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instruction:
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
question:
Question: Does the phospholipase A ( 2 ) inhibitor methyl indoxam suppress diet-induced obesity and glucose intolerance in mice?
Answer: These results show that oral supplementation of a diabetogenic diet with the Pla2g1b inhibitor methyl indoxam effectively suppresses diet-induced obesity and diabetes in mice. This suggests that Pla2g1b inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes.
answer:
yes
question:
Question: Is the WFS1 ( Wolfram syndrome 1 ) a major susceptibility gene for the development of psychiatric disorders?
Answer: Our results suggest that WFS1 is not a major susceptibility gene for the development of psychiatric disorders in our population.
answer:
no
question:
Question: Is late follicular progesterone to estradiol ratio influenced by protocols or gonadotropins used?
Answer: Endometrial receptivity is determined by the complex interactions of E2 and P.
answer:
| no
| task846_pubmedqa_classification |
|
TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Does usability testing found problems for novice users of pediatric portals?
Answer: Despite parental involvement and prior heuristic testing, scenario-based testing demonstrated difficulties in navigation, medical language complexity, error recovery, and provider-based organizational schema. While such usability testing can be expensive, the current study demonstrates that it can assist in making healthcare system interfaces for laypersons more user-friendly and potentially more functional for patients and their families.
SOLUTION: yes
PROBLEM: Question: Does a null mutation in ANGPTL8 associate with either plasma glucose or type 2 diabetes in humans?
Answer: Disruption of ANGPTL8 function in humans does not seem to have a large effect on measures of glucose tolerance.
SOLUTION: no
PROBLEM: Question: Is horizontal gene transfer in bdelloid rotifers ancient , ongoing and more frequent in species from desiccating habitats?
Answer: Nearly half of foreign genes were acquired before the divergence of bdelloid families over 60 Mya. Nonetheless, HGT is ongoing in bdelloids and has contributed to putative functional differences among species. Variation among our study species is consistent with the hypothesis that desiccating habitats promote HGT.
SOLUTION: | yes
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Are leg muscle reflexes mediated by cutaneous A-beta fibres normal during gait in reflex sympathetic dystrophy?
Answer: In the acute phase of RSD of the lower extremity there is no evidence for abnormal A-beta fibre-mediated reflexes or for defective regulation of such reflexes. This finding has implications for both the theory on RSD pathophysiology and RSD models, which are based on abnormal functioning of A-beta fibres.
yes
Question: Does diabetes influence oral oncogenesis through fibroblast growth factor receptors?
Answer: It seems that diabetes does not affect the FGFR-2 and FGFR-3 pattern of expression throughout the various stages of oral oncogenesis.
no
Question: Does fatigue-induced ACL injury risk stem from a degradation in central control?
Answer: Unilateral fatigue induces a fatigue crossover to the contralateral limb during single-leg landings. Central fatigue thus seems to be a critical component of fatigue-induced sports landing strategies. Hence, targeted training of central control processes may be necessary to counter successfully the debilitative impact of fatigue on ACL injury risk.
| yes
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example Input: Question: Does a null mutation in ANGPTL8 associate with either plasma glucose or type 2 diabetes in humans?
Answer: Disruption of ANGPTL8 function in humans does not seem to have a large effect on measures of glucose tolerance.
Example Output: no
Example Input: Question: Does the extent of lymphadenectomy for pTXNO prostate cancer affect prostate cancer outcome in the prostate specific antigen era?
Answer: The extent of lymphadenectomy does not appear to affect prostate cancer outcome in lymph node negative cases. This includes patients with high preoperative PSA, high pathological grade and extracapsular disease. These results suggest that under staging is not present in apparently node negative cases with limited lymphadenectomy and, even if present, its impact on outcome is likely to be negligible.
Example Output: no
Example Input: Question: Does timing of Emergency Medicine Student Evaluation Affect Scoring?
Answer: The evaluation score was not affected by timing of the evaluation. Variance in scores was similar for both immediate and delayed evaluations. Considerable amounts of time and energy are expended tracking down delayed evaluations. This activity does not impact a student's final grade.
Example Output: | no
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example Input: Question: Are respiratory disorders more common in farmers . Results from a study on Icelandic animal farmers?
Answer: The prevalence of respiratory disorders and symptoms among Icelandic farmers is currently similar to non-farmers. This may suggest that modernization of the agricultural environment has had a positive effect on workers' health.
Example Output: no
Example Input: Question: Is neutrophil-lymphocyte ratio a reliable predictive marker for early-stage diabetic nephropathy?
Answer: Increased NLR was significantly associated with DN, and high NLR values may be a reliable predictive marker of early-stage DN.
Example Output: yes
Example Input: Question: Does methotrexate inhibit NF-κB activity via long intergenic ( noncoding ) RNA-p21 induction?
Answer: Our findings support a model whereby depressed levels of lincRNA-p21 in RA contribute to increased NF-κB activity. MTX decreases basal levels of NF-κB activity by increasing lincRNA-p21 levels through a DNA PKcs-dependent mechanism.
Example Output: | yes
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Is muscle dysfunction during exercise of a single skeletal muscle in rats with congestive heart failure associated with reduced muscle blood supply?
Answer: The cause of contractile dysfunction in a single exercising skeletal muscle in rats with CHF cannot be explained simply by reduced blood supply. In addition, absence of changes in high-energy phosphates and metabolites indicate that the oxidative metabolism of SOL is intact in rats with CHF.
A: no
****
Q: Question: Do patients with ClearCode34-identified molecular subtypes of clear cell renal cell carcinoma represent unique populations with distinct comorbidities?
Answer: ClearCode34, after considering distinct patterns of comorbidities in each molecular subtype, remains a strong prognostic tool in patients with ccRCC. Obesity and diabetes mellitus emerged as factors that may influence ccRCC phenotypes and further studies investigating the effect of these metabolic conditions functionally onto tumor biology are warranted. Additionally, use of angiotensin system inhibitors could be studied in the context of ccRCC molecular classification in future studies to better understand its effect on ccRCC outcomes.
A: yes
****
Q: Question: 's it just the big kids : both high and low BMI impact bracing success for adolescent idiopathic scoliosis?
Answer: Based on our results, children on either end of the BMI spectrum are more likely to fail brace treatment for scoliosis than their mid-BMI counterparts. In high-BMI patients, this appears to be in large part attributable to an inadequacy of in-brace curve correction as well as to poorer brace compliance, while a low BMI appears to be an independent risk factor for brace failure.
A: | no
****
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[Q]: Question: Is meconium ileus in cystic fibrosis linked to central repetitive region length variation in MUC1 , MUC2 , and MUC5AC?
Answer: The genetic length variants in the central repetitive region of three MUC genes studied are not associated with MI in subjects with CF.
[A]: no
[Q]: Question: Does peroxiredoxin 1 promote pancreatic cancer cell invasion by modulating p38 MAPK activity?
Answer: Prdx1 associates with the formation of membrane protrusions through modulation of the activity of p38 MAPK, which in turn promotes PDAC cell invasion.
[A]: yes
[Q]: Question: Is low catalase activity in blood associated with the diabetes caused by alloxan?
Answer: These results indicate that low catalase activity in the blood is associated with the diabetes mellitus caused by alloxan administration.
[A]: | yes
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Example solution: yes
Example explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Problem: Question: Does inhibition of mitochondrial permeability transition pore restore the cardioprotection by postconditioning in diabetic hearts?
Answer: The loss of cardioprotection by IPostC in diabetic state can be overcome by increasing the potency of protective IPostC through its co-application with mPTP inhibition.
| Solution: yes | task846_pubmedqa_classification |
|
Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Are fundus autofluorescence lifetimes increased in non-proliferative diabetic retinopathy?
Answer: Fundus Fluorescence lifetimes are significantly increased in NPDR while lens lifetimes are shorter in the patient group. Lifetime changes might be indicative for the accumulation of advanced glycation end products (AGEs) which enables detection of the disease with high sensitivity and specificity possibly bearing diagnostic merit.
Student: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Ex Input:
Question: Does detection of molecular bacterascites in decompensated cirrhosis define a risk with decreased survival?
Answer: BactDNA quantification in ascitic fluid samples using culture-independent 16S rRNA gene-based methods seems to be an interesting approach to identify patients at risk of reduced survival. Our study warrants further evaluation of antibiotic treatment in patients with molecular bacterascites.
