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Analytical Chemistry
|
2025_6
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/Analytical Chemistry/2025_6.png
|
D
|
98
|
MAC_Bench/ACS/Story/Analytical Chemistry/1987_13.txt
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vitg
|
1987_13.txt
|
ptamer
|
MAC_Bench/ACS/Story/Analytical Chemistry/2024_37.txt
|
clip
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2024_37.txt
|
, wherein we substitute the target-specific antibody with designer DNA nanostructure-based molecular probes for recognizing the SARS-CoV-2 virus via multivalent, pattern-matching interactions.
|
MAC_Bench/ACS/Story/Analytical Chemistry/2024_45.txt
|
vith
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2024_45.txt
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The inclusive droplet digital ELISA (iddELISA) expands the boundaries of digital immunoassays by incorporating all types of bead encapsulations into the analysis, enhancing assay efficiency, and simplifying operations. This innovative approach holds great promise for the early detection of low-abundance biomarkers.
|
MAC_Bench/ACS/Story/Analytical Chemistry/2025_6.txt
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groundtruth
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2025_6.txt
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train
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ACS Energy Letters
|
2025_2
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/ACS Energy Letters/2025_2.png
|
B
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The cover depicts magnetic couplings between redox-active transition metal centers in typical intercalation-type battery electrodes, which lead to characteristic electron spin and magnetic properties. Such properties can be probed as the battery operates using electron paramagnetic resonance (EPR) and magnetometry and provide insight into the crystal and electronic structure, composition, defect chemistry, and working principles of rechargeable batteries.
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MAC_Bench/ACS/Story/ACS Energy Letters/2020_1.txt
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clip
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2020_1.txt
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in situ
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MAC_Bench/ACS/Story/ACS Energy Letters/2025_2.txt
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groundtruth
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2025_2.txt
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Metal halide perovskites are generating enormous excitement for use in both photovoltaic and light-emission applications. The cover art shows the perovskite crystal structure capable of strongly absorbing light to generate electrical power as a solar cell or efficiently generating light emission from electrical power as a light-emitting device. There are still a number of losses in these materials that particularly limit the light-emission processes. Eliminating these loss pathways will lead to photovoltaic and light-emission devices approaching their efficiency limits. Credit: Dr. Matthew T. Klug.
|
MAC_Bench/ACS/Story/ACS Energy Letters/2017_6.txt
|
ave_2
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2017_6.txt
|
A collage of perovskite covers featured in previous issues of ACS Energy Letters. To commemorate ten years of perovskite photovoltaics, researchers from around the world tell their own stories and how they became interested in perovskite research. Cover art in the collage appeared on the following covers: Top row, left to right: 2016, 1 (6); 2018, 3 (8); 2017, 2 (5) Middle row, left to right: 2017, 2 (12); 2017, 2 (4); 2017, 2 (11) Bottom row, left to right: 2017, 2 (7); 2018, 3 (9); Suppl. cover art 2019, 4 (1)
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MAC_Bench/ACS/Story/ACS Energy Letters/2019_9.txt
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vitg
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2019_9.txt
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train
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Caner Cell
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42_7
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Which of the following options best describe the cover image?
|
MAC_Bench/Cell/Cover/Caner Cell/42_7.png
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D
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On the cover: Defeating a complex disease like cancer will require a united, concerted
effort by different types of people from diverse backgrounds who can bring together
distinctive experiences and ways of thinking. This issue of Cancer Cell features Voices, Letter, and Commentary pieces discussing the importance of diversity
and immigration for the future of cancer research.
|
MAC_Bench/Cell/Story/Caner Cell/38_4.txt
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clip
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38_4.txt
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On the cover: In this issue of Cancer Cell, Sagnella et al. (pp. 354–370) show that nanocells attack tumors by delivering a
cytotoxin and engaging multiple arms of the immune system. The cytotoxin binds and
kills tumor cells. Dendritic cells and macrophages engulf dying tumor cells and display
tumor-associated antigens that are recognized by CD8+ T cells. Activated CD8+ T cells
home to the tumor, recognizing and killing live tumor cells and augmenting the anti-tumor
effect. The cover is an artistic rendition of the dual roles of the cyto-immunotherapeutic
nanocells. Design: Himanshu Brahmbhatt and Jennifer MacDiarmid. Image: Martin Hale,
Animated Biomedical Productions.
|
MAC_Bench/Cell/Story/Caner Cell/37_4.txt
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vitg
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37_4.txt
|
On the cover: With the festive red and gold theme of this cover, the Cancer Cell editorial team celebrates the new year and kicks off the celebration of Cancer Cell’s 20th anniversary, which will span 2022 with many exciting articles.
|
MAC_Bench/Cell/Story/Caner Cell/40_12.txt
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vith
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40_12.txt
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On the cover: Liu et al. reveal the evolutionary dynamics and tumor-immune interplay in acral melanoma (AM).
The cover metaphorically represents the progression from AM in situ (AMis) to invasive AM (iAM). AMis tumors (grapes near vines) are homogeneous (green),
and iAM close to them are also green, indicating monoclonal dissemination. During
vertical invasion, some grapes change in shape and color, representing increased heterogeneity.
These abnormal tumors (purple grapes) are more invasive, and APOE+CD163+ macrophages
(birds) are attracted to promote tumor invasion. Image credit: Hengkang Liu and Ruidong
Xue.
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MAC_Bench/Cell/Story/Caner Cell/42_7.txt
|
groundtruth
|
42_7.txt
|
train
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NATURE GENETICS
|
56_7
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/NATURE GENETICS/56_7.png
|
D
|
Mendel and memories
In celebration of the 200th anniversary of Gregor Mendel’s birth and the 30th anniversary of the launch of Nature Genetics, we look both forwards and backwards at how far the genetics field has come. This cover image is inspired by the cover of the first issue of Nature Genetics in 1992.
Image and Cover Design: Valentina Monaco.
|
MAC_Bench/Nature/Story/NATURE GENETICS/54_6.txt
|
vitg
|
54_6.txt
|
Peanut global phenotypic variation
Chloroplast and whole-genome sequencing of Arachis accessions sheds light on peanut evolutionary history and phenotypic diversification.
See Zheng et al.
Image: Nastasic/DigitalVision Vectors/Getty. Cover design: Laoise Mac Gabhann.
|
MAC_Bench/Nature/Story/NATURE GENETICS/56_4.txt
|
clip
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56_4.txt
|
Dynamic single-cell genetic effects
A new statistical method known as GASPACHO identifies nonlinear dynamic genetic effects using single-cell RNA-sequencing data.
See Kumasaka et al.
Image: Alamy. Cover Design: Tulsi Voralia.
|
MAC_Bench/Nature/Story/NATURE GENETICS/55_7.txt
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ave_2
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55_7.txt
|
Engineering crop polyploid genomes
Generation of clonal gametes in tomato enables polyploid genome design through controlled combination of pre-defined genome haplotypes.
See Wang et al.
Image: Rainer Franzen, Yazhong Wang and Rob Kesseler. Cover design: Tulsi Voralia
|
MAC_Bench/Nature/Story/NATURE GENETICS/56_7.txt
|
groundtruth
|
56_7.txt
|
val
|
Nature Structural & Molecular Biology
|
31_11
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/Nature Structural & Molecular Biology/31_11.png
|
C
|
NSMB’s 30th anniversary
To celebrate Nature Structural & Molecular Biology’s 30th anniversary, our cover features original artwork that was submitted by our reader Pedro Rebelo-Guiomar for our cover competition.
See Rebelo-Guiomar and Editorial
IMAGE CREDIT: Pedro Rebelo-Guiomar, University of Cambridge. COVER DESIGN: Allen Beattie
|
MAC_Bench/Nature/Story/Nature Structural & Molecular Biology/31_12.txt
|
vitg
|
31_12.txt
|
Ordered water molecules in respiratory complex I
A cryo-EM structure of Y. lipolitica mitochondrial complex I reveals ordered water molecules involved in proton relay and catalysis.
See Article by Grba and Hirst
Cover Image: Laszlo Podor / Moment / Getty. Cover Design: Erin Dewalt.
|
MAC_Bench/Nature/Story/Nature Structural & Molecular Biology/27_3.txt
|
ave_1
|
27_3.txt
|
Understanding writers and readers of ubiquitylation
In this issue, we feature seven studies that progress our understanding of writers and readers of ubiquitylation, in addition to a Historical Perspective and several Comment pieces reflecting on the ever-expanding roles of this critical modification.
See Editorial
IMAGE CREDIT: Linda Marie Caldwell / iStock / Getty Images Plus. COVER DESIGN: Allen Beattie
|
MAC_Bench/Nature/Story/Nature Structural & Molecular Biology/31_11.txt
|
groundtruth
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31_11.txt
|
Targeting a SARS-CoV-2 pseudoknot
A cryo-EM structure of the pseudoknot-forming SARS-CoV-2 frameshift stimulation element guides development of antisense oligonucleotides that impair virus replication.
SeeZhang et al.
Image:Filip Obr / Alamy Stock Photo. Cover Design: Bethany Vukomanovic
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MAC_Bench/Nature/Story/Nature Structural & Molecular Biology/28_4.txt
|
clip
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28_4.txt
|
train
|
Trends in Genetics
|
41_3
|
Which of the following options best describe the cover image?
|
MAC_Bench/Cell/Cover/Trends in Genetics/41_3.png
|
C
|
Transposable elements comprise a large part of the genome in most organisms. At first
thought to serve no beneficial purpose to the host and considered “junk” DNA, recent
work has shown these elements to be important players in shaping the genome, often
providing benefit to the host. This Special Issue of Trends in Genetics is composed of several articles highlighting the progress that has been made in recent
years in the study of these mobile genetic elements. The cover image shows a cartoon
depicting the rise of transposable elements from their original “junk” status. Image
courtesy of Alper Uzun, PhD, www.biocomicals.com.
|
MAC_Bench/Cell/Story/Trends in Genetics/33_3.txt
|
ave_2
|
33_3.txt
|
In this special issue of Trends in Genetics, we turn the lens on ourselves. The articles
this month focus on human genetics, with topics ranging from resources and methods
to make the most of the explosion of sequencing data to evolutionary questions about
mutation rates and how selection acts through pregnancy.
|
MAC_Bench/Cell/Story/Trends in Genetics/29_4.txt
|
vitg
|
29_4.txt
|
Sex chromosomes can cause expression imbalances between males
and females that are often corrected through dosage compensation. In this issue,
Kalita and Keller Valsecchi review our current understanding of dosage compensation
across diverse insect species beyond traditional model organisms. They discuss the
evolutionary dynamics of sex chromosomes, the variety of molecular mechanisms that
achieve balanced expression, and propose approaches to uncover regulatory pathways
in non-model insects. Illustration by Agata Kalita.
|
MAC_Bench/Cell/Story/Trends in Genetics/41_3.txt
|
groundtruth
|
41_3.txt
|
This Special Issue of Trends in Genetics covers a range of themes related to organogenesis, from the formation of the central
nervous system to the evolution of the insect eye. The articles in this issue highlight
the commonalities of organ formation that are shared across species and kingdoms,
and provide insight on the mechanisms that underlie organogenesis, including regulation
by non-coding RNA and cell expansion driven by polyploidy. Cover image: iStock/kreatiw.
|
MAC_Bench/Cell/Story/Trends in Genetics/31_7.txt
|
clip
|
31_7.txt
|
train
|
ACS Medicinal Chemistry Letters
|
2025_2
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/ACS Medicinal Chemistry Letters/2025_2.png
|
A
|
Preventing the release of the fusion peptide is a challenging approach to target influenza A virus hemagglutinin. This study explores the putative binding site of the pinanamine-containing compound M090. Computational tools were used to examine the feasibility of the binding mode and the structure–activity relationships. The results open clues for the design of future small-molecule inhibitors targeting hemagglutinin.
|
MAC_Bench/ACS/Story/ACS Medicinal Chemistry Letters/2025_2.txt
|
groundtruth
|
2025_2.txt
|
PROTACs: a matter of vector. Two PROTACs based on the same BAZ2A/BAZ2B bromodomain ligand and linker differ only by attachment point to the VHL ligand. Albeit subtle, this difference is crucial: dBAZ2 (blue) degrades both BAZ2A and BAZ2B, while dBAZ2B (orange) is a BAZ2B-selective degrader.
|
MAC_Bench/ACS/Story/ACS Medicinal Chemistry Letters/2025_1.txt
|
ave_3
|
2025_1.txt
|
X-ray crystal structure of the carboplatin-loaded ferritin nanocage (PDB code 5MIJ). Pt centers coordinate to His49 and His132, on the inner surface of the Ft nanocage. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00025. View the article.
|
MAC_Bench/ACS/Story/ACS Medicinal Chemistry Letters/2017_9.txt
|
vith
|
2017_9.txt
|
Mixed aryl acyloxy prodrugs readily cross the cell membrane, release a charged phosphonate ligand that binds to the intracellular domain of BTN3A1, and efficiently stimulate gd T cell proliferation. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00245. View the article.
|
MAC_Bench/ACS/Story/ACS Medicinal Chemistry Letters/2017_4.txt
|
clip
|
2017_4.txt
|
train
|
Industrial & Engineering Chemistry Research
|
2024_33
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_33.png
|
C
|
2O4 Octahedrons” (DOI: 10.1021/acs.iecr.7b04445); and W. Li et al., “Anisotropic Turbulent Mass Transfer Model and Its Application to a Gas-Particle Bubbling Fluidized Bed” (DOI: 10.1021/acs.iecr.7b03715)
|
MAC_Bench/ACS/Story/Industrial & Engineering Chemistry Research/2018_47.txt
|
vitg
|
2018_47.txt
|
Lemon juice, a readily available and biodegradable natural substance, was used to prepare carbon dots (CDs) in one step by a microflow approach. The derived CDs
|
MAC_Bench/ACS/Story/Industrial & Engineering Chemistry Research/2024_42.txt
|
vith
|
2024_42.txt
|
The cover sketches the challenge of integrating multiple scales into a process model and how this can be performed with compartment models. These compartment models are applied to an industrial rotary dryer shown in the figures and the background.
|
MAC_Bench/ACS/Story/Industrial & Engineering Chemistry Research/2024_33.txt
|
groundtruth
|
2024_33.txt
|
Schematic diagram of photogenerated electron transfer mechanism of tetracycline degradation by
|
MAC_Bench/ACS/Story/Industrial & Engineering Chemistry Research/2023_23.txt
|
clip
|
2023_23.txt
|
train
|
Macromolecules
|
2024_13
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/Macromolecules/2024_13.png
|
B
|
On the cover: Macroscopically aligned helical polyacetylene film was synthesized through acetylene polymerization under monodomain structured chiral nematic liquid crystal reaction field with applied magnetic field of 5 T. See page 5943. View the article.
|
MAC_Bench/ACS/Story/Macromolecules/2010_11.txt
|
clip
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2010_11.txt
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Schematic representation of a four-dimensional scanning transmission electron microscopy experiment, where the electron beam (in green) scans across a block copolymer sample (in black/white) recording diffraction patterns (below) that reveal the orientation (rainbow colors) of the semicrystalline crystalline structure (shown top left as the atomic structure).
|
MAC_Bench/ACS/Story/Macromolecules/2024_13.txt
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groundtruth
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2024_13.txt
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On the cover: The delicate interplay of structure and dynamics in macromolecular and supramolecular systems leads to increasing complexity and functionality. This poses considerable challenges for their physical characterization. No experimental or theoretical/simulation approach alone can provide complete information. Instead, a combination of techniques is called for, and conclusions should be supported by results provided by as many complementary methods as possible. See p 5479. View the article.
|
MAC_Bench/ACS/Story/Macromolecules/2010_12.txt
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vitg
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2010_12.txt
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Self-immolative polymers provide an opportunity for controlled deconstruction of macromolecular architectures in response to environmental stimuli. See page 7317. View the article.
|
MAC_Bench/ACS/Story/Macromolecules/2012_7.txt
|
ave_2
|
2012_7.txt
|
test
|
Nature Reviews Rheumatology
|
20_11
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_11.png
|
A
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Inspired by the Review on p81.
Cover design: Steven Hall
|
MAC_Bench/Nature/Story/Nature Reviews Rheumatology/20_11.txt
|
groundtruth
|
20_11.txt
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Inspired by the Review on p257.
Cover design: S.Harris/Springer Nature Limited
|
MAC_Bench/Nature/Story/Nature Reviews Rheumatology/17_8.txt
|
clip
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17_8.txt
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Inspired by the Review on p449.
Cover design: S.Harris/Springer Nature Limited
|
MAC_Bench/Nature/Story/Nature Reviews Rheumatology/17_5.txt
|
vitg
|
17_5.txt
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In our January issue: articles on myofibroblasts in fibrotic diseases, drug repurposing in patients with rheumatic diseases, and behavioural economics in rheumatology.
Image of a bone tissue engineering scaffold implanted in a femur defect model. Image supplied by Betül Aldemir Dikici, University of Sheffield. Cover design: Susanne Harris.
|
MAC_Bench/Nature/Story/Nature Reviews Rheumatology/16_12.txt
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vith
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16_12.txt
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train
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Science
|
387_6732
|
Which of the following options best describe the cover image?
|
MAC_Bench/Science/Cover/Science/387_6732.png
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A
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COVER A breeding ruff male (Calidris pugnax) in alert posture scans the breeding area for mating opportunities at Liminka Bay, Finland. Ruff males deploy one of three mating tactics that differ in aggressive and courtship behaviors. Differences in aggression between tactics are tied to concentrations of circulating androgens, which are modulated by the actions of a single gene. See pages 358 and 406.
Photo: Jari Peltomäki/Finnature
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MAC_Bench/Science/Story/Science/387_6732.txt
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groundtruth
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387_6732.txt
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COVER Whiskers at the snout are instrumental for the rat to explore the external world. During development, sensory information provided by the whiskers is critical for the formation of their representation in the brain. Minlebaev et al. show how this process is controlled by gamma oscillations in developing neuronal networks. See P. 226. Image: Henrik Sorensen/Getty Images
|
MAC_Bench/Science/Story/Science/334_6053.txt
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vitg
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334_6053.txt
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COVER Science, like the rest of society, has been swept up in the storms caused by social media. This special news section looks at how scientists study and fight mis- and disinformation, how harassment and intimidation have spiked during the COVID-19 pandemic, and how researchers use Twitter to inform the public and share their findings with colleagues. See page 1332.
Illustration: Davide Bonazzi/Salzmanart
|
MAC_Bench/Science/Story/Science/375_6587.txt
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clip
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375_6587.txt
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COVER In early 2020, governments worldwide introduced lockdowns to curb the spread of COVID-19. These lockdowns severely altered human mobility, with many people confined to their homes. In response, animals such as the coyote (Canis latrans) traveled longer distances and occurred closer to roads. These changes suggest that animals can modify their behavior in response to rapid changes in human mobility. See pages 1008 and 1059.
Photo: Shannon Stapleton/Reuters
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MAC_Bench/Science/Story/Science/380_6649.txt
|
vith
|
380_6649.txt
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train
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Med
|
5_9
|
Which of the following options best describe the cover image?
|
MAC_Bench/Cell/Cover/Med/5_9.png
|
B
|
On the cover: This issue of Med explores the applications of CAR T cell therapies beyond hematologic malignancies,
including solid tumors and autoimmune diseases. A Q&A with Fabian Müller (University Hospital Erlangen) covers the latest developments in the field. A Review
from Liu et al. discusses emerging combination strategies using CAR T cells in solid tumors, while
Shu et al. review the exciting potential of CAR technology in non-neoplastic diseases. Fischbach et al. present a Case Report describing the safety and feasibility of CD19-targeted CAR
T-cell therapy in the first two patients with progressive multiple sclerosis, with
an accompanying Viewpoint from Rankin and Shah highlighting the new frontiers of CAR T cell therapies. Cover credit: Keith Chambers/Science
Photo Library via Getty Images.
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MAC_Bench/Cell/Story/Med/5_7.txt
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vitg
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5_7.txt
|
On the cover: Camrelizumab, an anti-PD-1 immunotherapy drug, shows promise in treating
a range of cancers, including hepatocellular carcinoma, esophageal squamous cell carcinoma,
and Hodgkin lymphoma. In a phase 2 clinical trial, Pan et al. demonstrated the safety and feasibility of pre-operative camrelizumab with microwave
ablation for treating early breast cancer. The combined therapy enhanced the cytotoxic
and effector memory functions of peripheral CD8+ T cells. The treatment also activated MHC class I and interferon signaling pathways
in monocytes, suggesting their contribution to the improved CD8+ T cell activity. Cover credit: JUAN GARTNER/Science Photo Library via Getty Images.
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MAC_Bench/Cell/Story/Med/5_9.txt
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groundtruth
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5_9.txt
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On the cover: In this issue, Millen et al. (pp. 290–310) describe and characterize
a head and neck cancer organoid biobank. Using patient-derived models, they subsequently
study the effects of therapies that are combined in the clinic and validate genetic
biomarkers for treatment response. They explore whether these models can predict therapy
response of corresponding patients. The cover shows an abstract representation of
organoids derived from different patients (in different colors) that can be screened
for drug sensitivity to indicate which drug works best (the labels attached to the
Petri dishes). As such, organoid screens can generate patient-specific profiles or
“fingerprints.” Cover art: Else Driehuis.
|
MAC_Bench/Cell/Story/Med/4_8.txt
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ave_1
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4_8.txt
|
On the cover: In this issue, Wu et al. investigate the role of dendritic cells (DCs)
within the tumor immune microenvironment and their impact on immunotherapy outcomes
in patients. Using data from clinical trials and mouse models, they identify a specific
functional DC state characterized by CCL19 expression that can augment the antitumor
activity of CD8+ T cells and is associated with favorable immunotherapy responses.
Intratumoral and circulating CCL19 levels may be used as a marker to predict immunotherapy
efficacy. On the cover, DCs (in pink) within the tumor microenvironment produce CCL19,
which acts on CD8+ T cells (in blue) to enhance their antitumor effectiveness. Cover
art: Sonhita Chakrabarty.
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MAC_Bench/Cell/Story/Med/4_7.txt
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clip
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4_7.txt
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train
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Current Biology
|
34_2
|
Which of the following options best describe the cover image?
|
MAC_Bench/Cell/Cover/Current Biology/34_2.png
|
A
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On the cover: A group of yellow-billed long-tailed finches (Poephila acuticauda) perch on a tree branch. In this issue, Hooper et al. demonstrate the role of selection in the evolution of bill coloration, a carotenoid-based
color trait that distinguishes a pair of hybridizing subspecies. Yellow alleles, like
the ones carried by the birds in this image, regulate the oxidative ketolation reaction
required by vertebrates to metabolize red carotenoid pigments from dietary precursors.
