Study_ID
string | Objectives
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CRD420250653700 | To evaluate the effectiveness of these technologies in supporting children's mental health. | No Published between 2020 to 2024 Publications in scientific articles Publications in English Related to the field of study Published between 2020 to 2024 Publications in scientific articles Publications in English Related to the field of study | Published outside the established time interval. Published in a format other than a scientific article (congress, thesis, etc.) Published in a language other than English Research not related to the field of study. Published outside the established time interval. Published in a format other than a scientific article (congress, thesis, etc.) Published in a language other than English Research not related to the field of study. |
CRD42021239131 | A population of youth with mental health problems do not fit any specific DSM diagnosis or they fit many over time. This population experiences severe and enduring mental health problems (SEMHP), while cannot be identified by current diagnostics. A definition has been emerged [5] for persons with severe psychiatric disorders (see 19). However, although this definition is based on a large sample size, the sample mainly consists of adults. Therefore, the description is limited in its application to youth. While, youth could experience a psychiatric disorder that requires care with severe disabilities in social functioning, this could manifest itself in a completely different way than in adults [10]. The definition could be used as a starting point, but the meaning of severe mental health problems and enduring mental health problems of youth needs to be explored. The understanding of youth with SEMHP requires further insight in the characteristics of these youth and the factors that might contribute to the development and continuation of SEMHP (see 23). The main objective of this review is to identify key features of SEMHP in youth.This is converted to four research questions:
1. In what manner is there (in the existing literature) referred to severe and enduring mental health problems in youth?
2. What is known about the concepts associated with SEMHP?
3. What is known about the nature of problems developing in SEMHP?
3.1 What is known about associated biopsychosocial factors with SEMHP in youth?
4. What is known about the impact of SEMHP on youth? | The conditions that will be studied will be Severe and Enduring Mental Health Problems in Youth. The domains that will be studied are the biopsychosocial factors and the impact of severe and enduring mental health problems. | null |
CRD42022311367 | Is high residential mobility associated with poorer child outcomes, cognition, or physical and mental health in Indigenous children from Australia, Canada and New Zealand? | Child outcomes including: physical health, mental health and wellbeing, social and emotional wellbeing, cognitive development, behavioral development and academic outcomes. | null |
CRD420250614560 | To estimate the pooled prevalence of depression and anxiety among people with disabilities. | Depression and anxiety among people with disabilities. - People with disabilities, with disability defined by the International Classification of Functioning, Disability, and Health Model and the UN Convention on the Rights of Persons with Disabilities (this includes people with specific conditions deemed likely to result in disability [eg, spina bifida and schizophrenia], specific impairments [eg, visual, hearing, and physical impairments], and disability measured through functioning, activity limitations, or self-report [eg, Washington Group questions and activities of daily living]), no quantitative duration of disability is required. - All age and any sex. - Disability, as defined under Population. A comparator is not necessary, and both comparative and non-comparative studies will be included. | - Some measures of disability will not eligible, including mild functional impairment (e.g., visual acuity ≥20/40, Washington group questions that reported some difficulty or less, only one functional limitation in activities of daily life), frailty alone, and disability as a continuous measure. - Studies where disability is defined as depression/anxiety alone (e.g. via Washing Group questions) will be excluded. - Although dementia would meet the definition of disability, we will exclude studies on dementia alone, given the association between pseudo-dementia and depression, and the difficulty deriving accurate prevalence estimates for this population. Pseudo-dementia refers to symptoms that mimic those of dementia but have other underlying causes, which is often depression. |
CRD420250550245 | Does Access to Intimate Relationships lead to positive outcomes for Inpatient Forensic Mental Health Populations? Does Access to Intimate Relationships affect mental health outcomes for Inpatient Forensic Mental Health Populations? Does Access to Intimate Relationships affect wellbeing among Inpatient Forensic Mental Health Populations? Does Access to Intimate Relationships lead to negative outcomes for Inpatient Forensic Mental Health Populations? Do Inpatient Forensic Mental Health Populations who have access to intimate relationships present a higher level of risk? | Well-being; Inpatient Care Health and wellbeing of inpatient forensic mental health patients. Forensic Inpatient Mental Health Populations. To include literature relating to a general adult human population. To include forensic unit or secure setting inpatient populations. The intervention is permitted access to intimate relationships with consenting partners.To include access to physical intimacy (ranging from holding hands to sexual intercourse) with a consenting partner. This can also include unsupervised phone or videocalls with the ability to engage in sexual activity privately. The comparator or control will be inpatient forensic mental health populations who do not have access to physical or virtual intimacy with a consenting partner. | To exclude literature involving community-based patients or prisoners. To exclude populations that have additional capacity to consent concerns e.g. inpatients under the age of 18 or inpatients with a diagnosis of intellectual disability. To exclude lone sexual practices such as masturbation or the use of pornographic material. |
CRD42023438620 | Are smartphone applications designed for managing mental health conditions effective at improving mental health symptoms? | Mental Health including but not limited to depression, anxiety, stress management, bipolar disorder, post-traumatic stress disorders (PTSD), substance use disorders, sleep disorders, and suicidal behaviors. Well-being is also included. | null |
CRD42023460718 | The overall aim of this umbrella review is to provide a comprehensive understanding of mental health stigma reduction interventions that are facilitated within industry settings. This umbrella review will address the following research questions:1) What is the quality of reviews published in this area?2) What industry mental health stigma reduction intervention approaches are the most effective at reducing stigma?3) In which workplaces/industries are these interventions most effective?4) How effective are these industry mental health stigma reduction interventions at maintaining changes in stigma over time? | This umbrella review will investigate mental health stigma. Poor mental health/mental health problems will be defined as any mental health disorder listed in the DSM-5-TR.Stigma will be defined as any discrediting characteristic or attribute for which a person is seen as different from others in a way that is dangerous, weak, or generally less desirable. This includes any form of stigma or discrimination; including social/public stigma, perceived stigma, self/internal stigma, professional/health practitioner stigma, institutional stigma, anticipated stigma, stigma by association/family stigma, and label avoidance stigma. The population of this umbrella review are participants who:INCLUDE:- Staff of any business or organisation within any industry- Paid or unpaid staff- Entry level to executive staff- Staff of educational institutions- Staff of mental health businesses and organisations- Labour hire or individual contractors working for a business or organisation at the time of interventionEXCLUDE:- Self-employed individuals (businesses or organisations with only one staff member)- Students of educational institutions - Clients and customers of any business or organisation- Participants who are not working at the time of intervention (e.g. retired, on leave, job seekers) The interventions being investigated in this umbrella review are mental health stigma reduction interventions. Mental health stigma reduction interventions will be defined as any intervention, program or initiative that aims to reduce stigma towards mental ill health.INCLUDE:- Any mental health stigma reduction intervention approach (e.g. education/contact promotion interventions)- Interventions to reduce mental health stigma generally- Interventions to reduce stigma towards specific mental health disorders- Online or face-to-faceEXCLUDE:- Interventions to specifically improve staff wellbeing- Interventions to specifically improve staff mental health This umbrella review will include reviews with and without control groups. Ideally, there should be at least one baseline (pre-intervention) and one post-intervention measurement which are compared. However, studies with only one post-intervention measurement will still be considered where appropriate. | null |
CRD420250643420 | What is the effectiveness of physical exercise interventions incorporating VR/AR technology compared to usual care in improving mental health outcomes, adherence, and user experience among patients with mental disorders. | Any mental disorder (e.g., depression, anxiety, schizophrenia, bipolar disorder, cognitive impairments and organic mood disorder) according to DSM-5, ICD-10, or equivalent criteria. Individuals of any age diagnosed with any mental disorder (e.g., depression, anxiety, schizophrenia, bipolar disorder, cognitive impairments and organic mood disorder) according to DSM-5, ICD-10, or equivalent criteria. Physical exercise programs that use VR or AR technology (e.g., VR gaming-based exercise, AR fitness apps). Usual care, including traditional physical exercise, standard pharmacological or psychological treatments, or no intervention. | null |
CRD420250649002 | General Objective | Ergonomic Education; Nutrition education; Musculoskeletal injury; Physical Exercises; Quality of Life; General Pathology; Emotional State Research areas related to military firefighters: Psycho-emotional; Pathologies; Quality of life and physical exercise; Musculoskeletal injury, nutrition and ergonomics at work. Brazilian Fire Fighter Inclusion criteria:I. sample composed exclusively of Brazilian firefighters, men and/or women;II. original articles published in English, Portuguese or Spanish;III. publications made between 2000 and 2025;IV. publications related to pathologies, the psycho-emotional area, quality of life and physical exercise, as well as musculoskeletal injuries, nutrition and ergonomics at work. All scientific articles related to the indicated topics and military firefightersThe production of research on scientific publications that encompass content related to pathologies, the psycho-emotional area, quality of life and physical exercises, as well as musculoskeletal injuries, nutrition and ergonomics in the work of military firefighters are relevant, as they can be used as a guiding principle for planning actions and implementation of institutional tools aimed at improving the quality of life of these professionals. None | Exclusion Criteria: I. studies repeated in the databases and/or duplicates in both searches; II. systematic literature reviews; III. case reports; IV. articles without full access; V. studies compiled from conferences or not completed; VI. theses, dissertations and book chapters. |
CRD42025630772 | What is the effectiveness of psychosocial interventions in reducing symptoms of psychological trauma as a result of war, among forcibly displaced children in the SWANA region? | For the purposes of this systematic review, forcibly displaced children will be made up of refugees, internally displaced persons and asylum seekers.
The condition being studied in this review is symptoms of psychological trauma in forcibly displaced children from the SWANA (Southwest Asia and North Africa) region. These children often experience high levels of psychological distress due to exposure to war, violence, displacement, and loss. Common health outcomes include various symptoms relevant to Post-Traumatic Stress Disorder (PTSD), anxiety, depression, and other trauma-related symptoms, some of which are irritability, restlessness, sleep problems, somatic symptoms and conduct disorders which significantly impact their mental health and overall well-being.
The review focuses on evaluating the effectiveness of psychosocial interventions in reducing these symptoms. | null |
CRD42024505349 | We intend to review empirical studies investigating relationships between religiosity, spirituality, and suicidal ideation and behavior in adolescents. | The condition being studied encompasses suicidal ideation, suicide planning, suicide attempts, and completed suicides. | null |
CRD42022364626 | What is the available evidence surrounding post-partum depression in intended parents, adoptive parents, trans-parents and fathers?
Objectives are to:
(1) Collate all the available evidence surround post-partum depression in intended parents, adoptive parents, trans-parents and fathers.