Ex Output:
yes
Ex Input:
Question: Does a null mutation in ANGPTL8 associate with either plasma glucose or type 2 diabetes in humans?
Answer: Disruption of ANGPTL8 function in humans does not seem to have a large effect on measures of glucose tolerance.
Ex Output:
no
Ex Input:
Question: Is cerebellar Purkinje cell loss pathognomonic of essential tremor?
Answer: Our study militates against the hypothesis that PC loss is pathognomonic of ET.
Ex Output:
| no
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Ex Input:
Question: Do patients with ClearCode34-identified molecular subtypes of clear cell renal cell carcinoma represent unique populations with distinct comorbidities?
Answer: ClearCode34, after considering distinct patterns of comorbidities in each molecular subtype, remains a strong prognostic tool in patients with ccRCC. Obesity and diabetes mellitus emerged as factors that may influence ccRCC phenotypes and further studies investigating the effect of these metabolic conditions functionally onto tumor biology are warranted. Additionally, use of angiotensin system inhibitors could be studied in the context of ccRCC molecular classification in future studies to better understand its effect on ccRCC outcomes.
Ex Output:
yes
Ex Input:
Question: Does developmental changes in spatial distribution of in vivo fluorescence and epidermal UV absorbance over Quercus petraea leave?
Answer: The spatial pattern of epidermal UV-screen over the area of oak leaves is related to leaf anatomy during development. In vivo spectroscopy and fluorescence imaging of the leaf surface showed the distribution of pigments within the leaf and hence can provide a tool to monitor optically the leaf development in nature.
Ex Output:
yes
Ex Input:
Question: Does antibiotic-Induced Gut Microbiota Disruption decrease TNF-α Release by Mononuclear Cells in Healthy Adults?
Answer: In this proof-of-principle study of healthy subjects, microbiota disruption by broad-spectrum antibiotics is reversibly associated with decreased systemic cellular responsiveness towards LPS. The implications of these findings in a clinical setting remain to be determined.
Ex Output:
| yes
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[EX Q]: Question: Are front-of-pack symbols a reliable indicator of products with healthier nutrient profiles?
Answer: FOP symbols are being used to market foods that are no more nutritious than foods without this type of marketing. Because FOP symbols may influence consumer perceptions of products and their purchases, it may be a useful public health strategy to set minimum nutritional standards for products using FOP symbol marketing.
[EX A]: no
[EX Q]: Question: Does the phospholipase A ( 2 ) inhibitor methyl indoxam suppress diet-induced obesity and glucose intolerance in mice?
Answer: These results show that oral supplementation of a diabetogenic diet with the Pla2g1b inhibitor methyl indoxam effectively suppresses diet-induced obesity and diabetes in mice. This suggests that Pla2g1b inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes.
[EX A]: yes
[EX Q]: Question: Does the phospholipase A ( 2 ) inhibitor methyl indoxam suppress diet-induced obesity and glucose intolerance in mice?
Answer: These results show that oral supplementation of a diabetogenic diet with the Pla2g1b inhibitor methyl indoxam effectively suppresses diet-induced obesity and diabetes in mice. This suggests that Pla2g1b inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes.
[EX A]: | yes
| task846_pubmedqa_classification |
|
You will be given a definition of a task first, then some input of the task.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does caffeine modify blood glucose availability during prolonged low-intensity exercise in individuals with type-2 diabetes?
Answer: Supplementation with 1.5 mg/kg of caffeine reduces BG concentration during prolonged exercise in T2DM patients.
Output: | yes | task846_pubmedqa_classification |
|
Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Does casein glycomacropeptide-derived peptide IPPKKNQDKTE ameliorate high glucose-induced insulin resistance in HepG2 cells via activation of AMPK signaling?
Answer: IPPKKNQDKTE prevents high glucose-induced insulin resistance in HepG2 cells by modulating the IRS-1/PI3K/Akt signaling pathway through AMPK activation, indicating that IPPKKNQDKTE plays a potential role in the prevention and treatment of hepatic insulin resistance and type 2 diabetes.
Student: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
One example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution is here: yes
Explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Now, solve this: Question: Are fundus autofluorescence lifetimes increased in non-proliferative diabetic retinopathy?
Answer: Fundus Fluorescence lifetimes are significantly increased in NPDR while lens lifetimes are shorter in the patient group. Lifetime changes might be indicative for the accumulation of advanced glycation end products (AGEs) which enables detection of the disease with high sensitivity and specificity possibly bearing diagnostic merit.
Solution: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Are c3 and C4 strongly related to adipose tissue variables and cardiovascular risk factors?
Answer: A strong relation between C3, C4 and C3a-desArg levels, adipose tissue and risk factors of CVD was established. The data support that the adipose tissue produces complement components and generates initiators of inflammation, such as C3a and C5a, able to trigger a cyto/chemokine response, in proportion to the amount of adipose tissue. This corroborates the concept that complement contributes to the low-grade inflammation associated with obesity.
A: yes
****
Q: Question: Is cDK10 a target for aberrant DNA methylation in breast cancer?
Answer: CDK10 is not a target for aberrant DNA methylation in breast cancer.
A: no
****
Q: Question: Is osteoprotegerin associated with subclinical left ventricular systolic dysfunction in diabetic hypertensive patients : a speckle tracking study?
Answer: Plasma OPG values could predict subclinical LV systolic dysfunction in diabetic hypertensive patients.
A: | yes
****
| task846_pubmedqa_classification |
|
Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Is for the majority of patients with diabetes blood pressure and lipid management in line with recommendations . Results from a large population-based cohort in Germany?
Answer: For most elderly with diabetes cardiovascular risk factor management continues to be not in line with recommendations.
A: | no | task846_pubmedqa_classification |
|
You will be given a definition of a task first, then an example. Follow the example to solve a new instance of the task.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Why? The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
New input: Question: Is fasting serum dipeptidyl peptidase-4 activity independently associated with alanine aminotransferase in type 1 diabetic patients?
Answer: Fasting serum DPP4 activity might be associated with hepatic IR in T1DM patients and a part of soluble DPP4 activity might be of a hepatic origin. Further study investigation is warranted to elucidate this topic.
Solution: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Consider Input: Question: Does monocyte chemoattractant protein-1 or macrophage inflammatory protein-1alpha deficiency affect angiotensin II-induced intimal hyperplasia in carotid artery ligation model?
Answer: These results indicate that MCP-1 or MIP-1alpha may not be essential in mediating the proliferative effects of Ang II, a major pathological changes in intimal hyperplasia in the carotid artery ligation model.
Output: no
Input: Consider Input: Question: Is epidural analgesia superior to local infiltration analgesia in children with cerebral palsy undergoing unilateral hip reconstruction?
Answer: Epidural analgesia is superior to local infiltration analgesia for early postoperative pain management in children with cerebral palsy who undergo unilateral hip reconstruction.
Output: yes
Input: Consider Input: Question: Are variants of neurogenin 3 gene associated with Type II diabetes in Japanese subjects?
Answer: Mutations and polymorphisms of ngn3 gene are not significantly associated with Type II (non-insulin-dependent) diabetes mellitus in the Japanese subjects.
| Output: no
| task846_pubmedqa_classification |
|
Q: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does age at diagnosis predict deterioration in glycaemic control among children and adolescents with type 1 diabetes?
Answer: Older diagnostic age and black race are major risk factors for deterioration in glycemic control early in the course of T1DM. These findings can inform efforts to explore the reasons behind these differences and develop preventive interventions for high-risk patients.
A: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Ex Input:
Question: Does switching types of drug-eluting stents prevent repeated in-stent restenosis in patients with coronary drug-eluting stent restenosis?
Answer: A strategy involving repeated DES implantation was superior to POBA for preventing recurrent restenosis. Treatment with a different type or generation of DES does not appear to reduce the incidence of TLR. Moreover, we identified certain useful factors for facilitating appropriate and early triage in the patients with repeated DES ISR.
Ex Output:
no
Ex Input:
Question: Does stopcock lumen contamination reflect the full burden of bacterial intravenous tubing contamination : analysis using a novel injection port?
Answer: Effluent culture is a more sensitive marker of IV fluid system contamination than injection port lumen culture. A novel protective device on the stopcock (Port Guide) significantly reduced IV fluid system bacterial contamination.
Ex Output:
no
Ex Input:
Question: Does coffee consumption and the risk of latent autoimmune diabetes in adults -- result from a Swedish case-control study?