Adaptive introgression of these derived and largely recessive yellow alleles is ongoing
and suggests that the frequent evolutionary transitions between carotenoid color states
observed in nature may have a simple genetic basis. Photograph © Col Roberts; used
with permission.
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MAC_Bench/Cell/Story/Current Biology/34_2.txt
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groundtruth
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34_2.txt
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On the cover: Red factor and yellow canaries. Many species of birds in nature can
biochemically modify yellow dietary carotenoids to red ketocarotenoids to produce
red coloration of bills and feathers. In this issue, Lopes et al. (pages 1427–1434)
and Mundy et al. (pages 1435–1440) independently dissect the genetic basis of red
coloration in the canary and zebra finch, respectively. Both groups identified a gene
encoding a cytochrome P450 enzyme (CYPJ19) that mediates this yellow-to-red conversion in birds. Lopes et al. further identified
a second genomic region that is required for the production of red coloration in feathers
and that localizes to a cluster of genes involved in development of the integument.
These findings have important implications for studies of sexual selection, speciation,
and social signaling in birds. Photo credit: Rebecca Koch; used with permission.
|
MAC_Bench/Cell/Story/Current Biology/26_14.txt
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clip
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26_14.txt
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On the cover: In this issue, Drury et al. deploy a new modeling approach and show that the availability of open niches influences
the pace of phenotypic evolution across all birds. This image shows a little bee-eater
(Merops pusillus), an African invertivore (one of the groups with a particularly strong response to
changing niche availability). Photo by Jonathan Drury.
|
MAC_Bench/Cell/Story/Current Biology/34_22.txt
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vith
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34_22.txt
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On the cover: With this issue, Current Biologycompletes its twentieth year. Since its origins as a journal publishing “dispatches
from the front lines of biology,” Current Biologyhas continuously expanded in terms of both paper formats and breadth of subjects covered.
We hope the journal will continue to evolve and look forward to the exciting biology
that the next twenty years may bring for us and our readers. For more, see the editorial
by current Editor Geoffrey North and founding Editor Peter Newmark (pages R1049–R1051).
|
MAC_Bench/Cell/Story/Current Biology/20_1.txt
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vitg
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20_1.txt
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train
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Nature Reviews Cardiology
|
21_6
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/Nature Reviews Cardiology/21_6.png
|
D
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DEI in Cardiology, inspired by the Roadmap on p765.
Cover design: Vicky Summersby.
|
MAC_Bench/Nature/Story/Nature Reviews Cardiology/19_2.txt
|
clip
|
19_2.txt
|
Blood pressure variability, inspired by the Review on p643.
Cover design: Vicky Summersby.
|
MAC_Bench/Nature/Story/Nature Reviews Cardiology/19_3.txt
|
vith
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19_3.txt
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Cardiovascular involvement in long COVID, inspired by the Review on p314.
Cover design: Vicky Summersby.
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MAC_Bench/Nature/Story/Nature Reviews Cardiology/19_8.txt
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vitg
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19_8.txt
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Immune checkpoints, inspired by the Review on p443.
Cover design: Vicky Summersby
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MAC_Bench/Nature/Story/Nature Reviews Cardiology/21_6.txt
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groundtruth
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21_6.txt
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train
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Nature Photonics
|
18_3
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Which of the following options best describe the cover image?
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MAC_Bench/Nature/Cover/Nature Photonics/18_3.png
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B
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Scanning near-field optical microscopy reveals the structure of plasmon sheet and edge modes in graphene disk and rectangular nanoresonators.
Letter p239
IMAGE: ELLA MARUSHCHENKO
COVER DESIGN: BETHANY VUKOMANOVIC
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MAC_Bench/Nature/Story/Nature Photonics/10_9.txt
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ave_1
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10_9.txt
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Fluorescence-lifetime image scanning microscopy
Integrating a single-photon avalanche detector (SPAD) array into a confocal laser scanning microscope yields a twofold increase in the localization accuracy for single-molecule localization microscopy. The cover shows an artistic impression of the SPAD array detector with microlenses, where the two disks/shaded Gaussians depict the emission of two different fluorescent molecules hitting the detector array.
See Radmacher et al.
Image: Alexey Chizhik. Cover design: Bethany Vukomanovic
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MAC_Bench/Nature/Story/Nature Photonics/18_3.txt
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groundtruth
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18_3.txt
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The onset of turbulence and coherence loss in fibre laser radiation is studied and found to originate from the clustering of solitons.Letter p783News & Views p767Interview p840IMAGE: ARTEM OVCHARENKO, TURITSYNA ET AL.COVER DESIGN: TOM WILSON
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MAC_Bench/Nature/Story/Nature Photonics/7_3.txt
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clip
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7_3.txt
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The advent of super-resolution imaging schemes that allow optical imaging beyond the diffraction limit of light is revolutionizing sample analysis in the biological and physical sciences. This issue features a special focus on the topic.
Cover design by Stefan Hell.
Progress article by Stefan W. Hell et al .
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MAC_Bench/Nature/Story/Nature Photonics/3_6.txt
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vitg
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3_6.txt
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train
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Science Signaling
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2007_377
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Which of the following options best describe the cover image?
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MAC_Bench/Science/Cover/Science Signaling/2007_377.png
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D
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ONLINE COVERThis week, Caratti et al. report that, in the absence of activating ligands, the glucocorticoid receptor (GR) associates with complexes containing RAS and inhibits RAS activation. The image shows HEK293T cells expressing mCherry-tagged KRAS (red) and EGFP-tagged GR (green). Nuclei are stained blue. Image: Caratti et alMAC_Bench/Science Signaling
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MAC_Bench/Science/Story/Science Signaling/15_726.txt
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ave_1
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15_726.txt
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ONLINE COVER This week features a Research Article that describes a method for identifying active signaling pathways in cancer tissue samples and shows that this information may enable more effective treatment. The image shows the signal produced by proximity ligation assay for the interaction of EGFR and GRB2 (red), cytokeratin (green), and nuclei (blue). [Image: Matthew A. Smith, Moffitt Cancer Center]
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MAC_Bench/Science/Story/Science Signaling/8_359.txt
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vitg
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8_359.txt
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ONLINE COVER This week, Tóth et al. show that when the endocytosis of a G protein–coupled receptor (GPCR) is prevented, even partial agonists of the β-arrestin pathway become full agonists, suggesting that receptor localization plays a role in determining biased GPCR signaling. The image shows the fluorescent signal of β-arrestin2 in control (left) and stimulated (right) HEK 293A cells in which a GPCR was activated by two different agonists (top and bottom) with different efficacies in activating β-arrestin signaling. Credit: Tóth et alMAC_Bench/Science Signaling
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MAC_Bench/Science/Story/Science Signaling/17_842.txt
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clip
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17_842.txt
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COVER This week features a Perspective on focal adhesions, protein complexes that link the cell interior to the extracellular matrix. The image illustrates a model of focal adhesion proteins functioning as a molecular clutch. [Image: Yu-Li Wang, University of Massachusetts Medical School]
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MAC_Bench/Science/Story/Science Signaling/2007_377.txt
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groundtruth
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2007_377.txt
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train
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Science Immunology
|
10_104
|
Which of the following options best describe the cover image?
|
MAC_Bench/Science/Cover/Science Immunology/10_104.png
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D
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ONLINE COVER Boosting Locally Buffs Up Vaccine-Induced Immunity. This month’s cover shows an immunofluorescence image of a germinal center in a mouse lymph node 5 weeks after a priming immunization with influenza hemagglutinin. Primed B cells fate-mapped for AID expression (green) are present in the central area of a follicle of IgD-expressing B cells (red) near CD21/35-expressing follicular dendritic cells (blue). Kuraoka et al. observed more fate-mapped memory B cells in lymph node germinal centers when booster immunizations were given at the same tissue site as the original immunization rather than on the opposite side. Credit: Masayuki Kuraoka and Ryutaro Kotaki/Duke University
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MAC_Bench/Science/Story/Science Immunology/7_71.txt
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vitg
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7_71.txt
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ONLINE COVER Chemical Confinement of Germinal Center B Cells. This month's cover is an immunofluorescence image showing the spleen of a preimmunized mouse injected one day earlier with B cells (in green) expressing the human P2RY8 receptor. Gallman et al. observed that retention of the transferred B cells in germinal centers, defined by a network of follicular dendritic cells (in red), was maintained by a repulsive gradient of S-geranylgeranyl-ʟ-glutathione (GGG), a P2RY8 ligand exported from B cells in the outer follicle via the Abcc1 transporter protein. A Focus commentary by Stoler-Barak and Shulman explores how GGG gradients are established and maintained to enable germinal centers to support the affinity maturation of B cell–encoded immunoglobulins. [CREDIT: GALLMAN ET ALMAC_Bench/Science IMMUNOLOGY]
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MAC_Bench/Science/Story/Science Immunology/6_60.txt
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ONLINE COVER Teaming Up to Defend. Depicted here are CD141+ dendritic cells (DCs, green), which resist infection by enveloped viruses (yellow spheres), and CD1c+ DCs (orange), which are susceptible to infection. Silvin et al. report that CD141+ DCs acquire viral antigen from infected CD1c+ DCs and prime antiviral T cell responses. [CREDIT: RENAUD CHABRIER, WWW.RENAUDCHABRIR.COM]
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MAC_Bench/Science/Story/Science Immunology/2_13.txt
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clip
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2_13.txt
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ONLINE COVER Immune Hotspots in Multiple Myeloma. Multiple myeloma (MM) is a plasma cell malignancy that develops in the bone marrow but can expand as breakout lesions into neighboring soft tissues as the disease progresses. Using single-cell and spatial multiomics, Lutz et al. compared the cellular composition of bone marrow–confined MM and breakout lesions in patients with newly diagnosed MM. Within breakout lesions, “immune islands” containing focal accumulation of immune cells served as sites for T cell clonal expansion and tumor genomic diversification. This month’s cover image, obtained using multiplexed imaging, shows an immune island within a breakout lesion from a patient with MM. Myeloid cells (yellow), NK cells (orange), and T cells (pink) surround vascular cells (green) and diffusely infiltrate areas dominated by plasma cells (blue). Credit: Johanna Wagner/German Cancer Research Center and National Center for Tumor Diseases Heidelberg and Niels Weinhold/Heidelberg University Hospital and German Cancer Research Center
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MAC_Bench/Science/Story/Science Immunology/10_104.txt
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groundtruth
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10_104.txt
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train
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Current Biology
|
34_5
|
Which of the following options best describe the cover image?
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MAC_Bench/Cell/Cover/Current Biology/34_5.png
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C
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On the cover: The early evolution of Cyanobacteria and oxygenic photosynthesis has
been difficult to retrace, partly because very few extant representatives are available
from Gloeobacteria, an isolated lineage that is sister to the rest of Cyanobacteria.
In this issue, Rahmatpour et al. (pages 2857–2867) isolate and describe a new and
deeply diverged species of Gloeobacteria, namedAnthocerotibacter panamensis, in pure culture. This new species exhibits a suite of unique morphological, physiological,
and genomic features, and thus holds the key to piecing together the major transitions
in Cyanobacteria evolution. The cover image shows a rendering of a group ofAnthocerotibacter rod-shaped cells.
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MAC_Bench/Cell/Story/Current Biology/31_12.txt
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ave_0
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31_12.txt
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On the cover: Old oak branches laden with epiphytes in the coastal region of South
Carolina, USA. As primary producers, plants are the backbone of nearly all of Earth’s
ecosystems, forming a complex web of interactions with microbes, fungi, and animals—as
well as other plants. Because of their limited mobility, plants interact with other
organisms in peculiar ways. This special issue presents a wide-ranging set of reviews,
primers, quick guides, and essays that highlight the many ways in which plants interact
with those around them—from microbial symbionts to animal herbivores to human societies.
Image credit: Daniela Duncan/Getty.
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MAC_Bench/Cell/Story/Current Biology/33_14.txt
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clip
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33_14.txt
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On the cover: Common pond skaters (Gerris lacustris) on the surface of a river in the Lake District, UK. These predatory insects exploit
the high surface tension of water to skate across the water's surface, a process facilitated
by their long, hydrophobic legs and the distribution of their weight over a large
surface area, providing a clear example of how physical principles impact biology.
Our special issue on the collaboration between physics and biology brings together
reviews, essays, primers, and other formats to showcase the various ways in which
physical concepts and approaches have enhanced our understanding of the living world.
Photo: Ashley Cooper/Getty Images.
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MAC_Bench/Cell/Story/Current Biology/34_5.txt
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groundtruth
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34_5.txt
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On the cover: With this issue, Current Biologycompletes its twentieth year. Since its origins as a journal publishing “dispatches
from the front lines of biology,” Current Biologyhas continuously expanded in terms of both paper formats and breadth of subjects covered.
We hope the journal will continue to evolve and look forward to the exciting biology
that the next twenty years may bring for us and our readers. For more, see the editorial
by current Editor Geoffrey North and founding Editor Peter Newmark (pages R1049–R1051).
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MAC_Bench/Cell/Story/Current Biology/20_1.txt
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vitg
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20_1.txt
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train
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Science Translational Medicine
|
17_786
|
Which of the following options best describe the cover image?
|
MAC_Bench/Science/Cover/Science Translational Medicine/17_786.png
|
D
|
ONLINE COVER Transforming Lung Cancer. The cover illustrates a lung adenocarcinoma cell (pink) transitioning to an intermediate state (purple) that can then transdifferentiate into a lung squamous cell carcinoma cell (red) or small cell lung carcinoma cell (blue). This issue of Science Translational Medicine features a Focus article by Alvaro Quintanal-Villalonga, the winner of the 2024 AAAS Martin and Rose Wachtel Cancer Research Award, which is given each year to a young scientist who has made important contributions to the field of cancer research. Credit: Fathema Z. Uddin
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MAC_Bench/Science/Story/Science Translational Medicine/16_760.txt
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ave_0
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16_760.txt
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ONLINE COVER Covering 10 Years of Translation. The image shows a collection of Science Translational Medicine covers, one for each year of the journal's publication. To celebrate Science Translational Medicine's 10th anniversary and a decade of exciting translational research, we are launching with this issue a special Focus series "Science Transforming Medicine". Focus articles in this series will highlight key translational research advances in different fields achieved since the journal began publishing in October 2009. The first Focus article in this series by Zmora et al. discusses the rapid pace of advances in microbiome research and the challenges ahead for developing microbiota-based therapies. [CREDIT: SCIENCE TRANSLATIONAL MEDICINE]
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MAC_Bench/Science/Story/Science Translational Medicine/11_477.txt
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vitg
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11_477.txt
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ONLINE COVER An Adjuvant Advance. The cover shows a mouse inguinal lymph node after vaccination with the BNT162b2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine adjuvanted with a lipid nanoparticle-encapsulated mRNA encoding interleukin (IL)–12p70. The lymph node was stained for naïve (yellow) and germinal center (green) B cells, T cells (magenta), and follicular dendritic cells (blue) to visualize the vaccine-elicited immune response. Immunity elicited by SARS-CoV-2 mRNA vaccines have been shown to wane over time, particularly in older individuals. To improve immune durability, Brook et al. adjuvanted the BNT162b2 SARS-CoV-2 vaccine with a mRNA encoding IL-12p70, which amplified vaccine responses even at lower vaccine doses. The authors also developed a strategy to limit expression of the mRNAs to muscle, potentially reducing systemic reactogenicity after vaccination. Together, these data show that mRNA vaccines, like their protein counterparts, benefit from adjuvantation. Credit: Brook et alMAC_Bench/Science Translational Medicine
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MAC_Bench/Science/Story/Science Translational Medicine/16_757.txt
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clip
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16_757.txt
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ONLINE COVER Identity Crisis. The cover shows YFP (green), insulin (red, overlap with YFP in yellow), and a DNA counterstain (blue) in the pancreas of a 3-week-old mouse model of Wolfram syndrome (WS) lacking the Wfs1 gene. WS is an inherited disorder that results in multiple systemic symptoms including pancreatic β cell loss. Amo-Shiinoki et al. found that although WS mice were born with substantial insulin-producing β cells, as pictured, progressive dedifferentiation of β cells occurred after weaning, resulting in a mixed population of insulin- and glucagon-producing cells. The β cell lineage loss was attributable to impaired oxidative glycolysis and lowered adenosine triphosphate content, and was targetable by deletion of the endoplasmic reticulum stress–response protein Txnip. This study increases our understanding of mechanisms of β cell loss and highlights a potential therapeutic strategy for WS. Credit: Amo-Shiinoki et alMAC_Bench/Science Translational Medicine
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MAC_Bench/Science/Story/Science Translational Medicine/17_786.txt
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groundtruth
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17_786.txt
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train
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Crystal Growth & Design
|
2024_4
|
Which of the following options best describe the cover image?
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MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_4.png
|
C
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An Fmoc-CF hydrogel incorporated inside a lysozyme crystal is able to protect the enzyme molecules from the radicals generated by X-rays during data collection avoiding local radiation damage (Cryst. Growth Des. 2019, 19, 4229–4233).
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MAC_Bench/ACS/Story/Crystal Growth & Design/2019_5.txt
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vith
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2019_5.txt
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The cover shows two conformers of resorcinol and a single crystal of resorcinol polymorphs α grown in a high-pressure diamond-anvil cell. Resorcinol polymorphs were determined in the 1930s, but their metastable phases, symmetry, and densities have remained puzzling. The high-pressure structures reveal the mechanism destabilizing polymorphs α and β, involving the molecular conformation and directions of hydrogen bonds
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MAC_Bench/ACS/Story/Crystal Growth & Design/2019_3.txt
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clip
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2019_3.txt
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supramolecular polymeric motifs are combined in one crystal to produce the platforms for multimodal thermally tuned blue-to-green and/or NIR photoluminescence. The background of the cover image was generated by artificial intelligence (AI) using Microsoft Copilot.
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MAC_Bench/ACS/Story/Crystal Growth & Design/2024_4.txt
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groundtruth
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2024_4.txt
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With the exploration of tyramine's role as a prolific coformer, this study delves into its extensive co-crystallization capabilities with diverse acids, analyzing crystal structures and electron density to uncover the key factors driving its versatility in multicomponent crystal formation.
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MAC_Bench/ACS/Story/Crystal Growth & Design/2025_4.txt
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vitg
|
2025_4.txt
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train
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Chemical & Biomedical ImagingOpen Access
|
2024_10
|
Which of the following options best describe the cover image?
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MAC_Bench/ACS/Cover/Chemical & Biomedical ImagingOpen Access/2024_10.png
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B
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molecular fingerprint
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MAC_Bench/ACS/Story/Chemical & Biomedical ImagingOpen Access/2024_3.txt
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ave_1
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2024_3.txt
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A label-free 3D tomogram of COVID-19 microclots was recorded using a digital holotomographic microscope.
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MAC_Bench/ACS/Story/Chemical & Biomedical ImagingOpen Access/2024_10.txt
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groundtruth
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2024_10.txt
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A universal, rapid and large-scale synthesis strategy for chiral fluorescent
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MAC_Bench/ACS/Story/Chemical & Biomedical ImagingOpen Access/2024_1.txt
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vitg
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2024_1.txt
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The cover design is inspired by the fluorogenic reaction and click reaction. As depicted in the image, nonluminous planets interact with each other to generate new small planets that emit intense fluorescent light, enabling diverse research applications. View the article.
|
MAC_Bench/ACS/Story/Chemical & Biomedical ImagingOpen Access/2023_3.txt
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clip
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2023_3.txt
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test
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Nature Neuroscience
|
27_1
|
Which of the following options best describe the cover image?
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MAC_Bench/Nature/Cover/Nature Neuroscience/27_1.png
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A
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Focus on single-cell genomics in neuroscience
Single-cell and single-nucleus genomics pave the way for a comprehensive understanding of the nervous system and its diverse cell populations. Realizing this potential depends on meticulous planning, execution, and analysis. In this Focus Issue, three reviews from leaders in the field summarize best practices. The cover illustration symbolizes this effort with two hands pulling on a string, unraveling the complexity of the nervous system.
See Gokce et al. , Nowakowski et al. and Liddelow et al.
Image: Tyas Widayati. Cover design: Marina Spence
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MAC_Bench/Nature/Story/Nature Neuroscience/27_1.txt
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groundtruth
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27_1.txt
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Focus on neuroscience methods
In this focus issue on neuroscience methods we present a series of reviews, perspectives and commentaries that highlight advances in methods and analytical approaches and provide guidelines and best practices in various areas of neuroscience.
Image: Jennie Vallis. Cover design: Marina Corral Spence.
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MAC_Bench/Nature/Story/Nature Neuroscience/23_1.txt
|
vith
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23_1.txt
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This month's special issue of Nature Neuroscience features a series of reviews and opinionated pieces on the theme of spatial cognition.
|
MAC_Bench/Nature/Story/Nature Neuroscience/20_2.txt
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vitg
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20_2.txt
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Shu and colleagues show that two sodium channel subtypes, a high-threshold Nav1.2 and a low-threshold Nav1.6, are asymmetrically distributed in the axon initial segment (AIS). This asymmetrical distribution explains many of the unique properties of the AIS, including its generation of backpropagating action potentials. Cover design by Jiafeng Zhao.959996
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MAC_Bench/Nature/Story/Nature Neuroscience/12_5.txt
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clip
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12_5.txt
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train
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Nature Reviews Neurology
|
20_5
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/Nature Reviews Neurology/20_5.png
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C
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Single-cell technologies and brain disease, inspired by the Review on p346.
Cover design: Philip Patenall
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MAC_Bench/Nature/Story/Nature Reviews Neurology/19_7.txt
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ave_2
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19_7.txt
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Microglia in the tumour microenvironment, inspired by the Review on p243.
Cover design: Philip Patenall.
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MAC_Bench/Nature/Story/Nature Reviews Neurology/17_9.txt
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vitg
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17_9.txt
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Neurology in the midnight sun, inspired by the Q&A on p453.
Cover design: Amie Fernandez
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MAC_Bench/Nature/Story/Nature Reviews Neurology/20_5.txt
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groundtruth
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20_5.txt
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Synaptic degeneration in Alzheimer disease, inspired by the Review on p19.
Cover design: Philip Patenall
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MAC_Bench/Nature/Story/Nature Reviews Neurology/19_12.txt
|
clip
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19_12.txt
|
test
|
NATURE REVIEWS NEUROSCIENCE
|
25_10
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_10.png
|
C
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'Building a big brain project' by Jennie Vallis, inspired by the Viewpoint on p659.
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MAC_Bench/Nature/Story/NATURE REVIEWS NEUROSCIENCE/14_4.txt
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clip
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14_4.txt
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‘Neuroconnectionism’, inspired by the Perspective on p431
Cover design: Jennie Vallis
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MAC_Bench/Nature/Story/NATURE REVIEWS NEUROSCIENCE/24_6.txt
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ave_1
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24_6.txt
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‘Light and cognition’, inspired by the Review on p159.
