Datasets:
tamarpeleg
/
EC_exercise

Dataset card Data Studio Files
xet
Community
1
Entry
stringlengths
6
10
EC_number
stringclasses
260 values
Active_site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
O67088
3.4.21.89
ACT_SITE 32; /evidence="ECO:0000250"; ACT_SITE 75; /evidence="ECO:0000250"
MRKQIVELFLIILAVLFIREYIAQAYTIPSASMEPTLLVGDFILVNKLVYSLSEPMRGDMIVFKYPKNPDIDFIKRIIARGGDTVEFFPYYDEKNNVLIYKVAVNGKLYELTYEGEKNYSYDCYQYREKLYREDGEVIQHSVCFRNTLLKVPGMVYNAISSDLCLKYNEDGFCVKFVVPEGYYFVMGDNRDNSQDSRFWGFVPRENIEGKAFVIYYSGKVPSLTPEEANPLTAVRQIIYALLNPRPSRIGKPLIDK
178
A0A1S4GZ32
3.1.3.48
ACT_SITE 532; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 534; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"
MVTLMPCSYISASRISIIDKMIEIEPKGKRSRLEGPDTTTERSRLYSNLADSSPLGAATTAVSATLDTIGAGPALALGTPFHYPPGALSAHHTTGSEHTVFNHAGTGTTSTTSTPYRASNTSGGSLSLHNGLTLSYGTLGSAASPVGSSLTSRLNNSAGSSGSSSSSSNSSSTVVSTGTVSSGGSSAGSSTAGLVDGLSTLATGSSSSSSLVGPLLTTGGGVATATATTAAAAELGMSHWLSDGTVKSELRSPGLDANHLAASATNLPLGPATAAHHLDGTGLFCANPGTTAVATAATLDALQSQSAAAAATNVYDHKSDYYNYYNSMQQYTPAFYSSAYGATAYGAARTASTKIPSPNTYLASPYAAAAAASNNNSAQLYSSYGYNGSFGQFGAGQQDGYSYYNDQYSPYYANTASYSPYVSSPGSSGSQAGFHVAAGLSADSPSEAHATTPNMLAHSHSPQSPISISPTAGIGALPGVGGGGGGISSKTTPTGKSGRARGRRHAHPSPTRSSTSEPGISEKAPERIFVWDLDETIIIFHSLLTGSYAGRYNKNRDHQVQLGYRMEELIFNMADAYFFFNDLEECDQIHIDDVASDDNGQDLNNYNFAADGFHTATPQGAPPNVCLPNGVRGGVDWMRKLAFRYRKIKDTYNTYRNNVGGLLGPQKRDHWLQVRSDIEHETDSWHSLTLKCLNMIAQRENCVNVLVTTTQLVPALAKILLYGLGQVFPVENVYSANKIGKEQCFERIVTRFGRKSTYVVVGDGQDEENAAKNLNFPFWRISSHSDIRSLHTALEMGFL
149
F7BZN6
3.2.1.23
ACT_SITE 174; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 254; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
GALTDSLWCLSLHTNRTFQIDYERDQFLKDGKPFRYISGSIHYSRIPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPLPGVYRFSDDYDLEYFLQLAHEIGLLVILRPGPYICAEWDMGGLPAWLLTKKSIVLRSSDPDYLAETEKWLGVLLPKMKPYLYQNGGPIITVQVENEYGSYFTCDYNYLRFLQQLFHKHLGEEVVLFTTDGASEDYLKCGTLQGLYATVDFGTNHNITEAFQSQRKTEPKGPLVNSEFYTGWLDHWGEAHETVDTKAIISSLNDMLSQGANVNMYMFIGGTNFGFWNGANIPYAAQPTSYDYDAPLSEAGDLTEKYFALRELIGKFEKLPEGLIPPTTPKFAYGKVAMKKVNTLEESLDVLCPEGPINSTYPLTFIEVKQYFGFVLYRTTLPKNCSEPVPLSSPLNGVHDRAYVSVNGVPQGVLERNKVISINITGKAGDILDVLVENLGRINYGHDINDFKGLISNLTLGSVMLKDWSMFPLNLDAAVQNNLESHETWSNNPSSPSLPTFYVGQFSIPTGIPDLPQDTFIQFPNWNKGQVWINGFNLGRYWPARGPQVTLYVPRHILVTSSPNNITVLELEKSPCEDPRKCFVEMVDTPVLNVLPSSKKS
163
Q813Z9
5.4.99.12
ACT_SITE 53; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171"
MHNYKLTIQYDGARFKGWQRLGNNDNTIQGKIESVISEMVGKEIEIIGCSRTDAGVHALNQVANFQSDEKLVEHKVKKYLNQYLPNDISITNVEEVHDRFHARYNSKAKTYLYKIWNEEHTNPFMRKYSMHVNKKLNVKSMKAAAKHLVGSHDFTAFSNAKSKKKSMVREVYTLDVMEEAGFVQIRVSGNGFLHNMVRKIVGALIEVGLGQLDAEAIPNILEEKQRNQINCLAEASGLYLENVEF
217
Q2G0S2
2.7.6.1
ACT_SITE 202; /evidence="ECO:0000256|HAMAP-Rule:MF_00583"
MLNNEYKNSSLKIFSLKGNEALAQEVADQVGIELGKCSVKRFSDGEIQINIEESIRGCDVFIIQPTSYPVNLHLMELLIMIDACKRASAATINIVVPYYGYARQDRKARSREPITAKLVANLIETAGATRMIALDLHAPQIQGFFDIPIDHLMGVPILAKHFKDDPNINPEECVVVSPDHGGVTRARKLADILKTPIAIIDKRRPRPNVAEVMNIVGEIEGRTAIIIDDIIDTAGTITLAAQALKDKGAKEVYACCTHPVLSGPAKERIENSAIKELIVTNSIHLDEDRKPSNTKELSVAGLIAQAIIRVYERESVSVLFD
114
Q66GN2
2.7.11.1
ACT_SITE 491; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MGRAKSMVSLLLVLFLVRAHVATTETTTEFIFHGFKGNQSEIHMQGDSTITSNGLLRLTDRNSDVVGTAFYHKPVRLLDSNSTNTTVRSFSTSFIFIIPSSSTSNGGFGFTFTLSPTPNRTDADPEQYMGLLNERNDGNSSNHVFAVEFDTVQGFKDGTNRIGNHIGLNFNSLSSDVQEPVAYFNNNDSQKEEFQLVSGEPIQVFLDYHGPTKTLNLTVYPTRLGYKPRIPLISREVPKLSDIVVDEMFVGFTAATGRHGQSSAHYVMGWSFASGGEHPLAAMLDISQLPPPPPNKAKKRGYNGKVIALIVALSTVISIMLVLLFLFMMYKKRMQQEEILEDWEIDHPHRFRYRDLYKATEGFKENRVVGTGGFGIVYRGNIRSSSDQIAVKKITPNSMQGVREFVAEIESLGRLRHKNLVNLQGWCKHRNDLLLIYDYIPNGSLDSLLYSKPRRSGAVLSWNARFQIAKGIASGLLYLHEEWEQIVIHRDVKPSNVLIDSDMNPRLGDFGLARLYERGSQSCTTVVVGTIGYMAPELARNGNSSSASDVFAFGVLLLEIVSGRKPTDSGTFFIADWVMELQASGEILSAIDPRLGSGYDEGEARLALAVGLLCCHHKPESRPLMRMVLRYLNRDEDVPEIHDNWGYSDSSRTDLGSKLVGYISSDRASSSHSHTSSSLTRISSTSLISGR
99
Q4X262
2.7.11.1
ACT_SITE 243; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
MATKALEARFEHLSVKDDADHGRNGSTYSKHKGSLSTAVSLSGLGAAGQFNSGSSRSTLLKLALQNTNENKVNAMHTGSSPLKGAQSTLAHRDTDENGESRHTTPLYEQPGPKKLHLGMFEIGKPLGKGKFGRVYLAKERSSGFVCALKVLHKSELQQGGVQKQVRREIEIQSNLRHPNVLRLYGHFHDSKRIFLILEFAGRGELYKHLRKEHRFPEWKAAQYIAQMAAALKYLHKKHVMHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRQTMCGTLDYLPPEMLKPNPQDNYYSEKVDLWSLGVLTYEFLVGEAPFEDTPVMTQRRIARADMTVPSFVSPEAKDLIKRLLVLDPDKRISLDEIQRHPWILKHCLKDDRVTKQSSGSSKEVKA
99
A0A9R0IKM8
1.11.1.7
ACT_SITE 77; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAVSFSYGSYHFRLYVLPLGFVLMTLVSHFYAHDLRIGFYNGKCGGHNIEKFIYGVVKNKIVEDPNVVSDFIRLSFHDCFVRGCDGSILLEGKHTEKTARVNKRVGGIEDVGDIKKAVEKVCPRVVSCTDVLVITTRAAVFLGGGKWYDVETGRRDGRVSLSKEAEATLPPPTIPVHKAIQLFAKKGLNKRDFVVLLGGHTAGTAHCHSFKKRLYNFHNTHKPDQTISSPLLRVLRKMCPLHSQSDKEAFLDQTPNSHFKMDNGYYKQIVAHNGTLEIDQNMALSPLTRGIVKGLANSPYQFVNEFGPAMVKMARIGVLTGHHGVIRKTCGSVN
14
W1NL96
3.1.1.11
ACT_SITE 392; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MGSLVLHLPLRIAFLSTIFSLLTYQVHPVSLSNLSHPQLESLCKSTPFPSRCFDTLKLSVSINLPNILDLAKQTLQNALSEATKTTNLVMGLRQYGLVERERGTIQDCQELHQRTLDFLQSSLKIGNPKPENLNKIRTLLSAALTNKNTCFEGLDSASGSIKPTLMSKLNSMYELVSNSLSMYSNPSKSQGRQGRRLLEDSGRRKSGFPARFSRKRGFPAWLTGKDRRILQSSPGDGYDSGDILIVAKDGSGNYSSIMEAVNAMPNNRLDRFVIFVKEGVYEENVEIASNKQNLVMMGDGIDVTVITGSRSVGDGWTTFRSATVAVMGDGFLARDITFENTAGPEKHQAAALRVNADISAFFQCSFRGYQDSLYVHSLRQFYRECDIYGTIDFIFGNAAVVFQGCSIILRKPMEGQFNAITAQSRDIPDESTGMSIQNCTIEPDSDLASNPGSTKNYLGRPWRVYSRTVYLESYIDRLIDPAGWTKWSGDEGLDTLYYGEYSNYGPGSGTDNRVSWLGFHKMDYSDASNFTVSEFIDGDNWLVSTSFPYDDGI
125
Q24216
2.7.11.23
ACT_SITE 137; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1"
MLPNANDKTERYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENIIGLVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNFPGTPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVGPKLPMPSAILAAKEGANPQTGDTKPALKRKLVETTVRGNGLAQKKRLQF
103
W1PJK7
1.11.1.7
ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MDLQLFLLPFFFLSLVNAQLRFNFYNSTCPNAESIIKSAVTNRSNTDPSITAALLRMHFHDCFVRGCDASILIDSTTKHKSEKDAGANQSVRGFELIDEVKTALEKECSNIVSCADIVTIATRDAIALSGGPAYAVPTGRRDGRTSNPNEVNLPGPTLSVLQAFSFFQAKGFTLKEMVTLLGAHTVGVAHCLFFRDRLFNFRGTQKPDPSMDPDLVSKLQRQCGRNNLPIATDPTAFLDQNTNSTVDNEFYNQVLKGKGILLIDHNLGADNSTVGFVKQFGGDANGFLQDFKAVMVKMGSLNVLVGNAGEIRKNCRVFNATPKPSKGK
14
D7TAA8
1.11.1.7
ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MQSSTFRLAFLVVLISVLLSLRDPSKGEPQNHAIHGISPPKLDHQPSLEYDFYRNSCPKAESIVRSSMAQIFAAHSDTPPALLRLLFHDCFIQGCDASILLDDSNESTNRSAEKLAIPNQTLKGFDKVEKIKEELEKACPGVVSCADILVLATRDGIVLAGGPFYPVFTGRRDSNQSYFQEAMDDIPKPDGNITQTLGLFTLRGFNERETVSLLGGHSIGKISCEFIQGRLFNFSGTGQPDPSIASDFLDEMRRNCQDSGNSSNGTASPPMVSRAMSELTLGMTYYQGLSSSVSSGSAFDTHYYQSLLQGRGLLFSDQQLMAEEKTERLVRAYASDDGSTFQIDFARSMMKMSTLSVLTGSQGQVRLNCSKMVSS
14
P00929
4.2.1.20
ACT_SITE 49; /note="Proton acceptor"; ACT_SITE 60; /note="Proton acceptor"
MERYENLFAQLNDRREGAFVPFVTLGDPGIEQSLKIIDTLIDAGADALELGVPFSDPLADGPTIQNANLRAFAAGVTPAQCFEMLALIREKHPTIPIGLLMYANLVFNNGIDAFYARCEQVGVDSVLVADVPVEESAPFRQAALRHNIAPIFICPPNADDDLLRQVASYGRGYTYLLSRSGVTGAENRGALPLHHLIEKLKEYHAAPALQGFGISSPEQVSAAVRAGAAGAISGSAIVKIIEKNLASPKQMLAELRSFVSAMKAASRA
202
A0A3B6RBY9
2.1.1.33
ACT_SITE 181; /evidence="ECO:0000256|HAMAP-Rule:MF_03055"
MPNPDEAGGEPDAAPRGLGQMTRTSGANGGGQQGSGKLPRKRFYRARAHSNPLSDSHFPIPISPDDVDLSQHYPRYFPADKGEHGDGDGDAEAPRIRFADVGCGFGGLLVGLSPLFPDKLMIGMELRDKVTEYVKERVLALRASNPGQYDNISVVRTNSMKYIPNYFGKAQLSKMFFLFPDPHFKEKNHRRRVISMHLLDEYAYVMEAGGIIYTITDVEELGIWMRTCLEKHPLFGAVPEEEIKVDPVVKLLSSATEEGQKVARNGGQTFQAIFRRISLQEE
45
H2M5S7
2.7.10.1
ACT_SITE 783; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
MMGKDRRGVMPGCAWVVILVCVIPSVCAVEETVMDTRTATAELGWISFPANGWEEVSGYDENLNTIRTYQVCNVFEPSQNNWLLTTYIDRRAAQRIYVEIRFTVRDCASIPNVLGSCKETFNLYYLETDRRETAGNRGVEYWANAPFLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLSKGRGFHLAFQDLGACMSLLAVRVFYKKCPSIVQNFAYFPETLTGAESTSLVIARGSCIENAEEVDVPIKLYCNGDGEWMVPIGSCSCKAGYEPDSSNVCRACPQGTFKSSQGAGLCQQCPFNSRSTIEAATLCGCRNGYYRGDTEKPEDMCTSVPSAPRNLVSVVNQTSVRLEWHPPREIGHRDDLSYNVICRRCHSSERRTCQPCDDNVVFVPGKQGLKGTRVEISKLRAHMSYTFEIQAVNGVSNKSPYPAQQLSINITTNQAAPSVVPIMHQVSSTSRSFSLSWPAPEQPNGIILDYEVRYYDKSQSSLLNSSVVLSDTPNVVLEGLRPGTGYVVQVRARTVAGYGAYSKEMLFHTLTDDEYKSELGQQLTLIAGSLVGGVCIVSLVAVTIICTRRRQLKESVFGDKLQQYNTGGEGNLRPDMFSGPAPTVTFPTLSEGRGSPGVKIYIDPFTYEDPNEAVREFAKEIDPSCVKIEEVIGSGEFGEVYKGRLKPVGKKEILVAIKTLKVGYSERQRRDFLAEASIMGQFDQPNIIRLEGVVTKSRPTMIITEFMENGALDSFLRQNDGQFPVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRYLEEDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVTWEVMSYGERPYWDMSNQDVINAIEQDFRLPAPMDCPVVLHQLMLDCWQKDRNARPKFPDIVSMLDKMIRNPASLKAGSNNMPPGPPHHPLLDRGAPDLSRVSSVEDWLAALKMTQYRDSFIGSGFTSLPLVTQITAE
97
W1NKE3
4.1.1.17