Answer: Our findings confirm that coffee consumption is associated with a reduced risk of Type 2 diabetes. Interestingly, the findings suggest that coffee may be associated with development of autoimmunity and possibly an increased risk of more Type 1-like latent autoimmune diabetes in adults.
Ex Output:
| yes
| task846_pubmedqa_classification |
|
Given the task definition and input, reply with output. Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Do nondiabetic Mexican-Americans have reduced insulin responses relative to nondiabetic non-Hispanic whites?
Answer: These results suggest that increased insulin resistance rather than decreased insulin secretion is characteristic of nondiabetic Mexican-Americans, a high-risk population for NIDDM.
| no | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does the tissue Doppler imaging derived post-systolic velocity notch originate at the aortic annulus?
Answer: The AA represents the site of the earliest onset and maximal amplitude of the PSN on the longitudinal velocity curve suggesting its mechanism to be that of an energy release at the instant of the aortic valve closure causing an apically directed acceleration of the myocardium. A substantial number of healthy subjects exhibit a second PSN spike predominantly at the level of the AA. Its mechanism remains to be elucidated.
yes
Question: Does electrical stimulation prior to delayed reinnervation enhance recovery in muscles of rats?
Answer: The primary factors that inhibited reinnervation and recovery following delayed reinnervation were not alleviated by the electrical stimulation during the period of muscle denervation.
no
Question: Is fasting serum dipeptidyl peptidase-4 activity independently associated with alanine aminotransferase in type 1 diabetic patients?
Answer: Fasting serum DPP4 activity might be associated with hepatic IR in T1DM patients and a part of soluble DPP4 activity might be of a hepatic origin. Further study investigation is warranted to elucidate this topic.
| yes
| task846_pubmedqa_classification |
|
Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
See one example below:
Problem: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Problem: Question: Does periodontitis promote the diabetic development of obese rat via miR-147 induced classical macrophage activation?
Answer: This study provided new evidence for the positive effect of periodontal inflammation on diabetic development, while the regulatory mechanism of miR-147 on classical macrophage activation, was verified, and presumed to contribute to the impaired glucose tolerance aggravated by periodontitis in obese rats. Besides, this study indicated the application of miR-147 for therapeutic approach in the treatment of diabetes with periodontitis.
Solution: | yes | task846_pubmedqa_classification |
|
TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Does ginsenoside Rg3 improve erectile function in streptozotocin-induced diabetic rats?
Answer: Oral gavage with Rg3 appears to both prevent degeneration of neurons in the dorsal nerves and exert an antioxidant effect in the corpus cavernosum of rats.
SOLUTION: yes
PROBLEM: Question: Does identification of structural alert for liver and kidney toxicity using repeated dose toxicity data?
Answer: It was not possible to assign an unambiguous mode of action for all the SAs, but a mechanistic explanation is provided for some of them. Such achievements may help in the early identification of liver and renal toxicity of substances.
SOLUTION: yes
PROBLEM: Question: Does partial meniscectomy in the presence of severe osteoarthritis hasten the symptomatic progression of osteoarthritis?
Answer: Arthroscopic partial meniscectomy in the presence of Outerbridge grade IV degenerative change is likely to improve symptoms initially in patients with symptomatic meniscal tears and may provide lasting benefit. It does not appear to hasten the progression of the osteoarthritis in these patients.
SOLUTION: | no
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Consider Input: Question: Does lung-protective mechanical ventilation protect against acute kidney injury in patients without lung injury at onset of mechanical ventilation?
Answer: In the present study in critically patients without ALI at onset of mechanical ventilation, lower tidal volume ventilation did not reduce the development or worsening of AKI compared with conventional tidal volume ventilation.
Output: no
Input: Consider Input: Question: Does mPGES-2 deletion remarkably enhance liver injury in streptozotocin-treated mice via induction of GLUT2?
Answer: mPGES-2 deletion enhanced STZ-induced liver toxicity possibly via GLUT2-mediated STZ uptake, independently of diabetes mellitus.
Output: yes
Input: Consider Input: Question: Is collagen fleece-bound fibrin sealant associated with an increased risk of thromboembolic events or major bleeding after its use for haemostasis in surgery : a prospective multicentre surveillance study?
Answer: Collagen fleece-bound fibrin sealant does not appear to be associated with an increased risk of TEEs, major bleeding or immunological events in patients undergoing surgery.
| Output: no
| task846_pubmedqa_classification |
|
TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Does serum HCV RNA titer predict the severity of liver damage in HCV carriers with normal aminotransferase levels?
Answer: In HCV carriers with normal aminotransferase levels viraemia does not predict the grade of HCV-related chronic liver disease (CLD), although subjects with higher HCV RNA levels seem to have more severe fibrosis. Although these data suggest that patients with higher viraemia might have more intense architectural changes and more severe progression of liver disease than those with lower levels of HCV replication, the weak and imprecise correlation leads us to conclude that HCV RNA quantitation is not a useful indicator in clinical practice in the selection of patients for liver biopsy.
SOLUTION: no
PROBLEM: Question: Does oligofructose affect the development of type 1 diabetes mellitus induced by dietary proteins in the diabetes-prone BB rat model?
Answer: In the BB rat model, 5% OF in the diet did not have any protective effects against diet-induced T1DM. The present data do not suggest dietary OF as a promising approach for the dietary prevention of T1DM.
SOLUTION: no
PROBLEM: Question: Does visceral Hypersensitivity be Provoked by 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Ileitis in Rats?
Answer: TNBS injection into the ileum induced transmural ileitis including granuloma and visceral hypersensitivity. As this model mimics clinical manifestations of CD, it may provide a road map to probe the pathogenesis of gut inflammation and visceral hypersensitivity, as well as for establishing the therapeutic protocol for Crohn's ileitis.
SOLUTION: | yes
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example input: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Example output: yes
Example explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Q: Question: Are new users of metformin at low risk of incident cancer : a cohort study among people with type 2 diabetes?
Answer: These results suggest that metformin use may be associated with a reduced risk of cancer. A randomized trial is needed to assess whether metformin is protective in a population at high risk for cancer.
A: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[EX Q]: Question: Is visceral pleural invasion a significant prognostic factor in patients with a part-solid lung cancer?
Answer: VPI may not contribute to the prognosis of patients with part-solid nodules. Thus, upgrading of the TNM stage on the basis of VPI should be carefully considered in these patients.
[EX A]: no
[EX Q]: Question: Is health seeking behaviour of parents of burned children in Bangladesh related to family socioeconomics?
Answer: Education, economic condition and place of residence were found as the contributory factors in choosing service provider. Education to the parents can contribute in changes in health seeking behaviour which ultimately contribute in reducing morbidity and mortality from childhood burn injuries. Including parent's education a national burn prevention program needs to be developed to combat the devastating child injury, burn.
[EX A]: yes
[EX Q]: Question: Is regular Chinese Green Tea Consumption Protective for Diabetic Retinopathy : A Clinic-Based Case-Control Study?
Answer: Diabetic patients who had regularly drunk Chinese green tea every week for at least one year in their lives had a DR risk reduction of about 50% compared with those who had not. Regular Chinese green tea consumption may be a novel approach for the prevention of DR.
[EX A]: | yes
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
One example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution is here: yes
Explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Now, solve this: Question: Does serum α-hydroxybutyrate ( α-HB ) predict elevated 1 h glucose levels and early-phase β-cell dysfunction during OGTT?
Answer: Fasting serum α-HB levels predicted elevated 1 h glucose during OGTT, potentially due to impaired insulin secretion kinetics. This association persisted even in patients with an otherwise normal insulin-glucose homeostasis. Measuring serum α-HB could thus provide a rapid, inexpensive screening tool for detecting early subclinical hyperglycemia, β-cell dysfunction, and increased risk for diabetes.
Solution: | yes | task846_pubmedqa_classification |
|
Definition: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Question: Does protein hydrolysate co-ingestion modulate 24 h glycemic control in long-standing type 2 diabetes patients?
Answer: Co-ingestion of a protein hydrolysate with each main meal does not improve glucose homeostasis over a 24 h period in long-standing type 2 diabetes patients.
Output: | no | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Example solution: yes
Example explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Problem: Question: Is vitamin D status in youth with type 1 and type 2 diabetes enrolled in the Pediatric Diabetes Consortium ( PDC ) worse than in youth without diabetes?