Cover design: Jennie Vallis
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MAC_Bench/Nature/Story/NATURE REVIEWS NEUROSCIENCE/25_10.txt
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groundtruth
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25_10.txt
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‘Brain activity on the move’, inspired by the Perspective on p347.
Cover design: Jennie Vallis
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MAC_Bench/Nature/Story/NATURE REVIEWS NEUROSCIENCE/24_7.txt
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vitg
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24_7.txt
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train
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Journal of Chemical Theory and Computation
|
2024_22
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/Journal of Chemical Theory and Computation/2024_22.png
|
B
|
The
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MAC_Bench/ACS/Story/Journal of Chemical Theory and Computation/2020_4.txt
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vitg
|
2020_4.txt
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Solvent effects on the conformational dynamics and response to light excitation of multinuclear mixed valence metal complexes can be unveiled by mixed quantum classical approaches, based on molecular dynamics simulations carried out with quantum mechanically derived force-fields.
|
MAC_Bench/ACS/Story/Journal of Chemical Theory and Computation/2024_22.txt
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groundtruth
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2024_22.txt
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for clinical decision support. J. Chem. Theory Comput. 2017, 13, 210–222.
|
MAC_Bench/ACS/Story/Journal of Chemical Theory and Computation/2017_9.txt
|
vith
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2017_9.txt
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A machine learning approach LINES is used to accelerate sampling of binding sites around TIM3 and P26. The strongest binding site is targeted and found to support stable binding in a pose that we hypothesize blocks TIM3-GAL9 binding, a reaction that is known to suppress immune responses.
|
MAC_Bench/ACS/Story/Journal of Chemical Theory and Computation/2023_7.txt
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clip
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2023_7.txt
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train
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Nature Reviews Earth & Environment
|
5_1
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/Nature Reviews Earth & Environment/5_1.png
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B
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The planetary boundaries framework outlines a safe operating space for humanity according to key Earth System dynamics. This Perspective proposes the addition of a green water planetary boundary based on root-zone soil moisture, and demonstrates that widespread green water modifications now present increasing risks to Earth System resilience. See Wang-Erlandsson et al.
Image: kakub1n/Getty images. Cover design: Carl Conway.
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MAC_Bench/Nature/Story/Nature Reviews Earth & Environment/3_7.txt
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vitg
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3_7.txt
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Land-use and climate changes can reduce the resilience of river deltas to regime shifts in channel morphodynamics, estuarine turbidity and the state of coastal wetlands. This Review discusses how these regime shifts can be triggered, monitored and prevented.
Universal Images Group North America LLC / Alamy Stock Photo. Cover design: Carl Conway
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MAC_Bench/Nature/Story/Nature Reviews Earth & Environment/5_1.txt
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groundtruth
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5_1.txt
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Mangroves, tidal marshes and seagrass meadows have historically been lost or degraded, threatening their ability to store carbon and provide ecosystem services. This Review details the global potential of blue carbon ecosystem protection and restoration in climate change mitigation, through carbon sequestration and co-benefit production. See Macreadie et al. [link to ‘Macreadie et al’ 10.1038/s43017-021-00224-1]
Image: Marie Hickman/Getty Images. Cover design: Denis Mallet.
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MAC_Bench/Nature/Story/Nature Reviews Earth & Environment/2_1.txt
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clip
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2_1.txt
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Non-perennial segments of rivers undergo cycles of flowing, non-flowing and dry phases, influencing ecosystem dynamics and services across the river network. This Review describes the occurrence, ecology and future of these intermittent and ephemeral flows and highlights the importance of protecting these segments.
Image credit: Anton Petrus / Getty Images. Cover design: Carl Conway.
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MAC_Bench/Nature/Story/Nature Reviews Earth & Environment/4_1.txt
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vith
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4_1.txt
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train
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Med
|
5_6
|
Which of the following options best describe the cover image?
|
MAC_Bench/Cell/Cover/Med/5_6.png
|
B
|
On the cover: This issue of Med explores the applications of CAR T cell therapies beyond hematologic malignancies,
including solid tumors and autoimmune diseases. A Q&A with Fabian Müller (University Hospital Erlangen) covers the latest developments in the field. A Review
from Liu et al. discusses emerging combination strategies using CAR T cells in solid tumors, while
Shu et al. review the exciting potential of CAR technology in non-neoplastic diseases. Fischbach et al. present a Case Report describing the safety and feasibility of CD19-targeted CAR
T-cell therapy in the first two patients with progressive multiple sclerosis, with
an accompanying Viewpoint from Rankin and Shah highlighting the new frontiers of CAR T cell therapies. Cover credit: Keith Chambers/Science
Photo Library via Getty Images.
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MAC_Bench/Cell/Story/Med/5_7.txt
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vitg
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5_7.txt
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On the cover: Chemotherapies are currently dosed based on a patient's height and weight,
using an equation from 1916 to estimate their body surface area. This method leads
to variability in pharmacokinetics, potentially causing increased toxicities and decreased
efficacy. Personalized dosing could improve the patient's experience by providing
a more accurate dose, reducing side effects and increasing drug efficacy. In this
issue of Med, DeRidder et al. develop a closed-loop automated drug infusion regulator (CLAUDIA) system to address
this challenge by ensuring the drug reaches the target concentration regardless of
other factors. This illustration depicts a positive treatment experience, with patients
walking unbothered by their personalized chemotherapy dose represented by colorful
IV bags floating like balloons. Recovery is gentler, and daily life is less impacted
by chemotherapy. Cover credit: Virginia E. Fulford.
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MAC_Bench/Cell/Story/Med/5_6.txt
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groundtruth
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5_6.txt
|
On the Cover: The events of 2020 have highlighted the existing health disparities
among people of different races and ethnicities throughout the world and the urgent
need for equitable access to healthcare solutions. The January 2021 issue of Med explores the complex relationships between diversity, race and health. Cover design
by Kip Lyall. Adapted from ArdeaA/iStock via Getty Images.
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MAC_Bench/Cell/Story/Med/2_12.txt
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vith
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2_12.txt
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On the Cover: While monoclonal antibodies against SARS-CoV-2 have received emergency
approval for treatment, they do not persist in serum for extended periods and must
be administered intravenously, which affects their use. In this issue, Cobb et al.
(pp. 188–203) report the development of ADM03820, a neutralizing antibody cocktail
engineered for increased stability and decreased interaction with immune cells. Intramuscular
administration of ADM03820 in rhesus macaques protects them against SARS-CoV-2 challenge
in the lungs and nasopharynx in a dose-dependent manner. These results suggest that
the neutralizing capacity of ADM03820 alone is capable of protection against infection,
even when potentially beneficial immune cell interactions are eliminated. The data
can also be used to estimate neutralizing antibody titers capable of preventing infection
in non-human primate models. The extended half-life of the neutralizing Ab cocktail
in serum makes it a promising candidate for preventing SARS-CoV-2 infection in high-risk
and immunocompromised individuals. Cover designed and created by Salvatore Fabbiano.
Cover art adapted from mrsim/DigitalVision Vectors via Getty Images and Elena Fomina/iStock/Getty
Images Plus via Getty Images.
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MAC_Bench/Cell/Story/Med/3_10.txt
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clip
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3_10.txt
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train
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Acta Pharmacologica Sinica
|
45_3
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/45_3.png
|
A
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Cover Credit: CircNSD1 acts as ceRNA of miR-429-3p to promote the target gene SULF1 expression and activate Wnt/β-catenin pathway signaling to enhance fibroblasts proliferation and collagen deposition leading to cardiac fibrosis. (DOI 10.1038/s41401-024-01296-7). See the article in pages 2092-2106.
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Cover Credit: DZ2002, a reversible inhibitor of type III S-adenosyl-L-homocysteine hydrolase, attenuates TNF-α-induced NF-κB signaling by suppressing the degradation and phosphorylation of IκB, along with NF-κB p65 phosphorylation and nuclear translocation. Additionally, DZ2002 inhibits the activation of molecules in the STAT3-PI3K-Akt pathway, suppressing the secretion of inflammatory cytokines and pro-angiogenic factors. These findings strongly support DZ2002's promising therapeutic potential for dry eye disease (DED).
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Cover Credit: Mechanisms of Takeda G protein-coupled receptor-5 (TGR5) agonist on inhibiting intestinal epithelial cell apoptosis and ameliorating ulcerative colitis. Activation of TGR5 by OM8 enhanced cAMP/PKA signaling, which led to upregulation of c-FLIP expression, and subsequently suppressed JNK phosphorylation, thereby antagonizing TNF-α induced intestinal epithelial cell apoptosis.
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Cover Credit: Urolithin A, as a fruit-derived natural product, protects against atherosclerotic plaque vulnerability by pleiotropic mechanisms, including promoting NO production, inhibiting YAP/TAZ-dependent endothelial inflammation as well as lowering lipid levels. Doi:10.1038/s41401-024-01317-5. See the article in pages 2277–2289
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NATURE ENERGY
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Now we are five
Nature Energy launched its first issue five years ago. To mark the occasion, this month we take a look back at some of our past content and catch up with some of our early authors.
See Editorial
Image: Anton Eine/Alamy Stock Photo. Cover Design: Thomas Phillips.
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The power to respond
Energy is used in the delivery of many functions of humanitarian aid, from shelter, lighting and transport, to clean water, sanitation, and medical assistance. This Focus issue explores how thinking around energy is changing as the need for sustainable energy solutions in refugee camps intensifies and as humanitarian crises become more protracted.
Image: Practical Action/David Nkurunziza. Cover Design: Allen Beattie.
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Fuel for the future
Our energy systems are undergoing large-scale changes as we try to overcome many societal and environmental challenges. Doing this successfully requires the efforts of many different researchers across a range of technologies and systems, each of which faces their own issues and concerns for the future.
See Armstrong et al. 1, 15020 (2016).
IMAGE: poliki/iStock/ThinkstockCOVER DESIGN: Alex Wing
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Clean cooking transition experiences
Adapting to cleaner cooking fuels from more polluting options may be experienced differently by different groups across various stages of the energy transition. Kar et al. analyse survey data on household-level energy use in Ghana as the country shifts towards cleaner cooking fuels. Given wide heterogeneity, they propose a stage-based framework to support policy interventions.
See Kar et al.
Image: Kypros / Getty Images. Cover design: Thomas Phillips
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Trends in Cancer
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10_10
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We invite readers to explore the newest addition to the Trends collection Trends in Cancer, which aims to cover a range of topics in cancer research including the latest developments
in basic, translational and clinical sciences, pharma R&D, technology, ethics, and
policy. The inaugural issue of Trends in Cancer tackles the big questions in cancer research today by leading researchers in the
field. The cover depicts an image of a crab or cancer in Latin. The name cancer comes from early observations by Greek physician Hippocrates
of finger-like projections emanating from the diseased mass, calling to mind the shape
of a crab (carcinos in Greek, and later, cancer in Latin). The concept was developed by Danielle Loughlin and Kip Lyall, and the
image was designed by Kip Lyall.
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Variations in cancer incidence fuel the debate on the relative contributions of intrinsic
vs extrinsic factors. On pages 409–415 in this issue, Thomas et al. add an extra piece to the puzzle by exploring the concept of evolutionary ecology
in oncogenesis, and discuss how an organ ecosystem and its contribution to Darwinian
fitness determines vulnerability to cancer. Cover design by Eric Pélatan.
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Aging is a strong predictor of cancer, which is often viewed as a senescence-related
disease. On pages 169–172 in this issue, Thomas et al. reflect on cancer from an evolutionary biology perspective, and argue for reassessing
the “senescence view” considering that cancer is a strong selective force early on
in the lifespan of organisms. Cover design by Eric Pélatan.
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Many therapeutic strategies that are positive in preclinical mice
experiments fail in human clinical trials due to biological differences between mice
and humans. In this issue, Joshi et al. propose using pigs as alternative animals for
preclinical testing due to their many similarities shared with humans. In particular,
the
Oncopig model is likely to play a key role in developing novel cancer therapeutics.
Cover image courtesy of gettyimages/Danielle D. Hughson.
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Macromolecules
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C
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Self-immolative polymers provide an opportunity for controlled deconstruction of macromolecular architectures in response to environmental stimuli. See page 7317. View the article.
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Polyelectrolyte complexation is associative phase separation of oppositely charged polyelectrolytes in aqueous media. See Macromolecules, 2018, 51 (8), pp 2988–2995. View the article.
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L-Glutamic acid acts as molecular glue connecting αlanine units to produce fluorescent poly-Glu-Ala. View the article.
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On the cover: Macroscopically aligned helical polyacetylene film was synthesized through acetylene polymerization under monodomain structured chiral nematic liquid crystal reaction field with applied magnetic field of 5 T. See page 5943. View the article.
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Trends in Microbiology
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33_2
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This themed issue of Trends in Microbiology explores different aspects of microbial endurance and how microbes endure and flourish
in the environments they find themselves in. We examine how bacteria and viruses establish
chronic infections – from adaptation and population diversity, to the latent reservoir
in HIV as well as how this might be eliminated, and reactivation of latency. We discuss
how bacteria respond to stressful conditions from responses from the immune system
to antimicrobials and how the stress response is regulated. We also look at endurance
in beneficial interactions and how a stable gut microbiota is maintained and how stress
can act as a cue in symbiosis. Finally, we explore what endurance might mean for the
field of microbiology and how this might evolve in the 21st Century. The cover image by Kip Lyall playfully imagines what microbial endurance
might look like if microbes ran in marathons.
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This themed issue of Trends in Microbiology examines the role that metabolism plays
in microbial life ranging from how microbes obtain energy to how microbes can alter
the metabolism of their host and use host-derived metabolites to their advantage.
The cover image was inspired by the hypothesis that perhaps pathogenic bacteria might
just be looking for food, which is discussed by Rohmer et al. on pages 341–348. Cover
image courtesy Rodolphe ‘Rodho’ Grandviennot.
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In this issue on broad concepts in microbiology we celebrate the 25th anniversary
of Trends in Microbiology and explore the concepts that have grown through the history of the journal and the
emerging areas within these topics. On pages 376–385, Ariel Amir and Nathalie Balaban
review recently invoked methods which rely on the statistics of cell size and cell
cycle durations to gain insights into the regulation of and control over biological
processes within cells, through the combination of single-cell level measurements
and quantitative stochastic models. The cover image shows an artist's depiction of
a variable microbial cell population. Cover image from Equinox Graphics.
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In this issue, Gerber-Tichet et al. provide an update on the expanding
role of the function of Toll-like receptor 4 (TLR4), a germline-encoded pattern
recognition receptor (PRR). The archetypal role TLR4 is the detection bacterial wall
components, including lipopoly- and lipo-oligo-saccharides (LPS and LOS). The cover
shows antigen-presenting cells (APCs), which are the sentinels of the immune system,
containing cell surface dimers of TLR4 dimers, one of the ten members of the TLR
family. However, TLR4 is not a one trick pony – it can also generate anti-viral innate
immune responses via TRIF-related adaptor molecule-associated signalling directly
or
indirectly (e.g., Ebola or adenovirus via an alpha-defensin bridge, respectively).
Image courtesy: Conception and design by Elina Gerber-Tichet and EJ Kremer.
BioRender® was used to generate an initial template.
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ACS Physical Chemistry Au
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2024_6
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Which of the following options best describe the cover image?
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D
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The cover features the kinetics of tetracyanoethylene on a copper surface at two different temperatures. For increasing dosages, the system undergoes a thermodynamically driven phase transition from lying to standing. As this transition notably changes the physical properties of the interface, we study how to kinetically inhibit this change. Based on first principles, we predict that molecules can be trapped in a lying orientation in the temperature range of 110
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This front cover depicts the artwork created by Tianruo Shen, the first chemist from a family of medical professionals. This cover and accompanying Editorial are part of the
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The cover features the interaction at the nanoscale between amine functionalized polymers and sodium ions competing for mica binding sites. By varying the concentration of the species in play, for the first time, we systematically observe a trend in the macroscopic adhesion measurements, which can be predicted well by a competing Langmuir isotherm model. Moreover, our work provides a visualization of the ionic species at the solid–liquid interface together with thermodynamic information on their kinetic parameters.
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Amino acids will be observed remotely, the diffuse interstellar bands will be linked to molecular carriers, and direct spectral observations of exoplanetary atmospheres will produce clear chemical signals.
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Nano Letters
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2025_8
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Which of the following options best describe the cover image?
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B
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The cover art shows a STM image of bilayer FeSb films epitaxially grown on a SrTiO3(001) substrate with a well-ordered Kagome lattice clearly revealed (inset). View the article.
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The cover art depicts a microtubule structure with intact and open segments exposing the inner surface. Atomic force microscopy reveals a high-resolution view, showing an undulating arrangement of protofilaments (PFs) with alternating height variations, caused by different structural orientations and conformations of αβ-tubulin dimers in adjacent PFs.
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This cover shows a three-dimensionally rendered ultra-high vacuum scanning tunneling microscope image of 10,12-pentacosadiynoic acid (PCDA) molecular chains on an epitaxial graphene surface. PCDA is used as a template for growing sub-10 nm oxide nanostructures on graphene via atomic layer deposition. Justice M. P. Alaboson, Chun-Hong Sham, Sumit Kewalramani, Jonathan D. Emery, James E. Johns, Aparna Deshpande, TeYu Chien, Michael J. Bedzyk, Jeffrey W. Elam, Michael J. Pellin, and Mark C. Hersam, pp 5763. View the article.
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This cover shows the friction between a pair of silicon anvils in the non-Amontons (high pressure) and non-Coulomb (low sliding speed) regime. The nanometer-scale silicon crystalline anvils are brought into contact and form a decrystalized junction due to high pressure. The lower anvil moves laterally at low sliding speed, resulting in superplastic shear deformation of the junction. The results are expected to lead to a better understanding of quasi-static friction under high pressure and open a new window onto geoscience, materials science, and nanotechnology. Tadashi Ishida, Takaaki Sato, Takahiro Ishikawa, Masatsugu Oguma, Noriaki Itamura, Keisuke Goda, Naruo Sasaki, and Hiroyuki Fujita, p 1476.
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Immunity
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57_3
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On the cover: 2019 marks the 25th anniversary of Immunity. The cover for this anniversary issue was designed to celebrate our authors, reviewers,
and readers and was created with photos submitted by immunology labs from around the
world (download the high-resolution image here). These photos, along with information about each lab, are compiled in a companion
website (https://www.cell.com/immunity/community) that we hope will serve as a resource to foster connections within the immunology
community. We thank all of the labs that participated in this effort—it has been fun!
In this issue, we also present to you fourteen commissioned reviews on the theme of
cytokines. These articles highlight the progress made in both the understanding of
these fundamental effectors of immunity and the translation of these insights into
the clinic. Cover design by Kavitha Scranton.
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On the cover: The generation of affinity matured antibodies to T cell-dependent (TD)
antigens occurs in dynamic structures called germinal centers (GCs). TD antibody formation
in GCs requires both a specialized set of T cells referred to as T follicular helper
(Tfh) cells in addition to cognate B cells. In this issue of Immunity, three papers (Choi et al. [pages 932–946], Kerfoot et al. [pages 947–960], and Kitano
et al. [pages 961–972]) characterize Tfh cell and B cell dynamics within the GC reaction.
Tfh cells are thought to provide “help” to B cells leading to the differentiation
of B cells within the GC. A common message among the papers is that this relationship
between B and T cells in the GC has a reciprocal nature, with B cells in turn providing
“help” in the maintenance of Tfh cells. This reciprocity is represented on the cover
by a handshake. © iStockphoto.com/caracterdesign]
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On the cover: 2024 marks the 30th anniversary of Immunity! To celebrate this milestone with the immunology community, we hosted an open call
for cover submissions for our special anniversary issue and are grateful to have received
beautiful and creative submissions from across the globe! The winning design featured
on the cover of this anniversary issue was designed by Yun Hsuan Elena Lin, a PhD
candidate in the laboratory of Dr. John Chang at the University of Californa, San
Diego. In her illustration, immune cells are depicted as flowers flourishing from
vases in the shape of the number 30. The stalks of the flowers are comprised of DNA,
RNA, mitochondria, antibodies, blood vessels, lymphatics, neuronal and glial cells,
microbes, and more, highlighting advances in immunology research over the past decades.
Model organisms populate the image as well, recognizing their key contributions in
driving substantial advances in human immunology. The bouquet captures the diversity
of immunological research published by Immunity, painted over a backdrop of dawn that symbolizes the exciting discoveries to come. In this issue, we present a collection of review and perspective articles on innate
immunity with a focus on pattern recognition. Rather than recognizing unique aspects
of a pathogen, the innate immune system uses families of receptors that recognize
shared features of potential threats to the host. Likewise, sensing of endogenous
molecular patterns enables maintenance of health. Throughout this collection of articles,
we explore the latest understanding of how the innate immune system evolved to ensure
that the body responds appropriately to the myriad of microbes in the environment
while maintaining regulation of homeostatic functions, how these mechanisms can go
awry in disease, and the prospects for harnessing these insights into the development
of new therapies.
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On the cover: The thymus involutes as we age, leading to reduced numbers of recent
thymic emigrant (RTE) naive T cells in circulation. Bohacova, Terekhova et al. examine human RTEs in a cohort of 158 individuals, providing insight into the impact
of age on RTE profile and functional potential and defining CD38 expression as a marker
of RTEs. RTEs—newly generated naive T cells—are depicted as a flock of migrating birds
emerging from a cloud (thymus). Having completed maturation, RTEs transition into
the bloodstream and eventually into the tissues, as evoked by migrating birds in search
of favorable environments. Image credit: Fishy Frog.
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Science Translational Medicine
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17_785
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Which of the following options best describe the cover image?