ACT_SITE 365; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MGSDQLGAPSTRTLQAVISSPHIRNKRLWPLSKCSKGGVSDLVQTIIKKQDAKDPFYLMDMGSLASLWDRWQEVLPTVRPFYAVKCNPEPALLGAMAALGAGFDCASRAEIESVLAQGVSPDRIVYANPCKAETHIKYAASVGVNLTTYDSKDEVEKLRRLHPRCALLLRVKPPDDAGARCPLGPKYGALPEEVVPLLQAARSAGLSVTGVSFHVGSGAAHARAYTSAIAAARAVFDSARQLGLPSMRILNIGGGFTAGERFAEAAGFIRNALRSHFTDQVTVIAEPGRFFAETCFTLATNIIGKRVRGELREYWISDGIYGSMNCLLYDHATITALPLACASGRGNPNCVGMRNYPSTVFGPTCDALDTVLKGHHLPELYINDWLVFPNMGAYTASAGSSFNGFSTAAIPTYLACSSAT
195
A0A3B6C7J9
2.4.1.18
ACT_SITE 484; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 539; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"
MASPAFAVSAAGLARPSTPRSGGAERRGRGVELQSPSLLFGRNKGTRSPRAVSVGGSGWRVVMRAGGPSGEVMIPDGGSGGTPPSIDGPVQFDSDDLKVAFIDDEPSLQDEGEDSIWSSETNQVTEEIDVEGTNIMDKESSTGEKLRIVPPPGNGQQIYEIDPTLRDFKYHLEYRYSLYRRIRSDIDEHEGGMDVFSRGYEKFGFMRSAEGITYREWAPGADSAALVGDFNNWDPNADHMSKNDLGVWEIFLPNNADGSPPIPHGSRVKVRMDTPSGIKDSIPAWIKYSVQTPGDIPYNGIYYDPPEEEKYVFKHPQPKRPKSLRIYETHVGMSSPEPKINTYANFRDEVLPRIKRLGYNAVQIMAIQEHSYYGSFGYHVTNFFAPSSRFGSPEDLKSLIDRAHELGLVVLMDVVHSHASNNTLDGLNGFDGTDTHYFHGGSRGHHWMWDSRVFNYGNKEVIRFLLSNARWWLEEYKFDGFRFDGATSMMYTHHGLQVTFTGSYHEYFGFATDVDAVVYLMLVNDLIHGLYPEAVTIGEDVSGMPTFALPVQVGGVGFDYRLHMAVADKWIELLKGNDEAWEMGNIVHTLTNRRWLEKCVTYAESHDQALVGDKTLAFWLMDKDMYDFMALNGPSTPNIDRGIALHKMIRLITMGLGGEGYLNFMGNEFGHPEWIDFPRGPQVLPSGKFIPGNNNSYDKCRRRFDLGDAEFLRYHGMQQFDQAMQHLEEKYGFMTSDHQYVSRKHEEDKVIVFEKGDLVFVFNFHWSNSYFDYRVGCLKPGKYKVVLDSDAGLFGGFGRIHHTAEHFTSDCQHDNRPHSFSVYTPSRTCVVYAPMN
73
A0A2K1KPB8
1.1.1.37
ACT_SITE 208; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
MAARFAAAGLLKRALSSAPQQQVRCMSSQTPKRKVAVLGAAGGIGQPLGLLMKLNPLVTDLSLYDIAGTPGVASDLSHINTGANVEGFAGEQELAKALKGCDLVIIPAGVPRKPGMTRDDLFNINAGIVKSLASAIAEHCPGALVNMISNPVNSTVPIAAEIFKQKGTYDPKRLFGVTTLDVVRARTFLAHKKGLNVKDVDVPVVGGHAGITILPLFSQATPKVDLSDEELEALTKRTQDGGTEVVQAKAGKGSATLSMAYAGALFAESCLKGLNGAPDIVECSYVASTVVPGLPYFSSKVRLGPNGIEEILGLGSLSDYEQKGLEGLKSELMSSIEKGVNFVNVKA
5
A0A0A0KPG9
3.1.1.11
ACT_SITE 358; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MAQKLHFSIILFSMFILSSSSLPFSTKTNNKAIELWCSRTPYPDVCKHFFNNGEFDPRNLLDIKKAALKIAMERAMKTETLTKALGQKCRNKKERAAWADCLELYQTTILHLNKTFSDKNCSNFDIQTWLSSALTNLHTCRAGFVDLGIKDYGVVFPFLENNNITKLISNSLAMNNCSESDEGNTSDEGFPKWLHGGDRRLLQAAEPKADLVVAQDGSGNYKTVQAAVDAAGKRKGSGRFVIRVKKGVYKENVVIKVKNLMLVGDGLKYTIITGSRSVGGGSTTFNSATVAVTGERFIARGITFRNTAGPQNHQAVALRSGADLSVFFRCGFEGYQDTLYVHSQRQFYRECYIYGTVDFIFGNSAVVLQNCMIYARKPMQGQQCVVTAQGRTDPNQNTGISIHNSRVMATDDLKPVIKSVRTYLGRPWKEYSRTVYLQSFMDSLVNPAGWLEWSGNFALNTLYYGEFKNSGPGSSTANRVKWKGYRVITSASEAAKFTVGSFIAGNSWLPGTGVPFTAGL
125
Q83CW4
3.2.2.27
ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00148"
MTTMAETQTWQTVLGEEKQEPYFQEILDFVKKERKAGKIIYPPQKDIFNALKLTPYEAIKVVILGQDPYHGPNQAHGLAFSVRPGVPAPPSLQNIFKELHADLGVSIPSHGFLEKWAKQGVLLLNAALTVEAGKPQSHANIGWHRFTDKVIESLNDHPEGIVFLLWGSYAQKKSQLITNLRHRILKAPHPSPLSAARGFLGCRHFSKANQLLHEMGRGEIDWALDEKVS
173
H2LW37
2.7.11.1
ACT_SITE 312; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 329; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"
MEEVTCVPGQFDDAEVDRDQSEPSLLPSLINDVAAQRVDSDEEEDEVDDDYDDEDDEEDWAYHSAANLTSRLNRSGLNCQANRQNPSNKMISSSTPSDKALRKYEHKINLDKLNYADSVINKVTAMQRQKEADTYRVKDKSDRATVEQVLDPRTRMILFKMLSRGIISEINGCISTGKEANVYHAITASGESRAIKIYKTSILLFKDRDKYVSGEFRFRHGYCKGNPRKMVRTWAEKEMRNLIRLQMAGIPSPEPLLLRSHVLLMGFIGKDNMPAPLLKNAALSESKARELYLQVVQNVRKMFQDARLVHADLSEFNMLYHDGDAYIIDVSQSVEHDHPHALEFLRKDCSNVNEFFVKHGVAAMTVRELFDFITDPSITPQNMDRYLEKAMEMATERTSEQRSDQNHVDEEVFKRAYIPRTLTEVSHYERDVEMMKAALDEPSTCPQNDQVLYQTLTGLKKDLSGVQTVPALLEDEHPSSEEEEEEEEEEENAEEKAEKTPVDKKERKKMVKEAQREKRKNKVPKHVKKRKDKVAKIKKGK
99
Q8P8U8
1.1.1.49
ACT_SITE 229; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00966"
MHNTLILFGATGDLAQRYLFPSLLRLFVDGLLPEDFRIRALALSQHDTDAFREVLRPRLAQALPIATAAQIDALLQRIDYRSADLRNAESVAEAVRELASRQCVSYLAIPPGLYISTCQGLALGGALAAPHRLMLEKPIGHDSDSAREILQSIGALIDEDRVFRLDHYLGKAAVQNLVALRFGNTLLEAVWNRTYIESVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAMEPPASLEADRIRDEKVKVLRALRPMTAEHAAQDSVRGRYTAGSINGEPAQAYHPPEGSDVETFVAVTAHIDNWRWAGVPFHLCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLTFQLQPLENIELGLMSSLAGPEWGAIELQPLELELSVPTGLHRRIAYERLFVDAFNGNPALFVRDDEVKAAWAWIDSVSDAWSDAQLPLQPYPAGSWGPETAAPFLPPATDAQGNNA
6
P38991
2.7.11.1
ACT_SITE 227; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MQRNSLVNIKLNANSPSKKTTTRPNTSRINKPWRISHSPQQRNPNSKIPSPVREKLNRLPVNNKKFLDMESSKIPSPIRKATSSKMIHENKKLPKFKSLSLDDFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDFGWSIINPPENRRKTVCGTIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPPFEEEMKDTTYKRIAALDIKMPSNISQDAQDLILKLLKYDPKDRMRLGDVKMHPWILRNKPFWENKRL
99
A0A3Q7F950
5.3.1.8
ACT_SITE 311; /evidence="ECO:0000256|PIRSR:PIRSR001480-1"
MEMEEGFKGLLRLIGSVKNYDWGRTAKESCVGRLYRLNSRTKIDEKQPYAEFWMGTHDSGPSYIVVERGGRIQNGHANGGGIRDKCSLKDWIQKNPSVLGETVLAKWGTQLPFLFKVLSIEKALSIQAHPDKDLAILLHKEQPLVYKDDNHKPEMALALTKFEALCGFISLEELKVIVQTVPEIVEVVGNALAELVLDLSEDDEEEKGKLVLRKLFTEIMSASKDVITEVLAKLISRLNIKNKVRVLTDKEQLVLGLEKQYPSDVGVLAAFLFNYVKLNPGEALYLGANEPHAYVYGECVECMATSDNVVRAGLTPKHRDVRTLCSMLTYRQVLLELVLKAFFCSPCLSTVVGNPEILHGTAINPYTVRYLPPFDEFEVDHCILPPYSTVTFPSAPGPSMFLVMGGEGTMTTSAEVIVVEGDVLFAPANTNITIATSSGLHLYRAGVNSRFFEE
214
D8RPM5
1.1.1.100
ACT_SITE 220; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1"
MASASLISGFATTTPAAAPALQSRQHLRFGRNLQLCSSLSVRSSCSSSAIRAQVATATEPSHEPTKLVEAPVSVVTGASRGIGKAIALALGAAGGKVLVNYARSSKEAEDVASQIEELGGSALVYGGDVSKEEDVEALFKAVIDKWGTIDILVNNAGITRDTLLMRMKKSQWDEVINLNLSGVFLCTQAATKVMMKKKKGRIINISSVVGVTGNAGQANYSAAKAGVIGFTKTVAREYAGRSITANAIAPGFIASDMTAKLGDEIEKKILQTIPLGRYGQPEEVAGLVKFLALDPAAAYITGQVFNIDGGMVM
2
A0A8V0XQG0
2.7.10.1
ACT_SITE 1067; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
MLMPRRYLRRRGRSPAPSRARRSSVGAFASLPSPRKEPPAASGRTMPRQLLSGTVLLGAAFLLAGSTSGSKLKVPVLSVNGRQHVVQAGQTLNLTCRGEMLHSWSLPEALSKDSKRLNVTKYACGRNGTQFCSTLTLSRTQANDTGRYSCRYPTSPVKKKRESIVYVFINDTSNPFVEMHSDIPKIIHMTVGKEMIIPCRVTAPNIAVTLKKIPRETLIPDGKTIIWDNMRGFRIPEATYRFIGLLSCETTIGGHKYSTKYLTHRETNTIFDIKLSTPRLVKLLKGDSLAINCTVKAAWNTRVQMTWTYPGEAMKRGSVTQRIDQKNREANVFYSILVIDKVRDIDKGQYACHVKSGPSNKLVNTTVIVYDKRFINLKRRRKTMLEAVAGRKSYRLPMKVKAFPSPEVTWLKDGLPAAEKCARYMVKNYSLIIKDVAEEDAGNYTIILSLRQWNLSKNLTVTLKVNVKPQIYENAVSSFPDPNLYLLSSKQVLTCTVYGIPPPKITWMWYPCRQNHSKTRRGFCSRTDGSFNLKTGSNIGNRIQSIIERTAIIEGKNKTASTLVVAEAKSSGIYSCVASNKVGKAERNVSFLVTDVPSGFHISLEKVPIEGENLVLSCSANKFMYKDISWILPRTVTNQTKARKALNKEYSITLTLTIRNVSLAHSGTYTCRARNIFTGKEVLQKKDVSIRAQEAPALLRQLMDQTVNTSNSAMLECQVHGIPEPQITWFKNHEEIQQESGIILGPGSRMLFIERVKEEDEGLYQCIATNLKGSVESTAYVTVQGTVERSNLELITLTCTCVAATLFWLLLTLFIRKLKRPYFSETKTNHYLSIIMDPDEVPLDEQCECLPYDASKWEIARERLKLGKSLGHGAFGKVVQASAFGIKKSPTCRIVAVKMLKEGATASEYKALMTELKILIHIGHHLNIVNLLGACTKNGGPLMVIVEYCKYGNLSNYLKSKRNFFSPTKVRRQMPQDPSLQGELMKDKKGIEPVEGKKQRLASVTSSESFASSGFQEDKSLSDAEEDEEDAAELYKLPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDARLPLKWMAPESIFDKIYNTKSDVWSYGVLLWEIFSLGASPYPGVQIDEDFCSKLKEGTRMRAPEQATEEIYQIMLDCWRSNPNERPWFSELVKRLGDLLQASVQQEGKDYIPLDTIFTTESGFPPASDPLCNEKFPVPSPNCRSTERARYINTFKIKPPQRIKTFEELPIKEKLVFNDYQADSGMVLASEELKRFTWTGSKQKWTLFGMKGVSRSKESGLSGITKPRSFCSFSCDQLSESKRRYTYGNTVLEKMKACHSPPPDYSSVVHYSQPSI
97
Q54GY6
2.7.11.1
ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MVGGLPNSSLWNIEYDDLVFKDIIGKGNFGCVYRGNYLGVEVAIKQIPSFDDPDYCKYTEREVKALRYIRHPFVVHFFGACKHESGFYLITEFIEGLDLRRYLKSVPKPPKWLSRVNIALGVAKTFLFLHSKNLLHRDLKSKNILLDISRNQIKLCDFGFARVGSQYSNGSDSSSSEDESDSECVNGAAGGGGDDVYKNNGNGKPANYRLRRMSICGTPSFMPPEILLQQKYDWSVDVFSFGILCTELITLKRPGKDYWVRSQNNGFDINIEELNVNIPSPNDCPIQFYDLALKCCSYKHTNRPMFSTIVTILESIKLQLELFENQQQQQQLQQQQQLQQQQQQQQQQQQQQQQQLQLQQQQSSESSSSSSSQPLVNNNNNNSNCNNNNFNNSSNNNNSIANNDSISNVSTTTTSIPTTTTTTTTTTTTTNNITAINGTSNKYLQPLSKHQQQQQRNQNSSIIDNNSLIGSSNTESMITSFSISTFKERKKQSLNKLIRANTINILIGQQQQQQQQQQQQQQQQQDNQSSSQNQLIEREGVIKLDTTKYPNGWKEFGIDNSTNKIWIIYQSNIIKIGSNNNNNLIEMTCGTIIKLKKHSITLSIVDSNLISGANIINVKSYLKDYPYVNKPIKVNQQQQQQQQIITNNYELNLIIKLQSRIRGWLVRRRYKIFLSNWKLNNSNTSQSNKNQWIRLFNQLISSELEYKKQLDQVIKSYLLPIQSKFRINKPLLNYKEIGSIFSNIESLSEIHNELLKIVNQISKSPFFIMNFENEKDDRSNQNNTSATTDIFGDSSIQFTNISINTKDSSNQINSITQFIVKNISQIKNQYGIYAFNFKYSTNIYNWCRLNPDFSIFCDTIRSQLNQQFPDQENDLASLLSLPINKIQKYLLVFEKLAQITPITHSEYKDIKSAFTLIRETSNYIQSQLEMSFEHSHIMSIDIMLQKKDNQSLMQSGRWFIRQGQFTELSSNKQYYLFLLSDICLITKPIKSKSSKYNNNNNINTNNNNNNLTSSATQTNSNKDLSTSINQSTSNANSDNSGNNNNNLINSKYYYRLKTIINLKEEVSMRINPDISNGVLFIGPNKTYKWLLPNDEEAKDWVNDFERTTILIYRNNPNGGGSNNNSIGGGGGGRGGSGNNSNNGSIDLTEINQIHHINNQAIPLSSSNNNITNNNSINNNIIMNNNNNNNKDTEGKGFIKRFRLSFSAGTSTPERKTSLVNMSPSTTSSLNNIDSNYNNNNNNVTNTPIKSVTSSPSIHYTPVNDNNQQPQLPSQPNEEFQFTVPTTPSDKKKKRGSFSSKLKRLSITFSKD
99
H9G7D1
3.1.1.4
ACT_SITE 71; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 116; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"
KGEATLRCDTFCLVALPGPVLVTGVASQLNEMIQLSTVTFSLANFTNYGCHCGPGTQGFPVDDIDRCCHGHDCCYNKAEMFGCTPHLHTYRFYAQRDKIKCVKSRDRCEKLICECDRKAAKCFGKHIFTYNPQLKNHPMANCQAQRPFC
130
Q6DFJ1
2.4.1.18
ACT_SITE 344; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 399; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"