(2) Determine causes, healthcare outcomes and available interventions of PPD in the aforementioned patient groups
(3) Identify the gaps in research surrounding PPD in these groups and provide recommendations for future research. | Post-partum depression (PPD) is widely studied in the birthing parent due to the drastic effects it can have on their functional abilities and long term health outcomes. The aetiology of post-partum depression is largely credited to the biological and psychological drivers of pregnancy and childbirth. Intended parents, adoptive parents, trans-parents and fathers belong to a community where pregnancy and childbirth is not directly experienced and a potentially higher risk of PPD is associated with these groups. The exact cause is unclear but the psychosocial factors attached to being a parent, regardless of parental status, could play a much larger role in the aetiology of PPD than previously anticipated. Furthermore, the current practices and interventions aimed at alleviating symptoms of PPD are wholly focused on the birthing parent, with very few providing targeted support to these four patient groups. This review will aim to collate all the available evidence surrounding PPD in the aforementioned patient groups and identify the clear gaps in research. These findings can ultimately determine what precipitates the mental health condition in these groups and whether it is feasible for future evidence-based practices to include such groups in their tailored management approaches for PPD. | null |
CRD42024629311 | What were the risk and protective factors that were associated with mental health outcomes during pandemics and epidemics in different population groups? Furthermore, how do the effects of those factors vary between the general population and specific subgroups such as healthcare workers, vulnerable individuals (e.g., older adults, chronically ill), and young people? What characteristics at the level of study design, participant characteristics and contexts impacted the effects of these risk and protective factors on mental health outcomes during pandemics and epidemics? | Mental health in times of pandemic-or epidemic-related adversities. We will study the trajectories of negative and positive mental health following pandemic/epidemic-related stressor exposure as well as risk and protective factors. | null |
CRD42024611777 | For the systematic review titled "A Systematic Review and Meta-Analysis on the Influence of Exercise-Induced Oxidative Stress on the Pathogenesis of Infectious Diseases," appropriate review questions could be framed as follows:
Does exercise-induced oxidative stress contribute to the development or progression of infectious diseases?
What specific mechanisms are involved in the relationship between oxidative stress from exercise and infectious disease pathogenesis?
Are there particular types of exercise or intensities that are associated with higher levels of oxidative stress and increased risk of infectious diseases?
How do individual factors, such as age, baseline health, or training level, modify the relationship between exercise-induced oxidative stress and susceptibility to infectious diseases?
These questions can be structured or refined using the PI(E)COS framework, where relevant:
Population (P): Individuals of varying ages, health statuses, and exercise backgrounds.
Intervention (I): Different types and intensities of exercise.
Comparator (C): Control groups with no exercise or different exercise intensities.
Outcome (O): Incidence, severity, or progression of infectious diseases.
(E) Exposure: Exercise-induced oxidative stress.
Study Design (S): Studies suitable for systematic review and meta-analysis, such as randomized controlled trials, cohort studies, or observational studies. | This systematic review and meta-analysis investigates the influence of exercise-induced oxidative stress on the pathogenesis of infectious diseases. Oxidative stress, a condition marked by an imbalance between free radicals and antioxidants in the body, can be triggered by high-intensity or prolonged physical exercise. While moderate exercise is known to strengthen immune defenses, intense or exhaustive exercise can lead to increased oxidative stress, potentially weakening the immune response. This imbalance may make the body more susceptible to infections or influence the severity and progression of infectious diseases.
The review aims to understand how different intensities and types of exercise impact oxidative stress levels and, consequently, immune function in relation to infectious diseases. This research domain is relevant to healthcare fields focusing on sports medicine, infectious disease management, and preventive medicine. By examining existing studies, this review seeks to provide a comprehensive understanding of the mechanisms connecting exercise-induced oxidative stress to infectious disease susceptibility and progression. It also aims to identify which factors—such as exercise type, duration, and individual characteristics like age or baseline health—play a significant role in modulating this relationship. This knowledge could guide recommendations for safe exercise practices that support immune health without increasing infection risk. | null |
CRD420250623406 | Exploring risk factors affecting malnutrition in patients with diabetic feet | Patients with diabetes foot Patient with Diabetic Foot Condition Malnutrition Normal nutrition | null |
CRD420250651110 | Is there any positive effect of strength training on cognitive domains such as working memory, attention, language, global cognition, executive function, and reaction time in middle-aged and older individuals? | ue to the fact that the sample includes only healthy individuals, with any pathology being an exclusion criterion, there is no disease to be described. However, it is worth considering the physiological decline of cognitive domains that accompanies senescence as an existing factor, although not relevant to the scope of this study. A total of 331 patients were involved, and after data interpretation, the inclusion criteria were individuals over 45 years old, free from any medical conditions, independent in society, and undergoing strength training. Articles that were unclear or confusing regarding the methodology and results were excluded. The interventions or exposures to be analyzed include systematic strength exercises performed on machines, high-velocity strength training, strength exercises with progressive load increase, and lower-limb strength exercises with and without instability. Studies that do not include individuals undergoing strength training in at least one of the analyzed groups or that are unclear or confusing regarding the methodology and results presented will be excluded from the scope of this review. For the scope of this review, studies comparing the experimental group (undergoing strength training) with a control group, an aerobic exercise group, a treadmill training group, an active control training group (“balance-and-tone training”), a free-weight resistance training group with physical instability and mentally challenging conditions, a machine-based resistance training group, and a group engaged in reading materials related to exercise and mental health will be considered. | Individuals below middle age (under 44 years old). |
CRD42023485414 | Do patients feeling stress identified by screening in primary care benefit from a social prescription when compared with conventional care? | Stress | null |
CRD42025635805 | To conduct a comprehensive review of existing psychological-cognitive assessment and support guidelines for cancer patients and their families across the EU. | We explored the existing psychological-cognitive assessment and support guidelines for cancer patients and their families across the EU. | null |
CRD420250645870 | Study of the prevalence of various sleep disorders (insomnia, sleep apnea, parasomnia, restless legs syndrome, narcolepsy, etc.) in infertile women | infertility is defined as the inability to conceive after one or two years of unprotected intercourse . In recent years, we have witnessed an increase in the rate of infertility in different parts of the world. Infertile people experience various problems at the individual, family and social levels. Infertility can cause changes in quality of life because it can cause changes in the standard of living and cause personal, family, and social problems.The stress of infertility can affect sleep patterns by affecting quality of life. Sleep disorders include problems with the quality, timing, and amount of sleep that lead to daytime distress and impaired functioning. Sleep-wake disorders often occur with medical or other mental health conditions, such as depression, anxiety, or cognitive impairment .Considering the prevalence of infertility in Iran and the national policies announced as an upstream document regarding the issue of the youth of the population, this study will be conducted with the aim of investigating the prevalence of sleep disorders in infertility in the form of a systematic review study to examine the problems related to the field of sleep disorders in infertility and, based on those problems, appropriate interventions to improve them can be designed and implemented. Inclusion and exclusion criteria:The inclusion criteria included reporting sleep disorders in infertile individuals (lack of pregnancy after one year of intercourse without using contraception), using a standard tool (valid and reliable) to assess sleep disorders, cross-sectional studies or longitudinal data. Outcome measures:To investigate the prevalence or mean score of sleep disorders in infertile individuals (women or men or couples) reported by standard instruments (valid and reliable questionnaires or clinical interviews) in studies. Not applicable. | The exclusion criteria included articles on mental and physical illness, lack of access to full-text articles, non-English language studies, systematic studies and meta-analyses, case reports, and animal studies. |
CRD42021277626 | 1. What is the prevalence of (i) chronic work stress and (ii) occupational burnout among general surgery residents training in Accreditation Council for Graduate Medical Education (ACGME)-affiliated programs?
2. What antecedent factors significantly influence the development of (i) chronic work stress and (ii) occupational burnout among general surgery residents?
3. What is the quantitative association of (i) chronic stress and/or (ii) occupational burnout with the (iii) physical/mental health and (iv) clinical performance of surgery residents? | The effects of chronic stress and/or burnout on the personal health and clinical work performance of general surgery residents. | null |
CRD42020164487 | To compare the efficacy of different repetitive transcranial magnetic stimulation (rTMS) protocols
for the treatment of Obsessive-Compulsive Disorder (OCD) using network meta-analysis approach. | Obsessive-compulsive disorder (OCD) is a chronic and debilitating psychiatric disorder with a lifetime
prevalence of 2.3 %.
Current first-line treatments for OCD include selective serotonin reuptake inhibitors (SSRIs) or
cognitive-behavioural therapy (CBT). However, 40–60% of OCD patients fails to respond to
medication, or is unable to tolerate medication side effects.
For these reasons, alternatives to classical therapies would be very helpful, and neuromodulation
techniques offer very promising perspectives for OCD treatment, as they do for depression.
As a non-invasive technique, repetitive transcranial magnetic stimulation (rTMS) has been explored
in several clinical trials with various targets and stimulation protocols.
Several randomized control trials using repeated transcranial magnetic stimulation (rTMS) to treat
OCD have been published since 1997, but their results are inconclusive. The differences in results
may be due to their use of different rTMS protocols or the inclusion of patients with different
characteristics.
Due to conflicting and uncertain results, and in the absence of other effective rTMS targets to treat
OCD patients, it seems important to obtain more conclusive information about the efficacy of rTMS
with respect to protocols and cortical targets used. Due to lack of head to head trials of different targets used finding indirect evidence through Network Meta-Analysis could be of value in instating treatment protocols. | null |
CRD42020199982 | The primary aim is to examine the effectiveness of cognitive-behavioral therapies targeting mental health problems for Asian American youth. | Youth mental health problems related to one or more disorders in the DSM-5, such as depression, anxiety, behavior problems, and eating disorders, were studied. | null |
CRD42020212531 | This study aim is to evaluate the diagnostic accuracy the five standard molecular panels Thyroseq Next Generation Sequencing panel (NGS), Afirma Gene Expression Classifier (GEC) or Gene Sequencing Classifier (GSC), RosettaGX Reveal, ThygeNEXT/ ThyraMIR, ThygenX/ThyraMIR for cytologically indeterminate thyroid nodules using network meta-analysis method. | The diagnosis of indeterminate lesions of the thyroid is a challenge in cytopathology practice, leading to potentially unnecessary surgery in patients for whom final histology is benign. Indeed, up to 30% of cases lack the morphological features needed to provide definitive classification. The first studies dealing with the preoperative molecular evaluation of fine-needle aspiration biopsy (FNAB) samples focused on the analysis of the BRAFV600E mutation or the combined evaluation of two or three genetic alterations. The sensitivity of molecular testing was then improved by introducing molecular panels, which became available for clinical use in the late 2000s.
Two different categories of molecular panels have been developed, the 'rule-out' methods, which aim to reduce the avoidable treatment of benign nodules, and the 'rule-in' tests that have the purpose of optimizing surgical management. Validation studies of both the Afirma GEC and Thyroseq panel are ongoing. Recent additions to available molecular testing for indeterminate thyroid nodules include the Rosetta microRNA classifier and the augmentation of the ThyGenX gene panel with a microRNA reflex test (ThyraMIR).
The genetic evaluation of indeterminate thyroid nodules is predicted to improve patient care, mainly if molecular tests are used appropriately and aware of their advantages and weaknesses. | null |
CRD42021298311 | The objective of this systematic review and meta-analysis is to provide a comprehensive review of the impact of COVID-19 infection (i.e., severe and mild/recovery phases of COVID-19) on pediatric brain structure and function. | Neuroimaging biomarkers of COVID-19 patients (via brain PET and MRI analysis) who showed neurological manifestations. | null |
CRD42021236725 | What are the sociodemographic correlates and risk factors of cannabis vaping? | With increasing jurisdictions adopting cannabis legalisation, there is a change in social acceptability towards cannabis and the patterns of cannabis consumption. The potency of cannabis products has increased in recent years due to an increase in demand to achieve greater psychoactive effects. Cannabis had mainly been smoked, but the proliferation of cannabis products with higher THC content (e.g. cannabis oil, concentrates or extracts – wax and shatters) and cannabis vaporisers (including e-cigarettes) have led to a new method of consuming cannabis - vaping. People that use cannabis can now heat cannabis to release the psychoactive compounds into vapour that is inhaled. Cannabis vaping may be a safer alternative than cannabis smoking, but its long-term health effect of use is still unclear. With the increasing popularity of cannabis vaping among adolescents and young adults, it is crucial to investigate the sociodemographic correlates and risk factors to consuming cannabis through vaporisers and e-cigarettes. | null |
CRD42020153595 | Is social media use related to level of social anxiety? | Social anxiety is a kind of mental health disorder, suffering from which individuals have a strong desire to make a positive impression on others, however, they doubt their ability to perform well in social situations (Clark & Wells, 1995; Rapee & Heimberg, 1997). | null |
CRD42021293383 | The objective of this systematic review and meta-analysis is to provide a comprehensive review of the association between pre-existing depression and susceptibility to Long COVID-19 (i.e., post-COVID-19 syndrome). | Long COVID-19 and pre-existing depression. | null |
CRD42020196805 | This systematic review seeks to synthesise methodological information across studies that use self-report ecological momentary assessment (EMA;or experience sampling methods, ESM;or daily diaries) to measure the outcome self-compassion. We are also interested in conducting a meta-analysis should enough studies involving ecological momentary interventions (EMI) exist.
