Entry
stringlengths 6
10
| EC_number
stringclasses 260
values | Active_site
stringlengths 0
544
| Sequence
stringlengths 20
2.05k
| labels
int16 1
260
|
|---|---|---|---|---|
Q0U736
|
2.3.2.26
|
ACT_SITE 1815; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
|
MTAHKSSNLDRVTRSAARRSTGSADDNTPNPNPPPPPPPPPPTRAPASNRKRKTAPPSSSPEPEAEQEEEAPARSSRAKRTKVDSQKKHARSKKAKGKAAMSAAESVPTAPQEDVRLTSDSQSNNPTDEKMSTPQPSSARRKGARKNDGSRRNPKTPGNDADPDAPSTSLRSSRKANNAEEDTAMEDAPEEQEDETRPPGEDSDEDDEEGPGGRYDEDDDEDDDDDDDPFSSGFLGRNPHSLAALRQLTGMMSGTTQRLRGILEQLRSVDVTMQLVALQELSETTWLAIFAPDAYVKELVKLMQPNEFTGEENPEVMLLACRCLANLMEALPAATANIVYGGAVPVLCSKLLEIGFIDLAEQCLSTLEKISVEFPSSIVREGGLTACLTFLDFFATSTQRTAVTTAANCCRNIPEDSFPTVRDVMPVLENILNNNSDQKVVEQACICVSRIVQSFRHQESKLEELVSKGLLKAILRLLLPGSTNMIGHNIHTQFLQVLAYTAKASPTLSAELLKMNVVDTLYQILTGVSPPSGAEDVAAKIDSVVIMQALIHRPKDQVYETLNVICELLPDVPKDGLLYLDDLRDAGYPGNEPQPLSTENKQTSNEKRIELLEGCKPEVKRFAVILLPTLTDAYSSTVNLGVREKVLSAQLKMLSNLDTDILEEALRSVPYASYLASIFSQQDHPSLVTYALQAAELLLKRLESIYRYQFYREGVISEISHLANRPSRTPEVQTKPKTTLEIEEAAESAPSSSSSGGDLDMEQEPIQDVEIETQSEDGDDDDGENEGRIETHDMQDDDDDSDSSSSSDRPEPPVVQNIEDIITLRAKKFLEVHEKDSDKPIRDKASAVLEDLKSLAKEIRGCIQEGTQSKCTELFTRLANYFEGDALDSITSYELKSSKIVDVLLEVFSTASPLSSVDHRAIFLEVFMGRSSQAKIKTASSASPATPFSSLVNKLQDLLSRSEHFEVFTVHQHAHDGRGGATSMLAKQLRLKLVADEDSGIPKSYRNIMVSIHAIAMFKALDDYLRPRISASERPRGSRTRDQFAAYAQALAEGRAPPPPHTPTDSTSRQAKKAAKSKSSPSDDSQAGPSSATRDKTRRSSRRQQNQLPPPPPPPPVIPRSNDDQDQVECADEERLSDDESMADTSALNAIVDDLEEELDEDTHDPSAVSVEVAPTGKATARKEDGTRISTPVQGTPMAKPPSETRTPSSRLSALLQDSALQRLGNAASALSYAAAVQSTPQDWHIEFSVNDQPISNDTTIYRAVHFSQSQPPEIAHRTVWNAVHTIKFKRVQGPPPTESSSLTPPPESASEASGMPASLDQHPVTSGILRLLSILHGLNAHLDDILSDNKDQIKHNAEPLSQFVNTKLTAKLNRQLEEPLIVASNCLPTWSEDLARFYPFLFPFETRHLFVQSTSFGYSRSMTRWQNSQPANDSRRDRHRDERPFLGRLQRQKVRISRSRILESAMKVMQLYGSSTSLLEVEYFEEVGTGLGPTLEFYSTVSREFSKKKLKLWRENESSEGEYAFGKRGLFPAPMSAAEAASINGERRLELFKTLGKFVARSMMDSRIIDVSFNPTFFRIGDSDTTVLPSLGAIKSVDEGLAKSLNLLKQFADAKYLVDTNDSLTSAEKTQALKDILVQDCRVEDLALDFTLPGYDTIELIDNGANTAVTINNVDKYFEHVLDFTLGSGVQRQVDAFRVGFSEVFPYSALKAFTPDELVMLFGRTDEDWTLETLMDSIKADHGYNLDSKSVRNLLQTMSEFKDQQRRDFLQFITGSPKLPIGGFKNLTPMFTVVCKPSEPPYSSDDYLPSVMTCVNYLKMPDYSTVDILREKLSVAIREGQGAFHLS
| 65 |
Q6YRX0
|
3.5.4.5
|
ACT_SITE 58; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1"
|
MVDICWEQLHRSAIEVRQNAYAPYSHFLVGAAGLVDDGRIVVGCNVENASYGLTLCAECGLVSHLIATGGGRLLAVVCVDSQDNYLAPCGRCRQVLLEHGGKELQVMTPTGPLSMAELLPWSFGPQDLRRIGGLNTNP
| 187 |
H3G9Y3
|
2.7.11.23
|
ACT_SITE 126; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1"
|
MERYDRGDVLGEGTFGIVFAAVQKSTGRRVAIKQFKRGKFKDGVDFTALREVKLQAELKHVNVVELLDVFVANDTMNVVFELLPSNLDDVIKDKAVVLTAADIKTYMQMLLKGLAYCHAHYVLHRDLKPENLLIGPDGNVKIGDFGLARVYGSPNRNMTSMVCTIWYRPPELLFGAREYSGSVDMWGAGCIFAELMLRMPYLTGLNELDQLGKIFHALGTPTDDEWPGVSSLANFVEFTPSTAPPLASIFSAASEDALDLLAKLLKYNPAERITAADALKHPYFSNSPAPTPTEKLPSTPAQPQT
| 103 |
W1NH90
|
3.1.1.11
|
ACT_SITE 165; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MLRKEWKVASDGSGDFGSVQEAIDAVVPLCNKQRIVINVMPGVYKQPLYVAKTKNLITLRGFSPEHTILTWDNTATNIRHHQASRVIGTGTFACGSVIIEGEDFIAENITFENSACEGSGQAVALRVTADRCAFYCCRFLGWQDTLYLHYGKHYLRDCYVEGSVDFIFGNSTALLEHCHVHCKSPGFITAHSRKSPQESTGYVFLRMVEVLIVDIRDMSEKDKLFYFLDGLQPWVEVELQRCDVQDLASAQAAAGQLVDYSRKEERSGKSKPAKPFKGKDATEKMEENDF
| 125 |
Q7SFL7
|
2.3.1.225
|
ACT_SITE 487; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000250|UniProtKB:Q8VDZ4"
|
MASEEGPSRSASPTNVDNTFPQYPPRAELTVAGPPSLISSRMTDIGTEDGQGSDTTPRGGGPSSANPNRRSGFYSDTQSRPETSGTGLSSRGPWAQSVPLRQQLTGKRGSIAGSIGSAGGRPISAASRSHVPSLTSHGFFRPMSSQKLQAQRGAGRPPTMNRPYVITGEAGARNSVISTGSGRIGAQIAEDAELRMPSRGTEMTEQETMERMTANTSPINGFFPTSSVTDSVRPLQSPVDARNINVEMNKDYREESPTTPPRSPTRTSRSFRSSFLMPRMNESGITGSNREIEGGEKLQSAASSPNIPPQSYERQRARFKRRAKRQNRANLGKNYEYFEGNTVFCLGGRFQNTKQRPINIATGSLIVLPCILFFIFSAPWIWHNISPAIPVTFAYLAYICVSSFLHASASDPGILPRNLHKFPPPEMEDSPTGPPTTDWVLVHSAEASTAAMEVPIKYCKTCQLWRPPRAHHCRLCDNCVETQDHHCVWLNNCVGRRNYRYFFTFVSSATVLALYLIGACLAQILVYKNQHHISFGHAVNHFRVPFAMVFFGFLTFLYPAALTGYHIFLMARGETTREYLNSHKFPKSDRYRAFTQANWLKNWFVVLCRPRPPTYYGFKVKYNQGDQRLGSHRRWQQPAVSDSKEGMEMQNVSPQLPQTGFMGPTALRNSNNGSTAEVRA
| 57 |
O74789
|
3.1.3.16
|
ACT_SITE 114; /note="Proton donor"; /evidence="ECO:0000250"
|
MTDLDLDWQLEELENGRLIPESNVVELCQRVRDILIEESNIQWISSPVTICGDIHGQLHDLLELFRIGGSCPGTKYLFLGDFVDRGFYSVETFLLLLTLKCKYPKEMTLIRGNHESRQITQVYGFYDECVRKYGSANVWRYCCEIFDYLSLGALVDGKVFCVHGGLSPSISSIDQIRLLDRKQEVPHEGAMCDLLWSDPEDISGWGLSPRGAGFLFGADVSEVFNRANDLSFIARAHQLVMEGYKIHFSDKDKQYPKFTNEEDSELDSDSASPVDDSPAPGDIITIPEKDKGSVVTVWSAPNYCYRCGNVASILQLDENQTQSFKIFGTASQERSGIPTKRPIADYFL
| 144 |
P10741
|
2.7.11.1
|
ACT_SITE 205; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
|
MPSPIPFNSFLPLELSPSADLRPCSSPVVIPGKDGKAFLGGTPSPRTRRLPPRLAWCSIDWDRLCLLQPLGSGGFGAVYKATYHGVTVAVKQVKKSSKNRLASRQSFWAELNVARLQHDNVVRVVAASTCAPASQNSLGTIIMEYVGNVTLHHVIYGTRDAWRQGEEEEGGCGRKALSMAEAVCYSCDIVTGLAFLHSQGIVHLDLKPANILITEHGACKIGDFGCSQRLEEGLSQSHHVCQQGGTYTHRAPELLKGERVTAKADIYSFAITLWQIVMREQPYLGERQYVLYAVVAYNLRPPLAAAIFHESAVGQRLRSIISCCWKADVEERLSAAQLLPSLRALKENL
| 99 |
Q54EY4
|
2.7.11.1
|
ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159"
|
MNSDSVENLFISRISKDDPEAIFQIVEVVGSGSFGTVCACRWMKKKDRESNGNRLIACKFVEVNADDVETNLNLVKEIDILKESMDCPYIVEYKGCYLKSSMLLIVMEYCKGGSLLDIIELCGKRLIEEEIAAVCAGVVKGLVYLHSKRTTHRDIKAGNVLLDEEGLPKLADFGVSTIAEQGQKMNTVIGSPYWMAPEIIMGQGYDQKADIWSLGITAIEIAELVPPRFDVPPSRVIFTIPHQPPPSLKIPSDWSPEFNDFVKQCLSMNPALRPSAQQLLSHPFILKGSSQQILQKLVNESIPLLKEKRAEKIRQLEEQEQQRNSSGSKMVSSVPTRASQALTNVRNAESLKGSVVILNSNTKTASIMRNKNPQPPPPSHSSGAGGAAGSTRRVPGNKSVLNRYPPANNVSNGTIAPSPINNNNNNNNTTTKVGKVSSPFLQQQQQQQQQNNNKNPPPKPTTPSPNKKIGDNISKTTPTTPTTTQPNTSTTTKTGSSLNIKPTNNVNRSTISIGQQKSPLQSSEREASYDEESVSVIYHGSEDEEDEEEFNHEDYEEINVNI
| 99 |
Q9NVE5
|
3.4.19.12
|
ACT_SITE 50; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 305; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"
|
MFGDLFEEEYSTVSNNQYGKGKKLKTKALEPPAPREFTNLSGIRNQGGTCYLNSLLQTLHFTPEFREALFSLGPEELGLFEDKDKPDAKVRIIPLQLQRLFAQLLLLDQEAASTADLTDSFGWTSNEEMRQHDVQELNRILFSALETSLVGTSGHDLIYRLYHGTIVNQIVCKECKNVSERQEDFLDLTVAVKNVSGLEDALWNMYVEEEVFDCDNLYHCGTCDRLVKAAKSAKLRKLPPFLTVSLLRFNFDFVKCERYKETSCYTFPLRINLKPFCEQSELDDLEYIYDLFSVIIHKGGCYGGHYHVYIKDVDHLGNWQFQEEKSKPDVNLKDLQSEEEIDHPLMILKAILLEENNLIPVDQLGQKLLKKIGISWNKKYRKQHGPLRKFLQLHSQIFLLSSDESTVRLLKNSSLQAESDFQRNDQQIFKMLPPESPGLNNSISCPHWFDINDSKVQPIREKDIEQQFQGKESAYMLFYRKSQLQRPPEARANPRYGVPCHLLNEMDAANIELQTKRAECDSANNTFELHLHLGPQYHFFNGALHPVVSQTESVWDLTFDKRKTLGDLRQSIFQLLEFWEGDMVLSVAKLVPAGLHIYQSLGGDELTLCETEIADGEDIFVWNGVEVGGVHIQTGIDCEPLLLNVLHLDTSSDGEKCCQVIESPHVFPANAEVGTVLTALAIPAGVIFINSAGCPGGEGWTAIPKEDMRKTFREQGLRNGSSILIQDSHDDNSLLTKEEKWVTSMNEIDWLHVKNLCQLESEEKQVKISATVNTMVFDIRIKAIKELKLMKELADNSCLRPIDRNGKLLCPVPDSYTLKEAELKMGSSLGLCLGKAPSSSQLFLFFAMGSDVQPGTEMEIVVEETISVRDCLKLMLKKSGLQGDAWHLRKMDWCYEAGEPLCEEDATLKELLICSGDTLLLIEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSSWGRVWRATSSQGASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFLEFGVPSPAHLRAWTVERKRPGRLLRTDRQPLREYKLGRRIEICLEPLQKGENLGPQDVLLRTQVRIPGERTYAPALDLVWNAAQGGTAGSLRQRVADFYRLPVEKIEIAKYFPEKFEWLPISSWNQQITKRKKKKKQDYLQGAPYYLKDGDTIGVKNLLIDDDDDFSTIRDDTGKEKQKQRALGRRKSQEALHEQSSYILSSAETPARPRAPETSLSIHVGSFR
| 175 |
F1SRY5
|
3.4.19.12
|
ACT_SITE 352; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q86T82, ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 909; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"
|
MSPLKIQGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLNAVAMKPSQGSGSFGAILGSRTSQKETHRQLSYSDNQVSSKRGSLETKDDIPFRKVLGNPGRASIKTAAGSGITATRTIPSLTSTSTPLRSGLLENRTEKRKRMLSSGSELNEDYPKENDSSSNNKAMTDPSRKYLTSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAASKDYSPSSTNLDRTNISSQTPSAKRSLGFLPQPAPLSVKKLRCNQDYTGWNKPRLPLSSHQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALISRRFAHLLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVPGEENSPDVTATRVYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKCALVRHKFNRLPRILILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKPPFNLGWSAQMAISRPLKASQMVNSCITSPSTPSKNFTFKSKSSLALSLDSDSEDELKRSVALSQRLCEISSSEQQQEDLEKDSKSCKLEPDKSELENSGFDAMSEEELLAAVLEISKREASPSPSHEDDDKPTSSPDTGFAEDDIQEMPENPDPMETEKPKTITEPDPASFTEITKDCDENKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELSLQEFNNSFLDSLGSDEDSGNEDVLDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEASVQSDRDRSGYIFFYMHKEIFDELLETEKNSQALSMEVGKTTRQAS