MATEGKEVQVEVPELDVLLEQDPYLKLYEKDFRRRYGLYTQLLKSIEGNEGGLEKFSRSYQSFGIHVLANGGICCKEWAPGAEAVFLTGDFNGWNPFSHPYKKMDYGKWELHIPPREDNSVIIPHGSKLKVVITSKSGETLYRISPWAKYVVREDKKAVYDWVHWEPLQPYKRKYATPKKLKSVRIYESHVGIASPEGRIASYKNFTYNVLPKIKDLGYNCIQMMAVMEHAYYASFGYQVTSFFAASSRYGTPDELKELIDVAHSMGIQVLLDVVHSHASKNSEDGLNKFDGTESCFFHDGARGNHDLWDSRLFDYSNWEVLRFLLSNLRWWMEEYGFDGFRFDGVTSMLYHHHGIGCGFTGDYNEYFGLQVDEESLVYLMLANHMLHTLYPDCITVAEDVSGMPALCCPISQGGAGFDYRLAMAVPDKWIQILKELKDEDWNMGNIVHTLINRRYNEKCIAYAESHDQALVGDKTLAFWLMDAEMYTNMSVLSPLTPVIDRGIQLHKMLRLITHGLGGEGYLNFIGNEFGHPEWLDFPRKGNGESYHYARRQFHLIDDQLLRYRFLYAFDRDMNNLEEKFGWLAAPQAYISAKHEGDKIIVFERANLLFIFNFHPYKSFTGYRVAVNTPGKYMIALDTDASEYGGHQRINHSTEFFTEDAPYNNRSHSLLVYIPCRVALVLRNVNYS
73
Q817M1
1.3.5.1
ACT_SITE 284; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1"
MKGKLIVVGGGLAGLMATIKAAEAGVNVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTIYGGDFLANQPPVKAMCEAAPGIIHLMDRMGVMFNRTEEGLLDFRRFGGTQHHRTAFAGATTGQQLLYALDEQVRRHEVAGLVTKYEGWDFLRAVVDDEGVCRGIVAQDLQTMEIRSFGADAVIMATGGPGIIFGKSTNSIINTGTAASAVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVEQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEKFTGDDPRKLPMKIFPAVHYSMGGLWVDYKQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGMVAGPNATEYMKGLSKSSDAVSSTVYEQNELIETEKFNNILTMDGNENAYVLHKELGEWMTDNVTVVRENKKLLETDAKIEELMARYKRININDTARWSNQGASFTRQLANMFELARVITIGAYNRNESRGAHYKPEFPNRDDANFLKTTMAKFEGEGNAPAFHYEDVDISLIKPRKRDYSSKHDVAAKGEEKGDKQHV
28
Q6ED60
3.1.3.48
ACT_SITE 837; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR002004-1"; ACT_SITE 1153; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR002004-1"
MTMYLWLKLLAFGFAFLDTEVFVAGENPTSPTTGPTATKKSSVPLSGDPLPTHTTAFSPASISERENGFLETTPSLSPASTSTQVSLDSLDNASAFKTTGVPSEQPPHLPTQADSQTPSAGTDTQALSGLAAHATLSPAPGSNDASDVPGERSTASPFPTDPVFPLGTTPIPARNSSAALPARTANTTITASSPDSHALETITLSPSGSTAHSTKIVATTPAKPSCDEKYANITKLFTAKLNVNEVVKCAEFDCTNNMLHNLKECEIRTVTISDNSCTAPNKTLILDVPPEVDKFHLKDHTSPEKANTTINLKWENTENFTKITYRFQCGKITSDKEYIVLEDRKPNHNYTCYSEILYNHRKYININETIQTDFGIPEEPQNVTCRSEDAHEGVITWNHPHSLFHSFTLCFPDKPDNCFQVDKNLTKYDLQNLKPYTKYVLSLHAYIIAEVQRNGGAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSVEEGTRAFGDVVVKINQHKRCPDYIIQKLNIINKKEKTAGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVDKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDFNRVPLKHELEMSKESEHDSDESSDDDSDSEEASKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVLKQKLPQKNSSEGNKYHKSAPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDVFQVVKALRKARPGMISTFEQYQFLYDTIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEANEQAAGSEPTSGTEGPEHCVNGPASQALNQGS
149
Q05609
2.7.11.1
ACT_SITE 676; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MEMPGRRSNYTLLSQFSDDQVSVSVTGAPPPHYDSLSSENRSNHNSGNTGKAKAERGGFDWDPSGGGGGDHRLNNQPNRVGNNMYASSLGLQRQSSGSSFGESSLSGDYYMPTLSAAANEIESVGFPQDDGFRLGFGGGGGDLRIQMAADSAGGSSSGKSWAQQTEESYQLQLALALRLSSEATCADDPNFLDPVPDESALRTSPSSAETVSHRFWVNGCLSYYDKVPDGFYMMNGLDPYIWTLCIDLHESGRIPSIESLRAVDSGVDSSLEAIIVDRRSDPAFKELHNRVHDISCSCITTKEVVDQLAKLICNRMGGPVIMGEDELVPMWKECIDGLKEIFKVVVPIGSLSVGLCRHRALLFKVLADIIDLPCRIAKGCKYCNRDDAASCLVRFGLDREYLVDLVGKPGHLWEPDSLLNGPSSISISSPLRFPRPKPVEPAVDFRLLAKQYFSDSQSLNLVFDPASDDMGFSMFHRQYDNPGGENDALAENGGGSLPPSANMPPQNMMRASNQIEAAPMNAPPISQPVPNRANRELGLDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAVPPPNRSDL
99
Q869T7
2.7.11.1
ACT_SITE 514; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSNLKLSNNNNGNQKESSSFFQKVMKSPSTQNLLNSFSSNNSNNNLSNSGSNEVKDTTTNSPSQLPPNYTPPPPPHQIRNSSSIEGGEFSLLNNENSDNNNNNNNNNNNNNNNNNNNNNNNNNNNEQLARTESSVSIISSSSSGSNSGQPNLQRHSSNISTDDSNTTTETYSMSPNQTLNSNIDSSEQQHQDLSSSVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTHESRKLTRKIAQFISSPKLLQSSISQLPSTPTQQNVEIQTTNGGSSETSPNGLISPRPSNDQPLKEKKKKKFLKTPEIFKHHHHHKESSLSSSTTTPSTTSSLTSSPSSSSLAISSPNTTAATTTNKKSHKKTKSTFDINTEISVPYNVIHKMHVDFDLKWTGHNDFILDEKLGDGAYGSVYKGTHKDLGFTLAIKVIEMKESESVSLQNEINILKNCKSPNIVSYFGSLQTESHIWILLDFCALGSIRDIIESTEKTLNEAQISFVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGVSEKLNGALDQSKEMIGTPLWMAPEVILKKNYDYKADIWSLGITIIEMADGLPPHIDLPPMRAMKMVPNWPPPTFAEPKKWSPLLNDFLARCLVKDPEKRASPIDLLCHPFLKKDRGPDVLSDLVNQLFKIKKKKIDDLKKQQKHQTSQSSSSSSPQSPNATVNGGDIGSDGLSTSIISPIPSSPSDELDNCNNSLKLATSSKGMLSFKGNYTTCRDFQEEEEDSKHLNNNQDEQDDEQDDEDDDDENEDDEDVDPFSTTIFHGKKKGSGNGNGGVTSDQDDEEEDEEEDDEEEEEEEEDDDEINEDEEISATGTMVVRKKKNKSTKKSNKKKNKKNNLSTIGKSGSGNNLLHVAPNKPLPITPPFSISMTNEFKQLETKLFTYIDSSNQKIVNDIKNEIKQLESSIINKININLQQQLSPILLALEEIKQNQHTTSQPKQMQSKLSATNLNEKKLSSSPPSSNSPLTNSVNSSLTTTTTTTTSPVLSRQSSFRSSGSISSSNSSFRPNSAIMSAVNNSSTTTTTNSNSSSSNGGGSGVDISPTMTGRASPSIMKRFTTSSSSSPLSSSSDGFAFNSNSNSSSSDLKRHVITPEELNNSNLVKNKVKMFEDDNSSGSGSNSPSLSTNSSSTNSNNSVTNIKK
99
D8S2R2
1.11.1.24
ACT_SITE 69; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
MVELFLFFQTIDFNLHKYQIDRPLVGSMAPNFEAEAVHHQEFIKVKLSNYIGKKFVVLFFYPLNFTFVCPTELTAFSDRYGEFQKLDTEVLAVSSDSVFSHLAWIQTDRKSGGLGELNYPVVSDLTKAITKAYRVLLPDQGISLRGLFIIDKEGIVQHATINNLAVGRNVDEALRLVQAVQYVKVHPDELCPAGWQPGEHGIKPDPKHFAAV
12
O14299
2.7.11.25
ACT_SITE 1161; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MGLEHTFYPAEDRFEPLLEHSEPVNFVPKENAKSYVRQGFASPHQSLMDNLVDSTESTKRSENFVSHIPLTPSHSGQSEKLMSTRTSHSPYISPTMSYTNHSPANLTRNSSFNHQHYSTTLRSPPSMRGRGIDVNSSHYPHISRPRTSSDSQKMYTRAPVDYYYIQENPYFNNIDQDSISDKSLPSTNQSLHHSEEDTESDNDFSESIHPEFDIDVFYKVSNILYDESDLQDPEKRERLEWHSMLSSVLKGDVMQTEKRRLRLTEPDGHSGTYISEVWLGLQAWLHGRLNADQAEVIRKSREGVEPVLREVIDFQIQDEETTKPPLEQVTEILEKVEQCKQFYISSREMEENVPLSASKEFNYKLNALISWSNVMESIQVETLVLQKWVGNDEFDLTMRTPQFNYDGVENTSSFVERIFRQSGLQRTFEQRTLTTLNRIIHQAKQTISENAQAFEEMKLPTYEDKLLPLVRFPIKLLEEALRLRLAYAKKIKGPNFLIVDSMLDDFKIALSVAVRIKREYIKIASPSPGWSLPTNVDEDYDNVLLDSLKFYFKLLTLKLSSGNKNLYFKEIDFLENEWAFLNEHIYWINGGDIHMAGQFSYLSNSLLLNVHRYVESHLNGPTERTAASLTNWYSTLLKNTQIRFRKILRFSETLNSRFENASDFVISEGHLPDLVNRLSTTGHFLAYTANLERDGVFVIADHTLSENPEALKALLFSKDISNLETIQQNCSYVLILCPVHPIVWKGRIEKVDVPDFSVDLKTNRVRIIASNKREHLQAAKSVFQSISGDLVTLAVECRSSITRVYKEFIRLSKLCMRISSTVVDCVSAVREACSGVNCHDLIYHVFSFAAEFGQRILRFLSFDSYWQTKLKRKITSLAVEWISFICDECDLMDRKTFRWGVGALEFLMLMIRGNNILLIDDAMFLKIREKVGKSMAFLLTHFDVLGAKSKVAAKLQRESTEVSSSPRLTSFGDVEEEALSIQLLQKETMLRIDELEIERNNTLLERLAIGHVLDDSVFRNRDFIKLASSFSNITIRWQQGHFVRSGMFGDVYTGVNMETGDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERLNHPNVVTYYGVEVHREKVYIFMEFCQGGSLADLLAHGRIEDENVLKVYVVQLLEGLAYIHSQHILHRDIKPANILLDHRGMIKYSDFGSALYVSPPTDPEVRYEDIQPELQHLAGTPMYMAPEIILGTKKGDFGAMDIWSLGCVILEMMTGSTPWSEMDNEWAIMYHVAAMHTPSIPQNEKISSLARDFIEQCFERDPEQRPRAVDLLTHPWITDFRKKTIITMPPATITKKTSLSHTITEEKTAQLLAGRHDDSKAETDSLAASYKEESALPVASNVGLRQPNELRIDSINLPPAIVTPDTINYSVD
105
F6PPJ1
2.7.11.13
ACT_SITE 364; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000554-1"
RDIVKMSIDAGSHQILAKVYYSGHAFSLHLEHTIQMEELFTMVRLNCNFPDAQVFTLKWMDDEGDPCTISSQLELSEALRLYRHNNETVLLFHIFLGIPVEPGLLCPGEHKLYRHGARRWYKLKRILRQIKKPKHPRIPIESGPILDSGDSQDSKQFHPRFCYNECNCILTMSPQIFKQNLKQLLLHIPPSFCLSNYRSYLVVTPYVLCKQTPIYTKYKQTSASSDQASPNAPGFGLKDFEMLKVIGRGSYAKVLLVKLKSTDKMYAMKVIKKELVTDEEDIDWVQTEKHVFETASNYPFLVGLHSCFQTPERLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEIVLALHFLHEKGIIYRDLKLDNVLLDSDGHIKLTDYGMCKEGIRKGVNTSTFCGTPNYIAPEILRGEDYDFSVDWWALGVLMFEMMAGRSPFDIVGMTDNPEQNTEDYLFQVILEKVIRIPRSLSVKASSVLKGFLNKIPVDRLGCNHESGFQDILDHQFFRTIDWDLLQSRQVVPPYKPNIEDDLGLDNFDKQFTQEPVQLTPTEATVIGKIDQADFEGFEYINPLLMTSDVAV
100
A7REY1
1.1.1.205
ACT_SITE 341; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 439; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"
MASSPSKSAPKADYLISGPTSYVPEDGLTANALFGGGQGLTYDDFLILPGFIDFSADVVELNSALTREITLKTPFVSSPMDTVTESAMAVAMALHGGIGIIHHNCSIEFQADEVKKVKKYKQGFINDPLVLSPRHTVKDVIEIKKKNGFSGIPLTENGCMGGVLAGIITSRDIDFLGPEQIDEPLSEFMTPLNDLVVAKDDCTLQEANRILQQSKKGKLPIVNENGELVSLIAYSDLRKNREFPLASKDSKKQLLVGAAIGTRAEDKLRVEALIHAGVDVIILDSSQGNSAYQIDMIKNIKELCPRLQVVAGNVVTACQAKNLIDAGADALRVGMGSGSICITQEVMAVGRPQATAVFKVAEYARRFGIPVIADGGIRTVGHITKALSVGASTVMMGSLLAGTSEAPGEYYFSNDGVRLKKYRGMGSLDALENKSSQSRYFIESERIKVAQGVSGAVVDKGSIHRFVPYLLSGLQHGCQDMGCQSLSVLRSMMYSGQLKFEKRSSAARIEGGIHSLHSYEKRLY
3
A0A1B6Q5Z8
3.1.1.11
ACT_SITE 256; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MGMRRARFLACIAMAAIVLLAPPSTCGVAGHSRGLRPGRSAGAGGAGDPPPLFPVNATRAEMIERQFMEWVRYMGGLRHSTFQHALARAFPSYSLVVDKNPAFGDFTTIQAAIDSLPVINLVRVVIRVNAGTYTEKVSISAMRAFITLEGAGADSTIVQWGDTADSPTGPKGRPLGTFNSATFAVNAQYFLARNITFKNTSPVPKPGATGKQAVALRVSADNAAFVGCKFLGAQDTLYDHSGRHYYKECYIEGSVDFIFGNALSLYEDCHVHAIARDYGALTAQNRQSMLEDTGFSFVNCRVTGSGALYLGRAWGTFSRVVFAYTYMDNIIIPNGWYNWGDPNRELTVFYGQYKCTGPGASYAGRVAWSHELTDDEAKPFISLSFIDGTEWIRL
125
B8BUV0
3.5.1.2
ACT_SITE 87; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 214; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 216; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"