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ONLINE COVER Expanding Liver Gene Editing. The cover shows gene-targeted and expanded adult mouse hepatocytes (red) and a counterstain for DNA (blue). Homology-directed repair (HDR)-based techniques show promise for gene editing of liver diseases, but they do not always achieve sufficient editing of adult cells. To improve HDR-based hepatocyte editing, De Giorgi et al. created a system that conditions the liver by transiently knocking down the essential gene fumarylacetoacetate hydrolase (Fah), and then inserts a therapeutic transgene of choice alongside a non-targetable version of Fah into the highly expressed Apolipoprotein A1 (Apoa1) locus, to protect the hepatocytes from further injury. A high-protein diet in these mice increased expansion of edited hepatocytes and corrected of about a quarter of all hepatocytes in the liver, and increased the expression of therapeutic transgene human factor IX (FIX) by five-fold. This increased expansion of targeted hepatocytes may expand the number of liver diseases targetable by gene therapy. Credit: Marco De Giorgi
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ONLINE COVER Transforming Lung Cancer. The cover illustrates a lung adenocarcinoma cell (pink) transitioning to an intermediate state (purple) that can then transdifferentiate into a lung squamous cell carcinoma cell (red) or small cell lung carcinoma cell (blue). This issue of Science Translational Medicine features a Focus article by Alvaro Quintanal-Villalonga, the winner of the 2024 AAAS Martin and Rose Wachtel Cancer Research Award, which is given each year to a young scientist who has made important contributions to the field of cancer research. Credit: Fathema Z. Uddin
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ONLINE COVER An Adjuvant Advance. The cover shows a mouse inguinal lymph node after vaccination with the BNT162b2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine adjuvanted with a lipid nanoparticle-encapsulated mRNA encoding interleukin (IL)–12p70. The lymph node was stained for naïve (yellow) and germinal center (green) B cells, T cells (magenta), and follicular dendritic cells (blue) to visualize the vaccine-elicited immune response. Immunity elicited by SARS-CoV-2 mRNA vaccines have been shown to wane over time, particularly in older individuals. To improve immune durability, Brook et al. adjuvanted the BNT162b2 SARS-CoV-2 vaccine with a mRNA encoding IL-12p70, which amplified vaccine responses even at lower vaccine doses. The authors also developed a strategy to limit expression of the mRNAs to muscle, potentially reducing systemic reactogenicity after vaccination. Together, these data show that mRNA vaccines, like their protein counterparts, benefit from adjuvantation. Credit: Brook et alMAC_Bench/Science Translational Medicine
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ONLINE COVER Covering 10 Years of Translation. The image shows a collection of Science Translational Medicine covers, one for each year of the journal's publication. To celebrate Science Translational Medicine's 10th anniversary and a decade of exciting translational research, we are launching with this issue a special Focus series "Science Transforming Medicine". Focus articles in this series will highlight key translational research advances in different fields achieved since the journal began publishing in October 2009. The first Focus article in this series by Zmora et al. discusses the rapid pace of advances in microbiome research and the challenges ahead for developing microbiota-based therapies. [CREDIT: SCIENCE TRANSLATIONAL MEDICINE]
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Trends in Genetics
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40_7
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Which of the following options best describe the cover image?
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This Special Issue of Trends in Genetics covers a range of themes related to organogenesis, from the formation of the central
nervous system to the evolution of the insect eye. The articles in this issue highlight
the commonalities of organ formation that are shared across species and kingdoms,
and provide insight on the mechanisms that underlie organogenesis, including regulation
by non-coding RNA and cell expansion driven by polyploidy. Cover image: iStock/kreatiw.
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The neuronal methylome is distinct from other cell types. While the classical form
of methylation at CG residues is present across all cell types, neurons are uniquely
enriched for methylation outside of this context at CA, CT, and CC (CH) residues.
The illustration on the cover highlights the differences in patterns of methylation,
with methylated CG sites represented as grey circles distributed throughout the body
and methylated CH sites specifically enriched within the brain. On pages 816–832,
Clemens and Gabel discuss the importance of CH methylation in the brain in connection
with MeCP2, a methylated-DNA binding protein, also enriched in neurons. They highlight
the dose-sensitive nature of these two components and their mechanistic roles in gene
regulation and neurodevelopmental diseases. Cover art: Richa Rathore.
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The neuronal composition that makes up our brains is relatively stable
from shortly after birth to adulthood. However, these post-mitotic neurons continue
to
undergo property changes throughout the lifespan. In this issue, Gabrielle Prince,
Molly
Reynolds, Verdion Martina, and HaoSheng Sun describe recent characterizations of the
functional and molecular changes that neurons undergo across postnatal development
and discuss cell-intrinsic versus cell-extrinsic mechanisms in the regulation of neuronal
maturation. Illustration by Dalton Patterson, Sharrell Greene, and Gabrielle Prince.
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In this special issue of Trends in Genetics, we turn the lens on ourselves. The articles
this month focus on human genetics, with topics ranging from resources and methods
to make the most of the explosion of sequencing data to evolutionary questions about
mutation rates and how selection acts through pregnancy.
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Nature Reviews Materials
|
10_1
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Tissue biomechanics provides essential biological information that is important for various biomedical applications, and conformable electronic devices are instrumental for decoding this information. The cover shows an artist’s impression of island-bridge structures, consisting of rigid functional "islands" connected by flexible "bridges", which allow devices to be stretched or bent without losing functionality. See Yoon H. et al.
Cover: David Johnston
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Metamaterials provide a platform to leverage optical signals for performing specific-purpose computational tasks with ultra-fast speeds. This Review surveys the basic principles, recent advances and promising future directions for wave-based-metamaterial analogue computing systems. See Zangeneh-Nejad et al.
Image: Romain Fleury. Cover design: Charlotte Gurr.
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Chalcogenide phase-change materials (PCMs) are leading candidates for non-volatile memory and neuro-inspired computing devices. This Review focuses on the crystallization mechanisms of PCMs as well as the design principles to achieve PCMs with high switching speeds and good data retention. See Zhang et al.
Image: Ider Ronneberger, Cover design: Lauren Robinson
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The field of molecular magnetism has expanded from the chemical design and study of single-molecule magnets and magnetic materials, to more physics- and nanotechnology-driven areas. In this Review, this change in focus is discussed and molecular magnetism in combination with either molecular spintronics, quantum technologies, metal—organic frameworks or 2D materials is outlined. See Eugenio Coronado
Cover Image: Eugenio Coronado, Universitat de Valencia
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ACS Applied Bio Materials
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2024_12
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Which of the following options best describe the cover image?
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A
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The antibacterial properties of nanosheet-shaped crystalline assemblies of enzymatically synthesized aminated cellulose oligomers (namely, surface-aminated synthetic nanocelluloses) and their synergy with a metal-chelating antibacterial agent, ethylenediaminetetraacetic acid, were demonstrated.
|
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The cover image depicts a supramolecular switching surface that can be easily switched between bactericidal and antifouling states by host−guest interaction. As the negatively charged macrocyclic host S6-corona[3]arene[3]pyridazine (S6-CAP) are incorporated to the bactericidal surface, the bactericidal ability of the surface is switched off, and the surface is transformed to an antifouling state. After being switched on by simply washing off much of S6-CAP, the bactericidal activity is even better than the original contact-killing surfaces. With this method, we can create a switchable contact-killing surface that may be helpful for tackling the problems of drug-resistance-induction and adhesion-to-invalidation.
|
MAC_Bench/ACS/Story/ACS Applied Bio Materials/2019_11.txt
|
ave_2
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2019_11.txt
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The cover image depicts the semiconducting oligomer amphiphiles (OPV-PEG)-based activatable nanoprobes for in vivo imaging of biothiols. OPV-PEG is composed of a hydrophobic semiconducting segment that serves as both the signal source and the sensing moiety for biothiols, and the hydrophilic poly(ethylene glycol) (PEG) side chains to provide the water-solubility. OPV-PEG can self-assemble with a near-infrared (NIR) photosensitizer to emit both NIR fluorescence and afterglow luminescence. In the presence of biothiols in living animals, the NIR fluorescence of this nanoprobe is turned on, but the afterglow signal remains the same, which permits precise tracking of the probe location while detecting biothiols.
|
MAC_Bench/ACS/Story/ACS Applied Bio Materials/2018_3.txt
|
clip
|
2018_3.txt
|
The cover image portrays an injectable neutrophilic attractant and antibacterial hydrogel applied to infected wounds. This hydrogel is made of κ-Carrageenan incorporated with octenidine dihydrochloride and chitosan-treated serum. Octenidine, an antiseptic agent, shows antibacterial activity by rupturing the bacterial membrane. Chitosan-treated serum induces migration of fibroblasts and neutrophils into the wounded area. Neutrophils further accelerate bacterial clearance. Fibroblasts facilitate tissue regeneration at the wounded site. This combinatorial effect helps in treating infectious wounds and facilitates the wound healing process.
|
MAC_Bench/ACS/Story/ACS Applied Bio Materials/2019_12.txt
|
vitg
|
2019_12.txt
|
train
|
Nature Reviews Physics
|
6_5
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/Nature Reviews Physics/6_5.png
|
A
|
The cover of this issue is based on ab initio predictions of superconducting critical temperatures. See Pellegrini & Sanna
Image: Adapted from Pellegrini, C. & Sanna, A. Nat. Rev. Phys. (2024) Cover design: Susanne Harris.
|
MAC_Bench/Nature/Story/Nature Reviews Physics/6_5.txt
|
groundtruth
|
6_5.txt
|
The cover of this issue is inspired by a Review on quantum programming languages. See Bettina Heim et al.
Cover design: Charlotte Gurr.
|
MAC_Bench/Nature/Story/Nature Reviews Physics/2_1.txt
|
vith
|
2_1.txt
|
The cover shows a tiled microscopy image of a monolayer MoS2 sample, contacted with metal contacts. See Wang & Chhowalla
Image: Yan Wang, University of Cambridge. Cover design: Charlotte Gurr.
|
MAC_Bench/Nature/Story/Nature Reviews Physics/4_11.txt
|
clip
|
4_11.txt
|
The cover of this issue shows a photograph of a spontaneous parametric down-conversion Type I beam and is inspired by a Review on imaging with quantum states of light. See Moreau et al.
Image: Paul-Antoine Moreau, University of Glasgow. Cover Design: Carl Conway
|
MAC_Bench/Nature/Story/Nature Reviews Physics/1_7.txt
|
vitg
|
1_7.txt
|
train
|
NATURE MATERIALS
|
24_1
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/NATURE MATERIALS/24_1.png
|
D
|
Electronically morphing microrobot
A kirigami metasheet microrobot shows electronically programmable shape morphing and movement.
See Liu et al.
Image: Zihe Liang and Qingkun Liu, Shanghai Jiao Tong University; Itai Cohen, Cornell University. Cover design: Alex Whitworth
|
MAC_Bench/Nature/Story/NATURE MATERIALS/24_2.txt
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clip
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24_2.txt
|
Nanoscale environments created by topological defects in liquid crystals can serve as a template for the self-assembly of molecular amphiphiles within the defects.
Article p106; News & Views p10
IMAGE: NICHOLAS ABBOTT GROUP
COVER DESIGN: DAVID SHAND
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MAC_Bench/Nature/Story/NATURE MATERIALS/15_12.txt
|
ave_2
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15_12.txt
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Complex element coupling expands materials capabilities
Increasing compositional complexity expands the space of manipulating materials properties, bringing both opportunities and challenges to design and processing.
See Xue et al. & Editorial
Image: background, Yuichiro Chino / Moment / Getty; structure, Hang Xue & Chong Yang, Xi’an Jiaotong University. Cover design: Lauren Heslop
|
MAC_Bench/Nature/Story/NATURE MATERIALS/22_9.txt
|
vith
|
22_9.txt
|
Electronically morphing microrobot
A kirigami metasheet microrobot shows electronically programmable shape morphing and movement.
See Liu et al.
Image: Zihe Liang and Qingkun Liu, Shanghai Jiao Tong University; Itai Cohen, Cornell University. Cover design: Alex Whitworth
|
MAC_Bench/Nature/Story/NATURE MATERIALS/24_1.txt
|
groundtruth
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24_1.txt
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train
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Trends in Biotechnology
|
42_5
|
Which of the following options best describe the cover image?
|
MAC_Bench/Cell/Cover/Trends in Biotechnology/42_5.png
|
D
|
On pages 448–458, Zahra Hamrang and colleagues review emerging trends and novel technologies
that offer a promising potential for accurately predicting and profiling protein aggregation
at various stages of biopharmaceutical product design. The cover image is from iStockPhoto
and design is by Paige Shaklee.
|
MAC_Bench/Cell/Story/Trends in Biotechnology/31_5.txt
|
vitg
|
31_5.txt
|
Trends in Biotechnology is celebrating its 30th year of publishing exciting reviews
in biotechnology. The coverimage shows microbes taking advantage of the occasion.
Cover image made by Julien Husson and coverdesigned by Paige Shaklee.
|
MAC_Bench/Cell/Story/Trends in Biotechnology/31_11.txt
|
clip
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31_11.txt
|
CRISPR/Cas and other genome editing approaches have quickly become centrally important
biotechnological techniques in synthetic biology. This month, we focus on emerging
aspects of genome editing ranging from generating high-value chemicals in prokaryotes
to designing synthetic gene circuits. In pages 535–547 of this issue, Jusiak, Cleto,
and colleagues discuss the applications of CRISPR to transcriptional regulation and
envision a paradigm of highly efficient transcription factor design using genome editing.
Cover image from Sara Cleto, Timothy Lu, and the Elsevier Webshop, and cover design
by Matthew Pavlovich.
|
MAC_Bench/Cell/Story/Trends in Biotechnology/34_7.txt
|
vith
|
34_7.txt
|
Systems and synthetic biology control 'knobs' can design and reprogram
bacterial phenotypes, illustrated as light bulbs. However, inherent genomic redundancies
and the presence of unknown factors make genome manipulation difficult and undermine
the performance of desired functionalities. In pages 1048–1063 of this issue, Kim
and
colleagues discuss integrative top-down and bottom-up genome reduction schemes.
These schemes make it possible to design 'optimal genomes' that are more amenable
to genetic reprogramming and can execute targeted functions in a more effective and
orthogonal fashion. Cover image from Kangsan Kim, Donghui Choe, and Byung-Kwan Cho.
|
MAC_Bench/Cell/Story/Trends in Biotechnology/42_5.txt
|
groundtruth
|
42_5.txt
|
val
|
ACS Chemical Neuroscience
|
2024_22
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2024_22.png
|
C
|
.
|
MAC_Bench/ACS/Story/ACS Chemical Neuroscience/2010_12.txt
|
vitg
|
2010_12.txt
|
10.1021/acschemneuro.0c00004
|
MAC_Bench/ACS/Story/ACS Chemical Neuroscience/2020_21.txt
|
clip
|
2020_21.txt
|
Unraveling the interplay between dopamine, carbon monoxide, and heme oxygenase: suggesting an axis that likely plays important roles in neuromodulation and cognition.
|
MAC_Bench/ACS/Story/ACS Chemical Neuroscience/2024_22.txt
|
groundtruth
|
2024_22.txt
|
The mechanisms accounting for the formation of pores by amyloid peptides are revealed by unbiased all-atom simulations. Peptides adsorb, aggregate into β-sheets, and form pores spontaneously at the surface of lipid bilayers. Four peptides differing in the distribution of polar and nonpolar residues along the sequence are investigated.
|
MAC_Bench/ACS/Story/ACS Chemical Neuroscience/2024_7.txt
|
vith
|
2024_7.txt
|
test
|
Nature Reviews Physics
|
6_3
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/Nature Reviews Physics/6_3.png
|
C
|
The cover of this issue illustrates the physics and sustainability theme launching this month. See Editorial
Cover design: Susanne Harris.
|
MAC_Bench/Nature/Story/Nature Reviews Physics/5_10.txt
|
vitg
|
5_10.txt
|
The cover of this issue shows the Large Hadron Collider at CERN. In a Focus on future particle accelerators we explore the proposed projects and underlying technologies that would make the next big particle collider possible. See Editorial
Image: The Large Hadron Collider, CERN.
|
MAC_Bench/Nature/Story/Nature Reviews Physics/1_9.txt
|
clip
|
1_9.txt
|
The cover of this issue is based on the CERN accelerator complex. See the Editorial.
Image: S.Harris/Springer Nature Limited.
|
MAC_Bench/Nature/Story/Nature Reviews Physics/6_3.txt
|
groundtruth
|
6_3.txt
|
The cover of this issue shows a network of similar products for the Egyptian economy. See César Hidalgo
Image: César Hidalgo, ANITI, University of Toulouse, France. Cover design: Charlotte Gurr.
|
MAC_Bench/Nature/Story/Nature Reviews Physics/3_11.txt
|
vith
|
3_11.txt
|
train
|
Journal of the American Chemical Society
|
2024_34
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_34.png
|
D
|
Through massive molecular dynamics simulations, it was found that the fluorine domain endows fluorinated ionic liquids ultrahigh solubility of nitrogen. Meanwhile, a theoretical model of fluorine densification energy was also constructed to predict the abnormal solubility of nitrogen based on the microscopic structure of fluorinated ionic liquids. View the article.
|
MAC_Bench/ACS/Story/Journal of the American Chemical Society/2024_15.txt
|
clip
|
2024_15.txt
|
The surprising solvation environment of methylglyoxal at the air/liquid water interface suggests new chemical pathways for hydration that are more feasible in the absence of atmospheric acid catalyzers.
|
MAC_Bench/ACS/Story/Journal of the American Chemical Society/2020_39.txt
|
vith
|
2020_39.txt
|
A flow platform has been developed for the rapid assembly of polypeptides through native chemical ligation coupled with a novel photodesulfurization transformation. This technology was used to prepare the clinically approved HIV therapeutic enfuvirtide and the diagnostic agent somatorelin 2 orders of magnitude faster than traditional batch methods. See Payne and co-workers. DOI: 10.1021/jacs.8b03115. View the article.
|
MAC_Bench/ACS/Story/Journal of the American Chemical Society/2018_23.txt
|
vitg
|
2018_23.txt
|
Tuning acid/base electrochemistry via hydrophobicity and electric fields. View the article.
|
MAC_Bench/ACS/Story/Journal of the American Chemical Society/2024_34.txt
|
groundtruth
|
2024_34.txt
|
train
|
Nature Reviews Neurology
|
20_10
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/Nature Reviews Neurology/20_10.png
|
B
|
Microglia in the tumour microenvironment, inspired by the Review on p243.
Cover design: Philip Patenall.
|
MAC_Bench/Nature/Story/Nature Reviews Neurology/17_9.txt
|
vitg
|
17_9.txt
|
Seizures in Alzheimer disease, inspired by the Review on p162.
Cover design: Philip Patenall
|
MAC_Bench/Nature/Story/Nature Reviews Neurology/20_10.txt
|
groundtruth
|
20_10.txt
|
Modelling Alzheimer disease in a dish, inspired by the Review on p25.
Cover design: Philip Patenall.
|
MAC_Bench/Nature/Story/Nature Reviews Neurology/18_12.txt
|
clip
|
18_12.txt
|
Synaptic degeneration in Alzheimer disease, inspired by the Review on p19.
Cover design: Philip Patenall
|
MAC_Bench/Nature/Story/Nature Reviews Neurology/19_12.txt
|
ave_0
|
19_12.txt
|
test
|
Molecular Pharmaceutics
|
2024_10
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2024_10.png
|
B
|
Berberine chloride and four aliphatic dicarboxylic acids form novel cocrystals with higher melting point, improved dissolution, and lower hygroscopicity. The melting points and intrinsic dissolution rates of these cocrystals exhibit an
|
MAC_Bench/ACS/Story/Molecular Pharmaceutics/2021_9.txt
|
clip
|
2021_9.txt
|
This image represents a painting of a monolayer of lymphatic endothelial cells stained with VE-cadherin and DAPI containing fluorescent nanoparticles. The original painting was created by Shae Shortt. View the article.
|
MAC_Bench/ACS/Story/Molecular Pharmaceutics/2024_10.txt
|
groundtruth
|
2024_10.txt
|
γ
|
MAC_Bench/ACS/Story/Molecular Pharmaceutics/2020_7.txt
|
vitg
|
2020_7.txt
|
Highlighting the cutting-edge, multidisciplinary, translational research in pharmaceutical sciences originating from researchers across Asia, the American Chemical Society journal Molecular Pharmaceutics is pleased to present a Virtual Special Issue titled "Advances in Molecular Pharmaceutical Research from Asia." Within the VSI, the Guest Editors have collected a wide range of articles that spotlights the wide range of research in the region. An accompanying editorial by the Guest Editor Team provides context and commentary to accompany the collection.
|
MAC_Bench/ACS/Story/Molecular Pharmaceutics/2023_5.txt
|
vith
|
2023_5.txt
|
train
|
Nature Physics
|
20_2
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/Nature Physics/20_2.png
|
C
|
When networks get real
Combining concepts from knot theory and statistical mechanics leads to a method for distinguishing between physical networks with identical wiring but different layouts.
See Barabási et al.
IMAGE: Alice Grishchenko. COVER DESIGN: Allen Beattie
|
MAC_Bench/Nature/Story/Nature Physics/17_11.txt
|
clip
|
17_11.txt
|
Charge on the bouncing barrier
In our understanding of planetary formation, it is still unclear how millimetre-sized dust grains grow into centimetre-sized aggregates. Microgravity experiments now show that electrical charging of the grains leads to the formation of larger clumps.
See Steinpilz et al.
Image: Tobias Steinpilz. Cover Design: Lauren Heslop
|
MAC_Bench/Nature/Story/Nature Physics/16_11.txt
|
vith
|
16_11.txt
|
Cellular energy budget
How cells manage the internal energetic budget to drive mechanical and chemical dynamics is still an open question. Sheng Chen and collaborators show that the allocation of energy depends on how far the cell is from thermodynamic equilibrium.
See Sheng Chen et al.
Image: William Bement (University of Wisconsin-Madison), Sheng Chen (Yale University), Michael Murrell (Yale University). Cover design: Laoise Mac Gabhann
|
MAC_Bench/Nature/Story/Nature Physics/20_2.txt
|
groundtruth
|
20_2.txt
|
The formation of a shell
Molluscs are capable of assembling layers of material in the shells around them with exquisite control. Synchrotron-based nanotomographic imaging of the structural evolution of this layer formation has now prompted a model that draws analogy with topological defect dynamics in liquid crystals
Article → N&V
IMAGE: Igor Zlotnikov. COVER DESIGN: Allen Beattie.
|
MAC_Bench/Nature/Story/Nature Physics/17_10.txt
|
vitg
|
17_10.txt
|
train
|
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
|
22_1
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/22_1.png
|
A
|
Diet and intestinal stem cells, inspired by the Review on p23
Cover design: Neil Smith
|
MAC_Bench/Nature/Story/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/22_1.txt
|
groundtruth
|
22_1.txt
|
Future of the gut microbiome, inspired by the Viewpoint on p830
Cover design: Laura Marshall
|
MAC_Bench/Nature/Story/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_1.txt
|
clip
|
21_1.txt
|
Diet and intestinal stem cells, inspired by the Review on p23
Cover design: Neil Smith
|
MAC_Bench/Nature/Story/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/22_2.txt
|
vitg
|
22_2.txt
|
Gut cell atlas, inspired by the Roadmap on p597.
