A0A3B6ESG4
1.11.1.7
ACT_SITE 97; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MVCARTASAPLLAAALVAALAVACSLVSGAYAAAEQEAAGAGGNDLRLRQPPITRGLSFDFYKRSCPMAESIVRDFVRDAVRKDVGLAAGLLRLHFHNCFIQGCGRARVMHACRAATGPGEQRAPPNLTLRPSAFKAINDIRDRLERECRGAVVSCSDILTLAARDSVVATGGPEYRVPLGRHDSPRFATPQDVLSGLPATTSAVPSLLDVFHNHSLHLDATDLVALPGGHTVGLGHCVSFEVEFPQAVDPTMSPDFLGRLKRTCPAKGTDARTRDVRTPDVFDNKYYVNLVNREGFFVSDQDLFTNEATRPIVERFARSQRYFFNQFGVSMVKMGQIRVLTGDQGQVRRNCSARNPGSADGNLGLQWSSLVQTVVDAAAESLGF
14
A0A022RI95
1.11.1.7
ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAALTNSHAVVIIGLLLSCFILFVSAADDNSTAALTVGFYKNSCPFAEIIVRKYVNKFVTFNPGFAAGLIRLHFHDCFVRGCDASVLLDGKNSEKQSIPNKGSLRGFEIIDAAKAELEVKCPGIVSCADILAFSARDSAWKAGNIFYEVPAGRRDGNVSNTLDPLLNLPPPFFNATQLRDNFARKGLTLDEMVTLSGAHSIGIAHCTSFLGRLYPTVDPTLDPKYAAKLKKICPAPVANATGPPKVNPTVNQDTITPIRLDNLYYLGLKQKKGLFTSDQDLMTSPLTSNIVLNNIQFGGVWATKFAAAMVKMGNIDVLTGVQGEVREHCRHIN
14
Q8Y4G7
5.1.3.3
ACT_SITE 182; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 317; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MIFIEVMKERFGEFEGETVWKWTMINDHDMRMSVLNYGAIVTSLETKDKFGDFANISLGFTNLDDYLAHSPYFGATLGPVAGRITNGQFSLDGKQFQLIQNEGSNHRHGGKFNFSKKLWDVSVEKSLDQIVMTFEYCWADGENGYPGKIDAKMTYTLNNKNEWLVDYEARSNQPTIYNPSNHIYFNLSGEAGSTVLQHQLWVNSDSFLPIDEEFLPIGEKRLAENTIFDLRAGREVAEITQSQDQQVKLVGAGLDHTFILKHENGRPDAVLFDPKSGRRLEMETKADSVLIYTANSLDGSFEIDERAVPKYAGITMETQGLVDAINHEGFGDIVLRPEKPFTSRTAFRFTVES
211
A0A0K9NVI2
3.1.1.11
ACT_SITE 403; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MKSAKLTILAATVAFLLLLGVIVVCAIQYKSGESEDKKKDNEEASEIRLHAQSKQVKEMCSVTEYDHVCVVSLSNILKQTNLSNPQTKDLMRGAVIVVSDEISKVWMKSKLIKSDDPNVKGAVQDCEGLFRHAKKELLSSIQAMNIQGIEELPKKSPEIKNWLSAVLSYQQTCVDGFPDGTIKNKMQNIVKLSKELTCNALAIIDKVSSILEDLNLSDVVNSPTQRTTTGRVLPEWLDGDDRRFLMGRHTKKMKPNITVAQDGSGNFTTIVDAIAAIPYEHEGRICVYIKRGIYTESPILMAPNVTFYGDGSRKTIITGSKNFVDGVRTFHTATFAVDGDGFMAIGIGFRNTAGAVKLQAVALRVQSDRAIFLNCHMDGYQDTLYAQTHRQFYRGCVISGTIDFIFGDASAVFQNSVLRIRKPLENQQNIVTAHGRMDNHESTGFVIQNCKFVAVKGVEIDPKKISYLGRPWRECSRTIIMESDIGDFVNPDGYLPWDGSFGLKTLFYGEYNNSGAGAKLNQRVRWPGFKVITKEEAERFTAGEFIQGRDWIQQSGVPARFGLYHD
125
A0A061GWC4
3.4.19.12
ACT_SITE 18; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 128; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 143; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"