MTTPSITIGVLALQGAFEEHQRCIESISPSITTLQIRTPSQLSQIDGIIFPGGESTAMGLIGDATTGLWGALRTFVRESGKPTWGTCAGMILLAERCVGTSAVITKGQSLIGGVDILVCRNYFGSQISSFEMDTPAPPRPEVCVDGMTSCSSAEEGENASFPGVFIRAPAILTAGAGVEVLGKVVAAPWASDETNAREVICAVKKGNILCTAFHPEIADDLRWHEYFVGMVLASKQSA
181
F6WYP6
2.7.10.1
ACT_SITE 749; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
MERRWPLGLGLLLLLCATLTPGARAKEVTLMDTSTAQGELGWLLDPPEDGWSEVQQMLNGTPLYMYQDCPVQEGGDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGARPLGCKETFNLLYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLASGSVKLNVEHCSLGLLTRRGLYLAFHNPGACVALVSVRVFYQRCPEAVHGLAQFPDTLPRLGGLVEVAGTCLPHAQASPGPSGAARMHCSPDGEWLVPVGRCHCEPGYEEGGDGEGCLACPGGSYRADMGAPHCLQCPQHSTAETEGATICTCEDGHYRAPGEGPQAACTRPPSAPQNLSFSVLGTKLSLSWQPPADTGGRQDVRYSVGCSQCRGAALDGGPCQPCGGSVRFSPSADGLAAPAVRVDGLEPYANYTFNIAAQNGVSGLDTSKPASALLSISMGHAESLSGLSLRLVKKEPRQLELTWAGSWPRSPGGNLSYELHVLNQDEERHQMVLEPRVLLTELQPDTTYIVRVRMLTPLGPGPFSPDQEFRTSPPVSRSLTGGEIVAVIFGLLLGVGLLLGILVFRSRKSKRRRQQRPRDHVTSVNREDKLWLKPYVDLQAYEDPAQGALDFTQELDPTWLIVDTVIGEGEFGEVYRGTLRIPSQDCKTVAIKTLKDTSPDGQWWNFLREATIMGQFNHPHILHLEGVITKRKPIMIITEFMENGALDAFLREREDQLIPGQLVAMLQGIASGMNYLSDHNYVHRDLAARNILVSQNLCCKVSDFGLTRFLDNSDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVSPGQSSPHHPSVASHPFPKSSCKYLYFFFLIHSFSVLLSVLVTLAHTLCTTPTLVRGLRGSIAMLLGEQRFLTGRQVSFLPQASFPSLLLQVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFHQLKAHLDHLLANPHSLRTIANFDPRSHWGGQIWENGNGPHSQFSHIHQVLGLGASI
97
G1KJ54
2.7.10.1
ACT_SITE 1020; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
MYTNGYEHLVYLHTVLIRLFFKFCFLGSSLGSRWKGPKLNITGTQHVIQEGDSLNIMCSGEVVHSWSLPESLTKDSKRVDIITSTCGRNGKQFCSSLTLNRAQPGDTGYYRCKYPSSSALRKKTVSKIYVFINGTHNPFVKMHKDVPETILMMDGQELIIPCRVTAPDIRVKLKMNQGESIMPDGKTIIWDSTKGFVIPNATYKFIGLLACETNVDGHDYSTNYLTFRQANEILSVQLNASRPVKLLKGHNLVLNCTITAAWNTRVQITWKYPGEASKRGTIARSIVQRSDEPNLFYSILVIDKVRDIDKGQYTCNVKSGPSLKSVNTTVHIYDKAFITLKPRRKNVLEVLSGKKSYRLSIKVKAFPTPEVIWLKDGLPAAEMCARYKIKGYSLIIKHVSEEDAGNYTILLNTSPWNLHKNLTVSLRINVKPHIYEKVSSISGPNLYKVGTEQILTCIVYGIPQPTFQWIWHPCQQNHSLARHDFCSNPERSFILKSGSSTGNKIKSITQRTAIIEGKNKTASILTVAESRSSGSYSCIASNKVGSDERSISYFVTDVPNGFHINLKKTPVEGETLALSCLANKLLYKDIAWILPRTVNQTRIKKPAVKDYSIDLTLIIKNVTLEHSGTYACRARNIFTGEDVVQEKDVTVRAQEAPYLLRNLTDQVINTSHSVSLECHVYGVPEPQISWYKNNKQILQEPGIILGPGSQSLLIERVQEDDAGQYQCVASNLKGTVESSAYVTIQGISESSNLELITLTCTCVAATLFWLLLTLFIRKLKRPSPAEIKTDYLSIIMDPEEVPLDEQCERLPYEASKWEFARERLKLGKTLGRGAFGKVVQAAAFGIKKSPTYKVVAVKMLKEGATANEYKALMTELKILIHIGHHLNVVNLLGACTKSGGPLMVIVEYCKYGNLSSYLKSKRDFFVTNKDTSIQEELIAEEKEAEPTGSRKKRLESIPSHESLASSGFQEDKSLSDVEEEEEDSGDFYKRPLTMEDLMSYSFQVARGMEFLSSQKCIHRDLAARNVLLSENNVVKICDFGLARDIYKNPDYVRKGDARLPLKWMAPESIFDKIYSTRSDVWSYGVLLWEIFSLGASPYPGVQIDEDFFNKLKEGIRMKAPDFATSEIYQIMLDCWQGDPNERPRFSELVERLGNLLQANVQQDGKDYIPLNNILSVDSGFDCSPLISPNPHGMESDSVTVLNYTVSENNGRHINAFRMKPPQRVKTFEELSPKDKFEHEDCQVDSGIALPSEEPKRFTWTGSKQKHLFFGLHSAKRSKESLLSNITKRDFYSFSCGHISDVTQPFTRDSITLGEKHGFPPPNYNSVVRYSTPPV
97
A0A9R0I6T9
5.1.3.3
ACT_SITE 173; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 306; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MADQPKKAEIFDLDNGSMHVKISNYGCTITSLSVPDKDGKFADVVLGFDSVDPYLQGAGSYYGCIVGRVANRIKEGKFTLNGVEYSLPVNNPPNSLHGGKNGFDKKIWDVVEYKKNDTSPSITFKYHSRDGEEGYPGDLSVTATYTLTSKTTMKLDMEAIALNKATPVNLAQHTYWNLSGHNSGSVLNHHIQIWANHYTPVDKNTIPTGEITTVKNTPFDFTSEKRIGQDIDKVIGLGYDHNYVLDSGDEKMGLKHAAKVREPKSKRVLDVWTNAPGVQFYTGNYVNGVTGKGGAVYDKHGGLCLETQGFPNAINQPNFPSVVVEPGKKYQHSMLFEFSTV
211
Q9X2I6
4.1.1.17
ACT_SITE 321; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MMEYWIRRALEVVKTPFLLFDLSVVEKKYLEMKAALKKADIYYAVKANSHPRIISLLARLGSNFDVASKGEIEKLLALGVDGKRMSFGNTIKREEDIAFAYKNGIRLFAVDSEMEVEKVAINAPGSFVFVRVETDGADADWPLSRKFGTNPEHALQLLSYASKMKLIPAGLSFHVGSQNLNPESWKKAIEIAGRVFKKAMRSGLNLFLLNVGGGFPVQHTKPIPSMEEIGKAIEEAIDENLWFVHNLKVIAEPGRYMVGEAGWLVTKVLLKSERSGEKWVYIDAGVFHGLAETIQNFEYEIRVLGKEREELEEYHLAGPTCDSVDVIYDRIFLPKSITLNDLVCFINAGAYTVEYNTRFNGIEPPKMVFIEELTEISIEEKIKTRVLD
195
A0A9J7LD89
3.1.3.1
ACT_SITE 134; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
MAGTTAVLVAYSLLAVLVTVKSGSVDEHAHRARSITRENGGAPEREKNPQFWNNMAKNSIQDALRIQRSHNMKIAKNVVMFLGDGMGVVTVTSARILKGQNAGNPGEETVLTMDTLPHVALSKTYNIDAQTPDSAATATAYLCGVKAAYATVGVDGRAWNKDCSSSKGAEVQSILALAESAGKSTGVVTTARMTHATPAATYAHSASREWEADRDLSPEAVQNDCKDIATQLVDDNPGIEVLLGGGRRNFHTGTDPEYPDDPGSNGVRSDGRNLVQDWLVGKTSARYVWNGTDFRTVNPQTTDYLLGLFEPSHMKYMTDRDDSPSEEPTLAEMTRTAIQILQKNRNGFFLLVEGGRIDHGHHDGKAVKALTEAVAFDDAIKVGKDMLNLEETLIIVTADHGHTVSFGGWDTARGSPVFGKLDPDYFVESEGVNLVPDGKPYTAIQYGTGPGYNISAPREDITNVDTAHPDYLQQSAVPTVVESHGAEDVAIFADGPMAHLFHGVHEQNYIAHVMKYAACLGEYAEDCDREERVASGTARGSFSTAAVLSSIFLQLVWWL
141
F4J270
3.2.1.39
ACT_SITE 127; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O22317"; ACT_SITE 264; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O22317"
MKMCNGSSFLASLPLLLLLLSFILASFFDTAVGQIGVCYGRNGNNLRPASEVVALYQQRNIRRMRLYDPNQETLNALRGSNIELVLDVPNPDLQRLASSQAEADTWVRNNVRNYANVTFRYISVGNEVQPSDQAASFVLPAMQNIERAVSSLGIKVSTAIDTRGISGFPPSSGTFTPEFRSFIAPVISFLSSKQSPLLVNNYPYFSYTGNMRDIRLDYTLFTAPSTVVNDGQNQYRNLFHAILDTVYASLEKAGGGSLEIVVSESGWPTAGGAATGVDNARTYVNNLIQTVKNGSPRRPGRATETYIFAMFDENSKQGPETEKFWGLFLPNLQPKYVVNFN
167
H2XKZ9
4.1.1.17
ACT_SITE 321; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
ESDSSFYLGDLGQIVRNLQMWRKHMPQIRPYYAMKCNPSQPVIQLLASLGVGFDCASGFEIESALKCGVQPDDILFAVPCKMSSHIKYACQTGVRTMTFDNADELHKIKRIHPTGKLLLRLRVEYCGIGIKMDDKFGASMSEAEKLILLCKELKLNLAGICFHPGSGSNSFDPIDRSLQQCRELYDFANLNGIDLKIIDIGGGLVCTESFIKVSFQITTAVNKLFPPETGVKVIAEPGTFLVENAFSFVTNVHGKALVGVYVGINISKSLSTDTAKYYIGAGVFTAFNLKFFEEFKRIPENLSREAEKGKYYRTSVYGPTCAGDDCVVDNIMLPEAQINDWWIFDNMGAYSSLVSLGFNGY
195
B9RA28
1.11.1.7
ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MIMIVKAALLILALGLFLGNLAGLCNGALQVGFYSGKCGFADVEAIVAGVVTPQFFKDPTIVAALLRLQFHDCFVNGCDASLLLDGRSSEKTAPPNLSVRGYDIIDQAKTAVERACPGVVSCADLIAIATRDVVFLSGGGRYNVQTGRRDGLISAGQNVSILGPKASVPEAVAAFAEIGLNTTDMVLLLGAHSVGVTHCSLIKDRLYDFEGSGNPDPLMDPFLVNLLRFRCPQFPAIDNTVNLDQNPFSPFFMDVSYYQNIMMHRGILQIDQELGMDPLTMPIVRNLAGEFDFPTRFGAAMVKLGTIGVLTDKQGEIRRSCRATNNET
14
M5WH45
2.3.1.286
ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
MSLGYAEKLSYIEDVGQVGMTEHFDPPPVLQEKIERLAMLVQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQREGKALPEASLPFHRAMPSMTHMALVELERAGILKFVISQNVDGLHLRSGIPREKLAELHGNSFLETCPSCGVEYLRDFEVETIGLKETSRRCSDKKCGARLKDTVLDWEDALPSKEMNLAEKHCRIADVVLCLGTSLQITPACNLPLKSLRGGGKIVIVNLQKTPKDKKANLLIHGLVDKVISGVMDFLNLQIPPFVRIDFFQIILTQALSSDKKNVNWNLRVASVHGQKAPLPFIKSIEISFLENQGYKSAILQKEPFQLKRRTLQAKSFEMVMKFNFIDSCGCPSTEIIVPLNFKVSRDCFELDKDAILQKLRHTAIQESCCGQNAVVERNAMLTPKTEVIVYAIVTNVIRYKKTTEALEADSLGNGVKRRRESANGTETSRKRSKVHRRKPRF
58
A0A2R6WR46
1.11.1.7
ACT_SITE 98; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MATMGRLVVVVVVVVVAALSLATSVAGARVELQQFAPSVNLGANLSSLEQQLPLEAGLVWGYYSKSCPRAESIVTQKVSEAIRNDPGIAPGLLRIFFHDCFVKGCDASILLRNSRGSELNDVPNRTIRQSALNLIDQIKAALEQACKGVVSCADIVVLAGRDSVKLAGGPSFNVPLGRLDSFTIFPTNALPTPFASFNDQLNGFKAVGLNTQDLVALASGGHTIGISQCASFQGRIFPNLDPKLNKDFGNALRQMCGNSGNTVGIDFFTPNKFDNQIYKNFLTGGALLLSDQNMDSDSTAWNLVKTWANNQGAFFNQFLSSYIKMSQINTLSGRAGEVRRVCAKPNNMADEFEPEIKLVTDN
14
P9WG33
2.2.1.2
ACT_SITE 143; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000250"
MTAQNPNLAALSAAGVSVWLDDLSRDRLRSGNLQELIDTKSVVGVTTNPSIFQKALSEGHTYDAQIAELAARGADVDATIRTVTTDDVRSACDVLVPQWEDSDGVDGRVSIEVDPRLAHETEKTIQQAIELWKIVDRPNLFIKIPATKAGLPAISAVLAEGISVNVTLIFSVQRYREVMDAYLTGMEKARQAGHSLSKIHSVASFFVSRVDTEIDKRLDRIGSRQALELRGQAGVANARLAYATYREVFEDSDRYRSLKVDGARVQRPLWASTGVKNPDYSDTLYVTELVAPHTVNTMPEKTIDAVADHGVIQGDTVTGTASDAQAVFDQLGAIGIDLTDVFAVLEEEGVRKFEASWNELLQETRAHLDTAAQ
52
A0A9R0IAD9
3.2.1.143
ACT_SITE 301; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 319; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 320; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"
MCTLIYVQPSTIRALKFLPQKSKPSAPIIIKMVNRADFKSVLPFLPPLKSLTSGSLAWPNPQVTAALELVSQGPSRSRVDSGERLYAAISRVRGSLPLSAKDRLAKSTDKGFAKLFDELLPKEESRRWLENVAPKMADLVLRLPALLESHYRDCDNVVPGVSTGLRLLEPQQSGIVFLSQELIAALLSCSFFCLFPTVNRKAKRMRAINMDQIFSSLHDSYHTKQENKMKCITHYFERICSSTPSNFVSFERKVLSLEQNPSVVPLPSPEFWANSVTPLCKFKVFPTGKIEHHPPGASEVDFADEFIGGLVLTKGCVQEEIRFMMNPELIASMLFMPSMSENEAIEMVGAERFSNYRGYNASFQYTGDYIDRRGVDALQRRMTRVVAIDALRKAGTKQYQSQFLLREVNKAFCGFLDHTEYLQQQVHESNVGVATGNWGCGIFGGDAQLKSMIQWVSASQASIPFVSYYTFGLDKVQNLDQVVEWIVSQKWTVGDLWKKLVDYGAQREGRSKIGFFSYLMPSLKQVSATSSKRSRSGSSAEENSRGRGRK
159
D8T5E8
2.1.1.37
ACT_SITE 562; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MAKVGTGSARSRKKSGPRRASATSSGTVKEEDVAAKEDPCPQRPSGDCIVVLDSSEEDQLSPSAVVREEDIGKKVDKKAGKSVQRKDPGPNPKPKPKPRKSFGPKKQPLPPPPSPDDDDFAQEPILVESDDDDEEDSPSAALVACPRKGHKLAVKAHFVGKPIPAARAKRQWPNRYDKSAGAGSQKCVEHYEEAVVDGKHYKVGDCVALELQGDDAEYLGKVLEFFKTANQENWFRVQWFFRFSDTVCLRLCGYPDCKCSLQAIGDLDDVHLDNKRVFLSDDEDDNMIECIIKKVKVSYAPVMDAFSKKKIKQSCDYYFDMGYTGDFSTFYKVPSGNVFVFSTDALEDASSSFQTAVTRCSDTIKPELILLDLYCGCGAMSTGLSMGAALGGVNLVTKWAVDYNEHACNSMKYNHPETEVRNEDAECFLLLLKEWQKLCTKYEGHVADDNSNASSPDSNTLGADEYAADEYEVQQVVDIRMAGIQKPKKPDTSSKMPEKPIKRRLEFKVRWKGYTSDHDTWEPVDHLDSCQERIRDFVLEGRRRRILPLPGDVDMVCGGPPCQGASGYNRFRNTEAPLTCPRNRQMVIFMDIVGFLRPKFVLMENVVDILKFQQGLLGRYAMFRLVDMRYQAKLGMMAAGSYGLPQFRMRVFLWGAAPSEMLPAFPLPSHDAIYKGNVPNQFSRNVVKHIGERQLEKALFLGDSISDLPPVKNCETRDEIPYRDGPKTEFQTRIRSARDDFTVFYGRGPRAMNSTVHDHRPLRLNDDDYQRACRIPKRKGANFRDLGGLKIKDDNSVTLDLTVEREYLPSGKPLIPDYAISFIKGRSLKPFARMWWDETVPTVITRAEPHNHRMLHPTQDRVLTVRENARLQGFPDWYKLTGSVKERYIQVGNAVAMPVARALGYSLALTTQRLCKEPRLELPAGFPCFESQE