| 175 |
P9WPT1
|
7.2.2.10
|
ACT_SITE 301; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250|UniProtKB:Q5ZWR1"
|
MTRSASATAGLTDAEVAQRVAEGKSNDIPERVTRTVGQIVRANVFTRINAILGVLLLIVLATGSLINGMFGLLIIANSVIGMVQEIRAKQTLDKLAIIGQAKPLVRRQSGTRTRSTNEVVLDDIIELGPGDQVVVDGEVVEEENLEIDESLLTGEADPIAKDAGDTVMSGSFVVSGAGAYRATKVGSEAYAAKLAAEASKFTLVKSELRNGINRILQFITYLLVPAGLLTIYTQLFTTHVGWRESVLRMVGALVPMVPEGLVLMTSIAFAVGVVRLGQRQCLVQELPAIEGLARVDVVCADKTGTLTESGMRVCEVEELDGAGRQESVADVLAALAAADARPNASMQAIAEAFHSPPGWVVAANAPFKSATKWSGVSFRDHGNWVIGAPDVLLDPASVAARQAERIGAQGLRVLLLAAGSVAVDHAQAPGQVTPVALVVLEQKVRPDARETLDYFAVQNVSVKVISGDNAVSVGAVADRLGLHGEAMDARALPTGREELADTLDSYTSFGRVRPDQKRAIVHALQSHGHTVAMTGDGVNDVLALKDADIGVAMGSGSPASRAVAQIVLLNNRFATLPHVVGEGRRVIGNIERVANLFLTKTVYSVLLALLVGIECLIAIPLRRDPLLFPFQPIHVTIAAWFTIGIPAFILSLAPNNERAYPGFVRRVMTSAVPFGLVIGVATFVTYLAAYQGRYASWQEQEQASTAALITLLMTALWVLAVIARPYQWWRLALVLASGLAYVVIFSLPLAREKFLLDASNLATTSIALAVGVVGAATIEAMWWIRSRMLGVKPRVWR
| 258 |
H2LSD3
|
3.2.1.52
|
ACT_SITE 333; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
|
MKVMRAVNTKQCAPIIYALLQLIIFYAGLNAVKGVWPLPHALTSSVEQYPLNPQTFAFDYGKHSATQQGCSLLDAAFRRYFLLIFPDYTAENGQLEVAANNSFSLYISTDHNDCENYPNDDSSERYNLSVSAGQASLNAATVWGILRGLETFSQLVYQDDLGSYFVNETFIEDFPRFQFRGVLLDTSRHYLPVHAILKTLDAMSYSKFNVFHWHIVDDPSFPYQSRSFPELSKKGAFHPATHIYTQSDVRRVISYARMRGIRVLPEFDSPGHTGSWGKGQSHLLTPCYKGGAPSGTFGPVNPALQSTYQFMASFFKEVTSVFPDSYIHLGGDEVDFSCWRSNPHVRAFMQKMGFGGDFPKLEAFYIENIVNITSANNKTSIVWQDVFDYHERRSALSVVEVWKHGCYLCKVRQVTKAGLRVILASPWYLDLPGPTHNWARYYTVWPLAFPGSEKQKRLVIGGEVCMWGEYVDATNLFPKLWPRASAAAERLWSDEKQTSSVEKAFPRLEDFRCKLLRCSTFSNSNSTFFEACFCDSFFYLLSSFTCFLEFVFLGVESKQGLSMWDIANTNIKVFEDEQNFTFRSIQIIKYNV
| 170 |
K7KJ86
|
1.11.1.7
|
ACT_SITE 29; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
AEDIITEQVKLLYKRHKNTTFSWLRNIFHDCVVQSCDASLLLDSTRRSLSEKETNKNFESRNFRYIETIKEALERECPRVVSCADILVLSTRDGIKDQSIFSVGISPHILLKTGRKDGRKSKTNVVELFRPNHNKSIFVVLDKFGAIGIDTPSIVALLGTIHSPLTHPCTYIYEMTIRIKHT
| 14 |
B3S4K8
|
5.1.3.3
|
ACT_SITE 153; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 278; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
|
MKTSQYHTAHAVFINSKQNSFFYREGNSIDVALGYDGIEGYCKDNVYLGCVVGRVANRIAKGQFTLDNKQYQLAVNNGPNHLHGGPNGFSKAIWSAEQSTNDSVTFKYVSVDGEESYPGQVSVTVTCTLRGSEIILDYAATSLEPTPINLTNHTYFNLGGHDSGDIRNHIIQINSEYYTPLDDVQIPTGEITSVKGTPFDFMSPKPIGKNMPEGGYDHNFCLAECTGPCIRVTEPNSGRILEVFTNQPGVQFYTANYLNGIEGKGGAVYNKHSGFCLETQNYPNAINQDNFPSCVIRPGGPDYKHRTVYKFCNIN
| 211 |
A9A2U7
|
3.4.25.1
|
ACT_SITE 13; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_02113"
|
MSNNVEEKILHGTTTVGIKAKDGVVLCADMRASAGYFIANNNTMKIQKIDDHAGLTLAGGVADAQNIVDILRYHSNLHRVEKHGPISIHSLARLCSLIFHQNRGYPFMADILVGGYDAEGPALFNIDMFGSVEKKAYVTTGSGSPVAYGLLEEEYREDLTVEEAKKIALRAVKAAIVRNIGTGDGINIAIMDKDGFRLLTEEQKKAVIEL
| 180 |
P06800
|
3.1.3.48
|
ACT_SITE 842; /note="Phosphocysteine intermediate"; /evidence="ECO:0000250"; ACT_SITE 1157; /note="Phosphocysteine intermediate"; /evidence="ECO:0000250"
|
MTMGLWLKLLAFGFALLDTEVFVTGQTPTPSDELSTTENALLLPQSDPLPARTTESTPPSISERGNGSSETTYHPGVLSTLLPHLSPQPDSQTPSAGGADTQTFSSQADNPTLTPAPGGGTDPPGVPGERTVPGTIPADTAFPVDTPSLARNSSAASPTHTSNVSTTDISSGASLTTLTPSTLGLASTDPPSTTIATTTKQTCAAMFGNITVNYTYESSNQTFKADLKDVQNAKCGNEDCENVLNNLEECSQIKNISVSNDSCAPATTIDLYVPPGTDKFSLHDCTPKEKANTSICLEWKTKNLDFRKCNSDNISYVLHCEPENNTKCIRRNTFIPERCQLDNLRAQTNYTCVAEILYRGVKLVKNVINVQTDLGIPETPKPSCGDPAARKTLVSWPEPVSKPESASKPHGYVLCYKNNSEKCKSLPNNVTSFEVESLKPYKYYEVSLLAYVNGKIQRNGTAEKCNFHTKADRPDKVNGMKTSRPTDNSINVTCGPPYETNGPKTFYILVVRSGGSFVTKYNKTNCQFYVDNLYYSTDYEFLVSFHNGVYEGDSVIRNESTNFNAKALIIFLVFLIIVTSIALLVVLYKIYDLRKKRSSNLDEQQELVERDDEKQLMDVEPIHSDILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKDARKPHNQNKNRYVDILPYDYNRVELSEINGDAGSTYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFKDIVVTINDHKRCPDYIIQKLNVAHKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAEGKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHSCLHNMKKRDPPSDPSPLEAEYQRLPSYRSWRTQHIGNQEENKKKNRNSNVVPYDFNRVPLKHELEMSKESEPESDESSDDDSDSEETSKYINASFVMSYWKPEMMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELVNGDQEVCAQYWGEGKQTYGDMEVEMKDTNRASAYTLRTFELRHSKRKEPRTVYQYQCTTWKGEELPAEPKDLVSMIQDLKQKLPKASPEGMKYHKHASILVHCRDGSQQTGLFCALFNLLESAETEDVVDVFQVVKSLRKARPGVVCSYEQYQFLYDIIASIYPAQNGQVKKTNSQDKIEFHNEVDGGKQDANCVRPDGPLNKAQEDSRGVGTPEPTNSAEEPEHAANGSASPAPTQSS
| 149 |
Q2FW37
|
5.4.99.12
|
ACT_SITE 51; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171"
|
MRILVEIAYQGNNFLGFQIQQNGRTVQQQFEKLLQRMHKRHVRIHPSSRTDRGVHAIQQYFHFDTELNIPMSQWQYAMNRTLPDDIYVNNVVTVDDDFHCRYDCVGKRYRYKVYQAQHRDPFQSGLKTFIPETLDLGKMNRAAQQFIGTHDFTGFCSQKTEVESKVRTLYQSEIVKTDDGFDYIVTGSGFLYNMVRVLVAFLIEVGKGRHEVSDVPKLLESKNRKNVPFTAPAEGLYLEKIYLDENELLKDFGNDIKIHRKKSLQND
| 217 |
I1HER4
|
1.11.1.7
|
ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MSGARSVVVLRQFPASVLVLAAWIVFSVASSEAQLEVGFYNSTCPRAEKLIRTVVRAAIRRDPGNGPGLVRLFFHDCFVRGCDASVLLDDVPGSTGTVEKMSQANNPSLRGFGVIGRAKRVVERRCRRTVSCADILAFAARDASFVMGSGIGYYDVPAGRRDGRVSNVSEVLNNLPPSFFNASQLVASFAAKNLTADDMVTLSGAHSFGRTHCATIAFRLFPRLAADMDVSYGRFLRRRCPAATGGRRDPVVELDPVTTLLLDNQYYNNVVAGKVPFTSDATLLTRNDTAALVGLYAGNRTLWATRFADAMVKLGNLDVLTGDQGEIRKFCNRVN
| 14 |
P34635
|
2.7.11.1
|
ACT_SITE 158; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
|
MSNSQKPPSLQPNEIIKRTKPDYNWKVIVELGKGGYGTVNKVIKVNEEGFAIDDKEYAMKTEQKFASKHSSRLKIERNVMASYSKCDAQCKEHFPELIDFGQSPVWKWIVMTIVGPSLEELKMKYKPSDIPPSTILQCGLQTMKAIHDFHQIGFLHRDIKPANYCIGYGSKSETIYVLDFGLARKYRLPEWYCSRASHRCEELGRRDDYESWFFMFIDLVDTTLIDWKGLTRPDAYAKKQELFTKLKTYEKEPMFKVISIYLDTLVYDSDVKFGFLRDAITDYARSCKLTLKEPLVWFKERNDNESGSTPTTSATACSPSSSTGTGTGTGVSKIASNIDQKSIASDRNEENSLDGSKTGTWKSTKTRNKKPSRK
| 99 |
A0A1U8K226
|
5.1.3.3
|
ACT_SITE 185; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 317; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
|
MANIFSFCVFIVLSSLCFSKAQHVKVYELKRGYFSAKFTNYGATMLSVILPDKTGKLDDVVLGYDLVNDYKNDTTYFGAIVGRVANRIGGAKFILNGVTYKTDANDGKNTLHGGSKGFSDVIWTVKSYKKHSHVTFSYESFDGEEGFPGNLSVSVTYMLLHKNKLAVKMMAKPLNKPTPVNLALHTYWNLGGHNSGDIMSHTLKLFGSKITPVDSELIPTGEIVPVRKTPYDFRRPREIGSKFDQLPHGYDINYVLHKSRRSRHLRKVAVVVESKCGRKMELWTNMPGVQFYTSNMLKNEKGKNGTVYGKHAGFCLETQGFPDAVNHPNFPSQIVKPRGIYKHFMVYRFTAH
| 211 |
A0A1U7Z9L9
|
2.7.1.11
|
ACT_SITE 281; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186"
|
METISSSSSISAPKFRCFDPSNSTPPPNTRNHFFNSSSSSSSSSSSSSISSNSQIKSSRSSSELPTMSQPKIVTGEFGYVLEDVPHLTDYIPDLPTYPNPLQDNPAYSVVKQYFVDMDDTVPQKIVVHKTSPRGIHFRRAGPRQKVYFESDEVHACIVTCGGLCPGLNTVIREIVCGLNYMYGVNRILGIEGGYKGFYARNTISLTPKVVNDIHKRGGTILGTSRGGHDTSKIVDSIQDRGINQVYIIGGDGTQKGASVIYEEVKRRGLKVAVAGIPKTIDNDIPVIDRSFGFDTAVEEAQRAINAAHVEAESVENGIGLVKLMGRYSGFIAMYATLASRDVDCCLIPESPFYLEGPGGLFEYLEKRLKENGHMVIVIAEGAGLELLSQSMRNMDQKDASGNKLLPDVGLWISQRIKDHFSSRNKMSINLKYIDPTYMIRAIPSNASDNVYCTLLAQSAVHGAMAGYTGFTVGLVNGRHTYIPFNRVTERQNKVVITDRMWARLLSSTTQPSFVRPKELISKKQEPEPPTQLLDGENSHNDSDTQKK
| 84 |
A0A067H583
|
3.1.1.11
|
ACT_SITE 401; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MASKLFFVITIPILIALLPVFARPSHATDVAPTTPVSAGSVCKSTPDPSFCKSVLPNQTANVYTYGRFSIRKALWQSRKFLNLVDKYLTRRATLSTTAIRALEDCRLLAGFNMDFLLSSFETVNSTSKTLPTMQADDVQTFLSAILTNQQTCFDGLQDTASAWSVKNGLSLPLSNDTKLYSVSLALFTKAWVPKKKKATAWQPTRKQRLFRNGRLPFKMSEKTRVVYETVSRRKLLQAAPDDEVLVSDIVTVSQDGSGNFTTITDAINVAPNNTDVTNGYFLIYITAGVYEEYISISKNKKNLMIIGDGINQTVITGNRSVVDGWTTFNSATFAVVAPKFVAVNITIRNTAGAIKHQAVALRNGADLSTFYSCSFEAYQDTLYTHSLRQFYRECDIYGTVDFIFGNAAVVLQNCNIYPRLPMSGQFNAITAQGRTDPNQNTGTSIHNCTIRASSDLASGSQTVQTYLGRPWKEYSRTVYMQSFMDSSINPAGWQIWSGDFALSTLYYAEYNNTGPGSNTANRVTWPGYHVTINATDAANFTVSNFLLGDDWIPQTGVSYTGALI
| 125 |
A0A1S3YY77
|
3.1.3.3
|
ACT_SITE 88; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 90; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"
|
MEGLMSFQAQSVRAVSREQSSVPLPTFSSKITRVSVQPIGMVRNSKLFNSFVASVQPVEASAVTPFDNTLPSKEVLDVWQNASAVCFDVDSTVCIDEGIDEFAEFCGAGKAVAEWTARAMNGSVPFEDALAARLSLINPSLSQLQDFLKRPPRLSPGIDLLVKKLKDKKKDVYLVSGGFRQMINPVASILGIPLENIFANQMLFGSNGESAGFDKNEPTSRSGGKPTAVQQIKKAHGYKSVVMIGDGATDLEARMPGGADLFICYGGVQLRESVAAKADWLVFNFKDLINSLENWELTAPFRGCKIQVPTKFVVGDLDATYNVPGTKEYIHNGGFKKEVPNWQEGVVMEEVAHFINQEKPDEINAHIYDFIQRF
| 147 |
P25455
|
3.1.4.11
|