MASEQNQIYHERQRLQYCLLHSLNNLFQQKDAFTRASLNSVAEKLVLDDPNKEIWTPFSLVFKPHHNSITGNYDINVLIAALEGKGKTVIWHDRRNGASAIDLNDEILMGIVINVPVRRYAGLWKSRHWIALRNIDGVWYNLDSDLDAPQCFKDSGEVKDFLDYIITHDGQLLLVKNDRQVCKRKESILQIESLVRKVTQGSNKVSRKKGNNKVNASAMQKSDNKAAGNRGVTRSCGFMLCKRSKFSPVRFLKHLGGKVAKGLHVVSMRIRPSPKVSSSSGRSKPFVTPVDSHRSAAIEDCIEFINSSASLPRSNSVSANSH
175
A8WNQ8
2.3.2.26
ACT_SITE 996; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MSFNLVFFNGDVRRDKKQEAMLNSMVRRGKSRKMKNLAEKIEKNIQNLKIFERKFGTLNENFRLNARGNFLQSLADMEKQRTKNEEQTKAVRKIQKKWRGFRARHFLRLQFRAQFDAISDGHRGLENSNYLNFQKILQMAQLLVNFYETNKDEERLVMTLVELVKARTANRAFEQQIRDSQRFLLARCCVKFLDHADENTIFFHVFRFLEDFVTCHSHLYEAISQHGLFDAEFHLLEALIGKPEDVSIQKKPILPRHLQLLTRIFDVFVFQNPARTTPVSVHVADRLLKTICVKISDLNFANYILYYIRDHIRLSGTQHVNPNSSVIYEAGKSANVIQKWKLRPEEVETASIRLRAVFLSFVENVNKTNSESLKQLFDSLALVLDQHATIMKTLNVKEDLTENGRLRTAVNQYIWEYSNGILSSVNFRRAACAYANTQNVNVTSLIPMRKHFTECMDLLASSDTFLEALYTFITSSERFEPDDCCTQRINALELFCNCLNKRISSVADSDFIPTSIFPHFDATVEFVRDVSIKLIHSMFPVYQRGEPGVVRNQFKDVTDAVFSFLGAIYQKDIRLKYFPEGFWTNHGREVFVGIGHQARTTPRNRRQQPMRSEFVERLAELYEEEGGDSDDEELMERNAREKVPTALQRGICIMKNIPFIVPFMDRVQLFNRLVSQEHDRFMDVSRMFNNYNTNLTVRRDQIYMDAFEKYKPKAVKDDVRELKANIRVKMINWAGSNEQGVDGGGIFREFLSELLKDAFSVNRGFFTETTESKLLYPNPTAIYLLGADCLTHYQFIGRMIGKLIYERQLQEVRFAEFFIAQLFEDRTKDVDLQHMKSFDPLIFKNLKALQTTSEQELDELQLDFSVVTSDVGLVRTVNLKPNGSNQRVTVDNVHEYIRLYVNYYLKQRIATMVGAIRRGISEVVNIEWMSMFAPHELQILIAGFEEVFTIKELQQNCQITFGMASSTTDQDFIEMIWDVIDKLSKDDKMAFLSATCMNLLRIPKYSNRTKLEEKLRYAINSGAGFELA
65
A9V4T8
2.3.1.48
ACT_SITE 678; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
MGQRRMAAVAVMVVLLAGLQPAVMDIVTTLTTTTINNLKCQCTNASLFSPNEQIAACRKAKLIETVDTLINATFETRLAALEAVAFGDGCEPDAYSGTSPIVLTTNPPPLNLTLCDAETDMFEYTLPESGVYEVYLSPIDDVVSCIMPFVKVSFLLNNMPIQFDNMTTDGVKVTFTSPDPVSGTIKFLIESNQTVPCACALPLCLLIHSSIPLSVSLSLSLSLSLSLSLYFSFSNRPNQFISLSLSLSLSLSLSLSLSLSLSLSLSLFCDRYNPRKPIARAWKCIRCKTCMRCHKKGNADQLLFCDGCDAAIHTYCCRPKLNGVPDSDFYCPNCQGAPSASTDKSEQAKPGRTSKRQSGAQESSQPTQARDKRGSTIHTWLSPKPTNPSTPSPPSTGRTPTRTSTRGRGRGRAQSRTRATDRGRGTPGHATAHDEPSSATASAENRRKKTKHKSRARLNPLRGLDVPKAEANLFQRAFSQAQAVLNRTPLSTMGRLSVEIGDHRIKAWYPGAYPHEYATLSDIYLCEYCLRYFPAREQVGRHMDKCECLGHPPGTEIYREPERYDARGQRLAQLQLWEVDGHAAKLYCQNVCLLAKLFLEHKTLYYDVEPFLFYILTVADERGCHFLGYFSKEKHCLKKYNVSCILTLPCFQRMGYGRYLIDMSYLLTRVEHTVGSPEKPLSWLGARTYEAYWLRVLQEYLVSHNEVSLDDVSRKTGMTMADITSTMAKHGYIKRIDDSVKLVVDRQALGAELSAKTARRPICKRTAPRVSDRQREDLKARDRGGSRMDSNQGSADVPISCALVVLT