47
Q8L6Y1
3.4.19.12
ACT_SITE 317; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 758; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"
MELLRSNLSRVQIPEPTHRIYKHECCISFDTPRSEGGLFVDMNSFLAFGKDYVSWNYEKTGNPVYLHIKQTRKSIPEDRPLKKPTLLAIGVDGGFDNNEPEYEESYSIVILPDFVSLPFPSVELPEKVRIAVDTVVNAVGAERKEQVAAWTAEKKLISEHALTLQQIKSGIVIPPSGWKCSKCDKTENLWLNLTDGMILCGRKNWDGTGGNNHAVEHYKETAYPLAVKLGTITADLEAADVYSYPEDDSVLDPLLAEHLAHFGIDFSSMQKTEMTTAERELDQNTNFDWNRIQESGKELVPVFGPGYTGLVNLGNSCYLAATMQIVFSTHSFISRYFSHQSLKMAFEMAPADPTLDLNMQLTKLGHGLLSGKYSMPATQKDATTGDPRQEGIPPRMFKNVIAASHAEFSSMRQQDALDFFLHLVGKVERASNTTPDLDPSRSFKFGIEEKILCPSGKVGYNKREDCILSLNIPLHEATNKDELEAFHKQKAGKGLEENDMRSSDEIVRPRVPLEACLANFASSEPIEDYYSSALKGMTTAIKTTGLTSFPDYLVLHMRKFVMEEGWVPKKLDVYIDVPDVIDISHMRSKGLQPGEELLPDGVPEEVMESAQPVANEEIVAQLVSMGFSQLHCQKAAINTSNAGVEEAMNWLLSHMDDPDIDAPISHQTSDIDQSSVDTLLSFGFAEDVARKALKASGGDIEKATDWVFNNPNASVSDMDVSSSNSAQTPAQSGLPDGGGKYKLFGIVSHMGTSVHCGHYVAHILKEGRWVIFNDDKVGISTDPPKDMGYVYFFQRLD
175
Q9KZL9
5.3.1.8
ACT_SITE 270; /evidence="ECO:0000256|PIRSR:PIRSR001480-1"
MDRLDNTVRPYAWGSTTAIPTLLGTEPTGEPQAEMWMGAHPGAPSRTGRGTLAEVVDADPEKELGAASVARFGPRLPFLLKLLAAGAPLSLQVHPDLAQARAGYEDEERRGVPLDAPHRNYKDANHKPELVCALTDFDGLCGFRAPAETADLLDGLGVASLKPYVDLLRAHPEDAALREVLTAILTADPEEMSHTVTETAAACDRLGGAYRPYADIAHHYPGDPGVLAAMLLNHVRLQPGEALYLGAGIPHAYLNGLGVEIMANSDNVLRCGLTPKHVDVPELLRIVRFEAGDPGILRPEASPDGEEVYDTPIDEFRLSRYVLPEGAGAHDLTLPTPQILLCTAGTVRAGEHELAPGRSVFVPAHEKAEVSGTGTLFRATVRV
214
C5YZJ2
1.11.1.7
ACT_SITE 78; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MSAGTRADEVVVQVRQLVVVVAVAVMATSCFSSSEAQLQVGYYNATCPAAESLIETIVHAAVRKDAGNGPGLIRLFFHDCFVRGCDASVLLDDPTGTPGNRTVEKTSQPNFPSLRGFSVINRAKRVVERRCPGTVSCADIVAFAARDAARIMGGIRFAMPSGRLDGRVSNASEATANLPPASFNLTQLLARFASKNLTADDLVTLSGAHSIGRSHCSSFANTRLYPQLDATLNVTLAARLRAKCPAAPGGKDRVVDLDFRTPLQLDNQYYSNVATHEVVFGSDQALGDRNDTAALVALYAANRKIWSQKFAAAMVKMGSIEVLTGPPGEVRLKCNKVN
14
A0A9R0J4V2
3.1.1.11
ACT_SITE 400; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MPYPKMSKILPFLILLLLSLSLNEALYNEKTVYNQIPAKILQNMISQACANVEDEINCLSNVESRLPNGPRNASSVLKAALETSLNEVQLALRKVSDFSSLSSSTAREQIAVEDCKELLDYSVTELAWSLSEMREIRVRGSVHDRGGDLQAWLSAAVSNQDTCLEGFEGTNQHVRNNIKGSLTQVTQLISNVLTLYTQLHALPFRPPRHNHYHNNNDTNKNNDQDYFPKWMTEGDKELVVSSSTSKGIHLDAVVSLDGTGKYRSINEAIDDAPNHSNRRHVIYVKKGVYNENVDMKKKKTNIMLMGDGIGATVISSNRNFMQGWTTFRSATFAVSGKGFIAKGITFRNTAGPKNHQAVALRVDSDQSAFYQCSMEGYQDTLYAHSLRQFYRNCNIYGTIDFIFGNGAAVIQNCNIYSRTPLPLQKVTITAQGRKSPHQSTGFSIQSSHIYANQPAYLGRPWKPFSRVVYMNTYMSATIQPKGWLEWYGNYALNTLYFGEYRNYGPGALLSGRVKWPGFHIIRDVSEATFFTVEQFIDGMSWLPATGVKFSAGLTN
125
Q89ZY4
5.4.99.12
ACT_SITE 52; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171"
MQRYFIYLAYDGTNYHGWQIQPNGSSVQECLMKALSTFLRRDVEVIGAGRTDAGVHASLMVAHFDHEDVLDTVTVADKLNRLLPPDISVYRVRQVKPDAHARFDATARTYKYYVTTAKYPFNRQYRYRVYGSLDYERMNEAARTLFEYIDFTSFSKLHTDVKTNICHISHAEWTKMEGEDTTWVFTIRADRFLRNMVRAIVGTLLEVGRGKLTVEGFRKVIEQQDRCKAGTSAPGNALFLVNVEYPEDIFSEETKKSVLSTLLPEGGEC
217
P19669
2.2.1.2
ACT_SITE 84; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000250"
MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRLREITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLGIKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQIIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK
52
W5N013
3.1.1.3
ACT_SITE 173; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 196; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 294; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
MIVRWTILAIYIATATDLGAEVCYDRLGCFGNDKPWAGTVERDISQLPWSPERINTRFLLFTRQNSNSFQDITAINPSTISASNFRSNRKTRFIIHGFIDKGEEGWVTDMCLEMLQVEDVNCICVDWKGGSRCPYTQAANNIRVVGAEVAYFGEVLQTQINYHPANIHIIGHSLGAHAAGEAGKRKPGISRITGLDPAEPYFQNTPIEVRLDPSDAAFVDVIHTDAAPMVPNLGFGMIQAVGHVDFYPNGGEEMPGCNKNAVSQILDFGFGLVSQIVDIDGIWEGTRNFVACNHLRAYKYYTDSIKQRDGFIGYPCSGYGQFQEGNCILCPSGGCPVLGHYADSYNPPVGAINQMLYLNTGDAAPYARWRYKVSVKLSGSRAVSGFINIALYTNEQYTRWLQIFRGKLEPAGTYTAGIDVEVNLGDLTNVKFLWDSSLFNPLQPTLGAETVTAQRGKDGKVFRFCGAGTVREEVLQTLTPC
128
E1JHB8
2.7.10.1
ACT_SITE 1094; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
MAMLPRLILLPLLLILRISWSDAVPLQQFSPDPDDSIENCGGENGAPLMTPCKSAIILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDNTEDPARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLVDSHNVVTARQYTDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGRYDPQRGFTIEIRSIVDGGDYYCRPNPPFPHNEEEMTSIEVRFIGNGHIDKDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDAPALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLALMGSPDELAPAAPRYVNGHIVPDIRIEELPDDYMEMSRDSDPDACTAIFSPTRLEGESSDFPDFSSETTFNFPGARQSPTLSNNLNSGSSKPLRKKNGMPTVDVADQAPEEIPMLHRSSTGSDGSPEQGRRFNQALKQQYVTPTPSPRHHVETKLNGEPSENYVNMKPPRKNIPGKTTTGGGGAAAGASTEAFSNPSYQPLSTVNEKEQRRY
97
M3WV69
2.7.11.25
ACT_SITE 242; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000556-1"
MEPLKNLFLKSPLGSWNGSGSGGGGGGGGGGWPEGSPKTAAYANPVWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIEGDDMDHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGAGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRLDEATWYLDSDDSSSLGSPSTPPMLNGNPPRPSPEPEEPRRPGPAERGSGSGTPKLIQRALLRGTALLASLGLGRDLQPPSPSPSPGGPGRERGEPSPMPRAPLPTPSAAEPPPSQLIRFSPKRPDAPPSPLSPDAPGPPTPAPLLLELGVPVGQLSAKSPRREEERRGSAVSPPPGISRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLSSPQPAPRRAPWTLFPDSDPFWDSPPANPFRGGPQDCRAQTKDIGAQAPWAPEAGP
105
Q551H4
2.7.11.1
ACT_SITE 195; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159"
MSDDKYHHDKHHDKHHIDSKQSTAAALSSSSTLASSSSMTTTTTTTSTTTTAASPITPKPRKNYPNSADQYELKETIGKGGSGLVQRAICLPFQENVAIKIIDLEHCKNVSLEEIRKEIQAMSLCHHPNVVAYHTSFVYNESLWVIMDFLSAGSCSDIMRFSFPQGFEEHVIATILKEALKAICYFHKTGRIHRDIKSGNILIDSNGNIQLSDFGVSATLIDTGETSRNTFVGTPCWMAPEIMEQVNYDYAVDIWSFGITALELARGKAPFAEYPPMKVLLLTLQNPPPSLEGDGESKWSHSFKDLVEKCLQKDPSKRPLPSKLLEHRFFKQAKKPDYLVQHILAKLPPLGQRYQMLSEDSFAMLRNTSSPQFDTGHSNSADEWIFPNENNDNNNSSTTTTTTTTTTTNPSNNNNNNNNKTKENLTQSPFETPSHTPSTSPGSTPSHSRTSTPTSNHTALGSSSTVVPPPVVPLTLPTAIPVTAAAYHQQQQHHHLSHSSGSIPNHNASSNLGASAHSNVHGLAHSSIHPTSSAASTTVVNNTQQPQTLQPPQQQHQLQQPIKTPSPINAINIVKLNQSDLITPPKTSPKKEGSIPSSSSHGNIPSLVTTSPKSPLQHQQQIPQQQQDPAMINSNNSSISSNGAYNRELISASGSALSKPPSPSSDKENNSTSKSNKSKSRQSSRASSLSESSDSTSHTSSSDEHSSRYESDRKSYKKKKSSSSSSNSKRDRERERDRDRSNKTYKNSRSRNVSRDRERERDRHNRSRDRDRERERERDRDRERDRDRSRDRSRDRSRDRERDRSRDRSRDRDRSRDRSRDRSRERDRDRSRDRSRDRSRSRDSDSRDRSRDRSRSHSNRRRSRSRDSRNKSRDRSSDSDRSRDRSRDRDYKSSKYKKSSRGTSGRKNNKIQSKLDSQATHISYLEDKISTLTNWLQQQNLLNTSNGQVLSPTDPNLVSKLQTQLDVLQSENSYLRNENINLKTIVNGSNSTNNSLNQSSGMAFRNSVSSLHQLNMSNSSNNSRPQTQ
99
A0A2C9UXM7
3.2.1.1
ACT_SITE 202; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 227; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"
MNFLSPLCVLSFLLFVFPSFISSQLLFQGFNWESCNKAEGWYNSLKNMIPDLANAGVTHVWLPPPSQSAAPQGYLPGRLYDLNASKYGTQDELVSLIDSFHQKGIKSLADIVINHRTAEKKDDRGIYCIFEGGTPDGTLDWGPSFICRDDTAYSDGQGNPDTGEDFKGAPDIDHLNPRVQIELSDWMNWLKTEIGFVGFRFDFVKGYAPSITKLYMEETLPEFAVGEKWDSLAYGQDGKPDPNQDGHRVALEDWIQAAGGAVTAFDFTTKGILQAAVQGELWRLKDSNGKPSGLIGLFPQNAVTFIDNHDTGSTQNLWPFPSDKVILGYAYILTHPGIPSIFYDHFFDWGLKEEISKLATIRNNYKIDSTSSVDILAADSDLYVAAINDNIIVKIGPKNDLGSLIPSNFQVVASGKDYAVWAKN
157
A0A061G1F5
1.11.1.7
ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MATLALNKLFLPIVFLVLIIEVSQSKAALDARYYDQTCPEAEKIILDTVRNASMHDPKVPARILRMFFHDCFVRGCDASVLLDLTPQNKAEKDGPPNISLQAFYVIDDAKAKLERACPQTVSCADIITIAARDVVAMEGKMEESPVQPKQLTYQRQLSTFRNSIQSFAKRGLGVKDLVALSGGHTLGFSHCSSFQARLHNFSSVHDIDPSLNSEFAETLRKKCPKPNKDRNAGQFLDSTATRWIVESFAKDQTLFFKEFAASMVKLGNVRVIENGEVRLKCRVVIKMRINMLASIILLEEVMPHPQT
14
A0A0A0LZD6
1.11.1.7
ACT_SITE 40; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MGFILFHVQKQNQSIVRNTVESYMNTDPTIAAGLLRLHFHDCFVQGCDGSVLISGNLAERNALPNLGLRGFEVIEDAKSELEAECPGIVSCADILALAARDAVDLSKGPSWSVPTGRRDGRVSSKSEAQNLPSPLESIAVHKKKFAEKGLDEQDLLTLLELKELCPNDGDATKRVALDKDSQFKFDLSFFNNIKDGNGVLESDQRLWNDDSTRSIIQKYISPLRGLLGLRFDYNFRKSMIKMSSIEVKTGMQVEIRRKCSRFN
14
H9G4Q2
2.7.10.1
ACT_SITE 802; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
MRDSLNIPLVHIFTLAAFSLAERLPKAPMIITPLETVDALVEEEATFECVVESFPQAEITWTRNNIPIRLFDTRYSIRENGQLLKILSVEDSDDGVYCCTANNGVGVTAENCGALQVKMKPKITRPPSNVKIIEGLKAVFPCTTMGNPKPSVSWIKGENVVKENTRIAILESGSLRIHNVQREDGGHYRCVAKNSLGTAYSKPVILEVEVFARILKAPESYNISFGSVVTLQCAATGIPTPTVAWLENGKAVSAGSIVETVKDRVIDSRLQVYVTRPGLFTCIATNKHSETYGTAKAAATINVSGIRLYKGDAGYCSTYRGEVCRALLAKDAFVFFNASYGDPEETQELLVRTALTELKTVSPLCRPAAESLLCHYIFQECNPSRTGPAPKPVCREHCLAVKDLYCFKEWLSMEENARRGIYKPGLMLLTLPECNRLPSLHQDPKACTWIPHLDLKKEDVTTTCYKGNGLTYEGSVNVTASGIPCQKWSEQVPHSHRKTPQAFPELSNAANHCRNPGGVNEQPWCYTKDASVKWEYCNVPHCGDEPLSEATTKPNELVPYYPSSFSPTYSMTVIISIICSFAMLIILAITVLICCRRRKQWKNKTRESVPPALTTLPSELLLDRLHPNPMYQRMPLLLNPKLFSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAFGDLNEYLRNRSPCNLCSLNDNNFEIGIRPSSPNMLTLSCTNQLYIAKQVAAGMAYLSERKFVHRDLATRNCLVGEDMVVKIADFGLSRNMYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFAFGLQPYYGMAHEEVIYYVRDGNILSCPDNCPLELYNLMRLCWSKLPSDRPGFASIHLILERMYERAVTADHNESR