Cover design: Laura Marshall
|
MAC_Bench/Nature/Story/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/20_4.txt
|
ave_3
|
20_4.txt
|
train
|
Organometallics
|
2025_4
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/Organometallics/2025_4.png
|
B
|
Modifying the steric properties of ligands enables tuning the reactivity of organometallic complexes. Although various methods have been developed to quantify the steric parameters of mononuclear complexes, these had not been validated for dinuclear complexes. The cover shows two copper atoms window shopping for dinucleating ligands. In the window, they see three 1,8-naphthyridine-based ligands with different substituents. Each carries price tags with calculated steric parameters using our validated methodology. This enables the copper atoms to find the right fit for their needs. We gratefully acknowledge Dr. Emily Monkcom for designing the cover art.
|
MAC_Bench/ACS/Story/Organometallics/2023_24.txt
|
ave_2
|
2023_24.txt
|
s reactivity trend in activating C(spn)–X bonds mirrors that of a palladium catalyst. Reactivity increases by two distinct mechanisms: i) as the C(spn)–X bond becomes progressively weaker from X = F to Cl to Br to I, resulting in a more facile bond rupture, and ii) as the steric shielding at the pertinent carbon atom diminishes from C(sp3)–X to C(sp2)–X to C(sp)–X, leading to less steric clash and therefore a more stabilizing catalyst–substrate interaction.
|
MAC_Bench/ACS/Story/Organometallics/2025_4.txt
|
groundtruth
|
2025_4.txt
|
The future is shining bright for organometallics. This special issue shines light on photo-active organometallic complexes and their applications as photoredox catalysts.
|
MAC_Bench/ACS/Story/Organometallics/2024_9.txt
|
clip
|
2024_9.txt
|
What is the application? Consider how organometallic expertise can be extended to determine and realize new translational research opportunities. The diverse applications of organometallic chemistry featured in this Special Issue continue to inspire creative directions and novel approaches within the discipline.
|
MAC_Bench/ACS/Story/Organometallics/2024_5.txt
|
ave_1
|
2024_5.txt
|
train
|
Nature Machine Intelligence
|
6_7
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/Nature Machine Intelligence/6_7.png
|
D
|
Learning from human decision making
Artificial intelligence and machine learning systems may surpass human performance on a variety of tasks, but they may also mimic or amplify human errors or biases. This issue of Nature Machine Intelligence features a Perspective describing decades of research by psychologists on the development and prevention of errors and biases in human judgment and decision making. The authors provide connections between the psychology and machine learning literatures, and offer guideposts for the development and improvement of machine learning algorithms.
See Alexander S. Rich and Todd M. Gureckis
Image: Exdez/DigitalVision Vectors/Getty images. Cover design: Karen Moore
|
MAC_Bench/Nature/Story/Nature Machine Intelligence/1_9.txt
|
clip
|
1_9.txt
|
Intelligent collaboration within reach
As robots are becoming skilled at performing complex tasks, the next step is to enable useful and safe interactions with humans. To effectively collaborate with and assist us, robots need to be able to understand human actions and intent. This issue of Nature Machine Intelligence features an Article describing a game theoretic approach for adaptive human–robot collaboration, as well as a Comment that considers how several trends in robotics and AI research are merging for a fresh take on collaborative robotics.
See Li et al., News & Views by Drnach & Ting and Comment by Goldberg
Image: Robert Adrian Hillman/Alamy Stock Vector (hands); GoMixer/Alamy Stock Vector (machine). Cover Design: Karen Moore.
|
MAC_Bench/Nature/Story/Nature Machine Intelligence/1_12.txt
|
vitg
|
1_12.txt
|
Neural architecture search for computational genomics
Applying deep learning models requires the tuning of network architectures for optimum performance, which can require substantial machine learning expertise. In this issue, Zijun Zhang et al. present a fully automated framework, AMBER, to design and apply convolutional neural networks for genomic sequences using neural architecture search. In an accompanying News & Views, Yi Zhang, Yang Liu and X. Shirley Liu discuss the AMBER technique and its potential to improve deep learning models in genomics.
See Zhang et al. and Zhang, Liu and Liu
Image: Simons Foundation. Cover design: Lauren Heslop.
|
MAC_Bench/Nature/Story/Nature Machine Intelligence/3_8.txt
|
ave_2
|
3_8.txt
|
Self-motion estimation with neuromorphic resonator networks
Estimating position and movement relative to objects with vision is a challenging computational problem in robotics. Renner et al. propose a neuromorphic solution, aiming at low-power, brain-inspired machine vision for mobile robots. In this approach, event-based neuromorphic vision sensors convert luminance changes during movement into spikes, illustrated in the cover image, with colour representing time. A neural architecture then analyses scene structure and the sensor’s pose, building a working memory of the environment.
See Renner et al. and Renner et al.
Image: Alpha Renner and Lazar Supic. Cover design: Amie Fernandez
|
MAC_Bench/Nature/Story/Nature Machine Intelligence/6_7.txt
|
groundtruth
|
6_7.txt
|
train
|
Trends in Biotechnology
|
42_6
|
Which of the following options best describe the cover image?
|
MAC_Bench/Cell/Cover/Trends in Biotechnology/42_6.png
|
A
|
Miniaturized in vitro bone models, known as "mini-bones," have emerged as
powerful tools for studying physiology, disease mechanisms, and regenerative processes
of
bone, and for designing new bone-related therapies. In pages 910–928 of this issue,
Fois
and colleagues discuss how the mini-bones require small amounts of cells and materials,
are compatible with high-throughput production and screening methods and high-content
imaging, and offer good bone mimicry. This image highlights the concept of mini-bones
that
are made from cellular and matrix-mimicking building blocks in a bottom-up manner.
Cover
image designed by Daniela Velasco Lozano.
|
MAC_Bench/Cell/Story/Trends in Biotechnology/42_6.txt
|
groundtruth
|
42_6.txt
|
LEGO® bricks are toys for kids that can be used to assemble mindblowing
creations. In pages 1073–1087 of this issue, Boulter et al. discuss an alternative
use of LEGO® bricks to design and assemble open-access scientific tools and systems
for biotechnology and other fields of science. The LEGO® brick road depicted on the
cover, as inspired by the yellow brick road from the 1939 film The Wizard of Oz, is a
metaphor for a sinuous road that leads towards a reachable, yet distant, world of
open
science. The road is sprinkled with LEGO® creations that symbolize life science and
concepts addressed in the article. Cover image designed by Julien Colombelli. LEGO®
is a trademark of The LEGO Group, which did not sponsor, authorize or endorse this
artwork.
|
MAC_Bench/Cell/Story/Trends in Biotechnology/40_5.txt
|
vith
|
40_5.txt
|
Trends in Biotechnology is celebrating its 30th year of publishing exciting reviews
in biotechnology. The coverimage shows microbes taking advantage of the occasion.
Cover image made by Julien Husson and coverdesigned by Paige Shaklee.
|
MAC_Bench/Cell/Story/Trends in Biotechnology/31_11.txt
|
clip
|
31_11.txt
|
Trends in Biotechnology is celebrating its 30th year of publishing exciting reviews
in biotechnology. The coverimage shows microbes taking advantage of the occasion.
Cover image made by Julien Husson and coverdesigned by Paige Shaklee.
|
MAC_Bench/Cell/Story/Trends in Biotechnology/31_10.txt
|
ave_1
|
31_10.txt
|
train
|
ACS Sustainable Chemistry & Engineering
|
2025_6
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/ACS Sustainable Chemistry & Engineering/2025_6.png
|
C
|
Lower right: Catalytic hydrogenation-esterification, which yields products favorable for subsequent upgrading, will benefit the high-grade utilization of sustainable biomass energy. (See J. Chen, Q. Cai, L. Lu, F. Leng, and S. Wang; DOI: 10.1021/acssuschemeng.6b02366.)
|
MAC_Bench/ACS/Story/ACS Sustainable Chemistry & Engineering/2017_9.txt
|
clip
|
2017_9.txt
|
Graphics from this issue of ACS Sustainable Chem. Eng.
|
MAC_Bench/ACS/Story/ACS Sustainable Chemistry & Engineering/2017_12.txt
|
vitg
|
2017_12.txt
|
The CO2 tree highlights the breadth of chemical compounds currently accessible from CO2 to illustrate its potential to serve as a carbon source for the future.
|
MAC_Bench/ACS/Story/ACS Sustainable Chemistry & Engineering/2025_6.txt
|
groundtruth
|
2025_6.txt
|
The cover art illustrates the innovative method of synthesizing spherical lignin-based 3D porous carbons (LSPCs). These ecofriendly spheres depict high surface areas and customizable micro/mesopores. With their impressive performance in supercapacitors and sodium-ion batteries, these materials significantly advance in creating ecofriendly energy storage solutions.
|
MAC_Bench/ACS/Story/ACS Sustainable Chemistry & Engineering/2024_47.txt
|
vith
|
2024_47.txt
|
train
|
ACS Chemical Neuroscience
|
2024_5
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2024_5.png
|
B
|
A gold-star-coated aluminum substrate-based SERS immunoassay platform for the selective detection of blood-based biomarkers Aβ40, Aβ42, p-Tau, and t-Tau of Alzheimer’s disease (AD). SERS spectral data augmented by the machine learning technique yielded high sensitivity of the order of an attomolar concentration of the biomarkers and successfully differentiated between controls and patients with mild cognitive impairment and AD. The image was generated with the assistance of ChatGPT, powered by OpenAI.
|
MAC_Bench/ACS/Story/ACS Chemical Neuroscience/2024_1.txt
|
ave_2
|
2024_1.txt
|
Interpreting immune cell behavior and signaling is critical to understanding Alzheimer's neuroinflammation. Preventing neurodegeneration is the goal of reorienting attention from Aβ synthesis to immune-mediated clearance. Successfully addressing obstacles such as negative immune reactions might result in notable progress in the field of immunotherapy by enhancing the accuracy of treatment.
|
MAC_Bench/ACS/Story/ACS Chemical Neuroscience/2024_5.txt
|
groundtruth
|
2024_5.txt
|
10.1021/acschemneuro.0c00004
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Discovery of the peptide therapeutics targeting amyloid formation in neurodegenerative diseases, using the synergistic combination of yeast display and phage display techniques.
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BDJ Student
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BDJ Student - King's College London takeover
Welcome to this very special edition of BDJ Student!
In 2025, three dental schools will be taking over each of our issues. In this January edition, I'm delighted to introduce the King's College London takeover, packed full of interesting and insightful articles from one of the country's leading dental schools
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Volume 28 | Issue 3
How can we integrate oral health with global health? The cover feature in this edition's BDJ Student asks - and answers - that very question
Cover illustration by Cat Sims
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Vol 31 | Issue 2
In this spring issue of BDJ Student, our lead feature takes a closer look at four dental professionals who have taken their clinical knowledge and applied it outside the practice
Cover illustration by Cat Sims
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Volume 28 | Issue 1
In this issue we hear from new BDA President Russ Ladwa, detail the career options for dentists in the UK and delve into oral medicine conditions you need to know about
Cover illustration by Cat Sims
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Science Robotics
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ONLINE COVER Biohybrid Robots—Controlling Robotic Hand Movement with Muscle Tissue. Biohybrid robots provide the advantage of combining muscle tissue derived from cells as well as synthetic components. These muscle tissues can be controlled to generate contractile forces necessary to provide linear movement of joints. Ren et al. have developed a multifingered robotic hand that was powered by bundles of muscle tissue. The muscles were connected to tendons and ultimately to the individual fingers, which could be controlled independently to generate flexion when exposed to electrical stimulation. This month’s cover is an image of the biohybrid robotic hand showing the fingers in flexion. Credit: : Shoji Takeuchi research group/University of Tokyo
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ONLINE COVER A Model of Oneself. Robots, like humans and animals, require self-models to be able to anticipate and plan future actions. Chen et al. developed a method that enables a robot arm to model its morphology and kinematics using an approach based on query-driven visual self-modeling. This month’s cover is a multiple-exposure image of a self-modeled robot arm touching a small red sphere while avoiding a large red cube. Credit: Columbia Engineering
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ONLINE COVER Soft Robotics Across Scales. Extensive research, from materials engineering to whole systems, is expanding the boundaries of robotics to create stretchy, flexible, touch-feedback electronics; advanced microelectromechanical systems; and shape-morphing and self-propelling devices. Umrao et al. designed Ti3C2Tx electrodes ionically cross-linked with PEDOT:PSS for high-performance air-working ionic soft actuators. The resulting actuators tolerated high bending strains, responded rapidly to electric signals, and remained durable after hours of use. They were used as artificial muscles in kinetic structures, such as this butterfly (mass of 310 grams). [CREDIT: Umrao et alMAC_Bench/Science Robotics]
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ONLINE COVER Piano Forte. Human hands are complex and agile, but most robotic end effectors are simple and bulky. Hughes et al. used 3D-printing technology to create robotic devices that mimic human hands, with stiff skeletal frames surrounded by flexible "ligaments" controlling movement at joints. They varied ligament stiffness and the force applied to strike a piano key; the resulting data led to models predicting the range of motion for a specific set of conditions. The validity of the approach and the design was demonstrated with a system able to play excerpts of three different pieces of music, representing a range of styles, in a manner close to that of a human. [CREDIT: J. HUGHES & N. CHORNAY/UNIVERSITY OF CAMBRIDGE]
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Developmental Cell
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59_22
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B
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On the cover: This image shows a developing human forebrain organoid at day 60, which
has a “tree-like” structure. Neural progenitor cells are marked by SOX2 (green), lysosomes
are marked by LAMP1 (white), and nuclei are marked by DAPI (blue). During the development
of embryonic neocortex, there are abundant endolysosomes in the neural progenitor
cells near the ventricle. Using our analogy to a tree, they function like roots, absorbing
nutrients from the cerebrospinal fluid in the ventricle to maintain the proliferative
capacity of the neural progenitor cells. As differentiated intermediate progenitor
cells and neurons migrate upward along the “trunk,” the cortical plate is formed.
To learn more about how lysosomal dynamics regulate neurogenesis, see Zou et al. Image credit: Yuqing Lv and Wenzheng Zou.
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On the cover: Confocal microscopy image of a mouse embryonic pancreatic explant showing
pancreatic epithelial branches (green) and acinar progenitor cells (purple). At this
stage, pancreatic duct cells are marked by Prox1 (green) and form secondary branches,
which end with acinar structures positive for Integrin alpha6 (purple). To learn more
about how embryonic pancreatic tissue undergoes branching morphogenesis, see Darrigrand et al. Image credit: Jean-Francois Darrigrand.
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On the cover: Cell intercalation generates directed forces that elongate the vertebrate
body axis during early development. In this image, a heatmap quantifying tissue-scale
pushing forces is superimposed over an image of polarized, intercalating cells. For
more about how Arvcf Catenin is required specifically for the generation of robust
pushing forces by these cells, see Huebner and Weng on page 1119. Image created from
heatmap made by Shinuo Weng and microscopy of Asako Shindo.
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On the cover: Developmental Cell publishes papers representing a full range of cell biology and development, from
molecular mechanism to organismal pathophysiology. The spiraling elements depicted
on the cover of this month's tenth anniversary issue suggest a continuum of relationships
amongst these intertwined disciplines. Cover image created by Kate Mahan and Yvonne
Blanco.
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Trends in Biochemical Sciences
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49_1
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In this issue of Trends in Biochemical Sciences, women scientists are the primary authors of the Opinion and Review articles. From
Anna Marabotti and colleagues, “Standardizing macromolecular structure files: further
efforts are needed”; from Ilaria Elia et al, “The metabolic cross-talk between cancer
and T cells”; from Tatiana G. Kutateladze and Nitika Gaurav, “Non-histone binding
functions of PHD fingers”; from Jing-Dong Ja. Han, “LncRNAs: the missing link to senescence
nuclear architecture”; from Joanna Rorbach et al, “Insights into mitoribosomal biogenesis
from the recent structural studies”; and from Susan Daniel and colleagues “Membrane
protein synthesis: no cells required”. Cover image: GettyImages/DrAfter123.
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Small heat shock proteins (sHsps) protect the proteome against
deleterious effects of protein unfolding, catching non-native proteins before they
aggregate and precipitate. On pages 1063–1078 in this issue, Johannes Buchner
and colleagues describe the structural and functional principles of sHsp oligomers
and what makes them versatile and adaptive for trapping a large range of non-native
proteins. Cover art, colors inspired by “The Catcher in the Rye”, by Carsten Peters.
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On The Cover: Molecular dynamics (MD) simulations can be used to visualize fluctuations of biological
macromolecules at high resolution, though are often only represented as static figures
in published literature. On pages 902–913 of this issue of Trends in Biochemical Sciences, Drs. Peter Hildebrand, Alexander Rose, and Johanna Tiemann highlight how advances
in browser technology may enable scientists to interactively share and visualize simulations
on the web. Cover image source: iStock/AlisaRut.
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In this issue of Trends in Biochemical Sciences on pages 39–51, Olarte
et al. describe two pathways, the CYTOLD and ERTOLD pathways, for directing protein
to the surface of lipid droplets (LDs). The cover is an artistic depiction of lipid
droplets
budding from the endoplasmic reticulum (ER), a membrane network where lipids are
synthesized, into the cytoplasm. The budding lipid droplets are filled with neutral
lipids, such as triacylglycerols, and bounded by a phospholipid monolayer. During
LD
formation, specific proteins containing amphipathic helices or hydrophobic, membraneembedded
motifs use the CYTOLD and ERTOLD pathways, respectively, to localize
and accumulate on the LD surface. Cover image designed by Maria-Jesus Olarte and
created by scientific illustrator Allison Bruce (www.akbruce.com).
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Trendsin Neurosciences
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47_4
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Which of the following options best describe the cover image?
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On The Cover: In this issue of Trends in Neurosciences, Jay Schulkin and Peter Sterling review recent evidence for allostasis, the efficient, anticipatory regulation of physiology. The brain predicts what will
be needed and, via myriad descending control mechanisms, including hypothalamus and
cerebral cortex, directs the neuroendocrine system and autonomic nervous system (see
cover) to deliver what is needed—just enough, just in time. This system minimizes
costly errors that need correction by feedback, i.e., homeostasis. Image credit: https://en.wikipedia.org/wiki/Autonomic_nervous_system, license type CC BY 3.0.
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Synucleinopathies are characterized by neuronal loss accompanied by
α-synuclein accumulation in the brain. While research conventionally focused on brain
pathology, there is growing evidence for peripheral alterations in synucleinopathies,
including in erythrocytes, which are rich in α-synuclein. Erythrocyte-derived extracellular
vesicles, containing pathological α-synuclein species, can traverse the blood–brain
barrier under certain conditions, as well as the gastrointestinal tract, where α-synuclein
and gut microbiota interact extensively. In this issue of Trends in Neurosciences, Ying
Yang and colleagues explore the accumulating evidence of erythrocyte involvement in
synucleinopathies, as well as their potential in disease pathogenesis and diagnosis.
Image credits: Science Photo Library – SCIEPRO / Getty Images.
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Pyramidal neurons with active dendritic properties are found ubiquitously across the
neocortex. On pages 141–151, Matthew Larkum presents the hypothesis that both the
cellular properties and architecture of the cortex are tightly coupled, suggesting
a powerful operating principle of the cortex. The cover image shows layer 5 neocortical
pyramidal cells from different regions of the cortex coding for orientation, color
and form (of a tiger) while receiving feedback input (context) to the dendrites. An
artist's impression of a dendritic spike is shown in one of the pyramidal cells. Cover
design: Thomas Splettstoesser. Credit for the cloud image: Chris Schwarz (Shutterstock.com).
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Normal development and functioning of the nervous system is critically dependent upon
interaction with the immune system. Recent research at the interface of neuroscience
and immunology has revealed the ways in which reciprocal neuroimmune interactions
are important for many brain-behavior relationships. This Special Issue of Trends
in Neurosciences is devoted to cutting edge research at the intersection of the nervous
and immune systems. Topics covered include the molecular logic of the blood-brain
barrier, the role of myeloid cells in traumatic brain injury, Alzheimer’s disease,
and depression, and similarities between psychological and immunological memory formation.
Cover image: iStockphoto.
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Trends in Plant Science
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29_11
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C
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Individual plant and enemy species (or populations) are reciprocally interacting in
a way that shapes their traits and evolution. This concept of specificity in plant–herbivore
and plant–pathogen interactions is central to this special issue of Trends in Plant
Science. Why is it that most herbivores and pathogens attack a minute fraction of
the plants or even plant organs available to them? How do plants manage to defend
against diverse enemies? Why are plant enemies specialized at all, given that specialization
seems to simply limit the number of available hosts? Are most current plant–enemy
interactions the result of a coevolutionary history, and can these be manipulated
to protect our agricultural crops from pest insects and disease and our ecosystems
from invasive species? In this issue we combine perspectives of the plant with that
of its enemies, in order to address these questions and focus on the traits that allow
for successful plant defense versus successful exploitation of plant tissues. Cover
design by Alejandro de León.
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Enormous societal challenges, such as feeding and providing energy for a growing population
in a dramatically changing climate, necessitate technological advances in plant science.
On pages 303–310 Seung Y. Rhee and colleagues propose that, complementary to the efforts
towards understanding the cellular diversity in human brain and immune systems, a
Plant Cell Atlas would accelerate discovery in plant science and help solve imminent
societal problems. The Plant Cell Atlas would map molecular machineries to cellular
and subcellular domains, follow their dynamic movements, and describe their interactions.
Cover design by Susanne C. Brink. Image credit: Arabidopsis thaliana embryoes by Fernán Federici and Jim Haseloff.
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Precise communication between the pollen tube and the synergid
cells within the ovule is essential to coordinate pollen tube rupture, followed by
delivery and reception of the sperm cells. Alice Baillie and colleagues provide insight
into the complicated interaction between the receptor-like kinases involved, and their
co-receptors and ligands. The cover image represents the detail of an arabidopsis
flower,
with male pollen tubes travelling down the transmitting tract towards the ovule micropyles
where the tubes interact with the female synergid cells. Image credit: Jen Sloan.
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Two papers by Christoph-Martin Geilfus and colleagues and Muzammil Hussain, Dominique
Van Der Straeten and colleagues discuss the recent breakthrough discovery that stressed
plants emit various informative ultrasonic sound signals, which can be categorized
according to plant species, stress type, and stress severity. This unlocks a new path
into research of plant—environment interactions with multiple possibilities for future
applications. Image credit: Daniela Leitner (design) and Christoph-Martin Geilfus
(concept).
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Nature Reviews Materials
|
9_9
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This month, we celebrate the fifth anniversary of Nature Reviews Materials. In our editorial, we look back over this time and contemplate the future. See Editorial.
Cover: Charlotte Gurr
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CO2 electroreduction aims to decarbonize by converting CO2 and clean energy into chemicals. To have an impact, this technology should be scaled up into the gigatonne conversion range, which involves challenges related to resource and material scalability bottlenecks. The cover shows an artistic representation of the implementation of CO2 electrolysis to scale and its materials needs. See Belsa B. et al.