ACT_SITE 333; /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"; ACT_SITE 378; /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
|
MMSAGGTYISTASVEVPQALQDGEKFIRWDDDSGTGTPVTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEEGGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGGQKKELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKEKRLEMEKKLESLRKKHDKEKIKIAGQKSSPLEGKKPKFAITNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESAAADAGEDLAGGSSSLDGRTQESRLRSACREYTSQYRELQEKYHEAIYSAAEKVLKTSQTGQTKQLKASLDKVTGEVMHQLQEARRNEVKNLATVHRDRDELIRMKREVASSVVERGVAERVRLKQTFDRRTDELQKQHDSVRNALAEHRSKARQILDKEAESRSCVSSNGFLVLFHGPHHHGCTGSGSSALSGNNLTLNLDAGAAGSHSAISPAKSHNSIAAAAEMKT
| 153 |
B5YG54
|
3.1.1.29
|
ACT_SITE 19; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083"
|
MIVIVGLGNPGRKYAKTRHNVGFMVVDELARKYGLVFKEKNDYYITEWRLENKDITIIKPTTYMNLSGTAVKKVVNEKILKNLPESLIVIHDDVDMPLGKIKIKKNGSSGGHKGVQSIIDSLGTKDFIRIKIGIGKNPYQDVSEYVLSPFTSEQRAKIQEKISEAVESIVVIINEGVNKAMNIYNRL
| 127 |
P9WKI7
|
1.1.1.205
|
ACT_SITE 341; /note="Thioimidate intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000305|PubMed:26440283"; ACT_SITE 443; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000305|PubMed:26440283"
|
MSRGMSGLEDSSDLVVSPYVRMGGLTTDPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVDDDGALVGIITNRDMRFEVDQSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKLPVVDGRGRLTGLITVKDFVKTEQHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKSEVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTGGLRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYAR
| 3 |
Q8EGU7
|
2.4.1.18
|
ACT_SITE 415; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00685"; ACT_SITE 468; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00685"
|
MTQAQTYFYDGSDVALLNGQYTDVFSLLGMHSINEGKALVVRCFLRNAQKVDVISLKDGRKVASLERVNEAGLFAGTLGRRIKPFLYALRVTYPLCELDIIDPYQFGSLLNREDLYLFGEGSSEQAYRFLGANWRQVDNVEGVHFCVWAPNAKRVSVVGDFNHWDDTRHVMRQHVANGLWEIFLPGVVEGSHYKFDLVYQNGERHAKSDPMATQMECAPHNASIVPKKQQHQWADTQWMDKRAATAWHRAPMSIYEVQLGSWRRKGEFGEQYFDYQDLIEQLIPYVKEQGFTHIELMPVSEYPFDGSWGYQPVGLYAPTYRFGDANGFKAFIDACHQAEIGVLLDWVAAHFPKDPHGLVRFDGTCLYEHEDPRKGTHPDWDTLIYNYGRGEVRSFLLSNACYWLREFHLDGLRLDAVSSMLYLDYSREPGQWLPNAYGGRENLEAIDFLQMLNQRLYQAIPGICMIAEESTAFAGVTKPTDSSGLGFGFKWNMGWMNDSLSYLGRDPIYRQYHHNQLTFSLMYAYSEQFMLSISHDEVVHGKGSLLHKIPGDDWQKFATLRAYYGFMWGHPGKKLLFMGSEFAQRDEWDHDHSLDWHLLAFEPHQGVQRWLRDLNQLYRQFPALSVLDYEPQGFRWLDCDNGRDSIFSFVRYGEGNDVPLVFVVNMTPTVHQGFRIGLPQGGDFCEYLNSDSYLYGGSNQGNGGKIIAQALPWQGMASSALITVPPLGCLILGPATENILRESAL
| 73 |
W5MC70
|
3.4.19.9
|
ACT_SITE 138; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 248; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 248; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1"
|
GYCNLYFMEMNFLSHAFLLVVFLGCASSAVFKTAKINDRPIIGVLAQEIKSSENPEISYIAASYVKFLESAGARVVPVRINQSQEDYEKLFNSINGFLLPGGGVNLISSGYAKAASVFYQLAIKANSEGDYFPIWGTCLGFEELTYLTSGKILLVRTNTTSVALPLIFTKGARESRLFKNFPTELLEALATESITENSHIWSLSVEKYNSDEKLRKFYNILTTNKDEKLEFVSTMEAYDVPIYGTQWHPEKNAFEWTRPYIPHSPNAVKATFYMADFFVNEARKNFHHFPSEEEESKALIYNYIPVYKGNHSAFEQIYIF
| 176 |
Q9K056
|
3.4.21.89
|
ACT_SITE 123; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 178; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
|
MNTMLMSGAAAALLAGIILYFKSDKKRQENGEWSSGLEYAYILTAVGVFAALSLFMSFTAVFLIFVVLCGTAWGVYKYRLKTHPEISESSHFGDYFGSFFPTVLVLFLIRSFIAEPFQIPSSSMRPGLIKGDFILVGKFSYGLRVPVLNNIFIPTGKIERGDVVVFNYPLQPEMTYIKRIVGIPGDVVEYRDKILTVNGKPTSDIPDGTYRYPDDTDPSEIHNTDMFRSGLDGKSFNILKKEGQPAVSLPVLGKYTSDIMSENGYSIEQSGLEHCQYADDGSGFVCKVPEGRYFAMGDNRDNSADSRYWGFVDDKLVVGKAMFILMNFGDFGRSGTAIR
| 178 |
A0A9R0I7I4
|
1.11.1.7
|
ACT_SITE 157; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MSCQTPVILLKATIWVILILMSIVGESHGYRLHKTRSRLGHRGKFNGDVYALEGGHKRSRVLYVSPESDRTPFTPFTPFTSFTPFTPFSPMRSPSLPKTPSTPPTKPTRPPGLQVGFYKGQCPSTNVDVEATITAKVQEHFRKDATLLPALLRMQFHDCFVHGCDASILIDGPSSEKAAGPNLSVRGYELIDALKGVAEAECPGVVSCADIIAIATKQLIKLGGGPEYSVQLGRRDGLISKAQDVSLPSPFASVTQSIVAFGAKKFTPEEMVVLFGGHTVGKSHCTFFQDRLHVGASLFDPNMDPSLRRQLSLTCPKDTTTNNLAFLDQNLQSSNRFDNSFFDQILKGRGVLPIDQALARDPQTSGFVLQFAQNPALFNAKFVSAMVKMQALDVLLGNQGQIRKVCSKVN
| 14 |
O06735
|
2.7.1.25
|
ACT_SITE 108; /note="Phosphoserine intermediate"; /evidence="ECO:0000250"
|
MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLANAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMILTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTGIDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII
| 90 |
Q00534
|
2.7.11.22
|
ACT_SITE 145; /note="Proton acceptor"
|
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
| 102 |
A0A1U7ZY04
|
2.3.2.26
|
ACT_SITE 1566; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
|
MESRGRKRAELVDQLPADKRACSSSDFKPGSSSSSVQTQMASTNSASEAPDCEMETSSSASVSGRSEGEAEKDSAYGSCDSDGLDDPEQRHRSFREYHPRRSSSDQAKFKRILSSLADDAGPSSQVVALTELCDVLSFCTDDSLSSFTADSFAPILVNLAKNESNPDIMLLAVRAITYLCDVLPRSSGFLVRHDAVPALCARLMAIEYMDLAEQCLQALEKISRDHPLACSQAGAIMAVLNYIDFFSTSVQRVALSTVANICKKLPSDCSSSFMEAVPILCNLLRYEDRKLVESVAICLIRIVERVGHSSDMLDELCKHGVIHQVSHLVALNSRTTLSQPIYIGLIGLLARLASGSVLAVRTLIELNISSTLKQILATYELSHGMPHPHIGDMHSSQVHEVIKLLNVLLPPLPRNNEDIPLVSDKERILVDQPELLQQFRIDILPVLIQVVNSGANSYVCYGSLSVINKLVYFSRSDMLLDLLKNTNISSFLAGVFARKDHHILISALKIAKTVLEKLPDACFSSFVKEGVVYSIDALLMPERSPEIMFPTSTDIELSSGSNQKLAARDDPRCLCYALDSDQFPSSSEKGNCKLERNSVYTLAKKIKATYFATESHDSKIGMTETLQKLRTICTLLIDKVNIPMNDFTNDQHEECLYGILHQIMIELNGGEPMSTFEFIQSGIVKSLVNYLSCGQHMKEEVDQNVISIKYHFVLKRFEMFSMLSLMSVGGFWKDMPLANLTQKLLSAFSSLEDFPVILNHVSKSRNTYASIPSGHCTMHPCFKVRFVKEEGEACLCNYPGDILTVEPFTSFDAIEGFLWPKISGTTDEHHTSVCQPLVQCKSVLLPLPSDTRSPQGKDLNFVGEINSISSGVPEVQENQGNMSPPIKRAVDMIEGNPTTSHLVHTEPGSRIQDLQYSPEMDSDLKLVDSSNASASTSTSSGKECMEGRKCPTSCGNSDDPTKLVFHLEGRKLDRALTLYQEILNQHVKAENDMIVGPKFWNQVYKITYRKATDLEKCDSQDSCHGSSISSALNKLGTCWKDVPFLSGMLVSKLPCDLEKSNPTYDMLVLLKSLEGLNRSAFHLMSHERRCAFAEGRSNNFDDLRVNVPSLPQSEFVSCKLTEKLEQQMRDPLAVSVGGMPSWCAQLMAACPFLFGFESKCRYFQLKAFGSSRVQPHPWPQSATSNSNTSNDRQQHAVLLPRKKFQVRRSHILDSAAQMMDLYANHKAILEVEYSEEVGTGLGPTMEFYTLVSHEFQKAGLGMWREDHSTPTAGKGLDDNSSGFVAAHLGLFPRPWSPSLSADKTLVSEVIKKFVLLGKIVAKALQDGRVLDLPFSKAFYKLILEKELCIYDIQSFEPEFGRTLLEFQALVDRKKNLNSISEKGTNFISDSCFRDTRIEDLCLEFTLPGYPDYVLGSEPGNKIVNMDNLEEYVSLTVDATVNSGIIRQVEAFKSGFNQVFPIKSLQIFSEEELERLLCGERDAWASNEIVDHVKFDHGYTSSSPPVINLLEIIQEFEHDQRRAFLQFVTGAPRLPPGGLAALNPKLTIVRKHCSEWVDGDLPSVMTCANYLKLPPYSSKERMRERILYAITEGQGSFHLS
| 65 |
Q00495
|
2.7.10.1
|
ACT_SITE 776; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028"
|
MELGPPLVLLLATVWHGQGAPVIEPSGPELVVEPGETVTLRCVSNGSVEWDGPISPYWTLDPESPGSTLTTRNATFKNTGTYRCTELEDPMAGSTTIHLYVKDPAHSWNLLAQEVTVVEGQEAVLPCLITDPALKDSVSLMREGGRQVLRKTVYFFSAWRGFIIRKAKVLDSNTYVCKTMVNGRESTSTGIWLKVNRVHPEPPQIKLEPSKLVRIRGEAAQIVCSATNAEVGFNVILKRGDTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDAGIYSCVASNDVGTRTATMNFQVVESAYLNLTSEQSLLQEVSVGDSLILTVHADAYPSIQHYNWTYLGPFFEDQRKLEFITQRAIYRYTFKLFLNRVKASEAGQYFLMAQNKAGWNNLTFELTLRYPPEVSVTWMPVNGSDVLFCDVSGYPQPSVTWMECRGHTDRCDEAQALQVWNDTHPEVLSQKPFDKVIIQSQLPIGTLKHNMTYFCKTHNSVGNSSQYFRAVSLGQSKQLPDESLFTPVVVACMSVMSLLVLLLLLLLYKYKQKPKYQVRWKIIERYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEPSRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESILYCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQQICFLLQEQARLERRDQDYANLPSSGGSSGSDSGGGSSGGSSSEPEEESSSEHLACCEPGDIAQPLLQPNNYQFAC
| 97 |
B3S8X9
|
3.2.1.52
|
ACT_SITE 267; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
|
MASIQIIILITLLCQRWCDAGAAVNPNQDAIKAVGNLTKLFVQIDDVSANLTLNSDESYSLSIHAHPQPVAFLHAKQTWGALRGLESFSQLIDATYDGFFIQETKIVDYPRFKYRGVMLDSARHYLTLDVILQNLDAMSYNKFNVFHWHIVDDQSFPFVSLTYPQLSQHGSYTPRHVYTPDDVQMVIEYARDRGIRVIVEFDTPGHSSSWRSIPNFLTPCYSKNGVPNGQFGPINPILNSTYTILEDFFREIKKRFPDQYVHLGGDEVNFSCWQSNPDIQNFMTQHGFGDHYELLEQYYEHNLVTIMEKIGLRYIIWQDVVDNNVKVDPNTVVQVWKTSPSYKAELAKVTKMNLQTILSSCWYLNYIGYGRDWERFYRCDPQDFKGTQQQKNLVIGGEACIWGEYVDSTNLMERFWPRASAVSERLWSSAKVTNVDAALPRIDHHRCYQLIRRGLRAQPINGYSFCQAEYNVVMNHLDRDEL
| 170 |
H3GWW5
|
2.3.2.26
|
ACT_SITE 643; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
|