97
Q9M2S4
2.7.11.1
ACT_SITE 472; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MSQTFAVILLLLIFLTHLVSSLIQDFSFIGFKKASPNLTLNGVAEIAPTGAIRLTTETQRVIGHAFYSLPIRFKPIGVNRALSFSTSFAIAMVPEFVTLGGHGLAFAITPTPDLRGSLPSQYLGLLNSSRVNFSSHFFAVEFDTVRDLEFEDINDNHVGIDINSMESSISTPAGYFLANSTKKELFLDGGRVIQAWIDYDSNKKRLDVKLSPFSEKPKLSLLSYDVDLSSVLGDEMYVGFSASTGLLASSHYILGWNFNMSGEAFSLSLPSLPRIPSSIKKRKKKRQSLILGVSLLCSLLIFAVLVAASLFVVRKVKDEDRVEEWELDFGPHRFSYRELKKATNGFGDKELLGSGGFGKVYKGKLPGSDEFVAVKRISHESRQGVREFMSEVSSIGHLRHRNLVQLLGWCRRRDDLLLVYDFMPNGSLDMYLFDENPEVILTWKQRFKIIKGVASGLLYLHEGWEQTVIHRDIKAANVLLDSEMNGRVGDFGLAKLYEHGSDPGATRVVGTFGYLAPELTKSGKLTTSTDVYAFGAVLLEVACGRRPIETSALPEELVMVDWVWSRWQSGDIRDVVDRRLNGEFDEEEVVMVIKLGLLCSNNSPEVRPTMRQVVMYLEKQFPSPEVVPAPDFLDANDSMCLDERSGSAGEFEDFVDSARFYSGPNETTTSSIFSFSGKTRTDPR
99
O14132
2.7.11.1
ACT_SITE 161; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MKKYLWGTPTTNTVFTGKQPKYTKEVRKCISIDEVYNVVRKVGDGTFGSVYLATTKTPSKEVVAIKSMKKKLAKVSDATRLREVHSLLRLSENENIVNIFDLYIDQFRCLHIVMEFLDCNLYQLISTRKNDPLTLEQVQDIMRQIFKGLNHIHTNGFFHRDMKPENILISSNSDSSSFNVKIADFGLAREINSRPPYTEYVSTRWYRAPELLLRDSYYSFPVDIYAAGCMAFEIATLQPIFPGNDDFDQLYKMCEILGSPDEQSQNTGDKGGGIWDRAELLANKLGISLPKMAPLDFGDLFSPPWNLAFASMLSQLLKWDPAKRPTAEMCLDLEFCRVSAPADAVASKEEVNKNTDFRVSISYFPSSSSIPDECNTEEESRINPSTSKFLKQLNKGFNGFTKPFRKSRKQSKNRKNKSSVATQFSEESEDIADSITSSTFFPVLPQIRPSTPLNLKLRNFIISSSEDSTSPKAKEFDRPLPSTEFLVAINKSQEALLNNSPNSKSGSTQLSASTCLSDLISPQLSILSHEDKRENQSVNSESSKYSPRSSNHSPTLHSKDLHRDMATVNNYAKSPPSFHATQDLLRKTLAYTNSSGTSTVLSNDSSAISSTFLDRDFPDFGITSLAGSLTLPDSKIIDRSKTHVSTQLLP
99
A0A1U8A5G1
3.1.1.11
ACT_SITE 413; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MLPKKVLILNTFINLPFLPPFAQKLPKLLAIFMASTLLRTFLLLSTIFIVRPWAVNSSSFSSATDTTLDAHLASIRSFCKSTPYPDACFDSLKPSISINIKPNIIGYALQSLQTAIFEADKLLDLFLNIGSLGVVEKQKGAIQDCKELHQITMSSLQRSLSRIRSGDARKLSDARAFLSASLTNKNTCLEGLDSATGPLKSVIVQSITSVYRHISNSLSMLPKQELRKVTEGSNRRLMGFPAWVSRKDRRILQSFDGDYNPNDVLTVAKDGSGNFTTITDAVNFAPNTSYDRTIIYIRAGIYQENLDIPSYKTNIVLLGDGADVTIITGNRSVGDGWTTFRSATVAVSGDGFLARDIKFENTAGPEKHQAVALRVNADLSAVYRCAIDGYQDTLYVHSFRQFYRECDIYGTVDFIFGNAAVVFQECNIIAKLPMPDQFNVITAQSRDTPEEDTGISIQNCSVLASDDLYSNIASVKSYLGRPWRIYSRTVYMESYIDNLIDARGWKEWSGNQGLDTLYYGEYDNNGPGSLADGRVTWPGYHIMNYNDARNFTVSEFITGDEWLESTSFPYDDGV
125
Q59WI0
2.7.11.1
ACT_SITE 249; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 266; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"
MSSEEILQGVEDIHLNTSSDSDSEYELEEETTTKSLPSSSRTITEKEDIVTKYADKIKTDPIKKGPKITKDRANRATVEQVLDPRTLRFLAKIINKGIISRINGCISTGKEANVYHGTSDDPDNDREYAVKIYKTSILVFKDRERYVDGEFRFRNTKNQSNPRKMVKVWAEKEFRNLKRIYQNGIPCPEPIELKSHVLVMEYLTKGDGQPSPKLKDYSFKDVQDIVNYYHKMLFYMRRLYQECRLVHADLSEYNSIVHKDNLYIIDVSQSVEPEHPMALDFLRMDIKNVNDFFSRSKINVYPERLIFRFITSEGHLLGIADNSDQELEKYLETLPLKTEDDQEVEDEIFRSLHLVRSLNNLDETDFQKFSEGKVDTMKDLVAMKEGEVASPGLQTANGNEVDSSEDEDNEGVSEEEEESSSEDDDDEEEEVDGISEKEWVEREQNAPRGKKYEDKDEKKARKEAAKLAKQEKRKTKMKKHIKKKIINKRKTGK
99
Q5MD89
2.7.10.1
ACT_SITE 1045; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028"
MKRDFTFFCRIWIGIPFFSGLVNGFSMSPPTLDNTKDQLVINANDTLNITCRGQRILDWSWPEESLSKVEFTDRQGQQSPTDTPGYREIRLKECQGVAGKPYCKILILTNAQANDSGYYRCFYKDIKAVIDGTTAASIFVFVRDPEHPFIKRGDNDMETIFITDSETHIEVPCLVSDPDLKVTLFSLVPYPEPVDGSVVTWNNKKGWSIPRHIIQNTSTFIGFYCSISVQNSQHTSSIYVVQVIGLKFYEFKLFPEDSPVELMQGESLVLNCTALVDFNTGVDFQWDYPGKKENRLASLQPLRNVLDEATEISSILSIRNIHLDDSGYYTCWANTLEMKRELTTVVIVHEKPFISLDYRNGSVIEAKEGQKSVRLSVKVSAYPSPEIQWYKNGKLISSKNSSRFKVQQHSLQIRDVCKQDAGEYMLVLKNSPAALEKRLNFTLIVNVPPQIHEKEAAPPTNLYGKGTRQILTCTADGSPPASISWQWRPWSPCDLERTRRALRRRGGRDQSPFCHNWMDLDPEHAVNPIESIDTLTQMVDGKEKTVGRVVIQNASVPAMYKCLAENRVGKDERLIYFYVTTIPEGFDIEMEPSEDPLEQDLVQLKCNADNFTYENLRWYRLDPQTVPPELDCKSLHQYATFLEGQLSFQTTSNNWVLQLNITNIQLQDEGNYVCEVQNRRTGVKHCHRKYIPVKAMEAPRYRHNPTNHTVNVSESLQMNCDVEGTPFPQLSWFKDNQPLHQISGILLQDSNRTLSIQRVREEDAGLYTCSACNQKGCVQSSATVSVIGSDDKTNVEIVILIGTGVIAIFFWVLLLVIFCNVKRVNPADIKTGYLSIIMDPGEVPLEEQCEYLPYDSSQWEISRDRLRLGKVLGHGAFGKVIEASIFGHDKKSSANTVAVKMLKEGATASEHKALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEYCKYGNLSNFLRAKREFFLPYRDRSPKTQSQVRRMIEAGQASQSEHQPSTSSTNPPRVTVDDLWKTPLTIEDLICYSFQVARGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDIYKDPDYVRKGNARLPLKWMAPESIFDKVYTSQSDVWSFGVLLWEIFSLGASPYPGIQIDEDFCKRLKDGTRMRAPDNASPEIYGIMLACWQGEPRERPTFPALVEILGDLLQENSLPEIPFNVSQSSEDDGFSQASSRPPSQEEIRLACNTLPTRYYNCVPFAGCVMVGPSSTCHSRVKTFEELPMEMTSHKTQHDSQTDSGMVLASDELERFEHKHRGAMLTTATTGQSTDRLISCPSVSSSGSGGGLLRPVFFTQLSGQTFYNNEYGHLSEEGVSDYFSSSDQAV
97
I1JK63
1.11.1.7
ACT_SITE 62; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MVKFTIVVIFLFFMFPIAFADLRVGFYSSSCPRAEQIVGQVVQRRFNRDRSITAALLRMHFHDCFVRGCDASILIDSTRGNQSEKAAGANGTVRGYELIDEIKKALERECPSTVSCADIITLATRDSVVLAGGLKYDVATGRRDGHVSQSSEVNLPGPRSTVSRVLEVFSANGMSLDEMVTLLGAHTVGFTHCSFFRDRLNDPNMDPSLRAGLGRTCNRPNSDPRAFLDQNVSSSMVFDNAFYKQIVLRRGVLFIDQQLALDTLSKGLVTVFAGNNAAFQRSFADAMVKMGNIKVLVGNEGEIRRNCRVFNSAS
14
Q5KF83
3.4.19.12
ACT_SITE 316; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 743; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"
MSCTHLQPSLHSLKPPSPSQQVHREECTLCFDGQDDPRGVVVCLSCFNGACLSPDRQHAHLHYQRTGHPLGMVIKRSRKEIRKRDSSEPPMKKLAISAPKDEEIWDYHTAFVCLACSSAGQEITAQEPKLEEMKTGIMTALSSAQQSEIKAWEEEILPCEHTLTLQQESVVVPGNVPSQCSSCDLTCNLWLCLTCGLANCGRQQFGGIGGNGHALKHFHETGHMLGVKLGTITPEGTADIYCYACDDAKIDPELATHLSTFGIEVMSQTKTEKSMTELQLEHNLKFDFSMVGDDGKELEPVFGKGLTGLRNLGNSCYMASVLQTLFSLPAFRSRYTTPEAFNHFQTCPNLLPASCIECQMLKLGDGLLSGRYSHVARLPPPTTHFEEQEAPKFQQGIKPTQFKALIGRGHEEFSTMRQQDSEEFLQHLLTRLRDEAKRQGRDEAAEPTEILKFAMEQRLQCGKCKRVGLQVEGVDLASLPVEAVEAGVSEDGKKLYEGVELETCLEQLCAEEAVAEYQCDHCKEKTTAYKSTKFKTFPDLLVLHMKKFQLVNWLPTKLDIPVSVPDMLTLDHLVAHGLQPGEEELTVSSSSPSLPEFNATAMAQLEAMGFPTVRCQKALLATGNSDAEIAMGWLFEHMEDPDIDAPIELGGSKAASNEPSQEQIGMIADMGFSHNQARKALRESDGNPERAIEWLFSNPGDPGEDAAPAGSAEPSIGGSSSLPAKYRLKAFISHKGPSVHSGHYVATIRQPQAGIEGEREEEGEWVLYNDEKVVRAASGGGEEMRGLAYLYVYERV
175
A0A804RDM1
1.11.1.7
ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MLMMTWTWTCNAKLLLMTLVFAAALSATVTTSRAQSPPLQYNFYGASCPQAEATVRNVTEGIIANDRTMGAAFMRLFFHDCFVRGCDASILLDPTSSNTQVEKKAIALRGYAAVNTIKAAVEAVCPGVVSCADILAFAARDTAVVSGGFAGFGMPSGRRDGVVSSFIEVLQNIPSPTFKLPDLVSNFAKKGLDVDDLVTLSAAHSFGQAHCSFVNGRLYPTVDPTMNATYAAGLKTVCPPPGSGGGDPVISNNRVTDPNALSNQFYSNLMTGQVLFVSDQQLMNTTYTAAKVANNSADSAAWMTQFQTALLKMGSIQVLTGTAGQVRKYCNVVNSS
14
A0A9R0JSY8
1.11.1.7
ACT_SITE 82; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MFPSVKQSKMAATKGFPLILVLSSLIIGLSQGQSTIPVVPGLSYTFYSSSCPGLDFIIRGHLWQIFQSDLTQAAGLLRLHFHDCFVQGCDGSVLLDGSASGPSEKEAPPNLTLRAQAFKIINDLRALVHQQCGRVVSCADITALAARESVFLAGGPFYWVPLGRRDGLNFATLSDTLANLPPPSFNTGQLLDSLANKKLNATDLVALSGGHTIGISHCTSFTDRLYPTQDPTMAQTFANNLKVTCPTATTNATTNLDIRTPNVFDNKYYIDLMNRQGLFTSDQDLYTDSRTKDIVTSFALNQNLFFQKFIDAMVKMGQLNVLTGTQGEIRANCSVRNANSNLHLKSVVEIDQEQQTLSQF
14
A0A8V0X6E7
2.7.10.2
ACT_SITE 738; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000632-1"
MAVWSVQGFLFLSGCRSCVRSVAPAPAPGTHQHQRCSGDLAAHSAPSHQDHSAMGFGPELWCPKGHSELLRLQDSELRLLELMKKWMSQRAKSDREYAGMLHHMFSQLEKQEGLGHLRATDHSSQIGESWWVLASQTETLSQTLRRHAEELAAGPLAKLSILIRDKQQLRKAFSEQWQQLSQEYARTTQQEMEKLKAQYRSLVRDSTQAKRKYQEASKDKEREKAKEKYVRSLWKLYALHNQYVLAVRAAALHHHHHYQRALPTLHESLYSLQQEMVLVLKEILGEYCSISSLVQEDVLAIHQEVAHAVEMIDPATEYSSFVQCHRYDSEVPPAVTFDESLLEETESLEPGELQLNELTIESVQHSLTSIEEELLASREAVSSKEQRVWELQAELRGEELALSPGERVHLLGKRQGLQEAQQQLQGLVCAQAKLQAQRDMLANKLAELGSEEPPPALPLQEDRQSVCSTDQERSGVTALETIKNHISGIFSPRFSLPPPVPLIPEVQKPLCQQAWYHGAIPRSEVQELLKCSGDFLVRESQGKQEYVLSVLWDGQPRHFIIQAADNLYRLEGDGFPTIPLLIDHLLQSQQPITRKSGIVLTRAVLKDKWVLNHEDVLLGERIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPELKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLSFLRSEGPHLKMKELIKMMENAAAGMEYLESKHCIHRDLAARNCLVTEKNTLKISDFGMSRQEEDGVYASTGGMKQIPVKWTAPEALNYGRYSSESDVWSFGILLWEAFSLGAVPYANLSNQQTREAIEQGVRLEPPEQCPEDVYRLMQRCWEYDPRRRPSFGAVHQDLIAIRKRHR
98
Q0TXL9
3.4.21.92
ACT_SITE 121; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 146; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086"
MSNRFGFGAPFPSHQEQRQSPQAFSPIPYVTESMGGGFKTSDIFSRLLQERIITLNGEVEDSMSAVVIAQLLFLEAENPEKPISMYINSPGGSVSAGLAIYDTMNYIRSPVSTTCMGMAASMGSLLLAGGEPGQRYILPHARVMIHQPSGGYRGKASDIADHAKEILRIRDRLNRIYQNHLTKERTLEEIEKYMERDYYMDAEEAVEFGIVDKIMEKRVVPGKDEDSN
179
A0A078FV88
2.3.2.26