61
A0A251VH87
1.11.1.7
ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MATHKLLCNLSFIFLLFFQFHFGTSEIRLNYYSETCPNAEEIIKEQVISLYNKHGNTAVSWIRTLFHDCMVKSCDASLLLESINGIQSEKISSRNMGMRNFKYINTIKDAVESACPLTVSCADIVALSARDGAVMLGGPCIEMKTGRKDSKESHLAEIDASLPNHNDSMMYVLARFQSIGIDVEGTVALLGAHSVGRVHCVNIVDRLYPTVDPTLDPNYAEYLKGRCPHPDPDPIAVEYARNDRDTPMILDNSYYKNLMNHKGLLTVDQELVSNPITSPFVEKMAADNDYFHEQFSKALLILSENNPLSEEEGEVRTDCRFVNKD
14
P00334
1.1.1.1
ACT_SITE 153; /note="Proton acceptor"; /evidence="ECO:0000269|PubMed:15581900"
MSFTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAINPKVTVTFYPYDVTVPIAETTKLLKTIFAQLKTVDVLINGAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAHPTQPSLACAENFVKAIELNQNGAIWKLDLGTLEAIQWTKHWDSGI
1
F5HB11
2.7.11.1
ACT_SITE 311; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 328; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"
MASQPELTSTTAATDNQNVDLSNTTAQLNNLAIEEEDDDDDLQDVFESDDDLDYEDGGTDLTKSYNRQQHGAGATNSQQSQAQAQQQKPTANTSARVDDQIAALSKFAGKIRIDAFDNASGPAERSKDKSDRATSELVLDQRTRMILLQMINQGFVSEIHGAISTGKEANVYGAILHPEDGSAPIHKAIKIYKTAILVFKDREKYITGEHRFKSGSEKGNNRKMVKLWAEKEFRNLRRLYTAGIPCPEPIKLKLHVLVMSFLGDRKGWAYPRLRDAPISGDDADEQWRDLYIQLLGLMRKLYQVCRLVHADLSEYNILYNNKKLYIIDVSQSVEHDHPHSLEFLRMDIKNVGDFFRRKGVDTLSDRTIFDFIVNPKGPAEEPGMKETVEQLYQTRVEVEDTAEARAEQEVDNEVFRNQYIPKTLNEVYDIEKDVAKVNEGQGEDLVYKNLLADQVVHKTAEDQEEEESDEEEEGSGDEEEGSDDEDDESRFEKGTPRGKRFIDKDEKKQHKAAVKEAKREKRKEKIPKAMKKKLVNSTSRRKH
99
A0CQX5
2.3.2.26
ACT_SITE 1144; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MTATFVDQINFEFISIAISNTTKHRIIRINEDNFVVDPILTLPINTACYFESNAKSYKLQGQLNNFLKQHEEFKEVFLIFDDELDNQVHRAADRIIAENLGINNFIKGYEQFISNRNQNSINSQLQMYFGVQSISSIKISITKNLINKIEFIFAPLKHEGETLIKLKDQTLQVYSLLGENNIIYPEIDEVSFFFYNLIINFRDHHLESQITNDNQIQINFKRQPDLEFIYAFVDITLIAQYIHKLVCIIDKENEIKAINIQHTDEITTNNKYSLYSFVDDMIIFNYCKYYEFMFSNFILDYLNRKQINQIYKINQNITYSGPQILETKLDLTSRAIFSGLNQTDQVELLSIIDMNMTIHNQDKANPLEFKELILIPKVDGFYINLFYIKSFQHPALAKYNNQRQSQYQVGDEVHFLLHPINSSLSLDQQLQKLQVKLSLGQMEQKKYNLSQLLFQTSDLEHLIANCLFLSNNFVLVTIKSDSRLKINIYSTSSITLSQQNYQFSRQLNFEYLISTAQDLEKTIHVSVTHDEKTVKVKLEKDDHTTYGKGHKQLMEILLKEAKRNKKEIYQSVESTTHSSKLQSGNTINMLSNQDIAVATRAGVLRKDYIEFRDSNCNLVEQFTCGKVSFVHSIFNQIQYVPEKERAEEGLNLIWIPTFKGIYHLFIDNVKIEGRFIILANVPDLEISVIEIQSKFEVIPFCETILIQFYLKDKFENCYGDTENQIYSESNCDIKQVSGSQSISNLTFYNLTKDGNLNVNLTFDPIDLFVFNDTAEVEFFINNQLKTSQIWNLSGLGLNKRIQRFQEVINQVWKPTSYNLNISRVNFLEDLLELAEKKLNYQFSIKFQNEAGIDAGGLKREFYDMIGNVLKDEKFKFFSPVSSDQNKYFLHQKFNKQKNKERYALLFGKLIANSICNSYLIGIDIIAPFWKVVFNERIVFNDLNLIWDLDTYNNYEKLKTMSEEELKSVCLLFTYSSDNTETELIAEGSKIHVTQENLELYLNKTAEYVIHKQFDKIYKSFIEGFQSVLDISVSYCEYHLCICQKWLMNAEMFHFTQGFLEISSDVLLQKFTFSGGKPQHKSYFENYVNQADTETLKNMLKFITGNQYDNSLGSSSIPFDQSSYVISVKFDLGLSDRKLPLSHTCFKSIEVPLYKSFAELKQKFDIAFTIGCEGYGFG
65
A0A0P0X9S3
1.11.1.7
ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
LRRSTMAAARVAMWVACVLAMAAACQGRLRVGYYKRKCAPAEYVVRAVVGNAVRQNPGVGAGIVRMFFHDCFVQGCDASVLLDPTAANPQPEKLGPPNFPSLRGFEVIDAAKAAVEKACPGVVSCADIIAFAARDASFFLSGGGISYRIPAGRLDGRVSLANETLAFLPPPVFNLTQLVASFQAKGLDADDMVTLSGAHTIGRSHCSSFADRLSPPSDMDPGLAAALRSKCPASPNFTDDPTVAQDAVTPDRMDRQYYRNVLDRKVLFDSDAALLASRPTAAMVARNAAARGRWERRFARAMVKMGGIEVKTAANGEIRRMCRVVNE
14
A0A3B6H2L0
1.11.1.7
ACT_SITE 97; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MVCAWTASAPLLAAAVVAALAMVCSLGSGSYAAAEQEAAGAGGSDLRLRQPPIRRGLSFDFYKRSCPRAESIVRHFVRDAVRKDIGLAAGLLRLHFHDCFVQGCDASVLLDGSATGPGEQQAPPNLTLRPSAFKAINDILALAARDSVVATGGPEYRVPLGRRDSPRLATPQDVLSGLPAPTSAVPSLLDVFHNHSADLDATDLVALSGAHTVGLGHCASFEGRLFPRPDPTMSPDFLGRLRRTCPAKGTDARTALDVRTPDVFDNKYYVNLVNREGLLVSDQDLFTNDATRPIVERFARSQRYFFHQFGVSMVKMGQIRVLTGGQGQVRRNCSARNPGTTDDGLGWSSLVQTVVDAAAESYSTS
14
P53349
2.7.11.25
ACT_SITE 1350; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MAAAAGDRASSSGFPGAAAASPEAGGGGGGGGALQGSGAPAAGAAGLLREPGSAGRERADWRRRQLRKVRSVELDQLPEQPLFLAAASPPCPSTSPSPEPADAAAGASRFQPAAGPPPPGAASRCGSHSAELAAARDSGARSPAGAEPPSAAAPSGREMENKETLKGLHKMEDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEVNNLAAEPQGEGQAGSAAPAPKGRRSPSPGSSPSGRSVKPESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCGRGAFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVESPASLRAVQQPSSPQQPVAGSQRRNQESSFNLTHFGTQQIPSAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGGSGGSLSAGAASGSSQPSISGDVVEACCSVLSIVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTILVKCADANSRTSQLSISTVLELCKGQAGELAVGREILKAGSIGVGGVDYVLSCILGNQAESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTAVPAVFSKLVTMLNASGSTHFTRMRRRLMAIADEVEIAEVIQLGVEDTVDGHQDSLQAVAPTSCLENSSLEHTVHREKTGKGLSATRLSASSEDISDRLAGVSVGLPSSTTTEQPKPAVQTKGRPHSQCLNSSPLSHAQLMFPAPSAPCSSAPSVPDISKHRPQAFVPCKIPSASPQTQRKFSLQFQRNCSEHRDSDQLSPVFTQSRPPPSSNIHRPKPSRPVPGSTSKLGDATKSSMTLDLGSASRCDDSFGGGGNSGNAVIPSDETVFTPVEDKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDAEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMGHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVAVRCLELQPQDRPPSRELLKHPVFRTTW
105
P0DO50
4.2.1.1
ACT_SITE 98; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01134"
MKMINSIFTHGSLIILLLLFHSISIKAQEVDDEREFDYLEGSELGPEKWGELRPEWGTCKRGKMQSPIDISNPVQVTSKELLQTKYKAQNAIINNRGHDIMVRWEGDAGSILINEREFDLLQAHWHAPSEHAINGTRYAMELHMLHRSTDPKLTPTMVVVAVFYEIGDVDPFLSRLGPIMSSLIDQTNEHKQAGVINPMEIQLDDECYYKYIGSLTTPSCTEGVTWIINKRINTVSSDQVKLLREAVHDHAKNNARPLQALNHREVQLHCHKDRKD
199
A0A7M7RAI1
2.3.2.26
ACT_SITE 752; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MAVSMAGQICAACETTFSQGLQSQRVACPSCGRKLVGRVAAPMHPMQATRDRGNSGASLPPLSNPSSPTNEEHARSKFSGISNFFSNLGTKEKGKSAEKRSKEKLPRITPGQAMVSQNGARKIHTPDTQVAPGFKPITLQEFKSDVEKSKATKDTKILLKYFESTFLSFAHINVTFKDPVKNGKSLEDCGLVQEYIDSVYKCLLETTVEIQKITLKGIINSLLKDLKKPRDKNDLRAYLVLIQNPQFDKTSTFVIFAHLLRQLSTLADNDHHYMVHWFKGLPAANFKSIVERLQQFTSVRLFPPKSNELPPVGKCSWWIPSATKVLALLNASNSMCKPLKVPYTCFYNNTLDNIDLMKEYHAWQNPVGNQQIFTFCQYPFVLSLQAKRNIMQKDSEQQMIMTARRTLVAKVQQREMPNMNMLFLNLKVRRSHLVSDSLHEVANKKQDLKKKLRVTFAGEPGLDMGGLTKEWFLLLLRKVFREEYGMFTYFKKTHCFWFNPACTDCNQEFNLVGVLMGLAVYNSIILDIRFPAITYKKLLSPAVVPYNKPQASVGRCKVTMEDLEQVNPDLCHGLKELLKYDGDVEEDLCTTFQCSLPVYGTVMTYDLKPNGGDILVTNKNRREYVELYVNFLMNNSVYEQFAAFYHGFHSVCASNALIMLRPEEVEMLVCGSPVVDYEELEKVTLYDGFDKDDVTIKYFWEVAKGYPLPLQKKLLLFATGSDRVPIGGMGEMSFKIIRVDTSSNMLPMSHTCFNQLILPPYKSKRQLKQKLTIAISNAEGFGLE
65
B8DZY1
2.7.6.1
ACT_SITE 194; /evidence="ECO:0000256|HAMAP-Rule:MF_00583"
MGQRCLALYSGTSNRELAEEVAKYLGIELGEIEIRRFSDGEIYARIAKSVRGAEVYVIQSLGSKVNEYFMELLIIIDALKRASADEVTAVIPYYAYARQDRKTKSREPISAKLIANLLTVAGASRVVTMDLHAGQIQGFFDIPVDNLSALPLFTRYFQDKNLKNPVVVSPDIGGVTRARALADRLHTPLAIIYKRRPAPEVAEVEEIIGEVEGRDVIICDDIVTTGNTLFSAAKLLKLKGARDIYAAVTHGILTNDAHKKLQESEIKELVVTNTIPIPLEKRVPKLTIISIGNLLGEAIKRISNKDSLSSLFD
114
A0A1S3Y597
2.3.1.181
ACT_SITE 186; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1"