MDNERSTEASMLYQGVGMLLLCIIFFVVWLMACRRNRHLLDMEVPLLSGESVDHRIDAATREAEAGYSVCASCAFENFKRFEYCVLCGDKLPSLSFATADDESDDEQLKPEDTCSSRGGAINMAMSATHLLSPRPRKMSSLSRQQRRARSRREWTRKLDVEGNLFWYRSGGGGHVPANSDVDTLLPGYTLSFKLPEEVEQQELAEEQEQERTKEQEEQETMTETEPVPSLAVEQPQSEKENADDKPMLPTDVELELVEASVSDPADFATGKSTLADAGAERRKEVVSLATSDFPSKYAHFVVSTASLIVPAEVEFLKLSVHREYMLEESMDHMYCIQPKNLRSFMRINFLDESGVDAGGVHREWFMLVNELLASPTLRLFTCTNKADQSYFLNPQSRSEVGEDHLAYYFATGRLIGRALLEGGIWGFHLALPLLKVILGMPVTFADMEYLDPEAYRSLRWLMDNDGVDDLGLDFSLTEQVNETEKIVVDLIPNGRDIAVTDANKREYLDRRFRYVLFESVADQLHAFLKGLYEVIPREMLLIFDPEEFDYLLCGSPEVDVTDWETHTVLSPNLEGVSVTRWFWEIVRQMPNEYRRRLLLFATGSACVPLSGFRGLTSYDGRLCPFNLKGVPYRSTQYISSHACFNRLDLPLYHSKKELKSMLYATLDTDLTGFTTA
| 65 |
A7SXL4
|
3.5.1.2
|
ACT_SITE 99; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 203; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 205; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"
|
MGDKEAVTLRIGVLALQGGFFEHEASLMKALKYHQFEKLIEMEVVEVRDPENVADLDGLILPGGESTTMGLFLRSNGLDVRIREWIHSPERKAIAWGTCAGLILMSNSLEGQKGGGQDKLGGIDVTTSRNFFGRQLNSFEAPLNLKSLPVDQAGCHGVFIRAPAVMTINSPDVAVLATVDLPTSDKPVIVAVSQNNMMATAFHPELTEDPGWHAYFLQKVLNAKSSS
| 181 |
A0A0K9PZ97
|
3.1.1.11
|
ACT_SITE 244; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MSTTRAMAMALLLGLAMAADFHTAMCHTKGVRPGRYDLRSGYRVNSTEERLIEQKFMKWIWFVGSLRHSVFGNAVNKLFPSYTITVDKNPSLGDFTTIQSAIDSIPFINLVRVVVRINSGVYTEKVSISPLRGFVTIEGAGSHETVVRWGDMAETKDHNGRPIGTYKSATFIVNSNYFIAKNITFMNTSPVPRPGAQGKQAVALRISGDTAAFYNCRFLGGQDTLYDHQGRHYYRDCYVEGSVDFIFGNGLSLFENCHVHAVARKYGAVTAQHRMSMLDDTGFSFVKCKVTGSGALYLGRAWGTFSRVVFALTYMDNIVVDKGWYDWGDRNREMTVFYGQYKCKGPGARYSGRVKWSRELTDQEAKPFIGLSFIDGADWVSV
| 125 |
Q4WH91
|
3.5.1.2
|
ACT_SITE 81; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 191; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 193; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 238; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 400; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"
|
MPTVHLLDYVAGNVRSLVNAINKVGFDVEWIKSPADIQNADKLMVPGVGHFGHCLSQLSEGGFLEPIRQHIELGKPFMGICVGLQALFEGSEEDPDTPGLGLIPQRMQKFNADTKSVPHIGWNSAMNTTSERQTFYGLNPNSKYYYVHSFAALYKAGVLENDGWSVATATYGEEEFIGAIARENIFATQFHPEKSGQAGLRTLRAFLNGDKFQPLGTEGLEARKREDGLTRRIIACLDVRTNDAGDLVVTKGDQYDVREKAGVGAGGQVRNLGKPVDMAKRYYEQGADEVTFLNITSFRNCPLVDTPMLEVLRRTSETVFVPLTIGGGIKDTIDPDGTHISALDVATMYFKSGADKVSIGSDAVIAAEEYYRRGEKLTGKTAIETISKAYGNQAVVVSVDPKRVYVTSPDDTEHHTIKTKYPNASGQSYCWYQCTIKGGRESRDIDVRQLVKAVEAMGAGEILLNCIDKDGSNSGFDLELINDVKAASKIPVIASSGAGVPKHFEDVFRYTTTDAALGAGMFHRGEFTVGQVKEHLRNEGFLVRNFESDE
| 181 |
Q74CR9
|
1.1.1.100
|
ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1"
|
MSLAGKIAVVTGASRGIGREIALRLAREGADVAVTATTLDSARKTADEIEQIGRRALALAVDVADAAAVEALFASVVEAFGKVDILVNNAGITRDGLLLRMKDADWDAVLDVNLKGAFNCTREAAKLMTKARSGRIVNIGSVVGEMGNAGQVNYCASKAGMIGMTKAVARELAKRGITVNAVTPGFIETDMTAVLSEKVRESLMQQIPLERFGSPEDIANAVHFLVSDMGSYITGHVLSVNGGMYM
| 2 |
Q81BS6
|
3.4.21.89
|
ACT_SITE 40; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 81; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
|
MKENTKKELFSWAKTIGFTLVLIAIIRGVLFTPSLVQGESMMPTLKNNERVLVNKIGYSISGLDRFDIIVFHGKEGYDLVKRVIGLPGDTVEYKNDVLYVNGKAMEEPYLKQFKEKAVGRVLTPDFTLEQITGKTKVPEGQVFVLGDNREVSKDGRMFGFISEDEIVGKGQAVFWPLEQVRAL
| 178 |
Q01603
|
1.11.1.7
|
ACT_SITE 185; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
|
MIRARDLLLLALLGFISSALGLKVSSGYHIVHNQPQSSFPNYHGFSYLQGSAPYVIGNSLPTSPAPQNPFSSPASPPVSAYGYSFPTAGRVSCAAPPAVCEKTAYRTLDGSCNHLEQPGLGVANSKYGRLLTPKYADGISAPTRSVTGDELPSARLVSLVAFGEQDVPDPEFTLHNMQWGQIMTHDMSMQAGGTQSKKHPTRCCTDDGRLIGLDTAHKTCFAIIVPPHDPAYSQVGTECLNFVRTLTDRDSNCQYQGGPAEQLTVVTSYLDLSLVYGNSIQQNSDIREFQGGRMIVEERNGAKWLPLSRNVTGDCDAVDASEVCYRSGDVRVNQNPGLAILQTILLREHNRIADALSALNPHYDDRTLFQEARKINIAQYQQISYYEWLPIFLGGENMLKNRLIYKAPSGSYINDFDPNIDPSVLNEHATAAFRYFHSQIEGRLDLLSELRQVLGSLTLSDWFNRPGIIEVGDNFDSLTRGHATQPEELTDINFDRQIKHFLFRRNMPFGSDLRSLDIQRNRDHGLASYNDMREFCGLRRAHSWEGYGDLISPPILEKLKSLYPSHEDVDLTVGASLEAHVAGALAGPTFLCILTEQFYRTRVGDRFFFENGDKLTGFTPDQLEELRKASMARLLCDNGNHISSMQPEAFRTVSHSNPIIPCSNIPQVDLTKWIDQKLYATVDPSHYGKK
| 14 |
K3Y9T8
|
3.2.1.14
|
ACT_SITE 92; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1"
|
MASSATSRILALGLALLCAAGLAAAQNVASVVTDSFFNGIKNQAPSSCEGKNFYTRSAFLNAVKSHPGFAHGGSQTQGKREIAAFFAHVTHETSNLCYISEINKSNIYCDRDPKYKQWPCVSGKKYYGRGPLQLSWNYNYGPAGKSIGFDGLRNPDKVAQDPVVAFKAALWYWMNNVHRVMPQGFGATTRAINGDLECNGKNTAQMNARVRYYKQYCKQFAVDPGNNLTC
| 158 |
T1F578
|
3.4.19.12
|
ACT_SITE 90; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 166; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"
|
MAASAGDWCLIESDPGVFTELICQFGVTGVQVEEIWSLDAESFSFSRQRPIYGLIFLFKWKPDMHLQGNVIRDDRLRDIFFAKQVINNACATQAILSILFNCSDAKIDLGETLNSFKTFTRGFDPTTKGLALSNSDIIRQTHNSFAKQQLFELELENMKKDDEAYHFIGYIPINGRLYELDGLQEGPIDHGVIPEESEWLNYAKLVIEQRIQKYEADEIHFSLMAIIPDQKKHYEALLENTQDLDEVEKYKHLLNAEINKRKQYQVENARRRHNFIPFIIEFFKILAEKGELAELMEKAKVKAKDRANKAKASKPVKDS
| 175 |
E9HBA3
|
1.11.1.24
|
ACT_SITE 85; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR637944-1"
|
MALHIIKSSILSKVPESIVGLNFTVFGRKEIHLASTFNMPIKSGDKLPSVDLYENTPATKVNIAELTAGKKVIIFGVPGAFTPGCSKTHLPGYVSDFEKFKSKGVDEIVCVSVNDPFVMAAWGKDQNADGKVRMLADTNGAFAKAADLEKDLSGPLGSVRCQRFSMLVEDGVVKALNVEPDGTGLTCSLSNSILSQL
| 12 |
A0A251ST13
|
3.2.1.21
|
ACT_SITE 396; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
|
MHLEASVVFITTIIYYVSSIIKGLEAISSVGLPPNWALATINRSSFPNDFTFGSASSSFQNEGGANEDGRAPSIWDIFARRHPDRIADHSNAVMATDSYHRYKDVKMLRQMSMDAYSFSISWSRVIPHIEPFVTLFHWDLPQALEEEYGGFLSSRVVNDFRDFAELCFRRFGDRVKYWITLNEPWSYSVGGYEKGYYAPGRCSHFAGNCSAGDSGIEPYIVAHNLLLSHASAVKLYHDIYKGPQKGKIGISLVTRWMVPFSDEKLHRDAALRAIDFEFGWFMNPLTFGEYPESMRINVVNRLPRFTTEESYTLRNSLDFLGLNYFTANYVQHVSEAVTDNMTRSSDVQAHLSIERNGVPIGAKGGTEGLRSYPQGLHDLLVYIKNNYNNPTIYITENGVNVKGYFAWSLLDNFQWERGYAVRFGLHFVDYGNELRRYPKFSSTWFTNFLRIRG
| 161 |
A0A2I4GW44
|
1.11.1.7
|
ACT_SITE 81; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MAGFTSFPSASVLIWISSLLLASYACASEAVYYSVPLVNGLSWSFYESSCPKLESIIRKKLAKVFKKDIGQAAGLLRLHFHDCFVQGCDASVLLDGSASGPSEKDAPPNLSLRSQAFEIIDNLRERVHKKCGCVVSCADIVALAARDSVYLSGGPEYDVPLGRRDGLNFATRETTLDNLPAPSSNTSVLLTELATKNLDATDVVALSGGHTIGIGHCTSFASRLYPTQDSTMDQTFAKNLKEICPTSDSNATTVLDIRSPNKFDNKYYVDLMNRQGLFTSDQDLYTDSRTREIVTSFALDEDLFFQQFVTSMIKMGQLTVLTGGEGEIRANCFVRNSDNVNLTSAVEEEDQEAHSEL
| 14 |
A0A2C9UEY5
|
3.1.1.11
|
ACT_SITE 391; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MASDAHHPLLDSSTNSNSSPMVLVFLLSLSAFAVSSVFLAPHLLKVSQHSDPSFLQHLCDQAYDPQACLLTISEAVKDNGAVQQSNGINILKILLVKSLPQMTTAVEAAASGIKLQGKNQKDQGALADCLELMDLSIDRVNYILSAVANWSTHSDDAHTWLSGVLTNHATCLDAIADTTQQSMKVLLQDLISKTRTSLAVVASLSASKKDENLRTLNGGFPSWILARDRKLIESTSSNIQANVVVAKDGSGNFKTIQEAVESAPDKSKTRYVIYVKKGTYKENVDVGKKKKNVMIVGDGMDLTIITGSLNVVDGSTTFKSATLAVAGDGFILQNVCVQNTAGPEKHQAVALRVSADLSVINGCLIDAYQDTLYAHNQRQFYRNCFITGTIDFIFGNAAVVLQNCQIIARKPMPHQKNMVTAQGRIDPNQNTGTSIQRCKILASPDLESVQSSIRTYLGRPWKEYSRTVVLQSYIRGHIHPAGWAEWDGDFALKTLYYGEFANNGPGADTSNRVKWPGYHVITDPNEARKFTVAELIQGGEWLKSTGVSYTEGLYE
| 125 |
Q8I1U8
|
3.4.19.12
|
ACT_SITE 332; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 813; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"
|
MADIKSIISLISTIVKDEPTKEEVIYLGECSITGHKDFFEDGIFIDLLSFESFSLKFLKCNYNRLSKLSSEGKNHRFYLNIKKKKNLLENIEKKVITNLNINAEGGFNENKVYEYEWEYSVYDIETGLYIKLEDLDESVQKICKGIINHKNEVKKDNINKWVNDIKESKYAKDLVQLEGIKIKNENIHCAVCKSTKNIWLNLSDGYIGCGRKIFNYGGGCLNNEEGAALKHFYESGKKYPLVVKIGTITKDGEADVFSYADDENDSVIDPYIGVHLKNLGINIMNLEKTEITTLEKEIEENQNINFSSILDNNIQTICQQGKIGFVNLGNTCYMNSALQVLLSIKDISYRYLNNISDFLLSLDYKKKTHDDLFLQYSKLCYMIFEEDYITKKKQYVKKFKTQCKDRNVEINYDSDIDDENSVSINPSMFRNCINQKSNSFCNNNQQDIYEYLSYLINELIDNENNIFDRILKVNNNKRKLNEINNETNEKLNPNELLNSTSPSNNDSNVTKERSLFNYFTFEIEQRIESESNNQSISSFQNNILSLDIPLDSSLLNGDEEKLKNVNISLLDCLNNYIKKDNIDEYYCQKEKKKIHAQKYMKFKTFPPYLFIHLKRFYADENWSAKKINIEVKTDEQLNLEFMRVQPNSTDVLNGQKEQETSPGDSMLQKESKLLEDHKDVLDSLLDFGFEKDKAIEAIKKVKIKNVNNCISYIYGEDTVELDDDVNCEKEEVNSNNLDSIINLGVKKEVAMAALILNKNNLQKAIDYIFSNLDDLTDSKCNLIINSNKCNDGLANYELVASIVHIGNNANSGHYICYIKDESKWYICNDNKIGLCEGNLGKDSAYIHLYKRLS
| 175 |
G3SHL1
|
2.7.11.25
|
ACT_SITE 253; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000556-1"
|