Rationale
This project examines the use of ESM in investigating the construct self-compassion. This project also seeks to review the effectiveness of EMI for self-compassion and its effects on related psychological mental health constructs. Increasingly, such methods of collecting data are being applied in clinical psychology to understand mental health. To our best knowledge, the literature lacks a comprehensive synthesis of this methodology in self-compassion research. This review seeks to synthesize methodological information across studies that use self-report EMA with self-compassion. We seek to identify common design considerations, implementation approaches, challenges encountered, and provide recommendations for future research using EMA within the self-compassion literature.
Objectives
Our review focuses on four methodological topics:(1)sample and publication characteristics, including age and other demographic characteristics;(2)EMA data collection methods, including procedures related to sampling duration and frequency and types of mobile devices used;(3)study implementation issues, including technical and logistical challenges, training of participants in EMA methods, and participant compliance;(4)a meta-analysis of the outcome data reported in the included papers which feature an EMI. This review seeks to summarize the existing literature in this area, highlight similarities and differences in findings between ESM studies and cross-sectional and lab-based studies, and develop recommendations regarding best practices when designing, implementing, and reporting EMA studies within self-compassion literature. | Self-compassion | null |
CRD42018089556 | Does the topical use of fibroblast growth factors improve wound healing of skin burns compared to others treatments or placebo? | Skin plays a crucial role in the sustenance of life through the regulation of water-electrolyte balance, body temperature, and by acting as a barrier to external noxious agents including microorganisms. Burn is a devastating trauma that breaks this protective skin barrier. More than six million people experience burns worldwide, accounting for an estimated 265,000 deaths annually. Non-fatal burns are also a leading cause of morbidity and constitute a major public health problem. Survivors face additional clinical, psychological and social challenges, and therefore, further specialised treatments are needed to achieve rehabilitation and social reintegration. Delayed wound healing often leads to severe skin scarring that evolves over years after injury. | null |
CRD42025637858 | What are the challenges faced by nurses managing COVID-19 patients in critical care settings, and what evidence-based strategies have been implemented to address these challenges effectively? | The systematic review focuses on the role of nurses in managing COVID-19 in critical care settings. This includes examining the challenges faced by nurses while caring for critically ill patients during the COVID-19 pandemic, such as increased workload, mental health strain, infection prevention measures, and patient management complexities.
The review also explores evidence-based strategies implemented to address these challenges, aiming to improve nurse well-being, enhance patient outcomes, and optimize nursing care delivery in critical care environments. This domain is highly relevant to understanding the healthcare system's response to public health emergencies and the pivotal role of frontline nursing professionals. | null |
CRD42021275837 | 1. How is discharge and transition to other services experienced by people leaving adult community mental health services?2. What experiences do staff have when supporting people during discharge and transition from adult community mental health services?3. What can lead to positive or negative experiences of discharge and transition to other services? | Discharge and transition from adult community mental health services. People using mental health services are discharged at the point that their use of the service comes to an end. The support a person receives may then be transferred to another mental health or physical health support service or to their general practitioner (GP), so the person will experience a service transition.Community mental health service: a service offering support for people experiencing mental health conditions, provided in a community or outpatient setting.Services that meet the following criteria will be included in the review: 1. Support is provided in a community or outpatient setting. 2. Secondary care services 3. Multi-disciplinary teams 4. Offer long-term support, defined as: not having a maximum length of stay of two months or less, or a maximum number of sessions or contacts. Therefore, services providing rehabilitative support would be included, but acute services providing crisis support to people in the community as an alternative to hospitalisation, such as crisis houses, would be excluded. Exclusion criteria: 1. Voluntary sector or primary care mental health services, such as IAPT. 2. Support from a single therapist 3. Residential settings, including e.g. residential eating disorder services provided in the community. People aged fourteen and over who have used and experienced, or will experience, discharge from a community mental health service.Staff who work in community mental health services or services that support people who have been discharged from community mental health services. This review will include studies that focus on discharge and transition from an adult community mental health service. | We will exclude studies of the experiences of people using or working within services that solely offer support for dementia or other organic, neurological conditions, or to people who experience substance misuse where there is not a requirement that they also experience mental health conditions to access the service. For example, dual diagnosis services that support people who experience both substance misuse issues and mental health conditions would be included but a service solely providing support to people with opioid dependency, with no other inclusion criteria related to mental health would be excluded. 1. Transitions form forensic services. 2. Transition from acute psychiatric inpatient settings. However, transitions from hospital-based day programs will be included (if support is offered for more than 2 months, and does not have a maximum number of contacts) 3. Transitions from child and adolescent mental health services (CAMHS) to adult services will also be excluded, since this process has a broad, independent literature, which has recently been reviewed. 4. Individual, one-to-one or group therapy interventions that are provided independently of a mental health service. For example, studies focusing on ending individual or group psychotherapy interventions will be excluded, unless this is discussed in the broader context of leaving a community mental health service. |
CRD420250645328 | Which verbal and non-verbal communication behaviours displayed by therapists are associated with constructs of the therapeutic alliance in therapeutic interactions involving mental health practitioners and their patients? | The therapeutic alliance is broadly defined as the collaborative relationship between a therapist and their client. It is described as having three main components, the therapist-client bond, agreement over the goals of therapy and agreement of the tasks of therapy. Any mental health practitioners (psychiatrists, psychologists, nurses, therapists, etc) and real patients experiencing mental health difficulties. Interactions that involve professional or patients outside of a mental health setting will be excluded, as well as studies using students as practitioners or role play/simulated interactions. Therapeutic interactions taking place between mental health professionals and patients experiencing mental health difficulties, within a mental health setting. Not applicable | null |
CRD42020215617 | To compare the therapeutic efficacy of mindfulness therapy with conventional therapy on college students with depression disorder. | Depressive Disorder is a common mental disorder, which characterized by depressive mood (e.g., sad, irritable, empty) or loss of pleasure accompanied by other cognitive, behavioural, or neurovegetative symptoms that significantly affect the individual’s ability to function. At a global level, over 300 million people are estimated to suffer from depression, and the number is still going up. The incidence of depression among college students increases year by year, depression has become the main factor affecting the mental health of college students. | null |
CRD42021241623 | The present review is examining the quality and results of treatment research involving individuals with co-morbid mental health and common physical health conditions in which treatment outcomes included suicidal thoughts and behaviors. It is the first systematic review of the extant literature on treatments for comorbid mental health conditions and suicide risk. We are evaluating the state of the research concerning treatments for comorbid conditions and the available evidence regarding whether these treatments affect the outcomes of suicidal thoughts and behaviors along with the quality of these studies and the suicide measures used therein. | Mental health multimorbidity and suicide | null |
CRD420251019754 | To elucidate the therapeutic efficacy of relaxation therapy in chronic pain patients through a meta-analysis, thereby establishing evidence-based guidelines to optimize clinical pain management strategies. | (1)The research subjects were those with age ≥18 years old, with clear consciousness, normal thinking, and meeting the chronic pain diagnosis criteria of IASP [1], and no other severe organic diseases, severe mental disorders or consciousness disorders. (2) The study type was a randomized controlled trial of the intervention effect of relaxation therapy on patients with chronic pain. (3) The outcome indicators were pain intensity, anxiety, depression, sleep quality and quality of life. Relaxation Therapy Session PICO tags selected: Usual support | Literature exclusion criteria: literature with incomplete outcome indicators; repeated published literature; literature with incomplete relevant data |
CRD42023425768 | 1. What are the duration and components of health promotion interventions designed to improve health outcomes in people living with Multiple Long-Term Conditions? | Infectious Diseases; Chronic Kidney Disease; Chronic Obstructive Pulmonary Disease; Depression; Anxiety; Multiple chronic conditions; Diabetes Mellitus Due to increased life expectancy, urbanization, and improved care for infectious diseases, chronic non-communicable diseases are becoming more common globally. Key conditions include respiratory diseases such as COPD, cardiovascular disease, hypertension, diabetes, kidney disease, and mental health conditions like depression and anxiety. The coexistence of two or more chronic conditions, termed multiple long-term conditions (or multimorbidity), is also growing in prevalence and has a significant impact on health and patient-reported outcomes, and their quality of life due to the significant disease and treatment burden. All studies that include patients having co-morbidities will be included (specific conditions listed in the paper cited below will be investigated). Azcoaga-Lorenzo, A., Akbari, A., Davies, J., Khunti, K., Kadam, U.T., Lyons, R., McCowan, C., Mercer, S.W., Nirantharakumar, K., Staniszewsk, S. and Guthrie, B., 2022. Measuring multimorbidity in research: Delphi consensus study. BMJ Medicine, 1(1), p.e000247. We will assess the impact of various interventions on the outcomes among people living with multimorbidity/MLTCs; compare the outcomes of the intervention across various studies. The outcomes among people living with multimorbidity/MLTCs who are receiving standard or routine care. | null |