Cover image: Francisco Pelayo García de Arquer. Cover design: David Johnston.
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Microscale robots' unique active motion enables their precise navigation in different aqueous biological or environmental media. The image shows an artist’s impression of microrobots using photocatalysis to degrade chemical and biological warfare agents for environmental remediation. See Chen C. et al
Cover image: David Johnston.
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Crystallization of soft materials often follows pathways not envisioned in classical theories of crystallization, instead passing through disordered, amorphous, or dense liquid precursors. The recent emergence of techniques to probe these pathways with minimal damage has led to a growing knowledge about these pathways. The image illustrates crystallization via a dense liquid precursor as the free energy of the system decreases, as well as the in-situ observation of this process. See Du J.S. et al
Cover image: Cortland Johnson. Cover design: David Johnston
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Current Biology
|
34_10
|
Which of the following options best describe the cover image?
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On the cover: A large number of gray reef sharks fight over a grouper. Pristine marine
locations are rare and usually host a large number of sharks, raising the question
of how such a high predator density can be supported by local food. In this issue,
Mourier et al. (pages 2011–2016) report extremely high shark biomass in pristine Fakarava
pass, French Polynesia. This study presents a new mechanism in which food subsidies
directly come to predators in the form of spawning aggregations, allowing them to
stay inside the reef pass. Also see the Dispatch by Simpfendorfer and Heupel (pages
R708–R710). Photo credit: Laurent Ballesta.
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On the cover: White shark (Carcharodon carcharias) swimming in the clear waters around Guadalupe Island (Mexico). In this issue, Wagner et al. use genome-wide sequencing to show global white shark populations are divided into
three distinct genetic lineages: Atlantic/Mediterranean, North Pacific, and Indo-Pacific.
These lineages diverged 100,000–200,000 years ago and rarely interbreed. Image credit:
Getty/Cultura Exclusive/Rodrigo Friscione.
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On the cover: With this issue, Current Biologycompletes its twentieth year. Since its origins as a journal publishing “dispatches
from the front lines of biology,” Current Biologyhas continuously expanded in terms of both paper formats and breadth of subjects covered.
We hope the journal will continue to evolve and look forward to the exciting biology
that the next twenty years may bring for us and our readers. For more, see the editorial
by current Editor Geoffrey North and founding Editor Peter Newmark (pages R1049–R1051).
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On the cover: In this issue, Skomal et al. (pages 1019–1022) use satellite archival
tags and a novel geolocation technique to demonstrate that the world's second largest
fish, the basking shark, makes ocean basin-scale movements in the western Atlantic
over a much broader geographic range than previously thought. The authors found that
basking sharks migrate seasonally from temperate shelf waters off the coast of New
England to deep subtropical and tropical waters of the Bahamas and the Caribbean Sea
to the coast of South America and into the Southern Hemisphere. These results significantly
alter the known distribution and habitat of this species and highlight the need for
global conservation efforts throughout its range. Photograph © Nick Caloyianis | www.nickcaloyianis.com.
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Trends in Cancer
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10_9
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Which of the following options best describe the cover image?
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Variations in cancer incidence fuel the debate on the relative contributions of intrinsic
vs extrinsic factors. On pages 409–415 in this issue, Thomas et al. add an extra piece to the puzzle by exploring the concept of evolutionary ecology
in oncogenesis, and discuss how an organ ecosystem and its contribution to Darwinian
fitness determines vulnerability to cancer. Cover design by Eric Pélatan.
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Barcoding technologies are enabling the quantification of heterogeneous populations
as well as changes in phenotypic states of cancer cells. In this issue, Howland and
Brock discuss various barcoding technologies that are providing unique opportunities
to understand tumor evolution in the context of selective pressures, such as tissue
and environmental interactions or drug treatments. The cover depicts sailboats (cancer
cells) that can be identified by their unique sails (barcodes) during a voyage (tumor
evolution). Cover image modified with permission from gettyimages/diane555.
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Fast-paced advances in single-cell sequencing technologies allow unprecedent ways
to probe tumor development, evolution, and response to therapies. On pages 13–19,
González-Silva et al. discuss the opportunities and roadblocks to use these technologies to unravel the
complexities of tumor heterogeneity, and translation into patient care. Cover design
by Kip Lyall.
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In the evolving era of cancer immunotherapy, combination strategies
are becoming ever more effective in overcoming challenges associated with PD-1
monotherapy. In this issue, Hashimoto et al. discuss the potential of PD-1/IL-2
combination regimen in enhancing anti-cancer therapy efficacy through shaping the
differentiation trajectory of CD8 T cells, thereby impacting their exhaustion program.
The cover depicts an effector CD8 T cell (upper right), generated by PD-1 blockade
and
IL-2 therapy, effectively finding and killing malignant cells (lower left). The cover
image
was created by Mie Yoshimura.
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Acta Pharmacologica Sinica
|
45_6
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Cover Credit: DZ2002, a reversible inhibitor of type III S-adenosyl-L-homocysteine hydrolase, attenuates TNF-α-induced NF-κB signaling by suppressing the degradation and phosphorylation of IκB, along with NF-κB p65 phosphorylation and nuclear translocation. Additionally, DZ2002 inhibits the activation of molecules in the STAT3-PI3K-Akt pathway, suppressing the secretion of inflammatory cytokines and pro-angiogenic factors. These findings strongly support DZ2002's promising therapeutic potential for dry eye disease (DED).
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Cover Credit: In this cover article, Zhou et al. constructed a novel mechanistic quantitative systems pharmacology model describing the underlying pathophysiological processes of HER2+BC, from ligand-receptor binding to downstream signaling and finally to tumor growth, while incorporating the distinct modalities and mechanisms of various state-of-the-art therapeutics. A large variety of in vitro and in vivo experimental data was used during model calibration and validation, achieving a quantitative and accurate description of cellular signaling, time-response, dose-response, and tumor growth kinetics. In a high-throughput manner, this multiscale QSP model platform enabled researchers to probe into the efficacy of different therapeutic strategies at the preclinical level, generate new hypothesis regarding best treatment combinations to overcome resistance, and suggested important directions for future translational drug research and model-informed drug development. Doi:10.1038/s41401-024-01232-9. See the article in pages 1287–1304
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Cover Credit: Suppressive tumor immune microenvironment (TIME) contributes to tumor progression and immunotherapy failure. Noninvasive radiofrequency radiation (RFR) exposure reshapes TIME into an antitumor phenotype by altering the transcription profile of tumor-infiltrating immune cells in pulmonary metastatic melanoma, resulting in enhanced cytotoxicity signature of tumor-infiltrating CD8+ T and NK cell subsets. Doi:10.1038/s41401-024-01260-5. See the article in pages 1492–1505
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Cover Credit: Reduction-activatable PROTAC prodrug nanoparticles for tumor-targeted protein degradation and anticancer therapy. The reduction-activatable PROTAC prodrug nanoparticles (NPs) were engineered by self-assembly of the PROTAC-conjugated amphiphilic diblock copolymer and further functionalized with a CRGDK ligand. The resulting PROTAC prodrug NPs can specifically target tumor cells and be efficiently internalized by recognizing neuropilin-1 (NRP-1), which is overexpressed on the surface of tumor cells. Remarkably, the PROTAC prodrug NPs efficiently degraded the protein targets BRD4 and CDK9 for inhibiting tumor growth in an mouse model of MDA-MB-231 triple-negative breast cancer. More importantly, the PROTAC prodrug NP can serve as a platform for co-delivering chemotherapeutic agents (e.g., doxorubicin, DOX) to perform combinatory cancer therapy. (Doi: 10.1038/s41401-024-01266-z). See the article in pages 1740–1751.
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Trends in Cancer
|
10_5
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|
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We invite readers to explore the newest addition to the Trends collection Trends in Cancer, which aims to cover a range of topics in cancer research including the latest developments
in basic, translational and clinical sciences, pharma R&D, technology, ethics, and
policy. The inaugural issue of Trends in Cancer tackles the big questions in cancer research today by leading researchers in the
field. The cover depicts an image of a crab or cancer in Latin. The name cancer comes from early observations by Greek physician Hippocrates
of finger-like projections emanating from the diseased mass, calling to mind the shape
of a crab (carcinos in Greek, and later, cancer in Latin). The concept was developed by Danielle Loughlin and Kip Lyall, and the
image was designed by Kip Lyall.
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This Special Issue on Physical Sciences in Oncology celebrates recent advances and new scientific frontiers in a rising field that is
bringing back the application of physical principles to biology, and fostering a wide-angle
cross-disciplinary perspective on cancer. Cover design by Imdat As.
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The cover image depicts a masked face harbouring an intricately woven
web of connections, signifying the virtual global network that helps cultivate a feeling
of ‘togetherness’ in the backdrop of a pandemic threatening to keep us apart. The
theme, ‘Apart, Together’ symbolises the many experiences of members of the scientific
community, who continue to bravely serve and survive a deadly pandemic. This
statement resonates strongly with many, including the Trends team, managing their own
commitments and responsibilities from disparate geographical locations, while being
part of a collective. For our Editorial describing this important idea, please turn
to pages
1047–1049. Cover Image Credit: Phillip Krzeminski.
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Traditional approaches to understand mental health in cancer survivors
often involve the classification of psychopathology into discrete disorders. However,
this approach has faced mounting criticism. In this issue, Haywood et al. propose that
the hierarchical dimensional approach (HiTOP model) diminishes stigma, considers
the individual holistically, and offers a more reliable clinical assessment. The cover
depicts the artist’s mother, a cancer survivor who struggled with mental health post-treatment.
The setting is dark, but in white, an outline of her brain emerges, and from
there, an array of neurons which symbolizes the mind. The image of the neurons
slowly unravels to demonstrate the complexity of the mind as well as the unique
confusion and pain that cancer survivors struggle with. Cover design by Caroline Cha,
VI4 Artist-in-Residence Program.
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MAC_Bench/Cell/Story/Trends in Cancer/10_5.txt
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Trends in Biochemical Sciences
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49_7
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In this issue of Trends in Biochemical Sciences on pages 39–51, Olarte
et al. describe two pathways, the CYTOLD and ERTOLD pathways, for directing protein
to the surface of lipid droplets (LDs). The cover is an artistic depiction of lipid
droplets
budding from the endoplasmic reticulum (ER), a membrane network where lipids are
synthesized, into the cytoplasm. The budding lipid droplets are filled with neutral
lipids, such as triacylglycerols, and bounded by a phospholipid monolayer. During
LD
formation, specific proteins containing amphipathic helices or hydrophobic, membraneembedded
motifs use the CYTOLD and ERTOLD pathways, respectively, to localize
and accumulate on the LD surface. Cover image designed by Maria-Jesus Olarte and
created by scientific illustrator Allison Bruce (www.akbruce.com).
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On The Cover: Molecular dynamics (MD) simulations can be used to visualize fluctuations of biological
macromolecules at high resolution, though are often only represented as static figures
in published literature. On pages 902–913 of this issue of Trends in Biochemical Sciences, Drs. Peter Hildebrand, Alexander Rose, and Johanna Tiemann highlight how advances
in browser technology may enable scientists to interactively share and visualize simulations
on the web. Cover image source: iStock/AlisaRut.
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In this issue of Trends in Biochemical Sciences, women scientists are the primary authors of the Opinion and Review articles. From
Anna Marabotti and colleagues, “Standardizing macromolecular structure files: further
efforts are needed”; from Ilaria Elia et al, “The metabolic cross-talk between cancer
and T cells”; from Tatiana G. Kutateladze and Nitika Gaurav, “Non-histone binding
functions of PHD fingers”; from Jing-Dong Ja. Han, “LncRNAs: the missing link to senescence
nuclear architecture”; from Joanna Rorbach et al, “Insights into mitoribosomal biogenesis
from the recent structural studies”; and from Susan Daniel and colleagues “Membrane
protein synthesis: no cells required”. Cover image: GettyImages/DrAfter123.
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Osmotic stress conditions cause changes in the physicochemical
properties of the cellular environment, including macromolecular crowding. Recent
progress has shed light on how cells sense such environmental perturbations (e.g.
temperature, pH, and crowding). On pages 480–493 in this issue, Meneses-Reyes et al.
discuss how intrinsically disordered regions in proteins can sense macromolecular
crowding in plants and provide a tool guide for tracking macromolecular crowding in
living cells. Cover image by Cesar Cuevas-Velazquez, inspired by Mexican seed art.
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Science Signaling
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2007_379
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Which of the following options best describe the cover image?
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B
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ONLINE COVER This week features a Research Article that describes a calcium-accumulating region in Orai channels that is important for ion flux at low concentrations of extracellular calcium. The image shows a snapshot of a molecular dynamics simulation of this region of the channel. The yellow balls are calcium ions. [Image: Vasilina Zayats/Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, and Faculty of Sciences, University of South Bohemia, Czech Republic]
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COVER This week features a Perspective on nonconventional functions of the phagocytic NADPH oxidase (NOX2). The image depicts a neutrophil extracellular trap (NET), formation of which depends on reactive oxygen species generated through NOX2 activity. [Image: Volker Brinkmann, Max-Planck Institute for Infection Biology, 10117 Berlin, Germany]
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groundtruth
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ONLINE COVER This week, Santi et al. report that cancer-associated fibroblasts release matrix-bound vesicles that transfer proteins to endothelial cells, resulting in enhanced monocyte adhesion to endothelial cells. The image shows a three-dimensional reconstruction of endothelial cells co-cultured with cancer-associated fibroblasts. The yellow, green, red, and purple structures are vesicular structures containing proteins transferred to the endothelial cells; the blue oblong structures are nuclei; and the white lattice shows actin filaments. Image: Santi et alMAC_Bench/Science Signaling
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ONLINE COVER This week features a Research Article that shows how neuronal activity is coordinated by a network formed by gap junction–linked astrocytes. The image shows bursting activity in a hippocampal slice from a wild-type mouse. [Image: Elena Dossi (Center for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Paris, France)]
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Nature Physics
|
20_3
|
Which of the following options best describe the cover image?
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B
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Braided anyons
An interferometer device is used to detect the quantum-mechanical phase that is gained when two anyons are braided around each other. The fractional value of the phase proves that these quasiparticles are neither bosons nor fermions.
Manfra, Article
IMAGE: James Nakamura and Michael Manfra, Purdue University. COVER DESIGN: Alex Wing.
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Electronic motion up close
Charge density waves are wave-like patterns in a material’s electron density that can behave collectively. Shaoxiang Sheng et al. show a direct real-space observation of these collective dynamics at the atomic scale in the transition metal dichalcogenide 2H-NbSe2. Their technique utilizes a terahertz pulse that is enhanced at the tip of a scanning tunnelling microscope to excite oscillations of the charge density wave that vary in magnitude and frequency on the scale of individual atomic impurities. Measuring the current through the tip reveals overlapping phase excitations originating from randomly distributed atomic defects in the surface and creates a spatially structured response of the charge density wave.
See Shaoxiang Sheng et al.
Image: Kurt Lichtenberg, University of Stuttgart. Cover design: Laoise Mac Gabhann
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MAC_Bench/Nature/Story/Nature Physics/20_3.txt
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Odd viscosity
A chiral fluid comprising spinning colloidal magnets exhibits macroscopic dynamics reminiscent of the free surface flows of Newtonian fluids, together with unique features suggestive of Hall—or odd—viscosity.
See Irvine et al.
Image: Vishal Soni, Ephraim Bililign, Sofia Magkiriadou, University of Chicago. Cover Design: David Shand
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MAC_Bench/Nature/Story/Nature Physics/15_2.txt
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Controlled turbulence
Turbulence is generated using vortex rings as building blocks in a quiescent environment.
See Matsuzawa et al. and Research Briefing
Image: Takumi Matsuzawa, IrvineLab, University of Chicago. Cover Design: Amie Fernandez.
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Nature Reviews Endocrinology
|
20_9
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Which of the following options best describe the cover image?
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D
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Our April issue includes articles on circadian rhythms and exercise, innervation of adipose tissue, enteroendocrine cells and gut hormones and the function of motilin.
Pancreatic islet image supplied by Shih-Jung Peng and Shiue-Cheng Tang at Department of Medical Science, National Tsing Hua University, Taiwan. Cover design: Jennie Vallis.
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MAC_Bench/Nature/Story/Nature Reviews Endocrinology/15_9.txt
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The ageing thyroid, inspired by the Review on p5.
Cover design: Jennie Vallis
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clip
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20_12.txt
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COVER: Modelling endometrial diseases, inspired by the Review on p727.
Cover design: Jennie Vallis.
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18_1.txt
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How to manage iatrogenic adrenal insufficiency, inspired by the Review on p209.
Cover design: Jennie Vallis
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MAC_Bench/Nature/Story/Nature Reviews Endocrinology/20_9.txt
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groundtruth
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Cell Systems
|
15_7
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Which of the following options best describe the cover image?
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A
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On the cover: Illustration showing simulations of tumor growth arranged as the two
strands of a DNA helix, shattered by the emblematic double strand break induced by
PARP inhibitors. The simulations (strands) compare two adaptive strategies: as the
tumor responds and regrows under treatment (blue lines), doses are either modulated
or skipped (shading and bars, with some artistic liberties). In this issue of Cell Systems, Strobl et al. integrate real-time microscopy and mathematical modeling to investigate whether adaptive
therapy, which dynamically tailors treatment to the tumor dynamics, could help to
reduce cumulative PARP inhibitor use to reduce toxicity. Image credit: Kit Gallagher
and the authors.
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MAC_Bench/Cell/Story/Cell Systems/15_7.txt
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groundtruth
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15_7.txt
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On the cover: Cell Systems turns one. This issue features a Focus on RECOMB (Li et al., 21–34; Sefer et al.,
35–42; El-Kebir et al., 43–53; Simmons et al., 54–61; Dao et al., 62–70) and our new
Tool article format (Durand et al., 95–98 and 99–101; Liepe et al., 102–107) and badge
(Ritchie et al., 71–82). They represent one aspect of our broader ambition to bridge
research fields (see our Editorial, 1–2), including between experimental and computational
biologists (see Voices, 7–11). Scan the QR code for a special anniversary message
from the editors.
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On the cover: Cell Systems is doing its part to keep the wheels of the scientific endeavor turning during the
COVID-19 pandemic. In this issue, Editor-in-Chief Quincey Justman (307) describes
our approach. Image credit: denisgo, Getty Images.
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MAC_Bench/Cell/Story/Cell Systems/10_3.txt
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On the cover: The two-dimensional representation of protein sequence space learned
by a recurrent geometric network, a deep learning model that predicts protein structure
directly from sequence. Contours correspond to different protein folds as they are
organized inside the model's internal representation. In this issue of Cell Systems, Mohammed AlQuraishi (292–301) introduces and benchmarks this approach to machine
learning protein structure.
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MAC_Bench/Cell/Story/Cell Systems/8_3.txt
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ave_1
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train
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Nature Nanotechnology
|
19_5
|
Which of the following options best describe the cover image?
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MAC_Bench/Nature/Cover/Nature Nanotechnology/19_5.png
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A
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Pinpoint doping for polymers
The cover shows an atomic force microscopy image of nanoscale doped plastic polymers achieved through precise electrochemical ion implantation.
See Lanyi Xiang et al.
Image: Chong-an Di, Institute of Chemistry, Chinese Academy of Sciences. Cover design: Debbie Maizels
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MAC_Bench/Nature/Story/Nature Nanotechnology/19_5.txt
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groundtruth
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Superlubricity occurs when friction between two sliding surfaces almost vanishes. This phenomenon has been observed so far only for small specimens that are a few micrometres wide at most. Yingying Zhang and colleagues have now observed superlubricity between centimetre-long concentric carbon nanotubes (schematically shown on the cover), which was made possible by a synthesis method that allows the production of pure carbon nanotubes that are several centimetres long.
Letter p912; News & Views p893
IMAGE: FEI WEI
COVER DESIGN: ALEX WING
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MAC_Bench/Nature/Story/Nature Nanotechnology/8_1.txt
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clip
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8_1.txt
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Lasing from bulk nanocrystals
The image depicts surface-emitting lasers consisting of a bulk nanocrystal layer covered by a 2D photonic crystal grating.
See Geiregat
Image: Ivo Tanghe, Ghent University. Cover design: Valentina Monaco
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MAC_Bench/Nature/Story/Nature Nanotechnology/18_1.txt
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Plasmonics with nanocrystals.
Cover design by Karen Moore.
Article by Tao et al .
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MAC_Bench/Nature/Story/Nature Nanotechnology/2_6.txt
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Trends in Genetics
|
40_9
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Which of the following options best describe the cover image?
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MAC_Bench/Cell/Cover/Trends in Genetics/40_9.png
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D
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Barbara McClintock once said “With the tools and the knowledge, I could turn a developing
snail's egg into an elephant. It is not so much a matter of chemicals because snails
and elephants do not differ that much; it is a matter of timing the action of genes.”
This Focus issue of Trends in Genetics delves into studies aimed at understanding
gene regulation from a network perspective and looks at how regulatory mechanisms
emerge and evolve over time. The goal of this work is to develop a deeper understanding
of the gene circuits that govern all cellular processes. Cover image from iStock/aleksandarvelasevic.
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MAC_Bench/Cell/Story/Trends in Genetics/30_8.txt
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vith
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30_8.txt
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In this special issue of Trends in Genetics, we turn the lens on ourselves. The articles
this month focus on human genetics, with topics ranging from resources and methods
to make the most of the explosion of sequencing data to evolutionary questions about
mutation rates and how selection acts through pregnancy.
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MAC_Bench/Cell/Story/Trends in Genetics/29_4.txt
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vitg
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29_4.txt
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This Special Issue of Trends in Genetics covers a range of themes related to organogenesis, from the formation of the central
nervous system to the evolution of the insect eye. The articles in this issue highlight
the commonalities of organ formation that are shared across species and kingdoms,
and provide insight on the mechanisms that underlie organogenesis, including regulation
by non-coding RNA and cell expansion driven by polyploidy. Cover image: iStock/kreatiw.
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MAC_Bench/Cell/Story/Trends in Genetics/31_7.txt
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In this issue: Genomic resources and profound ecological knowledge
make Littorina snails useful models for speciation studies. Ecotypes and closely related
species adapted to different rocky-shore environments form hybrid zones where
reproductive isolation can be investigated. In this issue, Kerstin Johannesson and
co-authors
show that evolution of reproductive isolation can take different paths and is best
analysed using multi-dimensional frameworks. Contrary to expectations they suggest
that ecotype formation rarely leads to new species and that chromosomal inversions
play a greater role in local adaptation than in completion of reproductive isolation.
Illustration by Patrik Larsson.