Answer: Vitamin D deficiency/insufficiency is present in a substantial proportion of youth with diabetes, particularly minorities, but the prevalence appears similar to that in youth without diabetes. Further studies are needed to examine whether youth with diabetes would benefit from vitamin D supplementation.
| Solution: no | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Does diabetes influence oral oncogenesis through fibroblast growth factor receptors?
Answer: It seems that diabetes does not affect the FGFR-2 and FGFR-3 pattern of expression throughout the various stages of oral oncogenesis.
A: no
****
Q: Question: Does switching types of drug-eluting stents prevent repeated in-stent restenosis in patients with coronary drug-eluting stent restenosis?
Answer: A strategy involving repeated DES implantation was superior to POBA for preventing recurrent restenosis. Treatment with a different type or generation of DES does not appear to reduce the incidence of TLR. Moreover, we identified certain useful factors for facilitating appropriate and early triage in the patients with repeated DES ISR.
A: no
****
Q: Question: Are objective cancer-related variables associated with depressive symptoms in women treated for early-stage breast cancer?
Answer: Depressive symptoms in women treated for early-stage breast cancer are not associated with objective cancer-related factors. Rather, they are most strongly linked with many subjective psychosocial variables.
A: | no
****
| task846_pubmedqa_classification |
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You will be given a definition of a task first, then some input of the task.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does ginsenoside Rg3 improve erectile function in streptozotocin-induced diabetic rats?
Answer: Oral gavage with Rg3 appears to both prevent degeneration of neurons in the dorsal nerves and exert an antioxidant effect in the corpus cavernosum of rats.
Output: | yes | task846_pubmedqa_classification |
|
TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Is tumor differentiation a risk factor for lymph node metastasis in elderly patients with early gastric cancer?
Answer: Elderly patients with undifferentiated type histology early gastric cancer without other risk factors for lymph node metastasis may be candidates for endoscopic resection.
SOLUTION: no
PROBLEM: Question: Is cardiac autonomic neuropathy in patients with uraemia related to pre-diabetes?
Answer: The prevalence of CAN and impaired glucose tolerance is high in uraemic patients, but impaired glucose tolerance seems to play no significant role in the aetiology of CAN in uraemic patients.
SOLUTION: no
PROBLEM: Question: Do serum cytokine levels correlate with disease activity and severity assessed by brain MRI in multiple sclerosis?
Answer: Our data show that the determination of serum levels of the investigated cytokines and cytokine receptors is not useful as a tool to determine subclinical disease activity and severity as assessed by brain MRI.
SOLUTION: | no
| task846_pubmedqa_classification |
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Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Problem:Question: Is serum paraoxonase-1 activity more closely related to HDL particle concentration and large HDL particles than to HDL cholesterol in Type 2 diabetic and non-diabetic subjects?
Answer: PON-1 activity is more closely related to the HDL particle concentration or large HDL particles than to HDL cholesterol. Impaired PON-1 activity in T2DM is not to a considerable extent explained by altered HDL subfraction levels.
Solution: | yes | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Consider Input: Question: Does serum HCV RNA titer predict the severity of liver damage in HCV carriers with normal aminotransferase levels?
Answer: In HCV carriers with normal aminotransferase levels viraemia does not predict the grade of HCV-related chronic liver disease (CLD), although subjects with higher HCV RNA levels seem to have more severe fibrosis. Although these data suggest that patients with higher viraemia might have more intense architectural changes and more severe progression of liver disease than those with lower levels of HCV replication, the weak and imprecise correlation leads us to conclude that HCV RNA quantitation is not a useful indicator in clinical practice in the selection of patients for liver biopsy.
Output: no
Input: Consider Input: Question: Does thickness of CAD-CAM composite resin overlay influences fatigue resistance of endodontically treated premolars?
Answer: Thick FiltekMZ100 composite resin onlays showed higher fatigue resistance than thin ones and may be associated with fractures that are less subgingival.
Output: yes
Input: Consider Input: Question: Is decline in functional capacity unaffected by diet quality alone or in combination with physical activity among generally healthy older adults with T2D from the NuAge cohort?
Answer: The absence of effect may be explained by characteristics of this healthy sample of OA with T2D who showed relatively good adherence to dietary recommendations (mean C-HEI=70) and were highly functional shown by minimal, clinically non-significant FC decline over 3 years. More research is needed to confirm the role of DQ in preventing FC decline in a larger diabetic sample showing clinically significant FC decline.
| Output: yes
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Example solution: yes
Example explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Problem: Question: Does a diabetes scorecard improve HbA ( 1c ) , blood pressure , lipids , aspirin usage , exercise and diabetes knowledge over 9 months : a randomized controlled trial?
Answer: A diabetes scorecard did not improve glycaemic control, blood pressure control, LDL cholesterol, aspirin usage, exercise or diabetic knowledge in an urban population with uncontrolled Type 2 diabetes.
| Solution: no | task846_pubmedqa_classification |
|
instruction:
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
question:
Question: Does a null mutation in ANGPTL8 associate with either plasma glucose or type 2 diabetes in humans?
Answer: Disruption of ANGPTL8 function in humans does not seem to have a large effect on measures of glucose tolerance.
answer:
no
question:
Question: Is the relationship between insomnia with short sleep duration associated with hypercholesterolemia : a cross-sectional study?
Answer: Insomnia with short sleep duration was associated with increased odds of hypercholesterolemia. Caregivers in clinical practice should watch out for the effect brought by this novel factor.
answer:
yes
question:
Question: Does eIF2A-dependent translational arrest protect leukemia cells from the energetic stress induced by NAMPT inhibition?
Answer: We identified EIF2A phosphorylation as a novel early molecular event occurring in response to NAMPT inhibition and mediating protein synthesis arrest. In addition, our data suggest that tumors exhibiting an impaired LBK1- AMPK- EIF2A response may be especially susceptible to NAMPT inhibitors and thus become an elective indication for this type of agents.
answer:
| yes
| task846_pubmedqa_classification |
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Part 1. Definition
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Part 2. Example
Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Answer: yes
Explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Part 3. Exercise
Question: Does digoxin accelerate progression of diabetic retinopathy?
Answer: These data suggest that digoxin therapy does not adversely affect the course of diabetic retinopathy.
Answer: | no | task846_pubmedqa_classification |
|
Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Does blood pressure rise before the onset of microalbuminuria in children followed from diagnosis of type 1 diabetes . Oxford Regional Prospective Study Group?
Answer: A rise in systemic BP cannot be detected before the first appearance of MA in children with type 1 diabetes. BP rises concurrently with the onset of MA and is also closely related to BMI.
Student: | no | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[Q]: Question: Is time point important for effects of syngeneic bone marrow transplantation for type 1 diabetes in mice?
Answer: These results indicated that syn-BMT should be performed, when diabetes is neither too new-onset nor too late-stage. Tregs represent one mechanism for syn-BMT-induced restoration of immune tolerance in STZ-diabetic mice.
[A]: yes
[Q]: Question: Do natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation?
Answer: Overall, we provide a significant insight into the anticarcinogenic action of erythrodiol and uvaol that may have a potential in prevention and treatment of brain tumors and other cancers.
[A]: yes
[Q]: Question: Is vEGF , VEGFR3 , and PDGFRB protein expression influenced by RAS mutations in medullary thyroid carcinoma?
Answer: This is the first study identifying that the expression of TKI targets differs according to the presence of RAS mutations in MTC. This information could potentially be used to select the most beneficial TKI treatment for these patients.
[A]: | yes
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Are falling insulin requirements associated with adverse obstetric outcomes in women with preexisting diabetes?
Answer: Falling insulin requirements, in women with preexisting diabetes, are associated with an increased risk of complications related to placental dysfunction. Further prospective studies are needed to guide clinical management.
A: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Example solution: yes
Example explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Problem: Question: Does induced-hyperglycemia attenuate erythromycin-induced acceleration of hypertonic liquid-phase gastric emptying in type-I diabetic patients?
Answer: The erythromycin-induced acceleration on gastric emptying of hypertonic liquids in diabetic patients is related to the plasma glucose level. The induced hyperglycemia reduces the erythromycin-induced acceleration of liquid-phase gastric emptying, decreasing the overall gastric emptying rate. In spite of the inhibitory effect of induced hyperglycemia on the gastric emptying of hypertonic liquids, erythromycin is still able to accelerate the emptying rate and could prove to be a useful prokinetic agent under hyperglycemic conditions.
| Solution: yes | task846_pubmedqa_classification |
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Given the task definition and input, reply with output. Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Do serum miRNA biomarkers serve as a fingerprint for proliferative diabetic retinopathy?