CRD420251027536 | Review Objectives and Questions: | Population: Adults (aged 18–65 years) diagnosed with substance use disorders (SUDs) (e.g., alcohol, opioids, stimulants) as defined by DSM-5 or ICD-11 criteria. Individuals with co-occurring mental health conditions (e.g., depression, anxiety, PTSD) if SUD is the primary focus of VR intervention. Participants in any treatment setting (e.g., outpatient clinics, residential rehab, community programs, correctional facilities). Intervention Context: Studies evaluating vocational rehabilitation (VR) programs, including: Supported employment (e.g., Individual Placement and Support [IPS]). Skills training (e.g., job readiness, occupational therapy). Psychosocial/workplace behavioral interventions. Policy/systemic VR approaches (e.g., employer partnerships). Outcomes: Employment-related outcomes (e.g., job acquisition, retention, wages). Recovery metrics (e.g., sobriety maintenance, quality of life). Vocational Rehabilitation; Substance Use Therapy Intervention (I): Specify the Treatment or Approach Determine the type of intervention to address SUDs. This could include: Behavioral Therapies: Cognitive Behavioral Therapy (CBT), Motivational Interviewing (MI). Vocational Rehabilitation: Skills training, supported employment programs. Medical Treatments: Medication-Assisted Treatment (MAT) such as methadone or buprenorphine. Holistic Approaches: Mindfulness-based therapies, physical activity programs. Example: Implementing Individual Placement and Support (IPS) for vocational rehabilitation alongside MAT. Systematic Reviews and Meta-Analyses: Reviews synthesizing evidence on interventions, outcomes, or prevalence rates in substance use disorders. Scoping Reviews: Reviews mapping the extent and nature of research on integrated care or other frameworks addressing substance use disorders. | Population: Studies focusing solely on non-SUD populations (e.g., VR for physical disabilities or severe mental illness without SUD comorbidity). Adolescents (<18 years) or older adults (>65 years) unless data are stratified for separate analysis. Intervention/Context: VR programs not explicitly tailored for SUDs (e.g., generic workforce training). Studies without measurable employment/recovery outcomes. Study Design: Non-systematic reviews, opinion pieces, or gray literature. Studies published before 2014 (to prioritize recent evidence). Type of Studies: Exclude studies that do not use appropriate study designs (e.g., case reports, opinion pieces). Exclude studies with durations that are too short to demonstrate meaningful outcomes (e.g., interventions lasting less than three months). Population: Exclude studies focusing on populations outside the target age range (e.g., children or older adults if the focus is on young adults). Exclude studies that do not specifically address SUDs or include populations with co-occurring conditions not relevant to the review. Interventions: Exclude interventions that are not vocational rehabilitation-focused (e.g., purely medical treatments without vocational components). Exclude interventions that are not evidence-based or lack a clear theoretical framework. Outcome Measures: Exclude studies that do not report relevant employment-related outcomes (e.g., job placement rates, sustained employment). Exclude studies with incomplete or ambiguous outcome data. Randomized Controlled Trials (RCTs): Studies that use random allocation to intervention and control groups to evaluate the effectiveness of interventions for substance use disorders. Quasi-Randomized Controlled Trials (QRCTs): Trials with allocation methods that are not strictly random but still aim to compare intervention effects. Controlled Quasi-Experimental Designs (QEDs): Studies that involve a control group but lack randomization, focusing on interventions for substance use disorders in specific populations. Observational Studies: Cross-sectional, cohort, or case-control studies that provide prevalence, incidence, or associations related to substance use disorders. Qualitative Research: Studies exploring experiences, beliefs, and practices related to substance use disorders among specific groups (e.g., refugees or students). |
CRD42022293569 | What is the nature of #fitspiration on social media, and what is the impact of viewing this content? | The nature of #fitspiration content posted on social media. Impact of viewing #fitspiration content on self-image, mood, eating and exercise behaviour (body satisfaction, mood, self-esteem, self-objectification, exercise behaviour and eating attitudes/behaviour). | null |
CRD420250634441 | What is the effects of mindfullness-based cognitive therapy on quality of life and mental health among women with cancer? | Mindfulness-based Cognitive Therapy; Quality of Life; Mental Health Assessment Status; Cancer We will identify the effect of mindfulness-based cognitive therapy on quality of life and mental health of women with cancer Adult women (18+) with any type and stage of cancer regardless of current treatment status (undergoing or completed adjuvant treatment) Mindfulness-based Cognitive Therapy Mindfulness-Based Cognitive Therapy PICO tags selected: Usual Care; Waiting list control; Education | Mindfulness-Based Stress Reduction (MBSR), mindfulness-based cancer recovery (MBCR), Mindfulness-based art therapy (MBAT) |
CRD420250654921 | What is the impact of waiting times on patient health outcomes in total joint replacement for osteoarthritis? | Osteoarthritis; Total knee arthroplasty; Arthroplasty; Hip replacement ; Waiting time; Waiting list control For patients with severe osteoarthritis (OA), total joint replacement (TJR) is a cost-effective and clinically effective treatment which improves function and quality of life (QOL).The number of TJR procedures for OA in several countries has increased steadily over the past two decades and is projected to continue.The increasing burden of OA combined with demand for TJR surgeries has contributed to a simultaneous increase in waiting times for these interventions. Furthermore, waiting times have been exacerbated by the reduction in the number of elective joint replacement procedures which occurred during the COVID-19 pandemic. It is necessary to understand the impact of waiting times on clinical and patient-reported outcomes from TJR. Inclusion: Adults (aged 18 years or older) with osteoarthritis on hospital waiting lists for total knee or hip replacement. Waiting time; Waiting list control; Delayed treatment; Delayed surgery Waiting times from referral for hip or knee replacement to date of surgery (i.e. time on waitlist and waiting longer than recommended) PICO tags selected: Usual Care Unexposed controls (i.e. undergoing surgery within recommended time frames) | Exclusion: Adolescents and children (under 18 years of age). Non-elective procedures (i.e. trauma/emergency). |
CRD420251031478 | 1. To identify and synthesize key contributing factors to academic stress across non-Western settings in existing literature | High school students experiencing academic stress (including test/exam anxiety) in non-Western schooling settings Social Support; Parental Support; Social Norms Studies that explore factors contributing to academic stress (e.g., academic pressure, parental expectations, cultural norms, workload). | University students Postgraduate students Elementary students High school students in Western school settings Ethnic-minority students experiencing academic stress in Western countries Studies focusing on general stress and/or mental health issues unrelated to academic stress |
CRD420251039608 | To analyze the manifestations of baby blues in the postpartum period, with an emphasis on the emotional and psychosocial impacts experienced by postpartum women, as well as the possible consequences for maternal health and the development of support and intervention strategies | postpartum women with baby blues Postpartum Care | Postpartum women with no baby blues . |
CRD420251014754 | Primary Research Question: | Study Population: Physicians and surgeons, irrespective of specialty. Study Designs: Cross-sectional and cohort studies. Timeframe: Studies published after 2020 to focus on post-COVID effects. Settings: All healthcare settings, including hospitals, clinics, and academic institutions. Outcomes of Interest: Burnout, depression, and suicide risk among physicians and surgeons. Suicide Prevention; Depression Management Program Burnout, Depression, and Suicide as Primary Exposures: Studies must assess burnout, depression, or suicide risk using validated tools (e.g., Maslach Burnout Inventory (MBI), PHQ-9, GAD-7, standardized suicide risk assessments). Workplace and Systemic Factors as Exposures: Studies examining long working hours, emotional exhaustion, administrative burden, specialty-related stress, physician autonomy, and institutional support will be included. Post-pandemic changes, such as workforce shortages, telemedicine adoption, and altered physician-patient dynamics, will also be considered. Interventions for Burnout and Suicide Prevention (if assessed in studies): Studies evaluating organizational policies, mental health programs, resilience training, wellness initiatives, or physician support systems will be included if they analyze their effectiveness in reducing burnout, depression, or suicide rates. Types of Studies to Be Included: Observational Studies: Cross-sectional studies examining the prevalence of burnout, depression, or suicide risk in physicians and surgeons. Cohort studies assessing associations between work-related stressors and mental health outcomes over time. Quantitative Studies Using Validated Measures: Studies utilizing standardized tools such as Maslach Burnout Inventory (MBI), PHQ-9, GAD-7, or suicide risk assessments. Timeframe: Studies published after 2020 to capture post-COVID-19 effects on physician mental health. Settings: Studies conducted in hospitals, clinics, academic medical centers, and other healthcare institutions worldwide. | Exclusion Criteria: Narrative reviews, case reports, editorials, and qualitative studies without primary data. Studies focusing only on nurses, medical students, or non-physician healthcare workers without physician-specific da |
CRD420250613439 | We aim to conduct a systematic review of studies examining spiritual practices, beliefs, and orientations that influence resilience and mental health disorders (cognitive impairment, depression, anxiety, suicide) in older adults residing in low- and middle-income countries (LMICs). The primary questions guiding this review are: | Examining how spirituality may influence or enhance resilience and mental Health Disorders (cognitive impairment, depression, anxiety, suicide) among older adults in low- and middle-income countries (LMICs) Inclusion criteria:1. Older adults, defined by WHO as individuals aged 60 years and above.2. Participants from countries classified by the World Bank as low- and middle-income countries (LMICs).3. Research articles published in English.4. Studies focused on human subjects.5. Studies published between 2000 to 2024Exclusion criteria:1. Participants younger than 60 years.2. Studies not available in English. the intervention will include (i) Spirituality alone, encompassing spiritual beliefs, practices or orientations or (ii) Spirituality together with psychosocial interventions in order to enhance resilience in the older population. Spirituality will include a range of spiritual practices and expressions, such as prayer, meditation, participation in religious services, community engagement in faith-based settings, and personal spiritual beliefs that foster meaning, connection, and purpose. The intervention may occur independently or alongside supportive psychosocial interventions such as counselling, group therapy, or community support. The spirituality intervention can vary in type, duration, and intensity but must include structured or habitual engagement in practices or beliefs related to spiritual life to differentiate it from other non-spiritual activities or general coping mechanisms.Exclusions:We will exclude general wellness or self-help activities that lack a structured spiritual component, as well as interventions involving secular mindfulness-based practices that do not explicitly integrate a spiritual or faith-based approach. This will include groups with different levels or types of spirituality. | null |
CRD42025639771 | RQ1 - Is there a relationship between cancer survivors' mental health and caregivers' mental health?
RQ2 - Is there a relationship between cancer survivors' fear of cancer recurrence/fear of cancer progression and caregivers' fear of cancer recurrence/fear of cancer progression?
RQ3 - Is there a relationship between cancer survivors' mental health and caregivers' fear of cancer recurrence/fear of cancer progression?
RQ4 - Is there a relationship between caregivers' mental health and cancer survivors' fear of cancer recurrence/fear of cancer progression?
RQ5 - Are there any significant moderator variables that account for the relationship between mental health and fear of cancer recurrence/fear of cancer progression in cancer survivor-cancer caregiver dyads? | This review addresses Fear of Cancer Recurrence/Fear of Cancer Progression. Fear of cancer recurrence is defined as the general tendency to fear or worry that cancer might return, when remitted, while fear of cancer progression is defined as the general tendency to worry that cancer might progress or metastasize, in the case of an acute diagnosis. Certain authors consider that the two concepts are overlapping and take both terms into consideration. Our review will allign with the perspective that fear of cancer recurrence and fear of cancer progression are frequently overlapping phenomena, thus the two terms will be used interchangeably.
Generally, elevated levels of fear of cancer recurrence (i.e., accompanied by high and persistent levels of worry and hypervigilance to bodily symptoms) can become clinically relevant, potentially limiting daily functioning and quality of life and bringing about significant healthcare costs. | null |
CRD42024505534 | Questions
1) What is the prevalence of hysterectomy in India, and what are the key demographic determinants, including regional variations?
2) How do the morbidity and surgical outcomes of different hysterectomy techniques (vaginal, abdominal, laparoscopic, and robotic-assisted) compare in tertiary care centers across India?