MVQLVGKGGANLGRRAHRAGADWAPGAEGGAAGGGAGRSWGLARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPPPPRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAGAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRTPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSAAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELNILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSSSSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQMKERTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPKQIKLPSQAYIDLPLGKDAQRENPAEAESWEEATSANAATVSIEMTPTNSLSRSPQRKKTESALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTRLPSTGGEASSPPSLPLSSALGILSMPSLSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCPTAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPTPTGATIISATGASALPLCPSPAPHGHLPREVSPKKYSTVHIVPQRHPASLRSRSGLPQAYPQTAVSQLAQTACVVGLPGPHPTQFVAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRSKTSRPSIYELEKEFLS
| 105 |
O13310
|
2.7.11.1
|
ACT_SITE 216; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
|
MDKNDYLHFERNPSLFPKSTLDKVQKTKKYIEHYYKVAVDHAVERNQRRINLEQRLATERGSEERKNRQLRASGEKESQFLRFRRTRLSLEDFSTIKVIGKGAFGEVRLVQKLDTGKIYAMKSLLKTEMFKRDQLAHVKAERDLLVESDSPWVVSLYYAFQDSLYLYLIMEFLPGGDLMTMLINYDTFSEDVTRFYMAECVLAIADVHRMGYIHRDIKPDNILIDRDGHIKLSDFGLSTGFYKQDQSASYMKPRTGNTVKRGQMVDAIWLTMSSKDKMATWKKNRRVMAYSTVGTPDYIAPEIFLQQGYGQDCDWWSLGAIMFECLIGWPPFCSENSHETYRKIINWRETLTFPNDIHLSIEARDLMDRLMTDSEHRLGRGGAIEIMQHPFFTGIDWDHIRETAAPFIPNLKSITDTHYFPVDELEQVPEQPVTQQPASVDPQTLEQTNLAFLGYTYKKFNYLTMKGAL
| 99 |
F0ZP67
|
1.11.1.24
|
ACT_SITE 46; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
|
MGLLKAGSIAPDFICKNQDGVDVKLKDFSDKPLVMFFFPSNIGMICTRENIEFKENYQKFIDANCHVVGISGDKIKKQKKFHCKNDLPFPLLIDRKRKIEKAFGAHFSRATFVIHNGEIVLSHLTHWFTSKSHIEESLKVVEFLNGNK
| 12 |
A0A251TP05
|
3.1.1.11
|
ACT_SITE 423; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MDTIKSFKGYGKVDPAEEQAFRRKTRKRIIILTVSVVLLLAVIIGAVAGTLIHKRNKNNDDSTVGSNDSAQSLKAVCSQTLYPESCYNSISEINKSNSTDPEELLKLSLQVVLKSLSDVATLPDKLSSKTTNETVKKALGVCGTVLNDAVEYLQDCLSEMDVKPNEKLLTLPKVEDLKTWLSTAITNQETCIDALDEMSPNSTFVDDTKSQMKNSTEYASNSLAIVSKIAGILRKLNINFHRKMLTVTVTEPGFPEWVSPGVRRLLQEVRPTPNVTVAADGSGDVRTIKEAMAMVTKKSKSVFIIYIKEGVYKENVVLDKSFWNVMIYGDGKAKSIVSGNLNFIDGTPTFSTATFAVAGRGFVAMDMGFINTAGPEKHQAVAFRSGSDFSVFYRCSFDAYQDTLYPHSNRQFYRECDVTGTIDFIFGNAAVVFQNCKIMPRQPMANQFVTITAQGKKDPNQNTGISIQKCDISAFDQLTAPTYLGRPWKEFSTTVIMQSNIGAFLKPQGWISWVSGVDPPESIFYGEYMNTGDGAIVGQRVKWAGYRPSLTSSDANRFTVANFIEGAMWLPQTAVKFESTL
| 125 |
A0A9J7LEX6
|
3.1.3.1
|
ACT_SITE 127; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
|
MGLYRFLLVATTILPTTMEQALSGRQTTFSEAQGRTPHQELDPAFWNDMAHRDLDRAIQLQKLNLNMAKNVVLFVGDGMGLTTVTTGRILKGQLQGQPGEETVLAMDSLPHVGLVKTYSLDYQVPDSAGTATAFLSGVKAARGTIGVNGRVQHGVCATQKGNEVNSILVLANQAGKSTGVVSTSSLTDATVASTYAHSASRYWDTDANLPWEAIYKGCKDIAAQLVDNAPDIEVLLAGGRQNFLPRSVADMEYPNKFGTRRDGRNLVEEWITTKPGTARFVWNLDEFNAIDSNRTDYLLGLFEPHHMKFSVDRDLDGAGKPTLSDMTQKAIQILQKNSNGFFLLVEGGRIDHGHHANQAVRALHDTVAFDDAIQVAKDMLDMQDSLVIVTADHSHTFNFGGYPSRGHPIFRKTDYNFGFELLDRKPMTSLLYGNGPGYSLSGTRQDITNVNTGRKDYKQQSAVPLAHETHGGEDVPIFAGGPMAHLFHGVREQNYIAHVMKYAACLGEYRENCHSLRKPRATRGGVAVRSWDFQTTIAVLILVVAIM
| 141 |
A0A067FS47
|
1.11.1.7
|
ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MRTKGSFVLFFFFFIFPLALAQLRPGFYGTSCPRAESIVSDLVQKRFSADNSVTAALLRMHFHDCFVTGCDASILIDSTNQTQSEKESGANQTVREFELIDEIKKALEAECPSTVSCADIITLATRDAVTLAGGPRYTVLTGRRDGLRSNVDDVDLPGPQISVPDAQQVFQAKGLTSDEMVSLLGAHTVGFAHCSFFKDRLTNFQGTGLPDPTMNVTLIPKLRRICDAASTDNFGPKTFLDQSTNFVFDNKFHSEILSRRGILQIDQELGLDRSTAPMVSKFAFNSDEFLRSFASAMVNMGNIQVLVGNAGEIRQNCRAFNPLKAPTPSNPGNTPKPIPKPKPKPRPRPGKGGRKQKPPGKERKNKIPRIF
| 14 |
B5ZY73
|
1.3.3.3
|
ACT_SITE 131; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333"
|
MERPELPIGLPEDIEEKKAAARSWFEGLRDTICASFEALEDELEGPLSDQEPGRFVAKDWSRENGAGGGGRMSMMEGRVFEKVGVHTSTVHGEFSPDFRAQIPGAKDDPRFWASGISLIAHPVNPNVPAVHMNTRMVVTSSRWFGGGADLTPVLSRRRTQEDEDSQLFHKAMEIACRNHAVADYDAYKAWCDDYFFLKHRNEARGIGGIFYDWLHSNEDAGGWDADFAFTRDVGRAFSMVYPKIVRSNFNKLWTEADRDEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVESILSSLPPVVRWP
| 27 |
Q6AXR4
|
3.2.1.52
|
ACT_SITE 333; /note="Proton donor"; /evidence="ECO:0000250"
|
MPGSPRRAPGLLLQALVAMVSLALVAPFGLQPALWPMPRSVQVFPRLLYISPENFQIDNSPNSTAGPSCSLLLEAFRRYYNYIFGFYKRHHGPAKFQDKPQLEKLLVFINLEPQCDAFPSMSSDESYSLLVQEPVALLKANEVWGALRGLETFSQLVYQDAYGTFTINESTIADSPRFPHRGILIDTSRHYLPVKTIFKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYTPNDIHMVLEYARLRGIRVIPEFDSPGHTQSWGKGQKNLLTPCFIQKIRTQKVGPVDPSLNTTYVFFDTFFKEISRVFPDQFIHLGGDEVEFECWASNPNIQNFMKKKGFGNNFRRLESFYIKKILDIITSLKKSSIVWQDVFDDQVELQPGTVVEVWKSENYLNELAQVTASGFPAILSAPWYLDLISYGQDWRNYYKAEPLNFEGSEKQKQLVIGGEACLWGEYVDATNLIPRLWPRASAVGERLWSPRIITNLENAYRRLAVHRCRMVSRGIAAQPLFTGYCNYENKMEK
| 170 |
Q54B33
|
2.7.11.1
|
ACT_SITE 771; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
|
MEEDKDSDTLQILNDIINNEPNLEIYVKSKNNNYISSRELPTQDSSTKTSNITTPNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTPTSLNSSWKSVVPKRKIDTSSGAILNNNNNVGSPNNQSTSQTNHQQPPPQQLQQQQSLSSTSTPSISPPMLSPSRRNVTSPNLTRSDPTVPITNSRPTSPLTPPLSPQFQLNNLNFDDNNDHSTTTTNNNNNNNNNNSNNNNNNNRPKLMRENSINKRSSLQTLPVSSSSSSSAEDEILIKVWLPMEYTGQLYKVRKFSGGSSTLKVSSMLNSQLSPMYQSPKNKLFLNNEEKPIPSHLTLKDLSLSKYDILYLRREPEYELIIPSSPQCGSLVMDKDIKIDDMLIKIEHWLKDILDHAPHSTSQQQQQQLQQQPILHVDKHEYFTSLEDQQLMSGHITNSSQYTLLKKLSVPTSNSRQTGKMSRGYYLRLYDQKPISNYGIKIKDTLIFKKKILNRGLSIDDAEGGIEITVLYSPLSMLPTTSDLDFEKELKENQQQLNNNNNNNNNNNNNNNNNNNNNNNNITTTTTTTTSSLINQTNEILLPNLIKIDNTSLLQDIKNEKKKRKSKRTPSSVGLPFNIIHKTHVDFEYKWSGTSVEDTFEFKEKLGQGGYGAVFKVLHRETNFPLAIKVLSITPTRIKDIEKEIDLLKKCRCPNVLSYYGSISSKLTELWILMDHCAVGSINDMMKICCDTLDEEQIAVVTLNVLNGLGYLHSKGIVHLDVKAANILLTEDKQIKIADFGVSQQLQTEYGQANVYIGSPLYMAPEVILKAPYNSKADIWSLGITLIELAEGRPPNRGLRSMNQLVEIPNMPPPKLSNPKDWSPCFNNFLATCLVKDPVQRPSVIDLLSHDFIKNAKTTEVLSNLVKQTLSSRQSI
| 99 |
A0A1U8Q239
|
3.1.1.11
|
ACT_SITE 405; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MGKLIALGISLLLVVGTAINTAVGHDTDGFSAGDIAKKAMSSTAMKNVKAICALTDFEDACIKTLTPVANNKSATPEDYLKAAFEATNGEVEAALEKSGVIGKDAQGSIDKMAVEDCKELLQFAIDDLQSAISMAGDPEKNKAADVTAEFKNWLSAVVSYQESCIDGFEHPELKNSMQNGLLNATQLTSNALTIIGQMSSILKALNINFDFNIKSRRRLLDAQGYPTWFAPTDRKLLALQDNGRVAPNAVVAKDGSGHYKTIAEALAAYPKKKGSQKNDSSTSRYVIYVKAGTYDEYITITKDQTNILMYGDGPTSTIITGHKSNREGISTFQTASFSVIGDGFICRSMGFHNTAGPEGHQAVALRVQSDRAAFFNCRMDGYQDTLYVQAHRQFYKNCAISGTIDFIFGDSSTVIQNSLIIVRRPLDNQQNTVTAQGKKFKDESTGLVLQNCKIVPEQRLVAERLKIPSYLGRPWKEYAVTVIMESTIGDVIRPEGWMPWAGDFALDTLFYAEYNNRGPGANTDHRVKWKGFKVITKKDEALRYTVGPFIQGDEWLKDTGSPFTLGLRY
| 125 |
O61122
|
2.7.11.1
|
ACT_SITE 132; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
|
MASKKGDPEELYVRQEKIGKGSFGEVFKGINKKTNETIAIKTIDLEDAEDEIEDIQQEINVLSQCESPFVTKYFGSFLKGSKLWIIMEYLAGGSVLDLMKPGPFDEGYIAIILRELLKGLEYLHSEGKIHRDIKAANVLLSASGDVKLADFGVSGQLTDQMTKRNTFVGTPFWMAPEVIKQTGYDSKADIWSMGITALEMAKGEPPRADLHPMRALFLIPKDPPPTLEGNFSKGFKEFCALCLNKDPNQRPTAKDLLKHKFIKAAKKTSSLTDLIERRQKWLQLNGNNADDENDDLDRDAKSNEEDFGWEFPTIKQKSPVAVQEQQQTPQKPTVVSTPIKEQQQQQQPTPVTTPQQPVTTTTTTPTTETKVRSLSNSSQTTPVKTTVAATTAPATTPASNAPTSTTPNGAAVTQQQAPRASALTSVIYPVLSKLLKNTSDENVINALAQLKMAFDNAEKAKPGITHSLIAQIIETLKR
| 99 |
A0A9R1UFD9
|
1.11.1.7
|
ACT_SITE 92; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MNTSSKDVLKEMLASVCRDLCEAKTEVFSRNKGTLFFLVLFASLITLALGQTRVGFYQTSCPRVEAIVQAAVDAANRANPGVPPGLVRMFFHDCFVNGCDASILISGTGSERTAGPNTLLRGYEIIDAAKTQLEIECPGVVSCADILDIAARDSVLLAGGIARWQVPTGRRDGLVSRAADTTNLPAFNDSVDVQIRKFAEKGLNTQDLVTLSGAHTLGTGACLVFSYRLYNFNNTNGPDPSIDPAFLTTLRNLCPNGGDSRRRVALDTGSENRFDTSYFANLRSGRGVLESDQLLWGNPTTRTIAQRFLGVSGLAGLTFNVEFARSMVRMGNIEVKTGTQGEILPLGRRDGLVSRAADTINLPAFNDPVDVQIRKFAEKGLNTQDLVTLSRAHTLGTGACLVFSYRLYNFNNTNGPDPSIDPAFLTTLRNLCPNGGDNRRRVALDTGSENRFDTSYFANLRSGRGVRESDQLLWGNPTTRTIAQRFLGVSGLVGLTFNVEFARSMVRMGNVEVKTGTQGEIRRVCSAFN
| 14 |
Q09488
|
2.7.11.30
|
ACT_SITE 397; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
|
MNITFIFILIFGFFNTQKCSKDYDHFDDEDLALSIPKNAIGVPKEFRQQVLKEMKLRNRPNDILKNRCYCNYDQSICGNNMTCVKQDGAACYHAVEEVYNKAEKRMETLHKWGCATLERGSGASHLTCNSWRAAHHSPKSIGCCYEGNYCNKNLIPPAYVHHHKEKALQEKTDNPEDYDSPLENMTRGGKMFIMVFATVMSVFAVIGCIYLCITRAEEKSKARARAKTVSLKTESTYMESKSMLEDSGSGSGQAALIQRTVRQDLTIIKTIGQGRYGEVRKALYRGSYVAVKTFYTTDEDSWKNERDVYQTNMINHENILQFVAADIWSEEDSMTKMLLITDYHELGSLSDYLCREETLTTDEALRLIHSCICGIEHLHAAVHGTGSFRKPEIAHRDIKSKNIIVKRPNVCCIADLGLALRYQNDKILPEKFNVQVGTKRYMAPELISNKLNPKDFSQFKMADIYSMALVMWEVAIRVEVNTCEEVLTVDETSPDHSASSGIGESVSSSGNISRMHLQKTNVEGHSTSLKAKQHVPPFDGIVHNDPNFDEMNDVICVRRIRPPPDLAWKNVPALNELSKLMEDSWHSIPHFRHSALKLKKEMAELIKNPDRQNQSQRKVEFQQQDSGLVESATNQS
| 106 |
B8C0V6
|
2.3.2.26
|
ACT_SITE 324; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
|