MTDCSMIYRRMRRSVEVWKMGTVNYLEALKLQEKLASDRKALKITDTLLSLQHPPTYTLGKRQTVHNLLIPDSELKAMGVELHYTQRGGDITFHGPHQAILYPIVSLRDIGLGARTYVEKLELTMIELASIYGVKAQVGKRCETGVWVEDRKIGAIGVRISSGITSHGLAFNMDPDLNYFKHIVPCGIADKDVTSLKKEADVELPAEEVIQEQLIACFVRIFGYNDVILKDKSVL
55
D2A3C2
3.1.3.1
ACT_SITE 127; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
MFVAITVLCLLVPSQLAAVIKNENLFQYINPTPDNELLREDKQFWYDVGNNYLEKNLRYDHESTTKVAKNVVILIGDGMGISTITATRIYKGQRSGKSGEDHTLAYDNFPNVALVKTYNVDMQVPDSAGTATALFTGVKTRYEAVGVDVNCNKTIADRTVFEASKLEGIMTWAQQANKSTGIVTTTRITHATPASTYAHAHYREWECDSEMPQEFKPFVKDIARQLVEDAPGNNFKVILGGGYQQMGHIFEDLSDGECVRNDTLNLTQTWIDDHKGLKASFVTNNQQLENVGDVDYLLGLFYPDHLPYELLRNKGLDGTPSLSQMTKKGLDILQKNPNGFVLMVEGGRIDHGHHDNYARLALEEASEFEKTVALIVETCGPETLILVTADHSHAMTLNGYSRRGNDILGYGLETEDDKPALTLTYANGPGFAYHFSPNVSTVLGPWRDVREDWNRLNNPKYQQMASFELDDETHGGEDVAIFGTGPGSHLVRGVVEQNYVAHLISYAACIGPRAGINPRCAKNLDVSLVGNFYLLFSMLFFLNKL
141
U5CPU8
3.1.1.11
ACT_SITE 240; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MENLMRILILILLLCFGLEQGQAKSLRKLQPPKILINFPENGTKNQLIEDQFMMWVEWVGSLKHSLFGAAINKIFPSFYLTVDKNPAKGDFTTIQSAIDSLPFINLVRVVIKVNPGTYTEKVIIPAMKAFITIEGAGADRTEVQWGDTAQTVGPTGQPIGTFNSATFAVNSPYFIAKNITFKNTTPVPKPGASGKQAVAFRISADTAAFLGCKFLGAQDTLYDHVGRHYYKDCYIEGSVDFIFGNGLSLYEGCHVHAIANNYGALTAQNRMSLLEDTGFSFVNCKVTGSGALYLGRAWGAFSRVVFAYTYMDNIIIPRGWYNWGDPNREMTVFYGQYKCAGPGASFAGRVSWSRELTDEEAKPFISLSFIDGSEWIKFL
125
P30290
2.7.11.1
ACT_SITE 417; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MDSSTTIPITPTRTPCFFNISSSFNEHSPLNFYDEPIYNFSSGHEENQSHKSSKLTFFKPSNTKRSPHTPMQNNAKAIRLSTTVRHGIFKNSDLDGCSKPFAFSSGLKLSKKIVDASTPIDLKRKRAVTSLSTGLLSKREKWSLWEGNLTNPRSEQPHTPCKKGTKIKLKPPQSPLSPTTSLLARKCKHIDLDTFSRLDHPNSDSSDETFEMEELPSLSYGSEDLLEFCETPCKSQPIFLSSSHVNNWDEKDVPSSLSWTPTSPIFLNINSADDYEEEEDWTSDLRIRFQQVKPIHESDFSFVYHVSSINPPTETVYVVKMLKKNAAKFTGKERHLQEVSILQRLQACPFVVNLVNVWSYNDNIFLQLDYCENGDLSLFLSELGLLQVMDPFRVWKMLFQLTQALNFIHLLEFVHLDVKPSNVLITRDGNLKLGDFGLATSLPVSSMVDLEGDRVYIAPEILASHNYGKPADVYSLGLSMIEAATNVVLPENGVEWQRLRSGDYSNLPNLKDLLLSKEKVQINKVRCAESLQCLLQRMTHPYVDCRPTTQDLLAMPEMIFISEHSQKAAIIYEDHNSWLET
99
A0A6P9E9T8
2.3.2.26