ACT_SITE 849; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MTLRRSTAADSPISHRSPLAVAGTDNHKRKLDDYAADYSLDLLQKMKRHEVDADRISPASQQKPLTSGENYRSLYTPGECSSSSSPSSSSSLPESWTRSESTRLQLFVRMMSGGKTIVIHADRNDTVEHLHHRIQLKTQIPVTEQRVIYKGKQLQFEHTLSHYSIEHDSSLHLVGRMQSTEYPVACQTVDEIMSTISRMHRGENLYGGRTNINDKLVKFFARIPAESNRSSAKYLKIFSNSSVPAALVMLFVSPLEINKACGKSSIKLFLNSCVALPVHQQNSCLPVVLEFCRLLRGACPDNKLYASCRNTLGSMLDLVCKSDEFQFRLFTIGEEIYPCVTELADIIVRELVENTGPGLSEVQKFSSFWQPLKRAITAQLPCLFPVAMPLRNTVMEAEIGKLFQIFRRLMTVMDICMTRIESSLGNRGVANTEAMSATWSQYLAVLKIVDSMCELYQGAKEQLASLLNARKVSFSALVLKFAKRGDDDHQWIFDYKEATTFESRRHLAMLLFPDVKEDYDEMHEMLIDRSNLFAESFEYISGATPGSLHSGLFMEFKNEEATGPGVLREWFYLVCQEIFNPRNALFLRSADDFRRFSPNPASKVDPLHLSYFEFTGRVIALALMHKVQVGVLFDRVFFSQLAHPEISLEDIKDTDRVMYNSCKQILEMDPAFFDSNAGLGLTFELETEELGKRETVELLPDGRSIAVNSENREQYVKLLIKQRFAASISQHVERFSKGFSDILSDSVPAFFKRIYLEDFDGMLRGGENPISIDDWKAHTEYNGFKETDRQIDWFWKIMKKMTEEERRSVLFFWTSTKFIPVEGFRGLSSKLYIYRLHEANDRLPTSHTCFYRLCLPKYPTMGLMEQRLRFIAQDHVSSSFGKW
65
Q09298
2.7.11.1
ACT_SITE 338; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MSMKRFGKAAYRIANELVAKGGRLPIFQRFLPRIFPATYNLGVHVVLKKAPFPRQNALRIARLVTRHGRVFRPFSSVIIERHRFQNQNDWRRKFQPIRKELPRNVDLVERIRQIFGNSLRYNEDLKSTEWPNRIDSYEFGEFLGQGCNAAVYSARLANSDAESSGNTHYGAGFNEVTNILAEIPPVSKVAQKKFPLAIKLMFNFEHDRDGDAHLLKSMGNELAPYPNAAKLLNGQMGTFRPLPAKHPNVVRIQTAFIDSLKVLPDAIERYPDALHTARWYESIASEPKTMYVVMRRYRQTLHEYVWTRHRNYWTGRVIIAQLLEACTYLHKHKVAQRDMKSDNILLEYDFDDEIPQLVVADFGCALACDNWQVDYESDEVSLGGNAKTKAPEIATAVPGKNVKVNFEMADTWAAGGLSYEVLTRSNPFYKLLDTATYQESELPALPSRVNFVARDVIFDLLKRDPNERVKPNIAANALNLSLFRMGEDVKQMMEKCGISQMTTLLAGSSKVLSQKINSRLDKVMNLITAETIMANLAPHLISRAERQLRATFLSRMNREDIWRSLQYFFPAGVQLDTPATSSDCLETISSLMSSFSNDSENYEKQQKPAKNGYNNVPLLLRNVIRTDADGINGIVHRVRSK
99
O42130
5.6.2.2
ACT_SITE 806; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01384"
MELLDSPAPLRPLHDNPRLPKADGAQKRLSVERIYQKKTQLEHILLRPDTYIGSVETVTQQMWVFDEDVGLNCRDVTFVPGLYKIFDEILVNAADNKQRDKSMSCIKVTIDPENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACREYKKLFKQTWTDNMGKAGEMTLKHFDGEDYTCVTFQPDLSKFKMTILDKDIVALMSRRAYDIAGSTKDVKVFLNGKRLPVKGFRSYVDLYLKDKVDETGNALKVIHEEVNSRWEVCLTLSEKGFQQVSFVNSIATTKGGRHVDYVADQIVTKLIDVVKKKNKNGVGVKPFQVKNHMWIFVNSLIENPTFDSQTKENMTLQAKSFGSTCKLSEKFIKGAVGCGIVESILNWVKFKAQTQLNKKCSAVKHTKIKGVPKLDDANDAGSKNSIDCTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKMLNVREASHKQIMENAEINNIIKIVGLQYKKNYEDRESLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLEEFITPIIKVSKNKEEIPFYSIPEFEEWKSSTQNYNSWKIKYYKGLGTSTSKEAKEYFADMARHRIGFKYSGPEDDAAITLAFSKKKVEERKEWLTNFMEDRRQRNVHGLPEDYLYGKDTNYLTYNDFINKELVLFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKGAQLAGSVAEMSSYHHGEASLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPVDDNVLRFLYDDNQRVEPEWYMPIIPMVLINGAEGIGTGWSCKIPNFDIRETVNNIRCLLDGKEPLPMLPSYKNFKGTIDELGPNQYVISGEVSILDSTTIEITELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYKEYHTDTTVKFVVKMSEEKLAEAEAVGLHKVFKLQTNLTCNSMVLFDHVGFLKKYESPQDILKEFFELRLRYYGLRKEWLIGMLGAESAKLNNQARFILEKIDGKIVIENKPKKELIQVLIQRGYESDPVKAWKELQNKEEEEGDESGEESAAATGPDFNYLLNMPLWYLTKEKKDELCKQRDNKDKELEDLKHKSPSDLWKEDLAAFVEELDAVEAKQMQDEMAGITGKPLKVKGGKQGGKQKVTKAQLAEVMPSPHGIRVVPRVTAEMKAEAEKRIKKKIKSEKNESDEKQEGNSSGDKEPSSLKQRLAQKRKAEQGTKRQTTLPFKPIKKMKRNPWSDSESDSESDDFEVPSKRERVVRQAAAKIKPMVNSDSDADLTSSDEDSEYQENSEGNTDSDTTSKKKPPKAKAVPKEKKGKAPKEKPLPDAVPVRVQNVAAESASQDPAAPPVSVPRAQAVPKKPAAAKKGSTAKDNQPSIMDILTKKKAAPKAPRRAQREESPPSEATAAVAKKPGPPRGRKATKRLTSSSDSDSDFGSRPSKSVAAKKSKRDDDDSYSIDLTADSPAAAAPRTRPGRLKKPVQYLESSDEDDMF
222
C5XI24
1.11.1.7
ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKLSAAVLCALVAVQAAALLLATVPSAQAKELEVGYYGKKCKGVENVVKWHVIKAIKANRRTGAALVRLLFHDCFVRGCDGSVLLDASSDNPHPEKEAPVNIGLAAFDVLEEIKAAVEKRCPGVVSCSDILIYAARDAASALSNGHVHFAVPAGRLDGFVSKADEAQAELPDSTHDVQQLIDNFARKNFTVEELVILTGAHSIGQGHCSSFRGRLSEPSSQITPAYRDLLNYKCSQGSNPPVDNNVRDEDYDVVAKFVAGFTSRVRKIPDFLDNSFYHNNLAKIVTFHSDWTLLTHKEALGHVVEYAENGTLWDEDFSESLLKLSKLPMPAGSKGEIRKKCSVVNHRLY
14
Q9ZWC8
2.7.11.1
ACT_SITE 987; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MKQRWLLVLILCFFTTSLVMGIHGKHLINDDFNETALLLAFKQNSVKSDPNNVLGNWKYESGRGSCSWRGVSCSDDGRIVGLDLRNSGLTGTLNLVNLTALPNLQNLYLQGNYFSSGGDSSGSDCYLQVLDLSSNSISDYSMVDYVFSKCSNLVSVNISNNKLVGKLGFAPSSLQSLTTVDLSYNILSDKIPESFISDFPASLKYLDLTHNNLSGDFSDLSFGICGNLTFFSLSQNNLSGDKFPITLPNCKFLETLNISRNNLAGKIPNGEYWGSFQNLKQLSLAHNRLSGEIPPELSLLCKTLVILDLSGNTFSGELPSQFTACVWLQNLNLGNNYLSGDFLNTVVSKITGITYLYVAYNNISGSVPISLTNCSNLRVLDLSSNGFTGNVPSGFCSLQSSPVLEKILIANNYLSGTVPMELGKCKSLKTIDLSFNELTGPIPKEIWMLPNLSDLVMWANNLTGTIPEGVCVKGGNLETLILNNNLLTGSIPESISRCTNMIWISLSSNRLTGKIPSGIGNLSKLAILQLGNNSLSGNVPRQLGNCKSLIWLDLNSNNLTGDLPGELASQAGLVMPGSVSGKQFAFVRNEGGTDCRGAGGLVEFEGIRAERLERLPMVHSCPATRIYSGMTMYTFSANGSMIYFDISYNAVSGFIPPGYGNMGYLQVLNLGHNRITGTIPDSFGGLKAIGVLDLSHNNLQGYLPGSLGSLSFLSDLDVSNNNLTGPIPFGGQLTTFPVSRYANNSGLCGVPLRPCGSAPRRPITSRIHAKKQTVATAVIAGIAFSFMCFVMLVMALYRVRKVQKKEQKREKYIESLPTSGSCSWKLSSVPEPLSINVATFEKPLRKLTFAHLLEATNGFSAETMVGSGGFGEVYKAQLRDGSVVAIKKLIRITGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDEDFEARVSDFGMARLVSALDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKPIDPGEFGEDNNLVGWAKQLYREKRGAEILDPELVTDKSGDVELFHYLKIASQCLDDRPFKRPTMIQLMAMFKEMKADTEEDESLDEFSLKETPLVEESRDKEP
99
A8XU83
4.1.1.50
ACT_SITE 87; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 101; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 250; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 265; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MSATATICSEKNFAVQTHPVKAPDEEYFFEGAEKLLELWFCSTKGITDTSLRSIPRSEIDNMLDVARCKILHSKHNESIDSYVLSESSLFVSDNRVILKTCGTTRLLAALPVLMQLAGTYAGLDQVQSVYYSRKNFLRPDLQPNLHKNFDAEVEYLDSFFEDGHAYCLGSLKQDRWYLYTFHREVEFPANKQPDHTLEILMSDLDEEVLHKFTKDFAVDGKDCFMRAGIDKIIPAGADVHDELFDPCGYSMNAYINDTDQYATIHVTPEKEFSFASFETNQDLVCLYSQTRKVLQCFRPNKILMTVFANDISVKGKDAQQQLWDRELPGYRRTNVQFVRLETETLVYAHFVRKAPHDLTSSSDEDDGERSD
196
Q9HR29
5.6.2.2
ACT_SITE 130; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01897"
MSSESPDVPDDVADRVKNVRVDEEMEQSYIDYAMSVIAGRALPDVRDGLKPVHRRILYAMHESGVTSGSGHRKSSNIVGDTMGDYHPHGDSPIYDALVRMAQDFSMRYPLVDGQGNFGSVDGDPAAAMRYTEARMAPIAEELLTDIEKDTVAFQANYDDRLTEPAVLPSSFPNLLVNGSSGIAVGMSTNVPPHNLGEVIDATIHLIDTPDCTVLDLMEYVKGPDFPTAANIVGRADVKQAYQTGRGRVRMRAEYHVESNGRRDSIVITELPYQQNKSTLVERIADDVRDGKLEGITDLRDESDRNGVRIVIDLKQKANTDVVENRLLESHLEKTFSVINLALVDGEPKVLTLKELLAEYVSHRKEVVRRRSEHDLGEAEDRAHILDGRLTALENADEVVELIQDAEDRDAAKETLKSAFDFSQDQADHIVRMQLGSLTSMEAADIESEYEDVTARIERLEEILGSEQELLDVIKDELREIKTQYADERRTSFIEDTGTVADEDLIPEEDTVVVLSEGDYIKRVPAETFDAQHRGGKGIIGSDLKDGDRVSTVFTASTHDYLLCFTDQGQVYRLKVYQVPEMSRTARGTSAVNILDLDDGEEISAVVTADDLDFKADDEYLTMATRNGYVKRTSVGEFGNILSTGIIAIDLEDGDALADVEVTDGSHDVILGSEAGMAIRFDEGDVRAMGRNARGVRGMDLDAADRIAGVAAVESEDDRSLLTVTEFGYGKRTRVGEYRSQSRNGKGLVDIKTGDRNGDVVSVDAVGDDDSLVVMSADGQIIQMPVDEISTVGRNTKGVNIMAVGSGDEVAGVSVRAADQADGEE
222
Q3ZB95
5.3.1.8
ACT_SITE 294; /evidence="ECO:0000256|PIRSR:PIRSR001480-1"
MAEVKVFPLCCVVQNYAWGKAGLDSEVARLVLGGDPQAHIEHSKPYAELWMGAHPKGDALIKDNRISQRTLGQWIADFPGCLGSKVKDTFHGQLPFLFKVLSVNTALSIQAHPNRELAARLHAQFPEHYPDNNHKPEMAIALTQFEGLCGFRPMEEILGFLKNVPEFRALVGNEASEELQSADGNPHRTSLALKKCFTRMMNCEKKLFVDQLNMLVKRISEEEAAGKDTSGSNGELLLRLHSQYPGDIGCFSIYFLNRIVLQPGEAMFLGANEPHAYLSGDCVECMACSDNTVRAGLTPKYIDVDTLCEMLNYCPAPVSAKIFPCVRDNADPCVYLYDPPVPDFTVMRIQVPSSTQQYTVSALDSAGILLVIDGEAVATSAAALSDITLKRGSVLFISANESVSLQLTSSTGMTMFRACCLL
214
Q86IZ3
2.3.2.23
ACT_SITE 86; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133"
MAARLMKEYKVLQNEEFEDILLYPRDESDLYRWVAIIKGPPDTPYENGKFELDISVPTNYPLQPPTIKFVTKIFHPNIHFKTGEICLDLLKTSWSAIYTLQSVCRSIIALLSLPEADSPLNCDAGNLIRNGDVKGHDSLARMYTRLYGC
64
W1NL91
3.1.1.11
ACT_SITE 426; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MGVFQDYGHLTERGRVERQKRNKQKRVIVALTSAFAALALIIIAAFAVVSLNKHPEKAQEHQPVKISTSMKAIKSICSPTDYQEACVSSLSSAIKSNSSLTGPEDLIKAAIKVAKKEVIKAFDHASKLRKNARSQMEKEALSNCKELLSYAMDELDETFSGVSVAGLKDLATVSQDLKNWLSAVLTYQETCLNGLEDSNAKSDMAEAMKMATQLTSNSLAIITEASSVLSILKVPGFSRRLLSKENHFSEGKGGFPSWFPAGERRLLAMQEMTPNVAVAKDGSGDFRTITEALSKLPPAKERNGRYVIYIKAGVYDEQVTVTKEMVNVTMYGDGSRKTIITGSKNFIDGTPTFKTATFAAIGDDFMAKAIGFRNTAGAAKHQAVALRVQSDRAVFLNCRMDGNQDTLYAHAHRQYYRSCVITGTIDFIFGNAAAVFQNCQIVVRQPLPNQQNIITAQGRTDKRETTGVVIHKCKILPDKKLVAGSSTAKTRSYLGRPWKQYSRTVYMESTIGGFIEPEGWMPWDGDFALDTLFYGEYMNQGPGATLTKRVNWKGYRVLKSKEEAMAFTVDKFIQGGEWIKATGTAVRLGFFS
125
H2MBW3
2.7.10.1
ACT_SITE 826; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
MWILSVLVWLATLSCCRAAETPGPPLLRLNSTIMPNQSEMVMLAGSAFSVNCQGNRSVKWSSTGIHWSQREETKTVKSANPRHTGTYTCGYTDQSLEHLNTWFHLYIKDPSNPSTVFVTPRQKIITLMEGKSFLFKCLLTDPSVTNLTLQRMDGRPLPPGMNVTLNPKRGALIQDVQVSFRGQYSCSGWRDRKQFRSSPLQLEIRALPPPPTLSVSQNYFVRLEGEPFEVTCQAVNQNHFVNVTWTHRSVKELKISVSRQHINNQLIIRSTLTVSAVSRTHSGEFLCTAYNERGVTTASVQLLVLDSPSLHLYLYLLAPSDTSTLQVQEDQYANVSSMAAKAQAWPAANISNGSSAVKEKLIANITNEGNETVLNNSYKVEVHEGGDVWLTIVMEAYPPVNHQKWVTPAHMSSKDNTVFEESYTTSDYRSQATLLLRRVRQEDQGRYLFHFSNPFFNGSQDVNLLIYSFPTVAMTQQNQSLNCSSSGYPRPTVRWFICRGIQDSCMNDSSSPGIPGILTSQEEEEEEKEVSTLLPIPEEDRVLTVECTAFNLLGRSSQVFYHRPAKFHSIYTPVLIGAVSAAATLLLLLLVVLHKWRKKPKYEIRWKIIESTDGNNYVFVDPSQLPYNHKWEFPRDKLRLGAVLGSGAFGKVVEATAYGLGTDNKATRVAVKMLKPSAHSEERDALMSELKILSHLGYHNNIVNLLGACTQGGPMWMITEYCSHGDLLNFLRVHAQDFVASTMLTAEDGGGEPCYKNMAVQKSRLRSDSGISCCSEYQEMQPILSPGKTQMGLHTEGLSLCDLMRFSYQVARGLDFLSTRNCIHRDVAARNVLLTDQHVAKICDFGLARDIRNDDSYIVQGNARLPVKWMAPESIFQCIYTLQSDVWSYGVLLWEIFSLGKSPYPNVAVDANFYRRIKDGHHMEAPAFAPAEMYRLMTLCWSLEPTHRPNFKQIGELINRLLLSTCGSSGCHSPEPTYRNIDNCTEEEEVLEQTLKPKAAEESGHHDNRETRAEEIEKIYKQT