3) What is the association between hysterectomy and subsequent health conditions such as hypertension and endocrine disorders, considering the role of preoperative factors? | The focus of this systematic review and meta-analysis is on hysterectomy procedures in India. Hysterectomy, the surgical removal of the uterus, is a common gynecological procedure often performed for various medical reasons, including uterine fibroids, endometriosis, gynecologic cancer, and abnormal bleeding. This study aims to explore the prevalence, determinants, and outcomes of this procedure, with an emphasis on the various surgical techniques (vaginal, abdominal, laparoscopic, robotic-assisted) and their impact on women's health and wellbeing. The review will also consider the association between hysterectomy and subsequent health conditions such as hypertension and endocrine disorders, assessing the influence of demographic and preoperative factors. | null |
CRD420251033764 | The objective of this systematic review is to investigate the effect of upper extremity rehabilitation on fatigue in individuals with multiple sclerosis. | Adult individuals ( above 18 years) diagnosed with MS. Randomized controlled trials, pilot RCTs, and crossover studies. Articles published in English. Articles reporting fatigue outcomes assessed by subjective or objective measurement tools. Interventions involving upper extremity rehabilitation (e.g., physical therapy, exercise programs, or rehabilitation strategies targeting the upper extremity). Upper Limb Training Upper limb rehabilitation refers to a structured program of therapeutic interventions aimed at improving the function, strength, coordination, and mobility of the shoulder, arm, elbow, wrist, and hand. In individuals with multiple sclerosis (MS), upper limb rehabilitation targets impairments such as muscle weakness, spasticity, reduced dexterity, sensory deficits, that can limit daily activities and quality of life. Rehabilitation programs may include: Task-oriented training: Practicing real-life activities such as reaching, grasping, and manipulating objects. Strengthening exercises: Targeting specific muscle groups to enhance upper limb power and endurance. Range of motion exercises: To maintain or improve joint flexibility and prevent contractures. Fine motor skill training: Focusing on hand and finger movements for improved dexterity. Sensory re-education: Techniques to improve sensory function and proprioception. Constraint-induced movement therapy (CIMT): Encouraging the use of the affected limb by restraining the unaffected side. Robot-assisted therapy: Using robotic devices to assist or resist movements in a controlled way. Neuromuscular electrical stimulation (NMES): Applying electrical currents to stimulate muscles and improve motor control. PICO tags selected: Placebo; Usual Care • Adult individuals ( above 18 years) diagnosed with MS. • Randomized controlled trials, pilot RCTs, and crossover studies. • Articles published in English. • Articles reporting fatigue outcomes assessed by subjective or objective measurement tools. • Interventions involving upper extremity rehabilitation (e.g., physical therapy, exercise programs, or rehabilitation strategies targeting the upper extremity). Randomized controlled trials (RCTs), pilot randomized controlled trials, crossover trials. | Articles including individuals with other neurological or systemic conditions in addition to MS. Interventions not focused on the upper extremity (e.g., lower limb or balance training). Articles focusing only on pharmacological treatments. Articles do not report fatigue measurements or outcomes. Exclusion interventions: Studies will be excluded if the intervention involves: Non-specific interventions that do not focus on upper limb rehabilitation (e.g., general physiotherapy or non-targeted exercise programs). Pharmacological treatments or drug therapies aimed at fatigue or other symptoms of multiple sclerosis, rather than physical rehabilitation. Psychological or behavioral interventions that do not directly address upper extremity function, such as cognitive behavioral therapy or interventions for mental health without a focus on motor skills. Surgical interventions (e.g., upper limb surgery or any invasive procedure) or medical treatments that do not include rehabilitation components. Interventions solely focused on lower limb rehabilitation or other body regions, without addressing upper extremity function. Passive interventions that do not actively engage the patient (e.g., bed rest, passive range of motion exercises without active involvement). • Articles including individuals with other neurological or systemic conditions in addition to MS. • Interventions not focused on the upper extremity (e.g., lower limb or balance training). • Articles focusing only on pharmacological treatments. • Articles do not report fatigue measurements or outcomes. |
CRD42022319424 | What are adolescents’ perspectives on and experiences with post primary school-based suicide prevention (PSSP) interventions, as participants/end-users, intervention advisors, facilitators, and co-designers and co-researchers? | Adolescents’ perspectives on and experiences with PSSP, as participants/end-users, intervention advisors, facilitators, and co-designers and co-researchers. | null |
CRD420251004580 | The primary objective of this review is to investigate the association between psychological, social, and biological factors and negative body image among Black young adults. | Inclusion: Young adults (defined as individuals aged 18-25 years) who identify as Black (referring to individuals from the African diaspora or with African heritage) Individuals with comorbid conditions such as Body Dysmorphic Disorder (BDD) or eating disorders, due to the link between negative body image and mental health conditions. Studies that assess negative body image including body dissatisfaction, body image disturbance, or body image concerns as an outcome. Studies exploring psychological factors (e.g., self-esteem, mental health conditions), social factors (e.g., media influence, social support, discrimination, internalised racism, acculturation, sociocultural norms, beauty standards), and biological factors (e.g., physical appearance characteristics, weight-related factors, genetic predispositions if directly explored in relation to body image dissatisfaction) Observational studies (e.g., cross-sectional, cohort, case-control) using quantitative, qualitative, or mixed-methods approaches that explore associations or relationships. | Exclusion Studies focusing on children or older adults (outside the 18-29 age range), studies that do not specify the race/ethnicity of participants or include mixed populations without separate data for Black young adults Studies that primarily focus on positive body image without assessing negative aspects, studies focused solely on eating disorders without a specific measure of body image dissatisfaction, and studies that do not explicitly address body image. Intervention studies (e.g., randomized controlled trials), systematic reviews, meta-analyses, theoretical articles, and case studies. |
CRD42022310113 | What methods of measuring eco-anxiety are available and what is their quality? | With the public concern about the effects of human impact on environment rising, so does the distress one may feel as a result. An umbrella term 'eco-anxiety' has been introduced in the recent years to describe a range of negative mental states surrounding concern, guilt, feelings of loss, fear, anger and indeed anxiety; all related to climate change and negative human-driven changes to the environment. Recent years saw a number of psychometric scales that aim to determine the extent of those symptoms. | null |
CRD42023391724 | How effective are peer support, behavioral interventions, and other nonpharmacological interventions in reducing chronic pain among individuals with SCI? | Adults with a traumatic spinal cord injury who experience chronic pain | null |
CRD42024509206 | 1. What is the overall strength and direction of the relationship between distress tolerance and depression among children and adolescents across relevant studies?
2. Are there any moderating variables or factors that influence the relationship between distress tolerance
and depression among children and adolescents? | Depression is a prevalent and intricate mental health challenge confronting children and adolescents, garnering increasing attention from both researchers and practitioners. The onset of depression in early life presents a significant quandary, affecting not only the individuals experiencing it but also posing challenges for parents and educational institutions. Adolescents reporting elevated depressive symptoms have shown a prevalent point prevalence of around 34%, with a discernible upward trajectory. Given the profound impact of depressive symptoms on the well-being and developmental trajectories of young individuals, a comprehensive exploration of contributing factors and underlying mechanisms becomes imperative.
This meta-analysis is specifically oriented toward a thorough examination of the nuanced relationship between distress tolerance and depression in children and adolescents. The definition of distress tolerance, denoted as DT, aligns with established frameworks and insights derived from previous scholarly investigations. | null |
CRD42021265812 | Can using Written Emotional Disclosures Intervention benefit health care workers psychological well-being? | This narrative literature review will focus on the improvement of psychological well-being of all health care workers using Written Emotional Disclosures interventions. | null |
CRD42022326393 | The purpose of this systematic review is to present a conceptual framework of the effectiveness of breast cancer-related psychosocial interventions across the trajectory. | Among women, breast cancer is the most common type of cancer diagnosed, with 2, 088, 849 cases in 2018 (most recent data) across the different countries of the world (Bray et al., 2018). In recent years, remission rates have increased up to 96% among women in North America. Although cancer incidence rate appears to be declining over years, the number of diagnoses is still alarming (Canadian Cancer Society, 2019, Bray et al., 2018, Jemal et al., 2011). On the positive side, high remission rates and lower incidence rates are reducing the number of deaths in women with breast cancer. However, this increase in survival also means that there are more cancer survivors who continue to live with significant symptoms of cancer-related psychological distress (Bower, 2008). Psychological symptoms can emerge or increase at different moments during the breast cancer trajectory: 1) screening phase 2) diagnosis phase 3) post-diagnosis/pre-treatment phase 4) treatment phase 5) post-treatment phase and 6) survivorship (Smit et al., 2019). | null |
CRD420250619102 | What are the barriers and facilitators influencing help-seeking behaviours in those experiencing symptoms related to perimenopause and menopause? | Perimenopause, menopause, help-seeking Adults who identify as being within the perimenopausal period or menopausal. No exclusion criteria based on participant characteristics e.g., age, medically induced menopause. Mental health services utilization; Menopause Education | null |
CRD42021265057 | How are firesetting behaviours operationalised, measured and conceptualised in the existing research?
What is the prevalence of firesetting behaviours in community and apprehended populations?
Are there differences in prevalence across ages, genders, and settings? | Firesetting behaviours and/or arson | null |
CRD420251007770 | What is the prevalence of Medical Student Syndrome (MSS) among medical students? | Medical students (undergraduate, graduate, or post-graduate) enrolled in medical schools in South Asia (e.g., India, Pakistan, Bangladesh, Sri Lanka, Nepal, Bhutan, Maldives, and Afghanistan). Students aged 18 years and older. Cognitive Behavioral Therapy; Stress Management; Resiliency Promotion; Mental Health Care Education; Mental health services utilization Non-randomized studies Observational studies Qualitative studies Prevalence studies Intervention studies | Non-medical students or students from non-medical disciplines. |
CRD42024572480 | - What is the dropout rate in psychotherapy for Body Dysmorphic Disorder (BDD)?
- What factors contribute to dropout rates in psychotherapy for BDD? | Psychotherapy for BDD | null |
CRD42024567304 | What is the signature in brain oscillations in adult patients with highly disabling neurological disorders when comparing placebo versus active interventions? | highly disabling neurological disorders such as chronic pain, stroke, traumatic brain injury, and cognition disorders. | null |
CRD42020160063 | Chronic diseases are the leading global causes of illness, disability and death, despite the advances in their diagnosis, treatment and prevention. They are associated with high disease burden and significant mental health co-morbidities and require integrated, multidisciplinary treatment. Photobiomodulation is a novel, non-invasive, light-based therapy, with increasing research evidence regarding its efficacy in treating depression, inflammation and fatigue and improving quality of life in individuals with chronic disease.
There have been no systematic reviews of photobiomodulation in chronic disease to date and this review will aim to assess the effect of photobiomodulation on depression, fatigue, inflammation and quality of life in individuals suffering from chronic disease.
Can photobiomodulation improve depression and fatigue in chronic disease?
Is photobiomodulation effective in improving inflammation associated with chronic disease?
Can photobiomodulation improve quality of life in individuals with chronic disease? | Chronic diseases are the main cause of morbidity and mortality worldwide and their incidence and prevalence are increasing despite the advances in their diagnosis, prevention and treatment.
Individuals suffering from chronic illnesses are significantly more likely to experience depression, fatigue and impaired quality of life, however, evidence for effective interventions has been mixed, with antidepressant medications, cognitive-behavioural therapy, exercise and mindfulness-based interventions having the strongest evidence base. Photobiomodulation has recently emerged as an intervention of interest due to accumulating research evidence regarding its effectiveness in improving depression, fatigue and quality of life as well as inflammation associated with chronic disease. | null |
CRD420250648113 | Population: Nurses.Intervention: Aspects of the work environment (working hours, resources, organizational culture).Comparison: Nurses in different work environments (e.g., well - resourced vs. poorly resourced).Outcome: Burnout levels.Study design:cross - sectional studies.Question: Among nurses (P), does a lack of resources in the workplace (I) compared to well - resourced workplaces (C) result in higher levels of burnout (O) in various study designs (S)? | Occupational mental health of nurses Registered nurses in tertiary hospitals, secondary hospitals, and primary hospitals Discharge By Continence Nurse; Mental Health Screening Not Applicable | Absent nurses on personal leave, sick leave, maternity leave and rehired and advanced nurses |
CRD420250651620 | Exploring the advantages of psychological therapy compared with conventional therapy in rehabilitation care for heart failure patients. | Heart failure (HF) has become a global public health problem, posing a serious threat to human health. It is estimated that there are over 6 million patients with heart failure in the United States alone. [1] Although the survival rate after diagnosis of heart failure has improved, it is reported that patients with heart failure are hospitalized on average once a year after their initial diagnosis. In addition, the 1-year mortality rate after diagnosis reached 20%. Countries with an aging population are facing a more serious situation, which means a higher incidence rate and a worse prognosis.Heart failure, a complex and progressive disease, poses a huge burden on patients, families, and the entire healthcare system.