LRLNLRRKYVFEDSFRAFIHRNAEELRGRLHITFQNEEGVDAGGLSREFFAILAKEMFNPNYALFMSTEDGCTFQPNPNSSINLDDLNYFRFVGRIVGKAVTDGYLLDAHFTRSLYKHMLGIKPTHHDMQAIDPDYYKNLQLILEHNLEDIGLDLTFSTEDHSFGRSRTLDLIPNGRNIPVTEETKARYVDLVCQHRMTTAIEKQIKAYLEGFHELVDPDLISIFTAKELELLISGMPDIDIHDLKKNTDYNGYRPADQQICWFWNIMFSLSRSEKAAFLQFVTGSSKVPLAGFSELQGMRGLQKFSINKASGSAGALMSAHTCFNALDLPVYKSEEEMKEKLLYAISEGGGGFLFA
| 65 |
P32660
|
7.6.2.1
|
ACT_SITE 667; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250|UniProtKB:Q9Y2Q0"
|
MSGTFHGDGHAPMSPFEDTFQFEDNSSNEDTHIAPTHFDDGATSNKYSRPQVSFNDETPKNKREDAEEFTFNDDTEYDNHSFQPTPKLNNGSGTFDDVELDNDSGEPHTNYDGMKRFRMGTKRNKKGNPIMGRSKTLKWARKNIPNPFEDFTKDDIDPGAINRAQELRTVYYNMPLPKDMIDEEGNPIMQYPRNKIRTTKYTPLTFLPKNILFQFHNFANVYFLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIEDSRRTVLDLEVNNTKTHILEGVENENVSTDNISLWRRFKKANSRLLFKFIQYCKEHLTEEGKKKRMQRKRHELRVQKTVGTSGPRSSLDSIDSYRVSADYGRPSLDYDNLEQGAGEANIVDRSLPPRTDCKFAKNYWKGVKVGDIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGETNLKVRQSLKCTNTIRTSKDIARTKFWIESEGPHSNLYTYQGNMKWRNLADGEIRNEPITINNVLLRGCTLRNTKWAMGVVMFTGGDTKIMLNSGITPTKKSRISRELNFSVVINFVLLFILCFVSGIANGVYYDKKGRSRFSYEFGTIAGSAATNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAAFIYGDVLLYNAKLDYPCTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGIDVETEGRREKAEIAKDRDTMIDELRALSGNSQFYPEEVTFVSKEFVRDLKGASGEVQQRCCEHFMLALALCHSVLVEANPDNPKKLDLKAQSPDEAALVATARDVGFSFVGKTKKGLIIEMQGIQKEFEILNILEFNSSRKRMSCIVKIPGLNPGDEPRALLICKGADSIIYSRLSRQSGSNSEAILEKTALHLEQYATEGLRTLCIAQRELSWSEYEKWNEKYDIAAASLANREDELEVVADSIERELILLGGTAIEDRLQDGVPDCIELLAEAGIKLWVLTGDKVETAINIGFSCNLLNNEMELLVIKTTGDDVKEFGSEPSEIVDALLSKYLKEYFNLTGSEEEIFEAKKDHEFPKGNYAIVIDGDALKLALYGEDIRRKFLLLCKNCRAVLCCRVSPSQKAAVVKLVKDSLDVMTLAIGDGSNDVAMIQSADVGIGIAGEEGRQAVMCSDYAIGQFRYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALALFWYGIYNDFDGSYLYEYTYMMFYNLAFTSLPVIFLGILDQDVNDTISLVVPQLYRVGILRKEWNQRKFLWYMLDGLYQSIICFFFPYLVYHKNMIVTSNGLGLDHRYFVGVYVTTIAVISCNTYVLLHQYRWDWFSGLFIALSCLVVFAWTGIWSSAIASREFFKAAARIYGAPSFWAVFFVAVLFCLLPRFTYDSFQKFFYPTDVEIVREMWQHGHFDHYPPGYDPTDPNRPKVTKAGQHGEKIIEGIALSDNLGGSNYSRDSVVTEEIPMTFMHGEDGSPSGYQKQETWMTSPKETQDLLQSPQFQQAQTFGRGPSTNVRSSLDRTREQMIATNQLDNRYSVERARTSLDLPGVTNAASLIGTQQNN
| 259 |
A0A6I8N2V4
|
2.7.10.1
|
ACT_SITE 778; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
|
MHLGGLTALVTAVVWHGGASLLLEPSSPDLVVESGAAVTLRCPGNGSVEWFTGLGWGEPAPGWVPGFEGGSRTLSTARATYRDTGTYRCVDSESPDGKEASGHLYVKDPEHPWSVAARTIMVTAGNDALFPCRITDPALAARVSLQRDSGKNVRRGTRLTFDPRKGVTIHKVQLLDLNSYQCTAIIGGEKKPSPTIELKVKEAITEPPLLWLEPRESVRIRGEPFSVTCEASNPNVDFDLTLQHQQEQVPGNLIADFALTRGYSKNISHRIARVAEEDGGTYSCNSTNVKGSSVASMVLRVVDRAYVNLSSEQSRRLEVDVGEKLELGVHVEAYPQLLHWNWTFDGPFRTADPKFPAVLTGETYRYDTTLALPRLKESESGRYTFHAENAGAGASFTFDVVLHYPARAELNWDQFNNSNSLLCVASGYPAPKIVWSQCPGRNRRCDQEQELLWKDDYPTVVSEVPFGKVTVQSILPIEKLEANVTYVCTAENRAGNHSDEYFPVSLVESFKPAEDPFFTPVLFTCVAIMVLLSLLLLLLLYKYKQKPKYQVRWKIIETCEGNNYIFIDPAQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGHHENIVNLLGACTHGGPVLVITEYCCHGDLLNFLRRKAESMVAPNIILESSSASSVEYKNIYLEKKYVQSDSGFSGQGPDHYVEMRPVSLDPFPDQDTDKEDRRSLDLNDLLHFSNQVARGMAFLASKNCIHRDVAARNVLVTSGRVAKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCIYTVQSDVWSYGILLWEIFSLGLSPYPGILVNSKFYRLVKEGYQMARPVYAPWGIYGIMRACWDLEPTRRPNFQQIRSLIQEQMEVGSKGQDYTNLPGGEADDSMSEPPPCGEESCEESCEQADGSQPLLKSNNYQFC
| 97 |
Q818U9
|
2.7.7.7
|
ACT_SITE 116; /evidence="ECO:0000255|HAMAP-Rule:MF_01113"
|
MSTMREMYPKNGRVILHVDMNCFFASVEIAHDPSLQGKPLAVAGNEKERKGIIITCSYEAREYGIRTTMPLWEAKRLCPQLVVRRPNFTLYREASFQMFQVLSRFTEKIQPVSIDEGYLDITDCYALGSPLEIAKMIQQALLTELQLPCSIGIAPNLFLAKTASDMKKPLGITVLRKRDIPEMIWPLSVEAMHGIGEKTAEKLNEIHIHTIEQLAKGDEHIIRAKIGKHGIDLQKRAKGTDDREVDPSQMGQHKSVGNSMTFSKDMDEEKELLDMLERLSKSVSKRLQKRTLVSYNIQIMIKYHDRRTVTRSKQLKNAIWEERDIFQAASRLWKQHWDGDSVRLLGVTATEIEWKTESVKQLDLFSFEEDAKKEPLLAVIDQINDKYGTPILQRGSQLLRKQEKSFQQKLENKFM
| 121 |
A0A9R0K247
|
2.1.1.37
|
ACT_SITE 427; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
|
MADTMAEENVSMKRSFAECPVPCPKKKRVVSKDDIDECRFTGNPVPVQQAKEQWPHRYLCKAKEANAASFKIEWNCEEILQASNHYTQALVDGIIIKLHDDVYIQGDEGKPNYIAKIVEFFEGIDKKQYLTAQWFYRADDSVIKDHANFIDKKQVFFSDVKDDNELGCIVEKVKIDINPSDVGADKPNEYLYCKMRYRLPYLTFENMVQDEQNEGTGSDTSSTISSDHSSNEAVDDDSSTAKKEFSLLDLYSGCGAMSTGLCLGATLSGIKLVNRWAVDLNEYACESIRNNHPETKVRNEMAGDFLALLMEWEKLCNEYVLSPAPPSEVTNSEEEEEEEDDSPLEPGEFEVENILDICFGDPNYMKKRGLYFKVSWKGYTSEYDTWEPIDGLSGSEERIKEFVSRGYNEKLLPLPGDADFICGGPPCQGISGFNRFRNTVNPLNDEKNQQLVVYMDIINFLKPKYVLMENVVDLLRFAGGFLGRYAVGRLIGMNYQTRMGIMAAGSYGLPQYRMRVFLWGAHTSQKLPQFPLPTHEVIARGGVPVEFSDIHVSHGKNSSVKLERALLLKDAISDLPSVTNGEDREEMDYEGDSQSEFQQYIRLPRAQMVSFNDTHVVSSFPTNNILYDHNPLRLNDDDFERVCRIPKEKGANFRNLPGVLVDAKNKVYLDPSMERVLISSGKPLVPDYAITFVRGTSSKPFGRLWWDETVATVVTRAEPHNQIVLHPQQDRVLTIRENARLQGFLDCYKLYGPVKERYIQVGNAVAVPVATALGYAFGMASQRLGDEQPLMTLPFKFPHCLALNQH
| 47 |
H3GG84
|
2.3.2.26
|
ACT_SITE 383; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
|
MEEFPRATSYIDFESVAALPFRAKVRWLLKELDKVAIPWGEGHLLLKIRREAVLSESMHLLMLVPASDLRQRLRIEFIDEPGLDAGGLLREWVLLLCEQLFDESYGLFQRTHADQSGYWINPNSREIHRDHLHCFQFVGRLLAKCLLEGQLMTVHLALPLLKHLLGVPISFSDLEFLDAELHRHALWLRDNEGAEALALDFTVQRQANNGTVITEELKQGGKDIPVTDANKEEYLTLLLRHKMFAGVHDQLEALLQGLYDVLPRTLLAVFDYQEMELLLCGVPSIDVADWESHTDVRYMRAEQGLNRPSSPERQVVQWFWDAVRAFSQEERARLLQFVTGTSRVPAEGFRALLSHDGRIRRFGLQMMPLGAPPTGLYPKAHTCFNRLDLPVYPSYQELEKYLTLVINMEIAGFTMQ
| 65 |
B4N1W9
|
3.1.1.5
|
ACT_SITE 1000; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 1120; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
|
MDVLELLRASANGCYNTIFSDAWSQYVSQQITSSLYLYIALGILTVLFVAWFIYFKRLARLRLRDEIARSLNAVTSASGGDLRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQLRRENMPLEMRTVEPPAEYLEETIEGSDRVPPDALYMLQSIRIFGHFEKPVFLKLCKHTQVLELMAGDYLFKITDADDSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAMEKSVVIRLPMQAFEEVFRENPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMRNKSITISGHLNSQSQSSQSMRQQTTATATGGTSATALGGQQLPAAVPSLPLQRQPPPPTIAPPLRHSREEHTLSGPNPNPNSGNNVQLPEVHGDAPNIDIYHQQQHGGSTSTGNLSTRRGSLVQPSIGGGGGGSTAQEGGCAAAGAPTIDMRLIQSSAVESLRKELGLPNEDAHIIEPFVEVRELEPNVTLITEGNADDVCIWFVMTGTLAVYQGVADATRSSTATTKSDKSDLLIHFVHPGEIVGGLAMLTGEASAYTIRSRNNSRVAYIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITNPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVMAVRDSELAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGSMQTRGSTGAPGAPVEANPVTHKYSTVALVPITDEVPLTPFTYELYHSLCAIGPVLRLTSEVVRKQLGQNIFEAANEYRLTSWLAQQEDRNIITLYQCDNSLSPWTHRCMRQADVILIVGLGDRSHLVGKFEREIDRLAMRTQKELVLLYPETTNAKPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLYSRVLLSEPNMHSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPIDMVGGVSIGALMGALWCSERNITTVTQKARQWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPGHLWRYCRASMSIAGVFPPFCDYRDGHLLLDGCYTNNVPADVMHNLGAAHIIAIDVGSQDDTDLTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYKTLAFGSFDEIRDVGYVFGKNYFESMAKAGRLGRFNQWFNKEPPKRGNHASLNEYTFIDLAQIVCKLPETYAVNTAEIFSEDEDCDGYISEPSTLNTDRRIQVPRAGNSLSLSEAEMDSDVEIDFRSDSKKDKATQSTPPAPGKDNEDKTDAVDRIPLLTLERPLTDQQQQHSDETDEQETPRAMKDGTNTMTTQTTSPTTDAGSEWAGSESELEKENKNVNTKN
| 131 |
K3YG96
|
2.3.2.26
|
ACT_SITE 783; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
|
MATPGAAASEPDHGAPPTAAVQLLLRNIDSRTTVIRARREDTVGSVLDRLGNGVPPRGGELRAVHAGRELPRGATVGELGLPWDATIHVSYRLLSTPHADAWRLASEITAAARVAATATGGQQQPHEAAPLEKLVRRFLDSAGAAQQRRSHSALGPVADHLDIFLRSGAPGVLVQLYHSNDEHRRAVAERAIRCFLCPDAPSGKGIVRAWTAPVLLEFCGSIATGARTGDSLYTALRSMLATVLSDPEWTPERWHGVSWRRVAEQSTRLAGEMAKGIIQEIATAYRSCWSRPAAATRNLVEFKAFWSVLRRQVLELDDDRIQPWRKLLSQILEYLLRSVKDCMARFEMSLPPAPPPGHRHTSSSSALPKWTASLHSVWAVLAELDDWPDLHHAMRATLAAHARAVTALVLSAGSEFIENIRWITRHRDLLEFDARRHLAMAMLPELVRGTDARPPYELLVDRARLLPDSFGYIVHATPQELGAAMSVAFKHEQATGPGVLREWFCLVCQALFNPRVVLFSACPHDRRRFFINPTSVVDPLHLEYFEFAGRMIALALRHKIHVGVYFDRTLFLQLAGRPITLEDIADTDPSLHASCKKILEMDPGLVDSNTLELTFVREDEVLGSRTVTELFPGGKDIAVTSENRCKYIDLLIQDRFVNCTRRQLAYFAAGFRTMFDKWKPWTEFFASLDNEDFDQMLGGSKGTIDVNQWRAHTDYRGYKEKDRQIKWFWKAVENMTVEQQGRLLFFWTSVKCLPSDGFWGLGCRLFIYRASSSRDHLPTSQTCFYHLHLPAYTSSSMMQSRLRVIVQEHVSSGFGAS
| 65 |
A1TKQ3
|
2.2.1.2
|
ACT_SITE 125; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492"
|
MNQLDALKQVTTVVADTGDFRQLGAYRPQDATTNPSLILKAVQKADYAPLLQESVERWRGRALDEIMDRLIVRFGCEILSLIPGRVSTEVDARLSFDTMATVTRGERIIDLYRAEGVDTARVLIKIAATWEGIEAARILEERGIHTNLTLLFSPVQAVACGAARVQLISPFVGRIYDWYKKQAGAQWDEAAMAGANDPGVQSVRQIYQYYKHFGIRTEVMGASFRNIGQITALAGCDLLTIAPELLAQLAASEAPLERALDPASAKDLELQPVQYDEPGFRYALNADAMATEKLAEGIRAFAADAAKLEQMVLAA