Answer: These data provide evidence that serum miRNAs have the potential to be sensitive, cost-effective biomarkers for the early detection of PDR. These biomarkers could serve as a dynamic monitoring factor for detecting the progression of PDR from NPDR.
| yes | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example input: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Example output: yes
Example explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Q: Question: Is the polymorphism Arg585Gln in the gene of the sterol regulatory element binding protein-1 ( SREBP-1 ) a determinant of ketosis prone type 2 diabetes ( KPD ) in Africans?
Answer: The results of this exploratory study show that the polymorphism Arg585Gln in SREBF-1 is not associated with the KPD phenotype. Further studies in larger populations are needed to confirm our findings.
A: | no | task846_pubmedqa_classification |
|
instruction:
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
question:
Question: Does helicobacter pylori infection in Mongolian gerbils initiate hematological diseases?
Answer: A single H. pylori infection is insufficient to cause onset of ITP or IDA and other factors may be required for disease onset.
answer:
no
question:
Question: Does diabetes influence oral oncogenesis through fibroblast growth factor receptors?
Answer: It seems that diabetes does not affect the FGFR-2 and FGFR-3 pattern of expression throughout the various stages of oral oncogenesis.
answer:
no
question:
Question: Does prenatal high-dose vitamin D3 supplementation have balanced effects on cord blood Th1 and Th2 responses?
Answer: Third-trimester high-dose vitD3 supplementation in healthy pregnant women had balanced effects on biomarkers of cord blood Th1 and Th2 responses.
answer:
| yes
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Consider Input: Question: Is diffuse musculoskeletal pain associated with low vitamin D levels or improved by treatment with vitamin D?
Answer: Low vitamin D levels are not associated with diffuse musculoskeletal pain, and treatment with vitamin D does not reduce pain in patients with diffuse pain who have low vitamin D levels.
Output: no
Input: Consider Input: Question: Is increasing exposure to antibody-stimulating proteins and polysaccharides in vaccines associated with risk of autism?
Answer: In this study of MCO members, increasing exposure to antibody-stimulating proteins and polysaccharides in vaccines during the first 2 years of life was not related to the risk of developing an ASD.
Output: no
Input: Consider Input: Question: Does diabetes influence oral oncogenesis through fibroblast growth factor receptors?
Answer: It seems that diabetes does not affect the FGFR-2 and FGFR-3 pattern of expression throughout the various stages of oral oncogenesis.
| Output: no
| task846_pubmedqa_classification |
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Given the task definition, example input & output, solve the new input case.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Output: yes
The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
New input case for you: Question: Does caffeine modify blood glucose availability during prolonged low-intensity exercise in individuals with type-2 diabetes?
Answer: Supplementation with 1.5 mg/kg of caffeine reduces BG concentration during prolonged exercise in T2DM patients.
Output: | yes | task846_pubmedqa_classification |
|
You will be given a definition of a task first, then some input of the task.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Is myostatin expression altered by insulin deficiency and replacement in streptozotocin-diabetic rat skeletal muscles?
Answer: Muscle-specific myostatin expression is not increased under catabolic conditions in insulin-deprived diabetes. Insulin treatment also does not change myostatin transcript levels. The data provide the first assessment of potential interplay between insulin and myostatin and they do not support a major role of circulating insulin in the in vivo regulation of myostatin gene expression. A role of myostatin in muscle catabolism in chronic insulin-deprived diabetes is also not indicated by the current results.
Output: | no | task846_pubmedqa_classification |
|
Given the task definition and input, reply with output. Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does diabetes affect ventricular repolarization and sudden cardiac death risk in patients with dilated cardiomyopathy?
Answer: Diabetes appears to increase the risk of heart failure in patients with DCM without affecting ventricular repolarization parameters and sudden cardiac death risk.
| no | task846_pubmedqa_classification |
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TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Do an update in the palliative management of malignant dysphagia?
Answer: Palliative treatment for oesophageal cancer should be individualized and relate to tumour stage, size and location, the patient's medical condition and his/her personal wishes. The palliative treatment largely includes self-expanding metal stents (SEMS), laser (including photodynamic therapy (PDT)) or a combination of the two to relieve symptoms, this may be employed with or without other treatments such as radiotherapy/chemotherapy (RT/CT) with the aim of reducing tumour bulk and possibly prolonging survival. A multi-disciplinary approach is vital in patients with advanced oesophageal cancer.
SOLUTION: yes
PROBLEM: Question: Does unloading of baroreceptors by carotid occlusion increase heart rate in fetal sheep?
Answer: We conclude that in contrast to adult animals, in fetal sheep carotid occlusion with subsequent unloading of baroreceptors does not increase heart rate even when the baroreflex had been activated by arterial hypertension. It seems likely that stimulation of carotid chemoreceptors prevents the expected baroreceptor mediated heart-rate response.
SOLUTION: no
PROBLEM: Question: Does deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice?
Answer: These results demonstrate that G6pc2 is an important driver for the selection and expansion of islet-reactive CD8(+) T cells infiltrating NOD/ShiLtJ islets. However, autoreactivity to G6pc2 is not essential for the emergence of autoimmune diabetes. The results remain consistent with previous studies indicating that insulin may be the primary autoimmune target, at least in NOD/ShiLtJ mice.
SOLUTION: | no
| task846_pubmedqa_classification |
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Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Question: Does formononetin attenuate hydrogen peroxide ( H2O2 ) -induced apoptosis and NF-κB activation in RGC-5 cells?
Answer: Formononetin may be developed as a antioxidant drug to treat diabetic retinopathy.
Output: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[EX Q]: Question: Are levels of soluble CD30 in cord blood and peripheral blood during childhood correlated with the development of atopic disease or a family history of atopy?
Answer: These findings indicate that the sCD30 concentration in cord blood is not a reliable prognostic indicator of, nor a useful diagnostic marker for, atopic disease in children up to 7 years of age. If such correlations do exist, they might be masked by age-dependent variations in the circulating levels of sCD30, which may reflect individual differences in the maturation of children's immunological responses.
[EX A]: no
[EX Q]: Question: Does effective inhibition of nitric oxide production by aminoguanidine reverse hypotension in endotoxaemic rats?
Answer: AG inhibited NO formation in a dose-dependent way. Yet, AG had no haemodynamic effects, suggesting a minor cardiovascular influence of iNOS in this endotoxin model, in parallel to what has been found in microbial sepsis.
[EX A]: no
[EX Q]: Question: Is the PlA1/A2 polymorphism of platelet glycoprotein IIIa associated with the risk of type 2 diabetes . The Ludwigshafen Risk and Cardiovascular Health study?
Answer: The GPIIIa PlA1/A2 polymorphism is not associated with type 2 diabetes, glucose metabolism, angiographic CHD or myocardial infarction.
[EX A]: | no
| task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[EX Q]: Question: Does oligofructose affect the development of type 1 diabetes mellitus induced by dietary proteins in the diabetes-prone BB rat model?
Answer: In the BB rat model, 5% OF in the diet did not have any protective effects against diet-induced T1DM. The present data do not suggest dietary OF as a promising approach for the dietary prevention of T1DM.
[EX A]: no
[EX Q]: Question: Does combined isometric and vibration training enhance strength beyond that of isometric training alone?
Answer: The present study provides evidence to suggest that there are no greater gains to be incurred by the addition of a vibratory stimulus to traditional strength training.
[EX A]: no
[EX Q]: Question: Is mean platelet volume associated with glycaemic control and retinopathy in patients with type 2 diabetes mellitus?
Answer: This study has shown that an increased MPV is closely associated with poor glycaemic control, which may be a risk factor for diabetic retinopathy. Nonetheless, further prospective studies are needed to assess the relationship between MPV, glycaemic indices and microvascular complications.
[EX A]: | yes
| task846_pubmedqa_classification |
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Given the task definition and input, reply with output. Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Do combined effects of obesity and type 2 diabetes contribute to increased breast cancer risk in premenopausal women?