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MAC_Bench/Cell/Story/Trends in Genetics/40_9.txt
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groundtruth
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Journal of Chemical Education
|
2021_10
|
Which of the following options best describe the cover image?
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MAC_Bench/ACS/Cover/Journal of Chemical Education/2021_10.png
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D
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Evoking affective responses from students studying chemistry may heighten their curiosity and further engage their interest in the subject, motivating them to delve deeper. In "Integrating Aesthetics Education into Chemistry Education: Students Perceive, Appreciate, Explore, and Create the Beauty of Chemistry in Scientific Photography Activity" (DOI: 10.1021/acs.jchemed.9b00857), Yizhou Ling, Jiamin Xiang, Kai Chen, Junyao Zhang, and Hongyan Ren describe microscale lab activities in which students photograph precipitation reactions using a smartphone with magnification. Students observe changes in color, shape, texture, and opacity in various reactions of metal salts with sodium hydroxide solutions, including with cobalt chloride (pictured on the cover), ferrous sulfate, and copper sulfate. Using a wider lens to perceive the complexity and beauty of chemical reactions coupled with an aesthetic approach to wonder why and how these changes occur can stimulate experimental inquiry, affective response, and creative outcomes, including high-quality scientific photography.
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Modern chemistry programs must include the skills and techniques that enable their graduates to perform experiments safely. In response to a call for papers, scientists and educators from around the world have contributed articles to the Journal of Chemical Education's Special Issue on Chemical Safety Education: Methods, Culture, and Green Chemistry. The articles in the issue are broadly distributed among topics covering resources, green chemistry, safety culture, and pedagogy. This issue is a resource for ideas and discussion to encourage "a new way to look at safety", with a focus on assessing hazards, minimizing risk, and valuing a strong chemical safety culture. (Cover image courtesy of Jane E. Wissinger.)
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The cover images are from one of the many videos available at the JCE Chemical Education Xchange Web site (ChemEd X, http://www.jce.divched.org/). The Journal of Chemical Education’spartner Web site aims to foster sharing of digital resources, information, and ideas among chemical educators. (Images from Chemistry Comes Alive!, JCE Software.)
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With resurgent lunar exploration and expansion of the commercial space sector, serious scholarship, planning, and resources have focused on extracting and using lunar materials to sustain activity in space. In "Lunar Resource Harvesting and Manufacturing: Rich Content for the Chemistry Classroom" (DOI: 10.1021/acs.jchemed.0c01381), Joshua D. Kittle, Michael W. Duff, and John M. Engesser use this engaging, interdisciplinary, space-oriented topic to excite and inspire chemistry students, while reinforcing general chemistry concepts. (Image of moon courtesy of NASA. Image from NASA Moon Mineralogy Mapper showing water detected at high latitudes courtesy of ISRO/NASA/JPL-Caltech/Brown Univ./USGS.)
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Nature Mental Health
|
2_5
|
Which of the following options best describe the cover image?
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MAC_Bench/Nature/Cover/Nature Mental Health/2_5.png
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D
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Climate mental health
The February cover is a moody depiction of climate mental health. Intended to invoke the idea of the interplay among Gaia (the spirit of Earth), nature and humanity, the blue tones also reference the Connecting Climate Minds project. As a means for placing mental health prominently in climate agendas, this initiative is a catalyst for invigorating the broader climate mental health field.
See our Editorial for more on the emerging field of climate mental health
Image: Rebeka Ryvola/Climate Cares Centre. Cover design: Debbie Maizels
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Earth, brain and health
Our October issue features a Comment announcing the Earth, Brain and Health Commission that has been convened with Nature Mental Health. By applying innovative cutting-edge technology, such as remote-sensing satellite data, with other sociodemographic and neuroimaging data, the commission seeks to shape new ways to identify biomarkers to help understand the environmental impact on mental health. Our cover is a nod to capturing the topography of green and blue spaces, as well as associations with brain and mental health, using satellite imagery.
Read more in the Comment from Schumann et al
Cover design: Marina Spence
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Mental health awareness
Each May, campaigns take place that are designed to draw awareness to mental health, to reduce stigma and to champion inclusivity. This month’s issue cover features a green ribbon — the international symbol that is associated with observing Mental Health Awareness Month. Not only is green the theme color of the Nature Mental Health journal, but the May cover is festooned with the mental health awareness ribbon, florals and greenery to evoke the imagery of vitality, growth, new beginnings and hope.
See our Editorial for more on the need to bring together advocacy and research to promote mental health awareness.
Cover design: Marina Spence.
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Countries and culture — mental health in context
Our August issue cover highlights how crucial our connections with countries and culture are and how they can meaningfully shape our mental health. In a sense, they are influences imprinted on brains and minds. From ancient philosophers and theologians to modern mental health researchers, country and culture have long been considered forces that affect our development and self-expression, our interpretations of feelings, and when and how we seek support or treatment for mental health conditions.
Read more in our Editorial about the importance of cultural context of mental health
Image: Jorg Greuel / Getty Images Plus. Cover design: Marina Spence
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MAC_Bench/Nature/Story/Nature Mental Health/2_5.txt
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groundtruth
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2_5.txt
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val
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Cell Reports Physical Science
|
5_4
|
Which of the following options best describe the cover image?
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MAC_Bench/Cell/Cover/Cell Reports Physical Science/5_4.png
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B
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On the cover: A visual celebration of Cell Reports Physical Science’s fifth anniversary, featuring all of our covers from Volume 1, Issue 1 to December
2024’s Volume 5, Issue 12. We’d like to thank Cell Press’s own Philip Krzeminski for
his help in creating this beautiful cover.
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MAC_Bench/Cell/Story/Cell Reports Physical Science/6_2.txt
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6_2.txt
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On the cover: The cover of this month’s issue of Cell Reports Physical Science summarizes the research of Li et al. on the preparation of multiscale hydrogels. The background represents a hydrogel’s
macroporous structure, which provides space for cells. The hydrogel (upper left) affects
mesenchymal stem-cell fate with local stiffness-enhancing structures (lower left)
and promotes bone regeneration (bottom right). This research has promising applications,
such as the possibility to be used as a 3D printing ink (upper right). The cover was
produced by Zhibao Xiao.
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MAC_Bench/Cell/Story/Cell Reports Physical Science/5_4.txt
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groundtruth
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5_4.txt
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On the cover: A visual celebration of Cell Reports Physical Science’s fifth anniversary, featuring all of our covers from Volume 1, Issue 1 to December
2024’s Volume 5, Issue 12. We’d like to thank Cell Press’s own Philip Krzeminski for
his help in creating this beautiful cover.
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MAC_Bench/Cell/Story/Cell Reports Physical Science/6_1.txt
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6_1.txt
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On the Cover: We celebrate our first issue with this eye-catching cover, designed
by the Cell Press creative team, representing our first “drop” of papers and signifying
the birth of a new journal and our expansion into the fundamental and applied physical
sciences.
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MAC_Bench/Cell/Story/Cell Reports Physical Science/1_12.txt
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Cancer Cell
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42_12
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MAC_Bench/Cell/Cover/Cancer Cell/42_12.png
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C
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On the cover: To holistically describe and comprehensively characterize cancer cells
and the surrounding tumor microenvironment, Bagaev et al. (pp. 845–865) analyzed transcriptomes
of over 10,000 cancer patients. This led to the identification of four distinct subtypes
of tumor microenvironment that are conserved across 20 different cancers. These four
subtypes, depicted in the cover, are strongly associated with prognosis and response
to immunotherapy.
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On the cover: Cancers sharing the same clinical diagnosis often harbor striking differences
at the molecular level. Such is the case for diffuse large B cell lymphoma (DLBCL).
A careful examination of different DLBCL molecular subsets reveals distinct metabolic
signatures. Depicted here is a close-up of an “OxPhos” cancer cell with pink mitochondria
visible below the plasma membrane. Callouts in gray highlight the integrated approach
used to reveal differences in carbon utilization, mitochondrial proteome, fatty acid
oxidation, and glutathione levels in this DLBCL subtype. See Caro et al., pp. 547–560.
Cover credit: Benjamin Szlyk and Illana Stanley.
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On the cover: Routy et al. review the microbiota research in the context of melanoma. The cover image demonstrates
the interplay between melanoma cancer cells and microbiota visually. An intricate
network of lines creates connections that symbolize the link between intestinal bacteria
and melanoma, highlighting the recent research included in the content, visually showcasing
the intricate relationship between the two. Image credit: Simon Rohlen, known as KEF!.
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MAC_Bench/Cell/Story/Cancer Cell/42_12.txt
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groundtruth
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On the cover: From Dangaj and Coukos et al. (pp. 885–900), cold tumors (ice floe side)
are characterized by low chemokine CCL5 expression and are immune desert. By contrast,
hot tumors (tropical side) express high levels of CCL5 and CXCL9, which cooperate
to recruit tumor-reactive T cells rendering the tumor microenvironment immunologically
fertile.
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NATURE MEDICINE
|
31_1
|
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MAC_Bench/Nature/Cover/NATURE MEDICINE/31_1.png
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A
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30th anniversary issue: the Future of Medicine
As Nature Medicine turns 30 years old, we will, throughout 2025, be looking at the future of medicine. In this first issue, we turn our attention to next-generation drug discovery.
Image and cover design: Alex Whitworth
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In 2004, Nature Medicine enters its tenth year of publication, continuing our mission to serve the biomedical research community as the venue for top-flight primary research articles, news and perspectives. The cover image commemorates our anniversary year with a collage of covers spanning our publication history. (Graphic by Lewis Long)
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This month Nature Medicine features a collection of articles focusing on regenerative medicine (pp 814880). Cover image: "My Life as a Hill" by Pamela Goode
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Medicine in the digital age
As Nature Medicine celebrates its 25th anniversary, we bring our readers a special Focus on Digital Medicine that highlights the new technologies transforming medicine and healthcare, as well as the related regulatory challenges ahead.
See Focus
Image credit: Peter Crowther. Cover design: Erin Dewalt
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Structure
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On the cover: Synaptotagmin-1 C2A and C2B domains bind to model lipid bilayers mimicking
the synaptic plasma membrane (C2B) and the synaptic vesicle membrane (C2A). A native
mass spectrum of Synaptotagmin-1 binding to DOPS at different stoichiometries is shown
below the plasma membrane plane. Bender et al. combined native mass spectrometry and protein-lipid binding assays with molecular
dynamics simulations to investigate the lipid preferences of the two Synaptotagmin-1
C2 domains. Image credit: Julian Bender.
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On the cover: In this special issue, we celebrate Structure’s 30th anniversary with a collection of reviews that highlight recent developments
in different areas of structural biology. We asked structural biologists what to expect
for the next decade in our Voices article. Cover image drawn by Julie Sung (scientific illustrator at Cell Press).
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On the cover: The image shows a rendering of the structure of the Haliangium ochraceum bacterial microcompartment shell, the cryo-electron microscopy structure of which
Greber et al. (pp. 749–763) present in a paper in this issue of Structure. The shell is composed of different types of BMC proteins, which are shown in different
colors in the depiction. For one type, different conformational states, correlated
across the shell surface, can be discerned in the cryo-EM maps.
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On the cover: In this issue, Huo et al. (pp. 1270–1279) combined X-ray crystallography
and electron microscopy to get the complete high-resolution open structure of group
II chaperonin from Acidianus tengchongensis strain S5 and elucidated the detailed
conformational changes from open to closed state. The cover shows two electron microscopy
(EM) maps positioned at the corner, with wall and floor covered in an image of the
projection-matching figure of single particle analysis. Crystal structures of group
II chaperonins subunits are fitted into the negative-stained EM map (yellow, close
state) and the cryoEM map (green, open state), respectively. The conformational changes
of domain rotation and subunit movement from open to closed state are depicted by
the intermediate conformational states of subunits from green, cyan, blue, magenta,
and red to yellow.
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Science Immunology
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ONLINE COVER Sugarcoated Vaccine. This month's cover illustration depicts the trimeric pre-fusion (pre-F) protein of respiratory syncytial virus (RSV) found in an engineered nanoparticle vaccine construct. Swanson et al. describe the synthesis and preclinical testing of an RSV vaccine candidate consisting of eight of these pre-F spikes attached to a ferritin core. The magenta-colored branched glycans engineered onto the protein surface shield poorly neutralizing epitopes on pre-F, allowing antibody responses to focus instead on the known neutralizing epitopes indicated by red patches. [CREDIT: K. SWANSON ET ALMAC_Bench/Science IMMUNOLOGY]
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ONLINE COVER Turning Anti–PD-1 on Its Head. This month's cover illustration is a 3D rendition of pembrolizumab, one of several therapeutic monoclonal antibodies against human PD-1 being used for cancer immunotherapy. Based on results with a new conditional allele of the Pdcd1 gene in mice, Strauss et al. report that PD-1 expression on both myeloid and T cells is relevant to the immune stimulatory effects of anti–PD-1. A Focus commentary by Rudd discusses the findings of Strauss et al. The illustration was created with NGL Viewer using x-ray crystallography data deposited in the RCSB Protein Data Bank. [CREDIT: PDB 5DK3]
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ONLINE COVER Promoting Tolerance. Depicted here is a type 1 regulatory T (TR1) cell (left) interacting with a dendritic cell (top right, dark purple) and an interleukin-27 (IL-27)–secreting macrophage (bottom right, light purple). Zhang et al. report that IL-27–driven commitment of T cells to the TR1 cell lineage limits graft-versus-host disease after bone marrow transplantation. [CREDIT: MADELEINE FLYNN, GRAPHIC SUPPORT OFFICER, QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE AND GARVIN GRULLÓN, AAAS]
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ONLINE COVER IgE Plasma Cells Are Cut from a Different Cloth. Immunoglobulin E–producing plasma cells (IgE PCs) are key players in allergic reactions and are an attractive target for the treatment of allergic diseases. A deeper understanding of IgE PC phenotypic and transcriptional profiles is needed, however. Vecchione et al. characterized IgE PCs from mice exposed to house dust mite allergen. IgE PCs were transcriptionally and phenotypically different from PCs producing other immunoglobulin isotypes, with increased endoplasmic reticulum stress due to higher levels of antibody production. IgE PCs in the lung-draining lymph node (dLN) and bone marrow (BM) showed distinct transcriptional profiles: The relatively short-lived IgE dLN PCs expressed genes indicative of recent class switching, whereas BM PCs were enriched for genes involved in survival and BM homing. This month’s cover illustration depicts plasma cells secreting a profusion of allergy-driving IgE antibodies. Credit: Noelle Burgess/Science Immunology
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NATURE REVIEWS DRUG DISCOVERY
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Targeting neutrophils, inspired by the Review on p253.
Cover design: Susanne Harris.
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Immune targets for antidepressants, inspired by the Review on p224.
Cover design: S. Harris
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N-of-1 therapies, inspired by the Review on p40.
Cover design: S. Harris
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Deuterium in drug discovery, inspired by the Review onp562.
Cover design: S. Harris
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NATURE REVIEWS MICROBIOLOGY
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Alternatives for treating antibiotic-resistant pathogens, inspired by the Review on p262.
Cover design: Philip Patenall.
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Machine learning for microbiologists, inspired by the Review on p191.
Cover design: Philip Patenall.
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Bacterial biofilms, inspired by the Focus issue.
Cover design: Philip Patenall
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Celebrating 20 years of Nature Reviews Microbiology.
Cover design: Neil Smith.
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Science Robotics
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ONLINE COVER Special Issue on Robots in the Wild. Robots have been successfully deployed in a wide range of domains–including land, sea, air, and space–for a variety of applications such as search and rescue, oceanography, wildlife surveys, and space exploration. In this issue, Zhou et al. have developed a trajectory planner for swarms of micro drones that can be implemented using only an onboard computer. Their planner computes trajectories based on limited information from the drone's onboard sensors to enable collision-free flight in cluttered environments in the wild. This month's cover is a photo illustration of a swarm of micro-drones flying through a forest (see also the Focus by Soria). Credit: Zhou et al./Zhejiang University
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ONLINE COVER Special Issue on Autonomy and AI in Robotics. A team of legged robots can efficiently explore unstructured terrains with task-level autonomy. Arm et al. report on a robot team comprising a “scout” that can identify potential scientific targets in an environment, a “hybrid” that collects data from the targets, and a “scientist” that performs in-depth scientific analysis of the targets. The robot team could efficiently map terrain mimicking planetary environments, identify resource-enriched areas, and scientifically analyze targets of interest. This month’s cover is an image of a team of legged robots exploring a field of boulders. Credit: Arm et alMAC_Bench/Science Robotics
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ONLINE COVER From the Tip Leveraging the flexibility that is possible when using soft materials, Hawkes et al. used pneumatics to extend the tip of a robot over an extended distance. They inflated chambers on only one side of the robot to make it turn. An onboard camera connected to a feedback loop allowed the robot to track toward a distant light source. [CREDIT: LINDA A. CICERO/STANFORD NEWS SERVICE]
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ONLINE COVER Snake-Like Robot—A Robot for Autonomous Navigation and Exploration of Icy Terrain. Vaquero et al. report on a snake-like robot, Exobiology Extant Life Surveyor (EELS), that was developed to autonomously explore icy moons such as Enceladus. EELS has a perception head containing sensors and cameras for detection of its surroundings, as well as screw-like segments that generate forward and backward motion horizontally on icy surfaces and vertically within ice vents. The robot was capable of autonomous motion planning and risk awareness. This month’s cover is an image of EELS being tested on Athabasca Glacier in Alberta, Canada. Credit: Courtesy of NASA/JPL-Caltech
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Journal of Medicinal Chemistry
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Light activation to inhibit prolyl hydroxylase 2, subsequently stabilizing hypoxia-inducible factor and promoting expression of the target gene. (Zhang, X.; et al. J. Med. Chem. 2019, 62, DOI: 10.1021/acs.jmedchem.9b00688)
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Flygare, J. A.; Beresini, M.; Budha, N.; Chan, H.; Chan, I. T.; Cheeti, S.; Cohen, F.; Deshayes, K.; Doerner, K.; Eckhardt, S. G.; Elliott, L. O.; Feng, B.; Franklin, M. C.; Reisner, S. F.; Gazzard, L.; Halladay, J.; Hymowitz, S. G.; La, H.; LoRusso, P.; Maurer, B.; Murray, L.; Plise, E.; Quan, C.; Stephan, J.-P.; Young, S. G.; Tom, J.; Tsui, V.; Um, J.; Varfolomeev, E.; Vucic, D.; Wagner, A. J.; Wallweber, H. J. A.; Wang, L.; Ware, J.; Wen, Z.; Wong, H.; Wong, J. M.; Wong, M.; Wong, S.; Yu, R.; Zobel, K.; Fairbrother, W. J.
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This research utilizes phytochemical nanoparticles loaded on 3D-printed tricalcium phosphate scaffolds for the treatment of critical bone defects.
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The novel clinical FLAP inhibitor AZD5718 inhibiting FLAP in coronary artery for treatment of coronary artery disease. (Pettersen, D.; et al. J. Med. Chem. 2019, 62, DOI: 10.1021/acs.jmedchem.8b02004) View the article.
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Matter
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On the cover: As reported by Y.S. Zhang and colleagues in this issue of Matter, a cryobioprinting method is optimized for fabricating freeform storable tissue constructs
with shelf availability by taking advantage of the designed cryoprotective bioinks
to maintain the functionality of embedded cells during the cryobioprinting and cryostorage
processes.
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On the cover: This issue of Matter marks the inaugural “Pieces of Matter” issue, with a collection of six invited Perspectives,
five featured in this issue (see the contributions by Buonassisi, Jen/Yip, Loi, Stranks,
Walsh, and Yang) with a focus on a single materials system: perovskites. The cover,
contributed by co-editor of the collection, Yuanyuan Zhou, and created by Ms. Xinran
Xu, from the Advanced Semiconductor Laboratory, Hong Kong Baptist University, depicts
perovskites as the centerpiece to an art gallery exhibition, highlighting illustrative
examples of physics, atomistic structure, device engineering, machine learning, etc.,
i.e. disparate “pieces” that compose a research field.
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On the cover: This month's cover from Hsu and colleagues depicts a red-colored biomaterials film wrapped in a spiral pattern to look like
a rose, sitting in a menstrual cup. The work describes the development of an eco-friendly,
blood-absorbent biomaterial that improves the performance of menstrual products by
minimizing blood leakage and spilling while also helping to prevent infection. The
stark cover counters the stigma of thinking or studying menstruation, using advanced
functional materials for innovative solutions. Image courtesy of the authors.
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On the Cover: This issue of Matter marks the beginning of our second year of publishing. To celebrate, we arranged a
special anniversary issue and invited contributions from a variety of exemplary researchers.
We herein invite the materials science community to help us celebrate an exciting
rookie season and kick off our sophomore year with a piece of symbolic birthday cake,
decorated (of course) with materials. Image credit: Ella Maru Studio.
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Nature Catalysis
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Dispersion control
In their work, L. Robert Baker and colleagues investigate the effects of molecular dispersion of a heterogenized cobalt phthalocyanine on the rate and product selectivity in electrocatalytic CO2 reduction.
See Zhu et al.
Image: Elad Gross and Hadar Shema, Hebrew University, Jerusalem. Cover design: Alex Whitworth.
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Active sites revealed
In their work, the authors present a methodology to map the active sites of nanoparticle catalysts via a combination of atomic electron tomography and first-principles-trained machine learning. This allows them to draw structure–activity relationships and propose a local environment descriptor.
See Yang et al.
Image: Yao Yang, Westlake University. Cover design: Alex Whitworth
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Deactivation into single atoms
By controlling the loading of metal nanoparticles in supported catalysts using colloidal nanocrystals, Cargnello and co-workers report a deactivation mechanism in combustion catalysts that occurs by particle decomposition into inactive single atoms rather than by particle growth. This deactivation process is fast, but is mitigated by the use of higher metal loadings, showing that, for certain reactions, higher particle densities lead to more stable catalysts.
See Goodman et al.
Image: Greg Stewart (SLAC National Accelerator Laboratory). Cover Design: Alex Wing.
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Two eyes on single particles
Weckhuysen and co-workers report a set of catalyst sensors that allow for the simultaneous detection of local temperature and surface species on catalyst particles. This provides a powerful method to monitor, characterize and understand catalytic systems.
See Hartman et al.
Image: Thomas Hartman (Utrecht University). Cover Design: Alex Wing.
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Journal of the American Chemical Society
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This cover image demonstrates the critical role of the solvent in the ion motion of intrinsically anionic metal–organic framework (MOF)-based quasi-solid-state electrolytes (QSSEs). Using hybrid theoretical and experimental approaches, we have identified solvent-assisted hopping as the dominant pathway for Li+ conduction in such materials, exemplified by MOF-688.