97
Q54PA0
5.3.1.8
ACT_SITE 314; /evidence="ECO:0000250"
MENNNNNNNNNNNNNNNNNNIVLLKCVSQNYEWGKYGSNSTVAKLLKGYAKECSDIIKETIPYAELWMGDHVSAPSKVEYKNKELKLREYIDTVQKEINEKSSTSSSSSSSIRGEIVEKRFGNDFPFLFKVLSIRTALSIQAHPDSQLAQVLFKKYPNIYKDPYHKPEIAIATTPFEALCSFRPLSEIQSFIDTIPEFKNSLPNNLIKLDDCKEYLKSIVTSLLKADGLLISNNLKELNNRLNEKREEERDDLDRLVLKLYSQYPGDVGVFFAYILNYIVLKPGEALFLGAGEPHAYISGDCVECMAPSDNVVRAGLTPKLKDVDTLGDMLTYRTGRPDLVVPQQRPDLSLTNYRCYQPPVDEFQVEYYHLDDCCKNINVYSSKGPSIVLVYSGNLSIENKSNQSTLNNLHTGSILFVPANTDYQFIQSDSSIPVSIYVASVSNRIFNKNNL
214
Q5NB11
3.2.1.14
ACT_SITE 114; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P29022"
MAKPTPAPRATPFLLAAVLSIVVVAASGAEARWYGGGGGGGYSPSPSPVSSIVSEQLYASLFLHKDDAACPARGFYTYASFVRAATRFPRFAATGCADARKREVAAFLAQISHETTGGWATAPDGPYAWGLCYKEEINPQSSYCDATDKQWPCYPGKSYHGRGPIQISWNFNYGPAGQALGFDGLRNPEIVANCSDIAFQTALWFWMTPRDTKPSCHQVMVGEYRPGPADVAANRTAGFGLVTNIVNGGLECNRAGDARVNNRIGFYRRYCQVLGVDVGPNLDCEHQQPF
158
I1N774
1.11.1.7
ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKLTTILIFFIFALPFTFANLRVGFYTATCPRAETIVGEVVQRRFSQDKSIVAALLRMHFHDCFVRGCDASILIDPTSTRTSEKIAGPNQTVRGFEIIDEAKAILEQACPLTVSCADIIALATRDAVALAGGIRYSIPTGRKDGLLADPSLVILPAPSLSVQGALQFFTARGLTLEDMVTLLGGHTVGFAHCSVFQERLSSVQGRVDPTMDPELDAKLVQICESNRPSLSDPRVFLDQNSSFLFDNQFYNQMRLRRGVLHLDQQLAFDSLSRDIVEDFAANDGTFQERFANAMIKLGSIGVLDGNEGDVRRNCRAFNIPL
14
A0A804JV12
3.1.1.11
ACT_SITE 358; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MATLLANLVILYFNFLLVLKVAANDPISWCNQTPHPKVCSSMLENEIAESISQSDFRDVLLRATTARTVLALRQISSMDMTLLDKPAKAALADCLKLYNDTIIRLQHSMRSSSSIEDSQTWLSAAKANERTCRDGFVELGSTFPLASSSFVTNHLSESLSNMLAVNIATPRDKPPPKNRRLLSDGFPRWVKAADRKLIQTGVTIKPDLVVAKDGSGNYKTISEAVAASVNLRQTTSRFVIYVKAGVYSETVDIALNMVNLMMVGDGKDDTIVTGSKNVVDGTSTFNTATFRVDGEGFIGQDMGFENTAGPEKHQAVALRSSADRSVFYRCSFKGYQDTLYVHTNRQFYRNCDIYGTVDFIFGDAAVVFQNPKIYVRKPMDRQKNTVTAQGRDDFHENTGIVMHAAFVMAAPDLKPVQGSFQTFLGRPWQQYSRTVYLLSRLDDLVDPAGWLAWNKTMSVSNLYYAEFQSKGDRADTSKRVNWPGYHVLTTDQEVEPFTAGKFLTGDSWIRATGVPYASGLYG
125
Q5BBL3
2.7.11.1
ACT_SITE 686; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MNNDSFSSFKFRRPSSKLHKDPPGYGSRALNSQQSTTSLKRHPSAPVYPRSSAAGSREHLRTRSNAYGSSSSSLDQNSAGASPVLGSSDSGHFHSSHSSRSRPPYSGRFSLNDQSSDELIGAPFDSRGMLSALEEHTAEPDNRSYQPPDPAERYTEKPPNFRSQTTPNPRALRQSASFTTLPPRMEAFPNAAGNDRPTNTKRFSDEATPVRPPGPSRSKKSSFSSFVNSMLGSPRGIKISAPENPVHVTHVGYDNQTGQFTGLPKEWQRLLQESGITQKEQEEHPQTMVDIMRFYEKNARGDDEVWHKFDHAYPQQPTAASPISQPAGSTTYGTQRTSPPTSPRFPQNHEGSFENPRAPPPIPRAAPIAAHAMSPPLGGLVPNRAPPKPPTAAANLVPSRPAPQPPTSSPYSNISTRPSPETQSPQFSTPPIPETEPLPSESQRSRSNSRTNGAQGPWPSVSPSHYQQQQEQAMAVAQQALANKQLERSRSQRQQQQSPRPDQMPIAQPALPQHAPSPEDVALTQASQTARAAPAARPRQRPRQSNAMDVRARLVAICTPGDPTKLYYNLNKIGQGASGGVFTAYEQHTNNCVAIKQMNLDLQPKKDLIINEILVMKDSKHKNIVNFLDSYLHGLDLWVVMEYMEGGSLTDVVTFNIMSEPQIAAVCRETLNGLQHLHSKGVIHRDIKSDNILLSLDGNIKLTDFGFCAQINDSQNKRNTMVGTPYWMAPEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALYLIATNGTPKIKDEHNLSPVFKDFLHFALRVDPEKRASAHDLLKHPFMNLCAPLNHLSPLVKAARISRAQEKAQKGGV
99
A0A8W4FN02
2.3.2.26
ACT_SITE 1549; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQSSMPENMTLQRANSDTDLVTSESRSSLTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDENSPANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNPAVMMGAEGMEGGAAGSQHSRKLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADHVSGYLQFRVEVTSSVHEEMLSSPSDASPEAVGTILGVNTVNGDLGSPSDEEDMPGGHHDSPVCSNGPVSEESADGTPKHSFRTSSTLEIDTEDLTSTSSRTSPPRGRQDSLNDYLDAIEHNGHSRSGAATCSERSMGASPKLRSSFPTDTRLNAMLHIDSDEEDHEFQQDLGYPSSLEEEGGLIMFSRASRTDDGSLTSQTKPEDIPVETEEASIHEPASFEDKPEHLPELTESSLPSGPMPDESENGLESQPGADQGSTELCGSQEVDQPTSGADTGTSDTSGGSRRAISETESLDQGSEPSQVSSETEPSDPARTESVSEASTRPEGESDLEGADSSCNESVTTQLSSVETRCSSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQDSICTPGSLPVVQVPSGEEEGPGAESATLPDQEEVGEVWQRRGSLEGAAAAAAAAESQPQEEGDAGEAQGACEGATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENSSALDGAGEEADFHQASADFRRESVLPHSTSRSRLTLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE
65
Q2FXI2
2.1.1.33
ACT_SITE 117; /evidence="ECO:0000250"
MRVRYKPWAEDYLKDHPELVDMDGQHAGKMTEWFDKTQPIHIEIGSGMGQFITTLAAQNPHINYISMEREKSIVYKVLDKVKEMGLTNLKIICNDAIELNEYFKDGEVSRIYLNFSDPWPKNRHAKRRLTYHTFLALYQQILNDEGDLHFKTDNRGLFAYSLESMSQFGMYFTKINLNLHQEDDGSNILTEYEKKFSDKGSRIYRMEAKFHSQK
45
G0HV10
6.3.4.2
ACT_SITE 391; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 517; /evidence="ECO:0000255|HAMAP-Rule:MF_01227, ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 519; /evidence="ECO:0000255|HAMAP-Rule:MF_01227, ECO:0000255|PROSITE-ProRule:PRU00605"
MPTEPETDYDPELGRKFIFVTGGVMSGLGKGITAASTGRLLKNAGFDVTAVKIDPYLNVDAGTMNPFQHGEVYVLKDGGEVDLDLGNYERFLDIDMTFDHNVTTGKTYQHVIEKERSGDYLGRTVQIIPHITDDIKRRIREAAEGNDVCIIEVGGTVGDIEGMPYLEALRQFAHEEDEDDILFTHVTLVPYSKNGEQKTKPTQHSVKELRSIGLQPDILVGRCSDKLDIDTKEKIALFCDVPTEAVFSNPDVDDIYHVPLMVEEEGLDQYVMEELDIATEALPEDERENRWRDLVTQNTEGEVDIALVGKYDLEDAYMSVHEALKHAGLEKNVDVNVQWVNSEKMNDHHADRMREADAIVVPGGFGARGTEGKIEAIRYARENDIPFLGLCLGFQMAVVEYARNVLDLDDAHSAELDEDTPHPVIDILPEQYEIEDMGGTMRLGAHETEIDANTLAATLYGGESCTERHRHRYEVNPEYIDDLEAAGLKFSGYAENRMEILELAPEDHPYFIGTQFHPEFRSRPTRASPPFVGLLEAVLGDDPHTVTTEEVSH
252
A0A1U8AWF3
1.11.1.7
ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MSSFRDFISSQMPTMLYCFICFLAISTMASGSTASLKVGFYSSTCPSAEAIVRKAVTKAISQNPGIGAGLIRMHFHDCFVRGCDASVLLDSTPGNDAEKSHPANNPSLRGFEVIDMAKAHIEAVCPQTVSCADIIAFAARDSAYKLGGINYAVPAGRRDGLISRSADIRANLPPPSFTAKQLEDRFAGKGLSLEEMVTLSGAHSIGVSHCSSFLNRLYNFNATHPQDPSMDPDYAAFLKTRCPPTSTAGSSLDPTVPLDVLTPNRLDNKYYKNLKNHHGLLTSDWTLMSSHSTAWMVRNNAKHPSAWASKFAAAMVHMGYIDVLTGTQGEIRKSCSVVN
14
Q9V3D5
2.7.12.1
ACT_SITE 324; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q92630, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MLDRCEMPIQLDNEKLRRDVRLSGSRLDLPQLCNGSRRLDGHNNHVAANENTVTTTSLNGNGNGNGNSNSNNNNNIGSPVSSSTTNSSNGGNERGSSTKSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTKGRKRSPGSKSLAHILHCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQPSASSRHRSCRMSSSSSSSGLNSVSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQPPSQSHGHAQSNGHLPDIKLSASDKYNSMQKVAVRSKITSSVSDLESVQQYSLHRIYGGVGSGSTHHVSSAATRKHLPGTGSGIVGAMSSKYGSSTLAHNHHNVTHHNASTATIATTTHHHHHHGGQQQQQSSSGASTMAMSHSQSTGDVSDRAIFGRA
107
P87050
2.7.11.1
ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSTISEVGPWELGLSLGSGGPNSSRLAKHRETGQLAVVKPIVGWSELTSSQQARIEGELVLLRLIEHPNVLQLIDVISAQEQLFVVVEYMPGGELFDCMLRKGSFTEQDTAKFLWQILCGLEYCHKLHICHRDLKPENLYLDAHGSIKIGEFGMASIQQPGKLLQTSCGSPHYASPEIIMGRSYDGCASDIWSCGIIFFALLTGKLPFDDDNIRSLLLKVCQGQFEMPSNISPQAQHLLYRMLDVDSSTRITMEQIREHPFLSCFVHPNISIPIISAPIQPIDPLIVQHLSLVFRCSDDPMPLYEKLASQSPLVEKTLYTLLSRHLHPPSSAAVDRNRAVVDDLLGTAASNGQQMDEEEIEQAINIPTLAPYPISYAAESVPRPATSASPFLTPVTTSGTFNYSFNATNPQSILQRPATTSSAVPQLPKSVTPGLAYPHDSSMLSSNYRPPSALSPRNFNVSINDPEVQLSRRATSLDMSNDFRMNENDPSIVGNLAASNFPTGMGPPRKRVTSRMSEHTGNRVVSFPRGSAFNPRVTRFNVGNEQFSNNIDNNNYNQPYANATMNNSRRLRTPSGERSMRADLSQSPASYDSLNVPKHRRRQSLFSPSSTKKKLSGSPFQPKRSFLRRLFSSEPSCKCVYASLVASELEHEILEVLRRWQLLGIGIADIIYDSVSASISARIKRQNSLNLKPVRFRISVLAEFFGSQAVFVLESGSSTTFDHLATEFQLIFEDKGFLDNLELSYFQASASRPVSRMSVSSSPFAVFRQRQSVQS
99
A0A8M9PT21
3.1.3.16
ACT_SITE 1057; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"; ACT_SITE 1059; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"
MSTCTLLLVSQAGCGLNESLQPCEPPLQTQSCRICRKSKPMGECLECFPSSDLCRCFGERMSFVESNITKYLESSAFFKSEHAEVNMPAELCFDHSEVSGQGDPKKEDQSLERAAESCAEQDTPIDQSTIKLHEVDGLCIENSRINGEFSDQSGSSGYSSLLDSCSEHSESFEASGSSVDLVEMSQNDELSITFDPSDQSEFSEHDEEQLTLSEVSLSDCESFQQDDSEQIVLPEMILDDCDSFEQHNEEPLDASEMSPDLYEFVSFHQDDEEIDLSEMSLVDQDAAEQEDLSDSFQQGHVEPNPLDPLDYETLSECDAEYQEQYRECENDSSEDNLSEQNYAVELDSEDCETSKPSEPNNQNKLDEYHATHFESPELCQDSKESKPSDHCVSLVDTQLMGQMDTADDGVLPNSLDDCTCPSGSFNSLSEEHQDCNQLSEHSESSVCFEALEQCTSCGSYFKKCDAREQCPPSVPTDNSERPHQSRPTESCLESSKTHSSFFHNSEVNKENLPNRSSRTNFKKPPESDAMFSGSMETFEARWLSQFLTDLLRHNEESLSHAAENRESNKEVETPGVIDLMQEVQPLDNPRKLCRKCEELEKGVCCNEESPQHSDLHSSVDISLDAVTTTAGSSDESSEEDYGDCLDGKSQSSSETDSFKSFIDESESFDIFPDQPCDKENLLTEDDEPLIQNVQPDEVNKNCDMYSQEKLDACEEACEIDSEELTERESSKTYAEAVAFGLPTESEQIHEVENDHNLPDLMDEGFMVYYEGKDNELCLQNEEIAEDQVSGVSVVDCYGLEGIENAFVSVSGDSTGLCAGEKTFQAADSSDSPDEESTLLENLANQNLTNRSENEGSVQDLRSADEIDVNGEFCPDFENEGAHGPCCGEIETSEDEETSLFGFEDLVGCSDESDDGEVIPTNDPQLSCTIEELSNTETSTPCVSDSLDTEPKDTSELLNSPAVGGLAEQTKPNEKLEELIHQVARSEASEQEAICKSDQKKTGEQCDSYEDSESSEDEEFSEDCDCEICVPPTDQVPAKPLLPQIKSKDVGKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGTVHQVYVLKRPHVDEFLKRMGELFECVLFTASLAKYADPVSDLLDKWGAFRSRLFRESCVFHRGNYVKDLSRLGRDLNKVIIVDNSPASYIFHPDNAVPVASWFDDMSDTELLDLIPFFERLSKVDNVYTVLKQQRTTS
144