Answer: Obesity and type 2 diabetes, owing to their effects on adipocytokines and inflammatory mediators, contribute to increased breast cancer risk in premenopausal women. This study emphasizes healthy life style and better management of these metabolic disorders to avoid the pathogenesis of breast cancer and of other chronic diseases.
| yes | task846_pubmedqa_classification |
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Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Do monocytes and neutrophils expressing myeloperoxidase occur in fibrous caps and thrombi in unstable coronary plaques?
Answer: Unstable fibrous caps are more likely to contain MPO-positive cells, neutrophils, and iron-containing macrophages than fibrous caps of stable fibroatheromas. MPO-positive cells in thrombi adjacent to disrupted plaques are associated with occlusive thrombi and are more numerous in diabetic patients.
Student: | yes | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Is osteoprotegerin a Better Serum Biomarker of Coronary Artery Calcification than Osteocalcin in Type 2 Diabetes?
Answer: Our results suggest that OPG is a more useful serum biomarker than OC or ucOC for identifying those at increased risk of arterial calcification in type 2 diabetes.
A: | yes | task846_pubmedqa_classification |
|
Given the task definition and input, reply with output. Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does suv39h1 protect from myocardial ischemia-reperfusion injury in diabetic rats?
Answer: Overexpression of Suv39h1 results in the de-activation of proinflammatory pathways and reduced apoptosis and myocardial injury. Therefore, Suv39h1 might represent a novel therapeutic strategy to reduce I/R injury under diabetic condition.
| yes | task846_pubmedqa_classification |
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Teacher: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? If you are still confused, see the following example:
Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Reason: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Now, solve this instance: Question: Is methylglyoxal associated with changes in kidney function among individuals with screen-detected Type 2 diabetes mellitus?
Answer: In a population of people with screen-detected Type 2 diabetes, we observed associations between methylglyoxal and markers of renal function: 6-year change in methylglyoxal was inversely associated with 6-year change in eGFR. Also, methylglyoxal at baseline was positively associated with ACR at baseline. Our study lends further support to a role for methylglyoxal in the pathogenesis of diabetic nephropathy.
Student: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
One example is below.
Q: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
A: yes
Rationale: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Q: Question: Does short-term exercise training stimulate skeletal muscle ATP synthesis in relatives of humans with type 2 diabetes?
Answer: The ability of short-term exercise to stimulate ATP production distinguished individuals with improved insulin sensitivity from those whose insulin sensitivity did not improve. In addition, the NDUFB6 gene polymorphism appeared to modulate this adaptation. This finding suggests that genes involved in mitochondrial function contribute to the response of ATP synthesis to exercise training.
A: | no | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Do obese first-degree relatives of patients with type 2 diabetes with elevated triglyceride levels exhibit increased β-cell function?
Answer: We characterized FDR-T2DM subjects from central Mexico with NGT and revealed a class of obese subjects with elevated TGs and β-cell function, which may precede PT2DM. | yes | task846_pubmedqa_classification |
|
instruction:
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
question:
Question: Is time point important for effects of syngeneic bone marrow transplantation for type 1 diabetes in mice?
Answer: These results indicated that syn-BMT should be performed, when diabetes is neither too new-onset nor too late-stage. Tregs represent one mechanism for syn-BMT-induced restoration of immune tolerance in STZ-diabetic mice.
answer:
yes
question:
Question: Is lipoprotein internalisation induced by oncogenic AMPK activation essential to maintain glioblastoma cell growth?
Answer: Our findings demonstrate that AMPK plays a crucial role in glioblastoma cell growth and suggest that blocking lipoprotein receptors could potentially be used as a plausible therapeutic approach for these and other type of tumours with high levels of AMPK.
answer:
yes
question:
Question: Is ischemic preconditioning cardioprotective in senescent human myocardium?
Answer: Our data indicate that ischemic preconditioning has no beneficial effect on the postischemic functional recovery of senescent human myocardium.
answer:
| no
| task846_pubmedqa_classification |
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Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Is autoimmune thyroiditis in children and adolescents with type 1 diabetes mellitus associated with elevated IgG4 but not with low vitamin D?
Answer: There was no difference of vitamin D levels between the groups. Only a small percentage of patients with type 1 diabetes also having autoimmune thyroiditis had elevated serum IgG4 levels, revealing the heterogeneity of autoimmune thyroiditis and existence of IgG4 thyroiditis in the pediatric age group. Total IgG, the other IgG subclasses, and vitamin D levels did not differ in patients with autoimmune thyroiditis and type 1 diabetes compared to those suffering only from type 1 diabetes.
Student: | yes | task846_pubmedqa_classification |
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You will be given a definition of a task first, then an example. Follow the example to solve a new instance of the task.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Why? The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
New input: Question: Do adiponectin levels predict clinical onset of type 1 diabetes in antibody-positive relatives?
Answer: Adiponectin levels do not contribute to the prediction of type 1 diabetes in Ab+ relatives.
Solution: | no | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
One example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution is here: yes
Explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Now, solve this: Question: Does co-Transplantation of Skin-Derived Precursors and Collagen Sponge facilitate Diabetic Wound Healing by Promoting Local Vascular Regeneration?
Answer: Accelerated wound healing and enhanced local capillary regeneration could be observed 14 days after skin ablation from both SKPs and collagen sponge co-transplanted and collagen sponge only groups. Subsequent analyses further revealed superior pro-angiogenic effects from the SKP and collagen sponge co-delivered group, which are mainly attributable to in vivo transdifferentation and paracrine signalling of the SKPs.
Solution: | yes | task846_pubmedqa_classification |
|
Definition: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Question: Is serum gamma-glutamyltransferase associated with subclinical atherosclerosis in patients with type 2 diabetes?
Answer: Serum GGT levels were significantly associated with obesity, atherogenic dyslipidaemia, and metabolic syndrome, but not with the early and late stages of atherosclerotic vascular changes, in patients with type 2 diabetes. Serum GGT level may not be a reliable marker of subclinical atherosclerosis in type 2 diabetes.
Output: | no | task846_pubmedqa_classification |
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Definition: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Question: Are variants of neurogenin 3 gene associated with Type II diabetes in Japanese subjects?
Answer: Mutations and polymorphisms of ngn3 gene are not significantly associated with Type II (non-insulin-dependent) diabetes mellitus in the Japanese subjects.
Output: | no | task846_pubmedqa_classification |
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Q: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does blockade of p38 mitogen-activated protein kinase pathway ameliorate delayed gastric emptying in streptozotocin-induced diabetic rats?
Answer: Inflammation was associated with the development of delayed gastric emptying, and blockade of p38 MAPK pathway with SB203580 ameliorates delayed gastric emptying in diabetic rats, at least in part, by inhibiting the expression of iNOS, TNF-a and IL-1β. Therefore, p38MAPK may serve as a novel target for the therapy of diabetes-related gastrointestinal dysmotility.
A: | yes | task846_pubmedqa_classification |
|
You will be given a definition of a task first, then an example. Follow the example to solve a new instance of the task.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Why? The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
New input: Question: Does mild-to-moderate intensity exercise improve cardiac autonomic drive in type 2 diabetes?
Answer: These data suggest that three times per week moderate intensity aerobic exercise for 6 months improves cardiac rhythm regulation as measured by heart rate variability in type 2 diabetic patients.
Solution: | yes | task846_pubmedqa_classification |
|
Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Question: Is short sleep duration associated with a blood pressure nondipping pattern in type 1 diabetes : the DIAPASOM study?
Answer: Dipping status in type 1 diabetes was associated with longer sleep duration and with hypoglycemia unawareness.
Output: | yes | task846_pubmedqa_classification |
|
Given the task definition and input, reply with output. Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Is low catalase activity in blood associated with the diabetes caused by alloxan?
Answer: These results indicate that low catalase activity in the blood is associated with the diabetes mellitus caused by alloxan administration.
| yes | task846_pubmedqa_classification |
|
instruction:
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
question:
Question: Does a null mutation in ANGPTL8 associate with either plasma glucose or type 2 diabetes in humans?
Answer: Disruption of ANGPTL8 function in humans does not seem to have a large effect on measures of glucose tolerance.
answer:
no
question:
Question: Are higher rates of viral suppression with nonnucleoside reverse transcriptase inhibitors compared to single protease inhibitors explained by better adherence?
Answer: A higher proportion of individuals using NNRTI-based regimens had viral suppression when compared to those taking single-PI-containing regimens, and this association was not confounded by higher levels of adherence. These results suggest that improved viral suppression on NNRTI regimens compared to single-PI regimens is more closely associated with regimen potency than higher levels of adherence.
answer:
no
question:
Question: Does sT depression in lead aVL differentiate inferior ST-elevation myocardial infarction from pericarditis?