It is related to adverse consequences such as increased mortality rate, frequent hospitalization, and decreased exercise ability. In addition to physical problems, this disease is also related to psychological disorders including depression and anxiety. Some reports indicate that the main risk factor for disability and death caused by heart failure is depression, with 9% to 60% of heart failure patients suffering from depression. | null |
CRD42023466214 | What are the experiences of ethnic minority adolescents and their caregivers accessing and using CAMHS in the UK? | Experiences of CAMHS in the UK. | null |
CRD42023385503 | 1. What is the level of mental health literacy of tertiary educators according to the following parameters: (a) mental health knowledge; (b) attitude, beliefs, and stigma on mental health; and (c) help-seeking behaviour?
2. What are the existing interventions for improving tertiary educators’ mental health literacy (MHL) and is there any evidence of effectiveness? | Mental health literacy involves the ability to recognise specific mental health difficulties, knowing how to seek information, knowledge of risk factors/causes, treatments, professional support, and attitudes that promote recognition and help-seeking (Jorm et al., 1997)
Jorm, A. F., Korten, A. E., Jacomb, P. A., Christensen, H., Rodgers, B., & Pollitt, P. (1997). “Mental health literacy”: a survey of the public's ability to recognise mental disorders and their beliefs about the effectiveness of treatment. Medical journal of Australia, 166(4), 182-186. | null |
CRD42024611381 | How Intersectional are mental health interventions for marginalized adolescents? To what extent are intersectionality applied to adolescent mental health interventions? We aim to investigate the extend to which existing mental health interventions for vulnerable and marginalized adolescents are informed by intersectionality, and to conduct an intersectionality-based analysis utilizing a structured checklist. | More than 50% of mental health disorders first appear in adolescence and carry a long-term burden in adult life. Despite widespread recognition of the importance of promoting adolescent mental health, there remains a significant gap between the demand for services and the availability of resources. In addition, intersectionality has been largely ignored in adolescent mental health interventions. A dearth of studies on intersectionality and mental health service research urges researchers to apply the principles of intersectionality to mental health intervention. To our knowledge, only few review studies have examined whether an intervention
was guided by intersectionality. This review aims to assess how mental health interventions for adolescents are informed by the intersectionality framework and identify the intervention characteristics that are instrumental in incorporating intersectionality theory. | null |
CRD42024501872 | 20 years of SAGE: What affects mental health in low- and middle- income countries? | Mental health, Suicide, Depression, Mild cognitive impairment (MCI), Subjective cognitive complaint, Anxiety, Stress, Happiness, Public Health. | null |
CRD420251029236 | We aim systematically review the literature for studies investigating psychotherapy for adolescent inpatients with eating disorders. The main objective is to investigate reduction in eating disorder psychopathology following psychotherapeutic treatment in hospitalized adolescents with eating disorders | - The following eating disorder diagnoses: anorexia nervosa, bulimia nervosa, atypical anorexia nervosa, and atypical bulimia nervosa, unspecified eating disorder - Diagnoses according to DSM-IV, DSM-5, ICD-10, or ICD-11 - Hospitalized patients (including day hospital) - Patients aged 10 to 19 years (WHO definition adolescence) Psychotherapy We will include studies using any type of psychotherapeutic intervention, including group therapy, individual therapy, and family based therapy. Longitudinal clinical studies (cohort studies, case-control studies, and randomized controlled trials) investigating psychotherapy in hospitalized adolescents with eating disorders. English language studies published in international peer-reviewed journals will be included. | - Patients with obesity - Patients with Binge Eating Disorder (BED) - Outpatients (if no separate analyses are conducted on inpatients) Studies only investigating e.g., physiotherapy, pharmacological therapy, or nutritional therapy, without investigating psychotherapy Case reports |
CRD420250620869 | What is the current evidence on the effects of nutritional interventions in adult intensive care unit (ICU) patients and outcomes of post-intensive care syndrome (cognitive, physical, mental health, sleep outcomes)? | Critical Illness; Nutrition Therapy; Enteral nutrition; Nutritional Supplementation; Nutritional Support; Intensive care unit acquired weakness; Delirium; Cognitive impairment; Sleep disturbances; Quality of Life; Health-Related Quality of Life; Assessment Of Quality Of Life; Functionally Independent; Social functioning; Functional ability Patients who experience critical illness are at risk of long-term physical, cognitive, and mental health challenges, collectively known as Post-Intensive Care Syndrome (PICS). These challenges include ICU-acquired weakness, delirium, cognitive impairments such as dementia, sleep disturbances, and mood disorders, all of which can severely impact recovery and quality of life. Inclusion: Adults (older than 18 years) admitted to ICU or post-ICU survivors Intensive Care Unit (ICU) nutritional interventions are defined as those applied to patients and survivors with the aim of affecting clinical outcomes during and after ICU stay. Examples include adjustments to enteral and parenteral nutrition, dietary supplements, timing of nutritional interventions, and specific dietary plans. PICO tags selected: Placebo; Usual Care; Standard Dose | Exclusion: Adolescents (under 18 years of age), adults with traumatic brain injury or patients in neurocritical care We will not include studies that utilized combined interventions, defined as those combining a nutritional intervention with additional elements such as physical/psychological rehabilitation or pharmacotherapy. |
CRD42024595791 | 1) Does Written Exposure Therapy (WET), compared to any control condition, result in significant changes in PTSD symptom outcomes?
2) What is the pooled dropout rate for WET? | PTSD is prevalent cross-nationally, with global prevalence rates of 3.9% and 4.6%, respectively (Koenen et al., 2017). PTSD leads to deteriorating mental health, reduced quality of life, and significant functional impairment, placing a heavy disease burden on patients. | null |
CRD420250623778 | What is the association between traumatic childhood experiences (TCEs) and sleep health based on the current evidence from systematic review and meta-analysis, and what are the potential bias among them. What are the limitations should be improved of the current published systematic review and meta-analysis. | Sleep duration, sleep quality, and sleep disorders such as apnea, sleep wake disorders, insomnia and nightmare. Adults (over 18 years) in the general population have reported TCEs. Traumatic childhood experiences (TCEs)—defined as traumatic events occurring between childhood and adolescence (ages 0-17). Including experiencing physical, emotional, or sexual abuse; witnessing violence in the home; having a family member attempt or die by suicide; and growing up in a household with substance use, mental health problems, or instability due to parental separation, divorce, or incarceration. (Centers for Disease Control and Prevention. Preventing Adverse Childhood Experiences (ACEs): Leveraging the Best Available Evidence. Atlanta, GA: National Center for Injury Prevention and Control, Centers for Disease Control and Prevention. https://www.cdc.gov/violenceprevention/pdf/preventingACES-508.pdf. Accessed October 2, 2019). Other traumatic experiences include food insecurity or not having enough food to eat, experiencing homelessness or unstable housing, experiencing discrimination, experiencing natural disasters, and experiencing medical illness. Additionally, peer, community, and collective violence. Comparable populations of adults who did not experience/report TCEs. | null |
CRD42025639827 | What are the Benefits, Challenges, and Future Recommendations of using crisis hotline among patient with mental health conditions? | mental health crisis | null |
CRD42020186572 | The objective of this review is to investigate and synthesize the body of knowledge surrounding interventions that target individuals and optimize their informal social support network, to identify gaps in such literature, and to examine the research-based evidence of the effectiveness of such interventions. The review will address the following questions:
• What empirically-supported interventions are available that may improve an individual’s social support network on dimensions of social support and/or well-being?
• How effective are such interventions?
• What is the methodological quality of such interventions?
The end goal is to examine which interventions are potentially adaptable to the rural caregiving context, as there is a specific need to enhance the informal social support systems of rural caregivers of persons with dementia; to our knowledge, no feasible informal social support interventions exist for this population. | The enhancement of informal social support networks may result in two possible types of outcome measures.
The first set of outcome measures assess the effect of the intervention on specific dimensions of social support and can include changes in support-seeking behaviours, perceived support, received support, support adequacy, social integration, and support structure.
The second outcome measures assess the intervention’s effect on dimensions of well-being and can include changes in subjective quality-of-life, feelings of burden, level of depression, negative self-appraisal, and overall mental health. Secondary outcomes may primarily include information on the barriers or facilitators involved in improving informal social support networks; in addition, differences within/between gender and relation to care recipient (in the case of other caregiving populations) may also be revealed and would prove valuable to the design of targeted interventions. | null |
CRD420251013955 | The objective of this systematic review and meta-analysis is to assess the prevalence and explore the association of suicidal behavior (including suicidal ideation, suicide attempts, and completed suicides) among patients with Chronic Kidney Disease (CKD). CKD, a condition marked by the gradual loss of kidney function, has been linked to various psychological and emotional challenges, including an increased risk of suicidal thoughts and behaviors. This review aims to synthesize the available evidence from studies that examine the prevalence of suicidal behavior among CKD patients, focusing on those at different stages of the disease, from early-stage CKD to end-stage renal disease (ESRD), including those undergoing dialysis. Additionally, the review will analyze factors that may influence the association between CKD and suicidal behavior, such as demographic characteristics, comorbidities, psychiatric conditions, and treatment modalities (e.g., hemodialysis or peritoneal dialysis). By combining data from multiple studies through meta-analysis, the review aims to provide a more accurate estimate of the prevalence of suicidal behavior in this patient population. Furthermore, the findings will highlight key risk factors that can aid in the identification of CKD patients at higher risk for suicide and improve clinical approaches to managing mental health in this vulnerable group. | Adult patients (18 years and older). Studies that assess suicidal ideation, suicidal attempts, or completed suicides in CKD patients. Patients diagnosed with Chronic Kidney Disease (CKD), regardless of stage (stage 1 to stage 5, including those on dialysis or without dialysis) if available | null |
CRD42024554547 | What literature is available on how user feedback is developed, perceived, collected or used within social care settings in the UK? | The purpose of this review is to understand from the existing literature how service user feedback is developed, perceived, collected or used in social care settings. Our definition of social care used in this study follows that as described by the Kings Fund (2024):
“Adult social care covers a wide range of activities that help people who are older or living with disability or physical or mental illness to live independently and stay well and safe. It can include ‘personal care’, such as support for washing, dressing and getting out of bed in the morning, as well as wider support to help people stay active and engaged in their communities"
However we have chosen not to include mental health services for this study. We have limited our study to This is limited to the UK. The focus of this review is on user feedback itself. Therefore, we are not including examples of individual projects which have utilised service feedback for project evaluation purposes or outcomes only (e.g. PROMs after community physiotherapy care). Individual projects may be included if they have utilised user feedback as the method for creating service or care improvement in one area (e.g. developing ways to use patient stories for improving service experience). Given the focus is on feedback, qualitative studies exploring users’ social care experiences will not be included unless this is part of feedback which the service itself has collected or utilised. | null |
CRD42024564499 | What is the evidence from published systematic reviews for the effectiveness of green care initiatives (adventure therapy, animal therapy, therapeutic farming and horticulture therapy) on mental health outcomes? | Mental health outcomes conceptualised as: mental health / wellbeing / loneliness / happiness / quality of life / cognitive decline / maladaptive behaviour / mental health diagnosis (such as depression / distress / PTSD / dementia / anxiety / suicide etc - please refer to search terms for complete list) | null |
CRD420250651065 | To systematically review and summarize the advances in the field of bipolar disorder in children and adolescents by conducting an umbrella review of the available meta-analytical evidence. | Bipolar Disorder Bipolar Disorder in children and adolescents as defined by the diagnosis of a first episode of bipolar disorder (including BD-I, BD-II, cyclothymic disorder or BD-NOS) before the age of 18 year We will include individual meta-analyses enrolling individuals with a mean age of less than 18 years and with a wide range of early-onset psychiatric and psychological disorders. Interventional meta-analysis may focus on a wide variety of outcomes. Observational meta-analysis may focus on interventions with a wide range of clinical and psychological outcomes. The control group may include healthy control subjects, subjects with risk factors for bipolar disorder among others. | We will exclude individuals with a mean age of more than 18 years and those focusing on other mental health conditions only. No limitations in this regard will be established. No limitations in this regard will be established. |
CRD42023434044 | In Children, what is the effect of Social and Cultural Influence on development of psychopathology? | General Psychopathology | null |
CRD42025512142 | How does stress perception affect emotional eating and what role do anxiety and depression play in it? | Emotional eating refers to the tendency of individuals to eat when they are unable to differentiate between hunger signals and emotional signals of discomfort, and when they are under the influence of adverse emotions, they create the illusion of hunger. Research suggests that individuals may use maladaptive eating behaviours to cope with stress to reduce these negative emotional experiences when they are experiencing stress. Emotional eating is positively associated with depression and leads to obesity in individuals. Emotional eating may also progress to various types of eating disorders, which can seriously damage an individual's physical and mental health. Currently, the mechanism by which stress perception affects emotional eating in individuals is unclear and needs to be further examined and analyzed. | null |
CRD42024606500 | This systematic review and meta-analysis aimed to (a) assess adherence to 24-hour movement guidelines in young children, preschoolers, children, adolescents and (b) explore the association of 24-hour movement behaviors (physical activity, sedentary behavior, sleep) and specific combinations of these behaviors with cardiometabolic markers in young children, preschoolers, children, and adolescents. The aim is to provide more effective and targeted interventions for health-based 24 hours to reduce the incidence of cardiometabolic risk in younger populations. | Physical activity, sedentary behavior, and sleep are three interdependent motor behaviors that together make up a 24-hour daily cycle. Studies have shown that physical activity, shorter sedentary behavior, and optimal sleep duration are independently associated with positive physical and mental health benefits for young children, children, and adolescents. However, since an increase in time for one of these behaviors will inevitably reduce the time for the other two behaviors, the researchers began to focus highly on the interdependence of 24-h motor behaviors.