| 52 |
K4AL78
|
3.2.1.14
|
ACT_SITE 92; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1"
|
MRRLFALLALAGAALLAAAGGASGQQGVGAIITRQVFESMLSHRGDSGCQGAFYTYDAFIQAAGKFPAFGTIGDDQTRRRELAAFFGQTSHETTGNLHTVDGQLLRGWPFAWGYCRVEEQQRTDPPYYGRGPIQLTHKYNYELAGRALKLDLVSSNPVVAFETAIWFWMTPQAAKPSCHDVITRRWVGGRWQPLLRDPDDRVGFYRMYCEMLGVAEGGNLSCEIQKPYGPTG
| 158 |
A0A2K1ISV7
|
3.1.1.11
|
ACT_SITE 453; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MGKASRCLNGERANVDGKREMKDFQCKPSKCKVRTTQIIERVVRFFALLSLLAPSDCTQILRGYREGRNLSAQASQLRQLKQAPDPVNTYNIELVCSATRYPASCLSALLLDARSVNAPPRRLVEILTAISMEHSLAALLDGQTLATLVPTANNVNLTAVSAQCMELLDLAAYHMQNSEAAFPARLFQDILAWLSGALQQTNDCYYALTPFRSSTSSLAFVTEMTDRLNTTVELISNSLALTGSMVSYGSDATGWKSPPESRVDQLLELNETSNTDISPGWMGVADRAFLHAPSPQAALDLGELVVTVALDSISPSIQAAVNDAPSWCPTRYVIYIKAGVYNEIVRVPKDKINLMFVGDGSNATIITGNLHVQTPGITTWLSATVAVTGAGFIARGISFENTAGPEQHQAVALRVESDKSAFQDCAILGHQDSLYTHSLRQFFKDCTVAGTVDFIFGNSAAMFQTCNIVVRVGQMNGSSTRLLTAQGRIDPGQKTSLVFQNCSVYGTPEYNALQRAQPTQHRVYLGRPWKQYSRTVFIYTYMSEIVQPQGWSPWKGQFALDTLMDAEYGSYGPGAANVSQRIAWSTQLSFQQAQRFSAQRLVQADSWLPAAAITYLPLV
| 125 |
P44121
|
6.5.1.1
|
ACT_SITE 41; /note="N6-AMP-lysine intermediate"; /evidence="ECO:0000255"
|
MKFYRTLLLFFASSFAFANSDLMLLHTYNNQPIEGWVMSEKLDGVRGYWNGKQLLTRQGQRLSPPAYFIKDFPPFAIDGELFSERNHFEEISTITKSFKGDGWEKLKLYVFDVPDAEGNLFERLAKLKAHLLEHPTTYIEIIEQIPVKDKTHLYQFLAQVENLQGEGVVVRNPNAPYERKRSSQILKLKTARGEECTVIAHHKGKGQFENVMGALTCKNHRGEFKIGSGFNLNERENPPPIGSVITYKYRGITNSGKPRFATYWREKK
| 254 |
A0A1U7Z270
|
6.3.4.4
|
ACT_SITE 87; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 115; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 215; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134"
|
MNLSALRLDSSPISAPQRSFNGGRNRGERSVLFLPCASGTSRKLIQCSAKAVASSSPLGVAEQTGDVLDRIGSLSQVSGVLGCQWGDEGKGKLVDILAGHFDIVARCQGGANAGHTIYNSEGKKFALHLVPSGILNEETLCIIGNGVVVHLPGLFKEIDGLESNGISCKGRILVSDRAHLLFDFHQVVDGLRESELANSFIGTTKRGIGPCYSSKMIRNGIRVSDLRHMDTFPQKLDLLLSDAASRFKGFNYGPDVLREEVERYKRFAERLEPFIADTVHVVNESLSKKEKILVEGGQATMLDIDFGTYPFVTSSSPSAGGICTGLGIAPKVLGDLVGVVKAYTTRVGSGPFPTEILGKGGDLLRLAGKEFGTTTGRPRRCGWLDVVALKYCCLINGFSSLNLTKLDVLSDLPEIRLGVSYKQIDGTPVKSFPADLHVLEQLKVEYEVLPGWQCDISSIRNYEDLPLAARQYVERIEELVGIPIHYIGVGPGRDALIFK
| 253 |
A0A1Y1I703
|
3.5.1.98
|
ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1"
|
MAPRKDRVSYFFDADVGSVYYGPNHPMKPHRLCMAHSLILGYGLHEKLEVYRPHKAYPQEFAQFHSTDYVEFLHRITPEMTDYYKDQLVRYNMGEDCPVFDGLIDFCKIYTGGTIDGAVRLNHGLCDIAINWSGGLHHAKKQEASGFCYINDLVLGILELLKYHARVLYIDIDIHHGDGVEEAFYMTDRVMTVSFHKYGDYFFPGTGDVKDIGERDGKFYAVNVPFKDGIDDAGFHKLFKPVMTKVMEIFQPGAVVLQCGADSLAGDRLGCFNLSIDGHAECVKFMKKFAVPLLVTGGGGYTKQNVARAWTYETAVLLDAQLPNELPVTEYYEYFRPDYLLKPPVNTLIDNGNAKSYLQAIKNTIMENLRAIVHAPSVQMHEVPPDSYIPEVDQDDLTSPDERFSQFQKDKMVARDDEYYEDEYDQDHDTEEPRRHA
| 184 |
Q9X1W1
|
3.1.1.29
|
ACT_SITE 18; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083"
|
MVVVGLGNPGPRYAFTRHNVGFLFLDFLKNKDWKTEKYFAWNKINLAGNEVALVKPLTYMNLSGLAMPHVLKFFSASLDDIIVVYDDVSLKLGKIRIRKKGSDGGHNGMKSIIQALGTQEIKRIRVGIGDKPEGMDLVNFVLGEFSDEEWIILNKVFEVMKEALEVILVEGIEKAMSIYNSLEVRA
| 127 |
A0A2R6W4B8
|
1.11.1.7
|
ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MAPPRTLYMLRTLTVLLLLSVDAMLMPAFAVQDDFYQTSCPDAESVIANTVNAEIDKNFKIAAGLIRMAFHDCFVEGCDGSVLLEGEDTERTAEINLTLLGFEAIDAAETAVEAVCPGVVSCADIIAYAARDSTVKLNGTGWVVQGGRKDGNVSSAAAAQNDLPLPTFDASQLIDAFAQRNLSTQQMVVLSGAHTVGVGHCNKFVERLYNFSPTNDTDPTLNATLANQLKLECPSLTFNETIEIFMETITPGQFDSNYYVDLTRQNGLFTSDQTLFEDSRTQQLVESLISEQLFDSEFGEAMRALGTVGVKTEGQVRTICSQVNA
| 14 |
B3S3A6
|
3.2.2.27
|
ACT_SITE 118; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072"
|
MQFIIENRQINCAARWLKYPYLHKLACYFTVMPQLSVSDFFKPSAGGAKRSATQAGNDTTPEKKKRGEDKGGLSPEQLKRMDENRAKALSKLMEENQVFTWTQMCTIEEIKVVILGQDPYHGPKQAHGLCFSVQKGVAIPPSLRNMYKELEQDIPEFQAPSHGDLTEWAKQGVLLLNACLTVRAGQPNSHKDKGWEKLTDAVIKWLSKNSRHIAFLLWGAYAQKKGASISKDKHLILKCAHPSPLSATRFFGCRHFSKANEYLTKNGRKPIDWAKL
| 173 |
A0A251U0N9
|
3.2.1.14
|
ACT_SITE 136; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1"
|
MNTFLLLTFVFLLASVSAQNCGTQGGNAPCSNGNCCSQYGFCGNTPDHCLPSNNCQYQCTGTTPAPSGDTVDSIITSSVFDEMLKYRNDPRCRANGFYTYTAFINAARSYNGFGTTGSAEDRRRELAAFFAQTSHETTGGWDTAPDGRFAWGYCFLREENPPSTYCTSSAYPCPQSYFGRGPIQLTNNNNYGLFGRSVNRDLINNPDLLATDPTLSFQSAIWFWMTAQDNKPSSHDVITRRWTPSAADTAAGRVSGFGVITNIINGGLECGRGQDNRVEDRIGFYRRYCTMLGVSPGDNLDCNNQTPFA
| 158 |
F7B5T3
|
3.2.1.35
|
ACT_SITE 144; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1"
|
MGVLRIQHGFVGSSGTSQVVFTFLLIPCCLTVDFRAPPIFPNTPFVWAWNAPTEHCAEKFNVPLDLSLFSLVGSPRVNVTGQNITLFYTDRLGYYPYIETKTGKLVNGGLPQSGSLTAHLDKAKADISYYIPTDHVGLAVIDWEEWRPTWVRNWQAKDIYRQQSILLVQQENAQLNVTEATKTAKTMFEKAGKSFMLETLNLGKSLKPNHLWGFYLFPDCYNHYKGSDYNGSCYDIEKRRNDGLNWLWKESTALYPSVYLNSKLKSSPLAALFVRNRVQEAIRVSKVPSAGSPLPIFTYTRPVFSDKPSEYLSQDDLVNTIGENIALGVSGTVVWGSSNLSRSMQTCTALDNHMKTTLNPYIINVTLAAKMCSQVLCQEKGVCTRKHWNSSDYLHLNPKNFAIQTGENGKYAIHGKLTLEDLQQFPQKFYCTCYANTSCKERDNIKNIGAVNVCVTNDICIDGFLNSKPGDQPPGPSSSTPPATVSPCVHGKHPKGCSKGRCSGQTISNNAQEGCRRVYPKNTSSRLYIQNKIIKTTPSSTSSVLIKFPVYIVYVLIYFPFLDLIIYLA
| 166 |
K3ZDQ6
|
3.2.1.52
|
ACT_SITE 313; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
|
MEPALRLLLVLMVFMPCTGDVNVWPMPKSVSNGKQTVFISKDLKMTVVGSNYSDEKAILRDAFGRMVAVVEQDHVISESYERSPVLVGMNVVVRSRDDELNFGVDESYSLFVPSTGHPLYAQIEAQTVFGALHALETFSQLCSFDLESRQIILRSAPWSILDSPRFPYRGLLIDTSRHYLPVPVIKRVIDSMTYSKLNVLHWHVVDEQSFPIEIPSYPKLWNGAYSYSERYTKDDAIDIVQYAEKRGVNVLAEIDVPGHALSWGVGYPSLWPSAICKEPLDVSNNFTFEVIDGILQDFSKIFKFKFIHLGGDEVNTSCWTTTPRIKEWLILNGMDETDAYRYFVLRAQKIARSYGYDIINWEEPFNNFGDKLDRNTVVHNWLGGTVAEKAVAAGLRCILSKQESWYLDHLDAPWEGFYMNEPLANIYKPEQQRLILGGEVCMWGEQVDASDIQQTIWPRAAAAAERLWTPIEKIATNTSMVAPRLARFRCLLNQRGVAAAPLVGYGRSAPSDPGSCISQ
| 170 |
Q6P0R4
|
3.5.4.5
|
ACT_SITE 73; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1"
|
MEDQKMMHELINGLNGHLLGIKELTRKSQEAKKFAYCPYSKFRVGAALLTHDGTVFTGCNVENACFNLGICAERVAISKAVSEGYRDFKAIAIASDMCENFISPCGGCRQFMREFGSNWEVYLSKPDGSYVEMTVEELLPASFGPEDLKMKKANIRNEF
| 187 |
Q9HXM8
|
3.5.4.33
|
ACT_SITE 79; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00972"
|
MRVTKLISNGKGYPTVKGVRPIIDRSRDPHFMREALAEAEKAAALGEVPVGAVLVREGEIIGRGFNRPISSHDPSAHAEMLAIRMAAAEAGNYRLPGSTLYVTLEPCSMCSGLLVHARIQRLVYGTVEPKSGAVESRGRFFEQEHLNHRVMVEGGVLAEECSQALSAFFRARREAAKKPRED
| 186 |
A0A1U8A4S3
|
5.1.3.3
|
ACT_SITE 190; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 323; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
|
MANFSPFFCFVFAAFALINISSAHGVKVYEIKKGNFSVKLTNWGATILSVVVPDKNGKLDDIVLGYDTLEAYKNDTSYFGAIVGRVANRIGRAQFTLNGTTYKLVANEGKNTLHGGVRGFSDVLWKVIRYVPEGHSPHVTFVYRSPDGDQGFPGNLLTTVSYTIDGEETLSVTMTAKAMDKATPVNLAQHTYWNLGGHKSGDILSETVQIFGSQITLLDSQLIPTGKIAPVKGTPYDFMQPRTVGSRIKQLSNGYDINYVLDVDEVGDDQLKKAATVYDSRSGRMMELRTSAPGVQFYTANNLKDTKGKDGAVYKAHAGLCLETGGFPDSVNHPNFPSTIVVPGKLYQHLMLYTFTTTK
| 211 |
A0A2I4E4N2
|
1.11.1.7
|
ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MHQRLFQNLYIQLLCLIFFLTMSTMASFSMASLKAGFYKKSCPSAEAIVRKAVNKAVSKNDPGIAAGLIRLHFHDCFVRGCDASVLIDSTPGNPAEKKSEANPTLLGFEVIDEAKSEIEAKCPQVVSCADILAFAARDSSYKVGGIYYEVPSGRRDGRVSLEEEPIKNLPLPFFNAKQLKENFARKGLSLDEMVTLSGAHSIGVAHCTNISPRLYSFNSTHPQDPSIDPIFARNLKAKCPPEPDSRNGSDPAVALDVLSPNKLDNKYYKDLKNHRGILTSDQTLFSSSSTKKIVWKYARNDAVWANKYAAAMVKMGSIDVLTGRQGEVRKDCRFIN
| 14 |
A0A067DSE3
|
2.3.1.41
|
ACT_SITE 188; /note="For beta-ketoacyl synthase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000447-1"
|
KTVAMSATQSENDLIITEKKEPKERRIVVTGLGVVTPLGDDAHLFHTNLLEGVTAISDIQGFDCSEFSTMLDYINLKSLSTDGWVSPKVGKKADKYMIYALVAGKKALADAGITEQVSGELDKRRCGVIIGSAMGGLHVLSDGFEAIKVSYKKMSPFCIPYSLTNTASAALAMDLGWTGPSYSINTACASSNYSILNAANLRIKGDTDIMLCGGSDGAIIPAGIAGLVACNVLSQRNSEPTKAARPWDADRDGFVMGKGAGVLLLEELEQAKKRGASIYAEILAGSLSCDAYHLTAPHPEGVGMVSCMEKALAQSGVAKEDVNYINAHAPSTRLGDLREYQAVIRCFGKNPELRMNSTKSLIGHLLGASGTAEAVATIKAIQTGWIHPNLNLENPDKDVDAKVLVGPKKERLDIKVAMSNSYGFGGHNSSILFAPYKGN
| 60 |
A0A3B6C5E9
|
1.3.5.1
|
ACT_SITE 266; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1"
|