Answer: When there is inferior ST-segment elevation, the presence of any ST depression in lead aVL is highly sensitive for coronary occlusion in inferior myocardial infarction and very specific for differentiating inferior myocardial infarction from pericarditis.
answer:
| yes
| task846_pubmedqa_classification |
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Q: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does stress and Coping predict Adjustment and Glycemic Control in Adolescents with Type 1 Diabetes?
Answer: The ways in which adolescents with type 1 diabetes cope with diabetes-related stress predict quality of life and symptoms of depression but not glycemic control. Through the use of screening to identify adolescent's diabetes-related stress and targeted interventions to improve coping strategies, there is potential to improve outcomes.
A: | yes | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
[EX Q]: Question: Are leg muscle reflexes mediated by cutaneous A-beta fibres normal during gait in reflex sympathetic dystrophy?
Answer: In the acute phase of RSD of the lower extremity there is no evidence for abnormal A-beta fibre-mediated reflexes or for defective regulation of such reflexes. This finding has implications for both the theory on RSD pathophysiology and RSD models, which are based on abnormal functioning of A-beta fibres.
[EX A]: yes
[EX Q]: Question: Are decreased plasma levels of select very long chain ceramide species associated with the development of nephropathy in type 1 diabetes?
Answer: These studies demonstrate, prospectively, that decreased plasma levels of select ceramide species are associated with the development of macroalbuminuria in type 1 diabetes.
[EX A]: yes
[EX Q]: Question: Does differential proteomic analysis of grapevine leave by iTRAQ reveals responses to heat stress and subsequent recovery?
Answer: On the basis of these findings, we proposed that some proteins related to electron transport chain of photosynthesis, antioxidant enzymes, HSPs and other stress response proteins, and glycolysis may play key roles in enhancing grapevine adaptation to and recovery capacity from heat stress. These results provide a better understanding of the proteins involved in, and mechanisms of thermotolerance in grapevines.
[EX A]: | yes
| task846_pubmedqa_classification |
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Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Is the high prevalence of autoantibodies to tissue transglutaminase in first-degree relatives of patients with type 1 diabetes associated with islet autoimmunity?
Answer: We found a high prevalence of celiac autoimmunity in patients and first-degree relatives of children with type 1 diabetes, but we found limited overlap between islet and celiac autoimmunity in nondiabetic relatives. The high prevalence of celiac autoimmunity may be explained by shared genetic susceptibility and identifies a population within which screening for the disease may be justified.
Student: | no | task846_pubmedqa_classification |
|
Teacher: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? If you are still confused, see the following example:
Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Reason: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Now, solve this instance: Question: Does diabetes influence oral oncogenesis through fibroblast growth factor receptors?
Answer: It seems that diabetes does not affect the FGFR-2 and FGFR-3 pattern of expression throughout the various stages of oral oncogenesis.
Student: | no | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Let me give you an example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
The answer to this example can be: yes
Here is why: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
OK. solve this:
Question: Does deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice?
Answer: These results demonstrate that G6pc2 is an important driver for the selection and expansion of islet-reactive CD8(+) T cells infiltrating NOD/ShiLtJ islets. However, autoreactivity to G6pc2 is not essential for the emergence of autoimmune diabetes. The results remain consistent with previous studies indicating that insulin may be the primary autoimmune target, at least in NOD/ShiLtJ mice.
Answer: | no | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Are filaggrin loss-of-function mutations a predisposing factor for atopic dermatitis in an Ishigaki Island under subtropical climate?
Answer: The FLG loss-of-function mutation frequency was not significantly different between the AD and non-AD groups in a cohort of children from Ishigaki Island, which has a subtropical climate, suggesting that FLG loss-of-function mutations are not always a predisposing factor for AD prevalence.
no
Question: Does pharmacological preconditioning using intraportal infusion of L-arginine protect against hepatic ischemia reperfusion injury?
Answer: Pharmacological preconditioning with intraportal L-arginine provided protection against hepatic I/RI in early phases of the reperfusion period. The mechanisms underlying the protective effect may include preservation of the mitochondrial structure and inhibition of caspase-3 activity.
yes
Question: Do adiponectin levels predict clinical onset of type 1 diabetes in antibody-positive relatives?
Answer: Adiponectin levels do not contribute to the prediction of type 1 diabetes in Ab+ relatives.
| no
| task846_pubmedqa_classification |
|
Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Does autophagy protect human podocytes from high glucose-induced injury by preventing insulin resistance?
Answer: The presence or activation of autophagy was found to play a protective role in human podocytes against high glucose-induced insulin resistance and cell injury, which indicates a novel cellular mechanism and provides a potential therapeutic target for diabetic nephropathy (DN).
Student: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Let me give you an example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
The answer to this example can be: yes
Here is why: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
OK. solve this:
Question: Is duration of obesity a risk factor for type 2 diabetes mellitus , arterial hypertension and hyperlipidemia?
Answer: The duration of obesity, as reported by women presenting for treatment of obesity, is not a risk factor for type 2 DM, HT and HL.
Answer: | no | task846_pubmedqa_classification |
|
Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Problem:Question: Is increased urine semaphorin-3A associated with renal damage in hypertensive patients with chronic kidney disease : a nested case-control study?
Answer: USEMA is independently associated with CKD in both diabetic and non diabetic hypertensive patients. Further studies may help clarify the mechanisms underlying this association and possibly the pathogenic changes leading to the development of CKD.
Solution: | yes | task846_pubmedqa_classification |
|
Teacher: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? If you are still confused, see the following example:
Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution: yes
Reason: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Now, solve this instance: Question: Is whole-body heat loss during exercise in the heat impaired in type 1 diabetes?
Answer: During light-to-moderate-intensity exercise performed under conditions permitting full sweat evaporation, otherwise healthy type 1 diabetic individuals did not show impaired heat loss responses during heat exposure when compared with matched individuals without diabetes.
Student: | no | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
One example is below.
Q: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
A: yes
Rationale: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Q: Question: Does blocking ET-1 receptors correct subnormal retinal oxygenation response in experimental diabetic retinopathy?
Answer: Because subnormal retinal DeltaPo(2) after drug treatment is a biomarker of subsequent vascular histopathology, the present data raise the possibility that retinal ET-1 does not play a key role in the pathogenesis of diabetic retinopathy.
A: | no | task846_pubmedqa_classification |
|
TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Is pre-surgical cortical activation to food pictures associated with weight loss following bariatric surgery?
Answer: We found that neural activity in previously established regions associated with cognitive and behavioral self-regulation predicts weight loss following bariatric surgery. These preliminary findings highlight the role of neural circuitry in the success and maintenance of weight loss and suggest a possible future use of fMRI in screening LAGB surgery candidates.
SOLUTION: yes
PROBLEM: Question: Is dorsal plication without degloving safe and effective for correcting ventral penile deformities?
Answer: Penile plication is a safe and effective technique for correcting all directions of curvature. Dorsal plication without degloving produces favorable objective and subjective results comparable to ventral and lateral plication.
SOLUTION: yes
PROBLEM: Question: Is duration of obesity a risk factor for type 2 diabetes mellitus , arterial hypertension and hyperlipidemia?
Answer: The duration of obesity, as reported by women presenting for treatment of obesity, is not a risk factor for type 2 DM, HT and HL.
SOLUTION: | no
| task846_pubmedqa_classification |
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TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Is cytosine deamination a major cause of baseline noise in next-generation sequencing?
Answer: Baseline noise during NGS is mostly due to cytosine deamination, the source of which is likely to be both biologic and an artifact of thermocycling, and it can be reduced by UNG pretreatment.
SOLUTION: yes
PROBLEM: Question: Do extremely cold and hot temperatures increase the risk of diabetes mortality in metropolitan areas of two Chinese cities?
Answer: The results indicate that both extremely cold and hot temperatures increase diabetes mortality in different manners in Harbin and Chongqing. Diabetes education programs should include information on either managing or combating the effects of extreme hot and cold weather.
SOLUTION: yes
PROBLEM: Question: Does sTAT3beta interfere with granulocyte colony-stimulating factor-induced neutrophilic differentiation?
Answer: These findings argue against a role of STAT3beta as a negative regulator of G-CSF-induced expression of p27 and myeloid differentiation.