According to data released by the World Health Organization in 2024, cardiovascular disease and diabetes are the leading causes of death worldwide. Metabolic syndrome is a complex of risk factors for cardiovascular disease and diabetes, caused by various cardiometabolic risk factors (abnormal blood sugar, elevated blood pressure, elevated triglyceride levels, low HDL cholesterol levels, and obesity) . Studies have shown that childhood obesity significantly increases the risk of type 2 diabetes in adult37 and cardiovascular disease and death in adult. At the same time, poor lifestyle can also lead to the occurrence of cardiometabolic risk in children and adolescents. | null |
CRD420250651294 | The aim of this meta-analysis is to evaluate the performance of wearable devices and machine learning in predicting depression, comparing feature indicators and methods in longitudinal studies. | Depression is a significant global mental health issue, yet traditional assessment methods have limitations. The integration of wearable devices with machine learning techniques has emerged as a promising approach for predicting depression. However, the effectiveness of these technologies and the optimal selection of feature indicators remain unclear.This meta-analysis aims to evaluate the performance of wearable devices and machine learning in longitudinal depression prediction. | null |
CRD42023462987 | What is the impact of cyber-bullying and online victimisation on the mental health of adolescents? | Cyber-bullying. Online Victimisation, mental health, in adolescents Participants will be adolescents aged 14 to 19 years old.For the purposes of this review an adolescent will be determined using the World Health Organisation definition whereby an adolescent is any person between the ages of 10 to 19 years.Studies which involve participants over the age of 19 and under the age of 10 will be excluded. Studies which contain participants which intersect the age range such as age 6 to 14 or 16 to 24, will be excluded unless specific data of people within the age range is reported. There are no limitations with respect to gender, ethnicity and clinical status. Exposure to cyberbullying, adolescents who have been bullied through the use of electronic communication. Exposure to online victimisation, adolescents who have experienced being singled out and treated cruelly or unjust through electronic communicationInclusionAdolescents exposed to cyber-bullying and/or online victimisationThe bullying and/or online victimisation must have been assessed prior to the participants reaching the age of 19.ExclusionPerson to person bullying and/or victimisation.Bullying and/or online victimisation which has only been assessed retrospectively in adulthood. None | null |
CRD420250649036 | What validate diagnostic algorithms exist for mental health concerns using Canadian electronic health record data? | Mental disorder Mental health concerns Inclusion: Child, adolescent and adult populations with mental health concerns. Not applicable PICO tags selected: Chart Review, Verification Of Procedures | Studies in with the primary population is older adults/geriatric and/or the diagnosis of interest is dementia. |
CRD42021236588 | Overall review question:
What are the key features, mechanisms, barriers and strengths of formal peer support in child & youth mental health services?
Sub-questions:
In what ways and in which contexts have peer support workers been involved in child and youth mental health services so far?
What are the outcomes of implementing formal peer support in child and youth mental health services?
What are the barriers and challenges of involving and pursuing formal peer support in child and youth mental health services?
What are the key features and core processes of successful formal peer support in child and youth mental health services?
What type of skills and knowledge are essential for peer support workers in child and youth mental health services? | Formal peer support in child and youth mental health services. Within this review, child and youth mental health services refers services ranging from primary care community services to specialist care mental health services and youth forensic services that support young people aged 8 to 23 with a diagnosed mental disorder (Appleton, 2000). This also includes services for parents, siblings, or carers of young people with a diagnosed mental disorder. Diagnosis of these mental disorders should be based on the fourth or fifth edition of Diagnostic Manual of Mental Disorder (DSM) or the eleventh revision of the International Classification of Diseases (ICD-11).
Formal peer support refers to those services and interventions that are delivered by a peer support worker in child and youth mental health services. A peer support worker is broadly defined as someone with lived experience of mental illness who supports others in recovery from mental illness (Repper & Carter, 2011; Collins, Firth & Shakespeare, 2016). | null |
CRD42022316931 | How do changes in depression scores differ in response to ECT treatments based on the anesthetic agent used (methohexital, propofol, ketamine, etomidate, thiopental)? | This study will examine patients with treatment-resistant depression, and how ECT treatments administered with different anesthetics will affect their depression scale scores, recovery time, seizure duration, and number of treatments required until therapeutic benefit. | null |
CRD42023475165 | In individuals with substance use disorders (SUDs), are currently available brain stimulation techniques effective in treating SUDs by decreasing substance use outcomes? | This review will investigate individuals with substance use disorders (SUDs). SUDs are a major contributor to morbidity and mortality worldwide. Although there are pharmacological, behavioral and psychosocial treatments available, they are not always effective or well-tolerated, and relapse rates continue to be as high as 60%. Neuromodulation (NM) methods, including repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS) and deep brain stimulation (DBS), may be promising brain-based approaches for the treatment of SUDs due to their ability to target addiction-associated neurocircuitry. | null |
CRD42023411995 | What are the determinants of willingness, intentions, attitudes, and behaviors related to HPV-related cancer prevention (e.g., HPV testing, cervical/anal/oropharyngeal cancer screening, HPV vaccination) among people experiencing homelessness. | HPV-related cancer prevention behaviors Types of participants include U.S. people who have ever or are currently experiencing homelessness (as defined by McKinney-Vento Homeless Assistance Act: sheltered, unsheltered, hotel/motel, doubled-up), eligible for HPV vaccination and HPV/cancer screening. The primary outcomes to be examined are prevention behaviors (primary, secondary prevention) for cancers primarily associated with HPV (i.e., cervical cancer, oropharyngeal cancer, anal cancer, penile cancer, vaginal cancer, vulvar cancer). • HPV vaccination (age 11-12 – early as 9, up to age 26 for catch-up, 27-45 with SDM) - number of doses of HPV vaccine • HPV prevention via STI prevention (e.g., condoms, partner history) • Cancer screening (HPV testing as screening, pap testing, HPV-pap co-testing, ages 21-65) | null |
CRD42024498730 | What changes do physical activity in green spaces produce in the mental health of young people? | Physical activity in nature. Mental and physical health in children and adolescents | null |
CRD420250653914 | Mitochondrial dysfunction plays a crucial role in the pathophysiology of major depressive disorder (MDD) and may lead to the release of circulating cell-free mitochondrial DNA (ccf-mtDNA). In recent years, an increasing number of studies have explored whether ccf-mtDNA could serve as a potential biomarker for MDD. However, the findings remain inconsistent. The core question of this meta-analysis is whether there are significant differences in ccf-mtDNA levels in MDD compared to healthy controls. | Major depressive disorder; Depression; Mental disorder Major depressive disorder is a mental disorder primarily diagnosed based on clinical symptom assessment, and there is an urgent need for objective biomarkers to enhance diagnostic accuracy and reliability. Inclusion: Patients diagnosed with major depressive disorder by two psychiatrists using the DSM-5 or ICD-10/11 criteria. Exclusion: The exposure factor in this study is the ccf-mtDNA levels between depressed patients and healthy controls. Inclusion: Inclusion: healthy controls or control group that does not meet the clinical diagnostic criteria for Major depressive disorder. | Exclusion: Studies that measure mitochondrial gene expression rather than ccf-mtDNA levels. Studies that the laboratory measurement methods differ between the experimental group and the control group. Exclusion: Individuals with any history of mental illness or family history. |
CRD42025645474 | This review aims to address the following primary question: How do counselling and psychotherapy clients experience the process of preference-accommodation?
The review seeks to synthesise clients’ perspectives on:
• How clients feel about being consulted about preferences in counselling and psychotherapy.
• Clients’ experiences when preferences are accommodated or not.
• Clients’ recommendations for improving preference accommodation in therapy.
Secondary questions include:
1. How can the methodological quality of preferences research be enhanced?
• What is the scope of qualitative studies on client preferences (e.g., qualitative designs and methods, types of therapy, client populations)?
• What are methodological issues in qualitative research on preferences (e.g., client responses before, during or after therapy, influence of data collection mode)?
2. What would a client-generated framework for working with preferences look like?
• How do clients understand and talk about preferences (language, imagery, metaphor)?
• What is the structure of preference domains (e.g., preferences for therapeutic activities, therapist relationship style, flexibility of preferences)?
• What do clients think about how preference conversations impact therapy and the therapeutic relationship?
• What is the meaning for clients when preferences are not accommodated?
As client preference research is still new in psychotherapy, there may be few studies on similar aspects of preferences. Thus, a discovery-oriented approach to data analysis will be employed, sensitive to emergent questions. | This review studies client preference-accommodation before and during counselling and psychotherapy, referring to the process by which therapists consult clients about their preferences—therapeutic approaches, goals, or relational dynamics—and how these are integrated into therapy.
Research shows that accommodated client preferences are associated with improved engagement, better therapeutic outcomes, and lower dropout rates of the patients undergoing treatment (Gibson et al., 2020; Swift et al., 2018). While quantitative studies show benefits of preference-accommodation, qualitative research can offer deeper insights into clients' lived experiences, such as their feelings when their preferences are enquired about, the emotional and relational impact of having preferences accommodated or ignored, and practical implications for improving therapy processes.
Despite growing interest, no comprehensive meta-analytic review of qualitative research on preference-accommodation in psychotherapy has been conducted yet.
The present review will address these gaps by synthesizing qualitative evidence to:
• Examine clients’ experience when consulted about preferences.