MWRGCVSRGLSKAKASASRLFSTTSSSYTVVDHSYDAVVVGAGGAGLRAAIGLSEHGFSTACITKLFPTRSHTVAAQGGINAALGNMSEDDWRWHMYDTVKGSDWLGGQAYRCACAADRTGHAMLHTLYGQAMKHNTQFFVEYFALDLLMDNEGNCQGVIALNMEDGTLHRFRATNTILATGSGYGRAYFSATSAHTCTGDGNAMVARAGLPLQDLEFVQFHPTGIYGAGCLITEGSRGEGGILRNSEGERFMERYAPTAKDLASRDVVSRSMTMEIREGRGVGPLKDHIYLHLNHLPPEVLKERLPGISETAAIFAGVDVTKEPIPVLPTVHYNMGGIPTNYHGEVVDIKGDNPDTVIPGLMAAGEAACASVHGANRLGANSLLDIVVFGRACANRVAEISKPGDKQKLLEKGAGEKTIAWLDKLRNANGSLPTSKIRLNTQRIMQNNAAVFRTQETLEEGCQLISKAWESYHDVKISDRSLIWNSDLIETIELENLLINACITMYSAEARKESRGAHAREDFTTRDDERWMKHSLGYWENEKVRLAYRPVHMNTLDDEIESFPPKARVY
| 28 |
Q9UW15
|
1.17.4.1
|
ACT_SITE 427; /note="Proton acceptor"; /evidence="ECO:0000250"; ACT_SITE 429; /note="Cysteine radical intermediate"; /evidence="ECO:0000250"; ACT_SITE 431; /note="Proton acceptor"; /evidence="ECO:0000250"
|
MYVKKRDGRQERVQFDKITARVSRLCYGLDMNHVDPVAITQKVISGVYGGVTTAQLDDLAAETAAYMTVTHPDYAILAARIAVSNLHKQTKKQWSLVISELYNYVNPRTGKHSPMIAKDVYECVMRHKDEFDSAIVYDRDFNYQYFGFKTLERSYLLKLDGQIAERPQHMIMRVAVGIWGDDVERVIETYNLMSLKTFTHASPTLFNAGTPQPQLSSCFLVDMKEDSIEGIYDTLKTCAMISKMAGGIGLNIHRIRATGSYIAGTNGTSNGIVPMLRVFNNTARYVDQGGNKRPGAFAIYLEPWHADVFEFLDLRKNHGKEEVRARDLFLALWIPDLFMKRVEQNGQWTLMCPHECPGLADVYGDEFEALYEKYEKEGKGRKTVKAQKLWYAILEAQTETGNPFMLYKDACNRKSNQKNLGTIRSSNLCTEIIEYSAPDEVAVCNLASLALSAFIDYENASYDFKKLHEVTQVVVRNLNKIIDINHYPVKEAHNSNMRHRPIGVGVQGLADAFLALRMPFDSDAASKLNIQIFETIYHAALTASCQLAKEQGPYATYEGSPVSQGILQYDMWNVTPTNLWDWTALKADIKKYGVRNSLLLAPMPTASTSQILGNNECFEPYTSNIYQRRVLAGEFQVVNPWLLRDLVEMGLWSDAMKNRIIAEGGSIQNIQSIPNDIKALYKTVWEISQRTIVKMAADRGAFIDQSQSLNIHMREPTMGKITSMHFAGWKMGLKTGMYYLRTQAAAQPIQFTVDQEALRATDDRVAPAHSGLKKRSPPAGTYTSIVLRENTSGPRPYAQTGVSGTSTPIGTRDVPTPASTPPPTEVPETLVQSDNRPRPLVSPAKSAGFKADLPEPESPKALATDPIVKTEDIGSPLLERKEGQNEDVDEDSQERDENIYSNAPLSEQQVAACAWNPGADPSSCEMCSG
| 21 |
A0A3B6MXZ9
|
3.2.1.14
|
ACT_SITE 93; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1"
|
MVRSVALAVCAAALLLAMAAGGAAAQGVGSVITRAVYETMLPNRDNSICPAKGFYTYDAFIAAAGTFPGFGTTGSADDVKRELAAFFGQTSHETTGGPQFQWGYCFKEEKTMATSPPYYGRGPIQLTGQSNYDLAGKALKLDLVSNPNLVSTDAEVSFRTAMWFWMTAQGNKPSCHDVALRRWTPTAADTAAGRVPGYGVITNIINGGRECGKGMNPENVDRIGYYTRYCGILGTATGDNLDCYTQQNFAT
| 158 |
P10097
|
1.2.1.12
|
ACT_SITE 150; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10009"
|
MVIRVGINGFGRIGRVVFRAAQRRNDIEIVGINDLLDADYMAYMLKYDSTHGRFEGAVEVQGGALVVNGKKIRVTSERDPANLKWNEINVDVVVESTGLFLSDDTARKHIQAGAKKVVITGPSKDDTPMFVMGVNHTTYKGEAIVSNASCTTNCLAPLAKVLNDKFGIVEGLMTTVHATTATQKTVDGPSQKDWRGGRGAAQNIIPSSTGAAKAVGKIIPSLNGKLTGMAFRVPTPNVSVVDLTVRLERPATYKQICDAIKAASEGELKGILGYVDEEIVSSDINGIPLTSVFDARAGISLNDNFVKLVSWYDNETGYSNKVHDLIAHITK
| 22 |
W5M2V4
|
2.7.11.30
|
ACT_SITE 369; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037393-1"
|
TKTKCAPFYISHSNWLKIASGTPSDSFSGGTVDPFKLHLLCKFCDFEPSTCDGRSNCFSNCSKTAICEKPQEVCVSIWRKDDNNVTIETLCHDPAEKIYGLLLDDYNSTKCYMKEKKFPGSLFYVCSCTEEECNNKLIFSPEVEPPTPENSVLTVILVTLVPLLVLTVVVITVFYWYRVCRSRALGEKWDGKKPKPRKMPPLDCSEACAIMIDDDRSDSSSTHANNLNHNTELLPIELDTQAGKGRFAEVYRAKLKQNASAQFETVAVKIFPDEEYASWKNEKDIFSDINLKHENVLHFLTAEERKAEKQYWLITAFHPKGNLQEYLTRHIISWEDLWLLGGSLARGVAHLHSDHTPCGRPKVPIVHRDLKSSNILVKNDLTCCLCDFGLGLRLDPSLSVDDLANSGQVGTARYMAPEVLESRINLENIESFKQTDVYSMALVLWEMTSRCNAIGEVKEYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSGWLNHQGVQLVCATINECWDHDPEARLTAQCVAERFTEMDHMDKLSGRSCSEEKIPEDCSVSDGK
| 106 |
Q8IR79
|
2.7.11.1
|
ACT_SITE 522; /evidence="ECO:0000250"
|
MHHQQRLRANGGRGGTGLGAGSGPVSGGHSPLCAHCRGQLLPHPEEPIVMALGQQWHCDCFRCSVCEGHLHNWYFEREGLLYCREDYYGRFGDACQQCMAVITGPVMVAGEHKFHPECFCCTACGSFIGEGESYALVERSKLYCGQCYGKRSCQPADAKARITTAGKPMHSIRLVEIPKDATPGLRVDGVALDDGCPTVRITDLFCNFFLWLTSMAEQCCGAPYRIDVNLTNLHIGDRILEVNGTPVSDSSVEQIDKLIRSNEKMLQLTVEHDPVQVCRSCSQADIQRAMSASTLILPLSTSASSVEVGRERLYKTPGEQGTKARKLRQATNASTTIPPAAGATAMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCRVVQKPQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSLNNLDELVKSAVDSEISPVEKEKENMVIKPQDIPKSPHLGKDFSPSGERLRDSMRARRRQRFLGAQEERRNLTPDTESKERALKKALKKCRPFGERGYLVDLRAGAELQLEDVRDLNTYSDVDSSCDTSLNYHDVNNLPAAQEDENTVKPGKEELLEESTNKPSNQESQHHRLAIDDMRTRLNQCRSKFEHLEEASRRNFNQSQHSMKNFFKTPPVALKMFQRLEHEAAALNGGNNCPPPPPRTQRINQTPIFGRKNPPVAIVGQKLQHAESLEDLASSGVAKQLATPAPKRSKATATTKGGQSSNPPLFLPPSLNISVALNSNGNVTTTTNTNSSCPPSASDWLPKKHKLTLPLPSAQQQRTSSNHRLPMCNNKGKTLKPLPSRTGSQGIPASNCVSPTRSSRPGSPTKHLAQRHTAATAQRLTNAAATHQQQHQQQSSKTTRLNILSPEKVHRLGARLTDQKQKMREEAAATASSVGGAGCAAGTAAGSLNGHRTIGSSGTPNSAVGERRRRAAPSPPVRTHFNTRC
| 99 |
Q6L5D4
|
2.7.11.24
|
ACT_SITE 233; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
|
MAVKMRIGRRRAIQQGIAEGGFEWRRVWGCREADSRGALWELVWGERSVRERNAAGAAEEVIALFIMDEMCDPASNLEYVVEKAKCDVHRTSSAEEFFTEYGDANRYRIQEVIGKGSYGVVCSAIDLHTRQKVAIKKVHNIFEHVSDAARILREIKLLRLLRHPDIVEIKHIMLPPSRRDFKDIYVVFELMESDLHQVIKANDDLTKEHYQFFLYQLLRALKYIHTASVYHRDLKPKNILANSNCKLKICDFGLARVAFNDTPTTVFWTDYVATRWYRAPELCGSFFSKYTPAIDIWSIGCIFAEVLTGKPLFPGKNVVHQLDLMTDLLGTPSMDTISRVRNEKARRYLSSMRKKDPVPFSQKFPNADPLALKLLQRLLAFDPKDRPTAEEALTDPYFKGLSKIDREPSCQPIRKLEFEFEQKKLSKEDIRELIFQEILEYHPQLQKNYRNGRERATFLYPSAVDQFKKQFSNLEESNGSGSAIPMERKHASLPRSTTVHSTPIPPKEQPLAASLKSSRPVSDEPCKNPWVMGGFSGNIPTSSQVSQVAKPVAPGRPVGSVFPYETGSTNDPYGPRGPVMSSGYPPQQQISQAYGYHQVPARMNCVEQSQAMDAYKMHSQSQTQAYAYPNSKVTADVALDMRGSTFHHSAGSKNGSLDRMVTQTDIYTRSLNGIVAAATSAGVGTNRKVGAVPISTSRMY
| 104 |
Q75DT2
|
5.1.3.15
|
ACT_SITE 159; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 264; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"
|
MSVDADEKEVILVHPSNEKTAVKILNYGATIYSWTIDGEEQLWLSDAAKLDGSKPVRGGIPLVFPVFGKNTDDEHFSKLPQHGLARNSTWEFLGQTKENPPAVQFGLGPELANEELTALWPFDYTLVLTVELGEEHLKTEIEVVNTSTSQTLRFNWLFHTYLKIDDVEDTMVSNLKNFKTYDQLLKTSYVDRQPVVAFHEEVDRIYQQVADDRVIQIVDKGRPIHSVSRGNLPDVVVWNPWIEKSANMQDFQPKEGYQKMICIEPGHVHDFVTLQPGEKWSGYQLLSKDTLKYQAV
| 210 |
A0A7M7T5W0
|
1.8.1.4
|
ACT_SITE 491; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2"
|
MSLLPVANRAGRCLSTVNHVHKLSRCSTSALWRGQRRHMASVEEQDLVVIGSGPGGYVAAIKAAQLGLKTTCVEKNDTLGGTCLNVGCIPSKALLNNSHLYHMAASKDFKSRGIDVGDIKLNLPKMMGQKSDAVKGLTNGVAHLFKQNSVTRIQGHGKVMGPNEVAVLHPDGKIKEVVKTKNILIATGSEVTPFPGIEVDEKTVVSSTGALSLERVPDHMVLIGGGVIGLELGSVWQRLGAKVTAVEFLGHIGGVGIDMEMAKNFQRILTKQGIKFKLNTKVTGATRTGDDISVSVESVKDPNKKEDLQCDTLLVCVGRRPYTNNLGLEELGISLDERGRIPVDNRFATSVPSVFAIGDCIQGPMLAHKAEDEGIIAVEGMAGGPVHIDYNCVPSVIYTHPEVAWVGKTEEQLKEEGIKYKVGKFPFAANSRAKTNGDTDGLVKMLSDAATDRILGAHIIGSGAGEMINEAALAMEYGASCEDVARVCHAHPTVSEAFREANMAAYSGKAINF
| 36 |
A0A3B6RDP8
|
3.1.1.11
|
ACT_SITE 190; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MKKLALRRLLAIAISVVALFISFTPETSHRCDAAQTVVKSVFVDQTGRGDFKTIQAAIDSVPFGNNQWTRVHVAAGTYTEKVTVPFNKSFILLEGEGRLQTSIEWADHAGGSSTTADTPTFASHADDFMARDITFKNTYDGANLAQAVAALVDGDRSSFYGCGFFSVQDTLCDMAGRHYYKNCVIGGAVDFIFGNARSIFQGCDLWTGKLTKTLGSITAHGRDTDKDDTAFVFKQCKIGGFMPIYLGRPWRDYARVIFYQTNMSIVVDRQGWDIWNSKGKEGLLTMVESECTGAGSNTTERVPWAKQLSGKEIARFVSLSYISPDGWLDAQPR
| 125 |
Q96MT1
|
2.3.2.27
|
ACT_SITE 537; /evidence="ECO:0000250|UniProtKB:Q5SWK7"
|
MAAKEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLSNNPLFQYKYLALNMHYVGYILSVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVRSELEFAYEGPMYLEPLSMNRFTTALIGQLVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLPIATKEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHLKNSSQLPGLGTEPVLQPHAGAEQNVMFQEGTEPPGQEHTPGTRIQEGSRDNNEYIARRPDNQEGAFDPKEYPHSAKDEAHPVESA
| 66 |
A0A061EN86
|
1.11.1.7
|
ACT_SITE 100; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
|
MVRIRITRYDQESSKAMRRGSRVLRTTKKMSPSAQMASLFTSLLFLLAIFFISPAVSLPLKIGFYQKTCPSAEAIVMSTVKAALASDPGIPAALIRLHFHDCFVRGCDASILLDSTPSNRAEKDSMGNKGVQGFQVIDEAKAKIEAQCPNTVSCSDILAFAARDSVTLAGGLHYGVPSGRGDGRVSSAAEVTQNLPDAFFNVTQLKQNFARKGLSMEEMVTLSGAHSIGDSHCSSFSKRLYSFDKTSTQDPSMDPSYARLLKAKCPRPLNTRTGPDPLVPFDPVTPNRLDNNYYKNLKSSKGLLASDQVLWNSMLTRKFVKENVNHPSAWAAKFAAAMVHMGSIDVLTGKQGEIRRNCRVVN
| 14 |
A0A0K9P6R2
|
3.1.1.11
|
ACT_SITE 348; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
|
MSPQSMLLLFLIVFIYQTPSSISTQDFDFLITLGDAVDQLKDMITLVSSFSDLLWGGDKLSASAVADCLDLLDLSIDETTWAISATQEFSKRSAASASSIVRHQHDLRSWLSAVLSNQDTCNQGLSHINILLKTLIVQGMETVTSLISYGLSGIPGEYYGGEARGRNLMGVVENGYPGWVEEMDRRLLHRALGEYMNVDMVVAADGSGDFKTISSAVKSVPDKSEQRIVIYVKSGVYKENVYVHKDKWNIMLIGDGIGSTVITGDRNFVDGWTTYRSATFAVDGKKFMAKDITFENTAGPKKYQAVALRSNSDFSVFYRCEMDGYQDTLYPHSLRQFYRECIIKGTVDFIFGNGAVVFQTCQILARKPLPHQKNTITAQCRNDSNQNTGFTIQYSNITVDEVLEAEVNSLTETYIGRPWRKYSKTVVMESYLGPAIHPKGWLEWNRQKSSLSTLYYAEYKNFGPGSRLENRVNWPGFHVIETIEEAMKFTVTQLIDGESWLPGTGVKYVDIPM
| 125 |
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