ACT_SITE 1496; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MGNRGQKRAEMVDELPADKRACSSLDFRPSSSNSSVQTHMNSPNSAHETRDNDMETSSSASASSRSEGEPERDSAYGSCDSDDAEQRHSNLRHYRDYQRQRSSTDHGKFKRILSSLSEETGPSEQLASLTELCEVLSFCTQDSLSSMVSDSLSPLLVNLAKHESNPDIMLLAIRAITYICDVYPRSSNFLIRHDAVPALCQRLLAIEYLDVAEQCLQALEKISREQPLACLQAGAIMAVLNYIDFFSTSVQRVALSTVVNVCKKLPSECPSSFMKAIPILCNLLQYEDRQLVEYVAICLIKIVERVSQSSELLDELCKHRLIDQVIHLIDLNCRTTISRPIYNGLIGLLVKLSSGSIVAIRTLYELKISSILKDILSTYDLSHGMSSPHMVDGHCDQVYEVLKLLNELLPTTARDQDNQQVLDKESFLVNSPSLLQKFGLDILPLLIQVVNSGANLYVCYGCLSVINKLVYFSKSDMLLELLKNTNISSFLAGVFTRKDQHVLLVALQIAEMILQKLSDIFLSSFIKEGVLFAIDALSVQENCAQLMFPKFTGVQLSFDSSQKSASKEVPSCLCYAFATGQSLTTSETCSCKLENDSVHKLAKHIKTNYFTPNLSEQGVTDILQKLRTCSTALSDLVNATIGNDAPAQHEGRFYCIVHQIMETLNGKEPISTFEFIESGVVRSLLSYLSNGQYLREKGKAQGVNGHLIIVEKRFEMFARLFLSSSEPYSVDLPLLVLIRKLQSALSSLENFPVILSHGSKQRYSYAMVPIGRRTMHPCLKVRFVRGEGETCLGEYSGDVQTVDPFSSLDGIEGFLWPKVSIRRNEHIKSASCTMGKTESLPHELPSTDNDANLSQSAFEQALNEFAKQEMQLPLEADVNMEVQHPASCSDEDALQKLVFYLEGQQLDHTLTLYQAILQKQIKENEFITGAKLWSQVYTLTYKRALEPIQGNSQECLQSGQNLSVSDKVGAYMQYTPFVSSIYACELTSDLERSSSTYDVLFLLKSMESLHRFTFHLMSRERICAFAEGRIDNLDSLKVGVPSMPHNEFVSSKLTEKLEQQMRDSLSVSIGGMPCWCKQLVASCPFLFSFEARCKYFQLAAFGQLQAQSHQLSHSNSGATSDRRPGSGSLPRKKFLVFRDQILESAAKIMDLHARYKMPVEIEYNQEVGTGLGPTLEFYTLVSREFQKSGLGMWRGEYGLFASRTSLEAEDMGILMSPSGLFPRPWPSTLSTTDDQFLEVIKKFVLLGQVAAKSLQDGRVLDLHFSKAFYKIILGRELTLYDIQSFDPELSRTLLEFQALVNRKKFLESVNGENSPAEFDSCFRDTRIEDLCLDFTLPGYPNYVLASGPDYKMVNMRNLEDYVSLIVDTTINTGISRQSEAFKSGFNQVFPIEHLQIFTEEELEHLLCGEHDSLVFNELLDHVKFDHGYTASSLPIVNLLEIIQEFDHGQRRAFLQFVTGAPRLPPGGLASLNPKLTVVRKHSSICADTDLPSVMTCANYLKLPAYSSKERMKERLLYAITEGQGSFHLS
65
A0A8M3BCL4
2.7.10.1
ACT_SITE 831; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
MKLASSLCCLGFLLTSVAVRLSDSQQVCTGTENKLSTLSDLDQQYRTLRKYYENCEVVMGNLEITSIDRSRDLSFLRSIREVTGYVLVALNQFEYLPLENLRIIRGTRLYEDRYALAIFLNYRRDGNFGLRQLGLKNLTEILNGGVYVDQNKFLCHADTIHWQDIVKNARPDHLVVPSNSSSSCQRCHRACNGRCWGPKEDQCQSLTKTVCAEQCDGRCFGPYVSDCCHPECAGGCSGPKNTDCFACTNFNDSGACVTQCPRPFVYNPTTFQLEHNPWAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENRIKMCIPCTDICPKACDGIGTASLQTAQTVDSSNIDRFINCTKINGNLVFLITGIKGDVYHNIEPLDPEKLNVFRTVREITGFLNIQSWPENMTDLSVFSNLATIGGRALYSGISLLVLKQQWITSMQLQSLREISAGNVYVTNNSQLCYYNTVNWTRLFRINTQKALIRNNRDPKECILDRMVCDPLCSDAGCWGPGPDQCLSCRFFIRGRTCVESCNLHEGDVREFANGSVCLECDAQCEVPEDDALTCTGPGPDHCVKCRHFKDGPNCVEKCPDGLQGASSFIFKYAEANNECHPCHVNCTQGCTGPRLQDCIGVMDRTPLIAAGVIGGLFVVIIIGLSVAISVRRKSIKKKRALRRFLETELVEPLTPSGAAPNQAQLRILKETELKRVKILGAGAFGTVYKGIWVPEGETVKIPVAIKILNEATGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDANEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQSLLDEEELEDLMDAEEYLVPQAYSIPPLAYTTRSRMDPNRNQFAYQDGSFGMEDMMATIPRVVAVSAVSPGCSTQKQSKGQQGASGSSEAFEDSRCNGTLRKKASPRASTGDDSSGQRYSADPTVILCEHGARAETDQDGYMSAMQDKKPSDFLNPVEENPFVTHRRNGEVHTLERGYHSTSNGQPKLEDEYVNDPLYLNTFHNTGEKSHDALRKNGVPVVHTAAAAAATVAAANTITANNHTLSQTMQPAASSAHITTQPLYQGKPSISTLSGHTLHSAHPGHALHPTHTLHPAHTGTIKADLKAKKTFDSPEYWQHSLPPKATLHNPEYLQDCSTRFFYRQNGRIRPAVAENQEYLSDYALKPGTVLPPPPYRQRNTVV
97
P44334
1.1.1.205
ACT_SITE 306; /note="Thioimidate intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01964"; ACT_SITE 402; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01964"
MSLRIKQEALTFDDVLLVPAHSTVLPNTANLSTQLTKEIRLNIPMLSAAMDTVTETKLAISLAQEGGIGFIHKNMTIERQADRVRKVKKFESGIVSEPVTVLPNLTLAELAEMVKKNGFAGYPVVDGENNLIGIITGRDTRFVKDLSKTVSQVMTKKEDLVTVKEGASREEILELMHQHRVEKVLVVNDSFKLKGMITVKDFQKAEQKPNACKDEFGRLRVGAAVGAGAGNEERIDALVKAGVDVLLIDSSHGHSEGVLQRVRETRAKYPNLPIVAGNVATAEGAIALADAGASAVKVGIGPGSICTTRIVTGVGVPQITAIADAAAALKDRGIPVIADGGIRFSGDIAKAIAAGASCVMVGSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMAKGSSDRYFQSDNAADKLVPEGIEGRIPYKGYLKEIIHQQMGGLRSCMGLTGCATIDELRTKAEFVRISGAGIKESHVHDVAITKEAPNYRMG
3
A0A2R6W6I4
2.3.2.26
ACT_SITE 1005; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MDFFSGDPSSRRKVDLGGRSNKERDREKLLVEARLEREQRKLVRLHNQSAAQIQKCFRGRKVVAVARPAIRSEFCSQFGEFGEKADSTVFRSSSKYFPQLFFFFNEKDAGDCQRLVQACRLLQQSLRETGDVVALFTENDQIDGPLVIYRVKRLARICLQTLHVHRNSLKAELLQPVQAFNSLTNSATLLLDTVLTLTGDNFPWSEVVLKYLHEYKLFYLLRSIFLMVEPEEKPTKMTCIESAVLVFASRHVRSLRSDTSKLTKGSFSTDILSIPLVWKRFPIFKQECIKEKVWAHSVHQIAASLSELLSILPPDTCPGFPSSVCLLGNLLEIAAAAMRGPDCELKLASDFALVTRYLMERLPASFYKFVKALDEGYEDEMDVDGFGKVTMPEPELKEQLKYAEDYELLKTLVRVTCSSSATSTTEAPSSTEAAAVGAVCAFLYATFTVLPSNLVMTGLAYRAELVPQLWQYIKRCHLAHSWPSLELVGDASDSQVPADLLGWMLPLAVFCPVFSYLLTTIDNEEFYEQQRPLSLEDLVQLVTILKEALWQLLWVMSAKPPSIVSNQRLGQTLQNRMFSSKAIRDRVADVSASLLAALHDRNSRRQFSPPQHFHAREAVDENFFAQAEGENTRAQYLLRKAPFLVPFTDRVRIYTSQLTAARQHSTHQTPFPRLRVRIRRDRIIEDAFAQLNPLAEEALRGTIRVTFVNELGVEEAGVDGGGIFKDFMENITKAAFDIQYGLFKETSDHLLYPNPASNMVHDDHLHYFEFLGKILGKAMFEGILVDIPFATFFLSKLRNKHNFLHDLPSLDPELYRSLLFLKHYSGDLSQLGLFFVIENNEYGEQMEIELLKDGKDMPVTNKNKINYIHLVANHRLNTQIRQQSSYFLRGFQQLIKMEWINMFNEQELQILISGSQEGMDVNDLRSNVHYAGGYSETHPVIEMFWDVVKTLDMDLQQKFLKFVTGCSRGPLLGFKYLEPRFCIQRAAPEDASEETLDRLPTSATCMNLLKLPPYRSKETIQEKLLYAITAGAGFDLS
65