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The cover illustrates a rationally designed and synthesized stable, nickel foam-supported, {–210} high-index facet-rich Ni3S2 nanosheet array, dubbed Ni3S2/NF, in action as a highly active, binder-free, bifunctional electrocatalyst for both the hydrogen evolution and the oxygen evolution reactions. See Asefa and co-workers, p 14023. View the article.
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Light promotes electrons in certain positions of a three-dimensional covalent organic framework into collective excited states. Cover art by Alfy Benny.
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A dataset of high-quality band gaps for perovskite materials is first generated through an advanced electronic structure method and then used to develop a simple but accurate band-gap model through artificial intelligence. This enables a search across large databases, leading to the identification of promising halide perovskites for photovoltaic applications.
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Nature Cell Biology
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A collage of Nature Cell Biology covers from the past decade.
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Focus on cell death
The cover shows 3-colour live imaging in vivo demonstrating a role for ferroptosis-like cell death in triggering macrophage recruitment but delaying the resolution of inflammation during wounding in Drosophila. See Focus for more content. Focus
See Davidson et al.
Image: Andrew J. Davidson, University of Glasgow. Cover design: Lauren Heslop
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Organelles
Isolating intact mitochondria from specific cells shows that the Caenorhabditis elegans germline propagates deleterious mitochondrial genomes.
See Ahier et al.
Image: Nick Valmas and Steven Zuryn, University of Queensland. Cover Design: Lauren Heslop.
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Heritable amyloids
Protein amyloid structures are stably inherited across generations and transmit epigenetic memory in Caenorhabditis elegans. Loss of MSTR, a regulator of the amyloid-like structures, results in a transgenerational feminization phenotype.
See Eroglu et al.
Image: Matthew Eroglu, SickKids Hospital & University of Toronto. Cover design: Lauren Heslop
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Nature Physics
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Electrons in a fractal
Electrons are confined to an artificial Sierpiński triangle. Microscopy measurements show that their wavefunctions become self-similar and their quantum properties inherit a non-integer dimension between 1 and 2.
See Morais-Smith et al.
Image: Marlou Slot, Utrecht University. Cover Design: David Shand.
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Two-state cell migration
Two-state micropatterns offer a unique platform to study cell migration. An equation of motion is inferred from a large ensemble of trajectories, revealing key differences in the nonlinear dynamics of healthy and cancerous cells.
See Broedersz et al.
Image: Christoph Hohman, Nanosystems Initiative Munich (NIM). Cover Design: David Shand
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Charge on the bouncing barrier
In our understanding of planetary formation, it is still unclear how millimetre-sized dust grains grow into centimetre-sized aggregates. Microgravity experiments now show that electrical charging of the grains leads to the formation of larger clumps.
See Steinpilz et al.
Image: Tobias Steinpilz. Cover Design: Lauren Heslop
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Active holes break multicellular bridges
The formation of holes in epithelial tissue is important for development but can also lead to problems, including cancer, if the process does not work smoothly. Jian-Qing Lv and collaborators have tracked the nucleation, coalescence, and eventual formation of a network of holes in monolayer epithelioid tissues. In particular, they found a fracture–slip mechanism that takes place during hole coalescence and enables the breaking of multicellular bridges without deforming cells too strongly. These results show that the mechanics of living tissues are coordinated across multiple length scales so that holes can form with minimal risk of mechanical damage.
See Jian-Qing Lv et al.
Image: Jian-Qing Lv, Tsinghua University. Cover design: Emily Paul
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Nature Cardiovascular Research
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Reaching out
The cover image of our first issue is a wool artwork entitled ‘Reach’, created by contemporary British artist Sarah Vaci. Reflecting the originality and courage of the artwork, Nature Cardiovascular Research aims to bring together the cardiovascular and blood community, and promote, champion and disseminate inspiring, thought-provoking and original research.
Image: Sarah Vaci. Cover Design: Bethany Vukomanovic
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COVID-19 and atherosclerosis
Eberhardt et al. describe how SARS-CoV-2 infects cells within human atherosclerotic lesions, triggering plaque inflammation that contributes to acute cardiovascular complications and long-term risks in patients with COVID-19.
See Eberhardt et al.
Image: Katie Vicari. Cover design: Bethany Vukomanovic
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Explaining heart failure
Fernandez-Patron et al. propose a unifying framework explaining how diverse risk factors such as hypertension, obesity and diabetes lead to the pathogenesis and progression of heart failure.
See Fernandez-Patron et al.
Image: Eugenio Hardy, Center for Molecular Immunology, Cuba and Carlos Fernandez-Patron, University of Alberta, Canada. Cover design: Bethany Vukomanovic
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Collateral arteries of the heart
The figure adapted from Anbazhakan et al. represents imaging (black and white), hemodynamic forces (magenta), and collateral artery tracing (cyan) in a cohesive collage. The use of a collage symbolizes the interdisciplinary nature of this work.
See Anbazhakan et al. and News & Views by Mayerich and Wythe
Image: Suhaas Anbazhakan and Pamela E. Rios Coronado. Cover Design: Bethany Vukomanovic
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NATURE BIOTECHNOLOGY
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Point-of-care monitoring
A miniaturized ultrasonic system can provide full-body monitoring and diagnosis. Lin et al. engineer a soft, wireless ultrasound device to measure deep body signals in moving subjects, offering a hands-free solution for continuous, comprehensive health tracking at the point of care.
See Lin et al.
Image: Muyang Lin, University of California San Diego. Cover design: Erin Dewalt.
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Focus on wearable sensors
Wearable sensors are evolving to provide accurate, continuous and wireless monitoring of our health and disease states. Using designs and materials that interface seamlessly with skin, accessing a range of bodily fluids with minimally invasive systems, and measuring analytes that inform on human physiology, wearable devices are poised to provide data resources for research and clinical applications.
See In this issue
Image: J. Rogers, Northwestern University. Cover Design: Erin Dewalt.
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Nature Biotechnology celebrates its 20-year anniversary. Cover art: Erin Boyle
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Nature Biotechnology celebrates 15 years of publishing the very best of biotech science and business. Cover art: Marina Corral.
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Cell Reports Methods
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On the cover: Biological samples are often examined at the cellular level in order
to draw conclusions or suggest an appropriate medical diagnosis. In this issue, Toth
et al. report a method that improves cell classification accuracy using a fisheye-like
transformation that incorporates the environment around a cell of interest. This paper
is one of several being published as part of a joint special collection of papers
across Cell Reports portfolio journals focused on artificial intelligence. The cover
image represents two fishermen, where the one that uses the properly designed net
(similar to the fisheye transformation’s sampling net) can catch more cells. Cover
credit: Akos Diosdi and Timea Toth.
|
MAC_Bench/Cell/Story/Cell Reports Methods/2_1.txt
|
clip
|
2_1.txt
|
On the cover: Welcome to Cell Reports Methods! Our first issue cover features original artwork, from the Cell Press creative team,
that conceptualizes the process of scientific discovery as navigating a complex and
varied mountain terrain with many possible goals and endpoints. At Cell Reports Methods, we are devoted to research that provides the tools and methods needed to conquer
this terrain and achieve scientific progress. Image credit: Kip Lyall.
|
MAC_Bench/Cell/Story/Cell Reports Methods/1_8.txt
|
vitg
|
1_8.txt
|
On the cover: The cover image illustrates MMoCHi, a supervised machine learning framework
for cell-type classification of multimodal, single-cell genomics and spatial profiling
data developed by Caron et al. The colored layers and corresponding cell drawings represent different modalities
(e.g., morphology, protein, mRNA), with the bottom row showing the final, classified
form. The images at the bottom are micrographs of lymph nodes, with the colored annotations
from MMoCHi on the right. Credit: Daniel P. Caron.
|
MAC_Bench/Cell/Story/Cell Reports Methods/5_1.txt
|
groundtruth
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5_1.txt
|
On the cover: In this issue, Quarles et al. present a method for high-throughput cryosectioning of hundreds of C. elegans in a single block, enabling improved access to antigens for immunostaining. As shown
in the cover image, they use this method to establish C. elegans as a multicellular model for studying the function of inorganic polyphosphate (depicted
in green). Image courtesy of Ellen Quarles.
|
MAC_Bench/Cell/Story/Cell Reports Methods/4_3.txt
|
ave_3
|
4_3.txt
|
val
|
Organometallics
|
2025_2
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/Organometallics/2025_2.png
|
D
|
What is the application? Consider how organometallic expertise can be extended to determine and realize new translational research opportunities. The diverse applications of organometallic chemistry featured in this Special Issue continue to inspire creative directions and novel approaches within the discipline.
|
MAC_Bench/ACS/Story/Organometallics/2024_5.txt
|
ave_1
|
2024_5.txt
|
Sustainable Organometallic Chemistry is important to develop new processes that are less dependent on finite natural resources. This Special Issue focuses on various approaches to replace nonsustainable chemical reagents with more sustainable alternatives. The cover art depicts some of the ingredients that are needed to make a fully sustainable organometallic reaction: earth-abundant metals, green ligands, sustainable solvents, and abundant starting materials. The molecules shown originate from the work featured in this Special Issue. The cover art was designed by Kathrin H. Hopmann and Jennifer V. Obligacion, with technical assistance from Jeff H. Ward.
|
MAC_Bench/ACS/Story/Organometallics/2022_11.txt
|
vith
|
2022_11.txt
|
The future is shining bright for organometallics. This special issue shines light on photo-active organometallic complexes and their applications as photoredox catalysts.
|
MAC_Bench/ACS/Story/Organometallics/2024_9.txt
|
clip
|
2024_9.txt
|
This cover art is a concise and retro-artistic representation of our research, a synthesis using high-pressure nitrogen. In this work, we have succeeded for the first time in analyzing the single crystal structure of a dinitrogen complex, [Cr(PCy3)2(CO)3(N2)], which has been known for a long time. We also revealed the very interesting property of disorder of the nitrogen and carbonyl ligands in the crystal by polarized infrared spectroscopy. The cover art was designed by Shinya Takaishi and created by using Open AI DALL-E 3.
|
MAC_Bench/ACS/Story/Organometallics/2025_2.txt
|
groundtruth
|
2025_2.txt
|
train
|
NATURE REVIEWS MICROBIOLOGY
|
22_2
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_2.png
|
C
|
Harnessing the microbiome for sustainable crop production, inspired by the Review on p9
Cover design: Amie Fernandez
|
MAC_Bench/Nature/Story/NATURE REVIEWS MICROBIOLOGY/23_2.txt
|
ave_3
|
23_2.txt
|
The indoor microbiome, inspired by the Review on p742.
Cover design: Amie Fernandez
|
MAC_Bench/Nature/Story/NATURE REVIEWS MICROBIOLOGY/22_1.txt
|
vitg
|
22_1.txt
|
Feeding the microbiome, inspired by the Review on p671.
Cover design: Amie Fernandez
|
MAC_Bench/Nature/Story/NATURE REVIEWS MICROBIOLOGY/22_2.txt
|
groundtruth
|
22_2.txt
|
Microbial food spoilage, inspired by the Review on p528.
Cover design: Amie Fernandez
|
MAC_Bench/Nature/Story/NATURE REVIEWS MICROBIOLOGY/22_4.txt
|
clip
|
22_4.txt
|
train
|
Trends in Chemistry
|
7_1
|
Which of the following options best describe the cover image?
|
MAC_Bench/Cell/Cover/Trends in Chemistry/7_1.png
|
D
|
In this special issue of Trends in Chemistry, we wrap up our inaugural content by continuing to address big questions in chemistry.
We introduce 14 new articles outlining key topics in chemistry including: lithium-metal
batteries; electrochemical water splitting; light hydrocarbon separations; glycosidic
bond hydroxylation; and two dimensional materials, just to name a few. The cover image
is a continuation of the Issue 1 cover but now with a collection of molecules, structures
and reactions primarily found within this issue.
|
MAC_Bench/Cell/Story/Trends in Chemistry/1_9.txt
|
clip
|
1_9.txt
|
Over the past decade, machine learning algorithms (MLAs) have been employed extensively
to speed up the discovery, synthesis, and optimization of molecules and materials.
This Special Issue highlights key areas where machine learning has made, and will
continue to make, a positive impact on molecular and materials research. One prime
example is the application of MLAs in homogeneous catalysis. On pages 96-110 of this
Special Issue, Aspuru-Guzik and colleagues unveil their vision for the future of machine
learning in homogeneous catalyst design by highlighting emerging technologies and
methods that are likely to have a lasting impact on the field. By closing the loop
of machine learning guided experiment design and autonomous experimentation, new catalysts
can be designed at an unprecedented pace. Image credit: the Aspuru-Guzik group (University
of Toronto). Created by: Gabriel dos Passos Gomes.
|
MAC_Bench/Cell/Story/Trends in Chemistry/3_12.txt
|
vith
|
3_12.txt
|
In this special issue of Trends in Chemistry, we highlight the design and emerging catalytic applications of transition metals
and their complexes in organic and organometallic chemistry, including: C-C bond formation,
C-H functionalization, branch-selective olefin hydroarylation, carbon-dioxide methanation,
and chemo-catalytic cellulose conversion to ethanol. On pages 510–523 of this issue,
Rueping and colleagues discuss visible light-induced excited-state transition-metal
catalysis. In contrast to metal/photoredox dual catalysis which has garnered significant
attention as a bond-forming platform, excited-state transition-metal catalysis employs
a single metal complex as both the photo- and cross-coupling catalyst, offering potential
efficient and economic C-C bond formation.
|
MAC_Bench/Cell/Story/Trends in Chemistry/1_5.txt
|
vitg
|
1_5.txt
|
Polyoxovanadates (POVs) are a versatile class of metal-oxido clusters
with excellent solution, redox and thermal stability, and are particularly noted for
binding
to various peptide and protein targets with various therapeutic outcomes. In their
Forum article in this issue, Merlino and co-workers discuss recent data on the structural
features and binding mechanisms of POVs with proteins, to help better elucidate
structure-property-function correlation. These studies can aid the development of
new
POVs, help to better understand their biological action, suggest new uses for known
structures and break into wider fields like biohybrid materials and energy process
engineering.
Cover image credit: Prof. Antonello Merlino
|
MAC_Bench/Cell/Story/Trends in Chemistry/7_1.txt
|
groundtruth
|
7_1.txt
|
test
|
NATURE REVIEWS DRUG DISCOVERY
|
23_7
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_7.png
|
A
|
A framework for RNA-based medicines, inspired by the Review on p421.
Cover design: S. Harris
|
MAC_Bench/Nature/Story/NATURE REVIEWS DRUG DISCOVERY/23_7.txt
|
groundtruth
|
23_7.txt
|
Evolution of therapeutic strategies for COVID-19, inspired by the Review on p449.
Cover design: S. Harris
|
MAC_Bench/Nature/Story/NATURE REVIEWS DRUG DISCOVERY/22_7.txt
|
vitg
|
22_7.txt
|
Targeting hypoxia-inducible factors, inspired by the Review on p175.
Cover design: S. Harris
|
MAC_Bench/Nature/Story/NATURE REVIEWS DRUG DISCOVERY/23_10.txt
|
vith
|
23_10.txt
|
Delivering genome editors, inspired by the Review on p875.
Cover design: S. Harris
|
MAC_Bench/Nature/Story/NATURE REVIEWS DRUG DISCOVERY/22_2.txt
|
clip
|
22_2.txt
|
train
|
Nature Reviews Nephrology
|
20_7
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_7.png
|
A
|
Kidney-targeted nanomedicines, inspired by the Review on p354.
Cover design: Lara Crow
|
MAC_Bench/Nature/Story/Nature Reviews Nephrology/20_7.txt
|
groundtruth
|
20_7.txt
|
Unlocking tissue-specific T cell responses, inspired by the Review on p209.
Cover design: Lara Crow
|
MAC_Bench/Nature/Story/Nature Reviews Nephrology/18_9.txt
|
clip
|
18_9.txt
|
Endothelial cell metabolism, inspired by the Review on p441.
Cover design: Lara Crow
|
MAC_Bench/Nature/Story/Nature Reviews Nephrology/17_6.txt
|
vith
|
17_6.txt
|
COVER: The intracellular complement system, inspired by the Review on p426.
Cover design: Lara Crow
|
MAC_Bench/Nature/Story/Nature Reviews Nephrology/19_6.txt
|
vitg
|
19_6.txt
|
train
|
ACS Chemical Neuroscience
|
2024_12
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2024_12.png
|
A
|
ᴅ-glucose ([18F]FDG) PET imaging. [18F]FDG PET offers a quantitative and translational neuroimaging method to explore the CNS effects of candidate drugs for smoking cessation therapy.
|
MAC_Bench/ACS/Story/ACS Chemical Neuroscience/2024_12.txt
|
groundtruth
|
2024_12.txt
|
10.1021/acschemneuro.0c00004
|
MAC_Bench/ACS/Story/ACS Chemical Neuroscience/2020_21.txt
|
clip
|
2020_21.txt
|
The mechanisms accounting for the formation of pores by amyloid peptides are revealed by unbiased all-atom simulations. Peptides adsorb, aggregate into β-sheets, and form pores spontaneously at the surface of lipid bilayers. Four peptides differing in the distribution of polar and nonpolar residues along the sequence are investigated.
|
MAC_Bench/ACS/Story/ACS Chemical Neuroscience/2024_7.txt
|
vith
|
2024_7.txt
|
.
|
MAC_Bench/ACS/Story/ACS Chemical Neuroscience/2010_12.txt
|
vitg
|
2010_12.txt
|
train
|
ACS ES&T Water
|
2025_2
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/ACS ES&T Water/2025_2.png
|
B
|
Read the recent Collection on Wastewater-Based Epidemiology
|
MAC_Bench/ACS/Story/ACS ES&T Water/2024_6.txt
|
vitg
|
2024_6.txt
|
This Special Issue entitled “3D Printing Technologies for Environmental and Water Applications” highlights the diverse applications of 3D printing technologies in environmental sectors. Owing to their exceptional efficiency, flexible structures, and ease of recovery, 3D-printed catalysts hold significant potential for addressing practical challenges in real-world water environments. The cover artwork was created using OpenAI.com.
|
MAC_Bench/ACS/Story/ACS ES&T Water/2025_2.txt
|
groundtruth
|
2025_2.txt
|
Welcome to the inaugural issue of ACS ES&T Water, a multidisciplinary journal dedicated to all aspects of water research and policy. Research investigating water quality, chemistry, treatment, protection, and sustainable use/reuse and supply is in scope. The journal considers freshwater and marine environments, and industrial and municipal water applications.
|
MAC_Bench/ACS/Story/ACS ES&T Water/2021_12.txt
|
vith
|
2021_12.txt
|
Predicting daily discharge of wastewater treatment plants (WWTPs) using a machine learning model supported by meteorological and population migration big data in the Guangdong-Hong Kong-Macao Greater Bay Area of China.
|
MAC_Bench/ACS/Story/ACS ES&T Water/2023_8.txt
|
clip
|
2023_8.txt
|
train
|
NATURE MEDICINE
|
30_1
|
Which of the following options best describe the cover image?
|
MAC_Bench/Nature/Cover/NATURE MEDICINE/30_1.png
|
A
|
Human Cell Atlas
In this issue, multiple studies from the Human Cell Atlas report findings from human single-cell and spatial genomics datasets of vascular cells, healthy female breast tissues, placentas, and lung tissues from people with fatal COVID-19. The cover depicts these data projected onto a multifaceted lantern. The shapes and colors indicate the myriad cell states in the human body in different organs and tissues, and the diversity of the human population, with unfinished areas representing data still yet to be explored.
See Barnett et al., Bhat-Nakshatri et al., Ounadjela et al. and Nyirenda et al.
Image: Dinithi Sumanaweera, University of Cambridge, and Su Min Suh, SciStories. Cover design: Marina Spence
|
MAC_Bench/Nature/Story/NATURE MEDICINE/30_1.txt
|
groundtruth
|
30_1.txt
|
30th anniversary issue: the Future of Medicine
As Nature Medicine turns 30 years old, we will, throughout 2025, be looking at the future of medicine. In this first issue, we turn our attention to next-generation drug discovery.
Image and cover design: Alex Whitworth
|
MAC_Bench/Nature/Story/NATURE MEDICINE/31_1.txt
|
clip
|
31_1.txt
|
In 2004, Nature Medicine enters its tenth year of publication, continuing our mission to serve the biomedical research community as the venue for top-flight primary research articles, news and perspectives. The cover image commemorates our anniversary year with a collage of covers spanning our publication history. (Graphic by Lewis Long)
|
MAC_Bench/Nature/Story/NATURE MEDICINE/10_12.txt
|
ave_1
|
10_12.txt
|
Medicine in the digital age
As Nature Medicine celebrates its 25th anniversary, we bring our readers a special Focus on Digital Medicine that highlights the new technologies transforming medicine and healthcare, as well as the related regulatory challenges ahead.
See Focus
Image credit: Peter Crowther. Cover design: Erin Dewalt
|
MAC_Bench/Nature/Story/NATURE MEDICINE/25_12.txt
|
vith
|
25_12.txt
|
train
|
ACS ES&T Water
|
2024_3
|
Which of the following options best describe the cover image?
|
MAC_Bench/ACS/Cover/ACS ES&T Water/2024_3.png
|
C
|
The editors at ACS ES&T Water are pleased to announce the winners of the 2022 ACS ES&T Water Best Paper Award, showcasing some of the most outstanding papers published in 2022 issues. The front cover lists the topics covered by the winners of the award. Please view the Editorial for full information on the winning papers. Congratulations to the authors, and a sincere thank you to all authors in the journal for their commitment to excellence and for publishing their best work in ACS ES&T Water.
|
MAC_Bench/ACS/Story/ACS ES&T Water/2023_1.txt
|
vith
|
2023_1.txt
|
Welcome to the inaugural issue of ACS ES&T Water, a multidisciplinary journal dedicated to all aspects of water research and policy. Research investigating water quality, chemistry, treatment, protection, and sustainable use/reuse and supply is in scope. The journal considers freshwater and marine environments, and industrial and municipal water applications.
|
MAC_Bench/ACS/Story/ACS ES&T Water/2021_12.txt
|
clip
|
2021_12.txt
|
The superior sensitivity and specificity of qPCR allow for the quantification of algal genera and the discovery of algae response to reservoir characteristics that traditional microscopy methods could not easily detect.
|
MAC_Bench/ACS/Story/ACS ES&T Water/2024_3.txt
|
groundtruth
|
2024_3.txt
|
This special issue showcases the latest advances in membrane technologies to remove and recover valuable resources from water streams. The artwork by Yang et al.
|
MAC_Bench/ACS/Story/ACS ES&T Water/2023_6.txt
|
ave_2
|
2023_6.txt
|
train
|
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