SOLUTION: | no
| task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Does converging evidence implicate the abnormal microRNA system in schizophrenia?
Answer: Collectively, results from all 3 lines of evidence, suggest that the genetically based dysregulation of miRNA systems undermines miRNAs' inhibitory effects, resulting in the abnormal upregulation of genome transcription in the development of SZ.
A: yes
****
Q: Question: Does diabetes influence oral oncogenesis through fibroblast growth factor receptors?
Answer: It seems that diabetes does not affect the FGFR-2 and FGFR-3 pattern of expression throughout the various stages of oral oncogenesis.
A: no
****
Q: Question: Does periodontitis promote the diabetic development of obese rat via miR-147 induced classical macrophage activation?
Answer: This study provided new evidence for the positive effect of periodontal inflammation on diabetic development, while the regulatory mechanism of miR-147 on classical macrophage activation, was verified, and presumed to contribute to the impaired glucose tolerance aggravated by periodontitis in obese rats. Besides, this study indicated the application of miR-147 for therapeutic approach in the treatment of diabetes with periodontitis.
A: | yes
****
| task846_pubmedqa_classification |
|
Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Problem:Question: Does naked plasmid-mediated gene transfer to skeletal muscle ameliorate diabetes mellitus?
Answer: Skeletal muscle is a potentially useful platform for ectopic secretion of insulin using naked plasmid as a gene transfer vector. Injection at two sites 14 days before the onset of severe hyperglycemia is optimal. This approach could protect Type I diabetics from fatal ketoacidosis and enhance the action of agents that sensitize tissues to insulin in type II diabetes.
Solution: | yes | task846_pubmedqa_classification |
|
Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Does metformin reduce circulating malondialdehyde-modified low-density lipoprotein in type 2 diabetes mellitus?
Answer: These results suggest that increasing the dose of metformin improves serum MDA-LDL levels in type 2 diabetes mellitus.
A: | yes | task846_pubmedqa_classification |
|
Definition: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Question: Does collaborative DTM reduce hospitalization and healthcare costs in patients with diabetes treated with polypharmacy?
Answer: A collaborative pharmacist-driven DTM program with a care manager-executed patient outreach component results in reduced hospital utilization and significant healthcare cost savings.
Output: | yes | task846_pubmedqa_classification |
|
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
--------
Question: Question: Does co-Transplantation of Skin-Derived Precursors and Collagen Sponge facilitate Diabetic Wound Healing by Promoting Local Vascular Regeneration?
Answer: Accelerated wound healing and enhanced local capillary regeneration could be observed 14 days after skin ablation from both SKPs and collagen sponge co-transplanted and collagen sponge only groups. Subsequent analyses further revealed superior pro-angiogenic effects from the SKP and collagen sponge co-delivered group, which are mainly attributable to in vivo transdifferentation and paracrine signalling of the SKPs.
Answer: yes
Question: Question: Does classical swine fever virus induce oxidative stress in swine umbilical vein endothelial cells?
Answer: Our results indicated that CSFV infection induced oxidative stress in SUVECs. These findings provide novel information on the mechanism by which CSFV can alter intracellular events associated with the viral infection.
Answer: yes
Question: Question: Is increased insulin-like growth factor 1 production by human osteoarthritic chondrocytes dependent on growth hormone action?
Answer: This study indicates that the elevated synthesis of IGF-1 by adult human OA chondrocytes occurs through a GH/GHR-independent mechanism, suggesting that other factors are capable of controlling local IGF-1 production in these cells.
Answer: | no
| task846_pubmedqa_classification |
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instruction:
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
question:
Question: Does oligofructose affect the development of type 1 diabetes mellitus induced by dietary proteins in the diabetes-prone BB rat model?
Answer: In the BB rat model, 5% OF in the diet did not have any protective effects against diet-induced T1DM. The present data do not suggest dietary OF as a promising approach for the dietary prevention of T1DM.
answer:
no
question:
Question: Is cytosine deamination a major cause of baseline noise in next-generation sequencing?
Answer: Baseline noise during NGS is mostly due to cytosine deamination, the source of which is likely to be both biologic and an artifact of thermocycling, and it can be reduced by UNG pretreatment.
answer:
yes
question:
Question: Are health promotion lifestyle profile scores associatedwith obesity in high school students?
Answer: Adolescence is an era of development when individuals start to implement their own features to life. According to this study adolescents do not perform health promoting lifestyles whether they are obese or not.
answer:
| no
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Example solution: yes
Example explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Problem: Question: Are prepregnancy body mass index and prenatal fasting glucose effective predictors of early postpartum metabolic syndrome in Spanish mothers with gestational diabetes?
Answer: Women having GDM are at threat of early postpartum metabolic syndrome. This risk can be easily identified by assessing prepregnancy BMI and antenatal fasting glycemia in the first pregnancy visit.
| Solution: yes | task846_pubmedqa_classification |
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Given the task definition, example input & output, solve the new input case.
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Output: yes
The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
New input case for you: Question: Are diabetes and increased lipid peroxidation associated with systemic inflammation even in well-controlled patients?
Answer: These findings show that dyslipidemia is associated with an increased inflammatory status, even in well-controlled diabetics and in normoglycemics. Our results suggest that lipid metabolism and peroxidation are important for the development of inflammation, which is elevated in several complications associated with diabetes.
Output: | yes | task846_pubmedqa_classification |
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Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Question: Is hepatic steatosis prevalent in stillborns delivered to women with diabetes mellitus?
Answer: This study is the first to our knowledge to demonstrate a specific association between fetal hepatic steatosis and maternal diabetes.
Output: | yes | task846_pubmedqa_classification |
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Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Problem:Question: Does vitamin D 20,000 IU per Week for Five Years Prevent Progression From Prediabetes to Diabetes?
Answer: In subjects without vitamin D deficiency, vitamin D supplementation is unlikely to prevent progression from prediabetes to diabetes. Very large studies with inclusion of vitamin D-deficient subjects will probably be needed to show such a putative effect. This study tested if supplementation with vitamin D to subjects with prediabetes will prevent progression to type 2 diabetes (T2DM).
Solution: | no | task846_pubmedqa_classification |
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
One example: Question: Are group 2 innate lymphoid cells ( ILC2s ) increased in chronic rhinosinusitis with nasal polyps or eosinophilia?
Answer: As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insights into its pathogenesis.
Solution is here: yes
Explanation: The answer clearly says that ICLSs are elevated, which is exactly what the question asks. Hence, the output will be yes and it is correct.
Now, solve this: Question: Is regular Chinese Green Tea Consumption Protective for Diabetic Retinopathy : A Clinic-Based Case-Control Study?
Answer: Diabetic patients who had regularly drunk Chinese green tea every week for at least one year in their lives had a DR risk reduction of about 50% compared with those who had not. Regular Chinese green tea consumption may be a novel approach for the prevention of DR.
Solution: | yes | task846_pubmedqa_classification |
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TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Do xenon and nitrous oxide depress cardiac function in an isolated rat heart model?
Answer: Our data suggest that cardiac contractility was decreased by the effects of reduced O2 delivery, but both Xe and N2O did not cause further cardiac depressant effects compared to N2 in this experimental model.
SOLUTION: no
PROBLEM: Question: Does a null mutation in ANGPTL8 associate with either plasma glucose or type 2 diabetes in humans?
Answer: Disruption of ANGPTL8 function in humans does not seem to have a large effect on measures of glucose tolerance.
SOLUTION: no
PROBLEM: Question: Are asymptomatic ventricular premature depolarizations necessarily benign?
Answer: The absence of typical VPD-related symptoms may be a risk factor for cardiomyopathy and be associated with an adverse outcome.
SOLUTION: | no
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Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Question: Does pluronic L-81 ameliorate diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein?
Answer: L-81 represents a promising candidate in the development of a selective insulin-mimetic molecule and an anti-diabetic agent. | yes | task846_pubmedqa_classification |
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Teacher:Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Teacher: Now, understand the problem? Solve this instance: Question: Does the phospholipase A ( 2 ) inhibitor methyl indoxam suppress diet-induced obesity and glucose intolerance in mice?
Answer: These results show that oral supplementation of a diabetogenic diet with the Pla2g1b inhibitor methyl indoxam effectively suppresses diet-induced obesity and diabetes in mice. This suggests that Pla2g1b inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes.
Student: | yes | task846_pubmedqa_classification |
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