• Explore client perceptions of how preference-accommodation affects the therapeutic relationship and outcomes.
• Identify client recommendations for improving therapists’ preference accommodation.
By focusing on this domain, the review aims to provide evidence to inform therapeutic practice that will enhance collaboration between clients and therapists, hence improving therapy outcomes. | null |
CRD42023445068 | What are the results of the measurement of quality of life in older adults with mild cognitive impairment based on the EQ-5D and SF-6D?
What are the health utility values for older adults with mild cognitive impairment base on EQ-5D and SF-6D? | Mild cognitive impairment. Quality of life. Health utility. EQ-5D. SF-6D. | null |
CRD42023425133 | This is a systematic meta-ethnographic study to examine, translate and synthesise insights from published peer-reviewed qualitative literature on –
1. What was the role of community mental health services in influencing mental health outcomes for individuals and systems during COVID-19?
2. What was the relationship between community mental health systems and the wider mental health landscape, particularly institutions (e.g., general hospitals, specialist long-stay facilities), during COVID-19?
3. How did community mental health services shape mental health service delivery and outcomes for individuals and communities during COVID-19? | The domain being examined is community mental health systems and services. This is defined by the American Psychological Association as activities which promote mental health, that are performed in the community instead of institutional settings. | null |
CRD420251003105 | To compare the efficacy and safety of Hypericum perforatum extracts (alone or combined with other herbal components) against placebo or antidepressants (e.g., SSRIs, TCAs) in randomized controlled trials (RCTs). Outcomes include improvements in clinical symptoms, depression scale scores, and adverse event rates, thereby generating evidence-based recommendations for clinical use. | Adolescents or adults (≥10 years) diagnosed with mild, moderate, or severe depressive disorder per DSM or ICD criteria. Comorbid non-psychiatric conditions (e.g., stroke, myocardial infarction) are allowed. Postpartum depression (diagnosed within 4 weeks post-delivery) is included. Hypericum Extract; Hypericum Perforatum Leaf Extract; Hypericum Oil; Monotherapy Hypericum perforatum extracts (monotherapy or combined with other herbs) administered for ≥4 weeks. PICO tags selected: Placebo; Antidepressants; Usual Care | Studies involving bipolar disorder or schizophrenia with comorbid depression (per DSM-V). |
CRD42024614593 | What is the association between experiences of bullying (in childhood, adolescence, and adulthood) and the subsequent development of psychosis in individuals, as measured by psychotic symptoms and diagnosed psychotic disorders? | Bullying, Schizophrenia and psychotic spectrum disorders | null |
CRD420250409989 | What are the psychological outcomes for individuals undergoing cardiac screening following a relative suffering a sudden death or cardiac arrest with no known cause? | Sudden Arrhythmic Death Syndrome (SADS) is an important cause of sudden death in the young, and is defined as a sudden and unexpected death for which no cause can be found, despite thorough post-mortem investigation. Sudden Infant Death Syndrome (SIDS), or 'cot death', applies to infants under one year of age.Unexpected Cardiac Arrest (UCA) is when an individual, who was previously fit and well, suffers a sudden cardiac arrest and is successfully resuscitated. In this case, a proportion of individuals will have no cause found for the arrest despite cardiac investigations, and these can be termed UCA or idiopathic ventricular fibrillation (IVF).A proportion of these events are due to inherited cardiac conditions (ICCs), primarily inherited arrhythmia syndromes, which can predispose individuals to dangerous abnormal heart rhythms in the absence of any structural defects. Therefore, first-degree relatives (parents, children, siblings) are advised to undergo cardiac investigations, ' cardiac screening', to reveal any hitherto undiagnosed ICCs.Due to the unexpected nature of SADS, SIDS and UCA, death of a family member, uncertainty regarding the aetiology and the implied risk, surviving relatives are at high risk of psychological distress. There are limited data on psychological outcomes in this population. 1. Individuals undergoing cardiac screening due to a family history of Sudden Death or Sudden Cardiac Arrest with no known cause (i.e. SADS, SIDS, UCA) Inclusion:1. Clinical cardiac evaluation for inherited cardiac conditions2. Post-mortem genetic testing in a relative following SADS or SIDS | 1. Individuals undergoing cardiac investigations with a known cardiac condition 2. Relatives of individuals who have died suddenly of a known cause, e.g. cardiomyopathy Exclusion: 1. Clinical cardiac evaluation due to a family history of a named inherited cardiac condition, e.g. hypertrophic cardiomyopathy, either due to a pre- or post-mortem diagnosis |
CRD420251016642 | To evaluate and compare the effects of different types of exercise interventions on fatigue, dyspnea, physical function, cognitive function, and quality of life among older adults (aged ≥60 years) with long COVID, through an umbrella review of existing systematic reviews and meta-analyses. | Inclusion: Adults aged 60 years and over who have been diagnosed with long COVID (also referred to as post-COVID syndrome or post-acute sequelae of SARS-CoV-2 infection), as defined by any recognized clinical or research criteria. Participants may be community-dwelling or hospitalized, and studies including mixed-age adult populations will be included if subgroup data for ≥60-year-olds are available or if the average age of participants is ≥60 years. Exclusion: Studies focused exclusively on children or young/middle-aged adults (<60 years), or those that do not specify the age group or long COVID status. Studies focusing only on acute COVID-19 infection (within 4 weeks) will also be excluded. Exercise therapy; Physical Exercises; Aerobic Exercise; Resistance training ; Breathing Exercises; Tai Chi PICO tags selected: Usual Care; Placebo This umbrella review will include systematic reviews and meta-analyses that synthesized randomized controlled trials (RCTs), non-randomized controlled trials, or both. | null |
CRD42024618923 | What would be the emerging new themes from the review qualitative literature about the experiences of suicide survivors? | family, suicide survivors, friends, adolescent, lived experiences, | null |
CRD420250640371 | Primary Review Question:"In patients with idiopathic scoliosis, how do Vertebral Body Tethering (VBT) and Posterior Spinal Fusion (PSF) compare in terms of major and minor Curve correction?"Secondary Review Questions:Radiographic Outcomes:How do VBT and PSF compare in terms of:Coronal balance (C7-CSVL)Spinal height (t1-s1)Shoulder height difference (cm)Thoracic kyphosisLumbar lordosisPatient-Reported Outcomes:How do VBT and PSF affect patient-reported outcomes, including:SRS-22 scores (function, pain, self-image, mental health, satisfaction)Clinical Outcomes:How does postoperative trunk range of motion compare between VBT and PSF in:FlexionExtensionSide bendingAxial rotationSurgical/Perioperative Outcomes:How do VBT and PSF compare in terms of:Length of stay (LOS)Blood lossOperation timeNumber of fused levelsComplication Rates:What are the overall complication rates for VBT vs. PSF?How do VBT and PSF compare in terms of revision surgery rates? | Adolescent Idiopathic Scoliosis; Scoliosis Deformity Of Spine Idiopathic scoliosis is a structural lateral curvature of the spine with a rotational component, occurring in otherwise healthy individuals without a known cause. It is the most common type of scoliosis and is classified based on the age of onset: infantile idiopathic scoliosis (IIS) (0–3 years), juvenile idiopathic scoliosis (JIS) (4–9 years), adolescent idiopathic scoliosis (AIS) (10–18 years), and early-onset scoliosis (EOS) (0–10 years). AIS is the most prevalent form, often progressing during periods of rapid growth, such as adolescence. The condition can lead to cosmetic deformities, pain, and, in severe cases, cardiopulmonary compromise due to thoracic deformity.The primary goal of treatment is to prevent curve progression and correct deformity while preserving spinal mobility and function. Surgical intervention is considered when the curvature exceeds a certain threshold (typically >45–50 degrees) or shows significant progression. This systematic review focuses on comparing two surgical approaches: Vertebral Body Tethering (VBT), a newer, motion-preserving technique, and Posterior Spinal Fusion (PSF), the traditional gold standard. The review evaluates radiographic outcomes, perioperative parameters, patient-reported outcomes, and complication rates to provide evidence-based insights into the comparative effectiveness and safety of these two surgical Inclusion criteriaPatients diagnosed with early-onset scoliosis (EOS) or adolescent idiopathic scoliosis (AIS).Studies reporting on patients who treated with either Vertebral Body Tethering (VBT) or Posterior Spinal Fusion (PSF).Studies reporting radiographic, patient reported outcomes and complications with a minimum follow-up period of 2 years.Studies reporting clinical outcomes on range of motion and perioperative outcomesProspective or retrospective studies and randomised control trialsExclusion criteriaStudies involving other surgical techniques or hybrid constructsPatients with a history of prior spine surgery.Studies reporting radiographic, patient reported outcomes and complications with less than 2 years of follow-up.Patients with scoliosis of non-idiopathic origin, including congenital, syndromic, or neuromuscular scoliosis.Patients with a history of spinal infection, tumor, or trauma.Review and meta-analysis type articles Intervention group: Patients with idiopathic scoliosis treated with Vertebral body tethering Control group: Patients with idiopathic scoliosis treated with Posterior spinal fusion | null |
CRD42022354851 | The main objective of this systematic review is evaluate the psychometric properties of the "Illness Management and Recovery Scale" from its creation to the present date, using the Consensus based Standards for the selection of health Measurement Instruments (COSMIN) method. | The construct “recovery” is a new paradigm used in mental health defined as a deeply personal, unique process of changing one's attitudes, values, feelings, goals, skills and/or roles. It is a way of living a satisfying, hopeful, and contributing life even with limitations caused by the illness. The Illness Management and Recovery Scale (Mueser et al., 2005) aims to quantify the perceptions that each individual has of their recovery odds, their personal goals and difficulties in coping with the mental health problem. | null |
CRD42021235312 | What is the effectiveness of virtual reality treatment when compared to other conservative and non-conservative therapies to reduce pain, improve range of motion and quality of life in patients with musculoskeletal disorders? | Musculoskeletal disorders (MSKD) are injuries and dysfunctions that have a negative impact on the human musculoskeletal system. They include all diseases of the musculoskeletal system, from temporary inflammatory injuries to degenerative, disabling disorders. These include health problems of muscles, tendons, ligaments, cartilage, nerves, and blood vessels, among others. They are the most common cause of chronic pain, physical functional impairment, and loss of quality of life.[23],[24]
The most common musculoskeletal disorders are low back pain, osteoarthritis, shoulder pain, among others. This systematic review will focus on the effect of virtual reality treatments on patients with musculoskeletal disorders except for those MSK disorders of the orofacial, cranial, and cervical regions. | null |
CRD420251001878 | To evaluate the efficacy and safety of Intraneural facilitation in patients with diabetic neuropathy, compared with placebo or standard care, on neuropathic pain and nerve function. | a Randomized Controlled Trials or quasi-RCT research involves adult patients, aged 18 years and above, who have been clinically diagnosed with either type 1 or type 2 diabetes. These patients undergo clinical assessment, nerve conduction studies, and validated neuropathy scales to provide evidence or diagnosis of peripheral diabetic neuropathy. and they treat with intraneural facilitation to treat diabetic neuropathy. This includes only articles published in the English language. Intraneural facilitation therapy placebo or standard of care. | Studies in pediatric populations (<18 years), Studies that do not diagnose or report on diabetic peripheral neuropathy study design other than RCT as case reports, case series with petite sample sizes, conference abstracts that lack sufficient outcome data, narrative reviews, systematic reviews, meta-analyses, editorials, or letters. Animal or in vitro studies are not included in this category. the poor-quality study, not an available long article |
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